Serological evidence of infection by Pichinde virus among laboratory workers. A total of 44 laboratory workers were examined for serological evidence of infection by Pichinde virus. Complement-fixing antibodies were detected in the sera of 6 of 13 (46%) persons working with the virus but not among 31 persons not working with the virus. Serological evidence of infection was greatest among those workers exposed to concentrated virus. No distinct illness could be associated with the infection.


Diagnosis and treatment of diseased horseshoe kidney.


Appendix duplex.

Appendix duplex.


Pregnancy complicated by acute idiopathic thrombocytopenic purpura. A report of two patients treated by simultaneous caesarean section and splenectomy.


Gonadotropin release in relation to electrical activity in hypothalamic neurons.


Antifertility effect of CS-1 in the rat.


Progestin-induced pseudohermaphroditism in the female hamster.


Influence of cyproterone acetate during pregnancy on the sexual behaviour of male guinea-pigs.


An autoradiographic study of the post-natal changes in (3H)leucine incorporation by Sertoli cell nuclei in rat testes.


Cell proliferation in the uterus of the guinea-pig.


Effect of dietary restriction on ovarian compensatory hypertrophy in the rat.


A microtube culture method for mouse oocytes.


Mammalian fertilization in vitro: sperm-induced preparation of the zona pellucida of golden hamster ova for final binding.


Permanent sterility in the male rat after a single oral dose of pipecolinomethyl-hydroxyindane. A single oral dose (150 mg/kg) of DL-6-(N-alpha-pipecolinomethyl)-5-hydroxy-indane maleate dissoved in distilled water was administered to Sprague-Dawley male rats living under controlled conditions. After dosage the male rats cohabited with female rats which were replaced weekly.  The incidence of pregnancy was determined for 20 weeks.  The male rats were then killed and the testes examined histologically.  Results showed subnormal fertility at the 3rd and 4th week, sterility at the 5th week.  Sterility persisted until Week 20.  Histological evidence showed absence of spermatogenic cells in treated rats with no signs of regeneration.


DNA configuration in the core of Marek's disease virus. Marek's disease virus DNA appears to be wound around a central structure connecting the two inner poles of the capsid. Based on electron micrographs of Marek's disease virions, a diagram of spatial configuration of virus DNA is presented. This diagram may explain the pleomorphic character of the herpesvirus core observed with the electron microscope.


Platelet disorders. Advances in understanding and management.


Environmental levels of radioactivity at Atomic Energy Commission installations. 1. Hanford Atomic Products Operation, January-December 1970.


Observations on African and European strains of Arthroderma benhamiae.


Canine hyperkinesis.

Canine hyperkinesis.


Ribonucleoprotein particles of the cytoplasm of the mouse plasmocytoma.


Molecular mechanism of the protection of DNA during ultraviolet irradiation of deoxyribonucleoproteins.


Physicochemical and catalytic properties of aspartate aminotransferase selectively modified at the tyrosine and cysteine residues.


Considerations of the pathogenesis of neonatal hepatitis, biliary atresia and choledochal cyst--the concept of infantile obstructive cholangiopathy.


Inhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient rats.


Effects of prostaglandin F-2 alpha (PGF-2 alpha) on the length of pseudopregnancy in normal and iud bearing hamsters.


Independence of spinal cord and medulla oblongata on thermal activity.


Antibody response to a human diploid cell rabies vaccine. An experimentally killed rabies virus vaccine prepared in a human diploid cell strain (WI-38)-Wyeth rabies vaccine (WRV)-was used by various injection schedules in two separate studies to define more closely in human volunteer subjects an effective vaccination schedule for pre- or postexposure immunization, particularly for donors of rabies-hyperimmune plasma. To permit valid comparisons between our results and those of other workers, antibody levels achieved were expressed in terms of international units (IU) per milliliter of serum. Antibody response of previously nonvaccinated persons were only modest after a single dose of WRV, never reaching a level higher than 0.80 IU/ml over a 56-day testing period. Moreover, antibody was not detected at 0.16 IU/ml before the 14th day, either after a single dose or after two doses given 3 days apart. The best response followed four doses of WRV given within 4 weeks. This schedule resulted in the highest rate of seroconversion to the >/=6 IU/ml antibody level required of potential rabies-immune plasma donors. Giving the first vaccine dose in aluminum hydroxide diluent did not enhance the antibody response. There was a definite suggestion in the various injection schedules that higher and more sustained antibody levels were reached when the interval between the first and second vaccine doses was longest. The greater immunogenicity of WRV as compared with duck embryo vaccine was best demonstrated by the fact that a single booster dose of duck embryo vaccine to previously vaccinated individuals resulted in only a sevenfold antibody rise during the following 56 days, whereas a booster dose of WRV elicited a 69-fold rise. Al(OH)(3) in the first dose of WRV had no effect, but the enhancing effect of a longer interval between vaccine doses was noted once again; 20 of 20 subjects who received three doses of WRV with 4 weeks between doses developed good levels of rabies antibody, and 19 exceeded 6 IU/ml.


Sodium, an obligate growth requirement for predominant rumen bacteria. Sodium is an obligate growth requirement for most currently recognized predominant species of rumen bacteria. The isoosmotic deletion of Na(+) from a nutritionally adequate defined medium completely eliminated growth of most species. Growth yields and rates were both a function of Na(+) concentration for Na(+)-requiring species, and Na(+) could not be replaced by Rb(+), Li(+), or Cs(+) when these ions were substituted for Na(+) at a concentration equivalent to an Na(+) concentration that supported abundant growth. Li(+), Cs(+), or Rb(+) was toxic at an Na(+)-replacing concentration (15 mM) but not at a K(+)-replacing concentration (0.65 mM). K(+) was also an obligate growth requirement for rumen bacteria in media containing Na(+) and K(+) as major monovalent cations, but K(+) could be replaced, for most species, by Rb(+). The quantities of Na(+) that support rapid and abundant growth of Na(+)-requiring rumen bacteria show that these organisms are slight halophiles. A growth requirement for Na(+) appears more frequent among nonmarine bacteria than has been previously believed.


Effects of guancydine on catecholamine synthesis storage and catabolism.


Fluorescent whitening agents. II. Covalent binding to proteins during irradiation by sunlight.


Effects of genotype and nutrition before mating on the reproductive performance of mice.


A comparative study of the interaction of ochratoxins with bovine serum albumin.


Cobalt-induced alterations in plasma proteins, proteases and kinin system of the rat.


A theoretical consideration of the abnormal behavior of histones on sodium dodecylsulfate gel electrophoresis.


Separation of proteins with polyacrylic acids.


Characteristic behaviors of 2-(4'-hydroxyphenylazo)-benzoic acid to native and heat-denatured serum albumins.


Structure-volume relationships for proteins. Dilatometric study of the reaction of bovine hemoglobin with sodium dodecylsulfate, hydrogen and hydroxylions.


Binding of indole compounds with modified albumins: characterization of the indole binding site.


Crossed immunoelectrophoresis of human erythrocyte membrane proteins. Immunoprecipitation patterns for fresh and stored samples of membranes extensively solubilized with non-ionic detergents.


Letter: Doctors, drivers, and confidentiality.


Prepyriform seizure thresholds during the estrous cycle in female rats.


Effect of phytohaemagglutinin in the leucocyte migration inhibition test as a measure of cell-mediated immunity. Evaluation of responsiveness to phytohaemagglutinin (PHA) in the leucocyte-migration inhibition test has been extended to a greater number of patients and control subjects to explore the range of the test. The patients, mainly with sarcoidosis, were found to be less responsive than controls. The conditions of the test in terms of concentration of PHA, duration of culture, and serum concentration used were investigated and standards suggested. Intraperson variation and the influence of age were also evaluated.


Proceedings: Urological investigation in women with recurrent incontinence following gynecological surgery.


Proceedings: Clinical and hydrodynamic evaluation of urinary incontinence in women: clinical aspects and analysis of results.


Proceedings: Studies of intra-urethral pressures in normal and incontinent women.


Proceedings: Experience with vaginal and anal pacemakers.


Proceedings: Intra-urethral pressure profile and stimulation results in urinary incontinence.


Editorial: Alcoholism and its identification.


Complications of argon laser photocoagulation.


Argon laser trabeculotomy.

Argon laser trabeculotomy.


"Experimental neurosis" in cats: fact or artifact?


Invasive illness with Salmonella virchow infection. Salmonella virchow infection in man is usually sporadic and is little known in Britain. We report an outbreak of 21 cases in the Manchester area. The source of infection was believed to be chickens bought at different shops. Symptoms were typhoidal or septicaemic.


Fibrinogen Cleveland II. An abnormal fibrinogen with defective release of fibrinopeptide A. An abnormal fibrinogen (fibrinogen Cleveland II) was detected in the plasma of a 23-yr-old white man with a mild bleeding diathesis. The one-stage prothrombin time, thrombin time, and Reptilase time were all prolonged. 16 of 24 tested relatives had the defect, which appeared to be transmitted as an autosomal dominant characteristic. The thrombin time of normal plasma was slightly inhibited by the proband's plasma. The abnormally long thrombin time of fibrinogen Cleveland II was partially corrected by addition of calcium ions. Fibrinogen Cleveland II was indistinguishable from normal fibrinogen by immunoelectrophoresis, DEAE-cellulose column chromatography, or polyacrylamide gel electrophoresis of reduced fibrinogen in sodium dodecyl sulfate. The major defect detected appeared to be impaired release of fibrinopeptide A when fibrinogen Cleveland II was incubated with thrombin. This defect was localized to the NH(2)-terminal disulfide knot portion of the molecule. An abnormality of polymerization of fibrin monomers was also present, but the abnormal fibrin demonstrated relatively normal crosslinking. Despite these defects, fibrinogen Cleveland II achieved a degree of coagulability similar to normal fibrinogen and appeared to incorporate some molecules of fibrin with intact fibrinopeptide A into the clot. The fibrin clot that was formed appeared to be abnormal by electron microscopy. These functional defects and other descriptive characteristics appear to distinguish fibrinogen Cleveland II from other inherited abnormal fibrinogens.


Ruby laser photocoagulation therapy of central serous retinopathy. I. A controlled clinical study. II. Factors affecting prognosis.


Antibody and resistance to infection with Yersinia pestis in the progeny of immunized rats.


A model of the kinetics of insulin in man. The design of the present study of the kinetics of insulin in man combines experimental features which obviate two of the major problems in previous insulin studies. (a) The use of radioiodinated insulin as a tracer has been shown to be inappropriate since its metabolism differs markedly from that of the native hormone. Therefore porcine insulin was administered by procedures which raised insulin levels in arterial plasma into the upper physiologic range. Hypoglycemia was prevented by adjusting the rate of an intravenous infusion of glucose in order to control the blood glucose concentration (the glucose-clamp technique). (b) Estimation of a single biological half-time of insulin after pulse injection of the hormone has been shown to be inappropriate since plasma insulin disappearance curves are multiexponential. Therefore the SAAM 25 computer program was used in order to define the parameters of a three compartment insulin model. The combined insulin mass of the three compartments (expressed as plasma equivalent volume) is equal to inulin space (15.7% body wt). Compartment 1 is apparently the plasma space (4.5%). The other two compartments are extra-vascular; compartment 2 is small (1.7%) and equilibrates rapidly with plasma, and compartment 3 is large (9.5%) and equilibrates slowly with plasma. The SAAM 25 program can simulate the buildup and decay of insulin in compartments 2 and 3 which cannot be assayed directly. Insulin in compartment 3 was found to correlate remarkably with the time-course of the servo-controlled glucose infusion. Under conditions of a steady-state arterial glucose level, glucose infusion is a measure of glucose utilization. We conclude that compartment 3 insulin (rather than plasma insulin) is a more direct determinant of glucose utilization. We suggest that the combined use of glucose-clamp and kinetic-modeling techniques should aid in the delineation of pathophysiologic states affecting glucose and insulin metabolism.


A simple method for large-scale preparation of chick embryo tRNA.


Ultraviolet hypochromism in the interaction systems of DNA and carcinogenic 2-anthramine and its related compounds.


Demonstration of beta-glucuronidase in disk electrophoresis by means of 5-bromoindol-3-yl-beta-D-glucuronide.


Capacitation of boar spermatozoa: synergism between uterine and tubal environments.


Delayed maturation of the renal cortex in the vitamin B6-deficient newborn rat.


The expected changes in the frequency of alleles affecting the sex ratio.


Density dependent selection in parthenogenetic and self-mating populations.


Powassan virus infection. A report of three human cases of encephalitis.


The post-graduate education and training of consultant psychiatrists.


Proceedings: Atypical phenylketonuria accompanied by a severe progressive neurological illness unresponsive to dietary treatment.


Lead-induced behavioral dysfunction: an animal model of hyperactivity.


Localization of cations in the peripheral nerve fiber by the K-pyroantimonate method.


Urinary incontinence due to multiple urogenital anomalies in a mature dog.


Chemical composition and structure of fluorotic bone.


Cytotoxic immune cells with specificity for defined soluble antigens. V. Interaction of antibody with the cytotoxic effector cells in immune or non-immune mouse spleen cells.


Cellular bases for relative radioresistance of the antibody-forming system at advanced stages of the secondary response to tetanus toxoid in mice.


Letter: A reexamination of terms.

Letter: A reexamination of terms.


Diffuse scattering of x-rays by solutions of synthetic polypeptides and globular proteins.


Of hooch and hazards--alcoholism and accidents in industry.


Use of plastics for suspension culture vessels.


Cooperative training for student nurses.


Illusory correlation of brightness enhancement and transients in the nervous system. Short light flashes can appear brighter than longer flashes. This brightness enhancement has often been attributed to neural transients occurring shortly after stimulus onset. This attribution assumes an equivalence between the totality of the response to a stimulus of a given duration and the instantaneous response at a given time after stimulus onset. Recordings from Limulus photoreceptors indicate that this attribution is an example of illusory correlation.


Twixt the cup and the plate--alcohol and nutrition--in the health care of patients.


The problem drinker on your payroll.

The problem drinker on your payroll.


Effect of transformation by hamster sarcoma virus on the glycolipid composition of secondary hamster embryo cells and the Nil cell line.


Serum inorganic fluoride levels in patients receiving enflurane anesthesia.


Nitrous oxide content in the operating suite.


Ketamine-gallamine anesthesia for great-vessel operations in infants.


The prophylactic antiemetic effect of droperidol.


Clinical experience with subanesthetic ketamine.


Ketamine hydrochloride for pediatric premedication. I. Comparison with pentazocine.