The effect of droperidol on the composition of blood gases in the acute phase of myocardial infarction.


Differentiation of ventricular pre-excitation by intracardiac electrocardiography.


Right atrium monophasic action potentials in patients with supraventricular tachycardia.


Incipient sclerotic vascular changes in lower limbs visualized with the aid of Fourier's harmonic analysis of the pulse wave.


Rehabilitation of patients with ischaemic heart disease. (Present status of the question, and actual problems).


Retrospective study of men who had undergone myocardial infarction at the age of 40 years or younger.


Analysis of peptidoglycan as a means in diagnostics of the genus Actinomyces.


Microbial decomposition of coumarin in soil.


Changes of microflora of wheat roots after foliar application of urea.


Recombinants between clock mutants of Chlamydomonas reinhardi. Mutants affecting the period length of the biological clock in Chlamydomonas reinhardi have been isolated and a start has been made on analyzing the genetics of this system. In four mutants, the long period characteristic seems to be controlled by single genes at separate loci. Crosses between single mutants, as well as crosses involving three or four mutant genes, yielded progeny with periods characteristic of the parents as well as recombinant types, including normal period (wild type) and extra-long periods (double, triple and quadruple mutants). It was found that the period lengthening effect is additive; that is, the period of double mutants is lengthened by the sum of the period lengthening of the single mutants.


Enzyme variability in natural populations of Daphnia magna. II. Genotypic frequencies in permanent populations. In permanent habitats populations of the cyclical parthenogen, Daphnia magna, reproduce by continued parthenogenesis and are subject to only sporadic sexual recruitment. The genetic effects of this breeding system have been investigated by analyzing allozyme frequencies in thirteen populations of D. magna.-Genotypic frequencies at polymorphic loci characteristically deviated markedly from Hardy-Weinberg proportions and gametic phase imbalance between loci was frequent. Genotypic frequencies were subject to violent, selectively determined oscillations over short periods of time. These observations suggest that permanent populations of D. magna ordinarily consist of a limited number of highly structured genotypes. The adaptational advantages offered by such structuring may have been a major selective factor favoring the evolution of cyclical parthenogenesis.


Enzyme variability in natural populations of Daphnia magna. 3. Genotypic frequencies in intermittent populations. In temporary habitats populations of the cyclical parthenogen, Daphnia magna, are re-established each year from sexual eggs and reproduce parthenogenetically for two or at most three generations. The genetic effects of this breeding system have been investigated by analyzing allozyme frequencies in nineteen intermittent populations.-Genotypic frequencies at polymorphic loci were ordinarily found to be in good agreement with Hardy-Weinberg proportions and disequilibria between loci were not observed. Although significant changes in gene frequencies were observed both during and between successive cycles, there was no evidence of the marked instability of genotype frequencies characteristic of permanent populations. The recombinational degradation of genotypes at the end of each annual cycle in temporary habitats effectively prevents the genotypic structuring which develops when continued parthenogenesis is possible.


Genetic variation in natural populations of five Drosophila species and the hypothesis of the selective neutrality of protein polymorphisms. We have studied genetic variation at 30-32 loci coding for enzymes in natural populations of five species of Drosophila. The average proportion of heterozygous loci per individual is 17.7 +/- 0.4%. The average proportion of polymorphic loci per population is 69.2 +/- 2.6% or 49.8 +/- 2.2%, depending on what criterion of polymorphism is used. The following generalizations are advanced: (1) The amount of genetic polymorphism varies considerably from locus to locus. (2) At a given locus, populations of the same species are very similar in the amount and pattern of genetic variation. (3) However, at some loci large differences sometimes occur between local populations of the same species. (4) The amount of variation at a given locus is approximately the same in all five species. (5) When different species are compared, the pattern of the variation is either essentially identical or totally different at a majority of loci. We have tested the hypothesis that protein polymorphisms are selectively neutral by examining four predictions derived from the hypothesis. Our results are at variance with every one of the predictions. We have measured the amount of genetic differentiation, D, between taxa of various degrees of evolutionary divergence. The average value of D is 0.033 for local populations, 0.228 for subspecies, 0.226 for semispecies, 0.538 for sibling species, and 1.214 for morphologically distinguishable species. Our results indicate that a substantial degree of genetic differentiation (22.8 allelic substitutions for every 100 loci) occurs between allopatric populations that have diverged to the point where they might become different species if they were to become sympatric. However, very little additional genetic change is required for the development of complete reproductive isolation. After the speciation process is completed, species continue to diverge genetically from each other.


Light and electron microscopic demonstration of cholinesterases of the cultured sympathetic ganglia of the chick embryo.


Note to the paper: protease substrate film test. (Histochemistry 38, 331-338 (1974). Warning of a pitfall.


The glyoxylic acid fluorescence histochemical method: a detailed account of the methodology for the visualization of central catecholamine neurons.


Inhibition of lordosis in female rats by subcutaneous implants of testosterone, androstenedione or dihydrotestosterone in infancy.


Flurophore formation from catecholamines and related compounds in the glyoxylic acid fluorescence histochemical method.


Avoidance learning at two levels of shock in rats receiving MSH1,2.


Extinction of an appetitive operant response after administration of MSH.


Estrogen-progesterone induction of mating in female rats.


Gonadotropin release as a function of mating and steroid feedback in the female rat.


Mounting and receptive behavior in the ovariectomized female rat:  influence of estradiol, dihydrotestosterone, and genital anesthetization.


Plasma corticosterone levels during sexual behavior in male rats.


Human karyotype polymorphism. II. The distribution of individuals according to the presence of brilliant bands in chromosomes 3,4, and 13 in a normal adult population.


Trisomy-8 syndrome.

Trisomy-8 syndrome.


ABO incompatibility and its interaction with haptoglobins and placental alkaline phosphatase.


Fetal face syndrome with mental retardation.


Neonatal tetanus in a military hospital.


Morbidity pattern in relation to parasitic diseases of the G.I. tract in an out patient clinic of a rural medical college.


Hypoplastic left heart syndrome. Report of two cases.


Hepatomegaly in infancy and childhood. An analysis of 30 cases.


An unusual presentation of diphtheria. Report of a case.


Benign retroperitoneal teratoma.

Benign retroperitoneal teratoma.


The use of hypnosis in crisis intervention.


Tethering of the conus medullaris within a lipomeningocoele.


Hypnosis and broad-spectrum behavior therapy for blepharospasm: a case study.


Hypnotic treatment of trichotillomania: two cases.


A case of multiple personality: diagnosis and therapy.


A note of possible limitations on the use of the Harvard Group Scale of Hypnotic Susceptibility, Form A.


Effects of visual sensory-restriction and recent experience with the imagined stimulus on a suggestibility measure.


The stability of hypnotic susceptibility: a longitudinal study.


When is an "instruction" an "instruction"?


Interaction of the alpha-ketoglutarate dehydrogenase complex with basic polypeptides.


Effect of isoproterenol on polyamine metabolism in mouse salivary glands.


Beta-galactosidases from jack bean meal and almond emulsin. Application for the enzymatic distinction of Galbeta1 leads to 4GlcNAc and Galbeta1 leads to 3GlcNAc linkages.


Comparison of adaptations to diet of enzymes involved in uric acid production from IMP in chickens and rats.


Purification of rabbit liver cathepsin B1.


Preparation of plasminogen activator from vascular trees of human cadavers. Its comparison with urokinase.


Sulfated glycoproteins capable of coagulating calcium carbonate isolated from pathological human bile.


Localization of troponin in thin filament and tropomyosin paracrystal.


Studies on soybean trypsin inhibitors. IX. Reconstitution of an active derivative from two inactive fragments and the contribution of tryptophan-93.


Chemical structure of glycolipid of guinea pig red blood cell membrane.


Preparation of an active fragment of potato proteinase inhibitor IIa and its properties.


Studies on the conversion of mevalonate into bile acids and bile alcohols in toad and the stereospecific hydroxylation at carbon atom 26 during bile alcohol biogenesis.


L-ascorbic acid sulfate esters with special reference to enzymatic hydrolysis.


Stabilization of pig kidney cathepsin A by sucrose and chloride ion, and inhibition of the enzyme activity by diisopropyl fluorophosphate and sulfhydryl reagents.


Circular dichroism studies on the interaction of the Lac repressor with Poly d(A-T) and nucleic acid components.


Relationships among the multiple components of beta-N-acetylhexosaminidase from equine kidney.


Properties of human erythrocyte acetylcholinesterase.


The response of non-traumatized bone to direct current.


Water binding in the articular cartilage of rabbits.


Electromechanical properties in human articular cartilage.


Low-velocity gunshot wounds involving the knee joint: surgical management.


Congenital contracture of the quadriceps muscle. Four case reports in identical twins.


False aneurysm of the femoral artery following total hip surgery.


Multiple chondromatous hamartomas.

Multiple chondromatous hamartomas.


Slipped capital femoral epiphyses and parathyroid adenoma.


Fracture and displacement of the odontoid process in a child.


Dorsal dislocation of the metatarsophalangeal joint of the great toe. A case report.


Rupture of the flexor profundus tendon of the ring finger secondary to ancient fracture of the hook of the hamate. Review of the literature and report of two cases.


Care, compassion, controls.

Care, compassion, controls.


Self-fulfilling prophecies: Reflections on the future of A.S.S.H.


Stable fixation of intertrochanteric fractures.


Autotransfusion in children's orthopaedics.


Re-evaluation of the position of the arm in arthrodesis of the shoulder in the adult.


Distal first metatarsal displacement osteotomy. Its place in the schema of bunion surgery.


Changing patterns of proximal femoral vascularity.


Tendon transfers to improve grasp after injuries of the cervical spinal cord.


Efficiency of assisted ambulation determined by oxygen consumption measurement.


The contribution of local factors to the elevated venous tone of congestive heart failure. Since the concept of an elevated venous tone in congestive heart failure (CHF) has been recently questioned, the venous volume of the elevated calf at a venous pressure of 30 mm Hg (VV[30]) was determined in 18 normal volunteers (N) and 10 CHF patients with a mercury-in-rubber strain gauge plethysmograph. CHF patients had a significantly lower VV[30] at rest and after intra-arterial phentolamine (2 mg) than normal subjects, suggesting that in these patients a state of peripheral venoconstriction existed (rest-N: 4.63+/-0.17, CHF: 1.7+/-0.23 ml/100 ml, P < 0.01; pre- and postphentolamine-N: 4.85+/-0.21 to 4.95+/-0.31, CHF: 2.26+/-0.29 to 2.68+/-0.38 ml/100 ml, P < 0.01). Of note is that alpha adrenergic blockade failed to increase VV[30] significantly in N, but did increase it in CHF (P < 0.05), suggesting that part of the decreased VV[30] in CHF in due to an augmented sympathoadrenal discharge. When sodium nitrite (30 mg) was given as a single intra-arterial injection before or after phentolamine or when given in four successive doses at 3-min intervals, the VV[30] of CHF patients was never increased to more than 3.62+/-0.42 ml/100 ml and was always less than N (P < 0.01). Importantly, VV[30] in CHF after these interventions was even significantly less than that of N before intervention (P < 0.05), suggesting that factors other than local active smooth muscle venoconstriction were operative in CHF to lower VV[30]. It is suggested that perhaps clinically undetectable edema and an elevated tissue pressure may account for these differences.


Plasma catecholamines and carbohydrate metabolism in patients with acute myocardial infarction. Blood glucose, glucose tolerance, serum insulin, free fatty acids in serum, plasma noradrenaline, and plasma adrenaline were measured in 10 patients with acute myocardial infarction (AMI) as well as in healthy subjects. Both noradrenaline and adrenaline in plasma were elevated in patients with AMI, the level being fairly constant in the individual patients and dependent on their degree of illness. In the fasting state, blood glucose, serum insulin, and free fatty acids were elevated in patients with AMI. Plasma noradrenaline showed a highly significant correlation with the fasting blood glucose concentration, but not with serum insulin or free fatty acids. The concentration of free fatty acids in serum could be predicted only if both plasma noradrenaline and the basal insulin concentration were known. Intravenous glucose tolerance was reduced in patients with AMI, especially in patients with high plasma noradrenaline and a low initial rise in insulin. There was a significant negative correlation between the initial rise in insulin expressed in percentage of the basal insulin concentration and the plasma noradrenaline level. The statistical effects of serum insulin and plasma noradrenaline on the glucose tolerance could not be separated from each other. The decline in free fatty acids after intravenous injection of glucose showed a negative correlation with plasma noradrenaline and a positive correlation with the initial rise in insulin. Plasma adrenaline did not correlate with any of the metabolic parameters mentioned above. The plasma noradrenaline concentration was elevated to such a degree in patients with AMI that the observed changes in metabolism might have been caused directly by the circulating noradrenaline. During the glucose tolerance tests, the effects of noradrenaline was probably carried out indirectly via a suppression of insulin secretion. It is conceivable that any effect of plasma noradrenaline on the basal insulin secretion was neutralized by the fasting hyperglycemia.


Circulating immune complexes in the serum in systemic lupus erythematosus and in carriers of hepatitis B antigen. Quantitation by binding to radiolabeled C1q. A sensitive and reproducible procedure for the detection of soluble immune complexes in sera from patients with various immunopathological disorders is reported. Radiolabeled C1q is reacted with sera containing immune complexes. Separation of free from complex bound [(125)I]C1q is achieved by selective precipitation with polyethylene glycol (PEG). The method is based on both the large molecular size and the C1q-binding property characterizing immune complexes. The minimal amount of aggregated immunoglobulins thus detected is about 10 mug and that of soluble human IgG-anti-IgG complexes is about 3 mug of complexed antibody. Some immune complexes formed in large antigen excess (Ag(2)Ab) can still be detected by this radiolabeled C1q binding assay. The specificity of the radiolabeled C1q binding test was documented by the inability of antigen-F(ab')(2) antibody complexes to lead to a precipitation of [(125)I]C1q in PEG. In a second step, this radiolabeled C1q binding assay was applied to an experimental model of immune complex disease and was shown to be efficient for the detection of in vivo formed immune complexes.Finally, the technique could be applied to the study of sera from patients with systemic lupus erythematosus (SLE) or to carriers of the hepatitis B antigen (HB-Ag). Significantly increased [(125)I]-C1q binding values were observed in 52 sera from SLE patients when compared to values obtained with healthy blood donors (P<0.001). Particularly high values were seen in active disease, a finding which was confirmed by follow-up studies performed with four SLE patients. No increased [(125)I]C1q binding was seen in 18 healthy carriers of the HB-Ag; whereas, sera from carriers with hepatitis appear to precipitate increased [(125)I]C1q percentages: 7/24 cases with acute transient and 4/7 cases with chronic persistent hepatitis were found to increasingly bind [(125)I]C1q. The results were also used for a correlative study of [(125)I]C1q binding to IgG levels in the sera but increased [(125)I]C1q binding could not be attributed to high serum IgG levels which are likely to account for gammaglobulin aggregates. These examples suggest the utility of the radiolabeled C1q binding assay for the evaluation of immune complex diseases in human pathology.


Inhibition of in vivo insulin secretion by prostaglandin E1. To determine the effect of prostaglandin E(1) (PGE(1)) infusion upon in vivo insulin secretion, serum insulin responses after an intravenous glucose pulse (2 g) were measured before and during an intravenous infusion of PGE(1) (10 mug/min) in 11 anesthetized dogs. Circulating insulin decreased significantly during PGE(1) infusion were significantly less than control responses. Three dogs received PGE(1) infusions into the thoracic aorta to preclude pulmonic and hepatic degradation of PGE(1) before its arrival at the pancreatic artery; inhibition of insulin secretion was again seen. Inhibition of insulin secretion could not be related to the degree of arterial hypotension induced by intravenous PGE(1), and despite alpha adrenergic blockade with intravenous phentolamine, PGE(1)-induced inhibition of glucose-stimulated insulin responses persisted. Significant increments in systemically circulating PGE levels during intravenous PGE(1) infusions were documented by radioimmunoassay. These studies demonstrate that systemic PGE(1) infusion inhibits insulin secretion and that this effect could not be shown to be dependent upon alpha adrenergic activity.


Studies on the in vivo effects of antibody. Interaction of IgM antibody and complement in the immune clearance and destruction of erythrocytes in man. Purified human IgM isoagglutinins were utilized to sensitize (51)Cr-labeled erythrocytes so as to produce a known number of complement-fixing sites. These cells were then reinfused into the erythrocyte donor. A minimum of 20 C1-fixing sites/erythrocyte were required for decreased survival. As the amount of antibody coating the erythrocytes was increased, a larger percentage was sequestered. With 80 C1-fixing sites, more than 75% of the injected erythrocytes were removed from the circulation within 10 min. In each case, the clearance pattern consisted of rapid hepatic sequestration followed by a gradual return of a portion of the erythrocytes into the circulation where they survived normally. Clearance was shown to be dependent upon activation of the classical complement pathway, since sensitized cells survived normally in hereditary angioedema patients with low levels of C4 and no detectable C2. Exposure of sensitized cells to fresh serum for 15 min led to the deposition of 550-800 C3 molecules/C1-fixing site. Such cells were immune adherence positive, were agglutinated by anti-C3b, formed rosettes with human alveolar macrophages, and were sequestered in vivo, presumably because of the interaction of cell-bound C3b with the C3b receptor on hepatic macrophages. After exposure to heated serum as a source of the C3b inactivator, the cells were immune adherence negative, were agglutinated only by anti-C3d, did not form rosettes with macrophages, and survived normally in vivo despite, being Coombs positive. Cleavage of cell-bound C3b to C3d may explain the release phase of the IgM clearance pattern. Whereas erythrocytes coated with IgM antibody and complement were previously thought to be sequestered in the liver because of extensive membrane damage, these experiments suggest that clearance is determined by the interaction of erythrocyte-bound complement fragments with specific receptors on hepatic macrophages.


Jejunal absorption and secretion of calcium in patients with chronic renal disease on hemodialysis. 10 patients with chronic renal disease on hemodialysis and 8 normals were studied by constant jejunal perfusion of calcium gluconate solutions, using polyethylene glycol as a nonabsorbable marker. Results in normals indicated that calcium absorption from 1 and 5 mM calcium solutions is mainly active. Absorption from 5, 15, and 20 mM solutions was a linear function of luminal calcium concentration, suggesting that the active transport carrier is saturated when luminal calcium concentration is greater than 5 mM and indicating that the increment in absorption at higher luminal concentrations is mainly the result of passive absorption. With 1 mM calcium, normals absorbed calcium against a concentration gradient, whereas the patients secreted calcium. Absorption in the patients was much less than normal with 5, 15, and 20 mM luminal calcium concentrations; however, the slope of this linear (passive) portion of the curve was normal. Unidirectional calcium fluxes were measured with calcium-47. Flux out of the lumen was depressed 2.5-fold in the patients, but flux into the lumen was normal. Xylose, urea, and tritiated water were absorbed normally, indicating no generalized abnormality of jejunal transport in these patients. Endogenous calcium secretion, estimated by the amount of calcium added to a calcium-free solution, was normal in the dialysis patients. These results indicate that active calcium absorption is markedly depressed in patients with chronic renal disease who are receiving hemodialysis therapy. On the other hand, passive calcium movement and endogenous calcium secretions are normal.


Secretion of parathyroid hormone in patients with medullary thyroid carcinoma. The secretion of parathyroid hormone (PTH) and calcitonin (CT) was studied in 30 patients with medullary thyroid carcinoma. Most patients with elevated levels of CT were normocalcemic and also had normal basal levels of PTH. Five of six patients with associated hyperparathyroidism were hypercalcemic and had elevated basal PTH levels. Hormone secretion was also studied during infusions with standard and low doses of calcium. PTH unexpectedly increased during 12 of 18 calcium infusions. Such a paradoxical increase in PTH was seen in those patients with the greatest increase in CT and the least increase in calcium during the calcium infusion. Accordingly, increases in PTH concentration during the calcium infusions could be correlated directly with increases in CT and correlated inversely with increases in calcium. These observations suggest that, in some patients with medullary thyroid carcinoma, a further increase in the abnormally elevated CT levels may stimulate PTH secretion. Therefore, at least in acute studies, there may be a functional, as well as a genetic, relationship between the secretion of these two hormones in patients with this thyroid tumor.


Hemoglobin affinity for oxygen in the anginal syndrome with normal coronary arteriograms. Oxyhemoglobin dissociation (OHD) curves were performed on whole blood (WB) from 20 patients with anginal pain, normal hemodynamics, and normal coronary arteries, as demonstrated by selective coronary cinearteriography. OHD curves in 19 of 20 patients, from zero to full saturation, were nearly identical to those in normal control subjects with values for P(50) (Po(2) at 50% saturation and pH 7.4) of 26.7+/-1.5 (mean+/-SD of the mean) torr (mm Hg) and red blood cell (RBC) levels of 2,3-diphosphoglyceric acid (2, 3-DPG) of 0.72+/-0.10 (mean+/-SD of the mean) M/M hemoglobin (Hb). Normal values for nonsmoking adults were: P(50), 26.6+/-1.4 (mean+/-SD of the mean) torr: and RBC 2,3-DPG, 0.81+/-0.09 (mean+/-SD of the mean) M/M Hb. Mean levels of carbon monoxide were normal at 0.14+/-0.01 (mean+/-SEM) ml/100 ml WB in 10 patients who were nonsmokers and 0.45+/-0.15 (mean+/-SEM) ml/100 ml WB in 10 smokers. In one patient, a heavy smoker with markedly elevated blood carbon monoxide levels, an abnormal leftward shift of the OHD curve was observed. This was corrected after discontinuation of smoking. In utilizing these methods, we could not detect consistent abnormalities of Hb affinity for oxygen at rest in the patients studied, which suggests that a defect in oxygen transport at rest is an unlikely explanation for the symptoms of chest pain in patients with the anginal syndrome and normal coronary arteriograms.


Balanced globin chain synthesis in hereditary persistence of fetal hemoglobin. In two black families with the hereditary persistence of fetal hemoglobin (HPFH) gene there are eight A-F heterozygotes and two double heterozygotes for sickle cell trait and HPFH. These patients are clinically asymptomatic and have homogeneous acid elution smears. Measurement of globin chain synthesis in peripheral blood demonstrates balanced production of a alpha and non-alpha (beta plus gamma) chains. In these patients, the balance is achieved by increased gamma globin production and increased activity of the remaining beta globin allele. In two patients, one A-F and the other S-F there is also balanced globin synthesis in the bone marrow. In a double heterozygote for HPFH and beta-thalassemia, anemia (Hb: 11.5 g/100 ml) is associated with a moderate degree of globin chain imbalance. There is a correlation between balanced globin chain synthesis and the absence of anemia in patients with HPFH.


Pure human big gastrin. Immunochemical properties, disappearance half time, and acid-stimulating action in dogs. Biological properties of pure natural human "big gastrin" (designated G-34 because it contains 34 amino acid residues) were compared with those of pure natural heptadecapeptide gastrins (G-17) from human and porcine sources. Radioimmunoassay inhibition curves indicated that G-17 was nearly 1.5 times more potent than G-34 with the antibody used in this study. This difference was confirmed by demonstration of increased immunoreactivity generated when G-34 was converted to G-17 by trypsinization. When infused intravenously into dogs with gastric fistulas and Heidenhain pouches in equimolar doses, G-34 produced slightly higher acid secretory responses than G-17. Responses to sulfated and nonsulfated forms were not significantly different, nor were responses to human and porcine G-17. During infusion of equimolar doses, steady-state serum gastrin concentrations were more than fivefold higher with G-34 than with G-17. The difference in steady-state blood concentrations could be accounted for by a corresponding difference in removal rates. The half times of the G-34 preparations averaged 15.8 min and the half times of the G-17 preparations averaged 3.2 min. The calculated spaces of distribution for G-17 and G-34 were similar, about 25% of body weight. When the increment in serum gastrin was plotted against acid secretory response it was found that nearly five times greater increments in molar concentrations of G-34 than of G-17 were required to produce the same rate of acid secretion. The potency of these two molecular forms of gastrin can be expressed in two different ways. Based on exogenous molar doses, the potencies of G-34 and G-17 were similar. However, based on molar increments in serum gastrin concentration, G-17 was approximately five times more potent than G-34. Hence, fractionation of these gastrin components may be important in estimation of the acid-stimulating action represented by total serum gastrin as measured by radio-immunoassay.


Studies of platelet 5-hydroxytryptamine (serotonin) in storage pool disease and albinism. Platelets in patients with storage pool disease are markedly deficient in a nonmetabolic (storage) pool of ADP that is important in platelet aggregation. They are also deficient in ATP, although to a lesser degree. In seven patients with this disorder, including one with albinism, platelet 5-hydroxytryptamine (5-HT) levels were reduced in proportion to the reduction in ATP (r = 0.94). Their platelets show diminished capacity to absorb [(14)C]5-HT, and the type of defect was similar to that produced in normal platelets by reserpine, a drug known to inhibit the uptake of 5-HT by the platelet dense granules. Storage pool-deficient platelets also converted more [(3)H]5-HT to [(3)H]5-hydroxyindoleacetic acid than did normal platelets, and the platelets in one of two patients studied contained increased amounts of 5-HT metabolites. The above findings, together with those reported previously, support the conclusion that the capacity of the dense granules (which may be either diminished or functionally abnormal) for storing 5-HT is decreased in storage pool disease; as a result, the 5-HT that enters the platelet may be more exposed to monoamine oxidases present on mitochondrial membranes. This diminished storage capacity (for 5-HT) may also explain why preincubating platelet-rich plasma with 5-HT for 45 min without stirring inhibits subsequent platelet aggregation by 5-HT to a greater degree in patients with storage pool disease than in normal subjects. The latter finding is also consistent with the theory that the aggregation of platelets by 5-HT is mediated by the same receptors on the plasma membrane that are involved in its uptake. The diminished release of platelet-bound [(14)C]5-HT by collagen that we found in these patients, as well as findings in previous studies, suggests that the release reaction may also be abnormal in storage pool disease.


Interventions for boys with conduct problems: multiple settings, treatments, and criteria.


Relationship between values, social class, and duration of psychotherapy.


Problem types of children referred to a school-based mental health program: identification and outcome.


Dichotic listening in schizophrenia.

Dichotic listening in schizophrenia.


Outcomes in group psychotherapy: using persuasion theory to increase treatment efficiency.


Conceptual ability, response interference, and arousal in withdrawn and active schizophrenics.


Personality research form: factor structure and response style involvement.


Effects of situational stress and sex roles on the attribution of psychological disorder.


Performance of paranoid schizophrenics on a dichotic listening task.


Multiple assessment of behavior modification with families: effects of contingency contracting and order of treated problems.


Effects of marathon group therapy on trait and state anxiety.


A combined treatment approach to the reduction of multiple fetish-related behaviors.


Determinants of social rejection for help seeking: locus of causal attribution, help source, and the "mental illness" label.


Subjective correlates of emotional responsivity and stimulation seeking in psychopaths, normals, and acting-out neurotics.


Modifying the academic performance of the chronic psychiatric inpatient.


Videotape versus verbal feedback in the modification of meal behavior of chronic mental patients.


Self-modification of depression.

Self-modification of depression.


Rapid smoking as a technique of behavior modification: caution in selection of subjects.


Pressure distribution on the body surface of swimming fish.


Oxygen-sensitive elements in the book gills of Limulus polyphemus.


Effects of pressure and temperature changes on the flagellar movement of crithidia oncopelti.


The passive permeability of insect malpighian tubules to organic solutes.


Electrophysiology of the giant nerve cell bodies of Limnaea stagnalis (L.) (Gastropoda: Pulmonata).


The electrophysiology of photoreceptors in the nudibranch mollusc, Tritonia diomedia.


The initiation and conduction of action potentials in the optic nerve of Tritonia.


Control of head movement in the locust, Schistocerca gregaria.


Net fluxes of water in the isolated gills of Anguilla dieffenbachii.


Neuronal modulation of photoreceptor activity in the bee moth Galleria mellonella.


The physiology of the tettigoniid ear. I. The implications of the anatomy of the ear to its function in sound reception.


The physiology of the tettigoniid ear. 3. The response characteristics of the intact ear and some biophysical considerations.


The physiology of the tettigoniid ear. II. The response characteristics of the ear to differential inputs: lesion and blocking experiments.


The physiology of the tettigoniid ear. IV. A new hypothesis for acoustic orientation behaviour.


Ventricular outflow dynamics in the lizard, Varanus niloticus: responses to hypoxia, hypercarbia and diving.


Directional sensitivity of microphonic potentials from the perch ear.


Gas exchanges and blood gas concentrations in the frog Rana ridibunda.


Colposcopy for the family physician.

Colposcopy for the family physician.


Health needs survey: Greene County, Indiana.


Instructions for witnesses.

Instructions for witnesses.


Treatment of pneumonias in infants and children.


Influence of inertia and gravity on fluid movement in small systems.


Quantitative transformation of osmotic energy into mechanical work by glycerol-extracted skeletal fibre bundles of rabbit psoas muscle and by gels of polyacrylic acid.


The efficiency of muscular contraction.

The efficiency of muscular contraction.


Regulation of myoplasmic calcium concentration in intact crayfish muscle fibers.


Was it due to quackery, witchcraft or complacency?


Reversible morphological changes in the contractile sphere of crayfish muscle fibers.


Practical aspects in the utilization of commonly used antiarrhythmic drugs.


Thoughts on medical malpractice.

Thoughts on medical malpractice.


Management of herpes zoster with H-influenza vaccine, a preliminary report.


See-saw nystagmus: an unusual sign of brain-stem infarction.


Histocompatibility types and measles antibodies in multiple sclerosis and optic neuritis.


The myopathology of the Kocher-Debré-Sémélaigne syndrome. Electromyography, light- and electron-microscopic study.


Posterior fossa medulloepithelioma. Report of a case.


Effects of alpha-methyltyrosine on d-amphetamine-induced release of endogenously synthesized and exogenously administered catecholamines from the cat brain in vivo.


The nerve impulse-blocking actions of tranquilizers and the binding of neuroleptics to synaptosome membranes.


The effect of morphine, meperidine, fentanyl and naloxone on the oxyhemoglobin dissociation curve.


The dopamine-releasing actions of neuroleptics and ethanol.


Skeletal muscle: reservoir for exogenous L-dopa.


Effects of prostaglandins B1 and B2 on vasoconstrictor responses of the canine hindpaw.


On the mechanism of scorpion toxin-induced release of norepinephrine from peripheral adrenergic neurons.


Effects of magnesium ion and oxytocin inhibitors on the uterotonic activity of oxytocin and prostaglandins E2 and F2ALPHA.


Turnover of histamine in rat brain and its decrease under barbiturate anesthesia.


Effects of calisthenics, jogging and swimming on middle-aged men.


Comparison of effects of two types of exercise programs on work capacity and electrocardiogram of patients with previous myocardial infarction.


Effects of aging upon U.S. masters championship swim performance.


Aerobic and anaerobic responses of male college freshmen during a season of basketball.


Maximal oxygen intake as a predictor of performance in running events.


Some motivational aspects of exercise.

Some motivational aspects of exercise.


The effects of physical tracing on the immunological response in mice.


A kinematic analysis of the golf swing by means of fast motion picture in connection with racial difference.


Effects of metered physical training on serum lipids of adult men.


Mechanism of poly(A) synthesis by vaccinia virus. Data are presented which indicate that vaccinia DNA does not contain poly(dT) sequences the size of poly(A) sequences (50 to 200 nucleotides in length) found in vaccinia RNA. A hybridization experiment and polyacrylamide gel electrophoresis and DEAE-Sephadex chromatography of pyrimidine tracts show that poly(dT) sequences can account for no more than 0.1% of vaccinia DNA. Ultraviolet irradiation (which causes thymine dimer formation) and phleomycin (which binds to thymidine) both inhibit RNA synthesis but not poly(A) synthesis by vaccinia cores. These data are consistent with a nontranscriptive mechanism for vaccinia poly(A) synthesis. Both trypsin and 50 C heat treatment inhibit RNA synthesis more than poly(A) synthesis by cores, suggesting that separate enzymes may be involved in these syntheses. When the rate of core RNA synthesis is reduced by lowering the UTP and GTP concentrations, the size of the poly(A) sequences increase. These and other data suggest that transcription is involved in the termination of poly(A) synthesis in cores. This might be due to the displacement of growing poly(A) chains by recently completed RNA 3' termini which have not yet acquired poly(A) sequences.


Point mutants in the D2a region of bacteriophage T4 fail to induce T4 endonuclease IV. We have studied the properties of presumptive point mutants in the D2a region of bacteriophage T4. Dominance tests showed that the D2a mutation was recessive to the wild-type allele. The mutations were shown to map in the D2a region by complementation against rII deletions. The D2a mutations were also located between gene 52 and rIIB by two- and three-factor crosses. The mutants are located at at least two distinct loci in the D2a region. The point mutants grow normally on all hosts tested and none of the mutants makes T4 endonuclease IV. We propose the name "denB" for the D2a locus.


DNA of a human hepatitis B virus candidate. Particles containing DNA polymerase (Dane particles) were purified from the plasma of chronic carriers of hepatitis B antigen. After a DNA polymerase reaction with purified Dane particle preparations treated with Nonidet P-40 detergent, Dane particle core structures containing radioactive DNA product were isolated by sedimentation in a sucrose density gradient. The radioactive DNA was extracted with sodium dodecyl sulfate and isolated by band sedimentation in a preformed CsCl gradient. Examination of the radioactive DNA band by electron microscopy revealed exclusively circular double-stranded DNA molecules approximately 0.78 mum in length. Identical circular molecules were observed when DNA was isolated by a similar procedure from particles that had not undergone a DNA polymerase reaction. The molecules were completely degraded by DNase 1. When Dane particle core structures were treated with DNase 1 before DNA extraction, only 0.78-mum circular DNA molecules were detected. Without DNase treatment of core structures, linear molecules with lengths between 0.5 and 12 mum, in addition to the 0.78-mum circles were found. These results suggest that the 0.78-mum circular molecules were in a protected position within Dane particle cores and the linear molecules were not within core structures. Length measurements on 225 circular molecules revealed a mean length of 0.78 +/- 0.09 mum which would correspond to a molecular weight of around 1.6 x 10(6). The circular molecules probably serve as primer-template for the DNA polymerase reaction carried out by Dane particle cores. Thermal denaturation and buoyant density measurements on the Dane particle DNA polymerase reaction product revealed a guanosine plus cytosine content of 48 to 49%.


Two modes of in vivo transcription for genes 43 and 45 of phage T4. Sensitivities of the expression of early genes of phage T4 to UV light were determined at various stages of intracellular development of T4 wild type, a DNA-negative mutant (T4 DO), and T4 tsG1, (a mutant that exhibits delayed expression of some T4 early genes). Whereas the sensitivities of some genes in the T4 wild type and T4 DO remain constant, genes 43 and 45 exhibit greatly reduced sensitivities several minutes after the onset of phage development. Since UV sensitivities are a measure of the distance of a gene from its promotor, these observations indicate a switch from distal, "immediate early" promotors to proximal, "delayed early" promotors for genes 43 and 45. In the tsG1 mutant this decrease in UV sensitivities of genes 43 and 45 does not occur at 42 C, suggesting that at high temperature this mutant does not utilize the delayed early promotors.


Can we predict which students will work overseas after graduation?


The allied health professions.

The allied health professions.


At the scene.

At the scene.


Towards Walden 3.

Towards Walden 3.


Aging. Pressing problems and emerging needs.


Perceptual and psychological changes in aging. An efficiency model.


Common psyciatric syndromes of the aged.


Access to the interior life of the aged.


Medical management of an aging population.


Amnion graft. The young helping the aged.


Retirement. Promise or threat?

Retirement. Promise or threat?


Human gerontology and geriatrics.

Human gerontology and geriatrics.


One alternative to institutionalization. In-home supportive services.


X-ray conference. White chunks in the urine.


Editorial: The doctor's role in the nursing home.


Editorial: Does psychiatry neglect the aged?


Valediction.

Valediction.


Fracture of the humerus and radial nerve palsy.


Saint Paul's school-based Streptococcal Detection Program.


Estimating bed needs by means of queuing theory.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-1974.


Vincristine therapy of idiopathic and secondary thrombocytopenias.


Letter: Aortography for aortic aneurysm.


Editorial: Recharting national health priorities: a new Canadian perspective.


Letter: Biologic data: stability of mean values.


Letter: Prehospital care for myocardial infarction.


Letter: Rarity of S.H. antigen (HBsAg) in bile.


Letter: Drug-induced acanthosis nigricans.


Letter: Dyskinesia after fenfluramine.

Letter: Dyskinesia after fenfluramine.


Letter: Adrenal hormones in dialysates.

Letter: Adrenal hormones in dialysates.


Letter: Improved pharmaceutical advertisements.


Letter: Reasons for recertification.

Letter: Reasons for recertification.


Letter: The humanist physician.

Letter: The humanist physician.


Medicine and Public Affairs. The sky is falling?


Editorial: A measure of sense.

Editorial: A measure of sense.


Vegetables?

Vegetables?


Nursing care study: Pulmonary tuberculosis complicated by constrictive pericarditis.


Treatment of head injuries.

Treatment of head injuries.


Management of prolonged coma.

Management of prolonged coma.


Advances in psychiatry. 6. Manic depression.


Nurses of the George Cross island.

Nurses of the George Cross island.


Advanced nursing education at the University of the West Indies.


Discrimination of stimulus duration and d-amphetamine in pigeons: a psychophysical analysis.


Acute and chronic effects of LSD and 3,4-dimethoxyphenylethylamine on shuttlebox escape-avoidance in rats.


Conditioned aversion in spatial paradigms following methamphetamine injection.


Alcohol and the acceptance of social influence: an experimental study.


The role of micro-organisms in flavour formation.


Practical aspects of synovial fluid aspiration. The approaches to major extremity joints and examination of the aspirate. Use of a few simple office laboratory procedures can provide accurate diagnosis of several forms of common diseases of joints. The average physician can discover unsuspected joint disease in this way, thereby avoiding expensive laboratory tests and delay in making the diagnosis. An adequate history and physical examination are needed in conjunction with analysis of fluid aspirated from the joint.


The use of propoxyphene napsylate in the treatment of heroin and methadone addiction. The use of methadone in the treatment of heroin addiction continues to be controversial. Propoxyphene napsylate (Darvon N(R)) is a possible alternative and a pilot study was conducted to test its acceptability, safety and clinical efficacy in treating long term, "multi-relapse" heroin addicts. Findings indicate that propoxyphene napsylate suppresses many of the symptoms associated with opioid withdrawal phenomena. It should be viewed as a very promising therapeutic tool to be used in conjunction with psychological counseling and socio-vocational rehabilitation in detoxification and maintenance therapy for heroin or methadone addiction.


U.C.S.D. Dept. of Psychiatry Grand Rounds. Anorexia Nervosa.


Medical staff conference: Wegener's granulomatosis.


Editorial: Critical masses in the distribution of health care services.


Editorial: Gallium-67: broad spectrum diagnostic?


Editorial: New hope for an old ill--anorexia nervosa.


Tick-bite in Oregon: Paralysis in California.


Localization of a parathyroid adenoma by thermography.


Tricuspid atresia and aortic origin of right pulmonary artery in a nine-year-old girl.


The guideposts in the RMP odyssey.

The guideposts in the RMP odyssey.


The epidemiology of influenza in California, 1968-1973. Influenza is one of the most common acute febrile respiratory diseases in adults. Epidemics caused by influenza viruses occur every few years. When such epidemics are in progress, the medical community, the general public and the news media seek information regarding the presence, spread and severity of influenza. The methods and findings of the Influenza Surveillance System in California for the years 1968 through 1973 should be of interest generally. This period spans the total California experience with the type A Hong Kong variant (A/Hong Kong/1/68 [H(3)N(2)]), and the first appearance of the English strain of type A influenza virus (A/England/42/72 [H(3)N(2)]). The surveillance of influenza during this period showed that there were major epidemics in Calfornia only during the state's first experience with the type A Hong Kong variant in 1968-69, and with the English strain in 1972-73. Problems and limitations in influenza surveillance do exist. Nonetheless, the major surveillance indices used (school absenteeism, laboratory data and deaths from pneumonia and influenza) are reliable and sensitive indicators of general trends of influenza virus activity. These indices are most useful in comparing the relative severity of influenza epidemics. However, since these indices usually lag several weeks behind the occurrence of disease, this lag must be considered in making estimates of current incidence trends based on these indices.


Gallium-67 scans in the diagnosis of pyelonephritis. Gallium-67 ((67)Ga) citrate was administered intravenously (50 microcuries per kg of body weight) to patients in whom acute and chronic urinary tract infections were suspected. Scanning was done, using both the Anger-type scintillation camera and the rectilinear scanner, 24 to 78 hours after injection of the isotope. The preliminary results imply that (67)Ga renal uptake is present in patients with pyelonephritis whether overt or silent, as well as in patients with uretero-sigmoidostomies. However, (67)Ga renal uptake is not present in patients with radiographic evidence of chronic pyelonephritis without active infection and in patients without renal disease.


Aortic lymph node metastases in early ovarian cancer.


The effect of epidural analgesia upon fetal and neonatal status.


Comparison of the patterns of androstenedione, progesterone, and estradiol during the human menstrual cycle. The pattern of androstenedione (A), serum estradiol (E2), and progesterone was measured during the menstrual cycle.  No clear-cut pattern was observed for A such as was observed for E2 and progesterone.  The mean levels of A tended to increase from Day 1 of menses to midcycle in all women, following the luteinizing hormone (LH) peak, but with marked fluctuation.  A significant decline (p.05) in mean A levels from the LH peak to the day prior to menses was noted in all subjects.  The ovaries secreted A throughout the menstrual cycle, with the lowest rate just prior to menses.  The marked daily variation in A was most likely caused by the adrenal gland.  Whether or not A has a luteal origin has not been resolved.


Intrauterine contraception in multiparas with the Dalkon Shield.


Electrocardiographic changes during intrauterine contraceptive device insertion.


Cervicovaginal fistula: an apparent increased incidence with prostaglandin F2alpha. A rare but difficult to treat complication of midtrimester abortion is cervicovaginal fistula.  It has been reported as a consequence of criminal, spontaneous, and induced abortions with either laminaria, Hegar dilatation, puncture of the ovum, or by injection of soap.  This condition was recently reported as a consequence of intraamniotic hypertonic saline or prostaglandin (PG) instillation.  At the Women's Hospital in Los Angeles, 5291 midtrimester abortions with intraamniotic instillation of hypertonic saline had been performed since the advent of elective abortion.  There were 4 cases of central cervical rupture (cervicovaginal fistula) for a net incidence of 1:1000.  3 out of 373 intraamniotic PGF2alpha-treated patients developed cervical fistula for an incidence 10 times higher than saline abortion.  Other studies confirm this finding.  If all such studies are combined, the net incidence is 9 in 678 cases or 1.3%.  High risk patients include those who are pregnant for the 1st time, are less than 21 years old, and are treated with hypertonic saline augmented by oxytocin.  The fistula may occur with intraamniotic PGF2alpha alone, but the incidence is greater in patients receiving PGs and oxytocin together.  A recurring feature is a moderate to severe cramping pain without cervical response even before oxytocin is started.  The use of mechanical dilatation of the cervix with the introduction of either laminaria tents or Foley catheters is suggested for primigravid patients receiving hypertonic saline and intravenous oxytocin augmentation.  If cervical spasm is the mechanism of action of PGF2alpha, initial insertion of laminaria should be considered with all primigravid patients.  Further study of a larger series should be done to elucidate the role of PGs in the development of cervicovaginal fistula.  7 case reports are presented.


Carbohydrate metabolism in previable fetal death.


Management of gestational diabetes.

Management of gestational diabetes.


Classic pages in obstetrics and gynecology. An inquiry into the nature and cause of that swelling, in one or both of the lower extremities, which sometimes happens to lying-in-women together with an examination into the propriety or drawing the breasts, of those who do, and also of those who do not give suck.


Birth weight in Fiji and Western Samoa: a Pacific prescription for pregnancy?


Podophyllin poisoning associated with the treatment of condyloma acuminatum: a case report.


Carcinoma in situ of the cervix after amethopterin therapy.


Absence of prostaglandin E1 metabolism in hydatidiform mole.


Letter: Chemical designations for the dinitrobenzenes.


Letter: Aspiration of uterine lining for evaluation of endometrium and uterine contents.


Letter: The immediate postnatal weight change of small-for-date newborn infants.


Letter: Incomplete testicular feminization.


Self-perception of independence among urban elderly.


Abnormal postural reflexes.

Abnormal postural reflexes.


Activity patterns and leisure concepts among the elderly.


Letter: Legislation committee activities.


Retinal oxalosis in two diabetic patients.


Ring maculopathies mimicking chloroquine retinopathy.


Ocular manifestations of the ectrodactyly, ectodermal dysplasia, cleft lip-palate syndrome.


Benign pigmented tumors, arising in acquired conjunctival melanosis.


The basal cell nevus syndrome.

The basal cell nevus syndrome.


Recovery of vision in association with a melanocytoma of the optic disk.


Posttraumatic migration of retinal pigment epithelial melanin.


Effects of ophthalmic ointments on intraocular penetration of topical fluorescein in rabbits and man.


Ultrasonography and vitrectomy.

Ultrasonography and vitrectomy.


Infrared pupil camera. A new method for mass screening and clinical use.


Extraocular muscle imbalance after surgical treatment for retinal detachment.


Internal limiting membrane detachment in branch retinal vein obstruction.


Hirsutism after chronic administration of acetazolamide.


An eyelid retractor for ocular surgery.

An eyelid retractor for ocular surgery.


Bilateral retrobulbar neuritis secondary to mumps.


Hand support rail and surgical chair for microsurgery.


Corneal irrigation using a syringe and a butterfly needle.


A rapid, accurate technique for retinoscopy of the aphakic infant or child in the operating room.


Spectacles for microsurgery.

Spectacles for microsurgery.


Equipment case for ocular examination equipment.


Editorial: National Eye Institute 1974.

Editorial: National Eye Institute 1974.


Letter: Charts for neuro-ophthalmology courses.


Sterile drape fro Zeiss microscope.

Sterile drape fro Zeiss microscope.


Effect of contact lens motion on the oxygen tension distribution under the lens.


The effect of saline solutions of various compositions on hydrogel lens dimensions.


A review of anterior segment photography.


Soft (hydrophilic) contact lenses in U.S. Army aviation: an investigative study of the Bausch and Lomb Soflens.


Analysis of optometric findings using a punch card retrieval system.


Vision anomalies of school children.

Vision anomalies of school children.


Examining and fitting identical twins with contact lenses: a case report.


Visual therapy for small angle esotropia.


Public awareness of health care facilities and the role of optometry.


Letter: Comments on "optometry and ophthalmology" by Hirsch.


Letter: Spectacle blur with flexible lenses.


Aggression in childhood. Developmental perspectives.


Instrumental conditioning of autonomically mediated responses in human beings.


A survey of behavior modification training opportunities in APA-approved internship facilities.


Population ecology of Sulfolobus acidocaldarius. I. Temperature strains.


Sexuality in Mucorales. The effect of plus-minus ratio on hormone production by mated cultures.


Studies on the growth of Thiobacillus ferrooxidans. IV. Influence of monovalent metal cations on ferrous iron oxidation and uranium toxicity in growing cultures.


Molar growth yield of Nitrobacter winogradskyi during exponential growth.


Coats disease.

Coats disease.


Clinical evaluation of an infrared refracting instrument.


Low-dose epinephrine.

Low-dose epinephrine.


Ocular manifestations of xeroderma pigmentosum in a black family.


Balloon cell melanoma of the choroid.

Balloon cell melanoma of the choroid.


A modified lacrimal probe.

A modified lacrimal probe.


Trabecular surgery.

Trabecular surgery.


Deglutition--trochlear synkinesis.

Deglutition--trochlear synkinesis.


Acute posterior multifocal placoid pigment epitheliopathy.


Insidious atrophy of retinal nerve fibers in multiple sclerosis. Funduscopic identification in patients with and without visual complaints.


Prostaglandin f-2-alpha for the induction of labor in pregnancies complicated by intra-uterine death, anencephaly and chromosomal anomaly.


Induction of therapeutic abortion using either extra-amniotic prostaglandin F-2-alpha or hypertonic saline followed by oxytocin. 160 women with uteri at 10-20 weeks gestation were treated with either PG(prostaglandin)F2alpha or saline solution followed by oxytocin to effect an abortion.  80 women were in each treatment group.  The distribution of the patients according to age, parity, and gestation duration is tabulated.  PGF2alpha was administered extraovularly in a concentration of .1 mg/ml with .7 mg being injected in the operating theater and nurses administering the rest based on response to previous injections.  Administration continued for up to 30 hours.  Saline was given in a volume in ml dependent on the duration of pregnancy multiplied by a factor of 10.  Subcutaneous injections of oxytocin were given on subsequent days to speed the abortion.  85% of the PG patients successfully aborted without surgical dilatation of the cervix.  The average dosage of PG required was 7.5 mg in 11 instillations.  Side effects and complications in the PG group were minimal.  1 instillation of saline followed by 2 days of oxytocin were required to effect a 79% abortion rate in the saline group.  Although the number of patients requiring surgical dilatation was the same for both groups, the procedure was much less time-consuming for the PG group.  The complication rate was 26% for the saline group as compared to 14% for the PG group.  The PG group required a shorter hospital stay.


Icreased excretion of 5alpha, 7alpha-dihydroxy-11-keto-tetranor-prostanoic acid on anaphylaxis in the guinea-pig.


Contributions of paternal care to the growth and development of the young in Peromyscus californicus.


Environmental and hormonal influences on urine marking behavior in the adult male dog.


Food hoarding in muroid rodents.

Food hoarding in muroid rodents.


An analysis of the facilitation of avoidance acquisition produced by d-amphetamine and scopolamine.


Facilitation of avoidance acquisition by lesion of the median raphe nucleus: evidence for serotonin as a mediator of shock-induced suppression.


Modification of escape from noxious stimuli after bulbar reticular formation lesions.


Passive-avoidance performance in mice: evidence for single-locus inheritance.


Taste-aversion conditioning in rats with septal lesions.


Paternal behavior in the California mouse, Peromyscus californicus.


Individual differences in the biological odors of the Mongolian gerbil (Meriones unguiculatus).


Modifications in the copulatory performance of male rats produced by repeated peripheral shock.


Refractory period and adaptation in prolonged brain reward.


Nervous system function: behavioral influences of gene effects on peripheral nerve conduction velocity in mice.


Enhancement of D-glucuronolactone and acetaldehyde dehydrogenase activities in the rat liver by inducers of drug metabolism.


Imipramine-mediated effects on levodopa metabolism in man.


Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine).


Effect of treatment with phenobarbital and spironolactone on 144Ce levels in blood, liver, urine and faeces at various time periods.


Effect of cytosine arabinoside triphosphate on deoxyribonucleic acid synthesis in permealysed cells from Ehrlich ascites tumour. Studies of phosphorylated drub metabolites on quasi-normal deoxyribonucleic acid replication.


Mode of action of the calcium ionophores X-537A and A23187 on cardiac contractility.


Effect of organophosphate pesticides on lecithin-cholesterol acyltransferase in human plasma.


Inhibition of mammalian brain acetylcholinesterase by ketamine.


Isolation and amino-terminal sequence analysis of two dissimilar pancreatic proelastases from the African lungfish, Protopterus aethiopicus.


Troponin, tropomyosin, and actin interactions in the Ca2+ regulation of muscle contraction.


Photochemical labeling of the surface proteins of human erythrocytes.


Chemical synthesis and properties of analogs of adenosylcobalamin.


Poly(2-methyl-N6-methyladenylic acid): synthesis, properties, and interaction with poly(uridylic acid).


Influence of 2'-O-alkylation on the structure of single-stranded polynucleotides and the stability of 2'-O-alkylated polynucleotide complexes.


Structural studies on normal horse immunoglobulin light chains. Detection of k-type N-terminal sequences.


Photoconvertible protochlorophyll(ide)635-650 in vivo: a single species or two species in dynamic equilibrium?


Further data on the identity of a pigment absorbing around 640 nm in Ulva lactuca.


A convenient electrochemical preparation of reduced methyl viologen and a kinetic study of the reaction with oxygen using an anaerobic stopped-flow apparatus.


Effects of carbonyl cyanide m-chlorophenylhydrazone and hydroxylamine on the photosystem II electron exchange mechanism in 3-(3,4-dichlorophenyl)-1,1-dimethylurea treated algae and chloroplasts.


Temperature dependence of delayed light emission in spinach chloroplasts.


Studies on the energy coupling sites of photophosphorylation. IV. The relation of proton fluxes to the electron transport and ATP formation associated with photosystem II.


Studies on the control of pyruvate oxidation in isolated fetal rat liver cells.


Relations between fluorescence and thylakoid structure in Porphyridium cruentum.


Sterol metabolism. 28. Biosynthesis and accumulation of cholest-5-ene-3beta, 24-diol (cerebrosterol) in developing rat brain.


Solubilization of a long chain fatty acyl-CoA synthetase from chicken adipose tissue microsomes.


Lipolytic activity of adipose tissue. 3. The triacylglycerol lipase activity of human adipose tissue: a re-evaluation.


A competitive protein binding assay specific for prostaglandin E.


Intestinal absorption of prostaglandin F2alpha, 15(S)-15-methyl prostaglandin F2alpha and their methyl esters in the dog.


Identification of methoxyester artifacts produced by methanolic-HCI solvolysis of the cyclopropane fatty acids of the genus Yersinia.


The fatty acids present in the lipopolysaccharide of Vibrio cholerae 569B (Inaba).


Lipogenesis from lactate in rat adipose tissue.


3Beta-hydroxysteroid dehydrogenase in rat testis tissue. Inter- and subcellular localization and inhibition by cyanoketone and nagarse.


Dynamics of erythrocyte lipids in intact cells, in ghost membranes and in liposomes.


The substrate profiles of the acidic and slightly basic horseradish peroxidases.


Aldolase C in rat fetal liver.

Aldolase C in rat fetal liver.


Studies concerning the biochemical genetics of activity and feedback inhibition mutants of Schizosaccharomyces pombe 3-deoxy-D-arabino-neptulosomate-7-phosphate synthase.


Biostereochemistry of histidine metabolism. II. The steric course of ammonia elimation from L-histidine.


Studies on porphobilinogen deaminase and uroporphyrinogen 3 cosynthase from human erythrocytes.


Partial purification and initial studies of the tomato L-alanine:2-oxoglutarate aminotransferase.


Production of microbial neuraminidases induced by colominic acid.


An affinity adsorbent for N-acetyl-beta-D-hexosamindiase A.


Isolation and characterization of omega-gliadin fractions.


Activation and inhibition of AMP deaminase by GTP and ATP.


Erythrocruorin with anomalous quaternary structure from the polychaete Oenone fulgida.


Electrophoresis of avian erythroid histones.


The crystal and molecular structure of a complex formed by guanidine hydrochloride and glycylglycine, (C(NH2)3)CI C4N2O3H8.


Incorporation of radioactive leucine and fucose in brain plasma membrane proteins fractionated by polyacrylamide gel electrophoresis.


Extraction and characterizaiton of a "native" vitamin A-sensitive glycoprotein from rat intestine.


Helix-coil transition in nucleoprotein: renaturation of polylysine-DNA and polylysine-nucleohistone complexes.


The effect of thymine dimers on DNA:DNA hybridization.


The elastic properties of elastin.

The elastic properties of elastin.


Statistical thermodynamics of triple-helix unzippering for the collagen model (Gly-Pro-Pro)n and implications for natural collagen.


Enthalpies of helic-coil transitions in polypeptides.


NMR studies of poly-gamma-benzyl-l-glutamate in trifuloroacetic-deuterochloroform solutions: temperature dependence.


Effects of water on the mechanical properties of gelatin films.


13C nmr study of the helix-coil transition of poly-N5-(3-hydroxypropyl)-L-glutamine.


The strand-separation transition of T2 bacteriophage DNA.


The strand-separation transition of T7 DNA.


A circular dichroism study of the primary structures of three crab satellite DNA's rich in A:T base pairs.


Intrinsic viscosity of poly(alpha-L-glutamic acid) in N-methylacetamide.


Counterion activity of ionizable polypeptides.


A brain pathway for thalamically evoked calls in birds.


The problem of vigilance in animal life.


Recovery in visual cortical neurons following total visual deafferentation.


Differential phylogenetic development of the acoustic nuclei among chiroptera.


The effect of deafferentation on the postnatal development of Clarke's nucleus in the kitten--a Golgi study.


Receptive fields of cat retinal ganglion cells having slowly conducting axons.


Glossopharyngeal influences on hypoglossal motoneurones in the cat.


The efferent connections of the head of the caudate nucleus in the cat: an experimental morphological study with special reference to a projection to the raphe nuclei.


Free amino acids and related compounds in the dorsal root ganglia and spinal cord of the rat as determined by the micro dansylation procedure.


Piperidine concentration changes in the brain and blood of dormant mice.


Chemical or electrolytic lesion of the substantia nigra: early effects on neostriatal dopamine metabolism.


Turnover of proteins in myelin and myelin-like material of mouse brain.


Ultrastructural localization of surface concanavalin A binding sites in a unicellular organism, Amoeba proteus.


Analysis of the sensory projection from the tarsal sensilla of the blow-fly (Phormia terraenovae Rob.-Desv., Diptera). Experimental degeneration of primary fibers.


The carotenoid pigments of Schizonobia sycophanta Womersley (Acari: Tetranychidae).


A comparative study of hagfish and rat liver histones.


Nuclear DNA amounts in crustacea.

Nuclear DNA amounts in crustacea.


Carotenoids in Euglena rubida mainx.

Carotenoids in Euglena rubida mainx.


Correlation between muscular lactate dehydrogenase isoenzyme patterns and flight habits of bats.


Proline metabolism in Trypanosoma scelopori epimastigotes.


Identification of serum proteins following different stages of sodium sulfate precipitation of chicken serum.


Effect of exercise on gastric emptying and gastric secretion.


The liver in amyloidosis.

The liver in amyloidosis.


Influence of auxins on growth ans cytohistology of fenugreek (Trigonella foenum-graecum L.) calli.


Effects of intragastric and intraduodenal ethanol on canine exocrine pancreatic secretion.


Release of proteases from leukocytes by dog bile in vitro.


Intestinal lymphangiectasia. Report of a case with asymmetrical juandice.


Leukocytic proteases in gallbladder pathology. Experimental acute cholecystitis in dogs.


Extracorporeal perfusion of excised canine small bowel segments. Studies of the intestinal absorption, secretion and metabolism.


Two more benzodiazepines: clorazepate and flurazepam.


Exocrine pancreatic secretion and output of bile in humans under conditions of hypoglycemia and administration of atropine.


Total synthesis of (plus or minus) hyalodendrin.


Volatile ketones in the hairpencil secretion of danaid butterflies (Amauris and Danaus).


Lobster molting hormones: isolation and biosynthesis of ecdysterone.


Adaptive metabolic variation of chromosome forms in mole rats, Spalax.


Resolution of temperature-dependent conformers of histidine ammonia-lyase on disc gel electrophoresis: correlation with Arrhenius discontinuities.


On the nature of unretarded protein in a chain separation method of hemoglobin.


Ribonuclease activity of rat thymus chromatin proteins.


The effect of isoniazid on human chromosomes studied by a new method.


Increased phosphorylation of liver histone F1 following the administration of 3,5,3'-triiodo-L-thyronine (T3).


The chromosomes of Italian sturgeons.

The chromosomes of Italian sturgeons.


Oceanian type black rats (Rattus rattus) with a subtelocentric M2 chromosome and C-type transferrin obtained from North America.


Effects of abscisic acid on photosynthesis of protoplasts from Petunia hybrida.


Mitotic activity in lemon fruit explants (Citrus limon L.) incubated on a calcium-potassium-sucrose medium.


Effects of high gravity on amoebae (Pelomyxa carolinensis). I. Division rates.


The probable significance of the differential occurrence of protein in various castes of the termite Odontotermes assmuthi (Isoptera: Termitidae).


The membrane expansion theory of anesthesia: direct evidence using ethanol and a high-precision density meter.


Time dependence of a neurochemical correlate of a learning task: a non-disruptive approach to memory consolidation.


Phosphorus metabolism in grape buds during floral initiation.


Utilization of a cellular calcium pool for contraction of the human myometrium.


Temperature responses of exercizing dogs to infusion of electrolytes.


The ability of cod (Gadus morhua) to orient towards a sound source.


Effect of starvation on blood glucose and nonprotein nitrogen levels of the fish Clarias batrachus.


Tranexamic acid and fibrinolytic activity of the vessel wall.


Ciliary action and normal movement of odorant wavefronts in garfish nasal capsule of Lepisosteus osseus.


Physostigmine attenuation of delta 9-tetrahydrocannabinol induced hyperthermia in rats.


Production of duodenal ulcers in the rat by administration of digitoxin.


Anhydrotic effect of benzodiazepines in mice.


Development of the adrenergic innervation in the ureter and vas deferens in rabbits.


Catecholamines in human fetal heart.

Catecholamines in human fetal heart.


Cytotoxic effect of di(2-ethylhexyl) phthalate on cultured chick embryonic cells.


Secondary teratogenic factors.

Secondary teratogenic factors.


Alterations in the structure of the Octopus vulgaris chromatophore by cytochalasin B.


Cytoplasmic changes in primary neural induction.


Demonstration of mast cells in the albino rat brain.


Equivalence of continuous infusion and single injection of 3H-thymidine for analysis of intravascular kinetics of neutrophilic granulocytes in the rat.


Effects of prostaglandin E2 on the uptake of 3H-thymidine in pregnant mice.


The response of the adrenal gland to hypoglycaemia in the conscious calf.


Crustecdysone is without estrogenic or antiestrogenic activity in the rat.


Comparison of some biological activities of arginine vasotocin and synthetic analogs.


Action of L-dopa on the gonads of male rats.


Hyperglucagonemia, hypocalcemia and diminished gastric blood flow-evidence for an etiological role in stress ulcer rat.


On the antagonism of ergot alkaloids and dopamine by phenothiazines.


The changes in basal corticosterone secretion in rats blinded at birth.


Crossed immunoelectrophoresis: an alternative method for identification, quantification and characterization of membrane proteins.


Ultracryotomy shows the crystae of mitochondria.


The oxidation of some carcinogenic arylhydroxylamines to nitroso derivatives with manganese dioxide.


Editorial: The perils of instant publicity.


A simple routine-method to preserve and determine blood serotonin.


Multiple neoplasms occurring in a single individual.


Keratoconus appearing after contact lens wear.


Dermoid cysts of the face--recommendation for early excision.


Oxyphil adenoma (oncocytoma) of parotid with hemorrhage: presentation as an enlarging neck mass.


Idiopathic sudden deafness.

Idiopathic sudden deafness.


Internal anal sphincter derangement with anal fissures.


Intraluminal esophageal manometry: an analysis of variables affecting recording fidelity of peristaltic pressures.


Sodium transport across isolated human jejunum.


Studies on the necessity of a bolus for the progression of secondary peristalsis in the canine esophagus.


Plasma protein shedding by the canine oxyntic glandular mucosa induced by topical application of snake venoms and ethanol.


Hypothermia in restraint-induced gastric ulcers in parabiotic rats.


Direct and indirect effects of nicotine on rabbit pancreatic secretion.


Hemolytic anemia of Wilson's disease.

Hemolytic anemia of Wilson's disease.


Birefringence of hepatic pigment deposits in erythropoietic protoporphyria. Specificity of polarization microscopy in the identification of hepatic protoporphyrin deposits.


Effect of phenobarbital on liver functions in patients with Dubin-Johnson syndrome.


An algorithm for monitoring and managing drug hepatotoxicity.


Route of flow and micropathology resulting from retrograde intrabiliary injection of India ink and ferritin in experimental animals. A combined light- and electron-microscopic study.


Blind loop syndrome associated with growth retardation.


Intrahepatic hematoma after liver biopsy.


Duplication of the ileum with heterotopic gastric mucosa pseudomyxoma peritonei and nonrotation of the midgut.


Editorial: Digestive diseases as a national problem: public policy and funding for biomedical research.


Letter: Vitamin B12 malabsorption in chronic pancreatitis.


Letter: Comparative anatomy of the esophagus.


Ribosomal DNA sites in a metacentric chromosome fragment.


A family with congenital pulmonary valve stenosis.


Comparative studies on the distribution of aberrations on human chromosomes treated with busulphan in vivo and in vitro.


The naso-temporal division of the cat's retina re-examined in terms of Y-, X- and W-cells.


Synaptic organization of the nucleus gracilis of the cat. Experimental identification of dorsal root fibers and cortical afferents.


Good continuation revisited.

Good continuation revisited.


Ontogeny of monoamine neurons in the locus coeruleus, Raphe nuclei and substantia nigra of the rat. I. Cell differentiation.


Effects of positive and negative force-contingent reinforcement on the frustration effect in humans.


Body temperature and temporal acuity.

Body temperature and temporal acuity.


Transfer of illusion decrement as a function of perceived similarity.


Effects of two temporal variables on the listener's perception of reading rate.


The time course of lateral asymmetries in visual perception of letters.


Effects of evaluation apprehension on memory over intervals of varying length.


Inheritance of the palomino color in Icelandic horses.


Single-locus control of saccharin preference in mice.


Transformation of a strictly coupled active transport system into a facilitated diffusion system by nystatin.


Aberrant regulation of the Agouti pigment pattern in the viable yellow mouse.


Transinhibition kinetics of the sulfate transport system of Penicillium notatum: analysis based on an iso uni uni velocity equation.


Temporal control of voltage-clamped membranes: an examination of principles.


Separation of sister centromeres in some chromosomes from cultured human leukocytes. A preliminary survey.


Comparison of three selection programs using Tribolium castaneum.


Selection and mutation within and among full-sib lines.


1-Anilino-8-naphthalenesulfonate: a fluorescent indicator of ion binding electrostatic potential on the membrane surface.


A novel synthesis of 4-hydroxycoumarin-3-carboxamides.


Teaching population fitness and adaptive surfaces in population and quantitative genetics.


Interaction of sugar acetals with the human erythrocyte glucose transport system.


1-Anilino-8-naphthalenesulfonate: a fluorescent probe of membrane surface structure, composition and mobility.


Influence of combinations of sexes of children on family size.


Synthesis of some tricyclic nucleosides related to the "Y" base of tRNA.


Hereditary hyperpigmentation anomalies in blacks.


Synthesis and photorearrangement of 4,5-epoxy-4,5-dihydropyrene.


A note on the graphical representation of genetic equilibria. I. Sex-linked genes in random-mating populations.


Steroidal nitrones.

Steroidal nitrones.


Steroidal alkaloids. CLXI. Stereospecific synthesis of (22R)-and (22S)-22-aminocholesterol.


New monoterpenes from Artemisia filifolia (Torrey). Structure, synthesis, rearrangements, and biosynthesis.


Mechanism of cystine racemization in strong acid.


Occurrence of gas phase ammonolysis during chemical ionization mass spectrometry.


Antimetabolites produced by microorganisms. IX. Chemical synthesis of N5-hydroxyornithine and N5-hydroxyarginine.


Synthesis of 1,3,4,5,6,7,8,8a-octahydro-2-methyl-4a-phenylisoquinolin-6-ols. Novel fragments of the morphine molecule.


Estimation of protein in yeast.

Estimation of protein in yeast.


Physical and chemical changes during batch dry rendering of meat meals.


Effect of foliar fungicides on aflatoxin, oil and protein content and maturing rate of peanut kernels.


Biochemical changes in the water-soluble carbohydrates during the development of chicory (Cichorium intybus Linn) roots.


Lack of a response in egg weight or output to increasing levels of linoleic acid in practical layer's diets.


Composition of protein of sorghum grain grown in Botswana.


Non-enzymic browning reactions of ascorbic acid and their inhibition. The production of 3-deoxy-4-sulphopentosulose in mixtures of ascorbic acid, glycine and bisulphite ion.


Non-enzymic browning reactions of ascorbic acid and their inhibition. The identification of 3-deoxy-4-sulphopentosulose in dehydrated, sulphited cabbage after storage.


The dynamic state of liver nucleolar proteins as reflected by their changes during administration of thioacetamide.


A benzilate ester of pyrrolizidine and its stereochemical relationship to other psychotomimetic glycolates.


The relationship of serotonin to a motor disorder of Scottish terrier dogs.


Rapid partial purification of S-adenosyl-L-methionine decarboxylase by affinity chromatography.


The use of DPPD (N,N'-diphenyl-P-phenylenediamine) as an anti-inflammatory agent.


Differential secretion of catecholamines and tetrahydroisoquinolines from the bovine adrenal medulla.


Mercury levels in human brain, skeletal muscle and body fluids.


Stimulation of choline acetyltransferase activity by ethanol in in vitro preparations of rat cerebrum.


Different effects of 1,10-phenanthroline on chronic liver injury induced by dimethylnitrosamine or ethionine in rats.


Alpha-1-acetylmethadol and its N-demethylated metabolites have potent opiate action in the guinea pig isolated ileum.


Dopamine-beta-hydroxylase activity in plasma obtained from the pulmonary artery and left ventricle of man.


Chirality in insect chemoreceptors.

Chirality in insect chemoreceptors.


Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.


Control of the circadian rhythm of the body temperature in the rat.


Effect of chronic treatment with phenobarbital or 3-methylcholanthrene on the male reproductive system in rats.


Inhibitory and inductive effects of piperonyl butoxide on dihydroisodrin hydroxylation in vivo and in vitro in black cutworm (Agrotis ypsilon) larvae.


Blockade of adrenergic responses by halogenated phenyl-2-halogenoethyl amines.


Acetylcholine release from the cholinergic septo-hippocampal pathway.


Conversion of C14-S-adenosylmethionine to C14-formaldehyde and condensation with indoleamines: a side reaction in N-methyltransferase assay in blood.


A theoretical analysis of the binding of bilirubin by human serum albumin: the contribution of the two binding sites.


Long-term testicular responses to blinding in rats.


Cigarette smoke: in vitro effects of condensate fractions on mitochondrial respiration.


Prophylaxis by vitamin C in starvation induced rat stomach ulceration.


Stereospecific binding of narcotics to brain cerebrosides.


The role of binding in inhibition of hepatic microsomal metabolism by parathion and malathion.


Tetrahydropapaveroline: formation in vivo and in vitro in rat brain.


3H-reserpine persistently bound "in vivo" to rat brain subcellular components: limited removal by peanut oil extraction.


Aflatoxins in foods and feedstuffs. 1. The fluorescence micro-method of aflatoxin determination in solution.


Effects of narcotic opiates and serotonin on the electrical behavior of neurons in the guinea pig myenteric plexus.


Adipose tissue and the pathogenesis of obesity (some facts and hypotheses).


Analysis of teat stimulation as specific stimulus for prolactin in cattle.


Time for teamwork.

Time for teamwork.


Bosanquet on contraception.

Bosanquet on contraception.


Psychiatric patients at night. 1.

Psychiatric patients at night. 1.


Nurse education.

Nurse education.


Injuries of the spinal cord: primary nursing management.


Lung cancer.

Lung cancer.


Ectopic gestation.

Ectopic gestation.


A twin pregnancy.

A twin pregnancy.


Timothy.

Timothy.


Future trends in geriatric care.

Future trends in geriatric care.


New style surgery.

New style surgery.


Training pediatricians for primary medical care.


Photodistribution of viral exanthems.

Photodistribution of viral exanthems.


Radiation exposure to personnel in a neonatal nursery.


Urinary tract damage in children who wet.


Australia antigen and neonatal hepatitis syndrome.


Dilemma of trust: relationship between medical care givers and parents of fatally ill children.


The role of the pediatrician in dental caries detection and prevention.


Gingival and periodontal problems in children.


Dental implications of thumb-sucking.

Dental implications of thumb-sucking.


"Brittle" hair with short stature, intellectual impairment and decreased fertility: an autosomal recessive syndrome in an Amish kindred.


The fetoplacental circulation during parturition: evidence from residual placental blood volume.


Early development of children with abnormalities of the sex chromosomes: a prospective study.


Calcium and fat absorption from infant formulas with different fat blends.


Relation of serum cholesterol to in vitro 7alpha-dehydroxylation of primary bile acids by fecal bacteria in infants and children.


Use of serum amylase isoenzymes in evaluation of pancreatic function.


Sacral agenesis.

Sacral agenesis.


The pharmacologic management of status asthmaticus in children.


Letter: Acetaminophen poisoning--a critical comment.


Letter: Are the academicians to blame?

Letter: Are the academicians to blame?


Letter: Intellectual elitism attacked.

Letter: Intellectual elitism attacked.


Letter: Primary medical care and medical research training.


Letter: Health services in the home.

Letter: Health services in the home.


Letter: Viewpoint from the division of community child health.


Letter: Primary health care and medical research.


Letter: School problems and their causes.


Letter: Is Farber's test useful?

Letter: Is Farber's test useful?


Letter: Misconceptions regarding grasshopper allergy.


Tomography--a teaching aid.

Tomography--a teaching aid.


A moving grid which can be attached to a chest stand.


Obstetric radiography at Birmingham Maternity Hospital.


A modified oblique view of the cervical spine.


An experimental course for darkroom technicians.


Filing teaching radiographs.

Filing teaching radiographs.


Desmethylimipramine induced changes in liposomal membrances.


Modification of striatal acetylcholine concentration by dopamine receptor agonists and antagonists.


An autoradiographic study of nickel carcinogenesis in rats following injection of 63Ni3S2 and Ni335S2.


Effects of ethanol on serotonergic neurons in the rat brain.


On the behavioral and neurochemical actions of 6-hydroxydopa and 5,6-dihydroxytryptamine in rats.


Physiologic disposition and metabolism of (3H) ecgonine (cocaine metabolite) in the rat.


Metabolism of cocaine to norcocaine and benzoyl ecgonine by an in vitro microsomal enzyme ststem.


Pharmacological and toxicological studies on 1,4-butanediol.


Cross inhibition of drug metabolism by drug metabolites. Increase of zoxazolamine paralysis time by the major metabolite of diphenylhydantoin.


The effect of close arterial infusion of isoproterenol and phentolamine on the blood flow following short-term and prolonged forearm work.


The transport activity of the cell membrane: some theoretical problems.


Electrooptical effects in membranes.

Electrooptical effects in membranes.


Properties of water in red cell and synthetic membranes.


Relationship between ionic content and ionic transport, short-circuit current and potential difference in the epithelium of toad urinary bladder.


Structure and development of the auditory system in the prothoracic leg of the cricket Teleogryllus commodus (Walker); I. Adult structure.


Structure and development of the auditory system in the prothoracic leg of the cricket Teleogryllus commodus (Walker) II. Postembryonic development.


'Fimbriae' in the fungus Ustilago violacea.


The ultrastructure of the fenestra dorsalis of the syncarid crustaceans Allanaspides helonomus and Allanaspides hickmani.


The ultrastructure of the developing leg disk of Calliphora erythrocephala.


(14C)glutamate uptake and compartmentation in glia of rat dorsal sensory ganglion.


'Steroid psychosis': a case report.

'Steroid psychosis': a case report.


Autoradiographic localization of 3H-gamma-aminobutyric acid uptake in the lamina ganglionaris of Musca and Drosophila.


(3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors.


'2S' RNA, a new ribosomal RNA component in cultured Drosophila cells.


"Counting" of clicks, as reflected in amplitude of potentials evoked in auditory cortex of the dog. In eight dogs with chronically implanted electrodes click-evoked potentials were recorded in the ectosylvian and suprasylvian gyri. During daily sessions clicks were presented in several short trains with a steady interclick interval of 1 s and not followed by any unconditional stimulus. The largest amplitudes resulted from the first and last clicks in the series so that curves plotted for each series assumed a U-shape. Changing the intensity or interclick interval disrupted this pattern.


"Early" large bowel cancer.

"Early" large bowel cancer.


"Precancer" lesions in ulcerative colits. A retrospective study of rectal biopsy and colectomy specimens.


"Pseudoanaphylactic" reactions from inadvertent infusion of procaine penicillin G.


"What's in a name"?

"What's in a name"?


p phenotype in two successive generations of a Japanese family.


[Biological and radioimmunological studies on human prolactin, human growth hormone, and human placental lactogen].


[Editorial: The year ahead].

[Editorial: The year ahead].


[Erythrocyte sedimentation in cattle and buffaloes. A general hypothesis].


[Hereditary spino-cerebellar degeneration and Ramsay-Hunt disease].


[Lesions of vitamin E and selenium deficiencies in poultry and their pathogenesis].


[Production of veal calves with reconstituted milk containing various quantities of fat].


[Radioisotope scanning of the lungs in siderosilicotuberculosis].


[Social values and public health].

[Social values and public health].


A baccalaureate program in toxicology.

A baccalaureate program in toxicology.


A calorimetric study of the lipid phase transitions in aqueous dispersions of phosphorylcholine--phosphorylethanolamine mixtures.


A case of ampicillin-induced haemolytic anemia.


A case of locked twins in uterus bicornis unicollis.


A case of open brucellosis in the dog.

A case of open brucellosis in the dog.


A case of rheumatoid arthritis and haemopericardium.


A cellulolytic rumen bacterium, Micromonospora ruminantium sp.nov.


A cephalometric study of facial types and occlusion classes and relation between them in Finnish children.


A chemotaxonomic survey of essential oil constituents in the tribe Laserpitieae (fam. Umbelliferae).


A centrifugal analyzer with a new all-digital measurement system.


A circular dichroism study of the interaction of adenylic acid oligo- and polynucleotides with TMV protein.


A clinical study of the metabolic effect of a new oral hypoglycemic agent: glipizide.


A clinical experience with intraoperative autotransfusion. Utilizing a disposable unit, intraoperative autotranfusion was employed during surgery in 53 patients admitted to the Bexar County Teaching Hospital at the University of Texas Health Science Center at San Antonio. During the two-year period of study, 26 patients underwent surgery for major traumatic injuries, 8 for ruptured ectopic pregnancy and 19 for miscellaneous emergency or elective conditions. The indication for intraoperative autotransfusion was an anticipated blood loss of 1,000 ml or more. Contraindications for its use were colon injury or localized infection. Over 325 units of blood were salvaged and returned directly to these patients during surgery. One death related to the use of the autotransfusor unit was due to massive air embolism. Twenty other deaths were associated with severe injuries and irreversible shock requiring greater than 3,600 ml of both autologous and homologous blood. Eight of these patients demonstrated severe pancoagulopathies. In the remaining patients, clotting factors and plasma or urine hemoglobin levels were transiently abnormal. However, there were no clinically apparent bleeding defects or renal problems detected. Postoperative blood cultures were consistently negative. It is concluded that intraoperative autotransfusion, when properly employed, is a safe, practical and technically feasible procedure.


A clinico-pathological study of bovine malignant catarrhal fever in Great Britain.


A combined approach to polypectomy via the colonoscope.


A compact and inexpensive drinkometer for use with small animals.


A comparative histological study of the stomach of a few teleost fishes. I.


A comparative study of ball and disc prostheses in mitral valve replacement.


A comparative study of the diagnostic basis for cancer of the colon and cancer of the rectum in Denmark and Finland.


A comparison between fine-needle biopsy and fiberoptic bronchoscopy in patients with lung lesions.


A comparison of baclofen and diazepam in the treatment of spasticity.


A comparison of humoral and cellular immune response to antigenic stimulation in healthy children.


A comparison of enzyme activities in duodenal aspirate following injection of secretin, caerulein, and cholecystokinin.


A comparison of media used in vitro to isolate non-sporing Gram-negative anaerobes from blood. Five anaerobic media were compared in a model blood culture system for their ability to recover small inocula of Gram-negative non-sporing anaerobes. Dehydrated cooked meat medium was the least effective; USP thioglycollate medium was the most effective isolation medium and is recommended for routine use. Freshly prepared cooked meat medium has the advantage of allowing prolonged survival of strains.


A comparison of methods for measuring urinary ammonium.


A comparative study of maximal static strength among male and female California junior high school students in three specific ethnic groups: black, Spanish surname, and white.


A comparison of the bromsulphthalein and galactose elimination test in patients with either chronic bowel inflammation or alcoholic liver disease.


A comparison of the beta 1 and beta 2 effects of subcutaneous isoprenaline, sulbutamol and terbutaline in adult man.


A comparison of the circular dichroism spectra of the subclasses of human immunoglobulin G.


A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practolol. 1 The beta-adrenoceptor blocking agent, acebutolol (M & B 17,803), has been compared with propranolol, practolol, lignocaine and quinidine for its ability to revert or prevent various types of experimental arrhythmias.2 By intravenous infusion, acebutolol had one half the potency of propranolol in reverting an established ouabain-induced ventricular arrhythmia in the anaesthetized dog. Practolol was ineffective in the conditions used.3 High oral doses of acebutolol or propranolol significantly increased the arrhythmic dose of ouabain in the conscious rabbit. Similar doses of practolol produced a significant decrease (i.e. potentiation) in the dose of ouabain required to produce arrhythmia. Lignocaine and quinidine showed no or little activity in this test.4 Propranolol, acebutolol and practolol were all effective in decreasing the frequency of ectopic beats induced by adrenaline and methylchloroform in the anaesthetized cat. Lignocaine and quinidine were only weakly effective.5 Acebutolol and propranolol were equally effective either intravenously or orally in reducing the incidence of ventricular fibrillation produced by chloroform in mice.6 It is suggested that the wide spectrum of experimental anti-arrhythmic activity of acebutolol coupled with its cardioselectivity may make it an interesting compound in the treatment of cardiac arrhythmias in man.


A comparison of the glyceraldehyde 3-phosphate dehydrogenase from ox muscle and liver.


A computer building program for biological structures.


A comparison on the coordination tendency towards Cu2+ of the base moieties in guanosine, inosine and adenosine 5'-triphosphates.


A consumer's view of California's Mental Health Care System.


A contact stimulator for the study of cutaneous thermal sensibility.


A correlation between growth and RNA synthesis in the mouse oocyte.


A critique of Gellhorn and Kiely's mystical states of consciousness.


A cumulative national psychiatric register: its structure and application.


A day hospital program for treating obesity.


A decisional model of recognition applied to the chromosome boundaries.


A difference sedimentation equilibrium technique for measuring small changes in molecular weight. I. Theory and computer simulation.


A diagnostic approach to differentiate brain-damaged from non-brain-damaged adolescents.


A direct gas-chromatographic method for the determination of basic nitrogenous drugs in pharmaceutical preparations.


A difference sedimentation equilibrium technique for measuring small changes in molecular weight. II. Experimental.


A doppler flow probe for canine main left coronary arteries.


A dynamic model of a two-synapse feedback loop in the vertebrate retina.


A fast method for nitrogen determination in single seeds.


A device for nasal irrigation.

A device for nasal irrigation.


A double-blind controlled study of loxapine succinate in the treatment of anxiety neuroses.


A fiber-optic retroreflective turbidimeter for continuously monitoring cell concentration during fermentation.


A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.


A fluorimetric method for the determination of tryptophan in animal tissues. Tryptophan, tryptamine and peptides containing N-terminal tryptophan give two highly fluorescent products on treatment with dithiothreitol and acid ninhydrin reagent 1 or 2. The first fluorescent product (product A) gives an emission at 500nm on activation at 390-400nm and is stable for 20min. The second product (product B), which gives an emission at 530nm on activation at 470nm, is detectable within 1h after the reaction. It gives almost maximum intensity in 4h and is stable for at least 48h. Except lysine, which in equimolar amounts gives less than 1% of a product similar to product B, no other naturally occurring amino compounds give fluorescent products. A procedure is given for the determination of 0.05-34nmol of tryptophan in tissue extracts. By using this procedure rat brain was found to contain 17.56+/-0.76 (s.e.m.) nmol/g wet wt.


A fine structure study of passive transfer thyroiditis.


A follow-up study of female narcotic addicts: variables related to outcome.


A foreign graduate with US training reimmigrates to the United States.


A followup report of a prospective evaluation of vagotomy-pyloroplasty and vagotomy-antrectomy for treatment of duodenal ulcer. A prospective randomized study of 200 consecutive patients who required elective operation for treatment of duodenal ulcer was conducted. Truncal vagotomy and drainage (V-D) was done in 108 patients with a 2% mortality and truncal vagotomy and antrectomy (V-R) were performed in 92 patients with no mortality. Ninety-four per cent of these patients were followed 5-8 years after operation or until their death if that preceded the termination of the study. The immediate postoperative morbidity including stomal dysfunction and reoperation was greater after V-D than after V-R. In the opinion of the patients and independent investigators, the number of gastrointestinal complaints was similar throughout the study for the two groups of patients. In the opinion of the author, however, more gastrointestinal complaints occurred in patients from the V-R group than from the V-D group. Because of the subjectivity involved in the evaluation of these complaints, it is unknown whether a real difference existed between the two groups of patients. No patient in either group was symptomatically disabled after operation. There were nine recurrent ulcers requiring reoperation after V-D and one after V-R. The insulin test was positive in 58% of patients after V-D and 14% after V-R. These figures were essentially unchanged from those in the first report made three to five years after operation. The basal acid output and the response to histalog stimulation also remained unchanged in the two groups of patients during the same period. This study suggests that if one abstains from resection in patients where technical difficulties with the duodenum can be expected, V-R can be performed in the remaining patients with a mortality rate equally as low as that usually reported for V-D. It is concluded that V-R is superior to V-D for the majority of patients because it is associated with fewer recurrent ulcers without a significant difference in the severity of other postoperative gastrointestinal complaints.


A general procedure for the preparation of highly active eukaryotic ribosomes and ribosomal subunits.


A headache history. The key to diagnosis.


A homeostatic mechanism for the removal of antigen from the portal circulation.


A hormonally active substance produced by the ovary of the Holothurian Parastichopus californicus.


A hypokalemic child with paralysis and heart block.


A low-noise thermistor bridge for use in calorimetry.