Inhibition of isocitrate lyase from Pseudomonas indigofera by itaconate.


Inhibition of leucocyte migration in patients with large intestinal cancer by extracts prepared from large intestinal tumours and from normal colonic mucosa. The degree of migration inhibition in response to tissue extracts has been examined in leucocyte preparations obtained from patients with large intestinal cancer and from age and sex matched control individuals. A greater degree of migration inhibition was observed in response to a colorectal tumour extract in cells obtained from the cancer patients. Inhibition also tended to be more marked in response to the tumour extract than in response to a normal colonic mucosal extract in these patients. These results suggest that altered cellular immune reactivity is demonstrable by this simple in vitro technique in patients with large intestinal cancer.


Inhibition of norepinephrine uptake by potassium ions in vascular smooth muscle.


Inhibition of papain-induced emphysema in the hamster by human alpha1-antitrypsin.


Inhibition of photosystem II electron transport in chloroplasts by fatty acids and restoration of its activity by Mn2+.


Inhibition of protein synthesis and induction of helical polysomes in rat liver by N-hydroxy-2-fluorenylacetamide.


Inhibition of sickling in vitro by sodium naproxen.


Inhibition of the activity of the testicle exerted by an extract of spermatozoa.


Inhibition of the biosynthesis of isoprenoid compounds by phenolic acids in the rat brain.


Inhibition of thermoregulatory non-shivering thermogenesis by trauma in cold-acclimated rats. 1. Heat production and blood flow in the interscapular brown adipose tissue of 3 degrees C acclimated rats have been measured by the heated thermo-couple technique.2. When the environmental temperature (T(a)) was reduced from 30 to 3 degrees C heat production by the brown adipose tissue began to increase at the lower limit of the thermoneutral zone and then increased linearly.3. Blood flow also increased when T(a) was reduced but was not so well correlated with T(a). There was however a good positive correlation between blood flow and heat production.4. During the first hour after a 4 hr period of bilateral hind-limb ischaemia in a 20 degrees C environment the percentage of rats not producing heat in the interscapular brown adipose tissue increased and the tissue blood flow fell.5. By varying the T(a) of the injured rat it was found that the T(a) at which heat transfer from the interscapular brown adipose tissue commenced was significantly lower than in the controls although the slope of the regression lines relating heat production and T(a) was unaltered.6. Blood flow also increased in the injured rat when T(a) was lowered but the increase in the tissue blood flow per unit increase in heat production was less than in the controls.7. In a 5 degrees C environment heat production in the interscapular brown adipose tissue of the injured rat was further increased by the S. C. injection of L-isoprenaline or L-noradrenaline.8. It is concluded that the central control of thermoregulatory non-shivering thermogenesis is inhibited after injury in the rat.


Inhibitors of haemopoietic cell proliferation: reversibility of action.


Initiation of in vitro RNA synthesis with deoxyribosyl oligomers.


Initiation of globin synthesis: assays.

Initiation of globin synthesis: assays.


Initiation of metamorphosis in laboratory cultured sea urchins.


Inner canthal and intermamillary indices in the newborn infant.


Initiation of the replication of single-stranded DNA by concerted action of phage T7 RNA and DNA polymerases.


Injury to the cervical spine as a cause of headache.


Insect hormones and their bioanalogues as potential insecticides.


Insensitivity of the autotransplanted ovary of the ewe to ovine luteinizing hormone.


Insulin radioimmunoassay: a comparison of three methods.


Insulin resistance in experimental shock.


Interaction of aldolase with the troponin-tropomyosin complex of bovine muscle. Ultracentrifugal studies of mixtures of aldolase and the troponin-tropomyosin complex from bovine muscle showed the existence of a labile interaction between these two myofibrillar constituents in imidazole buffers, pH6.8, I 0.02-0.10 (mol/l), and the suppression of the reaction by fructose 1,6-diphosphate. Analysis of the sedimentation-velocity patterns suggests the binding of more than 2 molecules of troponin-tropomyosin/molecule of aldolase. The results illustrate the necessity of considering additional or alternative sites to F-actin to account for the observed binding of aldolase to the thin filaments of skeletal muscle.


Interaction of beta-amylase with substrates and inhibitors with comments on Koshland's Induced-Fit Theory. A reply.


Interaction of biguanides with mitochondrial and synthetic membranes. Effects on ion conductance of mitochondrial membranes and electrical properties of phospholipid bilayers.


Interaction of catecholamine and amino acid metabolism in brain: effect of pargyline and L-dopa.


Interaction of deoxy and deoxyfluoro-substrate analogs and related compounds with sn-glycerol-3-phosphate dehydrogenase of locust flight muscle mitochondria.


Interaction of sodium warfarin and rifampin. Studies in man.


Interaction of nogalamycin with DNA.

Interaction of nogalamycin with DNA.


Interaction of 8-hydroxyquinoline sulfate with components of tuberculin purified protein derivative solutions. 3. Binding of 8-hydroxyquinoline by tuberculin purified protein derivative.


Interactions leading to horizontal cell responses in the turtle retina. 1. Small responses to large fields of dim monochromatic lights were recorded intracellularly from luminosity horizontal cells (L-cells), chromaticity horizontal cells (C-cells) and cones in the retinae of turtles, Pseudemys scripta elegans.2. Responses of cones to brief flashes applied over steady backgrounds were studied in order to interpret the corresponding responses of horizontal cells. Steady red or green backgrounds make the responses of red-sensitive cones smaller, faster and often diphasic. Green backgrounds have similar effects on the responses of green-sensitive cones to green flashes, but red backgrounds do not change them appreciably. Responses of double cones have properties intermediate between those of red and green cones.3. L-cells of both type I and type II are hyperpolarized by all visible wave-lengths, and their spectral sensitivity in the linear range resembles that of red cones. Their responses are not invariant with respect to colour, and their sensitivity to green relative to red stimuli increases during red backgrounds. These properties suggest that L-cells are activated mainly by red cones but also receive impingement from the red members of double cones.4. Spectral properties of red/green C-cells resemble those of green cones as modified by the recurrent action of L-cells. They can be explained assuming that red/green C-cells receive their principal impingement from green cones and subsidiary interactions from green/blue C-cells and the green members of double comes.5. The spectral sensitivity of the hyperpolarizing responses of green/blue C-cells is ascribed to impingement from blue cones. Their depolarizing responses have complex properties which suggest that they are brought about by the activity of both L-cells (probably through the blue cones) and red/green C-cells.6. It is concluded that the main properties of the responses of the horizontal cells can be explained by a simple circuit in which each horizontal cell is connected to a corresponding type of cone and the L-cells have a recurrent impingement on all cones. The scheme is modified by additional interactions which operate on the responses of each horizontal cell type.


Interactive effects of alpha feedback and instructional set on subjective state.


Insulin antibodies in sera of diabetics under phenothiazine-treatment or with delirium tremens.


Intercellular communication between lymphocytes in vitro. Fluorescein-permeable junctions, their enhancement by lysolecithin and their reduction by a synthetic immunosuppressive lysolecithin analogue.


Interconversion of the different hybrids of aminopeptidase I.


Interference by traces of acetic anhydride in nonaqueous titrimetry of primary aromatic amines: improved titrations for procainamide hydrochloride.


Intermolecular basis of odour.

Intermolecular basis of odour.


Intermittent cyclophosphamide in pemphigus vulgaris and bullous pemphigoid. Cyclophosphamide, given in widely spaced doses, was used in the treatment of a patient with pemphigus vulgaris and a patient with bullous pemphigoid. To our knowledge, this form of therapy has not previously been reported in these two diseases. The distinct advantages of the larger intermittent dose method of cyclophosphamide therapy over the more conventional daily dose regimen are discussed.


Intermolecular forces.

Intermolecular forces.


International collaborative study of dental manpower systems in relation to oral health status.


International efforts in family planning training.


Interphase chromosomal deoxyribonucleoprotein isolated as a discrete structure from cultured cells.


Interpretation in child analysis. Development considerations.


Interrelations between 17 ketosteroids, 17 ketogenic steroids, body weight, and height in normal and obese women.


Interrelationship between phosphoenolpyruvate and citrulline synthesis in guinea pig liver mitochondria.


Interrelationship of parathyroid and adrenocortical function in calcium homeostasis in the rat.


Intervention strategies for infants in day care centers and institutions.


Intestinal absorption of intake antigenic protein.


Intestinal beta-galactosidases in adult low lactase activity and in congenital lactase deficiency.


Intestinal oxalate absorption.

Intestinal oxalate absorption.


Intestinal schistosomiasis north and west of Lake Tana, Ethiopia.


Intestinal transmural electrical properties: effects of conjugated bile salt in vitro.


Internal anal sphincterotomy plus free dilatation versus anal stretch with special criticism of the anal stretch procedure for hemorrhoids: The recommended modern approach to hemorrhoid treatment.


Intra-aortic balloon pumping for mechanical left ventricular assistance.


Interviewing techniques for nurses.

Interviewing techniques for nurses.


Intra-arterial methotrexate chemotherapy and telecobalt therapy in cancer of the oral cavity and oropharynx.


Intracardiac phonocardiography in patients with Ebstein's disease of the heart.


Intra-epithelial carcinoma of the vagina following immunosuppression treated with topical 5-fluorouracil.


Intracellular bactericidal effects of rifampicin in both normal and chronic ganulomatous disease polymorphs.


Intracellular enzymes in serum, lymph and urine after renal ischaemia.


Intracellular viral RNA species in mouse cells nonproductively transformed by the murine sarcoma virus. The size and quantity of virus-specific RNA in five non-virus-producing mouse cells transformed by the Moloney isolate of murine sarcoma virus (MSV) was determined. Hybridization of RNA from transformed cells with the [(3)H]DNA product of the RNA-directed DNA polymerase of the murine sarcoma-leukemia virus was used to detect and quantitate virus-specific RNA. The amount of virus-specific RNA in non-virus-producing cells was less than one-sixth of that found in virus-producing cells. A striking correlation was found between the amount of intracellular virus-specific RNA and the degree of agglutination by conconavalin A previously reported for the four non-virus-producing NIH/3T3 cell lines (Salzberg and Green, 1974). A major RNA subunit sedimenting at 26 to 28S was detected in all five MSV-transformed non-virus-producing cells. This could represent the RNA genome of defective MSV.


Intracisternal tubules of lamprey chloride cells.


Intralabyrinthine temperature changes during cryosurgery in the guinea pig.


Intracranial metastatic meningioma.

Intracranial metastatic meningioma.


Intralesional triamcinolone acetonide using the Port-O-Jet and needle injections in localized dermatoses.


Intramedullary cervical cord metastasis from a nasopharynx carcinoma.


Intranasal meningoencephalocele.

Intranasal meningoencephalocele.


Intrapartum epidural anesthesia. An evaluation of effects on uterine activity.


Intrarenal reflux and the scarred kidney.


Intrascrotal temperature, testicular histology and fertility of heart-acclimatized rats. This study investigated intrascrotal and deep body temperatures, reproductive ability, and histological patterns in the testes of heat-acclimatized rats.  Albino rats aged 100-110 days were acclimatized to 35 degrees C. and a relative humidity of 25-40% for at least 3 months.  There was free access to food and water and 14 hours of light daily.  A control group was kept at an ambient temperature of 22 degrees C. and relative humidity of 35-50%.  Deep-body temperature was measured with a thermistor probe inserted 4 cm into the rectum.  Intrascrotal temperatures were measured with a thermocouple contained in a 27-gauge hypodermic needle inserted into the scrotum after the testes had been displaced.  Readings were taken on alternate days for 30 days.  Deep-body and intrascrotal temperatures were higher in experminetal than in control animals.  Both groups maintained differences between body and intrascrotal temperatures.  The intrascrotal temperatures of heat-acclimatized rats resembled the deep-body temperatures of the controls and, therefore, were similar to the environmental temperatures of cryptorchid testes.  The mating rate of heat-acclimated males was lower than that of controls and fewer females conceived when mated with experimental males.  However, in females which did conceive the type of male had no effect on implantation, pregnancy loss, or number of young.  In about 20% of the experimental animals seminiferous tubules showed necrobiosis of germinal epithelium.  Slight hyperplasia of Leydig cells was noted.  The epididymal epithelium was intact and normal spermatozoa were present in the lumen.  It is suggested that the gradient between the internal body termperature and the termperature of the testes is essential for spermatogenesis.  Similar temperatures without the gradient, as in cryptorchid testes or heated scrotum, have been shown to be detrimental to spermatogenesis.


Intrasellar arachnoidocele and the so-called empty sella syndrome.


Intrasynaptosomal conversion of tyrosine to dopamine as an index of brain catecholamine biosynthetic capacity.


Intrathoracic lymphnodal hamartoma: A case report.


Intrathoracic and venous pressure relationships during responses to changes in body position.


Intratracheal cuffs and aeromedical evacuation.


Intrauterine intraventricular haemorrhage and disseminated intravascular coagulation in a triplet pregnancy.


Intrauterine transfusion.

Intrauterine transfusion.


Intrauterine injection of prostaglandin F2alpha for termination of early pregnancy in out-patient. Prostaglandin F2alpha (PGF2alpha) administered as single intrauterine injection was used for termination of very early pregnancy in 34 outpatients.  12 patients were induced with 1.0 mg, 18 patients with 2.0 mg and 4 patients with 4.0 mg of PGF2alpha.  After 2 weeks, abortion was complete in 58% induced with 1.0 mg, in 78% induced with 2.0 mg, and in all 4 patients induced with 4.0 mg.  After 3 weeks, abortion was complete in 83% induced with 1.0 mg and in 100% induced with 2.0 mg.  There was 1 failure, which occurred in the group treated by using 1.0 mg PGF2alpha.  Immediate side-effects were kept at an acceptable level with a very mild premedication.  No serious complications occurred but curettage was performed on 2 patients because of bleeding.  Spontaneous menstruation started in the 1.0 mg group within an average of 33 days (range 25-61).  The use of 2.0 mg PGF2alpha for the routine termination of very early pregnancy is recommedned.


Intravaginal PGE2 in early abortion.

Intravaginal PGE2 in early abortion. Intravaginal prostaglandin E2 (PGE2) was administered to 10 women in early (less than 50 days) pregnancy.  Complete abortion was affected in 8, an incomplete abortion in 1, and 1 was a failure.  Significant systemic side effects were noted in all subjects.  Urinary hcG excretion rates prior to and on the 2nd and 14th day after PGE2 showed a decrease in all successfully aborted subjects and an initial decrease but a subsequent rise in the failure subject.  Plasma concentrations of progesterone and estradiol-17 Beta showed no significant alterations during the early (less than 2 hours) administration of PGE2 but decreased significantly in all subjects just prior to expulsion, and at intervals thereafter.  Estradiol-17Beta and progesterone alterations appeared to parallel each other indicating a common source, the corpus luteum.  The mechanism by which PGE2 may effect early abortion is discussed.


Intravenous infusion of drugs by a retrograde technique.


Intravesical formalin.

Intravesical formalin.


Intrinsic fluorescence of a protein devoid of tyrosine and tryptophan: horse hepatocuprein.


Invasive carcinoma of the breast: prognostic significance of tumor size and involved axillary lymph nodes.


Inverted growth of dendrites of the retinal ganglion cells in Callionymus lyra L, (dragonet).


Investigation of cyclohexylamine sulfate for dominant lethal effects in the mouse.


Investigation of factors related to stimulus overinclusion.


Investigation of the generalizability of attitudes toward body products as a function of psychopathology and long-term hospitalization.


Investigation of the mechanism of false positive 125I-labelled fibrinogen scans.


Iodoacetic acid influence on the aerobic glycolysis in surviving retinae of normal rats and of carriers of inherited retinal degeneration.


Ion transport in cortical collecting tubule; effect of amiloride.


Investigation of the physiological basis for increased exercise threshold for angina pectoris after physical conditioning. Eight patients with coronary heart disease and exertional angina pectoris successfully completed an 11-15 wk program of endurance exercise conditioning. Angina threshold was determined by upright bicycle ergometer exercise and by atrial pacing. The product of heart rate and arterial systolic blood pressure at the exercise angina threshold was higher after conditioning. suggesting that conditioning increased the maximum myocardial O(2) supply during exercise. However, when angina was induced by atrial pacing, heart rate, arterial blood pressure, coronary blood flow, and myocardial O(2) consumption at the angina threshold were the same before and after conditioning. Myocardial lactate extraction during atrial pacing was abnormal in the same five patients before and after conditioning. Conditioning caused no detectable changes in coronary collaterals as judged by coronary arteriograms. The increase in exercise angina threshold appeared to be due to a functional adaptation in either myocardial O(2) supply or the relationship between hemodynamic work and myocardial O(2) consumption. The adaptation was limited to exercise, and did not occur during a different stress to myocardial O(2) supply, atrial pacing.


Ionic and non-ionic mitochondrial phosphate in relation to Ca2 plus and arsenate accumulation.


Ipsilateral connections of the gyrus proreus in the cat.


Ionic permeability of canine antrum.

Ionic permeability of canine antrum.


Iron and copper availability from various sources.


Iron and aconitase activity.

Iron and aconitase activity. Aconitase activated with Fe(2+), cysteine and ascorbate incorporates 1 g-atom of Fe(2+)/mol. Loss of this Fe(2+) by transfer to ferrozine, a Fe(2+) chelator, results in loss of activity. Ascorbate increases the rate of transfer of the essential Fe(2+) whereas citrate retards the rate of transfer. Transfer of Fe(2+) from inactive aconitase, 2 g-atoms of Fe/mol, can be accomplished in the presence of urea and ascorbate. The correlation of activity with the presence of an added g-atom of Fe(2+)/mol leads to the conclusion that active aconitase has only one active site per mol.


Iron kinetics and the anaemia of rheumatoid arthritis.


Irradiation of specimens by excitation light before and after staining with pararosaniline Feulgen: a new method to reduce non-specific fluorescence in cytofluorometry.


Is professionalization the answer to improving health care?


Is the changing work ethic evolutionary or revolutionary?


Is TMA a scientific group? You bet!

Is TMA a scientific group? You bet!


Is there retention or production of nitrogen or other gases except O2 and CO2 in human steady-state conditions?


Isoelectric focusing spectra of rabbit antibodies to Salmonella abortus-equi detected by anti-idiotypic sera.


Isolation and characterization of a hypoglycemic agent from Xanthium strumarium.


Isolation and characterization of parvalbumins from the skeletal muscle of higher vertebrates.


Isolation and characterization of a 3-chlorobenzoate degrading pseudomonad.


Isolation and purification of the cyanogen bromide fragments from troponin I.


Isolation and properties of an esterase isoenzyme of rat serum.


Isolation and structure determination of a metabolite of diftalone in humans.


Isolation of ethyl galactoside from Trigonella corniculata seeds.


Isolation of myricadiol, myricitrin, taraxerol, and taraxerone from Myrica cerifera L. root bark.


Isolation of properties of a soluble antigen of Trichinella spiralis.


Isolation of proteins with high affinity for dRNA.


Isolation of rabbit reticulocyte 9 S mRNA.


Isolation of the 67gallium accumulating fraction in normal rat liver.


Isolation of two functionally different kininogens from human plasma--separation from proteinase inhibitors and interaction with plasma kallikrein.


Isolation of Acholeplasma laidlawii from guinea-pigs.


Isolation of Dactylaria gallopava from broiler-house litter.


Isolation of RNA-binding proteins from rat liver nuclear 30 S-particles.


Isolation of 1,4-androstadiene-3,17-dione from urine of an epileptic boy.


Isolation on cellulose of ovalbumin and globin mRNA and their translation in an ascites cell-free system.


Isolation, characterization and comparative studies of the N-terminal peptides from soluble pig skin collagen.


Isolation, characterization, and biological activities of five mitogens from pokeweed.


Isolation, identification, synthesis and biological activity of volatile compounds from the heads of Atta ants.


Isolation, purification, and assay of an initiation factor from rat liver cytosol that promotes binding of aminoacyl-tRNA to 40 S ribosomal subunits.


Isometric contraction of the abductor digiti minimi muscle in man. Isometric contraction of the abductor digiti minimi muscle (ADM) has been studied in six normal subjects. Twitch contraction times of ADM ranged from 60 to 68 ms and twitch torque ranged from 2·33 to 6·24 × 10(-3) Nm. In three subjects torque declined by an average of 31% after tetanization at 50 Hz for 30 seconds but there was no similar diminution in the evoked muscle action potential suggesting that the fatigue arose from intrinsic muscular mechanisms. A marked decline in tetanic torque occurred with continued tetanization in two subjects for a total of five minutes, but this change was accompanied by a decrease in the muscle action potential. In six subjects threshold stimulation to the ulnar nerve at the wrist and to various sites over the motor point of ADM allowed 55 threshold twitch contractions to be identified after averaging. A unimodal range of contraction times ranging from 40-100 ms was found and this was confirmed by additional experiments in two subjects in whom 30 threshold twitch contractions were identified using a needle electrode to stimulate various sites in the motor point. Tetanization at 50 Hz was performed using threshold stimulus levels. Nine threshold tetanic contractions were evoked in two subjects. In eight tetanic torque progressively fatigued to between 14 and 20% within 60-90 seconds, but, in one tetanic contraction, torque proved relatively fatigue resistant. These results suggest that there is a homogeneous group of motor units in ADM (with respect to contraction time) and that this group contains what are probable fast twitch fatigue sensitive and fatigue resistant motor units. No evidence of a distinct group of slow twitch units was found.


Ixodes (Pholeoixodes) conepati Cooley & Kohls (Acarina: Ixodidae): description of the immature stages from rock squirrels in Texas.


Isopycnic centrifugation of free and membrane-bound polysomes from rat liver.


IUPAC-IUB Commission on Biochemical Nomenclature (CBN). Nomenclature of tocopherols and related compounds. Recommendations (1973).


Jaundice and antibodies directed against factors 8 and 9 in patients treated for haemophilia or Christmas disease in the United Kingdom.


Jet noise at schools near Los Angeles International Airport.


Juxtaposed epicardial-pericardial clips. An adjunct to the differential diagnosis of hemopericardium, pericardial tamponade, and primary low cardiac output syndrome after open-heart surgery.


Keeping up: reported journal readings of psychiatrists.


Keratoacanthoma in a smallpox vaccination site.


Ketamine dissociative analgesia in the cow.


Kinetic evaluation of haemostasis during surgery and wound healing.


Kinetic properties of lysozyme from the hemolymph of Crassostrea virginica.


Kinetics of aerobic oxidation of ascorbic acid in the presence of nonionic surfactants.


Kinetics and mechanisms of solvolysis of 5-iodocytosine.


II. Control of medicinal products in the United Kingdom.


Kinetics of complexation of sodium ions with valinomycin in methanol by 23Na NMR spectroscopy.


Kinetics of diphenylhydantoin in uraemic patients: consequences of decreased plasma protein binding.


Kinetics of in vitro nitro reduction of 2,4-dinitrophenol gy rat liver homogenates.


IV. Recent medicine legislation in the United Kingdom and its effect on manufacturing practice.


Kinetics of phagocytosis. II. Analysis of in vivo clearance with demonstration of competitive inhibition between similar and dissimilar foreign particles.


Know your lease.

Know your lease.


Kinetics of the inhibition of citrate synthase from pig heart by substrate analogues.


Kinetics of the attachment of intrinsic factor-bound cobamides to ileal receptors. To determine whether the molecular configuration of vitamin B(12) influences the attachment of intrinsic factor-vitamin B(12) complex to ileal microvillous membrane receptor sites, we have examined the kinetics of uptake of intrinsic factor-bound cyanocobalamin by brush borders and microvillous membranes isolated from guinea pig ileum, and have compared this uptake with that of intrinsic factor alone and with that of intrinsic factor complexed with various analogs of cyanocobalamin. We first studied the kinetics of binding of cyanocobalamin and other cobamides to human gastric intrinsic factor. The binding of cyanocobalamin showed saturation kinetics and, at relatively high concentrations of cyanocobalamin, a Scatchard plot of binding was linear. The dissociation constant for the intrinsic factor-cyanocobalamin complex was 0.066 nM. When the binding of various vitamin B(12) analogs to intrinsic factor was determined by competition experiments, the analogs could be separated into two categories: those with affinities similar to that of cyanocobalamin and those with affinities much lower than that of cyanocobalamin. The affinity of cyanocobalamin for intrinsic factor was not altered by various substitutions at the -CN position, while removal of a single amido group on the corrin ring of substitution of the dimethylbenzimidazole base greatly reduced affinity. Removal of the base totally abolished binding. These findings, confirming those reported by others, are consistent with the concept that the cyanocobalamin molecule fits into a "pocket" in the intrinsic factor molecule, with the nucleotide base facing inward and the -CN side of the planar corrin ring facing outward. We then investigated the attachment of intrinsic factor-bound cyanocobalamin to ileal receptor. Attachment to microvillous membranes showed saturation kinetics with a dissociation constant of 0.25 nM. Attachment was rapid and was 70% complete within 5 min; the second-order rate constant for attachment was 1.3 x 10(6) M(-1) s(-1). The half-time for dissociation of intrinsic factor-bound cyanocobalamin from the ileal receptor was approximately 35 min. Free intrinsic factor inhibited the attachment of intrinsic factor-bound cyanocobalamin, but the rate of attachment of free intrinsic factor was slower than that of intrinsic factor bound to cyanocobalamin. When intrinsic factor was complexed with various analogs of cyanocobalamin, the affinities of these complexes for ileal microvillous membranes were similar to that of intrinsic factor-bound cyanocobalamin. These findings suggest that the molecular configuration of vitamin B(12) is not a major determinant in the interaction between intrinsic factor-bound vitamin B(12) and its ileal receptor site.


Kynurenine pyruvate transaminase in rat brain.


L-cysteine, an antagonist to the toxic effects of an alpha-methylene-gamma-lactone isolated from Hymenoxys odorata DC. (Bitterweed).


L-form induction, morphology, and development in two related strains of Erysipelothrix rhusiopathiae. Two related strains of Erysipelothrix rhusiopathiae, one the parent and the other an L-form revertant, were studied for their propensity or ability to produce L-forms under the influence of penicillin. The parent strain produced L-forms in nutrient solid media in an osmolarity range between 0.85 and 5.0% NaCl concentration whereas the revertant strain did so between 0.5 and 3.0% NaCl concentration. When various hyperosmolar media were tried without penicillin, recovery of L-forms from the revertant strain was optimal at a salt concentration of 2.0%, whereas the parent strain occasionally produced a few L-forms on 3.0% salt medium only. The process of penicillin-induced transformation from bacteria to L-form followed an unusual morphological sequence, beginning with beading of the bacterial body, followed by disintegration into granules from which the L-form colony derived. No large bodies were seen during the initial process of L-form induction, but they evolved later from the original granules and had the potential to reproduce L-type growth. The spontaneous development of L-forms in hyperosmolar media had a different morphological sequence starting with elongation of the bacteria into filaments which later developed polar and central dilatations from which granules and L-type growth developed. The differences in biological behavior between these related bacterial strains suggest that the revertant strain developed new properties, probably of genetic origin. Consequently, the assumption that L-forms revert to the "parent" bacteria may not always be justified. It can be made only after the biological properties of the parent and the revertant organisms have been properly identified.


L-tryptophan: effects on body temperature in rats.


La Amistad: starting an inpatient program for severely disturbed young adults.


Laboratory examination of the thyroid. 2. In vivo tests. Last of a series.


Laboratory medicine: Blood group analysis and pregnancy.


Lack of cardiac inotropic effect of tolbutamide in intact man.


Lack of effect of intraventricular 6-hydroxydopamine pretreatment on rat striatal cholinergic parameters.


Lack of effect of pineal denervation on the responses of the female albino rat to exposure to constant light.


Lack of effect of the appetite stimulant pizotifen (BC 105) on the absorption of isonicotinylhydrazine.


Lack of specificity of the acid perfusion test in duodenal ulcer patients.


Lady of the night.

Lady of the night.


Lactate dehydrogenase subunit and activity changes in hypertrophied heart of the hypoxically exposed rat.


Lactose malabsorption in Finnish-speaking and Swedish-speaking populations in Finland.


Larger body size and earlier menarche: the end may be in sight.


Lambda site-specific recombination: local transcription and an inhibitor specified by the b2 region.


Laser-excited Raman spectroscopy of biomolecules. VI. Some polypeptides as conformational models.


Lateral diffusion in the hydrophobic region of membranes: use of pyrene excimers as optical probes.


Law in brief.

Law in brief.


Lead and delta-aminolevulinic acid concentrations in human parotid saliva.


Left upper quadrant appendicitis.

Left upper quadrant appendicitis.


Left atrial thrombi in open mitral valve surgery.


Lead levels in deciduous teeth.

Lead levels in deciduous teeth.


Left ventricular blood flow velocity during atrial arrhythmias in man.


Laryngotracheal autograft for postcricoid carcinoma. A reevaluation.


Left ventricular pressures during human coronary cinearteriography.


Legal issues in contracting with HMOs. 1. The Health Maintenance Organization Act of 1973 established a 5-year $325 million program of federal assistance to aid in the planning and organization of HMOs.  The Act also required employers to offer their employees the alternative of an HMO membership to existing health benefits plans.  Health Maintenance Organizations are defined by the following characteristics: 1) they are total health care delivery systems; 2) they consist of a voluntarily enrolled population; 3) agreed-upon services are provided by a prearranged and  prepaid fee; and 4) the organizations bear the risk of providing the services for the prearranged fee.  HMOs differ from existing health  care delivery systems in that the system is closed, i.e., physicians and referral services are limited to those participating in the organization.  HMOs must have a 1/3 consumer membership on their policy-making boards.  Most also have physician representation on the boards.  There exists a financial incentive to reducing the use of hospital services.  HMOs are required to provide all services, including abortion and sterilization, but a hospital which takes care in negotiating its contract with the HMO will be exempt from having to do so.


Legal issues in contracting with HMOs. 2.


Legal protection: facts you should know. Medical records--how long should they be kept?


Legal responsibility for suicide.

Legal responsibility for suicide.


Length, weight and secondary sex character development in male and female phenotypes in three sex chromosomal genotypes (XX,XY,YY) in the killifish, Oryzias latipes.


Lentil pulmonary granulomatosis.

Lentil pulmonary granulomatosis.


Leptospiral motility.

Leptospiral motility.


Lesions in the ventromedial hypothalamus and response to frustrative nonreward.


Let them eat programs: attendants' perspectives and programming on wards in state schools.


Lethal midline granuloma. Pathogenesis and radiation therapy.


Lethality, antiesterase and hemicholinium-like actions of a series of bisquaternary ammonium compounds.


Letter: 'To whom it may concern' concerns you.


Letter: "Normal laboratory values".

Letter: "Normal laboratory values".


Letter: the interscalene approach to the brachial plexus.


Letter: A granulocytopaenic syndrome in calves.


Letter: A case of schizophrenia treated with flupenthixol (Depixol) injections.


Letter: A new bicyclo lactone from leukomycin-A3 by alkali treatment.


Letter: Abdominal decompression in pregnancy.


Letter: A relationship between platelet volume and platelet number.


Letter: Abrupt withdrawal of antiparkinsonian drugs.


Letter: Absolute configuration of coriolin, a sesquiterpene antibiotic from Coriolus consors.


Letter: Accidental injection of potassium.


Letter: Achalasia of the cardia.

Letter: Achalasia of the cardia.


Letter: Acupuncture.

Letter: Acupuncture.


Letter: Acute psychosis.

Letter: Acute psychosis.


Letter: Adenosine triphosphate in paroxysmal noctural hemoglobinuria red blood cell.


Letter: Adjustment of plasma calcium measurements.


Letter: Adverse reactions after propranolol withdrawal.


Letter: Agranulocytosis after treatment with clomipramine infusion.


Letter: Allergic interstitial nephritis with diuretics.


Letter: Allergic reactions to insect bites and stings of fire ants.


Letter: Allopurinol and drug induced alopecia.


Letter: Amitriptyline and imipramine poisoning in children.


Letter: An adaptation of the Rose-Bengal test for the diagnosis of brucellosis at abattoirs.


Letter: Analgesic nephropathy.

Letter: Analgesic nephropathy.


Letter: An error in methodology.

Letter: An error in methodology.


Letter: Anemia pointer: check the MCV.

Letter: Anemia pointer: check the MCV.


Letter: Anesthesia in preterm infants.

Letter: Anesthesia in preterm infants.


Letter: Anogenital herpes zoster in two cases of Wegener's granulomatosis.


Letter: Another source of medication errors.


Letter: Anoxic-ischaemic brain injury.

Letter: Anoxic-ischaemic brain injury.


Letter: Antiasthmatic effect of amitriptyline.


Letter: Antibiotics and farmers.

Letter: Antibiotics and farmers.


Letter: Antitumor versus cytotoxicity.

Letter: Antitumor versus cytotoxicity.


Letter: Are there social differences in mothering?


Letter: Are vitamin E supplements beneficial?


Letter: Area and volume relationship in the crayfish retina.


Letter: Area postrema and blood pressure.


Letter: Ascorbic acid and nitrosamine.

Letter: Ascorbic acid and nitrosamine.


Letter: Aspirin and what else?

Letter: Aspirin and what else?


Letter: Attitudes to abortion.

Letter: Attitudes to abortion.


Letter: Autonomic neuropathy and autovagotomy.


Letter: Behaviour modification in one psychiatric hospital.


Letter: Beclomethasone dipropionate.

Letter: Beclomethasone dipropionate.


Letter: Biosynthesis of bacteriochlorophyll.


Letter: Blood vitamins in Aboriginal children and mothers.


Letter: Bronchogluteal fistula in coccidioidomycosis.


Letter: Calcium and myocardial infarction.


Letter: Calorie and joule.

Letter: Calorie and joule.


Letter: Cancer of the colon visualized by strontium scintigraphy.


Letter: Canis familiaris and Homo sapiens.


Letter: Cancer of the thyroid in three generations.


Letter: Carbamate poisoning.

Letter: Carbamate poisoning.


Letter: Care of seriously injured patients.


Letter: Catheter perforations of heart wall.


Letter: Caution indicated in handling ophthalmic drugs.


Letter: Chasing the dollar--a case report.


Letter: Chloride-phosphate ratio in hypercalcemia.


Letter: Chronic inflammatory bowel disease: acute pericarditis and pericardial tamponade.


Letter: Choreiform movements after depot injections of flupenthixol.


Letter: Chronic rheumatic fever with erythema marginatum in an adult.


Letter: Circular dichroism study on inclusion complexes of beta-cyclodextrin with anti-inflammatory fanamates.


Letter: Clinical public health doctors and community medicine.


Letter: Comments on scabies.

Letter: Comments on scabies.


Letter: Collection of tracheobronchial secretions.


Letter: Computer assisted tomography.

Letter: Computer assisted tomography.


Letter: Congenital toxoplasmosis.

Letter: Congenital toxoplasmosis.


Letter: Conjugal malignant mesothelioma.


Letter: Conservative operation in operable cancer of the breast.


Letter: Consumer understanding of surgical services.


Letter: Contraceptives and health.

Letter: Contraceptives and health.


Letter: Control of glomerular filtration rate.


Letter: Controlling heart disease.

Letter: Controlling heart disease.


Letter: Conversion of the E prostaglandins.


Letter: Coronary artery surgery.

Letter: Coronary artery surgery.


Letter: Correct dosage of insulin.

Letter: Correct dosage of insulin.


Letter: Correlation of antistreptolysin-O titer to HL-A13 in psoriasis.


Letter: Correlation between iron content of epithelial cells and iron absorption.


Letter: Cystic fibrosis and coeliac disease.


Letter: Dark adaptation shifts apparent spatial frequency.


Letter: Death after E.C.T.

Letter: Death after E.C.T.


Letter: Deep venous thrombosis: a hypothesis.


Letter: Contrast media activation of serum complement system.


Letter: Defibrination after head trauma.


Letter: Depigmentation caused by a phenolic detergent-germicide.


Letter: Dermatitis herpetiformis and the enteropathy of celiac disease.


Letter: Detection of diluted meperidine hydrochloride.


Letter: Detection of new virus using electron microscope examination.


Letter: Dextrocardia--classify it as it really is.


Letter: Diagnosis and treatment of mycosis fungoides.


Letter: Diagnosis of syphilis.

Letter: Diagnosis of syphilis.


Letter: Diagnosis of Wilson's disease.

Letter: Diagnosis of Wilson's disease.


Letter: Dielectric loss transients.

Letter: Dielectric loss transients.


Letter: Dietary fat and coronary heart disease.


Letter: Dimensions of sports medicine.

Letter: Dimensions of sports medicine.


Letter: Distribution of the haemoglobin components of trout blood among the erythrocytes: observations by single-cell spectroscopy.


Letter: Dubin-Johnson syndrome and viral hepatitis.


Letter: Drugs and xylose absorption from intestine.


Letter: Ecologic distribution of reprints.


Letter: Dystocia in a cat.

Letter: Dystocia in a cat.


Letter: Effect of directional-flow patterns upon motion thresholds.


Letter: Effect of lithium on disturbed severely mentally retarded patients.


Letter: Effect of methohexitone on infants delivered by caesarean section.


Letter: Effect of Bisolvon.

Letter: Effect of Bisolvon.


Letter: Effects of antacids on naproxen absorption.


Letter: Effects of exertion on hormone secretion.


Letter: Electrocardiographic diagnosis of acute myocardial infarction in patients with implanted pacemakers.


Letter: Effects of hydraulic pressure and nozzle orifice size on delivery rates of sprayed materials.


Letter: Encroachments on the patient's responsibility.


Letter: Endoscopic collection of gastrointestinal fluid.


Letter: Endotracheal tube sizes for children.


Letter: Endovenous diathermy sclerosis as a unit of the armamentarium for the attack on varicose veins.


Letter: Enlarged epiphyses: megepiphyseal dwarfism or homocystinuria?


Letter: Epidural blood patch for post-lumbar-puncture headache.


Letter: Ergotamine-induced headaches.

Letter: Ergotamine-induced headaches.


Letter: Ethaverine therapy for multiple leiomyomas.


Letter: Evaluation of five commercial pregnancy test kits using urine samples containing methadone.


Letter: Excretory urography in renal failure.


Letter: Experiences in a rural preceptorship: eleven weeks in a PHS Indian Hospital.


Letter: Endolymphatic hydrops and glaucoma production.


Letter: Fatal infectious mononucleosis in familial lymphohistiocytosis.


Letter: Fatality after revivon.

Letter: Fatality after revivon.


Letter: Feeding colostrum.

Letter: Feeding colostrum.


Letter: Fewer doctors and infant survival.


Letter: Floppy mitral-valve syndrome.

Letter: Floppy mitral-valve syndrome.


Letter: Flurothyl (Indoklon) in depression.


Letter: Foreign medical graduates.

Letter: Foreign medical graduates.


Letter: Genetic control of natural resistance to Leishmania donovani.


Letter: Genetic counseling.

Letter: Genetic counseling.


Letter: Gold vasculitis.

Letter: Gold vasculitis.


Letter: Gonadal dosage in radiography of the coxfemoral joint of the bull.


Letter: Gouty arthritis and colchicine.

Letter: Gouty arthritis and colchicine.


Letter: Grocery-bag neuropathy.

Letter: Grocery-bag neuropathy.


Letter: Halothane MAC in the rabbit.

Letter: Halothane MAC in the rabbit.


Letter: Growth with absent growth hormone by radioimmunoassay.


Letter: Healing of duodenal ulcer.

Letter: Healing of duodenal ulcer.


Letter: Health on the cheap.

Letter: Health on the cheap.


Letter: Healthy ways to handle stress.

Letter: Healthy ways to handle stress.


Letter: Hematuria following thiabendazole.


Letter: Hemorrhoids.

Letter: Hemorrhoids.


Letter: Hemiplegic migraine: cerebrospinal fluid abnormalities.


Letter: Heparin and the hemolytic uremic syndrome.


Letter: Heroin addiction and nephropathy.


Letter: Heroin withdrawal using ear acupuncture.


Letter: Hilar enlargement in amyloidosis.


Letter: House calls.

Letter: House calls.


Letter: How dangerous is propranolol?

Letter: How dangerous is propranolol?


Letter: Hub modification to prevent air bubble artifacts during transduodenal ampullary cannulation.


Letter: Hyperostosis frontalis interna and serum enzymes in obese women.


Letter: Hyperglycaemia and uraemia in hyperosmolar dehydration.


Letter: Hypersomnia and MAOI antidepressants.


Letter: Hyperthyroidism after pyelography.


Letter: Hypoglycaemia action of onion on rabbits.


Letter: HL-A W27, spondylitis and enteritis.


Letter: Illegitimus non carborundum.

Letter: Illegitimus non carborundum.


Letter: Immunotherapy.

Letter: Immunotherapy.


Letter: Implications for pediatric practice.


Letter: Improving your status--on all levels of the profession.


Letter: Incidence of diagnosed clinical otosclerosis.


Letter: Indwelling arterial catheters.

Letter: Indwelling arterial catheters.


Letter: Influenza in families.

Letter: Influenza in families.


Letter: Hypertension as the cause of cerebral hemorrhage.


Letter: Inhibition of phenylalanyl-tRNA binding and elongation factor Tu-dependent GTP hydrolysis by antibodies specific for several ribosomal proteins.


Letter: Interferon induction by an antitumor antibiotic, lymphomycin.


Letter: Inhibition of protein L7-L12 binding to 50 S ribosomal cores by antibodies specific for proteins L6, L10 and L18.


Letter: Intestinal absorption of peptides: A major mode of protein absorption in man.


Letter: Intradermal influenza vaccination.


Letter: Intrauterine contraceptive devices. Experience with the insertion of 330 IUDs is reported.  The devices used were 1) 4 Lippes loops size A; 2) 146 Lippes loops size C; 3) 30 Inhibands; 4) 24 15-mm Dalkon shields; and 5) 126 30-mm Dalkon shields.  For the Lippes loop users, the expulsion rate was 6.6%, the perforation rate was .66%, the pregnancy rate was 3.3%, and the continuation rate was 62.2%.  For the Inhiband users, there were no expulsions or perforations and the pregnancy rate was 16.6%; the continuation rate was 83.4%.  For the Dalkon shield wearers, the expulsion rate was .66%, there were no perforations, the pregnancy rate was 1.3%, and the continuation rate was 74.4%.  The device was left in situ when pregnancy occurred.  6 of the 11 pregnancies which occurred spontaneously aborted at or before the third month.  4 of the 5 remaining pregnancies proceeded to a vaginal delivery at term, and the fifth went into spontaneous labor at 37 weeks' gestation and a premature infant was born.  The 15-mm Dalkon shield proved satisfactory for 22 of the 24 in the "never pregnant" group.  Several types of bacterial flora in the upper vagina were found to have increased after IUD insertion.


Letter: Inversion of the appendix.

Letter: Inversion of the appendix.


Letter: Iodine requirements in pregnancy.


Letter: Isoflurane metabolism.

Letter: Isoflurane metabolism.


Letter: Isolation system for General Hospitals.


Letter: Isoniazid prophylaxis.

Letter: Isoniazid prophylaxis.


Letter: Ketotic hypoglycaemia.

Letter: Ketotic hypoglycaemia.


Letter: Lactose intolerance in San populations.


Letter: Leukocyte count in smokers.

Letter: Leukocyte count in smokers.


Letter: Lentigo maligna associated with porphyria cutanea tarda.


Letter: Lidocaine: a case of intraamide hydrogen bonding.


Letter: Linear porokeratosis.

Letter: Linear porokeratosis.


Letter: Lithium carbonate and hormonal release.


Letter: Lower abdominal tenderness following traumatic rupture of the spleen.


Letter: Malaria in the United Kingdom.

Letter: Malaria in the United Kingdom.


Letter: Malignant heating pad.

Letter: Malignant heating pad.


Letter: Malignant melanoma and diet.

Letter: Malignant melanoma and diet.


Letter: Massive use of chemoprophylaxis against tuberculosis.


Letter: Medical brain drain.

Letter: Medical brain drain.


Letter: Mechanisms affecting "closing-capacity" test.


Letter: Medical students and small pox vaccination.


Letter: Megakaryocytes in dyserythropoietic anemia.


Letter: Metabolism of delta 1-tetrahydrocannabinol by mouse hepatic microsomes: identification of 6alpha-hydroxytetrahydrocannabinol.


Letter: Membrane glycoproteins and cellular ageing.


Letter: Metaclopramide and prolactin.

Letter: Metaclopramide and prolactin.


Letter: Metindamide as a diuretic.

Letter: Metindamide as a diuretic.


Letter: Metric conversion.

Letter: Metric conversion.


Letter: Microbial conversion of antibiotics. II. Deacylation of maridomycin by Actinomycetes.


Letter: Miners' syndrome.

Letter: Miners' syndrome.


Letter: Misdiagnosis of leg pains in child.


Letter: Misuse of the glucose tolerance test?


Letter: More on ascorbate.

Letter: More on ascorbate.


Letter: More vitamin C.

Letter: More vitamin C.


Letter: Multiple prescribing.

Letter: Multiple prescribing.


Letter: Multiple teratomas of the head and neck.


Letter: Myocardial necrosis: the need for definition.


Letter: Mythology and SIDS.

Letter: Mythology and SIDS.


Letter: Nanaomycins A and B, new antibiotics produced by a strain of Streptomyces.


Letter: National health insurance.

Letter: National health insurance.


Letter: Need for more effective dissemination of birth control information.


Letter: Nomenclature of human immunoglobulins.


Letter: Nipples and editors.

Letter: Nipples and editors.


Letter: Non-cholera vibrio septicemia and meningoencephalitis.


Letter: Nonbasic aporphine alkaloids from Liriodendron tulipifera L.


Letter: Nursing staff and work load.

Letter: Nursing staff and work load.


Letter: NBT test in newborn platelets.

Letter: NBT test in newborn platelets.


Letter: Obstetric anesthesia organizations in the United States.


Letter: Occupational therapy--treatment of symptoms rather than disease?


Letter: Occurrence of an infectious bursal syndrome within an Australian poultry flock.


Letter: Osteodystrophia fibrosa in horses grazing Setaria sphacelata.


Letter: Parasites that avoid pulmonary passage.


Letter: Patch test reactions.

Letter: Patch test reactions.


Letter: Periodontitis and leukocytosis.

Letter: Periodontitis and leukocytosis.


Letter: Peritonitis and bowel perforation in peritoneal dialysis.


Letter: Pertussis vaccination.

Letter: Pertussis vaccination.


Letter: Pharyngitis as a source of postoperative infection around a breast implant.


Letter: Photosynthesis in leaves exposed to SO2 and NO2.


Letter: Platelets and 5-hydroxytryptamine.


Letter: Pleural lavage in carcinoma of the esophagus.


Letter: Podiatric literature.

Letter: Podiatric literature.


Letter: Polymorphous light eruption in identical twins.


Letter: Possible hepatitis after intradermal allergy skin testing.


Letter: Preliminary crystallographic data for spinach superoxide dismutase.


Letter: Preliminary observations on cardiac activities of Cannabis sativa L. root extracts.


Letter: Prevalence of streptococci and staphylococci in lesions of impetigo.


Letter: Primer on lupus erythematosus.

Letter: Primer on lupus erythematosus.


Letter: Problems with radioisotope scan for Meckel's diverticulum.


Letter: Protein-losing enteropathy in dermatitis herpetiformis.


Letter: Pseudomembranous colitis after the prophylactic use of clindamycin.


Letter: Psittacosis and virulent Newcastle disease virus in a consignment of parrots.


Letter: Psychiatry in the Soviet Union.

Letter: Psychiatry in the Soviet Union.


Letter: Pyeloplasty.

Letter: Pyeloplasty.


Letter: Puerperal rubella vaccination and anti-D immunoglobulin.


Letter: Questioning the value of the four-forty workweek for pharmacists.


Letter: Postoperative pneumothorax secondary to hypopharyngeal perforation during anesthetic intubation.


Letter: Radiographic location of the Dalkon shield.


Letter: Rapid, sensitive microassay for platelet 5HT.


Letter: Re: "Can epidemiology elucidate the water story?".


Letter: Reactions to intravenous agents (althesin and pancuronium).


Letter: Rebleeding of duodenal ulcers.

Letter: Rebleeding of duodenal ulcers.


Letter: Reduced particulate matter in lyophilized Kefzol.


Letter: Regulation of albumin-bound tryptophan.


Letter: Relative potencies of glucocorticosteroids.


Letter: Renal contribution to drug biotransformation.


Letter: Reporting deaths to the Coroner.


Letter: Research by practising physicians.


Letter: Respiratory distress syndrome and hyponatremia.


Letter: Retinal detachment.

Letter: Retinal detachment.


Letter: Ruptured cornual pregnancy.

Letter: Ruptured cornual pregnancy.


Letter: Selection of medical students.

Letter: Selection of medical students.


Letter: Self-administered clinical questionnaires for outpatients.


Letter: Sensitivity to rifampicin.

Letter: Sensitivity to rifampicin.


Letter: Septic abortion and the Dalkon Shield.


Letter: Serum uric acid and myocardial infarction.


Letter: Singing muscles in a katydid.

Letter: Singing muscles in a katydid.


Letter: Serum C3 levels in acute glomerulonephritis.


Letter: Sleeping sickness.

Letter: Sleeping sickness.


Letter: Small neighborhood pediatric practice in large, urban, low-income areas.


Letter: Spittlebug morph mimics avian excrement.


Letter: Splenic infarction in sickle-cell trait: are whites more susceptible?


Letter: Staphylococcal scalded skin syndrome in adults.


Letter: Sterilization of fibrescopes.

Letter: Sterilization of fibrescopes.


Letter: Stresses of management selection courses.


Letter: Steroid interference with plasma corticosteroid measurements.


Letter: Studies on a new alkaline degradation product of josamycin.


Letter: Studies of parents for clues to the origins of cancer in their offspring.


Letter: Sudden death in infancy syndrome (cot death).


Letter: Subclinical infection.

Letter: Subclinical infection.


Letter: Supplementation of food with iron.


Letter: Sun, wind, and the skin.

Letter: Sun, wind, and the skin.


Letter: Synthesis and psychotropic activity of 2-hydroxy-4,5-dimethoxyphenethanolamine, a potential endogenous psychotogen, and its methylenedioxy analog.


Letter: Teaching students how to talk and act with patients.


Letter: Temporarily dependent patients in general practice.


Letter: Tests of hearing in school.

Letter: Tests of hearing in school.


Letter: The application of the Rose-Bengal plate test to serums collected from carcases at abattoirs.


Letter: Tetracycline therapy for atypical mycobacterial granuloma.


Letter: The art of the CPC.

Letter: The art of the CPC.


Letter: The cure of folly.

Letter: The cure of folly.


Letter: The efficiency of the Dalkon shield.


Letter: The immediate care of seriously ill and injured patients.


Letter: The nature of gastrin's action on the lower esophageal sphincter.


Letter: The significance of biochemical vitamin deficiency.


Letter: The structure of minor components of the detoxin D group.


Letter: The unproductive minority.

Letter: The unproductive minority.


Letter: Therapy of Burkitt's lymphoma in the central nervous system.


Letter: Threat to use of opium.

Letter: Threat to use of opium.


Letter: Thoracic outlet syndrome.

Letter: Thoracic outlet syndrome.


Letter: Thrombocytopenia with subacute bacterial endocarditis.


Letter: Time, dose and fractionation factors in radiotherapy.


Letter: Transport of organic acids across cell membrane.


Letter: Treatment of acute lupus pneumonitis with azathioprine.


Letter: Treatment of giardiasis.

Letter: Treatment of giardiasis.


Letter: Treatment of hypernatremic dehydration.


Letter: Treatment of leprosy in the community.


Letter: Turkish children, immunization and ascorbic acid.


Letter: Tuberculin reaction in typhoid fever.


Letter: Unexpected sudden death in infancy syndrome (cot death).


Letter: Unusual cleft lip deformity.

Letter: Unusual cleft lip deformity.


Letter: Unusual urethral obstruction in a dog.


Letter: Uterine rupture: a coincidence?

Letter: Uterine rupture: a coincidence?


Letter: Vaginal Curschmann's spirals.

Letter: Vaginal Curschmann's spirals.


Letter: Vaginal douching.

Letter: Vaginal douching.


Letter: Value of proportionate mortality ratio in epidemiologic studies.


Letter: Ventricular tachycardia.

Letter: Ventricular tachycardia.


Letter: Visualization of the splenic blood pool with 131-I-rose bengal.


Letter: Voluntary sterilization.

Letter: Voluntary sterilization.


Letter: Who is the dental anaesthetist of the future?


Letter: Withdrawal of rifamide.

Letter: Withdrawal of rifamide.


Letter: Who is my doctor?

Letter: Who is my doctor?


Letter: Words per month.

Letter: Words per month.


Letters: Prevention of cardiovascular disease--the North Karelia project.


Leucomelanoderma in blacks. A recent epidemic.


Leukaemic reticuloendotheliosis ('Hairy' cell leukaemia): a distinct clinico-pathological entity.


Leukocyte alkaline phosphatase in the differential diagnosis of hypertension in pregnancy.


Leukocyte chemotaxis in vivo. I. Description of a model of cell accumulation using adoptively transferred 51Cr-labeled cells.


Leukocyte-poor CPD blood.

Leukocyte-poor CPD blood.


Levelling the tread. Elevation of the dropped metatarsal head by metatarsal osteotomy.


Lichen sclerosus et atrophicus in the Bantu.


Life- and death-promoting factors from the suboesophageal ganglion of the American cockroach.


Light and electron microscopic and element analysis of pseudoxanthoma elasticum (Darier-Grönblad-Strandberg syndrome).


Light and electron microscopical analysis of cell types in human seminoma.


Light and ultrasonic regulation of alpha-chymotrypsin catalytic activity. Proflavin as a light- and sound-sensitive competitive inhibitor.


Light microscopy of meiotic zoosporogenesis and mitotic gametogenesis in Ulva mutabilis Foyn.


Light microscope autoradiography of ribosomal DNA amplification in Xenopus laevis.


Light and x-ray diffraction studies on chick skeletal muscle under controlled physiological conditions. 1. The sarcomere length (s) of ehick slow and fast muscles (anterior and posterior latissimus dorsi (ant. lat. dorsi and post. lat. dorsi)) was measured by the method of light diffraction. In resting ant. lat. dorsi, s changed from 1.76 to 2.30 mum during stretch from minimum to maximum muscle lengths in situ, and in resting post. lat. dorsi from 2.18 to 2.63 mum.2. Resting tension started to rise in ant. lat. dorsi when s exceeded 1.7-1.8 mum, but in post. lat. dorsi not until s exceeded 2.6-2.7 mum.3. X-ray diffraction patterns showed that ant. lat. dorsi contains collagen filaments; collagen reflexions were not seen in patterns obtained from post. lat. dorsi with the same exposure time.4. The relation between active tension and sarcomere length was similar for ant. and post. lat. dorsi. The maximum active tension was observed when s = 2.05-2.15 mum in ant. lat. dorsi, and when s = 2.10-2.25 mum in post. lat. dorsi.5. X-ray diffraction patterns from both muscles showed that the periodic structures of the thick and thin filaments are similar to those in frog and rabbit skeletal muscles.6. The volume of the myofilament lattice in resting ant. lat. dorsi was 3.06 (+/- 0.14) x 10(9) A(3), in resting post. lat. dorsi 2.98 (+/- 0.09) x 10(9) A(3). These values are close to that of frog skeletal muscle. The lattice volume remained constant in ant. lat. dorsi and post. lat. dorsi over the range of sarcomere lengths found in situ.7. The equatorial diffraction patterns from the ant. lat. dorsi in rigor (glycerol extracted) were different from that of the resting muscle, and suggested that a large number of cross-bridges were attached to the thin filaments during rigor. During potassium contracture, however, the diffraction pattern remained similar to that from the resting ant. lat. dorsi.


Light scattering studies of retardation of sickling by aspirin-like drugs.


Light-scattering patterns of isolated oligodendroglia.


Light-dependent Ca++ content of rod outer segment disc membranes.


Lignocaine: effects on coronary blood flow in patients with recent myocardial infarction.


Limited surgical treatment of carcinoma of the breast: radiotherapy experiences.


Limited surgical treatment of carcinoma of the breast. Pathological aspects.


Lincomycin- and clindamycin-associated colitis.


Limiting nutrients during mating as a means of increasing recombinant recovery in crosses of Nocardia erythropolis. Minimal medium supplemented with sub-optimal levels of parental auxotrophic requirements increases recombinant recovery from matings of Nocardia erythropolis more than 500-fold when compared with nutrient agar matings.


Linkage between reproductive capacity at increased temperature and neurotropic activity in A-NWS HONi (HON1) influenza virus. We investigated the rate of covariation between the ability of the NWS strain of influenza virus to reproduce at increased temperature and its neurotropic properties. Results indicated that increased growth at 39 C was related to increased neurovirulence, and acquisition of the temperature-sensitive character was related to loss of neurovirulence.


Lipid absorption in newborn young of guinea pigs fed a protein-deficient diet during gestation.


Lipid metabolism of rat liver isolated and perfused in hypoxia.


Lipid metabolism in brains from mice chronically-fed ethanol.


Lipid utilization in adult Pieris brassicae with special reference to the rôle of linolenic acid.


Lipid peroxidation by human blood phagocytes. Cell suspensions enriched in human blood monocytes, obtained from normal peripheral blood by sedimentation on sodium diatrizoate-Ficoll gradients or from the blood of patients with neutropenia and monocytosis, accumulated malonyldialdehyde, a labile catabolite of lipid peroxidation, during incubations with polystyrene beads or heat-killed Staphylococcus epidermidis. Mixed blood leukocytes principally composed of granulocytes or granulocytes purified by density gradient sedimentation did not accumulate malonyldialdehyde during incubations with these particles, but did when ingesting particles containing linolenate. The phospholipid fatty acid composition of monocyte-enriched and purified granulocyte preparations from the same donors were compared. The molar fraction of arachidonate (20:4) in phospholipids from monocyte-rich preparations was 62% greater than that of purified granulocytes. The findings indicate that human monocytes, possibly because of a greater content of polyunsaturated fatty acids in their membranes, peroxidize a greater quantity of endogenous lipids than granulocytes during endocytosis. Normal human granulocytes have the capacity to peroxidize ingested lipids. However, mixed leukocytes from two patients with chronic granulomatous disease produced little malonyldialdehyde when engulfing linolenate-containing particles. Therefore the capacity to peroxidize lipid is related to cellular oxygen metabolism, a function in which chronic granulomatous disease granulocytes are dificient. Malonyldialdehyde chemically prepared by hydrolysis of tetramethoxypropane, by extraction from peroxidized linolenic acid, or purified from extracts of phagocytizing rabbit alveolar macrophages had bactericidal activity against Escherichia coli and S. epidermidis. Therefore, toxic catabolites of lipid hydroperoxides may potentiate the bactericidal activity of hydrogen peroxide in mononuclear phagocytes.


Lipids in plant tissue cultures. II. Unusual fatty acids in lipids of Hydnocarpus anthelminthica cultures.


Lipids of Sphaerophorus ridiculosis: plasmalogen composition. Lipid analyses of the anaerobic bacterium Sphaerophorus ridiculosis revealed that 24.2% of the polar lipids are the alk-1'-enyl glyceryl ether (plasmalogen) form. The major polar lipids, phosphatidylethanolamine (67.5%), phosphatidylglycerol (11.2%), cardiolipin (12.0%), and lyso-phosphatidylethanolamine (9.3%), contained 26.3, 7.8, 5.2, and 13.4% plasmalogen, respectively.


Lipoid nephrosis and focal sclerosis distinct entities or spectrum of disease.


Lipogenesis in developing guinea pig liver.


Lipophilicity and catalysis of photophosphorylation. Artificial proton translocation by lipophilic, quinoid hydrogen carriers in chloroplasts and liposomes.


Lipoprotein lipase in human adipose tissue.


Liposarcoma of the thigh: management.

Liposarcoma of the thigh: management.


Lippes Loop perforation of the uterus and urinary bladder with stone formation.


Liver abscesses in intensively fed cattle. Serial investigations of serum proteins.


Liver disease in rheumatoid arthritis.

Liver disease in rheumatoid arthritis.


Liver storage of vitamin A by rats fed carrots in various forms.


Lipolysis relation of the adipose tissue mass in obese individuals. Its modification by epinephrine.


Lobular carcinoma in situ. A long-term follow-up in 52 cases.


Lobular carcinoma in situ of the breast. Long-term followup.


Local recurrences of carcinoma of the breast.


Local excision of choroidal malignant melanoma.


Localization of coliphage MS2 A-protein. The purification of coliphage MS2 dinitrophenol (DNP) conjugates provided a system for localization of the single molecule of A-protein in the capsid of the MS2 phage particle. Three A-protein preparations isolated from unconjugated MS2, overconjugated DNP-MS2, and purified 78S DNP-MS2 were tested for the presence of covalently bound DNP. The binding characteristics to Dowex 1-X8 and rabbit anti-DNP bovine serum albumin (DNP-BSA) immunoglobulin G of the 78S DNP-MS2 and overconjugated DNP-MS2 A-protein preparations indicate that the A-protein is located on the surface of the phage particle where it can be covalently conjugated with hapten. Extensive enzymatic iodination of the A-protein of intact unconjugated MS2 substantiates this conclusion.


Localization of products of endogenous proteolysis in lysosomes of perfused rat liver.


Localization of 3H-benzpyrene in the cells of Xenopus laevis embryos.


Long bone fractures among children in Malaysia.


Long term toxicity study with alcohol and 4-methylpyrazole in rat.


Long-term evaluation of tissue valves.

Long-term evaluation of tissue valves.


Long-term follow-up of dogs, with a patent anastomosis of the thoracic duct to the esophagus.


Long-term follow-up of patients with tetralogy of Fallot: physical health and psychopathology.


Long-term lithium administration to rats. Lithium and sodium dosage and administration, avoidance of intoxication, polyuric control rats.


Long-term free-ranging recording using data integral to pulse frequency signal transformation.


Long-term mortality study of stellworkers. VII. Mortality patterns among crane operators.


Long-term prognosis of patients with central cerebral ventricular enlargement. A fourth follow-up study of 100 patients with a 3rd ventricle measuring 12 mm or more in width.


Long-term regulation of sucrose intake by the female mosquito, Aedes taeniorhynchius.


Long-term survival of patients with permanent implanted cardiac pacemaker.


Loss and recovery processes operative at the level of the cochlear microphonic during intermittent stimulation.


Loudness discomfort level under earphone and in the free field: the effects of calibration methods.


Low-dosage clomiphene therapy in the treatment of infertility due to defective ovulation.


Low-velocity gunshot wounds of the hand.


Lowering of kininogen in rat blood by adrenaline and its inhibition by sympatholytic agents, heparin and aspirin. 1 (-)-Adrenaline lowered the kininogen content and transitorily elevated the fibrinolytic activity of plasma following intravenous injection into the rat. Its effect on kininogen increased when administered by intravenous infusion.2 Although less effective, (-)-noradrenaline had a similar action to adrenaline; (+/-)-isoprenaline was inactive and failed to inhibit the effect of adrenaline.3 The effect of adrenaline on kininogen could be reproduced in vitro by incubation of whole blood, but not cell-free plasma, with the catecholamine for 5 min at 37 degrees C.4 Propranolol or phenoxybenzamine, as well as heparin or acetylsalicylic acid (aspirin), blocked the reduction of rat blood kininogen by adrenaline in vivo and in vitro.


Luminance thresholds for perceived movement in a flickering field.


Luminescence properties of sulfonamide drugs.


Looking at children in emergent family styles.


Lunar-day variations in spontaneous activity of the Mongolian gerbil.


Lymphangiographic findings in patients with leg oedema after arterial reconstructions.


Lymphangiomatous omental cyst. Report of a case.


Lymphatic transport of enzymes after experimental myocardial infarction.


Lymphocyte level and blastic transformation in splenectomized lymphoma patients.


Lymphocyte blastic transformation and DNCB response after thymectomy in man.


Lymphography in mediastinal lymph node hyperplasia. Report of two cases.


Lymphocytoma cutis.

Lymphocytoma cutis.


Lymphoid organ development in Xenopus thymectomized at eight days of age.


Lymphoid polyposis associated with familial polyposis and Gardner's syndrome. This report describes a family with familial polyposis and lymphoid polyps in which a single member exhibits features of Gardner's Syndrome. A review of the literature pertaining to the simultaneous occurrence of lymphoid polyposis with Gardner's Syndrome and familial polyposis is presented. The importance of histologic diagnosis is stressed.


Lysine inhibition of in vivo homocitrate synthesis in Penicillium chrysogenum.


Lysosomal enzyme levels in human amniotic fluid cells in tissue culture. 3. Beta-glucuronidase, N-acetyl-beta-D-glucosaminidase, alpha-mannosidase and acid phosphatase.


Lysosomal enzyme levels in human amniotic fluid cells in tissue culture. II. Alpha-galactosidase, beta-galactosidase and alpha-arabinosidase.


Lysosomes and lysosomal enzyme activity in the regenerating planarian; evidence in support of dedifferentiation.


Lysosomal stability of different tissues under nutritional stress.


Macroelectrodic activity of the facial nucleus of the cat. Bipolar stainless steel electrodes were implanted in the facial nucleus. Animals were stimulated with clicks, flashes and electric discharges applied over several points of the skin. The interaction among these modalities was presented before or after electrical stimulation of the cortex. All these stimuli produced evoked potentials in the facial nucleus. These were characterized by a biphasic potential of short latency (5 ms) and small amplitude (20-40 microvolts), followed by a negative monophasic deflection (latency of 35-40 ms and amplitude of 150-250 microvolts). This responses varied partially depending upon the modality of stimulation and the position of the facial nucleus electrode. Precollicular transection and ablation of the sigmoidean gyrus resulted in a marked reduction of the negative wave; while the initial deflection was not affected. It is concluded that the facial nucleus plays a role in the auditory localization and orienting reactions of the animal.


Magnesium absorption by the rat ileum and colon.


Magnesium effects on ionic exchange and mechanical function in rat ventricle.


Magnesium loading in potassium-adapted rats.


Making use of home care services.

Making use of home care services.


Major polar lipids of hepatitis B antigen preparations: evidence for the presence of a glycosphingolipid. The major phospholipids of hepatitis B antigen, subtype adw, were characterized as phosphatidylcholine, sphingomyelin, and lysophosphatidylcholine. In addition, two carbohydrate-containing lipids were observed, one of which was characterized as a non-sialic acid-containing, water-soluble glycosphingolipid. Upon hydrolysis the glycosphingolipid yielded both hydroxy and non-hydroxy fatty acid as well as a long-chain base which was putatively identified as dihydrosphingosine.


Malabsorption of folic acid following partial gastrectomy.


Malabsorption in overland travellers to India. Thirty-four cases of malabsorption are described in young adults after brief periods of overland travel to India. Symptoms included diarrhoea, abdominal distension, and weight loss. Investigation revealed fat, xylose, and vitamin B(12) malabsorption with marked morphological changes in the mucosa. Lower levels of serum folate and vitamin B(12) were observed in those with protracted diarrhoea, but no anaemia developed. Malabsorption may persist for many months after return to the U.K. Most patients responded initially to antibiotics, but some subsequently relapsed. The reasons why these patients developed tropical sprue are discussed.


Malabsorption of thiamin in folate-deficient rats.


Male admissions to Broadmoor hospital.

Male admissions to Broadmoor hospital.


Male copulatory behavior induced in female rats by peripheral electric shock.


Male to female ratios for Bobwhite quail breeders.


Malformations induced in offspring of crowded and parabiotically stressed mice.


Malignant external otitis.

Malignant external otitis.


Malignant melanoblastosis of the leptomeninx.


Malignant reticuloendothelial disease involving the ovary as a primary manifestation: a series of 19 lymphomas and 1 granulocytic sarcoma.


Malignant retroperitoneal hemangio-pericytoma with associated hypoglycemia. Treatment via radiotherapy.


Mammary blood flow and venous drainage in cows.


Malpractice and the dermatologist.

Malpractice and the dermatologist.


Malignant tumors of the renal urothelium.


Management of a single seizure in adolescents and adults.


Malyl coenzyme A lyase. Mechanism of action as deduced by kinetic analysis.


Management of acute hypertensive crises with clonidine (Catapres).


Management of squint in childhood.

Management of squint in childhood.


Management of scorpion sting in children.


Management of newborn babies in whom serious metabolic illness is anticipated.


Managing the maintenance of medical devices and systems.


Management of uremic pericarditis with tamponade.


Managing the urinary catheter.

Managing the urinary catheter.


Manipulative tactics of narcotics addicts.


Manifest anxiety and nail-biting.

Manifest anxiety and nail-biting.


Maridomycin, a new macrolide antibiotic. VII. Incorporation of labeled precursors into maridomycin and preparation of 14C-labeled 9-propionylmaridomycin.


Marijuana.

Marijuana.


Maridomycin, a new macrolide antibiotic. 8. Isolation and structures of metabolites of 9-propionylmaridomycin.


Marital interaction in agoraphobia.

Marital interaction in agoraphobia.


Masking patterns in band-rejected noise.


Masculinization of rat liver enzyme activities following hypophysectomy.


Mass screening for cervical carcinoma in Finland. Organization and effect on morbidity and mortality.


Mass spectrometry of the silver nitrate derivatives of cyclopropenoid compounds.


Maternal exercise as a screening test for uteroplacental insufficiency.


Maternal and fetal plasma prostaglandin levels at vaginal delivery and cesarean section.


Maternal histidinaemia.

Maternal histidinaemia.


Maternal mortality in Mississippi: 1970-1971.


Mathematical analysis of metabolic networks.


Mating in castrated male rats during combined treatment with estradiol benzoate and fluoxymesterone.


May-Hegglin anomaly: a defect in megakaryocyte fragmentation?


Mayer waves in the circulation of a teleost fish.


Measles susceptibility in two Pacific atoll populations. Epidemiological factors and response to live attenuated measles virus.


Measure for measure.

Measure for measure.


Measurement of middle ear pressure in guinea pigs.


Measurement of maximal calf flow in occlusive arterial disease of lower extremities.


Measurement of pressure in the lower esophageal sphincter. The influence of catheter diameter.


Measurement of side effects of drugs.

Measurement of side effects of drugs. In a clinical trial of two antirheumatic agents two methods of collection of side effects were used, one with and the other without a check list of possible symptoms. Findings suggested that the use of a check list interfered with the collection of side effects. Known side effects of aspirin-tinnitus, deafness, and gastrointestinal disturbance-were more efficiently shown and symptoms not included in the check list were more likely to be reported when a check list was not used.


Measurement of small mammal metabolism by infrared gas analysis.


Measurement of pregnancy-associated plasma proteins during human gestation. Studies of four pregnancy-associated plasma proteins (PAPP's) were made on 206 plasma samples obtained from 175 pregnant women between 12 and 44 wk of gestation. The concentration of three PAPP's (A, C, and D) were assayed by quantitative crossed immunoelectrophoresis. They showed a gradual but small rate of increase during the 2nd trimester, which became more rapid in the 3rd trimester. PAPP-A continued to rise steadily during this period, while PAPP-C and PAPP-D (recently identified as human placental lactogen) tended to reach a plateau. Although PAPP-B could not be quantitated because of technical problems, it was detected in over 50% of the samples from the last 2 mo of gestation, but was almost never seen in those obtained during the 12th-28th wk of gestation. Various parameters were analyzed to determine their possible correlation with the PAPP levels during the last month of gestation. The race and age of the mother showed no influence on any of the PAPP's, while parity, sex of fetus, and infant birth weights appeared to affect the plasma concentration of some of the PAPP's. In the two instances studied, mothers of twins showed abnormally high PAPP levels.


Measurement of the distance from the ureteral orifice to the bladder neck: additional objective data in the cystoscopy of patients with reflux.


Measuring the pO2 time behaviour in tumours as a valuable tool in cancer therapy.


Measurements and comparisons of lower esophageal sphincter pressures and serum gastrin levels in patients with gastroesophageal reflux.


Mechanical aspects on transureteral extraction of ureteral stones.


Mechanism of action of enzymes catalyzing thiol-disulfide interchange. Thioltransferases rather than transhydrogenases.


Mechanism of action of coumarins. Significance of vitamin K epoxide.


Mechanism of adrenal catecholamine release by divalent mercury.


Mechanism of competence in the transformation of streptococci of serological group H. The role of the competence factor and the factor inactivating transforming DNA in vitro in DNA uptake.


Mechanism of interaction of tolbutamide and phenylbutazone in diabetic patients.


Mechanism of erythropoietin production by cobaltous chloride.


Mechanism of psychogenic asthmatic attack in children.


Mechanism of ulcerogenic activity of reserpine in albino rats.


Mechanisms and biochemistry of headache.


Mechanisms for the elimination of 5-hydroxyindoleacetic acid from brain and cerebrospinal fluid of the rat during postnatal development.


Mechanisms of active transport in isolated bacterial membrane vesicles. Further studies on amino acid transport in Staphylococcus aureus membrane vesicles.


Mechanisms of hyperglycemic response to chlorpromazine administered into lateral ventricle in rats. I. Possible role of dopaminergic nervous system.


Mechanisms of hyperglycemic response to chlorpromazine administered into lateral ventricle in rats. II. Secretion of epinephrine from adrenal medulla.


Medical deontology in the Soviet Union.

Medical deontology in the Soviet Union.


Mechanisms of seizures and coma in hypoglycemia. Evidence for a direct effect of insulin on electrolyte transport in brain. The mechanisms involved in the production of hypoglycemic coma were studied in rabbits. Measurements were made in brain, cerebrospinal fluid (CSF), and plasma of osmolality, Na(+), K(+), Cl(-), water content, exogenous insulin, glucose, lactate, and glutamate, while pH, Pco(2), Po(2), and bicarbonate were evaluated in arterial blood, 35 min after i.v. injection of insulin (50 U/kg), plasma glucose did not change, but brain K(+) content increased significantly. Grand mal seizures were observed in unanesthetized animals (+/-SD) 133+/-37 min after administration of insulin, at a time when brain glucose was normal, but brain tissue content of Na(+), K(+), osmoles, and water was significantly greater than normal. Coma supervened 212+/-54 min after insulin injection, at which time brain glucose, lactate, and glutamate were significantly decreased. At both 35 and 146 min after insulin administration, exogenous insulin was present in brain, but not in the CSF. After 208 min of insulin administration, animals were given i.v. glucose and sacrificed 35 min later. Most changes in the brain produced by hypoglycemia were reversed by the administration of glucose. Hypoxia (Po(2) = 23 mm Hg) was produced and maintained for 35 min in another group of animals. Hypoxia caused brain edema but did not affect brain electrolyte content. However, brain lactate concentration was significantly greater than normal. The data indicate that the seizures noted early in the course of insulin-induced hypoglycemia are temporally related to a rise in brain osmolality secondary to an increased net transport into brain of Na(+) and K(+), probably caused by insulin, per se. As hypoglycemia persists, there is also depletion of energy-supplying substrates (glucose, lactate, glutamate) in the brain, an event which coincides with the onset of coma. The brain edema observed during hypoxia is largely due to an increase in brain osmolality secondary to accumulation of lactate.


Medical device safety and legislation: résumé of progress in the United States.


Medical education for tomorrow.

Medical education for tomorrow.


Medical experimentation on captive populations in the United States.


Medical grand rounds--from the Medical College of Virginia. Diagnosis of hemoglobinopathies.


Mediating the trauma of serious illness and hospitalization in childhood.


Medical practice, medical education, and the law.


Medical College Admission Test.

Medical College Admission Test.


Medical responsibility in operations fatalities--a review of 1313 deaths.


Medical Grand Rounds--From the Medical College of Virginia. Hypertensive encephalopathy. Recent developments in pathogenesis as related to treatment.


Medicine and the law. State Board of Insurance HMO regulations ruled invalid.


Medical devices and United States foreign policy.


Melanin. I. Kinetics of the oxidative cyclization of dopa to dopachrome.


Megaloglycolipids--unusually complex glycosphingolipids of human erythrocyte membrane with A, B, H and I blood group specificity.


Melanocyte-stimulating hormone (MSH) and overtraining effects on extradimensional shift (EDS) learning.


Melting entropy and structure of aliphatic chains in mono and bilayers.


Medical instrumentation is for people.

Medical instrumentation is for people.


Membrane properties underlying spontaneous activity of denervated muscle fibres. We have examined the events underlying the initiation of spontaneous action potentials (fibrillation) in fibres of previously denervated rat diaphragm maintained in organ culture for up to 10 days.1. Based on discharge pattern, two classes of spontaneously active fibres were found: rhythmically discharging fibres, and fibres in which action potentials occur at irregular intervals.2. Sites of action potentials initiation were located by exploration along the fibre length with two independent extracellular recording electrodes. The majority of sites of origin in both regular and irregular fibres were at the former end-plate zone; however, there was no region along the length that could not, at least in some fibres, be a site of origin.3. Intracellular recording at or near sites of origin of action potential discharge showed two types of initiating events. Irregularly discharging fibres were brought to threshold by discrete depolarizations of up to 15 mV in amplitude, while regularly occurring action potentials were associated with oscillations of the membrane potential.4. Discrete depolarizations (called fibrillatory origin potentials or f.o.p.s) at sites of origin in irregularly discharging fibres have the following properties: (a) random occurrence and nearly constant amplitude outside a refractory period during which both amplitude and probability of a second f.o.p. are reduced; (b) associated inward current flow which is localized to about 100 mum or less along the fibre length, and (c) dependence of amplitude and frequency on membrane potential.5. Oscillation of membrane potential found at sites of origin of action potential discharge in regular fibres also occurred locally along the fibre length and was sensitive to changes in membrane potential.6. Both f.o.p.s and oscillations of membrane potential were reversibly abolished by low Na(+)-Ringer fluid or tetrodotoxin.7. Neither type of initiating event was appreciably affected by concentrations of D-tubocurarine which blocked extrajunctional sensitivity to acetylcholine.8. We conclude that spontaneous action potentials under these conditions arise from a localized Na(+)-conductance change in the membrane of the active fibre; this conductance change is distinct from the increased Na(+)-conductance which follows the interaction of acetylcholine with its receptor. Spontaneous activity in single, denervated muscle fibres is cyclical and self-inhibiting (Purves & Sakmann, 1974); thus the Na(+)-conductance change underlying the initiation of spontaneous action potentials is affected by muscle fibre activity.


Membrane proteins of rat brain: compositional changes during postnatal development.


Membranes of mammary gland. IX. Concentration of glycosphingolipid galactosyl and sialytransferases in Golgi apparatus from bovine mammary gland.


Menkes kinky hair syndrome in a black infant.


Memory. Autopsy findings and comments on the role of hippocampus in experiential recall.


Mental handicap and sudden infantile hemiplegia.


Meeting the affective needs of young children.


Mental illness or metal illness? Bismuth subgallate.


Mercuric mercury and methylmercury complexes of glutathione.


Mercury binding in the kidney and liver of rats repeatedly exposed to mercuric chloride: induction of metallothionein by mercury and cadmium.


Mental retardation, megaloblastic anaemia, methylmalonic aciduria and abnormal homocysteine metabolism due to an error in vitamin B12 metabolism.


Mercury determinations in natural waters by persulfate oxidation.


Metabolic acidosis accompanying potassium deprivation.


Metabolic bone disease. Discussion.

Metabolic bone disease. Discussion.


Metabolic alkalosis in obstructive vomiting. Volume depletion and balance of net acid.


Metabolic bone diseases and chronic liver disease.


Metabolic changes due to experimentally induced rupture of the canine urinary bladder.


Metabolic epidemiology of colorectal cancer.


Metabolic consequences of a block in the synthesis of 5-keto-D-fructose in a mutant of Gluconobacter cerinus. A mutant of Gluconobacter cerinus var. ammoniacus, IFO 3267, has been isolated which is deficient with respect to fructose 5-dehydrogenase, the enzyme catalyzing the oxidation of d-fructose to 5-keto-d-fructose (5 KF). Growth of this mutant on fructose as the sole carbon source was impaired unless the culture medium was supplemented with 5 KF. Significant randomization of the 1 and 6 positions of fructose has been reported previously for the wild-type organism during growth on this ketohexose. The pattern of (3)H incorporation into the C5 position of ribonucleic acid-ribose when the mutant was grown on [1-(3)H]fructose and [6-(3)H]fructose in the presence of 5 KF indicated that such randomization did not occur in this variant. The randomization observed in the wild type is, therefore, a consequence of the partial oxidation of fructose to the symmetrical 5 KF intermediate prior to its conversion to pentose. When the mutant was grown on [1-(3)H]fructose in the presence of unlabeled 5 KF, [5-(3)H]fructose appeared in the culture medium. Thus, 5 KF served as the oxidant for the nicotinamide adenine dinucleotide phosphate, reduced form, generated during growth on fructose.


Metabolic responses to hyperpyrexia.

Metabolic responses to hyperpyrexia.


Metabolic patterns and insulin responsiveness of enlarging fat cells. The rate and pattern of glucose metabolism, basal lipolysis, and intracellular concentration of free fatty acids were determined in isolated epididymal fat cell preparations (mean volume 30-800 pl) from rats on the basis of fat cell number and in relation to the cell volume. The effects of increasing glucose concentrations in the medium and of insulin on the cellular metabolic activities were compared. Expanding fat cell volume correlated positively and significantly (P < 0.001) with the synthesis of glyceride glycerol from glucose (correlation coefficient, r = 0.919), with rates of basal lipolysis (r = 0.663), and with intracellular free fatty acid accumulation (r = 0.796); it correlated negatively and significantly with glucose conversion to glyceride fatty acids (r = -0.814, P < 0.01). The differences in patterns of glucose metabolism and basal lipolysis between small (<100 pl) and large (>400 pl) fat cells were not modified by insulin or by increments in glucose concentration. The results indicate that the reduced capacity of the large fat cells to respond to insulin cannot be attributed solely to a limited capacity of the cells to take up and metabolize increasing amounts of glucose. The acquired unresponsiveness of the large cells to insulin may result from an alteration in the mechanism of action of insulin and may be related to an intracellular metabolic derangement with increased basal lipolysis, free fatty acid accumulation, and accelerated glyceride synthesis resulting from the accumulation of triglyceride.


Metabolic studies on red cells from patients with chronic renal disease on haemodialysis.


Metabolic studies on the erythrocyte from patients with chronic renal disease on haemodialysis. II. ATP metabolism.


Metabolism and effects of androgens in hamster flank organs.


Metabolism and excretion of nitrogen during metamorphosis and egg production in the sawfly, Neodiprion sertifer.


Metabolic conditioning and metabolic actuation: experimental approaches to cancer chemotherapy involving combinations of metabolites and antimetabolites.


Metabolism of epidermal tissues, mesophyll cells, and bundle sheath strands resolved from mature nutsedge leaves.


Metabolism of a myelin-associated glycoprotein in developing rat brain.


Metabolism of ethionine by rats fed a diet deficient in choline.


Metabolism of gamma-aminobutyric acid (GABA) by peripheral nervous tissue.


Metabolism of human monoclonal immunoglobulin D. A study in two patients with monoclonal IgD gammapathy.


Metabolism of one carbon compounds: cytochromes of methane-and methanol-utilising bacteria.


Metabolism of oxygen, glucose, lactate and pyruvate in the rat brain in situ.


Metabolism of p-aminohippurate and its relevance in man.


Metaphase spread detection and focus using closed circuit television.


Methadone dose and emotional states in drug-addicted patients.


Methadone--a cause of death.

Methadone--a cause of death.


Metastatic carcinoid to the liver treated by hepatic dearterialization. A historical review of work bearing on the rationale for hepatic artery ligation in the treatment of malignant disease in the liver is presented, particularly the early work showing that malignant disease of the liver is supplied primarily by the arterial circulation and not by the portal. A review is presented of some clinical reports dealing with the effectiveness of this approach and our own limited experience with three cases presented briefly. The major emphasis is placed on the metabolic, arteriographic, microscopic and clinical studies on one patient with the carcinoid syndrome who was followed carefully over several years, treated initially by hepatic resection, later by chemotherapy and finally by hepatic dearterialization as the tumor re-grew and the carcinoid syndrome again became incapacitating. Clinical remissions was documented by changes in the excretion of 5-hydroxyindole- acetic acid and by comparison between pre- and post-op arteriography and by microscopic sections taken at re-exploration for drainage of a necrotic area in the liver.


Methallibure studies on Tilapia. II. Effect of Tilapia pituitary homogenate (TPH), human chorionic gonadotropin (HCG) and testosterone propionate (TP) on the testes of methallibure-treated Tilapia nigra.


Methanol poisoning: management of acidosis with combined haemodialysis and peritoneal dialysis.


Method for the aseptic filling of unit dose syringes.


Method for preparing bovine serum for use in cell culture media.


Methodological problems in mental illness epidemiology.


Methods of urinary diversion.

Methods of urinary diversion.


Methodology of the quantitative cytochemical analysis of single or small numbers of cultured cells.


Methotrexate induced liver disease in psoriasis.


Methylation of the guanine bases of transfer RNA.


Methylphenidate blood plasma levels in the horse determined by derivative gas-liquid chromatography--electron capture.


Metomidate anaesthesia of some birds of prey for laparotomy and sexing.


Micellar properties of drugs: determination of molecular weight, size, and molecular interactions of drug micelles using the analytical ultracentrifuge.


Micellar properties of drugs: micellar and nonmicellar patterns of self-association of hydrophobic solutes of different molecular structures--monomer fraction, availability, and misuses of micellar hypothesis.


Micellar properties of drugs: properties of micellar aggregates of phenothiazines and their aqueous solutions.


Microbial assimilation of methanol induction and function of catalase in Candida boidinii.


Microbial conversion of antibiotics. 3. Hydroxylation of maridomycin I and josamycin.


Microcauterization in otolaryngology.

Microcauterization in otolaryngology.


Microdetermination of manganese in airborne particulate samples by means of the ring-oven technique.


Microbial decontamination of parathion and p-nitrophenol in aqueous media. A mixed microbial culture was adapted to growth on parathion to determine the feasibility of using microorganisms to detoxify concentrated parathion in agricultural wastes. In a 600-ml chemostat, the culture was able to degrade 50 mg of parathion per liter per h. Para-nitrophenol, produced by enzymatic hydrolysis of parathion, caused delays in exponential growth which were directly proportional to its concentration. A pseudomonad, isolated from the mixed culture, exhibited optimal growth at 0.21 mM p-nitrophenol and grew in concentrations up to 3.5 mM. In metabolic studies using [(14)C]p-nitrophenol, the nitro group was removed in stoichiometric quantities as nitrite and hydroquinone was tentatively identified as a metabolite.


Microenvironment of histidine 12 in ribonuclease-S as detected by 13C nuclear magnetic resonance.


Microfilariae of Onchocerca volvulus in blood and urine before, during, and after treatment with diethylcarbamazine.


Microscopically controlled excision of skin tumors.


Microtomy equipment-the present situation.


Microviscosity in the surface membrane lipid layer of intact normal lymphocytes and leukemic cells.


Midline vocal cord fixation in the newborn. A new syndrome.


Migraine in patients with cluster headache.


Migraine. Diagnostic and therapeutic aspects.


Migration and health: adaptation experiences of Iranian migrants to the city of Teheran.


Mikulicz's syndrome with persistent hyposthenuria.


Migration of the monarch butterfly, Danaus plexippus: energy sources,.


Miliary Crohn's disease.

Miliary Crohn's disease.


Milroy's disease, thrombocytosis, and strokes.


Ministry to presence: the hospital and the spirit.


Minocycline in single dose therapy in the treatment of gonococcal urethritis in male patients.


Mitotic cell studies based on in vivo observations. VII. The intrinsic nature of cancer cells and of carcinogenesis as interpreted from the viewpoint in reference to cell biology.


Mitochondrial protein synthesis in aerobic and micro-aerobic continuous cultures of Candida parapsilosis.


Mitotic cycle time in perennial and annual plants with various amounts of DNA and heterochromatin.


Mitral valve motion in atrial tachycardia with block.


Mixing of additives in glass and plastic intravenous fluid containers.


Model of brain rhythmic activity. The alpha-rhythm of the thalamus.


Modern concepts of rehabilitation in the Three Services.


Modification of food to control fat intake.


Modifications of the in vitro metabolism of the hepatotoxic pyrrolizidine alkaloid, monocrotaline.