Studies on insect dormancy. II. Relationship of cold-hardiness to diapause and quiescence in the eastern tent caterpillar, Malacosoma americanum (Fab.), (Lasiocampidae: Lepidoptera).


Hormonal control of protein sequestration in the fat body of Calpodes ethlius Stoll.


Two cases of human Sarcophaga (Diptera: Sarcophagidae) myiasis in Quebec, with descriptions of the larvae.


A telemetric study of the abdominal temperature of a hibernator, Spermophilus richardsonii, maintained under constant conditions of temperature and light during the active season.


Procedure for mass collection of mermithid postparasites (Nematoda: Mermithidae) from larval blackflies (Diptera: Simuliidae).


Production of surface casts by the earthworm Eisenia rosea.


New compounds obtained by direct condensation of 2-halopyridines with benzo-1,2,3-triazole.


Decomposition of 1-(2'-pyridyl)-benzo-1,2,3-triazole derivatives in polyphosphoric acid.


Interrelationship between the silk gland and other tissues in protein metabolism in the latest larval stage of the silkworm, Bombyx mori.


Structure of the visual system of the two-spotted spider-mite, Tetranychus urticae.


Control of oötheca formation and oviposition in Blattaria.


Lipid composition of the fat body and haemolymph and its relation to lipid release in Oncopeltus fasciatus.


Growth and silk formation of silkworm larvae influenced by phytoecdysones.


The rŏle of amino acids in diet intake and selection and the utilization of dipeptides by Aphis fabae.


Relationship between hormone titres and RNA and protein syntheses when the change to the pupal programme occurs in the silkworm, Bombyx mori.


On the metabolism of N-acetyldopamine in Periplaneta americana.


Characterization of alpha-glucosidase at the tips of the chemosensory setae of the fly, Phormia regina.


The utilization of recently assimilated carbon in graminaceous plants.


Podiatry and the hospital.

Podiatry and the hospital.


Podiatry in today's hospital.

Podiatry in today's hospital.


The podiatric residency: a seventeen-year experience.


The role of the podiatric surgical resident in the general hospital.


A well rounded podiatry residency serves in three directions.


Editorial: Podiatry and clinical privileges in accredited hospitals.


Editorial: Writing for the Journal.

Editorial: Writing for the Journal.


Notes on legal aspects of hospital privileges.


Manic-depressive psychosis or manic-melancholic mode.


Does per-operative pneumatic tourniquet cause thrombosis?


Transplantations of small intestines.

Transplantations of small intestines.


Yersiniosis in children.

Yersiniosis in children. Sixty-five strains of Yersinia enterocolitica were isolated from stool specimens obtained from 35 patients over a 12-month period. The microbiologic characteristics and drug sensitivities are reported and the clinical patterns of disease associated with the organism are described. Gastroenteritis affecting infants and young children is the most frequent manifestation. The data for 1972 show the same epidemiological trend as in preceding years.


Incidence of HL-A antigens in the Japanese population of Hawaii.


Alteration of serum lipids in a group of free-living adult males.


Fatty acid absorption in jejunal autograft and allograft.


Experimental cancer immunotherapy using a neuraminidase-treated non-viable frozen tumor vaccine.


The adequacy of myocardial oxygen delivery in acute normovolemic anemia.


An experimental study of the antral gastrin mechanism.


The prevention and treatment of the persistent perineal sinus.


Delayed presentation of carotid intimal tear following blunt craniocervical trauma.


Ultrapore filter-induced thrombocytopenia.


Venous drainage of the ischemic kidney.

Venous drainage of the ischemic kidney.


The blood supply of experimental liver metastases. IV. Changes in vascularity with increasing tumor growth.


The crossover femoropopliteal bypass.

The crossover femoropopliteal bypass.


Inferior vena caval obstruction caused by expansion of an abdominal aortic aneurysm: report of a case and review of the literature.


Amyloidoma (a solitary nodule of the lung).


Editorial: A single step.

Editorial: A single step.


Editorial: Magnification and coronary artery surgery.


Letters to the editors: The young surgeon's dilemma.


Clinical chemical examination of a case of left-sided abomasal displacement, changing to right-sided abomasal displacement.


Estrogenic and anti-estrogenic characteristics of common Finnish fodders.


A modified method for isolating lymphocytes from peripheral blood with the use of the iodamide contrast medium urografin.


Studies on bile secretion in man. 3. Influence of sodium dehydrocholate, a diuretic and glucagon on bile secretion.


The effect of DL-cysteine hydrochloride on in situ thymus cells.


Disorders of porphyrin metabolism induced with 2-allyloxy-3-methylbenzamide in healthy rats and rats bearing transplantable Yoshida sarcoma.


Studies of cancer patients treated with acridine derivative (C-283). V. Lactate dehydrogenase of serum, leukocytes and erythrocytes.


The use of defatted cellulose for purification of amylopectin.


A rapid method for the preparation of (125I)alpha-bungarotoxin.


Intestinal alkaline phosphatase. Catalytic properties and half of the sites reactivity.


Molecular weight and subunit structure of bovine adrenal glucose-6-phosphate dehydrogenase.


Selenium as a component of glutathione periodase isolated from ovine erythrocytes.


Cupric ion-adenosine triphosphate system. Proton magnetic resonance line-broadening studies.


Affirmation of critical proton magnetic resonance data on the solution conformation of the valinomycin-potassium ion complex.


Nuclear magnetic resonance studies of the solution properties of the antiviral nucleoside, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, the coresponding 5'-phosphate, and related triazole nucleosides.


Theory of sedimentation for kinetically controlled dimerization reactions.


The amino acid sequence of porcine parathyroid hormone.


Use of antibodies for the isolation of biologically pure messenger ribonucleic acid from fully functional eukaryotic cells.


Chemically defined inducers of alkylsulphatases present in Pseudomonas C12B. When Pseudomonas C12B is grown on nutrient broth to the stationary phase, cell extracts contain two secondary alkylsulphatases (S1 and S2) active towards potassium decan-5-yl sulphate but not towards potassium pentan-3-yl sulphate and one primary alkylsulphatase (P1) active towards sodium dodecan-1-yl sulphate (sodium dodecyl sulphate). When 10mm-sodium hexan-1-yl sulphate is included in the nutrient broth an additional primary alkylsulphatase (P2) is produced. The S1, S2, P1 and P2 enzymes are also present in extracts of cells grown on broth containing the commercial detergent Oronite, together with an additional secondary alkylsulphatase (S3) active towards pentan-3-yl sulphate as well as decan-5-yl sulphate. The P2 primary alkylsulphatase can be induced by a number of primary and secondary alkyl sulphate esters but the induction of the S3 enzyme appears to be a more specific and complex process. Studies on the ability of different fractions separated from Oronite to act as inducers suggest that the combination of a long-chain secondary alkyl sulphate(s) and a long-chain secondary alcohol(s) is responsible for the appearance of the S3 enzyme. Potassium hexadecan-2-yl sulphate or potassium tetradecan-2-yl sulphate, in combination with either hexadecan-2-ol or tetradecan-2-ol, can serve as inducers for the enzyme. Some characteristics of these specific inducer systems have been elucidated.


Characteristics of mitochondrial and microsonal monoacyl- and diacylglycerol 3-phosphate biosynthesis in rabbit heart. Acylation of sn-glycerol 3-phosphate by heart subcellular fractions was characterized. The enzyme kinetics revealed that the rate of reaction of acylation by mitochondria was slower, but constant for a longer period (up to 20min), than that by the microsomal fraction. The range of palmitate, oleate and linoleate concentrations yielding optimal sn-glycerol 3-phosphate acylation was broader for mitochondria than for the microsomal fraction, the latter showing a preference for linoleate. The mitochondrial fraction synthesized a relatively large quantity of monoacyl-sn-glycerol 3-phosphate, reaching 135% of the microsomal biosynthesis during an assay period of 15min. By contrast, the microsomal fraction formed considerably more diacyl- than monoacyl-sn-glycerol 3-phosphate, except with linoleate as the acyl donor, in which case approximately equal quantities of the two products were produced. The biosynthesis of monoacyl-sn-glycerol 3-phosphate was also observed in experiments in which hepatic subcellular fractions were used to provide supporting evidence. Cardiac mitochondrial diacyl-sn-glycerol 3-phosphate formation was less than 17% of the microsomal formation. However, evidence is presented to exclude the possibility that monoacyl-sn-glycerol 3-phosphate in the mitochondrial fraction is formed by deacylation of the contaminating microsomal diacyl-sn-glycerol 3-phosphate. The participation of the dihydroxyacetone phosphate pathway in the biosynthesis of these substances was minimal. The addition of CTP and the fatty acid specificity of the reaction both provided results that reinforced the postulate that mitochondrial differs from microsomal acylation. Thus our findings demonstrate that the characteristics of acyl-CoA-sn-glycerol 3-phosphate O-acyltransferase (EC 2.3.1.15) in rabbit heart mitochondria are distinct from those of cardiac microsomal enzyme and hepatic enzymes.


Oxidation of formate by peroxisomes and mitochondria from spinach leaves. 1. Spinach (Spinacia oleracea L.) leaf extracts catalyse the oxidation of formate to CO(2). 2. Two enzymic systems are responsible for this oxidation, the peroxidatic action of catalase (EC 1.11.1.6) and NAD-dependent formate dehydrogenase (EC 1.2.1.2). 3. Formate dehydrogenase is mainly, if not exclusively, located in the mitochondria. This enzyme has a pH optimum of 6-6.5 and a K(m) for formate of 1.7mm in the presence of 1 mm-NAD(+). 4. Peroxidatic action of catalase is presumed to take place in peroxisomes, since these seem to be the subcellular site of catalase. Formate oxidation at pH5 by chloroplast and mitochondrial fractions is due to their ability to generate H(2)O(2) and the presence of contaminating catalase. 5. During photorespiration, peroxidatic oxidation of formate by catalase can occur over a wide range of pH values, but the rate of this reaction is probably controlled by the concentration of formate present, to an extent dependent on the pH.


Induction of primary alkysulphatases and metabolism of sodium hexan-1-yl sulphate by Pseudomonas C12B. Sodium hexan-1-yl sulphate and certain related alkyl sulphate esters have been shown to serve as inducers of the formation of primary alkylsulphatases (designated as P1 and P2) in Pseudomonas C12B. When the organism is grown on sodium hexan-1-yl [(35)S]sulphate as the sole source of sulphur or as the sole source of carbon and sulphur only the P2 alkylsulphatase is formed and inorganic (35)SO(4) (2-) is liberated into the media. Cell extracts contain this anion as the major (35)S-labelled metabolite although two unidentified labelled metabolites as well as choline O-[(35)S]sulphate occur in trace quantities in some extracts. Dialysed cell extracts are capable of liberating inorganic (35)SO(4) (2-) from sodium hexan-1-yl [(35)S]sulphate without the need to include cofactors known to be required for the bacterial degradation of n-alkanes. The collective results suggest that sodium hexan-1-yl sulphate can act as an inducer of P1 alkylsulphatase formation without the need for prior metabolic modification of the carbon moiety of the ester.


Calcium transport in the early conceptus and associated maternal tissues in the rabbit. 1. The kinetics of calcium transport were studied in unmated (oestrous) and pregnant rabbits in the first half of gestation, with the aim of establishing evidence of hormonal (ovarian) influence on the pattern of transport. 2. The following tissues were examined at short- (45min and 2h) and long-duration (4, 16 and 48h) intervals after parenteral administration of (45)Ca or (47)Ca: maternal blood plasma, endometrium, uterine fluid, placental tissues, two developmentally disparate stages of rabbit conceptus, namely the unattached blastocyst and the early post-implantation foetus, and bone (femur). 3. Marked variability in calcium content characterized rabbit tissues and body fluids. 4. Compartmental analysis was applied to measurements of specific radioactivity. Oestrous endometrium had the largest rapidly exchanging calcium fraction (turnover time of 12min) and the highest value for calcium flux (500mug of Ca exchanged/h per g fresh wt. of tissue). A marked downward gradient in values of flux existed between the progestational endometrium, uterine fluid and blastocyst; there was a similar gradient between placental tissues and foetus. 5. An hormonal influence on calcium transport was evident in (i) the decrease in specific radioactivity of rabbit blood plasma with advancing pregnancy, (ii) the extraordinarily rapid calcium transport between blood plasma and endometrium, especially in the oestrous stage, and (iii) the effectiveness of ovarian hormone substitution in ovariectomized rabbits. 6. The very low specific radioactivity recorded for bone indicated that only a minute fraction of its calcium was exchanging with that of blood plasma under the experimental conditions examined. 7. The rate of uptake of (45)Ca by rabbit blastocysts growing in vitro was one-tenth of that of (22)Na, or that recorded for calcium in vivo. 8. Inhibition of carbonic anhydrase activity with acetazolamide in vivo, in maternal erythrocytes, endometrium and placental tissues, produced no appreciable changes in calcium uptake in these tissues or other systems examined as a routine on either day 6 or days 12-14 of gestation.


Weighting functions and data truncation in the fitting of multi-exponential functions. Artificial data were simulated by using two-exponential functions and normally distributed pseudo-random numbers. The variation corresponded to either constant or relative variance for the data error. These data were used to test (i) three different weighting functions and (ii) the effect of data truncation on the precision of estimating the parameters of two-exponential functions.


Experience in the management of surgically correctable biliary atresia.


The effect of amantadine, L-dopa, (plus)-amphetamine and apomorphine on the acquisition of the conditioned avoidance response.


Effects of physostigmine on the maintenance of discrimination behaviour in rats.


A comparative study of dantrolene sodium and other skeletal muscle relaxants with the Straub tail mouse.


Hyperthermic effect of palmitate sodium, stearate sodium and oleate sodium injected into the cerebral ventricles of conscious cats.


Influence of temperature on retinal ganglion cell response and E.R.G. of goldfish. 1. Extracellular recordings were made from the colour and spatial coded ganglion cells in the isolated goldfish retina.2. Electroretinograms (e.r.g.s) were obtained from unanaesthetized goldfish.3. For both types of responses the amplitude and phase characteristics were determined at various temperatures by means of Gaussian noise modulated light.4. The shape of these characteristics, depicted as Bode plots, is invariant with temperature. For the ganglion cell responses this holds from 7 to 19 degrees C, whereas for the e.r.g.s invariance is found over the entire range of temperatures used (6-30 degrees C).5. To obtain overlapping Bode plots shifts along the frequency axis are needed that are in accordance with the Arrhenius relation. The Q(10) of the e.r.g. is about 1.9 and of the spike response about 2.7.6. These relatively low values of Q(10) indicate that the dynamics of retinal signal transformations are dominated by diffusion controlled reactions. This implies that real transport delays can be neglected in retinal input-output relations.7. To verify whether a relationship exists between temperature and spectral coding, as has been suggested on the basis of behavioural studies, photopic e.r.g. action spectra were recorded and the spectral coding of ganglion cells were determined as a function of temperature.8. The results point to a temperature invariance of both the photopic e.r.g. action spectra and the colour coding of ganglion cell responses.9. The general conclusion of this study is that ;rules' found in the poikilothermic goldfish are not bound by temperature.


The regulation of cellular volume in liver slices. 1. Rat, rabbit and guinea-pig liver slices were incubated in media at 37 degrees C to study effects of ouabain and of metabolic inhibition on tissue composition.2. Slices initially incubated in oxygenated balanced medium did not swell when exposed to either balanced media or potassium-free media containing ouabain in concentrations ranging from 0.1 to 10 mM though they lost potassium and gained a comparable amount of sodium.3. Without prior incubation in oxygenated medium slices initially swelled when incubated with ouabain but then maintained their new volume.4. Slices whose metabolism was inhibited by incubation with nitrogen and 1 or 10 mM iodoacetamide lost as much potassium as slices exposed to 10 mM ouabain but became swollen with the uptake of sodium, chloride and water.5. The results show that liver cells, like renal cortical cells, possess a metabolically dependent, ouabain-insensitive, potassium-independent mechanism concerned in the regulation of cellular volume.


The compensation of post-traumatic oedema in the rabbit at different ages. 1. The compensation of fluid loss from the circulation after an LD(50) period of bilateral hind-limb ischaemia in a thermoneutral environment has been studied in the rabbit from birth until young adulthood.2. The fluid loss from the circulation was calculated from the increase in the great vessel haematocrit value as the red cell volume and F(cells) were unchanged after limb ischaemia. This ;apparent' fluid loss was compared with the ;actual' fluid loss calculated from the increase in water content of the injured limbs.3. The 0- to 1-day-old rabbit was better able to restore fluid, and protein, to the circulation than the older animal and suffered a smaller percentage reduction in arterial blood pressure after an LD(50) period of ischaemia.4. The better compensation of post-traumatic fluid loss during the first 48 hr of life may be explained by the high capillary filtration coefficient and the post-traumatic increase in plasma protein osmotic pressure found at that age.5. The more efficient restoration of the plasma volume by the 0- to 1-day-old rabbit may account for the increased ability to withstand post-traumatic fluid loss at that age.


Studies of radiocalcium efflux in single barnacle muscle fibres: effects of procaine and external divalent cations. 1. (45)Ca efflux from single barnacle muscle fibres loaded with radio-calcium by microinjection was studied.2. The (45)Ca washout curve consisted of three exponential phases with half-times of 4.8, 12.6 and 111.1 min.3. Removal of external Ca(2+) reduced (45)Ca efflux by 65%. The (45)Ca efflux recovered upon restoring external Ca(2+), the magnitude of the recovery being dependent upon the external Ca(2+) concentration. 10 mM procaine was found to reduce the magnitude of the recovery.4. Removal of external Mg(2+) resulted in a 38% increase in (45)Ca efflux.5. External application of procaine at pH 7.8 caused a dose-dependent inhibition of (45)Ca efflux. The magnitude of the inhibition was reduced in the presence of low external Ca(2+) concentrations. 10 mM procaine at pH 9.3 caused a biphasic effect: inhibition was followed by stimulation.6. Microinjection of 0.5 M procaine caused only inhibition of (45)Ca efflux, whereas microinjection of 1.5 M procaine caused stimulation followed by inhibition. These effects were observed at an external pH of 7.8 and 9.3.7. Injection of 100 mM-EGTA abolished the stimulatory but not the inhibitory effect produced by procaine injection.8. These results are interpreted as indicating that a major fraction of the (45)Ca efflux involves Ca-Ca exchange which is inhibited by the charged form of procaine in a non-competitive manner at the external surface of the muscle fibre. The stimulatory action is attributed to release by procaine of Ca(2+) from internal binding sites.


Polysensory interactions in the cuneate nucleus. 1. The effects of light flashes or sound clicks on somatic sensory activity in the cuneate nucleus of the cat were studied. Polysensory interactions were demonstrated by means of gross potential recording in the cuneate nucleus or medial lemniscus, single unit recording in the cuneate nucleus, and excitability testing of tract terminals.2. Brief flashes or clicks were found to produce negative (N) and positive (P) waves in the cuneate nucleus similar to those produced by cutaneous stimulation. Furthermore, the P wave evoked by conditioning photic or acoustic stimuli depressed the P wave produced by cutaneous test stimuli.3. Conditioning photic or acoustic stimuli inhibited spontaneously firing cuneate neurones as well as those driven by cutaneous test stimuli.4. Conditioning photic or acoustic stimuli depressed the test discharge in the medial lemniscus evoked by cutaneous test stimuli.5. Micro-electrode stimulation within the cuneate nucleus evoked an antidromic response in the superficial radial nerve consisting of two spike complexes. Conditioning photic or acoustic stimuli caused an increase in the size of the initial spike complex and a depression in the secondary spike complex. These changes and the time courses of all the interactions observed were suggestive of presynaptic inhibition.6. The modulatory influences of photic and acoustic stimuli on the cuneate nucleus were present under alpha-chloralose or pentobarbitone anaesthesia and the acoustic influence persisted after midcollicular decerebration. When added to other evidence, the above findings suggest that the reticular formation of the brain stem plays an important role in these polysensory interactions.


Responses in the rat thalamus to whisker movements produced by motor nerve stimulation. 1. The effect of electrical stimulation of the motor nerve supplying the whiskers on the activity of single cells in the vibrissal region of the ventrobasal complex of the thalamus has been studied in rats under urethane anaesthesia.2. The stimulation caused protraction of the ipsilateral whiskers. 60% of the cells which fired to mechanical movements of the whiskers were found to respond to this electrical stimulus with 1-2 impulses at short latency (average 7.7 msec), provided the stimulus was sufficient to move the whiskers.3. When the moving whiskers hit a barrier, 92% of the cells responded to the stimulus. The most effective position of the barrier was in front of the whiskers, although other positions often produced a response as well. Static displacement of the whiskers, particularly in the forward direction, could abolish the response or increase its latency.4. The following-frequencies for these cells were 5-10 stimuli/sec. Combinations of electrical stimuli with mechanical ramp movements of the whiskers showed that similar recovery times followed both types of stimuli.5. These results are compared with those reported from studies in the afferent nerve fibres after electrical stimulation of the motor nerve and also with responses in the thalamus following mechanical movements of the whiskers. The possible importance of the latency of these sensory responses is considered.


The influence of centrally applied noradrenaline on shivering and body temperature in the pigeon. 1. Noradrenaline (NA) was injected in a volume of 1.0 mul. through chronically implanted cannula into the hypothalamus of the unanaesthetized pigeon.2. In doses of 1-15 mug NA caused complete inhibition of shivering of dose-dependent duration. Histological mapping of the brain showed that NA was exerting its inhibitor action in the region above the optic chiasma bordering on the posterior hypothalamus and the anterior preoptic nucleus.3. At low ambient temperature, the NA induced inhibition of the cold tremor caused a fall of core temperature which lasted as long as shivering was inhibited. Shivering induced by local cooling of the spinal cord, and by the combined cooling of the skin and the spinal cord, was likewise inhibited by the cerebral application of NA. There was no evidence of an adjustment of the temperature set-point by NA.4. A rapid rise in skin temperature of the unfeathered feet, whenever NA was injected indicated a reduction in peripheral vasomotor tone.


Isolation of lymphocytes from peripheral blood of dogs.


A modified macro-method for the quantitation of the hemolytic activity of rabbit complement.


Quaternary structure of apoferritin: the rotation function at 9 A resolution.


Quantitative determination of conformations of flexible molecules in solution using lanthanide ions as nuclear magnetic resonance probes: application to adenosine-5'-monophosphate.


Interaction between the basic inhibitor of bovine pancreas and chymotrypsin and trypsin. Selective anthraniloylation of the maleylated inhibitor.


Letter: interpretation of intramolecular energy transfer experiments.


Estimation of the contribution of peripheral and central noradrenergic neurones to urinary 3-methoxy-4-hydroxyphenylglycol in the rat.


Ion fluxes through the sodium channels of garfish olfactory nerve membranes. 1. The efflux of (22)Na from garfish olfactory nerves, after treatment with ouabain and equilibration with (22)Na, occurs in two components of almost equal size. One component represents efflux from the extracellular space and the other, much slower, component represents efflux from the intracellular space through the axonal membrane.2. The rate of efflux of (22)Na through the membrane is increased from 0.038 to 0.055 min(-1) by veratrine, and restored back to 0.036 min(-1) by the additional application of tetrodotoxin or saxitoxin (10(-7)M).3. 50% inhibition of this increased sodium ion flux occurs at tetrodotoxin and saxitoxin concentrations of 12 and 6 nM respectively.4. The tetrodotoxin-sensitive efflux of (22)Na is almost unchanged in nerves equilibrated with hypertonic 0.85 M-NaCl, whereas it is largely eliminated in nerves equilibrated with 0.85 M-LiCl. We interpret this to indicate that there exists within the sodium channel a specific metal cation site which is responsible for the co-ordination of the ions during their passage through the membrane. Lithium ions bind to this site relatively strongly, with a dissociation constant of 0.2-0.3 M, whereas sodium ions bind less strongly, with a dissociation constant greater than 0.75 M. Other evidence indicates that this site is the site at which tetrodotoxin and saxitoxin act.5. Batrachotoxin has a similar action to veratrine but is effective in concentrations at least 100 times lower.


An estimate of sodium-potassium pump activity and the number of pump sites in the smooth muscle of the guinea-pig taenia coli, using (3H)ouabain. 1. Binding of tritiated ouabain to the smooth muscle of the guinea-pig taenia coli showed two components, one saturable at lower glycoside concentrations and the other linear with increasing concentrations.2. The saturable component alone was affected by extracellular potassium concentrations. This component seems to be bound to sodium pumping sites, and when completely saturated binds 1.1 x 10(11) molecules per mg fresh wt. of tissue, or 250-300 molecules per square micron of membrane, assuming a volume:surface area ratio of 1.5 mum.3. Only a fraction of (42)K uptake by the cells can be blocked by ouabain at maximal concentrations. In normal Krebs solution two thirds can be blocked. The remaining one third is presumably passive uptake. The fraction blocked is reduced as the extracellular potassium concentration, and thus passive uptake, is increased.4. The amount of potassium pumped into the cells at various concentrations of extracellular potassium has been calculated. In normal Krebs solution the amount pumped in 45 min was 20.0 m-mole/kg fresh wt., and this was increased at higher potassium concentrations.5. On the assumption of a stoichiometry of 3Na: 2K, the pump sites in normal Krebs solution have a turnover rate of 1320 min(-1).6. Indirect calculations of sodium movements suggest that the sodium permeability may be about 0.9 x 10(-8) cm sec(-1) and the pump may generate a current of 0.9 x 10(-7) A cm(-2). This crossing an Ohmic membrane resistance of 30-60 kOmega cm(2) would be equivalent to a potential difference of 3-5 mV.


Effects of rapid cooling on the electrical properties of the smooth muscle of the guinea-pig urinary bladder. The effects of low temperature (36-10 degrees C) on the electrical properties of smooth muscle cells of the urinary bladder were investigated with microelectrodes and the double sucrose gap method.1. Lowering the temperature from 36 to 20 and to 10 degrees C, depolarized the membrane from -37 to -33 and to -25 mV respectively. Spontaneous and propagated spike activity ceased completely at below 20 degrees C but evoked spikes were occasionally observed at 10 degrees C. A sustained contracture was evoked below 25 degrees C.2. At both normal and low temperatures, the tissue had cable-like properties. The length constant was reduced from 1.82 mm (36 degrees C) to 1.54 mm (20 degrees C) and to 1.04 mm (10 degrees C). On the other hand, the time constant of the membrane calculated from the cable equations was prolonged by lowering the temperature from 157 msec (36 degrees C) to 257 msec (20 degrees C) and to 508 msec (10 degrees C). The effective resistance of the membrane was increased to 1.8 times at 20 degrees C and to 2.9 times the control value at 10 degrees C.3. From the changes in various parameters of the membrane at low temperature, an increase in the longitudinal resistance of the tissue was postulated.4. The possible mechanisms of action of low temperature on the electrical properties of the smooth muscle of the urinary bladder were discussed in relation to those of the taenia coli and stomach, especially on the effects of low temperature on the sequestered Ca in the cell.


A comparative study of the deformations of intact and pathologic articular cartilage under mechanical stress.


Microspectrophotometric evaluation of oxidative enzymes in epithelial wound healing.


Epidermodysplasia verruciformis. 3. Ultraviolet micro-irradiation of cells in culture.


Editorial: Medical school places in Britain.


Determination of the migration area in macrophage migration inhibition assay: a comparison of the whole with the dense part of the fan.


A study of cellular inflammatory reaction in human malignant melanoma, using in vitro-labelling techniques with h3-thymidine.


A survey of characteristics of optometric prescribing.


Early diagnosis of the Zollinger-Ellison syndrome.


Reye's syndrome.

Reye's syndrome.


Removal of "lost" intravascular catheters.


Medical grand rounds from Touro Infirmary: multiple myeloma.


Editorial: Nurse Practice Act.

Editorial: Nurse Practice Act.


A fluorometric method for the determination of residues of 1-naphthaleneacetamide and 1-naphthaleneacetic acid on apples.


The need for rapid assays of protein quality.


Identification of scopoletin in dried bract of the cotton plant.


Fate of neodecanoic acid in onion and soil.


A method for determination of vicine in plant material and in blood.


Chlorogenic acid-protein interactions in sunflower.


Persistence and metabolism of thiophanate-methyl in soil.


Purification and some properties of miraculin, a glycoprotein from Synsepalum dulcificum which provokes sweetness and blocks sourness.


Phenolic constituents in sunflower flour.


Metabolism of the herbicide pronamide in soil.


Metabolism of carbofuran in mugho pine.

Metabolism of carbofuran in mugho pine.


Consumption and fate of aflatoxin B1 by lactating cows.


Metabolic transformations of disugran by rumen fluid of sheep maintained on dissimilar diets.


Electrophoretic observations on protein changes and variability during development of the peanut.


Photochemistry of N-sec-butyl-4-tert-butyl-2,6-dinitroaniline.


Production of 3-(1,2-epoxypropyl)-5,6-dihydro-5-hydroxy-6-methylpyran-2-one by Aspergillus ochraceus Wilhelm.


Accumulation, distribution, and excretion of mirex-14C in animals exposed for long periods to the insecticide in the diet.


Chemical and metabolic characteristics of 1-naphthyl-beta-D-glucoside.


Effects of pesticides on active transport of glucose through the isolated intestine of the mouse.


Residues of dimethoate and its oxygen analog on and in citrus leaves following a helicopter treatment of the trees with dimethoate ultra-low volume concentrate and high volume spray.


Photoreduction of Mirex in aliphatic amines.


Penicillamine for rheumatoid arthritis.

Penicillamine for rheumatoid arthritis.


Observations on the personality of the obesity patient.


Effect of vascular implantation on experimental renovascular hypertension: a comparison of two techniques.


Dean comments on issues in retention of Michigan medical graduates.


Intrahepatic cholestasis in hyperemesis gravidarum: a case report.


Embryonic lung epithelial-mesenchymal interactions during the process of carcinogenesis. I. Effect of carcinogenic hydrocarbons.


A mass acute poisoning resembling chlorinated insecticides poisoning but with unknown source.


Esophageal atresia.

Esophageal atresia.


The cyclic motility of the omasum and its control in sheep. 1. The mechanical activity of different parts of the omasum was recorded by means of small balloons and/or strain-gauges in conscious sheep. These events were related to the electrical activity of the omasal body, the omasal groove and the leaves and to the changes in diameter of the reticulo-omasal orifice. Humoral, behavioural and nervous influences were examined.2. Two patterns of contraction of the omasum were found. One, confined to the oral and middle thirds of the organ, originated at the omasal groove and proceeded to the right and then the left surfaces of the body and ceased at the onset of reticular contraction. The other was limited to the aboral third of the organ near the abomasum; in this part the contractions were prolonged regardless of the reticular contraction and some gave rise to a reversed propagation over the organ. The characteristic cyclic motility of the omasum was slightly reduced in sheep fasted for 48 hr and in those fed on pelleted food, and it persisted after vagotomy.3. The reticulo-omasal orifice always dilated strongly during the second phase of reticular contraction. It also dilated noticeably during the extra-contraction associated with regurgitation. In each case alternating opening and closing movements at a frequency of 5-7/min followed. Contractions of the omasal leaves, which were independent of those of the omasal body, occurred at a rate of approximately 2-3/min. They passed from the free border to the base and travelled in an aboral direction. After local application of fatty acids the frequency of their contractions increased to approximately the same rate as that of the orifice.4. It is concluded that the motility of the omasum in sheep involves a wave of contraction starting at a point on the omasal groove just posterior to the reticulo-omasal orifice and passing slowly over the omasal body. With the exception of the occasional reversed contractions this pattern is closely associated with rumino-reticular cycles even though the omasal contractions and the movements of the leaves are partially independent of vagal innervation.


Relationships between motor nerve conduction velocities and motor unit contraction characteristics in a slow twitch muscle of the cat. 1. Isometric contractions of cat soleus muscles and of functionally isolated motor units have been measured under conditions similar to those of Bagust, Knott, Lewis, Luck & Westerman (1973).2. The muscle lengths at which motor unit twitch and tetanus tensions were maximal were close to the optimal lengths of the parent muscles.3. Motor unit contraction times and tensions were shown to be related to the conduction velocities of the nerve axons supplying them. These relationships were obscured when a number of small samples from several experiments were grouped together.4. The ratios of the twitch to the tetanic tensions of the motor units were directly related to their times to peak tension.


Flagyl (metronidazole) in the treatment of intestinal amoebiasis. (Part one).


Prosthogonimus Sp. in an infant.

Prosthogonimus Sp. in an infant.


Localization of non-immune radioactively labelled cells in the lesions of contact sensitivity in mice.


The interpretation of paradoxical radioimmunoassay standard curves.


Photo-induced joining of a transfer RNA with its cognate aminoacyl-transfer RNA synthetase.


Cytoplasmic ribonucleic acids with messenger characteristics in salivary gland cells of Chironomus tentans.


Structure of horse muscle phosphoglycerate kinase. Some results on the chain conformation, substrate binding and evolution of the molecule from a 3 angstrom Fourier map.


Alcohol--a report on a study in Dublin post-primary schoolchildren, 1970.


The management of transverse and oblique lie.


Review of total hip replacement Charnley type.


A wave of the lamp.

A wave of the lamp.


Infants of diabetic mothers.

Infants of diabetic mothers.


Some properties of phototransformation of rye phytochrome in vitro.


A comparison of oxytetracycline with doxycycline in the winter chemoprophylaxis of chronic bronchitis.


The displaced lens.

The displaced lens.


Doxorubicin in combination chemotherapy for breast cancer: a preliminary report.


Two congenital cystic malformations.

Two congenital cystic malformations.


Potassium-induced bowel ulceration.

Potassium-induced bowel ulceration.


Morphology and development of Termitaria snyderi.


Effect of temperature on growth rate of seven thermophilic fungi.


Multivariate vectorial analysis of the visual evoked response.


An application of the cross-correlation coefficient to pattern recognition of honey bees.


Some measures of information arising in statistical games.


Classification of mental illness: the value of certain French nosological concepts.


Differential diagnosis of schizophrenic and nonschizophrenic adolescents by tests based on interference theory.


Notes on five years of office consultations in psychiatry.


Mourning and depression: their similarities and differences.


Respiratory relief treatment of a case of phobia with spasmodic torticollis.


Letter: Christ and psychiatry.

Letter: Christ and psychiatry.


Letter: Is oxytocin an anti-schizophrenic hormone?


Amino acid sequence determination with radioactive proteins.


Cation complexation by valinomycin- and nigericin-type inophores registered by the fluorescence signal of Tl+.


Effect of insulin and denervation on the activity of ribosomes of rat diaphragm muscle.


Structure of 11S acetylcholinesterase. Subunit composition.


A kinetic investigation of the interaction of serine transhydroxymethylase with glycine and serine.


Isolation and characterization of porcine pancreatic kallikrein.


Kinetic activation volumes of the binding of oxygen and carbon monoxide to hemoglobin and myoglobin studied on a high-pressure laser flash photolysis apparatus.


The acidic transition of delta-chymotrypsin.


Notable diversity in peptide composition of murine H-2K and H-2D alloantigens.


A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein.


Biosynthesis of hydroxyfatty acid polymers. Enzymatic synthesis of cutin from monomer acids by cell-free preparations from the epidermis of Vicia faba leaves.


Kinetics of transamidating enzymes. Production of thiol in the reactions of thiol esters with fibrinoligase.


Flavine-protein interactions in flavoenzymes. Effects of aggregation of the apoprotein of Azotobacter flavodoxin on coenzyme binding.


A hydrogen-exchange study of lysozyme conformation changes induced by inhibitor binding.


Fluorine nuclear magnetic resonance studies of trifluoroacetyl-insulin derivatives. Effects of pH on conformation and aggregation.


Electron microscopy and physical parameters of human blood group i, A, B, and H antigens.


Role of base composition in the electrophoresis of heat-treated deoxyribonucleic acid from HeLa and mouse cells in composite polyacrylamide gels.


Isozyme allelic frequencies related to selection and gene-flow hypotheses. Significant correlations between allelic frequencies and environmental variables in a number of insect species have been demonstrated by multivariate techniques. Since many environmental variables show a strong relationship to geographic location and since gene flow between populations can also produce patterns of gene frequencies which are related to the geographic location, both selection and gene-flow hypotheses are consistent with the observed correlations. The genetic variables can be corrected for geographic location and so for linear gene-flow patterns. If, after correction, the genetic variables still show significant correlations with similarly corrected environmental variables, then these correlations are consistent with hypotheses of selection but not of gene flow. The data of Johnson and Schaffer (1973) have been reanalyzed using the method of canonical correlation after correction for geographical location by means of multiple regression. Five of the nine loci studied exhibit significant canonical correlations. These results, under the assumption of linear gene flow, support hypotheses of selective action of environmental variables in the genotype-environment relationships observed.


The pertinence of the periodic selection phenomenon to prokaryote evolution. A quarter of a century ago, it was pointed out that evolution can act in an important conservative way, in addition to its normal progressive mode. Evolution to a fitter form via changes at one locus means that the descendants of an individual with an improved locus or set of loci will supplant the previous population and carry with them the bulk of the total genotype of that original individual in asexual populations. Inasmuch as that individual is most likely to be wild type at most other loci, neutral and even other positively selected mutations will be reduced or eliminated from the population, if they are rare at the time of the evolutionary advance. In the present paper this problem has been set up for a computer simulation. The computations show the limits within which this effect functions and the conditions under which it does not. The conclusion is that it is likely that evolution at a locus proceeds in the course of many population replacements or revolutions, mostly via the rare occasions when the revolution carries a previously infrequent mutational type into abundance.


X-linked mental retardation.

X-linked mental retardation.


Recurrent hemorrhage from a small aneurysm of the inferior gluteal artery.


Anomalous origin of the left circumflex coronary artery. Report of a case.


Muscle ribosomal protein synthesis in normal pregnancy: implication for carrier detection in Duchenne muscular dystrophy.


Cystathionase deficiency in fibroblast cultures from a patient with primary cystathioninuria.


Evidence for mutation being the source of the abnormal gene for plasma cholinesterase.


Correlation of B-scan ultrasonic laminography with bilateral selective hypogastric arteriography and lymphography in bladder tumors.


A genetic register system (RAPID).

A genetic register system (RAPID).


Vascular access for chronic hemodialysis.


Autosomal dominant pseudoxanthoma elasticum.


Evidence for autosomal recessive inheritance in cerebral gigantism.


Extensive cytological damage caused by measles in African children.


The significance of radiation-induced chromosome abnormalities in radiological protection.


Observations on human amniotic fluid cell strains in serial culture.


Deletion of the long arms of the Y chromosome with normal male development and intelligence.


Identification of the source of bleeding in multiple intracranial aneurysms.


Vibrations recorded from the adventitial surface of experimental aneurysms and arteriovenous fistulas.


Investigation of the portal circulation via the umbilical vein.


Cardiovascular technology: a model postgraduate training program.


Thermoluminescent dosimetry in the radiological sciences.


Employer-employee relations: unions and hospitals.


Do our students know enough mathematics? Results of a survey.


Beam divergence styrofoam block-cutting apparatus for mantle fields.


Surgical management of postgastrectomy syndrome.


Radiologic seminar CXXXXI: volvulus of the sigmoid colon.


Mississippi physicians' attitudes toward the Supreme Court abortion decision.


Community mental health centers--quantity or quality?


Essential hypertension: treatment of ambulatory patients.


Editorial: Informed consent--historic dilemma.


Malignant hypertension treated with modern antihypertensive drugs.


Editorial: TAP (Trustee-administration-physician).


Hypertension overview.

Hypertension overview.


Non-operative removal of retained biliary tract stones: combined percutaneous extraction and heparin flushing therapy.


Renting? Read this.

Renting? Read this.


Control of heart rate in atrial fibrillation.


Chemical burns.

Chemical burns.


Are abnormalities in insulin secretion responsible for reactive hypoglycemia?


Sex pheromones and reproductive isolation of the lesser peachtree borer and the peachtree borer. (E,Z)-3,13-octadecadien-1-ol acetate, and (Z,Z)-3,13-octadecadien-1-ol acetate, isolated from the female lesser peachtree borer, Synanthedon pictipes (Grote and Robinson), and the female peachtree borer, Sanninoidea exitiosa (Say), respectively, strongly attract the respective males of these species in field bioassays. These compounds are the largest pheromones isolated thus far from a lepidopterous species. Sanninoidea exitiosa males did not respond to the synthesized (E,Z)-isomer, and low concentrations of it in the synthesized (Z,Z)-isomer did not interfere with their response to the (Z,Z)-isomer. In contrast, even very low concentrations of the (Z,Z)-isomer (1 percent) in the (E,Z)-isomer significantly inhibited the response of Synanthedon pictipes males.


Beta-cell insulin secretory response to glucose in odd-carbon number fatty acid-enriched rats: preservation during starvation.


Letter: The tuned-receptor paradigm.

Letter: The tuned-receptor paradigm.


Detection of a gonadotropin in rabbit blastocyst before implantation. A gonadotropin similar to human chorionic gonadotropin or luteinizing hormone has been demonstrated in rabbit blastocyst prior to implantation. The gonadotropin has been detected by a radioreceptor assay for human chorionic gonadotropin with the use of the plasma membranes of bovine corpora lutea obtained during the first trimester of pregnancy. The concentrations of the human chorionic gonadotropin or luteinizing hormone per milliliter of blastocyst fluid were tenfold higher than those in the blood of pregnant rabbits on days 5 and 6 after mating.


Anemia in domestic cats: effect on hemoglobin components and whole blood oxygenation. Phenylhydrazine-induced anemia in the domestic cat results in an increase in minor, high oxygen affinity hemoglobin B components and an accompanying decrease in the major, low affinity B component. This change is accompanied by an unusually large increase in erythrocytic adenosine triphosphate and 2,3-diphosphoglycerate, a slight decrease in the oxygen affinity of whole blood, and a large decrease in the Hill constant.


Amphetamine effects in man: paradoxical drowsiness and lowered electrical brain acitivity (CNV). Thirteen of 20 normal adults given 10 milligrams of dextroamphetamine exhibited paradoxical drowsiness accompanied by lowered electrical brain activity (contingent negative variation, or CNV) in the first hour post-drug. During this period, seven subjects showed behavioral alertness and increased CNV amplitude. Both groups of subjects showed heightened alertness 2 and 3 hours post-drug. Amphetamine is not a simple stimulant of the central nervous system but can also act as a depressant.


Letter: Juvenile hormone synergists: a possible case of hasty conclusion?


The foam test as a prognosticator of fetal pulmonary maturity.


Hysterectomy and tubal ligation: a comparison of the psychological aftermath.


Estimation of the screening error rate from the observed detection rates in repeated cercival cytology.


Cellulose: its regeneration in the native lattice. The regeneration of cellulose from solutions in 85 percent phosphoric acid into glycerol at 170 degrees C resulted in its recovery wholly in the native or cellulose I lattice. Identification of the structure of the regenerated material is based on comparisons of its x-ray diffractogram and its Raman spectrum with those of the native fiber, cellulose II, and cellulose IV.


Toxic and antifertility effects of quinacrine hydrochloride in rats.


Mirex: an unrecognized contaminant of fishes from Lake Ontario. A perchlorinated, cage-structured hydrocarbon, C(10)C(l2), also known as mirex or Dechlorane, has been identified in fish samples from the Bay of Quinte, Lake Ontario, Canada. The compound coelutes with polychlorinated biphenyls (PCB's) in residue cleanup procedures and under standard gas chromatographic conditions. Mirex has never been registered for use as an insecticide in Canada, nor does it appear to be in use in any area of the United States discharging water into Lake Ontario or its tributaries. It seems likely, therefore, that this compound is another widespread environmental contaminant of extremely high geochemical stability and as yet only superficially investigated biological activities. Under standard gas chromatographic conditions its peak is superimposed on that of the PCB's, and, as a result, the presence of mirex may have been unrecognized and it may therefore have been misinterpreted as a PCB isomer.


Free radicals and inflammation: protection of synovial fluid by superoxide dismutase. Enzymatically genierated superoxide radical. by reactitng with hydrogen peroxide to prduce the hydroxyl radical, depolymerized puirified hyaluronic acid and bovine synovial flulid. Since phagocytizing polymorphonuclear leukocytes produce superoxide radicals, this reac-tion is sutggested and shown to be quantitatively feasible as the ini vivo mechanism of synovial fluid degradation in anl inflamed joint. Superoxide dismutase, and catalase protect synaovial fluid against such degradation in vitro.


Inhibition and reversal of capping by cytochalasin B, vinblastine and colchicine.


Inhibition of surface capping of macromolecules by local anaesthetics and tranquillisers.


Excess males among siblings of Australian antigen carriers.


Adenyl cyclase stimulation by aspirin in rat gastric mucosa.


Dynamics and function of vitamin A compounds in rat retina after a small bleach of rhodopsin.


Quantum conductance changes in lipid bilayer membranes associated with incorporation of acetylcholine receptors.


Opiate agonist-antagonist effects on Renshaw cells and spinal interneurones.


Lithium and the monoamine neurotransmitters in the rat hippocampus.


Pentamerism and the ancestral echinoderm.


Temperature effects on hearing in two species of Amphisbaenia.


Fertilisation of sheep ova following their transfer to goats.


Editorial: Abdominal incisional hernia--the role of wound infection.


Flexor digitorum sublimis to profundus tendon transfer for flexion deformities in spastic paralysis.


Letter: Cholecystectomy.

Letter: Cholecystectomy.


Barley stripe mosaic virus in sperm and vegetative cells of barley pollen.


Some properties of TYMV nucleoproteins isolated in cesium chloride density gradients.


Characterization of bacteriophage T4 DNA on the basis of an asymmetric distribution of (G plus C)-rich and (A plus T)-rich segments and their bearing on early and late mRNA transcription.


Lysogenization and curing by int-constitutive mutants of phage lambda.


The viral DNA replication complex of adenovirus 12.


Macromolecular synthesis in cells infected by frog virus 3. II. Evidence for post-transcriptional control of a viral structural protein.


Acquisition factor required for aphid transmission of purified cauliflower mosaic virus.


Co-electrophoresis of dsRNA from wound tumor and rice dwarf viruses.


Metastatic incidence of a spontaneous murine mammary adenocarcinoma.


Proceedings: Third Conference of Embryonic and Fetal Antigens in Cancer. Introduction.


Composition of the amniotic fluid and maternal serum in pregnancy.


Cervical perforation by the Copper T intrauterine contraceptive device.


Lysosomal enzymes of amniotic fluid in relation to gestational age.


Thyroxine-evoked precocious decrease of acid hydrolases in the ileum of suckling rats.


Letter: Familial hyperthecosis.

Letter: Familial hyperthecosis.


I. Drug sensitivity of rat adjuvant arthritis, induced with "adjuvants" containing no mineral oil components.


Affinity chromatography of renin using inhibitory renin substrate analogs.


Activity and extractability of lysyl oxidase and collagen proteins in developing granuloma tissue.


Plasma levels of hemopexin and albumin in disorders of porphyrin metabolism.


Effects of age on growth and food efficiency response in rats infected with tapeworm larvae.


Catecholamine content and response to norepinephrine of middle cerebral artery.


Inhibition of induced ovulation by a highly purified extract of the bovine pineal gland.


Abnormal platelet response to thromboplastin infusion in rabbits deficient in the sixth component of complement.


Delivery of vitamin B12 to human lymphocytes by transcobalamins I, II and 3.


Effect of renal denervation and alpha-adrenergic blockade on sodium excretion in dogs with chronic ligation of the common bile duct.


Peripheral blood lymphocyte responses to phytohemagglutinin and pokeweed mitogen during pregnancy.


The action of ouabain on the smooth muscle cells of the rat tail artery.


Lysosomal enzyme release: a possible mechanism of action of cobalt as an erythropoietic stimulant.


Subcellular ionic distribution in liver and heart tissues of cold-acclimated rats.


Choline phosphotransferase and phosphatidyl ethanolamine methyltransferase activities in spleen microsomes of mice infected with Friend virus.


Bromodeoxyuridine-inhibition of substratum-controlled chondrogenesis.


Reduction of serum prolactin in rats by 2 ergot alkaloids and 2 ergoline derivatives: a comparison.


Vascular waterfall phenomenon in the bovine.


Acute renal failure: structural-functional correlation.


Potentiation of gentamicin nephrotoxicity by metabolic acidosis.


Uptake of protein bound vitamin B12 by canine organs.


The influence of glucocorticoids on plasma cholinesterase.


Seromucoid and albumin syntheses after uninephrectomy and partial hepatectomy in the rat.


Parathyroid hormone and liver regeneration.


Specificity of the renal transport impairment in chickens having hyperuricemia and articular gout.


Renal response to sodium restriction in myxedema.


Protein and glycoprotein synthesis by isolated kidney glomeruli.


Use of phentolamine in acute myocardial infarction.


A natural history study of the prognostic role of coronary arteriography.


Diagnostic value of Q-waves in inferior myocardial infarction.


Effects of human contact on the heart activity of curarized patients in a shock-trauma unit.


Conduction defects in experimental atrial arrhythmia.


Effects of hemodialysis-induced hypokalemia and hypomagnesemia on blood pressure in dogs.


Direct arterial pressure, pulse rate, and electrocardiogram during micturition and defecation in unrestricted man.


Myocardial infarction without obstructive coronary artery disease.


Relationship between regional ventricular asynergy and the anatomic lesion in coronary artery disease.


Noninvasive preoperative diagnosis of cor triatriatum with ultrasonocardiotomogram and conventional echocardiogram.


Editorial: The significance of food poisoning in Canada.


A new bedside radioisotope test for the detection of deep-vein thrombosis.


Myocardial infarction after propranolol withdrawal.


The senile kidney.

The senile kidney.


Letter: Specificity of early systolic notch.


Letter: Effect of lidocaine on "gating" mechanism.


Letter: Onchocerciasis in Canada.

Letter: Onchocerciasis in Canada.


Editorial: Cardiorespiratory fitness.

Editorial: Cardiorespiratory fitness.


Letter: Fasting blood sugar.

Letter: Fasting blood sugar.


Letter: Postgraduate training in the Caribbean.


Letter: Painless weight loss.

Letter: Painless weight loss.


Letter:The Royal College.

Letter:The Royal College.


Letter: Rigors following methicillin administration.


A current view of Canadian cardiorespiratory fitness. A standard Astrand bicycle ergometer test was used to predict the maximum oxygen intake of 672 female and 558 male volunteers ranging in age from 15 to 69 years. In terms of this index of cardiorespiratory performance Canadians were unfit relative to Swedish norms. Also, some 47% of women and 40% of men achieved only low or fair fitness categories when evaluated relative to American Heart Association recommendations. These results are poorer than those reported for Torontonians in 1966. Men perceive their cardiorespiratory fitness accurately but women do not. In both sexes adequate recreational activity apparently leads to maintenance of cardiorespiratory fitness.


Blood fluorocarbon levels following exposure to household aerosols. Measurement of blood fluorocarbon levels was carried out in subjects exposed to a number of household aerosol products containing fluorocarbon gases as propellants. All aerosols were used according to manufacturers' recommendations. The general purpose of the study was to determine whether with normal routine exposure to a wide variety of household aerosol products fluorocarbon could be found in the blood and if so, to check the potential toxicity of the levels reached. Daily exposure to aerosols according to the study regimen lasted four consecutive weeks; this period was preceded and followed by two weeks of abstention from exposure. At the end of each of the three periods a medical examination, including evaluation of cardiac function, respiratory function studies, and hematological and functional clinical biochemical tests was performed. All tests and assessments failed to show any indication of toxicity. No trace of fluorocarbon was found in any of the blood sampled at intervals during the study.


Anterior approach to the cervical spine. The anterior approach to surgical treatment of disorders of the cervical spine is described, and the technique and advantages are outlined. A series of 66 patients who underwent 75 procedures is reported. The follow-up period ranged from one to five years. Good to excellent results were obtained with 91% of the operations for disc disease, and good results in all cases of fracture-dislocation. Adequate relief of pain was obtained with anterolateral cordotomy in two patients with malignant disease. Only minor complications were encountered; these were easily corrected or cleared up spontaneously. This approach is recommended in preference to the posterior approach for disc disease and fracture-dislocations of the cervical spine.


Medical research policy for Canada. II. Will the Medical Research Council survive new organizational proposals?


Consumer viewpoint. Thoughts on doctor-patient communication.


Medico-legal affairs: Circulatory complications after treatment of a fracture.


Effects of obstruction of the mitral orifice or distention of the pulmonary vein--atrial junctions on renal and hind-limb vascular resistance in the dog.


Surgical closure of atrial septal defects. Results of the circumclusion technique.


Importance of atrial compliance in cardiac performance.


Disposable filter for microemboli in cardiopulmonary bypass. Clinical and histological findings.


Effects of left ventricular function in patients with acquired cardiac valvular diseases on postoperative course of prosthetic valvular replacement.


Occlusion of renal and visceral arteries following blunt abdominal trauma: angiographic observations.


Protective action of methylprednisolone on the myocardium during experimental myocardial ischemia in the cat.


Instantaneous pressure-volume relationships and their ratio in the excised, supported canine left ventricle.


Some principles of medication in geriatrics.


Pharmacodynamic principles of drug therapy in the aged.


XI International Congress of the International Cardiovascular Society. Report of the Secretary General.


Perspectives for psychopharmacologic research in gerontology.


The day hospital: an alternative to institutional care.


Advanced occlusive arterial disease (gangrene) in the aged, and decision-making for amputation.


Lupus hair.

Lupus hair.


Femoro-pudendal by-pass in the treatment of sexual impotence.


Supravalvular aortic stenosis associated with aplasia of the left carotid artery: a case report.


Scar carcinoma of the lung. Fact or fantasy?


Cardiac performance in infants after repair of total anomalous pulmonary venous connection.


Report of the Ad Hoc Committee for Goals and Directions of the Southern Thoracic Surgical Association.


Supravalvular tricuspid stenosis resulting from persistent right sinus venosus valve. A report of successful correction.


Double aortic arch. Resection of aneurysm of left aortic arch in a 64-year-old man.


Communication of laboratory data to the clinician.


The relationship of College of American Pathologists Clinical Standard Solutions to National Bureau of Standards Standard Reference Materials.


The size and the source of analytic error in clinical chemistry.


An evaluation of clinical laboratory performance of pH-blood gas analyses using whole-blood tonometer specimens.


Performance of "kits" used for the clinical chemical analysis of salicylates in serum.


The 1972 nuclear medicine survey. Radionuclide identification and activity measurement.


Evaluation of the haema-count MK-3 blood counting system.


The clinical usefulness of segmented vs. stab neutrophil criteria for differential leukocyte counts.


Parasitology proficiency testing in the Quality Evaluation Programs of the College of American Pathologists.


Medium chain triglycerides and hepatic encephalopathy. The oral administration of short (C(6)) and medium (C(8) and (C(10)) chain triglycerides produced no clinical or electroencephalographic changes in patients with cirrhosis of the liver. Arterial ammonia levels were also monitored in these patients and showed no significant change after medium chain triglycerides. It was concluded that medium chain triglycerides, known to be of potential value in the treatment of malabsorption in patients with cirrhosis, are not clinically contraindicated, even in patients with evidence of hepatic encephalopathy.


Factors influencing duodenal trypsin levels following a standard test meal as a test of pancreatic function. In this investigation, the measurement of trypsin levels in duodenal juice following a standard test meal (Lundh test) was evaluated as a test of pancreatic function, and a study was made of diseases and other factors which may influence its diagnostic efficiency. The method of trypsin assay, which required only basic laboratory equipment, gave a linear concentration-activity curve, with a threshold at 50 mug of crystalline trypsin per ml. Intestinal juice could be frozen and stored for up to six weeks with no detectable loss of tryptic activity. The normal control values were very similar to those found by other workers and were unaffected by the sex or age of the subject. When used to assess 32 patients in whom the presence or absence of pancreatic disease had been clearly established, the test had a diagnostic success rate of 94%. Retrospective analysis of results from 98 patients showed that trypsin levels were generally grossly reduced in patients with chronic pancreatitis or carcinoma of the head of the pancreas. Trypsin levels were normal in most patients with steatorrhoea not of pancreatic origin. Levels were generally depressed to intermediate levels in patients with a diabetic glucose tolerance, with or without steatorrhoea, but no other sign of pancreatic insufficiency. Some lowering of trypsin levels was also noted in patients having an obstruction of the common bile duct. A small but significant depression of tryptic activity was noted in patients with villous atrophy and no pancreatic disease.


The dumping syndrome and the hydrogen ion concentration of the gastric contents. Forty patients after vagotomy (truncal vagotomy 18, selective vagotomy 22) with a drainage procedure were given 200 ml of 50% dextrose by mouth (dumping provocation test), the symptoms induced being noted, and any fall in plasma volume was assessed by serial measurement of the haematocrit. An insulin gastric secretion test was also performed on each patient.TWENTY OF THE PATIENTS HAD DUMPING SYMPTOMS OF VARYING SEVERITY AFTER ORDINARY MEALS: in all 20 patients these symptoms were reproduced by the dumping provocation test, which also produced similar symptoms in a further three patients. The hydrogen ion concentration of the gastric contents was significantly lower in the basal state and after insulin hypoglycaemia in those patients with dumping symptoms than in those without such symptoms. Furthermore there was a significant inverse correlation between the hydrogen ion concentration of the gastric contents in the basal and stimulated state and the rate of plasma volume fall. The results show that the occurrence of the dumping syndrome after vagotomy with a drainage procedure is related to the hydrogen ion concentration of the gastric contents. The possible significance of this finding is discussed.


Intestinal streaming patterns in cholerrhoeic enteropathy and diverticular disease. Streaming of gastrointestinal contents depends on the demonstration of differential rates of recovery of equal doses of two synchronously fed markers. There was no significant difference in the rate of throughput of polyethylene glycol (a liquid phase marker) and chromium sesquioxide (a solid phase marker) in healthy volunteers (n = 7) and hospital inpatients (n = 5) with normal bowel habit, so that streaming does not usually occur. In cholerrhoeic enteropathy (n = 5), however, the rate of throughput of polyethylene glycol was increased. In colonic diverticular disease (n = 7) the rate of throughput of polyethylene glycol was significantly lower. In cholerrhoeic enteropathy the liquid phase marker was excreted 1.5 times faster than the solid phase, but in the diverticular disease group the liquid phase was excreted 0.75 times more slowly than the solid phase marker. This may reflect the effects of colonic hypersegmentation on the relative distribution of the liquid and solid phases.


A method for rapid placing of small intestinal perfusion tubes.


Editorial: A new inborn error of metabolism.


The immune competence of patients with inflammatory bowel disease. Previous investigations of immune function in patients with Crohn's disease have yielded conflicting results. A comprehensive study of immune competence-peripheral lymphocyte count, serum immunoglobulin levels (IgG, IgA and IgM), lymphocyte response to PHA, Mantoux test, and DNCB response-has been performed in a large number of patients with inflammatory bowel disease. A total of 52 patients with Crohn's disease, 20 patients with ulcerative colitis, and 46 control patients with benign gastrointestinal disease were investigated. The patient groups were subdivided into ;well' and ;ill' in view of the differing clinical states of patients with inflammatory bowel disease. Some of the Crohn's and colitis patients were receiving steroid therapy. The peripheral blood lymphocyte count and lymphocyte response to PHA were similar in all patient groups. Serum IgA levels were elevated in Crohn's disease but fell significantly in ;ill' Crohn's patients following excisional surgery. Serum IgM levels rose significantly in ;ill' Crohn's patients after surgery. Steroid therapy was associated with diminution of both Mantoux and DNCB responses in the ;ill' Crohn's patients. There was no evidence of impairment of immune competence in either Crohn's disease or ulcerative colitis.


Closed-angle glaucoma. Theoretical considerations.


Precipitation of angle closure.

Precipitation of angle closure.


Gyrate atrophy of the choroid and retina associated with hyperornithinaemia.


Inadequate diagnostic value of the water-drinking test.


Effect of carbon dioxide on the intraocular pressure in man during general anaesthesia.


A suicide prediction schedule for neuropsychiatric hospital patients.


Parenteral interactions at various levels.


Social network correlates of avowed happiness.


Psychiatric illness--marital units and divorce.


Differences in family characteristics of heroin injectors and inhalers.


Self-administration of medication by psychiatric inpatients.


Editorial: Controlling coronary heart disease.


Editorial: Septal and associated cranial birth deformities.


Editorial: Care for the aged: who needs help?


Vesicoureteral reflux in childhood.

Vesicoureteral reflux in childhood.


Ketotic hypoglycaemia due to hypoalaninaemia.


Letter: Psychosurgery reconsidered--again.


Letter: Epidemic vertigo.

Letter: Epidemic vertigo.


Letter: Unexpected sudden death in infancy (cot death).


Letter: Effect of Bisolvon on sinusitis: a case history.


Letter: Hypotension.

Letter: Hypotension.


Letter: Immunization of migrant children.


Letter: Community health centre evaluation.


Interaction of chloroquine and carrageenan.


Effect of temperature on the binding of salicylate by human serum albumin.


A double-blind comparative clinical trial of cephalexin and ampicillin in the treatment of childhood acute otitis media.


Preliminary experience with a new low-oestrogen content combined oral contraceptive.


Action of cyclandelate on the development of collateral vessels in the rabbit.


Multi-centre general practitioner trial of isoxsuprine in peripheral vascular disease.


A comparative trial of lorazepam and doxepin in the treatment of anxiety.


A definitive second order factor analysis of the personality structure in high school age children.


An examination of creativity and locus of control in children.


Self-perceptions of scholastic ability at four grade levels.


A note on stress and sex determination.

A note on stress and sex determination.


Social desirability and delinquent behavior in adolescent females.


Conditioned after-images. I.

Conditioned after-images. I.


Learning and the spiral illusion.

Learning and the spiral illusion.


The regression to right angles tendency and the Poggendorff illusion. 3.


Tactile short-term memory by blind and sighted children.


Hemisphere function and paired-associate learning.


Handedness and musical ability.

Handedness and musical ability.


Hypnotic susceptibility and personality: a replication study.


Frustration and elation effects in operant analogues of the double runway.


Simultaneous discriminations: two separate types of control.


Strength of auditory stimulus-response compatibility as a function of task complexity.


Relation between similarity grouping and peripheral discriminability.


Role perception in stuttering.

Role perception in stuttering.


Stuttering and assertion training.

Stuttering and assertion training.


Auditory assembly of CVCs dy children with normal and defective articulation.


The naming and recognition of written symbols in aphasic and alexic patients.


Perceptual and acoustic correlates of aging in the speech of males.


Pyruvate kinase catalyzed phosphorylation of glycolate.


Inhibition of muscle pyruvate dehydrogenase by a polypeptide from growth hormone.


Human erythrocyte membrane sialoglycoproteins: a study of interconversion.


Multiple retinol binding proteins in rabbit lung.


The chemical synthesis of dinitrophenyl derivatives of serine and ethanolamine.


Sickness absence: facts and misconceptions.


Hydroxylation of taurolithocholate by isolated human liver microsomes. II. Cytochrome P-450 dependency.


Hormones in urine: uses and misuses.

Hormones in urine: uses and misuses.


Age-dependent induction and repression of rat liver microsomal hydroxylase systems by estradiol.


Serum-induced inhibition of isotonic fluid absorption by the kidney proximal tubule. II. Evidence that complement is involved.


Acetyl-CoA: 1,4-diaminobutane N-acetyltransferase. Occurrence in vertebrate organs and subcellular localization.


The timecourse of collagen cross-linking.


Contraction of experimental wounds. I. Inhibiting wound contraction by using a topical smooth muscle antagonist.


Distinction of allogeneic immunity from tumor-specific immunity in man.


Immune cytolysis of human tumor cells mediated by xenogeneic "immune" RNA: implications for immunotherapy.


Immune surveillance and tumor dissemination: in vitro comparison of the B16 melanoma in primary and metastatic form.


Airway resistance regulation of dynamic compliance.


The training of surgeons: how many, in what, and by whom?


Tropical medicine: trends and progress.

Tropical medicine: trends and progress.


Regional development of medical resources in South East Asia.


Economic development in the Third World: some implications for health.


Tropical medicine and industrial development.


Family health--a challenge to tropical medicine.


The health services impact of development projects.


Present status of the global malaria eradication programme and prospects for the future.


Resurgence of malaria and its control.

Resurgence of malaria and its control.


Repeating sequences in aminoacyl-tRNA synthetases.


Is the cytoplasm a site of nuclear DNA synthesis?


Erythropoiesis in an avian thymus.

Erythropoiesis in an avian thymus.


Messenger and aminoacylation functions of brome mosaic virus RNA after chemical modification of 3' terminus.


Evidence of hydrophobic interaction in adhesion to tissue.


Bacteria can swim without rotating flagellar filaments.


Treehopper (Membracidae) alarm pheromones.


Two spot ladybirds as indicators of intense local air pollution.


Vasopressin-induced increase in renal lymph flow and natriuresis in dogs.


Cell sodium, potassium and water in uraemia and the effects of regular dialysis as studied in the leucocyte.


Sodium and potassium transport rates in normal human leucocytes in hypo-osmolal extracellular fluid.


Air embolism: fission of microbubbles upon collision in plasma.


Plasma tocopherol levels and the susceptibility of erythrocytes to Heinz body formation.


Post-heparin lipolytic activity and tissue lipoprotein lipase activity in the alloxan-diabetic rat.


The effects of drugs that cause neutropenia upon colony formation by bone marrow cells in semi-solid agar.


A gene controlling bell- and photically-induced ovulation in mice.


Mechanism of antifertility action of low doses of alpha-chlorohydrin in the male rat.


The effects of various androgens on peripheral structures in the castrated male rat.


Citrate formation from exogenous substrates by washed human spermatozoa.


Effect of alpha-chlorohydrin on the fertilizing ability of hamster epididymal spermatozoa.


Detection of 3alpha-, 3beta- and 17beta-hydroxy-5beta-steroid dehydrogenases in epididymal spermatozoa of Holstein bulls.


The passage of abnormal spermatozoa through the uterotubal junction of the mouse.


The effect of vitamin E and synthetic antioxidants on the growth in vitro of explanted rat embryos.


Sperm transport in the female rabbit: the effect of inseminate volume and sperm density.


The effects of bovine seminal plasma on the impedance change frequency and glycolysis of bovine epididymal spermatozoa.


Birth of lambs after culture of sheep ova in vitro for up to 6 days.


Changes in uterine and oviducal fluid proteins during early pregnancy in the golden hamster.


Cytochemical localization of adenyl cyclase in the rat uterus.


Inhibition of fertilization in vitro by treatment of rabbit spermatozoa with univalent isoantibody.


The use of a new long-acting testosterone ester for the activation of sexual behaviour in castrated rabbits.


Ovum transport through rabbit oviducts perfused with 6-hydroxydopamine.


Proceedings: Effects of different oral contraceptives (combined and 'mini' pill) on lipid metabolism.


Effects of alpha-chlorohydrin and gonadectomy on the adenohypophysial cells of male rats and gerbils. The cytological changes occurring in the gonadotropic cells of the anterior lobe of the pituitary in 30 male rats and 30 male gerbils after administration of alpha-chlorohydrin were compared with those occurring following bilateral  gonadectomy.  A decline in the weights of testes and accessory sex glands and inhibited spermatogenesis were noted in rats and gerbils following alpha-chlorohydrin administration.  Alpha-cholorohydrin changed the appearance of the delta-basilphils, cell cytoplasm showed fine granulation and vacuolization, and castration vacuoles appeared in many delta-basiphils of the anteroir lobe of the pituitary.  The compound brought about transient changes resembling those of castration in the anterior lobe of the pituitary of male rats and gerbils.  In gerbils, there was also a marked decrease in the number of acidophils.  The results show that alpha-chlorohydrin exerts its effects on androgen-dependent structures, e.g., seminal vesicles, ventral prostrate, epididymides, and perineal complex.


Proceedings: Correlation of various clinical parameters with glucose tolerance test in women using oral contraceptives. A study was carried out to determine whether oral contraceptives affect carbohydrate metabolism as assessed by glucose tolerance curves.  Glucose tolerance tests were carried out in seventy-six women.  The women were divided into two groups.  The first group constituted the control and the second group comprised women taking combination oral contraceptives.  The glucose tolerance curves were correlated with: (1) the duration of thereapy; (2) the family history of diabetes; (3) the obstetric history; (4) age: (5) weight gain; (6) parity; and (7) changes in blood pressure.  The combination type of oral contraceptives were observed to affect adversely the glucose tolerance test.  A significant correlation was recorded between the familial diabetic history, intake of combination contraceptives and abnormal glucose tolerance tests.  A history of birth of a large baby was found to be an important indicator of abnormal values of glucose tolerance in women taking a combination type of oral contraceptive.  Such women showed an abnormal curve pattern at a much earlier age in life compared with controls.  It was also observed that a high percentage of women who had gained excessive weight on combination contraceptives had an altered glucose tolerance test.  Parity and blood pressure were two parameters which did not reveal any correlation with abnormal glucose tolerance curves.


Proceedings: Oestrogen-induced changes in the total lipid concentration in the immature and mature rat testis.


Proceedings: Steroidogenic cellular sites in the testis of the Indian skipper frog, Rana cyanophlyctis (schn).


Proceedings: Preliminary report on plasma human placental lactogen (HPL) levels during pregnancy and its biosynthesis in vitro in term placenta.


Proceedings: Biochemistry of the accessory sex gland complex in male cockroaches (Periplaneta americana).


Proceedings: Sialic acid in the different regions of the epididymis and ductus deferens of the albino rat.


Proceedings: Incorporation of L-(3H)arginine into proteins by the anterior pituitary and hypothalamus of intact and castrated male rats.


Proceedings: Action of chronically administered oestradiol on the uterus of the rat. Oestradiol induces increased synthesis of RNA and DNA in the uterus of ovariectomized rats.  The effects of continuously administered oestradiol on nucleotide synthesis in the uterus of the rats are reported.  Ovariectomized rats were given 2 Mug oestradiol-17 beta, subcutaneously, every 8 hr until autopsy at various times 1 to 7 days after the first injection of oestradiol.  (3H) uridine or (3H) thymidine was administered intraluminally 15 min before beath.  Uteri were processed for autoradiography.  The number of labelled cells and the average number of grains/cell were counted.  (3H) uridine labelling reached a peak at 6 to 54 hr and then decreased steadily thereafter.  DNA synthesis was maximal at 48 hr in all regions and minimal at 144 hr.  These results indicate that oestrogen caused maximum stimulation of RNA synthesis in the rat uterus at 30 and 48 hr respectively but activity was reduced thereafter.  The uterine epithelium and stroma were hypertrophied and hyperplastic when RNA and DNA synthesis were minimal.  This could be due to refractoriness of the specific target tissues to continued hormonal stimulation.


Proceedings: Effect of latex of Calatropis gigantea on pregnancy in the albino rat.


Proceedings: Effect of Hibiscus rosa sinensis on the reproductive organs of male rats.


Proceedings: Mode of action of a new non-steroidal, post-coital antifertility agent ('centchroman: 67-20 CDRI') in rats.


Proceedings: Ovarian development and fertility of mice neonatally treated with antiserum to ovine LH.


Proceedings: Hormonal control of the epididymis in the golden hamster.


Proceedings: Duration and dose effect of human chorionic gonadotrophin on the maintenance of pregnancy in adrenalectomized rats.


Proceedings: Humoral antibody formation during pregnancy.


Proceedings: Plasma progesterone levels during normal and abnormal pregnancy.


Proceedings: Evaluation of a new technique of vas deferens anastomosis.


Proceedings: The value of pelviscopy in the diagnosis of genital tuberculosis.


Proceedings: Increased androgen production following irradiation of oestrogen-treated mature male fish, Heteropneustes fossilis (Bloch).


Proceedings: Cultivation and maintenance of mammalian testis in organ culture.


Proceedings: Oestrogenic and antifertility effects of chalcone derivatives in the mouse.


Proceedings: Inheritance of an azoospermic condition in man.


Proceedings: Composition of the spermiducal secretion of the crab, Paratelphusa hydrodromous (Herbst).


Proceedings: Steroidogenic activity in the interrenal tissue of three Indian frogs.


Proceedings: Studies on the effect of Caulophyllum on implantation in rats.


Proceedings: Effect of oestrogen on nucleic acids and protein in the oviduct of immature and mature rats.


Proceedings: Oestrogen-induced changes in the total carbohydrate concentration in the testis.


Proceedings: Ovarian development in mice treated neonatally with progesterone and its effects on fertility. Administration of steroid hormones to rodents during the neonatal period results in an alteration of gonadal function and subsequent maturity.  These results have been reported in rats and mice treated neonatally with oestrogens or androgens (Kinml, 1970, 1971; Peters & Sorensen, 1970; Eshkol, Lunefeld & Peters, 1970).  In the present study, Swiss strain female mice were injected with a single dose of 1 mg progesterone at the age of 5 days and ovarian development was studied in the neonatal and the juvenile periods.  The treated mice were also observed for vaginal opening and subsequent fertility.  Histological studies revealed that the proliferation of the granulosa cells and antrum formation in the follicles of treated animals was affected, and the fertility of these mice was impaired.  Although the oestrous cycles were normal, sexual maturity (based on the age at which the first vaginal plug was seen) was delayed.  However, only 30% of the matings were fertile and fewer young were born than in the control group.  These results indicate, that, like other steroids, progesterone play a significant role in the neonatal development of the mouse ovary and the subsequent fertility of the animal.


Proceedings: Effect of cyproterone acetate on the epididymis and accessory glands of the rat. Cyproterone acetate, a well-known potent anto-androgen, competitively inhibits the action of endogenously and expgenously administered androgens on target organs like the epididymis and ventral prostate (Prasad, Rajalakshmi & Reddy, 1972).  Administration of cyproterone acetate to immature 30-day-old rats for 20 days or to adult, sexually mature rate for 15 days, resulted in a marked decrease in the content of sialic acid in the caput and cauda epididymides and a decrease in the  secretory activity of the dorsolateral prostate and coagulating glands.  The incorporation of (3H) uridine and (3H) phenylaline has been studied in adult rats treated with cyproterone acetate for 15 days.  An increased incorporation of (3H) uridine and (3H) phenylalinine was observed in the caput and cauda epididymidis cauda epididymidis followed by the caput epididymidis.  However, the increase in incorporation of (3H) phenylalanine was of the same order of magnitude in the caput and cauda epididymidis whereas it was almost insignificant in the ventral prostate.


Proceedings: Significance of seminal fructose studies in male infertility.


Absorption, translocation, and metabolism of metribuzin (BAY-94337) in sugarcane.


Environmental degradation of the insect growth regulator methoprene (isopropyl (2E,4E)-11-Methoxy-3,7,11-trimethyl-2,4-dodecadienoate). I. Metabolism by alfalfa and rice.


Fate of aldrin-14C in maize, wheat, and soils under outdoor conditions.


Carbofuran. Comparative toxicity and metabolism in the worms Lumbricus terrestris L. and Eisenia foetida S.


Breakdown of the herbicide dicamba and its degradation product 3,6-dichlorosalicylic acid in prairie soils.


Isolation of 2,2,5-endo,6-exo,8,9,10-heptachlorobornane and an octachloro toxicant from technical toxaphene.


Metabolism of chlordane in rats.

Metabolism of chlordane in rats.


Persistence of residues of velsicol VCS-506 and two of its metabolites in tomatoes and grapes.


Determination of sucrose, glucose, and fructose by liquid chromatography.


Improvement in the reproducibility of the enzymatic analysis of sucrose in stored Golden Delicious apples.


Purity of reagent grade p-and o-chlorophenoxyacetic acids and its biological implications.


Plasma estrone, estradiol, estriol, progesterone, and cortisol in normal labor.


Pregnancy following total hysterectomy.

Pregnancy following total hysterectomy.


Placental transfer of mercuric nitrate and methyl mercury in the rat.


Hyperextension of the head in breech presentation.


Treatment planning by computer.

Treatment planning by computer.


Oxygen uptake of nervous and muscular tissues from normal and renal hypertensive rats.


Squamous cell carcinoma of nasal vestibule.


Spontaneous subcutaneous emphysema of the head, neck, and mediastinum.


Versions of the CROS hearing aid.

Versions of the CROS hearing aid.


An objective assessment of a CROS hearing aid.


An optokinetic drum device.

An optokinetic drum device.


Fabrication of custom-made ear plugs for swimming.


Oropharyngeal inverted papilloma.

Oropharyngeal inverted papilloma.


Absorption of herbicides from the rat lung.


Ingested dyed cellulose in the blood and urine of man.


Optimal labelling conditions for thymidine incorporation in PHA- and PPD-stimulated human lymphocytes--effect of adherent cells.


Letter: Effect of aspirin on platelets from atopic subjects.


Long-term treatment of refractory sypraventricular tachycardia by patient-controlled inductive atrial pacing.


Heart size in older people.

Heart size in older people.


Systolic time intervals in coronary artery disease as indices of left ventricular function: fact or fancy?


Proceedings: Anomalous atrioventricular conduction associated with complete block of the nodal-His pathway: an electrocardiographic study.


Blood urea changes in hypertensive patients according to therapy given, blood pressure control, and serum potassium levels.


Proceedings: Doppler blood velocity studies in aortic stenosis.


Proceedings: Aortic blood velocity and flow measured by transcutaneous aortovelography.


Proceedings: Catheter for simultaneous measurement of aortic flow and left ventricular pressure.


Proceedings: Assessment of left ventricle performance in infants, children, and adults using single plane cine-angiocardiography.


Proceedings: Saphenous vein grafting of coronary arteries in patients with heart failure.


Proceedings: Fibrosis and the myocardium--study of their normal development and relation.


Proceedings: Stented tissue heart valve replacement.


Proceedings: A new development in ultrasound, using a multi-transducer technique.


Proceedings: Echocardiography in the evaluation of the newborn infant with cyanotic congenital heart disease.


Proceedings: Problems with total correction after aorta to right pulmonary artery anastomosis.


Proceedings: Influence of formulation on absorption and clinical effect of digoxin.


Proceedings: Is there a diuretic agent reflexly regulated by atrial receptors?


Proceedings: Significance of left ventricular dyskinesia at rest in patients with ischaemic heart diseases.


Crystalloid distribution following hemorrhage and hemodilution: mathematical model and prediction of optimum volumes for equilibration at normovolemia.


Carbenicillin indanyl sodium in the treatment of gonorrhoea.


Pulmonary arterio-venous fistula.

Pulmonary arterio-venous fistula.


Oxytocin stimulation and uterine rupture in the grand multipara.


A rapid and simple blood sugar determination using the Ames reflectance meter and Dextrostix system: a preliminary report.


Observations on anorectal suppuration.

Observations on anorectal suppuration.


Fractures of the shaft of the humerus. An analysis of 100 consecutive cases.


The operative treatment of fractures of the shaft of the humerus.


Repair of lesions to the flexor pollicis longus tendon. Methods and results.


The relationship of parents after the birth of a child with a congenital defect.


Vascular and nervous complications in injuries of the knee joint.


Guilt feelings in parents of children with congenital defects.


Spontaneous cervical epidural hematoma followed by disseminated intravascular coagulation.


Editorial: The criminal law.

Editorial: The criminal law.


Informed consent.

Informed consent.


Distribution of Mycobacterium ulcerans infections in Zaire, including the report of new foci.


Community-wide periodic anthelmintic treatment with levamisole.


Trichophyton rubrum and species of Candida in Thailand.


Early roentgen signs in aseptic necrosis of the hip secondary to steroid therapy.


Post-traumatic arterio-venous fistula of the extremities.


Abnormalities of myocardial depolarization in overt, subclinical and prediabetes. A vectorcardiographic study.


Effect of phenformin on glucose-insulin interrelationships.


Arene oxides: a new aspect of drug metabolism.


Immigration composition and population policy.


Chromosomes of the chocolate gourami: a cytogenetic anomaly. The chocolate gourami, Sphaerichthys osphromonoides, has the lowest chromosome number reported for fishes, with 2n = 16 and n = 8. Other members of the family Belontiidae have somatic numbers of 42 to 48. Chromosome instability is demonstrated by the presence of somatic abnormalities and meiotic multivalents.


Enduring learning deficits and cerebral synaptic malformation from exposure to 10 parts of halothane per million. Chronic exposure of rats to 10 parts of halothane per million during early life produced later deficits in learning a shock-motivated light-dark discrimination and a food-motivated maze pattern, correlated with enduring synaptic nembrane malformation in cerebral cortex. Adult exposure had no effect. Halothane may provide a useful analytical tool for study of brain. The behavioral-ultrastructural techniques also suggest a standard for assessing the safety of trace toxicants with central nervous system effects.


Editorial: Medical school admissions matching.


Foreign physicians: their impact on U.S. health care.


Lysosomal and microsomal glucuronidase: genetic variant alters electrophoretic mobility of both hydrolases. An electrophoretic variant of beta-glucuronidase is present in certain inbred mouse lines. The variant simultaneously affects the mobility of the lysosomal and microsomal forms of the enzyme. The difference is inherited as a single gene mapping at the position of the structural gene on chromosome 5. This confirms that beta-glucuronidase at both intracellular sites is coded by the same structural gene.


Letter: Stability of catecholamines immobilized on glass beads.


Physical fitness in pregnancy: its effect on pregnancy outcome.


Decidual changes during hypertonic saline-induced abortion.


Familial bicornuate and double uterus.

Familial bicornuate and double uterus.


Umbilical blood flow in late gestation: a comparison of simultaneous measurements with two different techniques.


Erythrocyte 2,3-diphosphoglycerate concentrations in umbilical venous blood from normal and meconium-stained neonates.


5-Hydroxyindoleacetic acid in the lumbar fluid: a specific indicator of spinal cord injury. In cats, 19 days after the lower thoracic cord was injllred, the concentrations of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid in the lumbosacral cord and that of 5-hydroxyindoleacetic acid in the lumbar fluid decreased. At the same time the concentrations of these substances in the cord above the lesion and that of 5-hydroxyindoleacetic acid in the cisternal fluid was not significantly altered. Since high concentrations of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid are present in the human lumbosacral cord, it appears that the concentration of 5-hydroxyincdoleacetic acid in the lumbar fluid of animals and man reflects the biochemical changes of 5-hydroxytryptamine in the spinal cord.


Chloral hydrate: a solvent for biological membranes. A buffer system conitainin chloral hydrate, taurine, and bromopyridinium lactate was used to dissolve several biological membranes and separate their protein components by polyacrylamide gel electrophoresis. This solvent system was capable of separating molecules of similar size on the hasis of their charge and allows easy recovery of the proteins Thus. aqueous chloral hydrate is an effective solvent for biological membranes.


Cerebral dominance in musicians and nonmusicians. Musically experienced listeners recognize simple melodies better in the right ear than the left, while the reverse is true for naive listeners. Hence, contrary to previous reports, music perception supports the hypothesis that the left hemisphere is dominant for analytic processing and the right hemisphere for holistic processing.


Competition: a theory based on realistic, general equations of population growth. Realistic equations of population growth, separately representing scarcity of renewed material resources and scarcity of fixed resources related to space, show the differential imnpact of these two factors on comnpetitive coexistence. The equations suggest a general theory of competition coverinlg any number or kinid of resolurces, consumers. and intraspecific and interspecific interactions.


Alpha- and beta-retinyl acetate reverse metaplasias of vitamin A deficiency in hamster trachea in organ culture.


Redistribution of endogenous gibberellins in geotropically stimulated roots.


Batesian mimicry without distastefulness?


Green cones of the piñon pine stimulate late summer breeding in the piñon jay.


Abdominal incisional hernias: a ten-year review.


Juvenile giant fibroadenoma of the breast.


Esophageal pressure studies in patients with carcinoma of the esophagus.


Osteoarthropathy associated with solitary pulmonary metastasis from melanoma.


Decreased red cell deformability in burn patients.


Comparative electrophoretic studies on the structural proteins of selected group A arboviruses.


The dipole moment in the lowest singlet pi formed from pi state of indole determined by the optical Stark effect.


Truncal vagotomy and mucosal pyloroplasty in the treatment of chronic duodenal ulceration.


Lupus nephropathy.

Lupus nephropathy.


Evidence for diploidy in Achlya bisexualis based on inheritance of cycloheximide resistance.


Sequential biosynthesis of ribonucleic acids during germination of teliospores of Ustilago maydis.


Beveling of fine micropipette electrodes by a rapid precision method. A technique has been developed for embedding alumina particles 0.05 micrometer in size in the surface of a polyurethane film laid on glass. This abrasive surface is used for rapid, precise, and reliable beveling of Pyrex micropipettes with tip diameters at least as small as 0.1 micrometer. In the snapping turtle retina the beveled electrodes give much better cell penetration and intracellular response stability than unbeveled electrodes of considerably higher proach to this problem.


Pulmonary-portal venous communication.

Pulmonary-portal venous communication.


Copper levels in women using intrauterine devices or oral contraceptives. A study was undertaken to explore the role of the copper IUD (Cu-200) in contraception and to lower its side effects.  Endometrial and plasma concentrations of copper were determined spectrographically in the late proliferative and late secretory phases in 15 women wearing the copper IUD, in 6 short-term Lippes loop users, in 23 long-term Lippes loop users,  in 17 patients on oral contraception, and in 32 women who were not using contraception,y The last group of women served as controls.  The findings showed a decrease in the endometrial copper level in the secretory phase but no change in the plasma concentration of copper in the control group.  Both Cu-200 and Lippes loops produced a rise in endometrial copper which was significant during the secretory phase.  The possibility of a local foreign body reaction is noted.  Combined steroid pills caused variable degrees of increase of endometrial and plasma copper in both phases.  Endometrial copper levels were elevated in both phases of the cycle, while plasma copper showed a probably significant rise in the proliferative phase only.  The change in plasma copper may be explained by changes occurring in hormonal pattern during pill therapy.


Biochemical studies of the testes and sex accessory organs of the desert gerbil after vasectomy.