Locating interrupted hydrogen bonding in the secondary structure of PM2 circular DNA by comparative denaturation mapping. Previous studies with HCHO have revealed a reaction with superhelical DNA that strongly suggests that this DNA consists of small regions of interrupted secondary structure. To map these sites in PM2 DNA, the following set of experiments was performed using electron microscopy. (i) A denaturation map of nicked form II was obtained using Inman's alkaline-HCHO conditions. (ii) The superhelical form I was reacted with HCHO at 30 C until equilibrium was achieved at the interrupted sites (3.6% reactivity). The excess HCHO was removed rapidly and X-ray treatment was employed to nick these prereacted molecules. These form II molecules containing HCHO (form II HCHO) were also subjected to denaturation mapping. It would be expected that the HCHO-unpaired regions would serve as induction sites for the propagation of melting. Hence, depending on the location of the induction sites; we would anticipate either the creation of new regions of melting or a normal denaturation map shifted to lower pH values. Comparison of the development of progressive denaturation of form II and form II HCHO reveals that the latter is the case. The denaturation maps of form II are highly organized patterns of adenine-thymine (AT)-rich regions, with a total of five regions at extreme pH conditions. There are six highly organized regions for form II HCHO, i.e., smaller adjacent loops, at low denaturation conditions where no denaturation is seen for form II. These coalesce into the pattern for form II containing four of five A-T-rich regions observed for form II. Hence we conclude that the regions of altered hydrogen bonding in superhelical PM2 DNA are four to six in number and they map in the A-T-rich regions of the DNA.


Electron microscopy of viral RNA: molecular weight determination of bacterial and animal virus RNAs. A method for preparation of single-stranded RNA for electron microscopy determination of molecular weight is reported. The method uses treatment with formaldehyde at elevated temperatures to remove secondary structure and spreading in a protein monolayer from 50% formamide onto a 50% formamide hypophase. Molecular weights were determined for some bacterial and animal viruses, for which conflicting values had been reported earlier. Molecular weights determined by the method, using Escherichia coli large subunit rRNA for a standard (1.1 x 10(6)), are as follows: E. coli small subunit rRNA, 0.53 x 10(6); coliphage f2-RNA, 1.3 x 10(6); Qbeta-RNA, 1.55 x 10(6); and Newcastle disease virus RNA, 5.78 x 10(6).


Polyadenylate sequences on Newcastle disease virus mRNA synthesized in vivo and in vitro. Polyadenylate [poly(A)] sequences are associated with the 35 and 50S Newcastle disease virus (NDV)-specific RNAs as well as all six to seven of the 18-22S NDV-specific messenger RNAs extracted from infected chicken embryo cells. The poly(A) associated with the 18-22S RNA has an average size of 120 to 130 nucleotides. The 18-22S RNA synthesized in vitro by NDV's virion-bound polymerase contains six to seven species of the same size and relative proportions as its intracellular counterpart. This in vitro synthesized 18-22S RNA also contains covalently linked poly(A) sequences which, although variable in size, are usually larger and more heterogeneous than those from the infected cell. In vitro RNA synthesis is supported not only by magnesium (at an optimal concentration of mM) but by manganese (at an optimal concentration of 0.5 to 1.0 mM) as well. However, the major product made in the presence of manganese, although sedimenting at 18 to 22S, differs somewhat from the product made in the presence of magnesium.


DNA polymerase in the core of the human hepatitis B virus candidate. Experiments were done to show that the human hepatitis B antigen (HBAg)-associated DNA polymerase is a component of Dane particles and their antigenically distinct cores prepared by Nonidet P-40 detergent treatment of Dane particles. Before detergent treatment, the DNA polymerase was precipitated by serum containing anti-HB surface antigen (anti-HB(s)) but not with serum containing anti-HB core antigen (anti-HB(c)). After detergent treatment, the enzyme was precipitated by anti-HB(c)- and not by anti-HB(s)-containing serum. Highly purified 16- to 25-nm HBAg particles blocked only the precipitation of DNA polymerase in untreated HBAg preparations. The 110S structure with which the DNA reaction product remains associated in Nonidet P-40-treated preparations was identified as Dane particle core by immunoprecipitation with serum containing anti-HB(c). The DNA polymerase and the radioactive DNA reaction product were used as markers for core in immunoprecipitation tests for anticore. In such assays, 8 of 11 human sera with anti-HB(s) activity and all of 10 sera from chronic HBAg carriers were found to contain anti-HB(c) activity.


Base composition and hybridization studies of the three double-stranded RNA segments of bacteriophage phi 6. The three double-stranded ribonucleic acid (dsRNA) segments of the bacteriophage phi6 were isolated and shown to have similar melting temperatures and base compositions. RNA:RNA hybridization experiments with the isolated segments eliminate the possibility that the two smaller dsRNA segments arise from a cleavage of the large dsRNA segment. The two smaller RNA segments reanneal rapidly even at low temperatures; in contrast, the large dsRNA reannealed only at higher temperatures. Evidence is also presented which suggests that the dsRNAs may contain a short single-stranded RNA tail.


Origin of reovirus oligo(A).

Origin of reovirus oligo(A). Reovirus contains about 1,200 molecules per virion of oligo(A) of chain length 10 to 15 nucleotides in addition to the 10 double-stranded genome segments. Virions purified from infected BHK, HeLa, or L cells had similar amounts of oligo(A) of the same composition, indicating that it is a virus-specific product. Although conversion of virions to cores by chymotryptic digestion resulted in an almost complete loss of oligo(A) and a marked decrease in infectivity, the infectivity could be partially restored by adsorbing cores to cells in the presence of Kaopectate. Core-infected cells yielded virions that contained a normal complement of oligo(A). The results indicate that oligo(A) is not essential for infectivity or required as a primer/template for its own synthesis.


Poly(A) polymerase activity in reovirus. An enzymatic activity which synthesized oligo(A) in vitro was found in highly purified reovirus. The poly(A) polymerase activity was dependent on Mn(2+) and utilized only ATP, whereas the virion-associated RNA polymerase required all four ribonucleoside triphosphates and Mg(2+). Oligo(A) synthesis was demonstrated with complete virions and infectious subviral particles derived from virus by limited chymotrypsin digestion but not with cores, a product of extensive chymotrypsin digestion of virus. The enzymatic product and the oligo(A) from purified virions were isolated by binding to oligo(dT)-cellulose columns. Most of the in vitro product was similar in size and structure to the oligo(A) from purified virions by the criteria of gel electrophoresis, DEAE-cellulose chromatography, end-group analysis, and sensitivity to RNase. The evidence suggests that oligo(A) synthesis is mediated by the poly(A) polymerase during a late step in viral morphogenesis and may result from an alternative activity of the virion-associated transcriptase.


Structural aberrations in T-even bacteriophage. IV. Parameters of induction and formation of lollipops. Previous results from our laboratory have shown that when a T-even bacteriophage-infected bacterial cell was exposed to l-canavanine followed by an l-arginine chase, a monster phage particle, termed a lollipop, was formed. We now describe certain parameters concerning (i) the induction and (ii) the formation of T4 lollipops. The induction step involves a T4 late function, and can require only a 3-min exposure to l-canavanine. Short pulses of l-canavanine result in the formation of shorter lollipops indicating the presence of a possible "precursor substance" which is influenced by l-canavanine. DNA synthesis is inhibited by l-canavanine but is stimulated 20 to 40 min after the addition of l-arginine. Chloramphenicol prevents both responses indicating a possible protein involvement. The appearance of lollipops and phage was noted only after 25 min after the addition of l-arginine.


Structural aberrations in T-even bacteriophage. V. Effects of canavanine on the maturation and utilization of specific gene products. Previous results have shown that when a T-even bacteriophage-infected cell was exposed to l-canavanine followed by an exposure to l-arginine, a monster phage particle, termed a lollipop, was formed. l-Canavanine was necessary for the induction event but l-arginine was required for the maturation of the particle. We now describe the effects of canavanine on the maturation of certain T4 proteins and their role in the induction of lollipops. The cleavage reactions of the head proteins P22, P23, P24, and IPIII are prevented by l-canavanine as shown by the accumulation of the precursor proteins and the failure of the cleaved products to appear. l-Canavanine also prevents the appearance of P12 (tailplate protein) and P20 (head protein) indicating that these proteins may undergo a proteolytic cleavage during normal assembly. The formation of P10 (tailplate protein) and P18 (tail sheath protein) is also affected by l-canavanine. The data suggest that P23 in conjunction with P20 plays a major role in the determination of the length of the phage head.


Buoyant density of the hepatitis A virus-like particle in cesium chloride. We recently visualized by immune electron microscopy a virus-like particle in the stools of patients with hepatitis A. The particle measured approximately 27 nm in diameter and morphologically resembled a picornavirus or parvovirus. To further characterize this particle, we have determined its buoyant density in cesium chloride (CsCl) by ultracentrifugation. Hepatitis A particles from three positive stool specimens were isopycnically banded in separate experiments, and the gradient fractions were examined for particles by immune electron microscopy by using hepatitis A convalescent sera. In each experiment, the particles were observed in a normal distribution about a peak fraction with a mean density of approximately 1.4 g/cm(3). The buoyant density of 1.4 g/cm(3) in CsCl together with its morphology and the reported resistance of hepatitis virus to acid, ether, and heat suggest that this particle is parvovirus-like.


Sensitivity of bacteriophage Mu-1 development to rifampicin and streptolydigin.


Platelet-release reaction induced by the lectin concanavalin A.


On the precipitation of aragonite on the surface of marine bacteria.


Cytokinin formation in pea seeds.

Cytokinin formation in pea seeds.


Acrosin activity and acrosome ultrastructure of human spermatozoa after freeze preservation.


Effect of alloxan diabetes of allyl propyl disulphide obtained from onion.


Dynamics of in-vitro glucose uptake by hemidiaphragm of white rats with Walker 256 carcinosarcoma.


Working together for children: a child advocacy system.


Temperament in adopted and foster babies.


Social agency and school: training educators to deliver helping services.


A group method of engaging parents at a child psychiatry clinic.


An improved simple exercise test for evaluation of physical fitness.


Oxygen uptake calculated from expiratory volume and oxygen analysis only.


The application of stairclimbing to ergometry.


Physiological evaluations of armoured vests in hot-wet and hot-dry climates.


Energy intake and expenditure with reference to the female physical education student.


Physiological problems in repetitive lifting with special reference to tolerance limits to the maximum lifting frequency.


Physiological responses to standardised arm work.


The interaction of the loss of a night's sleep with mild heat: task variables.


Dentistry: a growing domain for ergonomics.


Visual pigments. IV. Experimental and theoretical investigations of the absorption spectra of retinal Schiff bases and retinals.


Synthetic analogs of the active sites of iron-sulfur proteins. V. Proton resonance properties of the tetranuclear clusters (Fe4S4(SR)4). Evidence for dominant contact interactions.


Copper(II) complex catalysis of amino acid ester hydrolysis. A correlation with complex stability.


Multiproton catalysis in the hydrolysis of 3,5-dinitroaspirin.


Aplysiatoxin and debromoaplysiatoxin, constituents of the marine mollusk Stylocheilus longicauda (Quoy and Gaimard, 1824).


Biosynthetic incorporation of (1-13C)glucosamine and (6-13C)glucose into neomycin.


Structure and synthesis of moniliformin, a novel cyclobutane microbial toxin.


A laboratory model for the biogenesis of the "antipodal" strychnos alkaloids.


Analysis of steroids. XXIV. A specific method for the spectrophotometric determination of 17-ethynyl steroids.


Determination of the substituted pyrimidine pesticides ethirimol, dimethirimol, pirimiphos-methyl, pirimiphos-ethyl and pirimicarb in technical and formulated materials by gas chromatography.


The determination of clopidol in animal feeds.


A hitherto undescribed pigment found in human urinary uric acid stones.


A new pyroglutamylpeptide (Pyr-Lys-Ser) isolated from the venom of Agkistrodon halys blomhoffii.


Effect of sodium chlorophenoxyisobutyrate on the binding of vitamin K antagonists to human albumin in vitro.


Lipid metabolism in suckling rats with fatty liver induced by hypoxia.


Activation and stabilization of halophilic enzymes by magnesium and calcium ions.


Lipid lowering effect of allicin (diallyl disulphide-oxide) on long term feeding to normal rats.


Cycloheximide: a specific inhibitor of protein synthesis and intercellular ion transport in plant roots.


Repetitive DNA associated with rodent liver nuclear envelopes.


The low calcium content of cellular systems adapted to flow.


Mode of action of DDT analogues: molecular orbital studies.


A study of the combined Raman and fluorescence scattering from human blood plasma.


Mutagenicity and infertility following administration of lead sub-acetate to Swiss male mice.


DNA renaturation kinetics in some paedogenetic Urodeles.


The incidence of repeated mating in the superspecies, Drosophila paulistorum.


Antagonism between plant growth regulators in pollen tube elongation of Calotropis procera.


Hemoglobin J beta Baltimore in a fourth French Canadian family.


Plasmodium juxtanucleare: an electron microscopic study of the exoerythrocytic stages.


Incorporation of viral genome in DNA of chronically infected cells.


Excitation and inhibition of hypothalamic neurons by cerebellar stimulation in rabbits.


Pheromone and host odor-stimulated potentials in Dendroctonus.


S-100 protein in cerebral cortex synaptosomes.


Water movement during diuresis in the tsetse fly (Glossina austeni).


The effect of applied tension on the length of striped muscle.


Spontaneous regeneration of the gastrocnemius muscle of the frog. Rana tigrina.


Differences in brain and body weights of mice caused by differential housing.


In vitro synthesis of metabolites of 14C-pyridostigmine.


Studies on the collectability of 3H-gamma-aminobutyric acid from rat cerebral cortex; effects of lithium.


Cadmium-induced potentiation of hexobarbital sleep time in rats.


Toxic metabolites of Aspergillus candidus.


Adsorption activated charcoal and polarity of cardenolides and bufadienolides.


Prevention by cystamine of the rat liver polysomal disaggregation induced by carbon tetrachloride (CCl4).


Effect of PGE2 on the turnover of calcium in rat uterus.


Electron microscopic observations on the olivary projections to the cerebellar nuclei in the cat.


The influence of farnesenic acid ethyl ester on the differentiation of Kalotermes flavicollis Fabr. (Isoptera) soldiers.


Relative and absolute goblet cell numbers in intestinal crypts following irradiation or actinomycin D.


Effect of hyperventilation on the platelet aggregation induced by ADP.


Effect of manganese on the ADP-induced platelet aggregation.


The effect of antidiuretic hormone on the extravascular protein in the renal medulla.


Effect of pregnenolone-16alpha-carbonitrile on mitotic activity in the intact and regenerating rat liver.


On correlation between the generation age of the fathers and grandfathers and the intelligence of the descendants.


Homogeneity of ion distribution in, and macromolecular exclusion from Sephadex G-25 beads.


Pure-tone intensity discrimination: some experiments relating to the "near-miss" to Weber's law.


Model for mechanical to neural transduction in the auditory receptor.


Pitch, consonance, and harmony.

Pitch, consonance, and harmony.


Model for wave propagation in a lossy vocal tract.


Letter: Psychoacoustic calibration of the Telex 1470 earphone.


Letter: PEST: note on the reduction of variance of threshold estimates.


Letter: Bilateral hearing asymmetry in a large population.


letter: Discrete relaxation processes as a model of the absorption of ultrasound in liver homogenate.


Letter: Discrete relaxation processes as a model of the absorption of ultrasound in liver homogenate.


Electrochemistry in media of intermediate acidity. 8. Reversible oxidation products of the alpha-tocopherol model compound. Cation radical, cation, and dication.


Synthesis and evaluation of a model for the so-called "charge-relay" system of the serine esterases.


Hydrolysis of substituted trifluoroacetanilides. Nucleophilic catalysis by imidazole.


Photocyclizations of N-chloroacetyltyramine. I. Formation of novel dimeric cage compounds.


Photocyclizations of N-chloroacetyltyramines. II. Flash photolysis and substituent effect studies on the formation of dimeric cage compounds, and novel acid-catalyzed reversion.


The crystal structure of the antitumor agent 5-(3,3-dimethyl-l-triazeno)imidazole-4-carboxamide monohydrate hydrochloride (NSC-45388).


Conformation of cyclic peptides. 8. Cyclic hexapeptides containing the L-Pro-D-Phe sequence.


Intermolecular proton transfer reaction between base and phosphate moieties of mononucleotides in solution.


Preparation and properties of iron(3)-amino acid complexes. Iron(3)-alanine, a possible ferritin analog.


Unusual metalloporphyrins. 23. Fluxional behavior of out of plane organometalloprophyrins.


A paramagnetic dioxygen complex of iron (II) derived from a "picket fence" porphyrin. Further models for hemoproteins.


Equivalence of metal centers in the iron-sulfur protein active site analogs (Fe4S4(SR)4)2-.


Coordination geometries of high-spin manganese(3) porphyrins and their synthetic intermediates.


Reaction rate of bilirubin with singlet oxygen (1delta g) and its strong enhancement by added base.


Semiempirical calculations on the electronic structure and preferred conformations of thiamine (vitamin B1) and thiamine pyrophosphate (cocarboxylase).


Letter: Properties of 14-methylretinal, 13-desmethyl-14-methylretinal, and visual pigments formed therefrom.


Letter: Paramagnetic rare earth ion probes of transfer ribonucleic acid structure.


Letter: Nucleoside complexing. A charge reversed chelate compound between guanosine and chloride ion.


Letter: Structural implication in metalloporphyrins of the 1590-cm-1 anomalously polarized resonance Raman line.


Letter: A high yield stereospecific total synthesis of vincamine.


Letter: Novel maytansinoids. Structural interrelations and requirements for antileukemic activity.


Synthesis of 2,9beta-dimethyl-6,7-benzomorphan.


A synthetic approach to aporphine alkaloids. A new tetracyclic benzodiazepine derivative from the benzyne cyclization of a bromophenolic 1-benzyltetrahydroisoquinoline.


Synthesis of macrolide antibiotics. I. Stereospecific addition of methyllithium and methylmagnesium iodide to methyl alpha-D-xylo-hexopyranosid-4-ulose derivatives. Determination of the configuration at the branching carbon atom by carbon-13 nuclear magnetic resonance spectroscopy.


C-glycosyl nucleosides. V. A novel one-step asymmetric synthesis of C-Nucleoside analogs.


Purine N-oxides. LVI. Photoisomerization of 1-hydroxy-to 3-hydroxyxanthine. Photochemistry of related 1-hydroxypurines.


Oxidation of tyrosine and of NH2-terminal tyrosine peptides with the Cu2+-H2O2 system.


Synthesis of 6-hydroxypenicillanates and 7-hydroxycephalosporanates.


Prolongation of the activated partial thromboplastin time associated with poor venipuncture technic.


Observations on diagnostic kits for the determination of plasma fibrinogen.


Coombs-negative autoimmune hemolytic anemia and immunoglobulin deficiency.


Acute megakaryocytic myelofibrosis. Case report of an unusual myeloproliferative syndrome.


A comparison of the staphylococcal clumping test and an agglutination test for detection of fibrinogen degradation products.


Laboratory suggestion. A device for producing gaseous mixtures in incubation chambers.


Letter: Systemic infection due to Actinobacillus actinomycetemcomitans.


Letter: Rheumatoid arthritis latex kits.


Rat liver daunorubicin reductase. An aldo-keto reductase.


The amino acid sequence of putidaredoxin, an iron-sulfur protein from Pseudomonas putida.


Primary structure of bovine carboxypeptidase B. Inferences from the locations of the half-cystines and identification of the active site arginine.


Effect of pH and anions on functional properties of hemoglobin from Lemur fulvus fulvus.


Bitis gabonica venom. The amino acid sequence of phospholipase A.


Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexosis. IX. Purification and properties of the cytidine diphosphate-D-glucose pyrophosphorylase from Pasteurella pseudotuberculosis. type V.


In vivo rate of translation by ribosomes of normal and regenerating liver.


Studies on the hetrogeneity of lysine-rich histones in dividing cells.


Purification and properties of acid deoxyribonucleases of human gastric mucosa and cervix uteri.


Crystallographic studies of D-xylose isomerase.


The effect of theophylline on tryptophan pyrrolase in the hypophysectomized rat and some observations on the validity of tryptophan pyrrolase assays.


Induction of enzyme secretion in rat pancreatic slices using the ionophore A-23187 and calcium. An experimental bypass of the hormone receptor pathway.


Influence of age of host on the chemotherapy of murine myeloma LCP-1.


The activity of lactate and malate dehydrogenases in the liver and testes of senescent C57BL-6 mice.


Mechanisms of hypoxemia in the elderly.

Mechanisms of hypoxemia in the elderly.


A mathematical model of aging processes. II.


Longitudinal and cross-sectional assessments of age changes in physical strength as related to sex, social class, and mental ability.


The four-day workweek and the elderly: a cross-sectional study.


Self-concept and altruism in old age.

Self-concept and altruism in old age.


Survival in relocation.

Survival in relocation.


Correlates of life satisfaction among the aged.


Proceedings: The biosynthesis of rhodopsin in vitro.


Proceedings: A role for Ca2+ in excitation of retinal rods and cones.


Proceedings: Polyunsaturated fatty acids of photoreceptor membranes.


Proceedings: The transmuted visual pigments of geckos.


Proceedings: Evolution of visual pigments.


Radiation therapy in the treatment of keloids in East Africa.


Effect of 200, 650 and 1 200 R on the intestinal disaccharases and dipeptidases.


Proceedings: Lymphocyte depressive factor produced by a gut cancer.


Proceedings: Kaposi sarcoma in African children.


Proceedings: Inhibition of experimental metastases by defibrination.


Proceedings: In vitro demonstration of the photodynamic effect on human brain tumours.


Proceedings: Feasibility of screening the population at risk from breast cancer.


Pelvic anatomy. II. Anal canal and associated sphincters.


Cyclical combination chemotherapy in advanced breast cancer.


Minilaparotomy: an integrated procedure for rapid diagnosis in postcholecystectomy biliary tract symptoms.


Breakdown of small-bowel anastomoses after pelvic radiotherapy.


The Andrew Fleming Hospital, Salisbury, Rhodesia.


Light and electron microscopic studies of physical injury to the skin. I. Suction.


Light and electron microscopic studies of physical injury to the skin. II. Friction.


The action of sodium lauryl sulphate on rat skin--an ultrastructural study.


The cell cycle in psoriasis.

The cell cycle in psoriasis.


In vitro assay of cell-mediated immunity to human wart antigen.


Photo-contact dermatitis arising from the presence of quindoxin in animal feeding stuffs.


Blood prostaglandin activity associated with noradrenaline-provoked flush in the carcinoid syndrome.


Successful surgical treatment of lipoid proteinosis.


Biological comparison of isomers and chemical forms of vitamin A(retinol).


Pustular psoriasis in association with renal amyloidosis.


Painful piezogenic pedal papules.

Painful piezogenic pedal papules.


Letter: Keratinization of subcultured keratinocytes.


Pemphigus and Hodgkin's disease.

Pemphigus and Hodgkin's disease.


Letter: Atypical scalp ringworm caused by Microsporum canis.


Letter: Nail anomalies in Hodgkin's disease.


Letter: The persistent nuchal or occipital salmon patch.


Betamethasone and betamethasone valerate.


Augmentation of lymphocyte reactivity in guinea pigs, mice, monkeys and humans sensitised to BCG, dinitrochlorobenzene or nitrogen mustard.


Submit complex 3-IV as the nucleotide binding site of Q-beta replicase.


Effect of ATP on release of intracellular enzymes from damaged cells.


Cone mechanisms initiating response of on-off goldfish optic fibres.


Involvement of brain cholinergic mechanisms in the action of chlorpromazine.


Effect of histamine H-receptor blockade on fasting serum gastrin and fasting gastric acid secretion in the dog.


Genetic variation in marine fishes as a test of the niche-variation hypothesis.


Formation of methylmercury in a terrestrial environment.


Effects of stable chlorine-containing organics on aquatic environments.


A comparison of the specific effects of oestriol and oestradiol on the uterine body and cervix of the spayed rat.


Affinity labelling studies with 109cadmium in cadmium-induced testicular injury in rats.


Leucoytes in the luminal epithelium of the mouse uterus at implantation.


Variation of the DNA content of morphologically normal and abnormal spermatozoa in mice sesceptible to irregular meiotic segregation.


Cholinesterase distribution during spermatid differentiation and spermatozoal maturation in the white mouse.


Effects of alpha-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat.


Gonadal and epididymal sperm reserves in the camel, Camelus dromedarius.


Further studies on the antitesticular activity of a pipecolinomethylhydroxyindane.


The effect of variations in culture conditions on the motility of hamster spermatozoa.


The half-life of human placental lactogen in non-immune and immune rhesus monkeys.


Maturation and fertilization in vitro of guinea-pig ovarian oocytes.


Development of hamster eggs fertilized in vitro or in vivo.


Herbicides in Vietnam.

Herbicides in Vietnam.


Physical-chemical basis of lipid deposition in atherosclerosis.


Analogy as a source of knowledge.

Analogy as a source of knowledge.


Long-lived chemiluminescence in cigarette smoke. Cigarette smooke contains high concentrations of unstable moleculles that react with oxygen to produce chemiluminescence. The chemiluminescent activity is concentrated in the aerosol phase that can be absorbed on glass-fiber filters and extracted into organic solvents. Cigarette smnoke in N, N-dimethylformamide produces a long-lasting luminescence visible to the dark-adapted eye. We have demonstrated the oxygen dependence and have measured the kinetics, activation energies, emission spectra, and absolute photon intensities of this chemiluminescence. The total light emission from a single puff (35 cubic centimeters) of cigarette smoke is greater than 10(12) photons. There was a significant correlation between smoke chemiluminescence anSd tar content. It is suggested that the chemical production of electronically excited states of aromatic hydrocarbons is equivalent to photoexcitation in the promotion of the carcinogenicity of these agents.


Microwave hearing: evidence for thermoacoustic auditory stimulation by pulsed microwaves. Acoustic transients can be thermally generated in water by pulsed microwave energy. The peak pressure level of these transients, measured within the audible frequency band as a function of the microwave pulse parameters, is adequate to explain the "clicks" heard by people exposed to microwave radiation.


Lassa virus isolation from Mastomys natalensis rodents during an epidemic in Sierra Leone. Lassa fever is a severe febrile illness of man, first recognized in West Africa in 1969. During an epidemic in Sierra Leone, Lassa virus was isolated for the first time from wild rodents of Mastomys natalensis. A high prevalence of infected Mastomys was found in houses occupied by patients with Lassa fever. The data presented provide the first demonstration of an extra-human cycle of Lassa virus transmission and suggest that rodent control may be an effective method of limiting the disease.


Microbodies (peroxisomes) containing catalase in myocardium: morphological and biochemical evidence. Microbodies characterized by a single limiting membrane and finely granular matrix occur in mouse myocardium and appear in close spatial relation to mitochondria and sarcoplasmic reticulum. The presence of catalase in the microbodies is revealed cytochemically and confirmed biochemically by direct measurement of its activity in myocardial tissue fractions. It is suggested that the microbodies may play an important role in myocardial lipid metabolism.


Noise-induced reduction of inner-ear microphonic response: dependence on body temperature. The rate of reduction of chinchilla cochlear microphonic response with exposure to steady noise is less at lower body temperatures and greater at higher body temperatures. Before exposure to noise, this auditory response is invariant within the range of temperatures employed. The mechanism of reduction of cochlear response appears to involve processes sensitive to body temperature.


Gelation of sickle cell hemoglobin: effects of hybrid tetramer formation in hemoglobin mixtures. The altered gelation behavior found in mixtures of sickle cell hemoglobin with other hemoglobins is due to the formation of hybrid hemoglobin tetramers from unlike dimers. The hemoglobins need not possess the deoxy quaternary structure for gelation to occur; liganded forms are also capable of participation in gelation.


Adrenergic innervation of the parasympathetic ciliary ganglion in the chick. The chick ciliary ganglion receives a nonvascular symathetic innervation in addition to the well-known cholinergic one; fluorescent, varicose adrenergic fibers form pericelluar baskets. Adrenergic fibes were identified electron microscopically in ganglia fixed with potassium permanganate. The fibers degenerate after injection of 6-hydroxydopamine. No true synaptic relationships involving adrenergic varicosities and ganglion cells or cholinergic terminals were demonstrable. The distribution of the adrenergic fibers suggests a kind of "distance à synapse" with the choroidal cells or with the preganglionic fibers (or both). The adrenergic innervation might provide a modulation of the cholinergic transmission.


Ethnic classification of Mexican-Americans.


Reset of osmoreceptors in association with normovolemic hyponatremia.


Red blood cell mean corpuscular volume: a potential indicator of alcohol usage in a working population.


Correlation of electrocardiographic changes and hemodynamic functions in the treatment of primary arterial hypertension.


Metabolic complications of aggressive therapy of chronic lymphocytic leukemia.


Serum enzyme activity following cardiac catheterization and endomyocardial biopsy.


Experimental lead cardiomyopathy: myocardial structural changes in rats given small amounts of lead.


Studies on the mechanism of interaction between lysergic acid and chromosomes.


Arylsulfatase A deficiency in bone marrow fibroblasts of two different forms of metachromatic leukodystrophy.


Radiosensitivity of human endothelial cells in culture.


Acid lipase in cultured fibroblasts: cholesterol ester storage disease.


Factor XIII consumption as an indicator of thrombin generation.


Extracorporeal treatment of blood with cyanate in primates: physiologic and toxicologic observations.


Bone marrow delta-aminolevulinic acid synthetase activity in experimental sideroblastic anemia.


A role of the kidney in the catabolism of erythropoietin in the rat.


Measurement of red cell destruction in the spleen.


Separation of erythrocytes according to age on a simplified density gradient.


Eimeria phocae sp. n. from the harbor seal (Phoca vitulina concolor).


Eimeria glauceae sp. n. and Eimeria dusii sp. n. (Protozoa: Eimeriidae) from the eastern woodrat, Neotoma floridana, from Alabama.


Protomonascus nybelini Thulin, 1973, a synonym for Elopsium ghanense Fischthal and Thomas, 1972.


Alloglossidium macrobdellensis sp. n. (Trematoda: Macroderoididae) from the leech, Macrobdella ditetra Moore, 1953.


The site of action of a broad-spectrum aryltriazine anticoccidial, CP-25,415.


Successful jird-to-jird transfer of juvenile Brugia pahangi.


The cystic stage of Octomyomermis itascensis (Nematoda: Mermithidae) in Chironomus plumosus (L.) (Diptera).


The nervous system of larval Schistosoma mansoni as revealed by acetylcholinesterase staining.


Ectoparasites of the plain chachalaca, Ortalis vetula mccalli, from south Texas.


Haemaphysalis (Elongiphysalis) elongata Neumann subgen. n. (Ixodoidea: Ixodidae): structural variation, hosts, and distribution in Madagascar.


Reproduction in ticks (Acari: Ixodoidea). 3. Copulation in Dermacentor occidentalis Marx and Haemaphysalis leporispalustris (Packard) (Ixodidae).


Helminths of the short-tailed shrew, Blarina brevicauda, in North Carolina.


Types of growth of Trichomonas gallinae in a maltose medium.


Anticoccidial activity of rosamicin.

Anticoccidial activity of rosamicin.


Isolation of schizonts and merozoites of Eimeria callospermophili from cultured bovine intestinal cells.


First record of Hemiurus levinseni Odhner (Trematoda:Hemiuridae) in haddock in the western North Atlantic Ocean.


Branched Schistosoma mansoni daughter sporocysts.


Mature Paragonimus amazonicus first found from a water opossum in Peru.


The effect of administration of known fasciolicides in the diet to rats infected with Fasciola hepatica.


Some biological characteristics of Liberian and Puerto Rican strains of Schistosoma mansoni.


Chromosome analysis of Mesocestoides corti (Cestoda).


An efficient technique for exposure of rodents to Schistosoma mansoni or S. haematobium.


Conjunctivodacryocystostomy.

Conjunctivodacryocystostomy.


A new form of albinism.

A new form of albinism.


Phacocryolysis combined with phacofragmentation and irrigation for removal of cataracts.


Ocular involvement in chondrodysplasia punctata.


Oculopharyngeal muscular dystrophy.

Oculopharyngeal muscular dystrophy.


Kleinfelter's syndrome with anophthalmos.


The ultrastructure of orbital fibrosarcoma.


Pilocarpine adsorption by serum and ocular tissues.


Letter: Blood-aqueous barrier.

Letter: Blood-aqueous barrier.


Letter: Congenital corneal leukomas.

Letter: Congenital corneal leukomas.


Review of roentgenographic bone demineralization studies of the Gemini space flights.


Cleidocranial dysostosis. A review of 40 new cases.


Condensing osteitis of the clavicle: a new entity.


Similar bone manifestations of scleroderma and rheumatoid arthritis.


Diabetic osteoarthropathy. Clinical and roentgenographic observations in 90 cases.


Homocystinuria due to cystathionine synthase deficiency: clinical-roentgenologic correlations.


Complications of total hip replacement. A roentgen evaluation.


The painful Charnley total hip replacement.


Arthrography in rupture of the suprapatellar bursa with pseudocyst formation.


"Clipping injury" fracture of the epiphysis in the adolescent football player: an occult lesion of the knee.


Use of xeroradiography in cruciate ligament injuries.


Lipohemarthrosis.

Lipohemarthrosis.


The distal anterior femoral metaphyseal defect: an anatomic variant that may simulate disease.


Multifocal osteoid osteoma. A case report and review of the literature.


Calcification in Cooper's ligament.

Calcification in Cooper's ligament.


Extravasation of calcium gluconate as a cause of soft tissue calcification in infancy.


Primary lymphangioma of the calvarium.

Primary lymphangioma of the calvarium.


Multiple calvarial "doughnut lesions".

Multiple calvarial "doughnut lesions".


The maxillary artery in craniofacial pathology.


Os supra petrosum of Meckel.

Os supra petrosum of Meckel.


Patterns of injury and significance of uncommon fractures in the battered child syndrome.


Pharmacologic aids in angiography of the upper extremity.


Size of pelvic bony outlet in renal agenesis.


Technetium 99m labeled diphosphonate bone scanning in Paget's disease.


Neonatal transplacental rubella syndrome. Its effect on normal maturation of the diaphysis.


Comparison of Tc99m polyphosphate and F18 for bone imaging.


Editorial: Continuing medical education. Implications concerning recertification, re-examination and relicensure.


Studies on the role of stimulated epidermal DNA synthesis in the initiation of skin tumors in mice by N-methyl-N'-nitro-N-nitrosoguanidine.


Inhibition of the effects of methylcholanthrene on mouse prostate in organ culture by vitamin A and its analogs.


Influence of antileukemic (L1210) treatment schedule on disposition of (minus)-emetine hydrochloride (NSC 33669) in normal and leukemic mice.


Cardiac and pulmonary effects of high doses of cyclophosphamide and isophosphamide.


DNA damage and its repair in transformable mouse fibroblasts treated with N-methyl-N'-nitro-N-nitrosoguanidine.


Cell cycle dependency of DNA damage and repair in transformable mouse fibroblasts treated with N-methyl-N'--nitro-N-nitrosoguanidine.


Chemotherapeutic, carcinogenic, and cell-regulatory effects of triazenes.


Interaction of thymidylate synthetase and dihydrofolate reductase enzymes in vitro and in vivo.


Therapy with allogeneic immune peritoneal cells.


Chemotherapy and rate of kill of tumor cells in a mouse plasmacytoma.


Budget and The National Cancer Program (NCP).


Protective effect of immunization with polyinosinic-polycytidylic acid complexed with methylated bovine serum albumin against Friend leukemia virus in mice.


Letter: Biological contaminants and scientific misinterpretations.


Editorial: Rational use of theophylline for bronchodilatation.


Letter: Ventricular defibrillators in heavy patients.


Letter: Sinoventricular conduction with absent P waves.


Letter: Hereditary ataxia and HL-A genotypes.


Letter: Extension of two-part consent form.


Effect of contrast agents on platelet aggregation and 14C-serotonin release.


Letter: Soviet Jewish physicians.

Letter: Soviet Jewish physicians.


Letter: Reassurance about Russian giardiasis.


The chondrocalcific arthropathy of iron overload. Relationship to hemochromatosis.


Hypouricemia. An incidental finding indicating xanthinuria or defective reabsorption of uric acid.


Serum enzyme values following intramuscular administration of lidocaine.


Radioimmunoassay of carcinoembryonic antigen. A diagnostic test for carcinoma of the colon and pancreas.


Outpatient gym exercise program for patients with recent myocardial infarction. A preliminary report.


Clindamycin in the oral treatment of putative anaerobic pneumonias.


Parenteral clindamycin therapy for severe anaerobic infections.


A medical information system for the coronary care unit.


Postpolycythemia myeloid metaplasia.

Postpolycythemia myeloid metaplasia.


Cryofibrinogen in familial Mediterranean fever.


Correlation of liver and spleen size. Determinations by nuclear medicine studies and physical examination.


Mitral valve obstruction and pulmonary congestion due to malignant mesothelioma.


Removal of mercury by peritoneal dialysis.


Retropharyngeal infection in adults.

Retropharyngeal infection in adults.


The provision of ambulatory care in an urban nonuniversity setting.


Successful treatment of radiation pericarditis with corticosteroids.


The Jewish Hospital of St. Louis therapeutic grand rounds no. 6. Lactic acidosis.


Science in medicine. Some negative feedbacks.


Letter: Sickle cell disease and the kidney: a hypothesis.


Letter: Whole blood volume determinations.


Letter: Upper respiratory tract protocol.


Editorial: "Keep your cool".

Editorial: "Keep your cool".


Editorial: Types of emphysema.

Editorial: Types of emphysema.


Editorial: Tunnel tactics.

Editorial: Tunnel tactics.


Editorial: Children with jaundice.

Editorial: Children with jaundice.


Editorial: Case of acute radiation injury.


Editorial: Athletes and electrocardiograms.


Editorial: Surgery for severe obesity.

Editorial: Surgery for severe obesity.


Editorial: Conversations on the social services.


Control of tinea pedis in a swimming bath. Random samples of the weekly entry of bathers to a swimming pool were examined for tinea pedis and verruca before and at intervals after the supply of individual sachets of foot powder to all bathers.Over three and a half years the overall incidence of tinea pedis decreased from 8.5% to 2.1%, and in adult males it decreased from 21.5% to 6.9%. The incidence of infection with Trichophyton mentagrophytes var. interdigitale decreased from 5.3% to 0.5%, and the incidence of infection with T. rubrum (1.2%-1.1%) and Epidermophyton floccosum (0.9%-0.5%) did not change significantly. The incidence of verruca decreased from 4.8% to 1.2%. Issuing foot powder clearly minimizes the spread of infection and is recommended for general use.


Vertical leg drainage of odema in treatment of leg ulcers. Since oedema of adjacent tissue is a major factor in preventing healing of leg ulcers conservative treatment should aim to dry out the ulcer area before bandaging and to keep it dry afterwards. A method of postural drainage of oedema is described in which the patient lies supine with the legs raised vertically for two days. Non-stretch Viscopaste bandages are then applied and the patient allowed to move about normally, but instructed to continue vertical leg drainage for a period each day. Out of 106 cases treated by this method the leg ulcer healed within a year in 82 (77.4%). Relapses were apt to occur when the patient neglected to continue the vertical drainage regimen after the ulcer had healed. These results compare well with those reported for other methods of treatment. Vertical leg drainage treatment is inexpensive and the patient can continue at work.


Effects of posture on limb blood flow in late pregnancy. Arm and leg blood flow was measured in 40 patients in late pregnancy in the supine and left lateral positions, and the changes were contrasted with changes found in 15 patients investigated in the early puerperium. A significant reduction in leg flow occurred in the pregnant subjects when the supine position was assumed. A further 30 patients in late pregnancy had leg flow measured in the following positions: left lateral, supine, right lateral, and the two mid-positions. Leg flow significantly increased on moving from the supine to all other positions except the right intermediate position, indicating that a leftward tilt is more effective in preventing caval compression.


Degree and duration of reversal by naloxone of effects of morphine in conscious subjects. The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.


Effects of hyperthermia on bladder cancer. A study of the effect of bladder lavage with isotonic fluid at 45 degrees C on proliferative transitional cell carcinoma has shown definite cancericidal changes. These early studies suggest that further investigation of hyperthermia on a larger scale would be worth while.


Cigarette smoker's bronchitis: the effect of relighting. Male volunteers for mass radiography examination aged 40 or more were questioned about their sputum production, smoking habits, and, when applicable, their method of smoking cigarettes.Of 5,438 cigarette smokers 1,051 (19%) claimed that when smoking a cigarette they usually extinguished it at some stage and later relit it to smoke again. Anyone who admitted to producing sputum from his chest on most days of the year or on most days for a minimum of three months of the year for at least the last two years was classed, in the absence of other causative disease, as a chronic bronchitic. Such chronic bronchitics totalled 1,864 (34%).The rate of chronic bronchitis among relighters (39.7%) was higher than the rate (32.9%) among the remaining cigarette smokers. The difference was of high statistical significance (P<0.001), and the same pattern was maintained when age and consumption were standardized. After allowing for a trend towards lower social class and a preference for plain as opposed to filter cigarettes the rate of chronic bronchitis among relighters was about 15% greater than that of the remaining cigarette smokers.


Conversations on the social services. Rural views.


The aftermath of suicide.

The aftermath of suicide. Forty-four spouses of suicides followed up after five years showed no significant differences from the widowed by other causes in respect of mortality and remarriage rates. A minority were stigmatized and most found the inquest unpleasant. Outcome was evenly polarized into better off and worse off.


Medicine in China. Medicine and society.


Structure and function of a middle-sized accident department. An account of the working of a middle-sized accident department is given, based on the study of nearly 33,000 attendance records. The work load, management, and staffing as it is actually organized is briefly described. The effectiveness of the service given is bedevilled by certain features of the N.H.S.-in particular, the deplorable conditions of employment of staff in casualty departments.


Letter: Streptokinase and heparin in treatment of pulmonary embolism.


Blood and neoplastic diseases. Toxic anaemia.


Letter: Smoking in pregnancy and child development.


Letter: Smoking and leucocyte count.

Letter: Smoking and leucocyte count.


Letter: Factors affecting recognition of infant leukaemias and lymphomas.


Letter: septic abortion and the Dalkon Shield.


Letter: Can I have an ambulance, doctor?


Letter: Assessment of surgical treatment.


Letter: Renal damage caused by gentamicin.


Letter: Biochemical basis of malignant hyperpyrexia.


Letter: Jaundice after halothane.

Letter: Jaundice after halothane.


Letter: Tests for immigrant doctors.

Letter: Tests for immigrant doctors.


Drivers who refuse blood test.

Drivers who refuse blood test.


Carbon dioxide and the effect of parathyroid hormone on bone in vitro.


Phosphoenolpyruvate carboxykinase and gluconeogenesis in renal cortex of starved rats.


Effect of divalent cations on ACh contractures of depolarized denervated rat muscles.


Electrophysiological changes in the rat atrium with age.


In vivo calcium transport by rat small intestine after massive small bowel resection.


Metabolic interrelations of substrates, pH, and oxygen in perfused rabbit heart.


Localization and function of medullary sites mediating vagal bradycardia in the cat.


Vascular responses and foot temperature in pigeons.


Effects of brainstem lesions on temperature regulation in hot and cold environments.


Dynamic elasticity of cardiac muscle as measured by controlled length changes.


Glycogen repletion in different types of muscle and in liver after exhausting exercise.


A study of factors affecting renal bicarbonate reabsorption.


Renal pelvic pacemaker control of ureteral peristaltic rate.


Superoxide dismutase and pulmonary oxygen toxicity.


Enzymatic activity and divalent cation content of pancreatic juice.


Interorganal relationships of amino acid metabolism in fed rats.


Effect of gastric fundectomy on canine gastric electrical and motor activity.


Effects of anesthesia, tachycardia, and autonomic blockade on the Anrep effect in intact dogs.


Effect of confinement on ovine glucose and immunoreactive insulin circadian rhythms.


Tracheal smooth muscle and rate of oxygen uptake.


Specificity of ascorbic acid transport system of the central nervous system.


Effect of hyperosmolality on renal uridine metabolism.


Thyroid hormone control of glutathione reductase activity in rat erythrocytes and liver.


Left ventricular distensibility in newborn piglets, adult swine, young kittens, and adult cats.


Correlations between ionic contents in different regions and layers of intestinal muscles.


Renal actions of vitamin D in D-deficient rats.


Correlations between electrolyte content and spontaneous electrical activity in intestinal muscle.


A possible origin of intestinal gradients and their relation to motility.


Letter: Receptors in cerebral circulation affecting sodium excretion in the cat.


Mechanism and site of vitamin K-3 small intestinal transport.


Clinical and CSF studies in newborn infants with neurological abnormalities.


Periventricular leucomalacia in neonates. Complications and sequelae.


Brain maturation and damage in infants dying from chronic pulmonary insufficiency in the postneonatal period.


Accidental head injury in childhood.

Accidental head injury in childhood.


Cord haemoglobin in low birthweight infants.


Iron status of preterm low birthweight infants and their response to oral iron.


Familial incidence of bifid and double ureters.


Hypertrichosis with hereditary gingival hyperplasia.


Acute intermittent porphyria in childhood. A neglected diagnosis?


Effect of ascorbic acid on urinary hydroxyproline of children receiving corticosteroids.


Hydrocephalus related to pulsion diverticulum of lateral ventricle.


Thyroxine levels in normal newborn infants.


Proceedings: Plasma ethosuximide in epilepsy: clinical aid and illustration of principles.


Proceedings: Paediatric necropsy: a genetic investigation and its relation to antenatal diagnosis.


Letter: Abnormal mucosa in gastroenteritis.


The simultaneous repair of cleft lip and palate in early infancy.


An unusual foreign body in the palate.

An unusual foreign body in the palate.


Permanent records of cleft lip, nose and palate abnormalities.


The behaviour of cialit-stored and freeze-dried human fascia lata in rats.


Button compression for keloids of the lobule.


A serious complication of an operation for axillary hyperhidrosis.


Hepatitis B-specific DNA polymerase activity during post-transfusion hepatitis.


Chemical transfer of learned colour discrimination in goldfish.


Letter: McCollough colour after effect.

Letter: McCollough colour after effect.


Letter: Mouse granulocyte precursors and multiple sclerosis.


Lactate dehydrogenase in tear fluid.

Lactate dehydrogenase in tear fluid.


Topographic distribution of refractive indices in bovine lenses.


Oxygen tension distributions in the cornea: a re-examination.


An investigation of the cells incorporating (3H)GABA and (3H)glycine in the isolated retina of the rat.


Poly I:C in herpetic keratitis in rabbits.


The effect of short- and long-acting barbiturates on the oxygen uptake of the intact lens and its homogenate.


Physical and chemical changes in alpha-crystallin during maturation of lens fibers.


Collagen heterogeneity in the avian eye: lens, vitreous body, cornea and sclera.


Enzymes of energy-producing metabolism in human tear fluid.


Letter: Form of the choroidocapillaris.

Letter: Form of the choroidocapillaris.


Effect of corticosteroids on exercise-induced asthma.


Bronchial reactivities to acetylcholine and IgE levels in asthmatic subjects after long-term remissions.


The changes in the thyroid gland after irradiation with 131I or partial thyroidectomy for thyrotoxicosis.


Carcinoma of the small intestine in sheep.


A morphological study of the liver lesion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats.


Carcinosarcoma of the breast.

Carcinosarcoma of the breast.


Ultrastructural and fluorescence histochemical studies on the innervation of the tracheo bronchial muscle of normal cats and cats treated with 6-hydroxydopamine.


Experimental pigment donation in vivo.

Experimental pigment donation in vivo.


Morphological and structural investigations on Smilax aspera leaf and storage starches.


Protective sensation in the hand and its correlation to the ninhydrin sweat test following nerve laceration.


Utilization of an air splint after below-knee amputation.


Determinants of myocardial water content during cardiopulmonary bypass.


Aortic arch in the neck.

Aortic arch in the neck.


Tricuspid valve replacement. A comparative experimental study with Starr-Edwards ball valve, Beall disc valve, and Kay-Shiley disc valve with muscle guard.


The spectrum of the scimitar syndrome.

The spectrum of the scimitar syndrome.


Infection of pacemaker electrode and removal with cardiopulmonary bypass.


Tricuspid valve endocarditis. Prosthetic replacement.


Improved survival rates in dogs after extracorporeal circulation by improved control of heparin levels.


Shrinkage and degradation of the Delrin occluder in the tilting-disc valve prosthesis.


Resection of aneurysm of the transverse aortic arch. New simplified technique using permanent bypass graft and extracorporeal circulation.


Coarctation of the aorta with spontaneous quadriparesis. A case report.


Intramyocardial carbon dioxide tension. A guide to the safe period of anoxic arrest of the heart.


Cystic medial necrosis and dissecting aneurysm of the aorta in a child with congenital aortic stenosis.


Obstruction of a mitral ball-valve prosthesis by adhesions from an intact mural leaflet complex.


Absence of anatomic origin from heart of pulmonary arterial supply. Clinical application of classification.


Thrombosis of superior vena cava caused by pacemaker wire and managed with streptokinase.


Mitral stenosis in the young in developing countries.


Probable linkage of LCAT locus in man to the alpha haptoglobin locus on chromosome 16.


Relationship between tritiated poly-L-lysine binding and template activity of human chromosomes.


The role and results of surgery in the management of chronic pulmonary histoplasmosis.


Stability of the nucleoside composition of tRNA during biological ageing of mice and mosquitoes.


Hemodynamic, metabolic, and hematologic effects of pulsatile cardiopulmonary bypass.


Levamisole inactive in treatment of four animal tumours.


Periodicity in high sulphur proteins from wool.


Pattern of remyelination in the CNS.

Pattern of remyelination in the CNS.


Evidence for a gene-specific RNA determining resistance in wheat to stem rust.


Virus-like particles in Leishmania parasites.


Rats learning to work for alcohol.

Rats learning to work for alcohol.


Time as heard in speech and music.

Time as heard in speech and music.


Letter: IQ and race.

Letter: IQ and race.


Letter: Silent alleles and haploid expression in deficiency mapping.


Letter: Muscle cross-reinnervation.

Letter: Muscle cross-reinnervation.


Editorial: Fibre and moral fibre.

Editorial: Fibre and moral fibre.


Editorial: Paying for medical education.


Editorial: Choice of a mild analgesic.

Editorial: Choice of a mild analgesic.


Editorial: Mitochondrial antibodies in collagen disorders.


Sequelae of an 125I-fibrinogen detected thrombus. Forty-four patients who had a deep vein thrombosis detected with the fibrinogen uptake test were followed up three to four years later. The mild aching pains and ankle swelling that were present at the time of the thrombosis persisted or got worse in many, but there was no increase in the incidence of varicose veins. The minor self-limiting thrombosis detected with the fibrinogen uptake test should not be considered innocuous, for it can cause long-lasting symptoms.


Assessment of limulus test for detecting endotoxaemia. The occurrence of endotoxaemia in 46 surgical patients has been investigated using a sensitive preparation of limulus lysate. Altogether 23 patients with local and systemic Gram-negative infections were shown to have endotoxaemia. An overt infection is not a prerequisite for a positive limulus test result, since endotoxin can be absorbed via the peritoneal cavity in patients with "chemical" peritonitis. Over 70% of the tests performed during episodes of Gram-negative infection or peritonitis gave positive results. In 23 patients without clinical evidence of infection or peritonitis only 15% of the limulus test results were positive. The implications of these findings and the use of the test in clinical practice are discussed.


Comparison of effect of two induction doses of methohexitone on infants delivered by elective caesarean section. Observations were made on 26 infants delivered by elective caesarean section under general anaesthesia. A standard anaesthetic technique was employed using a methohexitone, relaxant, nitrous oxide-oxygen sequence with regulated ventilation and the administration of papaveretum after clamping the umbilical cord. In 12 patients the induction dose of methohexitone was 1.4mg/kg and in 14 it was reduced to 1.0 mg/kg. There were no significant differences between the two groups in the clinical status of the mothers, in operative technique and timing, or in the value of PO(2), PCO(2), and pH in the umbilical cord venous blood.The infants whose mothers received the lower dose of methohexitone were in better condition, as assessed by the number needing assisted ventilation, the time taken to establish regular respiration, the Apgar score, and the "Apgar minus colour" score.


Acute gastric dilatation in anorexia nervosa. Two patients with anorexia nervosa were treated on a general surgical unit for acute gastric dilatation. In both cases the dilatation rapidly followed an increase in the usual low dietary intake of the patients, and the ingestion of extra food may have initiated the acute episode. Conservative treatment with parenteral fluids, nasogastric intubation, and then a gradual return to a normal diet proved a satisfactory method of management. In one patient the anorexia itself was improved.


Titanium cranioplasty.

Titanium cranioplasty. The technique of repairing defects of the skull with titanium is described. The skull contour can be accurately reproduced. The technique is simpler than wiring or suturing methods. The material is inert, radiolucent, and rigid.


Hepatorenal failure with self-initiated intermittent rifampicin therapy.


Acute renal failure and rifampicin: danger of unsuspected intermittent dosage.


Clinical medicine and research in Belgium.


Six years of multidisciplinary intensive care.


Scottish automated follow-up register for thyroid disease: four years' experience in Glasgow. Four years of experience in Glasgow with an automated follow-up system for thyroid disease developed initially in a low-density population area has confirmed that the approach is a successful, practical, and exportable method of sharing long-term patient management between general practitioners and a hospital specialist clinic.


Blood and neoplastic diseases: treatment of iron deficiency and iron overload.


Letter: Hospitals and developing countries.


Letter: Deep venous thrombosis: a hypothesis.


Letter: Abdominal decompression in pregnancy.


Letter: Gonorrhoea of the pharynx.

Letter: Gonorrhoea of the pharynx.


Letter: Attitudes to abortions.

Letter: Attitudes to abortions.


Letter: Isolation system for general hospitals.


Letter: Oncology centres.

Letter: Oncology centres.


Letter: Drugs for gastric ulceration.

Letter: Drugs for gastric ulceration.


Letter: Airborne lead in Aberystwyth.

Letter: Airborne lead in Aberystwyth.


Letter: Sodium citrate and hypernatraemia in infancy.


Letter: Thromboembolism and oral contraceptives.


Letter: Musical bumps.

Letter: Musical bumps.


Letter: Amitriptyline and imipramine poisoning in children.


Letter: Was it a drug? (Optimax).

Letter: Was it a drug? (Optimax).


Letter: Adjustment of plasma calcium measurements.


Letter: Surgery in Crohn's disease.

Letter: Surgery in Crohn's disease.


Letter: Assessing the safety of comatose and postanaesthetic patients.


Letter: Diet and colonic cancer.

Letter: Diet and colonic cancer.


Letter: Nurses in administration.

Letter: Nurses in administration.


Letter: Self-administered clinical questionnaires for outpatients.


Letter: G.P.s and family planning.

Letter: G.P.s and family planning.


Letter: Private beds in N.H.S. Hospitals.


Letter: Practice expenses.

Letter: Practice expenses.


Letter: Payment for teaching.

Letter: Payment for teaching.


Letter: Nursing problems and the clinician.


Editorial: Aortic anerysms. How shall we find them?


A panel by correspondence. Fat embolism.


Cystadenoma and cystadenocarcinoma of the biliary system.


Horizons in tumor immunology. A seminar.


Autologous 125I-fibrinogen uptake test in the detection and management of venous thrombosis. A prospective study.


Total body washout and ex vivo liver perfusion in acute hepatic failure. A comparative study.


Gastric histamine metabolism after acute pyloric ligation in the Shay rat.


Cystic medial necrosis. A correctable cause of the superior vena cava syndrome.


Ovariectomy in rats with portacaval shunts. Reduction of mammary carcinoma.


Adenocarcinoma of the lacrimal gland with simultaneous pulmonary metastases.


Technique of mediastinoscopy.

Technique of mediastinoscopy.


Letter: Paper bezoar causing intestinal obstruction.


Letter: Barium studies in Meckel diverticulum.


Letter: Ambulatory surgical unit.

Letter: Ambulatory surgical unit.


Letter: Development of carcinoma in regional enteritis.


Combination chemotherapy of Hodgkin's disease.


Intrapleural nitrogen mustard for treating chylous effusion of pulmonary lymphangioleiomyomatosis.


Roentgenographic signs of tumors of the greater omentum.


The hazard of acute radiation pneumonitis in children receiving mediastinal radiation.


A comparative ultrastructural study of mesenchymal chondrosarcoma and myxoid chondrosarcoma.


Postmortem demonstration of abnormal deep pulmonary lymphatic pathways in lymphangitic carcinomatosis.


Bronchial adenoma with polymorphous features.


Hepatic pathology associated with Hodgkin's disease.


Mycosis fungoides: pathologic findings in staging laparotomies.


Hodgkin's disease of the thymus gland.

Hodgkin's disease of the thymus gland.


Mutiple carcinomas of the colon and rectum.


Familial cancer of the esophagus in Iran.


Primary carcinoma of the renal pelvis.

Primary carcinoma of the renal pelvis.


A selective patient information system.

A selective patient information system.


The use of thermovision in the detection of early breast cancer.


The screening of well women for the early detection of breast cancer using clinical examination with thermography and mammography.


Preliminary clinical observations after extended Bragg peak helium ion irradiation.


Physical characteristics of the NRL fast neutron beam for radiation therapy.


Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle.


Xeroradiography in a radiation therapy department.


The role of lymphography in patients with ovarian cancer.


Radiotherapy treatment planning using ultrasound-sonic graph pen-computer system.


Lymphography in mycosis fungoides.

Lymphography in mycosis fungoides.


A comparison of radiation control of pulmonary metastases in C3H mice by helium ions or cobalt-60 photons.


Localized Ewing's sarcoma--treatment and results.


Elective neck irradiation for TXNO squamous carcinoma of the oral tongue and floor of mouth.


Radical vulvectomy combined with elective node irradiation for TXNO squamous carcinoma of the vulva.


Prostate carcinoma: radiation treatment of the primary and regional lymphatics.


Para-aortic lymph node irradiation in carcinoma of the uterine cervix.


Para-aortic node irradiation in carcinomas.


The carcinoembryonic antigen assay in bronchogenic carcinoma.


Immunocompetence in patients with solid tumors undergoing cobalt 60 irradiation.


Protection against transplanted and spontaneous lymphoma by inoculation of heat-altered syngeneic tumor cells in splenectomized mice.


The Life Sciences Research Office.

The Life Sciences Research Office.


Letter: Some problems facing biomedical research.


Discriminable properties of drugs and state-dependent learning. Introduction.


Differentiating stimulus and storage hypotheses of state-dependent learning.


Classification of drugs according to their discriminable effects in rats.


Alcoholic blackout and state-dependent learning.


Validity of the rates of production and utilization of metabolites as determined by tracer methods in intact animals.


Tracer methodology and glucose turnover. An overview.


Glucose metabolism in ruminants: comparison of whole-body turnover with production by gut, liver, and kidneys.


Measurement and validation of nonsteady turnover rates with applications to the inulin and glucose systems.


Modeling the insulin-glucose system in man.


A two-compartment calculator for the dog glucose pool in the nonsteady state.


Intracranial hemorrhage in infants due to acquired prothrombin complex deficiency.


Ventricular perfusion in cats with kaolin-induced hydrocephalus.


Aseptic meningitis following posterior fossa surgery in children.


Fine structure of an intracerebral epithelial cyst.


Transient midbrain syndromes as a complication of vertebral angiography. Relationship to antecedent structural disease.


Traumatic vertebral-carotid-jugular arteriovenous aneurysm. Case report.


The microcirculation of peripheral nerves: techniques for perfusion and microangiographic, macrophotographic, and photomicrographic recordings in animals.


Exposure of the anterior part of the circle of Willis in the dog. Technical note.


Epidural lipoma producing spinal cord compression. Report of two cases.


Letter: Quality and quantity of neurosurgical training.


Letter: Injection of iodides into carotid artery.


Microscopic radioautography of adult rat brain cholesterol. Problem of the blood-brain barrier.


Multiple firings by cat cerebellar Purkinje cells in sleep and waking.


Transmedian innervation of canine tooth pulp in cats.


Thermal and mechanical stimulation of type II receptors and field receptors in cat.


Bursting patterns of neurons in the cat's visual cortex.


A quantitative histochemical study of early cellular events associated with destruction of myelinated axons in rat optic nerve.


Tonic and phasic effects evoked concurrently by sensory stimuli in hippocampal units.


Effects of prenatal and postnatal nutritional deficiency on brain lipid composition in rats.


A new technique for in situ hepatic isolation and perfusion in the rabbit.


Intramuscular pH needle microelectrode: a preliminary report.


What is surgical research?

What is surgical research?


The allergic patient: a force for unity.


The causes of asthma.

The causes of asthma.


The urinary metabolite of the catecholamines in asthma; its relation to the administration of corticosuprarenal hormones.


Cytotoxic testing and leukocyte increase as an index to food sensitivity.


The status of bacterial vaccines and antigens--a review of the problem.


Physicochemical correlates of olfactory quality.


Scanned ultrasonic holography for ophthalmic diagnosis.


Motor pattern production in reciprocally inhibitory neurons exhibiting postinhibitory rebound. Pairs of neurons which inhibit each other can produce regular alternating bursts of impulses if they also exhibit postinhibitory rebound (PIR). Computer studies show that stable patterns occur spontaneously in systems of pacemaker neurons with PIR, and can be triggered in systems of nonpacemakers without requiring tonic excitation. The repetition rates of these patterns are determined largely by the PIR parameters. The patterns resist perturbation by phasic synaptic inputs, but can be modulated or turned off by tonic inputs. One pair of PIR neurons can be entrained by another pair with a different repetition rate to produce more complex firing patterns.


Automatic sensitivity control in diagnostic ultrasonics.


Ondine's curse and sudden infant death syndrome: teetering on the brink.


Health care of inner-city adolescents.

Health care of inner-city adolescents.


Improving utilization of an adolescent clinic.


Pediatric and otologic aspects of clinical research in cleft palate.


The case history of an infant born to an amphetamine-addicted mother.


Cord sera antitrypsin activity and the respiratory distress syndrome.


Jaundice, hepatosplenomegaly and fever.

Jaundice, hepatosplenomegaly and fever.


Mechanisms of sensing chemical gradients by polymorphonuclear leukocytes.


Crystalline (xanthotoxin) 2-KI3.

Crystalline (xanthotoxin) 2-KI3.


Stabilisation of interferons by defensive reversible denaturation.


Hb K Woolwich the cause of a thalassaemia.


Pseudorotation mechanism of ATP hydrolysis in muscle contraction.


Capillary permeability and sympathetic activity in canine subcutaneous adipose tissue.


Intracellular electric responses to sound in a vertebrate cochlea.


In vivo enhancement of tyrosine hydroxylation in rat striatum by tetrahydrobiopterin.


Adaptation to invisible gratings and the site of binocular rivalry suppression.


Behavioural and physiological bases of drinking inhibition in water deprived rats.


Memory in enzyme membranes.

Memory in enzyme membranes.


Commercial radionuclide dispensing.

Commercial radionuclide dispensing.


Congenital rubella surveillance following epidemic rubella in a partially vaccinated community.


Hemophilia A in a female: use of factor 8 antigen levels as a diagnostic aid.


A simple protoporphyrin assay-microhematocrit procedure as a screening technique for increased lead absorption in young children.


Paroxysmal familial ventricular fibrillation.


Prevalence of coronary heart disease risk factors in boys, 8 to 12 years of age.


X-autosome translocation in normal mother and effectively 21-monosomic daughter.


Positive NBT test associated with Henoch-Schönlein purpura (HSP).


Electronically determined red cell indices in a predominantly black urban population of children 4 to 8 years of age.


Systemic infection by fusarium in a burned child. The emergence of a saprophytic strain.


A new X-linked recessive disorder with dwarfism, cerebral atrophy, and generalized keratosis follicularis.


A new syndrome resulting from partial trisomy for the distal third of the long arm of chromosome 10.


Plasma nonesterified fatty acid and blood glucose levels in healthy and hypoxemic newborn infants.


Reliability of flush blood pressure measurements in the sick newborn infant.


Amniotic fluid proteins: maternal and fetal contributions.


Continuity of pediatrician: new support for an old shibboleth.


Letter: Iatrogenic (pediatric) dental caries?


Letter: On the nomenclature of "new" syndrome.


Letter: Hyperviscosity in the neonate.

Letter: Hyperviscosity in the neonate.


Letter: Transient obstructive uropathy of megacalicosis?


Letter: Importance of dialysis in HUS.

Letter: Importance of dialysis in HUS.


Indications of direct coronary surgery and results with particular reference to endarterectomy.


Clinical experience with the dual-chambered intra-aortic balloon and System 80.


Surgical treatment of acute myocardial ischemia.


Surgical treatment for acute myocardial ischaemia.


The surgical treatment of acute myocardial infarction.


Mitral valve replacement with homograft, fascia lata and prosthetic valves: a long term assessment of valve function.


A case of intractable ventricular fibrillation successfully treated by infarctectomy at the time of operation for the valve.


Effects of methylprednisolone on pulmonary microcirculation.


Retroperitoneal migration of a pacemaker generator. An unusual complication.


A new, precise, and rapid technique of intestinal resection and anastomosis with staples.


A study of microcirculation in endotoxin shock.


The continuing problems of perforated appendicitis.


The cardiovascular subsystem in surgical patients.


Plethysmographic diagnosis of deep vein thrombosis.


Surgical hazards of co-existing anomalies in biliary atresia.


Management of cystic hygromas.

Management of cystic hygromas.


Stenosis of the renal artery and coexistent lesions.


Prognostic signs and the role of operative management in acute pancreatitis.


Editorial: Current trends in the surgical treatment of duodenal ulcer.


Fibromuscular dysplasia.

Fibromuscular dysplasia.


Cholangiography.

Cholangiography.


Increased rate of carriage of Staphylococcus aureus among narcotic addicts.


Local immunity to influenza virus in chicken tracheal organ cultures.


Follow-up of children infected in a coxsackievirus B-3 and B-4 outbreak: no evidence of diabetes mellitus.


Letter: Zoster-immune globulin for congenital varicella.


Letter: Bacteria cultured from heroin paraphernalia.


Extracellular calcium and acetylcholine-stimualted insulin secretion.


Acute metabolic effects of human growth hormone.


Studies of glucagon secretion in pancreatectomized patients.


Cerebral edema and depression of sensorium in nonketotic hyperosmolar coma.


Effects of different prostaglandins on glucose kinetics in the rat.


Insulin and glucagon degradation by the same enzyme.


Neonatal hypoglycemia: how much does it damage the brain?


Perifusion of pancreas fragments. A system for the study of dynamic aspects of insulin secretion.


Rectal absorption from aspirin suppositories in children and adults.


Leukocyte lactate dehydrogenase in bacterial meningitis.


Repeat lumbar punctures in the diagnosis of meningitis.


Congenital porencephaly.

Congenital porencephaly.


Effects of vitamin C on osteogenesis imperfecta.


Atresia of the common pulmonary vein: report of one case.


Battered child syndrome: review of 130 patients with controls.


Congenital tuberculosis: report of a case.


Hypertension, pressor agents, and cardiovascular injury: introduction.


The American Academy of Pediatrics involvement in health care financing.


Scleredema and carditis: report of a case and review of the literature.


Brain abscess in an infant with cyanotic congenital heart disease.


Letter: Enuresis treatment.

Letter: Enuresis treatment.


Letter: Mutual support groups with parents of leukemic children.


Letter: A question for Dr. Dobbing.

Letter: A question for Dr. Dobbing.


Letter: Familial congenital duodenal atresia (continued).


Letter: The effect of hexachlorophene upon intermediary metabolites, redox, and phosphorylation states in rat brain.


Letter: Comment on Russell-Silver syndrome.


Letter: Antimicrobial agents for bacterial meningitis.


Letter: Renal abnormalities in the Russell-Silver syndrome.


Editorial: Acupuncture.

Editorial: Acupuncture.


Letter: Evaluation of neck masses: the soft-tissue roentgenogram.


The anatomical localization of carcinoma of the stomach: a comparison of radiological series in Jamaican and Australian patients.


The status of immunization of children in New South Wales against diphtheria and poliomyelitis in February, 1972: a sample survey.


Diphtheria and poliomyelitis immunization in preschool children in two towns in Central New South Wales.


A study of attitudes to contraceptives in a middle-class group of women.


Psychiatry in the People's Republic of China.


Letter: Hysterotomy and termination of pregnancy.


Letter: Immunization: a survey in general practice.


Editorial: New curricula for old.

Editorial: New curricula for old.


Letter: Analgesic nephropathy.

Letter: Analgesic nephropathy.


Editorial: What is the significance of biochemical vitamin deficiency?


Editorial: Implants in surgery.

Editorial: Implants in surgery.


The foreign body in the venous system.

The foreign body in the venous system.


Outpatient termination of pregnancy.

Outpatient termination of pregnancy.


Blood vitamin levels in Aboriginal children and their mothers in Western New South Wales.


The new medical course at the University of Sydney.


The new medical course at the University of New South Wales.


New curriculum for medical course.

New curriculum for medical course.


Letter: The genesis of tumours.

Letter: The genesis of tumours.


A new synthetic agent for the induction of ovulation.


Letter: Unexpected sudden death in infancy (cot death).


Letter: Munchausen's syndrome and drug addiction.


Letter: Important planning for videotape.


Differential effect of gluten and casein diets on rat liver HMP shunt dehydrogenases.


Behavioral patterns and brain nucleic acid and pyridoxal phosphate contents of male rat progeny from vitamin B-6-repleted dams.


Effect of zine deficiency during lactation on postnatal growth and development of rats.


Vitamin E activity of gamma-tocopherol in the rat, chick and hamster.


Effect of vitamin A and methionine on growth and amino acid composition of body protein in rainbow trout fingerlings.


In vivo and in vitro utilization of labeled precursors for choline synthesis in mature Japanese quail as compared to rats.


Influence of fat and fluoride on gastric emptying of rats.


Effects of diet on amaranth (FD and C Red no. 2) toxicity in the rat.


Effect of dietary galactose on lysosomal enzymes in the chick.


Reutilization of guanido-labeled arginine in rat liver proteins and the influence of diet.


Studies on the antiscorbutic activity of ascorbate 2-sulfate in the guinea pig.


The Equal Rights Amendment.

The Equal Rights Amendment.


On the repression of rat liver HMP shunt dehydrogenases by wheat gluten.


A state health department assesses undernutrition.


Nutritional knowledge of collegiate physical education majors.


Cheese products: protein, moisture, fat, and acceptance.


Orientation program increases job satisfaction and stability.


Effect on turnover of training foodservice employees.


Problem-solving approach to nutrition education.


Hospital foodservice and central supply share distribution system.


Position Paper on nutrition education and fast foodservice.


Cyclization of the phosphate side chain of adenosine triphosphate: formation of monoadenosine 5'-trimetaphosphate. Monoadenosine 5'-trimetaphosphate has been prepared from adeno-sine 5'-triphosphate by a carbodiimide-mediated condensation. The molecule was characterized by (3l)P nuclear magnetic resonance, and its (31)P spectrum was simulated through the assumption of a three-phosphorus spin system. The molecule is highly reactive and is rapidly converted to adenosine triphosphate upon contact with water.


Assembly of chick brain tubulin onto isolated basal bodies of Chlamydomonas reinhardi. Basal bodies isolated from Chlamydomonas reinhardi will serve as initiation centers for the assembly of chick brain microtubule protein subunits (tubulin) into microtubules. The rate of microtubule assembly is tubulin-concentration dependent; this assembly occurs onto both distal and proximal ends of the basal body mnicrotubules, with distal assembly greatly favored. In vitro assembly of brain tubulin also occurs onto the mid-lateral aspects of the basal bodies, presumably onto the fiber connecting the two basal bodies.


Immediate hypersensitivity responses in flatfish. Fungal extracts that precipitate with human C-reactive protein caused immediate erythema on subdermal injection into marine flatfish. Only species with calcium-dependent serum precipitins to these fungi showed skin reactions. Immediate hypersensitivity in a nonreactive species could be induced after injection with serum from reactive species. The transferable serum factor (or factors) was heat sensitive.


Neuronal analysis of wave form in the time domain: midbrain units in electric fish during social behavior. A fish of the genus Eigenmannia responds differently to a neighboring conspecific fish with a slightly higher frequency of the electric organ discharge than its own than to one with a slightly lower such frequency than its own. When the two frequencies are beating against each other the special wave shape of the electric organ discharge leads to asymmetries of the beat pattern which are distinct for the two cases. Midbrain neurons, called "deltaF recoders," sign and magnitude of the frequency difference on the basis of these patterns. that is, in the time rather than the frequency domain.


Ocular hazard from picosecond pulses of Nd: YAG laser radiation. Seven rhesus monkeys (14 eyes) were exposed to 1064-nanometer radiation in single pulses of 25 to 35 picoseconds fromn a mode-locked Nd: YA G laser. Threshold injury resulted from single pulses with a mnean energy of 13 +/- 3 mnicrojoules. Electron microscopy of the retina revealed that damnage was highly localized in the photoreceptor and pigmented epithelial cells at the oluter retina. Membrane disruption, distorted outer segmtzents, and abnormnal melanin granules resembling fetal premelanosomnies were observed.


Hypertension--the silent hazard.

Hypertension--the silent hazard.


The foreman: at the job health and safety firing line.


Platelet and plasma fibrinogens are identical gene products. Human platelet fibrinogen has been shown to be indistinguishable from plasma fibrinogen by a variety of criteria, including subunit composition and cross-linking characteristics as judged by sodium dodecyl sulfate-gel electro phoresis, quantitative amino terminal analysis of fibrin, and the amino acid compositions of fibrinopeptides released from platelet and plasma fibrinogens is products of the same gene or genes.


Ecological genetics and natural selection in mollusks.


Sodium: stimulus for puddling behavior by tiger swallowtail butterflies, Papilio glaucus. Male Papilio glaucus butterflies are attracted to sand soaked with dillute aqueous solutions of sodium salts. A sodium ion concentration of 10(-3) molar is sufficient to stimulate puddling behavior. Acqlisition of sodiumn mnay be the main ecological function of pudding behavior.


Evolution of anuran life cycles.

Evolution of anuran life cycles.


What role does the LPN play in job health today?


Relationship of preoperative closing volume to functional residual capacity and alveolar-arterial oxygen difference during anesthesia with controlled ventilation.


Effects of methoxyflurane anesthesia on adrenal medullary catecholamine secretion: inhibition of spontaneous secretion and secretion evoked by splanchnic-nerve stimulation.


Comparative times to peak effect and durations of action of neostigmine and pyridostigmine.


Lamina-specific suppression of dorsal-horn unit activity by morphine sulfate.


Myocardial force-velocity relations during ketamine anesthesia at constant heart rate.


Comparison in vitro of isoflurane and halothane potentiation of d-tubocurarine and succinylcholine neuromuscular blockades.


Methoxyflurane metabolism and renal function after methoxyflurane analgesia during labor and delivery.


Characteristics of the American Society of Anesthesiologists' membership, 1967-1971.


Insulin and anesthesia.

Insulin and anesthesia.


Respiratory compliance in obese patients.


Hepatocellular dysfunction without jaundice after enflurane anesthesia.


Sinus bradycardia and asystole during spinal anesthesia.


Spinal hypalgesia and analgesia by low-frequency electrical stimulation in the epidural space.


The neuromuscular effects of pancuronium in infants and children.


International conference on intensive care of the newborn.


Phenacetin-induced methemoglobinemia and renal failure.


Effect of carbon dioxide elevation on renal blood flow in the fetal lamb in utero.


Coagulation studies during second-trimester abortions induced by PGF2alpha. Extensive coagulation studies have been carried out on patients undergoing second trimester abortions induced by prostaglandin F2alpha.  30 patients with intraamniotic instillation of PGF2alpha have been studied and an additional 10 patients who were aborted by the extraovular route.  Blood samples were obtained before onset of medication and at frequent intervals after beginning of drug administration as well as at the time of abortion.  Intraamniotic administration of PGF2alpha resulted in increased levels of fibrinogen, platelets, factors 8 and 5, profibrinolysin, and fibrinolytic inhibitors during the 24 hour period after beginning of medication.  The rise in the coagulation factors is suggestive of mild inflammatory process not associated with infection.  Most of the indices have returned to normal levels shortly after expulsion of the fetus and placenta.  Only 1 patient receiving PGF2alpha showed evidence of fibrin monomer formation as determined by protamine sulfate precipitation.  Extraovular results were similar.  The results have been compared to those obtained in this laboratory following hypertonic saline.  With saline the results show a decrease in many factors, indicating disseminated intravascular coagulation.  PGF2alpha may provide a safer method of second trimester abortion as far as the coagulation mechanism is concerned than does hypertonic saline.


Apparent pseudopuberty in a phenotypic female with a gonadal tumor and an autosome-Y chromosome translocation.


Consumer control of carcinoma of the cervix.


Use of the Gravlee Jet Washer in routine screening of asymptomatic postmenopausal women.


Squamous metaplasia of the endometrium in women with an intrauterine contraceptive device: Follow-up study.


The effects of hormones and chemotherapeutic agents on rat uterine adenocarcinoma cells in tissue culture.


Histopathologic analysis of preoperative radiation therapy in endometrial carcinoma.


The pregnant patient in conflict about abortion: a challenge for the obstetrician.


Molecular weight and subunit structure of delta-crystallin from embryonic chick lens fibers.


Aging effects on the bovine lens gamma-crystallins.


The subunit structure of chick beta-crystallins.


The antigenic structure of chick beta-crystallin subunits.


Letter: The potential difference of the rabbit lens.


Editorial: Bladder carcinogenesis in rats and mice: possibility of artifacts.


Synthesis of human placental alkaline phosphatase in vitro by the ChaGo cell line.


Epizootic neoplasms in the clam Macoma balthica (L.) from Chesapeake Bay.


Cancer morbidity among two male cohorts with increased alcohol consumption in Finland.


Comparative rates of dead tumor cell removal from brain, muscle, subcutaneous tissue, and peritoneal cavity.


Comparative frequency of dominant and recessive markers for drug resistance in Chinese hamster cells.


Cytogenetic studies on the mechanism of formation of isoantigenic variants in somatic cell hybrids. I. Banding analyses of isoantigenic variant sublines derived from the fusion of TA3Ha carcinoma with MSWBS sarcoma cells.


Histogenesis and fine structure of peritoneal tumors produced in animals by injections of asbestos.


Breakdown of Gross virus-induced tolerance in rats by inoculation of lymphoid cells.


Hormone-dependent mammary tumors in strain GR-A mice. I. Alternation between ductal and tumorous phases of growth during serial transplantation.


Effect of beta-oxidized nitrosamines on Syrian golden hamsters. II. 2-Oxopropyl-n-propylnitrosamine.


Influence of nonsteroid anti-inflammatory agents on protein synthesis and hyperplasia caused by a tumor promoter.


Protection by corynebacterium granulosum against radiation-induced enhancement of artificial pulmonary metastases of a murine fibrosarcoma.


Immediate and delayed effects of nitrogen mustard on cell replication in an autogenous rat sarcoma.


In vitro evidence of specific BCG-induced immunity to malignant melanoma in BALB-c mice.


Neuraminidase-induced enhancement of tumor growth in mice.


In vitro activation of armed macrophages and the therapeutic application in mice.


Induction of macrophage-mediated tumor-cell cytotoxicity by pyran copolymer.


Immunization of lymphocytes from cancer patients.


Small, virus-like particles detected in bovine sera by electron microscopy.


Editorial: Experiments on children.

Editorial: Experiments on children.


Letter: Transportation of sick neonates.


Letter: Ureteral ectopia.

Letter: Ureteral ectopia.


Letter: Positioning in respiratory distress.


Letter: Psychotic symptoms due to meperidine intoxication.


Letter: Reaction to acetaminophen.

Letter: Reaction to acetaminophen.


Editorial: Porn.

Editorial: Porn.


PMA deaths in Ontario.

PMA deaths in Ontario. A new street-drug, para-methoxyamphetamine (PMA), recently made its appearance in Ontario. Between March and August 1973 there were nine deaths of young people in this province that were attributed to the drug. PMA appears to have a powerful hallucinogenic effect as well as a marked toxicity to the central nervous system. The clinical picture resembles that observed in cases of acute poisoning by amphetamine and methylenedioxyamphetamine (MDA).


A comparison of hexachlorophene and lactacyd on growth of skin flora in healthy term newborn infants. Reports of toxicity from the routine bathing of newborn infants with hexachlorophene resulted in discontinuing its use in the newborn nurseries of the Ottawa Civic Hospital, only to be followed by an outbreak of skin infections. As a result, a controlled trial of bathing newborn babies with either Lactacyd or pHisoHex was begun. The efficacy of the soaps was evaluated by comparing the colonization of the nose and umbilical cords of 158 pHisoHex-washed babies and 156 Lactacyd-washed babies on the day of discharge from hospital. The gram-negative and gram-positive bacterial flora of nose and cord of infants washed with pHisoHex and Lactacyd were identical in frequency and distribution.


Editorial: Participation: a useful practice.


Halofenate versus clofibrate in the management of true diabetes insipidus. The antidiuretic effect of two chemically related drugs, clofibrate and halofenate, was tested in a patient with pitressin-sensitive diabetes insipidus. The conventional daily dosage of 2 g clofibrate failed to control the symptoms of this patient; in order to obtain an adequate response the dosage had to be increased to 4 g daily.Halofenate at a dosage of 2 g daily, an amount equivalent in hypolipidemic activity to 4 g per day of clofibrate, significantly reduced water intake and output, while urinary osmolarity was markedly increased.It is concluded that (1) the antidiuretic effect of clofibrate may be dose-related, and that (2) halofenate also possesses some antidiuretic activity.


Ontario task force stresses primary care, team approach for health care system.


Altruistic self-interest and rigorous confusion: a study of a polemic.


'Abortion act gains outweigh drawbacks'--British inquiry.


Survey shows 75 per cent of Canadian women give fear as reason for delay in seeking medical aid.


Reversal by progesterone of barbiturate blockade of ovulation: effect on concentration of serum LH.


125I versus 75se labeling of fibrinogen for measuring turnover of canine fibrinogen.


Pulmonary effects of prolonged sympathetic stimulation.


Progesterone concentration in milk and blood during pregnancy in cows.


N-acetylprocainamide: an active metabolite of procainamide.


Inhibition of oxytocic responses to oxytocin in pregnant rats by (1-L-penicillamine)oxytocin and (1-beta-mercapto-beta, beta-diethylpropionic acid)oxytocin.


Erythrocyte membrane proteins in sickle cell anemia.


Clearance of human interferon in rabbits induced to make rabbit interferon.


The influence of progesterone on adrenocortical function in the rat.


DNA repair inhibition: a new mechanism of action of steroids with possible implications for tumor therapy.


Effect of acute ethanol administration on duodenal calcium transport.


Renal tubular secretion of pralidoxime in man.


Effects of quinidine on venous responses to adrenergic and nonadrenergic constrictor stimuli: indirect evidence of two sites of action in vascular smooth muscle.


In vitro observations on the binding of vitamin B12 by serum proteins and the effect of cells on the process.


Human testicular cultures: I. Chromosome analyses.


Contraction and volume changes of glycerol treated rabbit polymorphonuclear leukocytes induced by ATP and Ca 2 ion.


Induction of interferon in hereditarily asplenic mice with and without a neonatal spleen cell transplant.


Effect of intraluminal amiloride on Na transport in the rat proximal tubule.


Incorporation of 32Pi and other radioactive precursors into lecithin of brain slices of triton WR-1339 injected rats.


Effects of dietary vitamin D levels on the in vitro mineralization of chick metaphyses.


Concentration of immature and mature granulocytes from normal human bone marrow.


Suppression of plasma renin activity by propranolol: correlation with plasma propranolol levels.


Effect of intermittent electric shock on plasma renin activity in rats.


Radioimmunoassay determinations of gonadotropic hormone content in different regions of male and female rat adenohypophyses.


Unerupted dentition secondary to congenital osteopetrosis in the Osborne-Mendel rat.


Depth of immersion as a determinant of the natriuresis of water immersion.


Aryl hydrocarbon hydroxylase induction in mouse peritoneal macrophages and blood-derived human macrophages.


Aldolase in cultivated human fibroblasts.


Effects of vitamin E-deficiency on guinea pig lysosomes.


RNA biosynthesis during development of chick embryo.


Physicochemical properties of RNA of salmonid hematopoietic necrosis virus (Oregon strain).


Changes in response to calcitonin following prolonged administration to intact rats.


Ninety day subchronic toxicity of N-2-fluorenylacetamide (2-FAA) in C57BL-6j and BALB-cStCr1BR mice.


Pulmonary artery catheterization and wedge pressure measurement in the general intensive therapy unit.


Sciatic nerve block by the anterior approach for operations on the lower extremity.


Ventilatory effects of isoflurane (Forane) or halothane when combined with morphine, nitrous oxide and surgery.


Bronchoscopic removal of inhaled foreign bodies in children.


A comparison of the pulmonary response to the endotracheal instillation of 0.1 N hydrochloric acid and Hartmann's solution in the rabbit.


A new soluble acetylsalicylic acid derivative in the treatment of postoperative pain.


Letter: A technique of orotracheal intubation.


Changes in urine osmolality and urine fluoride concentrations following methoxyflurane anaesthesia.


Continuous lumbar epidural block in labour in the presence of a Meureig Williams plate from L1-L4.


Letter: Concentrations of diazepam in adipose tissue of children.


Inferior vena caval occlusion in the left lateral position. A case report.


Detection and sizing of acute myocardial infarcts with 99mTc (Sn) tetracycline.


Activated prothrombin concentrate for patients with factor VIII inhibitors.


Blood ammonia levels in advanced cirrhosis during therapeutic elevation of the insulin:glucagon ratio.


Medicine, socialism, and totalitarianism: lessons from Chile.


Inadequacy of papanicolaou smears in the detection of endometrial cancer.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-1974.


Editorial: Radioisotopic assessment of myocardial infarction.


Editorial: Factor VIII inhibitors.

Editorial: Factor VIII inhibitors.


Alternative proposals for future organization and financing of personal health services.


Letter: Determinants of serum ribonuclease levels.


Letter: Hodgkin's disease in schoolteachers.


Letter: Granulocyte collection by leukapheresis.


Letter: Effectiveness of coronary-care units.


Letter: Procaine for malignant hyperthermia.


Letter: Multiple sclerosis and brain consumption.


Letter: Stability of aspirin in propoxyphene compound dosage forms.


Letter: Cyclophosphamide activation and corticosteroids.


Letter: Toxicity of sodium cyanate.

Letter: Toxicity of sodium cyanate.


Letter: Standardized reporting of laboratory data.


Letter: Hepatic bridging--a semantic collapse.


Medicine and public affairs. Research leaders seek White House role.


Experimental staphylococcal mastitis in the mouse: effects of extracellular products and whole bacterial cells from a high-virulence and a low-virulence strain of Staphylococcus aureus.


The effect of methicillin on skin lesions in guinea-pigs caused by "methicillin-sensitive" and "methicillin-resistant" Staphylococcus aureus.


Resistotyping of Staphylococcus aureus.

Resistotyping of Staphylococcus aureus.


Pulmonary function in alcoholics.

Pulmonary function in alcoholics.


Staging laparotomy in Hodgkin's disease. Further evidence in support of its clinical utility.


Chronic inorganic mercury poisoning due to laxative abuse. A clinical and ultrastructural study.


Clinicopathologic conference: Infiltrative gastrointestinal disease.


"Malignant" hypertension resulting from atheromatous embolization predominantly of one kidney.


Analysis of interacting cell populations in cultures of marrow from patients with neutropenia.


Ethylene glycol poisoning.

Ethylene glycol poisoning.


Serum colony-stimulating activity of dogs with cyclic neutropenia.


An animal model of chronic aplastic marrow failure. I. Late marrow failure after busulfan.


In vitro production of erythropoietin by kidneys perfused with a serum-free solution.


Cycling characteristics of human lymphocytes in vitro.


Acetylation and methylation of histones in pernicious anemia.


Letter: Acquired aphasia.

Letter: Acquired aphasia.


Letter: Perinatal intensive care.

Letter: Perinatal intensive care.


Letter: Trimethoprim-sulfamethoxazole: in vitro sensitivity of 1000 clinical isolates.


Letter: Friends of Hippocrates.

Letter: Friends of Hippocrates.


Chromoconfusion: a new type of pill-pill "interaction" in cardiology.