Modification of zymosan-induced release of lysosomal enzymes from human polymorphonuclear leukocytes by cytochalasin B. During the process of phagocytosis, polymorphonuclear leukocytes (PMN) release lysosomal enzymes into the extracellular medium. When the antibiotic cytochalasin B (CB) is present in the incubation medium along with phagocytable particles, enhanced recovery of enzyme activities from the incubation medium has been observed. These findings have led to the interpretation that CB enhances lysosomal enzyme release. Our results contradict this interpretation. The lysosomal enzymes acid phosphatase and beta-galactosidase are unstable after they are released from cells. During the first 5-15 min of phagocytosis, significant amounts of both acid phosphatase and beta-galactosidase can be recovered from the extracellular medium. After this, the recovery of enzyme from the medium declines, presumably because the rate of loss of lysosomal enzyme activity exceeds the rate of release at later time periods. In the presence of CB, the appearance of lysosomal enzymes in the extracellular medium of cells exposed to zymosan is retarded for 5-10 min, after which it begins and then continues for approximately 20 min. At the end of a 30-min incubation period, therefore, in the absence of CB, extracellular levels of lysosomal enzymes (especially those which are unstable) are declining toward low levels while, in the presence of CB, extracellular enzyme levels are continuing to rise. We also measured the lysosomal enzyme remaining within cells after exposure to zymosan. CB retarded the disappearance of enzyme from cells and resulted in significantly less total cell enzyme loss. Thus, in the presence of CB, a greater proportion of the lysosomal enzyme lost from cells is recovered in the extracellular medium. In contrast to the previous conclusions that CB enhances lysosomal enzyme release, our results indicate that CB delays and decreases the zymosan-stimulated release of lysosomal enzymes from PMN. Since CB inhibits phagocytosis by PMN, our results indicate that the antibiotic modifies the mechanism of release of lysosomal enzymes, resulting in zymosan stimulation of their release independently of phagocytosis.


Modified cannula for intracerebroventricular injections in conscious cats.


Molar development in the mongolian gerbil (Meriones unguiculatus).


Molecular forms and size determination of 18 S RNA from rat liver microsomes by electron microscopy.


Molecular heterogeneity of human erythropoietin.


Molecular orbital study of the conformation of histamine: the isolated molecule and solvent effect.


Modern examination methods of orbital disease. A-scan echography of the orbit.


Modern examination methods of orbital disease. Introduction.


Modern examination methods of orbital disease. Orbital radiographic tomography.


Modern examination methods of orbital disease. Orbital radionuclide examinations.


Molecular organization in bacterial cell membranes. IV. Isolation by preparative electrophoresis in sodium dodecylsulphate and properties of the two major polypeptide groups of a "soluble" fraction from Streptomyces albus membranes.


Molecular weight, shape and structure of mixed micelles of Triton X-100 and sphingomyelin.


Modern examination methods of orbital disease. Orbital ultrasonic tomography (B-scan).


Modern examination methods of orbital diseases. Selection of contrast studies of the orbit.


Molecular weights, dispersion of refractive index increments, and dimensions from transmittance spectrophotometry. Bacteriophages R17, T7, and PM2, and tobacco mosaic virus.


Molting in a parasitic nematode, Phocanema decipiens. VII. The mode of action of the ecdysial hormone.


Monitoring contamination levels of in-use intravenous solutions using "total sample" techniques.


Monoecocestus diplomys sp. n. (Cestoda: Anoplocephalidae) from the rat, Diplomys darlingi.


Monoclonal gammopathy penicillamine-induced polymyositis and systemic sclerosis.


Monosialo-lactoisohexaosyl-ceramide: a ganglioside from human spleen.


Monosynaptic corticospinal-motoneuron path in the raccoon.


Moral development research. A case study of scientific cultural bias.


Mormon fertility through half a century: another test of the Americanization hypothesis.


Morphoeic basal cell carcinoma with invasion of the orbit.


Morphine hyperglycaemia.

Morphine hyperglycaemia. 1. To find the site where morphine acts when producing hyperglycaemia on injection into the cerebral ventricles in unanaesthetized cats, morphine sulphate was infused or injected through an implanted Collison cannula into different parts of the liquor space in an amount of 0.75 mg except on microinfusion into the posterior hypothalamus, when the amounts were 80 or 160 mug. The glucose was determined in blood samples collected from the inferior vena cava.2. Microinfusions of morphine into the posterior hypothalamus did not produce hyperglycaemia.3. Infusion of morphine into the liquor space at the entrance of the aqueduct or of the fourth ventricle produced hyperglycaemia. Any structures in the walls of the third ventricle as well as the peri-aqueductal grey are thus excluded as the site of action.4. Infusion of morphine into the subarachnoid space just above the corpora quadrigemina or below the ventral surface of the brain stem produced hyperglycaemia. With these routes the morphine does not enter any part of the ventricular cavities and the action would appear to be on structures at the ventral surface of the brain stem.5. Injection of morphine into the cisterna magna produces hyperglycaemia when the doses are larger than those already effective on injection into the cerebral ventricles. This also suggests an action on structures at the ventral surface of the brain stem, as this surface is reached more readily from the ventricles than from the cisterna.6. It is concluded that on injection into the cerebral ventricles, the morphine has to pass into the subarachnoid space, through the foramina of Luschka, in order to produce hyperglycaemia. It then reaches the ventral surface of the brain stem and probably acts there on structures in the upper part of the medulla oblongata.7. Infusion of morphine into the corpora quadrigemina near the caudal end of the superior corpora can produce profound hypoglycaemia.8. Anaesthesia depresses the morphine hyperglycaemia, but when the dose injected into the cerebral ventricles is increased four times or more, hyperglycaemia is also produced in pentobarbitone sodium anaesthesia.


Morphogenetic interactions between rotated skin cuffs and underlying stump tissues in regenerating axolotl forelimbs.


Morphologic effects of 3,4',5-tribromosalicylanilide in male rats.


Morphological and chemical study of urinary calculi.


Morphological study of circulatory failure induced by a platelet aggregating factor (DAS).


Morphological, chemical, and biological characterization of Japanese encephalitis virus virion and its hemagglutinin. Three morphologically distinct structures, inner core, envelope, and surface projections, were observed in purified Japanese encephalitis virus virions by electron microscopy. The average diameter of each structure was 29.8 +/- 2.5, 44.8 +/- 3.2, and 53.1 +/- 4.5 nm, respectively. Double staining with uranyl acetate and phosphotungstic acid preserved these structures well. Treatment of virions with proteolytic enzymes resulted in the loss of hemagglutinating activity, surface projections, and the major polypeptide band in polyacrylamide gel electrophoresis, which corresponds to glycoprotein, one of the three virion polypeptides. Surface projections were purified by cesium chloride density gradient centrifugation after treatment of virions with Nonidet P-40. The purified materials had a density of 1.256 g/cm(3) and were composed of only glycoprotein, as revealed by polyacrylamide gel electrophoresis. Purified surface projections carried hemagglutinating activity, as well as neutralizing antibody-blocking activity, and induced neutralizing antibody in mice.


Morphology and life cycle of Stictodora cursitans n. comb. (Trematoda: Heterophyidae) from mammals in Florida salt marshes.


Morphological changes and quantitative topography of copper in the brain of patients with hepatic coma due to acute liver impairment.


Morphology of hereditary mouse cataract.


Morphology, hematologic parameters, and behavior of hemolymph cells of the quahaug clam, Mercenaria mercenaria.


Morphological picture of the thalamus in the newborn.


Morphometric analysis of the ultrastructural changes in the liver of aging rats.


Mortality differentials among nonwhite groups.


Mouse interferon in ascitic fluids.

Mouse interferon in ascitic fluids. Mouse interferon was obtained in relatively large volumes by the use of ascitic fluid from mice bearing sarcoma 180/TG and subsequently inoculated with Germiston virus.


Motives for drug use among light and heavy users.


Morphological changes in the nervous system and muscles in acute intermittent porphyria.


Muclear medicine.

Muclear medicine.


Multi-step mechanism in the hydrolysis of pteroylpolyglutamates by chicken intestine.


Mucosal DNA synthesis: a short term index of the trophic action of gastrin.


Mortality and the acceptability of family planning in a Haitian community.


Multiple active junctional naevi with family history of malignant melanoma.


Multinodular stenosing cardiovascular amyloidosis with involvement of the conductive tissue.


Multiphasic screening programme for somatic diseases among elderly long-term psychiatric patients.


Multiple benign gastric ulcers. A clinical and gastroscopic study.


Morphology of camel and llama erythrocytes as viewed with the scanning electron microscope.


Multiple forms of phosphorylase kinase in red and white skeletal muscle.


Multiple dose kinetics of spironolactone and canrenoate-potassium in cardiac and hepatic failure.


Multiple forms of AMP deaminase in various rat tissues.


Multiple molecular species of cytoplasmic DNA polymerase from calf thymus.


Multiple peaks in the derivative melting curve of chromatin from animals of varying age.


Multiple regression analyses of the relationship structure and inhibitory effects of a series of substituted O-phenyl-DL-homoserines on adenosine triphosphate: L-methionine S-adenosyltransferase.


Mucocele of the distal colonic segment, a late sequela of trauma to the perineum: Report of a case.


Multiple sclerosis in northern Norway.

Multiple sclerosis in northern Norway.


Multiple-species infections of intestinal helminths in Kansas coyotes.


Multivariate comparability of dissolution rates for different formulations.


Muscle injury potentials: a source of voltage in the undeformed rabbit tibia.


Murine myeloma deoxyribonucleic acid dependent ribonucleic acid polymerases. Enzyme isolation and characterization of interactions with native and denatured deoxyribonucleic acid.


Muscular dystrophy in cultured turbot (Scophthalmus maximus L).


Muscular atrophy due to glue sniffing.

Muscular atrophy due to glue sniffing.


Mutations in the CI gene of lambda bacteriophage which retain immunity and confer a rex phenotype.


Mycetoma: roentgenological findings.

Mycetoma: roentgenological findings.


Mycolic acids of representative strains of Nocardia and the 'rhodochrous' complex.


Multiple postintubation complications.

Multiple postintubation complications.


Myelomatosis with solitary cranial tumor: monostotic cranial plasmacytosis.


Myosin light-chain kinase, a new enzyme from striated muscle.


Myxosporida (Protozoa) in macrourid fishes (Coryphaenoides spp.) of the northeastern Pacific.


Myrcene: a precursor of pheromones in Ips beetles.


MCG101-AA, a new ascites tumour in C57 mice. 1. Induction procedures and some cytological and physicochemical characteristics.


MCG101-AA, a new ascites tumour in C57 mice. 2. Protocol of vivo transplantation studies in comparison with the solid (SS) and solid ascites (AS) tumours.


MCG101-AA, a new ascites tumour in C57 mice. 3. Studies of spontaneous metastasis formation from the resectable solid ascites tumour in comparison with the solid tumour of origin.


N-(2-(diethylamino)ethyl)-2-(p-hydroxyphenoxy)-acetamide, a metabolite of mefexamide in man.


N-bromosuccinimide oxidation and amino acid content of isoelectrofocused fractions from a DNP antibody population.


Narcotic antagonists administered sublingually in heroin overdoses.


N-glycosides of nitrogen-containing heterocyclic compounds. II. Studies on the structure of 2-amino-5-(3-pyridyl)-1,3,4-oxadiazole N-tetra-O-acetyl-D-glucoside.


National food and nutrition policy in the Commonwealth Caribbean.


Native fluorescence of methaqualone.

Native fluorescence of methaqualone.


Natural history of retinal breaks without detachment.


Need, not numbers: the rural HMO.

Need, not numbers: the rural HMO.


Necessity of oblique views in evaluating the functional status of a thyroid nodule.


Neolabidophorus yucatanensis gen. et sp. n. and a new record for Dermacarus ornatus Fain, 1967 (Acarina: Glycyphagidae) from Heteromys gaumeri Allen and Chapman, 1897, Gaumer's spiny pocket mouse (Rodentia: Heteromyidae).


Neoheterakis chapini n.g., n.sp. (Nematoda: Heterakoidea) from Afropavo congensis Chapin, 1936.


Neoncicola sinensis sp. n. (Acanthocephala: Oligacanthorhynchidae) from China.


Neonatal sterilization of rodents with steroid hormones. 5. A note on the influence of neonatal treatment with estradiol benzoate or testosterone propionate on steroid metabolism in the brain and testes of adult male rats.


Neoparasitylenchus amvlocercus sp. n. (Tylenchida: Nematodea) from Conophthorus monophyllae (Scolytidae: Coleoptera) in California with a synopsis of the nematode genera found in bark beetles.


Nephrotic syndrome secondary to intrinsic renal disease.


Nephrotoxicity associated with use of methoxyflurane. Recovery following severe renal impairment.


Neruopathological findings of hemifacial spasm and trigeminal neuralgia.


Neurogenic diseases of the bladder in the geriatric population.


Neurological manifestations of organophosphorous insecticide poisoning. Neurological findings are described in 200 consecutive cases of suicidal ingestion of organophosphorous insecticides. Miosis is almost universal. We found impairment of consciousness in 10%, fasciculations in 27%, convulsions in 1%, toxic delirium in 50%, and paralysis in 26%. Toxic delirium was attributed to treatment with atropine. Paralytic signs were divided into type 1 signs (present on admission) and type 2 signs (appearing later while on atropine treatment). Type 1 signs, chiefly impaired consciousness and bilateral pyramidal tract signs, respond to atropine. The most common type 2 signs are proximal limb weakness, areflexia, and cranial nerve palsies. EMG studies during type 2 paralysis show a myasthenic response in some cases. Of 36 cases with type 2 signs 15 died from respiratory paralysis after a variable period of artificial respiration. Twenty-one recovered and no residual neurological deficit has been noted. Atropine did not influence type 2 paralysis. It is claimed that type 2 signs differ significantly from those described before as `delayed neurotoxicity' and may represent an alternative mode of human toxicity with organophosphorous compounds.


Neuropsychology: an emerging specialty.

Neuropsychology: an emerging specialty.


Neurophysin-like protein in bovine pineal gland.


Neuronal activity during eye movements in a visual association area of cat cerebral cortex.


Neutral evolution and immunoglobulin diversity.


New antibiotics, methylenomycins A and B. I. Producing organism, fermentation and isolation, biological activities and physical and chemical properties.


New antibiotics, methylenomycins A and B. II. Structures of methylenomycins A and B.


New argentimetric method for semimicro estimation of some reducing drugs.


New beginnings. The Wichita State University Branch of KUMC.


New compounds: convenient selective esterification of aromatic carboxylic acids bearing other reactive groups using a boron trifluoride etherate-alcohol reagent.


New compounds: monoesters of alpha-aminobenzylphosphonic acid.


New compounds: 4-substituted 5,6-dihydro-2-o-hydroxyphenyl-4H-1,3,4-oxadiazine-5-ones, potential psychopharmacological drugs.


New demands of nurses. I.

New demands of nurses. I.


New hot plate tests to quantify antinociceptive and narcotic antagonist activities.


New method for quantitative determination of D-dopa in levodopa samples.


New observations in the clinical spectrum of the Budd-Chiari Syndrome. Some observations on the natural history, surgical management and metabolic phenomena in B.C.S. are presented. In one patient side to side portocaval shunt brought dramatic improvement with asymptomatic followup of 5 years. The patient died of causes unrelated to B.C.S. At postmortem the shunt was patent and normal liver architecture was preserved. The second patient presented with a fulminant course culminating in acute hepatorenal syndrome. There was marked hypofibrinogenemia and extreme elevation of SGOT. Emergency portocaval shunt was followed by marked improvement in liver status. The patient died of respiratory complications on the 8th postoperative day. The third patient is one year on conservative treatment only and well. In this patient excessive renal tubular reabsorption of sodium at a distal site was documented. This may explain the generalised edema formation in patients with B.C.S. even without inferior vena cava obstruction. This is apparently the first reported instance of renal tubular function studied in B.C.S.


New preparation of desmosterol.

New preparation of desmosterol.


New routes for the degradation of the lanosterol side chain.


New sampling device for the recovery of petroleum hydrocarbons and fatty acids from aqueous surface films.


New stable temporary atrial pacing loop.


New system for automatically measuring and recording blood pressure in two limbs simultaneously.


New techniques for calibrating the Lloyd-Haldane apparatus. 1. A new way of measuring the graduation error in the stem of the Lloyd-Haldane burette is described, in which a fixed mass of water is made to occupy different parts of the stem. This gave the same answer as the gravimetric method, but was much easier.2. Two independent methods of measuring the ;meniscus error' gave values of 0.006 and 0.008 ml. respectively. It is concluded that the bulb volume can be measured gravimetrically with the burette inverted, provided that the value so obtained is corrected by adding about 0.007 ml.3. Alternatively, this estimation can be made with the burette the right way up, no correction then being needed. To do this the lower end of the burette must be blocked and a method of doing this without the need to fuse on a glass tap is described.4. After calibration by the above methods analyses on fresh air for CO(2) + O(2) gave a mean value of 20.98%, which, in the authors' view, is the correct value.5. The observer error was measured and from this the theoretical maximum accuracy of gas analysis by Haldane's method was calculated. It is concluded that the calculated% should be correct to the second decimal place in about half the analyses, the rest having an error of +/- 0.01%. Results approaching this were obtained.


Nitrates and nitrites in food.

Nitrates and nitrites in food.


Nicotine-induced depression of lymphocyte growth.


Nitrates in Kansas groundwaters as related to animal and human health.


Nitrates as an environmental, animal, and human hazard.


Nitrogen determination in biological materials by the nuclear track technique.


Nitrogen retention of adult human subjects fed varying quantities of tryptophan.


Non-diagnostic prediction of behaviour and outcome in male psychiatric admissions.


Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: a clinicopathologic study. 3. Cartilaginous tumors (chondroma, chondrosarcoma).


Non-equivalence of digoxin tablets.

Non-equivalence of digoxin tablets.


Non-immunogenicity of purified hyaluronic acid preparations tested by passive cutaneous anaphylaxis.


Non-invasive measurement of cardiac output.


Non-precipitating guinea-pig antibodies produced by administration of excessive doses of ovalbumin.


Non-random circular permutation of phage P22 DNA.


Nonaggregative adherence of platelets to basal lamina in vitro.


Nonaqueous titration of methaqualone and its dosage forms.


Nonelectrolyte distribution in mouse diaphragm muscle. II. Cell volume D-xylose distribution, and the effect of insulin in hypertonic solutions.


Nonelectrolyte distribution in mouse diaphragm muscle. I. The pattern of nonelectrolyte distribution and reversal of the insulin effect.


Noonan syndrome in twins.

Noonan syndrome in twins.


Noradrenaline uptake properties of the anococcygeus muscle of the rat.


Norepinephrine and dopamine content of hypothalamic nuclei of the rat.


Nitroheterocyclic drugs as selective radiosensitizers of hypoxic mammalian cells.


Normal apparent pKa value for the ionization of the histidine residue of papain and stem bromelain as determined by photooxidation reaction.


Normal development of early human embryos: observation of 90 specimens at Carnegie stages 7 to 13.


North Dakota supreme court rules. State pharmacy ownership statute valid.


Note on the side test of Griffith and Horn.


Normothermic anoxic arrest in open-heart surgery. A preliminary report on experimental and clinical evaluation.


Notes on the geographical distribution and host preferences in the order Siphonaptera. 3. Hystrichopsyllidae.


Notes on the host-parasite relationship during infection of Praomys (Mastomys) natalensis with the filarial parasite Litomosoides carinii.


Novel classification scheme of cardiovascular tissues using trace metal compositions.


Novel synthesis of bifunctional acid-esters.


Nuclear components modifying apparent RNA polymerase activity: evidence for nuclear ribonuclease-H.


Nuclear magnetic resonance analysis of pharmaceuticals. XI. Determination of acetazolamide and its sodium salt in various dosage forms.


Nuclear magnetic resonance evidence for a Zn2-ATP complex.


Nuclear magnetic resonance studies on substrate binding to phosphoglucomutase.


Nuclear proteins of the guinea pig brain.


Normal limit of the electrogustometry test.


Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. The observation of the spin-echo decay in a long time domain has revealed that there exist at least three different fractions of non- (or slowly) exchanging water in the rat gastrocnemius muscle. These fractions of water are characterized with different nuclear magnetic resonance (NMR) relaxation times and are identified with the different parts of tissue water. The water associated with the macromolecules was found to be approximately 8% of the total tissue water and not to exchange rapidly with the rest of the intracellular water. The transverse relaxation time (T(2)) of the myoplasm is 45 ms which is roughly a 40-fold reduction from that of a dilute electrolyte solution. This fraction of water accounts for 82% of the tissue water. The reduced relaxation time is shown neither to be caused by fast exchange between the hydration and myoplasmic water nor by the diffusion of water across the local magnetic field gradients which arise from the heterogeneity in the sample. About 10% of the tissue water was resolved to be associated with the extracellular space, the relaxation time of which is approximately four times that of the myoplasm. Mathematical treatments of the proposed mechanisms which may be responsible for the reduction of tissue water relaxation times are given in this paper. The results of our study are consistent with the notion that the structure and/or motions of all or part of the cellular water are affected by the macromolecular interface and this causes a change in the NMR relaxation rates.


Nuclear transplantation from specialized and unspecialized gut epithelial cells of adult Xenopus laevis.


Nucleic acid related compounds. 12. The facile and high-yield stannous chloride catalyzed monomethylation of the cis-glycol system of nucleosides by diazomethane.


Nucleoside complexing. Interligand interactions between purine and pyrimidine exocyclic groups and polyamines. The importance of both hydrogen bonds and nonbonding repulsions.


Nucleotide polymerizing enzymes from calf thymus gland.


Nucleus dorsalis superficialis (lateralis dorsalis) of the thalamus and the limbic system in man. Although the earlier supposition was that the n. dorsalils superficialis (n. lateralis dorsalis) of the thalamus projected to the parietal region, more recent evidence has linked it to the posterior cingulate gyrus and possibly adjacent regions near the splenium of the corpus callosum. An afferent supply from lower levels was in more doubt, although some report had been made of cell and fibre degeneration in the n. dorsalis superficialis after extensive temporal resections and section of the fornix in lower primates. The five human hemispheres of the present study all had lesions of long duration below the level of the splenium of the corpus callosum in the posteromedial temporal region. All showed marked degeneration in the fornix and n. dorsalis superficialis. In favourably stained cases, gliotic fascicles could be followed from the descending column of the fornix to the n. dorsalis superficialis via the region lateral to the stria medullaris thalami. The cell loss in the nucleus thus appeared to be an instance of anterograde transynptic degeneration. These cases provided an interesting instance in which human infarctions provided natural lesions that would have been hard to duplicate in experimental animals.


Number and distribution of lymphocytes in man. A critical analysis.


Numerical analysis of absorption melting curves of a multiphase shape by a computer.


Nurse-patient therapy.

Nurse-patient therapy.


Nursing a tetraplegic patient at home.

Nursing a tetraplegic patient at home.


Nutrition and early development.

Nutrition and early development.


Nutrition in medical education.

Nutrition in medical education.


Nutrition in the education of the family physician.


Nutrition program via satellite.

Nutrition program via satellite.


Nutritional adaptation after small bowel resection in rats.


NMR investigation of histamine-phospholipid interaction.


Nutritional status of preschoolers from low-income Alabama families.


Nutritional features of Bacteroides fragilis subsp. fragilis. Studies of three reference strains of Bacteroides fragilis subsp. fragilis showed that they grow well in a minimal defined medium containing glucose, hemin, vitamin B(12), minerals, bicarbonate-carbon dioxide buffer, NH(4)Cl, and sulfide. The vitamin B(12) requirement of 0.1 ng/ml was replaced with 7.5 mug of methionine. Cysteine or sulfide was an excellent source of sulfur, thioglycolate was a poor source, and thiosulfate, methionine, beta-mercaptoethanol, dithiothreitol, sulfate, or sulfite did not serve as sole sources of sulfur. Neither single amino acids, nitrate, urea, nor a complex mixture of L-amino acids or peptides effectively replaced ammonia as the nitrogen source. Comparative studies with a few strains of other subspecies of B. fragilis including B. fragilis subsp. vulgatus, B. fragilis subsp. thetaiotaomicron, and B. fragilis subsp. distasonis indicate that they exhibit similar growth responses in the minimal medium. A single strain of B. fragilis subsp. ovatus required other materials. The results indicate the great biosynthetic ability of these organisms and suggest that, in their ecological niche within the large intestine, many nutrients such as amino acids are in very low supply, whereas materials such as ammonia, heme, and vitamin B(12), or related compounds, must be available during much of the time.


NMR investigations of the interaction of water with lecithin in benzene solutions.


O-chlorobenzylidene malononitrile (CS) and the healing of cutaneous injuries.


NMR spectra of tetracyclines: assignment of additional protons.


Observations on glucagon treatment in pancreatitis.


Observations on the effect of neuraminidase on the distribution of intravenously injected Walker tumor cells in rats.


Observations on the neotropical disk-winged bat, Thyroptera tricolor spix.


Observations on the subgenus Argas (Ixodoidea: argasidae, Argas). 8. The life cycle of A. (A.) hermanni.


Observations on the reproductive activity of chimpanzees following long-term exposure to marihuana.


Observations on violence in schizophrenia.


Observations on Bucephalus sp. parasitic in Musculista arcuatula.


Observations on Lymnaea gedrosiana, the intermediate host of Ornithobilharzia turkestanicum in Khuzestan, Iran.


Occasional correspondence: treatment of leprosy in the community.


Occasional Pacinian corpuscles at the upper part of the cat ureter.


Observations on the coeliaco-mesenteric ganglia of horses with and without grass sickness.


Occupation of father at time of birth of children dying of malignant diseases.


Occupational mortality and coronary disease.


Occurrence and distribution of acid-labile histone phosphates in regenerating rat liver.


Occurrence of antibodies to group specific chlamydia antigen in Finnish sheep, cattle and horse sera.


Occurrence of cancer in immune deficiencies.


Ochratoxicosis in the broiler chicken.

Ochratoxicosis in the broiler chicken.


Ocular evaluation of methylcellulose vehicle in albino rabbits.


Ocular surgery for traumatic injury in children.


Odontoblasts and collagen formation: an ultrastructural and autoradiographic study.


Of meetings.

Of meetings.


Oestrogen-induced endometrial hyperplasia in gonadal dysgenesis. A case report is presented of an 18 1/2-year-old girl with Turner's syndrome who developed cystic glandular endometrial hyperplasia after 4 1/2 years of .1-mg ethinyl estradiol daily for 3 out of 4 weeks per month after an initial daily  hormone dose for 9 months.  Cystic glandular hyperplasia is considered to be a precancerous lesion.  4 out of 7 other patients with dysgenetic gonads treated with ethinyl estradiol alone also showed changes of cystic glandular hyperplasia; the average duration of therapy was 3.9 years.  It is concluded that these data affirm previous evidence that prolonged, unopposed estrogenic stimulation of the endometrium has adverse effects and is an iatrogenic model of cancer induction in the endometrium.  Low-dose cyclic estrogen therapy with cyclic progesterone therapy is recommended.


On arson committed by schizophrenics.

On arson committed by schizophrenics.


On a new radiopharmaceutical for kidney imaging.


On being a volunteer.

On being a volunteer.


On biological properties of a factor(s) in extracts from tumours and rapidly growing normal tissues.


On resolution in edge-loading zonal rotors.


On measurement of basal acid output from the stomach.


On some anoplocephaline cestodes from pikas, Ochotona spp. (Lagomorpha), in Nepal, with the description of Ectopocephalium abei gen. et sp. n.


On some properties of stochastic information processes in neurons and neuron populations. Mathematical model approach.


Ocular pneumoplethysmography in carotid artery disease.


On the alkaloid composition of the snuff drug yopo from upper Orinoco (Venezuela).


On the attachment of the nuclear pore complex. Electron microscope examination of isolated rat liver nuclei after treatment with the detergent Triton X-100 revealed the complete removal of both the inner and outer membranes of the nuclear envelope. The envelope-denuded nuclei did not show any change in either shape or internal ultrastructure. Most strikingly, the nuclear pore complexes, which in untreated nuclei appear to be integral components of the nuclear envelope, were retained in their characteristic location at the distal ends of the channels leading through the peripheral heterochromatin. Determination of the chemical composition of detergent-treated nuclei showed that over 95% of the nuclear phospholipid was solubilized, thus corroborating the morphological absence of nuclear membranes. Furthermore, detergent treatment also solubilized approximately 10% of the nuclear protein. Analysis of the solubilized protein by polyacrylamide gel electrophoresis in the presence of SDS indicated that these proteins belong to a few specific classes which presumably represent the major polypeptides of the nuclear membranes. The total absence of the nuclear envelope on both morphological and biochemical grounds supports the idea that the nuclear pore complex does not require the membranes either for attachment to the nucleus or for maintenance of its own structural integrity.


On the biosynthesis of bacitracin by a soluble enzyme complex from Bacillus licheniformis.


On the chemical reactivity of aminacyl-tRNA ester bond. 3. Influence of ionic strength, spermidine and methanol on the rate of hydrolysis.


On the chemical reactivity of aminoacyl-tRNA ester bond. I. Influence of pH and nature of the acyl group on the rate of hydrolysis.


On the chemical reactivity of aminoacyl-tRNA ester bond. 2. Aminolysis by tris and diethanolamine.


On the choice of color filters for the Breathalyzer.


On the coupling of electrical events at the membranes of energized chloroplasts in intact plant leaf cells.


On the effect of amine fluoride treatment on human dental enamel.


On the essential oil of Teucrium polium L.


On the formulation of a reaction scheme for the interaction between an antigen and its antibody.


On the formation of acetyl-CoA from glutamine and the mutual interconversion between oxaloacetate and pyruvate in rabbit reticulocytes.


On the hormonal modulation of acute-phase plasma protein synthesis in perfused rat liver.


On the hypocalciuric action of chlorothiazide. Clearance experiments were performed in female mongrel dogs, either intact or thyro-parathy-roidectomized (T-PTX), under pentobarbital anesthesia, to examine the unusual hypocalciuric property of thiazide diuretics. The relationship between calcium clearance (C(Ca)) and sodium clearance (C(Na)) was determined in normal dogs, C(Ca) = 0.79 C(Na); constant infusion of chlorothiazide (CTZ) to provide drug concentrations in plasma of approximately 40 mug/ml modified this relationship; C(Ca) = 0.30 C(Na) (P < 0.001). The magnitude of the dissociating effect of CTZ on the urinary Ca/Na relationship was found to be most highly correlated with urinary drug concentration. Infusion of CTZ (1 mg/min) into one renal artery caused a unilateral decrease (25%) in C(Ca)/GFR while producing a unilateral increase (80%) in C(Na)/GFR. The same dose of CTZ in T-PTX dogs produced an increase in C(Na)/GFR without causing a change in C(Ca)/GFR. The defective response in T-PTX dogs could be ascribed to poor tubular secretion of the drug; when urinary drug concentrations were elevated in T-PTX dogs to the levels found in intact dogs (by infusing more drug), C(Ca)/GFR fell to an equivalent extent. T-PTX dogs showed substantially lower renal extraction of CTZ (42%) than intact dogs (57%); PTH administration to T-PTX dogs increased extraction toward normal (49%). The defective secretion of CTZ could not be attributed to either a decreased tubular maximum or a decreased renal blood flow.


On the intracellular distribution of polyribosomes synthesizing mitochondrial proteins.


On the mechanism of adaptation to protein synthesis inhibitors by Tetrahymena. Facilitation, cross adaptation, and resensitization. Tetrahymena is able to adapt to the presence of sublethal concentrations of many drugs which inhibit a wide variety of cellular functions. In spite of the generality of this phenomenon in Tetrahymena, the mechanism of adaptation at the cellular and molecular levels is unknown. This study deals mainly with adaptation to the protein synthesis inhibitors, cycloheximide and emetine. The physiological response of Tetrahymena to sublethal concentrations of these drugs is an immediate cessation of cell division for a period of time dependent on the drug concentration, followed by an abrupt resumption of exponential growth at a constant rate. By measuring the length of the growth lags under a variety of experimental conditions, we have confirmed several observations made by Frankel and coworkers, and provide evidence for two new phenomena associated with adaptation to cycloheximide: (a) adaptation to cycloheximide also results in adaptation of cells to emetine, another protein synthesis inhibitor not closely related structurally to cycloheximide. We have termed this phenomenon cross adaptation, (b) exposure to concentrations of cycloheximide too low to cause any growth lags or inhibition of protein synthesis significantly shortens the time required by cells to adapt to higher concentrations of cycloheximide. We have termed this phenomenon facilitation. Facilitation shows some degree of specificity in that facilitation with cycloheximide has no effect on adaptation to emetine. From this, we infer the existence of two distinct systems involved in adaptation to cycloheximide, one of which shows a higher degree of specificity towards cycloheximide than the other. We also show that transfer of adapted or facilitated cells to drug-free medium results in a gradual but complete resensitization. The kinetics of resensitization suggest that the cellular machinery responsible for adaptation and facilitation does not leave the cell, but is simply diluted out during cell division.


On the mechanism of ribonuclease A. Crystal and molecular structure of uridine 3'-O-thiophosphate methyl ester triethylammonium salt.


On the mechanism of ion exchange in crystalline zirconium phosphates. IX. The effect of crystallinity on Cs+ H+ exchange of alpha-zirconium phosphate.


On the mechanism of the release of prostaglandins E2 and F2 alpha in renal venous blood during endotoxin-hypotension.


On the mechanism of DNA replication in isolated nuclei from HeLa cells.


On the minimal size of a planarian capable of regeneration.


On the methylated purine content of tRNA present in tumours. The methylated purine content of tRNA bulk extracted from human hepatomata has been compared with that in normal human liver. The analyses were carried out with the aid of ion-exchange chromatography. The molar proportions of 5 bases detected in acid hydrolysates of tumour tRNA (N(2)-methylguanine, 1-methylguanine, 7-methylguanine, N(2)-dimethylguanine and 1-methyladenine) were not abnormally elevated.


On the mode of action of kuwaitimycin.

On the mode of action of kuwaitimycin.


On the photoactive chlorophyll reaction in system II of photosynthesis. Detection of a fast and large component.


On the rehabilitation of rheumatic heart cases: a three year study.


On the specificity of carbohydrate-lectin recognition. The interaction of a lectin from Ricinus communis beans with simple saccharides and concanavalin A.


On the specificity of neuraminidase. Synthesis of benzyl 5-acetamido-3,5-dideoxy-beta-L-arabino-heptulosidaric acid, an a-ketosidic dicarboxylic derivative of N-acetyl-D-neuraminic acid resistant to Vibrio cholerae neuraminidase.


On the stereochemistry of the interaction between nucleic acids and basic protein side chains.


On the structure of liver ribosomes.

On the structure of liver ribosomes.


On the use of p-nitroanilides as substrates for proteolytic enzymes.


On the value of lymphography before radical surgery for cervical carcinoma.


Onchocerciasis in Brazil: new findings among the Yanomama Indians.


Onset setting in inflammatory bowel disease.


Oophorectomy and radiation therapy for the breast cancer patient with early metastasis.


Open renal biopsy. New technique.

Open renal biopsy. New technique.


Open forum: A debate on the autopsy: its quality control function in medicine.


Operation S. A. F. E. (simulated aircraft fire and emergency).


Operative cholangiography. Technical aids and catheter evaluation.


Ophthalmoplegic migraine.

Ophthalmoplegic migraine.


Opium dens. A social resource for addicts in Laos.


Optimization and analytical applications of the technique dynamic introduction of liquids into centrifugal analyzers.


Optimization criteria of the mechanism governing the stability of the membrane potential.


Open canal amplification.

Open canal amplification.


Oral contraceptives and congenital limb-reduction defects.


Oral contraceptives and hypertension. A report from the Boston Collaborative Drug Surveillance Program.


Oral toxicity of azinphosmethyl in horses.


Oral glucose-stimulated insulin release in nondiabetic twin siblings of diabetic twins.


Orally administered methyldopa. Hemodynamic effects in the presence and absence of congestive heart failure.


Orbital cellulitis.

Orbital cellulitis.


Organic hydroxylamine derivatives. IX. Structural analogues of GABA of the isoxazole enol-betaine type. Improved synthesis and the crystal structure of 3-hydroxy-5-(2-aminoethyl)isoxazole zwitterion (homomuscimol).


Organization and evaluation of a physical fitness program in industry.


Organization of valve pocket thrombi and the anomalies of double thrombi and valve cusp involvement.


Organized medicine and the drug-abusing physician.


Organophosphorus compounds and carbamates as perilysosomal modifiers.


Ornithine decarboxylase activity in the uterus of the rat during early pregnancy.


Origin of the fatty acid moiety of fetal serum phospholipids in rats.


Oro-pharyngeal lesions of venereal origin.


Orthodigita: removable felt and silicone appliances for conservative treatment of hypermobility of the first segment.


Oscillatory finite amplitude supercritical equilibria induced by active stress.


Orbital vascular anomalies.

Orbital vascular anomalies.


Osmoregulation and electrolyte uptake in Antarctic nematodes.


Osmotic behaviour of human red blood cells. Effect of non-ionic detergents.


Osteochondrosis and arthrosis in pigs. VI. Relationship to feed level and calcium phosphorus and protein levels in the ration.


Osteogenesis imperfecta congenita. Report of a mother and son.


Osteoid osteoma: case presentation and discussion.


Osteological differences between water buffalo (Bos bubalis) and ox (Bos indicus). Appendicular skeleton.


Osteoma cutis.

Osteoma cutis.


Osteomalacia in welfare institutions.

Osteomalacia in welfare institutions.


Other congenital abnormalities.

Other congenital abnormalities. The plastic surgeon is not a miracle worker, as so many of his patients believe. Nevertheless, he can do much to minimize the functional and cosmetic effect of many congenital deformities. If a moral can be drawn from this article it must be that the plastic surgeon should be given an early opportunity to see and assess the patients described here, if only to ease the anxiety in the minds of their parents by appropriate reassurance and discussion.


Outcome of pregnancy after treatment of intrauterine adhesions.


Outlook for treating patients with self-destructive habits.


Outplacement physical examination.

Outplacement physical examination.


Ossicular reconstruction in effective ear disease.


Ovarian changes during gestation in pony mares.


Ovariectomy during gestation in the american opossum, Didelphis marsupialis virginiana.


Ovarian hormones and their role in aggression inhibition among male mice.


Oxalate nephrosis and crystalline myocarditis. Case report with postmortem and crystallographic studies.


Oxidation of amino acids by red and white muscle fiber groups.


Oxidation of amino acids by singlet oxygen. I. Comparison of dye sensitized photooxidation and microwave generated singlet oxidation.


OMA questions operations, methods of provincial medical review committee.


Oxytetracycline compared with single-dose therapy with sulfametopyrazine-streptomycin sulphate in nongonococcal urethritis in males.


OP tolerant cuprina.

OP tolerant cuprina.


Pacemaker treatment. Introduction.

Pacemaker treatment. Introduction.


Pacemaker treatment. II. Implantation techniques, check procedures, and management of complications.


Pacemaker treatment. IV. Epicardial and endocardial electrode systems in permanent pacemaker treatment.


Pacemaker treatment. V. Implanted pacemakers, function time, and complications.


Pacemaker treatment. 3. Endocardial electrodes in temporary pacemaker treatment.


Packaging of an oversize transducing genome by Salmonella phage P22.


Pancreatic function in malabsorbing alcoholic cirrhotics.


Papaver bracteatum Lindl: population Arya II.


Paper-strip blood-sampling technique for the detection of antibody to the plague organism Yersinia pestis. The paper-strip blood-sampling technique was evaluated for efficacy in plague passive hemagglutination tests. It is valuable for widespread serological surveys.


Papillary adenocarcinoma of the endometrium with psammoma bodies.


Parabarosis and experimental infection. 5. Effect of altered oxygen tension on Coxsackie B-1 infection in adult mice.


Parapsoriasis en plaques and mycosis fungoides.


Paracentesis as an aid to the diagnosis of abdominal disease in the horse.


Parathyroid function in the alloxan diabetic rat.


Parental adjustment to childhood leukemia.


Parental attitudes, test anxiety, and achievement motivation: a Hong Kong study.


Panel discussion: international drug regulations and their practical application. I. Swedish experience of drug regulations and their applications.


Parental expectations of a multi-disciplinary clinic for children with developmental disabilities.


Parenteral fluid therapy in septic shock: An evaluation of crystalloid and colloid. A retrospective review of 25 patients with bacteremic shock was undertaken to evaluate and compare the quality of resuscitation with infusion of either crystalloid or colloid solutions.  The average improvement in systolic pressure in the crystalloid infusion group was 23 mm of Hg, whereas the colloid group achieved a mean rise in pressure of 48 mm.  Colloid was also superior to crystalloid in terms of speed and magnitude of response measured.  In the group of 8 patients given colloid, central venous pressure was recorded over the 24-hour infusion period with a mean rise of 8 cm of water produced, vs. 2 cm of water in the crystalloid group.  Crystalloid administration aggravated arterial hypoxemia, whereas colloid infusion did not worsen respiratory function.  All 25 patients were oliguric or anuric before beginning therapy; adequate urine flow was quickly restored by expanding blood volume alone, with the fusion of a large volume of salt and water unnecessary.  Hence, it is concluded that salt solutions should not be given in cases of bacteremic shock, unless clear indications of deficits or continuing losses of sodium and water are present.  Excessive sodium administration was an unreliable and ineffective blood volume expander, accentuated hypoalbuminemia, and increased pulmonary shunting and hypoxemia.  Prompt blood pressure and central venous pressure elevation, and restoration of urine flow, can be achieved with colloid solution.


Paroxysmal dyseguilibrium in the migraine syndrome of childhood.


Partial amino acid sequence of two new arginine-serine rich histones from male gonads of the sea urchin (Parechinus angulosus).


Partial or total closure of the nostrils in atrophic rhinitis.


Partial synthesis of harringtonine analogs.


Partial purification and characterization of a muscarinic acetylcholine receptor from rat cerebral cortex.


Particle character of aminoacyl-tRNA synthetases isolated from a postmicrosomal fraction.


Partition of fatty acids.

Partition of fatty acids. The partition ratios of radioactive fatty acids between n-heptane and a physiological buffer at 37 degrees C were measured. The fatty acids included the saturated acids with an even number of carbons from 10 to 18 and the unsaturated acids oleic, linoleic, and linolenic. In addition, the partition ratios of decanoate, myristate, and palmitate were determined over a wide pH range. Any single plot of partition ratio vs. aqueous concentration of an acid gave a nearly straight line, a finding consistent with very little association in the aqueous phase. In the case of the acids with 16 and 18 carbon atoms, however, comparison of the constants calculated from these plots with the assumption of no aqueous phase association revealed several inconsistencies. These inconsistencies cannot be resolved completely by assuming the existence of fatty acid association in the aqueous solution. We believe that at least some of the deviations are due to the presence of trace quantities of radioactive impurities in the labeled fatty acids. For example, purification of a sample of supposedly pure [1-(14)C]myristate by a series of solvent extractions increased the partition ratio by a factor of 1.5. Although all of the observations cannot be explained by this interpretation, we believe that our studies suggest that there is no appreciable association of fatty acids under the usual physiological conditions.


Partition of proteins in a three-phase system.


Passage of leukocytes from mother to fetus.


Partition of trypsin in two-phase systems containing a diamidino-alpha,omega-diphenylcarbamyl poly (ethylene glycol) as competitive inhibitor of trypsin.


Pasteurella hemolytica in pullets and laying hens.


Pathologic quiz case 1.

Pathologic quiz case 1.


Pathologic quiz case 1: Papillary hyperplasia with underlying carcinoma. Pathologic quiz case 2: Inverted papilloma with squamous carcinoma.


Pathologic quiz case 2.

Pathologic quiz case 2.


Pathophysiology and care of respiratory failure.


Pathological changes in the rhesus fetus associated with the oral administration of chenodeoxycholic acid.


Pathophysiology of cestode infections: effect of Hymenolepis diminuta on oxygen tensions, pH and gastrointestinal function.


Patients as people.

Patients as people.


Patterns of oxalate metabolism in recurrent oxalate stone formers.


Paw test with syngeneic tumor cells in inbred mice bearing a transplanted sarcoma.


Patterns of the somesthetic messages transferred through the corpus callosum.


Peculiar case of "voiceprints".

Peculiar case of "voiceprints".


Peculiarities of certain .22 caliber revolvers (Saturday night specials).


Pedigree analysis to determine the mode of inheritance in a family with retinitis pigmentosa.


Patient monitoring at The Hospital for Sick Children, Toronto.


Pelvic kidney secondary to false-positive renal scan. Error in diagnosis.


Penetrating injuries of the heart.

Penetrating injuries of the heart.


Penetration of malathion in stored corn, wheat, and sorghum grain.


Peptic ulcer disease: a clinical study in 73 children. Seventy-three children with peptic ulcer have been admitted to The Montreal Children's Hospital and l'Hôpital Sainte-Justine over the past 11 years. The primary ulcer group comprised 39 duodenal and nine gastric ulcers; repeat contrast studies were necessary to demonstrate a crater in 25%. Vomiting was especially prominent in the younger patients (1 month to 6 years). Pain was present in the majority of older patients (6 to 18 years) but was considered "typical" in no more than one third. Bleeding occurred more commonly in the older children but five had occult bleeding only. There was a positive family history in 11 children with primary duodenal ulcers but in none of those with gastric ulcers. Follow-up in 34 cases with primary ulcers showed that close to two thirds of the older children have had recurrent problems. Bleeding and/or perforation was the most common mode of presentation in 25 cases of secondary ulcers. Corticosteroids and increased intracranial pressure were the most frequently associated factors, the younger age group being at greater risk.


Peptidoglycan biosynthesis by preparations from Bacillus licheniformis: cross-linking of newly synthesized chains to preformed cell wall. A wall-plus-membrane preparation from a Bacillus licheniformis mutant incorporated radioactivity from a peptidoglycan precursor in which the free amino group of diaminopimelic acid was blocked by (14)C-labelled acetyl group. This incorporation was penicillin-sensitive. The enzymically degraded product contained cross-linked dimers, showing that newly synthesized peptidoglycan chains had been cross-linked to the pre-existing cell wall.


Perceived therapy outcome as a function of differentiation between and within conceptual dimensions.


Peptidyl-puromycin synthesis on polyribosomes from rat liver or brain.


Percutaneous absorption and the surface area of occluded skin. A scanning electron microscopic study.


Patterns of Candida endocarditis following cardiac surgery: Importance of early diagnosis and therapy (an analysis of 91 cases).


Percutaneous internal jugular vein cannulation.


Peculiar disturbances of handwriting in maladie des tics.


Percutaneous penetration of some pesticides and herbicides in man.


Percutaneous needle biopsy of the lung: report of two fatal complications.


Percutaneous radiofrequency rhizotomy.

Percutaneous radiofrequency rhizotomy.


Peregrine falcon suspected of pesticide poisoning.


Perforation of the tympanic membrane, a complication of tympanic thermometry during anesthesia.


Performance on a verbal learning task by subjects of heavy past marijuana usage.


Performance testing for automated prescreening devices in cervical cytology.


Pericentriolar virus-like particles in Chinese hamster ovary cells.


Pericardial rupture from blunt chest trauma.


Perinatal care. Planning for regionalization in Kansas.


Periodontal disease in a Beagle dog colony.


Peripheral auditory function in the platypus, Ornithorhynchus anatinus.


Peripheral vitamin C metabolism in diabetics and non-diabetics: effect of intra-arterial insulin.


Peroxidase and NADPH-cytochrome C reductase activity during thyroid hyperplasia and involution.


Personality and conditioning: some personality, cognitive and psychophysiological parameters of classical appetitive (sexual) GSR conditioning.


Personality and psychological factors in postcardiotomy delirium.


Personality differences in patients with depressive illness and anxiety neurosis.


Personality variables and alpha enhancement: a correlative study.


Perspectives in urology.

Perspectives in urology.


Ph control and the "shoulder" effect in parallel fermentation pathways.


Phaeochromocytoma in a patient with primary hypogonadism and a bicuspid aortic valve.


Pharmacokinetics and distribution properties of pentobarbital in humans following oral and intravenous administration.


Pharmacokinetics and metabolism of digoxigenin-mono-digitoxoside in man.


Personality patterns and life stress in ischemic cerebrovascular disease. 1. Psychiatric findings.


Pharmacokinetics of mestranol in man in relation to its oestrogenic activity.


Pharmacokinetics of metolazone in normal subjects and in patients with cardiac or renal failure.


Pharmacokinetics of pindolol in man.

Pharmacokinetics of pindolol in man.


Pharmaceutical education in the United States of America--professional and graduate.


Pharmacokinetics of practolol in renal failure.


Pharmacokinetics of the decarboxylase inhibitor benserazide in man; its tissue distribution in the rat.


Pharmacokinetics of single and multiple doses of phenytoin in man.


Pharmacokinetics of the enantiomers of hexobarbital studied in the same intact rat and in the same isolated perfused rat liver.


Pharmacokinetics of unlabelled and 14C-labelled pindolol in uraemia.


Pharmacological examination of verruculogen induced tremor.


Pharmacological studies on the bungarotoxins: an analysis of the site of action of nicotinic agonists.


Pharmacological studies on the bungarotoxins: separation of the fractions and their neuromuscular activity.


Pharmacology of dantrolene sodium in children.


Pharmacology of the venom of the gastropod Conus magus.


Pharmacology of the venom of Conus geographus.


Pharmacology of the Pacinian receptor.

Pharmacology of the Pacinian receptor.


Phase shifts in heterochromatic flicker photometry and Bidwell's ghost: a model.


Phase 1 and phase 2 proliferative lesions of colonic epithelial cells in diseases leading to colonic cancer.


Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro. 1 A study is reported of the effects of phenytoin and phenobarbitone on bone calcium mobilization by parathyroid hormone in vitro.2 In a therapeutic concentration (15 mug/ml), phenytoin significantly inhibited parathyroid hormone-induced calcium release from bone.3 The inhibitory effect of phenytoin on bone calcium mobilization could play a role in the maintenance of hypocalcaemia in epileptic patients on long-term anticonvulsant drug therapy.


Pheromones released during inter- and intra-sex response of the scolytid beetle Dendroctonus brevicomis.


Phosphoglucomutase (PGM2) variants in Trio Indians from Surinam.


Phosphorus levels in the turkey breeder diet.


Phosphorylation of ribosomal proteins: preparation of rat liver ribosomal protein kinases. Assay of the phosphorylation of ribosomal subunit proteins. Assay of the function of phosphorylated ribosomes.


Photochemical and gamma-ray-induced reactions of nucleic acid constituents. Suppression of the reactivity of pyrimidines in the presence of purines.


Photochemical cycloadditions of triplet 1,3-dimethyluracil to olefins. Structural studies on the adducts.


Photographic analysis of human startle reaction to sonic booms.


Photometric errors in equilibrium and kinetic analyses based on absorption spectroscopy.


Photodissociation of Fe2+-CO by continuous irradiation.


Photoprotection of patients sensitive to short and-or long ultraviolet light with dihydroxyacetone-naphthoquinone.


Phylogenetic origin of xenogeneic recognition.


Phylogeny of hemoglobins: amino acid sequence of residues 35 to 92 of a viper (Vipera aspis) hemoglobin alpha-chain.


Physical and chemical characteristics and structure of carminomycin, a new antitumor antibiotic.


Physical growth at adolescence.

Physical growth at adolescence.


Physical growth characteristics in relation to sexual growth.


Physical properties and protein constituents fo cytoplasmic and mitochondrial ribosomes of Xenopus laevis.


Physical training after myocardial infarction. Metabolic effects during short and prolonged exercise before and after physical training in male patients after myocardial infarction.


Physical training in severe chronic obstructive lung disease. I. Clinical course, physical working capacity and ventilation.


Physical training in severe chronic obstructive lung disease. II. Observations on gas exchange.


Physician supply, residency programs, and the foreign medical graduate.


Physicochemical study of drug binary systems. 1. Phenobarbital-urea system.


Physicochemical study of drug binary systems. 2. Khellin-urea system.


Physiochemical properties, solubility, and protein binding of delta9-tetrahydrocannabinol.


Physiological colour changes in Odonata eyes. A comparison between eye and epidermal chromatophore pigment migrations.


Physiological dependence of brain methionine and S-adenosylmethionine concentrations on serum amino acid pattern.


Physiological responses of anxious and normal subjects to simple signal and non-signal auditory stimuli.


Physiological stimuli of growth hormone release.


Phytochemical investigation of Xanthium spinosum L.


Phytochemical investigation of Xanthium strumarium.


Phytochemotherapy II. Screening and biological assays of selected plants from the Brazilian flora.


Picture of the month: Klippel-Trenaunay-Weber syndrome (angioosteohypertrophy).


Pigments of the ocelli of Antarctic and Pacific marine nematodes.


Piroplasmosis in British badgers (Meles meles).


Pitfalls in the prenatal diagnosis of Tay-Sachs disease.


Pituitary apoplexy in acromegaly followed by partial pituitary insufficiency.


Pituitary adrenal response to ketamine and the inhibition of the response by catecholaminergic blockade.


Pituitary control of adaptation to fresh water in the teleost genus Fundulus.


Placental abnormalities of congenital syphilis. A neglected aid to diagnosis.


Pituitary function in malnutrition.

Pituitary function in malnutrition.


Placental growth modification during pregnancy in the rat.


Placental transfer of zinc in the Syrian hamster during early embryogenesis.


Placobdella multilineata (Hirudinea) from the American alligator in Florida.


Planning and evaluating blepharoplasty.

Planning and evaluating blepharoplasty.


Planning: high-pressure technique pays off.


Plant growth-promoting factor in the salivary gland of the bug, Lygus disponsi.


Plasma and blood coagulation time detector based on the flow sensitivity of self-heated thermistors.


Plasma and blood volumes in severely malnourished infants.


Plasma esterification of cholestanol, normally and in cerebrotendinous xanthomatosis.


Plasma fibrinogen levels in 1,016 regular blood donors. I. The influence of age and sex on mean values and percentiles.


Plasma growth hormone concentrations in cows before, during, and after parturition.


Plasma level profile of haloperidol in man following intramuscular administration.


Plasma levels of methotrexate in cancer patients as studied by an improved spectrophotofluorometric method.


Plasma lipid values in childhood obesity.


Plasma lithium levels and side effects during administration of a slow release lithium sulphate preparation (Lithium lipett C) and lithium carbonate tablets.


Plasma membrane-bound and lysosomal isozymes of amino acid naphthylamidase.


Plasma progesterone levels in pregnant and pseudopregnant ferrets.


Plasma LH of the prepubertal lamb: a possible early indicator of fecundity.


Platelet adhesiveness, plasma free fatty acids, and serum triglycerides in kwashiorkor.


Platelet aggregation and release by ADP and thrombin: evidence for two separate effects of ADP on platelets, involvement of fibrinogen in release, and mechanism of inhibitory action of acetylsalicylic acid.


Platelet antiheparin activity. Assay based on factor-Xa inactivation by heparin and antifactor Xa.


Platelet function long after arterial and venous thrombosis.


Playgrounds for the mentally retarded.

Playgrounds for the mentally retarded.


Pleural plaques and splenic capsular sclerosis in urban and rural series of autopsy cases.


Pneumatosis cystoides intestinalis treated by oxygen breathing.


Poisoning cases: suicide or accidents.

Poisoning cases: suicide or accidents.


Political pressures on an ailing health service.


Polarographic study of new antimicrobial pyrazolium salts. I. 1,2,5-Trimethyl-3-arylpyrazolium perchlorates.


Politics and international planning.

Politics and international planning.


Poly(U)-directed transamidation between adenosine 5'-phosphorimidazolide and 5'-phosphoadenosine 2'(3')-glycine ester.


Polyacrylamide gel electrophoresis of rat brain acetylcholinesterase: isoenzymes of normal rat brain.


Poison prevention packaging survey.

Poison prevention packaging survey.


Polymerization and depolymerization of microtubules in vitro as studied by flow birefringence.


Polymerization of optical isomers of phenylalanine N-carboxyanhydride by poly(N-methylalanine) diethylamide.


Polynucleotides. XXIV. Synthesis and properties of a dinucleoside monophosphate derived from 8,2'-O-cycloadenosine.


Polyploidization of the silk gland of Bombyx mori.


Polysubstituted pyrazoles. 1. Synthesis of 4-(4-substituted substituted sulphonamidophenylhydrazono)-2-pyrazolin-5-ones of anticipated hypoglycemic activity.


Population cytology of the genus Phaulacridium. II. Phaulacridium marginale (Walker); chiasma frequency studies from South Island, New Zealand.


Population cytology of the genus Phaulacridium. I. Phaulacridium vittatum (Sjöst): Australian mainland populations.


Porcine thyrotropin. Isolation and characterization of the hormone and its alpha and beta subunits.


Polyglycolic acid sutures in ophthalmic surgery.


Porphyrin distribution and porphyrin excretion in human congenital erythropoietic porphyria.


Porphyrin patterns in porphyria.

Porphyrin patterns in porphyria.


Position effects on interview responses.


Port health control.

Port health control. Almost 950,000 of the 21 million passengers passing through London (Heathrow) Airport in 1973 were seen by the health control unit, which is run by the London Borough of Hillingdon. The unit provides 24-hour medical cover and its responsibilities include x-ray examination for tuberculosis and screening passengers from smallpox-infected areas. It is suggested that, in view of changing epidemiological patterns throughout the world, there is a need to modify existing procedures rather than to abandon them. The development of a follow-up system for tracing passengers at risk and improvements in presenting information about health risks to intending travellers are advocated. While such proposals might be opposed, they could be practicable.


Positive-contrast peritoneography for accurate delineation of diaphragmatic abnormalities.


Possible influence of vitamin B 12-binding protein in milk on the intestinal flora in breast-fed infants. II. Contents of unsaturated B 12-binding protein in meconium and faeces from breast-fed and bottle-fed infants.


Possible involvement of 3,4-dihydroxyphenyl-acetic acid as a sclerotization agent in the American cockroach.


Post-mastectomy lymphedema.

Post-mastectomy lymphedema.


Postembryonic development of the cervicothoracic muscles of Euborellia annulipes (Lucas) (Dermaptera: Labiduridae).


Posterior pharyngeal tension pneumatocele. This unusual clinical entity is presented as a rare variant of the more common posterior pharyngeal abscess. The more important considerations discussed are: (a) the necessity for routine chest radiography in a case of "croup", including a view of the laryngeal area to rule out a foreign body; (b) the importance of routine and regular follow-up after removal of a laryngeal or esophageal foreign body, including close consultation with the radiology department; and (c) the inherent life-threatening nature of the condition and the possible need for surgical intervention on an emergency basis.


Postfracture fat embolism: a program of treatment including three case reports and review of the pertinent literature.


Posthospital adjustment of psychiatrically hospitalized drug users.


Postmenopausal bleeding.

Postmenopausal bleeding.


Postmortem changes in the cerebral free amino acid pool.


Postmortem chemistries on blood with particular reference to urea nitrogen, electrolytes, and bilirubin.


Postmortem chemistry: practical considerations and a review of the literature.


Postnatal neurogenesis in the feline cerebellum: a structural-functional investigation. The postnatal development of the feline cerebellum was analyzed and correlated with the development of balance and locomotor patterns of behavior. Three major experimental approaches were undertaken to analyze this development: (i) packing densities and linear measurements of the nodulus and uvula lobes of the archicerebellum; (ii) qualitative analysis of changes in cell composition and morphology; and (iii) behavioral observations of the development of locomotor activity. The histological analysis indicated that the external granular layers (EGL) attained its maximum thickness at 15 days followed by a rapid dissolution from this point on; concomitant with this the internal granular layers (IGL) slowly increased from birth to 60 days. Behaviorally the results showed that the 1st postnatal month was taken up with the acquisition of locomotor behavior while the 2nd postnatal month was concerned with the perfection of this behavior. Possible correlations between postnatal neurogenesis and locomotor development were discussed within the framework of brain plasticity.


Postoperative pulmonary complications in the geriatric age group.


Postprandial redistribution of regional blood flow at rest and during exercise in conscious dogs with experimental heart failure.


Postsynaptic localization of muscarinic cholinergic receptor binding in rat hippocampus.


Postsynaptic phenomena in optic tectum neurons following optic nerve stimulation in fish.


Potent bronchoconstrictor activity of 15-keto prostaglandin F2alpha.


Potent luteolytic agents related to prostaglandin F2alpha.


Practolol for sinus tachycardia in asthma.


Pre-intestinal losses of carotene in sheep fed high-starch or high-cellulose diets.


Precise determination of centromere locations.


Precise instrumental conditioned reflexes and the role of different sensory modalities in their execution in dogs. Elaboration of an instrumental reaction involving conditioned rearrangement of innate motor coordination takes a long time to attain in dogs. Particular difficulties are encountered in the execution of conditioned movement when painful stimulation evokes an inborn response opposite to the conditioned one. Exclusion of visual control of performance selectively impairs the phase of searching for the "safety zone" by the animal, whereas the ability to maintain the limb in a constant position for a long time and to carry out its correct readjustments was not affected. Exclusion of afferents from the joint led to profound and irreversible motor disturbances: along with considerable impairment of the ability to maintain the limb at a given height. Also affected were searching for the "safety zone" and the ability to carry out prompt and correct adjustments upon exposure to painful stimuli. As a result, motor reactions were accompanied by a large number of shocks when the "safety zone" was wide and could not be carried out at all when it was narrow. Forcing the animals into the unusual posture strongly disrupted the elaborated reactions: the animals were no longer able to find the "safety zone" either during the isolated action of the signal or during painful stimulation. The observed disturbances tended to progress and gradually led to the derangement of the motor habit, up to complete dropping out of the conditioned reflex component.


Predicting offender-patients' reconvictions.


Predicting participation in a screening examination for ischaemic heart disease risk factors. Experience from the Zagreb preliminary study.


Prediction of serum cholesterol.

Prediction of serum cholesterol.


Predictions of outcome in psychoanalysis and analytic psychotherapy.


Pregnancy termination in the rat "model" by a synthetic prostaglandin analogue ICI 81008.


Preliminary characterization of a binding protein for androgen in rabbit serum. Comparison with the testosterone-binding globulin (TeBG) in human serum.


Prehospital ventricular defibrillation. Prognosis and follow-up course.


Preliminary evaluation of a sex education course.


Preliminary studies on the use of n-butyl chloride as an extractant in a drug screening procedure.


Preliminary studies on the development of a swine vesicular disease vaccine.


Preliminary study of in vitro aflatoxin B 1 metabolism by human liver.


Prenatal action of growth hormone on brain and behaviour.


Preoperative radiation therapy. A plan for combined therapy by the Radiation Therapy Oncology Group and the Central Oncology Group.


Preoperative hormonal treatment in endometrial carcinoma.


Preparation and analysis of nascent chains on reticulocyte membrane-bound ribosomes.


Preparation and characterization of an inhibitor of globin synthesis from the postribosomal supernatant of reticulocyte lysates.


Preparation and characterization of free and membrane-bound polysomes.


Preparation and immunological response to a new mixed vaccine composed of inactivated Newcastle disease virus, inactivated infectious bronchitis virus, and inactivated Hemophilus gallinarum.


Preparation and properties of organophilic trypsin macro-inhibitors: diamidino-alpha, omega-diphenylcarbamyl-poly(ethylene glycol).


Preparation of a child for major surgery.


Preparation of chromatin. Variation in the template properties of chromatin dependent on the method of perparation.


Preparation of crudt tRNA and aminoacyl-tRNA synthetase from calf liver.


Preoperative use of antibiotics in colonic surgery.


Preparation of globin messenger RNA.

Preparation of globin messenger RNA.


Preparation of protein synthesis initiation factors from rabbit liver.


Preparation of protein synthesis initiation factors IF-M1, IF-M2A, and IF-M2B from rabbit reticulocytes.


Preparation of rabbit reticulocyte initiation factor IF-M3.


Preparation of reticulocyte aminoacyl-tRNA and the assay of codon recognition properties of isoacceptor tRNA's in a reticulocyte cell-free system.


Prescribing for the elderly in general practice and the problems of record keeping.


President's address: Occupational medicine and epidemiology.


President's address. The polyp-cancer sequence in the large bowel.


President's message. Inaugural Address.

President's message. Inaugural Address.


Pressure and energy in the cardiovascular chambers.


Pressures developed by loaded inspiratory muscles in conscious and anesthetized man.


Pressure measurements in the long-term follow up of peripheral vascular disease.


Presynaptic inhibition at mammalian peripheral synapse?


Prevalence and outcome of dysplasia of cervix in self-selected population of Thailand.


Prevalence of echinococcosis in reindeer (Rangifer tarandus) in Sweden.


Prevalence of selected common parasitic helminths of livestock in Kenya.


Prevalence of Au-Ag and Au-Ab in transfused children with thalassaemia in Greece.


Prevention and treatment of skin cancer.


Prevention of induced ventricular fibrillation in dogs anesthetized with ultrashort acting barbiturates and halothane.


Prevention of postoperative deep venous thrombosis in legs by orally administered hydroxychloroquine sulphate. In a series of patients given hydroxychloroquine sulphate by mouth before and after major surgery the incidence of deep venous thrombosis in the legs, as assessed by iodine-125-tagged fibrinogen scanning and venography, was reduced to 5% compared with an incidence of 16% in a similar untreated group of patients.


Preventive measures to obtain Salmonella-free slaughter pigs.


Primary adrenal and ovarian failure.

Primary adrenal and ovarian failure.


Primary affective disorders. Selection efficiency of two sets of diagnostic criteria.


Primary malignant melanoma of the oral cavity in Japan. With special reference to mucosal melanosis.


Primary melanoma of the esophagus.

Primary melanoma of the esophagus.


Primary ovarian pregnancy: presentation of ten cases, including one full-term pregnancy.


Primary pericardial mesothelioma.

Primary pericardial mesothelioma.


Primary seminoma of the mediastinum.

Primary seminoma of the mediastinum.


Primary thymic Hosgkin's disease. A clinicopathologic study of 27 cases.


Prinzmetal angina with transient complete heart block.


Probe-tone frequency and the diagnostic value of tympanometry.


Problem-oriented Community Cancer Care.

Problem-oriented Community Cancer Care.


Problem families.

Problem families.


Problems in heart rate and alpha electroencephalographic feedback. Is the control over the feedback stimulus meaningful?


Problems in the treatment of endometrial carcinoma.


Problems of minor injuries in general practice.


Procaine (Gerovital H3) therapy: mechanism of inhibition of monoamine oxidase.


Proceedings: A 'bootstrap' model of water conservation by juxta medullary (JM) nephrons.


Proceedings: A clinician's view of modelling and simulation.


Proceedings: A correlation method of dynamic analysis used for the estimation of a dose-response curve.


Proceedings: A comparison of the effect of a reduction in maternal blood flow on the placental transfer of glucose and amino nitrogen from mother to foetus.


Proceedings: A new method of plotting the receptive field profiles of visual cortical neurones using an electronic stimulator.


Proceedings: A potassium ion-selective liquid membrane.


Proceedings: A quantitative assessment of the effects of clonidine on pre-ganglionic sympathetic nerve activity in the cat.


Proceedings: A tracer method for predicting the long-term therapeutic response in bone wasting diseases.


Proceedings: A study of the control of the hypothalamo-pituitary-Leydig cell axis: the role of oestradiol in the feed-back of exogenously administered androgen.


Proceedings: A two-state (allosteric) model for sodium channels in transporting epithelia.


Proceedings: Activation of intramural inhibitory neurones of the rabbit caecum by nicotine.


Proceedings: An antibody to vasopressin in man.


Proceedings: An endocrine exocrine interaction in the isolated canine pancreas.


Proceedings: Cardiac responses to diving in trained dogs.


Proceedings: Cerebral rhabdomyosarcoma.

Proceedings: Cerebral rhabdomyosarcoma.


Proceedings: Convergence in a thermal afferent pathway.


Proceedings: CSF in acute childhood leukaemia: cytocentrifuge studies.


Proceedings: Dental care for the cancer patient.


Proceedings: Detection and diagnosis of oral malignancies.


Proceedings: Development of a breathing model of the respiratory system.


Proceedings: Direct measurement of image quality in the cat eyes.


Proceedings: Disordered brain development in small-for-dates infants.


Proceedings: Dynamic modelling of respiratory gas exchange for clinical applications.


Proceedings: Distribution of tooth receptor afferents in the mesencephalic nucleus of the fifth cranial nerve.


Proceedings: Effect of electrode positions on contractions of guinea-pig isolated ileum to electrical stimulation.


Proceedings: Effect of fenfluramine and norfenfluramine on glucose uptake by the isolated rat diaphragm.


Proceedings: Effects of an acute diuresis on cardio-pulmonary function in oedematous chronic bronchitics.


Proceedings: Effect of oestrogens and progesterone alone and in combination on the female rat plasma kininogen concentrations.


Proceedings: Effects of quazodine on cat fast- and slow-contracting skeletal muscles.


Proceedings: Effects of some clinically used anaesthetics on the enzymes of gamma-aminobutyric acid metabolism.


Proceedings: Effects of stress during pregnancy on plasma corticosterone levels and foetal development in the mouse.


Proceedings: Endotoxaemia in fulminant hepatic failure.


Proceedings: Evidence for active transport of the tripeptide glycylsarcosylsarcosine by hamster jejunum in vitro.


Proceedings: Force:velocity properties of cross-innervated cat muscles.


Proceedings: Factors contributing to the binding of (3H)-5-hydroxytryptamine to butanol extracts of rat brain.


Proceedings: Hypothermia produced by inhibitors of catecholamine biosynthesis.


Proceedings: In vitro study of the kinetics of transport of 125I albumin from serum to arterial wall.


Proceedings: Increased inactivation of prostaglandin E2 by the rabbit lung during pregnancy.


Proceedings: Inhibition by prostaglandins of fluid transport in the isolated gallbladder of the guinea-pig.


Proceedings: Inhibition of collagen-induced platelet aggregation by aspirin.


Proceedings: Interstitial pulmonary emphysema in the newborn.


Proceedings: Lipidosis-like ultrastructural alterations in rat tissues induced by an antidepressant drug (iprindole).


Proceedings: Mental health in children: education and prevention.


Proceedings: Mechanism of the early pressor effect of centrally administered propranolol in the conscious rabbit.


Proceedings: Motoneurone field potential responses to iontophoretically applied 5-hydroxytryptamine.


Proceedings: Motor units of cross-reinnervated fast and slow twitch muscles.


Proceedings: Multi-barrelled micropipettes with improved recording characteristics.


Proceedings: Myocardial infarction in the newborn.


Proceedings: Na-Na exchange in guinea-pig taenia coli.


Proceedings: Necrosis of vocal cords in infants.


Proceedings: Oestrogen dependence of enzyme activity and intracellular structure in the hamster submaxillary gland.


Proceedings: Paediatric dosage of gentamicin.


Proceedings: Partial separation of retinal subcellular particles accumulating labelled gamma-aminobutyric acid (GABA) at high and low concentrations.


Proceedings: Potentiation and antagonism of neuronal responses to monoamines by methysergide and sotalol.


Proceedings: Preliminary studies of pure human pancreatic secretions collected via the duodenoscope.


Proceedings: Pressure changes in the oesophagus of sheep during rumination.


Proceedings: Potentiation by prostaglandin E1 and arachidonic acid of oedema in the rat paw induced by various phlogogenic agents.


Proceedings: Potentiation by prostaglandins of the nociceptive activity of bradykinin in the dog knee joint.


Proceedings: Pulmonary reticulosis.

Proceedings: Pulmonary reticulosis.


Proceedings: Prosthetic rehabilitation of the head and neck cancer patient.


Proceedings: Quantitative studies on acetylcholine receptors of the isolated iris sphincter muscle.


Proceedings: Reduction of prostaglandin E2 to prostaglandin F2 aplha by an enzyme in sheep blood.


Proceedings: Renal hypertrophy after unilateral ureterophlebostomy in the rat.


Proceedings: Regional distribution of glutamate and gamma-aminobutyric acid and their associated enzymes in the frog central nervous system.


Proceedings: Screening for abnormal haemoglobins in the immigrant community.


Proceedings: Significance of 'focal sclerosis' in lipoid nephrosis.


Proceedings: Simple teaching and research methods for measuring the properties of membranes.


Proceedings: Some observations upon the determination of capillary filtration coefficient (CFC) in the innervated small intestine of the anaesthetized cat.


Proceedings: Spontaneous rupture of the aorta in a 13-year-old boy.


Proceedings: Supernormal conduction velocity in the olfactory nerve of the tortoise.


Proceedings: Surgical advances in rehabilitation of the laryngectomee.


Proceedings: Synchronized firing of respiratory motoneurones during spontaneous breathing in the anaesthetized cat.


Proceedings: Systems analysis and the glucose-insulin control system.


Proceedings: The binding affinity of an alkylating muscarinic agonist: acetylcholine mustard.


Proceedings: The choice of an index of antidiuretic response.


Proceedings: The dependence of the respiratory fluctuation in chemoreceptor afferent discharge on tidal volume and respiratory rate in the cat.


Proceedings: The diuretic and natriuretic effects of arterial infusions of substance P and their relationship to kallikrein excretion.


Proceedings: The effect of mescaline on defaecation in seven inbred strains of laboratory mice.


Proceedings: The effect of morphine on the choline acetyltransferase population of rat caudate nucleus.


Proceedings: The effect of norfenfluramine on thermoregulation in the rabbit.


Proceedings: The heterogeneity of goldfish brain and muscle choline acetyltransferase.


Proceedings: The effects of RX 336M and RX 5050M on tests for antidepressant activity in mice.


Proceedings: The in vitro effects of vinblastine on the nerve-mediated responses of the guinea-pig vas deferens.


Proceedings: The in vitro rat cervix.

Proceedings: The in vitro rat cervix.


Proceedings: The nature of the tryptamine receptor mediating spasmogen release from rat isolated lungs.


Proceedings: The noradrenaline concentration and the cholinesterase activity of the separated longitudinal and circular layers of muscle of the guinea-pig vas deferens.


Proceedings: The present state of immunological modelling.


Proceedings: The relationship of ascorbic acid to leptazol-induced convulsions in guinea-pigs.


Proceedings: The release of (14C)-taurine from slices of rat cerebral cortex and spinal cord evoked by electrical stimulation and high potassium ion concentrations.


Proceedings: The respiratory response to intravenous infusion of hypercapnic blood in the anaesthetized rabbit.


Proceedings: The role of the duodenal infusate on gastric emptying measured by the e.m.g. of gastric muscle.


Proceedings: The role of brain dopamine in the hyperactivity syndrome produced in rats after administration of L-tryptophan and a monoamine oxidase inhibitor.


Proceedings: The surface membrane of human placental villi and aspects of its possible role in the foeto-maternal relationship.


Proceedings: Towards an isomorphic model of glucose metabolism.


Proceedings: Uptake of propranolol by the isolated perfused rat liver.


Proceedings: Two cases of neuroblastoma with marrow findings mimicking acute leukaemia.


Proceedings: Vagal afferent nerve endings in the gastric antral mucosa of the rat.


Proceedings: 2-2' pyridylisatogen tosylate: an antagonist of the inhibitory effects of ATP on smooth muscle.


Proctosigmoidoscopy and polypectomy in reducing the incidence of rectal cancer.


Production of enniatins by Fusarium sambucinum: selection of high-yield conditions from liquid surface cultures.


Production of anti-H-2 antibodies in thymectomized mice.


Production of paroxysmal nocturnal haemoglobinuria-like red cells by reducing and oxidizing agents.


Products containing aspirin.

Products containing aspirin.


Profound muscle weakness associated with axis cylinder ballooning. A case report.


Progesterone and oestradiol-17beta concentrations in the peripheral plasma during pregnancy in the mouse.


Prognosis in schizophrenia.

Prognosis in schizophrenia.


Prognosis in severe chronic obstructive pulmonary disease. Relation to degree of obstruction, age and sex and electrocardiographic changes suggesting cor pulmonale.


Prognosis of asymptomatic retinal breaks.


Program monitors all services.

Program monitors all services.


Programmed investigation unit.

Programmed investigation unit.


Progressive haematoma of the ethmoid region in the horse.


Programmed treatment of ruptured appendicitis in children.


Proline in fascioliasis: I. Comparative activities of ornithine-delta-transaminase and proline oxidase in Fasciola and in mammalian livers.


Promoting safety.

Promoting safety.


Properties and use of invertase entrapped in fibers.


Properties of a calcium channel in snail neurones.


Properties of a Ca2+ binding peptide from prothrombin.


Properties of acetylcholinesterase from rat brain.


Properties of basic amino-acid residues. Nucleotide--poly(amino acid)interaction.


Properties of diastereoisomeric photohydrates of uracil nucleosides.


Properties of small neural networks.

Properties of small neural networks.


Properties of warm receptors in boa constrictor.


Prophylactic cryoretinopexy of retinal breaks.


Propylene glycol as a drug solvent in the study of hepatic microsomal enzyme metabolism in the rat.


Prostaglandin A1 in hypertensive crisis.


Prospective study on the occurrence and management of chronic sinoatrial disease, with follow-up.


Prostaglandin-induced ovarian ascorbic acid depletion.


Prostaglandin E2 and LH release in ovariectomized rats.


Prostaglandins and gonadotropin secretion.


Prostaglandins of E series and LH release in fertile male rats.


Prostaglandins of the E and F series in rabbit cerebrospinal fluid during fever induced by Newcastle disease virus, E. coli-endotoxin, or endogenous pyrogen.


Properties of tantalum powder used in tantalum bronchography.


Prostatic and hepatic metabolism of (1,2-3H) testosterone as affected by DDT pretreatment in the mouse.


Prostatectomy and deep vein thrombosis in Sudanese patients.


Prosthesis for the problem incus in stapedectomy.


Protein binding of bilirubin: comparison of in vitro and in vivo measurements of bilirubin displacement by drugs.


Protection of jeopardized ischemic myocardium by reduction of ventricular afterload.


Protein chain initiation in wheat embryo.


Protein output by the in vitro rabbit pancreas.


Protein polymorphisms in the hard clams Mercenaria mercenaria and Mercenaria campechiensis.


Protein synthesis with rabbit reticulocyte preparations.


Proteolysis of human factor II by factor Xa in the presence of hirudin.


Prothoracic glands in the regulation of ecdysone titres and metabolic fate of injected labelled ecdysone in Locusta migratoria.


Protochordate immunity. I. Primary immune response of the tunicate Ciona intestinalis to vertebrate erythrocytes.


Proton transfer mass spectrometry of peptides. A rapid heating technique for underivatized peptides containing arginine.


Proton-magnetic-resonance studies of complexes of pancreatic ribonuclease A with pyrimidine and purine nucleotides.


Provenance of the acetyl group of acetylcholine and compartmentation of acetyl-CoA and Krebs cycle intermediates in the brain in vivo.


Proximal gastric vagotomy with and without pyloroplasty--the present position.


Pseudodiploid karyotype in a breast carcinoma.


Proximal tubular lactate transport in rat kidney: a micropuncture study.


Pseudosarcomatous changes in antrochoanal polyps.


Psychiatrists' attitudes toward female homosexuality.


Psychiatric education in a family practice residency.


Psychiatric training: the wages of change.


Psychiatric disability determination under Social Security in the United States.


Psychiatrists: background, career and career alternatives of a group of recently appointed consultants.


Psychiatric services in a youth corrections unit.


Psilocybin: a pharmacological profile.

Psilocybin: a pharmacological profile.


Psychiatry and preventive detention.

Psychiatry and preventive detention.


Psychological aspects of sexual inadequacy in women.


Psychodermatology.

Psychodermatology.


Psychological and somatic disturbances following combined treatment of cervical carcinoma.


Psychological follow-up of families with childhood leukemia.


Psychological aspects: delay in the treatment of breast cancer.


Psychological changes associated with conditioning functional enuresis.


Psychosocial study of stammering in Egyptian children.


Psychosocial influences in diabetes mellitus.


Psychosomatic mechanism under social changes in Japan.


Psychotherapy in general practice.

Psychotherapy in general practice.


Pulmonary edema caused by methadone.

Pulmonary edema caused by methadone.


Pulmonary alveolar macrophage. Defender against bacterial infection of the lung. The rate of ingestion of inhaled bacteria by pulmonary alveolar macrophages is an important determinant of host defense. This parameter was investigated by infecting rats with finely dispersed aerosols bearing Staphylococcus aureus in high concentrations (about 10(s) bacteria/ft(3)/min). These aerosols deposited more than 10(6) bacteria/murine lung. At 0, 2(1/2), and 5 h after infection, bacterial clearance rates were measured in the left lung, and the intracellular or extracellular location of 100 bacteria was determined histologically in the right lung (perfused in situ). The clearance rates at 2(1/2) and 5 h were 44.5% and 76.9%, respectively. The percentages of intracellular bacteria were: 0 h, 54.8%; 2(1/2) h, 87.1%: 5 h, 91.9%. When rats were exposed for 4 h to 2.5 ppm of ozone (O(3)), bacterial clearance did not occur - 15.3%, although 78.7% of the bacteria were intracellular. Clumps of more than 10 bacteria-usually intracellular-were also present. These experiments demonstrate that phagocytic ingestion is an exceedingly rapid process, that in this experimental model the inactivation of inhaled staphylococci results almost entirely from phagocytosis, and that ozone-induced reductions in bacterial clearance are due to severe impairment of intrapulmonary killing mechanisms and minor impairment of bacterial ingestion.


Pulmonary actinomycosis.

Pulmonary actinomycosis.


Psychocultural aspects of contraceptive behavior in Jamaica. Individual fertility control in a developing country. Variables which influence the decision among primarily lower-class J amaican women to use or not to use contraception are discussed.  The material is based on interviews with 20 women, 14 of whom are clients at a family planning clinic.  Additional data is derived from shorter interviews with 80 family planning clients.  Case histories highlight the material.  The following psychocultural variables were considered significant.  1) Poor communication between sexual partners.  2) Strictness in child rearing, shielding the child from any knowledge of sexual relations and its possible outcome in the hope of keeping her chaste but in fact often leading to early sexual relations.  3) High value attached to the status and role of mother.  To many women, their mother is more important than their mate.  4) Negative perceptions of Ja maican men and of potential roles for women other than motherhood.  5) Socially permissible loose conjugal and household arrangements with little pressure on the men to assume responsibility for their children and much pressure on the woman to bear a child for each new mate.  6) Anxiety about contraception through ignorance and lack of communication with an informed, authoritative person.  The force of these factors is apparent in the fact that fertility patterns have changed little in the 7 years since the government mounted a massive family planning campaign.  However, the coming to a family planning clinic, especially early in a woman's reproductive period, represented a move in the direction of autonomy and self-determination for women.


Pulmonary edema in acute carbon monoxide poisoning.


Pulmonary endometriosis: report of a case.


Purification and properties of low molecular weight DNA polymerase from mammalian cells.


Purification and assays for the presence and biological functions of two eukaryotic initiation factors from rabbit reticulocytes that are required for initiation complex formation with rabbit reticulocyte ribosomes.


Purification and preliminary characterization of extracellular tubular structures from a culture of a 'fructose' mutant of Streptomyces roseoflavus var. roseofungini.


Purification and composition of a toxin from the posterior salivary gland of Octopus dofleini.


Pulmonary platelet aggregates associated with sudden death in man. Six human cases of unexpected sudden death were found to have many platelet aggregates in the small arterial vessels of the lungs. Postmortem examination revealed no other significant findings.


Purification and properties of choline acetyltransferase from the nervous system of different invertebrates.


Purification of an immunosuppressive principle derived from Ehrlich carcinoma cells.


Purification and subunit analysis of wheat-germ ribonucleic acid polymerase II. A procedure is described for the purification of the alpha-amanitin-sensitive DNA-dependent RNA polymerase [EC 2.7.7.6] from wheat germ. Solubilization of the enzyme activity was achieved by sonication of a crude extract in a high-salt buffer. Purification involved precipitation with protamine sulphate and (NH(4))(2)SO(4), chromatography on DEAE-cellulose and phosphocellulose, and sucrose gradient centrifugation. Under denaturing conditions the enzyme dissociated into five polypeptides with molecular weights and molar ratios of 220000 (0.9), 170000 (0.1), 140000 (1.0), 45000 (0.2), and 40000 (0.4). Approx. 1mg of purified RNA polymerase was obtained as a routine from 100g of starting material.


Pulmonary mechanics in infants. Methodological aspects.


Pulmonary edema in acute transection of the cervical spinal cord.


Pulmonary mechanics during the first year of life.


Purification and properties of the cholinergic receptor protein from Electrophorus electricus electric tissue.


Purification of beta-glucosidase activities from bovine spleen by affinity chromatography.


Purification of animal neurotoxins: isolation and characterization of three neurotoxins from the venom of Naja nigricollis mossambica peters.


Purification of calf liver tRNA's.

Purification of calf liver tRNA's.


Purification of cytochrome b-561. An integral heme protein of the adrenal chromaffin granule membrane.


Purification of eukaryotic initiation factor 1 (EIF1) from Artemia salina embryos.


Purification of male guinea pig kidney 17 beta-hydroxy-C19-steroid dehydrogenase.


Purification of DNA-dependent RNA polymerases A and B from ovaries of Xenopus laevis.


Puromycin: a questionable drug for studying the mechanism of thyroid calorigenesis in vivo. Puromycin fails to alter minimal oxygen consumption of rats treated with thyroxine, provided the rectal temperatures of these rats are maintained at 37.8 degrees to 38.1 degrees C. The previously reported puromycin-induced decline in basal metabolic rate of thyroxine-treated rats may have been due to the hypothermia produced by this drug.


Pyrazole as an antidote for ethylene glycol poisoning.


Pyridoxal 5'-phosphate in plasma: source, protein-binding, and cellular transport.


Pyruvate kinase isozyme changes in parenchymal cells of regenerating rat liver.


PHA-stimulation in whole blood microcultures: an improved technique.


Pyrogenic specificity of streptococcal exotoxins, staphylococcal enterotoxin, and gram-negative endotoxin. Streptococcal exotoxin and staphylococcal enterotoxin share several biological properties, including pyrogenicity, lymphocyte mitogenicity, and enhancement of gram-negative endotoxin lethality. These analogies of the toxins prompted comparative pyrogenic studies. When American Dutch rabbits were immunized by repeated intravenous injections of small amounts of staphylococcal enterotoxin, they exhibited a decreased febrile response upon challenge when compared with control animals not previously injected. The same animals responded similarly to control groups when challenged with streptococcal exotoxin A, B, or C. No cross-reactivity was observed in reciprocal cross-tests, using animals immune to the streptococcal toxins and challenging with staphylococcal enterotoxin. No cross-reactivity between either the streptococcal or staphylococcal toxins and bacterial endotoxin was observed.


Qualitative and quantitative study of the flavonoid content of the different organs of Sophora japonica at different stages of development.


Quality assurance of pharmaceutical services in hospitals.


Quantification of psychosocial variables in intrinsic asthma relationship to physiologic variability.


Quantitative dehydrogenase histochemistry of glial cells in tissue culture. I. Quantitation of the reaction products with special reference to the reduction intermediate of nitro-blue tetrazolium.


Quantitative analysis of motility recordings in the human small intestine.


Quantitative determination of acrosin activity in human spermatozoa.


Quantitative determination of carisoprodol, phenacetin, and caffeine in tablets by near-IR spectrometry and their identification by TLC.


Quantitative determination of the enantiomeric purity of synthetic pyrethroids. II. S-Bioallethrin.


Quantitative determination of clonazepam and its metabolites in human plasma by gas chromatography.


Quantitative ultrastructural studies on inhibited and on partly stimulated gastric parietal cells.