Animal models of human disease: severe and mild lead encephalopathy in the neonatal rat. Inorganic lead produces cerebral dysfunction and clinically definable encephalopathies in man. To date there have been few studies on the biochemical changes in brain following exposure to inorganic lead. Studies correlating toxicity with behavioral and brain neurochemical changes following lead exposure have been hindered because adult laboratory animals are resistant to the central nervous system effects of lead poisoning. Such studies have been impeded by lack of suitable experimental models until Pentschew and Garro showed that brain lesions develop in neonatal rats when a pregnant rat newly delivered of her litter is placed on a 4% lead carbonate containing diet. Lead passes into the developing sucklings via maternal milk. Lead-poisoned new-borns have pronounced retardation of growth and during the fourth week of ilfe develop the severe signs of lead encephalopathy, namely, extensive histological lesions of the cerebellum, brain edema, and paraplegia. There is an approximate 85-fold increase in the lead concentration of both the cerebellum and cerebral cortex relative to controls, but edema and gross vascular changes are confined to the cerebellum. Ingested lead had little effect on RNA, DNA, and protein concentrations of developing rat cerebellum and cerebral cortex. However, there was a reduction of between 10 and 20% in the DNA content of the cerebellum around 3 weeks of age in the lead-exposed sucklings. This suggests a failure of cell multiplication in this part of the brain.A critical evaluation of this experimental approach indicated that under similar dietary conditions experimental lactating rats eat 30% less food than controls resulting in: (a) sustained loss in body weight of nursing mothers and that (b) offsprings who develop paraplegia and cerebellar damage do so after gaining access to lead containing diet. We have studied mothers' food consumption and body weight changes and blood, milk, and brain lead content; and newborns' body and brain weight changes, blood and brain lead content, and brain serotonin (5HT), norepinephrine (NE), dopamine (DA), and gamma-aminobutyric acid (GABA). We have found that a lactating mother rat eating 5% lead acetate (2.73% Pb) produced milk containing 25 ppm lead. When the mothers' diet is changed at day 16 from 5% PbAc to one containing 25 ppm Pb, and neonates allowed free access to the solid diet, the sucklings still have retarded body growth but do not develop paraplegia or grossly apparent vascular damage of the cerebellum. However, during the fourth week these animals exhibit a less severe form of "encephalopathy" consisting of hyperactivity, tremors, and stereotype behavior. Pair-fed controls coetaneous to experimental groups do not display such activities. There was no change in brain 5HT, GABA, or NE, but a 15-20% decrease in brain DA. Change in DA relative to other monoamines suggests a relationship between CNS dysfunction due to lead and DA metabolism in the brain.The experimental design as discribed provides a model of CNS dysfunction due to lead exposure without debilitating histopathologies. It is possible that our findings on increased motor activity and changes in brain dopamine may correspond to early responses to lead exposure before recognized overt signs of toxicity.


In situ hybridization of iodinated ribosomal RNA to human chromosomes.


Variations in hematologic responses to increased lead absorption in young children. In the study of human populations, much emphasis is placed on the concentration of lead in whole peripheral blood. There is a considerable body of evidence which indicates that this measurement reflects recent and current assimilation of lead. While broad ranges in blood lead concentration have been associated with differing risks of toxicity for groups, it is not a precise index of adverse effect per se, even at elevated levels. Within the red blood cell itself there is not a close association between the concentration of lead and such adverse metabolic effects as the increased loss of potassium caused by lead. Above the apparent "threshold zone" of approximately 30-50 mug Pb/100 ml whole blood, equivalent metabolic effects on heme synthesis may be seen over an interval of at least 20 mug Pb/100 ml whole blood. This variation will be examined with particular reference to the interrelationship between the concentrations of lead and protoporphyrin in peripheral blood. The data indicate that limitations in both precision and accuracy of measurement account for a relatively small fraction of the observed variations. Together with other experimental and clinical information, they suggest that concurrent dietary deficiency of iron may be one of the important modifying factors in the responses of subjects with increased lead absorption. It is suggested that suspected adverse effects upon the various organ systems associated with increased lead absorption be measured directly and that the CaEDTA mobilization test for lead should be more fully explored as a measure of the "metabolically active" fraction of the total body lead burden.


Polysomes of the sea urchin embryo. Identification of tubulin-synthesizing polysomes.


New information on lead in dirt and dust as related to the childhood lead problem. It has been known for many years that the eating of leaded paint is the prime cause of lead poisoning and elevated blood leads of children living in deteriorated housing. Recently, there has been speculation that children may eat dirt and dust contaminated with lead exhausted from cars and that this amount of ingested lead is sufficient to contribute significantly to the childhood lead problem. This paper reports on a twopart study conducted to evaluate the validity of the dirt-and-dust hypotheses. The first part of the study was made to determine the source of lead in dirt to which children are normally exposed. Dirt samples were taken in old urban areas around 18 painted frame houses and 18 houses of brick construction. Samples also were taken around seven old frame farmhouses remote from traffic. Based on the fact that lead concentrations in the dirt were similar in city and rural yards at corresponding distances from the houses, it is clear that nearly all of the lead in dirt around these houses is due to paint from the houses. Lead antiknock additives are therefore not a significant contributor to the lead content of dirt around houses where children usually play. The second part of the study used a naturally occurring radioactive tracer (210)Pb to determine the relative amounts of dust and other lead-containing materials (e.g., paint) eaten by young children. This tracer is present in very low concentrations in paint and in significantly higher concentrations in fallout dust. Stable lead and (210)Pb were analyzed in fecal material from eight children suspected of having elevated body burdens of lead and ten children living in good housing where lead poisoning is not a problem. The normal children averaged 4 mug Pb/g dry feces, with a range of 2 to 7. Of the eight children suspected of having elevated lead body burdens, two had fecal lead values within the normal range. However, the remaining six were 4 to 400 times as high. Despite these differences in fecal lead between the two groups, the groups were essentially identified in the (210)Pb content of their feces. The "elevated" children averaged 0.040 pCi of (210)Pb dry feces, while the normal group averaged 0.044 pCi/g. The results provide sound evidence that these children suspected of elevated lead body burden were not ingesting dust or air-suspended particulate.


Lead analysis of house dust: a method for the detection of another source of lead exposure in inner city children. A method has been developed to test the hypothesis that lead-containing house dust is responsible for the elevated levels of lead in blood of inner city children. Dust analyses of smears from the floors, walls, and windowsills in low-income inner city dwellings have shown a median concentration of lead five times as high in suburban homes. It is suggested that lead-containing dust may be one of the most important environmental sources of increased lead exposure in this specific population group.


Nucleolar activity of rat primary spermatocytes.


Rectangular arrays of particles on freeze-cleaved plasma membranes are not gap junctions.


The effect of exogenous DNA upon cleaving mouse embryos.


The stability of messenger RNA containing polyadenylic acid sequences in rabbit blastocysts.


Frequency and sites of sister chromatid exchanges in rat kangaroo chromosomes.


Changes in the content of ATP and GTP during the development of X.


Endoreduplication induced by hydroxylamine sulfate in Zea mays root tip nuclei.


Changes in cellular ATP, ADP and AMP levels following treatments affecting cellular respiration and the activity of certain nuclear genes in Drosophila salivary glands.


Autoradiographic analysis of macromolecular synthesis in prospectively necrotic cells of the chick limb bud. I. Protein synthesis.


American Pharmaceutical Association: reinbursement policy for prescription drugs.


The quality and cost of prescription drugs.


Contraceptives available by prescription. The article presents a comprehensive review of the common contraceptive methods.  Contraceptive preferences are ranked in tables by physicians and patients with unanimity on oral contraceptives as first preference.  Tables also show combination oral contraceptives, sequential oral, and pregestin only contraceptives by trade name, manufacturer, number of tablets per dispensing unit, and progestogen and/or estrogen content.  Women using sequential pills are seen to run a greater risk of thromboembolism.  Discussion on contraceptive pills includes the effectiveness of various types of pills, the infertility mechanism, physicians' attitudes towards prescribing, risks, side effects and other reasons for nonuse, contraindications, and  prescriptive precautions.  IUDs are described and discussed regarding comparative effects and action of various types IUD, detractive aspects, precautions, and evaluation of the IUD as a contraceptive.  Other contraceptives discussed are the diaphragm, cervical cap, sterilization, and abortion.


A potential role for the pharmacist. Medicine problems confronted by the schizophrenic outpatient.


Sugar transport in chick embryo fibroblasts. I. A functional change in the plasma membrane associated with the rate of cell growth.


Lipophosphonoglycan of the plasma membrane of Acanthamoeba castellanii. Fatty acid composition.


Lipophosphonoglycan of the plasma membrance of Acanthamoeba castellanii. Isolation from whole amoebae and identification of the water-soluble products of acid hydrolysis.


Sugar transport in chick embryo fibroblasts. 3. Evidence for post-transcriptional and post-translational regulation of transport following serum addition.


The reacylation of deacylated derivatives of diphosphatidylglycerol by microsomes and mitochondria from rat liver.


Photosynthetic path of carbon dioxide in spinach and corn leaves.


Transport of L-isoleucine by cultured human fibroblasts. Uptake by normal cell lines and isolation of a cell line lacking sodium-dependent uptake.


An N-acetylgalactosaminyltransferase from human blood group A plasma. II. Kinetic and physicochemical properties.


Purification and properties of glycohydrolase from calf thymus splitting ribose-ribose linkages of poly(adenosine diphosphate ribose).


The developmental regulation of amylolytic and proteolytic enzymes in the embryonic rat pancreas.


Structural aspects of manganese-pyruvate kinase substrate and inhibitor complexes deduced from proton magnetic relaxation rates of pyruvate and a phosphoenolpyruvate analog.


Isolation and characterization of subunits from equine pituitary follicle-stimulating hormone.


Inactivation of glucose carriers in human erythrocyte membranes by 1-fluoro-2,4-dinitrobenzene.


Human erythrocyte sugar transport. Kinetic evidence for an asymmetric carrier.


Equine hepatic and renal metallothioneins. Purification, molecular weight, amino acid composition, and metal content.


4,4'-Bis-dimethylaminodiphenylcarbinol modification of active center sulfhydryl residues in malate dehydrogenase.


An N-acetylgalactosaminyltransferase from human blood group A plasma. I. Purification and agarose binding properties.


Studies on the function of glucocorticoid in mouse mammary epithelial cell differentiation in vitro. Stimulation of glucose 6-phosphate dehydrogenase.


A survey of respiratory care resources in Florida.


Avoiding referral mistakes--a function of good manners.


Adult respiratory distress syndrome. Report of 18 cases.


A report on physician distribution in Florida.


Senior medical consultants.

Senior medical consultants.


Editorial: FDA--approved?

Editorial: FDA--approved?


Amoxicillin.

Amoxicillin.


Gels and other topical corticosteroids.

Gels and other topical corticosteroids.


Effect of prostaglandin precursors, dihomo-gamma-linolenic acid and arachidonic acid on the vasoconstrictor response to norepinephrine in the dog paw.


PGF2alpha 15-methyl ether methyl ester.

PGF2alpha 15-methyl ether methyl ester.


The distribution of prostaglandins A, E, and F in the human kidney.


The termination of first trimester pregnancy by extraovular "prostaglandin-impact".


The International Reference Center for Information on Psychotropic Drugs: activities, plans and news briefs.


Haematological evaluation of the Björk-Shiley tilting disc valve prosthesis in isolated aortic valvular disease.


Aortic valve replacement in patients over the age of sixty.


Parietal fibroplastic endocarditis (Loeffler's disease). Radiological and surgical aspects in connection with a case report.


Cardiac and aortic injuries.

Cardiac and aortic injuries.


Anastomotic false aneurysms following femoropopliteal vein bypass. A case report.


Semi-closed thrombendarterectomy in the treatment of lower limb arteriosclerosis.


Pulmonary sequestration. A case of an intermediate link between extra- and intralobar sequestration and its haemodynamics.


Massive unilateral pulmonary oedema as a rapid re-expansion sequel (the post-expansion syndrome). Report of a case and review of the literature.


Congenital hypoplasia of the lower limb arteries. A report of two cases.


The incidence of deep venous thrombosis in patients with leg oedema after arterial reconstruction.


Regional cerebral blood flow in organic dementia and in chronic schizophrenia.


Quantification of myocardial damage.

Quantification of myocardial damage.


Dying--from the patient's point of view.


Democracy in the hearing impaired classroom.


The surdo-cardiac syndrome with prolonged Q-T interval.


Tri-sensory language stimulation with the TAVF unit.


The role and value of an eurhythmics program in a curriculum for deaf children.


Family therapy of deaf parents and hearing children: a new dimension in psychotherapeutic intervention.


A survey of theatre activities in American and Canadian schools for the deaf 1965-70.


Observing the communication behavior of deaf-blind children.


Clinical correlation with quantitative gastric acid measurements.


Intestinal metaplasia of the gastric mucosa. Endoscopic recognition and review of the literature.


Enterogenous cyst of the duodenum.

Enterogenous cyst of the duodenum.


Transfiberscopic removal of esophageal polyps.


The amylase-creatinine clearance ratio. Diagnostic parameter or physiologic phenomenon?


Removal of a safety pin from the duodenum with the fiberoptic endoscope.


The radiology corner. Eosinophilic enteritis.


Herniation of cecum and terminal ileum through the foramen of Winslow.


Third F. Raymond Keating, JR., Memorial Symposium--parathyroid hormone, calcitonin and vitamin D: clinical considerations. I. Introduction.


Spectrum of hyperparathyroidism.

Spectrum of hyperparathyroidism.


Selective arteriography, venography and venous hormone assay in diagnosis and localization of parathyroid lesions.


Treatment of primary hyperparathyroidism.


Radioimmunoassay of parathyroid hormone in hypercalcemic patients with malignant disease.


Prevention and reversal of progressive secondary hyperparathyroidism in patients maintained by hemodialysis.


Parathyroid function in human vitamin D deficiency and vitamin D deficiency in primary hyperparathyroidism.


Effectiveness of parathyroid hormone, calcitonin and phosphate on bone cells in Paget's disease.


Treatment of Paget's disease of bone with synthetic human calcitonin: biochemical and roentgenologic changes.


Clinicopathologic conference: Marantic endocarditis.


Extensive leukemic infiltration of the gastrointestinal tract in chronic lymphosarcoma cell leukemia.


Acquired "storage pool disease" of platelets associated with circulating antiplatelet antibodies.


The isolation, purification, and characterization of cis-zeta-carotene and the demonstration of its conversion to acyclic, monocyclic and dicyclic carotenes by a soluble enzyme system obtained from the plastids of tangerine tomato fruits.


Biosynthesis of the 27 S thyroid iodoprotein.


Conformational changes in liver alcohol dehydrogenase upon nucleotide binding: detection by circular dichroism of dye complexes.


Identification of a carbon-oxygen lyase activity cleaving the ether linkage in carboxymethyloxysuccinic acid.


Fat metabolism in higher plants. Properties of a soluble stearyl-acyl carrier protein desaturase from maturing Carthamus tinctorius.


Ion-electrode study of magnesium(II)-ATP and manganese(II)-ATP association.


Nomenclature for vitamins B-6 and related compounds: recommendations (1973). IUPAC-IUB Commission on Biochemical Nomenclature (CBN).


Changes in reactivity of mitochondria with 1-dimethylaminonaphthalene-5-sulfonyl chloride (dansyl chloride) transforming from deenergized to energized state.


Determination of oxidation-reduction potentials by spectropolarimetric titration: application to several iron-sulfur proteins.


Studies on glutathione-S-arene oxidase transferase. A sensitive assay and partial purification of the enzyme from sheep liver.


The purification of Aeromonas aminopeptidase by affinity chromatography.


Chemical modification of mitochondria. Uncoupler binding by mitochondria in different metabolic states.


Interactions between mammalian cell DNA and inorganic platinum compounds. II. Interstrand cross-linking of isolated and cellular DNA by platinum(IV) compounds.


Interactions between mammalian cell DNA and inorganic platinum compounds. I. DNA interstrand cross-linking and cytotoxic properties of platinum(II) compounds.


Effects of chronic methadone treatment on bile flow and on metabolism and excretion of 3H-methadone. Experiments with isolated perfused rat livers.


Occurrence of N-urocanylhistamine in the soft tissues of the gastropod molluse Drupa concatenata Lam.


Fluorescent probe analysis of the lipid architecture of natural and experimental cholesterol-rich membranes.


Antibody formation in response to liposomal model membranes sensitized with N-substituted phosphatidylethanolamine derivatives.


Interaction of Miracil D with double-stranded poly(adenylic acid)-poly(uridylic acid).


Comparative studies on homopolymers of adenylic acid possessing different C-2' substituents of the furanose. Poly(deoxyriboadenylic acid), poly(riboadenylic acid),poly(2'-O-methyladenylic acid), and poly(2'-O-ethyladenylic acid).


Hydroxylapatite-catalyzed degradation of ribonucleic acid.


Oxygen binding by callianassa californiensis hemocyanin.


Subunits and association equilibria of Callianassa californiensis hemocyanin.


Isothermal denaturation of aqueous staphylococcal enterotoxin B by guanidine hydrochloride, urea, and acid pH.


On the tetramer-dimer equilibrium of carbon monoxyhemoglobin in 2M sodium chloride.


Chemical composition, affinity for calcium, and some related properties of the vitamin D dependent calcium-binding protein.


Practical aspects of calculating protein secondary structure from circular dichroism spectra.


Binding of lanthanide ions to thermolysin.


Pyruvate kinase isozymes from rat intestinal mucosa. Characterization and the effect of fasting and refeeding.


Physicochemical characterization of renal dipeptidase.


The protoporphyrin-apoperoxidase complex. Photooxidation studies.


New oxygenases in the degradation of flavones and flavanones by Pseudomonas putida.


Mammary tumors in dogs: survey of clinical and pathological characteristics.


Incidence of mycotic gastritis in calves up to 30 days of age.


An outbreak of abortion in a dairy herd following inoculation with an intramuscular infectious bovine rhinotracheitis virus vaccine.


Fractures of the scapular tuberosity.

Fractures of the scapular tuberosity.


Cholangiohepatitis in a cat associated with a coccidia-like organism.


The clinical significance of 2,3 diphosphoglycerate.


The diagnosis and medical management of pulmonary embolic disease.


Surgical treatment of pulmonary embolism and the complication of deep vein thrombus.


An extralobar bronchopulmonary sequestration associated with double ureter and cervical vertebral malformation.


Cardiovascular effects of narcotics.

Cardiovascular effects of narcotics.


Control of intracranial pressure during anesthesia.


Environmental hazards in the operating room.


"Halothane hepatitis".

"Halothane hepatitis".


Reflections from the Dean's Office.

Reflections from the Dean's Office.


The Long-Ribicoff bill.

The Long-Ribicoff bill.


A comprehensive plan for Psychiatric Services for the Capital Region.


Professional negligence in hospital emergency rooms.


Normal pressure hydrocephalus: a controversial entity.


Psychogeriatrics: a design for care of mentally ill older patients.


Proposals would correct inequities, protect civil and exonomic rights of aged.


Recognizing and avoiding adverse gastrointestinal effects of drugs.


The family interview: helping patient and family cope with metastatic disease.


Special problems in respiratory diseases.


Open house--a meaningful, inside look.

Open house--a meaningful, inside look.


Implications of new minimum wage law.

Implications of new minimum wage law.


Adult survival in congenital heart disease. 2. Uncommon defects with expected adult survival.


Unionization: the arbitration procedure. 2.


Outpatient services: patients' children receive care.


Adapting institutions to changing needs.


Outpatient services: pediatric patients need diversion.


High blood pressure and hospitals.

High blood pressure and hospitals.


A profile of the nursing service administrator.


Fooo service; planning for ready foods.

Fooo service; planning for ready foods.


O.R. nurse--betwixt union and management.


Preventive medicine in employee relations.


Sterilization: an enforceable right?

Sterilization: an enforceable right?


Computerized infection surveillance.

Computerized infection surveillance.


Fire safety in health care institutions.


Permissible limits for occupational exposure to toxic agents. A discussion on differences in approach between US and USSR.


The partition coefficients of styrene between blood and air and between oil and blood.


Measurement of chloral hydrate, trichloroethanol, trichloroacetic acid and monochloroacetic acid in the serum and the urine by gas chromatography.


Editorial: Fair, fat and forty.

Editorial: Fair, fat and forty.


Letter: Lower extremity monoparesis.

Letter: Lower extremity monoparesis.


Activity of glutamate decarboxylase in the brain of rats exposed to carbon disulfide.


Thirty years experience with surgery of common bile duct calculi.


Incidence of breast cancer among the Ishans of Nigeria.


Diseased gallbladder in India.

Diseased gallbladder in India.


Short stay intracapsular cataract extraction.


Coloscopy and radiology.

Coloscopy and radiology.


Epidemiological study of appendicitis in Khartoum.


Late hypoglycemia in patients following vagotomy and pyloroplasty.


Bezoar formation after vagotomy and pyloroplasty.


Choledochoduodenal fistulas.

Choledochoduodenal fistulas.


Editorial: Immune surveillance revisited.


Cell-mediated immunity and specific serum factors in human cancer: the leukocyte adherence inhibition test.


Oxidative metabolism of nicotine by cigarette smokers with cancer of the urinary bladder.


ABO blood groups and cancer.

ABO blood groups and cancer.


Rat alpha1 fetoprotein. V. Catabolism and fetal-maternal distribution.


Epidemiology of cancer of the renal pelvis and ureter.


Antigen distribution in AKR mouse leukemia.


Inhibition of melanogenesis with 5-bromodeoxyuridine treatment in a single period of DNA synthesis.


Tumor hybrid cells: an immunotherapeutic agent.


Multipotentiality of single cells of transplantable teratocarcinomas derived from mouse embryo grafts.


Congenital cutaneous and visceral melanomas of Sinclair miniature swine: three case reports.


Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by several sulfur-containing compounds.


Possible role of mucosal damage in stomach carcinogenesis with N-methyl-N-nitro-N-nitrosoguanidine in the rat.


High-virulence Marek's disease virus infection in chickens previously infected with low-virulence virus.


Inhibition by dexamethasone of intracellular binding of phorbol esters to mouse skin.


Effects of lead oxide on the induction of lung tumors in Syrian hamsters.


Chromosome banding patterns of rat fibrosarcomas induced by in vitro transformation of embryo cells or in vivo injection of rats by 7,12-dimethylbenz-(alpha)anthracene.


Modification by passive IgM of the immune response of mice to a tumor allograft.


Transplantation of a human mammary carcinoma cell line (BT 20) into nude mice.


Letter: Erroneous interpretation of valid experimental observations through interference by the LDH virus.


Activities of the Education Committee of the American Physiological Society.


Report from the Committee on Animal Care and Experimentation (American Physiological Society).


Report of the Task Force on Women in Physiology (American Physiological Society).


Proposals for changes in National Board examinations.


Basic science departments-inhibitors or catalysts? An allegorical tale.


Macroamylasemia.

Macroamylasemia.


The hostile-dependent personality. Last of a series.


Electrolytes and the electrocardiograim.


Editorial: A statement on tuberculosis.

Editorial: A statement on tuberculosis.


Painless progressive amaurosis from carotid-ophthalmic aneurysm.


Letter: Role of influenza B infections in Reye's syndrome.


Medical practice and human sexuality.

Medical practice and human sexuality.


Management of gestational diabetes.

Management of gestational diabetes.


The glucose tolerance test. An evaluation.


Intracranial hypertension.

Intracranial hypertension.


Hyperuricemia in leukemia and lymphoma.

Hyperuricemia in leukemia and lymphoma.


Studies on function and dysfunction of the masticatory system. I. An epidemiological investigation of symptoms of dysfunction in Lapps in the north of Finland.


Oral manifestations in uremia.

Oral manifestations in uremia.


Microvascular pattern of connective tissue under resorbing deciduous rabbit molar.


Permanent tooth formation of children with congenital cyanotic heart disease.


A comparative study of radiation doses received during examinations with the pantomograph, orthopantomograph, Panorex, Status-X and conventional roentgen apparatus.


Mass fragmentographic analysis of homovanillic acid and its homoiso analogue in cerebrospinal fluid using the alpha-dideutero acid as internal standard.


The effect of chlorpromazine on homovanillic acid levels in cerebrospinal fluid of schizophrenic patients.


Joint effects of sodium amylobarbitone and amphetamine sulphate on resistance to extinction of a rewarded running response in the rat.


Effects of delta9-tetrahydrocannabinol on body weight and brain electrolytes in the chicken.


Ultrastructural study of pleural fluid in mesothelioma.


Correlation between tests of small airway function.


Partitioning of the contributions of rib cage and abdomen to ventilation in ankylosING SPONDYLITIS.


Lung volumes and flow rates in black and white subjects.


Necropsy incidence of emphysema in Uganda.


Starch granules in the pericardium as a cause of the post-cardiotomy syndrome.


Clinical features of non-tuberculous constrictive pericarditis.


Sudden death in patients awaiting coronary artery surgery.


Lancefield group C streptococcal endocarditis.


Tissue typing of chimpanzees. I. Evidence for two allelic series of leukocyte antigens.


A common factor in hypertrophic osteoarthropathy.


Varicose veins and chronic venous insufficiency.


Coagulation parameters and success of thrombolytic treatment in deep vein thrombosis.


Foot-volumetry and simultaneous venous pressure measurements for evaluation of venous insufficiency.


Prevention of early post-operative deep vein thrombosis by compression of the leg during and after operation.


"Lymphatic sisyphos". Mural insufficiency of lymph drainage as a consequence of vitamin B complex deficiency.


A limitation of the Doppler ultrasound method of measuring ankle systolic pressure.


Velocity of red blood cells in human nailfold capillaries measured by a television microscopy technique.


Reflex regulation of cutaneous and muscular vessels during muscular contractions in the dog.


A vein test bench. A new instrument.

A vein test bench. A new instrument.


Preliminary observations on the clinical effect of continuous intravenous infusion of HR (O-(beta-hydroxyethyl)-rutosides) in patients with end-point lower limb ischaemia as an adjunct to oral therapy.


Automatic control of guinea-pig lice with a synergised pyrethrins aerosol.


Corkscrew penis: relapse in a bull after surgical correction.


Experimental leptospiral abortion in cattle.


The veterinarian's role in the livestock industry.


Ovine paralysis associated with spinal lesions of toxoplasmosis.


Share-Jones lecture. The backbone.

Share-Jones lecture. The backbone.


Letter: Unusual phenomenon?

Letter: Unusual phenomenon?


Partitioning of the contributions of rib cage and abdomen to ventilation in ankylosing spondylitis.


Cones block signals from rods.

Cones block signals from rods.


Visual persistence: effects of flash luminance, duration and energy.


Letter: The effect of strabismus on dichoptic summation of form information.


A technique for ERG recording in infants and young children.


Letter: Single unit activity in the rat visual cortex.


An international health conscience.

An international health conscience.


Endemic goitre and cretinism: public health significance and prevention. The information presented in this article is offered as a guide to government agencies and public health personnel on the detection of endemic goiter and cretinism, the assessment of its severity, and the initiation and monitoring of preventive programs under various field conditions.  The definition of endemic goiter is arbitrary and statistical.  Enlargement of the thyroid gland is found in all communities.  Any definition of endemic goiter implies a scale of measurement.  In general endemic goiter would be considered to exist when more than 5% of an adolescent or preadolescent group have grade 1 goiter or when more than 30% are assigned to grade Ob or above.  The following classification scheme has been found satisfactory by many observers in assessing the prevalence of abnormal thyroids:  grade Oa, thyroid not palpable, or if palpable not larger than normal; grade Ob, thyroid distinctly palpable but usually not visible with the head in a normal or raised position; grade 1, thyroid easily palpable and visible with the head in a normal position; grade 3, goiter visible at a distance; and grade 4, monstrous goiters.  The diagnosis of endemic cretinism can only be made in a population suffering from moderately severe to severe endemic goiter.  Individuals who have the classic clinical attributes of this syndrome will not be encountered unless 20% of the population has a thyroid enlargement of grade 1 or above.  Only a fraction of the total number of retarded persons in regions of severe endemic goiter conform to the textbook description of the cretin.  Most investigators maintain the opinion that the primary etiological factor is iodine deficiency.  The thyroid enlarges as a result of this deficiency, and with chronic stimulation it becomes nodular in the course of time.  If the iodine deficiency is sufficiently severe, hypothyroidism may result.  The cause or causes of endemic cretinism are less clear.  It is the consensus that endemic cretinism occurs when the fetus receives insufficient iodine.  The introduction in endemic goiter regions of iodized salt or other prophylactic agents has invariably been successful in markedly reducing the incidence of clinically significant goiter.  A 5% incidence of grade 1 goiter in preschool or periadolescent schoolchildren or a 30% incidence of goiter in the general population would warrant the development of a prophylactic program; the presence in the population of 1% of persons who could be classified as cretins would demand early and urgent action.  Methods of prevention and program implementation are reviewed.


Effect of cold hands on an emergency egress procedure.


An evaluation of two cleaning and disinfection methods of surfaces in hospital.


Decompression study and control using ultrasonics.


Progressive deterioration in short-term memory while breathing pure oxygen at normal atmospheric pressure.


Optical effects of pigmentation on temperature rise in a two-layer skin simulant system during irradiation.


Orthostatic tolerance in dehydrated, heat-acclimated men following exercise in the heat.


Changes in mesenteric, renal, and aortic flows with plusGx acceleration.


Doppler ultrasound monitoring of venous gas bubbles in pigs follwing decompression with air, helium, or neon.


Serum enzyme level changes in pigs following decompression trauma.


Effect of adrenergic drugs on pulmonary responses to high-pressure oxygen.


Feeding biorhythm alterations in heat-stressed rats.


Human factors of aircraft slide-raft combinations.


Excerpts from the casebook of Jason Harbro, M.D., AME.


Factors affecting the variability of kinetic enzyme assays.


Education costs for medical technology programs in hospital laboratories.


A survey of medical laboratory technician (MLT) programs in th United States.


Does 2 plus 2 equal 3 plus 1? A comparison of graduates from two curricula in medical technology.


Timely topics in microbiology, 1972: enteric gram negative rods.


Sepharose-bound trypsin and activated sepharose-bound trypsinogen. Studies with small and large substrates.


Nomenclature of iron-sulfur proteins (1973 recommendations). IUPAC-IUB Commission on Biochemical Nomenclature.


Dihydroorotase from rat liver: purification, properties and regulatory role in pyrimidine biosynthesis.


Folic acid deficiency and methyl group metabolism in rat brain: effects of L-dopa.


Transport of succinate by Pseudomonas putida.


Photoconversion and regeneration of active protochlorophyll(ide) in mutants defective in the regulation of chlorophyll synthesis.


Pathways of D-fructose transport in Arthrobacter pyridinolis.


Chemical modification of mitochondria. II. Effect of labeling on oxidative phosphorylation.


Purification and properties of esterase from Bacillus stearothermophilus.


On the importance of decarboxylation in the metabolism of phenylalanine, tyrosine, and tryptophan.


Conformational changes and association of chemically modified chymotrypsins.


The use of penicillocarboxypeptidase-S1 in amino acid sequencing.


Computer stimulation of sedimentation in the ultracentrifuge. VII. Solutes undergoing indefinite self-association.


Single-crystal Raman spectra of native insulin. Structures of insulin fibrils, glucagon fibrils, and intact calf lens.


On the stereospecific protonation of sulfur in biotin.


Kinetic studies of the Fe(II) oxidation with human serum ferroxidase-II.


A phospholipase A2 model system. Calcium enhancement of the amine-catalyzedmethanolysis of phosphatidylcholine.


Tyrosyl transfer ribonucleic acid synthetase from Bacillus stearothermophilus. Preparation and properties of the crystallizable enzyme.


Calorimetric determination of the heat of oxygenation of human hemolgobin as a function of pH and the extent of reaction.


Thyroid tubulin: purification and properties.


Peptide antibiotic-dinucleotide interactions. Nuclear magnetic resonance investigations of complex formation between actinomycin D and d-pGpC in aqueous solution.


Peptide antibiotic-oligonucleotide interactions. Nuclear magnetic resonance investigations of complex formation between actinomycin D and d-ApTpGpCpApT in aqueous solution.


A calorimetric study of the Bohr effect for the reaction of human hemoglobin with carbon monoxide.


Dysplastic platelets and circulating megakaryocytes in chronic myeloproliferative diseases. II. Ultrastructure of circulating megakaryocytes.


Parameters of marrow proliferative capacity in vitro: detection of a sex difference in normal human granulopoiesis.


Sodium and potassium concentration and transmembrane fluxes in leukocytes.


Recurrent attacks of abdominal pain and fever with familial segmentation arrest of granulocytes.


Interaction between rabbit erythroblast ferritin and normal plasma proteins.


Cytochemical and radioautographic identification of cells induced to synthesize hemoglobin.


The value of the serum vitamin B12 level in diagnosing B12 deficiency.


Effect of inotropic agents on the localized dyskinesis of acutely ischemic myocardium. An experimental ultrasound study.


Serum, atrial, and urinary digoxin levels during cardiopulmonary bypass in children.


Comparison of serum digoxin level measurement with acetyl strophanthidin tolerance testing.


Augmentation of left ventricular contraction pattern in coronary artery disease by an inotropic catecholamine. The epinephrine ventriculogram.


Comparison of isovolumic and ejection phase indices of myocardial performance in man.


The inotropic effects of the calcium inophore X-537A in the anesthetized dog.


Pre- and postoperative rest and exercise hemodynamics in children with pulmonary stenosis.


Necropsy studies in myocardial infarction with minimal or no coronary luminal reduction due to atherosclerosis.


Antecedents of cardiovascular disease in six Solomon Islands societies.


A sector scanner for real time two-dimensional echocardiography.


Echocardiographic features of congestive cardiomyopathy compared with normal subjects and patients with coronary artery disease.


Thrombotic calcific mitral stenosis. Morphology of the calcific mitral valve.


Unusual properties of accessory pathways.


Coronary perfusion versus cold ischemic arrest during aortic valve surgery. A randomized study.


The significance of coronary calcification detected by fluoroscopy. A report of 360 patients.


Echocardiographic detection of supravalvular aortic stenosis.


Augmentation of electrical alternans with lowering of the heart rate in massive pericardial effusion. A report of a case.


Letter: Prognostic value of ST-elevation.


Letter: Thrombosis and myocardial infarction.


Letter: The fourth heart sound.

Letter: The fourth heart sound.


Letter: Echocardiography in normal newborns.


Letter: Exercise testing in CAD.

Letter: Exercise testing in CAD.


Letter: Mitral valve prolapse.

Letter: Mitral valve prolapse.


Indexes of social organization in laboratory populations of white mice.


Letter: Vagal stimulation and VF.

Letter: Vagal stimulation and VF.


Diurnal rhythm of acid phosphatase activity in the liver of mice in cutaneous-muscular-peritoneal parabiosis.


The effect of genotype and environment on the size and number of cells in mouse organs.


Karyological investigations of two forms of Vimba vimba (Linnaeus 1758) occurring in Poland.


Morphogenesis in oxygen starved chick embryos.


Testosterone, androstenedione, and androstenediol: effects on the initiation of mating behavior of inexperienced castrated male rats.


Effects of an estrogen antagonist, MER-25, on mounting behavior and lordosis behavior in the female rat.


Lordosis behavior in castrated male rats treated with estradiol benzoate or testosterone propionate in combination with an estrogen antagonist, MER-25, and in intact male rats.


Effects of cyproterone acetate in the male Japanese quail.


Effects of hypothalamic deafferentation late in gestation on lactation and nursing behavior in the rat.


Progesterone and the ovarian-adrenal modulation of energy balance in rats.


Suppression of lordosis in guinea pigs by ethamoxy-triphetol (MER-25) given at long intervals (34-46 hr) after estradiol benzoate treatment.


Septal lesions: effects on lordosis behavior and pattern of gonadotropin release.


Independence of progesterone-induced facilitation and inhibition of lordosis behavior in ovariectomized guinea pigs.


Editorial: If I can't measure it, what do I do with it?


A detailed assessment procedure of anti-inflammatory effects of drugs on experimental immunogenic uveitis in rabbits.


Antagonism of arachidonic acid-induced ocular effects by delta1-tetrahydrocannabinol.


Asymmetric visually evoked potentials in human albinos: evidence for visual system anomalies.


Permeability of the isolated rabbit cornea to corticosteroids.


Near-ultraviolet light effects on the lenses and retinas of mice.


The dietitian in the legislative arena.

The dietitian in the legislative arena.


Serum steroid levels following a large intravenous dose of a steroid sulfate precursor during the second trimester of human pregnancy. II. Pregnenolone sulfate.


Insulin secretion in adrenergic insufficiency in man.


Report of the National Pituitary Agency. Collaborative study of the radioimmunoassay of human prolactin.


Cerebral edema in diabetic comas. II. Effects of hyperosmolality, hyperglycemia and insulin in diabetic rabbits.


Falsely positive bovine TSH radioimmunoassay responses in sera from patients with thyroid cancer.


Dissociation of growth hormone and cortisol release following apomorphine.


Disparity in the negative gonadal feedback control for LH and FSH secretion in cases of germinal aplasia or Sertoli-cell-only syndrome.


Permissive effect of testosterone on dietary adaptation of jejunal pyruvate kinase in hypogonadal males.


Unaltered plasma GH levels in acromegalics and normal men and women after administration of (Pyro)Glu-Ser-Gly-NH2, a proposed GH-releasing hormone.


Plasma insulin and glucagon responses to arginine in patients with thyroid dysfunction.


Syndrome of androgen insensitivity in man: absence of 5 alpha-dihydrotestosterone binding protein in skin fibroblasts.


Glucagon induced refractoriness to exogenous mineralocorticoid.


Academic advancement: report of a survey by the Committee on Issues, Association for Academic Surgery.


Can faculty time devoted to evaluating surgical clerks be used more effectively?


Evaluation of the fluoride ion activity electrode for determination of fluoride in potable waters, human urine and lion teeth.


Evaluation of newer techniques for the diagnosis of venous thrombosis.


The reversal of renal cortical ischemia during aortic occlusion by mannitol.


Effects of traumatic hypovolemic shock on renal function.


Fluorimetric procedure for unit dose analysis of sympathomimetic amines in pharmaceuticals.


Studies in burns. XII. Evaporative water loss is related to postburn hypermetabolism.


Hyperoxia and the red cell--a form of oxygen toxicity.


Paralyzed diaphragm--effect of plication on respiratory mechanics.


Tumor resistance in rats immunized to fetal tissues.


Urinary tract fibrinolysis.

Urinary tract fibrinolysis.


Routine birth induction in rabbits using oxytocin.


The manufacture of small quantities of rat food pellets in the laboratory.


Thyroid carcinoma of a guinea-pig: a case report.


Apparently spontaneous Candida tropicalis infection of a mouse.


Occurrence of gallstones in foetal sheep.


A case of hydrocephalus and meningoencephalocele in a rabbit, caused by aqueductal malformation.


The effects of 3 food supplements on feeding and growth rate in the rat.


Ketamine-methoxyflurane anaesthesia for the Mongolian gerbil, Meriones unguiculatus.


A technique for chronic venous cannulation in swine.


Biochemical and haematological investigations in Syrian golden hamsters after cigarette smoke inhalation.


Spinal anaesthesia in the guinea-pig.

Spinal anaesthesia in the guinea-pig.


Editorial: World Health Day--April 7.

Editorial: World Health Day--April 7.


Editorial: Mortality from carcinoma of cervix.


Aplastic anaemia in childhood. 3. Constitutional aplastic anaemia and related cytopenias.


Wasted babies or Clifford's syndrome? The effect on the developing child.


Raised serum uric acid levels with myocardial infarction.


Fat embolism: a current concept.

Fat embolism: a current concept.


Joint and soft tissue injection therapy in rheumatology.


Data communication systems in primary health care. A conceptual model.


Letter: Coeliac disease: an undiagnosed disorder with important implications.


Letter: The influence of the Royal Australasian College of Physicians on physician training and evaluation. 1.


Editorial: Problems of adolescence.

Editorial: Problems of adolescence.


The generation gap.

The generation gap.


Teenagers in limbo. The aetiology of social disorder in adolescence.


Ectopic production of the isolated alpha subunit of the glycoprotein hormones. A quantitative marker in certain cases of cancer.


Blood-volume estimates in Coombs-test-positive infants.


The effect of importing physicians--return to a pre-Flexnerian standard.


Editorial: The foreign medical graduate--a time for action.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 25-1974.


Letter: Cardiac failure: tourniquets vs. phlebotomy.


Letter: Signs and treatment of cardiopulmonary arrest.


Letter: Familial neuroblastoma: a follow-up.


Letter: Cerebral deficits after burn encephalopathy.


Letter: Citrulline for Reye's syndrome.

Letter: Citrulline for Reye's syndrome.


Letter: Cytoplasmic localization of hepatitis B surface (viral coat) antigen (HBs Ag) by electron microscopy.


Letter: Immunoelectro-osmophoresis for detection of antibody to hepatitis B core antigen.


Letter: Calcitonin in steroid-induced osteoporosis.


Letter: Gold for arthritis.

Letter: Gold for arthritis.


Letter: Drug use as determined by interviews.


Letter: Inadequate medical care for South African non-whites.


Lethal trait A 46 in cattle. Additional genetic investigations.


Preweaning mortality in pigs. 2. The perinatal period.


Thallium poisoning in red foxes (Vulpes vulpes) and badgers (Meles meles) in Denmark.


Loading with thallium among wild animals of the marten genus and badgers in Denmark.


Craniostenosis. Roentgenological and craniometric features.


Distance of upper pole calyx to spine and lower pole calyx to ureter as indicators of parenchymal loss in children.


The early diagnosis of Hirschsprung's disease.


Some factors possibly contributing to pyelonephritis at vesico-ureteral reflux.


Urographic kidney appearances secondary to upper pole resection.


Angiography and the conservative management of neonatal adrenal haemorrhage.


First rib hypoplasia in Patau's disease.


Radiological assessment of fifty patients with juvenile rheumatoid arthritis: correlation with clinical and laboratory abnormalities.


Evanescent colitis in a child.

Evanescent colitis in a child.


A simple technique for eliminating tracheal buckling on lateral neck roentgenograms.


Effect of seizures and anticonvulsant agents on hippocampal RNA concentration.


Effect of anticonvulsant drugs on the number of afferent stimuli needed to cause a hippocampal seizure discharge.


Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.


Effects of epinephrine and L-tryptophan on 3-O-methyl glucose transport into the tissues of the rat, in vivo and in vitro.


The influence of technical factors on the NBT test.


Sinus repair in the bone marrow of hypoxic mice. Possible relationship to cellular migration.


Diagnostic laparotomy in Hodgkin's disease.


Pseudotumour of bone in a haemophiliac with circulating antibodies to factor VIII. Recovery after rupture of cyst wall without necrosis or perforation of the skin.


Possible mechanism of vinblastine-induced thrombocytosis.


The role of fibrin monomer and an in vivo thrombin-induced-anticoagulant in experimental venous thrombosis.


Studies on coagulation and fibrinolysis in experimental pulmonary embolism in dogs.


AHF related protein in clinical praxis.

AHF related protein in clinical praxis.


Metamorphosis of midgut epithelial cells in the silkworm (Bombyx mori L.) with special regard to the calcium salt deposits in the cytoplasm. II. Electron microscopy.


Studies on plasma coagulation and fibrinolysis during oral contraception of various types with special reference to cold activation of factor VII. Selected coagulation and fibrinolytic factors were measured in plasma from 72 women taking oral contraceptives in a longitudinal study.  Specific pills and sampling schedules were: Anovlar (3 mg norethisterone acetate and .05 mg ethinyl estradiol, combined), taken by 40 women sampled before, after 1 and 3 weeks, and 1 week of interruption; Sequens (.1 mg mestranol and 1.5 mg  chlormadinone acetate sequential), 21 women, sampled before and after 2 and 3 weeks, and after 1 week of interruption; Ro 6-3129 (6-16-ethylthioretroprogesterone, 8-12 mg, continuously), 11 women, sampled after 1 month; additional samples  were taken after 2, 3, 5, 7, 9 and 11 months.  The pills containing estrogen affected the following parameters of the extrinsic coagulation system: thrombotest increased (p less than .001).  Cold activition (20 hours at 0 degrees C.) of factor 7 was positive in 65% of subjects after pills, but 9% before.  Estrogen pills decreased cephalin time (p less than .05), a screening test for the intrinsic coagulation system.  Factors 8 (p less than .05), IX (p less than .02), and fibrinogen (p less than .001) increased.  In the fibrinolytic system the estrogen pills increased plasminogen (p less than .001), proteolytic capacity (p less than .001) and streptokinase activated plasminogen activator (p less than .001).  Among proteinase inhibitors, antiplasmin activity (p less than .01), antithrombin 3 (p less than .001) and C'i inactivator (p less than .001) decreased.  Progestagen alone, or added in sequentials had no effect.  Since the activation of clotting factors is probably more important than increases in concentration of 1 or more factors, the increased cold activition of factor 7 was considered indicative of increased clotting tendency.


Novel features of hamster pinealocyte ultrastructure.


Studies on the initiation of protein synthesis in the course of germination of pea seeds. Quantitative changes of RNA fractions from embryo axes during initiation of germination.


Preparative separation of synthetic oligonucleotides by thin-layer chromatography on DEAE-cellulose.


Studies on hydrogen-deuterium exchange in basic trypsin inhibitor.


Characterization of DNA polymerase activity in isolated pea nuclei.


Photochemical transformation of 5-hexyluridine, and cyclobutane photoadducts of 1-hexene with uridine and 1-methyluracil.


Role of the solvent medium in the stabilization of helical poly(rU) by polyamines.


Effect of growth substances on RNA synthesis during maize seed germination.


Spring mechanisms in the human larynx.

Spring mechanisms in the human larynx.


Anatomic-radiological study of the cerebello-labyrinthine arterial system.


The fine structure of the chorioretinal border tissues of the adult human eye.


Radiological anatomy of the cistern of the internal auditory canal.


Synchronization of human tissues and its consequences for cancer therapy in ENT. Cell kinetic and clinical studies.


Decommissioning of nuclear facilities: a review of status.


Copper and the autoxidation of hemoglobin.


Characterization of an endoribonuclease from Xenopus oocytes. Possible role in ribonucleic acid turnover.


Mandelate racemase from Pseudomonas putida. Subunit composition and absolute divalent metal ion requirement.


Mandelate racemase from Pseudomonas putida. Affinity labeling of the enzyme by D,L-alpha-phenylglycidate in the presence of magnesium ion.


A thermodynamic analysis of the influence of simple mono-and divalent cations on the conformational transitions of polynucleotide complexes.


Effects of donor and acceptor peptides on concomitant hydrolysis and transfer reactions catalyzed by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R39.


Fluorescence quenching of anthracene in charged micelles by pyridinium and iodide ions.


Characterization of prostaglandin synthetase in guinea pig lung. Isolation of a new prostaglandin derivative from arachidonic acid.


Ribonucleic acid isolated by cesium chloride centrifugation.


Complexes of oligonucleotides with polynucleotides on solid supports.


The chemical synthesis and nuclear magnetic resonance spectroscopy of adenosylcobalamin selectively enriched with carbon-13.


Newly synthesized mammalian cell DNA: evidence for effects simulating the presence of RNA in the nascent DNA fraction isolated by nitrocellulose column chromatography.


Conformation of nucleosides: the comparison of an x-ray diffraction and proton nmr study of 5',2-O-cyclo, 2',3'-O-isopropylidene uridine.


Control of globin synthesis by hemin. Regulation by hemin of the formation and inactivation of a translational repressor of globin synthesis in rabbit reticulocyte lysates.


Lysine-derived crosslinks in the proteins of the human erythrocyte membrane.


Polymerization of procollagen in vitro.

Polymerization of procollagen in vitro.


Fluorescence of neurotoxins from middle-Asian cobra venom.


Isolation and characterization of subunits of human Clq.


Purification and characterization of glycine, arginine, lysine-rich and alanine, leucine, glycine-rich histones from sea urchin gonad.


Electrically induced phase transitions via the dipole model in excitable membranes.


The epileptic neuron. II.

The epileptic neuron. II.


Dynamics of populations of Biomphalaria glabrata and the Von Foerster equation.


An integral method for the analysis of flow in arterial stenoses.


A note on the shape of the erythrocyte.

A note on the shape of the erythrocyte.


Continuous determination of the volume of a space in a non steady state condition.


The simulation of multi-neurone networks: modelling of the lateral inhibition of the eye and the generation of respiratory rhythm.


Ear disease and hearing loss among the Eskimo population of the Baffin Zone.


Clinical manifestations of the Melkersson-Rosenthal syndrome.


Paediatric tracheotomy.

Paediatric tracheotomy.


Delayed decannulation--investigation and management.


On the diagnosis and management of malignant oral tumors.


Nasopharyngeal carcinoma in Eskimos.

Nasopharyngeal carcinoma in Eskimos.


A dorsal rhinotomy approach to nasal gliomas.


Inverted papilloma of the nose and paranasal sinuses.


Ceruminous adenoma of the middle ear.

Ceruminous adenoma of the middle ear.


Management of mid-face fractures.

Management of mid-face fractures.


Acute sphenoid sinusitis causing spasm of the internal carotid artery.


Sinusitis and the blind eye.

Sinusitis and the blind eye.


Report of the sub-committee on the content of the practice of otolaryngology.


Wild land: a mental health resource.

Wild land: a mental health resource.


Nursing where the people are.

Nursing where the people are.


Communicating with the aphasic patient.

Communicating with the aphasic patient.


No shift supervisors.

No shift supervisors.


Leading a child to drink.

Leading a child to drink.


Bovine abortion associated with renal oxalosis in the fetus.


Idiopathic megaesophagus in the dog: reasons for spontaneous improvement and a possible method of medical therapy.


Gastrointestinal parasites of swine in Québec. I. An incidence survey.


Hereditary pectoral myopathy in the domestic turkey (Meleagris gallopavo).


Diseases of calves admitted to a large animal clinic in Saskatchewan.


The Alberta research animal legislation.


Ultrastructure of rat pineal gland after preparation by freeze-etching technique.


Morphogenesis of the syncytium in the mouse placenta. Ultrastructural study.


Ciliogenesis and ciliary anomalies in thymic cysts of "nude" mice.


On the sexual segment of the kidney in the snake (Natric natrix).


The middle ear mucosa in the guinea pig. Distribution of ciliated epithelium and lymphatic capillaries.


Light-sensitivity of isolated pigment cells of the sea urchin Centrostephanus longispinus.


Postgraduate education.

Postgraduate education.


Treatment of rheumatoid arthritis.

Treatment of rheumatoid arthritis.


Medical ethics today.

Medical ethics today.


The clinical relevance of "pi".

The clinical relevance of "pi".


Hypotrichosis congenita hereditaria (Marie Unna).


Phenylketonuria.

Phenylketonuria.


The natural history of psoriasis in 5,600 patients.


Poikilodermatomyositis.

Poikilodermatomyositis.


Pyoderma gangraenosum.

Pyoderma gangraenosum.


Acrodermatitis chronica atrophicans (Morbus Pick-Herxheimer).


Sarcoidosis.

Sarcoidosis.


Determination of the primary structure of a mouse IgG2a immunoglobulin:amino-acid sequence of the Fc fragment. Implications for the evolution of immunoglobulin structure and function.


Comparative studies of mouse (HL-2) and human (HL-A) histocompatibility antigens.


Inhibition of horse-liver alcohol dehydrogenase by Pt(CN)4 2- and Au(CN)2-.


Structural investigations on the Salmonella T2 lipopolysaccharide.


Influence of temperature on the action of rifampicin on RNA polymerase in presence of DNA.


Purification and properties of ovalbumin messenger RNA.


Gluconeogenesis from serine by the serine-dehydratase-dependent pathway in rat liver.


Effect of central inhibition of the 1-amino acid decarboxylase on the hypotensive action of 5-HT precursors in cats.


The effect of chronically administered cannabis extract on the testicular function of mice.


Evidence for participation of catecholamines in cardiac action of ouabain. Release of catecholamines.


Interaction of d-amphetamine with central nervous system depressants on food intake and spontaneous motor activity of mice.


Comparison of central effects of 6-aminodopamine and 6-hydroxydopamine on catecholamine levels.


Gastric ulcers induced by acid accumulation and by stress in pylorus-occluded rats.


Effects of benzoquinolizine homologues on proliferative and exudative inflammation.


Benzodiazepines and barbiturates: turnover changes in central 5-hydroxytryptamine pathways.


Correlation of brain catecholamines with cortical acetylcholine outflow, behaviour and electrocorticogram.


Effect of tetrodotoxin on experimental arrhythmias.


Anti-arrhythmic effect of oxyfedrin.

Anti-arrhythmic effect of oxyfedrin.


Resolution in autoradiography using semithin sections.


Tissue-specific glucose 6-phosphate dehydrogenases in anopheline mosquitoes.


Intravenous phenolsulphophthalein test in premature infants with respiratory distress syndrome.


Congenital nasolacrimal atresia in infants--a higher incidence in primiparas.


The ocular manifestations of the cannabinols.


Calcium dobesilate as a treatment for capillary fragility in diabetic retinopathy.


Origins of time. A reconstruction of the ontogenetic development of the sense of time based on object-relations theory.


Radiation therapy with negative pions. A proposal for clinical trials.


On the statistical evaluation of dose-response functions.


Theoretical considerations on probabilities of biopolymers and life's origin.


On the enrichment of H2 18-O in the leaves of transpiring plants.


Microcalorimetric investigations of the metabolism of yeasts. IV. Effect of oxygen and hydrogen pressure on growth.


Linear and sigmoid dose-effect relations: investigations with gamma-irradiated thymine-(methyl-T) in aqueous solution and in the solid state.


Editorial: Choice of the number of sampling units in teratology.


Commentary: The statistics of teratology.


Commentary: Selection of appropriate experimental units in teratology.


Experimental modification of patterns of cell death and chondrogenesis in insulin-induced micromelia of the developing chick limb: an autoradiographic analysis of 35SO4 uptake into chondroitin sulfate.


Developmental defects in rats treated postnatally with 5-iododeoxyuridine (IUDR).


Brain cavitation and micrencephaly in lambs exposed to prenatal hyperthermia.


Teratologic effects of ethylnitrosourea on brain development in rats.


Placental transfer of diphenylhydantoin: effects of species, gestational age, and route of administration.


Leptospira and infectious canine hepatitis (ICH) virus antibodies and nephritis in Dublin dogs.


An outbreak of Hymenolepis infection in artificially reared mallard ducks.


Splenic torsion in the dog.

Splenic torsion in the dog.


Dynamic properties of the parasagittal bridging veins.


Diurnal variation of serum immunoassayable thyrotropin (TSH) concentration in the rat.


The effects of physical exercise on fat cell metabolism in the rat.


A pharmacological study of intestinal vasodilator mechanisms in the cat.


Longitudinal propagation of myogenic activity in rabbit arteries and in the rat portal vein.


The neuromuscular blocking action of an isolated toxin from the elapid (Oxyuranus scutellactus).


Effects of changes in plasma volume and osmolarity on thermoregulation during exercise.


Lactate production and anaerobic work capacity after prolonged exercise.


Changes in the concentration and fatty acid composition of phospholipids in rat skeletal muscle during postnatal development.


The influence of temperature on the force-velocity relationship in rabbit papillary muscle.


Insulin sensitivity in rats with ventromedial hypothalamic lesions.


Effect of ischemia on monoamine metabolism in the brain.


Influences on gastrointestinal and bladder motility by the fastigial nucleus.


Effect of human menopausal gonadotrophin on amino acid transport in the prepubertal rat ovary.


Letter: Dimorphism of pyrimidine bases.

Letter: Dimorphism of pyrimidine bases.


Hepatic changes after small-intestinal bypass for morbid obesity.


Evaluation of deaths from drug overdose. A clinicopathologic study.


A biochemical profile of abnormalities in hypothyroidism.


Laboratory performance of spectrophotometers. Results of a national survey.


Effect of freezing heparinized plasma on the activated partial thromboplastin time.


Detection of hypercoagulability states by a modified ethanol gelation test and its correlation with other coagulation procedures.


Rapid determination of fibrinogen by thrombokinetics.


Evaluation of an automated method for the determination of the activated partial thromboplastin time.


Letter: The clotting time--an enigma.

Letter: The clotting time--an enigma.


Letter: The N.B.T. test in cigarette smokers.


Letter: Accidental exposures to sodium azide.


Editorial: Hepatitis--the surgeons' disease.


Hemigastrectomy and truncal vagotomy in the treatment of duodenal ulcer. With a summary of related secretory data emphasizing preoperative basal acidity and postoperative basal-insulin achlorhydria.


Recurrent ulceration after gastroenterostomy or pyloroplasty with complete and incomplete vagotomy.


Profundoplasty in the treatment of femoropopliteal occlusion.


Accuracy of diagnostic tools in malignant hepatic lesions. A comparative study using serum tests, angiography, scintiscanning, and laparotomy.


Heparin and gallstones.

Heparin and gallstones.


Repair of the profunda femoris artery.

Repair of the profunda femoris artery.


Cholelithiasis in childhood.

Cholelithiasis in childhood.


Carcinoma of the large intestine in children.


Evaluation of the risk in pulmonary resection for bronchogenic carcinoma.


Insulin as the primary factor governing changes in mitochondrial metabolism leading to liver regeneration and atrophy.


Primary adenocarcinoma of the vermiform appendix.


Closed mitral commissurotomy through a midline sternotomy. A useful and potentially advantageous alternative to the left thoracotomy approach.


Oxygen and carbon dioxide tensions in the abdominal cavity and colonic wall of the rabbit.


Paroxysmal nocturnal hemoglobinuria associated with hepatic and portal venous thrombosis.


Gastrointestinal tract neoplasms with dependent hypoglycemia.


Capillary leak syndrome with massive intestinal edema after appendectomy.


Giant sigmoid diverticulum with perforation.


Spontaneous subcutaneous emphysema.

Spontaneous subcutaneous emphysema.


Improved technic for long-term venous catheterization.


Bile ptyalism in a patient with sickle cell anemia simulating bronchobiliary fistula. Conservative management.


Therapeutic bronchoscopy for the precarious patient with tracheostomy.


Diuretic-hypotensive therapy and fetal prognosis in toxaemia of pregnancy. II. Fetal prognosis after Caesarean section and conservative treatment.


The significance of one-minute Apgar scoring in evaluating the need for neonatal special care.


Measurement of fetal body dimensions by the ultrasound B-scan method.


Estimate of fetal weight from the ultrasonic measurement of the biparietal diameter and the body dimensions in normal pregnancies and pre-eclampsia.


Efficacy and safety of prostaglandin f-2-alpha as an abortifacient.


The intra-amniotic administration of prostaglandin f-2-alpha with intravenous oxytocin for the induction of midtrimester abortion.


Plasma renin activity (PRA) and some fluid equilibrium values in recumbent and upright positions in non-pregnant women and in normal and complicated term pregnancy.


Herniated lumbar disc: postoperative condition and correlation with preoperative and operative findings.


Conservative treatment of luxations and subluxations of the lower cervical spine.


Upper respiratory tract tuberculosis. Sixteen cases in a general hospital.


Plasma concentration of procainamide and prevalence of exertional arrhythmias.


Glucosephosphate-isomerase (GPI) deficiency: GPI elyria.


Letter: Indomethacin, aspirin, and urticaria.


Letter: Splitting of second heart sound at mitral area without pulmonary hypertension.


Letter: Teaching of physical diagnosis.

Letter: Teaching of physical diagnosis.


Letter: Aspirin hepatotoxicity.

Letter: Aspirin hepatotoxicity.


Letter: Heparin therapy.

Letter: Heparin therapy.


Letter: Gallium detection of inflammation.


Letter: Early hospital discharge in myocardial infarction.


Letter: Survival with respiratory failure.


Letter: Heart in rheumatoid arthritis.

Letter: Heart in rheumatoid arthritis.


Letter: Long-term gold salt therapy.

Letter: Long-term gold salt therapy.


"What is a general internist"?

"What is a general internist"?


A breakthrough in open angle glaucoma therapy.


Aphakic glaucoma.

Aphakic glaucoma.


Positive contrast orbitography: report of a complication.


Simplified binocular indirect ophthalmoscopy as a routine office procedure.


Are studies on the A-V tests helpful?

Are studies on the A-V tests helpful?


Temporal crescent or half-moon syndrome.


Enzymatic zonulolysis in cataract surgery: historical review and present use.


Management of angle-closure glaucoma.

Management of angle-closure glaucoma.


The epidemiology of suicide attempts, 1960 to 1971.


Mortality and morbidity in the first year of widowhood.


Validity of the diagnosis of primary affective disorder. A prospective study with a five-year follow-up.


Variability of the clinical course of primary affective disorder.


Psychomotor activity in affective states.


Treatment effects on the social adjustment of depressed patients.


Behavior checklist factor analysis for children and adolescents.


A Hope scale applicable to verbal samples.


Thirty severely disturbed children. Evaluation of their language development for classification and prognosis.


Pain and suffering in ischemia. The paradox of hypnotically suggested anesthesia as contradicted by reports from the "hidden observer".


Usefulness of psychiatric intervention in patients undergoing cardiac surgery.


Reliability and clinical utility of the "Wing" Present State examination.


Composition of sialoglycans isolated from Gaucher's spleen.


The combined effects of pregnanolone and porphyrinogenic agents on hepatic delta-aminolevulinic acid synthetase in mice.


Quantitative estimation of neutral and amino sugars of glycoproteins from human secretions by gas-liquid chromatography.


Effect of diazoxide in plasma glucose and insulin concentrations after acute glycemic stimulation and intravenous tolbutamide.


Modification of the competitive protein-binding assay for corticosterone: serial measurements in the rat.


Adenylate cyclase activities of the sarcotubular membranes of the genetically myopathic hamsters.


Comparative studies on human plasma monoamine oxidase in normal subjects and in fibrotic liver disease.


Arginase and xanthine oxidase activity in liver tissue in pathological conditions.


The effect of cholecystectomy on oesophageal symptoms.


Amoebic liver abscess: syndromes of 'pre-rupture' and intraperitoneal rupture.


Papilloma of the gallbladder.

Papilloma of the gallbladder.


Endoscopic retrograde cholangiopancreatography.


The solitary thyroid nodule.

The solitary thyroid nodule.


Parathyroid cyst.

Parathyroid cyst.


Antesternal pendulant goitre: a case report.


Permanent cardiac pacing through the subclavian vein.


A further comparison of the use of internal fixation and prosthetic replacement for fresh fractures of the neck of the femur.


Management of villous tumours of the rectum.


The treatment of varicose veins by compression sclerotherapy.


Chorda tympani neurectomy--a new approach to submandibular salivary obstruction.


Renal hydatid disease.

Renal hydatid disease.


Emergency surgery for calculous diseases of the upper urinary tract.


Editorial: Both sides of the fence.

Editorial: Both sides of the fence.


Editorial: Drugs for gastric ulceration.


Editorial: Angiography and carcinoma of the pancreas.


Deterioration in renal function after beta-blockade in patients with chronic renal failure and hypertension. Treatment of hypertension with beta-blocking agents in three patients with moderately severe chronic renal failure was followed by rapid deterioration of renal function. In two of the patients the need for maintenance haemodialysis was accelerated but renal function in the third reverted to pretreatment levels after the drug was stopped. These findings suggest that until more is known about the effects of beta-blocking drugs they should not be given to patients with moderately severe renal failure.


Cryosurgery for benign cervical lesions. Fifty patients with cervical erosions causing symptoms were treated with cryosurgery. Healing was complete in 41 (91%) out of 45 patients who were seen six weeks later, and in 21 patients who were followed up in greater detail the rate of symptomatic relief was high. All the patients who were treated without anaesthesia found the procedure acceptable. Only one patient noted post-operative bleeding, and this was minimal.


Respiratory symptoms in children and parental smoking and phlegm production. A study of respiratory symptoms in 2,426 schoolchildren aged 6-14 years was carried out in Aylesbury, Buckinghamshire, in 1971. The prevalence of cough in the children was associated with the parents' smoking habits; prevalence was lowest where both parents were non-smokers, highest where both parents smoked, and lay between these two levels where only one parent smoked. A close association was found between parents' and children's respiratory symptoms that was independent of parents' smoking habits. There was no suggestion that exposure to the cigarette smoke generated when parents smoked had any more than a small effect upon the child's respiratory symptoms. While the sharing of genetic susceptibility between parents and children is a factor, therefore, cross infection, particularly in the families where parents smoke, is an important element in the association.


Self-administered clinical questionnaire for outpatients. A self-administered questionnaire designed for prerecording the routine clinical information required from outpatients has been found to be acceptable to them. Such a questionnaire should greatly ease the collection and recording of basic clinical information and offer the doctor more effective use of his time. With the questionnaire more information was recorded and therefore available in the case notes than at a conventional doctor-patient consultation. No administrative problems occurred in its distribution, use, and return.


Computer-based hypertension clinic records: a co-operative study. A computer-based medical record system has been developed to help with research into hypertension and the management of patients with hypertension. Standard medical records are replaced by data collection forms and case notes printed by the computer. A computer-generated document for recording information at follow-up visits contains an up-to-date summary of the important clinical features with warnings of risk factors. A blood-pressure graph and a letter for the general practitioner are produced on request. The system has been used in three clinics for two years and is being tested in general practice. Information on 900 newly-referred patients has been recorded and at present data on 30 to 40 new patients and 160 follow-up visits are added each month.


Referees and research administrators: barriers to scientific research?


Letter: Animal experiments.

Letter: Animal experiments.


Letter: Jaundice after halothane.

Letter: Jaundice after halothane.


Letter: Dangerous patients.

Letter: Dangerous patients.


Letter: Coping with minor casualties.

Letter: Coping with minor casualties.


Letter: Effects of oral contraceptives on endogenous hormone secretion.


Letter: Contraception and abortion.

Letter: Contraception and abortion.


Letter: The "filth row".

Letter: The "filth row".


Letter: Coping with nose-bleeds.

Letter: Coping with nose-bleeds.


Letter: Death during dental anaesthesia.


Letter: Central nervous system effects of pentazocine.


Letter: Coxsackie B viruses and diabetes mellitus.


Letter: New endotracheal intubation trainer.


Letter: The solitary thyroid nodule.

Letter: The solitary thyroid nodule.


Picolinic acid hydroxylase of Arthrobacter picolinophilus.


ICMSF methods studies. 3. An appraisal of 16 contemporary methods used for detection of Salmonella in meringue powder.


Soil fungistasis: fungas spore germination in soil at spore densities corresponding to natural population levels.


Ultrastructure of root nodules formed by ineffective strains of Rhizobium meliloti.


The effect of sublethal heating on Staphylococcus aureus at different physiological ages.


Production, isolation, and antimicrobial activity of hyalodendrin, a new antibiotic produced by a species of Hyalodendron.


A phage-typing system for Salmonella newport.


Editorial: Fiberoptic and rigid bronchoscopy: the state of the art.


Editorial: Bronchoscopic perspective.

Editorial: Bronchoscopic perspective.


Bronchoscopic localization of radiographically occult lung cancer.


Bronchoscopy during mechanical ventilation using the fiberscope.


Cytology in fiberoptic bronchoscopy. Comparison of bronchial brushing, washing and post-bronchoscopy sputum.


Use of a new controllable-tip brush with the flexible fiber bronchoscope.


A study of routine cytologic screening of sputum for cancer in 800 men consecutively admitted to a tuberculosis service.


Lobar lavage: therapeutic benefit in pulmonary alveolar filling disorders.


Sinoatrial block with Wenckebach phenomenon and ventricular parasystole after myocardial infarction.


Color vectorcardiograms recorded in two unusual cases.


Spontaneous pneumothorax with unusual manifestations.


Myocardial infarction associated with coronary angiography.


Massive thrombosis associated with use of the Swan-Ganz catheter.


Sarcoidosis: the significance of an acinar pattern on chest roentgenogram.


Exit block around a junctional pacemaker.


Pulmonary pseudolymphoma presenting as a solitary nodular density with an air bronchogram.


Sarcoidosis of the larynx causing airway obstruction.


Pulmonary interstitial fibrosis following alveolar proteinosis.


Letter: The "Territorial Domain" of hemoptysis.


Letter: COPD in women in developing countries.


Periodic ordering for inventory control.


Of nursing practice and nurse practitioners.


Two hospitals share unit-dose service.

Two hospitals share unit-dose service.


Internal relations affect PR.

Internal relations affect PR.


PR events can be staged, but valid.

PR events can be staged, but valid.


Cook-freeze food service: recipe development.


Ambulatory care-medical office building facilitates inpatient, outpatient care.


Regulation in the health care system.

Regulation in the health care system.


The national blood policy.

The national blood policy.


Spirometry following glucagon and isoproterenol in chronic obstructive lung disease.


Building a data base.

Building a data base.


A hospital car pool system.

A hospital car pool system.


Therapeutic intervention scoring system: a method for quantitative comparison of patient care.


Relationship of therapy to prognosis in critically ill patients.


Too many questionnaires--and some solutions.


Health systems management, Harvard style.


Emergency medical service in the Soviet Union.


Increased hemoglobin affinity for oxygen in open heart patients.


Physicians rank hospital characteristics.


Experience with a cholinesterase histochemical technique for rectal suction biopsies in the diagnosis of Hirschsprung's disease. Cryostat sections from 160 rectal suction biopsies were stained for cholinesterases by the method of Karnovsky and Roots (1964) in an attempt to facilitate the diagnosis of Hirschsprung's disease. The method proved at least as reliable as experienced assessment of paraffin haematoxylin-eosin sections, and appeared to offer the advantages of reduced scanning fatigue and superior demonstration of the increased cholinesterase-positive nerves in Hirschprung's disease. Contrary to the findings of Meier-Ruge (1971) it was not possible to base a diagnosis on mucosal cholinesterase activity.


Malignant haemangioendothelioma involving the liver. The features of four cases of malignant haemangioendothelioma involving the liver and other organs are described. Two cases were associated with a microangiopathic haemolytic anaemia. The nature of the tumours and possible pathogenesis for the anaemias are discussed.


An automated micromethod for measuring iron concentration in serum using thioglycollic acid and bathophenantroline sulphonate. An automated micromethod for measuring iron concentration in serum employing thioglycollic acid and bathophenantroline sulphonate as reducing agent and chromogen respectively, is described. Measurements are carried out using an AutoAnalyzer (Technicon) and require 0.1 ml of sample. The reproducibility, assessed by the mean coefficient of variation (1.9%), and the mean recovery of iron added to samples (99.5%), as well as the correlation between the serum iron values estimated by the described method and the method recommended by the Expert Panel on Iron of the International Committee for Standardization in Haematology (r = 0.9779; p < 0.001; y = 0.9713 x -0.0546), is highly satisfactory. The method can also be used for measuring total ironbinding capacity of serum. The method appears equally suitable for routine work and research studies when a large number of samples and a small volume of serum are available.


The bone marrow in aplastic anaemia: diagnostic and prognostic features. Bone marrow preparations were examined from 80 patients with aplastic anaemia. The degree of cellularity varied greatly and in a third of the cases it was normal or even hypercellular at one site of aspiration. In the severely hypoplastic marrows lymphoid cells were predominant and this situation was associated with a worse prognosis. There was no correlation between marrow lymphoid cell content and blood lymphocyte count but there was an inverse relationship between blood lymphocyte count and marrow erythroblasts and a close direct relationship between the blood neutrophil count and marrow myeloid cell content. In all cases a proportion of the erythroblasts showed morphological abnormalities. These included especially megaloblastic changes and asynchrony of nuclear-cytoplasmic maturation. There were also binucleated cells, internuclear chromatin bridges, intercellular cytoplasmic connexions, nuclear degenerative changes, namely, blurred outlines, irregular shapes, budding and fragmentation, and atypical mitotic figures. These appearances illustrate the extent to which a qualitative defect of erythropoiesis occurs as part of the haematological pattern in aplastic anaemia, and in some cases dominates the bone marrow picture. Similar cytological features were found in all cases, including five patients with Fanconi's anaemia.


Cyclic thrombocytopenia: a thrombopoietin deficiency? Severe cyclic thrombocytopenia is reported in a young woman. This rare phenomenon is of considerable theoretical interest in relation to platelet kinetics. In this patient platelet and fibrinogen survival times exclude the possibility of excessive peripheral platelet destruction. Serial plasma thrombopoietin levels suggest that a deficiency of this protein may be the underlying factor. As a result platelet production may fall to a very low level. The megakaryocyte, however, remains responsive and the hypothesis advanced is that under these circumstances the intermenstrual platelet increase, normally caused by the interplay of the sex hormones, becomes grossly exaggerated.


The estimation of haemoglobin A2: is visual assessment reliable? Haemoglobin A(2) in 11 normal and 42 B thalassaemia minor subjects was estimated by simple visual assessment of the electrophoretogram. The results obtained give rise to doubts as to the reliability of this technique when used to estimate haemoglobin A(2) under normal laboratory conditions.


Heparin therapy: a simpler test of control. A bedside test of heparin activity (whole blood activated partial thromboplastin time) was assessed during clinical control of anticoagulation. It correlated closely (r = 0.94) with the whole blood clotting time but had a number of advantages.


Modification of an incident light microscope for fluorescence.


Characterization of serum inhibitors of neutrophil chemotaxis associated with anergy.


The serum factor stimulating colony formation in vitro by murine plasmacytoma cells: response to antigens and mineral oil.


Release of neutral protease and beta-glucuronidase from human neutrophils in the presence of cartilage treated with various immunologic reactants.


Inactivation of slow reacting substance of anaphylaxins (SRS-A) by arylsulfatases.


Demonstration of molecular individuality of HL-A antigens.


Induction of anti-DNP antibodies: suppressive effect of circulating anti-idiotypic antibodies to mouse myeloma protein MOPC 315.


The production of specific antibodies to native collagens with the chain compositions, (alpha1(I))3, (alpha1(II))3, and (alpha1(I))2alpha 2.


Isolation of an enzyme from Streptococcus sanguis which specifically cleaves IgA.


Cyclical changes in the ultrastructure of the normal human endometrial stromal cell.


Fetal heart rate during late pregnancy.

Fetal heart rate during late pregnancy.


The relationship between increasing birthweight and cephalopelvic disproportion in Dar Es Salaam, Tanzania.


Pregnancy after cone biopsy of the cervix.


Immediate post-termination insertion of Copper 7 and Dalkon Shield intrauterine contraceptive devices. Differences in opinion as to how long one should wait following termination of pregnancy before inserting an IUD for the most beneficial results led to the randomized study presented here.  All patients accepted for this study were having a legal termination of pregnancy and wished to use an IUD.  All were less than 12 weeks pregnant and were terminated either by Karman catheter outpatient abortion or by vacuum aspiration under a general anesthetic.  At the end of the procedure the patients were randomly inserted with either a fitted Copper 7 or the standard size Dalkon shield, 121 in each group.  A following study of 1 year was completed for 104 patients with Copper 7 and 101 patients with a Dalkon shield.  Results showed that patients fitted with IUDs at the time of termination had the same incidence of menstrual upsets, pregnancies, expulsions or removals of the IUD as patients fitted with an IUD in the nonpregnant state.  There was no difference in the complication rates of the 2 devices used at the time of termination.


Premature ovarian failure in a triple X female.


[Stake for uniform methods in the preliminary program](SWE)?


Facial analysis in patient evaluation for physiologic and cosmetic surgery.


Benign disease of the thyroid gland and vocal cord paralysis.


Cardiac complications of microsurgery of the larynx: etiology, incidence and prevention.


Dangers of succinylcholine in anesthesia.


Prevention of complications of composite resection after high dose preoperative radiotherapy.


The management of subglottic laryngeal stenosis by resection and direct anastomosis.


Schwann cell tumors of the facial nerve.


Ethacrynic acid--its reversible ototoxicity.


Localized enlargement of the thyroid gland presenting as a pyriform sinus mass.


Electrocochleography with retardates.

Electrocochleography with retardates.


An oscillographic study of an objective tinnitus.


Solubilization of molecular elements of scintillons: bioluminescent particles from dinoflagellates.


Management of malignant hypertension complicated by renal insufficiency. A follow-up study.


Progress toward a national blood system.


The biological effect of polyamines on heart RNA and histone metabolism.


Hyperthyroidism after iodinated contrast medium.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-1974.


Editorial: Neonatal intracranial hemorrhage--iatrogenic etiology?


Editorial: Immunologic mysteries of multiple sclerosis.


Committee on maternal welfare. Anesthetic death.


Letter: G-6-PD deficiency in sickle-cell disease.


Letter: Whole-blood transfusion for volume expansion.


Letter: Where is "nonparenteral"?

Letter: Where is "nonparenteral"?


Letter: HL-A antigens and psoriasis.

Letter: HL-A antigens and psoriasis.


Letter: Nasal-septum perforation in systemic lupus erythematosus.


Letter: Mannitol gives false-positive biochemical estimations of ethylene glycol.


Letter: Peritoneal dialysis via hernial sac.


Letter: Quinidine elimination in urine.

Letter: Quinidine elimination in urine.


Letter: Nature of rectosphincteric reflexes.


Letter: Aspirin and pregnancy.

Letter: Aspirin and pregnancy.


Letter: Gonorrhea in the male.

Letter: Gonorrhea in the male.


Letter: Availability of mental-hospital records.


Hypernatremia and intracranial hemorrhage in neonates.


Health education issues for the University of Nebraska Medical Center, 1973-1974.


Genotypic variations in Caucasian leukocyte estradiol 16 hydroxylase activity: a measurable determinant of breast cancer risk?


Gas infections: more than a textbook entity.


Nebraska birth defects prevention program.


Emergency transportation of the neonate.


Fetal undergrowth: relation of head growth to later intellectual performance.


Indirect plasma-theophylline monitoring in asthmatic children by determination of theophylline concentration in saliva.


Child neurology in the community hospital setting.


Primary child health care by family nurse practitioners.


The electron microscopic appearance of presecreted gastric mucus in cystic fibrosis.


Thyroid storm in an 11-year-old boy managed by propranolol.


Pneumopericardium in the newborn: diagnosis and pathogenesis.


Letter: Indian health service--by one who provides it.


Pharmacology for the pediatrician. Noncompliance contributing to apparent drug failure in status epilepticus.


Letter: Hemophilus influenzae meningitis.


Letter: Committee on Drugs attacked.

Letter: Committee on Drugs attacked.


Letter: Simple rule for converting body weight to body surface.


Urinary marking in male house mice: responses to novel environmental and social stimuli.


The effect of prior ethanol experience on ethanol-induced saccharin aversions.


Stimulus perseveration of rats with septal lesions.


Eating banana in cats for brain stimulation reward.


Alteration of pituitary-adrenal dynamics induced by a water deprivation regimen.


A simple method for studying operant wheel running in rats.


Intermittent contralateral and ipsilateral hemiretinal stimulation and its effect on the phasic stretch reflex.


A simple prefabricated electrode connector unit for chronic rat EEG studies.


Body weight and behavioral difference in mice maintained at 4C and 21C.


Caudate nucleus stimulation impairs the processes of perceptual integration.


The lack of effect of intrajugular or intraportal injections of glucose or amino-acids on food intake in pigs.


Excitability changes of the visual cortex during discrimination behavior in the cat.


Septal lesion and experiential influences on saline and saccharin preference-aversion functions.


Effects of dorsomedial thalamic lesions on spontaneous alternation, maze, activity and runway performance in the rat.


Effects of light environment on emotionality and endocrine system of inbred mice.


The ovulatory surge of gonadotropin and sexual receptivity in the female golden hamster.


A diamond knife for microsurgical repair of peripheral nerves.


Electrical stimulation of forebrain structures and its effect on copulatory as well as stimulus-bound behavior in ovariectomized hormone-primed rats.


Should the subcutaneous tissue be plicated in a face lift?


The role of steroids in prevention of circumferential capsular scarring in augmentation mammaplasty.


Patterns of the diseased fascia in the fingers in Dupuytren's contracture. Displacement of the neurovascular bundle.


Secondary correction of bilateral cleft lip deformities with Millard's midline muscular closure.


The significance of nerve involvement in leprosy.


Treatment of macromastia in the actively enlarging breast.


Experimental "blowout" fracture of the orbit.


Editorial: A plea for showing the average result.


Restoring sensation to the cut inferior alveolar nerve by direct anastomosis or by free autologous nerve grafting. Experimental study in rabbits.


Editorial: On breast tonometry.

Editorial: On breast tonometry.


Letter: On showing photographs preoperatively to patients.


Purposeful delay of cut flexor tendons in "some-man's land" in children.


Dermatofibrosarcoma protuberans or keloid--a warning. Case report.


Transmission scanning the measurement of regional ventilation: a comparison with xenon-133.


Right upper quadrant pseudotumor, a fluid-filled viscus.


Brain scintigraphy with 99mTc pertechnetate, 99mTc polyphosphate, and 67Ga citrate.


Occlusion of the posterior cerebral artery: scintiscan and angiographic findings.


Coded aperture imaging using on-axis Fresnel zone plates and extended gamma-ray sources.


Scintiphotographic demonstration of bilateral infarction in the distribution of the anterior cerebral arteries.


The pediatric pericardium.

The pediatric pericardium.


Neonatal hyperparathyroidism.

Neonatal hyperparathyroidism.


Hypertrophic osteoarthropathy and childhood Hodgkin's disease.


Contrast enhancement of pelvo-abdominal masses: the rim sign.


Local control and site of failure in radically irradiated supraglottic laryngeal cancer.


Small-field irradiation in carcinoma of the cervix, using a linear accelerator and a new beam-directing device.


Protection from chemotherapeutic epilation by prior irradiation.


Spontaneous pneumothorax as a complication of radiation therapy to the thorax.


The nonopacified gallbladder on oral cholecystography.


169Yb-equilibrium absorbed-dose constant.


Ultrasonic transmission measurements on human brain sections.


A simple method for angiography of extracorporeal arteriovenous shunts: "shunt" angiography.


Preliminary results of biopsies following irradiation for locally advanced adenocarcinoma of the prostate.


Double contrast duodenography.

Double contrast duodenography.


Adaptation of infant warmer for magnification radiography.


Is the darkroom neccessary?

Is the darkroom neccessary?


Anesthetic technique to simplify and improve bronchography in children.


Editorial: A time for change.

Editorial: A time for change.


Radiography of the lower back in pre-employment physical examinations.


Unintentional spinal cord arteriography: a warning.


Mycosis fungoides: a lymphographic assessment.


Rheumatoid arthritis of the wrist: why the ulnar styloid?


The efficacy of fine-detail radiography in the evaluation of patients with rheumatoid arthritis.


The use of methylmethacrylate in repair of neoplastic lesions in bone.


Cartilage atrophy.

Cartilage atrophy.


Fresh-water near-drowning: radiological aspects.


The low-fat meal in gallbladder examinations.


Early renal vein opacification during selective renal angiography. Trueta phenomenon or technical artifact?


Epidermal inclusion cyst of the breast associated with needle aspiration biopsy.


The incidence and causes of repeated radiographic examinations in a community hospital.


Etiology, pathogenesis, and prevention of spinal cord lesions in selective angiography of the bronchial and intercostal arteries.


Extradural cyst.

Extradural cyst.


Pneumopericardium and pneumomediastinum: rate complications of pneumoencephalography.


On factors complicating rehabilitation of psychiatric patients.


Mortality and causes of death in men found to be mentally abnormal by forensic psychiatrists.


Fatal barium intravasation during barium enema.


Morbidity among female alcoholics.

Morbidity among female alcoholics.


The kinetics of intramolecular distribution of 15N in uric acid following administration of 15N-glycine: preferential labeling of N-(3+9) of uric acid in primary gout and a reappraisal of the "glutamine hypothesis".


Hyperglutamatemia in primary gout.

Hyperglutamatemia in primary gout.


Effect of ribomononucleotides given orally on uric acid production in man.


The uptake of glycine-14C into the adenine and guanine of DNA and insoluble RNA of human leucocytes.


On the problem of hyperuricemia in certain physiological stress conditions.


Uric acid metabolism following acute myocardial infarction.


The effect of weight reduction on urate metabolism.


Diet and gout.

Diet and gout.


Relationship between gout and arterial hypertension.


Diabetes and uric acid--a relationship investigated by the epidemiological method.


Observations concerning the incidence of disturbance of lipid and carbohydrate metabolism in gout.


Metabolic and glucose load studies in uric acid, oxalic and hyperparathyroid stone formers.


Gout and hyperlipidaemia.

Gout and hyperlipidaemia.


Lipid and purine metabolism in benign symmetric lipomatosis.


An integrative hypothesis for the renal disease of urate overproduction.


Analysis of treatment results in uric acid lithiasis with and without hyperuricemia.


Isolation of a red pigment from the uric acid calculi.


Acute intratubular crystal deposition causing permanent renal damage in the pig.


Concentration of urate by differential diffusion: a hypothesis for initial urate deposition.


Experimental hyperuricemia in rats.

Experimental hyperuricemia in rats.


The binding of urate to plasma proteins.


Withdrawal of allopurinol in patients with gout.


Efficacy of single daily dose allopurinol in gouty hyperuricemia.


Effect of long-term allopurinol administration on serial GFR in normotensive and hypertensive hyperuricemic subjects.


Metabolic studies of thiopurinol in man and the pig.


Effects of allopurinol and oxipurinol on pyrimidine biosynthesis in man.


The molecular basis for the effects of allopurinol on pyrimidine metabolism.


Effects of allopurinol and oxonic acid on pyrimidine metabolism in the pig.


Ribonucleotides of allopurinol and oxipurinol in rat tissues and their significance in purine metabolism.


The effect of allopurinol on oral purine absorption and excretion in the pig.


Allopurinol and thiopurinol: effect in vivo on urinary oxypurine excretion and rate of synthesis of their ribonucleotides in different enzymatic deficiencies.


Urinary excretion of 6 hydroxylated metabolite and oxypurines in a xanthinuric man given allopurinol or thiopurinol.


Behavioural changes during adenine therapy in Lesch-Nyhan syndrome.


Acute renal failure during adenine therapy in Lesch-Nyhan syndrome.


The pig as an animal model for purine metabolic studies.


Influence of a uricosuric drug on connective tissue metabolism.


The synthesis and immuno-enhancing activity of 3-butylazathioprine.


The clinical significance of hypouricemia.


Hypouricemia, hypercalciuria and decreased bone density. A new hereditary syndrome.


Suppression of uric acid secretion in a patient with renal hypouricemia.


Evidence for a urate reabsorptive defect in patients with Wilson's disease.


Evidence for a post-secretory reabsorptive site for uric acid in man.


Reevaluation of the pyrazinamide suppression test.


Renal handling of uric acid in sickle cell anemia.


Hyperuricemia induced by ethambutol.

Hyperuricemia induced by ethambutol.


Uricosuric effect of an anticholinergic agent in hyperuricemic subjects.


Effects of benzofuran derivatives on tubular permeability to urate-2-14C in the rat nephron.


The use of high pressure liquid chromatography to monitor nucleotide levels in cells.


Development of micro HG-PRT activity assay: preliminary complementation studies with Lesch-Nyhan cell strains.


Comment on the assay of purine phosphoribosyltransferases in cultured human fibroblasts.


Significance of staining uric acid crystals with natural and synthetic dyes.


Melanoma of the mucous membranes of the head and neck.


Eustachian tube function in cleft lip and palate patients.


Auditory findings in brain stem disorders.


A critical look at the "cold calorics".

A critical look at the "cold calorics".


Salivary duct carcinoma.

Salivary duct carcinoma.