Automated reaction rate analysis of erythrocyte glucose-6-phosphate dehydrogenase and glutathione reductase activities.


Affinity of myasthenia drugs to acetylcholinesterase and acetylcholine receptor.


On the structure of the hemoglobins A, A2, and F in a Negro with homozygous beta-thalassemia.


Levels of glutamate decarboxylase, choline acetyltransferase and acetylcholinesterase in identified motorneurons of the locust.


The cholinergic excitatory and inhibitory postsynaptic responses of Aplysia ganglion cells during and after lithium-Ringer perfusion.


Effect of lithium on neuron survival in cultures of dissociated human spinal ganglion cells.


Histofluorescence study of chromaffin cells in dissociated cell cultures of chick embryo sympathetic ganglia.


Metabolism of lactate isomers by rumen mucosa.


Extracellular protease of Penicillium roqueforti. II. Characterization of a purified enzyme preparation.


The effect of prymnesin on the electric conductivity of thin lipid membranes.


Kinetic studies of calcium movements in intestinal cells: effects of vitamin D deficiency and treatment.


Objective early identification of severe acute pancreatitis.


Endoscopic pancreatography in the evaluation of patients with suspected pancreatic pseudocysts.


Differential diagnosis of ulcerative and granulomatous colitis by sigmoidoscopy, rectal biopsy and cell counts of rectal mucosa.


Intermittent basal gastric hypersecretion following small bowel resection.


Galactose transport in rabbit ileum.

Galactose transport in rabbit ileum.


The Jarisch-Herxheimer reaction in syphilitic hepatitis.


Celiac disease: Endoscopic observations.


The radiology corner ischemic colitis.

The radiology corner ischemic colitis.


Iowa 500: the clinical and genetic distinction of hebephrenic and paranoid schizophrenia.


Iatrogenic dyskinesia. A unique reaction to parenteral methylphenidate.


Impairment and adaptation in chronic disabilities: spatial inattention.


The relationship between the changes in the interrenal, gonadal and thyroidal tissue of the air breathing fish, Heteropneustes fossilis (Bloch) at different periods of the breeding cycle.


A comparative study of progesterone- and cortisol-binding activity in the uterus and serum of pregnant and non-pregnant women.


Effect of relaxin on oestrogen-induced uterine luminal fluid accumulation in the ovariectomized rat.


Electrolyte and fluid appetite and balance in male guinea-pigs: effects of stilboestrol treatment and renal function tests.


An assessment of the possible role of 17alpha,20alpha-dihydroxy-4-pregnen-3-one in the regulation of testosterone synthesis by rat and rabbit testis.


Radioimmunoassay of oestrone, oestradiol-17alpha and -17beta in bovine plasma during the oestrous cycle and last stages of pregnancy.


The influence of maternal nutrition on plasma hormone and metabolite concentrations of foetal lambs.


Renal diuresis and antidiuresis after injections of arginine vasotocin in the freshwater eel (Anguilla anguilla L.).


Prolonged pseudopregnancy in mice bearing ectopic trophoblastic tissue.


Negative and positive effects of oestradiol upon luteinizing hormone secretion in the female rat.


Editorial: Drivers and deterrents.

Editorial: Drivers and deterrents.


Evidence that delta5-3beta-hydroxysteroid dehydrogenase activity in rat blastocysts is autonomous.


Editorial: Dissolving discs.

Editorial: Dissolving discs.


Editorial: Vitamin E and red cells.

Editorial: Vitamin E and red cells.


Testicular pain sensation in diabetic autonomic neuropathy. Testicular sensation was examined in 32 male diabetics with symptoms suggestive of autonomic neuropathy to evaluate its usefulness as a clinical sign in this condition. Vascular reflex responses to the Valsalva manoeuvre and sustained handgrip and blood pressure fall on standing were measured as objective tests of autonomic involvement. Absent or diminished testicular sensation correlated well both with the clinical features of autonomic neuropathy, except where impotence occurred alone, and with abnormal vascular reflexes. Most patients with impotence alone had normal testicular sensation and normal vascular reflexes. It is concluded that this sign is useful in diabetics with impotence, the presence of intact testicular sensation indicating that the impotence is unlikely to be due to autonomic neuropathy.


Diurnal variation in glucose tolerance and its reversal by lengthened fasting. In a group of healthy young male volunteers a worsened tolerance to oral glucose in the afternoon after a four-hour fast was reversed by a 12-hour fast. The latter also produced consistent mild hypoglycaemia from two and a half to four hours after the glucose loading irrespective of the time of day.


Aspects of plastic surgery. Scars.

Aspects of plastic surgery. Scars.


Conversations on the social services. City problems.


Controlled sedation with alphaxalone-alphadolone. Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit. This technique allowed rapid and accurate control of the level of sedation. It had three particularly useful applications: it provided "light sleep," allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system.Sedation was satisfactory for 86% of the total time, and no serious complications were attributed to the use of the drug. Furthermore, though alphaxalone-alphadolone was given for periods up to 20 days there was no evidence of tachyphylaxis or delay in recovery time.


Blood and neoplastic diseases. Pregnancy anaemia.


Letter: Antibacterial preparations in the B.N.F.


Letter: Isolation system for general hospitals.


Letter: Anticonvulsant osteomalacia and vitamin D.


Letter: Metastatic processes.

Letter: Metastatic processes.


Letter: Assessing the safety of comatose and postanaesthetic patients.


Letter: Studies of resistance to long-acting adrenergic beta-stimulators in asthmatic patients.


Letter: Renal disorders in hepatic failure.


Letter: Skull transillumination.

Letter: Skull transillumination.


Letter: Perinatal metabolism of diazepam.


Editorial: Antibiotics and respiratory illness.


Letter: Beclomethasone aerosol in treatment of non-specific pulmonary fibrosis.


Editorial: Tests of hearing in school.

Editorial: Tests of hearing in school.


Editorial: Diet and coronary heart disease.


Editorial: Liver tumours and the pill.

Editorial: Liver tumours and the pill.


Comparison of mobilization after two and nine days in uncomplicated myocardial infarction. A total of 189 patients with uncomplicated myocardial infarction were selected at random for early or late mobilization and discharge from hospital. Patients were admitted to the study after 48 hours in a coronary care unit if they were free of pain and showed no evidence of heart failure or significant dysrhythmia. Randomization was achieved by monthly cross-over of the three medical wards to which the patients were discharged. One group of patients was mobilized immediately and discharged home after a total of nine days in hospital, and the second group was mobilized on the ninth day and discharged on the 16th day. Out-patient assessment was carried out six weeks after admission. No significant differences were observed between the groups in terms of mortality or morbidity, as reflected by the incidence of recurrent chest pain or myocardial infarction, heart failure, dysrhythmia, or venous thromboembolism detected either clinically or by (125)I-labelled fibrinogen scanning.


Liver hamartomas in patients on oral contraceptives. Three cases are reported of tumour-like lesions of the liver in women who had been on oral contraceptives for long periods. These malformations have a prominent vascular component and may present with haemoperitoneum and shock. The possibility of an association between liver hamartomas and oral contraceptive therapy has to be considered.


Ward design in relation to postoperative wound infection: 3. The wound infection rates, nasal carriage rates, and nasal colonization rates were studied in a recently built surgical unit for two years when it was first opened. Five years later a further two-year period of study was undertaken.Judging by the incidence of postoperative wound infection, as far as both Staphylococcus pyogenes and Gram-negative organisms are concerned, there is no evidence that the environment has become less safe with use over the seven-year period since opening.


Linoleate and fatty-acid patterns of serum lipids in multiple sclerosis and other diseases. The linoleic acid content of serum lipids was measured in 47 patients with multiple sclerosis, 29 patients with other neurological diseases, 35 patients with acute non-neurological illnesses, and 49 healthy control subjects. Reduced linoleic acid content of serum lipids was not specific to multiple sclerosis and occurred in all ill patients with acute non-neurological illness. The fatty-acid pattern of serum lipids in illness resembles that of essential fatty-acid deficiency. It seems that this pattern of reduced linoleic acid content with increased oleic, palmitic, and palmitoleic acid content may be a general phenomenon in ill patients.


Talking with people about to die.

Talking with people about to die. Sixty patients receiving care for terminal cancer commented on their discussions with doctors and nurses. Of these, 40 had some awareness of dying and none disapproved of open discussion. Of the 21 reporting little or no truthful conversations with staff, nine were critical, but the other 12 were not dissatisfied, including some aware of the prognosis.


A social worker speaks.

A social worker speaks.


Post-traumatic progressive cortical thrombophlebitis.


Extension of family planning service in general practice. All general practitioners on the list of a single executive council were contacted and 91% were interviewed. They were asked about the type of family planning service currently provided and their willingness to extend the service. Only 3% said that they were not providing any service at the time of interview, but only 4% stated that they provided a complete range of techniques to all patients; almost two thirds of practitioners only provided advice and the "pill". Lack of training in family planning techniques emerged as the most important factor in determining the type of service provided. At the time of interview 64% of doctors stated that they would like further training, and 35% of all doctors asked for a full course of clinical training. Many general practitioners (81%) were willing to extend their family planning services but 65% wanted financial reimbursement and 50% needed additional administrative support as prerequisites.


Referees and rejects.

Referees and rejects.


Serum hepatitis associated with repeated acupunctures.


Complication of proximal gastric vagotomy.


Hyperthyroidism and giant-cell arteritis.


Conversations on the social services.

Conversations on the social services.


Ischaemic colitis due to myxoedema.

Ischaemic colitis due to myxoedema.


Jaundice in acute pustular psoriasis.

Jaundice in acute pustular psoriasis.


Fibre and irritable bowels.

Fibre and irritable bowels.


Withdrawal of rifamide.

Withdrawal of rifamide.


Rapid weight loss in children.

Rapid weight loss in children.


Death after E.C.T.

Death after E.C.T.


Teaching model for tracheal suction.

Teaching model for tracheal suction.


General-practitioner deputizing services.


Prolonged effect of antihypertensive agents.


Minors and contraception.

Minors and contraception.


Tests for immigrant doctors.

Tests for immigrant doctors.


Bladder muscle regeneration.

Bladder muscle regeneration.


A contribution to biology of Grawitz's kidney tumor: heterotransplanatation.


Adrenergic control of ureteral tonus.

Adrenergic control of ureteral tonus.


Improved plasma testosterone assay by competitive protein binding and clinical availability.


The effects of unilateral vesical denervation and partial cystectomy on canine bladder function.


Prevention of oxalate and phosphate lithiasis by alanine.


Effects of inhibition of steroid biosynthesis on the lymphoid system.


Simple synthetic and natural urines have equivalent anticalcifying properties.


Pharmacoclinical study of oral estramustine phosphate (Estracyt) in advanced carcinoma of the prostate.


Making the annual pediatric evaluation more relevant to the needs of the child.


Recreation and hobbies as developmental supports for a child with sickle cell anemia.


Letter: The crying infant.

Letter: The crying infant.


Letter: Acellular CSF in early meningitis.


Serum alkaline phosphatase in cystic fibrosis. Interpretation of elevated values based on electrophoretic isoenzyme analyses.


The practical management of urinary tract infections in children. Description of an approach to differentiate surgical from nonsurgical cases.


Axillary-contralateral brachial artery bypass for arm ischemia. A right axillary to left brachial arterial bypass (saphenous vein) was used in the treatment of a left subclavian artery obstruction secondary to radical mastectomy and irradiation 28 years previously. The axillary bypass was chosen over other surgical approaches because of its simplicity and efficacy.


Comparative effects of left atrial or left ventricular bypass on coronary sinus flow and oxygen usage in dogs. Comparative coronary sinus flow rates and oxygen AV difference were studied in dogs undergoing left heart bypass with left atrial or left ventricular drainage at similar maximum obtainable flow rates. Left atrial bypass decreased the coronary sinus flow rates and oxygen consumption when compared with control values. These values were further decreased when left ventricular bypass was used. The oxygen consumption data were highly significant and give further evidence of increased effectiveness of complete bypass of the left ventricle in myocardial support systems.


Abdominoperineal resection for carcinoma in the community hospital. All abdominoperineal resections for carcinoma of the rectum carried out 1963-1972 in two small community hospitals are reviewed. Seventy-six patients were found: males slightly outnumbered females; the average age was 61. There were 67 adenocarcinomas, 7 squamous cell carcinomas and one each of villous adenoma and carcinoid. Distribution of Dukes' classification was: A-20, B-26, C-21, D-9. In an average case the operative time was 3 hours, 25 minutes, 4 units of blood were used, and postoperative hospital stay was 30 days. Postoperative complications were recorded in over 50% of the patients with reoperation needed in 26% of all patients and delayed complications occurred in 41%. The operative mortality was 1.3%. Five year followup was possible in 40 of 43 patients; survival according to Dukes' classification was A-80%, B-53%, C-9% and D-25% with overall survival 45%.


Comparison of surgical managements for pulmonary emboli. The high incidence of pulmonary embolism is well documented. At first suspicion of an embolism attack, adequate anticoagulant therapy was administered to 86% of the patients in this study. With failure of anticoagulants preoperatively, 30 patients received partial interruption of the IVC, 26 patients had their IVC ligated. Postoperatively, anticoagulants were administered to 64% of the patients who subsequently suffered recurrent attacks of embolism or new episodes of acute thrombophlebitis. These patients also had a substantial hazard of hemorrhage since 48% of the patients on heparin required transfusion. Postoperative mortality for the ligation group was associated with underlying conditions of the patients. These patients subjected to IVC plication had more deaths due to recurrence of pulmonary emboli and were demonstrated to have a substantially higher recurrence rate of pulmonary embolus. Reasons for this recurrence in both groups are discussed. Severe leg sequlae problems often associated with ligation were not encountered but were present in several patients subjected to plication.


The effect of parietal cell and truncal vagotomy on gastric and duodenal contractile activity of the unanesthetized dog. The antral-duodenal contractile relationship was studied in control, after parietal cell vagotomy and truncal vagotomy conditions using extraluminal strain gage transducers. All conditions were investigated under interdigestive and digestive states and after insulin, bethanechol and histamine. After parietal cell vagotomy, there was minimal alteration of the antral-duodenal relationship in both the interdigestive and digestive states. The number and amplitude of contractions on both the antrum and duodenum (as reflected by a motility index) were not changed from control by the various stimulants. The one exception was that histamine markedly stimulated the duodenal contractile activity. In the truncal vagotomy condition, there was a total disruption of the antral-duodenal relationship in the interdigestive and digestive states. There was a significant decrease in the number and amplitude of contractions occurring on the antrum during the interdigestive and after insulin stimulation. Food was ineffective in stimulating the antrum in 2 of 3 dogs. In contrast, motor activity of the duodenum was minimally influenced by truncal vagotomy. In conclusion, parietal cell vagotomy has minimal disruptive effects on the antralduodenal relationship while truncal vagotomy reduces antral contractile activity.


Pancreatic hypoperfusion and the production of a myocardial depressant factor in hemorrhagic shock. Hemorrhagic shock was produced in dogs by bleeding to a systemic blood pressure of 45 mm Hg for 3 hours, followed by reinfusion of the shed blood. A rapid decrease in pancreatic blood flow occurred and pancreatic perfusion remained at 15-25% of control over the entire 3-hour oligemic period. As a consequence of this marked degree of pancreatic hypoperfusion, autolytic changes occurred in pancreatic acinar cell ultrastructure, particularly in the enlarging of lysosomes which developed many vacuoles. Plasma proteolytic indices (e.g., cathepsin D activity and amino nitrogen concentration) markedly increased during shock as well as the activity of a myocardial depressant factor (MDF). MDF was also produced in incubated pancreatic homogenates obtained from nonshocked dogs and in non-incubated homogenates from shocked dogs. MDF activity in the homogenates was closely correlated with amino nitrogen concentration. These data suggest that pancreatic hypoperfusion plays a key role in MDF formation and ultimately in the pathogenesis of circulatory shock. Moreover, MDF activity was found not to be associated either with pentobarbital concentration or the salt content of active fractions of plasma and pancreatic tissue. Ashing of active fractions was very effective in destroying MDF activity. These data are consistent with the earlier findings that indicate MDF to be a peptide having a molecular weight of 500-1,000.


The roles of intraluminal chyme and vasomotor response in the pathogenesis of non-occlusive intestinal infarcts. The purpose of this study is to clarify the role of intraluminal chyme and the splanchnic vasomotor reaction on the pathogenesis of non-occlusive intestinal infarcts. In 5 mongrel dogs, 3 types of intestinal loops were created. A cervical loop, which is a heterotopic autotransplant of a segment of intestine, contains no chyme and is disconnected from the splanchnic innervation. A Thiry-Vella loop simultaneously constructed in the abdomen is also devoid of intraluminal chyme, but is still innervated. The intestine-in-continuity possesses both splanchnic innervation and intraluminal chyme. Hemorrhagic shock was then induced and the morphological response of the three types of intestine examined. The results indicate that the cervical loop is least damaged, whereas both the Thiry-Vella loop and the intestine-incontinuity are both severely damaged. It is concluded that in the non-occlusive hemorrhagic infarction of the intestinal mucosa, the peculiar splanchnic vasomotor response plays the dominant role. The pathogenesis of non-occlusive intestinal infarcts and its clinical implications are discussed.


Prevention of bile reflux-induced acute gastric ulceration in the rat by cholestyramine. The role of bile salts and refluxed duodenal content in the pathogenesis of acute gastric ulcers in the shocked rat were examined. The addition of cholestyramine to duodenal contents inhibits their ulcerogenic action in the stomach of rats challenged by an acid load, (100 mEq/l Hcl) and subsequently bled to a mean blood pressure of 20 mm Hg. Also, bile duct ligation 2 days before the reflux procedure and subsequent shock also inhibited ulcer formation. An ex vivo rat gastric chamber was used to further demonstrate that the "barrier" breaking action of bovine sodium taurocholate and sodium lauryl sulphate could be prevented by cholestyramine. Cholestyramine also inhibited the usual rapid depression of the transmucosal potential difference (PD) produced by both of these agents. It is concluded that cholestyramine protects the gastric mucosa from ulceration by blocking the barrier breaking action of bile salts in duodenal chyme.


Effect of changes in inspired oxygen tension on wound metabolism. This work was prompted by earlier findings of the beneficial effect of increased oxygen supply on wound healing. Enzyme activities in the limiting step of glycolysis, citric acid cycle and pentose phosphate cycle were determined in cellulose sponge implants of rats chronically, breathing 12% O(2), air or 55% O(2.) Respiratory gas tensions and concentrations of pyruvate and lactate were measured in wound fluid aspirated from the implants. Significant portions of repair tissue exist in conditions of extremely low oxygen tension. Probably because all added oxygen is readily consumed, the wound fluid PO(2) increased only slightly in hyperoxic environment. The wound PCO(2) increased in parallel with the inspired PO(2), probably due to enhanced production of carbon dioxide. Hyperoxia shifted the wound metabolism from anaerobic towards aerobic glycolysis. This occurred concurrently with activation of citric acid cycle. Succinic dehydrogenase, a linking enzyme between citric acid cycle and electron transfer chain, also increased with increasing oxygen tension. This oxygen-induced metabolical change has been previously observed in many other tissues.


Gastrin release by ethanol in man and in dogs. In man, oral or intravenous administration of ethanol caused a small but definite increase in peripheral serum gastrin concentration (measured by radioimmunoassay). In dogs, perfusion of the antrum with 10% ethanol caused an immediate increase in gastrin levels in the antral venous outflow. Acidification of the perfusate did not totally block the gastrin release from the antrum. Intravenous infusion of ethanol in dogs caused release of gastrin from the antrum.


Long term results of gastrectomy with respect to blood lipids, blood pressure, weight and living habits. A sample of ambulant Japanese-American men (ages 45-69 years), was divided into those having a previous partial gastrectomy and a control non-gastrectomy population. Three-hundred-and-forty-seven men with a history of partial gastrectomy weighed less and had lower values for serum cholesterol, triglyceride, and blood pressure than did the control population of 7,598 men. The depressed lipid and blood pressure values could not be entirely explained by the reduced weight. Likewise, none of these differences appeared related to diet or living habits. Those operated on for gastric ulcer had, on the average, lower systolic pressures than duodenal ulcer patients and those with gastrojejunal anastamoses had lower cholesterol levels than patients with a gastroduodenostomy.


The relationship of circulating endogenous endotoxin to hemorrhagic shock in the baboon. Experiments were carried out to test the hypothesis that during hemorrhagic shock endotoxin enters the circulation from ischemic bowel by way of the portal venous system and is then associated with irreversibility of the hemorrhagic shock state. After placement of sampling catheters in the portal vein, right atrium, and aorta, 14 awake, restrained baboons were subjected to 1 hour of hemorrhagic shock at a mean arterial pressure (MAP) of 60 torr followed by a second hour at 40 torr MAP. Six animals were resuscitated with Ringers lactate and their shed blood; 8 were maintained hypotensive until death. Serial blood samples were analyzed for the presence of endotoxin. Endotoxemia was found infrequently, with no greater incidence (p > 0.6) in portal venous samples than in systemic blood, so these data were pooled for further analysis. Furthermore, endotoxemia was no more frequent (p > 0.6) late in shock than it was in early shock or during the baseline period. Autopsy showed no evidence of ischemic damage to the splanchnic viscera. It was concluded that spontaneous endogenous entotoxemia is not a common feature of hemorrhagic shock in baboons and is not related to the duration or degree of severity of hemorrhagic shock in this subhuman primate species.


Cystic disease of the liver.

Cystic disease of the liver. The clinical presentation, pathology, and appropriate surgical management of cysts of the liver were analyzed in a review of 150 cases of hepatic cystic disease encountered surgically at the Mayo Clinic from Jan. 1, 1954, through Dec. 31, 1971. The incidence of this disease was 17 per 10,000 abdominal explorations. The series included 82 solitary cysts, of which 15 produced symptoms; 49 multiple cysts, of which 7 were symptomatic; 13 hydatid cysts, of which 12 were symptomatic; 3 traumatic cysts, of which 2 were symptomatic; and 3 inflammatory cysts, of which 1 was symptomatic. Symptoms, when present, comprised (in order of frequency) the presence of an abdominal mass, abdominal pain, and hepatomegaly. Congenital and hydatid cysts were located most often in the right lobe of the liver. The smallest cysts were the multiple cysts (average diameter, 4.3 cm) and the largest were the hydatid cysts (average diameter, 10.5 cm). Histologically, the lining of the congenital cysts most often was of cuboidal epithelium. The treatment of congenital cysts included simple biopsy, aspiration, and excision. In cases of hydatid cysts, preliminary sterilization was found to be essential prior to aspiration. Hydatid cysts may be excised or opened, evacuated, and the cavity obliterated. In certain cases hepatic resection may be warranted in order to remove all of the hydatid disease.


Steroid effect on the release of the lysosomal enzyme acid phosphatase in shock. The effect of corticosteroids on cellular resistance in shock was studied by serial measurement of the serum concentration of the lysosomal enzyme acid phosphatase in untreated and steroid dogs subjected to hemorrhagic, endotoxin and cardiogenic shock. In each shock category, elevation in serum acid phosphatase was significantly less in steroid treated dogs as compared to untreated animals at corresponding time intervals. This difference was most apparent in endotoxin shock, next in hemorrhagic shock and least in cardiogenic shock. Steroid treatment also reduced the serum lactate increment in hemorrhagic and cardiogenic shock and delayed or reduced the onset and severity of the occurring acidosis, an apparent reflection of the ability of steroids to promote increased tissue perfusion. In addition, steroid treatment increased or prolonged survival in all three shock groups. By showing that glucocorticoids affect a reduction in the release of the lysosomal enzyme acid phosphatase during shock, the study offers direct evidence that steroids enhance cellular resistance to shock stress in the dog. Whether this salutary effect is due solely to the ability of steroids to stabilize cellular membranes or is in part secondary to promoting improved tissue hemodynamics could not be established. The interpretation and clinical application of these results must take into account the possibility of a species specific response.


Glucose tolerance and insulin response during and after elective skeletal surgery. Six patients undergoing elective femoral osteotomy were subjected to a series of intravenous glucose tolerance tests and plasma insulin determinations in a study of the way in which a standard operation affects carbohydrate metabolism. The glucose tolerance of all patients assumed a diabetic pattern; this was already observable in the test made on admission to the operating theater and was still evident during the last test on the second postoperative day. The changes were most profound during and four hours after the operation. Insulin secretion was suppressed on the day of operation, but exceeded preoperative values in the postoperative period. Urinary excretion of catecholamines was determined in 4 patients; there was no correlation between the degree of insulin suppression and the catecholamine output. The assumption that the hyperglycemic response and insulin suppression are mediated along splanchnic neural pathways was not confirmed in a quadriplegic patient, who responded to an intravenous glucose tolerance test soon after the injury with hyperglycemia, insulin suppression and a low catecholamine output. It is concluded that the hyperglycemia and insulin suppression observed after trauma represent a complex and purposeful metabolic response, in which several causative factors are involved.


Premature ageing and occurance of altered enzyme in Werner's syndrome fibroblasts.


Life span of erythrocyte membrane protein.


New directions in molecular biology.

New directions in molecular biology.


Molecular biologists come of age in Aries.


Actin in the alga, Chara corallina.

Actin in the alga, Chara corallina.


Photoeffects in a flavin-containing lipid bilayer membrane and implications for algal phototaxis.


Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid.


Atmospheric pressure during incubation and post-hatch behaviour in chicks.


Nickel accumulation by Hybanthus floribundus.


Letter: Macromolecular structures for undergraduates.


Size-distribution pattern of polycyclic aromatic hydrocarbons in airborne particulates.


The reaction of ozone with perfluorinated polyolefins.


Multielement analysis of sludge samples by instrumental neutron activation analysis.


The solubility product of ferrous phosphate.


Studies of air-borne pollutant levels.

Studies of air-borne pollutant levels.


Attraction of the male pink bollworm moth under laboratory and field conditions.


Occupational role innovators and sex role attitudes.


Patterns of change in medical student career choices.


Attending-physician--house-staff interactions on a private medical service.


Development of primary care physician manpower in England and Israel.


Scholastic ability versus attitude, time, and performance on programmed instruction.


Evaluation of a systematic approach to teaching interviewing.


Measuring performance in the surgical clerkship.


The use of behavioral objectives in the development and evaluation of a third-year surgical clerkship.


Innovations in ambulatory care and teaching: a house staff group practice.


An evaluation for teaching interviewing in multiple settings.


Continuing education: what do we mean by it, and why is it important?


State funding for targeted programs in graduate medical education.


Model for postgraduate medical education: study of Crohn's disease in New Mxico.


Letter: Course in human sexuality.

Letter: Course in human sexuality.


Editorial: The right to health care.

Editorial: The right to health care.


A comparison of trephine and Franklin-Silverman needles for percutaneous lung biopsy.


Disseminated coccidioidomycosis among southwestern American Indians.


Pneumonitis with pleural effusion in children due to Mycoplasma pneumoniae.


Use of the RC time constant for CO in the measurement of diffusing capacity.


Thoracic kidney.

Thoracic kidney.


Letter: Predicted values for closing volumes using a modified single breath nitrogen test.


Interstitial pneumonia after prolonged treatment with cyclophosphamide.


Letter: Broncholithiasis in silicosis.

Letter: Broncholithiasis in silicosis.


Acute cadmium intoxication. Early selective lesions of endothelial clefts.


A preliminary report of nephropathy in hyperuricemic rats.


The juxtaglomerular apparatus in mercury intoxication in rats. Light and electron microscopic studies.


Effect of reserpine on the juxtaglomerular granular cells and renal nerves.


A method for automatic storage and retrieval of alphabetic autopsy diagnoses coded by computer.


Production and prevention of fatty liver in rats fed clofibrate and orotic acid diets containing sucrose.


The inhibition of rat liver nuclear ribonucleic acid synthesis by galactosamine and its reversal by uridine.


Relationship of amyloid deposits in the human aorta to aortic atherosclerosis. A postmortem study of 100 individuals over 60 years of age.


Effect of monosodium glutamate on the endocrine glands and on the reproductive function of the rat.


Semen analysis: evidence for changing parameters of male fertility potential.


Editorial.

Editorial.


Immunologic implications of vasectomy. II. Serum-mediated immunity. 30 male rats in groups of 10 underwent standard vasectomy with ligation of the vas deferens; vasectomy without ligation of the vas deferens (permitting intraperitoneal drainage of the open vas deferens); or sham vasectomy.  Assays (in vivo and in vitro) for serum-mediated immunity to syngeneic spermatozoa were performed with each experimental group 90 days postvasectomy.  The tests were the Arthus reaction by footpad swelling response 3 hours following footpad injection of syngeneic spermatozoa, and the release of radioactivity from chromium labeled spermatozoa following incubation with experimental sera,  indicating cytotoxic antibodies to spermatozoa.  The presence of serum-mediated immunity specific to spermatozoa could be demonstrated only in the group of rats which underwent conventional abdominal vasectomy with ligation of the vas deferens.  This group's footpad swelling response (p.01) and the chromium labeled results (p.001) were statistically significant.


Immunologic implications of vasectomy. I. Cell-mediated immunity. The development of sperm-specific, cell-mediated immunity in postvasectomized rats was determined using 3 different types of assays: footpad swelling response to injected syngeneic spermatozoa; radioactive release from chromium labeled  spermatozoa; and release of macrophage migration inhibition factor from lymphocytes responding to spermatozoa.  30 male rats underwent vasectomy with 1 of the following in groups of 10: 1) ligation of the vas deferens; 2) vasectomy without ligation of the vas deferens; or 3) sham vasectomy.  Assays for cell-mediated immunity were performed 90 days postvasectomy.  Cell-mediated immunity was present only in rats without ligation of the vas deferens.  The swelling response to spermatozoa in Group 2 rats was statistically significant (p less than .01).  A lymphocyte cell-mediated release of chromium from labeled spermatozoa was highly significant when Group 2 animals were the source of spleen cells (p less than .0005).  Macrophage migration inhibition was significant (p less than .01) in supernatants taken from cultures of syngeneic spermatozoa with spleen cells of Group 2 rats, vasectomized without vas ligation.  Possible reasons for these results were presented.


Insulin, glucagon and growth hormone in primary adult myxoedema.


In vivo studies on 5-hydroxytryptamine and insulin secretion in dogs and in man.


Pharmacological fibrinolysis in diabetes mellitus.


Approximate confidence limits for the concentration of insulin in radioimmunoassay.


Dynamics of insulin release and microtubular-microfilamentous system. II. Effect of vincristine.


Interrelationship between glucose and acetoacetate metabolism in human adipose tissue.


The amnesic syndrome of posterior cerebral artery occlusion.


Effect of small doses of insulin in vivo on the proliferation and cellularity of adipose tissue.


Acid monoamine metabolites of cerebrospinal fluid in meningitis and encephalitis.


Use of serial cisternograms to document dynamic changes in the development of communicating hydrocephalus: a clinical and experimental study.


Cerebrospinal fluid cholesterols and phospholipids in multiple sclerosis.


A re-evaluation of the decamethonium test for myasthenia gravis.


Intravenous glucose tolerance during treatment with phenytoin.


Leprosy in Ethiopia.

Leprosy in Ethiopia.


High pressure injection injuries of the hand treatment by early mobilization.


Spondylolisthesis of the fifth lumbar vertebra (4th degree)--autogenous fusion.


Double screw osteosynthesis in the treatment of fractures of the femoral neck.


Adamantinoma. A case report.

Adamantinoma. A case report.


Studies with a new type of upper-extremity cast.


Sale of goodwill-some legal-economic aspects.


An electron-microscopical analysis of the square areas and diameters of the cochlear nerve fibres in cats.


Behavioral auditory function after transection of crossed olivo-cochlear bundle in the cat. II. Conditioned visual performance with intense white noise.


The release of acetylcholine (ACH) by the crossed olivo-cochlear bundle (COCB).


Genetic progressive hearing loss in the C57-b16 mouse. Relation of behavioral responses to chochlear anatomy.


The effect of preservation on the behaviour of homologous ossicular grafts.


Inter-saccadic interval analysis of vestibular nystagmus.


Otitis externa and allergic contact dermatitis.


Sensitivity of the nasal vessels of the cat to chemical agents after sympathetic and parasympathetic denervation.


The effectiveness of a sternomastoid muscle flap in preventing post-parotidectomy occurrence of the Frey syndrome.


Giant cell tumors of bone in the E.N.T. organs. Report of two cases in the frontal sinus.


In-vitro inhibition by unsaturated fatty acids of the PPD- and PHA-induced lymphocyte response.


Histochemical demonstration of sympathetic adrenergic denervation in human skin.


Effect of diphenylhydantoin on connective tissue.


Progressive myoclonus epilepsy. A clinical and histopathological study.


A quantitative electromyographic study of the effects of dantrolene sodium on skeletal muscle in normal subjects.


Progressive myoclonus epilepsy. Electroencephalographical findings.


Studies on genomic interactions in hybrids between enzymic variants of a human cell line.


Architectural and engineering aspects of the operating room environment.


Compatibility and flexibility in surgical suites.


Is airborne infection in operating-theatres an important cause of wound infection in general surgery?


Comparison of ventilation systems in operating rooms.


Electrical environment in the operating room.


The bacteriology of surgical theatres with and without unidirectional airflow.


Operating room apparel and drapes.

Operating room apparel and drapes.


The evolution of a synorgan. Nineteen stages concerning teeth and dentition from the pelycosaur to the mammalian condition.


Identification of 2-O (indole-3-acetyl)-D-glucopyranose, 4-O-(indole-3-acetyl)-D-glucopyranose and 6-O-(indole-3-acetyl)-D-glucopyranose from kernels of Zea mays by gas-liquid chromatography-mass spectrometry.


Requirement of an activator for the hydrolysis of sphingoglycolipids by glycosidases of human liver.


D-Psicose metabolism in the rat.

D-Psicose metabolism in the rat.


Synthesis of 8-(hydroxyalkyl)adenines.

Synthesis of 8-(hydroxyalkyl)adenines.


Competition and the structure of bird communities.


Local anesthetics: effects on permeability properties of nodal membrane in myelinated nerve fibres from xenopus. Potential clamp experiments.


Regional cerebral blood flow in the rat measured by the tissue sampling technique; a critical evaluation using four indicators C14-antipyrine, C14-ethanol H3-water and xenon.


Microbial films in nature.

Microbial films in nature.


Further observations on an algicide produced by Pandorina morum, a colonial green flagellate.


Distribution of renal cortical blood flow during hemorrhagic hypotension in conscious dogs.


Autoregulation of capillary hydrostatic pressure in skeletal muscle during regional arterial hypo- and hypertension.


The effect of glucagon on hepatosplanchnic hemodynamics, functional capacity, and metabolism of the liver in cats.


The effect of barbiturate on retinal functions. I. Effects on the conventional electroretinogram of the sheep eye.


Effect of lowered CSF sodium concentration on the central control of fluid balance.


Utilization of energy reserves by cells isolated from newborn rat brain.


The effect of glycerol on the postexercise lactate clearance.


Effects of ethanol, tert. butanol, and clomethiazole on net movements of sodium and potassium in electrically stimulated cerebral tissue.


Plasma hyperosmolarity and pulmonary capacitance vessels.


Effect of changes in plasma Na+ and Ca++ ion concentration on body temperature during exercise.


Hypoxia causes prostaglandin release from perfused rabbit hearts.


Blood flow and oxygen consumption in the rat brain in dilutional anemia.


Measurement of colloid osmotic pressure of interstitial fluid.


Failure of adrenalectomy to influence the acute effect of FSH on ovarian metabolism.


The structure of ribonuclease at 2-5 Angström resolution.


Deoxyadenylate-rich and deoxyguanylate-rich regions in mammalian DNA.


Polynucleotide sequences in eukaryotic DNA and RNA that form ribonuclease-resistant complexes with polyuridylic acid.


Polyadenylic acid-containing RNA in Xenopus laevis oocytes.


Repetitive and non-repetitive sequence in sea urchin heterogeneous nuclear RNA.


Evidence for post-transcriptional control of the morphogenetic genes of bacteriophage lambda.


Letter: A saccharide ligand on the outer surface of retinal rod disc membranes.


Aspirin intolerance. II. A prospective study in an atopic and normal population.


Cell-mediated immunity in leprosy and transfer of delayed hypersensitivity reactions.


Triad of legislative programs aims at health care reforms.


A case of episodic urticaria due to saccharin ingestion.


Pulmonary embolism: silent killer of the elderly.


HMO legislation directed toward more benefits for more people.


Selecting appropriate therapy for bronchial carcinoma.


Hypersensitivity pneumonitis.

Hypersensitivity pneumonitis.


Pulmonary problems in general surgery.

Pulmonary problems in general surgery.


Diagnosing and treating acute respiratory failure.


The solitary pulmonary nodule: benign or malignant?


Modern concepts in treating tuberculosis.


Diagnostic evaluation of pleural effusion.


Geriatric sexuality: normal, needed, and neglected.


Long-term prognosis of patients with incomplete bilateral bundle branch block complicating acute myocardial infarction. Role of cardiac pacing.


Phenylephrine-induced atypical chest pain in patients with prolapsing mitral valve leaflets.


Spontaneous changes in left ventricular function between sequential studies.


Role of diabetes in congestive heart failure: the Framingham study.


Antiarrhythmic and circulatory effects of Astra W36095, a new lidocaine-like agent.


Distinctive time course of ventricular vulnerability to fibrillation during and after release of coronary ligation.


Effects of coronary stenoses on coronary flow reserve and resistance.


Changes in left ventricular wall dimensions during regional myocardial ischemia.


Simulated left atrial tumor. A hemodynamic, echocardiographic and cineangiographic study.


Long-term canine model for echocardiography.


Pulmonary vascular disease in complete transposition of the great arteries: a study of 200 patients.


Cardiac involvement in Sandhoff's disease. Inborn error of glycosphingolipid metabolism.


Risk factors of brain abscess in patients with congenital heart disease.


Left ventricular function in chronic constrictive pericarditis.


Noninvasive methods for assessing left ventricular performance in man.


Editorial: Blind defibrillation.

Editorial: Blind defibrillation.


Letter: Guidelines for use of balloon-tipped catheter.


Letter: Impulse formation in the left atrium.


Letter: Transvalvular gradient in aortic stenosis.


President's page: life expectancy.

President's page: life expectancy.


Letter: Oral lorazepam.

Letter: Oral lorazepam.


Letter: Placement of mental retardates.

Letter: Placement of mental retardates.


Letter: Plastic banding system.

Letter: Plastic banding system.


A comparative study of pycnodysostosis, cleidocranial dysostosis, osteopetrosis and acro-osteolysis.


Effects of propanidid and thiopentone on the acid-base status of babies delivered by elective caesarean section.


Posterior dislocation of the hip. Clinical observations and review of literature.


Bio-engineering--a perspective.

Bio-engineering--a perspective.


Multiple myeloma. II. The value of melphalan.


Social-psychiatric aspects of epilepsy. Special reference to the South African National Epilepsy League (SANEL).


The effect of repeated plucking on mouse skin cell kinetics.


Cell layers and density of Negro and Caucasian stratum corneum.


In vitro neoplastic transformation of mouse skin cells: morphology and ultrastructure of cells and tumors.


Skin procollagen peptidase in normal and pathologic conditions.


Enzymatic formation of L-pyrrolidone carboxylic acid in mammalian epidermis and other tissues.


In vitro lymphocyte responses in contact hypersensitivity IV.


A study of the effect of exposure in the reticulo-rumen of the cow on the strength of cotton, grass, hay and straw.


Effects of methotrexate on the liver in psoriasis.


The rejection of a diet which has been associated with a single administration of an histidine-free amino acid mixture.


The utilization of protein and excretion of uric acid in germ-free and conventional chicks.


Thermic effect of glucose and amino acids in man studied by direct and indirect calorimetry.


The adaptation in muscle oxidation of leucine to dietary protein and energy intake.


The effect of molybdenum levels in sorghum (Sorghum vulgare Pers.) on uric acid and copper excretion in man.


Iron absorption from rice meals cooked with fortified salt containing ferrous sulphate and ascorbic acid.


Ruminal biosynthesis of aromatic amino acids from arylacetic acids, glucose, shikimic acid and phenol.


Heat loss and energy retention during growth in congenitally obese and lean rats.


The determination of tryptophan in purified proteins and in feeding-stuffs.


The effect of Lampren on human cells in culture.


Measurement of rate of extravasation of plasma protein in inflammatory responses in guinea-pig skin using a continuous recording method.


Effect of pregnancy serum on experimental inflammation.


Pathophysiological changes resulting from intravenous injection of ovine hydatid cyst fluid to sheep.


An electron microscope study of the response of mesothelial cells to the intrapleural injection of asbestos dust.


Increased phagocytic cell activity and anaemia in Corynebacterium parvum treated mice.


Studies on the effects of paraquat and diquat on cells in culture. Viability of macrophages and fibroblasts incubated with paraquat and diquat.


Fine structural aspects of lymphoedema in various tissues and the effects of treatment with coumarin and troxerutin.


Arterial changes in Crotalaria spectabilis-induced pulmonary hypertension in rats.


Histology and ultrastructure of metaplasia of alveolar epithelium following infection of mice and hamsters with influenza virus.


The ultrastructure of the lysis of fibrin by endothelium in vitro.


Radiological diagnosis of crocidolite induced pleural mesotheliomata in the rat.


Similarity of chronic copper toxicity in rats to copper deposition of Wilson's disease.


Protection by a small dose of carbon tetrachloride against the toxic effects of dimethylnitrosamine in rats.


Mechanisms of delayed red cell destruction after thermal injury. An experimental in vitro sem study.


Copper in supernatant fractions of various rat tissues. Studies with 67Cu.


Long-term body retention of radiocopper (67Cu) and the diagnosis of Wilson's disease.


Wilson's disease. Electroencephalographic and evoked potential studies.


Bicarbonate excretion in Wilson's disease (hepatolenticular degeneration).


Effects of penicillamine therapy and low-copper diet on dysarthria in Wilson's disease (hepatolenticular degeneration).


Psychologic investigation of Wilson's disease.


The structural components of the intervertebral disc. A study of their contributions to the ability of the disc to withstand compressive forces.


The prime static stabilizer of the medical side of the knee.


Epiphyseal-plate cartilage. A biomechanical and histological analysis of failure modes.


Elevation of intramedullary pressure when methylmethacrylate is inserted in total hip arthroplasty.


Stress-induced potentials in moist bone in vitro.


Scheuermann's kyphosis and roundback deformity. Results of Milwaukee brace treatment.


Acceleration of fracture healing distal to a venous tourniquet.


The clinical significance of osteomedullography in fractures of the tibial shaft.


Osteogenesis imperfecta: clinical evaluation and management.


Fracture of the capitulum humeri. Treatment by excision.


Chronic pubic symphysiolysis. A case report.


Congenital bowing and intraosseous neurofibroma of the ulna. A case report.


Benign osteoblastoma of the atlas. A case report.


Synovial chondrosarcoma. Report of a case.


Contracture of the deltoid muscle in the adult after intramuscular injections.


Bilateral, sequential rupture of the patellar tendon in systemic lupus erythematosus. A case report.


Simultaneous bilateral rupture of the patellar tendon and quadriceps expansions in systemic lupus erythematosus. A case report.


Double acromion and coracoid processes.

Double acromion and coracoid processes.


Metastatic hemangiopericytoma cured by radiotherapy. A case report.


Giant-cell tumor of the scapula treated by total scapulectomy. A case report.


Monteggia fracture. Presentation of an unusual case.


Tomography for evaluation of congenital dislocation of the hip while in a spica cast.


Editorial: Food revisionists.

Editorial: Food revisionists.


Editorial: Fatal insect stings.

Editorial: Fatal insect stings.


Editorial: Giardiasis.

Editorial: Giardiasis.


Editorial: Clinical public health doctors.


Long-term follow-up of therapeutic starvation. A total of 75 grossly obese patients were admitted to hospital for 80 episodes of prolonged starvation. Five took their own discharge within two weeks of admission and 12 defaulted from follow-up within 12 months of discharge. The others were all followed up for periods of 12 to 64 months. Altogether 39 episodes in 34 patients were classified as failures, eight as modified successes, and 16 as successes, though five of the latter patients subsequently defaulted. Success was associated with regular follow-up attendance but could not be otherwise predicted. A number of patients obtained tangible benefit from starvation despite a subsequent gain in weight.


Development of heart valve lesions during methysergide therapy.


Energy provision, tissue utilization, and weight loss in prolonged starvation. Daily weight loss measurements in 76 fasting, obese patients (58 females, 18 males) have shown a characteristic pattern of rapid loss initially (up to day 14) followed by a slower but uniform reduction in weight. There were significant sex differences. Measurements of tissue breakdown showed that the initial rapid weight loss was due to the continuing utilization by the nervous system of glucose derived from lean tissue. This requirement fell noticeably from the second week of starvation. Irreversible fluid elimination also contributed to the initial phase of rapid weight loss. Fat remained the primary source of energy throughout starvation and in established fasting (more than 14 days) contributed 96% of that requirement.


Radioisotopic bone scintigraphy with the gamma camera in the investigation of prostatic cancer. Experience with x-rays, strontium-87m scintigraphy, and technetium-99m polyphosphate scintigraphy in the identification of bone metastases in 201 patients with prostatic cancer is reviewed. About 40% of the patients had demonstrable metastases in bone at the time of first presentation.Comparative studies of 247 x-ray and (87m)Sr surveys indicated that x-rays failed to detect metastases in 10% of cases where they were identified by (87m)Sr but that the isotopic survey similarly failed to detect radiologically evident deposits in 7% of cases.Similar studies comparing (99m)Tc polyphosphate surveys with x-ray scans showed that x-rays missed isotopically detected metastases in 12% of cases, but in only one survey out of 67 did the isotope miss radiologically evident deposits. In a series of 32 patients investigated by both isotopic techniques (99m)Tc polyphosphate did not fail to detect any metastases and identified deposits in one patient in whom they were missed by (87m)Sr scintigraphy. About 15% of both x-ray and (87m)Sr surveys gave equivocal results, but only 3% (2 out of 67) of (99m)Tc polyphosphate surveys were equivocal.We concluded that (99m)Tc polyphosphate bone scintigraphy with the gamma camera was the most reliable of the techniques used for the identification of bone metastases in patients with carcinoma of the prostate. The results of scintigraphy with (87m)Sr suggested that serial surveys may provide early evidence of hormone resistance in prostatic cancer.


Medicine in China: best of the old and the new.


Letter: Referees and rejects.

Letter: Referees and rejects.


Letter: Culture-positive tuberculosis in Scotland, 1968-72.


Letter: Adverse reactions to intra-amniotic prostaglandin.


Letter: Attitudes to abortion.

Letter: Attitudes to abortion.


Letter: Threshold for oxygen pneumonitis.


Letter: Other systemic effects of eye drops.


Temporarily dependent patients in general practice.


Metoclopramide and cardiac arrhythmia.

Metoclopramide and cardiac arrhythmia.


Letter: Jaundice after halothane.

Letter: Jaundice after halothane.


Letter: Amitriptyline and imipramine poisoning in children.


Letter: Treatment of acute gout.

Letter: Treatment of acute gout.


Letter: Steroid aerosols and candidiasis.


Letter: Vein stripping.

Letter: Vein stripping.


Letter: Renal lesions of subacute infective endocarditis.


Editorial: Anaesthesia in America.

Editorial: Anaesthesia in America.


Hypotensive anaesthesia for coarctation. A method of prevention of post-operative hypertension.


Pulmonary venous admixture during one-lung anaesthesia. The effect of inhaled oxygen tension and respiration rate.


Morbidity following intravenous injections.


Letter: A hazard of blind nasal intubation.


Anaesthesia for arteriovenous fistulae: a modified stellate ganglion block.


Letter: Acupuncture analgesia.

Letter: Acupuncture analgesia.


Letter: Awareness during endotracheal intubation.


Letter: The estimation of carbon dioxide concentration in the presence of nitrous oxide.


Letter: The economics of inhalation anaesthesia.


Letter: Ketamine and pancuronium for the shocked patient.


Release of immunoreactive parathyroid hormone from rat parathyroid gland in organ culture.


Inhibition by corpora atretica of ovarian sensitivity to environmental and hormonal stimulation in the lizard, Anolis carolinensis.


Binding of T3 in rat liver nuclei.

Binding of T3 in rat liver nuclei.


Hormonal responsiveness of adenylate cyclase activity from separate bone cells.


Effects of castration and hormone replacement in fully adult male rhesus monkeys (Macaca mulatta).


Structural changes in the arginine vasopressin molecule that prolong its antidiuretic action.


The concentrations of progesterone, estrone and estradiol-17beta in the myometrium of the pregnant rabbit and their relationship to the peripheral plasma steroid concentrations.


Effects of bovine growth hormone preparations, fragments of growth hormone and pituitary anti-insulin peptide on lipolysis and glucose metabolism of isolated fat cells and adipose tissue.


Circulating LH and FSH levels and testicular function in hamsters during light deprivation and subsequent photoperiodic stimulation.


Metabolic fate of androgens in the pineal organ: uptake binding to cytoplasmic proteins and conversion of testosterone into 5alpha-reduced metabolites.


Gonad-pituitary feedback involves qualitative change: adrogens alter the type of FSH secreted by the rat pituitary.


Intracellular localization of parathyroid hormone in the kidney.


Stimulation of the peripheral metabolism of L-thyroxine and and 3,5,3'-L-triiodothyronine in the physically trained rat.


Correlation between levels of gastrin and thyrocalcitonin in pig thyroid venous blood.


On the mechansim of conversion of circulating delta4-androstene-3, 17-dione to estrone: stereochemistry of the elimination of hydrogen from ring A.


Prostaglandins A1 and A2 decrease testosterone levels in mice and rats.


Delta5-3beta-hydroxysteroid dehydrogenase activity in rat embryos on days 1 through 7 of pregnancy.


Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. A case is reported of a man who experienced hypercalcemia as a result of developing liver and renal-cell cancer.  Repeated skeletal surveys and bone scans failed to reveal any bone metastases.  The hypercalcemia was unresponsive to hydration and oral phosphate.  However, it responded immediately to oral administration of indomethacin.  The mechanism of this calcium-lowering effect is unknown.  On the death of the patient, biopsies of the metastic liver and lung tissue were performed.  The liver metastatis yielded 7 times the PGE (prostaglandin E)-like and 5 times the PGF-like material found in the normal adjacent liver.  The lung metastatis yielded only 1/2 the PGE-like and PGF-like material obtained from normal adjacent lung.  The results of this case study would indicate that some forms of hypercalcemia secondary to neoplastic disease are responsive to indomethacin and may be due to increased PG production by the tumor tissue.


Transmural myocardial infarction after exposure to carbon monoxide in coronary-artery disease. Report of a case.


Dissecting aneurysm of the aorta as an unusual cause of "asthma"--an anatomicopharmacologic correlation.


Editorial: "Closing volume" after myocardial infarction.


Editorial: Interferon inducers revisited.


Another hole in the head.

Another hole in the head.


Letter: W27 antigen and juvenile rheumatoid arthritis.


Letter: Preoperative gastric secretory studies.


Letter: Gastric emptying.

Letter: Gastric emptying.


Letter: Tumor-induced osteolysis.

Letter: Tumor-induced osteolysis.


Letter: Eye deviation in coma.

Letter: Eye deviation in coma.


Letter: Abbreviated treatment for gonococcal arthritis.


Letter: Mailed drug samples.

Letter: Mailed drug samples.


Letter: Coeval geriatric patients and specialists.


Letter: Who is a nonsmoker?

Letter: Who is a nonsmoker?


Letter: Problem-oriented vs. traditional records.


Diurnal variations in the action of insulin on muscle glycogen synthesis.


Effects of follicle stimulating hormone and luteinizing hormone on plasma testerone levels in hypophysectomized and in intact immature and adult male rats.


Plasma testosterone concentrations in the ram.


Metabolic fate of human calcitonin in the dog.


Progesterone concentration, intraluminal pressure and electrical activity of the guinea-pig uterus.


Influence of sex and age on the cortisol content of peripheral tissues and adrenal glands in the guinea-pig.


Metabolic response to male hormone and thyroid activity in the Indian garden lizard, Calotes versicolor.


Vaginal mucification in the ovariectomized rat in response to 5alpha-pregnane-3,20-dione, testosterone and 5alpha-androstan-17beta-ol-3-one: test for progestogenic activity.


Short-term variation in blood levels of prolactin, luteinizing hormone and follicle-stimulating hormone in normal men throughout the day.


Early effects of parathyroidectomy on renal retention and serum concentration of calcium in the hamster.


Proceedings: Measurement of unconjugated oestradiol-17beta in human urine by radioimmunoassay.


Proceedings: the production of antisera of high specificity to follicle stimulating hormone.


Proceedings: An electrolytic procedure for iodination of glycoprotein and protein hormones.


Proceedings: The organizing action of androgen in neonatal hamsters studied by intrahypothalamic implantation.


Proceedings: Studies on the effects of differential housing on some measures of disease resistance in male and female laboratory mice.


Proceedings: The variation in sensitivity to androgen stimulation with time after castration in the secondary sex organs of the mouse.


Proceedings: Metabolism of steroid hormones by the human mammary gland in vivo and in vitro.


Proceedings: Measurement of endogenous steroid levels in human breast tumours by mass fragmentography.


Proceedings: Studies on subcellular zinc distribution in relation to hormone levels in rat prostatic tissue using the electron microscope microanalyser, EMMA.


Proceedings: Subcellular studies of the incorporation of (35S)cysteine into components of the neurohypophysis.


Proceedings: Modifications of the redox bioassay of luteinizing hormones.


Proceedings: The characteristics of melanocyte-stimulating hormone release from incubated hemi-pituitaries of the lizard, Anolis carolinensis.


Proceedings: Relationships between intracellular potassium and steroidogenesis in isolated adrenal capsular cells.


Proceedings: Steroid involvement in calcification of the invertebrate exoskeleton.


Proceedings: Adaptation to a low calcium diet in parathyroidectomized pigs.


Proceedings: Regulation of vitamin D metabolism: factors influencing the rate of formation of 1,25-dihydroxycholecalciferol by kidney homogenates.


Proceedings: Effect of vitamin D and its metabolites on bone in tissue culture.


Proceedings: Plasma follicle-stimulating hormone and luteinizing hormone in subfertile men.


Proceedings: Plasma oestradiol and progesterone estimations in the monitoring of the induction of ovulation by human menopausal gonadotrophin and human chorionic gonadotrophin.


A controlled trial of débridement and ambulatory treatment in the management of tuberculosis of the spine in patients on standard chemotherapy. A study in Bulawayo, Rhodesia.


Hepatitis B antigen: new technics for the reduction of posttransfusion hepatitis.


Clinical correlations in alcoholic patients without manifest cirrhosis.


Chronic subcapsular hepatic bile abscess. A rare complication of percutaneous transhepatic cholangiography.


The effect of Isuprel on experimentally-induced pancreatitis in the dog.


Complications of Hirschsprung's disease in the adult.


The purification of red cells of transfusion by freeze preservation and washing. II. The residual leukocytes, platelets, and plasma in washed,freeze-preserved red cells.


Femoropoliteal bypass graft patency: An analysis of 156 cases. Patency rates were unrelated to severity of ischemia, to runoff, to presence of diabetes, and to diameter of vein in 156 femoropopliteal bypass grafts with saphenous vein followed from 9 to 106 months.


Critical arterial stenosis: a theoretical and experimental solution. The mechanics of critical stenosis of a blood vessel are studied by means of a comprehensive theoretical model in terms of energy changes and dissipation. These theoretical assumptions correlate well with experimental data obtained in vivo. Previous work in this field is analyzed. This new treatment of the phenomenon of blood vessel stenosis allows explanation of apparent contradictions in previous studies. When the velocity of flow in the unstenosed portion and the geometry of the stenosis are known, the drop in pressure at flow can be predicted.


Chemical specifications for adenine for medical use.


Acute hemorrhagic pancreatitis and pseudocyst due to mumps. This is the first reported case of mumps hemorrhagic pancreatitis in a child, documented at operation, and by rising mumps titers and complicated by a pseudocyst. In severe cases when surgery is indicated, drainage of the lesser sac usually prevents pseudocyst formation. If a pseudocyst occurs, drainage is required to eliminate disabling pain and chronic pancreatitis. Live attenuated mumps vaccine may eliminate this source of pancreatitis from American children in the future.


Transfusion of the neonatal patient.

Transfusion of the neonatal patient.


The nature and significance of hyperamylasemia follwing operation. Total serum amylase activity was found to be significantly elevated postoperatively in 11 (10%) of 110 patients undergoing various surgical procedures. Isoamylase analysis revealed that the rise was chiefly in the pancreatic-type isoamylase in seven of the 11 patients showing postoperative serum amylase elevations; in the other four patients, the elevation occurred principally in the salivary-type isoamylase. These data demonstrate that postoperative hyperamylasemia occurs surprisingly often and that serum amylase activity may rise even when the surgical procedure is extra-abdominal. Moreover, elevation of serum amylase activity after surgery is not necessarily an indication of pancreatitis and may reflect instead a rise in salivary-type isoamylase.


Jaundice and hepatitis B antigen-antibody in hemophilia.


Storage rejuvenation, and restorage of human cells for periods up to 56 days.


Effects of centrifugation on erythrocytes.


Blood flow during obstruction to the venous effect of portacaval transposition on hepatic outflow from the canine liver. When portacaval transposition (PCT) was performed in dogs in combination with a complete hepatic venous outflow block (COB) procedure, estimated hepatic blood flow (EHBF) declined steadily. Four weeks after this combined procedure mean flow was only 46% of the value obtained 3 days after operation, but this did not prevent the development of ascites which occurs in dogs with COB alone. Complete reversal of portal flow was demonstrated in the longest surviving dog. When PCT was performed in dogs with established partial outflow block EHBF remained at preoperative levels whether portal hypertension was present or not prior to the second operation. This maintenance of hepatic blood flow was due to continuing venous flow into the portal bed. It would appear that PCT is probably of little value as a treatment for portal hypertension and bleeding oesophageal varices in cases of advanced cirrhosis, but may be of some benefit in a few selected cases where the hepatic lesion is less severe.


Burn scar carcinoma and hypercalcemia.

Burn scar carcinoma and hypercalcemia. A case of a patient with burn scar carcinoma of an extremity associated with hypercalcemia and without bone metastasis is presented. From the data presented, it seems reasonable to assume that this squamous cell carcinoma of a burn scar secreted some type of parathyroid hormone-like substance or substances which posessed calcium-increasing biological activity resulting in hypercalcemia.


Reversal of capillary stasis and prevention of necrosis in burns. It has been suggested that the ultimate depth of burn necrosis might be minimized by prevention or reversal of the progressive capillary stasis which occurs in the early postburn hours. To study the role of wound dehydration in determining burn depth, 5% body surface area, 75 C, 10 second burns (in which the zone of stasis included the full thickness of skin) were inflicted on the backs of guinea pigs and subsequent mechanical trauma was prevented. At various times postburn, water content, (and after India ink perfusion) depth of capillary stasis and histological structure of burn were studied in the following groups: 1) blister intact; 2) blister removed; and 3) blister replaced by several different types of dressing. Reversal of capillary stasis was least and necrosis full-thickness in depth in undressed wounds with blister removed. Reversal of capillary stasis was complete and necrosis absent with blister replaced by fresh split-thickness porcine skin and correlated with prevention of wound dehydration. Similar, though less complete, prevention of necrosis occurred with blister intact or replaced by sialastic film. Other dressings were associated with deep necrosis or gross infection. These and other data suggest that in the zone of stasis, capillary stasis may be reversed and necrosis avoided by appropriate prevention of wound dehydration. Clinical correlations are suggested.


The effect of long-term in vitro incubation on the intermediates of red cell metabolism.


The effect of ascorbate and dihydroxyacetone on the 2,3-diphosphoglycerate and ATP levels of stored human red cells.


Ectopic drainage of the common bile duct. Two patients are presented with ectopic drainage of the common bile duct, one entering the stomach and the second entering the first portion of the duodenum. They make the seventh patient with the common bile duct entering into the stomach and the 19 patients with anomalous drainage into the duodenum. The awareness of this and other biliary system anomalies is stressed to prevent damage to vital structures in this area. The theories explaining this anomalies are discussed.


Editorial: Fiscal fumbling and budgetary bumbling.


Atypical fibromuscular hyperplasia involving the carotid artery. A case of atypical fibromuscular hyperplasia involving the carotid artery in a 38-year-old male is described. The lesion, with associated intimal disruption and subintimal hematoma, caused cerebral embolus and transient neurologic dysfunction. Segmental resection and autogenous graft reconstruction of the carotid artery were successful in removing the lesion and preventing subsequent symptoms.


Use of the umbilical vein to study the splanchnic and portal beds in shock and trauma: II. Metabolic studies. Perumbilical portal vein catheters and arterial and central venous catheters were inserted in 16 patients recovering from trauma or other shock-producing events, and in 5 patients who later developed shock. This permitted serial measurement of blood gases, pH, and the levels of ammonia, lactate and certain other metabolites in all three circulatory systems simultaneously. Nine of the trauma patients were never in shock, had no liver disease or injury and consequently formed a baseline group for comparison with the shock patients. In the shock patients there was a significant degree of hypoxemia in the portal venous blood and an increase in the arterialportal oxygen saturation difference. Their portal venous blood showed a lower pH and a higher pCO(2) than did the portal blood of the patients who had never been in shock. In 3 of the 4 shock patients who died, the total blood lactate showed a greater increase in portal venous than in the arterial or central venous blood. In shock there was also an increase in portal venous blood ammonia which was later accompanied by increments in arterial and central venous blood ammonia. This suggests impairment of hepatic urea synthesis, allowing escape of ammonia through the liver. These phenomena, when added to the finding previously reported of an elevated portal venous pressure in some shock patients, lend support to the hypothesis that in certain cases of shock there is increased impedance to flow of portal blood through the liver with resultant stasis in the portal-splanchnic bed and ischemichypoxic hepatocellular injury.


Abducting nystagmus in the medial longitudinal fasciculus (MLF) syndrome- internuclear ophthalmoplegia (INO).


Suppression of plasma cortisol in normal and glaucomatous patients.


The ophthalmetron. A clinical trial of accuracy.


Further evaluation of a latex agglutination test for detection of hepatitis B antigen.


Hematologic parameters and transfusion: WEEKLY SUMMARY BY COMPUTER.


Bulbar-pressure tests. Comparison of data obtained with anterior, lateral, and posterior compression of the eyeball.


Ultrastructural study of argyrosis of the cornea and conjunctiva.


Meningiomas of the tuberculum sellae and planum sphenoidale. A review of 83 cases.


The preparation of cryoprecipitate in a mobile laboratory: A five-year experience.


Hemoglobin SC retinopathy and fat emboli to the eye. a light and electron microscopical study.


Spontaneous expulsive choroidal hemorrhage.


Intraocular injection of gentamicin. Toxic effects of clearance.


Photodynamic inactivation of herpes simplex keratitis.


Techniques of ocular pulse analysis in carotid stenosis.


Bilateral internuclear ophthalmoplegia after trauma.


A full-field system for clinical electroretinography.


The "tomatoe-catsup" fundus in Sturge-Weber syndrome.


Letter: Sudoriferous cyst.

Letter: Sudoriferous cyst.


Natural history of male psychological health. II. Some antecedents of healthy adult adjustment.


Abstract and concrete thinking in schizophrenia during the prechronic phases.


The prediction of outcome in schizophrenia. II. Relationships between predictor and outcome variables: a report from the WHO international pilot study of schizophrenia.


Central dopamine turnover in schizophrenic syndromes.


A family interview study of male manic depressives.


State-dependent (dissociative) effects of marihuana on human memory.


Long-term use of marihuana and the development of tolerance or sensitivity to delta9 tetrahydrocannabinol.


Patients evaluate therapists.

Patients evaluate therapists.


Repeat administration of marihuana smoke to humans.


Naikan, Morita, and Western psychotherapy.


Animal model of human disease: hereditary fructose intolerance.


Interstitial pulmonary edema following bromocarbamide intoxication. Bromocarbamides are sleep-inducing drugs which can lead, in man, to intoxication and death due to respiratory failure. To prove whether hemodynamic factors or the changed endothelial permeability induce pulmonary edema, animal experiments were performed. The fine structural changes in pulmonary edema in rabbits were observed at 60, 90 and 120 minutes after oral administration. The major findings were a) large blebs between capillary endothelium and alveolar epithelium and b) interstitial edema of the vessel wall. The bleb contents were much less electron dense than the blood contents in the capillary. Colloidal carbon did not enter the bleb or the edematous interstitial tissue. Exogenous peroxidase uptake in pinocytotie vesicles increased in pathologic cases. The hemodynamic measurements in animal receiving artificial respiration which maintained the blood pO(2) at a steady state showed similar blebs in the pulmonary vessels, indicating that anoxia is not the major cause of the vascular lesion. Moreover, pulmonary arterial pressure and pulmonary vascular resistance could be held in the normal range in artificially respirated animals under bromocarbamide intoxication. Thus, hemodynamic factors are not likely to play a pathogenetic role in bringing about pulmonary edema. The chief, early factor is the increased endothelial permeability due to increased cytoplasmic transport. From this a practical suggestion for treating patients with bromocarbamide intoxication is derived: the usual fluid replacement in shock patients should be handled with great care to avoid fluid overload of the lung.


Breakdown of nonmitochondrial aspartate transaminase from pig heart in piglets.


Smooth muscle cell regeneration in repair of gastric anastomosis in the dog.


Diuretic activity in human urine: lack of action on proximal tubule and frog skin sodium transport.


Fructose induced hyperuricemia. Effects of fructose on the de novo synthesis of adenine nucleotides in the liver and skeletal muscles of rats.


A model for exposure to a semi-infinite cloud of a photon emitter.


A method for the calculation of beta-ray dose.


Neutron and photon flux from x-ray fluorescent thyroid scanners.


Use of 129I for exposure rate calibration of x-ray instrumentation.


Rationale for radiation protection.

Rationale for radiation protection.


Variations in LD50-30 in a strain of rats over 20 years.


Turnover of zinc-65 in oysters.

Turnover of zinc-65 in oysters.


Distribution and removal by DTPA of injected 252Cf in the rat.


Studies on the binding capacity of skeletal muscle constituents for cesium-134.


International comparison of measurement precision of personal exposures to ionizing radiation.


Health physics salaries.

Health physics salaries.


Measurement of x-ray quality using TLD.

Measurement of x-ray quality using TLD.


Letter: On the theory of lung deposition of very small H2O-H2SO4 aerosols.


Letter: "Fact, fashion and-or fantasy in fast neutron personnel dosimetry".


Letter: TLD transit dose.

Letter: TLD transit dose.


Cardiac rhythm and urinary excretion of catecholamine under mental work and physical exercise.


Passive transfer of the resistance to tumor with RNA.


Distribution of maltose intravenously administered to rabbits and its metabolism in the kidney.


Decrease in serum diphenylhydantoin levels after withdrawal of phenobarbital in epileptics treated with both drugs.


Serum levels of diphenylhydantoin and phenobarbital in epileptic children receiving diphenylhydantoin, phenobarbital and-or mysoline.


Physiological properties of the microvibration of the skin surface of the upper eyelid.


Arachnoid villi in the spinal cord of dasyvoid marsupials.


Synaptic organization in the dorsal cochlear nucleus of the cat: a light and electron microscopic study.


Coexistence of rigid crystalline and liquid crystalline phases in lecithin-water mixtures. X-ray diffraction measurements show that the beta'-crystalline to liquid crystalline transitions of dipalmitoyl lecithin-water mixtures take place over temperature ranges of several degrees, and by the gradual disappearance of one crystalline state accompanied by the gradual appearance of the other. The narrowness of the low angle X-ray lines indicates that the two crystalline states exist in separate phases. At a given temperature, the liquid crystalline phase has the greater water content. The bilayers of the liquid crystalline phase are thinner than those of the beta'-crystalline phase while the distances between bilayers are essentially equal in the two phases.


Dynamic local distensibility of living arteries and its relation to wave transmission. The dynamic local distensibility of the abdominal aorta was measured in 11 anesthetized dogs by recording simultaneously phasic pressure and instantaneous intravascular cross-sectional area, utilizing a special transducer. Axial motion of the vessel wall was recorded using a modification of the same transducer. A nonlinear relationship was found to exist between area and pressure in most cases studied. Fourier analysis was performed on data from eight experiments in order to obtain frequency characteristics of distensibility. In roughly half of the cases, Fourier analysis revealed that pressure variations displayed a phase lead over area variations for frequencies up to 10 Hz. This phenomenon was ascribed to viscoelastic properties of the vessel wall and the magnitude of the phase leads roughly matched those found in vitro by others. The behavior of the vessel wall in these instances was correctly predicted by the dynamic formula for distensibility, derived by others from wave transmission theory in which absence of axial wall motion is assumed. In these experiments, axial motion of the wall was found to be virtually absent. In the other half of the cases, the reverse situation was obtained: a phase lead of area variations over pressure variations for frequencies up to 15 Hz. In those cases a craniocaudal axial displacement of the vessel wall was observed with each systole, amounting to around 1 mm. The finding of the phase leads was partially explained by a dynamic formula for distensibility, developed by us from the theory of wave transmission in which free axial motion of the wall is a chosen boundary condition. The sign and order of magnitude of the phase leads were correctly predicted by the theoretical formula, but there was a disagreement on the frequency range in which they occurred. We concluded that additional forces, not yet considered in theoretical treatments, are operative on the aortic wall, which account for this lack of agreement. The frequency dependent properties of distensibility in vivo cannot be compared to those obtained in vitro in those cases in which there is axial displacement of the vessel wall of the same order of magnitude as the radial extensions.


A comparison of individual units of an artificial mastoid.


Concentration polarization in an ultrafiltering capillary. Concentration polarization, the accumulation of retained solute next to an ultrafiltering membrane, elevates osmotic pressure above that which would exist in the absence of polarization. For ultrafiltration in a cylindrical tube, use of the radially averaged solute concentration results in an underestimate of osmotic pressure, yielding an effective hydraulic permeability (k) less than the actual membrane hydraulic permeability (k(m)). The extent to which k and k(m) might differ in an ultrafiltering capillary has been examined theoretically by solution of the momentum and species transport equations for idealized capillaries with and without erythrocytes. For diameters, flow velocities, protein concentrations and diffusivities, and ultrafiltration pressures representative of the rat glomerular capillary network, results indicate that the effects of polarization are substantial without erythrocytes (k/k(m) = 0.7) and persist, but to a lesser extent, with erythrocytes (k/k(m) = 0.9), the reduction in polarization in the latter case being due to enhanced plasma mixing. In accord with recent experimental findings in rats, k is found to be relatively insensitive to changes in glomerular plasma flow rate.


Five years of experience with electric response audiometry.


Dysarthria in Wilson's disease.

Dysarthria in Wilson's disease.


Pure-tone thresholds and word-recognition abilities of hearing-impaired children.


Auditory-motor formant tracking: a study of speech imitation.


Pure-tone octave masking in normal-hearing listeners.


Pure-tone octave masking in listeners with sensorineural hearing loss.


Predicting audiovisual consonant recognition performance of hearing-impaired adults.


Linguistic performance of hard-of-hearing and normal-hearing children.


Effects of low-pass filtering on the rate of learning and retrieval from memory of speech-like stimuli.


Perception of the duration of a silent interval in nonspeech stimuli: a test of the motor theory of speech perception.


Body inversion and the acoustic immittance of the ear.


Biological ion exchanger resins. IV. Evidence for potassium association with fixed charges in muscle and brain by pulsed nuclear magnetic resonance of 39K.


A physical theory of acupuncture anesthesia.


13C magnetic resonance studies of hemoglobin carbamylation.


N-monacetylcystine in human urine.

N-monacetylcystine in human urine.


Body build and sleep-related growth hormone secretion.


Effect of thyroid status on glycerol metabolism in adipose tissue of fasted male rats.


Effect of postnatal malnutrition on plasma proteins and growth hormone in the rat.


Effect of ovariectomy on tritiated thymidine incorporation into DNA of 'non-target' organs of the mouse.


Separation of multiple forms of protein-bound metabolites of the carcinogenic hydrocarbons 3-methylcholanthrene and 7,12-dimethylbenz(a)anthracene from several rodent species.


Strain differences in the induction of soluble and microsomal enzymes by phenobarbital and 3-methylcholanthrene.


Effects of thallium (I) on the structure and functions of mammalian ribosomes.


The connections between horizontal cells and photoreceptors in the retina of the cat: electron microscopy of Golgi preparations.


A radioautographic study of the efferent pathways of the nucleus locus coeruleus.


Axanol proliferation following lesions of cerebellar peduncles. A combined fluorescence microscopic and radioautographic study.


The effects of age upon the main nucleus of the inferior olive in the human.


Differences in membrane structure between excitatory and inhibitory components of the reciprocal synapse in the olfactory bulb.


Differences in membrane structure between excitatory and inhibitory synapses in the cerebellar cortex.


Personnel and environmental thermoluminescent dosimetry for a university reactor located in a semitropical area.


Environmental and radiological monitoring at the National Reactor Testing Station during FY-1973 (July 1972-June 1973).


ERAMS Surface and Drinking Water Components, July-September 1973.


Radioactivity in airborne particulates and precipitation.


Environmental levels of radioactivity at Atomic Energy Commission installations. 1. Rocky Flats Plant, January-December 1971. 2. Sandia Laboratories, January-December 1971. 3. Stanford Linear Accelerator Center, January-December 1971.


Ethology and stress diseases.

Ethology and stress diseases.


Leukemia: much is known, but the picture is still confused.


Auditory membrane vibrations: measurements at sub-angstrom levels by optical heterodyne spectroscopy. We describe an optical technique for measurement of mechanical vibrations in the auditory organs of living animals. The technique uses light scattered from the vibrating structure and offers several new advantages. Better than 1 angstrom sensitivity, 10 micrometers spatial resolution, and > 70 decibels dynamic range are achieved. Illustrative measurements of the mechanical response of the tympanic membrane of crickets (Gryllidae) are reported.


Photochemical activity of single chloroplasts recorded by the use of nuclear track emulsion. The photochemistry done by single chloroplasts can be measured when the chloroplasts are embedded in nuclear track emulsion. It has been known for more than 50 years that certain chemicals will blacken photographic plates (chemical fogging). Although this effect has been little used to measure chemical reactions, it may be particulary useful in photochemistry and electrochemistry, since as little as 10(-18) mole can be measured.


Testosterone induces "splitting" of circadian locomotor activity rhythms in birds. Under the influence of testosterone, the free-running circadian rhythm of locomotor activity of the starling, Sturnus vulgaris, tends to "split" into two components which temporarily run with different circadian frequencies: "splitting" occurred in intact birds whose testes grew, and in castrated birds that were injected with testosterone. Since "splitting" most probably reflects the temporal separation of two (or two groups of) circadian oscillators, these results suggest that testosterone affects the mutual coupling of circadian oscillators controlling locomotor activity.


Chloride spike: a third type of action potential in tissue-cultured skeletal muscle cells from the chick. In addition to sodium and calcium spikes, tissue-cultured skeletal muscle cells from the chick can initiate spikes lasting tens of seconds. The peak membrane potential of the spike correlates with the chloride ion concentration, but not with the calcium or sodium ion concentration. The chloride spike is blocked by manganese ion but not by cobalt ion.


An improved method for the preparative isolation of the S-carboxymethyl derivative chains of human fibrinogen.


Purification and resolution of the optical isomers of labeled tryptophan metabolites on powdered paper columns.


A rapidly assembled liquid chromatography column.


The collection and elution of radioactive fatty acid methyl esters during quantitative gas-liquid chromatography.


Isolation of mycoplasmas from boar semen.


Scrapie: observations on a field outbreak.


Field studies on the epidemiology of mixed strongyle infection in the horse.


Photoelectron quantum yields of the amino acids. The photoelectron quantum yields of 21 common amino acids and 15 polyamino acids were measured in the 180-240 nm wavelength region. On the average, the quantum yields of these two groups exhibit quite similar wavelength dependence. For lambda > 220 nm all amino acid and polyamino acid quantum yields are </=10(-7) electrons/(incident) photon. The mean yields increase to about 5 x 10(-7) electrons/photon at 200 nm and 5 x 10(-6) electrons/photon at 180 nm. L-tryptophan, L-tyrosine, and poly-L-tryptophan exhibit above average yields between 180 and 200 nm. Comparison with the dye phthalocyanine indicates that the quantum yield of the dye is two orders of magnitude greater than that of the amino acids from 200 to 240 nm, suggesting the feasibility of photoelectron labeling studies of biological surfaces.


Letter: Reply to "Comments on electrical fluctuations associated with active transport".


Derivation of a quantitative kinetic model for a visual pigment from observations of early receptor potential. A "complete" and quantitative kinetic model for the states and transitions of the barnacle visual pigment in situ has been constructed from intracellular recordings of the early receptor potential responses to long light pulses. The model involves two stable and four thermolabile states and 10 photochemical, thermal, and metabolic transitions among them. The existence of each state and transition is demonstrated by qualitative examination of the response resulting from a carefully chosen experimental paradigm (combination of intensity, duration, and wavelength of adaptation and stimulation). Quantitative examination of the same responses determines all of the model transition rates, but only puts constraints on the state dipole moments. The latter are determined, and the former refined, by quantitative comparison of the predictions of the complete model with the responses to a set of paradigms chosen to involve as many states and transitions as possible. The fact that good fits can be obtained to these responses without further modification of the model supports its completeness.


Letter: Fluid flow through small pores.

Letter: Fluid flow through small pores.


Ultrastructural studies on sporulation in wild-type and white colony mutants of Streptomyces coelicolor.


Lysis induced by sodium ion and its relation to lytic enzyme systems in Clostridium saccharoperbutylacetonicum.


Studies on the formation of bacitracin by Bacillus licheniformis: effect of glucose.


Genetic analysis in a melanin-producing streptomycete, Streptomyces glaucescens.


Microbial metabolism of alicyclic hydrocarbons. Growth of Nocardia petroleophila (NCIB9438) on methylcyclohexane.


Lack of malyl-CoA lyase in a mutant of Pseudomonas AM1.


Pulmonary embolism.

Pulmonary embolism.


Factor VIII international units and reference materials.


The corrective effect of Factor VIII-coated red blood cells in haemophilic plasma with antibodies to Factor VIII.


The effect of major surgical procedures on plasma and platelet levels of Factor XIII.


The effect of staphylocoagulase on the subunit structure of human fibrin.


Experimental model of pulmonary thrombosis in rat.


The relationship between platelet aggregation and time interval after venepuncture.


Human blood platelets accumulate radioactivity from the dipeptides 14C-glycylglycine and 14C-glycylproline.


Platelet metabolism in alcohol-related thrombocytopenia.


Studies on the shape change in rabbit platelets induced by adenosine diphosphate or several metabolic inhibitors.


Influence of transient hypoxia and reoxygenation on the pre-ejection period of the heart.


Supraclavicular catheterization of the superior vena cava.


Reticuloendothelial function under general anaesthesia.


Anesthesia for Cesarean section. I. Effects on the respiratory adaptation of the newborn in elective Cesarean section.


Malignant hyperthermia in a family: a clinical and serological investigation of 139 members.


Corpus cavernosum penis pressure and penile muscle activity in the bull during coitus.


Experimentally induced rupture of corpus cavernosum penis of the bull.


Weight changes of rhombencephalon and eye lens in the developing bovine fetus.


The mental health services: a review of the statistical sources and a critical assessment of their usefulness.


Transmission of swine dysentery with Treponema hyodysenteriae and Vibrio coli.


Two syndromes of suicide.

Two syndromes of suicide.


What shall we do with the drunkenness offender?


A clinical and family comparison of paranoid and non-paranoid schizophrenics.


The stability of psychiatric diagnosis.

The stability of psychiatric diagnosis.


The reliability of the psychiatric anamnesis.


Personality disorder. II. Follow-up.

Personality disorder. II. Follow-up.


A token economy project with chronic schizophrenic patients.


X-ray screening for industrial populations.


An experimental investigation of desensitization in phobic patients.


"Are medical ethical practices sufficient in industrial medicine?".


Epidemiologic survey of leukemia in persons potentially exposed to benzene.


Potash ore and perforation of the nasal septum.


The employee wearing a cardiac pacemaker.


An outbreak of chimpanzee associated hepatitis.


Hypertension screening and follow-up.

Hypertension screening and follow-up.


Criteria for a recommended standard--occupational exposure to sulfur dioxide.


Teaching employees to be "defensive drivers".


To the evolution of natural foci of L. grippotyphosa in Central Europe.


Siphonaptera from eastern Afghanistan.

Siphonaptera from eastern Afghanistan.


Entomogenous fungi associated with the tick Ixodes ricinus (L.).


The muskrat as reservoir in natural foci of adiaspiromycosis.


Cutaneous staphylococcosis and secondary infection of house sparrow with the fungus Cladosporium herbarum.


A skin-testing survey with toxoplasmin on positivity in the different age- and sex groups of the normal urban population of Kaduna (Nigeria).


Limax amoebae in five swimming pools in Stockholm.


Description of Hirstionyssus pavlovskyi sp. n. (Acari: Dermanyssidae) collected from Dryomys nitedula in the Pirin Mountains, Bulgaria.


Sokoloviana pavlovskyi sp. n., a new mite species from the semipalmated plover from Cuba (Analgoidea, Pterolichidae).


Leptopsylla taschenbergi calamana Jordan, 1951 and some other findings of fleas (Insecta, Siphonaptera) in Switzerland.


Some features of the developmental cycle of the tick Ixodes ricinus (L.) (Acarina: Ixodidae).


Notes on the differentiation of Capillaria hepatica and visceral larva migrans.


Degradation of 2,4-dihydroxyquinazoline by a soil Micrococcus.


'Finger-print' analysis of cell wall proteins from different yeast species after trypsinization.


Non-visual light responsiveness in the pigeon: developmental and comparative considerations.


Development of the rat salivary glands. 3. Mesenchymal specificity in the morphogenesis of the embryonic submaxillary and sublingual glands of the rat.


Surgical approach to the dolphin's ear.

Surgical approach to the dolphin's ear.


Development of lethal yellow (Ay-Ay) mouse embryos in vitro.


Calls of different individual hens and the parenteral control of feeding behavior in young Gallus gallus.


The inhibitory effects of concanavalin A on the development of the amphibian embryo.


Influence of hypophysectomy and starvation on blood glucose levels in the newt, Notophthalmus viridescens.


The search for a relationship between phenothiazine drug metabolism and clinical effectiveness.


The molecular structures of phenothiazine derivatives.


Quantum chemical and other theoretical techniques for the understanding of the psychoactive action of the phenothiazines.


Direct, multiple ion detection of chlorpromazine by mass fragmentography.


Imipramine and chlorpromazine in hepatic microsomal systems.


Some aspects of the in vitro oxidation of 35S-chlorpromazine.


Effect of phenothiazine drugs on the stability of rat liver subcellular particles.


Factors predisposing to drug-induced neurologic effects.


Effects of promazine and chlorpromazine metabolites on the cornea.


Further studies of chlorpromazine metabolism in schizophrenic men.


Quantitation of chlorpromazine and its metabolites in human plasma and urine by direct spectrodensitometry of thin-layer chromatograms.


Chlorpromazine analysis by gas chromatography with an electron-capture detector.


Total excretion of 3H-chlorpromazine and 3H-prochlorperazine in chronically dosed animals: balance sheet.


High-pressure chromatographic analysis of phenothiazine-related compounds.


Immunological properties of some phenothiazines.


Pharmacokinetics of chlorpromazine metabolites--a colossal problem.


The inhibition of the uptake of monoamines by blood platelets by phenothiazines and other drugs.


Two types of metabolically produced trifluoperazine N-oxides.


Imipramine protein binding and pharmacokinetics in children.


Metabolic and clinical observations on metiapine in humans.


Imipramine steady-state studies and plasma binding.


Thiothixene and the thioxanthenes.

Thiothixene and the thioxanthenes.


Phototoxicity and chlorpromazine photochemistry.


Activation of L-amino acid oxidase by phenothiazines: thermodynamic and physical chemical studies.


Studies on the metal chelation of chlorpromazine and its hydroxylated metabolites.


Behavioral, biochemical, and pharmacological effects of chronic dosage of phenothiazine tranquilizers in rats.


Effects of hydroxylated phenothiazine metabolites on rat brain mitochondria.


Pharmacological and behavioral effects of mono- and disubstituted chlorpromazine derivatives.


Antipsychotic efficacy of clozapine in correlation to changes in catecholamine metabolism in man.


Prediction of neuroleptic effects from animal data.


Induction of increased aryl hydrocarbon hydroxylase activity by phenothiazines.


Effects of chlorpromazine on acetylcholine turnover in vivo.


Interactions of chlorpromazine with monoamines in the hypothalamic thermoregulatory centers.


Gas chromatographic studies on basic nitrogenous drugs. I. Addition of basic compounds or steam to the carrier gas.


Sephadex G-25 beads as chromatographic carrier for the fractionation of animal cells.


Affinity chromatography of triton-solubilized brain acetylcholinesterase.


An improved technique for the analysis of amino acids and related compounds on thin layers of cellulose. IX. The characterization of some histidyl, prolyl and lysyl dipeptides by thin-layer and ion-exchange chromatography.


Studies on the heterogeneity of hemoglobin. XVI. Separation of variants with a GlU-Lys substitution by chromatography on CM-cellulose.