Bone disease in hemodialysis patients with particular reference to the effect of fluoride. Forty-one patients on our chronic hemodialysis program were assessed for the degree of progression of bone disease over an average period of 46 months. Seven patients were using a fluoridated dialysate. Four of these seven patients developed a marked increase in osteoid as judged by bone biopsy, while in the nonfluoridated group the amount of osteoid remained within normal limits.In the absence of fluoride, although osteitis fibrosa occurred, it was reversible in 10 out of 12 cases by dihydrotachysterol treatment, and overall there was no evidence of progression of bone disease at the end of the study period.


Experience with the cumulative integral method for measurement of glomerular filtration rate. The glomerular filtration rate (GFR) was estimated using (125)I-iothalamate by the cumulative integral method in 95 subjects - 16 normal subjects and 79 patients with suspected or proved renal disease. This method is accurate, simple to perform and theoretically sound. It minimizes errors due to transit time and bladder storage. The normal range of GFR was determined to be 71 +/- 10 (two standard deviations) ml/min/m(2). In 66 patients serum creatinine levels were compared with the GFR value expressed per square metre. For any given serum creatinine level there is a wide range of GFR values. A serum creatinine value in the normal range, i.e. between 0.7 and 1.3 mg/dl, cannot be used to predict the patient's GFR. The micro blood sampling technique makes this method particularly useful in infants.


Paracervical block with bupivicaine.

Paracervical block with bupivicaine. Ninety-five cases in which paracervical block was administered in labour are reported. These permitted comparison of the duration of analgesia provided by 1% lidocaine and 0.25% bupivicaine, with and without adrenalin.The dangers of paracervical block are reviewed and its role in modern obstetrics is discussed.


Medical research policy for Canada. I. The evolution and convolution of policy, politics and dollars.


Emphysematous pyelonephritis.

Emphysematous pyelonephritis. A case of emphysematous pyelonephritis with perirenal gas is presented. This patient underwent vigorous medical treatment followed by nephrectomy and survived. This condition has a high mortality and should be distinguished from less severe infections where gas is confined to the collecting system. This case and others previously reported suggest that treatment should initially be medical, followed by early surgical intervention consisting of either drainage or nephrectomy depending upon the degree of renal involvement.


A first for Canada: Peterborough clinic undergoes accreditation survey.


Quebec Professional Corporation of Physicians certifies specialists; can inspect and discipline.


Seat belts: is freedom of choice worth 800 deaths a year?


Whatever happened to that advisory service provided by yesterday's community sage?


A clinicopathologic study of vertical eye movements.


Optic neuritis in systemic lupus erythematosus.


Transient benign unilateral pupillary dilation in young adults.


Hereditary hypertrophic neuropathy with facial and trigeminal involvement. Report of a case and comments on its possible identity with Hellsing syndrome.


Reversible forms of motor neuron disease. Lead "neuritis".


Idiopathic giant cell polymyositis. Report of a case and review of the syndrome.


The photoconvulsive response. Modification by monocular occlusion in man.


Recurrent hemichorea following striatal lesions.


Diphenylhydantoin concentrations in saliva.


Quadriceps myopathy--entity or syndrome?


Hemifacial spasm in childhood treated with carbamazepine.


Familial Q-T prolongation syndrome. Convulsive seizures and paroxysmal ventricular fibrillation.


Hyperlipidemic dementia.

Hyperlipidemic dementia.


Letter: Batten disease.

Letter: Batten disease.


The control of bile acid pool size: effect of jejunal resection and phenobarbitone on bile acid metabolism in the rat. In patients with cholesterol gallstones, there is a diminished bile acid pool and the bile becomes supersaturated with cholesterol. Medical treatment has been aimed at re-expanding the pool to improve cholesterol solubility in bile but as yet the factors controlling the size of the bile acid pool' are unknown. Therefore the role of the liver and intestine in controlling bile acid pool size in the rat was studied and the effect of experimental expansion of the pool on bile acid metabolism and bile lipid composition examined. Bile acid absorption was increased from ileum made hyperplastic by previous jejunectomy and hepatic bile acid synthesis was increased by phenobarbitone treatment. Both jejunal resection and phenobarbitone significantly increased the size of the bile acid pool from 32.2 +/- SEM 0.94 mumoles/100 g body weight to 42.2 +/- 1.71 and 44.4 +/- 2.03 respectively. However, the effects of these experimental manipulations on bile acid secretion rate, enterohepatic cycling frequency, and synthesis rates were quite different. Jejunectomy caused a 56% increase in bile acid secretion and more rapid cycling of the bile acid pool but the enhanced absorption did not depress bile acid synthesis. In contrast, phenobarbitone markedly increased synthesis from 14.5 +/- 1.42 mumoles.100 g BW(-1). 24 hr(-1) to 25.9 +/- 3.19 but there was no significant change in bile acid secretion and the choleresis seen after phenobarbitone was mainly due to an increase in the bile acid-independent fraction of bile flow. In these experimental studies in the rat, expansion of the bile acid pool did not significantly change bile lipid composition or cholesterol solubility in bile.


Bile salt metabolism in tropical sprue.

Bile salt metabolism in tropical sprue. Mean and peak jejunal bile salt concentrations during digestion of a standard fat meal were found to be significantly lower in six Puerto Rican patients with untreated tropical sprue, all of whom had steatorrhoea, than in six asymptomatic subjects who had normal fat absorption. Bile salt pool size and turnover time did not differ significantly in the two groups.It is suggested that bile salt concentrations may be reduced in the proximal small intestine of patients with tropical sprue as a result of excessive dilution by intestinal fluid. The finding of low bile salt concentrations in two asymptomatic subjects indicates that bile salt lack alone may not be sufficient to produce steatorrhoea.


Simplified cholangiography using ioglycamide. Intravenous cholangiograms were performed on 100 unselected nonicteric patients using methylglucamine ioglycamide (Biligram). Fifty patients received 10.5 g of contrast medium and 50 received 5.25 g of medium. The contrast medium was injected evenly over five minutes. Side effects were recorded in only 13% of patients and all were mild. Radiographs were taken 10, 30, 60, 90, and 120 minutes after injection and were assessed without the authors being aware of the dose of contrast medium injected.Better statistically significant results were obtained using the higher dose.In patients in whom the gallbladder is present, films taken at 60 minutes and 90 minutes after injection give the maximum available information in 97% of cases. If the gallbladder has not become opacified by 60 minutes, cystic duct obstruction is indicated. In postcholecystectomy patients, films at 30 minutes and 60 minutes after injection give the maximum available information in 95% of cases.


Secretion of water and electrolytes into the duodenum in normal subjects and in patients with cirrhosis: the response to secretin and pancreozymin. The increased volume of duodenal juice secreted by cirrhotic subjects in response to secretin was confirmed in 10 patients when their response was compared with that in eight normal subjects. This volume increase was associated with an increased sodium and chloride output while bicarbonate output was normal. The increment in volume of juice secreted by the cirrhotic patients was thus made up of an isotonic sodium chloride solution. The differences in anion concentrations and outputs are similar to reported changes produced in normal subjects given increasing doses of secretin. On the basis of these observations it is suggested that the increased output of duodenal juice in cirrhotic patients may be due to the infused secretin exerting a greater effect than in normals, possibly consequent upon an impaired secretin removal rate in the abnormal liver.


Cellular infiltrate of jejunal biopsies in adult coeliac disease in relation to gluten withdrawal. A comparison has been made of inflammatory cell counts in the lamina propria and epithelium of jejunal biopsies in 11 patients with adult coeliac disease with those found in 12 control subjects. In the coeliac patients, there were significant increases in the numbers of total cells, plasma cells, and intraepithelial lymphocytes, but a significant reduction in lamina propria lymphocytes. Following clinical improvement on a strict gluten-free diet, significant changes in cell counts occurred, but with the exception of lymphocytes in the lamina propria, the counts were still abnormal. Analysis of five patients in whom the biopsy improved to near normal morphology and of six in whom there was no such improvement showed that significant falls in plasma cells and rises in lymphocytes in the lamina propria could occur without improvement in other morphological appearances. These results seem relevant to the problem of diagnosing coeliac disease in patients who, on gluten withdrawal, show an unequivocal clinical response, but no gross morphological improvement in the jejunal biopsy. On the basis of the observed changes in cell counts, there seems little justification in questioning the diagnosis of coeliac disease in such patients.


Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's disease. Sera from 92 patients with adult coeliac disease, 20 patients with Crohn's disease, and 89 control patients were tested for the presence and immunoglobulin class of anticonnective tissue antibodies. In adult coeliac disease patients taking a normal diet there was a high frequency of sera positive for connective tissue antibodies and the majority were IgA in class. Following gluten withdrawal, IgA class connective tissue antibody activity was strikingly reduced. No such antibody activity was detected in concentrated jejunal fluid collected from 15 patients with adult coeliac disease, seven of whose sera were positive for connective tissue antibody. Connective tissue antibody activity was not absorbed by fractions of gluten. Similarly, preparations of human reticulin and glomerular basement membrane together with elastin and collagen failed to absorb connective tissue antibody.


The dynamic structure of a flat small intestinal mucosa studied on the explanted rat jejunum. Small pieces of jejunum with an intact blood supply were explanted to the anterior abdominal wall in rats. Six weeks after explantation the mucosa appeared totally flat in many areas, both histologically and under the dissecting microscope. The structure of the flattened mucosa was shown to be identical to that in coeliac disease with hypertrophied intervillous ridges. A dynamic study with tritium-labelled thymidine demonstrated a considerably increased turnover in the flat mucosa with some disorganization of cell production and migration.


A study of peripheral leucocyte migration in agarose medium in inflammatory bowel disease. THE MIGRATION OF PERIPHERAL LEUCOCYTES FROM PATIENTS WITH INFLAMMATORY BOWEL DISEASE WAS INVESTIGATED USING AN AGAROSE PLATE TECHNIQUE AND THREE ANTIGENIC MATERIALS: (1) the enterobacterial common antigen of Kunin; (2) extract from germ-free rat faeces; and (3) Kveim suspension from a sarcoid spleen K19. Inhibition of migration was obtained only with Kunin antigen. It was present in 11 out of 20 patients with ulcerative colitis and in four out of 20 patients with Crohn's disease but in only one out of 33 control subjects. These findings suggest the possibility that a state of cellular immunity to enterobacterial common antigen may exist in inflammatory bowel disease. Lack of cellular reactivity to extract from germ-free faeces and Kveim suspension is in contrast with the results obtained by others by means of the capillary tube method and requires further investigation.


Rectal biopsy and precancer in ulcerative colitis. Forty-seven patients with ulcerative colitis subjected to elective proctocolectomy were investigated with regard to the occurrence of precancerous changes in the rectal biopsy and the operation specimen. In the rectal biopsy from seven patients precancerous lesions were found and in the operation specimens from these patients precancer was also found in other parts of the colon. In five of these patients the precancer was associated with carcinoma and in four of the patients the tumour had not been detected before operation. It is concluded that rectal biopsy is of great value in patients with ulcerative colitis for detection of early cancer and patients at risk of developing a colitis carcinoma.


Proceedings: Death after partial gastrectomy for peptic ulcer--a long-term study.


The collection of pancreatic fluid for cytodiagnosis using a duodenoscope.


Proceedings: The pH-dependent effect of sodium taurocholate on increasing gastric mucosal permeability.


Proceedings: The effects of aspirin, carbenoxolone, and gefarnate on the gastric mucosal potential difference in man.


Proceedings: Postoperative duodenogastric reflux: a cause of gastritis and symptoms.


Proceedings: Gastric epithelial cell turnover after acute and chronic alcohol ingestion.


Proceedings: Secretin release in man after intra-duodenal acid.


Proceedings: Abnormalities of cholecystokinin secretion and gallbladder emptying in coeliac disease.


Proceedings: Collagenous basement membrane thickening in jejunal biopsies from patients with adult coeliac disease.


The cellular infiltrate of the jejunum in coeliac patients with complicating lymphoma.


Proceedings: A study of the electrical potential difference (PD) across human ileostomy mucosa.


Proceedings: Functional differentiation of the human jejunum and ileum.


Proceedings: The effects of different doses of chenodeoxycholic acid and of withdrawing treatment on bile lipid composition and liver function in patients with gallstones.


Proceedings: A malabsorption syndrome in overland travellers to India: mucosal colonization by bacteria.


Proceedings: A prospective survey of the treatment of acute pancreatitis.


Proceedings: Studies on carriers of Australia antibody.


Proceedings: Liver disease in healthy blood donors associated with presence of hepatitis B antibody.


Proceedings: Cell-mediated immunity to hepatitis B antigen in antigen-negative active chronic hepatitis.


Proceedings: The progress of children with intrahepatic cholestasis.


Proceedings: Liver damage in patients taking methyldopa.


Proceedings: Renal failure and site of abnormal renal retention of sodium in fulminant hepatic failure.


Proceedings: Biocompatibility in a system of artificial liver support for fulminant hepatic failure.


Proceedings: Serum ferritin in patients with iron overload and with acute and chronic liver disease.


Proceedings: Experimental production of lipoprotein X (LPX) in the absence of obstructive jaundice.


Proceedings: A prospective follow up of outpatients with 'total colitis'.


Proceedings: Mucin changes in colonic mucosa in colorectal carcinoma.


Proceedings: Heredity and bowel cancer.

Proceedings: Heredity and bowel cancer.


Proceedings: An experimental animal model of Crohn's disease.


Proceedings: Antibody production to the bacteriophage phi chi 174 in patients with Crohn's disease.


Proceedings: The incidence and prevalence of Crohn's disease in the Nottingham area.


Proceedings: Oral lesions in patients with Crohn's disease.


Proceedings: The results of outpatient treatment of haemorrhoids by rubber band ligation.


Proceedings: The diagnosis of pseudomembranous colitis by rectal biopsy.


Proceedings: Osmotic, electrolyte, and pH changes in the human jejunum after truncal vagotomy and drainage.


Proceedings: The predictive accuracy of the insulin test after vagotomy: a new interpretation.


Proceedings: Characterization of glucagon responses to different meals in the dumping syndrome.


Proceedings: Effects of varying degrees of vagotomy on the gastroduodenal response to food.


Proceedings: The influence of the innervated gastric antrum on gastrin and acid responses to insulin hypoglycaemia in man.


Control of ocular movement.

Control of ocular movement.


Epidemiology of strabismus.

Epidemiology of strabismus.


Relevance of the AC-A ratio.

Relevance of the AC-A ratio.


Management of acquired esotropia.

Management of acquired esotropia.


Management of paralytic strabismus.

Management of paralytic strabismus.


Defects of ocular movement and fusion after head injury.


Management of microtropia.

Management of microtropia.


Electrophysiology of the retraction syndromes.


Surgical management of Duane's syndrome.


Surgery of muscle adhesions and effects of multiple operations.


Sensory anomalies in strabismus.

Sensory anomalies in strabismus.


Strabismus. Summing up.

Strabismus. Summing up.


Letter: Anaesthesia for laryngoscopy and microsurgery of the larynx.


Communication between paranasal sinuses and meninges after trauma. A radiological exercise using spiral tomography.


Importance of pharmacokinetics and dosage in digoxin maintenance therapy. A retrospective analysis of serum digoxin levels.


Radiology of acute toxic megacolon.

Radiology of acute toxic megacolon.


Ruptured splenic artery aneurysm.

Ruptured splenic artery aneurysm.


The Brachmann-De Lange syndrome. Report of two cases.


Psychiatric services in Matabeleland. A comparison with services existing in developed countries.


Editorial: Isoniazid and the liver.

Editorial: Isoniazid and the liver.


Effect of hypocapnia on pulmonary mechanics in normal subjects and in patients with chronic obstructive lung disease.


Pharmacokinetic studies with an isoniazid slow-releasing matrix preparation.


The effect of lateral positions on gas exchange in pulmonary disease. A prospective evaluation.


Anaerobic infections of the lung and pleural space.


Multiple myeloma with pleural involvement.


Maximal extent of visualization of bronchial tree by flexible fiberoptic bronchoscopy.


High dose ethambutol; an oral alternate for intermittent chemotherapy.


Review articles.

Review articles.


Letter: Rifampin in initial treatment of pulmonary tuberculosis: a U.S. Public Health Service tuberculosis therapy trial.


Letter: Drug combinations in the treatment of hypertension.


Transkei foot.

Transkei foot.


The prevalence of hepatitis B (Australia) antigen in Southern Africa.


Local experience in the treatment of acute non-lymphoblastic leukaemia.


Social aspects of epilepsy.

Social aspects of epilepsy.


Trends in the education of children with epilepsy.


Further studies on carbon dioxide fixation in Chlorobium.


Gamete activity in mating strains of Chlamydomonas eugametos.


Changes in the free nucleotide pattern of spores from Phycomyces in relation to heat-induced germination.


Physical and chemical properties of the nitrogenase proteins form Azotobacter vinelandii.


Malpractice-settle or defend?

Malpractice-settle or defend?


Influence of breed somatotypes on prevalence of hip dysplasia in the dog.


Canine skeletal chondrosarcoma: a clinicopathologic study of 35 cases.


Triceps tenotomy approach for distal fractures of the canine humerus.


Prosthetic radial carpal bone in a mare.


Cortex screws for repair of long spiral humeral fractures in dogs and cats.


Experimental study on the male pattern alopecia. I. Differences between the testosterone transport protein in bald and hairy areas.


On the nature of the forces involved in the sex-directed flocculation of a fission yeast.


Sulfate uptake as a measure of planktonic microbial production in freshwater ecosystems.


Multiple components of beta-N-acetylhexosaminidase from equine kidney. Their action on glycolipids and allied oligosaccharides.


Viscometric demonstration of tubulin polymerization.


The broad aglycon specificity of alpha-l-fucosidase from marine gastropods.


Purification and kinetic studies of wheat bran beta-amylase. Evaluation of subsite affinities.


Studies on luciferase form Photobacterium phosphoreum. V. An enzyme-FMN intermediate complex in the bioluminescent reaction.


Characteristics of the inhibition of ornithine-delta-aminotransferase by branched-chain amino acids.


Studies on acyl donors for plasma cholesterol esterification. Triglyceride fatty acids in rats in vivo.


Studies on violet-colored acid phosphatase of sweet potato. I. Purification and some physical properties.


N-acyl specificity of Taka-N-acetyl-beta-D-glucosaminidase studied with synthetic substrate analogs. 3. Effects of alpha-hydroxyl and alpha-methoxyl substituents of the substrate-2-acetamide group on enzymatic hydrolysis.


Studies on violet-colored acid phosphatase of sweet potato. II. Enzymatic properties and amino acid composition.


Isolation of an inhibitor of beta-glucuronidase from human saliva.


Antigenicity of monocomponent porcine insulin in rabbits.


Influence of altered states of calcium homeostasis on insulin secretion in rats and rabbits.


Lack of post prandial exercise-induced growth hormone secretion in normoglycemic insulin-treated diabetic men.


Effects of some psychoactive agents on prolactin secretion in rats of different endocrine states.


In vivo incorporation of labelled amino acid into different protein fractions of the rat thyroid gland.


Computer analysis of early thyroxine distribution in thyrotoxicosis and hypothyroidism.


Possible age-dependent influence of estrogens on the binding of testosterone in plasma of adult men.


Effect of adrenaline on plasma vitamin C levels in normal subjects.


Free triiodothyronine (t3)- and thyroxine (t4) serum levels in old age.


Effect of 11-deoxycorticosterone on cholesterol sidechain cleavage by adrenal cortex mitochondria.


Ethanol effect on glucagon secretion in the pig.


Sodium ion transport in isolated intestinal epithelial cells. The effect of actively transported sugars on sodium ion efflux.


Calcium requirement for assemby of the lipid-containing bacteriophage PM2.


Calcium binding to placental plasma membranes as measured by rate of diffusion in a flow dialysis system.


Correlation between calcium ion binding to chloroplast membranes and divalent cation-induced structural changes and changes in chlorophyll a fluorescence.


Acetylcholine esterase as a probe for erythrocyte-membrane intactness.


Interaction of vasopressin with phosphatidylserine bilayers.


Temperature dependence of the action potential in Nitella flexilis.


The efficiency of energetic couping between Na+ flow and amino acid transport in Ehrlich cells-a revised assessment.


A new haemoglobin J-Habana-alpha71(E20) alanine leads to glutamic acid.


The influence of pH, Ca2+ and protein on the thermotropic behaviour of the negatively charged phospholipid, phosphatidylglycerol.


A fluorescence study of the interactions between kappa-and alphaS1-casein and between lysozyme and ovalbumin.


Biosynthesis of edeine. Fractionation and characterization of enzymes responsible for biosynthesis of edeine A and B.


N-terminal amino acid sequence of trypsinogen from the elephant seal Mirounga leonina L. (Carnivora).


Circular dichroism of squid retinochrome.


Increased conversion of a phenylalanine load to tyrosine in tetraiodoglucagon-treated rats.


Interaction of cytosol DNA-binding proteins with adenine-rich polynucleotides.


Snake venom toxins. The complete amino acid sequence of cytotoxin VII4 from the venom of Naja mossambica mossambica.


Nanosecond fluorescence decay study of mitochondria and mitochondrial membranes.


Effects of superoxide radicals on myoblast growth and differentiation.


An analysis of the degree of homology between 28S rRNA from Xenopus laevis and Xenopus mulleri.


Terminal deoxynucleotidyl transferase and DNA polymerase in classes of cells from rat thymus.


Bilirubin binding to myelin basic protein, histones and its inhibition in vitro of cerebellar protein synthesis.


The lizard ear: Gekkonidae.

The lizard ear: Gekkonidae.


Myelin movements in mature mammalian peripheral nerve fibers.


The spermatozoon of arthropoda. XXIV. Sperm metamorphosis in the diplopod Polyxenus.


The clinical use of operant learning approaches: some complex issues.


Influence of neuroleptics and benzodiazepines on metabolism of tricyclic antidepressants in man.


Medical, nonmedical, or antimedical models for mental health centers?


Child abuse: pathological syndrome of family interaction.


Attention in young children of psychotic mothers.


Editorial: Work.

Editorial: Work.


Computer EEG and auditory evoked potential investigations in children at high risk for schizophrenia.


Life events, subjective stress, and traffic accidents.


The three sisters: transexual male siblings.


Tardive and withdrawal dyskinesia associated with haloperidol.


Bromide abuse: a continuing problem.

Bromide abuse: a continuing problem.


Psychiatry and the law: changing the system through changing the training.


The effect of a psychiatric residency program on admission and discharge rates and patient disposition.


The Capgras syndrome and its psychopathology.


Psychiatric illness and season of birth.


Letter: The ethics of behavior control.

Letter: The ethics of behavior control.


Letter: "Digitalization" versus "neuroleptization".


Letter: Screening of encounter group participants.


Letter: Self-disclosure by the therapist.


Letter: Goals of psychoanalysis.

Letter: Goals of psychoanalysis.


Letter: In defense of "tender loving care".


Letter: Tricyclic antidepressants and suicide.


Effect of ascorbic acid on serum cholesterol levels and on die-away curves of 14C-4-cholesterol in baboons.


Liver function in the pig. Total hepatic and portal flow values in vivo.


Massive liver cell necrosis induced in the pig with carbon tetrachloride.


Aspiration pneumonia. Prevention of aspiration in patients with tracheostomies.


Operative treatment of massive hemoptysis.


Open-heart surgery in patients more than 65 years old.


Traumatic aneurysms of the thoracic aorta. Report of 43 patients.


The use of a cuffed endotracheal tube for repair of operative injuries to the atria.


Editorial: Continuing medical education and professional competence.


Editorial: The Cuban physician.

Editorial: The Cuban physician.


Editorial: Medical writing.

Editorial: Medical writing.


Compression of lacrimal sac by inverted papilloma arising in the maxillary sinus.


The acceptance of a family planning clinic by recently delivered teen-agers.


Carcinoma of the lip.

Carcinoma of the lip.


Peripheral joint imaging in juvenile rheumatoid arthritis.


Malignant hyperthermia.

Malignant hyperthermia.


Breast cancer and vocal cord paralysis.

Breast cancer and vocal cord paralysis.


Chlorprothixene therapy for herpes zoster neuralgia.


Xeroradiography: nonmammographic applications.


Tietze's syndrome at the xiphisternal joint.


Massive pulmonary embolism: a plan of medical management.


Writing for each other.

Writing for each other.


The Cuban physician in the United States.


Neonatal coccidioidomycosis in a southwestern Pima Indian.


Spontaneous spinal epidural hemorrhage.

Spontaneous spinal epidural hemorrhage.


Adenocarcinoma of the colon presenting as Clostridium septicum cellulitis of the left thigh.


Hypoalbuminemia, ascites, and pseudomembranous colitis after clindamycin therapy.


A massive pulmonary hemorrhage resulting in cavitation occurring in a case of hemophilia A associated with diabetes mellitus.


Sudden infant death. Normal cardiac habituation and poor autonomic control.


Factors predisposing to bacteriuria during indwelling urethral catheterization.


Chronic hepatic encephalopathy treated with oral lactose in a patient with lactose malabsorption.


Cervical venous hums in patients on chronic hemodialysis.


Elevated plasma procaine concentrations after administration of procaine penicillin G.


The three-layered cake--a plan for physician compensation.


Letter: Premature screening for hypertension.


Letter: Diagonal ear-lobe crease as a coronary risk factor.


Letter: Fatal hemorrhage from Swan-Ganz catheter.


Letter: Pulmonary embolism in hereditary thrombocytopenia.


Letter: Unavailability of iron in Gaucher's cells.


Letter: Water and solute movement through cell membranes.


Pediatric multipurpose intensive care unit.


A bedside washout technique for atelectasis in infants.


Patient flow in pediatrics. Private practive vs the pediatric clinic.


Childhood infections. Diagnostic value of peripheral white blood cell and differential cell counts.


The idiopathic nephrotic syndrome of childhood. A clinical reevaluation of 148 cases.


Nitro blue tetrazolium dye reduction test in children after cardiac surgery.


Pneumatocele formation following hydrocarbon pneumonitis. Radiological case of the month.


Tetralogy of Fallot with right aortic arch in three successive generations.


Familial renal dysplasia with sodium wasting and hypokalemic alkalosis.


Diabetes mellitus following mumps. Insulin reserve.


Emotional deprivation. Report of a case with features of leprechaunism.


Letter: Intracranial arterial occlusion in children.


The Mauriac syndrome.

The Mauriac syndrome.


Letter: The Russell-Silver syndrome.

Letter: The Russell-Silver syndrome.


Letter: Spontaneous, lower-extremity venous thrombosis in children.


Cancer, autoimmunity and IgA-deficiency related by a common antigen-antibody system.


Altered metabolism of carcinoembryonic antigen in hamsters bearing GW-39 tumours.


Subunit structure of H-2 alloantigens.

Subunit structure of H-2 alloantigens.


New biological activity following intravascular activation of the complement cascade.


Plus and minus-bicuculline methochloride as optical isomers of a GABA antagonist.


Photophosphorylation of an ADP analogue by spinach chloroplasts.


Letter: Bovine thymin.

Letter: Bovine thymin.


Etiology and treatment of dysfunctional uterine bleeding.


The ovulatory cycle. A histologic, thermal, steroid, and gonadotropin correlation. Relationships of the day of thermal nadir, day of estradiol peak, and day of LH peak to the endometrium and corpus luteum dating system were studied.  Blood samples and rectal basal body temperatures were obtained daily during an ovulatory cycle from 8 healthy women who requested tubal ligation or tubal reconstruction.  The tubal surgery was performed at planned intervals (1-12 days) after the luteinizing hormone (LH) peak.  Endometrium and corpus luteum biopsies were taken at the same time.  Daily blood samples were analyzed for plasma estrone, estradiol, progesterone, follicle stimulating hormone and LH by radioimmunoassay.  The correlation of corpus luteum and endometrial dates was .97.  Correlations were made between endometrial dates and time of thermal nadir (.97).  Correlations were also made between corpus luteum date and time of thermal nadir (.96), time of the estradiol peak (.9) and time of the LH peak (.93).  There was histologic evidence of ovulation during the 24-hour time period designated as Day 0.


Serum progesterone values in the luteal phase defects. Effect of chorionic gonadotropin.


Hyperthecosis syndrome.

Hyperthecosis syndrome.


Primary amenorrhea in a 46,XX-46,XXq-female.


Urinary excretion of steroids in a case of hydatidiform mole with ascites.


Use of progestational agents in endometrial adenocarcinoma. Since 1963 there have been 266 patients with cancer of the uterine fundus at the Medical University of South Carolina.  Progestational agents were used to treat 54 but 10 received the drugs for less than 1 month.  This report relates to the remaining 44.  34 were treated with Depo-Provera (medroxyprogesterone acetate), 9 with Colprone (megestrone acetate), and 1 with Megace (megestrol acetate).  Of the 34 patients treated with Depo-Provera 13 showed regression of the tumor; 3 of the 9 treated with Colprone showed regression.  In an additional 11 (25%) of cases growth of the tumors was arrested.  7 of these were later found to have abdominal metastases; however, 3 were free of symptoms for over 43 months.  A patient on Depo-Provera with lung metastases had recurrence after 62 months when treatment was reduced to every other week but when Colprone was then given, regression again occurred and has continued for almost 10 years.  Another patient not responding to Depo-Provera did respond to Colprone.  Average duration of regression was 27.7 months, of survival 31.1 months.  Arrest of growth was 25 months in some; survival averaged 23.4 months.  (The 1 Megace case was in this group.)y Those having progression of tumors lived an average of 9 months with the longest survival 24 months.  Of the responders 8 lived from 44 to 111 months and 5 remain alive, 4 now showing no evidence of the cancer.  Tumors with well-differentiated, slow-growing lesions were most likely to respond.  Site of recurrence did not seem to influence the response.  No contraindications were found to use of progestational agents in this type of cancer.  Local reactions to the injections were few.  Subjective response was frequent even though progression was taking place.


Carcinoma of the cervix. Clinical experience during a 10-year period 1958-1967.


Endocervical changes with the use of synthetic steroids. Histologic observations of patients who exhibited cervical ectropion and colposcopic changes of vascular congestion and increased mucous secretion were made.  73 cervical biopsies were obtained from patients with normal cycles, and 106 endocervical biopsies were obtained from patients being treated with combined synthetic steroids.  6 of the 73 cervical biopsies showed epidermoid metaplasia of the surface epithelium whereas 21 of the 106 endocervical biopsies showed partial metaplasia of the surface epithelium, a significant difference (p less than .05).  2 of the 106 showed adenomatoid hyperplasia.  This study indicated that the changes induced by synthetic steroids when at their maximum are equaled under no other circumstances, even during pregnancy.


Sirenomelia. Report of a case with thoughts on the teratogenetic mechanism.


Multiple gestations of high fetal number.


Typhoid fever complicating pregnancy.

Typhoid fever complicating pregnancy.


Pregnancy characteristics of intrauterine growth retardation.


Plasma hormone profiles following high-dose intraamniotic prostaglandin F2alpha.


Effects of prostaglandin F2alpha on human corpora lutea. An enzyme histochemical, ultrastructural, and hormonal study.


Editorial: Clarification of the policy on dual publication.


Therapeutic abortion and concurrent vaginal tubal ligation.


Letter: Case of the "missing strings".

Letter: Case of the "missing strings". A method of removing an IUD whose strings may be lost is discussed.  Having identified the intrauterine location of the IUD by touch with probe, a second Lippes loop was placed and the long strings not trimmed at all.  When the patient returned later the most recently placed loop was removed and the strings of the first loop became visible; the extraction of the loop was very easy.  The author feels that the above method is innocuous and entails a minimum of discomfort and expense.  If this method were to be used in the case of loops with lost strings instead of surgery, the savings in hospital costs would be a minimum of a half million dollars.


Letter: Post-stilbestrol syndrome.

Letter: Post-stilbestrol syndrome.


Letter: Midtrimester abortion.

Letter: Midtrimester abortion. Recently there has been dissatisfaction with current methods for accomplishing midtrimester abortion.  This article reviews the results with a simple technique which apparently produces excellent results.  This involves removal of as much amniotic fluid as possible and replacement of the volume with a greater amount of hypertonic saline.  In later cases no fluid was removed.  No uterine stimulants were used in any of the cases prior to delivery.  Not removing amniotic fluid seems to have the advantage of allowing infusion of a large amount of concentrated saline without danger of toxicity and at the same time expanding the amniotic cavity to get maximum contractility.


Presidential address: Creating the future.


The case for psychiatric hospitalization.


Independent examination of patients hospitalized against their will.


A 10-year follow-up of 55 hospitalized adolescents.


Evaluating the competence of trainees: it's nothing personal.


The coping behavior of Nazi concentration camp survivors.


Mental patients' perceptions of illness etiology.


Does lithium block the effects of amphetamine? A report of three cases.


Applying principles of instructional design to a medical school course in psychiatry.


Pathological grief following spontaneous abortion.


The questionable relationship between homicides and the lunar cycle.


Letter: Feedback on abortion consultation. The author agree's with C.M. Friedman's article ("Making Abortion Consultation Therapeutic," November 1973) that psychiatrists should stop prostituting themselves by claiming an abortion is necessary to safeguar d the woman's mental health.  However, he feels the real human issue is whether a lift whould be destroyed simply because it is inconvenient for the mother and not, as Dr. Friedman suggests, because of "her mature longings for a child, her present capacity to love and  give, her present reality, and a weighing of her morality."


Letter: Wives of homosexual men.

Letter: Wives of homosexual men.


Letter: Psychogenic impotence.

Letter: Psychogenic impotence.


Collagen from frozen fractured glycerinated beef heart.


Interactions of troponin subunits with different forms of tropomyosin.


The subplasmalemmal microfilaments in Kupffer cells.


Tubular structures in endoplasmic reticulum of cultured broccoli.


Ultrastructure of the crystalline inclusion induced by tobacco etch virus visualized by freeze-etching.


Transfer cells in traps of the carnivorous plant Utricularia monanthos.


The fine structure of the chloroplast nucleoid in Scrippsiella sweeneyae (Dinophyceae).


Hereditary renal tubular acidosis. Report of a 64 member kindred with variable clinical expression including idiopathic hypercalciuria.


Joint manifestations of sickle cell disease.


Gallium scanning in acute hepatic amebic abscess.


Plasma insulin in patients with myotonic dystrophy and their relatives.


Renal uptake of 99mTc-sulfur colloid.

Renal uptake of 99mTc-sulfur colloid.


Studies of acute cardiopulmonary toxicity of Sn-macroaggregated albumin in the dog.


Radionuclide evaluation of regional lung function in children.


Evaluation of 133Xe techniques for measurement of regional ventilation.


A rapid method for measurement of fractional intestinal absorption of calcium.


The significance of the liver-spleen uptake ration in liver scannning.


Regional lung volume measurement by transmission scintigraphy.


A 99mTc-labeled replacement for 131-I-rose bengal in liver and biliary tract studies.


The clinical limitations of brain scanning in metastatic disease.


False-positive 75Se-selenite scan in nonmalignant lesions.


Differential vital capacity determinations with radioactive xenon.


Scan demonstration of delayed splenic rupture.


Lacrimal gland accumulation of 67Ga.

Lacrimal gland accumulation of 67Ga.


Diminished cerebral perfusion resulting from kinking of the internal carotid artery.


Radionuclide diagnosis of pulmonary sequestration.


Cerebral hematoma with intraventricular bleeding.


Positive brain scan in toxoplasmosis.

Positive brain scan in toxoplasmosis.


Letter: 169Yb-DTPA cisternography: how many rads does the brain receive?


Effects of glucose on bicarbonate reabsorption in the dog kidney. The effects of glucose on renal bicarbonate reabsorption were investigated in the dog. The infusion of small amounts of glucose calculated to slightly exceed the renal threshold for glucose absorption increased bicarbonate reabsorption in bicarbonate loaded dogs. Galactose in similar doses also increased the reabsorption of filtered bicarbonate. This effect is not due to insulin secretion since insulin alone did not alter bicarbonate reabsorption and the infusion of glucose into alloxan-diabetic dogs given a steady infusion of insulin also enhanced bicarbonate reabsorption. It is more likely that the increased tubular reabsorption of glucose, secondary to an increased filtered load, resulted in the increase in bicarbonate reabsorption since phlorizin reversibly inhibits the effect of glucose.


Pressure control of sodium reabsorption and intercellular backflux across proximal kidney tubule. The magnitude of changes in luminal hydrostatic pressure (DeltaP(L)), peritubular capillary hydrostatic pressure (DeltaP(PT)), and peritubular capillary colloid osmotic pressure (Deltapi) was determined in the Necturus kidney during volume expansion (VE). The specific effects of separate changes of each pressure parameter on proximal net sodium transport (J(Na)) were studied in isolated perfused kidneys. The combined effect of DeltaP(L), DeltaP(PT), and Deltapi, of a magnitude similar to that induced by volume expansion, decreases J(Na) by 26% in the perfused kidney. A major portion of the natriuresis in VE is due to changes in intrarenal pressures. The effect of Deltapi on the permeability characteristics of Necturus proximal tubule was studied. With increasing Deltapi, the ionic conductance of the paracellular shunt pathway decreased, since transepithelial input and specific resistance rose significantly, whereas cellular membrane resistance remained unchanged. Transepithelial permeability coefficients for sodium chloride and raffinose changed inversely proportional to transepithelial resistance, indicating an alteration of a paracellular permeation route. Net passive sodium backflux and active transport flux components were calculated. Increased net sodium transport with rising Deltapi is accompanied by a significant drop in passive back diffusion, without an increment in the active flux component. Change in passive sodium ion back diffusion thus appears to be a key physiological factor in the control of transepithelial sodium transport.


Phospholipid metabolism in the initiation of renal compensatory growth after acute reduction of renal mass. Membrane metabolism was studied during the initiation of compensatory growth after acute reduction in renal mass. The rate of [(14)C]choline incorporation into phospholipid in renal cortical slices was increased by 37% at 5 min of compensatory growth in mice. The rate increased to the maximal value of 68% by 20 min and remained there for 3 h. The rate then remained increased at 28-34% above normal for 2 days and returned to normal by the 6th day. The increase in rate of choline incorporation into renal phospholipid was independent of choline uptake. [(14)C]Choline was found to be a specific precursor of the three renal phospholipids, phosphatidylcholine, lysophosphatidylcholine, and sphingomyelin, which comprise over half the amount of the phospholipids. The relative distribution of the label in each of the three phospholipid classes did not change with compensatory growth. An increased rate of choline incorporation was also observed in kidneys of rats during compensatory growth and in the compensating kidneys of mice treated with indomethacin before uninephrectomy. The rate was increased 24% at 3 h after uninephrectomy in vivo. The increase appeared to be specific for the kidney, since it did not occur in the livers of these mice. The results indicate that the onset of renal compensatory growth is associated with a specific enhancement of the synthesis of renal choline-containing phospholipids. Since the phospholipids largely occur in the cell membrane, early alterations in cell membrane metabolism may thus play a role in the initiation of cell growth.


Dermatitis herpetiformis. Immunologic concomitants of small intestinal disease and relationship to histocompatibility antigen HL-A8. In the present study the relation between the gluten-sensitive intestinal lesion observed in dermatitis herpetiformis (DH) and in gluten-sensitive enteropathy (coeliac sprue) (GSE) was analyzed. Jejunal IgA synthesis in DH was estimated from the extent of incorporation of [(14)C]leucine into IgA in jejunal biopsy specimens during short-term in vitro culture. Patients with DH have significantly elevated incorporation values as compared to normal control individuals (18,880+/-13,614 vs. 5,830+/-3,190 cpm/mg tissue protein/ 90 min) (P < 0.02) and the degree of elevation correlates well with the degree of morphologic abnormality. Thus patients with DH are similar to patients with GSE where elevated local mucosal IgA synthesis has also been observed. By using both morphologic and immunologic criteria for evaluating intestinal status, patients with DH and intestinal disease were distinguished from patients with DH free of intestinal disease. Of the eight patients in the former group, seven carried HL-A8 (87.5%), an incidence which is strikingly similar to that observed in patients with GSE alone (88.5%). In contrast, of the seven patients in the latter group (without gastro-intestinal disease) two had HL-A8, an incidence (27%) not significantly different from that in the normal population (20%) (P > 0.1).Thus, both in respect to local mucosal increase in IgA synthetic rates and in respect to the association with HL-A8, the intestinal lesion of DH is similar to that of GSE.


Glutamine transport in rat kidney mitochondria in metabolic acidosis. In order to study factors regulating renal ammoniagenesis, the transport and metabolism of L-glutamine were studied in mitochondria from kidneys of control and acidotic rats. On incubation in 1 mM [(14)C]glutamine, there was production and accumulation of [(14)C]glutamate within the matrix space. However no [(14)C]glutamine was detected in the matrix space, even with 10 mM [(14)C]glutamine as substrate or with inhibition of glutamine deamidation (low temperature, p-chloromercuribenzoate, mersalyl). These results suggest that glutamine crosses the inner membrane by a carrier-mediated step and that this step is rate-limiting in glutamine deamidation. In chronic acidosis there is a fourfold increase in the uptake of radioactivity from [(14)C]glutamine, but not from alpha-ketoglutarate, glutamate, or acetate. In 3-h acidosis, before any increase in extracted glutaminase levels, there is a significant and reproducible increase (39+/-3.8%, n = 25) in matrix uptake of radioactivity from [(14)C]glutamine and also an increased ammonia production (17+/-3.7%, n = 12). Administration of furosemide produces a similar degree of potassium depletion and a greater degree of sodium depletion over 3 h when compared to a 3-h acidosis. However, it produces no change in mitochondrial uptake of radioactivity. These results show that the adaptation of renal glutamine metabolism observed in acidosis is due to the acidosis and is demonstrable in isolated rat kidney mitochondria. The site of adaptation is in the carrier system, which transports glutamine across the inner membrane. The increased transport in acidosis delivers more glutamine to glutaminase, which results in the increased renal ammonia production.


Immunoreactive forms of circulating parathyroid hormone in primary and ectopic hyperparathyroidism. The immunoreactive forms of parathyroid hormone (iPTH) in the plasma of six patients with primary, adenomatous hyperparathyroidism and six patients with ectopic hyperparathyroidism due to non-parathyroid cancer were compared by using gel filtration on columns of Bio-Gel P-150 and radioimmunoassay of iPTH in eluted fractions after concentration. We found much less (p<0.001) small (mol wt<9,500) COOH-terminal fragments of iPTH in plasma samples from ectopic hyperparathyroid patients (0.52+/-0.13 ng eq/ml) than in samples from primary hyperparathyroid patients (3.70+/-1.15 ng eq/ml). The quantity of iPTH eluting with or before native bovine PTH [1-84] was the same in both syndromes (ectopic hyperparathyroidism, 0.82+/-0.22 ng eq/ml; primary hyperparathyroidism, 0.73+/-0.09 ng eq/ml), and these values correlated positively with plasma calcium concentration (ectopic hyperparathyroidism, r=0.908; primary hyperparathyroidism, r=0.919). In both syndromes, plasma samples had an iPTH component that eluted well before PTH [1-84] (mol wt 9,500), but this component was present in much larger quantities in three patients with ectopic hyperparathyroidism. We conclude that (a) the decreased quantity of biologically inactive COOH-terminal fragments of iPTH circulating in ectopic hyperparathyroidism accounts for the previously reported relatively lower total serum iPTH values in this syndrome as compared with primary hyperparathyroidism (Riggs et al. 1971. J. Clin. Invest. 50: 2079); (b) there appears to be sufficient iPTH with presumed biologic activity to account for the hypercalcemia in both syndromes; (c) a large PTH component, not previously recognized in plasma, is present in both ectopic and primary hyperparathyroidism and may exist as the predominant immunoreactive form of the hormone in some patients with ectopic hyperparathyroidism.


Cysteine activation in cultured cystinotic cells. The specific activity of cysteinyl-tRNA synthetase and tRNACys and the determination of the Michaelis-Menten constants for cysteinyl-tRNA synthetase. This study explored the possibility whether an altered cysteinyl-tRNA synthetase might lead to the faulty regulation of cyst(e)ine levels in cystinotic cells. This hypotheses is attractive, since amino acid activation is important in the regulation of amino acid metabolism in microorganisms. By using cultured fibroblasts from patients with cystinosis, those cell components responsible for cysteine activation were examined: cyst(e)ine, the cysteinyl-tRNA levels, cysteinyl-tRNA synthetase activity, and the K(m) of cysteine, ATP, and tRNA(Cys) for cysteinyl-tRNA synthetase, Fibroblasts from two patients with the infantile form of cystinosis were labeled for three days with [(35)S]-cystine. In comparison with normal cells, these cells contained high levels of free cysteine and cystine. Labeled fibroblasts from a patient with the adolescent form of the disease contained elevated levels of cystine, although elevated cysteine levels were not detected. The ratio of acceptor activity of tRNA(Cys) to tRNA(Leu) in cystinotic cells was 0.46 in cystinotic cells and 0.54 in normal cells. The specific activity of cysteinyl-tRNA synthetase measured in fibroblasts of two infantile and one adolescent form was: 6.1, 2.2, and 2.1 pmol of [(14)C]aminoacyl-tRNA formed/mug protein/10 min, respectively. In addition, the cysteine K(m)'s for the same cells, respectively, were: 3.1 muM, 1.5 muM, and 1.2 muM. The corresponding data for specific activities of two normal cell lines were 2.0 and 5.1 pmol [(14)C]aminoacyl tRNA formed/mug protein/10 min, with K(m)'s of 3.0 muM and 1.7 muM. These data indicate that cystinotic cells contain levels of tRNA(Cys) and Cys-tRNA synthetase comparable to normal cells. In addition, within the cystinotic cells, the relative level of the Cys-tRNA synthetase and tRNA(Cys) to those of leucine and alanine are comparable to normal cells. Finally, the K(m) of Cys-tRNA synthetase for ATP and tRNA is similar in normal and cystinotic cells.


Hepatic autography in uncontrolled experimental diabetes and its relationships to insulin and glucagon. Exogenous glucagon is known to increase hepatic lysosomes, but the relationships between endogenous glucagon and insulin levels and hepatic lysosomes have not been examined. To determine if the hormones of the pancreatic islets influence the development of these organelles glycogenosomes, dense bodies, and autophagosomes were morphometrically quantitated in normal rats, in rats with mild streptozotocin diabetes with normal hormone levels, and in rats with severe streptozotocin diabetes with hyperglucagonemia, hypo-insulinemia, and clinical evidence of uncontrolled diabetes and ketoacidosis. In the latter volume density of lysosomes averaged 222.8x10(-4) (SEM +/-19.8x10(-4)), significantly above the control value of 75x10(-4) (SEM +/-7.0x10(-4)) (P<0.0005); glycogenosomes were absent in the diabetics, the increase being largely the result of increased autophagosomes. Insulin treatment corrected the hyperglucagonemia, hypoinsulinemia, and other manifestations of uncontrolled diabetes and reduced the volume density of lysosomes to 37.4x10(-4) (SEM +/-2.0x10(-4)), significantly below both the untreated diabetic rats and the nondiabetic controls (P<0.0025). In mild streptozotocin diabetes, in which hyperglucagonemia, hypoinsulinemia, and other evidence of uncontrolled diabetes were absent, lysosomes averaged 77.6x10(-4) (SEM +/-5.5x10(-4)), not different from the controls. A statistically significant correlation between all measurements of lysosomal volume density and plasma glucagon was observed (r=0.79; P<0.001). It is concluded that uncontrolled streptozotocin diabetes in rats is accompanied by hepatic autophagy which may be related to the increased plasma glucagon level and/or the decreased insulin and which is corrected by insulin therapy.


Elevation of plasma neurophysin in women on oral contraceptives. The effect of oral contraceptives on the neurohypophysis was demonstrated by changes in the plasma level of a posterior pituitary protein. neurophysin. Neurophysins are intraneuronal proteins associated with oxytocin and vasopressin. They have been shown to be released into the bloodstream. The resting plasma level of neurophysin in normal nonpregnant women is 0.69 ng/ml+/-0.7 SD. In women on oral contraceptives, the plasma level is 6.4 ng/ml+/-4.2 SD (P<0.001). Estrogen rather than progesterone causes the elevated neurophysin. The effect is observed within 12-24 h of estrogen administration and disappears 3-11 days after estrogen is discontinued. The results indicate that oral contraceptives act on the neurohypophysis and that estrogen is a potent pharmacologic stimulus useful in studying synthesis and release of neurophysin.


Lung tissue elastin composition in newborn infants with the respiratory distress syndrome and other diseases. Amino acid analysis of human fetal lung elastin was undertaken in 49 instances of live-born neonates, ranging from 380 g to full term, and in 3 abortuses of 12-14 wk gestation. The data suggest that formation of the cross-linking agents, desmosine and isodesmosine, occurs early, between 14 and 22 wk. The ratio of neutral to charged amino acids remains low until the 36th wk when it attains adult levels. The composition of elastin was independent of sex and duration of survival. In three neonatal pulmonary diseases (respiratory distress syndrome, atelectasis, and hemorrhage) ratios were significantly lower than those found in nondiseased lungs. This may be a reflection of immaturity or may be a predisposing factor in neonatal lung disease. The latter hypothesis is attractive and receives indirect support from the association of a more polar elastin with other diseases, including adult emphysema and atheromatous aortic change.Our finding of relatively high polarity in elastin from human fetal lung is consistent with previous observations in a variety of fetal organs of other species.


Editorial: The "downwind principle" in medical clean ventilation.


Glove starch granulomatous disease. An unsolved surgical problem.


Evaporative water loss of adult surgical patients in Greece.


Identification of the wound infection-potentiating factors in soil.


Vascular access for chronic hemodialysis using modified bovine arterial graft arteriovenous fistula.


Anomalaous location of the papilla of vater.


Arterial below the knee bypass grafts. Experience with the modified bovine heterograft.


Postsympathectomy neuralgia. Amelioration with diphenylhydantoin and carbamazepine.


Popliteal artery entrapment.

Popliteal artery entrapment.


Ameloblastoma with regional and distant metastases.


A silent sponge speaks.

A silent sponge speaks.


Hormone-dependent medullary carcinoma of the thyroid.


The plastic heparin lock.

The plastic heparin lock.


Ectopic hyperparathyroidism.

Ectopic hyperparathyroidism.


Anticipating pressure necrosis in intestinal obstruction.


End to side isoaxial anastomosis in gastrointestinal surgery.


A mechanical device for costal margin retraction.


Preliminary report: Decreased leukocyte alkaline phoshatase in hyperthyroidism.


Clinical and metabolic studies of chemically defined diets in the management of obesity.


Letter: The effect of contraceptive steroids on carbohydrate metabolism. Comments are made on a short review on the effect of contraceptive s teroids on carbohydrate metabolism which appeared previously.  Intraveno us tolbutamide tolerance tests were performed on 13 normal women and 8 hypopituitary patients before and 3 and 6 months after starting on an oral contraceptive agent (OCA) containing 50 mcg mestranol and 1 mg norethindrone.  The control subjects demonstrated a significant impairment of the glucose fall after tolbutamide and an enhancement of the growth hormone (GH) response to the resultant hypoglycemia while on the OCA.  The pituitary-deficient patients showed no change in their glucose response to tolbutamide after starting OCA and they had minimal GH secretion as expected.  5 additional normal females on a variety of OCAs had a significant 3-fold increase in GH concentrations after moderate exercise as compared with 5 other women using other forms of contraception.  The peripheral tissues of women on OCAs were exposed to higher levels of GH throughout the day.  The data seemed to implicate the anterior pituitary gland, and it was postulated that the estrogen-induced secretion of GH, a potent insulin antagonist, was responsible for the effects of OCAs on carbohydrate metabolism.  It is concluded through laboratory investigations that there is good evidence to support the role of estrogens alone in causing deterioration of glucose tolerance.  This contradicts the review in which it was concluded that carbohydrate metabolism in younger women was unaffected by estrogens alone but will deteriorate in response to a combination of estrogen and nortestosterone progestins.


Actions of cholecystokinin and secretin on the motor activity of the small intestine in man.


Nature and kinetics of inhibition of lower esophageal sphincter pressure by glucagon.


Clearer roentgenographic visualization of the colon. A study of a conveniently packaged kit for preparing the colon, and its effect on electrolyte balance.


Effects of ouabain on intestinal oxygen consumption.


A comparison between the bile acid concentration and the inorganic cation-anion difference in dog bile.


Intermittent idiopathic portal hypertension. A case report.


An unusual form of macroamylasemia.

An unusual form of macroamylasemia.


Cystadenoma of the pancreas. Report of a case and its arteriographic diagnosis.


Letter: Antibodies to mitochondria in intrahepatic and extrahepatic cholestasis.


Letter: Inhibition of hepatic fibrosis by AZC.


Detection of Bacteroides fragilis infection by precipitin antibody.


Primary complex of Cryptococcus and pulmonary lymph nodes.


Malfunctioning tricuspid valve prosthesis. Clinical, phonocardiographic, echocardiographic, and surgical findings.


Lability of skeletal muscle magnesium in vivo. A study in red and white muscle.


Wiskott-Aldrich syndrome in an adult.

Wiskott-Aldrich syndrome in an adult.


Pulmonary arteriovenous fistulas.

Pulmonary arteriovenous fistulas.


The effect of prior pulmonary injury on the rate of development of fatal oxygen toxicity.


Effect of 48- and 72-hour oxygen exposure on the rabbit alveolar macrophage.


Oxygen toxicity and gas mixtures: morphology.


Pulmonary morphology of chronic phase of oxygen toxicity in adult rats.


Common oxidant lesion of mitochondrial redox state produced by nitrogen dioxide, ozone, and high oxygen in alveolar macrophages.


Effect of ozone exposure on lung mitochondrial oxidative metabolism.


Release of prostaglandins and other humoral mediators during hypoxic breathing and pulmonary edema.


Release of beta glucuronidase and elastase from alveolar mononuclear cells.


Functional effects of influenzal pneumonia.


Treatment of acute respiratory failure with prolonged extracorporeal oxygenation.


Renin: A risk factor for cardiovascular disease?


Nasal mucous membrane biopsy in Sjogren's syndrome. A new diagnostic technique.


Synovial fluid complement: usefulness in diagnosis and classification of rheumatoid arthritis.


Prognosis of advanced chronic renal failure. 1. Unpredictability of survival and reversibility.


Cessation of paroxysmal supraventricular tachycardias by parasympathomimetic interventions.


ST-Segment alternans in Prinzmetal's angina. A report of two cases.


The internship and residency application hassle.


Polymer fume fever and cigarette smoking.


Chemical structure of erythromycin and hepatotoxicity.


Letter: Sarcoidosis and hyperprolactinemia.


Letter: Testing in pheochromocytoma and another endocrine tumor.


Letter: Atropine and bradycardia after myocardial infarction.


Letter: Calcium-binding protein in hypophosphatemic osteomalacia.


Letter: Rapidly progressive aortic insufficiency in Reiter's syndrome.


Letter: Trial of nurse practitioners.

Letter: Trial of nurse practitioners.


Letter: Atropine and infarction bradycardia.


Letter: Serum digoxin and thyroid hormones.


Letter: Hypercalcemia and neuromuscular disease.


Letter: Chloride:phosphate ratio in hypercalcemia.


Letter: Hemolysis and pancytopenia in ethchlorvynol overdose.


Letter: Thrombocytopenia and iron deficiency.


Letter: Airway obstruction and somnolence.


Comparative clinical pharmacology of three ampicillins and amoxicillin administered orally.


Treatment of enterococcal endocarditis with oral amoxicillin and intramuscular gentamicin.


Drowning and near-drowning.

Drowning and near-drowning.


How immune are our teenagers?

How immune are our teenagers?


Tomography in urologic diagnosis.

Tomography in urologic diagnosis.


Ulcer disease in the elderly.

Ulcer disease in the elderly.


Minimal brain dysfunctions in children.

Minimal brain dysfunctions in children.


Laxatives and fecal modifiers.

Laxatives and fecal modifiers.


Nonsurgical treatment of subdural hematomas.


The surface characteristics of arachnoid granulations.


Ultrastructure of brain and nerve biopsy tissue in Wilson disease.


An experimental model for the study of hepatic encephalopathy.


Familial hypokalemic periodic paralysis.


Creatine phosphokinase isozymes in neuromuscular disorders.


Optokinetic asymmetry in internuclear ophthalmoplegia.


Carbidopa in Parkinson disease and in nausea and vomiting of levodopa.


Special issue on mammary and apocrine glands. Proceedings of the 23rd annual symposium on the biology of skin. Preface.


Proceedings: Some neglected aspects of the anatomy of human breasts.


Proceedings: Electron microscopic study of functional and dysfunctional human mammary glands.


Proceedings: Breast deformities and their surgical repair.


The physician's responsibility in the management of sudden infant death syndrome.


Proceedings: The ultrastructure of human axillary apocrine glands after epinephrine injection.


Iron deficiency in families of iron-deficient inner-city school children.


Progressive encephalopathy due to chronic hydantoin intoxication.


Sickle cell "nondisease". A potentially serious public health problem.


Clinical staging in Reye syndrome.

Clinical staging in Reye syndrome.


The medical care of children at summer camps. An evaluation of 1,412 infirmary visits.


Acute dissecting aneurysm of the aorta secondary to a stenotic aortic valve and cystic medial necrosis. Radiological case of the month.


XO and male phenotype.

XO and male phenotype.


Angiomatous lymphoid hamartoma in an infant.


Extensive genitourinary anomalies associated with Klippel-Feil syndrome.


Pancreatic acinar cell carcinoma in childhood.


Solitary keratoacanthoma in a child.

Solitary keratoacanthoma in a child.


Idiopathic bell palsy in a 2-month-old child.


Letter: Low-set ears.

Letter: Low-set ears.


Letter: The Ullrich-Noonan syndrome.

Letter: The Ullrich-Noonan syndrome.


Letter: Aspirin-induced abnormalities of liver function.


Letter: The levodopa test of growth hormone reserve in children.


Infant feeding.

Infant feeding.


Neonatal intensive care. 1. Regional needs and planning.


Management of the solitary parotid mass.


Cardiac tumors.

Cardiac tumors.


Dialogue: Complications of aortic valve replacement.


Fever, vomiting, and liver dysfunction with procainamide therapy.


Editorial: Therapeutic uses of hydrophilic lenses.


The electroretinogram of children deprived of pattern vision.


Microangiography of the rabbit eye: a radiographic study.


Tear lactoferrin: a bacteriostatic and complexing protein.


Pharmacodynamic response in nonocclusive mesenteric ischemia.


Threshold burning effects on distant microcirculation: Presence of a passively transferrable, nondialyzable arteriolar constrictor substance in blood of burned patients.


Venography and pulmonary arteriography: Essential definitive studies for thromboembolic disease.


Thrombosis of the popliteal artery caused by a neurinoma of the common peroneal nerve.


Subclavian vein catheterization: Comparison of standard technique and a tunneled technique.


Use of the doppler ultrasonic flowmeter to monitor blood pressure during ileal loop bypass for extreme obesity.


Villous adenoma: the premalignant dilemma.


Solitary liver abscess as a complication of sigmoid diverticulitis.


Unusual complications with use of silastic dural substitute.


Strangulated traumatic diaphragmatic hernia: A case report.


The roentgen diagnosis of renal inflammatory masses--special emphasis on angiographic changes.


Massive injection of contrast medium into a renal artery segment. Case report.


Angiographic evaluation of pancreatic disease. A further appraisal.


Percutaneous transhepatic cholangiography.


Angiographic findings in patients with choledocholithiasis and obstructive jaundice.


Nonopacification of the gallbladder and bile ducts. A previously unreported cause.


Automated ventricular volume calculations from single plane images.


Hemorrhage following percutaneous lung biopsy.


Spigelian hernias: anatomy and roentgenographic manifestations.


A statistical comparison study of patients undergoing breast biopsy at a community hospital over a 16-year period.


The application of computer simulation modeling to the radiology film library.


The posterior choroidal arteries. Normal measurements and displacement by hydrocephalus or tumors of the pineal region or brainstem.


Cerebral angiography in the diagnosis of orbital rhabdomyosarcoma.


Cauda equina compression in acromegaly.

Cauda equina compression in acromegaly.


Review of solitary 18F bone scan lesions.


18F bone scanning: review of indications and results of 1,500 scans.


Quantitation of cerebrospinal fluid shunt flow.


Brain scans in infantile cerebral paralysis.


Venous thrombosis in infants and children.


The role of transverse axial tomography in three-dimensional treatment planning.


Kinky hair syndrome: serial study of radiological findings with emphasis on the similarity to the battered child syndrome.


Splenic irradiation portals.

Splenic irradiation portals.


Aerosol inhalation in lung imaging.

Aerosol inhalation in lung imaging.


Radiation-induced changes in pulmonary perfusion.


Changes in pulmonary compliance and production of fibrosis in x-irradiated lungs of rats.


In vivo quantitation of radioactivity using the Anger camera.


Distal penetration in radioaerosol inhalation with an ultrasonic nebulizer.


Myocardial imaging using 43K and the gamma camera.


Editorial: Radiology residency approval: desirability of feedback from the American Board of Radiology Examinations.


Observation of bronchial dynamics by means of an intraluminal induction gauge.


Radiological Society of North America. 1974 Refresher course: Postgraduate instruction and radiologic round tables for residents (RRR).


Epithelial downgrowth after surgery for epithelial cyst.


Cell-mediated immunity to a retinoblastoma tissue culture line in patients with retinoblastoma.


Primary orbital melanoma.

Primary orbital melanoma.


Lymphocyte transformation in Bantu-speaking Negroes with endogenous uveitis.


Sclerocornea with an unbalanced translocation (17p, 10q).


Blindness caused by diabetic retinopathy.


Sclerocornea associated with Dandy-Walker cyst.


Electron microscopy of cornea and conjunctiva in childhood cystinosis.


Intravitreal amphotericin B toxicity.

Intravitreal amphotericin B toxicity.


Development of sympathetic uveitis in spite of corticosteroid therapy.


Anterior polar cataracts.

Anterior polar cataracts.


Cytotoxicity of ophthalmic preservatives.


Tear and serum immunoglobulin levels in Navajo children with trachoma.


Intraocular pressure measurement in infants under general anesthesia.


Conventional occlusion vs. pleoptics in the treatment of amblyopia.


Clinical-angiographic correlations in amaurosis fugax.


Cholesterolosis of the anterior chamber.


The black dot sign and North American cutaneous blastomycosis.


Letter: Central serous retinopathy and pregnancy.


B-scan ultrasound in the evaluation of renal mass lesions.


Flank pain and hematuria in a young man with renal artery arteriosclerosis: remission of symptoms during administration of dipyridamole.


Verification and quantification of anatomic arteriovenous shunting in a hypernephroma.


Myelolipoma of the kidney.

Myelolipoma of the kidney.


Leiomyoma of the kidney.

Leiomyoma of the kidney.


Two malignant soft tissue tumors of the kidney: an ultrastructural appraisal.


Retroperitoneal fibrosis and ergot derivatives.


Management of ureteral calculi: series of 574 cases with special emphasis on use of Davis loop extractor.


Clinical experience with loop nephrostomy for urinary diversion.


Clinical experience with the Mentor bladder stimulation. I. Patients with upper motor neuron lesions.


Secondary urinary reconstruction: use of the ileocecal segment.


Pudendal neurectomy in neurogenic bladder.


A clinicopathologic study of squamous cell carcinoma of the bladder.


Control of life-threatening vesical hemorrhage by unilateral hypogastric artery muscle embolization.


The clinical significance of carcinoma in situ of the bladder and its association with overt carcinoma.


Experience with transurethral external sphincterotomy in patients with spinal cord injury.


Priapism: evaluation of treatment regimens.


The testis in Cushing's syndrome.

The testis in Cushing's syndrome.


Vasovasostomy: past, present and future.


The abdominal aortic aneurysm and the urologist.


Traumatic renal hemorrhage treatment by arterial embolization.


An unusual radiologic finding in a patient with chyluria.


Experience with the Sober ureterostomy.

Experience with the Sober ureterostomy.


Pulmonary leiomyosarcoma associated with an arteriovenous fistula.


Sudden death and the ballooning posterior leaflet syndrome. Detailed anatomic and histochemical investigation.


Blood reflow after renal ischemia. Effects of hypertonic mannitol on reflow and tubular necrosis after transient ischemia in the rat.


Radiation-induced carcinoma of the rectum. A late complication of pelvic irradiation.


Letter: Glomoid lesions.

Letter: Glomoid lesions.


Circulating carcinoembryonic antigen levels and serum suppression of phytohemagglutinin-stimulated lymphocyte DNA synthesis: an inverse correlation in the cancer patient.


Studies of intestinal metaplasia in the gastric mucosa by detection of disaccharidases with "Tes-Tape".


Inhibition of leukocyte migration by tumor-associated antigens in soluble extracts of human breast carcinoma.


Cervical cancer in Yugoslavia. II. Epidemiologic factors of possible etiologic significance.


Nitrite in human saliva. Its possible relationship to nitrosamine formation.


Influence of tumor size and surgical resection on cell-mediated immunity in mice.


Prevention of friend virus leukemogenesis by concanavalin A. I. Detection of dormant virus and role of humoral antibody in protected mice.


Differentiation in vitro of normal mouse embryos and mouse embryonal carcinoma.


Sequential events in induction of sarcomas by 4-hydroxyaminoquinoline 1-oxide: fibroplasia, a premalignant phase.


Suppression of in vivo growth of mouse myelomas by purified rabbit antibodies against mouse myeloma cells.


Biochemical characterization of a cancer immunotherapeutic agent: MSF-MB.


Mammary tumorigenesis in chemical carcinogen-treated mice. I. Incidence in BALB-c and C57BL mice.


Mammary tumorigenesis in chemical carcinogen-treated mice. II. Dependence on hormone stimulation for tumorigenesis.


Carcinogenic effects of N-nitrosomorpholine and N-nitrosopiperidine on European hamster (Cricetus cricetus).


Antimetastatic effect of 4-carbethoxy-5-(3,3-dimethyl-1-triazeno)-2-methylimidazole.


Analysis of cell age distribution during ascites tumor growth.


Rat alpha 1-fetoprotein: appearance after galactosamine-induced liver injury.


Dysmyelination in "jimpy" mouse. Electron microscopic study.


Observations on the development of the Weaver mouse cerebellum.


Cerebral microgyria in a 27-week fetus: an architectonic and topographic analysis.


Extensive developmental defect of the cerebellum associated with posterior fossa ventriculocele.


Observations on myelination of human spinal cord and some effects of parturitonal transection.


An ultrastructural study of carbon disulphide induced liver injury in the rat.


Variation in the morphometry of the normal human thyroid in growth and ageing.


A hereditary dysplasia of collagen tissues in sheep.


Right heart valvular amyloidosis in a patient with duodenal carcinoid tumours.


Pregnenolone and pregnenolone sulfate metabolism in vivo and uterine extraction at midgestation.


Unconjugated estrone, estradiol and FSH and LH in prepubertal and pubertal males and females.


A defective thyroid peroxidase solubilized from a familial goiter with iodine organification defect.


The evaluation of the role of androgens in hirsutism and the use of a new anti-androgen "cyproterone acetate" for therapy.


A short calcium infusion in the diagnosis of medullary thyroid carcinoma.


Quantitative histological studies on the pathogenesis of uremic bone disease.


Measurement of serum LH, FSH, estradiol and progesterone in disorders of the human menstrual cycle: the inadequate luteal phase.


Fluctuations of gonadotropin levels in children.


Estrogen-androgen imbalance in patients with hirsutism and amenorrhea.


Inhibition by apomorphine of prolactin secretion in patients with elevated serum prolactin.


Letter: The effect of age on growth hormone secretion in man.


The effect of starvation on the concentration and binding of thyroxine and triiodothyronine in serum and on the response to TRH.


Specific, homologous radioimmunoassay (RIA) of highly purified subunits of human pituitary follicle stimulating hormone (hFSH).


Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa).


Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb).


Testicular endocrine function in a pubertal boy with 3beta-hydroxysteroid dehydrogenase deficiency.


The Endocrine Society 1974 annual awards.


Editorial: The right to choose abortion. The position of the American Pharmaceutical Association supporting the Supreme Court decision on abortion is reaffirmed and organized efforts to reverse the rulings are surveyed.  The cases of "Roe v. Wade" and "Doe v. Bolton", which were leading cases in the Supreme Court decision, are reviewed with respect to their opinions and guiding recommendations.  The positive health effects of abortion such as reduced maternal mortality rates are mentioned and it is suggested that since Catholic women aborting constitute a greater proportion of abortees compared to the proportion of Catholics in the  general population, that women of all faiths will resort to abortion if confronted with an unwanted pregnancy.


An operational and planning staffing model for first and second trimester abortion services.


Socioeconomic correlates of attitudes toward abortion in Rhode Island: 1971.


Neonatal screening for phenylketonuria. IV. Factors influencing the occurrence of false positives.


Myths and realities in international health planning.


Hemoglobinopathy screening: approaches to diagnosis, education and counseling.


Outbreak of head lice in Michigan misdiagnosed.


Red tide: a recurrent health hazard.

Red tide: a recurrent health hazard.


The source of notification in tuberculosis.


The community pharmacist: health sentinel on the home front.


Safety programs for current high output laser systems and new systems.


The buzzer-light reminder system and safety belt use.


Editorial: Legal abortion and public health.


Editorial: Preventive medicine and "natural death".


Occurrence of hepatic impairment in women jaundiced by oral contraceptives and in their mothers and sisters.


Clinical findings in patients with hypercalcaemia. A final investigation based on biochemical screening.


Acute intoxication. A comparative investigation at a General City Hospital for the years 1951, 1961 and 1971.


Morphology, dipeptidases and disaccharidases of small intestinal mucosa in chronic renal failure.


Attempted drug suicide in a Swedish city.


Intrabronchial aspiration of metallic mercury.


Statement of conference goals.

Statement of conference goals.


Investigations of coagulation and fibrinolysis in homocystinuria.


Value in the early diagnosis of cancer.

Value in the early diagnosis of cancer.


Programs and plans of the National Cancer Institute for the research and application of research methods in diagnostics to the diagnosis of cancer.


Some limitations and problems of screening for cancer.


Allied health personnel in cancer detection. Utilization of proctosigmoidoscopic technicians in detecting abnormalities of the lower bowel.


Epidemiologic basis for cancer prevention.


Epidemiologic basis of regional cancer detection programs.


Summary of the cancer prevention and detection conference, sponsored by the International Union Against Cancer, Sheffield, England 1972.


Summary and recommendations of the workshop on breast cancer.


Summary and recommendations of the workshop on lung cancer.


Summary and recommendations of the workshop on teaching cancer epidemiology and early detection in oncology training programs.


Summary and recommendations of the workshop on colon cancer.


Summary of recommendations for early detection.


The mortality of Appalachian coal miners, 1963 to 1971.


Threshold limit for carbon monoxide-induced myocardial damage: an electron microscopic study in rabbits.


The effect of illness on employment opportunities.


Short-term toxicity of mevinphos in man.


An epidemiological study of pesticide exposures in Allegheny County, Pennsylvania.


Hearing loss in adults: relation to age, sex, exposure to loud noise, and cigarette smoking.


Pressor activity in bovine kidney homogenate: enhancement by cadmium and zinc ions.


Is short-fibered asbestos dust a biological hazard?


Non-invasive technique for diagnosing congenital and acquired ventricular septal defects using directional Doppler ultrasound. Correlations with phasic flow velocity patterns of the shunt.


Complete atrial dissociation versus diaphragmatic action potentials.


Study of retrograde conduction in complete heart block using His bundle recordings.


His bundle rhythms with retrograde conduction to the atria.


Early detection of silent ischaemic heart disease by 24-hour electrocardiographic monitoring of active subjects.


His bundle recordings in paroxysmal atrioventricular block produced by carotid sinus massage.


Incidence and significance of coronary artery calcification.


Relation between fetal flow patterns, coarctation of the aorta, and pulmonary blood flow.


Electrical and mechanical aspects of left atrial activity.


Ventricular tachycardia with retrograde conduction. Simplified diagnostic approach.


Atrioventricular dissociation with prolonged QT interval and syncopal attacks in a 10-year-old boy.


The effect of trauma on colonic healing.


Pathogenesis and prevention of disruption of colonic anastomoses in traumatized rats.


Carcinoma of the male breast.

Carcinoma of the male breast.


Gastropericardial fistula--a complication of hiatus hernia.


Postoperative chest infection.

Postoperative chest infection.


Spontaneous rupture of the ureter.

Spontaneous rupture of the ureter.


Reduction in the incidence of stress incontinence complicating fistula repair.


Initial experience with Helmstein's treatment by a hydrostatic pressure technique in carcinoma of the bladder.


Popliteal aneurysm: a review of 116 cases.


A rational basis for management of patients with the Buerger syndrome.


The incidence of postoperative deep vein thrombosis in Malaysia.


Phlebography in the management of pulmonary embolism.


Wandering spleen: 11 cases from Uganda.

Wandering spleen: 11 cases from Uganda.


Fat under diaphragm simulating pneumoperitoneum.


The optimum choice of ratemeter time constant in colour scans.


Hyperinfection with Strongyloides stercoralis in Great Britain.


The estimation of bone mineral content at selected skeletal sites by gamma-ray absorption.


Potentiating effect of prior local irradiation of the lungs on pulmonary metastases.


Ovarian carcinoma metastatic to the breast.


Rib notching due to coarctation of the aorta: report of a case initially observed at less than one year of age.


Letter: Information density and bone scans.


Letter: Detection of skeletal metastases.


Correct handling of thermoluminescent LiF:teflon dosimeters.


Letter: NSD calculations--a simple graphical method.


Proceedings: The effects of radiation on solid tumours.


Proceedings: Measurements of radiation-induced cell loss using 125IUdR.


Proceedings: The effect of X rays and neutrons on tumour growth delay and cell survival.


Proceedings: The RBE for small single doses of fast neutrons for experimental tumours.


Proceedings: Optimum fractionation in X-ray treatment of C3H mouse mammary tumours.


Proceedings: The regression of tumours.

Proceedings: The regression of tumours.


Evaluation of alternative counting methods for radioimmunoassay of hepatitis-associated antigen (HB-Ag).


Factors influencing the quality of analytical methods. A systems analysis, with use of computer simulation.


Interlaboratory evaluation of proficiency testing in urinary delta-aminolevulinic acid analyses.


Comparison of four methods for determination of delta-aminolevulinic acid in urine, and evaluation of critical factors.


Fluorometric analysis for N'-formylkynurenine in plasma and urine.


Clinical evaluation of a rapid screening test for sickle cell trait (S-) and sickle cell anemia (SS).


Stability in urea as a measure of cardiac lactate dehydrogenase on the centrifugal analyzer.


Use of the simplex method to optimize analytical conditions in clinical chemistry.


Determination of unbound bilirubin in the serum of newborns.


Two ultramicro-scale methods for plasma uric acid analysis with uricase.


Mechanisms of the Liebermann-Burchard and Zak color reactions for cholesterol.


Spectral interpretation and kinetic studies of the Fe3plus--H2SO4 (Zak) procedure for determination of cholesterol.


Gas-chromatographic determination of ethylene glycol in serum.


Use of a "three-isoenzyme diagram" in assessing activity of alkaline phosphatase isoenzymes.


Criteria for judging precision and accuracy in method development and evaluation.


Refinement and critical evaluation of a fluorometric method for measuring leucine aminopeptidase activity in serum or tissues.


Discrete sampling dilutor used in atomic absorption spectroscopy, with a modification permitting simultaneous analysis for total calcium and inorganic phosphorus.


Electrophoretic demonstration of three extra lactate dehydrogenase isoenzymes in the serum of a "normal" individual.


Letter: Interference with cholesterol determination.


Letter: Potential source of error in fluorometric analysis of dopamine.


Letter: Comments on the determination of diphenylhydantoin (cont.).


Letter: Expressing results of enzyme assays.


Letter: Boric acid interference with alumina extraction of urinary catecholamines.


Letter: Reagent for measurement of lecithin-sphingomyelin ratio.


Letter: Use of alkaline Sephadex G-25 for extraction and measurement of thyroxine.


Letter: Comments on a method for protein determination.


Letter: Stability of triglycerides in serum.


Letter: Specificity of analysis for glutethimide and its metabolites.


Editorial: Values and limitations of exercise electrocardiography.


The first heart sound in complete heart block. Phono-echocardiographic correlations.


The variable spectrum of echocardiographic manifestations of the mitral valve prolapse syndrome.


Echocardiographic evaluation of the Bjork-Shiley prosthetic valve.


Effects of maintenance digoxin therapy on systolic time intervals and serum digoxin concentrations.


Enhancement of electrical stability of acutely ischemic myocardium by edrophonium.


Renal tubular secretion of digoxin.

Renal tubular secretion of digoxin.


Effect of procaine amide, quinidine, and ajmaline in the Wolff-Parkinson-White syndrome.


Detection of hypokinesis by a quantitative analysis of left ventricular cineangiograms.


A comparison of regional blood flow and oxygen utilization during dynamic forearm exercise in normal subjects and patients with congestive heart failure.


Accelerated junctional escape. A clinical and electrocardiographic study.


Retrograde radioisotope myocardial perfusion patterns in dogs.


Tetralogy of Fallot with absent pulmonary valve. Natural history and hemodynamic considerations.


Criss-cross atrioventricular relationships producing paradoxical atrioventricular concordance or discordance. Their significance to nomenclature of congenital heart disease.


Letter: Pressure measurements with a safe and reliable catheter-tip micromanometer.


Complete His-Purkinje block produced by carotid sinus massage. Report of a case.


Letter: Conditions simulating the tetralogy of Fallot.


Letter: Lung scanning and angiography in pulmonary embolism.


Letter: Vasodilator therapy in acute MI.


Virus-associated tumours of the Harderian gland in laboratory-reared voles, Clethrionomys rutilus (Pallas).


Inverted papilloma of the bladder.

Inverted papilloma of the bladder.


Carcinoid heart disease.

Carcinoid heart disease.


Amprolium poisoning of preruminant lambs. An ultrastructural study of the cerebral malacia and the nature of the inflammatory response.


Cardiac infarction and yellow nail syndrome.


Pancreatic exocrine deficiency, chronic active hepatitis and familial autoallergic haemolytic anaemia.


Ulcerative colitis, colitic spondylitis and associated apical pulmonary fibrosis.


President's address. Otological balance.


What may we learn from cerebral malformations?


Asymmetric hindquarter syndrome (AHQS) in pigs.


Orofacial malformations.

Orofacial malformations.


Incidence, nature and etiology of malformations of the heart in man.


Anencephalus and dietary intakes.

Anencephalus and dietary intakes.


Reactions to routine immunization in childhood.


President's address. Muscle spasm in the etiology of chronic peptic ulcer.


Anencephalus and maternal tea drinking: evidence for a possible association.


Immunization: balancing the risks.

Immunization: balancing the risks.


Non-epileptic episodic disorders in young children.


Convulsive disorders in young children.

Convulsive disorders in young children.


Treatment of febrile convulsions.

Treatment of febrile convulsions.


Methods of clinical measurement and the approach to the problems of disability.


Radiotherapy of carcinoma of the oesophagus.


Techniques of gait analysis.

Techniques of gait analysis.


Editorial: Finance and the health service.


Wheelchair design--technological and physiological aspects.


Editorial: Simulated patients.

Editorial: Simulated patients.


Editorial: Another step to free movement.


Editorial: Onchocerciasis--river blindness.


Oligaemia, renal failure, and jaundice associated with acute pustular psoriasis. An episode of acute pustular psoriasis in a middle-aged man was associated with cholestatic jaundice and followed by acute tubular necrosis. It is suggested that renal failure was due to oligaemia after the loss of albumin into and from the skin. Fluid balance, central venous pressure, and arterial blood pressure should be monitored in patients with acute pustular psoriasis.


Thyrotoxicosis and giant-cell arteritis. In a retrospective survey we found that five (8.5%) out of 59 women with giant-cell arteritis had a history of thyrotoxicosis. This was significantly higher than in a control group of patients. Giant-cell arteritis and thyrotoxicosis occurred simultaneously in two cases. Knowledge of this association is of clinical use and is further evidence for an immunological basis for giant-cell arteritis.


Sensitivity to rifampicin: incidence, mechanism, and prevention. Five out of 200 patients taking rifampicin 900 mg twice weekly and three out of 91 patients taking rifampicin who attended an immunology clinic developed intolerance to the drug. Antibodies to rifampicin, which were found in most cases, decreased steadily after the end of treatment but were detectable for up to 16 months. The dose of rifampicin and the blood levels are predominating factors in the occurrence of reactions. Thus the dose should be reduced in patients in whom rifampicin blood levels rise abnormally. When it is important to continue rifampicin treatment despite intolerance antibody titres within 24 hours after administration of the drug must be measured to find when they are lowest, which determines the "unreactive period," and when a further dose may be safely given.


Speedboat propeller injuries.

Speedboat propeller injuries. Six patients are reported who were severely injured by high-speed boat propellers. With reasonable precautions such accidents need never occur, and people should be more aware of these and ensure that safety measures are enforced.


Letter: Five-day wards in 1974.

Letter: Five-day wards in 1974.


Health centre x-ray unit.

Health centre x-ray unit. An analysis of the types and numbers of x-ray films requested in the first year of a health centre x-ray unit showed that chest films represented the largest proportion of these. The unit is most valuable when it is inmediately available to the patient and general practitioner at the time of consultation, and thus it should be open for at least five sessions per week. The likely referral rate for the health centre x-ray unit is 84 patients per 1,000 at risk, and a unit functioning for five sessions a week can examine 60 patients during that time. This minimum of five sessions would be fully used by a population of 30,000 patients. The running costs were found to be about the same as those of a hospital x-ray unit.


Letter: Cannulation of internal jugular vein.


Letter: Coping with minor casualties.

Letter: Coping with minor casualties.


Letter: Lithium and weight gain.

Letter: Lithium and weight gain.


Letter: Attitudes to abortion.

Letter: Attitudes to abortion.


Letter: Vaccination of smallpox contacts.


Letter: Waiting for Brodrick.

Letter: Waiting for Brodrick.


Letter: Azathioprine in psoriasis.

Letter: Azathioprine in psoriasis.


Letter: Battering: unfortunate backlash.


Letter: Coxsackie B virus and diabetes.

Letter: Coxsackie B virus and diabetes.


Letter: Serotonin and the mesenteric circulation.


Letter: Serotonin metabolism in hepatic encephalopathy.


Letter: Death during dental anaesthesia.


Letter: Hangover and testosterone.

Letter: Hangover and testosterone.


Letter: Pseudotumours of the orbit.

Letter: Pseudotumours of the orbit.


Letter: Hypothermia, thrombosis, and acute pancreatitis.


Letter: Adverse reactions to intra-amniotic urea and prostaglandin.


Letter: Ideal consultation.

Letter: Ideal consultation.


Letter: Antioestrogens in treatment of breast cancer.


Letter: Place of the occupational therapist.


Seat belts and damages.

Seat belts and damages.


Editorial.

Editorial.


Poisoning due to ingestion of the seeds of kechubong (Datura fastuosa) for its ganja-like effect in Singapore.


Red cell survival and iron kinetics in kala-azar.


Treatment of Brugia malayi infection with levamisole.


Gastric phycomycosis: report of a case in Malaysia.


Pigment vs cholesterol cholelithiasis: comparison of stone and bile composition.


Free proteolytic enzymes in pancreatic juice of patients with acute pancreatitis.


The origin of human fecal alkaline phosphatase.


Gastric juice lactic acidosis. The incidence of gastric juice lactic acidosis in gastric cancer and benign gastric disease in communities of high and low gastric cancer incidence.


Intestinal immunoglobulins in pernicious anemia.


Cell-mediated immune response to hepatitis B antigen in patients with liver disease.


Circadian variation of prostaglandin E(PGE) production in human gastric juice.


Multiple leiomyomas of the esophagus.

Multiple leiomyomas of the esophagus.


Naturally occurring intestinal malabsorption in the dog.


Spermatic granuloma of the epididymis in rats treated with guanethidine.


Topography of the neonatal lung: scanning electron microscopic study of the onset of ventilation.


Lesions induced in rodents by extracts from cultures of Fusarium poae and F. sporotrichioides.


Intravenous regional lidocaine anesthesia in neurosurgical procedures.


The effects of brain stem compression on the heart.


Editorial: Information--where?

Editorial: Information--where?


Occipital artery--middle cerebral artery anastomosis for cerebral artery occlusive disease.


Extracranial congenital arterio-venous malformations.


Editorial: How much money--where?

Editorial: How much money--where?


Trauma induced alterations of concentration of monoamine metabolites in human cerebrospinal fluid.


Effects of prostaglandins A1, E1, E2 and F2alpha on the basilar artery of cats.


Letter: Irradiation induced tumors.

Letter: Irradiation induced tumors.


Cardio-respiratory alterations in head injury: patients' response to stimulation.


Alteration of cerebrospinal fluid production in the dog.


Proton radiography of a human brain tumor within the skull: a preliminary report.


Traumatic vertebral arterio-venous fistula.


The carpal tunnel syndrome.

The carpal tunnel syndrome.


Cystic meningioma of posterior fossa.

Cystic meningioma of posterior fossa.


Auditory cortical neurons in the cat sensitive to the direction of sound source movement.


Eye movement patterns of the encéphale isolé cat in the dark.


Permanence of visual perimetry deficits in monocularly and binocularly deprived cats.


Relationships of the neuronal activity of the superior colliculus to eye movements in the cat.


Some effects of chronic deafferentation on the ultrastructure of the nucleus gracilis of the cat.


Labelling of the gangliosidic fraction from brains of chickens exposed to different levels of stimulation after injection of (6-3H)glucosamine.


Neuronal activity in normal and cortically deprived interpositus neurons of the cat.


Stimulation of (3H)leucine incorporation into protein by estradiol-17beta or progesterone in brain tissues of ovariectomized guinea pigs.


The regulation of D-glycerate dehydrogenase from porcine spinal cord.


Calcium-dependent release of (14C)GABA from vinblastine and colchicine treated synaptosomes.


DNA polymerase activity in fractions from brain cell nuclei.


Conformation of nucleosides: circular dichroism study of solvent effect on the syn-anti conformational equilibrium of pyrimidine nucleosides.


Molecular orbital calculations on the conformation of nucleic acids and their constituents. XI. The backbone structure of (3'-5') and (2'-5')-linked diribose monophosphates with different sugar puckers.


Theoretical contribution to the mechanism of hydrolysis of the nucleosides.


A study of the RNA associated with chromosomal proteins in chromatin from Pisum sativum L. embryos.


Pituitary gland polyribosomal function in rats bearing pituitary hormone-secreting tumors.


Synthesis of lens protein in vitro. The lens cell-free system.


Gene frequencies of electrophoretically determined polymorphisms in Guernsey blood and milk.


Measurement of prolactin in milk by radioimmunoassay.


Development of disaccharidase and glycolytic enzyme activities of prenatal bovine fetuses.


Effect of adding sugars to a carbohydrate-free diet on intestinal disaccharidase activities in the young calf.


Effect of dietary sodium and potassium on udder edema in Holstein heifers.


Relationship of temperature and humidity to conception rate of Holstein cows in subtropical climate.


Transcellular creatinine disequilibrium and its significance in hemodialysis.


Protease substrate film test.

Protease substrate film test.


Adherence of blood components to dialyzer membranes: morphological studies.


Juxtaglomerular cell granulation and renal cortical renin activity in normal and adrenalectomized guinea pigs.


Familial renal tract abnormalities and cortical scarring.


Optimum topographical conditions for reverberating cortical spreading depression in rats.


After effects of spikes in cockroach giant axons.


Elevation of serum alkaline phosphatase in severe pyelonephritis and obstructive nephropathy.


Control of habituation of the withdrawal reflex by the gill ganglion in Aplysia.


The protein subunit of calf brain neurofilament.


Some chemical and electrophysiological effects of glutamate in cerebral cortex.


Memory evoked optomotor responses in crustaceans.


The visually evoked defense reflex of the crayfish: habituation, facilitation, and the influence of picrotoxin.


Insulin values of normal pancreatic and pancreatic adenomas tissue extracts in children.


Influence of thyroid state on cholesterol hydroxylation and absorption in the rat.