Parathyroid hormone assay in primary hyperparathyroidism: experiences with a radioimmunoassay based on commercially available reagents.


Shortened radioimmunoassay for human growth hormone.


Kinetic determination of total serum protein with a centrifugal analyzer.


Newspapers and magazines as potential sources of dietary lead for dogs.


Newcastle disease virus: virus particle and RNA synthesis in different host cells and at different temperatures.


Induction of virus ribonucleic acids in non-permissive MSV-IF+ cells infected with NDV.


The significance of influenza virus neuraminidase in immunity.


Keeping immunizations up to date.

Keeping immunizations up to date.


The single umbilical artery.

The single umbilical artery.


The safety of using sonar.

The safety of using sonar.


Effect of calcitonin on meal-stimulated gastric acid secretion and serum gastrin concentration.


Radioimmunoassay for gastric inhibitory polypeptide.


A model for LH levels in the recently-castrated adult rat and its comparison with experiment.


A model for antibody diversity based on non-conservative DNA synthesis errors.


Neonatal urinary ascites: a report of 2 cases of unusual etiology and a review of the literature.


The RAS test: a new test of reflex activity of the external urethral sphincter in neurogenic bladder.


Gonadotropin levels in sera and pituitary glands of female rats treated with alloxan.


Stimulation of RNA synthesis in isolated mouse brain nuclei by a brain cytosol factor.


Effects of synthetic salmon calcitonin in patients with Paget's disease of bone.


Editorial: CONNECTICUT MEDICINE. Professional services regulation organization.


Urinary diversion by circle tube: a valuable adjunct to the management of pelvic carcinoma.


Ovarian progestin secretion in lactating rats: effect of intrabursal injection of prolactin antiserum, prolactin and LH.


Preparation and properties of microsomal membranes from isozonal cells of beef adrenal cortex.


Absence of a critical period in estrogen-induced release of LH in the anestrous ewe.


The effects of xylose on the isolated lens.


Subacute sclerosing panencephalitis. Correlation of clinical, neurophysiologic and neuropathologic findings.


Familial megalencephaly or hydrocephalus?


Progressive supranuclear palsy with action myoclonus, seizures.


Plasma levels of methsuximide and N-desmethylmethsuximide during methsuximide therapy.


Early diagnosis of ulnar nerve palsy. An electrophysiologic study.


Parkinsonism-dementia of Guam: treatment with levodopa and L-alpha-methyldopahydrazine.


Persistent motor neuron discharges of central origin present in the resting state. A case report of alcohol-induced muscle spasms.


Electron microscopic evidence for innervation of intracerebral arterioles in the cat.


Tongue flap for reconstruction of the lips after electrical burns.


PSRO-update 1974.

PSRO-update 1974.


Obstetrics and gynecology in the new society.


Studies with two genera of Tuberculariaceae: Epicoccum and Fusarium.


PSRO criteria for hospital care of patients with asthma.


Dictyostelium discoideum: a new method for cloning in liquid medium. Dictyostelium discoideum can be cloned in droplets of liquid medium by a method that permits observation of the complete life cycle. This alternative to solidified media provides advantages in clonal analysis.


Determination of soluble immune complex molar composition and antibody association constants by ammonium sulfate precipitation.


Failure of terminal complement components to induce lysis of Moloney virus transformed lymphocytes.


Abruptio placenta: fetal sequelae.

Abruptio placenta: fetal sequelae.


Adsorption properties in vitro and in vivo of antibodies raised against rat brain blood vessels.


Improving the quality of medical care--a very mixed bag.


Micropuncture study of tubule sodium reabsorption in dilutional hyponatremia.


Aggression management and sex and racial differences in mortality.


Aggression, social pressure and asymptote in laboratory mouse populations.


Estrous cycle and temporal pattern of feeding in female rats.


Tuberculosis in the Transkei. An epidemiological survey.


The use of respiratory stimulants in respiratory failure.


The effects of ligation of cauda epididymidis on the dog testis.


"Assisted" covert sensitization in the treatment of exhibitionism.


Induction of interferon by nonreplicating single-stranded RNA virus.


The effect of cell density on the production of interferon.


Study of the growth regulation of preimplantation mouse embryos using concanavalin A.


Serum LH, FSH and prolactin levels during the estrous cycle in the hamster.


Antiviral activity of 9-beta-D-arabinofuranosyladenine (ara-A) against Gross murine leukemia virus in vitro.


Body fat and fatty acid synthesis in five lines of mice selected for growth rate.


Placental lesions in congenital giant pigmented nevi.


Syndrome of persistent pulmonary vascular obstruction of the newborn: proentgen findings.


Ion exchange technique for the determination of chlorinated phenols and phenoxy acids in organic tissue, soil, and water.


Surgical audit using predetermined weighted criteria.


Vitro alterations of the product distribution of the fatty synthetase from Mycobacterium phlei.


Subunit structure of soybean agglutinin.


The telephone connection: hospitals offer mental health care in a youthful package.


Large scale isolation and characterization of calf thymocyte plasma membranes.


The way to the community's health is through its diet.


Cytologic screening by a nurse on an in-hospital population.


The XYY syndrome: a study of four subjects and their families.


Stereoselectivity of presynaptic alpha-adrenoceptors involved in feedback control of sympathetic neurotransmitter secretion.


American Medical Association policy of Professional Standards Review Organizations as amended and adopted by the House of Delegates, December, 1973.


The constancy of RNA-polymerase activities during a transcriptionally dependent cell differentiation in Naegleria.


Fate of egg white trypsin inhibitor and start of proteolysis in developing chick embryo and newly hatched chick.


Polar lobe formation and cytokinesis in fertilized eggs of Ilyanassa obsoleta. I. Ultrastructure and effects of cytochalasin B and colchicine.


Enzyme patterns in two species of Xenopus and their hybrids.


Intracellular and extracellular enzyme patterns during microcyst germination in the cellular slime mold Polysphondylium pallidum.


Fundamental stimulus for erythropoietin production in the neonatal rat.


Adrenal relationships to aggressiveness in isolated female mice.


An increased secretion of oestradiol following unilateral ovariectomy of cyclic hamsters.


A biological aging test for the central regulation of the estrous cycle in the rat. Its first application.


The injection of turkey hatching eggs with tylosin to eliminate Mycoplasma meleagridis infection.


Dactylariosis--a newly recognized fungus disease of chickens.


Authorizations and restrictions on soy protein in foods in the U.S.


Nutritional value and economic aspects of fortification of foods of plant origin with soy protein.


Nutritional effectiveness of soy cereal foods in undernourished infants.


Chemical-nutritional physiological evaluation of a few products manufactured with the use of soy protein.


Soy protein isolates in hypoallergenic infant formulations and humanized milks.


Use of soy protein isolate in slimming food.


Study of nutritive and biological value of textured soy proteins in adults, children, and rats.


Nutritional experience with infant formulas containing soy.


Nutritional aspects in textured soy proteins.


Editorial: Horse doctor vs equine practitioner.


Why do dogs bite?

Why do dogs bite?


Nucleotide clusters in deoxyribonucleic acids. Pyrimidine oligonucleotides of mouse L-cell satellite deoxyribonucleic acid and main-band deoxyribonucleic acid.


Studies on the structure of deoxyribonucleoproteins. Spectroscopic characterization of the ethidium bromide binding sites.


Circular dichroism and thermal denaturation studies of nucleohistone IIb2.


A special form of deoxyribonucleic acid dependent ribonucleic acid polymerase from oocytes of Xenopus laevis. Isolation and characterization.


Denaturation of human and Glycera dibranchiata hemoglobins by the urea and amide classes of denaturants.


Catalysis by chymotrypsinogen. Demonstration of an acyl-zymogen intermediate.


Further analysis of sensory inattention following lateral hypothalamic damage in rats.


Metabolic and endocrine aspects of the ventromedial hypothalamic syndrome in the rat.


Infection of the jird, Meriones unguiculatus, with the filarial worm, Dipetalonema viteae: central nervous system invasion and pathology.


On certain practical inadequacies of distinctive feature systems.


Treatment of the depressed outpatient.

Treatment of the depressed outpatient.


Intracytoplasmic junctions in cardiac muscle cells. JUNCTIONAL STRUCTURES FORMED BY TWO PARTS OF THE PLASMA MEMBRANE OF THE SAME CARDIAC MUSCLE CELL WERE OBSERVED IN VENTRICULAR MYOCARDIUM OF: a) patients with neoplasms, aortic valvular disease or idiopathic hypertrophic subaortic stenosis and b) dogs subjected to prolonged normothermic anoxic cardiac arrest. Most of these structures had features of desmosomes; other, more complex structures had components with features of desmosomes, fasciae adherentes and nexuses, and, therefore, resembled intercalated discs. These intracytoplasmic junctions were localized to: a) the peripheral cytoplasm at the sides or ends of cells, b) narrow invaginations of plasma membranes, c) narrow zones of deep, broad plasmalemmal invaginations and d) narrow branches of T tubules. In patients with idiopathic hypertrophic subaortic stenosis or aortic valvular disease and in the dogs subjected to anoxic cardiac arrest, intracytoplasmic junctions were observed in hypertrophied or degenerated muscle cells which were located in areas of fibrosis and which showed loss of contact with adjacent cells. In patients with neoplasms, intracyto-plasmic junctions were found in degenerated cells which were located in areas of interstitial edema and which also showed loss of contact with adjacent cells. Our observations suggest that remodeling of cell surfaces following loss of intercellular contact is the most likely mechanism of formation of intracytoplasmic junctions.


Animal model: feline GM1 gangliosidosis.


Legal and ethical aspects of behavior control.


Dimensions of the therapeutic milieu: a study of mental hospital atmosphere.


The effect of a community mental health center upon state hospital utilization.


Letter: Delusions as political crimes.

Letter: Delusions as political crimes.


Letter: On the future of psychoanalysis.


Ultrastructural studies in human orf.

Ultrastructural studies in human orf.


Selective cell survival and changes of marker properties during cryopreservation for up to 16 years.


Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.


A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.


Antagonism between DNA synthesis inhibitors and protein synthesis inhibitors in mammalian cell cultures.


Lactate and pyruvate metabolism and reducing equivalent transfer in Ehrlich ascites tumor.


Factors affecting the noncovalent binding of chlorambucil to rabbit immunoglobulin G.


Heterakis gallinarum in the guniea fowl, Numida meleagris: survival and comparative potential for transmitting Histomonas meleagridis.


Necator americanus: activity patterns in the egg and the mechanism of hatching.


Crossed immunoelectrophoresis and electroimmunoassay of IgM.


Stimulators and inhibitors of hepatic porphyrin formation in human sera. Human sera were found to contain factors that stimulate and factors that inhibit porphyrin formation by cultured avian liver cells. The capacity of sera to stimulate or inhibit porphyrin formation varied in different hormonal states and in the porphyrias. Sera from 31 post partum women, eight of whom were not lactating, inhibited porphyrin formation to a mean level 30% below the level in control cultures and also inhibited drug and steroid stimulation of porphyrin formation. In contrast, mean porphyrin formation compared to control cultures was increased between 9 and 21% by sera from 52 normal subjects, 16 women on oral contraceptives, and 11 pregnant women. It was increased 193% by sera from nine subjects with acute intermittent porphyria and 172% by sera from 13 subjects with porphyria cutanea tarda. Heated sera or ethanol extracts of sera from all groups of subjects further increased the mean porphyrin stimulation by sera and, for the post partum subjects, eliminated the inhibitory effect. Ethanol extracts of sera from 28 oral contraceptive-treated women caused significantly greater mean stimulation of porphyrin formation than did extracts of sera from 30 normal women. While sera from 17 out of 22 porphyric subjects contained both stimulatory and inhibitory factors, 5 out of 22 had no evidence of an inhibitory component. There appeared to be heterogeneity in the occurrence of the factors among porphyrics.The factor(s) in sera responsible for porphyrin stimulation were heat-stable and insensitive to trypsin; were present in the supernates after ethanol precipitation of plasma proteins; were extractable in ethyl acetate and nondialyzable; and they migrated with the albumincontaining fraction of serum during electrophoresis. The factor(s) responsible for porphyrin inhibition were heat labile, sensitive to trypsin, and resistant to neuraminidase; were present in the ethanol precipitates of sera and were nondialyzable; and they migrated with the gamma globulin fraction of serum during electrophoresis. Inhibition of porphyrin formation was not attributable to heme, free or bound as hemoglobin, hemopexin, or hemalbumin.


Blastogenesis of autologous, allogeneic, and syngeneic (identical twins) lymphocytes in response to lymphokines generated in dinitrochlorobenzene-sensitive human leukocyte cultures.


Structural studies on a human IgA1 myeloma protein with a carboxy-terminal deletion.


Development of reaginic antibody-forming cells in the spleen and bone marrow of immunized mice.


Production of alpha 1 and alpha 2 immunoglobulin heavy chains during fetal life.


Effect of ECT on dopaminergic and noradrenergic mechanisms. I. Effect on the behavioural changes induced by reserpine, alpha-methyl-p-tyrosine or amphetamine.


Types of tooth cusp occurrence asymmetry in human monozygotic and dizygotic twins.


Genetic influences on dentition and dental arch dimensions: a study of monozygotic and dizygotic triplets.


Effect of suicide prevention centers, on suicide rates in the United States.


Shock-induced aggression: opposite effects of intraventricularly infused dopamine and norepinephrine.


Comparison of the effects of anisomycin on memory across six strains of mice.


Effects of central and peripheral adrenergic and cholinergic modification on time-dependent processes in avoidance performance.


Editorial: On peering peers.

Editorial: On peering peers.


Electroshock amnesia to aversive heart-rate conditioning in rats.


Letter: Nutmeg for diarrhea.

Letter: Nutmeg for diarrhea.


Follicle-stimulating hormone secretion in the female rat: cyclic release is dependent on circulating androgen. In adult cyclic female rats, intravenous injections of an antiserum to testosterone prevented the continued increase in serum follicle-stimulating hormone (FSH) which normally occurs during the early morning hours of estrus. This treatment did not prevent the initial increases in serum FSH (and luteinizing hormone) which occur during the critical period (1400 to 2000 of proestrus), nor did it interfere with subsequent ovulation. These observations indicate the existence of two separate mechanisms for preovulatory FSH release in the rat and implicate circulating testosterone as the stimulus for continued secretion of FSH during estrus.


Recovery from retrograde amnesia: a learning process. Retrograde amnesia was produced in rats by electroconvulsive shock. Memory recovered if the animals were given repeated test trials. Memory did not recover if steps were taken to reduce the conditioning properties of the test trials; the manipulations included eliminating the response, altering the apparatus cues, or extinguishing conditioned "fear" by confining animals to the apparatus during the first test trial.


Elongation of oestrous cycle in the guinea-pig following active immunisation against prostaglandin F-2 alpha.


Lack of effect of schizophrenic sera on growth of human HeLa cells.


Preoptic unit activity and gonadotropin release.


Concurrent general acid-electrostatic catalysis in vinyl ether hydrolysis and aspartic-52 of lysozyme.


Analysis of egg lipids. A student project.


Editorial: Twelve steps toward repeal.

Editorial: Twelve steps toward repeal.


Absence of shock-elicited aggression in pigeons. Two pigeons that attacked a taxidermically prepared target pigeon during a schedule of positive reinforcement for key pecking, and two that did not, were shocked through implanted electrodes in the presence of the target. Shock intensities of 2 and 4 mA, durations of 0.1 and 1.3 sec, and frequencies of 2, 6, 20, and 35 per minute were delivered across 16 sessions with 180 shocks per session. No pigeon attacked the target; one pecked the shockplug on its back. The two pigeons that had not attacked during the positive reinforcement schedules were conditioned to peck the target for food reinforcement before another 16 sessions of shock. No attack was observed in these shock sessions. During subsequent positive reinforcement of key pecking, the target was attacked by the two pigeons that had originally attacked and by one that had not. Absence of shock-elicited attack in these pigeons may be related to the parameters of the experiment or may be yet another instance of the absence of shock-elicited attack in the class Aves. At least under the present conditions, it was not possible to predict the level of attack during electric shock from the level of attack during schedules of positive reinforcement for key pecking.


Intussusception in medium sized arteries.


Nippostrongylus brasiliensis: observations on factors affecting the establishment of secondary worm populations in rats.


Incidence versus degrees of rotation on the Minnesota Percepto-Diagnostic Test in brain-damaged and schizophrenic patients.


Accidental intracarotid artery injection of promazine in the horse.


The operative treatment of spinal angiomas.


Proper use of animals in schools: an educational program.


Annual administrative reviews. 3. Patient care.


Annual administrative reviews. Manpower and social controls.


Annual administrative reviews. Mental health.


Annual administrative reviews. Patients' rights.


Annual administrative reviews. Patient care evaluation.


Annual administrative reviews. Community relations.


Annual administrative reviews. Governance.


Annual administrative reviews. Delivery systems.


Annual administrative reviews. Safety and security.


Species variation in the location of upper urinary tract pacemaker cells.


Kentucky Medical Association position paper on Professional Standards Review Organizations.


Editorial: Can the physicians do it?

Editorial: Can the physicians do it?


Endemic hydatid disease in Utah. A review.


Dopamine nerve terminals in the rat limbic cortex: aspects of the dopamine hypothesis of schizophrenia. The existence of cortical dopamine nerve terminals is demonstrated with a highly sensitive modification of the Falck-Hillarp fluorescence technique. This confirms previous biochemical reports of high dopamine levels in the cortex. The histochemistry reveals that the distribution is regional and confined to the limbic cortex.


Editorial: Advantages gained through a quality assurance program.


Quality assurance in the provision of hospital care. Education is PSRO goal.


QAP: the AHA's program.

QAP: the AHA's program.


Quality assurance in the provision of hospital care. Case study. Teamwork forges medical care evaluation system.


Quality assurance in the provision of hospital care. Case study. Audit network aids continuing medical education.


Genetic control of recombination in Schizophyllum commune: evidence for a new type of regulatory site.


Corresponding-site interference, synaptinemal complex structure, and 8+:0m and 7+:1m octads from wild-type x mutant crosses of Ascobolus immersus.


An incompatibility system determined by three factors in a species of Psathyrella (Basidiomycetes).


Triterpenes of the root-bark of Salacia prenoides DC.


Biosynthesis of porphyrins and related macrocycles. IV. Synthesis of isomeric aminomethylpyrromethanes for biosynthetic study.


Studies related to penicillins. XII. Reactions of (1R,5S)-3-benzyl-7-(2-methylprop-1-enyl)-2-oxa-4,7-diazabicyclo(3.2.0)hept-3-3n-6-one with alcohols and with acids.


Two-environment selection with inbreeding in Schizophyllum commune.


Constitution and absolute configuration of austdiol, the main toxic metabolite from Aspergillus ustus.


Branched-chain sugars. II. Characterization of methyl 2,4-di-O-acetyl-3,6,-dideoxy-3-C-methyl-3-nitro-alpha-L-glucopyranoside and some of its chemical transformations.


Effects of gene dosage and hormones on the expression of Dr in the platyfish, Xiphophorus maculatus (Poeciliidae).


Bare-patches, a new sex-linked gene in the mouse, associated with a high production of XO females. I. A preliminary report of breeding experiments.


The maintenance of the genetic variability of polygenic characters by heterozygous advantage.


Steroids. 18. Spontaneous decomposition of 5alpha-bromo-6beta-hydroxy-steroids.


Our junk yard: a study of the social background and habits of drug users in a small Hoosier community.


Cyclical changes in the vaginal epithelim of the rat seen by scanning electron microscopy.


A cephalometric investigation of the sagittal growth of the second-trimester fetal face.


Growth and distribution of human fetal brown fat.


Propranolol therapy throughout pregnancy: a case report.


Anaphylactic reactions to chymopapain during general anesthesia: a case report.


One solution to the problem of the prone position for surgical procedures.


Thoughts about medical writing. XXII. Pruning your hedges.


Will you anesthetize a sheep?

Will you anesthetize a sheep?


Unilateral nephrotoxicity associated with methoxyflurane anesthesia: a case report.


Evaluation of a tapered spinal needle.

Evaluation of a tapered spinal needle.


The pseudo junkie: evolution of the heroin lifestyle in the non-addicted individual.


Patient wins verdict for paralysis following surgery.


Clinical studies involving neostigmine reversal of d-tubocurarine, gallamine, and pancuronium in man.


Editorial: Peer review and all that. Three little words.


Shell selection and aggressive behavior in two sympatric species of hermit crabs.


Side effects of ketamine in pediatric anesthesia.


Synthesis of RNA with relation to aging in Rhizoctonia solani.


Abdominal and thoracic surgery in adults with ketamine, nitrous oxide, and d-tubocurarine.


Inhibitory effect of serotonin on ovulation in adult rats.


Changes in plasma luteinizing hormone and prolactin after injection of vinblastine into the median eminence of the rat.


Alterations in the incorporation of (3H)lysine into proteins of the medial pre-optic area and specific hypothalamic nuclei after ovariectomy in the adult female rat.


Correspondence: Operating room flash fire.


An exponential model relating censored survival data and concomitant information for prostatic cancer patients.


Experiences with the use of ketamine for parturition. I. Primary anesthetic for vaginal delivery.


Pregnancy dependence of mammary tumors in strain DDD mice.


Inability of serum to completely reverse density-dependent inhibition of cell growth in culture.


Interferon and cell division. IX. Interferon-resistant L1210 cells: characteristics and origin.


Letter: Brevital for the extraction of four teeth.


Letter: Intrapartum sedation of fetus.

Letter: Intrapartum sedation of fetus.


Growth of transplanted and induced tumors in rats under a schedule of punished behavior.


Concanavalin A agglutinability of normal hamster cells grown in 2-deoxy-D-glucose.


A significant increase in developmental malformations of the renal tract in perinatal autopsies at Royal Women's Hospital, Brisbane, 1972-1973.


Neonatal bonadal hormones: effect on maternal and sexual behavior in the male rat.


The effect of ECS upon spontaneous alternation in rats.


Facilitated avoidance learning and stress-induced corticosterone levels as a function of age in rats.


Maternal and sex-related influences on locomotor activity in rats following weaning.


Iatrogenic arteriovenous fistulas.

Iatrogenic arteriovenous fistulas.


Intestinal obstruction in the neonate due to vitelline duct cysts.


Proceedings: Two primitive urethral operations in Oceania: subincision in Australia and thoka-losi in Fiji and the Tonga islands.


Electromyography of the detrusor, a method of investigation of normal and abnormal detrusor function.


Antibodies reacting with lipopolysaccharides from Bacteroides melaninogenicus, in serum from normal human subjects.


New technique for obtaining nematode ova from sheep faeces.


Baltimore's new geriatric nutrition program.


Data concerning the factorial genetics of rye (Secale cereale L.). II. Characteristics of stem branching and the abscence of ear.


Genetic classification of sources of cytoplasmic male sterility in maize.


Dose effect of brachypodism-H gene in mice.


Effects of dietary energy concentration on utilisation of energy by broiler chickens and on body composition determined by carcass analysis and predicted using tritium.


Red cell enzymes in cord blood and plasma bilirubin levels in the first week of life.


Protein-detergent interactions. Properties and thermodynamic analysis of the system ferrimyoglobin-laurylpyridinium chloride.


The allosteric activation of mammalian alpha-amylase by chloride.


Report on eggs and egg products.

Report on eggs and egg products.


Editorial: PSRO: tyranny in the making.

Editorial: PSRO: tyranny in the making.


Changes of the conformation of rabbit IgG antibody caused by the specific binding of a hapten. X-ray small-angle studies.


Report on analytical mycology of foods and drugs.


Oxidation of N-naphthylhydroxylamines to nitrosonaphthols by air.


Synthesis of (1-(D-2-hydroxy-3-mercaptopropanoic acid))oxytocin, a diastereoisomer of the hydroxy-isostere of oxytocin.


Electrochemical reduction of cephalosporanic acids.


Diarylpropanoids from nutmeg and mace (Myristica fragrans Houtt.).


Some dihydro-cytidines and -isocytidines.


An improved synthesis for 2beta-hydroxytestosterone.


Unsquared genetic correlations.

Unsquared genetic correlations.


A radioimmunoassay for plasma insulin using zirconyl phosphate gel.


Proceedings: Effect of cone biopsy of the uterine cervix on subsequent reproduction and outcome of pregnancy.


Mutiple-cause analysis of deaths of patients treated with radio-iodine.


Stimulation of DNA synthesis by prolactin in rabbit mammary tissue.


Cycloheximide-resistant glycosylation in L cells infected with Chlamydia psittaci. L cells (mouse fibroblasts), uninfected and infected with the meningopneumonitis strain of Chlamydia psittaci, were labeled with [(14)C]glucosamine, and their membranous organelles were separated by isopycnic equilibrium centrifugation of whole cell homogenates on discontinuous sucrose gradients. Glycosylation of host membranes continued throughout the infection. Cycloheximide almost completely inhibited glycosylation in uninfected L cells, but it only partially inhibited the process in infected host cells. Cycloheximide-resistant glycosylation of membrane fractions with [(14)C]glucosamine increased as the infection proceeded and was probably due to the action of chlamydial enzymes. Modification of host membranes by glycosylation may play a role in the natural development of chlamydial infections.


Surface modification and electrophoresis of normal and transformed BHK21 cells.


Structural and functional modifications of the nucleus during oogenesis in the mosquito Aedes aegypti.


Cell wall formation by soybean callus protoplasts.


Nuclear sheets in the egg of a fern, Dryopteris filix-mas.


Synthesis of messenger and ribosomal RNA precursors in isolated nuclei of the cellular slime mold Dictyostelium discoideum.


Air-, water- and vacuum-thawing of frozen pork legs.


Current status of PSRO.

Current status of PSRO.


Guiding employees to community resources.


Counseling techniques for mental health.


Blood pressure and weight control programs.


The nurse and employee health--efficiency and stability: the new bond--surveillance.


Special programs on health and safety.

Special programs on health and safety.


The role of the nurse in an OSHA inspection.


The nurse and employee health--efficiency and stability: introduction.


The nurse and employee health--efficiency and stability. Orientation of a new employee.


The nurse and employee health--efficiency and stability: job placement.


N,N'-carbonyldiimidazole as coupling reagent for the preparation of bovine serum albumin conjugates.


Toward a mechanism of the anti-aggression effects of chlordiazepoxide in rats.


Effect of apomorphine and nigrostriatal lesions on aggression and striatal dopamine turnover during morphine withdrawal: evidence for dopaminergic supersensitivity in protracted abstinence.


The fertility of stallions.

The fertility of stallions.


Carcinoid tumors. A study of 204 cases.

Carcinoid tumors. A study of 204 cases.


Proceedings: The early lymphatic spread of manifest prostatic adenocarcinoma.


Specific laboratory test for diagnosis of multiple sclerosis. Lymphocytes from patients with multiple sclerosis are much more susceptible to the inhibitory activity of linoleic acid (0.08 mg/ml) when tested for sensitization to thyroid by the macrophage electrophoretic mobility test (91% inhibition) than are those from normal subjects (57% inhibition). Cells from patients with a variety of other neurological diseases give 47% inhibition with linoleic acid. These differences are specific for multiple sclerosis and can be used as an in-vitro diagnostic test for the disease. Nearly 43% of clinically normal near relatives of patients with multiple sclerosis show an "anomalous" figure of about 77%; in the remainder the figure is the same as in the general population (57%). An anomalous result is compatible with lifelong freedom from M.S. Possibly a congenital anomalous handling of unsaturated fatty acids is a constant feature of the disease.


Psychiatry in the Soviet Union.

Psychiatry in the Soviet Union. The services for chronically handicapped people with psychiatric disorders in the Soviet Union are described. The system is based upon a network of community units, each of which includes a day centre, a follow-up clinic, and a sheltered workshop. British services could profitably learn from the experience of these units. The diagnostic system used by many Soviet psychiatrists is different from that incorporated in the International Classification of Diseases. In particular, the term "schizophrenia" is used to describe conditions which British psychiatrists would label in other ways.This clinical difference partly explains the different concept of "criminal responsibility," but another large component of the difference is political rather than medical. There are also variations from British practice in certain juridical procedures. These differences together make Soviet psychiatric practice in the case of political dissenters unacceptable to most British psychiatrists. It is too soon to say that frank discussions of these matters could not lead to improvement. British and Soviet psychiatrists still have something to learn from each other.


The interaction of lysine vasopressin with free and agarose-bound bovine neurophysin II. Two classes of binding sites.


Purification and properties of DNA polymerases from chick embryo.


Isolation and DNA-RNA hybridization properties of small-molecular-weight nuclear RNA components from baby-hamster-kidney cells.


Affinity chromatography on immobilised adenosine 5'-monophosphate. 2. Some parameters relating to the selection and concentration of the immobilised ligand.


Studies on cellular adhesion in tissue culture. XIV. Positively charged surface groups and the rate of cell adhesion.


Quantitative changes in chromosomal activity during chicken myogenesis in vitro. a DNA-RNA hybridisation study.


Changes in membrane potential during the cell cycle.


Morphological alterations and increase of S-100 protein in cultured human glioma cells deprived of serum.


Absence of DNA-associated RNA in the fully repressed nucleus of chicken erythrocyte.


Sister chromatid exchanges in isolabeling.


The influence of lipids on dynamic properties of rhodopsin.


Effect of feeding "carbohydrate-free" diets on the chick's requirement for vitamin B-12.


Effect of feeding "carbohydrate-free" diets on the chick's requirement for methionine.


Unilateral stimulation of bovine ovaries by local injection of pregnant mare's serum gonadotrophin.


Effect of the consumption of glycerides containing behenic acid on the lipid content of the heart of weanling rats.


Oxygen requirements for the maturation of hamster oocytes.


Evaluation of radioimmunoassay kits for the beta subunit of hCG, FSH, and hLH.


Clinical applications of the wing sound device.


Letter: An interesting urological case and some lessons.


The role of complement in the HL-A antibody-mediated lysis of lymphocytes.


Synthesis of poly(A) sequences in poxvirus-infected cells treated with interferon or poly(rI)-poly(rC).


Cryosurgical device with adjustable cold output.


Cellular binding characteristics of human interferon.


Phosphorus balances of adults consuming several food combinations.


Vitamins in frozen convenience dinners and pot pies.


Mechanism for increase in intracellular concentration of free calcium in fertilized sea urchin egg. A method for estimating intracellular concentration of free calcium. Intracellular free calcium concentration in the sea urchin egg was calculated to increase from 0.1 mM in an unfertilized egg to 1 mM in a fertilized egg 10 min after fertilization, based on measurement of the dissociation constant between free calcium and sea urchin egg homogenate. The dissociation constant between free calcium (dialyzable calcium) and homogenate of sea urchin eggs was measured by means of dialysis equilibrium. The dissociation constant of the unfertilized egg was about 10(-4) M and that of the fertilized egg was about 10-3 M in three species of sea urchin, Hemicentrotus pulcherrimus, Anthocidaris crassispina, and Pseudocentrotus depressus. An increase in the dissociation constant of the unfertilized egg homogenate was observed after the addition of calcium ion at a concentration above 0.3 mM, the dissociation constant becoming the same as that observed in the fertilized egg homogenate after the administration of CaCl(2) at a concentration above 1 mM. Sodium ion also caused a decrease in the calcium-binding ability of the unfertilized egg homogenate. Therefore, penetration of calcium ion or sodium ion upon fertilization might induce an increase in the dissociation constant and then intracellular concentration of free calcium would increase at fertilization. Almost all calcium-binding ability of the egg homogenate was found in the microsomal fraction, and the substance which bound calcium was thought to be protein in nature, since trypsin could decrease the level of calcium-binding substance in the homogenate of the eggs.


Gout in the temporomandibular joint. Report on a case.


Management of laryngo-tracheal stenosis in children.


Unusual osteomyelitis following superficial dog bite.


Quantitative parameters in nystagmography. I. The velocity of the slow phase.


Unsuccessful attempts to produce avascular necrosis of bone by compression-decompression stress and alcohol ingestion in guinea pigs.


Quantitative parameters in nystagmography. II. Nystagmus amplitude.


AVC in hearing channels.

AVC in hearing channels.


Tympanoplasty to the radicalized middle ear.


Otoplasty as a procedure for the outpatient clinic.


Electroglottographic examination on the excised larynx.


X-ray contact therapy in epiglottic carcinoma.


Carcinoma of the hypopharynx, a retrospective study of 150 cases.


Incisions for neck dissection and laryngectomy.


Fetus in fetu.

Fetus in fetu.


Differential assay for choline acetyltransferase.


The use of Polaroid Land film in radioautography.


Effects of potassium iodide on aspartate aminotransferase.


Dansyl chloride binding to proteins. Quantitative estimation of N-terminal, lysyl, and tyrosyl residues by the radioactive reagent.


The reactive sulfhydryl groups of cytoplasmic aspartate aminotransferase. Localization in the primary structure and spectral properties of their mixed disulfide derivatives with N-dansylcysteine.


Covalent structure of calf-thymus ALK-histone.


Serum inhibitors of cellular immunity in human neuroblastoma. IgG subclass of blocking activity.


Studies of glutamate dehydrogenase. Identification of an amino group involved in the substrate binding.


Pyrroles and related compounds. 25. Pemptoporphyrin, iso-pemptoporphyrin, and chlorocruoroporphyrin (Spirographis porphyrin).


Industrial application of microbial lipases: a review.


Pyrroles and related compounds. 26. Pyrrole beta-keto-esters.


Pyrroles and related compounds. 28. Beta-keto-esters in the porphyrin series.


Pyrroles and related compounds. 27. Syntheses of porphyrins with a nuclear carboxy-group.


Pyrroles and related compounds. 29. Vinylporphyrin beta-keto-esters.


Pyrroles and related compounds. 30. Cyclisation of porphyrin beta-keto-esters to phaeoporphyrins.


Pyrroles and related compounds. 31. Porphyrin ketones.


Angiosarcoma of liver in the manufacture of polyvinyl chloride.


Comparison of methods for the determination of available lysine value in animal protein concentrations.


New method of intrauterine evaluation by the combined use of fetoscopy and ultrasound.


Letter: Complications of pelvic operation following abdominoperineal resection.


Morphologically altered eggs of Trichuris trichiura following treatment with mebendazole.


In vivo effects of a new anthelmintic, mebendazole (R-17,635) on the eggs of Trichuris trichiura and hookworm.


Ingwavuma virus in Thailand. Infection of domestic pigs.


The rate of change of left ventricular volume in man. I. Validation and peak systolic ejection rate in health and disease.


Cell cycle dependent turnover of non-histone proteins in chromatin.


Spreading of fibroblast-like cells on grooved surfaces: a study by scanning electron microscopy.


Inhibition of BHK cell adhesion to plastic tissue culture surfaces coated with serum-bound trypsin.


A temperature-sensitive hamster cell mutant with altered morphology.


A device for micro-injection of nanolitre quantities without precalibration: application in early amphibian development.


A comparison of 5-bromodeoxyuridine and thymidine incorporation into fertilized sea urchin eggs.


Effect of cycloheximide on pools of deoxyribonucleoside triphosphates.


Overlapping of normal and malignant mouse cells in pure and mixed cultures.


Human spermhormone.

Human spermhormone.


The binding of estradiol-17 beta to the bovine endometrial nuclear membrane.


Separation of the half-molecular weight nonidentical subunits of pigeon liver fatty acid synthetase by affinity chromatography.


Determination and physiologic effects of erythropoiesis inhibitors.


The temporal replication of ribosomal genes in synchronized Chinese hamster cells.


Real-space refinement of the structure of hen egg-white lysozyme.


Synthesis and turnover of nuclear and cytoplasmic polyadenylic acid in mouse L cells.


Energy refinement of hen egg-white lysozyme.


Behavioural effects of in utero administration of morphine.


Clinical significance of basilar artery aneurysms.


Similarity of morphine abstinence signs to thermoregulatory behaviour.


Measurement of regional cerebral blood flow. A comparison of the mass spectrographic and intra-arterial xenon 133 techniques.


Subarachnoid hemorrhage caused by rupture of a small superficial artery.


A cardiac risk screening program.

A cardiac risk screening program.


Prolonged twilight state and automatisms: a case report.


Levodopa and melanoma.

Levodopa and melanoma.


The teaching of exotic animal medicine in veterinary schools.


Stimulation of glucose metabolism by galactose in isolated adipocytes from rats.


Purification and properties of deoxyribonucleic acid-dependent ribonucleic acid polymerases from the slime mold Physarum polycephalum.


Rubella--high incidence of defects in children considered normal at birth.


Antifungal activity of some N-substituted anthranilic acid derivatives.


Studies on a serum substitute for mammalian cells in culture. 2. Analyses of fractionated peptone dialysate and the use of glycine peptides.


Methylphenidate antagonism of haloperidol, interaction with cholinergic and anticholinergic drugs.


Enhancement of methylphenidate-induced stereotypies by repeated administration of neuroleptis.


Influence of flupenthixol and flupenthixol-decanoate on methylphenidate and apomorphine-induced compulsive gnawing in mice.


Synthesis of compounds of potential value in the radioimmunoassay of 17 alpha-ethynylestradiol and mestranol.


Studies of the 3beta-hydroxysteroid oxidoreductase activity in rat ventral prostate.


Pharmacology of neuroleptics upon repeated administration.


A diploid rat liver cell culture. 2. Effect of aflatoxin B1 on ribonucleic acid synthesis.


Phagocytosis in the light-damaged albino rat eye: light and electron microscopic study.


Letter: Drug education programs.

Letter: Drug education programs.


Spinal cord damage in a newborn infant.

Spinal cord damage in a newborn infant.


Editorial: Towards medical audit.

Editorial: Towards medical audit.


Medical audit. Experience in the U.S.A.

Medical audit. Experience in the U.S.A.


Medical Audit. Necessary, but rigidity greatest danger.


Plasma cortisol determination: radioimmunoassay and competitive protein binding compared.


Assay of aspartate aminotransferase activity: effects of serum and serum proteins on oxalacetate decarboxylation and dialysis.


Optimal alpha-oxobutyrate concentration for assay of alpha-hydroxybutyrate dehydrogenase activity in normal and pathological sera at 30 degrees C.


Institute of laboratory animal resources.


The cellular events associated with regression and progression of murine (Moloney) sarcomas.


Yolk sac tumour of the ovary.

Yolk sac tumour of the ovary.


Comparison of 22 nm virus from human faeces with animal parvoviruses.


Referral relationships between internists and psychiatrists in fee-for-service practice: an empirical examination.


Dissociation of cell division stimulating capacity for Balb-c-3T3 from the insulin-like activity in human serum.


Resetting of tubulo-glomerular feedback sensitivity by dietary salt intake.


Electrogenic sodium pump in arterial smooth muscle cells.


Electrochemical potentials of potassium in proximal renal tubule of rat.


Electrical resistance of cell membranes in Necturus kidney.


Number of nephrons in hypertrophic kidneys after unilateral nephrectomy in young and adult rats. A functional study.


Intracellular potentials in the isolated human cornea.


Postpartum amenorrhea, diabetes insipidus and galactorrhea. Report of a case and review of the literature.


The contribution of the shivering hind leg to the metabolic response to cold of the young ox (Bos taurus).


New molecular complexes of methadone, its congeners and some other opiates with copper and iron.


Ceruloplasmin and alkaline phosphatase levels in cord serum of term, preterm, and physiologically jaundiced neonates.


Galactorrhea-amenorrhea syndrome associated with heroin addiction.


Regulation of antibody response in vitro. 8. Multiplicity of soluble factors released from carrier-specific cells.


Predictors of clinical performance.

Predictors of clinical performance.


Training in child psychiatry: a model of medical undergraduates.


Suicide and self-assault: an introductory course for medical students.


Intracellular location of specific antibodies reacting with human lymphocytes.


Cumulative cytostatic effect of ICRF 159.


Two-stage malignant transformation of rat fibroblasts in tissue culture.


Proceedings: The composition of rabbit skeletal muscle relaxing factor.


Temperature-sensitive mammalian cell line blocked in mitosis.


Toxic action of a phalloidin-albumin conjugate on cells with a high protein uptake.


Evidence against a genetical component to performance on IQ tests.


Simultaneous Mg, Ca, P, K and Cl analysis in rat tubular fluid. IV. During acute phosphate plasma loading.


Simultaneous Mg, Ca, P, K, Na and Cl analysis in rat tubular fluid. 3. During acute Ca plasma loading.


Urate excretion and urine flow in a lithium-induced diabetes insipidus rat model.


Twenty-four-hour rhythms of rectal temperature in humans: effects of sleep-interruptions and of test-sessions.


Length-dependent autogenetic inhibition of extensor gamma-motoneurones in the decerebrate cat.


Autointerference in infectious hematopoietic necrosis virus of salmonid fish.


The pattern of virus-specific peptide synthesis in rabbit cells infected with eastern equine encephalitis virus and its response to interferon.


Effect of perphenazine treatment of rats on serum ovarian and adrenal steroids.


Effect of photoperiod on time of blastocyst implantation in the rat.


Letter: Damage to schistosomula of Schistosoma haematobium in vitro by immune baboon and human sera and absence of cross-reaction with Schistosoma mansoni.


Proceedings: Egg membranes of Simuliidae.


Proceedings: Mastomys natalensis as a host for Dipetalonema viteae.


Proceedings: Serological tests for schistosomiasis with a purified egg antigen.


Retention of intravaginal sponge pessaries by cattle.


Association of influenza virus proteins with cytoplasmic fractions.


Transformation of a hamster embryo cell line (Nil) with a host-dependent mutant of adenovirus type 5.


Plasma progesterone during pregnancy in the mouse.


Iodinated FSH: components and their properties.


Antidromic and orthodromic activation of epileptic neurons in neocortex of awake monkey.


Occurrence of two cleavages preceding inactivation of bovine temporary trypsin isoinhibitor A.


Glycosphingolipid beta-galactosidases. I. Standard assay procedures and characterization by electrofocusing and gel filtration of the enzymes in normal human liver.


Characterization of Wolfgram proteolipid protein of bovine white matter and fractionation of molecular weight heterogeneity.


Choline acetyltransferase. Inhibition by thiol reagents.


Isolation and purification of the photoreceptor pigment associated with phototaxis in Dictyostelium discoideum.


Electrophoretic analysis of human brain-specific proteins obtained by affinity chromatography.


Insulin adsorption by glass infusion bottles, polyvinylchloride infusion containers, and intravenous tubing.


Mixed IgG-IgM cryoglobulinemia with follicular pustular purpura.


Choriocarcinoma metastatic to skin.

Choriocarcinoma metastatic to skin.


Does thyroid substance improve response of breast cancer to surgical castration.


Primary mediastinal choriocarcinoma in the male.


Observations on the development of subaortic stenosis following pulmonary artery banding.


Survival of transferred C57BL mouse embryos: effects of age of donor and recipient.


Relative ineffectiveness of exogenous as compared with endogenous testosterone in combating hypercholesterolemia.


Simple methods of rabbit hemolytic complement component assays.


Concomitant effects of insulin on surface membrane conformation and polysome profiles of serum-starved BALB-C 3T3 fibroblasts. By scanning and transmission electron microscopy we have shown that insulin rapidly reversed changes in surface membrane conformation and polysome profile induced by the transfer of actively growing Balb/c 3T3 fibroblasts from a serum-containing to a serum-free medium. Morphometric analysis of polysome profiles revealed a 94% aggregation of total f ribosomes during logarithmic growth. This figure fell to 78% after 18 h of serum starvation. The number of f ribosomes per unit area of cytoplasm also fell. 1 h of insulin treatment restored aggregation to 92% and increased the number of f ribosomes per unit area of cytoplasm by 22%. Scanning electron microscopy of logarithmically growing cells revealed an abundance of surface microvilli, whereas serum starvation promoted a smooth surface with few microvilli. After 1 h of insulin treatment, microvilli reappeared with a distribution and subcellular organization characteristic of exponential growth. This study shows the combined and rapid effect of insulin on the regulation of polysome formation and the promotion of a specific surface membrane conformation in cultured cells. The observations are consistent with the knowledge that insulin, acting on the surface membrane, can influence such parameters as membrane transport, and the rates of protein and RNA synthesis.


Sexual maturation in bulbectomized female rats.


Proceedings: Interrelations between oestrogens and prostaglandin F concentrations in the utero-ovarian venous plasma of the ewe.


Proceedings: The ultrastructure of the corpus luteum in relation to the mechanism of progesterone secretion.


Proceedings: Herd mating activity in cattle.


Proceedings: Superovulation in the cow following treatment with PMSG and prostaglandin F 2alpha.


Proceedings: Biochemical studies on Fallopian tube secretions.


Proceedings: Contractility of ovarian follicles from sheep in vitro.


Proceedings: The transport of spermatozoa in ewes treated with steriod hormones. The report cites the results of three experiments designed to determine the effect of estrogen treatment on spayed and entire ewes.  In the spayed ewes, estrus was induced by progesterone priming followed by an injection of estroidal benzoate.  Measurements at the twelth hour showed a far greater accumulation of spermatozoa in the mid and cranial cervix with dosages of 90 mcg than with 30 mcg.  At the 24 hour mark, no measurable difference occurred.  In the entire ewes, estrus was controlled using progestagen-impregnated sponges with subsequent administration of 1 mcg or 5 mcg/day of estradiol-17beta.  At the 2 hour mark, little effect was observed in the number of spermatozoa entering the caudal cervix though a marked effect was found in the number traversing the cervix into the uterus.  At 24 hours, there were no differences between estrogen treated and non-treated ewes in the cervix and uterus.  The numbers in the fallopian tubes reflected the numbers found in the uterus and cranial cervix at the 2 hour mark.  Estrogen treatment markedly reduced these numbers.  Entire ewes also received 25 mcg/day estrogen during the normal luteal cycle.  At 2 hours, there was no measurable effect in the caudal cervix but numbers were reduced in the mid and cranial cervix.  At 24 hours, numbers in the fallopian tubes reflected this result.  The report concludes that the sub-fertility in ewes is mostly due to changes in the cervical environment following estrogen treatment during the progestational phase, resulting in impaired transport of spermatozoa to the uterus.


Proceedings: Fertility after surgical insemination with frozen boar semen.


Proceedings: FSH, LH and testosterone levels in the rat from birth to sexual maturity.


Proceedings: Effects of liveweight of Border Leicester x Merino ewes and breed of ram ox fertilization in flock-mated sheep.


Proceedings: Oestrogen biosynthesis in the ovine conceptus.


Proceedings: Hormonal changes occurring in cattle following the administration of prostaglandin F 2alpha.


Proceedings: Effect of exogenous progesterone injected within the first 5 days after mating on conception in ewes.


Proceedings: Effect of exogenous progesterone on the ovarian cycle of ewes.


Proceedings: The effect of the mode of administration of prostaglandin F 2alpha on the synchronization of oestrus in cattle.


Proceedings: Luteal function in the cyclic sow after infusion of prostaglandin F 2alpha through a uterine vein.


Carcinoma in situ of the bladder with associated prostatic involvement.


Surface differences in cells of proximal and distal canine urethra.


Complete regression of metastatic tumors of the adult with antimitotic treatment.


Treatment of urethral strictures by intralesional infections of steroids, internal urethrotomy and intubation with silastic catheter.


Bulbar perforation during periocular injection of corticosteroids.


Toxoplasma infection and abortion in sheep associated with feeding of grain contaminated with cat faeces.


Morphology and content of gonadotrophic hormones in the hypophysis of white mice after trypan blue injections.


Levels of hormones in the serum of cycling beef cows.


Ponies vs. steers: microbial and chemical characteristics of intestinal ingesta.


[Influence of extrinsic factors on the development of the bulboventricular loop of the chick embryo].


Cortical-nuclear interactions in cephalopod development: cytochalasin B effects on the informational pattern in the cell surface.


Development in vitro of mouse embryos from the two-cell egg stage to the early somite stage.


Effects of cytochalasin B on meiosis and development of fertilized and activated eggs of Sabellaria alveolata L. (Polychaete Annelid).


Relationship between the amount of the 'germinal plasm' and the number of primordial germ cells in Xenopus laevis.


Infant feeding.

Infant feeding.


Porcine xenografts in the treatment of mitral valvular disease in children.


Human acid phosphatase in somatic cell hybrids. The human enzyme, lysosomal acid phosphatase ACP2, is expressed in nan-rodent somatic cell hybrids as a dimeric molecule. The human-rodent heteropolymer, as well as the human and rodent homopolymer, is associated with lysosomes in these cells. The genes specifying lysosomal acid phosphatase ACP(2) and LDH A are syntenic.


Haemostatic plug formation in the rabbit mesentery. A methodological study.


Proceedings: Masculine behaviour in geldings.


Proceedings: The role of prostaglandins in animal breeding.


Proceedings: Cystic ovarian disease in cattle: a changing clinical pattern?


Characterization of pathogenic and nonpathogenic strains of Mycoplasma meleagridis: in ovo and in vitro studies.


Chromatography of rare basic amino acids.


Extraction of RNA from mammalian tissue culture cells.


Gas chromatographic determination of sodium dodecyl sulfate.


A simple, rapid, and quantitative radiometric assay of acetylcholinesterase.


The effect of RNA upon the removal of RNase by phenol treatment.


Determination of manganese in biological materials by atomic absorption spectroscopy.


Properties and activity of the lipopolysaccharide-receptor from human erythrocytes.


Interaction of phospholipase A2 and its zymogen with divalent metal ions.


Budgerigar-fancier's lung: a report of a fatal case.


Histidine at the active site of phospholipase A2.


Purification and properties of acid phosphatase I from the cellular slime mold Polysphondylium pallidum.


Further studies on the use of synthetic prostaglandin analogues for inducing luteolysis in mares.


Conditioning of amphetamine-induced behaviour in the albino rat.


Isolation of canine prolactin by anterior pituitary organ culture.


Dose-dependent selective facilitation of response-contingent light-onset behavior by d-amphetamine.


In vitro cultivation of Theileria lawrencei-infected lymphoblastoid cell lines derived from a buffalo (Syncerus caffer).


Establishment of Theileria parva-infected lymphoblastoid cell lines using homologous feeder layers.


The effect of cell-free staphylococcal toxin on the mammary gland of the mouse.


Anaemia in trypanosomiasis: studies in rats and mice infected with Trypanosoma brucei.


The pathology of Trypanosoma brucei infection in the rat.


Editorial: PSRO an invalid concept.

Editorial: PSRO an invalid concept.


Industrial medicine as an instrument of community care.


Association monthly meetings support continuing education.


Vistas in correctional nursing.

Vistas in correctional nursing.


Retinitis pigmentosa.

Retinitis pigmentosa.


Social change and occupational health nursing.


The effect of resting potential on the electrical activity of canine cardiac Purkinje fibers exposed to Na-free solution or to ouabain.


Intracellular potassium in the distal tubule of the adrenalectomized and aldosterone treated rat.


A statistical appraisal of the results of the metabolic profile tests on 191 herds in the B.V.A.-A.D.A.S Joint Exercise in Animal Health and Productivity.


Androgen steroids as an aid to the detection of oestrus in pig artificial insemination.


The replenishment of the juxtaglomerular renin store after temporary renin depletion. An electron-microscopic and functional study.


Influence of additional methyl groups in the N-epsilon-amino position of lysine on the renal handling.


Effect of temporal and spatial temperature gradients on the ampullae of Lorenzini.


Immediate behavioral responses of an echinoderm to ionizing radiations.


Exercise acidosis as cause of electrolyte changes in femoral venous blood of trained and untrained man.


Effects of isolation on retrograde amnesia produced by ECS in multiple trial learning.


Fighting behavior in female mice following chronic androgen treatment during adulthood.


A severe spinal deformity in a cape buffalo calf (Syncerus caffer) similar to "short spine lethal" of Angus cattle (Bos taurus).


Rats and mice together: the predatory nature of the rat's mouse-killing response.


Attachment behavior in thirteen-month-old, opposite-sex twins.


Neutral sugars from the hyaluronate-peptide of vitreous humor.


Degradation of cysts of Hartmannella culbertsoni by culture filtrates of Alternaria sp.


Cholesterol solubility in model bile systems: implications in cholelithiasis.


Cytotoxic cardenolides from Acokanthera longiflora Stapf. and related species.


Binding of a new antitumor agent, thalicarpine, to DNA.


Which dog breeds develop what behavior problems?


Studies on human sexual development. II. Fetal and maternal serum gonadotropin and sex steroid concentrations.


Simplified radioimmunoassay for serum aldosterone utilizing increased antibody specificity.


Radioimmunological characterization of human thyrotropin and its subunits: applications for the measurement of human TSH.


The nocturnal rise of plasma testosterone in pubertal boys.


Letter: Modification of therapy for exacerbation of seizures during menstruation.


Importance of the urinary tract in imperforate anus.


Angiography in the diagnosis of liver tumours.


Various concepts in the aetiology of recurrent urinary tract infections in girls.


Relationship between body weight and gonadotrophin excretion in anorexia nervosa and obesity.


Amanita muscaria and the thunderbolt legend in Guatemala and Mexico.


Characteristics of an influenza mutant temperature-sensitive for viral RNA synthesis.


The components of barley stripe mosaic and related viruses.


The polypeptides of adenovirus. VI. Early and late glycopolypeptides.


Biogenesis of poxviruses: further evidence for inhibition of host and virus DNA synthesis by a component of the invading inoculum particle.


Replication of influenza virus in chick embryo fibroblasts after inhibition of host cell macromolecular synthesis by frog virus 3.


The new morality re-evaluated: a psychiatrist's point of view.


Proceedings: Accentuation of chlorambucil effect by various additives on rat tumour cells in culture.


Proceedings: Factors influencing the establishment of human tumour cells as a xenograft.


Proceedings: Mechanism of action studies with IRCF 159: effects on the growth and morphology of BHK-21S cells.


Studies on unidentified growth factors. 2. Progressin, a growth factor for chicks.


Protein digestibility of a feed mixture in relation to the protein digestibility of the individual protein components.


Treatment of diabetic maculopathy by argon-laser.


Editorial: Vinyl chloride and cancer.

Editorial: Vinyl chloride and cancer.


Maltese dilution, chromosome 9, and audiogenic seizures in DBA-2 mice: experimental evaluation.


Correction to the amino acid sequence of porcine motilin.


Pharmacological protection against swine stress ulcer.


Serum cholesterol esterification in human liver disease: role of lecithin-cholesterol acyltransferase and cholesterol ester hydrolase.


Role of bile acids in the activation of trypsinogen by enterokinase: disturbance of trypsinogen activation in patients with intrahepatic biliary atresia.


Hemagglutinin in cell walls of Chlamydia psittaci. Intact purified elementary bodies (EB) of Chlamydia psittaci agglutinate chicken erythrocytes in low titer, whereas homogenates of EB and of EB cell walls agglutinate at much higher titers depending on the extent of disruption by shaking and sonication. The hemagglutinin is contained in the cell envelope and can be purified with cell wall fractions. Treatment of cell wall with sodium dodecyl sulfate completely inactivated the hemagglutinin. Purified hemagglutinin was found to have an identical polypeptide composition to EB cell walls. Preparations of purified reticulate forms, the reproductive intracellular form of the organism, were almost totally devoid of hemagglutinin.


Evaluation of a solid phase radioimmunoassay (Ausria-125) for the detection of hepatitis B antigen (Australia antigen) in two clinical materials. A solid-phase radioimmunoassay (Ausria-125) was compared to an immunoelectro-osmophoresis method in detecting hepatitis-B antigen (HBAg). The radioimmunoassay detected HBAg in approximately 230 times higher dilutions than the immunoelectroosmophoresis method. In cases of acute hepatitis HBAg could be detected for about 70% longer after the onset of jaundice using radioimmunoassay compared with immunoelectroosmophoresis. Of 138 patients with acute hepatitis, who were HBAg-negative by immunoelectroosmophoresis, 23 (17%) were positive by radioimmunoassay. The specificity of the positive results with this test was investigated by neutralization tests with human antiserum to HBAg.


Latex agglutination test for detection of Australia antigen (HB-Ag) among blood donors and patients. The application of the latex test for the detection of Australia antigen (Au-Ag) was investigated. Reagents from two commercial sources were compared with the electrophoresis method with regard to sensitivity and specificity using samples from blood donors, hospital patients, and plasma fractions. Discordant results were further investigated by electron microscopy and radioimmunoassay. Differences were noted in the results between these reagents and the significance of the findings together with suggestions for minimizing false positive results are discussed.


Number and distribution of ridges in the cuticle of Nippostrongylus brasiliensis (Travassos, 1914) (Nematoda: Heligmosomatoidea).


Torulopsis glabrata urinary tract infection treated with 5-fluorocytosine. Two diabetic patients with symptomatic urinary tract infection by Torulopsis glabrata were successfully treated with two-week courses of 5-fluorocytosine.


Dipetalonema viteae in the experimentally infected jird, Meriones unguiculatus. I. Insemination, development from egg to microfilaria, reinsemination, and longevity of mated and unmated worms.


Canine filariasis in northeastern Kansas.


Dipetalonema viteae in the experimentally infected jird, Meriones unguiculatus. II. Microfilaremia in relation to worm burden.


Comparative biochemical studies of Litomosoides carinii, Dipetalonema viteae, and Brugia pahangi adults.


Letter: Sudden death in infancy (cot death).


A reexamination of Neochordodes occidentalis (Montg.) comb. n. (Chordodidae: Gordioidea): larval penetration and defense reaction in Culex pipiens L.


Editorial: Congenital toxoplasmosis, at long last . . .


The surgical construction of male genitalia for the female-to-male transsexual.


Cantharidin: potent feeding deterrent to insects. Cantharidin, the well-known terpenoid compound from the blood of blister beetles (and active principle of Spanish fly), is a feeding deterrent to insects, effective at a concentration of 10(-5) molar.


Serum induced lymphoid cell mediated cytotoxicity to human transitional cell carcinomas of the genitourinary tract. In some serums of patients with transitional cell carcinoma (TCC), a factor is present which induces lymphocytes from most donors with or without TCC to become cytotoxic against TCC-derived target cells. The induced cytotoxicity was directed against target cells derived from TCC's of the renal pelvis, ureter, and urinary bladder, but not against cells derived from normal kidney, bladder, testis, or skin or from renal cell carcinoma. Cytotoxicity occurred without complement but did not occur without effector cells.


Some observations on onchocerciasis in the Koinadugu District of Sierra Leone.


Abnormal electrical activity of the fetal brain and seizures of the infant.


Letter: Holoprosencephaly revisited.

Letter: Holoprosencephaly revisited.


Aspirin-induced thrombocytopenia on an immune basis.


Follow-up study of 100 cases of juvenile rheumatoid arthritis.


The release of iron from horse spleen ferritin to 1,10-phenanthroline. The rate of release of iron to 1,10-phenanthroline from ferritin fractions of different iron contents has been studied. The experimental results could be interpreted by a simple hypothetical model of the shape of the hydrous ferric oxide micelle at different iron contents, and reasonable correlation obtained between the rate of release and the calculated micelle surface areas. Initial rates of release did not correlate significantly with protein concentration.


Local changes in multiple unit activity induced by electrochemical means in preoptic and hypothalamic areas in the female rat.


The recognition and management of idiopathic hypertrophic subaortic stenosis in older patients.


Uptake of (6,7-3H)estradiol-17beta in ovariectomized rats, guinea pigs, and hamsters: correlation with species differences in behavioral responsiveness to estradiol. The amount of estradiol benzoate with progesterone required to induce lordosis in ovariectomized hamsters was determined to compare the responsiveness of hamsters to estradiol benzoate with that of rats and guinea pigs.  In addition,  the uptake and metabolism of tritiated estradiol in ovariectomized rats, guinea pigs, and hamsters was examined in an attempt to correlate species differences in behavioral sensitivity to estradiol with possible differences in  neural affinity for the steroid.  A dose of nearly 90 mg/kg was required to induce lordosis in 100% of the hamsters compared with the 2-5 mcg/kg which is effective in rats and guinea pigs.  In all 3 species, highest uptake of estradiol was in the uterus and anterior pituitary gland.  In the rat and guinea pig brains, the hypothalamus took up more estradiol than either the cortex or midbrain.  In the hamster, there were no consistent differences in brain uptake.  The affinity of the uterus, anterior pituitary, and hypothalamus of rats and guinea pigs for estradiol was greater than that of hamsters.  In all 3 species, estrone was the principal metabolite of estradiol found in the tissues.  The authors suggest that the higher the endogenous levels of a steroid, the less sensitive the animal is to that steroid.


Angiosarcoma of the premaxilla.

Angiosarcoma of the premaxilla.


Quantitative determination of alkaline phosphatase and inorganic phosphate in fetal and neonatal otic capsules of rats.


Letter: Neonatal and at-risk screening for deafness.


Measurement of serum LH during the proestrus critical period in rats exhibiting four- or five-day estrous cycles.


Microscopic observation of the chorioallantoic capillary bed of chicken embryos.


Genetic aspects of epilepsy.

Genetic aspects of epilepsy.


PSRO and options for the future.

PSRO and options for the future.


Caveats for PSRO's.

Caveats for PSRO's.


Cardiological aspects of the aging pilot.


Phospholipid hydration studied by deuteron magnetic resonace spectroscopy.


Credé prophylaxis and neonatal corneal infection with herpesvirus: a model.


Allergic reactions to pets.

Allergic reactions to pets.


Hypothalamic progesterone implants and facilitation of lordosis behavior in estrogen-primed ovariectomized guinea pigs.


Structure-antitumor activity relationships among quinone derivatives.


Digital processing of phonocardiograms: first results.


Influence of heating on the formation of ribosome couples and 80S initiation complex from the 40S and 60S ribosomal subunits from rabbit reticulocytes.


Editorial: Code on violence.

Editorial: Code on violence.


Prolonging life. 3. The hope in experiment.


Letter: Presence of prostaglandin A and F in fetal kidney.


Prostaglandin F concentrations in the utero-ovarian venous plasma of the sow during the late luteal phase of the oestrous cycle.


Radioimmunoassay of prostaglandin F-2-alpha in peripheral venous plasma from men and women.


Viroimmunoassay of prostaglandin F-2-alpha at the picogram level.


The preparation and characterization of prostaglandin E1 antiserum.


Simple direct radioimmunoassay of the F prostaglandins.


Post ovulatory changes in the concentration of prostaglandins in rabbit Graafian follicles.


16-aryloxyprostaglandins: a new class of potent luteolytic agent.


A controlled evaluation of lithium in the premenstrual tension syndrome.


Studies on ochratoxins.

Studies on ochratoxins.


Survival of Nippostrongylus brasiliensis larvae after freezing over liquid nitrogen.


Nippostrongylus brasiliensis: effects of immunity on the pre-intestinal and intestinal larval stages of the parasite.


Bovine pancreatic deoxyribonuclease D.

Bovine pancreatic deoxyribonuclease D.


The role of the lysyl residue at the active site of creatine kinase. Nuclear Overhauser effect studies.


Studies on a metal-binding protein of the sarcoplasmic reticulum.


Concanavalin A-induced alterations in sodium and potassium content of Ehrlich ascites tumor cells.


The binding of thrombin to the surface of human platelets.


Editorial: Instructional accountability: is it desirable or feasible?


The effect of contractile activity on fibrillation and extrajunctional acetylcholine-sensitivity in rat muscle maintained in organ culture. 1. The effect of contractile activity on the initiation of spontaneous action potentials (fibrillation) and on extrajunctional acetylcholine-sensitivity has been studied in single fibres in strips of previously denervated rat diaphragm maintained in organ culture for up to 10 days.2. Following removal of the diaphragm from the animal, fibrillation slowed and usually stopped altogether for about 24-36 hr. Thereafter, spontaneously active fibres were found in all cultured muscle strips.3. At any one time, about (1/4) to (1/3) of fibres impaled with micro-electrodes were active (defined as more than one action potential/10 sec), with a mean discharge frequency of 4.5/sec (range 0.1-24/sec).4. The duration of continuous activity in single fibres was, on average, 21-22 hr; a period of activity was followed by a longer inactive interval. Thus activity in single fibres is cyclical.5. Direct stimulation of fibrillating strips for 24 hr at 10/sec suppressed spontaneous activity for 1-3 days.6. Conversely, blockade of spontaneous activity with tetrodotoxin for 72 hr led to a two- to threefold increase in the number of fibrillating fibres when the drug was washed out; in some strips nearly all fibres became spontaneously active.7. The mean rate of activity of diaphragm fibres during normal breathing, determined by recording single units from the phrenic nerve in lightly anaesthetized animals, is about 18/sec.8. Direct stimulation of cultured diaphragm strips in a pattern similar to breathing for 7-8 days at an average rate of 10-12/sec (or 5/sec in some experiments), resulted in a marked reduction (about 95% in experiments at 10/sec) in extrajunctional sensitivity to ionophoretically applied ACh.9. Direct stimulation for 24 hr at 10/sec (comparable to a period of spontaneous activity) caused only a small reduction in extrajunctional ACh-sensitivity.10. We conclude that spontaneous activity in single fibres under these conditions occurs cyclically because activity, over a period of hours, inhibits the ability of the fibrillating fibre to initiate further action potentials. Repeated self-inhibition of spontaneous activity probably explains why denervated muscle fibres remain highly sensitive to extrajunctionally applied ACh.


Polyamine biosynthesis in human fetal liver and brain.


Immunochemical characteristics and rheumatoid factor inhibiting activity of enzymic subfragments from the C gamma3 homology region of human IgG.


Immunochemical detection of the VkIV subgroup.


Urethral stricture. Treatment with internal urethrotomy and silastic catheter intubation.


Lung metastases in prostatic carcinoma. Clinical significance.


Electronic bougie à boule calibration of female urethra. Technique of recording urethral elastic profile.


Letter: Bleeding angiokeratomas.

Letter: Bleeding angiokeratomas.


Studies on the maintenace of adult squid (Loligo pealei). I. Factorial survey.


Studies on the maintenance of adult squid (Loligo peali). II. Empirical extensions.


Metabolism during differentiation in the slime mold Physarum polycephalum.


Rapid identification of western equine encephalomyelitis virus.


Determination of free and bound plasma tryptophan by ultrafiltration.


Effect of human cerebral neuraminidase on hexosaminidase A.


Urinary D-glucaric acid assay by an improved enzymatic procedure.


The cell cycle and its relationship to aggregation in the cellular slime mold, Dictyostelium discoideum.


Chemical modifications of the major allergen of ragweed pollen, antigen E.


Biogenesis of Marek's disease (type II leukosis) virus in vitro: electron microscopy and immunological study. The kinetic events involved in Marek's disease herpesvirus infection of avian cell culture were investigated by assaying viral infectivity and antigenicity as well as by electron microscopy during the infectious cycle. The levels of viral infectivity and complement-fixing (CF) antigens revealed that the rates of appearance of infectious particles and CF antigens were not synchronous. Viral specific CF antigen could be detected 5 h after infection, whereas viral infectivity or the appearance of viral particles could be demonstrated only after 10 h of infection. High proportions of the recovered CF antigens during the various stages of the infectious cycle were found to be soluble and did not sediment with the virus particles. Cytological analysis of the developmental stages of the JM virus-infected cells by thin sectioning and electron microscopy revealed that at 8 h small particles approximately 35 nm in diameter appeared in the cell nuclei. The appearance of nucleocapsids occurred at 10 h, and these were of varying shapes; however, all were approximately 100 nm in diameter. At approximately 18 h postinfection, mature virus particles were observed. Viral maturation of the immature particles occurred by the acquisition of envelope from the inner leaflet of the nuclear membrane or from the cytoplasmic membrane of the cell.


Nature of mutations conferring resistance to 8-azaguanine in mouse cell lines.


The in vitro assembly of tubulins from sea-urchin eggs and rat brain: use of heterologous seeds.


A method for permanently recording microhemagglutination patterns.


Sensitivity in electron microscope autoradiography for 125I.


A slow fluctuation in the molecular conformation of a soya bean trypsin inhibitor.


Trial of radiolabeled antibody localization in metastases of a patient with a tumor containing carcinoembryonic antigen (CEA).


Predation and species diversity.

Predation and species diversity.


Choice of an estimate of genetic variance from twin data.


Mutarotases X. Anomer specific glucose transport in ascites tumor cells.


Transcription of reovirus RNA.

Transcription of reovirus RNA.


Studies on intravitreal blood vessels. 3. Effectiveness of intraocular diathermy on blood vessel closure; a comparison with argon laser.


Prediction of age and weight at puberty in beef heifers.


Effects of season, pregnancy and lactation on thyroxine turnover in the mare.


Plasma corticoids of Angus heifers in programmed circadian temperatures of 17 to 21 C and 34.


Puberal characteristics and early growth of Charolais bulls on high nutrient allowance.


Effects of a therapeutic modeling film on cognitive and emotional components of anxiety.


Aggressive behavior in immature ducklings.


Predation: separation of aggressive and hunger motivation by conditioned aversion.


Short-term effects of copulation, human chorionic gonadotrophin injection and non-tactile association with a female on testosterone levels in the male rat.


Alteration of 3 beta-hydroxysteroid dehydrogenase activity in rat ovaries during the oestrous cycle.


Sex differentiation and influence of castration on the production of 14CO2 from (U-14C)glucose in the limbic system.


Inhibition of the initiation of cellular DNA synthesis after reovirus infection. The synthesis of cellular DNA was measured in synchronized L cells after reovirus infection. Initiation of the synthetic phase of the cell cycle was completely inhibited in cells infected 8 h before the beginning of DNA synthesis.


Nutritional value of Egg Beaters compared with "farm fresh eggs".


Shythesis of reovirus oligo adenylic acid in vivo and in vitro. The formation of reovirus double-stranded (ds) RNA and of oligo adenylic acid (oligo A) is inhibited by 5 mug of actinomycin D per ml added at the time of viral infection. Viral proteins are synthesized and assembled into dsRNA-deficient particles under these conditions. The addition of cycloheximide to infected cells during the mid-logarithmic phase of viral replication terminates protein and dsRNA synthesis, but allows continued oligo A synthesis for about 1 h. The (3)H-labeled oligo A formed in the presence of cycloheximide is incorporated into particles whose density in CsCl is identical to that of reovirions. Using the large particulate or virus factory-containing cytoplasmic fraction of infected L-cells, we have established an in vitro system for the synthesis of oligo A. The in vitro product migrates slightly faster in sodium dodecyl sulfate acrylamide gels than marker oligo A. Oligo A synthesis in vitro continues for about 1 h, requires, the presence of only one ribonucleoside triphosphate (ATP), is not inhibited by DNase or RNase, but is abruptly terminated by the addition of chymotrypsin to the reaction mixture. Oligo A formed both in vivo and in vitro is released from the factory fraction by chymotrypsin digestion. The enzymes which catalyze the synthesis of oligo A, dsRNA, and single-stranded RNA all exhibit a similar temperature dependence with an optimum of approximately 45 C. These results indicate that oligo A is formed within the core of the nascent virion after the completion of dsRNA synthesis; they suggest that the oligo A polymerase is an alternative activity of the virion-bound transcriptase and that it is regulated by outer capsomere proteins.


A quantitative evaluation of HL-A gene products.


The current practices of Board-certified obstetricians and gynecologists in the United States. As reported to the American Board of Obstetrics and Gynecology in 1972-1973.


Sexual dysfunction after therapy for cervical carcinoma. Until the Kinsey report there had been very little published concerning sexual activity in the aging woman.  Since then other authors have stated that chronic illness or lack of a sexual partner rather than age have placed limitations on their sexual activity.  This study reports the effect of different modes of therapy for invasive carcinoma of the cervix on subsequent sexual function, and also tries to establish a correlation with the type of changes of the vaginal anatomy.  Radiotherapy alone had been performed on 28 patients, surgery alone on 32, and combined treatment on 15.  All were clinically free of cancer for 1 year after treatment was completed.  The youngest was aged 23 and the oldest 68.  Of the 28 patients treated with radiotherapy alone 22 had developed shortening or narrowing of the vagina sufficient to interfere markedly with sexual function.  Only 2 of the 32 surgically treated patients had such a sexual interference.  With combined treatment 60% showed some vaginal alterations and 33% sexual dysfunction.  Questioning of patients revealed the importance of sexual function in the lives of middle-aged women.  Therefore preference is expressed for radical surgery in the treatment of early carcinoma of the cervix because this mode of therapy interfers minimally with the sexual function.


Evaluation of type A botulinal toxin assays that use antitoxin to crystalline toxin. The type A botulinal toxin assay by the reverse passive hemagglutination procedure which uses antitoxin to crystalline toxin was examined for specificity. The analysis was based on the fact that crystalline type A toxin is a complex of neurotoxic protein (Aalpha) and a nontoxic protein (Abeta). By using these components, obtained in essentially pure forms, it was shown that the antitoxin to crystalline toxin has a significantly higher titer to Abeta than to Aalpha. When Formalin-treated red blood cells were sensitized with this antitoxin, the antibodies coupled to the cells were, for practical results, only anti-Abeta. When the suspension is reacted with dilutions of type A toxic solutions, the limiting dilutions are determined by Abeta and not by the neurotoxin, which should be the determinant if the assay is to measure toxicity. These observations may be pertinent to the development of serological assays for other botulinal toxin types.


Endometrial carcinoma associated with Sheehan's syndrome and stilbestrol therapy. At the age of 25, pregnant with her 2nd child, a woman was diagnosed as having pituitary necrosis resulting from hemorrhagic shock, in turn the result of a clotting defect caused by an amniotic fluid embolism.  For the next 17 years, her daily replacement therapy included 50 mg ma of cortisone, 120 mg of thyroid, and .5-1 mg of diethylstilbestrol given cyclically (21 days).  When an exploratory laparotomy was performed on her at age 42 because of abdominal mass,an endometrial adenocarcinoma and varying degrees of hyperplasia were found.  A total abdominal hysterectomy was performed, but a year later it became clear that the patient had diffuse carcinomatosis, and 2 months later she died.  Prolonged unopposed estrogen therapy is suggested as the cause of the endometrial cancer, rather than pituitary disturbance.


Soil ecology of Coccidioides immitis at Amerindian middens in California. Outbreaks of coccidioidomycosis and isolation of Coccidioides immitis have been reported from Amerindian middens. This study was undertaken to determine the most important ecological component(s) for the occurrence of C. immitis at archeological sites. Soils from 10 former Indian villages with no prior history of coccidioidal infection were collected and cultured. The physicochemical properties of the midden soils were compared with nonmidden soils and positive soils. The following theories for the sporadic distribution of the pathogen in the soil of the Lower Sonoran Life Zone were considered: (i) the Larrea tridentata (creosote bush) association, (ii) the preference for saline soils, (iii) isolation near rodent burrows, and (iv) animals as possible agents of dispersal. Results showed that a high percentage of the midden soils contained C. immitis, whereas none of the adjacent, nonmidden soils yielded the fungus. Physicochemical analyses revealed that the dark color and alkaline pH of the midden soils were due to past organic contamination. Repeated isolations were made from soils with low to moderate alkalinity. Alkalinity and sandy texture were consistent features of all soils in this study. However, the lack of any reports of nonsandy infested soils possibly indicates that the sandy texture and alkalinity may be factors in the distribution of this fungus. The organic content, soil parent material, and color were not important in the soil ecology. L. tridentata was not significant in the macroflora at the infested sites surveyed. Samples collected without reference to rodent burrows yielded a high percentage of recoveries. Animals, although not the major natural reservoir, cannot be ignored as possible factors in the ecology of C. immitis.


Enzymic synthesis of cerebroside from glycosylsphingosine and stearoyl-CoA by an embryonic chicken brain preparation.


In vitro metabolism of T-2 toxin.

In vitro metabolism of T-2 toxin. Incubation of T-2 toxin with the 9,000 x g supernatant fluid of both human and bovine liver homogenate resulted in conversion to a single, deacetylated product identified as HT-2 toxin. Metabolism is more rapid in human liver. HT-2 toxin was not produced when human plasma was the incubating medium nor was it produced by treatment of T-2 toxin with simulated gastric juice. T-2 toxin was stable in gastric juice for at least 1 h.


The amino acid sequence and configuration of tentoxin.


On the primary structure of pituitary bovine growth hormone.


Changes in cerebral carbohydrate metabolism in the rat after acute and chronic treatment with, and withdrawal of, methamphetamine.


Interaction between piperazine and chlorpromazine. The interaction between piperazine and chlorpromazine has been studied in rats and mice. Piperazine administered a few hours previously potentiated the action of chlorpromazine on the central nervous system. No such interaction was found between piperazine and prochlorperazine.


Modification of brain acetylcholine release by morphine and its antagonists in normal and morphine-dependent rats. 1 The spontaneous release of acetylcholine (ACh) from the cerebral cortex of control and morphine-dependent rats was investigated. The rate of resting output of ACh in morphine-dependent animals was lower than that in the control animals.2 Administration of naloxone and nalorphine to morphine-dependent rats was followed by a significant rise in the release of cortical ACh. In control rats no such increase in the release of ACh occurred after similar injections of narcotic antagonists.3 Injections of morphine produced a consistent decrease in the rate of spontaneous release of cortical ACh in the control rats, but similar injections in the dependent rats did not produce a decrease in the rate of cortical ACh release.4 The relevance of these results with regard to development of the narcotic abstinence syndrome is discussed.


Nascent DNA synthesis in ultraviolet light-irradiated mouse, human and Chinese hamster cells. The technique of alkaline sucrose gradient centrifugation was used to study newly synthesized DNA in control and ultraviolet light-irradiated mouse L, human HeLa, and Chinese hamster ovary cells. Nascent DNA molecular weight distributions did not appear to differ among the three cell lines for unirradiated cells. However, at short times after ultraviolet light irradiation, human HeLa cells appeared to synthesize more low molecular weight DNA than either mouse L or Chinese hamster ovary cells. Since this difference was not related to differences in either the rate of DNA synthesis or amount of ultraviolet damage in the irradiated cells it appeared to be a phenotypic characteristic of the cell lines tested. A parallel was noted for these three cell lines between an increase in the synthesis of low molecular weight DNA, detected on alkaline sucrose gradients, and cell killing as measured by the ability of irradiated cells to form colonies.


Diaminodichloroplatinum: a phase I study showing responses in testicular and other tumors.


Comparison of direct-current and radio-frequency-current lesions in the rostral hypothalamus with respect to sexual maturation in the female rat.


Comparison of lactoperoxidase- and thyroid peroxidase-catalyzed iodination and coupling.


Serum profiles of follicle-stimulating hormone, luteinizing hormone and prolactin during the estrous cycle of the hamster.


Effects of rewarming the bovine neurohypophysis in vitro: release of vasopressin and lactic dehydrogenase.


Therapist warmth as a factor in automated systematic desensitization.


Suicide and the representation of transparency and cross-sections on the Rorschach.


Purine-specific reapir of beta-propiolacton-induced DNA damage in mouse skin cells.


Double-replicating method for the freeze-fractured retina.


Bovine plasma progesterone levels at programmed circadian temperatures of 17 to 21 degrees C and 21 to 34 degrees C.


Apomorphine induced biting and fighting behaviour in reserpinized rats and an approach to the mechanism of action.


Complementation of a defect in the production of ribosomal RNA in somatic cell hybrids.


Are non-dividing cells present in ageing cell cultures?


President's page: professional standards review organization.


Cortical hypothermia is a sequela of electroconvulsive shock.


The conditioned emotional response (CER) as a baseline for the study of anti-anxiety drugs.


The general practitioner and the care of the dying patient.


Methylmercury exposure, mercury levels in blood and hair, and health status in Swedes consuming contaminated fish.


Effect of neonatal administration of androgen and estrogen on the vagina of the golden hamster.


Late macular complications of choroidal ruptures.


Study of the cerebral vascularization of the human fetus by transumbilical angiography.


Splenoportography: an assessment of its value and risk.


Fibroma virus-induced acid deoxyribonuclease in rabbit kidney cells.


Quantitative studies on the dependence of NDV penetration and elution on the attachment multiplicity.


A dilatometric study of the denaturation of bovine serum albumin by guanidine hydrochloride.


An unmethylated "3 SE" RNA in hamster mitochondria: a 5 S RNA-equivalent?


Sodium excretion after relief of urinary tract obstruction in children.


Effect of quinacrine on survival and DNA repair in x-irradiated Chinese hamster cells.


Effects of tryptophan deprivation on L1210 cells in culture.


Immunogenicity of "single peak" beef-pork insulin in diabetic subjects.


Evaluation of commercial rapeseed meal and Bronowski variety rapeseed meal in calf rations.


Comparative effects of tallow, lard and soybean oil, with and without supplemental cholesterol, on growth, tissue cholesterol and other responses of calves.


Labeled casein as an indicator of inhibited protein digestion in chicks fed raw soybean meal.


Effect of selenite on the toxicity of dietary methyl mercury and mercuric chloride in the rat.


Comparison of Bricker and Wallace methods of ureteroileal anastomosis in urinary diversions.


Cyclophosphamide and hemorrhagic cystitis.


A new theory of the innervation of bladder musculature. 4. Innervation of the vesicourethral junction and external urethral sphincter.


Reduction of acute alcoholic intoxication by alpha amino acids: glycine and serine.


Inhibition of normal clotting and Fletcher factor activity by rabbit anti-kallikrein antiserum.


Noise, vitamin A deficiency, and emotional behavior in rats.


Retinal dysplasia and rosettes induced by experimental intrauterine trauma.


Effect of pH, ionic strength and univalent inorganic ions on the reconstitution of aspartate aminotransferase. 1. The effect of pH change on the reconstitution of aspartate aminotransferase (EC 2.6.1.1), i.e. the reactivation of the apoenzyme with coenzyme (pyridoxal phosphate and pyridoxamine phosphate), was studied in the pH range 4.2-8.9 by using three buffer systems at concentrations ranging from 0.025 to 0.1m. 2. Although the profile of the reconstitution rate-pH curve in the range pH5.2-6.8 (covered by sodium cacodylate-HCl buffer) reflects the influence of the H(+) concentration on the reconstitution process, the profile of the curve in the pH ranges 4.2-5.6 and 7.2-8.25 (covered respectively by sodium acetate-acetic acid and Tris-HCl buffers) appears to be influenced by the ionic strength of the buffer. 3. The reconstitution is also influenced by univalent inorganic ions such as halide ions and, to a lesser extent, alkali metal ions, which are known to alter the water structure.


Reactivity of the active-centre lysine residue of rabbit muscle aldolase. The method of competitive labelling with [(3)H]acetic anhydride as the labelling reagent was used to determine the properties of the active-centre lysine residue of rabbit muscle aldolase. This residue is much less reactive than a normal exposed lysine residue towards this reagent, and its reactive properties did not parallel the pH-activity profile for aldolase. At higher pH values it became reactive, but this was shown to be due to disruption of the enzyme structure. The binding of the competitive inhibitor phosphate did not alter the reactive properties. It is concluded that the active-centre lysine has an apparent pK(a) greater than 11.5 and probably is made nucleophilic during the catalytic process, perhaps by proton abstraction.


Salt effects on the denaturation of DNA. 3. A calorimetric investigation of the transition enthalpy of calf thymus DNA in Na2SO4 solutions of varying ionic strength.


A study of the properties of hybrids of oxyhaemoglobin and deoxyhaemoglobin with two porphyringlobin species. The fluorescence of porphyringlobin is quenched on adding haemoglobin to its solutions. It is suggested that this result indicates the formation of hybrids (comprising a dimer of porphyringlobin and a dimer of haemoglobin) in which quenching occurs by energy transfer from the porphyrin to the haem groups of the protein. From an analysis of fluorescence quenching, dissociation constants were calculated for the hybrids of oxy- and deoxyhaemoglobin with the fast- and slow-moving porphyringlobin species isolated by chromatography on CM-Sephadex (Treffry & Ainsworth, 1974). The values obtained are: deoxyhaemoglobin-fast-moving porphyringlobin, 0.8x10(-9)m; deoxyhaemoglobin-slow-moving porphyringlobin, 5x10(-10)m; oxyhaemoglobin-fast-moving porphyringlobin, 0.8x10(-6)m; oxyhaemoglobin-slow-moving porphyringlobin, 1.2x10(-7)m. The rates of reactions of solutions of haemoglobin and porphyringlobin, containing hybrids, with the thiol reagent 4,4'-dithiodipyridine showed that the thiol groups of the hybrids deoxyhaemoglobin-fast-moving porphyringlobin and oxyhaemoglobin-slow-moving porphyringlobin react more slowly than expected on the basis of composition alone: this result indicates that the deoxy and slow-moving conformations are the more stable, imposing themselves partially on to the fast-moving or oxy dimer of the hybrid. Also the rate of the reaction of CO with deoxyhaemoglobin is decreased when slow-moving porphyringlobin is added to its solutions: this is reflected in a movement of the oxygen equilibrium curve of such a mixture to higher oxygen partial pressures. Similar experiments with deoxyhaemoglobin solutions containing fast-moving porphyringlobin, showed an initial increase in the rate of CO uptake. Correspondingly, the oxygen equilibrium curve of the mixture showed an increased affinity for oxygen. Approximate calculations to determine the oxygen equilibria of the hybrids indicate that a functional dimer retains co-operative characteristics even when the dimer accompanying it within the tetramer has the reacted conformation.


Lipid--DNA interactions. II. Phospholipids, cholesterol, glycerophosphorylcholine, spingosine and fatty acids.


Cooking chicken and turkey from the frozen and thawed states.


Interaction of Grignard reagents with coumarins. I. Novel 1,4-addition.


Rosette formation by a mouse fibroblast cell line.


Complete amnesia induced by ECS and complete recovery of memory following reinstatement treatment.


Absence of weight regulation in exercising hamsters.


Increased gastrin release following penetrating central nervous system injury.


Effect of atropine on basal and food-stimulated serum gastrin levels in man.


Action of colchicine on the chromosomes of the ascidian Botryllus schlosseri pallas.


Viscoelastic properties of mucus.

Viscoelastic properties of mucus.


Changes in serum antibody levels during treatment with grass pollen-tyrosine adsorbate.


Control of lysosomal acid phosphatase expression in man-mouse cell hybrids.


Contractile filamentous structures in Sertoli cells of the Greek tortoise (Testudo graeca)?


In vitro attachment of streptococci to the tooth surface. The ability of Streptococcus strains to adhere to the tooth surface in vitro was investigated. Polished enamel slabs, with and without acquired pellicles, were incubated with buffer suspensions of oral streptococci, and attached bacteria were counted under a microscope using incident light. Low numbers of bacteria adhered to uncoated enamel; the presence of an acquired pellicle significantly enhanced the attachment of all strains tested. The adherence of Streptococcus sanguis was significantly greater than that of Streptococcus salivarius, and both of these strains adhered in greater numbers than did Streptococcus mutans. When bacteria were suspended in whole saliva, the adherence of S. salivarius and S. mutans was inhibited, whereas the adherence of S. sanguis was enhanced in some experiments and inhibited in others. The adherence of S. sanguis and S. salivarius was consistently inhibited by parotid fluid; this inhibitory effect persisted after thorough washing and resonication of the bacterial cells. Incubation in oral fluids was associated with the attachment of bacterial clumps to the pellicle, and parallel investigation revealed agglutination of S. sanguis and S. salivarius by whole saliva and, in particular, parotid fluid. The results are discussed in terms of surface microecology, and are related to the development of dental plaque.