Sites of competition in the selective hepatic uptake of rifamycin-SV, flavaspidic acid, bilirubin, and bromsulphthalein. In rats both rifamycin-SV and flavaspidic acid impaired the disappearance of bromsulphthalein (BSP) from plasma. The addition of rifamycin-SV to rat liver supernatant containing BSP did not displace BSP from ligandin or Z protein unless it was added in very high concentration. In similar studies in vitro with flavaspidic acid, BSP was displaced from Z protein even at low concentrations of flavaspidic acid, whereas there was only a minor effect on the binding to ligandin. The intravenous administration of rifamycin to Gunn rats raised the plasma bilirubin concentration slightly after 30 minutes whereas flavaspidic acid was without significant effect. At 30 minutes the amount of bilirubin in the liver was markedly reduced by rifamycin and moderately depressed by flavaspidic acid. Although both the rifamycin and flavaspidic acid lowered the bilirubin in cell sap, the main effect of flavaspidic acid appeared to be on binding to Z protein. Rifamycin reduced the amount bound to both ligandin and Z protein. It is suggested that flavaspidic acid acted on the hepatic uptake of bilirubin and BSP predominantly by competing for binding to Z protein. Rifamycin-SV acted at a different site, probably blocking uptake at the plasma membrane.


Ocular dimensions and the heredity of open-angle glaucoma.


Relationship of outcome of treatment to agreement about treatment assignment by patients and professionals.


Labor relations among professional groups.


Basic considerations in prescribing diets.


Letter: Reducing diets.

Letter: Reducing diets.


Surgical management of corrosive gastric injuries. Four cases of extensive corrosive gastric injury requiring surgical treatment are presented. Appropriate management of this life-threatening entity requires an awareness of its subtle presentation plus a well planned surgical approach.


Splenic vein thrombosis with oesophageal varices: a late complication of umbilical vein catheterization. On the basis of observations made on three infants, a description is given of a late complication of umbilical vein catheterization not hitherto reported. The children showed the symptoms of thrombosis of the splenic vein with secondary splenomegaly and marked gastric and/or esophageal varices, while the portal vein showed no abnormality. The diagnosis was preoperatively established by means of selective angiography of the superior mesenteric artery and the splenic artery. Treatment in these three cases consisted of splenectomy, with good clinical and radiological results.


Neoplasms of the small bowel.

Neoplasms of the small bowel. Small bowel tumors are unusual lesions exhibiting nonspecific clinical features often diagnosed at an advanced stage. In the cases studied at the Hospital of the University of Pennsylvania nearly all the 32 patients with malignancies were symptomatic whereas in the 34 patients with benign lesions the condition was discovered as an incidental finding in about half of the patients. Weight loss, palpable mass or anemia usually indicated malignancy. Small bowel radiography was the most useful diagnostic aid in the present series. While the etiology of these lesions is unknown, villous adenomas probably bear a relationship to carcinoma. The association between chronic regional enteritis and small bowel tumors is unestablished but suggestive. An analysis of reported series reveals a disproportionate incidence of additional primary tumors in patients with small bowel neoplasms. Surgical extirpation is indicated for curative treatment. In the present series, resection in hope of cure was carried out in 25 of 32 malignant tumors resulting in eight five-year survivals. One of these latter lived nine years with disseminated malignant carcinoid reflecting the occasional indolent course of this tumor.


Primary carcinoma of the gallbladder.

Primary carcinoma of the gallbladder. One-hundred-and-seventeen patients with histologically proven carcinoma of the gallbladder are reviewed. The majority of the patients presented with advanced disease with extension and metastasis to the liver and to lymph nodes along the common bile duct. Four patients had localized disease recognized at the time of operation; two were treated with cholecystectomy and two with cholecystectomy and hepatic resection. There were no five-year survivals among these patients. Fourteen patients had clinically inapparent carcinoma at the time of cholecystectomy; the diagnosis being established postoperatively by histologic examination of the excised gallbladder. There were two five-year survivors in this group of patients. Both survivors had early papillary carcinoma confined to the gallbladder wall. The remaining patients with inapparent carcinoma died within three years of the time of operation with recurrent carcinoma. The present report and review of the recent literature emphasizes the poor prognosis associated with carcinoma of the gallbladder. Even with apparently localized lesions, the survival rate is extremely poor. Extended resection, while not of proven value, may improve the survival rate.


Five to twenty year followup after surgery for chronic pancreatitis in 148 patients. One-hundred and forty eight patients operated upon for chronic pancreatitis were reviewed retrospectively in 5-20 year followup. Treatment was by drainage of the duct of Wirsung to adefunctionalized jejunal loop, distal pancreatectomy, pancreato-duodenectomy, splanchnicectomy with an operative mortality of 5%. Influence of clinical and anatomical data upon long term survival and symptomatic results was studied. Among Wirsungo-jejunostomy, distal or cephalic pancreatic resections, survival rates were highest with drainage of the duct of Wirsung and lowest with the pancreatoduodenectomy. Retrospectively, post-operative alcoholism appeared as the alone factor affecting long-term survival. Pancreatic insufficiency and liver cirrhosis were main causes of death. Among the survivors, the percentage of good symptomatic results ranged from (1/3) with splanchnicectomy to 6 of 8 after duodeno-pancreatic resection. Alcohol abstinence affected sypmptomatic results but at a lesser degree than for survival. It was observed that when left pancreatectomy was performed, drainage of the remaining duct of Wirsung into the jejunum significantly improved the good results from 40% to 75%. In the group of wirsungo-jejunostomies without pancreatic resection, it was found that pancreatic calcifications and a large diameter of the duct of Wirsung at the time of operation were favorable prognostic factors.


Gardner's syndrome: report of a family.

Gardner's syndrome: report of a family. Two cases of Gardner's syndrome in one family are presented. The father presented all three stigmas of the syndrome, while in the daughter no osseous manifestations were found. In the first patient, the diagnosis was made only after the second abdominal operation, when a mesenteric fibrous mass was seen. In the second case, the intestinal polyposis was clinically suspected, considering the hereditary aspects of this syndrome, and the episode of bloody diarrhea presented by this patient. Both patients were treated by subtotal colectomy with ileo-rectal anastomosis. Both of them presented fibrous tumors after the abdominal operation (the father after six years and the daughter after one year). The authors stress the importance of postoperative followup for the detection of fibrous masses that may appear due to the surgical stimulus. The literature on Gardner's syndrome is reviewed and summarized.


Relationship of plasma aldosterone concentration to electrolytes and acid-base balance in blood after open cardiac surgery. Plasma aldosterone concentration was measured in 11 cardiac patients after open cardiac surgery, by the radioimmunoassay method, and the relationship of it to electrolytes and acid-base balance of blood was analyzed. Plasma aldosterone concentration was markedly elevated in patients with low cardiac output, who required postoperative drip infusion of Isoproterenol, and in addition, both remarkable metabolic alkalosis and increase of potassium excretion in urine were confirmed in these patients. Plasma aldosterone concentration correlated significantly with potassium excretion in urine and was inversely related with potassium balance. However, plasma potassium concentration or arterial pH had no correlation to it. Approximately an inverse correlation was found between the logarithm of the sodium/potassium ratio in urine and plasma aldosterone concentration. These data indicate that aldosterone is an important factor which produces potassium depletion after open cardiac surgery.


The left shifted oxyhemoglobin curve in sepsis: a preventable defect. Nine patients with severe sepsis were studied to determine causes for any alterations in oxygen dissociation. Seven of the patients had oxyhemoglobin curves shifted to the left of expected and diminished DPG levels. These deficiences were not corrected in one case. The other eight patients survived or expired with normal to elevated P(50T) and DPG levels. In this study, three factors occurring either individually, in concordance, or in sequence were present when P(50T) was decreased. Correction of these deficiencies lead to normalization and, in one case, exceedingly high P(50T) and DPG levels. Where hypophosphatemia, acidosis, and transfusion of DPG deficient blood were avoided, no such change occurred. Hypophosphatemia is a common occurrence in the seriously ill patient whether or not hyperalimentation is used and may occur in spite of phosphate supplementation. Blood transfusions with CPD as the preservative are effective in reducing the severity of this disorder by the addition of an inorganic phosphate load. Septic shock itself had no untoward effect on oxygen dissociation. This held true even in the terminal stages of the disease process.


Mechanism responsible for the cardiovascular depressant. Effect of protamine sulfate. The mechanism of protamine-induced hypotension and bradycardia was investigated in anesthetized, heparinized dogs. Several groups of animals with intact circulation were studied for their responses to protamine under control conditions and following the administration of various pharmacological agents. The parameters observed include femoral arterial pressure (FAP), central venous pressure (CVP), left ventricular pressure (LVP) and its rate of rise (dp/dt), left ventricular contractile element velocity of shortening (Vce), maximal Vce (V max) and cardiac output (CO). Various groups were studied under the following pharmacological conditions: autonomic cholinergic blockade by atropine; alpha and beta adrenergic receptor blockade using phenoxybenzamine and propranolol respectively; ganglionic and adrenal medullary block using hexamethonium, and depletion of endogenous histamine by means of compound 48/80. Another group was placed on total cardiopulmonary bypass thus isolating the heart from the peripheral circulation. The effect of protamine on the vascular tree alone was then observed by monitoring FAP before and after protamine administration. The findings indicate that the cardiovascular effects of protamine are produced by a direct effect on the myocardium and vascular tree.


Letter: "Prophylactic" regional lymph node dissection.


Retained biliary calculi: removal by a simple non-operative technique. Ten patients with retained biliary calculi demonstrated by postoperative T-tube cholangiography were managed by a simple nonoperative washout technique. The bile was cultured routinely before each group of washouts, since fever was a common sequel in the presence of infected bile. After a parenteral dose of propantheline bromide, the biliary tree was flushed through the T-tube with 1 litre of normal saline containing 40 ml of lignocaine. Progress was followed by T-tube cholangiography, and the criterion of success was a cholangiogram showing adequate filling of the biliary tree, absence of filling defects, and free flow of contrast medium into the doudenum. The technique was successful in six of the ten patients. There was no mortality and no significant morbidity.


Aspiration of blood and pulmonary host defense mechanisms. The effect of aspiration of blood on pulmonary host defenses was studied in the rat. Sham and experimental rats had 0.2 ml of saline or blood/100 g body weight injected into their tracheas. One or 24 hours after aspiration rats were challenged with aerosolized, radiolabeled ((32)P), S. aureus. Fourteen hours after bacterial challenge, lungs were removed and intrapulmonary bacterial inactivation was quantified. Significant impairment of bacterial inactivation occurred at both 15 and 38 hours after aspiration of blood, but not after saline. The pulmonary consolidation after aspiration of blood was focal in nature. The lung weight increased but fractional water content decreased. Arterial pH, pCO(2), or pO(2) were unaffected by aspiration of blood. The number and viability of macrophages recovered by lavage were similar in control, sham and experimental groups. If similar impairment in pulmonary host defenses occurred in man following aspiration of blood, the patient with aspiration of blood would have an increased susceptibility to bacterial infection.


Letter: Pathophysiological changes following ischemia of the spleen.


Complete sciatic nerve laceration in a closed femoral shaft fracture.


Intermittent claudication in young athletes: Popliteal artery entrapment syndrome.


Survival following proximal superior mesenteric artery occlusion from trauma.


Editorial note on paper 'serology and genetics of the A1 high H subgroup' by M-alti Sathe and H.M. Bhatia.


In vivo effects of pancreatic elastase. I. Studies on the serum inhibitors.


Differences between mental disorders of French Canadians and British Canadians.


Some factors influencing absorption rates of the digestion products of protein and carbohydrate from the proximal jejunum of man and their possible nutritional implications.


Ultrastructural changes in muscle in spinal muscular atrophy. Werding-Hoffmann's disease.


Biochemical and cytochemical studies of acid and alkaline phosphatases in synovial fluid.


Cervico-dorsal sympathectomy for Raynaud's syndrome.


The eyes' dual function. I.

The eyes' dual function. I.


Improvement of pancreatic imaging.

Improvement of pancreatic imaging.


Atraumatic removal of common duct stones.


Tricuspid atresia with dextroversion. A not very rare combination.


What is rational treatment for carcinoma of the esophagus and cardia?


Pulseless disease with occlusive abdominal aortitis and hypertension. Report of two cases.


The effectiveness and complications of abortion by dilatation and vacuum aspiration versus dilatation and rigid metal curettage.


Letter: Arias-Stella phenomenon.

Letter: Arias-Stella phenomenon.


Editorial: Whither radiology?

Editorial: Whither radiology?


Proceedings: Measles and its complications. A radiological survey.


Use of breath analysis to monitor trichloroethylene exposures.


Mercury in man.

Mercury in man.


Priorities in preventive medicine. Where are the greatest yields?


Letter: More on death comes to dinner.

Letter: More on death comes to dinner.


Proceedings: Primary repair of ventricular septal defect in infancy.


Echocardiography of the aortic valve. I. Studies of normal aortic valve, aortic stenosis, aortic regurgitation, and mixed aortic valve disease.


Proceedings: Value of isometric exercise in assessment of left ventricular function.


Effect of marihuana on the psychological refractory period.


The levels of galactosyltransferase activity in sera from normal children and patients with cystic fibrosis.


Prostaglandins. VI. 9-Desoxy-delta-9(10)-prostatrienoic acids.


The pattern of rape in Singapore.

The pattern of rape in Singapore.


Fresh fractures of the shaft of the humerus--conservative or operative treatment?


Concept of key pulse rate in coronary rehabilitation.


Two types of problem drinkers: both can be managed.


Enlarging skull fractures of childhood.

Enlarging skull fractures of childhood.


Biochemical studies on the shell gland of Japanese quail, Coturnix coturnix japonica. 2. Allosteric two components and their catalytic properties of pyruvate kinase in the shell gland.


Hexachlorophene-pHisohex toxicity in pups.


Dissociation of human albumin dimer by heating.


Isolation and characterization of NRCS-15, a new iron-containing antibiotic.


Primary malignancies of the small bowel: a report of 96 cases and review of the literature. The clinical records and histologic sections of 96 cases of primary small bowel malignancies (excluding lymphomas and periamullary lesions) were reviewed. The location, clinical presentation, pathologic findings, treatment and outcome are compared to the collected published experience, approximately 2400 cases. There were 48 adenocarcinomas, 37 carcinoids, and 11 leiomyosarcomas. Fifty-one men and 45 women ranged from 31 to 83 years old. Eighty-four caused symptoms leading to operative diagnosis; 12 carcinoids were incidental autopsy findings. The most common presentation was pain (33%) followed by weight loss (23%) obstruction (16%), hemorrhage (15%), jaundice (5%), intussusception (3%) and perforation (3%). Masses were felt in 30% of the cases, but were usually dilated bowel or intussusception rather than the tumor per se. Curative resection was attempted in 80 of 84 operatively diagnosed tumors. The 80% mortality among patients followed 5 years is attributed to the late appearance of symptoms and anatomic obstacles to a truly radical operation.


Metabolic products of microorganisms 123. Thraustomycin, a new antifungal nucleoside antibiotic from Streptomyces exfoliatus.


Letter: Minosaminomycin, a new antibiotic containing myo-inosamine.


Letter: Isolation and identification of picronolide, methynolide and neomethynolide produced by Streptomyces venezuelae MCRL-0376.


An in vivo comparison of cefoxitin, a semi-synthetic cephamycin, with cephalothin.


Letter: The abolute structure of oryzoxymycin.


Letter: Roseoflavin, a new antimicrobial pigment from Streptomyces.


Letter: Syntheses of isoseryl derivatives of kanamycins and their antibacterial activities.


Violence and behavior: a symposium on the origins of man's inhumanity to man.


The inheritance of shovel shape in maxillary central incisors.


The British dental arch.

The British dental arch.


Child growth and adult physique in Brazillan Xingu Indians.


Some anthropometric studies of the femur of the male West Malaysian Chinese.


Trypanosoma simiae at the Kenya coast. A correlation between virulence and the transmitting species of Glossina.


The effects of injecting anti-erythrocyte serum into calves infected with Anaplasma marginale.


An epidemiological investigation into Schistosoma mansomi transmission in Mwanza, Tanzania.


Fatal strongyloidiasis in Uganda.

Fatal strongyloidiasis in Uganda.


The morphology and fine structure of the midgut and peritrophic membrane fo the adult female, Phlebotomus longipes Parrot and Martin (Diptera: Psychodidae).


Sulphonamides for the experimental control of the poultry red mite Dermanyssus gallinae (De Geer, 1778).


Masking releease for speech in subjects with temporal lobe resections.


The lightning-damaged ear.

The lightning-damaged ear.


Ataxia, vertigo, and hearing loss. A result of rupture of inner ear window.


Vascular complications of head and neck surgery.


Labyrinithine fistula complicating chronic suppurative otitis media.


Ototoxicity of ethacrynic acid in the anuric guinea pig.


Complications of tympanostomy tubes.

Complications of tympanostomy tubes.


Pneumocele of the maxillary sinus.

Pneumocele of the maxillary sinus.


Brown tumor of the maxilla in secondary hyperparathyroidism.


Muscular lift in cervical rhytidoplasty.


Planning an augmentation mammaplasty.

Planning an augmentation mammaplasty.


Simplifying the Le Fort I type of maxillary osteotomy.


Intradiploic cranial screws and acrylic framework for reduction and external fixation of complex facial fractures.


The preoperative and postoperative consideration of natural facial asymmetry.


Letter: On lid loading in the management of lagophthalmos.


A new fingertip-controlled bipolar forceps for electrocoagulation.


Destructive arthropathy in chondrocalcinosis articularis.


Deforming arthropathy in systemic lupus erthematosus.


Comparison of ultrasound and positive contrast arthrography in the diagnosis of popliteal and calf swellings.


Cytology of rheumatoid synovial cells in culture. I. Composition and sequence of cell populations in cultures of rheumatoid synovial fluid.


Cytology of rheumatoid synovial cells in culture. II. Association of polykarocytes with rheumatoid and other forms of arthritis.


Effect of cell-bound hyaluronic acid on infectivity of Newcastle disease virus for human synovial cells in vitro.


Effect of oral fructose on urate production.


Health costs associated with the mining, transport and combustion of coal in the steam-electric industry.


Successful construction of chimaeric rabbit.


Secretion-dependent uptake of extracellular fluid by the rat neurohypophysis.


Aerosol particles on tobacco trichomes.

Aerosol particles on tobacco trichomes.


Chemical and biological degradation of waste plastics.


Haidinger's brushes and predominant orientation of collagen in corneal stroma.


The apparent heaviness of colours.

The apparent heaviness of colours.


Fluidisation as a feeding mechanism in beach flies.


The structure of the oxidized form of clostridial flavodoxin at 1.9-A resolution.


The amino acid sequence of the Clostridium MP flavodoxin.


Correction of the amino acid sequence of Peptostreptococcus elsdenii flavodoxin.


A point mutation increasing the stability of human phosphoglucose isomerase.


Gel chromatographic analysis of nascent globin chains. Evidence of nonuniform size distribution.


Metal substitutions and inhibition of thermolysin: spectra of the cobalt enzyme.


A unique histidine-rich polypeptide from the malaria parasite, Plasmodium lophurae.


Mutated luciferases with altered bioluminescence emission spectra.


Early mobilization after myocardial infarction. A controlled study.


Temporal sequence of dynamic contractile characteristics in ischemic and nonischemic myocardium after acute coronary ligation.


Limitations of myocardial revascularization in restoration of regional contraction abnormalities produced by coronary occlusion.


Effect of procainamide and lidocaine on ventricular automaticity and reentry during acute coronary occlusion.


Measurement of left heart ejection fraction and end-diastolic volume by a computerized, scintigraphic technique using a wedged pulmonary arterial catheter.


Hereditary defects of the conotruncal septum in Keeshond dogs: pathologic and genetic studies.


Common ventricle with acquired subaortic obstruction.


Control of tachyarrhythmias associated with Wolff-Parkinson-White syndrome by amiodarone hydrochloride.


Single left pulmonary vein with normal pulmonary venous drainage: a roentgenographic curiosity.


Juxtaposition of atrial appendages: angiocardiographic observations.


Right aortic arch with ruptured aneurysm of anomalous left subclavian artery.


Acupuncture anesthesia for open heart surgery. A case report.


Editorial: Acupuncture anesthesia for open heart surgery.


Effect of reserpine on serum gastrin concentration and on mucosal amines and amino acid decarboxylase activities in rat stomach.


Relative toxicity of methotrexate in several tissues of mice bearing Lewis lung carcinoma.


Effects of 6-hydroxydopamine on cardiovascular responses in adrenal denervated dogs.


Selective suppression of neural excitation by tetrodotoxin injected into the canine atrioventricular node artery.


Specificity of blockade of the nicotine-induced release of 3H-norepinephrine from adrenergic neurons of the guinea-pig heart by various pharmacological agents.


Noncholinergic mechanism of action of cholinergic drugs on squid axon membranes.


Effects of amphetamines on regional tryptophan hydroxylase activity and synaptosomal conversion of tryptophan to 5-hydroxytryptamine in rat brain.


Comparative effects of dl-p-methoxyamphetamine and d-amphetamine on catecholamine release and reuptake in vitro.


The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines.


The effects of 3,4-dimethoxyphenylethylamine in rats trained with mescaline as a discriminative stimulus.


Raynaud's disorders revisited.

Raynaud's disorders revisited.


Psychologic problems in anesthesia.

Psychologic problems in anesthesia.


Current management of acute injuries of the skull and brain.


Flexible fiberoptic bronchoscopy.

Flexible fiberoptic bronchoscopy.


Trimethoprim-sulfamethoxazole: antimicrobial synergism.


Congenital renal arterio-venous fistula.


Hospital admissions due to adverse drug reactions. A report from the Boston Collaborative Drug Surveillance Program.


Biochemical precursors of atherosclerosis. Studies in apparently healthy men in a general population, Tecumseh, Mich.


Life support stations.

Life support stations.


Posterior left ventricular preexcitation. Report of a case.


Vena caval obstruction: some epidemiological observations in 76 patients.


Continuous wave ultrasound evaluation of brinase treatment of chronic arterial obstruction.


Cardiac lesions in secondary oxalosis.

Cardiac lesions in secondary oxalosis.


Cardiac function in idiopathic edema.

Cardiac function in idiopathic edema.


Multiform accelerated idioventricular rhythm.


Selective coronary angiography with iodamide. A comparison of myocardial toxicity of two contrast media.


Magnitude of metabolic acidosis in primary hyperparathyroidism.


Axillary artery thrombosis due to crutch trauma.


Uricosuric effect of anticholinergic agent in hyperuricemic subjects.


Immunoglobulin and dextran losses during peritoneal dialysis.


Recurrent ascites following peritoneal dialysis. A new syndrome?


Nephrogenic ascites.

Nephrogenic ascites.


Physiologic measurement of intrahepatic shunted blood flow by method of continuous infusion of D-galactose-1-C.


The Philadelphia Pulmonary Neoplasm Research Project. Early roentgenographic appearance of bronchogenic carcinoma.


Methanol intoxication. Comparison of peritoneal dialysis and hemodialysis treatment.


The conservative treatment of lymphedema of the extremities.


Traumatic intrapericardial hematoma: an unusual cause of mediastinal widening.


Systemic lupus erythematosus resembling malignant atrophic papulosis.


Hereditary hemorrhagic telangiectasia and factor 8 deficiency.


Nephrotic syndrome following topically applied sulfadiazine silver therapy.


Factitial hypoglycemia. Three cases diagnosed on the basis of insulin antibodies.


Congenital dyserythropoietic anemia type I. Report of a case with increased erythrocyte agglutinability by anti-i serum.


Hemolytic anemia and somatic cell dysfunction in severe hypophosphatemia.


Hypersomatotropism and acanthosis nigricans in two brothers.


Leprosy in Vietnam veterans.

Leprosy in Vietnam veterans.


Colitis following oral lincomycin therapy.


Faculty scholarship. Those hallowed halls of vested interest.


Mitochondrial changes in dog myocardium induced by neutral lactate in vitro.


Penetration of the respiratory epithelium of guinea pigs following exposure to cigarette smoke.


Subacute sclerosing panencephalitis virus. Observations on a neuroadapted and non-neuroadapted strain in organotypic central nervous system cultures.


Peroxidase activity in the developing rat submandibular gland.


Primary adult lactose intolerance in the Kivu Lake area: Rwanda and the Bushi.


Liver function and histology in asymptomatic Chinese military personnel with hepatitis B antigenemia.


The effect of bicarbonate and acidification on water and electrolyte absorption by the intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats.


Mitochondrial antibodies in extrahepatic biliary obstruction.


Changes in plasma free fatty acid concentration following oral lactose tolerance tests as a test for lactose absorption in infants and children.


Gastric abscess--a complication of pancreatitis.


Evaluation of body magnesium stores.

Evaluation of body magnesium stores.


Metastatic bronchogenic carcinoma seen as a gastric ulcer.


Editorial: Does countercurrent exchange influence small-bowel function?


Soluble fibrin complexes in experimental thrombotic states.


Cirrhosis and death after jejunoileal shunt for obesity.


Hydrogen (H2) catabolism in the colon of the rat.


Effects on hemoglobin oxygen affinity of smoking in residents of intermediate altitude.


Pulmonary oxygen toxicity in opossum pouch young, weanlings, and mothers: preliminary observations.


Erythrocyte O2 affinity: influence of cell density and in vitro changes in hemoglobin concentration.


Airway responses to histamine, acetylcholine, and antigen in sensitized guinea pigs.


A simple method for calculating Vmax.

A simple method for calculating Vmax.


Inhibition of human lymphocyte blast transformation by streptolysin O.


Comparison of factors regulating red cell 2,3-diphosphoglycerate (2,3-DPG) in acute and chronic hypoxemia.


Comparison of capillary and venous blood sampling for quantitation of plasma cholesterol.


Automated radiometric assays of enzymatic and nonenzymatic oxidation of DOPA in vitro.


Commentary: The communication gap: clinical pharmacology and the public.


Studies on digitalis. I. Renal excretion of digitoxin and its cardioactive metabolites.


Studies on digitalis. II. The influence of impaired renal function on the renal excretion of digitoxin and its cardioactive metabolites.


Morphine metabolism in man.

Morphine metabolism in man.


Effect of food on nitrofurantoin absorption.


Clinical biostatistics. 28. The biostatistical problems of pharmaceutical surveillance.


Platelet preservation--what temperature? A rationale for strategy.


Editorial: A 'program' for the chronically ill.


Rejuvenation of human red blood cells during liquid storage.


High risk subjects and the cost of large field trials.


Washing of red blood cells previously frozen in liquid nitrogen. Experience with the Elutramatic Ultra-Flo system.


Smoking and mortality among U.S. veterans.


Increased granulocyte collection with the blood cell separator and the addition of etiocholanolone and hydroxyethyl starch.


Buerger's disease in Indonesia: Clinical course and prognostic factors.


Physical activity at work and the incidence of myocardial infarction, angina pectoris and death due to ischemic heart disease. An epidemiological study in Israeli collective settlements (Kibbutzim).


Salt taste in patients with essential hypertension and with hypertension due to primary hyperaldosteronism.


Effects of in vitro storage on red blood cell agglutinogens.


Electrophysiological studies of olfactory projection to the mesencephalic reticular formation.


Modulation of recurrent inhibition in cat association cortex by reticulocortical arousal.


Intensive multiunit plateletpheresis of normal donors.


Hippocampal units during orienting and arousal in rabbits.


Proprioceptive influences on inferior olivary neurons during phasic reflex movement in the cat.


Morphological changes in pyramidal cells of mammalian neocortex associated with increased use.


Kidd blood-group antigens of leukocytes and platelets.


Hemoglobin catabolism following a hemolytic transfusion reaction in a patient with sickle cell anemia.


Transient alteration of the blood-brain barrier: effect of hypertonic solutions administered via carotid artery injection.


Reticular modulation of evoked potentials at the cortex and lateral geniculate nucleus of the unanesthetized squirrel monkey.


Protein synthesis in neurons and glial cells by extrahepatic cholestasis in rats.


Acetylcholine contractures in murine dystrophy and the neurogenic hypothesis.


Analysis of Q-banding patterns in human cell lines.


Cancer of the prostate among men with benign prostatic hyperplasia.


Physical and demographic features of men before developing cancer of the prostate.


Multiple primary neoplasms in blacks compared to whites. 3. Initial cancers of the female breast and uterus.


A cancer treatment data base system: a feasibility study.


Reactions between activated benzo(a)pyrene and nucleophilic compounds, with possible implications on the mechanism of tumor initiation.


Effect of beta-irradiation on 3-methylcholanthrene induction of brain tumors in mice.


Host responses in Friend virus-induced leukemia.


Escape of small numbers of allogeneic lymphoma cells from immune surveillance.


Stem cell growth and production of colony-stimulating factor in Rauscher virus-infected CBA-J mice.


Diethylnitrosamine-induced chromosome changes in rat liver cells.


Tumor control and regrowth probability after a single radiation of experimental animal tumors.


Hyperplastic nodules and adenomas of exocrine pancreas in azaserine-treated rats.


Letter: Hormonal carcinogens.

Letter: Hormonal carcinogens.


Clinical comparison of tyropanoate sodium, ipodate sodium, and iopanoic acid.


Clinical trial of bilopaque (tyropanoate sodium) oral cholecystography. Evaluation of time for the optimal and peak opacification of the gallbladder.


Time of optimal gallbladder opacification with bilopaque (tyropanoate sodium).


Angiographic diagnosis of mesenteric arterial vasoconstriction.


Long-term results in 100 consecutive patients treated by transluminal angioplasty.


Studies of tantalum dust in the lungs.

Studies of tantalum dust in the lungs.


Extrapleural costal fat.

Extrapleural costal fat.


Pulmonary cryptococcosis.

Pulmonary cryptococcosis.


Pulmonary edema induced by oral methadone.


Cecal herniation through the foramen of Winslow.


Ankylosing spondylitis and regional enteritis.


Typhoid fever.

Typhoid fever.


Temporomandibular joint involvement in ankylosing spondylitis. Comparison with rheumatoid arthritis and psoriasis.


Angiography of cervical cord injuries.

Angiography of cervical cord injuries.


The lack of renografin-76 toxicity in acute severe spinal cord injury.


Diastematomyelia in children. Radiographic study of 34 cases.


Subdural pantopaque: a radiologist's dilemma.


Augmented splenic uptake of 99mTc-sulfur colloid in patients with malignant melanoma.


The scintigraphic features of the occipital sinus.


Nonspecificity of gallium accumulation: gallium-67 concentration in cerebral infarction.


Cardiac shunt assessment in children with macroaggregated albumin technetium-99m.


Concentration of 99mTc diphosphonate in breast tissue.


Gasless abdomen in neonates with orotracheal tubes.


Brain tumors in children: analysis of 136 cases.


The autosomal recessive form of spondylocostal dysostosis.


Radiation and small bowel complications in cervical carcinoma therapy.


Carcinoma of the kidney in children. Results of an interdisciplinary approach to management.


Calcification in mediastinal lymph nodes after radiation therapy of Hodgkin's disease.


Radiation levels of macroradiography. Radiation exposure and image quality.


Radiation dose to eye lens and gonads during transfemoral cerebral angiography.


Radiotherapy of a mouse mammary carcinoma following treatment with 5-iodo-2'-deoxyuridine.


Studies in adherence of contrast media to mucosal surfaces. Methods and preliminary investigations.


Ultrasonically guided percutaneous aspiration biopsy of the pancreas.


Infusion angiography using xeroradiography.


Plasma levels and tricyclic antidepressants.


Concentration-effect relationships with major and minor tranquilizers.


Application of blood level data to clinical trials.


Monitoring of plasma levels of a hypolipemic agent.


Pharmacodynamic and pharmacokinetic measurements in cardiovascular-renal drugs.


Influence of serum digoxin concentration measurements on frequency of digitoxicity.


Drug dosage in patients with renal disease.


Estrogen-induced hypernephroma.

Estrogen-induced hypernephroma.


Normal renin secretion in hypertensive patients with primarily unilateral chronic hydronephrosis.


Vena cava resection for renal cell carcinoma.


Visceral collateral arterial circulation: another cause of ureteral notching.


Tomography of the ureter.

Tomography of the ureter.


Recent development for pyeloureteroscopy: guide tube method for its introduction into the ureter.


Reconstruction of the upper ureter with colon.


Experience with transureteroureterostomy in the paraplegic patient with irreversible vesicoureteral reflux.


Conservative surgical management of transitional cell carcinoma of the upper urinary tract.


Metastatic cancer to the ureter: a review of the literature and case presentations.


Perforation of a neo-rectal bladder by Ascaris lumbricoides: a case report.


Spontaneous vesicocutaneous fistula caused by actinomycosis: case report.


Management of vesicovaginal fistulas with peritoneal flap interposition.


Spermatocytic seminoma.

Spermatocytic seminoma.


Thrombocytopenia with external genital gangrene.


Untwisting in delayed treatment of torsion of the spermatic cord.


Varicocele in infertility: incidence and results of surgical therapy.


Vasectomy--discomfort and complications in 1,100 patients studied: the role of steroids in the prevention of swelling and discomfort.


Transurethral prostatic resection in patients with myasthenia gravis.


A second look operation after unsuccessful Kaufman 2 repair for post-prostatectomy urinary incontinence.


Prognostic usefulness of serum acid phosphatase levels in carcinoma of the prostate.


Significance of anaerobic bacteria isolated from the urinary tract. I. Clinical studies.


The role of the radioisotope renogram in the diagnosis and evaluation of radiation nephritis.


The non-operative re-establishment of a broken loop nephrostomy.


Loop cutaneous ureterostomy and cutaneous pyelostomy: one-stage reconstruction.


Electromyographic study of hop dislocation in cerebral palsy.


Low cost electronic thermometer.

Low cost electronic thermometer.


Prediction of maximal oxygen intake from Astrand-Rhyming test, 12-minute run, and anthropometric variables using stepwise multiple regression.


Gluconeogenesis in epinephrine-induced hyperglycemia.


Responses of the canine heart to stimulation of the first five ventral thoracic roots.


Effect of calcium infusion on renal tubular reabsorption in the dog.


Glucagon stimulation of gluconeogenesis from alanine in the intact dog.


Brain manganese in the developing chick.


Active and passive behavior of the canine vena cava in vivo.


Oxygen sensitivity of vascular smooth muscle. II. In vivo studies.


Lactate metabolism following severe hemorrhage in the conscious dog.


Glucose metabolism following severe hemorrhage in the conscious dog.


Blood lactate from exercising extremities before and after arm or leg training.


Behavioral and neurochemical alterations induced by hypoxia in rats.


Acute effects of insulin on carbohydrate metabolism in rat liver slices: independence from glucagon.


Food intake in hypothalamic obesity.

Food intake in hypothalamic obesity.


Basis for posttetanic potentiation at the mammalian neuromuscular junction.


Effects of glucose feeding on insulin and glucagon secretion and hepatic gluconeogenesis in the rat.


Adrenomedullary pressor responses during posterior hypothalamic stimulation.


Autoregulation of filtration rate in the absence of macula densa-glomerulus feedback.


Evidence for derivative control in the rat pituitary-adrenal system.


Effects of gastric arterial and venous pressures on gastric secretion in the dog.


Stimulation of food intake in ruminants by 2-deoxy-D-glucose and insulin.


Individual nephron function and renal oxygen consumption in the rat.


Evidence against the presence of ventricular chemoreceptors activated by hypoxia and hypercapnia.


Canine intestinal secretion during and after rapid distention of the small bowel.


Effect of theophylline of hepatic excretory function.


Dynamics of glucose autoregulation in the isolated, blood-perfused canine liver.


A comparison of temperature regulation in hibernating rodents.


Spatial distribution of pulmonary blood flow in dogs in left decubitus position.


Tunable laser fluorescence method for product state analysis.


Urban growth and decline: San Jose and St. Louis in the 1960's. The population changes in San Jose and St. Louis between 1960 and 1970 exemplify the two broad trends-urban formation followed by metropolitan dispersal-that have shaped 20th-century urbanization in this country. The fact that these developmental trends were expressed through demographic processes found to be common to both cities, despite their contrasting recent experiences, suggests that generalizations can be made about the complex forces underlying urbanization. The formation of metropolitan San Jose's population parallels the traditional process whereby a region's growth comes to be focused, through migration, on a few urban centers. The modern variant is not characterized by a rural-to-urban shift, however, but by migration flows among urban areas, and particularly to a few most-favored areas, such as San Jose. Migratory growth has left a powerful demographic legacy in San Jose. This legacy is also instructive for studying the migratory formation of any new city's population. Its demographic character determines its demographic destiny, whose likely variations we can now perceive with some clarity. San Jose's population is both youthful and chronically migratory. The presence of many prospective parents and relatively few elderly persons lays a broad foundation for the population's continued growth through natural increase, despite the national downturn in fertility (14). Even without further net in-migration, the population of new cities like San Jose would continue to grow at an above-average rate. The hypermobility of San Jose's population (that is, its propensity for further migration) also has an important bearing on the future. With about 21 migrants entering and 17 departing each year per hundred residents, San Jose's rapid migratory growth rests (as it would in other new cities) on a precarious arithmetic balance. A significant dip in local employment growth could easily reduce net migration to a small fraction of its present high level. Even a slight decline would result in the inflow's no longer exceeding the high volume of outflow. Demographic analysis alone cannot foresee such an employment downturn, but if it happened, the migratory downturn probably would be swift. Hypermobility also works the other way; and given San Jose's focal position in California's expanding metropolitan structure (with its virtually endless supply of migratory growth), net migration could resume with equal swiftness. The outward dispersal of population from central cities that has occurred in St. Louis has been accelerating in other cities as well, and will remain a prominent feature of U.S. urban growth. It may seem paradoxical that in a period noted for something called "urban growth" there are so many declining central cities, but that is merely one indication that the "central city" no longer is the real city, except in name. Real city or not, the central city can expect to come into political conflict with other jurisdictions created in the process of dispersion. In cities like St. Louis, where population is dispersing but old political boundaries are fixed, the problems of the central city are separated from the resources in the suburbs. Transitional problems associated with persistent and severe outmigration also arise: accumulation of disadvantaged citizens, declining demand for city housing, and a diminished replacement capacity in the population. Carried far enough, the last of these problems results in natural decrease, and thereafter the population's decline acquires its own dynamic. As noted earlier, the white population in St. Louis has reached this point: The number of persons dying now exceeds the number being born. For two reasons, this natural decrease can do little other than intensify. First, a substantial proportion of whites are either entering or already within the high-mortality age brackets. The white population's crude death rate therefore will continue to rise. Second, prospective parents are becoming scarce among St. Louis's whites, and the national evidence that parents in general will choose to have smaller families continues to mount. The white population's crude birth rate is therefore likely to fall, barring a dramatic increase in fertility or a strong and sustained inflow of childbearing families. Nor is St. Louis's black population likely to grow substantially. It is expanding steadily through natural increase, but black migration out of the city is more than enough to cancel that increase.


Complement-dependent stimulation of prostaglandin synthesis and bone resorption. Complement-sufficient heterologous serum induced prostaglandin synthesis and resultant resorption in cultures of fetal rat long bones. Bone resorption was enhanced with unheated normal rabbit serum as compared to heated serum or serum from rabbits lacking the sixth component of complement (C6). Addition of functionally purified C6 restored resorptive activity in C6-deficient serum. Concentrations of prostaglandin E were increased in the culture media of bones incubated with complement-sufficient serum. The resorptive effects of active serum as well as the appearance of prostaglandin E in the media were inhibited by indomethacin.


Selective alkylation: a biomimetic reaction of the antileukemic triptolides? The potent antileukemic plant principles triptolide and tripdiolide contain a characteristic hydrogen-bonded 9,11-epoxy-14beta-hydroxy system. They alkylate propanethiol in a process which involves opening of the epoxide function with neighboring hydroxyl assistance. The reaction may mimic the inhibition of tumor growth via selective alkylation of the thiol groups of key enzymes concerned with groth regulation.


Aglomerularism in Antarctic fish.

Aglomerularism in Antarctic fish. Urine formation in antarctic bony fish does not involve glomerular filtration. Evidence for aglomerularism came from both direct observation of kidney serial sections by light microscopy and the low concentrations of inulin labeled with carbon-14 that were excreted into the urine when this renal clearance tracer was injected into the bloodstream via a cannula implanted in the caudal vein. Aglomerularism most likely prevents urinary loss of glycoproteins with biological antifreeze properties.


Olfactory learning-set formation in rats. Rats trained on 16 two-odor discrimination problems showed rapid acquisition of a learning set and one-trial learning by the end of the problem series. Learning to sample odor cues before responding and adoption of a "win-stay, lose-shift" strategy probably accounts for the virtually errorless learning. Learning-set performance of rats trained with odor stimulus comparable to that reported for primates trained on visual cues.


On the mechanisms responsible for selection of hepatic veins as target for thrombosis following injection of endotoxin in hyperlipemic rats. The feeding of a butter-rich diet, to sensitize rats for studying the phenomenon of hepatic vein thrombosis, is shown to produce severe liver steatosis leading to a sinusoidal barrage and portal hypertension. The portal pressure in these animals was 210 +/- 4 mm of saline, as compared to 113 +/- 3 mm in the normal rat. Blood circulation studies using carbon suspensions revealed production of a vascular stasis in the hepatic veins after 60 to 90 minutes, when endotoxin (Salmonella typhosa, 0.3 mg/kg) is introduced into the blood circulation to initiate hepatic vein thrombosis. Similar results were observed after 15 minutes with ellagic acid (1 mg/kg/min). The stasis was found in connection with an additional intrahepatic resistance to blood flow as evidenced by a rise in portal pressure and by a reduction in liver perfusion in relation with development of systemic hypotension. In contrast with this, endotoxin initiated only slight and transient changes in the normal rat. Thrombosis immediately followed production of stasis in the hepatic vein, whether the phenomenon was initiated by endotoxin or ellagic acid. Furthermore, inhibition of the vascular stasis of alpha-adrenergic blockade (phenoxybenzamine, 3 mg/kg) was accompanied by prevention of hepatic vein thrombosis. It is concluded that stasis in the hepatic veins resulting from a mechanical obstruction of the circulation by steatosis and by an additional reduction in blood flow initiated by endotoxin, is responsible for selection of hepatic veins as targets for thrombosis following injection of endotoxin in hyperlipemic rats.


Activation of Hageman factor and initiation of hepatic vein thrombosis in the hyperlipemic rat. Hepatic vein thrombosis initiated by an intravenous injection of endotoxin (Salmonella typhosa, 0.3 mg/kg) resulted in an incidence of 78% in rats fed a butter-rich diet (group 1). On the other hand, no lesion could be produced in control animals fed corn oil (group 2) or standard chow (group 3). In regard to the respective thrombotic tendencies, the rats fed butter showed higher circulating levels of factor XII (175% vs 140% in group 2 and 100% in group 3) and a far more severe decrease in this factor (41% vs 15% in group 2 and 7% in group 3) and in platelets (48% vs 25% in group 2 and 19% in group 3) 2 hours after the injection of endotoxin. The triggering effect of endotoxin could be reproduced by ellagic acid, a known activator of factor XII. Given by slow infusion (1 mg/kg/min) this chemical induced hepatic vein thrombosis in 52% of the rats fed the butter-rich diet. Furthermore, inhibition of factor XII activation by lysozyme (20 mg/kg/min) completely prevented hepatic vein thrombosis initiated by endotoxin in butter-fed animals. It is concluded that, in addition to the potent hypercoagulability induced by the fat-rich diets, activation of Hageman factor consecutive to endotoxin injection is essential for production of the phenomenon of hepatic vein thrombosis.


The natural history of neuroblastic cells in the fetal adrenal gland. A study was made of neuroblastic nodules of the human adrenal gland in fetal life to determine their embryonic morphology and derivation. One hundred sixty-nine glands from 92 fetuses selected from 106 consecutively submitted fetuses formed the basis of this study. All adrenal glands examined contained neuroblastic nodules. They increased in number and maximum size with increasing age, peaked at 17 to 20 weeks gestational age, and regressed in the oldest fetuses. It is concluded that such neuroblastic nodules are an integral part of the normal morphogenesis of the adrenal gland. Their presence at birth and early infancy may represent a normal variation, and they do not necessarily constitute microscopic incipient malignancy.


Experimental aortic intimal thickening. I. Morphology and source of intimal cells. Repair to injury of the rabbit aorta was studied with special attention to the source of new intimal cells. Two types of injury, suture placement and electrocautery, were used to ascertain whether the type of injury significantly modifies the reparative response of the artery. Cell morphology and DNA synthesis, as determined by autoradiographic localization of tritiated thymidine uptake, were studied sequentially during the course of the repair reaction. Suture injury was the more reliable model for these studies because the magnitude of injury was quite comparable between animals, while with cauterization there was considerable variation in the magnitude of injury. The overall reparative response with the two types of injury was, however, similar. Cell division was first seen in the media adjacent to the injured focus and was followed by migration of medial cells into the intima. In the intima, medial cells continued to divide for a few days and then gradually matured from undifferentiated ovoid cells resembling monocytes to morphologically differentiated smooth muscle cells. Medial cells exhibiting DNA synthesis were both differentiated and undifferentiated smooth muscle cells, supporting previous reports that mature as well as undifferentiated smooth muscle cells are capable of mitosis. However, with injury and repair, the migrating cells appeared to be mainly undifferentiated since there was a predominance of these cells early in the repair reaction in the intima.


Experimental aortic intimal thickening. II. Endothelialization and permeability. Experimental aortic intimal thickening has been induced in rabbits by two types of injury, suture placement and electrocautery. Scanning electron microscopy showed that endothelialization of the suture plaque was completed at about 10 days following injury. New endothelial cells had no particular orientation or were oriented at right angles to the adjacent normal aortic endothelium. Realignment parallel with the aortic axis had occurred by 21 days after induction of the lesion. Orientation patterns of new endothelial cells over irregularly shaped cautery-induced intimal thickening were difficult to ascertain. Aortic permeability studies were accomplished by using the tracers horseradish peroxidase (HRP) and ferritin. Several naturally occurring intimal thickenings in normal aortas had greater permeability for HRP than did adjacent normal intima. An enhanced penetration of both tracers was observed in mature intimal lesions produced by both experimental procedures compared to adjacent morphologically normal aortic intima. HRP molecules entered the thickened aortic intima in increased amounts through interendothelial junctions and by endothelial pinocytotic vesicles; ferritin molecules were seen only in pinocytotic vesicles. Increased penetration of HRP was observed for as long as 27 weeks after injury, while that of ferritin was observed only for 3 weeks. The enhanced permeability of the thickened intima as compared to normal for these two tracers of considerably different sizes strongly suggests an increased permeability of endothelium overlying intimal thickening for naturally circulating macromolecules.


Acute Newcastle viral infection of the upper respiratory tract of the chicken. I. A model for the study of environmental factors on upper respiratory tract infection. Acute Newcastle disease virus infection following intranasal inoculation of chicks with a mesogenic strain of the virus produced a localized infection of the middle turbinate which was histologically demonstrable 18 hours after inoculation. There was destruction of mucous cells of individual acini in the under surface of the middle turbinate, and the infection rapidly spread to ciliated and goblet cells and to neighboring acini. By day 2 there was simultaneous remodeling of the mucosa, continued destruction and inflammatory infiltration and frequent loss of cartilage basophilia. By day 3 polymorphonuclear cells almost disappeared, epithelial mitoses commenced, and lymphocyte infiltration intensified; the plasma cells normally present along the lateral nasal gland ducts were often destroyed, very occasionally the glands themselves were destroyed. By days 5 and 6 inflammation greatly decreased, and by day 8 the mucociliated epithelium was essentially normal. The infection is sequentially comparable to acute mild rhinitis of man.


Pathogenesis of hemorrhage induced by rattlesnake venom. An electron microscopic study. The pathogenesis of hemorrhage induced by rattlesnake (Crotalus atrox) venom was investigated at the electron microscopic level. Swiss-Webster white mice were injected intramuscularly with one-fifth the LD(50) dose of whole venom. Muscle samples were obtained by biopsy 2 minutes, 30 minutes and 3 hours after venom injection. Capillaries in the endomysium were in various stages of degeneration. Endothelial cells of damaged capillaries contained dilatated endoplasmic reticulum and perinuclear space, and, in many cases, swollen cytoplasm. Blebbing of endothelial cytoplasm of swollen and nonswollen cells was observed. These changes were followed by rupture of the plasma membrane which resulted in the subsequent extravasation of blood. Platelet aggregations plugged gaps in vessel walls and often completely occluded the lumina of capillaries. The experimental injection of rattlesnake venom induced hemorrhage by rhexis. The same or a similar pathogenesis is probably responsible for hemorrhage which occurs in actual snakebite cases.


The ultrastructure of the anastomosed vein of experimental arteriovenous fistulae in sheep. The ultrastructural changes in the anastomosed veins of chronic experimental carotid-jugular arteriovenous fistulae in sheep have been contrasted with the changes in a) the veins of sheep subjected to phlebotomy from the contralateral side and b) the veins of sheep without arteriovenous fistulae. The anastomosed veins exhibited a profound phlebosclerosis which was in marked contrast with the mild degree observable in the contralateral veins of the experimental sheep and with the minimal alterations in control animals. There was progressive and extensive loss of elastic tissue, as well as thickening and proliferation of basement membranes, separation of basement membranes from both the endothelium and smooth muscle cells, and the accumulation of much amorphous material in the interstitium. Collagen was relatively sparse. Some endothelial gaps and denudation were observed and associated with the presence of fibrin and red cells in the intima. Muscle cells exhibited necrosis and degeneration with much cell debris and some extracellular lipid. The results indicate that hemodynamic stress is capable of inducing, in the vessel wall, profound cellular and connective tissue changes.


Letter: Practical approach to cost analysis.


Letter: Occupational health case reports.


Polymer-fume fever: not so benign.

Polymer-fume fever: not so benign.


Maximum weights and work loads acceptable to female workers.


Respiratory cancer among chromate workers.


Firefighters' occupational exposure to carbon monoxide.


The development of a cotton dust standard.


Vibration syndrome in lumbermen (working with chain saws).


Community health services: ten factors to consider.


Visual requirements.

Visual requirements.


Myocardial infarction in nine patients with radiologically patent coronary arteries.


Departments of medicine--1973.

Departments of medicine--1973.


Hepatic injury from chronic hypervitaminosis a resulting in portal hypertension and ascites.


Shortage of doctors--high-rise living--unrest in the NIH and threat to private practice.


Doctors in politics: a lesson from Chile.


Editorial: Fugitive coronary occlusion.

Editorial: Fugitive coronary occlusion.


Letter: Lung dysfunction after myocardial infarction.


Letter: Management of pre-eclampsia.

Letter: Management of pre-eclampsia.


Letter: Positive antiglobulin test after BCG immunotherapy.


Letter: Frequency of operations on physicians.


Letter: Correct procedure for CEA assay.


Letter: Proper technic in measurement of blood gases.


Letter: Hodgkin's disease in schoolteachers.


Letter: Biomedical ethics.

Letter: Biomedical ethics.


The effects of frictional stimulation on mouse ear epidermis. II. Histologic appearance and cell counts.


Human fetal hair follicles: the mesenchymal component.


Trichodiscoma. A benign tumor related to haarscheibe (hair disk).


The nature of tribromosalicylanilide photoallergy.


Private practice experience with permanent cardiac pacing.


Mesenteric cysts.

Mesenteric cysts.


Primary malignant melanoma of the esophagus: a case report.


Subdiaphragmatic esophageal perforation from endoscopy: a case report and review of literature.


Salvage of amputated facial tissue.

Salvage of amputated facial tissue.


Spontaneous rupture of accessory spleen.


Superior mesenteric arteriovenous fistula.


Editorial: Too many surgeons:.

Editorial: Too many surgeons:.


Editorial: A computer logic program in the operating room.


Long-term results of hepatic portoenterostomy for biliary atresia: special reference to postoperative portal hypertension.


Attitudes of British graduates on surgical research fellowships in the United States.


Changes and trends in graduate medical education and credentialling.


Thrombosis in the superior mesenteric and portal veins: report of a case treated with thrombectomy.


Effect of aspirin on microaggregate formation in banked blood.


Letter: Is the author the writer: who cares?


Teratomas in infancy and childhood: experience with 81 cases.


Letter: A splendid statement on a taboo subject.


Letter: Myocardial glycogen.

Letter: Myocardial glycogen.


Letter: Anatomic approach to vagotomy.

Letter: Anatomic approach to vagotomy.


Letter: Subclavian steal syndrome.

Letter: Subclavian steal syndrome.


Letter: Painless removal of sutures.

Letter: Painless removal of sutures.


Letter: Value of intraoperative tests in vagotomy.


The treatment of premature labour with intravenously administered salbutamol.


Chronic respiratory disease in an outer suburban industrial area.


Intercostal drain tubes: massive surgical emphysema as a preventable complication.


Intestinal and cutaneous haemangiomatosis.


Oestrogen assays in obstetric practice.

Oestrogen assays in obstetric practice. The use of estrogen assays in monitoring fetoplacental function was discussed.  In early pregnancy estrogen plus chorionic gonadotropin and progesterone or pregnanediol levels give a picture of the hormonal events.  Important reasons for these assays are suspected, threatened, missed, or recurrent abortion, mole pregnancy, error in dates, suspected early pregnancy, ectopic pregnancy, or the presence of an abdominal mass.  Estriol assay is the best test for monitoring fetoplacental function in late pregnancy.  It was found that the perinatal mortality rate was around 9% when estriol values were low compared with 1.8% in the normal estriol group.  Falling estriol levels are a poor prognosis and rising values are a good prognosis.  Cortisone and ampicillin can depress urinary estriol excretion.  Mandelamine destroys estriol during the assay.  Plasma estrogen assays are also available; however, further work is necessary to determine which fraction is most relevant in assessing fetal risk.


Further experience with cryosurgery in treatment of intractable epistaxis.


Analgesic consumption in an antenatal clinic survey.


Round table conference on asthma.

Round table conference on asthma.


Letter: Bullous eruptions.

Letter: Bullous eruptions.


Letter: Failure to keep appointments.

Letter: Failure to keep appointments.


Letter: Treatment of diabetes insipidus.


Letter: Physical signs and diagnosis.

Letter: Physical signs and diagnosis.


Vectorcardiogram of the 'man-frog'.

Vectorcardiogram of the 'man-frog'.


Pathology of Gaucher's disease.

Pathology of Gaucher's disease.


The temporomandibular pain-dysfunction syndrome.


Carcinoid of the rectum. Case report and surgical management.


Alcohol: a cause of diabetes in Rhodesia.


Traumatic intrarenal arteriovenous fistula treated by conservative surgery. Case report and review of the literature.


An anthropologist looks at malaria.

An anthropologist looks at malaria.


Origins of medicine and pharmacy at the Cape of Good Hope.


Right aortic arch and associated anomalies. Report of two cases compared with a case of complete situs inversus.


Acute infantile hemiplegia associated with ipsilateral retinal vascular occlusion.


Changes in secretory cells during early stages of experimental carcinogenesis in the rat submandibular gland.


Incorporation of arginine by soluble extracts of ascites tumor cells and regenerating rat liver.


Methylmercapto-4-acetylaminostilbenes as products of the reaction of n-acetoxy-4-acetylaminostilbene with methionine and as degradation products of liver protein from rats given n-hydroxy-4-acetylaminostilbene.


The effect of 6-mercaptopurine and allopurinol on granulopoiesis.


Cytofluorescence localization of adriamycin and daunorubicin.


Two patterns of neutral steroid conversion in the feces of normal North Americans.


Vascular changes in neuroblastoma of mice following x-irradiation.


A study of respiration and oxidative phosphorylation of mitochondria from regenerating liver of normal and diabetic rats.


A cytological scale for cervical carcinogenesis.


Colon carcinogenesis in germ-free rats with 1,2-dimethylhydrazine and N-methyl-n'-nitro-N-nitrosoguanidine.


The induction of alkaline phosphatase activity in HeLa cells by 5-iodo-2'-deoxyuridine.


Cell kinetics and growth of squamous cell carcinomas in man.


Letter: Role of podophyllotoxin in the bedding and dietary zearalenone on incidence of spontaneous tumors in laboratory animals.


A possible neurophysiological basis for the precedence effect.


Role of auditory cortex in sound localization: a comparative ablation study of hedgehog and bushbaby.


Does tonotopicity subserve the perceived elevation of a sound?


Relations between the psychophysics and the neurophysiology of sound localization.


Evaluation of dehydrated poultry waste as a feed ingredient for poultry.


Animal wastes as substrates for protein production.


Nutritional value of cattle waste for cattle.


Health criteria for processed wastes.

Health criteria for processed wastes.


Obesity: a brief overview with emphasis on exercise.


Effect of exercise on adipose tissue cellularity.


Rat fat cell size and number with exercise training, detraining and weight loss.


Effect of training on adipocyte glucose metabolism and insulin responsiveness.


Impact of Fourier transform techniques on high resolution NMR spectroscopy.


Maintenance of human diploid fibroblasts as arrested populations.


Letter: Interrelationships of ascorbic acid and tryptophan metabolism.


Biochemical and physiological studies of certain ticks (Ixodoidea): specific gravity of hemolymph and coxal and gut fluids of Argas (Persicargas) persicus and Argas (Persicargas) arboreus (Argasidae).


Trypanosoma congolense. II. Histopathologic findings in experimentally infected cattle.


Operative cholangiography in a rural surgical practice.


Dermal ischemia in thermal injury: the importance of venous occlusion.


Are consumer products dangerous?

Are consumer products dangerous?


Gallsonte pancreatitis.

Gallsonte pancreatitis.


Normal growth of ultrastructures in rat left ventricular myocardial cells.


Sodium cyanate induced polyneuropathy in patients with sickle-cell disease.


Localization of the kidney for percutaneous biopsy. A comparative study of methods.


Penicillin-sensitive streptococcal endocarditis. In-vitro and clinical observations on penicillin-streptomycin therapy.


Polymyositis and dermatomyositis: combined methotrexate and corticosteroid therapy.


Sarcoidosis of the pleura.

Sarcoidosis of the pleura.


Necrotizing vasculitis after acute serous otitis media.


The effect of isoniazid on transaminase levels.


Epidermolysis bullosa: gastrointestinal manifestations.


Editorial: Drug costs and drug quality.

Editorial: Drug costs and drug quality.


Erythrocyte fragmentation in defibrination syndromes.


South Africa: two-language medicine.

South Africa: two-language medicine.


Medical consequences of alcoholism.

Medical consequences of alcoholism.


Letter: Theory of adaptive antibody formation and "crib death".


Letter: Spontaneous spinal epidural hematoma in alcoholism.


Letter: What can practitioners do?

Letter: What can practitioners do?


Letter: Support for part-time teaching.

Letter: Support for part-time teaching.


Letter: Chloride: phosphate and hypercalcemia.


Letter: Isoniazid.

Letter: Isoniazid.


Letter: Eikenella corrodens infection.

Letter: Eikenella corrodens infection.


Letter: Dental procedures and bacteremia.


Letter: Leukocyte alkaline phosphatase.

Letter: Leukocyte alkaline phosphatase.


Letter: Pulmonary edema and salicylates.


Editorial: Medical devices, national standards, and the physician.


Protection of the pulmonary microvasculature by fine screen blood filtration.


Ethambutol in pregnancy.

Ethambutol in pregnancy.


Second degree block within the bundle branches.


Graphic techniques in cardiology. Atrial contribution to carotid arterial flow velocity.


Sound of the heart. Patent ductus in an elderly man.


Roentgenogram of the month. Migrating lung tumor.


The lazy respiratory center--or how to recognize a tired horse. Clinical conference in pulmonary disease from Northwestern University-McGaw Medical Center, Chicago.


Illustrative echocardiogram. Cystic medial necrosis with severe aortic root dilatation.


Selected reports. Spontaneous hemothorax in an otherwise healthy young man.


Subacute bacterial endocarditis in a patient with isolated, nonejection systolic click but without a murmur.


Elimination of diaphragmatic contractions from chronic pacing catheter perforation of the heart by conversion to a unipolar system.


Failure of bronchopulmonary lavage in cystic fibrosis.


Giant bronchial polyp treated by emergency thoracotomy.


Mycobacterium tuberculosis infection of the middle ear.


Letter: Skin testing with multiple PPD antigens in the differential diagnosis of mycobacterial disease.


Letter: Esophageal obstruction during artificial ventilation.


Cardiac performance early after interatrial transposition of venous return in infants and small children.


Intellectual development of children subjected to prolonged circulatory arrest during hypothermic open heart surgery in infancy.


Central nervous system consequences in infants of cardiac surgery using deep hypothermia and circulatory arrest.


Increase in right ventricular volume following valvulotomy for pulmonary atresia or stenosis with intact ventricular septum.


Experience with sixty consecutive ventricular aneurysm resections.


Comparison of three devices to replace the aortic valve.


Conduction defects after cardiac surgery.


Effect of intracoronary tetrodotoxin on recovery of the isolated working rat heart from sixty minutes of ischemia.


Long-term results of mitral annuloplasty in children with rheumatic mitral regurgitation.


Effect of mitral commissurotomy on right-heart work.


Emergency pulmonary embolectomy for massive pulmonary embolism.


Temporal changes in collateral coronary blood flow in ischemic myocardium during intra-aortic balloon pumping.


Effects of external counterpulsation on myocardial ischemia induced by atrial pacing.


Measurement of systolic femoral aterial pressure during reactive hyperemia. An estimate of aortoiliac disease.


Some observations on the RAST test.

Some observations on the RAST test.


Pericardiectomy for treatment of uremic pericarditis.


Office management of patients with urticaria: an analysis of 215 patients.


Letter: Biting insects survey: a statistical report.


Dantrolene sodium for treatment of spasticity.


Hycanthone for schistosomiasis.

Hycanthone for schistosomiasis.


Systemic reactions to hymenoptera stings.


The tortuous basilar artery.

The tortuous basilar artery.


EEG, ECG and other recordings in cerebral angiography.


Abdominal dimensions and thickness of the subcutaneous fat in the fetus.


Elimination of diatrizoate by peritoneal dialysis in renal failure.


Instrument for the removal of a gastric bezoar.


Editorial: The fibreoptic revolution.

Editorial: The fibreoptic revolution.


Editorial: Breast cancer in Japanese migrants.


Editorial: Oestrogens, lipids, and gallstones.


Editorial: Modifications to the breasts.


Iatrogenic osteomalacia and myopathy due to phosphate depletion. In a patient receiving regular dialysis prolonged hypophosphataemia due to aluminium hydroxide therapy resulted in osteomalacia and severe proximal myopathy. Both osteomalacia and myopathy responded to correction of hypophosphataemia without vitamin D therapy.


Conversations on the social services. A paediatric opinion.


Fever in the neutropenic patient.

Fever in the neutropenic patient. A total of 100 consecutive episodes of fever of 101 degrees F (38.3 degrees C) or above in 56 neutropenic patients have been investigated. All the patients had either acute leukaemia or aplastic anaemia. A cause for the fever was found in 68 of these episodes, in 87% of which it was due to infection. The commonest single finding was septicaemia (30 episodes). Only two episodes of fever could be ascribed solely to the underlying malignant disease.Infection should be assumed to be present and the cause of fever in neutropenic patients until proved otherwise.


Letter: Metaclopramide and prolactin.

Letter: Metaclopramide and prolactin.


Letter: Hepatitis B antigen in papular acrodermatitis in children.


Letter: Doctors, drivers, and confidentiality.


Letter: Abdominal decompression in pregnancy.


Letter: Infertility and rubella infection prophylaxis.


Letter: Vitamin A and the teratogenic risks of oral contraceptives.


Letter: Effect of natural oestrogens on coagulation.


Letter: The coroners' so-called 24-hour rule.


Letter: Coxsackie viruses and diabetes mellitus.


Letter: The killer worm.

Letter: The killer worm.


Letter: Was it a drug? Forceval protein.


Letter: Stilboestrol for prostatic cancer.


Letter: Meningioma mimicking features of a phaeochromocytoma.


Letter: The heart during sleep.

Letter: The heart during sleep.


Letter: Blind babies.

Letter: Blind babies.


Letter: Forensic neuropsychiatry.

Letter: Forensic neuropsychiatry.


Private practice: changing the law.

Private practice: changing the law.


Transferrin iron, chelatable iron and ferritin in idiopathic haemochromatosis.


Heparin, platelets and blood coagulation: implications for low-dose heparin prophylactic regimens in venous thrombosis.


Platelet-function studies in patients with glucose-6-phosphate dehydrogenase deficiency.


Cytotoxic ability of peripheral blood lymphocytes from patients with chronic lymphocytic leukaemia.


The effect of splenectomy on the haematological response to radiotherapy in Hodgkin's disease.


The syndrome of hepatitis and aplastic anaemia.


Proceedings: Improvements in frozen blood stored in liquid nitrogen.


Proceedings: The in vitro assay for erythropoietin using mouse foetal liver cells.


Proceedings: The action of salicylate on G6PD-deficient red cells.


Proceedings: Red cell cytochemistry in glucose-6-phosphate dehydrogenase deficiency.


Proceedings: Ferritinaemia and iron status in haemodialysis patients.


Proceedings: Ferritin in normal and leukaemic white blood cells.


Proceedings: Treatment of multiple myeloma by a quadruple chemotherapy regime.


Proceedings: The intracellular location of specific antisera reacting with leukaemic lymphocytes.


Proceedings: Essential thrombocythaemia and peripheral vascular disease.


Editorial: Blood donors and the Transfusion Service.


Letter: Effect on incubating syphilis of penicillin treatment for gonorrhoea.


Editorial: Swimmers' ears.

Editorial: Swimmers' ears.


Editorial: Starving children before operation.


Editorial: Secure hospital units.

Editorial: Secure hospital units.


Editorial: Allergy to aspirin.

Editorial: Allergy to aspirin.


Aspects of plastic surgery. Psychiatric aspects of referral.


Influence of smoking on deep vein thrombosis after myocardial infarction. As part of a study of the factors affecting the risk of deep vein thrombosis after myocardial infarction a surprising and unexplained finding was that non-smokers had a significantly higher incidence of thrombosis than cigarette smokers.


Letter: Vein stripping.

Letter: Vein stripping.


Letter: Tetracyclines after 25 years.

Letter: Tetracyclines after 25 years.


Letter: Types of emphysema.

Letter: Types of emphysema.


Letter: HI antibodies to influenza A-Finland-1-74.


Letter: Hypotension with intravenous salbutamol in premature labour.


Letter: Folic acid supplements for pregnant epileptics.


Letter: Death during dental anaesthesia.


Letter: Flupenthixol decanoate and some aggressive states.


Letter: Measurement of side effects of drugs.


Letter: Community medicine--a disclaimer.


Letter: Democracy in the Health Service.


The role of frozen section in the diagnosis and management of malignant melanoma.


The role of bile acids in the pathogenesis of postvagotomy diarrhoea.


Reconstruction of the pylorus for postvagotomy diarrhoea and dumping.


Aorto-oesophageal fistula: a late complication of a resected coarctation.


Intra-abdominal replacement of the testis as an aid to the repair of difficult and recurrent inguinal hernias.


Obturator hernia.

Obturator hernia.


Posterior rupture of the knee joint in septic arthritis: case report.


Ovarian morphology in early and late human pregnancy.


The effect of oxytocin on local uterine blood flow in women with secondary amenorrhoea and early pregnancy measured by local hydrogen clearance.


Study of glucose-6-phosphate and isocitrate dehydrogenases, DNA, RNA and total nitrogen in the rabbit placenta during its hypertrophic response to ovariectomy.


Detection of fetal heart activity during early pregnancy by combined B-scan and Doppler examination: a new application.


Changes in hemoglobin concentration and hematocrit during the menstrual cycle. I. A cross-sectional study.


A study of seasonal and secular trends in incidence of stillbirths and spontaneous abortions in Sweden.


Placenta praevia and abruptio placentae. Clinical experience with placental scintigraphy and an afterloading technique for indicating the cervix.


Effect of estrogen therapy on climacteric symptoms and tissue changes. The effect of estrogen therapy on climacteric symptoms and tissue changes was studied in 100 castrated women.  1/2 of the women received 2 mg/day estriol succinate and 1/2 received 2 mg/day estradiol valerate for 6 months beginning 1 month postcastration.  Measurements were made of the thickness of the epidermis before treatment and after 3 and 6 months.  5 patients did not respond to the estriol succinate and 1 did not respond to the estradiol valerate.  Urinary estrogens were high in all cases after 3 and 6 months of treatment.  The effect of estriol succinate revealed significant ( p less than .01) thickening of the epidermis in 3 out of 5 cases after 3 months of treatment.  There was little difference between 3- and 6-month specimens.  The estrogen effect in the vaginal smears was usually weak after both 3 and 6 months.  It was concluded that estrogen substitution may play a role in preventing postmenopausal degenerative changes.


Complications following the intra-amniotic administration of prostaglandin f-2-alpha for therapeutic abortion.


Fetal paroxysmal supraventricular tachycardia. Report of a case documented by trans-vaginal electrocardiogram during fetal distress in labour.


Evaluation of immunological reactivity in bladder cancer.


Simple renal hypothermia.

Simple renal hypothermia.


Some aspects of the adult urinary stone problem in Great Britain and Northern Ireland.


The control of severe bleeding from the bladder by intravesical hyperbaric therapy.


Broncho-pleuro-colonic fistula secondary to pyonephrosis.


Pneumoscrotum complicating pneumothorax and surgical emphysema.


Appendiculo-vesical fistula with stone in the appendix.


Knots in the bladder.

Knots in the bladder.


The effect of ambient temperature on the thiamin requirement of growing-finishing pigs.


The effect of experimental variation in the quantity of pancreatic secretion on the digestion and utilization of milk-substitute diets by the calf.


Effect of processing of cereals on rumen fermentation, digestibility, rumination time, and firmness of subcutaneous fat in lambs.


Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years.


Protein metabolism in skeletal muscle: the effect of feeding and fasting on muscle RNA, free amino acids and plasma insulin concentrations.


Urinary excretion of short-chain fatty acids in latent pernicious anaemia and related conditions.


Serum vitamin E levels with beta-thalassaemia major: preliminary report.


An electron microscopic study of the nuclear abnormalities in erythroblasts in beta-thalassaemia major.


Corticosteroid therapy in Felty's syndrome and its effect on hypersplenic rats.


Rapid stem cell differentiation induced by 19-nortestosterone decanoate.


Regulation of human bone marrow leucopoiesis.


The absorption of human factor VIII neutralizing antibody by factor VIII.


A new haemorrhagic disorder with defective fibrin stabilization and cryofibrinogenaemia.


Separation and partial characterization of a coagulant enzyme from Bitis gabonica venom.


Two protein and two RNA species in particles of strawberry latent ringspot virus.


The replication of Semliki Forest virus.


The subcellular localization of virus-specific RNA in influenza virus-infected cells.


The characterization of Bacteroides fragilis bacteriophage recovered from animal sera: observations on the nature of bacteroides phage carrier cultures.


Microangiographic observations on the uterine and maternal placental vasculature in early human pregnancy.


Nicotine and cotinine in the amniotic fluid of smokers in the second trimester of pregnancy.


The effect of placental insufficiency on fetal and adult hemoglobin synthesis.


The induction of immunological tolerance to the parasitic nematode Trichuris muris in cortisone-treated mice.


The ultrastructure of the arterial supply of the human placenta in early and late pregnancy.


L-asparaginase and in vitro lymphocyte blastogenesis. Cell membrane alteration as possible mechanism of inhibitory effect.


The evaluation of hydrocortisone antibodies produced in rabbits and sheep. I. Radioimmunoassay.


Peripheral haemodynamic effects of combined oestrogen-progestogen oral contraceptives.


Release of an immunologically active humoral factor from the isolated perfused thymus.


Hypertension in pregnancy.

Hypertension in pregnancy.


The relation between a large baby at birth and diminished maternal first phase insulin response to glucose.


Cyanotic congenital heart disease and pregnancy.


Intra-amniotic prostaglandin for induction of abortion: an improved regime using prostaglandin E2.


The diameter of the uterine isthmus during the menstrual cycle, pregnancy and the puerperium.


Human growth hormone (HGH), thyroid stimulating hormone (TSH) and cortisol levels in the serum of menstruating Thai women.


Progesterone inhibition of human myometrium creatine phosphokinase activity in the non-gravid subject.


Carboxyhemoglobin sources in the metropolitan St. Louis population.


Smoking and carboxyhemoglobin in the St. Louis metropolitan population: theoretical and empirical considerations.


Chronic respiratory disease in four occupational groups.


Early detection of expiratory airflow obstruction in cement workers.


Effect of lead on delta-aminolevulinic acid dehydratase activity in red blood cells. II. Regeneration of enzyme after cessation of lead exposure.


Slowed learning in lambs prenatally exposed to lead.


Biological response and subjective symptoms in low level lead exposure.


Pulmonary lesions induced by chronic exposure to ozone. I. Biochemical alterations.


Effect of malathion on oxygen consumption and blood cholinesterase of the hen.


Smoking habits and pain tolerance.

Smoking habits and pain tolerance.


Editorial: Hunkah.

Editorial: Hunkah.


The effects of sodium fluoride on bone breaking strength.


Secretory territories and rate of matrix production of osteoblasts.


Simultaneous determination of blood flow in cortical bone, marrow, and muscle in canine hind leg by femoral artery catheterization.


The dissolution of single crystals of hydroxyapatite in citric and lactic acids.


Additional evidence for the binding of calcium ions to elastin at neutral sites.


The influence of substrata on calcification patterns in molluscan shell.


Increased bone microhardness in fluoride treated rats.


Structure of long bones of rats and mice fed a low calcium diet.


The response of brain-damaged patients to a rehabilitation regime.


Popliteal cysts and synovial rupture in osteoarthrosis.


The effects of therapeutic forms of heat and ice on the pain threshold of the normal shoulder.


Studies on matrix proteins of normal and lathyritic rat bone and dentine.


Fungal osteoclasia: a model of dead bone resorption.


Ultrastructure and growth of the sea urchin tooth.


An improved model system for the study of bone repair.


Asbestiform amphibole minerals: detection and measurement of high concentrations in municipal water supplies. Ashestiform amphibole minerals, which have been demonstrated to be associated with human health problems, have been detected in substantial quantities in municipal water supplies taken from western Lake Superior Water. The total concentrationl of amphibole minerals in the Duluth, Minnesota, water supply, as measured by x-ray diffraction for daily samples of suspended solids averages 0.19 milligram per liter with large fluctuations due to seasonal and climatological effects on lake circulation. Electron microscopic examination of these water samples confirms the presence of asbestiform amphibole fibers. A conservatiue estimate of the fiber count for 1973 Duluth water supply samples is (1 to 30) x 10(6) amphibole fibers identifiable by electron diffraction per liter of water with a mass concentration of 1 to 30 micrograms per liter.


Amino acid difference formula to help explain protein evolution. A formula for diference between amino acids combines properties that correlate best with protein residue substitution frequencies: composition, polarity, and molecular volume. Substitution frequencies agree much better with overall chemical difference between exchanging residues than with minimum base changes between their codons. Correlation coefficients show that fixation of mutations between dissimilar amino acids is generally rare.


Inert gas narcosis, the high pressure neurological syndrome, and the critical volume hypothesis. The hypothesis that general anesthesia or pressure-induced convulsions occur when a hydrophobic region is expanded or compressed, respectively, by critical amounts is consistent with recent data obtained with mice. Calculations show that anesthesia occurs at an expansion of 1.1 percent and convulsions at a compression of 0.85 percent, the latter site of action being more compressible.


Ultrastructural changes in the nematode Anguina tritici associated with anhydrobiosis.


Ultrastructure of carnation etched ring virus-infected Saponaria vaccaria and Dianthus caryophyllus.


Quantitative parameters in affinity chromatography.


Purification of acetylcholinesterase by covalent affinity chromatography.


Lactose immobilized on stainless steel and other dense metal and metal oxide supports.


Water encapsulated enzymes in an oil-continuous reactor-kinetics and reactivity.


Effect of dietary protein and amino acid mixture on protein synthesis in vitro in rat liver.


Insulin sensitivity in vitamin B 6-deficient rats. Effects of acute and chronic growth hormone treatment.


Role of gastric acid in the utilization of dietary calcium by the rat.


The effects of synthetic estrogens on the metabolic clearance and production rates of estrone and estradiol.


The pituitary-gonadal axis before puberty: effects of various estrogenic steroids in the ovariectomized rat.


Determination of progesterone and of free and conjugated estrogens in pregnant and peudo-pregnant rats.


Synthesis and antiestrogenic activity of 2,4-bis(bromomethyl)-estrone methyl ether: a bifunctional alkylating steroid.


Intramolecular cyclisation reactions of 5beta-cholan-24-amide, 3alpha-acetoxy-5beta-cholan-24-amide, and 3alpha-acetoxy-5beta-cholan-24-ol.


A simple preparation of 2-methyl-5alpha-cholest-2-ene.


The problem of interrelationship of structure and function.


[Lumbo-sacral diagnosis with Dimer-X].

[Lumbo-sacral diagnosis with Dimer-X].


Presidential address. Surgical education: change for the sake of change?


Banked autologous blood in elective surgery.


Predictive criteria for the selection of breast cancer patients for adrenalectomy.


Noninvasive carotid bifurcation mapping. Its relation to carotid surgery.


Traumatic injuries of the diaphragm. Diaphragmatic hernia.


Effect of thymectomy in patients with myasthenia gravis. A sixteen year experience.


Comparison of end to side and side to side portacaval shunts in dogs and human subjects with cirrhosis and portal hypertension.


Value of selective and truncal vagotomy in massive bowel resection.


Postoperative radiation in the treatment of carcinoma of the breast.


The role of the mental health counselor in the psychiatric liaison service of the general hospital.


The attitudes of physicians toward prolonging life.


Intrusions of territory and personal space: an exploratory study of anxiety-inducing factors in hospitalized patients.


Notes on a contextual approach to medical ward consultation: the importance of social system mythology.


Psychiatric aspects of life-threatening illness: a course for medical students.


A field study of nonverbal creativity.

A field study of nonverbal creativity.


The effect of three types of arbitrary thwarting on the instigation to aggression.


Extraversion, arousal, and retrieval from semantic memory.


Aggression-guilt and conditionability for aggressiveness.


Polyamine metabolism in tumor, spleen and liver of tumor-bearing rats.


Comparative effect of local radiotherapy and surgery on cell-mediated immunity against a mouse transplantable mammary tumor.


Control of tumor growth in mice by thoracic duct drainage: relationship to blocking factor in lymph.


Stimulation of tumor growth by the immune response.


Immune cytolysis of murine tumor cells mediated by xenogeneic "immune" RNA.


The effect of year of birth on the breast cancer age-incidence curve in Iceland.


Growth stimulation of human diploid fibro-blasts by the tumor promoter, 12-0-tetradecanoly-phorbol-13-acetate.


Postoral peripheral retinal tears.

Postoral peripheral retinal tears.


Toxoplasmosis with microcephaly.

Toxoplasmosis with microcephaly.


The Clonidine side effect in the human eye.


Specimen stand for the Zeiss Photo Slit Lamp.


A simplified way to remove pterygia.

A simplified way to remove pterygia.


Editorial: Trials and tribulations of an editor.


Philosophical reflections on evaluation.


Complications of assisted ventilation. A prospective study of 354 consecutive episodes.


Small airway disease. An assessment of the tests of peripheral airway function.


Bronchial component in chronic obstructive lung disease.


Pleural involvement in sarcoidosis.

Pleural involvement in sarcoidosis.


Prediction and potential prevention of industrial bronchitis. An epidemiologic study of a group of coke oven workers.


Endocarditis due to group D streptococci. Comparison of disease caused by streptococcus bovis with that produced by the enterococci.


Echocardiographic detection of abnormal motion of the interventricular septum in ischemic cardiomyopathy.


Pseudoatrial gallop with atrioventricular block. Demonstration of a possible mechanism by echocardiography.


Circadian rhythms in urinary light chains, serum iron and other variables of multiple myeloma patients.


Circadian variation of urinary 17-hydroxycorticosteroid excretion in relation to dexamethasone-induced adrenocortical suppression.


A physiological model for circadian rhythms derived from the acetabularia rhythm paradoxes.


The four-hour feeding rhythm of the baby as a free running endogenously regulated rhythm.


Menstrual cycle variations in cognitive ability: a preliminary report.


More on educative chronobiology, health and the computer.


Early circannual rhythms and adult human behaviour: components of a chronobehavioural theory, and critique of persistent artifacts.


Letter: Biorhythms.

Letter: Biorhythms.


Modest population gains in the United States and Canada.


Mortality of anesthesiologists.

Mortality of anesthesiologists.


Retinoblastoma in Hungary, 1960-1968.

Retinoblastoma in Hungary, 1960-1968.


Water Surveillance Network, first quarter 1974.


Chromosome studies in twelve patients with retinoblastoma.


ERAMS Surface and Drinking Water Components October-December 1973.


Radioactivity in New York State surface water January-December 1972.


Radioactivity in airborne particulates and precipitation.


Use of the principles and methods of radioecology in solving some current problems of man's effect on the environment.


Influence of the conditions of soil moisture on the passage of strontium-90, cesium-137, and cerium-144 from the soil into solution.


Population dynamics and prospects for growth in the fur-seal stock of the Kurile Islands.


Analysis of the constant used in indirect calorimetry of birds and mammals.


Rate of the development of forms and adaptive evolution in beetle mites.


Productivity dynamics of moose in Estonia.


Coupled levels of thermal stability of aldolase and cholinesterase of muscle homogenates of closely related species of aquatic animals.


Releasing signals in the mating of frogs of closely related species.


Nature of the variability of the color of wood mice in various regions of the range of the species.


A pen-recorder for bird movements during the nesting period.


Variation in the visceral characteristics of the willow ptarmigan (Lagopus albus) and common ptarmigan (Lagopus mutus) in the Taimir Peninsula.


Change in planktonic complexes in the eutrophic Lake Baltym due to overgrowth by weed.


Cancer control problems in Europe: introduction.


Cancer as a public health problem.

Cancer as a public health problem.


Prevention of malignant neoplasms.

Prevention of malignant neoplasms.


The place of epidemiology in cancer control.


The role of the cancer registry in cancer control.


Organization of cancer control in France.


Roumanian experience in detection methods of early stages of cancer.


An outline on the organization of cancer control in Italy.


The present situation of cancer control in Czechoslovakia.


Gastric cancer control.

Gastric cancer control.


The control of stomach cancer.

The control of stomach cancer.


Atrophic gastritis: a possible pre-cancerous condition.


A precision hand trimmer for electron microscope tissue blocks.


Hepatic glycogen patterns in fasted and fed rats.


Formation of central and peripheral myelin sheaths in the rat: an electron microscopic study.


Studies on the response of the adult newt kidney to partial nephrectomy.


Hydrolytic enzyme activity during endochondral ossification of secondary cartilage.


The influence of serum components on the growth and mutation of Chinese hamster cells in medium containing aminopterin.


Repair of lesions induced in human liver cell DNA by N-nitroso compounds as measured by the bromodeoxyuridine photolysis method.


Clones of Chinese hamster cells cultivated in vitro not permanently resistant to azaguanine.


DNA repair synthesis and chromosomal aberrations induced in vivo by triethylenemelamine.


The role of 8-azaguanine in the selection from human diploid cells of mutants deficient in hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT).


Induction and analysis of revertants from various arg-7 mutants lacking argininosuccinate lyase in Chlamydomonas reinhardi.


Radiological diagnosis of left ventricular failure in acute myocardial infarction. Correlation with rales, gallop rhythm, PaO2 cardiac size and circulation time.


Combinations of mutagens: distinguishing possible outcomes.


Frequency of spontaneous translocations in mouse spermatogonia.


Ligation of patent ductus arteriosus for persistent respiratory distress syndrome in premature infants.


Vitelline artery and vein remnants as a cause of intestinal obstruction.


Surgery for developmental and growth failure in childhood granulomatous enteritis.


Repair of esophageal atresia by end-to-side anastomosis and ligation of the tracheoesophageal fistula: a critical review of 18 cases.


Inguinal hernia after ventriculoperitoneal shunt for hydrocephalus.


Experimental treatment of corrosive esophageal burns.


Jejunoileal bypass for morbid obesity in adolescents.


Hepatic portoenterostomy--is it indicated in the treatment of biliary atresia?


Resistant esophageal stenosis associated with reflux after repair of esophageal atresia: a therapeutic approach.


Elongation of the upper pouch and delayed anatomic reconstruction in esophageal atresia.


Management of chylothorax in children by thoracentesis and medium-chain triglyceride feedings.


An improved technique for the correction of congenital duodenal obstruction in the neonate.


Sacrococcygeal teratoma: American Academy of Pediatrics Surgical Section Survey-1973.


Benign mediastinal lipoblastomatosis.

Benign mediastinal lipoblastomatosis.


Large intrathoracic superior sulcus cystic mass arising from the brachial plexus in childhood.


Dumbbell type rhabdomyosarcoma in an infant.


Congenital segmental dilatation of the jejunum.


Eventration of the diaphragm with gastric perforation.


Successful use of the gallbladder to establish drainage in a case of extrahepatic bilary atresia.


Congenital pulmonary cysts versus a differential diagnosis in the newborn: diaphragmatic hernia.


Congenital lumbar hernia.

Congenital lumbar hernia.


Multilocular cystic dysplasia of half of a horseshoe kidney.


Protrusion and torsion of an inguinal hernia sac inside a hydrocele of the scrotum.


Transverse testicular ectopia: preoperative diagnosis.


Ultrastructure of the vessel wall in fat embolism and electron microscopy of fat phagocytosis and transport by blood platelets.


Dietary fat and arterial thrombosis: role of blood clotting.


Platelet survival time in angina pectoris and hyperlipoproteinaemia.


Effect of high plasma FFA induced by heparin during alimentary hyperlipaemia on platelets.


Alfa-tocopherol (vitamin-E) in human platelets.


Phospholipid transfer between plasma and platelets in vitro.


A possible thrombo-protective role for plasma lysolecithin in man.


Assessment of procoagulant activity of phospholipids with a venom specific inhibitor.


Prostaglandins, essential fatty acids, platelet function and thrombosis.


Lipolytic activity in human blood platelets.


The social system and children's behavior problems.


An intercultural study of aggressive behavior on children's playgrounds.


The eye of the beholder: parents' view on sex of newborns.


Engrossment: the newborn's impact upon the father.


Is there a new work ethic?

Is there a new work ethic?


A national study of the knowledge, attitudes and patterns of use of drugs by disadvantaged adolescents.