Metabolism, excretion and toxicoloty of methylchloroform in acute and subacute exposed rats.


Investigations on the effects of diazepam in acute experimental intoxication with fluostigmine.


Lead acetate toxicity in rats in relation to age and sex.


Pharmacokinetics, cardiovascular and metabolic actions of cyclohexylamine in man.


The stimulation of diffusion of adenine nucleotides across bimolecular lipid membranes by divalent metal ions.


The inactivation of acetylcholinesterase by trimethyloxonium ion, an active-site-directed methylating agent.


A pathway of chitosan formation in Mucor rouxii: enzymatic deacetylation of chitin.


Carnitine synthesis in rat tissue slices.


On the frequency of arginine in proteins and its implications for molecular evolution.


Photosynthetic control and photophosphorylation in photosystem II of isolated spinach chloroplasts.


Reaction of BCNU (1,3-bis (2-chloroethyl)-1-nitrosourea) with polycytidylic acid. Substitution of the cytosine ring.


On the mRNA induced conformational change of AA-tRNA exposing the T-pse-C-G sequence for binding to the 50S ribosomal subunit.


Transmembrane electron transfer in an enzyme-phospholipid complex.


Proton magnetic resonance study of the switch between the two quaternary structures in high-affinity hemoglobins in the deoxy state.


Ficins (EC 3.4.22.3). Purification and characterization of the enzymatic components of the latex of Ficus glabrata.


Phosphorylation of the sarcoplasmic reticulum membrane by orthophosphate through two different reactions.


Uridine phosphorylase, molecular properties and mechanism of catalysis.


Proflavine interactions with papain and ficin. II. Effects of dye binding upon reversible inhibition.


Biosynthesis of chlorosulfolipids in Ochromonas danica. Origin of primary and secondary hydroxyl groups determined by 18O incorporation in vivo.


Proflavine interactions with papain and ficin. I. Dye binding and its effects upon enzyme inactivation by N-alkylmaleimides.


Physical studies of N-acetoxy-N-2-acetylaminofluorene-modified deoxyribonucleic acid.


The conformation of the sodium complex of a biologically active analog of antamanide in the crystalline state.


Influence of globin structure on the state of the heme. I. Human deoxyhemoglobin.


Steroid 11beta-hydroxylation in beef adrenal cortex mitochondria. Binding affinity and capacity of specific (14C)steroids and for (3H)metyrapol, an inhibitor of the 11beta-hydroxylation reaction.


Kinetic mapping of the antibody combining site by chemical relaxation spectrometry.


Conformational transitions in glycogen phosphorylase reported by covalently bound pyridoxamine derivatives.


Calorimetric determination of the enthalpy and heat capacity changes for the association of haptoglobin with hemoglobin. I. Demonstration of two interacting systems.


Afferent projections in the abducens nerve: an intracellular study.


Reflex responses of sympathetic preganglionic neurones initiated by different cardiovascular receptors in spinal animals.


Electrophysiological chracteristics of chick embryo sympathetic neurons in dissociated cell culture.


Changes in neostriatal DA metabolism after carbachol or atropine microinjections into the substantia nigra.


Maturation-dependent alterations in (3H)GABA compartmentalization in neural tissue in vitro.


Biosynthesis of neurohypophysial proteins in rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain).


Specification of regenerating retinal ganglion cells in the adult newt, Triturus cristatus.


The effect of frontal eye field stimulation on unit activity in the superior colliculus of the cat.


Injection of radioactive materials into an identified axon of Aplysia.


Resolution and chromatographic configuration analysis of 2-hydroxy fatty acids.


Theoretical study of aliphatic chain structure in mono- and bilayers.


Evidence for an indirect sympathetic control of atrial stretch receptor discharge in the dog.


Mechanisms of renal release of renin by electrical stimulation of the brainstem in the cat.


Force-velocity and series elastic characteristics of smooth muscle from the hog carotid artery.


Lipid composition and metabolism of thromboatherosclerotic lesions produced by continued endothelial damage in normal rabbits.


Influence of experimental edema on metabolically determined blood flow.


Initiation of sustained rhythmic activity by single propagated action potentials in canine cardiac Purkinje fibers exposed to sodium-free solution or to ouabain.


Influence of right ventricular filling pressure on left ventricular pressure and dimension.


Interaction of vasopressin and the baroreceptor reflex system in the regulation of arterial blood pressure in the dog.


Human splanchnic and forearm vasoconstrictor responses to reductions of right atrial and aortic pressures.


Estimating the functional capabilities of sarcoplasmic reticulum in cardiac muscle. Calcium binding.


Norepinephrine uptake, smooth muscle sensitivity, and metabolizing enzyme activity in rabbit veins.


Microcirculation in the ventricle of the dog and turtle.


Pressures in cat mesenteric arterioles and capillaries during changes in systemic arterial blood pressure.


Effect of epinephrine on pressure, flow, and volume relationships in the systemic circulation of dogs.


Influence of temperature on the mechanical properties of cardiac muscle.


Inability of potassium canrenoate to convert experimentally induced ouabain arrhythmias in the canine heart.


Defective activation of clotting, fibrinolytic, and permeability-enhancing systems in human Fletcher trait plasma.


In vivo analysis of adrenergic receptor activity of dobutamine.


Regional coronary venous oxygen saturation and myocardial oxygen tension following abrupt changes in ventricular pressure in the isolated dog heart.


Nature of the gap phenomenon in man.

Nature of the gap phenomenon in man.


Determination of left ventricular preload and afterload by quantitative echocardiography in man.


Computer model of cardiac potential distribution in an infinite medium and on the human torso during ventricular activation.


Rapid, accurate technique for determination of carbon monoxide in blood.


Experimental production of rate-dependent bundle branch block in the canine heart.


Automated determination of serum hexosaminidase A by pH inactivation for detection of Tay-Sachs disease heterozygotes.


Effect of venous occlusion of the arm on the concentration of calcium in serum, and methods for its compensation.


Specific automated method for measurement of urinary hydroxyproline.


Column-chromatographic studies of isoamylases in human serum, urine, and milk.


Analysis for total serum thyroxine by equilibrium competitive protein binding on small, re-usuable Sephadex columns.


Automated fluorometric creatine kinase assay. Measurement of 100-fold normal activity without serum dilution.


Development and application of a radioimmunoassay for plasma glucagon.


Evaluation of a transformation method for estimation of normal range.


New method for measurement of guanidinosuccinic acid in serum and urine.


Comparative study of a micro-scale test for lead in blood, for use in mass screening programs.


Standardization in abnormal hemoglobin detection. An evaluation of hemoglobin electrophoresis kits.


Evaluation of the adaptation of the glucose oxidase-peroxidase-3-methyl-2-benzothiazolinone hydrazone-N,N-dimethylaniline procedure to the Technicon "SMA 12-60," and comparison with other automated methods for glucose.


Enzymatic blood glucose determination by colorimetry of N,N-diethylaniline-4-aminoantipyrine.


Urinary excretion of non-nitrogenous organic acids by healthy infants and children.


Increased uropepsinogen excretion in diabetes mellitus.


Interference with measurement of 3-methoxy-4-hydroxymandelic acid and 5-hydroxyindoleacetic acid by reducing metabolites.


Design of a portable solid-state hemoglobinometer.


Specific gravity of blood and plasma at 4 and 37 degrees C.


Improved automated method for determining serum albumin with bromcresol green.


Assessment of status riboflavin nutriture by assay of erythrocyte glutathione reductase activity.


Letter: Concerning on-column methylation of phenobarbital.


Letter: An improvement in lipid classes determination.


Letter: Fluorometric determination of propoxyphene.


Letter: T3 solid phase radioimmunoassay.


Letter: Free glycerol interference in triglyceride determinations: warning of a possible problem.


Retrograde amnesia initiated by low-level stimulation of hippocampal cytoarchitectonic areas.


Neuropil organization in the superior olive of the cat.


Rapid degeneration and regeneration of a whole skeletal muscle following treatment with bupivacaine (Marcain).


Effects of sensory stimuli on single cell activity in the septum of the cat.


Protection from lethal audiogenic seizures in mice by physical restraint of movement.


Analgesia produced by brain stimulation: evidence of a prolonged onset period.


An electrophysiological study of the effects of D-tubocurarine, atropine, and alpha-bungarotoxin on the cholinergic receptor in innervated and chronically denervated mammalian skeletal muscles.


Systematic variations in the conduction velocity of slowly conducting axons in the rabbit corpus callosum.


Properties of antidromically activated callosal neurons and neurons responsive to callosal input in rabbit binocular cortex.


Synapses and malnutrition: quantitative ultrastructural study of rat cerebral cortex.


Himasthla quissetensis: induced in vitro encystment of cercaria and ultrastructure of the cyst.


The secretory nature of the excretory gland cells of Strephanurus dentatus. 3. Proteinase inhibitors.


Immunity to Fasciola hepatica in the rat. Successful transfer of immunity by lymphoid cells and by serum.


Incorporation of 14C-amino acids by malarial plasmodia (Plasmodium iophurae). VI. Changes in the kinetic constants of amino acid transport during infection.


Fasciola hepatica: influence of extrahepatic adult flukes on infections and immunity in rats.


Nematospiroides dubius: mechanisms of host immunity. I. Parasite counts, histopathology, and serum transfer involving orally or subcutaneously sensitized mice.


Protein metabolism. 3. Relationship between albumin metabolism and elevated liver protein synthesis in the guinea pig infected with Trichostrongylus colubriformis.


Liver diseases in asymptomatic carriers of hepatitis B antigen.


Caroli's disease associated with congenital hepatic fibrosis and renal tubular ectasia. A case report.


Early changes in bile composition and gallstone formation induced by a high cholesterol diet in prairie dogs.


Canalicular bile flow and bromosulfophthalein transport maximum: the effect of a bile salt-independent choleretic, SC-2644.


Editorial: Toxic megacolon complicating ulcerative colitis: current therapeutic perspectives.


Letter: Infectiosity of HB Ag carriers?

Letter: Infectiosity of HB Ag carriers?


The semantics of augmentation.

The semantics of augmentation.


Toxic megacolon in ulcerative colitis.

Toxic megacolon in ulcerative colitis.


Studies on the distribution and degradation of heptadecapeptide, big, and big big gastrin.


Chronic intestinal coccidiosis in man: intestinal morphology and response to treatment.


Effect of selective and proximal gastric vagotomy on serum gastrin.


Psychic control of gastric acid: response to anticipated feeding and biofeedback training in a man.


Distribution of blood flow to the layers of the small bowel in experimental cholera.


Serous otitis media in children.

Serous otitis media in children.


Effect of deoxycholate, indole, and endotoxin on organ cultures of rabbit jejunum.


Significance and detection of conductive lesions in children with multiple handicaps.


Testing for hearing loss with auditory evoked responses--successes and failures.


Evaluation the perception and articulation of phonemes of children, ages 5 to 8.


The effects of reward on types of stuttering.


Comparison of articulation severity ratings of s and r by lower-, middle-, and upper socioeconomic groups.


Dysfluency characteristics identified by listeners as "stuttering" and "stutterer".


The specification of the retino-tectal projection in the chick.


Impulses in dorsal spinal nerve rootlets in cats and rabbits arising from dorsal root ganglia isolated from the periphery.


The mode of innervation of portions of the anterior and posterior pretectal nuclei of the rabbit by axons arising from the visual cortex.


DNA constancy in neurons of the human cerebellum and spinal cord as revealed by Feulgen cytophotometry and cytofluorometry.


Fiber composition of the posterior lateral-line nerve of goldfish, investigated by electrophysiological and microscopical techniques.


Measurement of nerve fiber diameters in the region of the dorsal spinocerebellar and spinocervical tracts in the cat.


Preparation of the domains and domain-containing fragments of the human gamma-chain.


A simple method for liquid scintillation counting of 125-iodine and 51-chromium used in antigen binding and cytotoxicity studies.


Separation and concentration of respiratory syncytial virus (RSV) antigens.


Effect of lesions of cortical motor areas on acquisition of conditioned eye blink in the cat.


Variation in gustatory nerve fiber discharge pattern with change in stimulus concentration and quality.


Selective firing by cat pontine brain stem neurons in desynchronized sleep.


Medial geniculate body: unit responses in the awake cat.


Blockage of inhibition by ammonium acetate action on chloride pump in cat trochlear motoneurons.


Structural study of inferior olivary nucleus of the cat: morphological correlates of electrotonic coupling.


Electrotonic coupling between neurons in cat inferior olive.


Subphrenic abscess.

Subphrenic abscess.


Effect of intravenously administered calcium on serum gastrin and gastric secretion in man.


Experimental perineal colostomy with voluntary control.


A rational approach to venous thrombectomy.


Anabolic effects of human growth hormone and high caloric feedings following thermal injury.


Efficacy of adrenalectomy in treatment of patients with metastatic cancer of the breast.


Sepsis presenting as acute respiratory insufficiency.


The relationship between Doppler ultrasound assessment and angiography in occlusive arterial disease of the lower limbs.


Nonparasitic cysts of the liver.

Nonparasitic cysts of the liver.


Blunt trauma to the subclavian artery.

Blunt trauma to the subclavian artery.


Editorial: The education and training of surgeons and medical ethics.


Editorial: The use of heparin in arterial reconstructions.


The therapeutic hydrophilic contact lens in treatment of corneal edema.


Editorial: Two separate worlds of discourse.


Spray-can roulette.

Spray-can roulette.


Myopathy in primary hyperparathyroidism.


Delayed complications of snowmobile injuries due to blunt trauma to the abdomen. Two case reports.


Clinical use of lithium.

Clinical use of lithium.


Diagnostic efficacy of myocardial creatine phosphokinase using polyacrylamide disk gel electrophoresis.


Evaluation of a direct-reading reflectometer for neonatal hypoglycemia screening.


Automated simultaneous determinations of titratable acidity and ammonium ion in urine.


Drug-induced bleeding.

Drug-induced bleeding.


Experience with a thrombin clotting time assay for measuring heparin activity.


Ultrastructure of an anaplastic carcinoma of the thyroid.


The derivation of so-called "giant-cell" and "spindle-cell" undifferentiated thyroidal neoplasms.


Non-ossifying fibroma. Report of an intact lesion.


Malignant transformation of condyloma acuminatum. A light microscopic and ultrastructural study.


Papillary cystadenoma within the testis.


Capillary basement membranes in muscle in glucose intolerance of the chemical diabetes type.


Letter: Tissue thromboplastin and activated partial thromboplastin reagents.


Letter: Protamine-corrected thrombin time.


Myokymia and facial contraction in brain stem glioma. An electromyographic study.


Central nervous system intoxication from mercurous chloride laxatives. Quantitative, histochemical, and ultrastructural studies.


Botulism. Ten-year experience.

Botulism. Ten-year experience.


Levodopa, carbidopa, and pyridoxine in Parkinson disease. Metabolic interactions.


Ischemic cerebral edema. Distribution of water in brains of cats after occlusion of the middle cerebral artery.


Ischemic cerebral edema and the blood-brain barrier. Distributions of pertechnetate, albumin, sodium, and antipyrine in brains of cats after occlusion of the middle cerebral artery.


Ependymitis in mumps virus meningitis. Electron microscopical studies of cerebrospinal fluid.


Asymptomatic demyelinated plaque in the spinal cord.


Editorial: Antibiotics and farmers.

Editorial: Antibiotics and farmers.


Editorial: Looking after schizophrenics.


Editorial: Abdominal decompression in pregnancy.


Editorial: Urethral prolapse in childhood.


Biochemical basis of malignant hyperpyrexia. Pharmacologically-induced muscle contracture in vitro has been used as a model to study the biochemical basis of malignant hyperpyrexia. In 15 susceptible subjects halothane, succinylcholine, and potassium chloride all produced an abnormal muscle contracture, and the caffeine-induced contracture was greater than normal. The contractures were reproducible only in the presence of extracellular calcium ions. The fact that such dissimilar pharmacological stimuli all induced contracture in the affected muscle suggests that the essential abnormality in the muscle cell in malignant hyperpyrexia is an impaired binding of calcium ions to the membranes of the sarcoplasmic reticulum and the sarcolemma. Exposure of these membranes to halothane, succinylcholine, and other anaesthetic agents then leads to a rapid and abnormally large release of calcium into the myoplasm, which in turn gives rise to all the clinical features of the syndrome.


Identification of susceptibility to malignant hyperpyrexia. While the serum level of creatine phosphokinase is useful as a screening test for malignant hyperpyrexia it does not provide certain identification of susceptible individuals. A much more accurate prediction may be made by pharmacological testing in vitro of muscle biopsy specimens. Individuals susceptible to malignant hyperpyrexia have muscle with heightened sensitivity to halothane, caffeine, succinylcholine, potassium chloride, and temperature change. Use of this test allows separation of susceptible individuals from those not at risk in families of patients who have experienced malignant hyperpyrexia.


Blood and neoplastic diseases. Blood formation and the pathogenesis of anaemia.


Awareness and experience of general practitioners of selected drug interactions. The awareness of general practitioners of selected adverse drug interactions has been assessed. The drugs studied included adrenergic neurone blockers, warfarin, antidiabetic agents, and monoamine oxidase inhibitors. The findings must be interpreted with caution but they suggest that there is a clear need to improve the effectiveness of communication of information about adverse drug interactions if unnecessary iatrogenic disease is to be avoided.


Letter: Who is the dental anaesthetist of the future?


Acute terminal ileitis and Yersinia infection. Acute terminal ileitis was for many years thought to be due only to Crohn's disease, though most patients found at laparotomy to have this condition did not progress to the chronic form of Crohn's disease. A case of acute terminal ileitis due to Yersinia pseudotuberculosis is presented here to draw attention to another, perhaps predominant, cause of this condition.


Letter: Innocent praecordial murmurs in children.


Letter: Cervical cone biopsy and fertility.


Letter: Meningococcal disease.

Letter: Meningococcal disease.


Letter: Cervical injury and prostaglandins.


Letter: Clinical diagnosis of Reye's syndrome.


Letter: Carcinoid pulmonary embolism and cor pulmonale.


Letter: Urinary F.D.P. excretion in glomerulonephritis.


Letter: Chronic brucellosis.

Letter: Chronic brucellosis.


Letter: Intermittent calf compression in prevention of deep venous thrombosis.


Letter: Circadian rhythm of cortisol secretion in elderly and blind subjects.


Letter: Reactions to immunization.

Letter: Reactions to immunization.


Letter: Misdiagnosis in Still's disease.


Letter: Alcoholism and its identification.


Letter: Training for general practice.

Letter: Training for general practice.


Letter: British academy of psychopharmacology.


Letter: Epidemic neuromyasthenia.

Letter: Epidemic neuromyasthenia.


Letter: Attitudes to abortion.

Letter: Attitudes to abortion.


Letter: Alternatives to animal experiments.


Letter: Effects of entonox on respiratory function.


Letter: Cot deaths.

Letter: Cot deaths.


Letter: Can I have an ambulance, doctor?


Letter: Vaginal cytology in pregnancies associated with congenital fetal defects.


Letter: High-dose frusemide in renal failure.


Letter: Care of the coronary patient.

Letter: Care of the coronary patient.


Letter: Hypertension and myocardial infarction.


Editorial: Transvestism and transsexualism.


Editorial: Severed fingers.

Editorial: Severed fingers.


Editorial: One people in Jamaica.

Editorial: One people in Jamaica.


Editorial: Standards in jeopardy.

Editorial: Standards in jeopardy.


Indomethacin and platelet aggregation in chronic glomerulonephritis: existence of non-responders. Indomethacin given to adults with glomerulonephritis usually reduces their urinary excretion of protein and fibrinogen/fibrin-related (F.R.) antigen. Nevertheless, non-responders exist. Platelet aggregation is significantly more strongly inhibited by indomethacin in good responders than in nonresponders. This supports the hypothesis that the reduction of urinary excretion of F.R. antigen during indomethacin administration is related, at least in part, to inhibition of intrarenal platelet aggregation and of the subsequent fibrin deposition.


Meningioma mimicking features of a phaeochromocytoma.


"Destroying our seed corn".

"Destroying our seed corn".


Surgical reduction of tumour bulk in management of abdominal Burkitt's lymphoma. The results of a retrospective study of the value of reductive surgery in the treatment of abdominal Burkitt's lymphoma are reported. Nine patients had almost complete removal of the tumour, 16 had little over half of the tumour removed, and 43 underwent biopsy only. All patients subsequently received chemotherapy. There was a highly significant difference in the proportion of patients achieving a sustained durable remission (P > 0.0001) and a significant difference in survival (P > 0.05) between the group having almost complete removal and the partial resection group. Partial resection gave no advantage over no surgery. We believe that whenever possible complete removal of the abdominal tumour should be attempted regardless of the presence of extra-abdominal tumour; but unless at least 90% of the tumour can be removed there is no advantage in partial resection in terms of response to subsequent chemotherapy. In particular the removal of one of two involved ovaries can no longer be recommended. The implications of these results are related to cancer treatment strategy.


Letter: Attitudes to abortion.

Letter: Attitudes to abortion.


Letter: The nurse in group practice.

Letter: The nurse in group practice.


Letter: Patients' attitudes to medical students in general practice.


Letter: Isolation system for general hospitals.


Letter: Accidental poisoning in children.


Letter: Dangerous patients.

Letter: Dangerous patients.


Letter: Rebound migraine.

Letter: Rebound migraine.


Letter: Laxative-induced diarrhoea.

Letter: Laxative-induced diarrhoea.


Letter: Withdrawal symptoms after stopping phenelzine?


Letter: Coping with minor casualties.

Letter: Coping with minor casualties.


Letter: Malaria in the United Kingdom.

Letter: Malaria in the United Kingdom.


Letter: Intensive care: allocation of resources.


Letter: Thromboembolism and oral contraceptives.


Letter: Atropine poisoning.

Letter: Atropine poisoning.


Letter: Drugs affecting oral contraceptives.


Letter: Pre-eclampsia and the kidney.

Letter: Pre-eclampsia and the kidney.


Letter: Cello scrotum.

Letter: Cello scrotum.


Survival after hepatic artery ligation: present controversy and rationale of management, with a case report.


Ileal bypass and cholesterol absorption.


Recurrent posterior dislocation of the shoulder.


Classic cholelithiasis and choledocholithiasis in a 10-year-old girl.


Food bolus obstruction.

Food bolus obstruction.


Perfusion of the isolated lung: the role of glucose and insulin in the perfusate.


Enuresis, fire setting, and animal cruelty: a useful danger signal in predicting vulnerability of adolescent males to assaultive behavior.


A study of outcome of special schooling of emotionally disturbed children.


Contents of day and night dreams of emotionally disturbed adolescents.


Siblings of retarded children: a population at risk.


Jordan left-right reversal test: a study of visual reversals in children.


Getting parents to follow advice: the art of communication.


Bronchial asthma: new definition for an old disease.


Relapsing fever, 1973, in Grand Canyon National Park.


The Beckwith-Wiedemann syndrome. The exomphalos-macroglossia-gigantism syndrome.


Renal cell carcinoma in a child. A case report.


Adsorption of Hg (II) by ferric hydroxide.


Sedimentary fluorite in Tampa Bay, Florida.


Effects of lead chloride on chloroplast reactions.


A preliminary evaluation of a discrete sample analyzer for chemical analysis of water.


Paper recycling energetics: some Canadian experience.


Mercury contamination of vegetation due to the application of sewage sludge as a fertilizer.


Field evaluation of the four synthetic components of the sex pheromone of Spodoptera littoralis and their improvement with an antioxidant.


Editorial: Freedom of the news media.

Editorial: Freedom of the news media.


Stimulatory effects on growth and photosynthesis of the toxic red tide dinoflagellate, Gonyaulax tamarensis, with the addition of nitrilotriacetic acid (NTA) N(CH2COOH).


C9 heterochromatin during the first meiotic prophase of human foetal oocyte.


Further studies on colchicine-resistant mutants of Chlamydomonas reinhardi.


DNA synthesis turned on in unfertilized sea urchin eggs by treatment with NH4OH.


Effects of various ionic media on extraction of soluble nuclear proteins and on nuclear ultrastructure.


Chromatin and histones in mealy bug spermatogonia. In situ alteration of template availability in hetero- and euchromatin by a synthetic polyanion.


Transitional changes during stimulation in the electroretinogram of visually deprived rats.


Potassium: a factor necessary for the expression of mating reactivity in Paramecium caudatum.


Metabolic studies on small molecular weight nuclear RNA components in human lymphocytes.


Spontaneous and reflexly evoked laryngeal abductor and adductor muscle activity of cat.


Deployment of optic nerve fibers is determined by positional markers in the frog's tectum.


Substrate utilization by the denervated rat hemidiaphragm.


Electrical conductivity in cat cerebellar cortex.


Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma.


Effects of oxygen deprivation on incorporation of (U-14C)-glucose into macromolecules of guinea pig cerebral cortex slices.


Management of fractures of the larynx.

Management of fractures of the larynx.


Esthesioneuroblastoma--report of three cases.


Video cassette education program.

Video cassette education program.


Achalasia of the esophagus.

Achalasia of the esophagus.


Choice of preschool vision test.

Choice of preschool vision test.


Heparin found useful in migraine attacks.


Irreversible thermodynamics as an approach to study biomembranes.


Phthalazine. IV. New results on catalytic hydrogenation of phthalazon.


Renovating a dietary department.

Renovating a dietary department.


Law forum: hospital held liable for breach of 47-year-old free-bed contract. Nonlocal physician allowed to testify as medical expert. Nurse not held to be agent to physician.


Nursing reorganization at Borgess Hospital, Kalamazoo, Mich; optimizing nurse effectiveness.


HMOs: organizational and financial models.


The challenge of the new rite of anointing.


Criteria for evaluating and choosing a computer system.


Employe organizational attachment and job expectations.


Editorial: Biocommunications as a profession.


A student nurse's experiences with a terminal patient; grief and dying.


Fluorescein angiography--tests on a broad-band filter combination.


A simple technique to improve contrast of low-contrast electron micrographs.


A rapid, simple and inexpensive technique for black-and-white positive slides.


The long term care of the patient suffering from cerebral palsy. I.


The Health Maintenance Organization Act of 1973.


The physician and vocational rehabilitation of the disabled patient.


On the structure, function, and distribution of filament bundles in apothecial cells of the fungus Ascobolus stercorarius.


The anterior medial gland in the mouse nasal septum: an uncommon type of epithelium with abundant innervation.


Single crystal x-ray diffraction studies of Southern bean mosaic virus.


Congenital absence of the dens of axis.

Congenital absence of the dens of axis.


Proceedings: Growth problems in cervical injuries.


Traumatic spinal paralysis in children.

Traumatic spinal paralysis in children.


Proceedings: Must appendicitis be still considered as a rare complication in paraplegia?


Proceedings: Perforated peptic ulcer in paraplegia.


Proceedings: Accidental perforation of the rectum.


Marijuana responses in rats: influence of castration or testosterone.


Inhibition of mammalian fertilization in vitro by membrane vesicles from seminal plasma.


Erythropoiesis in pyridoxine deficient mice.


Similar response of spontaneously hypertensive and normotensive rats to adrenal enucleation.


Comparison of magnesium deficiency in the rat and mouse.


Buffer-dependent actions of insulin and halothane on glucose metabolism in isolated rat atria.


Factors influencing the development of indomethacin-induced intestinal ulcers in the rat.


Method for determining incorporation of acetate into citrate.


Concentration dependent inhibition of hepatic gluconeogenesis by insulin.


Chemical composition of atherosclerotic lesions of aortas from pigeons with naturally occurring or cholesterol-aggravated atherosclerosis.


Studies on vaccination of infants against influenza with influenza hemagglutinin.


Streptolysin O: suppression of its antigenicity by lipids extracted from skin.


Comparative metabolic responses of rat kidney and liver to acute doses of fluoride.


Activities of pyruvate carboxylase and propionyl CoA carboxylase in rat tissues during biotin deficiency and restoration of the activities after biotin administration.


Sodium metabolism and intrarenal distribution of nephron glomerular filtration rates in the unanesthetized rat.


Enhancement of uridine uptake in the kidney papilla by urea.


Suppression of adjuvant arthritis by penicillamine in pyridoxine deficient rats.


Effect of dietary fat on the release rate of cholesterol from swine erythrocytes.


Stabilisation of mouse and human interferons by acid pH against inactivation due to shaking and guanidine hydrochloride.


Liver and brain nucleic acids and brain RNA synthesis in suckling rats fed dieldrin.


Measurement of renal blood flow with radioactive microspheres.


Placentitis and abortion in cattle inoculated with chlamydiae isolated from aborted human placental tissue.


Isolation of RNA species from HeLa cells infected with respiratory syncytial virus.


Test of the safety valve function of the renal lymphatic vessels.


Regulation of a specific uterine protein by estrogen and progesterone in ovariectomized rabbits.


Transductal fluxes of anions in the rat pancreas.


Biliary excretion of phenol red by Wistar and Gunn rats.


Local vascular effects of alkalosis in the dog gracilis muscle.


Effects of plasma electrolyte abnormalities on total peripheral resistance and other hemodynamic parameters in dogs.


Effect of antilymphocyte serum on influenza virus infection in mice.


Carbon-mercury bond cleavage in blood of rats fed methyl mercuric chloride.


Enhancement by cultured fibroblasts of reparative collagen synthesis in rats.


Adverse effect of gel filtration on the function of human platelets.


"Craving" and relapse to drink.

"Craving" and relapse to drink.


Stress, affect and craving in alcoholics. The single case as a research strategy.


Hyperlipemia in alcoholics.

Hyperlipemia in alcoholics.


Drugs, drug dependance and the concept of plasticity.


Employed alcoholics treated voluntarily and under constructive coercion. A follow-up study.


Production of fatty liver with dietary ethanol despite orotic acid supplementation.


Attitudes of hospital staff toward alcoholics and drug addicts.


Deaths associated with alcohol in Georgia, 1970.


Alcoholism and violent death.

Alcoholism and violent death.


Correlates of drinking and drunkenness among high-school students.


Changing ideas of alcohol use among Navaho Indians.


Alcohol problems in Yugoslavia and Russia: some observations of recent activities and concerns.


Effects of whisky on heart conduction in cardiac patients.


The role of a medical audit in assessing management of alcoholics with acute pancreatitis.


Validity of self-reports of alcohol-related arrests by alcoholics.


Psychiatric illness in husbands of alcoholics.


Fatal crashes among Michigan youth following reduction of legal drinking age.


Proceedings: Alcohol studies and Anthropology.


Letter: Drug education.

Letter: Drug education.


Letter: Birth order and alcoholism.

Letter: Birth order and alcoholism.


Effects of food deprivation and fluid sweetening on alcohol consumption by rats.


Emotionality and alcohol selection in deer mice (Peromyscus maniculatus).


Alcohol effects on delayed responding by rats.


Alcohol and conflict resolution. A theoretical analysis.


"Reversible" organic brain syndrome in alcoholics. A psychometric evaluation.


Discrimination of low blood alcohol levels and self-titration skills in social drinkers.


Candida in the blood culture. What to do next?


[Blood dyscrasias with long-term phenylbutazone therapy].


Medullary carcinoma of the thyroid. An endocrine disease.


Ballooned mitral valve. A common clinical disorder which may mimic other heart disease.


The wall.

The wall.


The influence of normal serum components on lymphocyte-mediated cytolysis in vitro.


Relative immunogenicity of H-2 and other membrane components in xenoimmunization.


Aneurysm resulted from mesoarteritis with giant cells at the peripheral artery.


Regional myocardial ischemia--causes, prediction and prevention.


Axillo-mesenteric bypass for acute mesenteric infarction.


Relation between fine structure and function of the corpus luteum of wild ruminants.


Morphological variations of the sinus durae matris of the Indian buffalo (Bubalus bubalis).


Massive basilar artery aneurysms.

Massive basilar artery aneurysms.


Adenoacanthoma of the small bowel. Report of a case.


Carcinogenicity in mice of some fatty acid methyl esters. 1. Skin application.


Dating of the human corpus luteum of menstruation using histological parameters.


Value of free metaphase cell preparations in cytophotometric study of experimental skin carcinogenesis.


Studies on the histogenesis of experimentally induced cervical carcinoma.


Cytologic studies in cases with carcinoma in situ and microinvasive carcinoma of the uterine cervix.


Chromosome and nuclear DNA study of a uterine adenocarcinoma and its metastases.


A stereological study of intrahepatic bile ducts. 4. Congenital hepatic fibrosis.


On the presence within tumours of clones that differ in sensitivity to cytostatic drugs.


Cell clones with different sensitivity to cytostatic drugs in methylcholanthrene-induced mouse sarcomas.


Effects of homozygosity of the nude (NU) gene in three inbred strains of mice. A detailed study of mice of three genetic backgrounds (BALB-c, C3H, C57-BL-6) with congenital absence of the thymus (nude mice) at a stage in the gene transfer.


Brain volume in acromegaly. An encephalographic investigation.


Cortical bone mass in acromegaly.

Cortical bone mass in acromegaly.


Angiographic abnormalities in combined myositis ossificans and digital ischemia of the hand. Report of a case.


Pharmacoangiography on the left gastric artery in oesophageal varices.


Functional isotope phlebography of lower extremities.


Scintigraphy of the parasternal lymphatics in the rabbit using technetium-99m sulfide colloid.


Grading of osteoporosis by skeletal roentgenology and bone scanning.


Instrument for isotope determination in vivo of mineral content of the jaw bone.


Aorta, heart and lung vessels in idiopathic pulmonary emphysema related to pulmonary function.


Intravenous cholegraphy and peroral contraceptives. A preliminary report.


Carcinoma of the gallbladder. A review of 158 cases.


The genetic structure of a tribal population, the Yanomama Indians. X. Agreement between representations of village distances based on different sets of characteristics.


A maximum-likelihood method for estimating the disease predisposition of heterozygotes.


Analysis of family resemblance. I. Introduction.


Characterization of a phosphoglycerate kinase variant associated with hemolytic anemia.


Annotation: the analysis of variance and the analysis of causes.


Phosphoglycerate mutase isozyme marker for tissue differentiation in man.


Letter: Acromial dimples: a benign familial trait.


Letter: Computerized assignment of genotypes within screened pedigrees.


Letter: A case of primary amenorrhea associated with X-autosomal translocation (46,X,t(Xq minus;5q plus)).


Perinatal mortality rates: a fourteen-year survey in a metropolitan community hospital.


Physical characteristics of the gravida and their association with birth weight and perinatal death.


An experiment in medical education.

An experiment in medical education.


The effect of radiation therapy on pelvic lymph node involvement in stage I carcinoma of the cervix.


Multiphasic fetal monitoring. A preliminary evaluation.


Destructive operations on the fetus. Review of literature and application in 10 cases of neglected dystocia.


A clinical and pathologic review of ovarian stromal hyperplasia and its possible relationship to common diseases of the female reproductive system.


Invasive carcinoma of the vulva.

Invasive carcinoma of the vulva.


The incidence of unsuspected asymptomatic thrombophlebitis of pelvic veins associated with hysterectomy.


Progestational agents and blood coagulation. VI. Relationship of ABO blood types to changes induced by oral contraceptives. Data from the author's previous studies regarding changes which occur in coagulation and fibrinolytic levels in the blood of women using oral contraceptives have been compared with ABO blook groups in 307 women.  Although a tendency toward hypercogulability in group A was noted, it was not statistically significant.  Patients had been treated with 4 different dosage combinations of estrogen and progestins over periods varying from 3 months to 24 months.  The steroid therapy had increased the levels of activity of some of the coagulation and fibrinolytic factors regardless of progestin component dosage.  No differences among blood groups was shown.


Detection of a diesterase in endometrial material from normal women.


Experience with three different models of the Copper T intrauterine contraceptive device in nulliparous women. The copper T (TCu) intrauterine device (IUD) has been found to be an effective and well tolerated method of contraception for nulliparous women.  Tatum theorized that his TCu's effectiveness was directly related to the amount of copper used.  471 nulliparous women had the TCu 200 device inserted; 347 nulliparous women received the TCu 300; 785 nulliparous women had the TCu 380 inserted.  (The figures indicate the sq mm of copper surface area in each device.)  Discontinuation rates at 12 months were 25.8, 19.3, and 18.1 per 100 women respectively.  Respective pregnancy rates were 1.7, .6, and .2 per 100 women at 12 months.  The results of this study suggest that the effectiveness in pregnancy prevention is greater with increased amounts of copper.


Synthesis of "long", hydrophilic, protein-cross-linking reagents.


A computerized fluorescence anisotropy spectrometer.


Adenosine tetraphosphate analysis: polyethyleneimine (PEI) thin layer purification and firefly-extract liquid scintillation quantitation.


A rapid spectrophotometric assay for catechol-O-methyltransferase.


A technique for isolating pure, viable parenchymal cells and their nuclei from rat mammary gland.


Nonenzymatic exchange of tritium from (5-3H) deoxyuridylate in the thymidylate synthetase assay.


Direct enzymatic procedure for the determination of liver glycogen.


Analysis of methylthiohydantoins of amino acids by gas-liquid chromatography of their trimethylsilyl derivatives.


Quantitative analysis of DNA in sea urchin eggs and subcellular distribution of DNA in the eggs.


Isolation and identification of the carcinogen N-hydroxy-2-fluorenylacetamide and related compounds by liquid chromatography.


A highly sensitive adenylate cyclase assay.


PEI-cellulose thin-layer chromatography. Product studies of the creatine kinase and pyruvate kinase reactions.


Application of the flame photometric sulfur detector to the gas-chromatographic analysis of trimethylsilylated methylthiohydantoins of amino acids.


Use of fluorescamine in the chromatographic analysis of peptides from proteins.


Rapid and sensitive determination of sphingosine bases and sphingolipids with fluorescamine.


Effect of N,N,N',N'-tetramethylethylenediamine on the migration of proteins in SDS polyacrylamide gels.


Thermal denaturation of nucleic acids in polyacrylamide gels.


Group separation of ribonucleotides, ribonucleosides, and purine and pyrimidine bases on polyacrylamide gel columns.


Sedimentation coefficients of higher polysomes from rat liver and the localization of polysomes not resolved by gradient analysis.


Differential rates of passage of amino acids through an ultrafiltration membrane.


Interaction of quinidine and propranolol on vulnerability of the ventricle to electrical fibrillation.


The cardiovascular mode of action of phentolamine as studied by non-invasive methods.


Delta9-tetrahydrocannabinol and some CNS depressants: evidence for cross-tolerance in the rat.


Effects of hyperbaric conditions on the responses of animals to central nervous system stimulants and depressants.


The effect of delta9-tetrahydrocannabinol pretreatment on ketamine thiopental or CT-1341--induced loss of righting reflex in mice.


Effects of d-amphetamine and secobarbital on key press rates in normal humans.


Action of strychnine and central depressants on the cerebello-rubral system.


The influence of spinal cord transection on the capacity of digitoxin to induce cardiotoxicity.


Potentiation of the biphasic bradykinin response of the guinea-pig ileum.


Effects of probenecid on the distribution, elimination, and passage into milk of benzylpenicillin, ampicillin and cloxacillin.


Sensory peripheral pathway from extrinsic eye muscles.


Extraocular proprioceptive and trigeminal projections to the Purkinje cells of the cerebellar cortex.


Effect of natural stimulation of macular labyrinthine receptors on the discharge pattern of brain stem respiratory neurones.


Color coding of B-scan ultrasonograms.

Color coding of B-scan ultrasonograms.


Acute optic neuropathy. Treatment with diphenylhydantoin.


Ocular manifestations of Reye syndrome.

Ocular manifestations of Reye syndrome.


Subretinal pigment migration. Effects of cryosurgical retinal reattachment.


Malignant teratoid medulloepithelioma of the optic nerve.


Unusual ocular involvement in acute disseminated histiocytosis X.


Electric cataracts. 3. Animal model.

Electric cataracts. 3. Animal model.


Bilateral Duane syndrome. Occurrence in three successive generations.


Psychovisual disturbances in glaucoma. A study of temporal and spatial summation.


Letter: Retinal tears.

Letter: Retinal tears.


Letter: Instrument penetrates cornea.

Letter: Instrument penetrates cornea.


Silicone tubing in canalicular obstructions. A preliminary report.


Letter: Corneal color change noted.

Letter: Corneal color change noted.


Letter: Hydrophilic lens pigmentation.

Letter: Hydrophilic lens pigmentation.


Lipid autoxidation in human skeletal muscle.


Serum creatine phosphokinase isozymes in hypothyroidism, convulsion, myocardial infarction and other diseases.


Modification of Laurell's crossed immunoelectrophoresis with special gel chamber.


A method for the determination of volatile organic acids in aqueous solutions and urine, and the results obtained in propionic acidaemia, beta-methylcrotonylglycinuria and methylmalonic aciduria.


Relationship between theophylline concentration in plasma and saliva of man.


Studies on the urinary acidic metabolites excreted by patients with beta-methylcrotonylglycinuria, propionic acidaemia and methylmalonic acidaemia, using gas-liquid chromatography and mass spectrometry.


Validity of screening methods for drugs of abuse in biological fluids. I. Heroin in urine.


Plasma concentrations of diazepam and of its metabolite N-desmethyldiazepam in relation to anxiolytic effect.


Propranolol enhancement of hypoglycemic sweating.


Effect of practolol on blood pressure and renin release in man.


Intravenous digoxin as a bioavailability standard: slow infusion and rapid injection.


Blood levels of practolol after oral and parenteral administration and their relationship to exercise heart rate.


Dose-effect relations of marijuana smoking on various physiological parameters in experienced male users. Observations on limits of self-titration of intake.


Methemoglobin formation in analgesic nephropathy.


Clinical biostatistics. XXVII. The derangements of the 'range of normal'.


Proceedings: Location of the genes for 5S RNA in the human chromosome complement.


Proceedings: Evidence for synteny between the human loci for triose phosphate isomerase, lactate dehydrogenase-B, and peptidase-B and the regional mapping of these loci on chromosome 12.


Proceedings: Regional localization of the human genes for thymidine kinase, lactate dehydrogenase-A, and esterase-A.


Proceedings: Summary of human gene map.

Proceedings: Summary of human gene map.


Proceedings: Synteny relationships of beta-D-N-acetylhexosaminidase A and B in somatic cell hybrids.


Proceedings: Linkage data on AcP1 and MNSs.


Proceedings: Exclusion of peptidase-A structural gene locus from the q11q21 region of chromosome 18 in man.


Proceedings: Localization of the structural gene for human peptidase-A to chromosome 18.


Proceedings: A modified technique for separating mouse and Chinese hamster from human HPRT and human and Chinese hamster from mouse APRT.


Proceedings: Report of the Committee on the Genetic Constitution of Chromosome 1.


Proceedings: Localization of gene markers to regions of the human X chromosome by segregation of X-autosome translocations in somatic cell hybrids.


Proceedings: Synteny of human genes for glutamic oxalacetic transaminase and hexokinase in somatic cell hybrids.


Proceedings: An (Xq+; 9p-) translocation suggests the assignment of G6PD, HPRT, and PGK to the long arm of the X chromosome in somatic cell hybrids.


Proceedings: Evidence for synteny between the human loci for fumarate hydratase, UDP glucose pyrophosphorylase, 6-phosphogluconate dehydrogenase, phosphoglucomutase1, and peptidase-C in man-Chinese hamster somatic cell hybrids.


Proceedings: Localization of the 5S ribosomal RNA genes in the human genome.


Proceedings: Assignment of the genes for the human interferon system to chromosomes 2 and 5.


Proceedings: Assignment of adenosine deaminase to chromosome 20.


Proceedings: Probable genetic linkage between the loci for the Lewis blood group and complement C3.


Proceedings: Cell cultures with chromosomal aberration--July 1973--available from the Human Genetic Mutant Cell Repository.


Proceedings: Total lods for linkage analyzed by the New York Blood Center and Birmingham Computer Programs.


Proceedings: Report of the Committee on the Genetic Constitution of Autosomes other than Chromosome 1.


Proceedings: Report of the Committee on the Genetic Constitution of the X Chromosome.


Proceedings: Report of the Committee on Genetic Markers. Gene markers for mapping the human genome.


Proceedings: Supplement to list of genetic markers with synonyms and references not included in the report of Committee on Genetic Markers.


Proceedings: Report of the Committee on In Situ Hybridization.


Proceedings: Report of the Committee on Chromosome Markers.


Proceedings: Report of the Committee on Terminology.


Proceedings: HL-A loci and chromosome 6.


Proceedings: Analysis of the mitochondrial enzymes citrate synthase (EC 4.1.3.7) and malate dehydrogenase (EC 1.1.1.37) in human-mouse somatic cell hybrids.


Proceedings: Confirmation of the synteny of the human genes for cytoplasmic isocitrate dehydrogenase and cytoplasmic malate dehydrogenase and assignment to chromosome 2.


Proceedings: Mouse-human somatic cell hybrids utilizing human parental cells containing a (14;22) translocation: assignment of the gene for nucleoside phosphorylase to chromosome 14.


Proceedings: Synteny of the IDH-1 and MDH-1 gene loci in man and probable assignment to chromosome 2.


Proceedings: Hexosaminidase B: assignment of a locus involved in its expression to chromosome 5 in man.


Proceedings: Assignment of a locus involved in the expression of hexosaminidase A to chromosome 7 in man.


Cortical blindness as a manifestation of basilar artery occlusion.


The electrophoretic pattern of cerebrospinal fluid proteins in the cutis verticis gyrata and mental retardation syndrome.


Amyloidotic polyneuritis of type 3 (Iowa-Van Allen).


Prostaglandins V: (plus or minus) 10 beta-hydroxyprostaglandins.


NIH and the scientist--and a crisis of apathy.


Why FASEB? Mission, operations, and financing.


Letter: Peer review.

Letter: Peer review.


Biomedical information services and the future.


New approach to dissemination of scientific information.


University of Sheffield Biomedical Information Service.


Communication of scientific information at a cancer research institute.


Biological handbooks: compilation, processing, and dissemination of data.


Access to the biomedical literature through services produced at Chemical Abstracts Service.


Information support for the biomedical sciences.


Computer-based retrieval services at The National Library of Medicine.


Excerpta Medica's system for the automated storage and retrieval of biomedical information.


The future of scientific communication.

The future of scientific communication.


Proceedings: Symposium. Newer candidates for essential trace elements: an introduction.


Proceedings: Sterol carrier protein hypothesis.


Proceedings: Recent dietary trace element research, exemplified by tin, fluorone, and silicon.


Proceedings: Nickel: a new essential trace element.


Proceedings: Vanadium as an essential nutrient.


Inotropic effects of Nifedipine: a new coronary dilating agent.


Clinical and audiometric experiments to assess the analgesic effect of pentazocine.


Comparative studies on the absorption of ampicillin trihydrate and potassium ampicillin.


Haemorrhagic lesions of lungs induced by reptilase and epsilon-aminocaproic acid in rats.


Studies on the action of certain pharmacological agents on tardive dyskinesia and on the rabbit syndrome.


The effect of "Noxyflex" (Noxytioline) on the behaviour of animals which have been infected intraperitoneally with suspensions of faeces.


Editorial: The health education course.

Editorial: The health education course.


Editorial: Mental health programs: choosing the right model.


The college health education course: its status and future.


The health educator: "Neither fish, nor flesh, nor good red herring".


The social health of disadvantaged black college students.


Mexicans-Americans.

Mexicans-Americans.


How come you guys in mental health don't see more patients?


A follow-up of a freshmen group counseling program.


Innovations at university mental health services.


The traditional role of a psychiatric consultant in a nontraditional college.


A college mental health program that works.


Evaluating utilization and outcome in a small college mental health service: implications for future planning.


Status and use of codes and regulations on campus.


"On catching a clean urine".

"On catching a clean urine".


The University of Kentucky's experience with a voluntary health fee.


A comparison of frequent and non-frequent health service users.


Attitudes and the utilization of health services.


Consumer acceptance of Yale Health Plan.


The use of problem oriented medical records in college health services.


Chromosome patterns of nontransformed variants from chemically transformed Balb-3T3 cells.


Differences in the subcellular localization of the stimulatory effects of glucose and pyruvate on protein synthesis in rat thymus cells in vitro.


Effect of PCMBS on water transfer across biological membranes.


Symposium: new data for noise standards. I. New data for noise standards.


Symposium: new data for noise standards. 3. Organ culture of the mammalian inner ear: a tool to study inner ear deafness.


Symposium: new data for noise standards. II. Effects of insulin on glucose concentrations in inner ear fluids and cochlear microphonics.


Symposium: new data for noise standards. IV. The physiological effects of priming for audiogenic seizures in mice.


Symposium: new data for noise standards. V. Current status of labyrinthine cryosurgery.


Cochlear otosclerosis: fact or fantasy.

Cochlear otosclerosis: fact or fantasy.


Conservative tympanomastoidectomy.

Conservative tympanomastoidectomy.


Orbital complications of sinus diseases.


Benign osteoblastoma of the temporal bone.


Nasopharyngoscopic observations in the Alaskan native.


Mastoid ecchymosis. Battle's sign of basal skull fracture.


X-linked choroidal sclerosis. A stage of choroideremia.


Controlled roentgen examination of the small bowel.


Problems in pathologic fractures.

Problems in pathologic fractures.


Fatal mumps myocarditis.

Fatal mumps myocarditis.


Editorial: Isoniazid toxicity.

Editorial: Isoniazid toxicity.


Editorial: Extractions in hemophilia.

Editorial: Extractions in hemophilia.


Editorial: Pseudotumor cerebri.

Editorial: Pseudotumor cerebri.


Editorial: Mesonephric carcinoma of cervix.


Editorial: Late toxic effects of cytotoxic drugs.


Letter: Extractions in hemophilia.

Letter: Extractions in hemophilia.


X-ray conference. Chest x-ray after auto accident.


The doctor's image of himself.

The doctor's image of himself.


The use of micropore filters in the adminstration of intravenous fluids.


Family practitioners in Minnesota. Need and distribution.


Continuing medical education.

Continuing medical education.


Orthopedic exhibits.

Orthopedic exhibits.


Prediction of clinical coronary heart disease by a test for the coronary-prone behavior pattern.


The leukocyte count as a predictor of myocardial infarction.


Legal abortion: the continuing battle.

Legal abortion: the continuing battle. This article surveys recent legislative proposals and court decisions pertaining to abortion.  The Health Programs Extension Act of 1973, which is now in force, declares that receipt of federal funds does not authorize a court to force a hospital to perform abortions against the religious or moral convictions of the institution.  Included in the act is a provision preventing federally supported hospitals from descriminating against doctors and other staff members who refuse to engage in abortion or sterilization procedures.  The first part of this act was upheld in a federal court in Idaho (Watkins vs. Mercy Medical Center) in a case in which a doctor was denied reappointment to the medical staff of a Catholic hospital because of his refusal to abide by the Code  of Ethics for Catholic Hospitals, which forbids both abortion and sterilizations.  Legislation now pending before Congress can also be described as anti-abortion.  The Legal Services Corporation bill contains a provision barring Legal Services attorneys from representing clients in abortion litigation.  An amendment to the Medicaid Law prevents federal benefits for abortions.  An amendment attached to a bill on medical experimentation would prohibit experimentation on live fetuses.  Furthermore, Representative Hogan and Senator Helms have entered into both houses a constitutional amendment designed to protect the fetus "from the moment of conception."


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 22-1974.


Editorial: Prediction and prognostication in coronary heart disease.


Editorial: "Acanthocytogenesis"--or how the red cell won its spurs.


Letter: Treatment of anaerobic infections.


Letter: Coagulopathy with cefazolin in uremia.


Letter: Maintenance hemodialysis and cardiovascular disorders.


Letter: Measurement of plasma quinidine.


Letter: Influenza B and prevention of Reye's syndrome.


Letter: Possible adverse effect of prednisone in SSPE.


Letter: Leukocyte superoxide in chronic granulomatous disease.


Letter: HB Ag Y-subtypes in Iran.

Letter: HB Ag Y-subtypes in Iran.


Letter: Timing of cholestyramine doses in cholestatic liver disease.


Letter: Hodgkin's disease as an occupational disease of schoolteachers.


Letter: Parathyroid hormone secretion in X-linked hypophosphatemia.


Antibody to hepatitis B core antigen. A sensitive indicator of hepatitis B virus replication.


Viral hepatitis, type B, DNA polymerase activity and antibody to hepatitis B core antigen.


Acute gouty arthritis and response to colchicine in the virtual absence of synovial-fluid leukocytes.


Editorial: New tests for hepatitis B virus.


Editorial: NHI: deductibles and co-insurance.


Editorial: Rubella immunization: a five-year progress report.


Sounding board. Health-care lessons from international experience.


Letter: Elimination of quinidine in congestive heart failure.


Letter: Pulmonary problems after myocardial infarction.


Letter: Stapling of the inferior vena cava.


Letter: Renal biopsy: oversophistication.


Letter: Ratio of renal clearance of amylase and creatinine in pancreatitis (cont.).


Letter: Bone-marrow responses in polycythemia vera.


Letter: Tinel sign in carpal-tunnel syndrome.


Letter: Protection against superoxide anion.


Letter: Problems of human experimentation with new drugs.


Letter: Aids to genetic counseling.

Letter: Aids to genetic counseling.


Letter: MD's as doctors and politicians.


Letter: Questions about recertification.


Letter: Training of the surgical resident.


Nutrition canada--a national nutrition survey.


Endogenous nitrogen excretion in man and the utilization of egg protein.


Equality of inspired and expired N2 in man.


Dental caries prevalence and trace elements other than fluoride.


Forms of bound niacin in wheat.

Forms of bound niacin in wheat.


Phthalates in food.

Phthalates in food.


Editorial: Anticancer behavior.

Editorial: Anticancer behavior.


Editorial: Some ambiguities concerning vitamins in medical practice.


Editorial: Early diagnosis of cancer.

Editorial: Early diagnosis of cancer.


Editorial: Medicine and diplomacy.

Editorial: Medicine and diplomacy.


An evaluation of the utilization and impact of the reports of the Inter-Society Commission for Heart Diseases Resources.


Multiple risk factor reduction in the prevention of cardiovascular disease.


Bacteriuria screening in a disease detection program for healthy females.


Childhood injuries associated with consumer products.


Social and health related characteristics of women using oral contraceptives.


The role of alcohol and tobacco in multiple primary cancers of the upper digestive system, larynx and lung: a prospective study.


Questions and answers: "terpenes" in tobacco.


The influence of ouabain on in vitro renin secretion.


Genetic alteration in a temperature-sensitive mutant of respiratory syncytial virus after replication in vivo.


Autoradiographic localization of RNA synthesis directed by arboviruses in the cytoplasm of infected BHK-21 cells.


Preparation of peroxisomes from mouse liver by rate-zonal centrifugation.


Lymphoid cell dependence of eosinophil response to antigen. IV. Effects of in vitro x-irradiation on adoptive transfer of anamnestic cellular and humoral responses.


Radiolabeled toxin for studying binding of cholera toxin and toxoids to intestinal mucosal receptor sites.


Effect of age on testis delta5-3beta-hydroxysteroid dehydrogenase in the rat.


Absorption and secretion in the rabbit duodenum and ileum.


Electrolyte transport across the mouse small intestine.


Tricarboxylic acid cycle intermediates in muscular dystrophic mice (strain 129).


Mechanism of eosinophilia. X. Evidence for immunologic specificity of the stimulus.


Inhibition of prolactin secretion by cholinergic drug.


Chymopapain C, an immunosuppressive protease. I. Partial purification and characterization.


Influence of prostaglandins E1 and F2a on pulmonary vascular resistance in the sheep.


Studies on lymphocytes. XI. Differences in the lymphocytopoietic activity of peripheral lymphoid organs.


Studies of rhodium(II) carboxylates as potential antitumor agents.


Circadian variation in reticulocyte counts and immuno-detectable erythropoietin titers.


Assessment of atherosclerosis from angiographic images.


Effect of amiloride, furosemide, and ethacrynic acid on Na transport in the rat kidney.


Histologic study of gastric lesions in food-restricted rats.


Comparative incorporation of P32 into lung phosphatidyl choline in mammals with different metabolic and pulmonary morphologic characteristics.


Changes in plasma enzyme activity elicited by running exercise in the dog.


Interaction between acetylcholine and sotalol (MJ-1999) in adrenal medulla.


A humoral suppressor of in vitro lymphocyte transformation responses in cattle with Johne's disease.


Storage iron kinetics. IV. Cellular distribution of ferritin iron stores in rat liver.


Distribution of high-energy phosphates in the heart.


Enhanced binding of 3,5,3'-L-triiodothyronine by rat kidney microsomes after acclimation to cold.


Time course and mechanisms of the acute effects of hypokalemia and hyperkalemia on vascular resistance.


A comparison of the effects of cocaine in arterial and venous smooth muscle responses to vasoactive stimuli.


The effect of hypokalaemia and of digoxin therapy on red cell sodium and potassium content. Some clinical aspects.


Editorial: Phosphatase isoenzymes in human serum.


Occupational risks in Danish clinical chemical laboratories. I.


Occupational risks in Danish clinical chemical laboratories. II. Infections.


Skin blood pressure in hypertensive subjects measured by photoelectric technique.


Metabolism and transcapillary escape rate of albumin in acromegaly.


The effect of noradrenaline and of increased sympathetic activity on the hyperemia following short and prolonged forearm work.


Liver and muscle glycogen in man after glucose and fructose infusion.


Phosphagen and carbohydrate metabolism during exercise in trained middle-aged men.


Influence of age on the local circulatory adaptation to leg exercise.


Statistical analysis of radiation damage to plant chromosomes in relation to the variability of experimental data.


DNA synthesis outside the replication phase. Report I. Cytogenetic analysis of the action of DNA-synthesis inhibitors on human lymphocytes in vitro as it relates to the functional state of the genome.


Role of genetic and environmental factors in the clinical picture and course of psoriasis--a study on twins.


The significance of changes in the blood serum electrolytes in the detection of heterozygous carriers of Duchenne myopathy.


A study of chromosomes in couples with habitual abortions.


The sex ratio in phenylketonuria.

The sex ratio in phenylketonuria.


Some materials on the genetics of mucoviscidosis.


Effects of N-nitrosoethylurea on the appearance of unstable pigment mutants of Chlamydomonas and Chlorella.


Termination of reduplication in phage lambda.


Possibility of the identification of the fourth and fifth pairs of chromosomes of man on the basis of secondary constrictions caused by 5-bromodeoxyuridine.


Transient kwaskiorkor: A cause of fatty liver following small bowel bypass.


Physiologic factors in the selection of patients for superficial temporal artery-to-middle cerebral artery anastomosis.


Pulmonary changes due to hemorrhagic shock resuscitation with isotonic and hypertonic saline.


Are there educational advantages to a surgical clerkship in a university hospital?


Objectives and methods in undergraduate surgical education.


Microcrystalline collagen as a topical hemostatic agent for vascular surgery.


Emerging concepts in the control of surgical infections.


The breast cancer controversy.

The breast cancer controversy.


The effects of the design of housing on the behavior and attitudes of residents.


Commercial opportunities in United States health care in the 1970s.


Self-help treatment programs.

Self-help treatment programs.


The evolutionary mechanisms of neurotic behavior.


Studies of EN-1639A (naltrexone): a new narcotic antagonist.


Mistreatment of patients' families by psychiatrists.


Results of the 1972 APA Self-Assessment Program.


Breaking the bonds of tradition: a reassessment of group treatment of latency-age children.


Human resources: a new approach to the dilemmas of community psychiatry.


A system of neglect: Indian boarding schools.


Manic-depressive illness and acute schizophrenia: a clinical, family history, and treatment-response study.


Cross-cultural evaluation of Schneider's first-rank symptoms of schizophrenia: a report from the International Pilot Study of Schizophrenia.


Major and minor criteria in schizophrenia.


Phenylethylamine hypothesis of affective behavior.


Thought disorder in depression.

Thought disorder in depression.


Letter: The psychiatric establishment and social change.


Letter: Psychiatrists and political torture.


Letter: Drug abuse as a coping mechanism.


Letter: Cyclandelate and improved brain function.


Letter: The adult hyperkinetic.

Letter: The adult hyperkinetic.


Letter: Salaried versus volunteer faculty in psychiatric education.


Role of trigeminal, olfactory, carotid sinus and aortic nerves in the respiratory and circulatory response to nasal inhalation of cigarette smoke and other irritants in the rabbit.


Autonomic cardiovascular effects of nasal inhalation of cigarette smoke in the rabbit.


Ovine proinsulin--identification and immunological similarity to bovine proinsulin.


The lysosomal enzymes acid phosphatase and beta-glucuronidase in muscle following a period of ischaemia.


Protein patterns in normal and induced pathological salivary glands of mice.


Effect of castration on cholesterol metabolism and hepatic cytochrome P-450 in piperazine-treated male and female rabbits.


Histochemical analysis of the diffusion of noradrenaline across the artery wall.


The influence of replacing sodium by potassium ions on uptake of noradrenaline in the rabbit ear artery.


Water and electrolyte excretion in the cat submaxillary gland studied using micropuncture and duct cannulation techniques.


Quantitative studies on the response of normal and leukaemic lymphocytes to phytohaemagglutinin.


On the inhibitory power of some further pyrazole derivatives of horse liver alcohol dehydrogenase.


Circular dichroism of C5a anaphylatoxin of porcine complement.


The binding of barium and calcium ions by the antibiotic beauvericin.


Molecular form of adenosine deaminase in severe combined immunodeficiency.


The magnitude of enzyme transition state analog binding constants.


Conformation of N-(purin-6ylcarbamoyl) glycine, a hypermodified base in tRNA.


Binding of imidazole and 2-methylimidazole by hemes in organic solvents. Evidence for five-coordination.


Enzymatic transfer of the acyl group from acyl dihydroyxacetone phosphate to different substrates.


Degradation of chromosomal proteins during dissociation and reconstitution of chromatin.


Evidence for the glycoprotein nature of the inducer of sexuality in Volvox.


Mechanical stability of hemoglobin subunits: an abnormality in betaS-subunits of sickle hemoglobin.


Inhibition of DNA synthesis by isolated liver nuclei from frog virus 3 infected mice.


Resonance Raman spectra of chymotrypsin acyl enzymes.


Structure-function relationship in the 12,13-epoxytrichothecenes. Novel inhibitors of protein synthesis.


Aggregates of partially purified mRNA coding for immunoglobulin light-chain.


Activation of the action of penicillopepsin on leucyl-tyrosyl-amide by a non-substrate peptide and evidence for a conformational change associated with a secondary binding site.


The application of nanosecond fluorometry to an allosteric protein.


"Orbital steering", entropy, and rate accelerations.


Formation of free acetate by isolated perfused livers from normal, starved and diabetic rats.


The binding of long chain fatty acid CoA to Z, a cytoplasmic protein present in liver and other tissues of the rat.


Fluorescent Ca+2 analogs in nerve: rare-earth ions.


The specificity of glycine-N-acylase and acylglycine excretion in the organicacidaemias.


Fluorescence of blood protoporphyrin in the presence of hemoglobin.


A method for the concentration of erythropoietin from human urine.


Separation of glucose from physiological fluids for radioactive counting. Ion exchange resin thin layer chromatography.


An improved method for direct, rapid extraction of bile for morphine.


Nuclear metabolism. 3. Permeability of isolated calf thymus nuclei.


Studies on brain guanidino compounds by automatic liquid chromatography.


Evidence for a single kind of D-glucose binding site on renal brush borders.


Analysis of factors influencing the in vitro developmental pattern of p-aminohippurate transport by rabbit kidney.


Anomalous transport kinetics and the glucose carrier hypothesis.


The movement of monocarboxylic acids across phospholipid membranes: evidence for an exchange diffusion between pyruvate and other monocarboxylate ions.


Further observations on the interaction of prostaglandin F2 alpha with cholinergic mechanisms in canine salivary glands.


Features of the choleretic action of caerulein.


The effects of lithium on excitable cell membranes. On the mechanism of inhibition of the sodium pump of non-myelinated nerve fibres of the rat.


Development of tolerance to the stimulatory effect of morphine in dog intestine.


Carbidopa attenuation of L-DOPA emesis in dogs: evidence for a cerebral site of action outside the blood-brain barrier.


Increased juxtamedullary blood flow on stimulation of intrarenal prostaglandin biosynthesis.


The effect of LB-46, a beta-adrenoreceptor blocking drug, on isolated normal and ouabain-intoxicated Purkinje fibers of the dog.


Dopamine uptake in striatal and hypothalamic synaptosomes: conformational selectivity of the inhibition.


The effect of catecholamines and ATP on the smooth muscle cell membrane of the guinea-pig taenia coli.


Measurement of gastric acid secretion by conductivity.


The effect of morphine on pituitary-thyroid function in the rat.


The effect of long-term oral treatment of rats with contraceptive steroids on tissue MAO.


Thalamic organization of the retino-thalamo-hyperstriatal pathway in the pigeon (Columba livia).


The orientation selectivity of single neurons in cat striate cortex.


Ribosomal RNA in mouse spermatocytes.

Ribosomal RNA in mouse spermatocytes.


Intrinsic factors influencing the maintenance of contractile embryonic heart cells in vitro. I. The heart muscle conditioned medium effect.


RNA transcription in mature sea urchin eggs.


Studies on the interaction between mitogens and human lymphocytes in vitro.


Intrinsic factors influencing the maintenance of contractile embryonic heart cells in vitro. II. Biochemical analysis of heart muscle conditioned medium.


Early mouse embryos: growth and differentiation in vitro.


A comparative study of in situ hybridization procedures using cRNA applied to Drosophila hydei salivary gland chromosomes.


Kinetics of lymphocyte stimulation in vitro by non-specific mitogens.


A quantitative estimation of the association of mitochondria to septate desmosomes in the sea urchin larva.


Pore patterns on nuclear membranes.

Pore patterns on nuclear membranes.


Editorial: Car seat belts.

Editorial: Car seat belts.


An unusual seat belt injury.

An unusual seat belt injury.


Irreducible traumatic posterior dislocation of the hip.


Central dislocation of the hip causing mechanical intestinal obstruction.


The significance of good reduction and fixation in displaced subcapital fractures of the femur.


Closed treatment of fracture of the tibial spines.


The Dr. Eric Gardner award to ambulancemen.


Traumatic tension ischaemia in muscles.

Traumatic tension ischaemia in muscles.


The role of the hospital in disasters.

The role of the hospital in disasters.


Rupture of muscles by traction.

Rupture of muscles by traction.


Small gut injuries in blunt abdominal trauma: 18 cases from Uganda.


Retransfusion acidosis after haemorrhagic hypotension in dogs.


Bilateral fracture of the first rib with bilateral pneumothorax.


New retractor for bone surgery: locking bone levers.


Phlebography for fracture of the femoral neck in adolescence.


Supracondylar fractures of the femur in the elderly: treatment by internal fixation.


Intracranial volume pressure studies in patients with head injury.


Letter: Acrylic bone cements.

Letter: Acrylic bone cements.


On the management of lingual carcinoma.

On the management of lingual carcinoma.


Recent advances in biomicroscopy of the fundus.


The Center for Visual Science, University of Rochester.


The problems of asthma.

The problems of asthma.


Surgery in corticosteroid-dependent asthmatics.


Biochemical and ultrastructural aspects of Ca2+ transport by mitochondria of the hepatopancreas of the blue crab Callinectes sapidus. Mitochondria isolated from the hepatopancreas of the blue crab Callinectes sapidus show up to 12-fold stimulation of respiration on addition of Ca(2+), which is accompanied by Ca(2+) accumulation (Ca(2+):site = 1.9) and H(+) ejection (H(+):Ca(2+) = 0.85). Sr(2+) and Mn(2+) are also accumulated; Mg(2+) is not. A strongly hypertonic medium (383 mosM), Mg(2+), and phosphate are required for maximal Ca(2+) uptake. Ca(2+) uptake takes precedence over oxidative phosphorylation of ADP for respiratory energy. Once Ca(2+) is accumulated by the crab mitochondria, it is stable and only very slowly released, even by uncoupling agents. ATP hydrolysis also supports Ca(2+) uptake. Respiration-inhibited crab hepatopancreas mitochondria show both high-affinity and low-affinity Ca(2+)-binding sites, which are inactive in the presence of uncoupling agents. Crab hepatopancreas mitochondria have an enormous capacity for accumulation of Ca(2+), up to 5,500 ng-atoms Ca(2+) per mg protein, with an equivalent amount of phosphate. Freshly isolated mitochondria contain very large amounts of Ca(2+), Mg(2+), phosphate, K(+), and Na(+); their high Ca(2+) content is a reflection of the vary large amount of extra-mitochondrial Ca(2+) in the whole tissue. Electron microscopy of crab mitochondria loaded with Ca(2+) and phosphate showed large electron-dense deposits, presumably of precipitated calcium phosphate. They consisted of bundles of needle-like crystals, whereas Ca(2+)-loaded rat liver mitochondria show only amorphous deposits of calcium phosphate under similar conditions. The very pronounced capacity of crab hepatopancreas mitochondria for transport of Ca(2+) appears to be adapted to a role in the storage and release of Ca(2+) during the molting cycle of this crustacean.


Calcium phosphate granules in the hepatopancreas of the blue crab Callinectes sapidus. The hepatopancreas of the adult male blue crab Callinectes sapidus in intermolt was found to contain substantial amounts of calcium, magnesium, and inorganic phosphorus, averaging about 260, 20, and 250 microg-atoms per g wet tissue, respectively, accounting for over 10% of the tissue dry weight. Electron microscopy of the intact tissue showed three qualitatively different granular structures having electron densities suggestive of high mineral content. After fractionation of the tissue using centrifugal techniques, almost 95% of the total mineral was found to reside in a heavy, nonmitochondrial particulate fraction(s). The bulk of the low-speed pellet consisted of relatively dense, roughly spherical granules 1-5 microm in diameter, which could be considerably purified by repeated suspension in water and low-speed sedimentation. In the electron microscope the isolated granules appeared basically similar to one of the three characteristic types of electron-dense granules seen in the intact tissue. Although the freshly isolated granules lost approximately 50% of their wet weight when dried at 105 degrees C, only 10% more was lost upon dry ashing at 450 degrees C, suggesting a fairly low content of organic material. Chemical analysis revealed calcium, magnesium, and inorganic phosphate at 5.7, 2.1, and 4.4 microg-atoms per mg dried granules, respectively, accounting for 69% of the dry weight of the fraction. By specific enzymatic assays, the freshly isolated granules were found to contain ATP, ADP, and AMP at levels of 0.13, 0.03, and 0.01 micromol/mg, or 8% of their total dry weight. The remainder of the total phosphorus contributed an additional 3%, whereas carbonate, citrate, oxalate, and protein each constituted no more than 1%. The mineral granules of the crab hepatopancreas appear to function as storage forms of calcium and phosphate during the intermolt period. This tissue appears promising as a model for study of the cellular events associated with biological calcification, since conventional biochemical techniques can be employed. Furthermore, the major mineralized component of the tissue can be obtained in large amounts for direct study by a simple fractionation procedure.


Renewal of fatty acids in the membranes of visual cell outer segments. The renewal of fatty acids in the visual cells and pigment epithelium of the frog retina was studied by autoradiographic analysis of animals injected with tritiated palmitic, stearic, or arachidonic acids. Most of the radioactive material could be extracted from the retina with chloroform-methanol, indicating that the fatty acids had been esterified in lipids. Analysis of the extracts, after injection of [(3)H]palmitic acid, revealed that the radioactivity was predominantly in phospholipid. Palmitic acid was initially concentrated in the pigment epithelium, particularly in oil droplets which are storage sites for vitamin A esterified with fatty acid. The cytoplasm, but not the nucleus of these cells, was also heavily labeled. Radioactive fatty acid was bound immediately to the visual cell outer segment membranes, including detached rod membranes which had been phagocytized by the pigment epithelium. This is believed to be due to fatty acid exchange in phospholipid molecules already situated in the membranes. Gradually, the concentration of radioactive material in the visual cell outer segment membranes increased, apparently as a result of the addition of new phospholipid molecules, possibly augmented by the transfer from the pigment epithelium of esterified vitamin A. Injected fatty acid became particularly concentrated in new membranes which are continually assembled at the base of rod outer segments. This localized concentration was short-lived, apparently due to the rapid renewal of fatty acid. The results support the conclusion that rods renew the lipids of their outer segments by membrane replacement, whereas both rods and cones renew the membrane lipids by molecular replacement, including fatty acid exchange and replacement of phospholipid molecules in existing membranes.


Ecdysone-mediated stimulation of DOPA decarboxylase activity and its relationship to ovarian development in Aedes aegypti. Very little dopa decarboxylase activity is detectable in adult female mosquitoes Aedes aegypti which have not been allowed to engorge blood. However, when such females are injected with the molting hormone beta-ecdysone a marked stimulation of this enzyme's activity is observable. No stimulation is observed in males similarly injected, nor in females injected with cholesterol or a juvenile hormone mimic. In addition, ecdysone injection initiates ovarian development in these anautogenous non-blood-fed mosquitoes. The extent of stimulation in both cases is dependent upon the amount of beta-ecdysone administered. These results suggested that ecdysone may play a role in ovarian development in Aedes and led us to hypothesize that a normal blood meal may trigger the synthesis, activation, or release of this hormone endogenously. Using the radioimmune assay for ecdysone developed by Borst and O'Connor (Science [Wash. D. C.] 178:4-18.), we found that the titer of an antigenic-positive material, presumably ecdysone or a closely related analogue, substantially increased 24 h after blood feeding, thereby supporting our postulation.


Freeze fracture of skeletal muscle from the Tarantula spider. Structural differentiations of sarcoplasmic reticulum and transverse tubular system membranes. The structure of the membranes of sarcoplasmic reticulum (SR), tubular (T) system, and sarcolemma has been studied by freeze fracture in leg muscles of the Tarantula spider. Two regions of the sarcoplasmic reticulum can be differentiated by the distribution of particles on the fracture faces: a junctional SR, at the dyads, and a longitudinal SR, elsewhere. The dyads are asymmetric junctions, the disposition of particles in the apposed membranes of SR and T tubules being different from one another and from the regular arrangement of feet in the junctional gap. It is concluded that no channels can be visualized to directly connect SR- and T-system lumina.


Metabolism of isolated fat cells from various tissue sites in the rat: influence of hemorrhagic hypotension. The in vitro lipolytic response to norepinephrine by rat adipocytes from epididymal, subcutaneous, perirenal, mesenteric, and omental tissue sites was studied in control and hypotensive animals. Lipolysis per millimole of triglyceride was found to be three to four times higher in mesenteric and omental fat cells than in adipocytes of the other sites sampled. The high lipolytic activity of mesenteric and omental adipocytes was partly attributable to their smaller cell size; however, lipolysis per cell was also higher. Hemorrhagic hypotension caused a 50-60% decrease in lipolytic activity at four of the five sites studied. Adipocytes of omental origin maintained their lipolytic activity at the prehypotensive level, however, indicating that the metabolic adjustments brought about by hemorrhagic hypotension are not uniform at all adipose tissue sites.


Production of plasma esterified cholesterol in lean, normotriglyceridemic humans. The rate of production of plasma esterified cholesterol was measured both in vivo and in vitro in seven subjects and in vivo alone in eight subjects. All subjects were lean, clinically healthy, and had triglyceride concentrations less than 1.5 micro moles/ml. In vivo production was calculated from the labeling of free and esterified cholesterol in plasma samples collected at 1-hr intervals for 8 hr after an intravenous injection of [(3)H]mevalonic acid, on the assumption that plasma free cholesterol was the sole immediate precursor of esterified cholesterol. In vitro production was measured in serum samples collected 1 hr after the injection of [(3)H]mevalonic acid (when radioactivity in esterified cholesterol was very low relative to that in free cholesterol); these samples were incubated for 1 hr at 37 degrees C. The rates measured in vivo and in vitro were very similar in the seven subjects, strengthening the confidence in the techniques. In vivo production was measured during the postabsorptive state in all 15 subjects and in 5 of them also during the last 8 hr of a 32-56-hr period when all calories were taken in three hourly meals of an 80% carbohydrate, fat-free formula. In the postabsorptive state there was no apparent relationship between the production of esterified cholesterol and the concentration of either free or esterified cholesterol. Rather, despite a wide range of cholesterol concentrations, esterified cholesterol production was similar in all subjects. During the carbohydrate consumption the esterified cholesterol concentrations were significantly lower than during the postabsorptive state, but there was virtually no change in rate of production. It has been concluded that the differences in concentration of esterified cholesterol in lean, normotriglyceridemic subjects cannot be explained solely on the basis of differences in its production.


Microtubule biogenesis and cell shape in Ochromonas. 3. Effects of herbicidal mitotic inhibitor isopropyl N-phenylcarbamate on shape and flagellum regeneration. The role of microtubules and microtubule nucleating sites in the unicell, Ochromonas has been examined through the use of two mitotic inhibitors, isopropyl N-phenylcarbamate (IPC) and isopropyl N-3-chlorophenyl carbamate (CIPC). Although IPC and CIPC have little or no effect on intact microtubules, the assembly of three separate sets of microtubules in Ochromonas has been found to be differentially affected by IPC and CIPC. The assembly of flagellar microtubules after mechanical deflagellation is partially inhibited; the reassembly of rhizoplast microtubules after pressure depolymerization is totally inhibited (however, macrotubules may form at the sites of microtubule initiation or elsewhere); and, the reassembly of the beak set of microtubules after pressure depolymerization may be unaffected although similar concentrations of IPC and CICP completely inhibit microtubule regeneration on the rhizoplast. These effects on microtubule assembly, either inhibitory or macrotubule inducing, are fully reversible. The kinetics of inhibition and reversal are found to be generally similar for both flagellar and cell shape regeneration. Incorporation data suggest that neither IPC nor CIPC has significant effects on protein synthesis in short term experiments. Conversely, inhibiting protein synthesis with cycloheximide has little effect on microtubule regeneration when IPC or CIPC is removed. Although the exact target for IPC and CIPC action remains uncertain, the available evidence suggests that the microtubule protein pool or the microtubule nucleating sites are specifically and reversibly affected. Comparative experiments using the mitotic inhibitor colchicine indicate some similarities and differences in its mode of action with respect to that of IPC and CIPC on assembly and disassembly of microtubules in these cells.


Chemical composition of uropygial gland secretions of owls. The compositions of the uropygial gland secretions of the long-eared owl, eagle owl, and barn owl have been determined. The waxes of the first two owls, which are closely related, are composed of 2-alkyl-substituted fatty acids and n- or monomethyl-branched alcohols with even-numbered branching positions. In addition, some dimethyl-substituted alkanols were observed. In contrast to these waxes, the secretion of the barn owl is composed of 3-methyl- and 3,5-, 3,7-, 3,9-, 3,11-, 3,13-, and 3,15-dimethyl-branched fatty acids and n- as well as monomethyl-substituted alkanols branched at positions 2, 3, and 4. The mass spectra of esters of 2-alkyl-substituted fatty acids are discussed.


Transformation of 5 alpha-cholest-7-en-3 beta-ol to cholesterol and cholestanol in cerebrotendinous xanthomatosis. The metabolism of Delta(7)-cholestenol, cholesterol, and cholestanol was examined in a patient with cerebrotendinous xanthomatosis after intravenous pulse-labeling with a mixture of dl-[2-(14)C]mevalonate and stereospecific 3S,4S,3R,4R-[4-(3)H]mevalonate. Silver nitrate and reversed-phase thin-layer chromatography were used to purify the sterols isolated from the feces, and their identities were confirmed by gas-liquid chromatography-mass spectrometry. The specific activities were determined and plotted as a function of time. Isotope ratio measurements and specific activity decay curves showed that sterol synthesis proceeded in the following sequence: mevalonate, squalene, lanosterol, Delta(7)-cholestenol, cholesterol, cholestanol. Labeled cholesterol precursors might be advantageously used to measure changes in cholesterol synthesis because they appear to equilibrate rapidly and have very short turnover times.


Effects of cold exposure on heart clearing factor lipase and triglyceride utilization in the rat. The clearing factor lipase activity of the rat heart was measured in animals kept at 4 degrees C for several hours and was compared with that in control animals kept at 25 degrees C. The total activity of the enzyme in the heart increased markedly on exposure to the low temperature, whether the animals were in a fed or a fasted state. The activities of both the heparin-releasable and the heparin-nonreleasable enzyme fractions were usually raised. However, only increases in the former could be correlated satisfactorily with corresponding increases in the capacity of the heart to utilize chylomicron triglyceride fatty acids perfused through it. Cold exposure also raised the plasma clearing factor lipase activity and reduced the plasma triglyceride concentration. These changes may have been due, at least in part, to the alterations in the activity of the tissue enzyme.


A lipid-soluble antioxidant from polyallomer centrifuge tubes. Santowhite, a commercial antioxidant used in the manufacture of polypropylene, contaminates 12-ml polyallomer tubes to the extent of 0.2-0.3 mg/tube. It is distributed through the plastic and appears as a microscopic dust on the tubes' surfaces. In the preparation of polysomes from rat liver by standard methods, approximately 15% of the antioxidant in previously water-washed tubes was removed by suspension of the polysome pellet with stirring in 1-2 ml of Tris buffer, pH 7.8. The polyallomer impurity has been shown to be identical with Santowhite, which is 4,4'-butylidene-bis(6-tert-butyl-m-cresol), by UV, mass, and NMR spectra. It is not uniformly removed from polyallomer tubes by common detergents but is removed by washing with acetone, to which the plastic is resistant.


Quantitative analysis of cholesterol in 5 to 20 microliter of plasma. A gas-liquid chromatographic micromethod for quantitation of cholesterol in 20 micro l of plasma was developed using 5alpha-cholestane as an internal standard, saponification with tetramethylammonium hydroxide-isopropanol, and extraction with tetrachloroethylene-methyl butyrate. Cholesterol levels in plasma samples were calculated by comparing cholesterol-cholestane peak height ratios with those of preassayed reference plasma. Over a plasma cholesterol range of 44 to 468 mg/100 ml, the gas-liquid chromatographic micromethod and the automated ferric chloride colorimetric method gave nearly identical results (r = 0.99) in duplicate aliquots of 131 plasma samples.


Clinical appraisal of pateints with abdominal and thoraco-abdominal trauma.


The incidence of diabetes mellitus in patients with tinea versicolor.


Fibro-osseous lesions of the jaw in Nigeria.


Head injuries. Review of 150 cases.

Head injuries. Review of 150 cases.


Principles of ultrasonography.

Principles of ultrasonography.


Hip pain and its variants: radiological aspects.


Lipomelanotic choristoma. A case report.


Psychotropic drugs--harm or help.

Psychotropic drugs--harm or help.


Plasmacytoma.

Plasmacytoma.


Health manpower.

Health manpower.


Blacks and the urban health crisis.

Blacks and the urban health crisis.


Demographic findings and health care. A model for student physicians.


Economic policy: who pays, who gets what? The neighborhood health center viewpoint.


Hospitals continue to grow despite federal cutbacks.


A profile of adolescents in a family planning center.


Roentgenogram of the month. Fibrous cortical defect.


Changes in pulmonary capillary filtration and ventilatory dead space during exposure to 95 per cent oxygen.


Pulmonary contusion and hemorrhage--crystalloid versus colloid replacement.


The adequacy of the cerebral collateral circulation: tolerance of awake experimental animals to acute bilateral common carotid artery occlusion.


Plasma amino acids in dogs with two experimental forms of liver damage.


The effect of vagotomy on resting and stimulated serum gastrin levels.


Augmented acid and gastrin response to meals after pancreatic duct ligation.


Studies on isoenzymes of human amylase: evidence for a circulating amylase not of pancreatic or salivary origin.


Plasma and thoracic duct albumin kinetics during hemorrhage treated with lactated Ringer's solution.


Early alterations in mitochondrial membrane transport during endotoxemia.


The demonstration of energy dependence of the isoproterenol-induced transcellular Ca2+ current in isolated perfused guinea pig hearts--an explanation for mechanical failure of ischemic myocardium.


Ischemic damage to nuclei is not altered by steroids.


The distal esophageal sphincter and its relationship to gastroesophageal reflux.


Quantitative radioimmunoassay of immunoglobulins on the surface of human tumor cells.


Comparative studies of "state of the art" and presently used clinical cardiac pacemaker electrodes.


A physiological approach to high-frequency testing of prosthetic ball valves.


Chronic hemolysis produced by cloth-covered valves. The effect of design and valve position.


Electrophysiological delineation of the specialized atrioventricular conduction system in patients with congenital heart disease. I. Delineation of the His bundle proximal to the membranous septum.


The pacemaker twiddler's syndrome. A further note.


Role of serotonin and serotonin antagonist on pulmonary hemodynamics and microcirculation in hemorrhagic shock.


Left ventricular aneurysmectomy in a 4-month-old infant. Alternative method of treatment of anomalous left coronary artery.


Early and late complications of single mitral valve replacement. A comparison of eight different prostheses.


Albumin and water fluxes during cardiopulmonary bypass.


Cerebral hypotension and shock lung syndrome.


Graham Traveling Fellowship.

Graham Traveling Fellowship.


Stenosis of individual pulmonary veins. Review of the literature and report of a surgical case.


In defense of long-term psychotherapy.

In defense of long-term psychotherapy.


Rheumatic fever in Florida.

Rheumatic fever in Florida.


DWD legislation. It really isn't necessary.


Death with dignity. A legislative necessity.


Continuing education for the physicians of Florida.


Editorial: First, do no harm.

Editorial: First, do no harm.


Florida's immunization law.

Florida's immunization law.


Editorial: Rheumatic fever remains a health problem.


Histomorphology of the ultimobranchial gland in Heteropneustes fossilis Bloch.


Novel occurrence of 5 beta-cholanic acid in plants: isolation from jequirity bean seeds (Abrus precatorius L.).


Use of subcutaneous silastic implants for the study of 11 beta, 17 alpha, 21-trihydroxy-4-pregnene-3,20-dione(cortisol) metabolism.


A competitive radioligand assay for danazol (17 alpha-pregn-4-en-20-yno(2,3-d)isoxazol-17-ol) using pregnant guinea pig plasma.


Variations in the excretion patterns of some metabolites of cortisol as affecting measurement of its secretion rate.


East Asia Review, 1973. 2. Indonesia.

East Asia Review, 1973. 2. Indonesia.


The quantitative measurement of steroids secreted by isolated adrenals from sodium depleted rats.


East Asia Review, 1973. 1. Hong Kong.

East Asia Review, 1973. 1. Hong Kong. Developments in the field of population and family planning during 1973 in Hong Kong are reviewed.  The most significant event of the year was the start of the government family planning program.  Hong Kong $2.4 million has been allocated to cover the cost of the government's participation in a phased program to integrate family planning services into its maternal and child health program.  4 part-time clinics run by the Family Planning Association of Hong Kong became the responsibility of the Medical and Health Department in October 1973.  In January 1974, 4 full-time clinics will be taken over, and the remaining clinics in maternal and child health centers will be turned over beginning April 1974.  This should 3e completed by the end of 1974.  The crude annual birth rate for 1973 was 19.8 per thousand.  In 1972 it was 19.7.  The death rate remained at around 5.  The population growth rate increased to around 3%, of which about half was due to immigration from China.  There was a 5.8% increase in new acceptors from January 1973 to November 1973.  The Association increased its use of the mass media, particularly radio and television.  In 1972, the Association conducted a "Study of the Impact of Industrialization on Fertility in Hong Kong" in conjunction with the Social Research Center of the Chinese University.  It was determined that industrialization has affected fertility in a number of interrelated ways.  Higher education levels, better employment opportunities (particularly for women), urbanization, desire for improved living standards, and postponement of marriage, which are the primary effects of industrialization, have resulted in changing  attitudes toward children and childbearing as reflected in the finding that the percentage of people using contraceptives rose from 44% in 1967 to 48% in 1972.  In the future, the Association will establish new clinics in those parts of the colony not presently being reached, and it will develop services to reach such groups as working women, men, and "middle-class" clients.  The Association will develop large-scale information, education, and publicity programs.


East Asia Review, 1973. 3. Korea (South).


East Asia Review, 1973. 4. Laos.

East Asia Review, 1973. 4. Laos.