Regulation of the expression of the reovirus genome in vivo and in vitro.


Panel discussion.

Panel discussion.


Light-induced changes in photoreceptor membrane resistance and potential in Gecko retinas. I. Preparations treated to reduce lateral interactions. The time-course of the light-induced changes in membrane voltage and resistance were measured for single photoreceptors in the retina of Gekko gekko. In the surgically isolated retina, small stimuli directed toward the impaled receptor produced a membrane hyperpolarization the time-course of which was identical to that of the increase in membrane resistance. In the eyecup preparation nearly identical time-courses were evoked only after perfusion of the vitreous surface with solution having high (Mg(++)). Disparate time-courses were obtained in (a) the isolated retina when large or displaced stimuli were used, and (b) the eyecup preparation when it was treated normally (see Pinto and Pak. 1974. J. Gen. Physiol. 64:49) and when it was exposed to aspartate ions or hypoxia. These results are consistent with the hypothesis that the receptor potential (elicited in the impaled receptor as a result of quanta only it captures) is generated by a single ionic process that decreases membrane conductance. These measurements provide a means to distinguish the receptor potential from interactions. From direct measurements of membrane time constant and total resistance in darkness, total membrane capacitance was calculated. The mean capacitance was 7.1 x 10(-5) microF. This high value is consistent with anatomical observations of membrane infoldings at the base of gecko photoreceptors.


Light-induced changes in photoreceptor membrane resistance and potential in Gecko retinas. II. Preparations with active lateral interactions. The time-course of light-induced changes in membrane voltage and resistance were measured in single photoreceptors in eyecup preparations of Gekko gekko. A small circular stimulus directed toward the impaled receptor produced membrane hyperpolarization. Application of a steady annular light to the receptor periphery resulted in diminution of the receptor's response to the stimulus. The effects of illumination of the surrounding receptors were isolated by directing a small, steady desensitizing light to the impaled receptor and then applying a peripheral stimulus. Brief stimuli produced a transient decrease in resistance with rapid onset and offset, a time-course similar to that of the response diminution. For some cells a depolarization that coincided with the resistance decrease was seen. During illumination with prolonged stimuli the resistance decrease was followed by a slow increase. After offset resistance rose transiently above the original value and then returned slowly to its original value. The slow resistance changes were not accompanied by changes in membrane voltage. The response diminution, resistance decrease, and depolarization were not observed in retinas treated with aspartate or hypoxia. It is therefore concluded that these effects are mediated by horizontal cells. The diminution is achieved by shunting the receptor potential and may play a role in field adaptation.


Associative training of Hermissenda.

Associative training of Hermissenda. Reflex behavior of Hermissenda in response to visual and rotational stimuli is described. It is shown that repeated association of light with rotation modifies the subsequent responses of the animals to light. This modification does not occur after the same period of light or rotation alone. The effect of the associative training is strongly dependent on the amount of daily light with which the animals are maintained.


Influence of hypoxia on tidal volume response to CO2 in decerebrate cats.


Oscillations in the discharge of single carotid chemorecptor fibers of the cat.


Some observations on the homogeneity of response of single chemoreceptor fibres.


Chemoreceptor responses to sympathetic stimulation and changes in blood pressure.


A theoretical analysis of the relationship between venous blood and mean tissue oxygen pressures.


Cardiopulmonary responses to carbon monoxide breathing in the chicken.


Oxygen affinity of bird blood.

Oxygen affinity of bird blood.


Effect of histamine on the vertical gradient of transpulmonary pressure.


Influence of breathing rate on airway resistance and compliance measurements.


Expiratory flow rates, driving pressures and time dependent factors, simulation by means of a model.


Laryngeal calibre during hyperthermia in cats.


Evidence of altered regulation of ventilation during exposure to hypoxia.


Prostaglandin E1 effects on ethanol metabolism in the rat.


In vivo insulin secretion: prostaglandin and adrenergic interrelationships.


The binding of prostaglandins to rat liver plasma membranes and its use in the assay of urinary prostaglandins.


Specific PGE1 and PGE2 binding sites in platelet membranes.


Active transport of prostaglandins.

Active transport of prostaglandins.


The effect of salicylic acid on plasma PGA binding and metabolism in the rat.


Organization and ultrastructure of mechanoreceptors (Savi vesicles) in the elasmobranch Torpedo.


The synaptology and cytology of the Clarke cell in nucleus dorsalis of the cat: an electron microscopic study.


Dendro-dendritic synapses in the suprachiasmatic nucleus of the rat hypothalamus.


The mediating role of cognitive development in moral judgment.


Egocentrism and the emergence of conventional morality in preadolescent girls.


The perceptual and cognitive bases for finger localization and selective finger movement in preschool children.


Infants' visual attention to varying degrees of novelty.


Infant recognition memory: the effects of length of familiarization and type of discrimination task.


The early development of inferences about the visual percepts of others.


Auditory short-term memory: developmental changes in rehearsal.


Do children find complex patterns interesting or pleasing?


Synchrony demonstrated between movements of the neonate and adult speech.


Construct standards in skilled action.

Construct standards in skilled action.


Construction of the horizontal, vertical, and oblique by young children: failure to find the "oblique effect".


Development of mechanisms underlying spatial perspectives.


Children's use of component patterns of faces in multidimensional recall problems.


Some pictorial artifacts in studies of African children's pictorial depth perception.


Auditory short-term memory: developmental changes in precategorical acoustic storage.


The distinction between perceiving and memorizing in elementary school children.


Creativity in open and traditional classrooms.


Analysis of lipid disturbances in patients with angiographically confirmed coronary artery disease.


Effect of dietary pectin and algin on the biosynthesis of hepatic lipids in growing rats.


Osteoporosis in Surinam.

Osteoporosis in Surinam.


Effect of low, normal and high dietary protein intake on urinary amino acid excretion and plasma aminogram in children.


Sucrose and hyperlipidaemia. I. The relationship between the plasma lipid concentrations and enzymes of tissue lipogenesis.


Effect of different dietary levels of essential fatty acids on the fatty acid composition of lecithin in rat skeletal muscle.


The satellite bands of the DNA of Drosophila virilis.


Cytogenetics of ticks (Acari: Ixodoidea). 14. Chromosomes of nine species of Asian haemaphysalines.


Reflexes in postganglionic fibres within skin and muscle nerves after mechanical non-noxious stimulation of skin.


Reflexes in postganglionic fibres within skin and muscle nerves after noxious stimulation of skin.


Effect of differential blocking of motor axons on antidromic activation of Renshaw cells in the cat.


Ethnic identity and psychocultural adaptation of Spanish-speaking families.


Comparison of membrane properties of the cell body and the initial part of the axon of phasic motoneurones in the spinal cord of the cat.


Combining behavior modification and group work techniques in a day treatment center.


Applying the helper-therapy principle: a children-teach-children project.


The extended Kalman filter applied to a continuous culture model.


The male genital system in two species of mysid crustacea.


Fine structure of the dorsal ocellus of the worker honeybee.


The functional anatomy of the forelimb of some African viverridae (Carnivora).


Sensory innervation monitoring movement and position in the mandibular stylets of the aphid, Brevicoryne brassicae.


Diagnostic significance of bone marrow biopsy in chronic renal disease.


A modification of the short ammonium chloride loading test in children.


High doses of furosemide and sodium in hypertension. A single therapeutic measure in severe cases.


In vitro performances of stored canine kidneys. Effects of furosemide.


Hospital built with precast modules.

Hospital built with precast modules.


Albumin and alpha-2-macroglobulin clearance: a new approaching method for studying selectivity of proteinuria in unconcentrated urine.


Conflict of interest: constant attention is key to avoidance.


A blueprint for change--part two.

A blueprint for change--part two.


Drug abuse: treatment programs in hospitals.


Preventive and outpatient care stressed.


Patient care conferences.

Patient care conferences.


Discussions meet needs of dying patients.


Vigilance against pathogens.

Vigilance against pathogens.


New unit texturizes, launders garments.

New unit texturizes, launders garments.


A solution to the licensure problem.

A solution to the licensure problem.


Cook-freeze food service: packaging, storage, and transport.


Epithelial cell proliferation during organogenesis of rat colon.


On the synaptogenic sequence in the chick retina.


Uptake of exogenous protein by the preimplantation rabbit.


The production of extracellular connective tissue fibrils by chick notochordal epithelium in vitro.


Effect of continuous darkness on diurnal rhythm in glycogen content in pineal cells of the mouse: a semiquantitative histochemical study.


Breeding activity, preimplantation development, and oviduct histology of the short-tailed fruit bat, Carollia, in captivity.


Analysis of difference between potentials evoked by climbing fibers in cerebellum of cat and turtle.


Prolonged excitatory and inhibitory synaptic modulation of a bursting pacemaker neuron.


Mechanisms of long-lasting inhibition of a bursting pacemaker neuron.


Retinal distribution and central projections of Y-, X-, and W-cells of the cat's retina.


Receptive-field properties of superior colliculus cells and development of visual behavior in kittens.


Circling spreading depression in isolated chick retina.


Liberation of chemical factors during spreading depression in isolated retina.


Synaptic release of radioactivity after intrasomatic injection of choline-3H into an identified cholinergic interneuron in abdominal ganglion of Aplysia californica.


Experiences with trabeculotomy.

Experiences with trabeculotomy.


Ocular use of gentamicin and cephaloridine. I. Intraocular penetration.


Medicolegal aspects of ophthalmology. A symposium held in the Department of Ophthalmology, University of British Columbia, January 14th, 1972.


The macula in diabetes.

The macula in diabetes.


The electroretinogram in macular degeneration.


Conjunctival and corneal changes in chronic renal failure.


Effects of I.D.U. and corticosteroids on corneal epithelium.


Root mean square metering of the human electroretinogram.


Autolysis of the cornea of stored human donor eyes.


Ptosis as a result of trauma.

Ptosis as a result of trauma.


Involvement of immune lymphocytes in corneal reaction against foreign tissue antigen, as determined by leucocyte migration inhibition test.


Avulsion of the inferior rectus.

Avulsion of the inferior rectus.


The corpuscles of stannius and calcium regulation in the North American eel (Anguilla rostrata LeSueur).


Thyroid physiology during the postnatal period in the rat: a study of the development of thyroid function and of the morphogenetic effects of thyroxine with special reference to cerebellar maturation.


Fine structure of the corpuscles of stannius of Atlantic salmon during the freshwater spawning journey.


Environmental calcium and hypocalcin activity in the Stannius corpuscles of the channel catfish, Ictalurus punctatus (Rafinesque).


The effect of weanling and adult males on sexual maturation in female voles (Microtus ochrogaster).


Testicular cycles of the striped racer, Elaphe taeniura.


Respiratory insufficiency in the dog induced by pulmonary microembolism and inhibition of fibrinolysis. Effect of defibrinogenation, leucopenia and thrombocytopenia.


Osteosynthesis of femoral neck fracture using screws.


Old injuries of the ligaments of the knee joint.


Reconstruction of the anterior cruciate ligament by using the medial third of the patellar ligament. Treatment and results.


Primary non-differentiated sarcoma of the liver. Case report and review of the literature.


The immediate influence on serum potassium concentration in hepatic vein and general circulation of liver ischemia.


Gastric ulcer treated with selective proximal vagotomy (SPV). A preliminary report.


Results of different types of operation for pilonidal sinus.


Carcinoma of the stomach. An analysis of 385 cases treated--1955 to 1964.


Transuretero-ureterostomy.

Transuretero-ureterostomy.


Singultus: a case of hiccup with diaphragmatic tumour.


Serologic investigations on the presence of B group arbovirus infections in apparently healthy subjects of several districts in Romania.


Study of some influenza virus strains isolated in Romania during the epidemics of 1971-1972.


Letter: Electron optical aspects of hepatitis antigen.


All 50 states hog cholera free.

All 50 states hog cholera free.


The effect of HB Ag on Nicotiana sylvestris plants.


Determination of sodium content in serum and cerebrospinal fluid as an adjunct to diagnosis of water deprivation in swine.


Surgical induction of keratoconjunctivitis sicca in the dog.


Etorphine and triflupromazine as immobilizing agents in the goat.


Human poisoning with flea-dip concentrate.


Suspect congenital peritoneopericardial diaphragmatic hernia in an adult cat.


Lungworm (Filaroides milksi) infection in a dog.


Veterinarians on faculties of human medicine.


Obtaining support for research on animal health.


Trichinosis in a cat.

Trichinosis in a cat.


Ultrastructure of human uterine epithelium at the time of implantation after postovulatory administration of norethindrone. The impact of postovulatory norethindrone treatment upon the uterine epithelium of normal women at the time of implantation was studied in 7 women for a total of 11 menstrual cycles (3 cycles served as controls).  A total of 150-300 mg norethindrone was administered orally for 2-4 days postovulation.  Plasma progesterone, estradiol, and norethindrone levels were determined daily and an endometrial biopsy was obtained at the expected time of implantation of each cycle for light- and electron-microscopy studies.  No consistent differences were revealed by light microscopy, however, electron microscopy revealed larger mitochondria and the presence of nucleolar channel systems after treatment, suggesting an increased progesteronelike influence in spite  of the decrease in progesterone plasma levels.  It suggested that these structural changes might change the functional properties and thereby impair normal implantation.


Quantitative determination of pulmonary microembolism in the dog. Comparison of in vivo and in vitro methods.


Metabolic aspects of physical training in male patients after myocardial infarction.


Parathyroid hormone and gastric mucosal surface ultrastructure.


Choice of variables for predicting the heart volume.


Improved polymeric contrast agents for roentgenologic examination of the gastrointestinal tract. I. Preliminary report on the chemistry of the polymers.


Improved polymeric contrast agents for roentgenologic examination of the gastrointestinal tract. II. Preliminary report on animal investigations.


Calf diarrhea control in a dairy operation.


Malpractice suits--the growing threat.

Malpractice suits--the growing threat.


Light, texture, shape--and much, much more.


Osteoclastoma in a mare.

Osteoclastoma in a mare.


Radiographic interpretation.

Radiographic interpretation.


Clinical chemistry in equine practice.

Clinical chemistry in equine practice.


The effect of arginine vasotocin on blood volume, plasma protein and electrolyte concentrations in the cockerel, Gallus domesticus.


Strain differences in the erythrocyte and spermatozoan head dimensions of White Leghorn cocks.


An open circuit respirometer for metabolic studies on the domestic fowl: establishment of standard operating conditions.


Nitrovin and tetracycline: a comparison of their effect on salmonellosis in chicks.


An investigation of the effects of feeding beta-aminopropionitrile on the growth rate and intramuscular collagen content of broiler chicks.


Is the hospital library a luxury or a necessity?


Synthesis of milk fat from beta-hydroxybutyrate and acetate in lactating goats.


Alternative conceptions of accountability.


Unmet patient needs.

Unmet patient needs.


Mental health treatment simulates daily living.


Christian affirmation of life.

Christian affirmation of life.


Determination of endogenous vitamin B12 level in the blood serum of children with viral hepatitis using 57CoB12.


Study of the amino acid metabolism in a case of hereditary intolerance to fructose.


Intrapulmonary mixing in chronic bronchitis and emphysema.


Crayfish CNS: minimal degenerative-regenerative changes after lesioning.


Origin of the dental lamina in the regenerating salamander jaw.


Fluid reabsorption in the crayfish kidney labyrinth.


Electron microscopy of kinetochores in whole mount spreads of mitotic chromosomes from hela cells.


The neurotrophic influence on RNA precursor incorporation into polyribosomes of regenerating adult newt forelimbs.


Hypercortisolaemia and lack of skeletal response to oestrogen in postmenopausal women.


Long-term administration of medroxyprogesterone acetate (MPA) to acromegalic patients.


Circadian rhythm of plasma corticosteroids in congenital adrenal hyperplasia.


Measurement of bone mineral and body composition by the attenuation of three low-energy radiations from 241 Am.


A comparison of the effects of subcutaneous orciprenaline, salbutamol and terbutaline in asthmatic children.


The occurrence of circulating anticoagulants in patients with syphilitic and biologically false positive antilipoidal antibodies.


Low dose lynestrenol as a contraceptive influence on ovarian function.


The prediction of cancer incidence in Finland for the year 1980 by means of cancer registry material.


Effects of dietary docosenoic acid upon rats in cold.


A comparative trial of salbutamol and isoprenaline in asthma.


Biochemical and physiological studies of certain ticks (Ixodoidea): isolation and partial identification of a new fatty acid in eggs of Dermacentor andersoni stiles (Ixodidae).


Bile acid metabolism in mammals. VI. Effect of ethionine upon bile acids of rat bile.


Effect of phospholipase A upon brain cholesterol ester formation.


Absorption of corticosteroids from the rat lung.


Metabolism of progesterone by rat brain, pituitary gland and other tissues.


Preparation of 3-deoxy-3-deuteroestrone and 3-deoxy-4-14C-estrone.


The fate of estriol in dogs.

The fate of estriol in dogs.


Nuclear pores in ventricular muscle cells from adult hypertrophied hearts.


Intracellular calcium and myocardial contractility. V. Calcium uptake of sarcoplasmic reticulum fractions in hypertrophied and failing rabbit hearts.


Aggregates of tubules in human cardiac muscle cells.


Ultrastructural analysis of left ventricular hypertrophy in rabbits.


Letter: Nuclear pores in the human myofiber.


Simultaneous chemical stimulation of the hypothalamus and dorsal hippocampus in the waking cat.


Alcohol-induced state-dependent learning in non-alcoholics.


Atropine, scopolamine and hippocampal lesion effects on alternation performance of rats.


Effects of cyproterone  acetate on growth and feeding in rats.


Effects of ethanol and sherry on the performance of a conditioned response in the rat.


Amphetamine-induced taste aversion: a comparison of d- versus l-amphetamine.


Effect of barbiturate anesthesia on discharge pattern in nucleus reticularis thalami.


A comparison of the stimulus effects of morphine and lysergic acid diethylamide (LSD).


Effects of olfactory bulb section on brain noradrenaline, corticosterone and conditioning in the rat.


Marijuana produced changes in cutaneous sensitivity and affect: users and non-users.


Action of intrahypothalamic 6-hydroxydopamine on motivated responding for food and water in the rat.


Oxotremorine antagonism by prolyl-leucyl-glycine-amide administered by different routes and with several anticholinergics.


Disruptive effects of epinephrine on active avoidance behavior: alteration by scopolamine and d-amphetamine.


Parameters influencing the effect of delta9-THC on activity wheel behavior.


Lack of tolerance development to the dipsogenic actions of barbital.


Interacting effects of handling and d-amphetamine on avoidance learning.


Editorial comment: Surgery of the arthritic knee.


The role of arthroscopy in the management of the arthritic knee.


Synovectomy of the knee in rheumatoid arthritis.


Meniscectomy in osteoarthritis.

Meniscectomy in osteoarthritis.


The Pridie debridement operation for osteoarthritis of the knee.


Femoral condylar hemiarthroplasty of the knee. Review and follow-up study.


The place of tibial arthroplasty in reconstruction of the arthritis knee.


Complications of fixation in intertrochanteric fractures.


Results of synovectomy in children with rheumatoid arthritis.


Avascular necrosis of the talus, scaphoid, and metatarsal head in systemic lupus erythematosus.


A study of growth in girls with adolescent idiopathic structural scoliosis.


Hemangioma of the extremities.

Hemangioma of the extremities.


Metastatic lesions of the hand and forearm.


Intraosseous lipoma of os calcis. Case report and review of literature of intraosseous lipoma of extremities.


The value of angiography in the surgical management of deep hemangiomas.


The anatomy and function of the proximal tibiofibular joint.


Subluxation of the proximal tibiofibular joint.


Boot top fractures of the fibula.

Boot top fractures of the fibula.


Hyperparathyroidism in an elderly adult with hypophosphatasia.


Electromyography of hallux valgus.

Electromyography of hallux valgus.


Posterior interosseous nerve compression. Report of a case caused by traumatic aneurysm.


Peroneal nerve palsy as a complication of clubfoot treatment.


Aseptic necrosis of the talus. Revascularization after bone grafting.


Pathologic changes in the idiopathic painful cup arthroplasty.


The urinary excretion of calcium. An analysis of the distribution of values in relation to sex, age and calcium deprivation.


Letter: Synovectomy and autologous vaccine for rheumatoid arthritis.


18F scintigraphy of non-neoplastic skeletal lesions. A preliminary report.


Letter: The fate of simple bone cysts which fracture.


General introduction to cytochemical hormone bioassay.


Technical aspects of the redox bioassay for luteinizing hormone.


The need for more sensitive assays for the measurement of thyroid-stimulating hormone (TSH) and the long-acting thyroid stimulator (LATS).


Studies on thyroid stimulating hormone and the long-acting thyroid stimulating hormone.


The arrangement of microtubules and the attachment of chromosomes to the spindle during anaphase in tipulid spermatocytes.


Cytogenetical survey of black rats, Rattus rattus, in Southwest and Central Asia, with special regard to the evolutional relationship between three geographical types.


Mammalian cell fusion. V. Replication behaviour of heterochromatin as observed by premature chromosome condensation.


Phase transformation and chiasma frequency variation in locusts. I. Schistocerca gregaria.


The influence of ecdysterone on gene amplification, DNA synthesis, and puff formation in the salivary gland chromosomes of Rhynchosciara hollaenderi.


Phase transformation and chiasma frequency variation in locusts. II. Locusta migratoria.


The Bombyx mori genome: analysis by DNA reassociation kinetics.


Chromosome variation in British populations on Oncopsis (Hemiptera: Cicadellidae).


On Le Fort I osteotomy; A follow-up study of 106 operated patients with maxillo-facial deformity.


The ultra-low temperature autoradiography of water and its solutes.


Radiological study of canine stomach cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine.


A new method for producing adenocarcinomas in the stomach of dogs with N-ethyl-N'-nitro-N-nitrosoguanidine.


Effect of various carcinogenic and non-carcinogenic substances on development of bladder tumors in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosoamine.


Changes in ANS and TNS fluorescence in giant axons from Loligo.


Computer simulation of sodium fluxes in frog skin epidermis.


Computer simulation of the response of frog skin epidermis to changes in (Na plus)0.


Evidence for beta-turn analogs in proline peptides in the solid state. An infrared study.


New method for calculating the conformational entropy of a regular helix.


Computer simulation of Na wash-out kinetics in frog skin epidermis.


Transport of ions of one kind through thin membranes. 3. Current-voltage curves for membrane-soluble ions.


A double thermal helix-coil transition.

A double thermal helix-coil transition.


Influence of conformational isomers on the circular dichroism of poly(L-prolyglycine).


Intrinsic viscosity of wormlike chains. Determination of the shift factor.


Effects of cations on ouabain binding by intact human erythrocytes.


The effect of phloretin on the potassium conductance in Aplysia giant neurons.


An intergenic alcohol dehydrogenase isozyme in sunflowers.


The interaction of fluorescent probes with anion permeability pathways of human red cells.


Kinetic characteristics of monoamine oxidase and serum cholinesterase in several related rat strains.


A genetic analysis of peroxidase isozymes in two species of Nicotiana.


The pressure-dependence of the hydraulic conductivity, the membrane resistance and membrane potential during turgor pressure regulation in Valonia utricularis.


Components of the major urinary protein complex of inbred mice: determination of NH2-terminal sequences and comparison with homologous components from wild mice.


Cell-to-cell diffusion of procion yellow in sheep and calf Purkinje fibers.


Potassium conductance models related to an interactive subunit membrane.


Salivary gland enlargement in acromegaly.


Dialysis bone disease. A quantitative histologic study.


Membrane effects mediated by alpha-and beta-adrenoceptors in mouse parotid acinar cells.


Removal of iodinated contrast material by peritoneal dialysis.


Plasma calcium and the optimum dialysate calcium concentration during maintenance haemodialysis.


The influence of renin on the intrarenal distribution of blood flow and autoregulation.


The renal excretion of hydrogen ions in infants and children.


Gross hematuria as a manifestation of advanced glomerular disease.


Use of metolazone, a new diuretic, in patients with renal disease.


Successful treatment of unilateral renal vein thrombosis with heparin following venous catheterization and insertion of a polyethylene catheter.


Arsenic contamination of drinking water and foodstuffs causing endemic chronic poisoning.


Congenital Letterer-Siwe disease.

Congenital Letterer-Siwe disease.


Permeability of the bovine red cell to glycerol in hyperosmotic solutions at various temperatures.


Survival of frozen-thawed bovine red cells as a function of the permeation of glycerol and sucrose.


Membrane proteins related to anion permeability of human red blood cells. II. Effects of proteolytic enzymes on disulfonic stilbene sites of surface proteins.


The effect of electrical stimulation on the action of sulfhydryl reagents in the giant axon of squid: suggested mechanisms for the role of thiol and disulfide groups in electrically-induced conformational changes.


Membrane proteins related to anion permeability of human red blood cells. I. Localization of disulfonic stilbene binding sites in proteins involved in permeation.


Dimensions of polar pathways through rabbit gallbladder epithelium. The effect of phloretin on nonelectrolyte permeability.


Na+-dependent amino acid transport in plasma membrane vesicles from Ehrlich ascites cells.


Particle-bound phytochrome: a function of light dose and steady-state level of the far-red-absorbing form.


Precipitation membranes. II. Experiments on the electrochemical deconditioning of BaSO4 membranes.


Phase behavior of the binary system tetradecyl amine-water.


Computer graphics in the solution of the chain deformation problem.


A monolayer and freeze-etching study of charged phospholipids. II. Ionic properties of mixtures of phosphatidylglycerol and lysylphosphatidylglycerol.


Calcium-binding of synaptosomes isolated from rat brain cortex. I. Effects of high external potassium ions.


Passive electrical properties of squid axon membrane.


Chemical composition of isolated rat skeletal sarcolemma.


Conformational properties of poly(gamma-hydroxy-L-proline) based on rigid and flexible pyrrolidine rings.


Examination of the electrotropic cholesteric to nematic phase transition of liquid crystal poly(gamma-benzyl-L-glutamate) by Laser light beating spectroscopy.


Interaction of endogenous peroxidase with foreign particles in phagocytizing Kupffer cells.


Surface morphology of irradiated macrophages.


113mIndium-iron colloid for quantitative studies of marrow reticuloendothelial function.


Tissue microvenography of the adrenal in cirrhosis with portal hypertension.


Tendency for patients with peptic ulcer to receive excess medical ionizing radiation.


Sterility in Japanese radiological technicians.


A chemical synthesis of benzylated methyl alpha-isomalto oligosaccharides.


Serum histidine clearance in children with diphenylhydantoin administration.


Application of the lanthanide-induced shifts to the nuclear magnetic resonance determination of the helical conformation of poly(beta-hydroxybutyrate) in solution.


In vivo studies on the de novo synthesis of molecular species of rat lung lecithins.


Total correction of tetralogy of Fallot.


Effects of vitamin E on the aggregation and the lipid peroxidation of platelets exposed to hydrogen peroxide.


Comparison of six analytical methods for blood sugar determination.


A method to produce a narrowing of the coronary artery in the open-chest dog.


Measurement of the wave in the healthy children by using the microvibration on the scalp.


Classical and instrumental conditioning: the general laws of connections between "centers". This is a synopsis of the author's concept of the physiological mechanisms of classical and instrumental conditioning. In the classical conditioned reflex the connection is established between the central representations of the conditioned and unconditioned stimuli while in the instrumental reflex it is established between the representation of the former stimulus and the kinesthetic representation of the instrumental response. Drives play an important role in both types of conditioning by providing aroma1 in the corresponding neural centers.


Conditional reflex theory and motivational behavior. Motivational behavior is explained in the light of reflex theory by reference to: (i) Pavlov's concept of nerve center as an assembly of structures messing the same function, (ii) Sherrington's and Magnus' ideas about the hierarchical structure of the nervous system, (iii) author's notion about the multistage arc of the unconditioned reflex, i.e., an arc with many branches in its central path, each passing through the main integrative levels of the central nervous system, (iv) experimental facts of this laboratory and particularly concerning bidirectional conditioned connections. It is assumed that motivational behavior elicited by endogenous and exogenous factors through hereditary mechanisms may be regarded as a manifestation of complex inborn reflexes, in which the main branch is located in the limbic system. The cortical branch makes it possible to elaborate particular conditioned reflexes. Physiological mechanisms of so-called purposive movements in motivational behavior is regarded as the activity of backward conditioned connections, leading from the unconditioned reflex centers to the centers controlling motor effectors.


On the role of the hippocampus in the integrative activity of the brain. The present evidence plus data from the literature suggest that the hippocampus is concerned with responses to signals having low probability of reinforcement. The theta-rhythm, characteristic of the hippocampus, arises in a situation of pragmatic uncertainty, when stereotypical behavioral patterns have not yet been formed and when decisions are still being sought. The theta-rhythm may serve as a correlate only of orienting-exploratory responses and not as a correlate of the orienting-defensive responses of "biological alertness", in Pavlov's terminology. Functionally, the hippocampus belongs to the system of structures which make decisions about the response to a given stimulus. If, following destruction of the hippocampus, the neocortex gives preference to signals with high probability of reinforcement and in the sphere of unconditioned responses a stronger motivation is predominant, then hippocampal involvement is essential for simultaneous assessment of these two factors. For that reason, the hippocampus plays an important role in the competition among conditioned reflexes having different magnitudes and reinforcement probabilities.


Detection of cell-mediated immunity to measles virus with 51Cr release cytotoxic assay in patients with natural measles.


Quality of stimuli and prefrontal lesions effects on reversal learning in go-no go avoidance reflex differentiation in cats. Go  no go avoidance reflex differentiation of two acoustic stimuli has been previously established in cats. Then the signalling properties of the conditioned stimuli were reversed and the course of acquisition of a new go-no go differentiation was studied in normal cats and in cats with prefrontal lesions. The hypothesis based on stimulus intensity dynamism theory was: (i) in normal cats acquisition of the new differentiation would be easier if the more effective stimulus of the pair were used as the positive stimulus, and (ii) in prefrontal cats this effect of stimulus quality would be l a or absent. Results confirmed both predictions. The differences in rapidity of reversal learning were almost exclusively due to differences in responding to the new positive stimulus. Prefrontal cats were not deficient in comparison with normal cabs in their inhibitory abilities in spite of the fact that extinction of bar-pressing to the new negative conditioned stimulus was much slower than trader of the avoidance response to the new positive stimulus. At the beginning of reversal learning two opposite changes in responding on no-go trials were observed: (i) a decrease in the number of long-latency responses, which reflected the changed signalling value of the previously positive stimulus, and (ii) an increase in the number of short-latency responses, which was positively correlated with the increase in rate of intertrial responding. The increases in number of short-latency responses to the new negative stimulus and in rate of intertrial responding observed at the beginning of reversal learning were smaller in prefrontal than in normal cabs. Results of the experiment indicate that the "drive disinhibition hypothesis" does not account for the effects of prefrontal lesions on avoidance behavior.


On the functional stucture of conditioned reflexes to serial stimuli in dogs. The functional structure of conditioned reflexes to a stimulus series has been studied. The serial stimulus consisted of a tone of 600 Hz, passive lifting of the right forepaw, and a puff of air directed at the eye, the latter component of the series being reinforced by food. Four dogs were wed. Objective registration of the effector manifestations to each component stimulus has shown that, during the elaboration of a conditioned alimentary reflex to the serial stimulus, conditioned connections are formed by each component with the alimentary center and by each preceding stimulus with all subsequent stimuli, irrespective of their position in the series. All excitation foci which function in the given stimulus set become interconnected. Direct connections of each stimulus component with the alimentary center are never inhibited. The multiplicity of duplicating direct connections and the presence of backward connections impart to composite reflexes the reliability and adaptive strength which is necessary for the formation of behavioral acts.


Effect of use on the elective appearance of an instrumental reaction in dogs. Dogs were used to elaborate two instrumental reactions  flexing the left or right forepaw respectively to pull a dish of food within reach of its mouth. If both paws were simultaneously fixed to levers, dog was faced with a choice between two reactions. In preliminary trials right paw preference was strong despite equal effectiveness of the left paw in obtaining the food. The aim of the experiment was to alter this right paw preference by forcing the use of the left paw. Each ten training trials were followed by a test with free choice of paws. According to the probabilities PL = 0.8 and PR = 0.2, a random table was used to determine the order of forced use of the right or left paw. In all, 1,000 training trials and 100 tests with free choice were carried out on each of three dogs. According to the training program in every 100 training trials the left paw was made to display the reaction a total 80 times, the right paw, 20 times. Absolute alteration in the preference occurred even though in all trials with free choice both forepaws were equally effective in obtaining food. Thus, use as well as condition of reinforcement is important in instrumental conditioning.


Effects of postnatal influences on conditioning and some functional and structural brain parameters in rats. Early postnatal influences were studied in rats in three different ways: (i) different litter size, (ii) feeding with restricted amount of protein, (iii) different level of afferent stimulation. A complex evaluation of spontaneous activity, conditioning, electrophysiological and biochemical analyses was used in these experiments. Medium sized litters showed the greater electrophysiological reactivity (cortical evoked potentials) and the most stable performance in different kinds of conditioning (avoidance) experiments. Animals reared on a low protein diet were subnormal in electrophysiological indices, and had a lower level of biochemical activity for materials Involved in neural excitability, electrogenesis, and cellular and subcellular energetic metabolism (phospholipids, proteins, DNA, RNA). In all respects (behavioral, electrophysiological and biochemical tests) animals with partial sensory deprivation in the postnatal period had the lowest indices. The "stimulated" animals on the other hand were superior to both other groups in the tests used for the analysis of higher nervous activity, but electrophysiological and biochemical analyses did not show clear differences between the "stimulated" and control animals. Optimal development of brain functions requires adequate conditions in the early postnatal period. However, the "adequacy" of them conditions has dill to be determined more precisely.


Metastasis and growth of Friend tumor cells in irradiated syngeneic hosts.


Uronase as a clot lysis agent for acute thromboembolism in the lower extremities.


Functional organization of cortical motor areas in adult dogs and puppies. In adult dogs and puppies ranging in age from 1 day up to 3 months the functional organization of the motor cortex has been investigated with 50 or 60 cycle a-c stimulation under Nembutal anesthesia. In adult dogs two separate, somatotopically organized motor areas have been differentiated (i) the "precentral" motor area (MI) which occupies mainly the rostral half of the gyrus sigmoideus posterior, and (ii) the supplementary motor area (MII) located in the lateral two-thirds of the gyrus sigmoideus anterior. In addition, stimulation of the somatosensory area I (SI) in the caudal half of the gyrus sigmoideus posterior elicited somatic movements. Stimulation of MI produced low threshold, relatively simple movements of the contralateral extremities. Movements obtained from SI were similar, but had much higher thresholds. Stimulation of MII yielded high threshold, complex and often bilateral movements. In puppies up to 3 weeks of age cortical stimulation elicited bilateral movements which showed no definite projection pattern. From the 4th week of life a somatotopic organization and contralateral representation of the body began to appear and then gradually to evolve in the direction of the adult pattern. At the end of the 3rd month movements in puppies were essentially similar to those of adult dogs. However some minor differences were still present, suggesting that the process of maturation of cortical motor areas were not yet completed at this age.


Analysis of visual information in midbrain centers. The role of pretectum and colliculus superior in the analysis of visual information was studied. Single unit responses to visual stimuli were recorded. Several types of responses were observed, including "suppressed by contrast", "direction non-sensitive" and "direction sensitive" responses. An attempt was made to define the place and mechanism of direction-sensitivity of the cell. The conclusion is put forward that horizontal cells in the first layers of retina are not responsible for direction-sensitivity. Detailed analysis of receptive field structure revealed "homogeneous" and "heterogeneous" types of receptive fields as shown by response patterns of the neuron to a flashing light spot positioned in different parts of the receptive field. Study of latency distributions also revealed both complex "heterolatent" and more simple "homolatent" organizations of receptive fields The effect of the intensity of background illumination was investigated. Results show that changing of the background illumination can influence the response pattern of a cell, and sometimes can influence the direction-sensitivity.


Changes in direct cortical response during elaboration of conditioned defensive reflex. A classical conditioned defensive reflex to direct, electric stimulation of the cerebral cortex was elaborated in dogs. The conditional stimulus (CS) was provided by electric stimulation of the middle suprasylvian gyrus at 1 Hz. Electrocutaneous stimulation of a forepaw served as the unconditional stimulus. During elaboration of CRs changes in the direct cortical response (DCR) were studied by recording them on an ink-recording electroencephalograph and a cathode oscilloscope with the use of averaging and superimpositions. The composition of the DCRs depended on stimulation site and intensity. Prior to conditioning, the DCRs contained either 2-3 components or a series of positive-negative potentials which often filled in the entire interval (1 s) between the stimulating pulses. When the cortical stimulation had acquired defensive significance, DCRs with a series of late components filling in the entire inter-pulse interval became much less frequent. Concurrently, the amplitude of late DCR components decreased during exposure to the CS. During elaboration of CRs the frequency of late DCR components also increased. All those phenomena were more strongly marked during electrocutaneous stimulation of the forepaw. The character of DCRs was found to depend on the dog's state; when alert, with activated EEG, late DCR components were few in number and low in amplitude, while in a calm state with a predominance of slow rhythms, DCRs with a series of late components frequently occurred and usually had a large amplitude.


Recovery of emotional behavior after lesions of the septal area. Temporary decortication induced by acute cerebral ischemia or insulin coma reinstated the initial syndrome of emotional hyperreactivity in rats fully recovered from septal forebrain lesions. The effect was virtually the same as observed earlier with the use of spreading cortical depression. Surprisingly it was found that insulin coma induced during the acute phase of the septal syndrome but not after regression facilitated the recovery of normal emotional behavior. It is postulated that the observed effects of temporary decortication do not result from transient abolition of cerebral functions but rather from the disorganizing action of functional decortication, which consists of disruption of old and freshly formed neural connections.


Membrane potential in the isolated papillary muscle of rats with experimental myotonia.


Hyperglycemia, diabetes and coronary heart disease.


Atherosclerosis and thrombosis.

Atherosclerosis and thrombosis.


Study on the risk factors of coronary heart disease in family aggregates of Verona.


Deficiency of plasma humoral recognition factor activity following burn injury.


Low level immunoglobulin production by mitogenically stimulated rabbit lymphocytes.


Histology of the local cellular response of ducks to injections of antigenic material.


Phagocytosis of sheep erythrocytes by macrophages: a study of the attachment phase by scanning electron microscopy.


Studies of opal mutations in bacteriophage T4B.


Dynamics of immunoglobulin and alloantigens on lymphocytes.


Ultraviolet light sensitive mutants of Coprinus lagopus. I. Isolation and characterization.


Comparison of sister chromatid exchanges from three successive cell cycles in Wallabia bicolor chromosomes.


Effect of sodium fluoride on radiation sensitivity of barley seeds.


Chromosome aberration peristence in swine leukocytes following exposure to fission neutrons.


Repair of x-ray damage in aging WI-38 cells.


Repair synthesis and induction of thymidine-resistant variants in mouse lymphoma cells of different radiosensitivity.


Repair mechanisms in mamalian cells.

Repair mechanisms in mamalian cells.


Conceptual preference in children: task-specific findings.


Effects of competence and nurturance on imitation of nonretarded peers by retarded adolescents.


Habituation of orienting response to simple and complex stimuli.


Conditioned eyelid response, peripheral vasoconstriction, and attention in retarded and nonretarded individuals.


Imagery mediation in paired-associate learning by retarded and nonretarded subjects.


Facilitation of semantic integration in sentence memory of retarded children.


Intensity modulation and the reproduction of auditory duration by nonretarded and retarded children.


Play therapy with institutionalized mentally retarded children.


Effects of external emphasis and redundancy level on the paired-associate learning of retarded adolescents and nonretarded children.


Statistical realities of special-class distributions.


Holding a retarded boy at a table for 2 minutes to reduce inappropriate object contact.


Social reinforcement and knowledge of results as determinants of motor performance among EMR childern.


Effects of institutionalization upon word modeling responses of retarded subjects.


Structure-of-intellect categories in Stanford-Binet performance.


Isolation of salivary ribonuclease, deoxyribonuclease and amylase from the parotid gland of the rat, Rattus norvegicus albinus.


The purification of porcine heart lactate dehydrogenase by affinity chromatography.


Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta.


Purification and properties of an amine oxidase in bovine dental pulp and its comparison with serum amine oxidase.


Esterases from the midgut and gastric caecum of the American cockroach, Periplaneta americana (L.). Isolation and characterization.


The binding sites for substrate and effectors on glycogen phosphorylase b.


The effect of ammonium sulfate on the activity of ribonuclease A.


Regulatory and physicochemical properties of two isoenzymes of malate dehydrogenase from Schizosaccharo-myces pombe.


Fetal face syndrome with acral dysostosis.


Testicular volume during adolescence. Cross-sectional and longitudinal studies.


Phrenoblysis: special brain and mind growth periods. I. Human brain and skull development.


Septal damage during the maturation of inhibitory responding: effects in juvenile and adult rats.


Early experience, ultrasonic vocalizations, and maternal responsiveness in rats.


The effects of vitamin A excess administered during the mid-fetal period on learning and development in rat offspring.


Early restriction of tactile stimulation and visual functioning in the kitten.


Developmental changes in the rate of ultrasonic vocalization in the mongolian gerbil.


Escape learning: acquisition and extinction rates as a function of age in rats.


Effect of hemorrhagic shock on tissue adenine nucleotides in conscious rats.


Preferential "binding" of gamma-aminobutyric acid and glycine to synaptosome-enriched fractions of rat cerebral cortex and spinal cord.


The effects of hydrostatic pressure on the elastic properties of cat veins.


The elastic properties of the human great saphenous vein in relation to primary varicose veins.


Is the peripheral utilization of glucose a regulator of hepatic glucose production and of glycemia?


Components of glucose transport in the host-parasite system, Hymenolepis diminuta (Cestoda) and the rat intestine.


Early dissociation of protein synthesis and amylase secretion following hormonal stimulation of the pancreas.


Estimation of hepatic glucose output in non-steady state. The simultaneous use of 2-3H-glucose and 14C-glucose in the dog.


Interscapular location of brown adipose tissue: role in noradrenaline-induced calorigenesis in cold-acclimated rats.


The effect of a single large dose of cyclophosphamide on erythropoiesis and iron metabolism in mice.


Factors related to the dive reflex in harbor seals: respiration, immersion bradycardia, and lability of the heart rate.


Factors related to the dive reflex in harbor seals: sensory contributions from the trigeminal region.


Platelet-surface interaction: effect of albumin coating or heparin complexing on thrombogenic surfaces.


Uptake, storage, and release of gamma-aminobutyric acid in normal and chronically denervated cat cerebral cortex.


Effect of acute and chronic pretreatment with delta1-tetrahydrocannabinol on motor impairment by ethanol in the rat.


The action of cholecystokinin and related peptides on guinea pig small intestine.


The effect of prostaglandin E1 on lipid metabolism and hormone secretion in sheep.


Aryldiazonium salts as antagonists at cholinergic muscarinic receptors.


Bile flow and composition during bile acid depletion and administration.


Effect of calcitonin on P uptake in epiphyseal cartilages of P-deficient rats.


Variations in the relative potencies of bronchodilators in the presence and absence of carbachol-induced tone.


The influence of testosterone on the endogenous levels of prostaglandin F in the accessory reproductive glands of the adult male rat.


Evidence of complementary afterimages in the pigeon. Key pecking of pigeons was reinforced on a variable-interval schedule when ambient illumination came from a green light, but not when it came from a red, yellow, or white light. The different hues were randomly presented for periods of 30 sec each, with the restriction that white never followed red. After discriminative control was established, the pigeons were tested with the same procedure used during training, except that white sometimes followed red. Significantly more responses were made during white-following-red than during white following either green or yellow. These findings indicate that, in changing from red to white, complementary afterimages can be induced in pigeons for a brief period of time. By providing behavioral evidence for afterimages in the pigeon, this technique may be useful to research in comparative neurophysiology, animal discrimination learning, and theories of color vision.


Hunger and contrast in a multiple schedule. Pigeons working for food on a multiple variable-interval 1-min-variable-interval 4-min schedule were subjected to variations in body weight, presumably causing changes in hunger. The proportion of responses in each component approached and eventually reached the proportion of reinforcements as body weight increased. This effect follows from the matching-law interpretation of contrast in multiple schedules.


A detailed analysis of the effects of d-amphetamine on behavior under fixed-interval schedules. Pigeons were exposed to fixed-interval schedules of food reinforcement with durations of 300 sec, 100 sec, or 40 sec. A range of doses of d-amphetamine was administered to each pigeon, and the resulting behavior was analyzed at several levels of detail. Average rates in different portions of the intervals predicted the magnitude of the drug's effect, but a finer analysis showed that average rates did not adequately characterize the behavior in some parts of the intervals. The probability of responding in different parts of an interval without drug was also a good predictor of the magnitude of the effect of d-amphetamine, and at the same time was more descriptive of the interval-to-interval performance. Analyses of the control performance indicated that responding in individual intervals could be described as consisting of two parts: a very low, or zero, rate at the beginning of the interval followed by an abrupt transition to a slightly, but reliably, positively accelerated rate maintained until reinforcement.


Changes in progressive-ratio performance under increased pressures of air. Rats performed on progressive-ratio schedules that required an increasing number of responses for each successive reinforcement. The number of responses required increased until the subjects failed to complete the next ratio in the sequence within 15 min. Response-ratio increments of two responses, five responses, and 20 responses were investigated. The size of the final completed ratio generally increased with increases in the progressive-ratio step size. Increased pressures of air in a hyperbaric chamber led to both increases and decreases in terminal ratio size, with the differential effects depending on both air pressure and on the size of the progressive-ratio increment. Changes in the number of responses in the final ratio were related to increased pressures of nitrogen, as similar pressures of helium produced few effects.


Contingency spaces and measures in classical and instrumental conditioning. The contingency between conditional and unconditional stimuli in classical conditioning paradigms, and between responses and consequences in instrumental conditioning paradigms, is analyzed. The results are represented in two- and three-dimensional spaces in which points correspond to procedures, or procedures and outcomes. Traditional statistical and psychological measures of association are applied to data in classical conditioning. Root mean square contingency, Ø, is proposed as a measure of contingency characterizing classical conditioning effects at asymptote. In instrumental training procedures, traditional measures of association are inappropriate, since one degree of freedom-response probability-is yielded to the subject. Further analysis of instrumental contingencies yields a surprising result. The well established "Matching Law" in free-operant concurrent schedules subsumes the "Probability Matching" finding of mathematical learning theory, and both are equivalent to zero contingency between responses and consequences.


Mediated transport of nucleosides in human erythrocytes. Specific binding of the inhibitor nitrobenzylthioinosine to nucleoside transport sites in the erythrocyte membrane.


Studies on human polymorphonuclear leukocyte enzymes. 3. Differential activation of primary and specific granules by phospholipase C and deoxycholate.


Transport of amino acids in rat pancreas during development.


On the stability of the liquid-crystalline lamellar lecithin-water system.


Studies on the transport of glucose from disaccharides by hamster small intestine in vitro. II. Characteristics of the disaccharidase-related transport system.


Biochemical changes in Bifidobacterium bifidum var. pennsylvanicus after cell-wall inhibition. VI. Biosynthesis of the galactosyldiglycerides.


The interrelation of glucagon and gonadectomy upon hepatic triglyceride metabolism in rats.


Phospholipases in human seminal plasma.

Phospholipases in human seminal plasma.


The structure of phospholipids and triacylglycerols containing long-chain iso acids in the porpoise Tursiops gilli.


Effects of fatty acids on the oxidative metabolism of leukocytes.


Occurrence of saturated and mono-unsaturated fatty acids with unusually-long-chains (C20-C30) in Lactobacillus heterohiochii, an alcoholophilic bacterium.


Reduction of prostaglandin E2 to prostaglandin F2alpha by an enzyme in sheep blood.


Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates.


Detergent ingestion unique experience of a family.


Drug identification by imprint.

Drug identification by imprint.


Enhanced renal tubular secretion of meprobamate: role of saline-furosemide diuresis.


Five years with 5 million child-resistant containers.


Activated charcoal preparations--relative antidotal efficacy.


New liquid lye drain cleaners.

New liquid lye drain cleaners.


Characterization and mating reactions of clinical isolates of Trychophyton mentagrophytes and T. rubrum which produce a diffusible brownish pigment.


The incidence of hospitalized cases of systemic mycotic infections.


Distribution of the genus cryptococcus in Souther California soils.


Taxonomy and identification of mucormycosis-causing fungi. I. Synonymity of Absidia ramosa with A. corymbifera.


Studies on the purification of prothrombin from bovine plasma.


Studies on rat specific thymocyte antigen (RSTA).


The nature of the venous systems in the adrenal gland.


Change of levels of urinary organic mercury in groups with varying extents of inorganic mercury exposure.


Histological findings and amylase contents of the pancreas and parotid gland of rats with experimental obstruction of the common bile duct.


Platelet aggregation by platelet-clumping substance.


Isolation and chemical analyses of platelet-clumping substance in blood.


Isolation and characterization of multiple forms of human thrombin.


Vascular injury and thrombosis: a scanning electron microscopic study.


Polyphloretinphosphate, an antithrombogenic substance which inhibits platelet adhesion.


Progressive inactivation of factor VII in the cold by heparin.


Proteolytic specificity of thrombin.

Proteolytic specificity of thrombin.


An electrostatic computer model of a biological membrane.


Computer applications for health care facility design.


A data acquisition and processing system for the ultraviolet optical ultracentrifuge.


Prostaglandin production by experimental tumours and its inhibition by non-steroidal-anti-inflammatory drugs.


The distribution of prostaglandins in inflammatory exudates.


Restriction of transmitter release from adrenergic nerves mediated by prostaglandins and alpha-adrenoreceptors.


The failure of indomethacin to modify the response of cat small intestine to cholera enterotoxin.


Effects of inhibition of prostaglandin biosynthesis on noradrenaline release from isolated perfused spleen of the cat.


The role of prostaglandins in several allergic and inflammatory process.


Hyperthermic effect of intraventricular injections of arachidonic acid and prostaglandin E2 in the rat.


Adrenergic neuroeffector junctions sensitive and insensitive to the effect of PGE.


The influence on prostaglandin synthetase system by 1-aryl-4-carboxy-2-pyrrolidones in relation to their pharmacological activity.


Effects of prostaglandins on experimental arrhythmias.


The release of prostaglandin-like substances during reactive and functional hyperemia in the hind leg of the dog.


Interactions between isoproterenol and prostaglandin E2 in the dog heart in situ.


Studies on the buoyant density of a feline calicivirus.


Esters and carbamates of 4-dialkylamino-1,2-diphenyl-3-methyl-2-butanols with coronary dilator activity. Note II.


Effect of indomethacin on vascular responses to vasoactive agents in working skeletal muscles in the dog.


Microelectrophysiological analysis of the cardiac effect of prostaglandin E2.


The reaction of 3-formylrifamycin SV with sulphonium and phosphonium ylides.


Possible role of prostaglandins in cardiac electrogenesis.


The role of prostaglandin in fertility regulation.


The effects of prostaglandin A2(PGA2) on the fuinea-pig isolated ileum.


Pharmacological effects of compounds similar to prostaglandins.


The study of guinea-pig gallbladder reactivity after PGE1 stimualtion.


Gas chromatographic-sensory parallel chracterisation of methionine-glucose reaction products and their relation to meat aroma.


The influence of prostaglandin A2 (PGA2) on distribution of sodium in the organs of the rat.


A gas chromatographic analysis of monocarbonyl compounds and amines in the volatile components of wheaten bread.


Prostaglandin synthetase activity in the renal medulla of normal and hypertensive rats.


Direct effects of the prostaglandins E1 and E2alpha on the activity of pancreatic triglyceride lipase.


The effect of prostaglandin E1 on exocrine pancreatic secretion (in vivo and in vitro).


Preservation of mango juice by freezing and canning.


Health planning in Appalachia: conflict resolution in a community hospital.


Premature social aging: the social-psychological consequences of a chronic illness.


Lullabies in the Maternity Hospital.

Lullabies in the Maternity Hospital.


More about the drug problem.

More about the drug problem.


Colposcopic findings in contraception.

Colposcopic findings in contraception. This editorial emphasizes the need for colpophotography to be done with colposcopy; otherwise the findings cannot be considered convincing.  By colpophotography changes can be recorded that occur with cervical carcinoma as well as the changes that are demonstrated in some women who have taken oral contraceptives over a long period.  The changes found after the use of an intrauterine device are totally unremarkable.  With the combination pill hyperplastic-polypoid and edematic ectopies are formed.  With the sequential pill there is a different kind of characteristic change - extended ectopies with extreme vascularization.  Early pregnancy followed by uninterrupted oral contraception is also found to cause changes.


Colposcopic aspects of management of vaginal adenosis in DES children. This report presents evidence from clinical experience of the etiological role of in utero exposure to diethylstilbestrol (DES) in vaginal adenosis of children and adolescents.  Figures depict the histological pattern of adenosis lesions, and a brief history of research and serendipity leading to the causal hypothesis is reviewed.  This research included 2 retrospective studies of pediatric vaginal carcinoma (circa 1927 and 1963) as well as current studies.  The study summarized here was prompted by the author's extensive use of DES for high-risk pregnancy management and his resultant attempt to locate patients exposed in utero during his practice.  Office records since 1948 were reviewed, comprising 10,051 charts.  Using colposcopy, 20 respondents to a questionnaire have been examined, and 17 had varying degrees of vaginal or cervical abnormalities.  The mothers of all cases with severe adenosis (n=9) received more than 100 mg daily during the first trimester of pregnancy.  All 20 mothers had received from 15-600 mg daily.  In the 3 patients without adenosis, 1 mother was treated daily with 15 mg, starting Day 78;  the second was treated with 15-25 mg daily, starting on Day 28;  and the third was treated with 100 mg daily for only 5 days on Day 67-72 of gestation.  2 case reports are published.  The treatment method recommended is to remove all abnormal epithelium from the top of the vagina under colposcopic guidance in the operating room under general anesthesia or in the office with local anesthesia;  a small Eppendorfer biopsy instrument should be used to "weed the garden."


Dysplasia and cancer in situ of young patients: colposcopic and cytological observations.


Colposcopic aspects of endocervicitis.

Colposcopic aspects of endocervicitis.


The non-protein thiol of rat liver mitochondria.


The incorporation of the carboxyl carbon from acetyl coenzyme A into ring A of quercetin by cell-free extracts prepared from buckwheat seedlings.


Absence of significant rates of gluconeogenesis in intestinal mucosa of starved guinea pigs.


Phantom limbs and the body schema.

Phantom limbs and the body schema.


Comparison of two inhibitors of beta-glucuronidase from porcine sublingual and submaxillary glands.


Methoxyflurane nephrotoxicity.

Methoxyflurane nephrotoxicity.


The effect of pancuronium bromide on plasma nor-epinephrine concentrations during ketamine induction.


Effects of intravenously administered solutions on electrolytes and energy substrates during surgery.


Effect of thiopentone on emergence reactions to ketamine anaesthesia.


A redesigned anaesthetic gas machine.

A redesigned anaesthetic gas machine.


Haematological and cardiorespiratory responses to induced hyperpyrexia.


A proposed national curriculum in anaesthesia.


An aid to epidural puncture.

An aid to epidural puncture.


Anaesthesia for intra-laryngeal laser surgery.


Pre-intestinal carotene losses in sheep fed alfalfa or isolated carotene beadlets.


Effect of vitamin A deficiency on several bone parameters in chicks.


Vitamin A nutrition and its relationship with plasma cholesterol level in the patients with cancer.


Effect of feeding excess of vitamin A and vitamin C on liver, plasma and adrenal lipids of rats.


The excretion of 17 oxosteroids by rats deficient in vitamin E.


The thiamine status of patients with cancer as determined by the red cell transketolase activity.


Dietary vitamin intake and thiamine and riboflavin nutritional status in two rural population groups of Italy.


Vitamin C intake and plasma level among aged people in Finland.


Intestinal transfer and hepatic incorporation of amino acids in rats fed various carbohydrates.


Use of the fluorescent dye, pyrene, to study the dynamic aspects of membrane structure.


Microfluorometry of primary and secondary fluorescence in biological tissue.


Digital microspectrofluorometry by multichannel scaling and single photon detection.


The stomach of the pangolin (Manis pentadactyla) with emphasis on the pyloric teeth.


Pyramidal connections to the lateral reticular nucleus in the cat: a degeneration study.


Growth changes in the mandible of the ox.


Anatomy and mechanism of distension of the dulaa of the one-humped camel.


The effect of pinealectomy on the parafollicular cells of the rat thyroid gland.


Microangiographic aspects of the thebesian veins.


In vivo incorporation of L-(3H)arginine into proteins of anterior pituitary gland and hypothalamus of intact and castrated rats.


A developmental time scale for postnatal changes in brain and behavior of B6D2F2 mice.


An autoradiographic study of ventral lateral geniculate projections in the cat.


Dissociation of retinal fibers by degeneration rate.


Survival times and patterns of degeneration in the visual system of the opossum.


Activation of group IV afferent units from muscle by algesic agents.


A scatter diagram for displaying the response of sensory neurons to sinusoidal stimulation.


Trigeminal PAD as disynaptically evoked by stimulation of the trigeminal sensory branches.


Depression of the afterhyperpolarization in dorsal spinocerebellar tract neurones.


Dual processes control response habituation across a single synapse.


Choline uptake by nerve terminals: a sensitive and a specific marker of cholinergic innervation.


Inhibition of the jaw opening reflex by electrical stimulation of the periaqueductal gray matter in the awake, unrestrained cat.


Effects of alpha-methyl-p-tyrosine upon cerebral amine metabolism and sleep states in the cat.


Requirement for adrenal glucocorticoid in the ethanol-induced increase of tryptophan hydroxylas activity in mouse brain.


Injuries of the spine in children and adolescents.


Mechanical analysis of techniques for improved correction of idiopathic scoliosis.


Recurrent dislocation of the elbow in children.


Pyogenic infections of the sacroiliac joint in children. Radioisotope bone scanning as a diagnostic tool.


Deforming non-erosive arthritis of the hand in systemic lupus erythematosus.


Synovectomy for rheumatoid arthritis.

Synovectomy for rheumatoid arthritis.


False aneurysm of the profunda femoris artery resulting from nail-plate fixation of intertrochanteric fracture. A case report and review of the literature.


Fractures of the distal third of the femur treated by internal fixation.


Tendon transfer for radial rotation of the wrist in rheumatoid arthritis.


Metatarsal osteotomy for bunionette deformity.


Turret exostosis of the phalanges.

Turret exostosis of the phalanges.


Ambulant, nonoperative management of femoral shaft fractures. I.


Ambulant, nonoperative management of femoral shaft fractures. II.


Bilateral total knee replacement in a patient with sickle cell disease.


Intramedullary fixation of the fractured tibia with Lottes nail.


Embryonal rhabdomyosarcoma of the hand. A case report.


Blastomycosis osteomyelitis.

Blastomycosis osteomyelitis.


Piezoelectricity and autoinduction.

Piezoelectricity and autoinduction.


In vitro effect of weak direct current on Staphylococcus aureus.


The cardiovascular effects of methylmethacrylate in dogs.


Total surface hip replacement in the dog. A preliminary study of local tissue reaction.


Variables affecting the friction and wear of metal-on-plastic total hip joints.


The structure of polymethylmethacrylate cement.


Prosthetic devices for partial replacement of damaged small joints. An experiment in dogs.


New improved bone cement (MMA-TBB).

New improved bone cement (MMA-TBB).


A study of the wear resistance of a prosthesis for the metacarpophalangeal joint of the thumb.


Fixation of loose bodies in joints.

Fixation of loose bodies in joints.


A calcium kinetic approach to the problem of renal osteodystrophy.


Experimental pulmonary bone marrow embolism. Fate of marrow emboli and the development of pulmonary arteriosclerosis.


The pathogenesis of the subchondral pseudocysts in rheumatoid arthritis.


Corticosteroid injection effects on the biomechanical properties of rabbit patellar tendons.


Zonal osteons in cortical bone.

Zonal osteons in cortical bone.


Effect of chronic administration of glucocorticoid (prednisolone) on the rate of healing of experimental osseous defects.


Effect of ethane-1-hydroxy-1, 1-diphosphonate on bone turnover in adult dogs.


Effects of fluoride on phosphatase activity and ash content of metaphyseal bone of the rat.


Movement of the sacroiliac joint.

Movement of the sacroiliac joint.


The effects of parathyroid hormone on bone cell structure and function.


Dialysis. Introduction.

Dialysis. Introduction.


Pounds. 2. Apply"pounds. 2. Apply.

Pounds. 2. Apply"pounds. 2. Apply.


Effect of electrolytes on the solubility and solubilization of chlorocresol.


The hard-water syndrome.

The hard-water syndrome.


Dialysate composition and function: the effects of water content.


Effect of electrolytes on the partial molal volume of non-ionic surfactants.


Effect of electrolytes on the partition coefficient of chlorocresol and sulphadiazine.


Solubilization of tetracycline and oxytetracycline.


Bone disease in patients dialyzed with untreated water.


Delivery of a public water supply: standards, safeguards, and differences.


Effect of solubilizers on the stability of tetracycline.


[The use of spectroscopic methods in pharmaceutical analysis. 4. Determination of bismuth, aluminum, magnesium, calcium, titanium and silicon in antacids using atomic absorption spectrophotometry].


Reverse osmosis: the mechanism and application to dialysis.


Isolation of cantharidin from Epicauta tomentosa.


Eimeria dalli sp. n. (Protozoa: Eimeriidae) from Dall sheep Ovis dalli.


The fine structure of the colonial kinetoplastid flagellate Cephalothamnium cyclopum Stein.


Dialysis membranes: cellulose acetate compared with other available membrane materials.


Fine structure of Trypanosoma cyclops in noncellular cultures.


Light and electron microsopic observations on the pathogenesis of Naegleria fowleri in mouse brain and tissue culture.


Selectivity of ingestion and digestion in the chrysomonad flagellate Ochromonas malhamensis.


The structure and origin of mastigonemes in Ochromonas minute and Monas sp.


Phototaxis by the dinoflagellate Gymnodinium splendens Lebour.


Cell division in Gonyaulax catenella, a marine catenate dinoflagellate.


An infectious agent associated with amebas of the genus Naegleria.


The contractile vacuole in Amoeba proteus: temperature effects.


Results of blood transfusions from donor rabbits infected with Eimeria stiedai to recipient coccidiafree rabbits.


Induction of temperature sensitivity in Paramecium aurelia by nitrosoguanidine.


Specificity of amino acid transport in Trypanosoma equiperdum.


Isolation of the kinetoplast DNA of Leishmania tarentolae in the form of a network.


Dihydrogolate reductase in Plasmodium lophurae and duckling erythrocytes.


The division of depressive illness into depression spectrum disease and pure depressive disease.


Stepwise synthesis of oligonucleotides. Synthesis of trinucleoside diphosphates catalyzed by a nonspecific ribonuclease from Penicillium brevicompactum.


Kinetics of the alpha-chymotrypsin-catalyzed hydrolysis of N-ACETYL-L-phenylalanylglycine amide in the equilibrium state: profit of an acylenzyme mechanism.


Regulatory action of near UV light on the development of Ectothiorhodospira shaposhnikovii carotenoids as possible sensitizing pigments.


The possible conformation of immunoglobulin G1 (Eu).


Investigation of the serum albumin sites binding methyl orange and changes in the binding of the dye during heating and the action of trypsin.


Fractionation of DNA of pigeon reticulocytes according to nucleotide composition and renaturation kinetics.


Catalytic properties of 4'-substituted analogs of pyridoxal-5'-phosphate and pyridoxamine-5'-phosphate in the reaction of model and enzymatic transamination.


Theory of the elementary act of enzymic reactions with transfer of two charges.


Low-molecular-weight RNAS in loach embryogeny.


The renal reabsorption of glucose in the developing canine kidney: a study of glomerulotubular balance.


Transport of L-methionine in rat intestine and kidney.


Arginine esterase in cystic fibrosis of the pancreas.


Chromosomal mosaicism in diagnostic amniotic fluid cell cultures.


Letter: Cystic fibrosis ciliary inhibitor.


Routine endoscopic photography simplified.


Endoscopy procedures and their combined application in gynecology.


Tolerance to the hyperactivating effects of methylamphetamine.


Recovery from electroconvulsive shock-induced amnesia by exposure to the training environment: pharmacological enhancement by piracetam.


Cocaine, pemoline and amphetamine on learning and retention of a discrimination test in mice.


Physiological disposition of beta-phenylethylamine, 2,4,5-trimethoxyphenylethylamine, 2,3,4,5,6-pentamethoxyphenylethylamine and beta-hydroxymescaline in rat brain, liver and plasma.


Typing of Rhizobium meliloti mutants by means of phages.


Ether extracts from the fruiting body of Piptoporus betulinus as interference inducers.


Pediatric psychopharmacology and the language-learning impaired child.


Suggested minimal requirements for clinical supervisors.


Speech science and speech pathology in Sweden.


[Certain indicators of hemodynamics in school children with chronic focal infection].


My experience in anorectal surgery during the past 25 years.


Toxic principles of Hippomane mancinella.


Production of secondary metabolites in plants cell cultures.


Biological and chemical assay of geniposide, a new laxative in the fruit of Gardenia.


Ultrastructure of the "Cannabis sativa" glands.


Estimation of the alkaloids of Rauwolfia caffra.


Quantitative fluorimetric determination of the main cardiac glycosides in Digitalis purpurea leaves.


Purgative activities of iridoid glucosides.


Identification and distribution of p-tyramine in the rat.


Nuclear proteins during development: incorporation of leucine into histones of rainbow trout during early development.


Patterns of incorporation of (32P)orthophosphate and (3H)acetate into histones of rainbow trout during early development.


Patterns of incorporation of (3H)leucine and (32P)orthophosphate into nonhistone proteins of rainbow trout during early development.


Synthesis of albumin with exogenous mouse-liver messenger RNA in a homologous cell-free system.


The amino-acid sequence of the alkali light chains of rabbit skeletal-muscle myosin.


Use of mass spectrometry and quantitative Edman degradation for the determination of repeating amino-acid sequences.


Bovine rhodopsin: characterization of the complex formed with Triton X-100.


Reaction mechanisms of indole-3-acetate degradation by peroxidases. A stopped-flow and low-temperature spectroscopic study.


Characterization of an endoribonuclease in rat-liver nucleoli.


Characterization of ribonucleic acid components from leaves of Phaseolus aureus.


Ornithine-delta-transaminase heterogeneity and regulation. Sequential expression of the "liver" and "kidney" enzyme forms during the HeLa cell cycle.


Ribosomal RNA precursors and the synthesis of chloroplast and cytoplasmic ribosomal ribonucleic acid in leaves of Phaseolus aureus.


Bovine-lens leucine aminopeptidase. Kinetic studies with substrates and substrate-like inhibitors.


Mechanisms of energy coupling to the transport of amino acids by Staphylococcus aureus.


Studies on methylmalonyl-CoA mutase from Propionibacterium shermanii.


Stereochemistry of C-1,2-dehydrogenation during cholesterol degradation by Mycobacterium phlei.


The fine structure of the sinus node in the rat.


Substrate competition in human myocardial metabolism.


Chemical energy and cardiac work.

Chemical energy and cardiac work.


Factors affecting efficiency of cardiac contraction.


Assessment of myocardial function by echocardiography.


Assessment of myocardial performance in man with heart disease.


The His bundle electrogram in impaired atrioventricular conduction.


Haemodynamic effects of arrhythmias: effects of alterations in ventricular rate on cardiac output and peripheral flow distribution.


Surgery of coronary obstruction.

Surgery of coronary obstruction.


The kinetics of plasma free fatty acid and triglyceride transport in patients with idiopathic hypertriglyceridaemia and their relation to carbohydrate metabolism.


The mechanism of action of clofibrate and tetranicotinoylfructose (Bradilan) on the kinetics of plasma free fatty acid and triglyceride transport in type IV and type V hypertriglyceridaemia.


Glucose-6-phosphate dehydrogenase (G-6-PD) Hamburg, a new variant with chronic nonspherocytic haemolytic anaemia.


Dibromsulphalein (DBSP) estimation of hepatic transport function in man.


Influence of portacaval shunt on bile formation in the rat.


Influence of body position on the anginal threshold during leg exercise.


Measurement of and correction for incubation damage in radioimmunoassay.


Human calcitonin radioimmunoassay in normal and pathological conditions.


Editorials: Planning international contact among epidemiologists.


Developments in Australia's health services.


Prevalence and natural history of lung disease in New South Wales schoolchildren.


The identification and treatment of hypertensives in two Australian urban communities.


Casualty care in car crashes.

Casualty care in car crashes.


The Traralgon health and illness survey. 2. Prevalence of illness and use of health care.


Q fever in Cyprus report of cases and a survey of United Nations personnel.


Ethnic differences in lung function: evidence for proportional differences.


Corrections for sampling bias in the epidemiological survey of a chronic disease.


Letter: Exchange visits by epidemiologists.


Measuring the use of health services by household interviews: A comparison of procedures used in three child health surveys.


Letter: Crash courses in epidemiology.

Letter: Crash courses in epidemiology.


Formation and treatment of cerebral edema.


Unilateral hydrocephalus. Case report.

Unilateral hydrocephalus. Case report.


Convexity meningioma presenting angiographically as "pseudo-subdural hematoma". Report of a case.


Spontaneous spinal epidural hematoma.

Spontaneous spinal epidural hematoma.


Genetics of chemical induction of conjugation in Paramecium aurella. Certain stocks of P. aurelia, syngen 8, could not be induced to conjugate in a solution (KCl + acriflavine + calcium-poor conditions) which was effective in inducing conjugation in other species of Paramecium as well as in other stocks of syngen 8. Both stocks could conjugate by interaction with cells of complementary mating type. Breeding analysis shows that each of the two stocks is homozygous for a recessive gene that blocks induction of conjugation by the KCl-acriflavine solution. These two genes are neither allelic nor linked. Analyses of the phenotypes of the two uninducibles and the wild type were carried out by attempting to induce mating in cells of a single mating type by exposing them to detached mating-reactive cilia from cells of complementary mating type and to the KCl-acriflavine solution, either sequentially or simultaneously. The results confirm the conclusions of others that there is at least one unique step in chemical induction not shared with induction by interaction of complementary mating types. But the results also indicate that there is more than one unique step in chemical induction and that the effects of the two genes described here operate during different periods of the hour required for chemical induction.


Hairpin-tail: a case of post-reductional gene action in the mouse egg. Hairpin-tail (T(hp)) is a new allele of brachyury on chromosome 17 (linkage group IX) of the mouse. The morphological effects in the heterozygote are on the notochord and the tail. The homozygous abnormal is unknown. T(hp) is unique in that the phenotype of the heterozygote seems to depend on the source of the T(hp) gene. If it is inherited via the egg the phenotype is extreme and death follows in utero. Embryos derived from a T(hp) sperm and a+egg are less abnormal and viable. This is not a simple maternal effect, as T(hp)xT(hp) matings produce two distinct types of heterozygous embryos.


Cold temperature resistance, chromosomal polymorphism and interpopulation heterosis in Drosophila pseudoobscura. Descendants of two Colorado, U.S.A., populations of D. pseudoobscura, Boulder and La Foret, were exposed to +2 degrees and -2 degrees . In third instar larvae from Boulder AR and PP third chromosome gene arrangements survived better than TL and others, while the reverse situation occurred for La Foret. Deleterious dominant effects were observed for AR from La Foret. In adults from Boulder there was a trend towards greater survival for AR and PP than for other gene arrangements, while AR from La Foret showed relatively poor cold resistance. Survival of Boulder and La Foret flies, and their interpopulation hybrid, was determined after exposure to -2 degrees at two humidities. Order of survival of developmental stages was: adults >> third instar larvae > mixture of first and second instar larvae. Adults survived better at low humidity, while larvae survived better at high humidity. Boulder adults and larvae survived better than those from La Foret. Advantage in survival of hybrids over the midparent ranged from 23% to 138%. Hybrid advantage over the higher parent ranged from 5% to 111%. Order of expression of heterosis was: mixture of first and second instar larvae > third instar larvae > adults. Relation of all results to the chromosomal polymorphisms at Boulder (seasonally constant) and La Foret (seasonally cyclic) is discussed.


An experimental comparison of individual, family and combination selection. Two selection experiments comparing the relative efficiencies of individual, family, and combination selection were conducted. The expected results for larval weight of Tribolium (h(2) = 0.20) and for pupal weight (h(2) = 0.40) were that combination selection would be a more efficient method than family selection, and that family selection would exceed individual selection. In experiment I, individual selection produced more response (P < 0.05) than did combination or family, which was not in agreement with expectation. There was confounding of inbreeding levels and random drift due to differential effective population sizes in the lines selected by different methods. Experiment II consisted of ten single-generation selection tests. An advantage of this approach is that it eleminates the inherent problems of differential inbreeding levels and differential rates of genetic drift due to unequal population sizes among the methods of selection. There were no statistically significant differences in efficiency among the three methods of selection for both traits. This was contrary to theoretical expectations but does suggest that with traits of 20% h(2) or higher, and where feasible, one may be justified in basing selection decisions on the phenotype of the individual only. Other advantages of single generation testing are that it allows more precise testing of selection theory and unbiased standard errors for estimates of realized heritability.


A general model to account for enzyme variation in natural populations. Approximate conditions for genetic polymorphism in temporally and spatially varying environments are presented for loci which are intermediate at the level of fitness or at the level of gene function. The conditions suggest that polymorphism will be more likely in more variable environments while unlikely in constant environments. Biochemical evidence is presented to justify the assumption of heterozygote intermediacy. Observations on natural populations are cited which substantiate the claim that allozymic polymorphism is primarily due to selection acting on environmental variation in gene function.


Electronystagmography on normal persons.


Source of the P1 component of the cochlea round window recording.


The effect of visual input on post-rotatory nystagmus in normal children.


Ultrastructure of the epithelium in atrophic rhinitis. Scanning electron microscopic studies.


The vascular anatomy of the rhesus monkey cochlea.


Distribution of the crossed olivo-cochlear bundle terminals in the squirrel monkey cochlea.


Fingerprinting of eukaryotic ribosomal RNA labelled with tritiated nucleosides.


A procedure for the separation of glucosamine from glucosaminitol.


A microassay for arylamidase activity.

A microassay for arylamidase activity.


Determination of uronic acid content of saccharides by acidic decarboxylation: a simplified procedure.


Chemical-ionization mass spectrometry of lincomycin and clindamycin.


Derivatization and gas chromatographic determination of some biologically important acids in cerebrospinal fluid.


A modified amino acid analyzer with greater versatility.


Assay of liver microsomal cholesterol 7 alpha-hydroxylase using deuterated carrier and gas chromatography-mass spectrometry.


A simple automatic dispensing apparatus.


An automated apparatus for quantitative aliquot measurement of phosphorylated intermediates.


Gas-liquid chromatographic determination of antibiotic X-537A, lasalocid.


Micropolyamide thin-layer chromatography of phenylthiohydantoin amino acids (PTH) at subnanomolar level. A rapid microtechnique for simultaneous multisample identification after automated Edman degradations.


On the analysis of fluorescence decay kinetics by the method of least-squares.


The separation of certain bases, nucleosides, and nucleotides related to adenine by continuous-flow electrophoresis.


Separation of isoprenoid alcohols and aldehydes by thin-layer chromatography.


Arterial cell kinetics in experimental hypertension.


Early morphological alterations of the rat lung with increased intracranial pressure. I. A light and electron microscopic study.


Morphogenesis of traumatic ventricular septum ruptures of the heart.


Changes of extracellular potassium concentration induced by neuronal activity in the sinal cord of the cat. 1. Changes of extracellular K(+) concentration, [K](e), arising in the spinal cord of the cat in response to an afferent stimulation were studied by means of K(+)-specific micro-electrodes.2. In the most active areas of the spinal cord a single volley in a large afferent input like the common peroneal nerve or the posterior tibial nerve produced a transient increase in [K](e) of 0.05-0.1 mM, which reached its peak in 0.2-0.3 sec and it declined in about 3 sec.3. Much higher increases in [K](e) were found during repetitive stimulation of an afferent input. The highest increase (by 3 mM) was at 100 Hz, but even at 1 Hz a significant increase of 0.25 mM was observed. Equilibration of accumulated K(+) was slow with a time constant of about 6 sec, which is much longer than could be expected for the same process in free solution.4. A characteristic distribution of increased [K](e) was found in the spinal cord in response to 100 Hz afferent stimulation. The highest increase of 3 mM was found in and around the intermediate nucleus, but at depths between 0.9-1.8 mm the [K](e) increase exceeded 1 mM.5. In the ventral horns afferent stimulation (100 Hz) increased [K](e) by 0.25 mM, while the same stimulation of the ventral root resulted in a [K](e) increase of less than 0.05 mM.6. The consequences of K(e) (+) accumulation after neuronal discharge are discussed in respect to its possible role in the depolarization of primary afferent terminals.


Cardiovascular alterations associated with bursts of panting in the exercising dog. 1. In conscious dogs exercising on a treadmill variations in arterial blood pressure and heart rate which were correlated with bursts of panting were observed. The blood pressure variations reflected similar variations in the total peripheral vascular resistance.2. During exercise a change in respiration from slow breathing to panting was followed by a systemic vasodilatation and fall in blood pressure, but a rise in heart rate. Analysis of the time course of these effects demonstrated that the heart rate increase occurred later than the blood pressure fall.3. The correlation between panting and blood pressure changes was not abolished by either of the receptor-blocking drugs atropine sulphate or propranolol, nor by either of the following surgical procedures: acute bilateral cervical vagotomy, and denervation of the carotid sinus baroreceptors and carotid body chemoreceptors.4. The vasodilatation which followed a burst of panting appeared to be due to a decrease in adrenergic vasoconstrictor sympathetic nerve activity, and not to a change in the chemical composition of the arterial blood.5. It is concluded that the vascular changes are not reflex responses to stimulation of peripheral receptors by the bursts of panting. Instead, it is suggested that both the bursts of panting and associated falls in blood pressure are parallel effects resulting from activation at a suprabulbar level of the central nervous system. It is also concluded that the variations in heart rate are mediated by the baroreceptor reflex mechanism, activated by the changes in mean blood pressure.


Analysis of non-linearity observed in the current-voltage relation of the tunicate embryo. 1. In the gastrula of the tunicate (Halocynthia aurantium) the resting potential of the embryonic membrane was about -70 mV in both std ASW and Na-free ASW.2. The potential responses to depolarizing current in the early gastrula embryo showed distinct potential jumps from about -50 to about +40 mV during the application of current and from about 0 to resting level after its cessation thus forming a plateau at about 0 mV. Those jumps were not altered significantly by the removal of both Na and Ca ions from ASW except for the duration of the plateau after the cessation of current.3. Blastomeres in an embryo were tightly coupled with each other electrotonically at the blastula and gastrula stages. The fact that the coupling ratio was nearly 1.0 made it reasonable to treat an embryo as one cell as far as electrical properties are concerned.4. The I-V relation of the embryonic membrane consisted of an inward rectifying region, outward rectifying region and transitional zone between the two, resulting in a S-shaped curve as in the egg cell membrane. But in the gastrula embryo, the transitional zone actually included the discontinuous part of the I-V curve (from about -50 to about +40 mV) due to the potential jump.5. The ionic current (I(i)) during the potential jump in Na-free ASW was estimated from the slope of the potential response based on the assumption of constant capacitance during the membrane potential changes. The calculated I(i)-V curve complemented the interrupted I-V curve smoothly and showed the existence of a negative resistance region from about -50 to about 0 mV in the steady-state I-V relation.6. The steady-state I-V relation was altered significantly by changing the K concentration in ASW, and the existence of the negative resistance can be reasonably explained by the marked inward-going rectification or anomalous rectification of K conductance.7. The replacement of K with Rb in ASW produced the marked suppression of the inward-going rectification of the embryonic membrane.


The formation of synapses in regenerating mammalian striated muscle. 1. A histological and electrophysiological study has been made of the formation of synapses in soleus and extensor digitorum longus muscles of adult rats regenerating from minced muscle fragments.2. In the first 8 days of regeneration, myoblast and myotubes formed within the basement membranes of degenerating myofibres.3. Eleven- to fourteen-day regenerates contained fasicles of myotubes and myofibres and both nerves and spontaneous miniature end-plate potentials (m.e.p.p.s) were observed for the first time, although very few synapses show evoked end-plate potentials (e.p.p.s).4. Eighteen- to twenty-six-day regenerates contained. myofibres on which only a single end-plate could be detected; 30% of these synapses had a normal amplitude-frequency distribution of m.e.p.p.s and subthreshold e.p.p.s whilst at the remainder the e.p.p. was either suprathreshold or did not occur.5. Thirty- to sixty-day regenerates contained myofibres and end-plates with the same morphological and functional characteristics as those in normal muscle.


Mechanism of anion permeation through the muscle fibre membrane of an elasmobranch fish, Taeniura lymma. 1. Properties of anion permeation through the membrane of skeletal muscle fibres of the stingray, Taeniura lymma, were studied with intracellular recording and polarization techniques.2. The Cl conductance of the resting membrane in the normal stingray saline at pH 7.7 is 8-10 times greater than the K conductance.3. The Cl conductance decreases with decreasing external pH, with an apparent pK of 5.3, whereas the K conductance is independent of pH between 4 and 9.4. The Q(10) of the Cl conductance is about 2.0, compared with a value of 1.2-1.4 for the K conductance.5. The Cl conductance is proportional to the external Cl concentration when observed after the fibre is equilibrated in the test solution.6. The permeability sequence obtained by potential measurement is SCN > NO(3) > Cl = Br > I > ClO(3) and the permeability ratio is independent of the mole fraction of anions.7. The conductance sequence determined by total replacement of the external Cl with other anion species differs from the permeability sequence and the conductance observed for partial replacement deviates significantly from that expected from the independence principle.8. Possible mechanisms of anion permeation are discussed.


A nervous mechanism for descending inhibition in guinea-pig small intestine. 1. Intracellular recordings were made from neurones in the myenteric plexus of guinea-pig small intestine under conditions in which these neurones received synaptic input from an adjacent segment of intestine.2. Most long synaptic pathways in the myenteric plexus were found to lead in an anal direction.3. Such pathways could be excited by either distension or transmural electrical stimulation of the intestinal segment.4. Similar stimuli evoked inhibitory junction potentials in the circular muscle layer but only on the anal side of the stimulated region of intestine.5. The results are discussed in relation to the concept of descending inhibition (Bayliss & Starling, 1899).