A study of free radicals occurring in tumorous female breast tissue and their implication to detection.


The antiarrhythmic properties of lidocaine and propranolol: a review.


Function of gene 32-protein, a new protein essential for the genetic recombination and replication of T4 bacteriophage DNA.


Escherichia coli RNA polymerase: purification, subunit structure, and factor requirements.


Endocrine properties and mechanism of action of oral contraceptives.


Tissue culture of human renal cell carcinoma: effect of serum on monolayer growth.


Tissue typing for transplantation: a progress report.


New approach to the treatment of bone disease with fluoride.


Assessment of function in the transplanted kidney with 131-I hippuran.


Ribonucleic acid polymerase and the synthesis of RNA in mammalian cells.


Hypospadias: a review of repairs in 78 pre-school children.


Clinical pharmacological trial of loxapine succinate.


Oral contraceptives: a review of certain metabolic effects and an examination of the question of safety.


Recent advances in thyrocalcitonin research.


Antifertility drugs. Symposium discussion. The development of antifertility drugs is reviewed and judged as beneficial to man's social progress, although the need for safer, more convenient, and more effective contraceptives is still recognized.  The unreliability and subjectivity of most reports of side effects from pill use is noted, and the need for accurate and comprehensive epidemiological studies of oral contraceptives is emphasized.


The behavioral pharmacology of oxypertine.


Dexbenzetimide in neuroleptic-induced parkinsonism. A double-blind crossover study with a 16-week follow-up.


Assessment of dosage deviation in outpatient drug research.


Regional cerebral blood flow in tumor-patients.


Calcium and magnesium absorption in the germfree rat.


Cholesterol biosynthesis in rat liver: diurnal variation and regulation by cholesterol.


Fatty acid synthesis and mitochondrial localization.


Ceruloplasmin, a link between copper and iron metabolism.


Plasma amino acids in maternal undernutrition.


Glucose, free fatty acids, and insulin secretion.


Sweetening agents.

Sweetening agents.


Lipid synthesis by the sheep intestine.

Lipid synthesis by the sheep intestine.


A physiological function for thyrocalcitonin.


Ribosome specificity of protein synthesis in vitro.


Synthetic nucleotide-peptides.

Synthetic nucleotide-peptides.


The crystal structures of purines, pyrimidines and their intermolecular complexes.


Induced activation of amino acid activating enzymes by amino acids and tRNA.


N6-(delta 2-isopentenyl)adenosine: chemical reactions, biosynthesis, metabolism, and significance to the structure and function of tRNA.


Nucleotide biosynthesis from preformed purines in mammalian cells: regulatory mechanisms and biological significance.


Aminorex fumarate: a double-blind trial and examination for signs of pulmonary arterial hypertension.


A random triple-blind study of tablets penicillin VK, injection Penilente Forte and injection bicillin L-A in prophylaxis of tonsillitis.


Anaesthesia for renal transplantation. A preliminary report.


Dr James Barry, controverisal South African medical figure: a recent evaluation of his life and sex.


Psychoactive drugs in the immature organism.


Clinical and research applications of a new elastic cohesive bandage.


A study of quinacrine dihyochloride in the human breast in vitro and in vivo.


Endocrine disease and anaesthesia. A review of anaesthetic management in pituitary, adrenal and thyroid diseases.


Determination of hyaluronic acid in the microgram range.


Fat embolism.

Fat embolism.


The 24-year feud between Edward Lawrie, "chloroformist", and Walter Gaskell, "physiologist".


Atlantic-Cape May County Dental Society membership 1970.


1970 membership list.

1970 membership list.


Bridges in practice. 3.

Bridges in practice. 3.


Oral tissue transplants: autogenous, homologous and pedicle.


Care of high speed equipment in dentistry.


On the relationship between aggressive activation, symbiotic merging, intactness of body boundaries, and manifest pathology in schizophrenics.


In memoriam; Dr. Hugo Spatz.

In memoriam; Dr. Hugo Spatz.


Studies on fundamental and practical factors in dental casting. I. Casting time.


Studies on fundamental and practical factors in dental casting. II. Solidification time.


Studies on fundamental and practical factors in dental casting. 3. Procedures for determining practical casting conditions.


The measurement of serum gastrin.

The measurement of serum gastrin.


Theoretical survival curves for radiation damage in bacteria.


Control of gene function in baceriophage T4. II. Synthes of messenger ribonucleiccid and proei after interrupting deoxyribonucleic acid replication and glucosylation. Replication of T4 deoxyribonucleic acid (DNA) is known to be required for the onset of transcription of late T4 genes. Once late gene transcription has been initiated, DNA replication is no longer required for maintaining synthesis of late or early T4 messenger ribonucleic acid (mRNA). Late phage proteins (lysozyme and tail fibers) continue to be produced at constant rates after interrupting T4 DNA synthesis. The ability of the host cell to glucosylate the T4 progeny DNA has no demonstrable influence on the rates at which T4 mRNA and late proteins are synthesized after the interruption of DNA synthesis. To explain the requirement of T4 DNA replication for the onset of late gene transcription, we suggest that T4 DNA in a nascent state is mandatory for the initial late gene transcription, or perhaps for late gene transcription throughout the lytic cycle. T4 DNA in a nascent state could be segregated from the bulk of the replicating DNA, used only as template for RNA synthesis, and prevented from being modified by methylation, glucosylation, or maturation processes. The fact that no, or very little, nonglucosylated T4 DNA is extractable from T4LB3-infected CR63 after arresting DNA synthesis does not rule out this possibility.


Glottic reconstruction after hemilaryngectomy.


Historic hospitals. The Royal Hospital of New Orleans during the Spanish period.


Who follow a gleam. Leopold Auenbrugger.


Inhibition of tumorigenesis.

Inhibition of tumorigenesis.


Importance of animal genetics in the testing of drugs and foods.


Hepatic changes in various lipidoses: electron microscopic and histochemical studies.


Liver disease in India.

Liver disease in India.


Contraceptive technology: advances needed in fundamental research.


Endotoxin: stimulation of bone resorption in tissue culture. Bacterial endotoxins can stimulate the release of previously incorporated calcium-45 and tritiated proline from fetal rat bone in tissue culture. Endotoxin from Bacteroides melaninogenicus, an organism regularly found in the gingival crevice of man, produces a response similar to parathyroid hormone and is effective at doses as low as 0.1 microgram per milliliter. This response is inhibited by serum and dependent upon the presence of albumin. Endotoxins may play a role in the bone loss characteristic of human periodontal disease.


Genetically altered tRNA-Gly subspecies in E. coli.


The speed and order of colonisation of some organs of anaemic mice of the & series transplanted wth allogeneic haemopoietic tissue.


Pemphigus and other diseases. Results of indirect intercellular immunofluorescence.


Dermatitis herpetiformis in an infant.

Dermatitis herpetiformis in an infant.


The rennin-sensitive bond of bovine kappa-casein.


Plasmolysis and bacterial motility: a method for the study of membrane function.


The non-simultaneous dissociation and loss of activity of beta-galactosidase in urea.


Conformational change and behavior of tyrosine residues of bacterial flagella and flagellin at high pH.


Actions of steroid hormones at cellular and molecular levels.


Amino acid sequence of C-terminal fragment of hog pepsin.


Close linkage between a galactose binding protein and the beta-methylgalactoside permease in Escherichia coli.


Action of T1 ribonuclease on Escherichia coli ribosomes and their subunits.


Nucleotide sequences in a protected area of the 16S RNA within 30S ribosomal subunits from Escherichia coli.


Modification of in vitro cytotoxicity of lymphocytes from patients with chronic ulcerative colitis or granulomatous colitis for allogenic colonic epithelial cells.


Tendon healing.

Tendon healing.


Purpose and methodology in clinical trials on new drugs.


Colin Campbell Anderson.

Colin Campbell Anderson.


Alastair Gordon Couston.

Alastair Gordon Couston.


Alexander Henderson Kirker.

Alexander Henderson Kirker.


Joseph Cecil Douglas Macky.

Joseph Cecil Douglas Macky.


John Bentham Morris.

John Bentham Morris.


Photochemical reactions in amino acid residues  and inactivation of enzymes during U.V.-irradiation. A review.


Bacterial spore outgrowth: its regulation.


Motoneuron morphology and synaptic contacts: determination by intracellular dye injection. The structure and dendritic connections of an identified crustacean motoneuron were analyzed by intracellular injection of dye. Some processes of the neuron end in the ganglionic neuropil, but most terminate on axons which pass through the ganglion in specific, identifiable tracts. The former processes are ipsilateral to the soma, while the latter, as well as their connections, display bilateral symmetry. Structural and functional evidence suggests that the demonstrated contacts are synaptic junctions, and that the approach can therefore be used to study patterns of synaptic organization in complex neural networks.


Studies on partially virulent mutants of lambda bacteriophage. I. Isolation and general characterization.


Deletion mapping of the c3-c2 region of bacteriophage lambda.


Requirements for curing of lambda lysogens.


Transformationof phage T4 by small denatured DNA fragments.


Subunits of T4 head structures.

Subunits of T4 head structures.


Replication of bacteriophage lambda DNA associated with the host cell membrane.


Differential transmission of amber and wild-type alleles of bacteriophage T4 in mixedly infected cells of Escherichia coli.


Characterization of the Bacillus stearothermophilus phage phimu-4 and its DNA.


Transferable tetracycline resistance in Salmonella typhimurium and Shigella sonnei derived from resistant strains of Escherichia coli.


Occurrence of colicinogenic strains among tetracycline resistant strains of Escherichia coli.


Postoperative nausea and vomiting: A review of their incidence, causes and effects.


The termination of the cervicothalamic tract in the cat. An experimental study with silver impregnation methods.


Isolation of hamster brain astroglia by in vitro cultivation and subcutaneous growth, and content of cerebroside, ganglioside, RNA and DNA.


Long-term skin allograft survical elicited by a finite treatment with antilymphocyte serum combined with cytarabine.


Quantitative passive hemagglutination: adaptation of the cell migration technique to measurement of antibodies to protein.


Impaired recovery of plaque-forming cells in New Zealand mice given cyclophosphamide.


The localized hemolysis-in-gel method adapted to the detection of spleen cells releasing virus-specific antibodies.


Studies of antibody formation in Xenopus laevis.


In vitro detection of transplantation immunity: the inhibition of migration of immune spleen cells and peripheral blood leukocytes by specific antigen.


Factors affecting the quantitative production and assay of human leukocytic pyrogen.


Cryoglobulins. I. Studies on the nature, incidence, and clinical significance of serum cryoproteins in glomerulonephritis.


Genesis of cancer (a temporal approach).


Stanhope Bayne-Jones, M.D. (1888-1970).

Stanhope Bayne-Jones, M.D. (1888-1970).


Goodpasture's Syndrome. Case report.

Goodpasture's Syndrome. Case report.


Electrocardiographic and hematological changes by exercise test in coronary patients and pyridinolcarbamate pretreatment. A double-blind crossover trial.


Diuretic therapy--current status.

Diuretic therapy--current status.


A standard platelet suspension: control of automatic platelet counting with the Coulter counter.


Nitrite test strips for detection of nitrate reduction by mycobacteria.


Joseph Edward Campbell, M.D., 1925-1969.


Martin L. Dreyfuss, M.D., 1908-1969.

Martin L. Dreyfuss, M.D., 1908-1969.


Techniques of pulmonary resection: tradition and travail.


Pulmonary vascular resisnce following lung reimplantation and transplantatin.


Lung transplantation 1970.

Lung transplantation 1970.


Cardiac transplantation in man. VII. Cardiac allograft pathology.


Historical aspects of sarcoidosis.

Historical aspects of sarcoidosis.


Catecholamine metabolism in neuroblastoma: kinetics of conversion of 3H-3-methoxy-4-hydroxyphenylglycol to 3H-3-methoxy-4-hydroxymandelic acid.


Effects of repetitive glucose loads on plasma concentrations of glucose, insulin and free fatty acids: paradoxical insulin responses in subjects with mild glucose intolerance.


Pseudohypoparathyroidism: responsiveness to parathyroid extract induced by vitamin D2 therapy.


Effect of extended infusion of a low dose of heparin on plasma FFA levels.


Failure of FSH release by oxytocin in man.


Excystment of the metacercariae of Echinoparyphium serratum (Trematoda: Echinostomatidae).


A controlled clinical trial with indomethacin as an antipyretic in children.


Effects of oestrin-progestin and E. coli endotoxin.


Comparison of penicillinases produced by R factors isolated from ampicillin-resistant gram-negative bacteria.


Genetic recombination in Klebsiella pneumoniae. An approach to genetic linkage mapping.


Experimental Salmonellosis. Unstable L forms in liver of infected mice.


Antigenic determinants of Salmonella for production of "clearance" factor in mouse typhoid.


Differences in phospholipid composition between wild strains and streptomycin resistant mutants of certain enteric bacteria.


The seasonal transition of fecal isolations of enteropathogenic Escherichia coli from healthy milking cows.


Foster mothers and mental patients: an exploratory study of interpersonal relationships.


The romance and rodomontade of comprehensive community mental health.


Isolation of anti-polysaccharide antibodies with glutaraldehyde cross-linked lipopolysaccharides.


Current concepts: ulcerative proctitis.

Current concepts: ulcerative proctitis.


Acute renal failure due to nephrotoxins.


Lower esophageal ring. 2.

Lower esophageal ring. 2.


Pathogenesis of oliguric acute renal failure.


Specialist in applied pathology.

Specialist in applied pathology.


Buried dermal flap operation for chronic lymphedema of the extremities. Ten-year survey of results in 79 cases.


Reconstruction of the naso-orbital complex in the war casualty.


Effects of silver nitrate and sulfamylon on epithelial regeneration.


Correction of the saddle nose deformity by reconstruction of the nasal dorsum out of the chondro-osseous sidewalls of the nose.


Correction of the saddle nose deformity by reconstruction of the nasal dorsum out of the chondro-osseous sidewalls of the nose. Comments.


Single tubed pedicle in the form of a loop.


Scar repair by the double-breasted vest principle.


Acceleration of reticulum cell sarcoma in SJL mice chronically treated with heterologous antilymphocyte serum.


Immunofluorescent studies of antibodies against human malignant melanoma.


Metabolism of the autotransplanted heart.


Effects of rhythm on function and survival of the dog cardiac homotransplant.


A histochemical analysis of rejecting dog cardiac allografts.


A method of transplantation of hearts in dogs.


The reversibility of dog cardiac allograft rejection.


Effects of subclavian steal and compromised cephalic blood flow on cerebral circulation.


Late effects of anoxic arrest on cardiac contractility.


Validity of concept of increased extracellular fluid after open heart surgery.


Estimation of stroke volume from the central arterial pressure contour in postoperative patients.


Effects of parasympathetic manipulation on renal hemodynamics and function in endotoxin shock.


Sodium and sulfate distributions in dogs after hemorrhagic shock.


Intracellular enzyme behavior following soluble ribonucleic acid treatment of endotoxic shock in the dog.


Fat embolism and the postmortem interval.


Measurement of extravascular lung water in surgical patients.


Respiratory, hemodynamic, and angiographic characteristics of transplanted lungs after three to twelve months.


Effects of live Escherichia coli bacteremic shock on pulmonary hemodynamics and capillary permeability.


A simple method for continuous monitoring of cardiac output.


Effect of endotoxin on mitochondrial respiration.


Preparation and clinical use of type specific goat antihuman lymphocyte globulin.


Modification of the immunosuppressive effects of rabbit antimouse lymphocyte serum by a thymic humoral factor: thymosin.


Effect of phytohemagglutinin-P on immunosuppressive regimens in the adult dog.


Suppression of homograft immunity with thiocymetin.


A more specific rabbit antimouse lymphocyte serum.


Prediction of dog kidney allograft survival by the mixed periperal leucocyte interaction.


Serum hydroxybutyric dehydrogenase: a clinical guide to renal allograft rejection.


Cytotoxic antibody after antigen pretreatment: enhancement of renal allografts.


The relationship between immunity and tolerance.


Effect of a single large dose local x-rays on allogeneic skin graft rejection in the mouse.


Successful long term inhibition of xenograft rejection.


Xenograph prolongation by molecular coating with antigenically altered collagen.


Cardiac output determination: superiority of thermal dilution.


Hyperacute rejection of dog renal autografts.


Host repopulation of the endothelium in allografts of kidneys and aorta.


Bile secretion following orthotopic transplantation of the liver in dogs.


The failure of lyophilized skin to induce allograft immunity.


Effect of a yeast-respiratory stimulator on imuran treated and untreated dog renal allografts.


Cytotoxic antibodies following human renal transplantation.


Permanent survival of dog renal allografts after a limited course of antilymphocyte serum treatment.


Gastric secretion in the dog fetus following maternal stimulation with secretagogues.


Evaluation of radiosulfate as a measure of functional and total extracellular fluid.


A description of the course of long term surviros of dog liver replantation.


Effect of auxiliary liver transplantation on haptoglobin synthesis in the dog.


Influence of blood supply on regeneration of liver transplants.


The dog left hepatic division as an auxiliary allograft.


Effects of bilateral nephrectomy on hemodynamics and body composition in patients with chronic renal failure.


Sulphur-35 measurements of functional and total extracellular fluid in dogs with hemorrhagic shock.


Effect of salt infusion on postoperative aldosterone secretion.


Enhancement of ovarian graft survival in mature rats.


Anesthetics and the study of afferent pathways.


Influence of hemodilution perfusion on total body and intracellular potassium: critical prospective study.


Strontium-85 scintimetry in the study of skeletal complications of renal transplantation.


Bone metabolism studies in renal transplant recipients.


Tibial bone grafts in the rat: the effects of prior host sensitization, prednisolone, and azathioprine on graft incorporation.


Applications of the autotransplanted vascular-pedicled skin flap.


The pattern of rejection of dog laryngeal allografts.


New information concerning immunity in the anterior chamber of the eye.


Circulation of pedicle flaps studied by tissue clearance of 99mTc-pertechnetate.


Perfusion of isolated composite skin flaps.


Serotyping of Escherichia coli in urologic practice: therapeutic and epidemiologic implications.


Experimental renal preservation.

Experimental renal preservation.


Preoperative induction of healing in skin wounds in rats.


Repair of aortic arch interruption in the neonate.


Capillary transport function in skeletal muscle in hemorrhagic shock.


Circulating lymphocyte depletion: effect on renal allograft survival in calves.


Clinical experience of disinfection of the engström respirator by ultrasonic nebulized ethyl alcohol.


Congenital reticulum cell sarcoma of the cerebellum.


Ultrastructure of tri-ortho-cresyl phosphate poisoning in the chicken. II. Studies on spinal cord alterations.


Evaluation of phagocytosis in rickets.

Evaluation of phagocytosis in rickets.


Effects of a pathogenic canine herpesvirus on canine brain cell cultures and cerebellar explants.


Observer variability in the histopathologic diagnosis of lung cancer.


Long-lasting antituberculous activity of derivatives of 2-styrylquinoline.


How much isoniazid is needed for prophylaxis?


The section embedding (SE) technique. A new method for the combined light microscopic and electron microscopic examination of central nervous tissue.


In vitro action of polyvinylsulfate on acylation and methylation of nucleic acids.


The influence of dimethyl sulphoxide on metabolic activity of ehrlich ascites carcinoma cells and microorganisms.


Will the exploding human population succeed in conserving nature?


Computer prediction of chronic psychiatric patients.


Warren Sturgis McCulloch (1898-1969).

Warren Sturgis McCulloch (1898-1969).


Type I muscle fibre atrophy and central nuclei. A rare familial neuromuscular disease.


Lionel Wolman (1921-1969).

Lionel Wolman (1921-1969).


Long-acting thyroid stimulator: A review.


Initiator codons in eukaryotes.

Initiator codons in eukaryotes.


Sir Boris Uvarov.

Sir Boris Uvarov.


Artificial kidneys and renal transplantation.


Renal vascular volume, blood flow, and resistance in hypertension and renal arterial stenosis.


Plasma kinins.

Plasma kinins.


The application of whole-body counting to studies of the turnover of 131I-labelled plasma proteins.


Effects of physical conditioning. A hypothesis concerning circulatory adjustment to exercise.


Diurnal variations in extracellular fluid volume in man detected by constant infusion technique.


Washout of 133Xenon after intramuscular injection and direct measurement of blood flow in skeletal muscle.


Determination of mean pulmonary transit time and pulmonary blood volume by radiocardiography.


Experiences with stereotactic treatment of intractable pain.


Hyposensitisation in grass pollen hay fever. A double blind trial of alumn precipitated pollen extract and depot emulsion pollen extract compared with placebo injections.


Kidney preservation with hypothermia and hyperbaric oxygen. II. Renal clearances in pigs with autotranlanted 24-hour preserved kidneys.


Extracorporeal irradiation of the blood as immunosuppressive treatment in renal ansplantation.


Autoantibodies related to treatment with chlorthalidone and alpha-methyldopa.


A clinical evaluation of a monthly injection for conception control.


Annals of anesthetic history. Seishu Hanaoka, a Japanese pioneer in anesthesia.


The genetics of cleft lip and cleft palate.


Pulmonary mechanics during general anesthesia: V. Status asthmaticus.


Bupivacaine for peripheral nerve block: A comparison with mepivacaine, lidocaine, and tetracaine.


Spare-time biographer.

Spare-time biographer.


Serotonin: a review.

Serotonin: a review.


Benzimidazole nucleosides, nucleotides, and related derivatives.


The cradleboard of the Western Indians. A baby-tending device of cultural importance.


Why man is such a sweaty and thirsty naked animal: a speculative review.


The age of menopause in classical Greece and Rome.


Age of boys' puberty in Leipzig, 1727-49, as indicated by voice breaking in J.S. Bach's choir members.


Address by the Archbishop of York (Florence Nightingale).


Introduction: Paul Bert commemorative issue.


A study of aquatic life from the laboratory of Paul Bert. A review of "La Vie dans les Eaux" by Paul Regnard, Paris 1891.


Asa Briggs: a profile.

Asa Briggs: a profile.


Hysterography in the diagnosis of uterine myoma. Roentgen findings in 829 cases compared with the operative findings.


Transfer factor.

Transfer factor.


A double blind trial with cartilage and bone marrow extract in degenerative gonarthrosis.


Fluorescent-antibody patterns in naturally acquired vivax malaria.


Resistance of the group A streptococcal L form to sonic oscillation.


A simple method for extraction of RNA from E. coli utilizing diethyl pyrocarbonate.


Congenital syphilitic labyrinthitis.

Congenital syphilitic labyrinthitis.


Silver impregnation of bone. A useful technique in studying otosclerosis.


Continuous inverting mucosal suture forceps.


Non-magnetic intra-ocular foreign bodies (1958-1967).


In vitro metabolism of pregnenolone-7-alpha-3H, progesterone-4-14C and androstenedione-4-14C by rat placental tissue.


Effect of stage of the estrous cycle and gonadotrophins upon luteinization of porcine granulosa cells in culture.


Energy requirements for insulin release from rat pancreas in vitro.


In Memoriam Dr. Helmuth Brezowsky.

In Memoriam Dr. Helmuth Brezowsky.


Host hormones and parasitic infection.

Host hormones and parasitic infection.


The significance of bacteria in feline cystitis and urolithiasis.


Suture or tendon graft?

Suture or tendon graft?


The interaction of seryl and of leucyl transfer ribonucleic acid synthetases with their cognate transfer ribonucleic acids.


Delayed primary suture of flexor tendons cut in the digital sheath.


Characterization and gas chromatographic determination of active principles of biological interest in pharmaceutical products (gastric mucoprotein and thioctic acid).


The role of surgery in the treatment of malignant tumours of the spine.


Anti-protein plaque-forming cells detected with high efficiency by the use of red cells coupled to bovine serum globulin through bis-diazo-benzidine.


Effect of phytohemagglutinin on skin allograft survival in mice.


The doctors feud: an account of the Hill-Evans affair.


The ethics of heart transplantation.

The ethics of heart transplantation.


Dr. Robert Stewart Jason awarded Distinguished Service Medal for 1969.


Human cardiac transplantation experience and results with 21 cases.


A study of egg transport in the rabbit using a freezing-clearing technique.


Anatomy of feline esophagus with special reference to its muscular wall and phrenoesophageal membrane.


Collision lifetimes and recognition times for macromolecule synthesis.


Cardiac transplantation infour patients. Hemodynamic function in the immediate postoperative period.


Use of Pluronic F-68 to diminish fat emboli and hemolysis during cardiopulmonary bypass. A controlled clinical study.


Methods and technique of experimental autotransplantation of a lung lobe.


Loss of host-controlled restriction of lambda bacteriophage in Escherichia coli following methionine deprivation. lambda Bacteriophages produced in Escherichia coli C (designated as lambda . C) are restricted in their ability to grow in E. coli K-12. The rare successful infections that arise in the K-12 population occur in "special" cells which have lost their capacity to restrict lambda . C. These infections yield modified progeny phage (designated as lambda . K) which, unlike lambda . C, plate equally well on E. coli C and E. coli K-12. When methionine, but no other amino acid, was removed from the growth medium of a mutant strain of E. coli K-12, the number of special cells rapidly increased 500- to 3,000-fold. These new special cells retain their capacity to produce modified lambda . K progeny. This conversion of restricting cells into special cells does not require the synthesis of new protein. The special cells formed when methionine was removed from the culture did not revert into restricting cells when methionine was restored. Such cells have also lost the ability to divide for at least 4 hr after methionine supplementation. When methionine was restored, the remaining restricting cells, but not the special cells, immediately resumed growth. Removing methionine from cultures of E. coli B caused a similar increase in the number of special cells able to support the growth of lambda . C and lambda . K. However, when E. coli K-12 (P1) cultures were deprived of methionine, the number of special cells increased for lambda . C but not for lambda . K. Thus, retention of the P1-restriction system, unlike the B- and the K-12-systems, does not require the presence of methionine.


Nitrogen dioxide toxicity. Report of four cases in firemen.


Effect of infection with ribonucleic acid bacteriophage R23 on the inducible synthesis of beta-galactosidase in Escherichia coli. Infection by ribonucleic acid (RNA) bacteriophage R23 inhibited the synthesis of beta-galactosidase in Escherichia coli. The inhibition, although not complete, was apparent shortly after infection and was maximal after the first 20 min of infection. R23 diminished the beta-galactosidase-synthesizing capacity when inducer was added after phage infection, but not when infection followed inducer removal. These findings suggested that the primary effect of R23 on enzyme-forming capacity was limitation of synthesis of enzyme-specific messenger RNA. Studies with ultraviolet irradiated phage and amber mutants of R23 indicated that the inhibitory process could be separated into two phases. Early inhibition did not require the expression of the viral genome, whereas late inhibition required the expression of the viral RNA synthetase cistron.


The artificial kidney at home. A look five years later.


Albert John Ochsner(1858-1925). Chicago Surgeon.


Failure of penicillin in a newborn with congenital syphilis.


One way to be a surgeon (Christiaan Barnard).


Qualitative and quantitative histoenzymology of long surviving human renal homotransplants.


Evidence for oxytocin synthesis after electrolytic destruction f the paraventricular nucleus in rats withereditary hypothalamic diabetes insipidus.


Regulation of cholesterol metabolism. 3.


Compartmentalization of ascites and edema in patients with hepatic cirrhosis.


Measuring the urban poor's use of physicians' services in response to illness episodes.


Technics of histocompatibility testing.

Technics of histocompatibility testing.


Control of hemoglobin function within the red cell.


Acid secretion after calcium carbonate in patients with duodenal ulcer.


Some medical pioneers in New Zealand. 2.


Thomas Moore Philson.

Thomas Moore Philson.


Arthur Guyon Purchas.

Arthur Guyon Purchas.


Personality correlated of achievement imagery: theoretical and methodological implications.


Estimation of distances on the body.

Estimation of distances on the body.


A mutant of Escherichia coli with temperature-sensitive streptomycin protein. The temperature-sensitive mutation in our Escherichia coli strain C1714 appears to be in a ribosomal protein. The mutation maps at the streptomycin locus. Protein synthesis in intact cells stops immediately when the temperature is shifted from 30 to 42 degrees C. Analysis of polyribosome distributions after shift-up suggests that initiation of protein synthesis is defective at the high temperature. In vitro protein synthesis in extracts from C1714 is temperature sensitive when directed by natural mRNA, but not when directed by poly U.


Origin and direction of replication of the chromosome of E. coli B-r. The origin and direction of replication of the E. coli B/r chromosome has been determined by comparing gene frequencies in P1-transducing lysates prepared on cultures growing at different rates. The gene frequencies found are consistent with the idea that replication of the chromosome is dichotomous in rapidly growing B/r. The origin was found to be between 40 and 55 min on the E. coli genetic map with replication proceeding in a clockwise direction. Markers near the origin behaved anomalously.


Mechanics of frameshift mutagenesis in bacteriophage T4: role of chromosome tips. In contrast to observations in bacteria and fungi, frameshift mutations in bacteriophage T4 do not arise during genetic recombination. Nascent mutants, captured in the heterozygous condition, exhibit properties which indicate that the new lesions are located at the extreme tips of the chromosomes, and are segregated by a combination of recombination and replication.


Derepression of GDP-alpha-mannose and UDP-glucose pyrophosphorylases by a regulator gene mutation; episomal dominance in partial diploids. Mutants of Escherichia coli K12 at the capR locus are overproduce capsular polysaccharide, and are derepressed for synthesis of several enzymes involved in capsular polysaccharide synthesis(1-3) including GDP-mannose pyrophosphorylase.(8) UDP-glucose pyrophosphorylase is also derepressed in a haploid capR9 mucoid mutant. Heterozygous mucoid partial diploids with the capR9 allele on the episome and the wild-type (capR(+)) allele on the chromosome (F'capR9/capR(+)) are derepressed for UDP-glucose pyrophosphorylase and GDP-mannose pyrophosphorylase, while the reciprocal nonmucoid heterozygotes (F'capR(+)/capR9) are repressed for these enzymes. These results provide evidence that the episomal capR allele is dominant with respect to synthesis of these two enzymes.


Reversibility of the ATP:glutamine synthetase adenylyltransferase reaction. The reversibility of adenylylation of glutamine synthetase from E. coli by adenylyltransferase was demonstrated. Several positive effectors (Gln, 2-hydroxyethyl-S-cysteine, Trp and Met) stimulate the back reaction in the same manner as the forward reaction. The apparent Michaelis constant for PP(i) is 2.2 mM at pH 7.35. The pH optimum of the back reaction is 6.5-7 while the pH optimum of the forward reaction is 7.6. The apparent equilibrium constant in the presence of 10 mM Mg(2+) at pH 7.36 is 8.5 in favor of adenylylated glutamine synthetase and PP(i). The equilibrium constant is strongly dependent from pH and from Mg(2+) concentration. There is a difference of about 0.5 to 1 kcal/mole free energy between the adenylyl-O-tyrosine bond and the pyrophosphate bond of adenosine triphosphate (ATP). It follows from these considerations that the adenylyl-O-tyrosine bond is an "energy-rich phosphate bond."


Terminal cross-linking of DNA strands by an enzyme system from Escherichia coli infected with bacteriophage T4. An enzyme system, purified 560-fold from Escherichia coli infected with bacteriophage T4, catalyzes the formation of a phosphodiester bond between the original 5'-phosphoryl end-group of a DNA strand and a 3'-hydroxyl group of the complementary strand. The product, a terminally cross-linked, spontaneously renaturable DNA duplex, has been characterized by chromatographic analysis, by sedimentation analysis, and by enzymatic digestion. Essential components of the enzyme system, which requires both ATP and Mg(++), include the T4-induced DNA ligase and a component found in extracts of uninfected E. coli, which is probably an exonuclease.


The role of phosphatidylglycerol in the vectorial phosphorylation of sugar by isolated bacterial membrane preparations. Phospholipase D (cabbage) inhibits the vectorial phosphorylation of alpha-methylglucoside by isolated membrane preparations from Escherichia coli ML 308-225 without increasing the efflux of intramembranal alpha-methylglucoside-P. This effect is shown to be related to the ability of phospholipase D to hydrolyze membrane phosphatidylglycerol specifically. After treatment with phospholipase D, the membranes resynthesize phosphatidylglycerol with a return in their ability to take up alpha-methylglucoside. Since proline uptake by the same preparations is only slightly inhibited by phospholipase D, the data indicate that phosphatidylglycerol is required specifically for transport processes which are mediated by the P-enolpyruvate-P-transferase system.


Selection and characterization of an E. coli mutant defective in membrane lipid biosynthesis. A procedure is described for the selection of temperature-sensitive phospholipid mutants based upon radiation suicide of the wild-type organisms by tritiated L-glycerol-3-phosphate incorporated in the phospholipids. One of these mutants possesses an acyltransferase activity much more thermolabile than that of its parent. This mutant ceases growth and phospholipid biosynthesis immediately upon shift to a nonpermissive temperature although DNA, RNA, and protein continue to be synthesized. The phenotype of this mutant appears due to a single mutation by reversion analysis and by enzymatic analysis of temperature-resistant revertants.


Peptide chain termination. VII. The ribosomal and release factor requirements for peptide release. Release factors participate in release of fMet from fMet-tRNA . AUG . ribosome intermediates upon binding to ribosomes. This release requires R factor and occurs in the absence of terminator codon in reactions containing 20 per cent ethanol. Release occurs only when both 30S and 50S ribosomal subunits are present and when fMet-tRNA is located in the ribosomal P site. Release factor-dependent deacylation of fMet-tRNA is inhibited by sparsomycin, amicetin, lincocin, and chloramphenicol, antibiotics which have little effect on binding of R factor to ribosomes. The possible role of peptidyl transferase in the release reaction is discussed.


The uses and abuses of computers.

The uses and abuses of computers.


Relation between oral disease and acute bacterial endocarditis. Dental bacteriaemia.


Relation between oral disease and acute bacterial endocarditis. Is chemoprophylaxis necessary?


Admiral Lord Nelson's neurological illnesses.


Spencer Wells--Surgeon RN.

Spencer Wells--Surgeon RN.


The bacteriology of perihepatic and intrahepatic abscess.


Subphrenic abscess: the place of antibiotics.


Genetic repressors.

Genetic repressors.


Ox erythrocyte agglutinability. 2. Differential agglutinability.


Pepsin 'A' substance--further uses.

Pepsin 'A' substance--further uses.


A contribution to the morphology of aeromonas shigelloides.


The influence of the composition of the culture medium on the iron ammoniumcitrate reduction test with mycobacteria.


Effect of oculomotor and trigeminal nerve section on the ultrastructure of different myoneural junctions in the rat extraocular muscles.


The effect of visual deprivation on canine gastric secretion.


A design for the evaluation of antiviral drugs in human influenza.


History, evolution and use of the intramedullary nail.


The perineoabdominal operation. An improved operation for rectal cancer.


The fat embolism syndrome: with special reference to the importance of hypoxia in the syndrome.


Preparation of an infectious ribonucleic acid derived from mouse brains infected with Israel turkey meningo-encephalitis virus.


Hryntschak prostatectomy--520 cases.

Hryntschak prostatectomy--520 cases.


Self-performed operations for stone in the bladder.


Supply and preservation of cadaver kidneys.


The fate of "double-header" cadaveric renal allografts.


The influence of technical factors upon renal homograft function.


Platelet function: a review. I. Normal function.


Gastroenteritis of infants in two Canadian communities. Enteroviruses were isolated from 11 of 1391 rectal swabs collected from 1103 infants aged less than 2 years who were hospitalized in Toronto, Ontario, and New Westminster, British Columbia, between April 1966 and March 1969. Viruses were recovered from 23 of 1231 rectal swabs obtained from 1076 age-matched control patients without gastroenteritis. The dominance of coxsackievirus and echovirus strains in Toronto patients with and without gastroenteritis contrasted sharply to their extremely low incidence in New Westminster where the Sabin attenuated strains of poliovirus composed the majority of isolates from both categories of patient. Although enteropathogenic bacteria were identified in 36 cases of gastroenteritis and 11 control subjects, no patient excreted a bacterial pathogen and a virus simultaneously.


ECG data acquistion for computer analysis.


Hansen's disease.

Hansen's disease.


Pulmonary hematoma associated with thrombocytopenia.


Albert Tyler.

Albert Tyler.


Subacute necrotizing encephalomyelopathy (LEIGH).


Response of individual rats and sheep to one or more injections of hypothalamic extract as determined by radioimmuoassay of plasma LH.


Observations on forty-five cases of flat-foot with particular reference to etiology and treatment.


New operative approach in the treatment of chronic osteomyelitis of the tibial diaphysis. A preliminary report.


Pathomechanics and treatment of congenital vertical talus.


Effects of short- and long-term administration of pentazocine in man.


The effect of colicin G on the spheroplasts of Proteus mirabilis.


Continuous cultivation of microorganisms. A review.


The pathological substrate of temporal lobe epilepsy.


Purification and properties of mammalian liver cytidine triphosphate synthetase.


Patterns of ribonucleic acid synthesis in T5-infected Escherichia coli. II. Separation of high molecular weight ribonucleic acid species by disc electrophoresis on acrylamide gel columns.


Guanine and xanthine phosphoribosyltransfer activities of Lactobacillus casei and Escherichia coli. Their relationship to hypoxanthine and adenine phosphoribosyltransfer activities.


The development of proctology in the Massachusetts General Hospital.


Patterns of ribonucleic acid synthesis in T5-infected Escherichia coli. 3. Separation of low molecular weight ribonucleic acid species by disc electrophoresis on acrylamide gel columns.


Molecular weight determination of an acetyl-lipopolysaccharide by a surface micromanometer technique.


The development of the early larval stages of Trichuris muris in the albino laboratory mouse.


Toxoplasma in nucleus.

Toxoplasma in nucleus.


Preparing intestinal tracts of mice for studying adult Trichinella spiralis in situ.


Effect of ultrasonic instrumentation on bone.


Franz Hemerijckx, 1902-69.

Franz Hemerijckx, 1902-69.


Performance of the transplanted heart.

Performance of the transplanted heart.


Lysenko rides again.

Lysenko rides again.


Newer developments in the analysis of steroidsby gas-chromatography.


The intercistronic divide: translation of an intercistronic region in the histidine operon of Salmonella typhimurium.


Embryopathic effects of 7,12-dimethylbenz(a)anthracene and its hydroxymethyl derivatives in the Sprague-Dawley rat.


Baccalaureate and Masters Degree Programs in Nursing accredited by NLN, 1970-71. Department of Baccalaureate and Higher Degree Programs.


Bone marrow transplantation in irradiated monkeys: chromosome aberrations in donor cells.


Intergeneric transfer of a beta-lactamase gene between Ps. aeruginosa and E. coli.


Nursing restraints--past and present. 1.


Changing concepts in haemochromatosis.

Changing concepts in haemochromatosis.


Dying with dignity.

Dying with dignity.


Histocompatibility antigens on melanoblasts and hair follicle cells. Cell-localized homograft rejection in allophenic skin grafts.


The ultrastructure of the vomero-nasal organ in reptilia.


Ultrastructural changes in the median eminence of the rat following deafferentation of the basal hypothalamus.


Choice of anesthetic agents for intravenous regional anesthesia.


Low anterior resection in cancer of the rectum.


The surgical treatment of esophageal hiatus hernia.


Surgery for thyroid cancer.

Surgery for thyroid cancer.


Physiologic approach to frontalis lid suspension.


The surgical aphorisms of Moses Maimonides.


Modification of the hill suture in treatment of hiatal hernia.


Surgical management of aortic valvular diseases.


William Dameshek, 1900-1969.

William Dameshek, 1900-1969.


DFP labeling of platelets during recovery from thrombocytopenia.


Genetic and biological aspects of the HL-A system of human histocompatibility.


Chromatin clumping in mature leukocytes: a hitherto unrecognized abnormality.


The lymphocyte in immunological reactions in vitro: ultrastructural studies.


A critical review of some psychoanalytic literature on drug addiction.


On the presentation of the Proctor Medal award in ophthalmology to Dr. Hermann Burian.


The Korotkov's method. History of its discovery and clinical and experimental interpretation, and contemporary appraisal of its merits.


Remarks on acceptance of the Proctor Medal award.


A survey of 100 aphasic medicare patients in a speech pathology program.


Presbycusis.

Presbycusis.


Management of chronic brain syndrome secondary to cerebral arteriosclerosis, with special reference to papaverine hydrochloride.


Nonclostridial crepitant cellulitis.

Nonclostridial crepitant cellulitis.


Repair of the boutonniere deformity of the burned hand.


The current concept of interferon. A review.


Thrombosis of the abdominal aorta caused by blunt trauma.


Biogenesis of 50S ribosomes in E. coli: characterization of 43S precursors.


Methotrexate and its uses in dermatology.


Chronic glomerulonephritis associated with low serum complement activity (chronic hypocomplementemic glomerulonephritis).


Atypical mycobacteria. Their clinical, laboratory, and epidemiologic significance.


The olivopontocerebellar atrophies: a review.


Medulloblastoma. Current views regarding the tumor and its treatment.


Stimulation of gastric secretion of pepsin by secretin in man.


Diagnosis and treatment of mandibular tumors.


Rheumatology as a specialty in medicine. A personal appraisal.


Studies on the structure and innervation of taste buds. An experimental and clinical investigation.


Groups at risk in low birth weight infants and perinatal mortality.


Electron microscopic studies on flagellation in different strains of Yersinia enterocolitica.


Renal transplantation in the rabbit. Surgical technique.


Biosynthetic stability of the toxigenetic capacity of Clostridium tetani on repeated transfer in culture media.


Kidney transplantation in the rabbit. A new method.


Alterations in the regulation of circulation in experimental anaemia.


Hospital accreditation--past, present and future.


Single subcutaneous doses of histamine and pentagastrin in gastric fistula chickens.


Communicable diseases in twentieth-century India.


A trial of CI-564 (dapolar), a repository antimalarial for prophylaxis in Amapá, Brazil.


Malaria-antibody patterns as determined by the IFA test in U.S. servicemen after chemotherapy.


Experimental infection with Schistosoma haematobium in chimpanzees.


Antibiotic interaction with model membranes.


Clinical evaluation of a new drug for the treatment of ancylostomiasis.


Pharmacology and medicine.

Pharmacology and medicine.


Nonsteroid anti-inflammatory agents.

Nonsteroid anti-inflammatory agents.


Challenges in drug evaluation in man.

Challenges in drug evaluation in man.


Developmental pharmacology.

Developmental pharmacology.


L-asparaginase and L-asparagine metabolism.


Review of reviews.

Review of reviews.


Relationships between stereostructure and pharmacological activities.


Receptor mechanisms.

Receptor mechanisms.


Imidazolylacetolphosphate: L-glutamate aminotransferase-mechanism of action.


Tyrosine-inhibited 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase. Properties of the partially purified enzyme from Salmonella typhimurium.


Madness and poetry: a note on Collins, Cowper, and Smart.


Medical numismatics: a denarius commemorating Rome's first doctor, Arcagathus (219 B.C.).


Mozart: his tragic life and controversial death.


Ephedrine-adrenergic amine interaction on heart phosphorylase, adenyl cyclase and amine uptake.


The effect of hexamethonium on gastric acid and pepsin response to pentagastrin, histamine and AHR-602.


Studies on the digestibility of carbohydrates in pulses.


The autonomic nervous system and the peripheral circulation.


Effect of general anesthetics on peripheral blood flow.


Aspects of the autoregulation of cerebral blood flow.


Splanchnic blood flow during anesthesia.


Renal circulation in association with anesthesia and operation and during the postoperative stage.


Mechanisms of surfactant effects on drug absorption.


Cameo and profile: effective records of anterior esthetics and occlusion.


Neuromuscular stimulator and conditioner of the hard and soft tissues.


Gagging--a problem in prosthetic dentistry.


Maxillary removable partial denture designs by commercial dental laboratories.


Dr. Homer C. Vaughan receives citations.


The accuracy of correcting a defective rubber-base impression.


Experimental renal preservation.

Experimental renal preservation.


Etiology of pyelonephritis: significance of hemolytic Escherichia coli.


Urethral flap urethroplasty.

Urethral flap urethroplasty.


Chemotherapy of the lymphomas.

Chemotherapy of the lymphomas.


The physician as a medical book collector. Attempts at solving the acquisition problem.


Current status of myocardial mechanical-energetic relationships.


Alexander B. Gutman.

Alexander B. Gutman.


The scientific achievements of Dr. Alexander B. Gutman.


Structure of the ribosome.

Structure of the ribosome.


Punctuation in the genetic code in Escherichia coli.


The nervous system as a site of action for digitalis and antiarrhythmic drugs.


Lymphatic tissue germinal centers in immune reactions.


Synthesis of nucleic acids in giant chromosomes.


The excitation of photoreceptors.

The excitation of photoreceptors.


The mental state of the Norwegian traitor, Vidkun Quisling.


Evaluation of respiratory status in surgical patients.


Selected metabolic problems in surgical patients.


Preoperative preparation of the jaundiced patient. A review of current practice.


Guidelines in the use of cancer detection tests.


Pterygium with epithelial inclusion cyst and mycotic infection.


Eserine and pilocarpine: our 100-year-old allies.


Reminiscences of cardiac resuscitation.

Reminiscences of cardiac resuscitation.


Immunology of follicle-stimulating hormone and luteinizing hormone.


The endogenous control of estrus and ovulation in sheep, cattle, and swine.


Receptor-proteims for androgens and the mode of action of androgens on gene transcription in ventral prostate.


Small bowel control of pepsin secretion.


Single-blind randomised multicentre trial comparing heparin and streptokinase treatment in recent myocardial infarction.


Tympanic membrane grafts of full-thickness skin, fascia and cartilage with its perichondrium. An experimental and clinical investigation.


A simple micro-cinematographic system.

A simple micro-cinematographic system.


Studies on Yersinia enterocolitica growth on various solid media at 37 degrees C and 25 degrees C.


Immunodiffusion studies on Escherichia coli. 2. Characterization of antigens used for passive haemagglutination with an O 6 strain as model.


Quantitation of endotoxin-induced protein increase in the aqueous humor of the rabbit's eye.


Immunosuppressive action of L-asparaginase studied by means of the localized haemolysis in gel assay (L.H.G.A.).


Immunobiology of the mouse mutant "Nude". Preliminary investigations.


Molecular structure and biological function.


The endocrine pancreas in anencephalics. A histological, histochemical and biological study.


John Henry Gaddum,1900-1965.

John Henry Gaddum,1900-1965.


Adrenergic innervation of the female reproductive tract: anatomy, physiology and pharmacology.


Ancylostoma caninum: intestinal pigment granules.


The insensitivity of RNA synthesis to rifampicin in Neurospora mitochondria.


Role of human cell surface structures in interactions between man and microbes.


Anion permeability of the red blood cell.


Prevention of vesicovaginal fistulas.

Prevention of vesicovaginal fistulas.


The great eighteenth century obstetric atlases and their illustrator.


Ovulation induction.

Ovulation induction.


Measurement of cardiac output by means of the dye dilution technique using the dynamic method of curve calibration.


Problems of kidney transplantation from a living related donor in the light of an observed case.


General evaluation of results of surgical treatment of epilepsy.


Usefulness of the measurement of the muscle blood flow in the extremities using 133Xe.


Surgical research--1975.

Surgical research--1975.


Labyrinthine defects as shown by ataxia and caloric tests.


Evidence that the primary lesion in familial diabetes mellitus is an inherited defect of the beta-cell.


Possible role of insulin-stimulating hormones in disturbances of nutrient tolerance.


Human proinsulin: some considerations in the development of a specific immunoassay.


Offspring of animals with experimental diabetes.


Genetics of animals with spontaneous diabetes.


Some factors controlling differentiation and-or modulation of rat pancreatic islet cells.


Early stages of the diabetic state: definitions and concepts.


The genetics of diabetes mellitus.

The genetics of diabetes mellitus.


Complementary arguments in favor of the betacytotrophic action of the hypglycemic sulfonamides.


The effect of chlorpropamide therapy upon glucose-insulin relationships in adult diabetics.


Treatment of subclinical diabetes.

Treatment of subclinical diabetes.


A two-compartmental model for insulin secretion.


The mechanism of insulin secretion studied through the effects of electrolytes and inhibitors.


Insulin secretion in early diabetic animals: in vivo studies.


Dynamics of insulin secretion in early diabetes in humans.


Plasma substitutes past and present.

Plasma substitutes past and present.


Blood rheology - general review.

Blood rheology - general review.


Colour vision deficiency in on of two presumably monozygotic twins with secondary amenorrhoea.


Accurate edentulous impressions.

Accurate edentulous impressions.


Studies on Escherichia coli strains isolated from chronic respiratory disease of poultry in India.


Medical vagotomy.

Medical vagotomy.


Members of the Colorado Dental Association May, 1970.


American doctors in Paris, 1820-1861: a statistical profile.


The repetition of experiments and observations: its value in studying the history of medicine (and science).


On translating Galen.

On translating Galen.


Contagion and the constitution: quarantine agitation from 1859 to 1866.


Diphilus of Siphnos and Hellenistic medical dietetics.


James Hope and the acceptance of auscultation.


Acute diarrhoea in children. A study of 177 postmortem cases.


Bacteriology of diarrhoea in neonates with special reference to enteropathogenic coli.


Physiologic studies following canine lung homotransplantation: long-term survival of dogs.


An adventure in articulators.

An adventure in articulators.


Pulmonary surgery in immunosuppressed patients.


12345 procedures for the fabrication of an onlay.


Reinforcing the multi unit wax pattern for high fusing gold.


Design and construction of a double partial.


Procedure and technics in complete mouth restoration.


A new system of marking dentures for identification purposes.


A new sprue design for Ceramco castings.


Cosmetic labial prosthesis.

Cosmetic labial prosthesis.


The biology and technology of occlusion.


Isolation of double-stranded RNA from T4 phage infected cells.


Release factors mediating termination of complete proteins.


RNA at Cold Spring Harbor.

RNA at Cold Spring Harbor.


A factor promoting dissociation of Escherichia coli ribosomes.


VA dental fee schedule.

VA dental fee schedule.


The Philadelphia Neurosurgical Society.

The Philadelphia Neurosurgical Society.


Dr. Max Peet and his contributions to neurosurgery.


Memoir of S. Jervis Brinton 1892-1969.

Memoir of S. Jervis Brinton 1892-1969.


Memoir of John Westgate Hope 1914-1969.

Memoir of John Westgate Hope 1914-1969.


Memoir of David Warren Kramer 1890-1969.


Memoir of Eugene A. Meyer 1903-1969.

Memoir of Eugene A. Meyer 1903-1969.


Memoir of George Gordon Snyder, Jr. 1908-1969.


Annual report of the Mütter Museum and college collections.


A new method for the production of rabbit antirat lymphocyte serum.


Studies on the effects of heterologous antisera against subcellular lymphocyte fractions.


Renal transplantation in the inbred rat. X. A model of "weak histoincompatibility" by major locus matching.


Induction of specific immunological tolerance by parabiosis and antilymphocyte serum.


Scale (skin) allograft rejection in the primitive teleost, Osteoglossum bicirrhosum.


A study of combined treatment with chemical immunosuppressants and antilymphocytic serum to prolong skin allograft survival.


Detection of human lymphocyte isoantigens by rabbit homotransplantation sera.


Renal transplantation in the inbred rat. IX. Hematopoietic origin of an immunogenic stimulus of rejection.


Renal transplantation in the inbred rat. XI. Reduction of allograft immunogenicity by cytotoxic drug pretreatment of donors.


Transplantation of stored allogeneic bone marrow in dogs selected by histocompatibility typing.


Histological observations on long-term skin allografts in mice.


Acute rejection of skin and heart allografts in rats matched at the major rat histocompatibility locus.


Obituary.

Obituary.


Heart transplantation.

Heart transplantation.


Oral L-dopa treatment of parkinsonism.

Oral L-dopa treatment of parkinsonism.


Difficult problems encountered in the management of biliary obstruction due to stones and other benign conditions.


The stress ulcer syndrome.

The stress ulcer syndrome.


Leucineaminopeptidase reaction and skin transplantation.


Effect of bronchodilator drugs on the peak expiratory flow rate of asthmatic patients: oral orciprenaline and terbutaline (KWD 2019).


The Frederick A. Coller Surgical Society: past, present, and future.


Malignant lymphomas.

Malignant lymphomas.


Planning hospital library quarters.

Planning hospital library quarters.


Serotonin, and its effects on the pituitary-adrenal axis in depression.


A method of study.

A method of study.


Maintenance hemodialysis in perspective--1969.


Editorial comment: Dr. Marius N. Smith-Peterson.


From frog skin to sheep rumen: a survey of transport of salts and water across multicellular structures.


Professor MUDr. Frantisek Cerník is sixty.


Problems in heart transplantation.

Problems in heart transplantation.


Induction of tolerance to skin graft by previous immunization with an isolated antibody against tissue antigens of a skin graft donor. (Preliminary communication).


The faecal smear in the therapy of diarrhoeas.


Leptospirosis on Orchid Island, Taiwan.

Leptospirosis on Orchid Island, Taiwan.


Sensibility of indirect fluorescent method with living Trichinella spiralis larvae.


Reliability of the fluorescent antibody test for the serodiagnosis of swine trichinellosis in Trichinella free and endemic areas.


An accelerated method of peptic digestion of muscles at post-mortem diagnostics of pig trichinellosis.


Indirect fluorescent antibody test in diagnosis of trichinellosis.


A study of neurogenesis in the forebrain of opossum pouch young.


Proliferation of glomerular capillary endothelial cells under the influence of hypophyseal intermediate lobe materials.


A comparative study of the ultrastructure of the water-blood pathway in the secondary lamellae of teleost and elasmobranch fishes--benthic forms.


Ultrastructure and hormonal content of the proximal stump of the transected hypothalamo-hypophysial tract of the frog (Rana pipiens).


Fine structure of bovine surface endometrial cells in the estrous and luteal phases.


Cellular localization of 3H-oestradiol in the hypophysis. An autoradiographic study in male and female rats.


Cellular localization of 3H-oestradiol in the hypothalamus. An autoradiographic study in male and female rats.


A selected public health bibliography with annotations.


Roy Richard Grinker, Sr., at 70.

Roy Richard Grinker, Sr., at 70.


The psychiatric status schedule. A technique for evaluating psychopathology and impairment in role functioning.


The Missouri Standard System of Psychiatry (SSOP).


Diphenylhydantoin in children with severe temper tantrums.


Corneal injury caused by aerosol irritant projectors.


Postoperative tear cytology.

Postoperative tear cytology.


Rat retinal rods: freeze-fracture replication of outer segments.


Epilogue. Stress testing of the hypovolemic patient.


The pH 6 acetolactate-forming enzyme from Serratia marcescens. Purification and properties.


Relationship between sites 1,2 and acceptor, donor sites for the binding of aminoacyl tRNA to ribosomes.


Studies on the interaction of the inhibitor o-mercuriphenyl beta-D-galactoside chloride with beta-galactosidase from Escherichiacoli K 12.


Synthesis and characterisation of a copolymer consisting of alternating deoxyadenosine- and 2-thiodeoxythymidine nucleotides.


Increased priming for the secondary response in mice to sheep erythrocytes by bacterial endotoxins.


In memoriam Ernest Witebsky.

In memoriam Ernest Witebsky.


Partial tolerance to the dinitrophenyl group in neonatal and adult mice.


Symposium on bacterial spores: XVI. Sporeformers as insecticides.


Inoculation and survival of Azotobacter chroococcum on stored wheat seed.


The effect of carbon dioxide on spore germination in some clostridia.


A note on the effect of diluents on the determination of viable numbers of Azotobacteriaceae.


Clinical aspects of the inappropriate secretion of antidiuretic hormone. A review.


The occurrence and significance of pneumonia and other pulmonary complications in burned patients: comparison of conventional and topical treatments.


The use of mesh skin grafts in war wounds.


An iatrogenic radiopacity.

An iatrogenic radiopacity.


Histologic criteria for age estimation of the developing human dentition.


Surveillance of poliomyelitis in Japan from 1962 to 1968.


Sulfate-binding protein from Salmonella typhimurium: physical properties. This protein binds sulfate strongly and is implicated in sulfate transport in Salmonella typhimurium. It has a molecular weight of 32,000 and an axial ratio of 4:1. Crystals are elongate prisms up to 0.5 millimeter. X-ray diffraction photographs give discrete crystalline reflections to a spacing of at least 2 angstroms. The unit cell is orthorhombic P2(1)2(1)2(1), with four molecules per unit cell of 40.8 by 47.5 by 136 angstroms. This is consistent with a highly asymmetric molecule such as the prolate ellipsoid suggested by the other physical measurements. Addition of sulfate had minimum effects on the physical properties as measured by light absorption, optical rotary dispersion, circular dichroism, fluorescence and its depolarization, nuclear magnetic resonance, and sedimentation velocity.


Immunosuppressive effect of antilymphocyte serum on the canine lung allograft as a single immunosuppressive agent.


Immunosuppressive activity of L-asparaginase in mice.


A compendium of reported human bone marrow transplants.


Prolongation of skin allograft survival in lymphocyte-depleted mice.


Evaluation of twenty-four hour preserved primate kidneys.


Antigenic relationship between Shigella sonnei phase II and Enterobacter cloacae.


Phage and colicin typing of Shigella sonnei.


Induction and multiplication of lambda-phage. IV. The effect of panfuran.


Aerosol survival of Escherichia coli B disseminated from the dry state. Survival was determined for Escherichia coli B disseminated as an aerosol from the dry state. Survival in nitrogen, like that for wet dissemination, was better at low than at high relative humidity (RH). At high RH, survival was characterized by critical zones of instability in survival as a function of RH, instability occurring at 100, 95, 78, 70, and 60% RH. In air, survival was inferior to that in nitrogen at low RH, whereas the converse was found at high RH. The effect was attributed to oxygen. In general, results support the conclusion that to the first approximation survival is related to bacterial water content, the latter increasing with RH. However, a more detailed analysis of results indicates that survival might not be exactly related to bacterial water content. It is shown that death occurred because of rehydration and that the pretreatment of E. coli B affected its aerosol stability characteristics; i.e., wet and dry disseminated aerosols are not equivalent.


Laboratory identification of aeromonads from man and other animals. Forty-eight isolates of aeromonads from clinical specimens were studied. The laboratory procedures employed and the results obtained are reported in the hope that they may be of assistance to other workers in the field of diagnostic microbiology. Capability of identifying these organisms in the laboratory will contribute to a better understanding of the role of this group of organisms in human disease as well as in diseases in other animals.


Airborne stability of tailless bacterial viruses S-13 and MS-2. The effect of relative humidity (RH) on the airborne stability of two small bacterial viruses, S-13 and MS-2, was studied. Poorest recovery of S-13 was obtained at 50% RH. Humidification prior to aerosol sampling significantly increased the recovery of S-13 at RH deleterious to the airborne virus. A commercial preparation of MS-2 suspended in a buffered saline solution showed a rapid loss of viability at RH above 30%, whereas a laboratory preparation containing 1.3% tryptone showed high recoveries at all RH studied. Dilution of the commercial MS-2 into tryptone broth conferred stability on the airborne virus. Humidification prior to sampling significantly reduced the viable recovery from aerosols of commercial MS-2, whereas the laboratory preparation was unaffected.


Free endotoxin of Shigella sonnei phase I.


Effect of azathioprine on the development of allograft sensitivity in mice.


Nitrogen requirements and uricolytic activity of cutaneous bacteria. Uric acid, but not xanthine, was degraded by gram-positive catalase-producing cocci and diphtheroids which represented the two predominant human autochthonous skin bacteria. The proportions of uricolytic cocci and diphtheroids varied with the cutaneous site sampled. Uric acid and allantoin were not utilized by cocci or diphtheroids as sole sources of nitrogen. Uric acid appeared to act only as a secondary substrate for the gram-positive bacteria. Cutaneous cocci are known to be ureolytic but few diphtheroids had urease activity. Urea and ammonium nitrogen were not utilized as sole nitrogen sources by cocci, but some diphtheroids used these compounds for nitrogen. The majority of the cocci and diphtheroids were nutritionally fastidious and required amino-nitrogen for growth. In addition, some strains required vitamins and other unidentified metabolites found in yeast extract. These requirements were partially related to the cutaneous site from which the cocci or diphtheroids were isolated. Certain gram-negative bacilli degraded uric acid and utilized urate or its degradation products as nitrogen sources.


A preserved antigen for the hydatid fluorescent-antibody and other tests utilizing scolices.


Inhibition of mitochondrial and bacterial protein synthesis by chloramphenicol.


David James McCulloch.

David James McCulloch.


The California Medical-Economic Survey; Paul A. Dodd versus the California Medical Association.


The physician versus the Negro: medical and anthropological concepts of race in the late nineteenth century.


Henry Rouse Viets, 1890-1969.

Henry Rouse Viets, 1890-1969.


Tissue oxidation and theoretical physiology: Bernard, Ludwig, and Pflüger.


Spina bifida: the significance of the level and extent of the defect to the morphogenesis.


Alexis St. Martin and Dr. Bunting.

Alexis St. Martin and Dr. Bunting.


Fetus-fetus interaction--a model aetiology for anencephalus.


Obituary. A.V. Neale, M.D., F.R.C.P., D.P.H.


Microscopic pattern of healing of the cryogenic thalamic lesion.


Anorexia nervosa. A survey of the literature and review of 30 cases.


Successful 20-hour storage of the canine liver by continuous hypothermic perfusion.


Serology in leprosy.

Serology in leprosy.


Electron microscopy of leprosy lesions.

Electron microscopy of leprosy lesions.


The treatment of leprosy with a new long-acting sulfonamide.


The sensitivity and resistance of different E. coli serotypes, associated with infantile diarrhoea, to various antibiotics and chemotherapeutic agents.


Fibrosarcomas in infants and children.

Fibrosarcomas in infants and children.


Clinical problems encountered in renal homotransplantation in children.


Cadaveric allotransplant immunosuppression by lymph lymphocyte depletion.


Immediate life support by a single transplanted lung in puppies.


John Peter Mettauer (1787-1875).

John Peter Mettauer (1787-1875).


Melancholy and suicide.

Melancholy and suicide.


Progress in lymphology II.

Progress in lymphology II.


Blastogenic responses of lymphocytes from patients with untreated and treated lymphomas.


Primary cutaneous cryptococcosis. Seroimmunologic and fluorescent antibody studies.


Disease of small bowel. Past, present, and future.


Balthasar (Isaak) Orobio de Castro, M.D. (1620-1687). Marrano physician and theologic disputant.


Acutely burned patient. Initial care and closure of burn wound.


Burn wound management with biologic dressings.


Socioeconomic progress in surgery.

Socioeconomic progress in surgery.


Body composition in intrauterine growth retardation.


Physiology of aging leukocytes. I. Phagocytosis and transformation.


Immunofluorescence of mycoplasma colonies grown on coverslips.


Effect of a hypothalamic extract on serum prolactin levels during the estrous cycle and lactation.


Development of tumour in transplanted lungs of newborn and adult mice.


Throat flora of a closed colony of beagles.


A morphogenetic matrix for differentiation of cartilage in tissue culture.


An oriented plastic slicing guide for facilitating stereotaxic interpretations in brain sections.


An air drying method for the preparation of dictyotene chromosomes from ovaries of Chinese hamsters.


Investigation of gastrin activity in pancreatic islet tissue.


Preventing the rejection of transplanted organs.


On the resuscitation of the apparently dead.


An experimental study on the sympathetic neuron chains using the fluorescence method for biogenic monoamines.


Experimental transfer of allergic information in laboratory animals.


Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics.


Cholesterol requirement of mycoplasmas.

Cholesterol requirement of mycoplasmas. Cholesterol requirement for growth of mycoplasmas was tested in a serum-free medium supplemented with albumin, l-arginine, palmitic acid, and various concentrations of cholesterol dissolved in Tween 80. In cases in which Tween 80 was shown to inhibit growth, the test medium was supplemented with cholesterol dissolved in ethanol. Of the 31 species examined, all but Mycoplasma laidlawii, M. granularum, and Mycoplasma species strain S-743 exhibited a growth response to cholesterol. No requirement for cholesterol could be shown with the stable L-phase variants of Streptobacillus moniliformis and Proteus species. The results provide experimental support for the view that the large majority of the established Mycoplasma species require cholesterol for growth.


Sequence of genes replicated in Salmonella typhimurium as examined by transduction techniques. 5-Bromouracil (BU) was pulsed into the genome of synchronously growing cells of an F(-) strain of Salmonella typhimurium of LT2. BU-labeled genes were transduced with P22 phage to a series of recipient auxotrophs. When BU was incorporated early in the replication cycle, the transducing markers that had hybrid densities were those that lie between 9 and 12 o'clock on the genetic map. When BU was incorporated during the terminal period of the synchronous cycle, the transducing particles had hybrid densities for genes that lie from 1 to 8 o'clock clockwise. When phages were prepared on cells in which the middle period was BU-labeled, transducing particles with hybrid densities appeared for genes that lie in two separate regions: between 7 and 9 o'clock and between 12 and 2 o'clock. Analysis of the map sequences of the transduced BU genes, the relative frequency of transduction for each marker, and the time sequence of replication led to a hypothesis that the origin of replication is near the isoleucine-valine gene on the chromosome map. As for direction of replication, several models were considered, including the possibility that replication may proceed in both directions in the same chromosome. It was also found that the aroB, cysG, and strA genes are cotransduced and strA and aroC are also cotransduced. The relative order of the four genes was found to be aroB, cysG, strA, aroC, but the orientation in the circular map was not determined.


Genetic stability of various resistance factors in Escherichia coli and Salmonella typhimurium. Genetic stability of R factors was studied in Salmonella typhimurium LT-2 and Escherichia coli K-12. It was found that fi(+) R [or R(f)] factors were unstable in LT-2, losing their drug-resistance markers at high frequencies, and were stable in K-12; fi(-) R [or R(i)] factors were stable in both hosts. Both fi(+) and fi(-) R factors were genetically stable also in recombination-deficient mutants of K-12. An fi(+) R factor, which was unstable in S. typhimurium LT-2 wild type, was relatively stable in a recombination-deficient mutant of LT-2. In the spontaneous loss of the drug-resistance markers of fi(+) R factors in LT-2, the markers for sulfanilamide, streptomycin, and chloramphenicol resistance were lost together at high frequencies and the tetracycline marker was retained stably. The remaining drug-resistance markers of the spontaneous segregants of LT-2 were transmissible to K-12 by mixed cultivation, indicating that they were still in the form of R factors.


Dark-recovery processes in Escherichia coli irradiated with ultraviolet light. 3. Effect of rec mutations on recovery of excision-deficient mutants of Escherichia coli K-12. Mutants of Escherichia coli K-12 unable to excise pyrimidine dimers from their deoxyribonucleic acid (DNA) because of a uvr mutation show a higher survival when plated on a minimal salts medium after exposure to ultraviolet radiation than when plated on a complex medium such as nutrient agar containing yeast extract. This response has been called minimal medium recovery (MMR). Recovery of uvr mutants can take place in liquid as well as on solid medium, but not in buffer or under conditions of amino acid starvation that do not permit cell growth and normal DNA replication. MMR can thus be distinguished from the recovery of recombination-deficient (rec(-)uvr(+)) derivatives of K-12 which can occur under conditions where growth is not possible. Because MMR is characteristic of excision-defective mutants, it evidently reflects a type of repair independent of excision. We have obtained genetic evidence that MMR is determined by the rec genes, which also control recombination in K-12. Cells carrying a uvr mutation together with recA13, recA56, recB21, or recC22 failed to show MMR and were more sensitive to ultraviolet radiation than either their rec(+)uvr(-) or rec(-)uvr(+) parents. The rec(+)uvr(-) derivatives obtained from recA uvr(-) strains by transduction or by reversion regained the capacity for MMR. Our results indicate that inactivation of any one of the three genes, recA, recB, or recC, prevents cells from showing MMR.


Physiological basis of transient repression of catabolic enzymes in Escherichia coli. Transient repression of catabolic enzymes occurs in cells that encounter a new carbon compound in their growth medium, but only when the cells contain the enzyme catalyzing the transfer of phosphate from phosphoenolpyruvate to a small heat-stable protein (HPr), as well as a permease capable of transporting the new compound across the cell membrane. The newly added compound need not be metabolized. The degree and duration of the transient repression have no obvious relation to the intracellular level of the exogenously added compound. It is suggested that the actual passage of the compound through the cell membrane is responsible for the repression.


Loss of colicinogeny in Escherichia coli strains infected by certain resistance factors. The original observation that in wild-type colicinogenic Escherichia coli strains the introduction of some R factors abolish their colicin production was studied in certain col(+) strains bearing well-defined col factors. Two resistance (R) factors were used and introduced by conjugation in these strains, namely the 222 factor of Watanabe and a Salmonella typhimurium ST factor (coding for resistance to streptomycin and tetracycline only). The introduction of above mentioned R factors abolished the colicin production of col(+) strains most probably by elimination of col factors. All col factors, however, were not equally susceptible to elimination by the R factors tested, since colicin production in ML strains was abolished by infection by the 222 factor but not by the R factor of S. typhimurium ST, which is able to eliminate other col factors.


Hemin-deficient mutants of Salmonella typhimurium. Nine hemin-deficient mutants of Salmonella typhimurium LT2 were isolated as neomycin-resistant colonies. Five of these mutants could be stimulated by Delta-aminolevulinic acid (Delta-ALA), thus representing hemA mutants. Since S. typhimurium LT2 is not able to incorporate hemin, the identification of the mutants not stimulated by Delta-ALA was made on the basis of the simultaneous loss of catalase activity and cytochromes. The hemA gene was mapped by conjugation in the trp region, probably in the order purB-pyrD-hemA-trp; the episome FT(71)trp does not carry the hemA gene. Transductional intercrosses by phage P22 indicate that hemA 11, 12, 13, and 37 are at very closely linked sites, whereas hemA14 is at a more distant site in the same or an adjacent gene. No joint transduction was detected between hemA and trp or pyrF. The loci affected in the other hemin-deficient mutants were linked in conjugation to the pro(+) marker (frequency of linkage, 88 to 97%), but cotransduction of the two markers could not be obtained. The episome F lac hem purE, which originates from Escherichia coli K-12, could complement these hemin-deficient mutants of S. typhimurium LT2. As a result, the sequence of the markers on the chromosome of S. typhimurium LT2 is probably pro heme purE, analogous to the sequence found in E. coli K-12. Thus, the chromosome of S. typhimurium also possesses two hem regions, with a location similar to that described in E. coli K-12.


Mutants of Salmonella typhimurium lacking phosphoenolpyruvate carboxykinase and alpha-ketoglutarate dehydrogenase activities. Two auxotrophic mutants (SM16 and SM51) of Salmonella typhimurium, which for aerobic growth, with hexoses as carbon source, required lysine and methionine (SM51 required also nicotinic acid), were isolated and characterized. The requirement for the amino acids disappeared in anaerobiosis. Neither lipoate nor 4-hydroxybenzoate was effective in supporting aerobic growth of the mutants. The lysine and methionine requirement for aerobic growth was due to the absence in the mutants of the enzymatic activities of the alpha-ketoglutarate dehydrogenase complex. The mutants could not use succinate as carbon source even after enrichment of the growth medium with acid-hydrolyzed casein and yeast extract. No phosphoenolpyruvate carboxykinase activity was found in the mutants, a phenomenon which explained their inability to use succinate. By interrupted conjugation and by transduction experiments, the positions of the three affected loci, pck, suc, and Nic, were located at approximately 17 to 19 min of the S. typhimurium chromosome; they were found to be closely linked. From different criteria, it appears as if the genetic lesions present in both mutants are due to deletion of a small chromosome fragment.


Intracytoplasmic membrane structures in Vibrio marinus. An electron microscope study of Vibrio marinus strains MP-1, an obligate psychrophile, and PS-207, a moderate psychrophile, revealed numerous intracellular membranous structures. The structures were found to occur more frequently in V. marinus strain MP-1 than in strain PS-207. The frequency of occurrence and complexity of structure were related to age of the culture. In early logarithmic phase, cells revealed invaginations of the plasma membrane. More complex membrane forms, found in late logarithmic and stationary phase, were either myelin-like sheaths, for which the term "myelemma" is proposed, or membranes randomly arranged throughout the cells. The complex membrane forms were not observed to be directly connected with the plasma membrane. However, they were often found in approximation to the plasma membrane or associated with vacuoles and circular membrane profiles. Individual membranes were of a tripartite structure and of dimensions similar to the cell wall and plasma membrane.


Bacteriophage receptor development and synthesis of O-specific side chains after addition of D-galactose to the uridine diphosphate-galactose-4-epimeraseless mutant Salmonella typhimurium LT2-M1. The formation of complete cell wall core lipopolysaccharide (LPS) and O-antigenic side chains after addition of d-galactose to the uridine diphosphate-galactose-4-epimeraseless mutant, Salmonella typhimurium LT2-M1, has been studied by (i) determination of adsorption rates of smooth and rough specific bacteriophages, (ii) passive hemagglutination inhibition, and (iii) qualitative and quantitative determination of the polysaccharide composition and structure. A rapid synthesis of the complete core LPS and O side chains occurred in bacteria in the log phase and the early stationary phase. Phage C21, which attaches to unsubstituted Rc structures, was adsorbed by the bacteria for only 10 min after the addition of d-galactose. Unsubstituted Rc structures, however, could still be detected after 160 min by immunological and chemical assays. Attachment of the P22 phage, which requires O-specific side chains with more than one repeating unit for adsorption, was demonstrated 10 min after the addition of d-galactose. Attachment of the Felix O-1 phage, which requires a complete core, was observed between 20 and 80 min after the addition of d-galactose. The rough specific phages 6SR and Br2 did not adsorb to the bacteria at any time after the addition of d-galactose. By passive hemagglutination inhibition, the presence of O-specific structures could be demonstrated after 10 min. No antigenic activity of the Ra and Rb structures was observed in the LPS preparations isolated at any time after the addition of d-galactose. Methylation analysis of LPS preparations isolated at 10 and 160 min after the addition of d-galactose showed that the O-specific side chains contained an average of 11 and 15 repeating units, respectively. In the 10-min sample, every 25th "Rc structure" carried a side chain, compared to every 3rd residue in the 160-min sample.


Ultrastructure of Escherichia coli depleted of an amino acid. Particles accumulating during amino acid starvation of Escherichia coli C600 are described and illustrated.


Properties of a deoxyribonucleic acid ligase mutant of Escherichia coli: x-ray sensitivity. A deoxyribonucleic acid ligase-deficient mutant is X-ray sensitive relative to the parent strain, suggesting that deoxyribonucleic acid ligase functions in repair of X-ray-induced, single-strand scissions.


Changes in resistance to radiation and heat during sporulation and germination of Clostridium botulinum 33A. During sporulation, Clostridium botulinum 33A developed resistance to ultraviolet and gamma rays about 2 hr prior to its development of heat resistance. During germination, loss of resistance to heat, ultraviolet radiation, and gamma radiation occurred essentially simultaneously.


Selection of araB and araC mutants of Escherichia coli B-r by resistance to ribitol. The growth of strain araC(c)67, which produces the enzymes of the ara operon constitutively, is inhibited by the addition of ribitol. Isolation of strains resistant to ribitol yields mutants of either the araB or araC genes. A model to account for the inhibition by ribitol is discussed.


Abortive transduction of resistance factor by bacteriophage P22 in Salmonella typhimurium. When R factor 222 is transduced by bacteriophage P22 in Salmonella typhimurium, most recipient bacteria which adsorb transducing particles do not give rise to transductant clones (i.e., transduction is abortive); however the transduced drug-resistance genes can be rescued by recombination with the resistance-transfer factor or R factor carried by the recipient.


In vitro induction of lysosomal enzymes by phagocytosis. The in vitro induction of lysosomal enzymes by phagocytosis was demonstrated in cultivated mouse peritoneal macrophages. The contribution of each of several steps in the endocytic process to enzyme induction was examined. The enzymatic response after the uptake of equal numbers of erythrocytes (RBC) and nondigestible particles were compared. Phagocytosis of RBC produced a marked increase in the levels of acid phosphatase, beta-glucuronidase, and cathepsin D. Puromycin (1 microg/ml) inhibited the enzyme response. In contrast, phagocytosis of polyvinyl toluene, polystyrene, and insoluble starch particles produced no increase in macrophage lysosomal enzymes, although fusion of phagosomes with preexisting lysosomes occurred normally. The endocytic stimulus to synthesis of inducible lysosomal enzymes, therefore, occurred at or beyond the stage of digestion. Purified protein (bovine gamma globulin) aggregates and homopolymer coacervates of poly-l-glutamic acid: poly-l-lysine were effective inducers of lysosomal acid phosphatase, beta-glucuronidase, and cathepsin D, whereas homopolymers of the same D-amino acids were ineffective as inducers. Both the quantity of phagocytized substrate and its rate of enzymatic hydrolysis appear to control the level and persistance of lysosomal hydrolases.


Transfer of skin homograft immunity with a plasma factor.


Alloantibodies induced by weaker histocompatibility antigens in rats.


An in vitro primary immune response to 2,4,6-trinitrophenyl substituted erythrocytes: response against carrier and hapten.


Comet plaques: evidence for storage of low efficiency hemolysins by indirect plaque-forming cells.


Phylogeny and oncogeny.

Phylogeny and oncogeny.


Melanotic tumors in Drosophila melanogaster.


Attempts to sensitize mice for PCA using pepsin digested mouse antibody fragments.


Essential relationship between the lymphoid system, immunity, and malignancy.


A critical review of neoplasia and tumor-like lesions in mollusks.


The natural history of recurrent bacteriuria in schoolgirls.


Acute diarrhea--a "toxin" disease?

Acute diarrhea--a "toxin" disease?


Biologic concomitants of alcoholism. 1.

Biologic concomitants of alcoholism. 1.


The lysosomes and their possible role in periodontal disease.


Qualitative analysis of dental prosthetic materials.


Bite analysis and its significance in modern odontology. A historical retrospect with special attention to the role played by Scandinavia in the development and dissemination of this doctrine.


On the construction of temporary fixed saddle-bridges; some case-reports.


Glucose production and utilization in the newborn puppy.


Anorganic bone. II. A clinical-roentgenologic study.


Efcts of optically active isomers and racemate of mepivacaine (Carbocaine) in dental anaesthesia.


The vacuum effect in impression-taking.

The vacuum effect in impression-taking.


Octopressin as a vasoconstrictor in anaesthetics used for oral surgery.


Review of physiological measurement techniques for applicability to space flight conditions. NASA CR-1277.


Characteristics of innocent and stenotic cervical bruits.


Hydralazine and methyldopa in thiazide-treated hypertensive patients.


Of the United States Government, history taking, and the physical examination.


Developmental responses to high altitude hypoxia.


Therapeutic activity of 4-allyloxy-3-chlorophenylacetic acid.


A review of retrograft membranes Vancouver General Hospital, 1960-1968.


On- and off-response ratio in the visual pathway of the cat.


The effect of hypothermia on frog's cellular and vascular response to heterotopic corneal xenografts.


The saddle bridge--the bridge with a difference. I.


The contribution of the host and the graft cells in the healing of corneal transplants--an autoradiographic study.


Cytological studies of plasma albumin in the rat liver.


Special heart-transplant cart holds supplies for surgery.


Mixing and observation errors in indicator-dilution studies.


An analysis of mathematical models of circulatory indicator-dilution curves.


A new method for measurement of cardiac output with nitrous oxide.


Out of our medical past: Dr. Benjamin Rush, Dr. William Cullen, and a noble prophecy.


Massive rectal prolapse. A suggested method of surgical repair.


Canine early immunohistological responses to cardiac transplants.


Intraoral lichen planus simplex: an ultrastructure study.


Polycythemia. Differential diagnosis and treatment.


Dentistry in times of change.

Dentistry in times of change.


Prosthetic treatment for a patient with a hypersensitive palate.


Orthodontic and surgical correction of malocclusion.


Experimental and environmental factors in cancer. A review of research with animals.


Irritation fibroma. Report of a case.

Irritation fibroma. Report of a case.


The disappearance of Xe133 and I125 from skeletal muscle of the anesthetized dog during sympathetic cholinergic vasodilatation.


Salmonellosis in the United States--a five-year review.


Charles Henry Tweed, Jr. (1895-1970).

Charles Henry Tweed, Jr. (1895-1970).


Automated microbiological assay. I. Experiences in assaying ampicillin and carbenicillin.


Evaluation of allograft function following cardiac transplantation.


Sterilization of aortic valve grafts for transplantation.


Immediate, early, and prolonged lung function after autotransplantation. A serial study.


Evaluation of the transplated lung with angiography and xenon 133 scanning.


Cause of abnormal bleeding after transplantation of pig liver stored by a perfusion technique.


Methenamine salts as topical antibacterial agent. I. Experimental studies for burn and crush wound.


Changes of serum potassium during renal homotransplantation.


A technique for end-to-side vascular anastomosis.


Ultrafine structure of te cell elements in hard chancres of the rabbit and their interrelationship with Treponema pallidum. Investigating the interrelationship between Treponema pallidum and the host cells, the authors have studied under the electron microscope ultrathin sections of cellular elements of rabbit chancres and the condition of the treponemes. A description is given of the structure of the basic cellular elements found in the chancres, particularly the plasma cells since it is in them that the main immunological processes take place.The morphology of the treponemes varies in the course of the pathological process as well as with the type of cell harbouring them. Enveloped in multi-layered membranes, the treponemes may lie within plasma cells and may retain all their characteristic features, indicating that they remain viable and that their envelopes can protect them from the action of antibodies and drugs. In long-standing chancres cyst-like formations with multi-layered membranes have been found.


Vibrio parahaemolyticus and diarrhoea associated with non-cholera vibrios.


The effect of small single doses of cloroquine on Plasmodium faiparum infections in north-eastern Tanzania.


Evidence for muramic acid in soil.

Evidence for muramic acid in soil.


Bacteria in estuarine (Bras d'Or Lake) sediment.


A comparative study of cardiac outputs in dogs using indicator-dilution curves and an electromagnetic flowmeter.


Ultrastructural changes in keratinizing epithelium following trypsinization, epidermal detachment and apposition to mesenchymes.


The proliferation of myofibrils during muscle fibre growth.


Continuing education program to meet future needs.


Effect of research involvement in public health issues on attitudes of students.


The localization of Australia antigen by immunofluorescence. We have studied the localization of Australia antigen, a particulate substance associated with hepatitis, by means of the fluorescent antibody technique. Preparations were made from 61 liver biopsy specimens taken from patients with infectious hepatitis, serum hepatitis, and a variety of other diseases. When tested with fluorescein-conjugated rabbit anti-Au(1) antisera all 26 patients who had Au(1) in their serum had specific fluorescence in their liver cells. The fluorescence appeared in three forms: as discrete particles within the nucleus, diffuse fluorescence of the entire nucleus, and fluorescence of the nuclear rim. Occasionally there were also fluorescent particles in the cytoplasm. Other specimens were tested with the fluorescent antibody including a variety of human tissues, buffy coat smears, peripheral lymphocyte cultures, and cells obtained from bile and duodenal drainage. Among these specimens, fluorescence was found in the cytoplasm of a few cells in the bone marrow of two patients with hepatitis and Au(1) in their serum, and in the liver, spleen, mesentery, and testis of one patient with leukemia, chronic hepatitis, and Au(1) in his serum. We have shown that the presence of fluorescent particles in the liver cells is strongly associated with the presence of Au(1) in the serum and the diagnosis of viral hepatitis. We believe that this study adds support to the hypothesis that Australia antigen is an antigenic determinant of a virus capable of causing hepatitis.


Obituary: Sir Brian Herbert Swift.

Obituary: Sir Brian Herbert Swift.


Non-immunological hydrops fetalis.

Non-immunological hydrops fetalis.


Induction and repression of L-arabinose isomerase in bacteriophage-infected Salmonella typhimurium. The induction of l-arabinose isomerase in Salmonella typhimurium (LT2) is repressed on infection with clear plaque forming mutants (C(1) and C(2)) of the temperate phage P22 (C(+)). However, after infection with C(+) leading to lysogeny, there is a temporary repression. During this period, messenger ribonucleic acid (RNA) for l-arabinose isomerase accumulates. DNA-RNA hybridization data suggest that there is transcription of host DNA during the period of repression. Interference at the level of translation might be responsible for the cessation of induced enzyme synthesis.


The problem or oral ulcerations in general practice with special reference to herpetic herpetiform lesions.


Suppression of adsorption properties of a z mutant of bacteriophage T4 by r mutations. The products of bacteriophage T4 r genes influence the organization of the phage-adsorption apparatus in a noncatalytic way.


Inhibition of translation of preformed lac messenger ribonucleic acid by T4 bacteriophage. Cells infected with bacteriophage T4 are unable to translate beta-galactosidase messenger ribonucleic acid which exists in the cell before infection, unless translation is underway at the time of infection.


Intracellular inactivation of bacteriophage T4 early deoxyribonucleic acid. As previously shown, a small amount of polynucleotide material is added to parental T4 deoxyribonucleic acid (DNA) molecules within the first 5 min of infection. I have asked whether this process is essential for phage replication. Two approaches-one involving decay of (32)P incorporated into this "early DNA" and the other involving photoinactivation of bromodeoxyuridine-containing early DNA-indicate that it is.


Female gender identity and absence of fetal gonadal hormones: Turner's syndrome.


The Royal Salop Infirmary "clicking splint".


Treatment of pilonidal sinus.

Treatment of pilonidal sinus.


Increased extracellular fluid after open intracardiac operation.


Surgical consequences of alcoholism.

Surgical consequences of alcoholism.


The course of chronic hemophilus bronchitis treated with massive doses of penicillin and penicillin combined with streptomycin.


Comparison of antigenic fractions obtained by Seibert and Affronti method from protoplasm and culture filtrates of Mycobacterium bovis (BCG).


Treatment of ventriculitis with gentamicin and cloxacillin in infants born with spina bifida.


Diphenoxylate hydrochloride therapy in the diarrhoea of malnourished infants.


Pyelonephritis lenta. Consideration of childhood urinary infection as the forerunner of renal insufficiency in later life.


Vertebral abnormalities in first degree relatives of cases of spina bifida and of anencephaly.


The subunits of methionyl-transfer-ribonucleic acid synthetase.


Some aspects of phenylalanine incorporation in deuterium oxide (D20) substitution for water (H20) in polyuridylic acid-directed ribosomal protein biosynthesis.


Evidence for the role of terminal regions of tropocollagen in fibrillogenesis: specific enzymic degradation studies.


Inhibition by streptomycin of the biosynthesis of cyclic depsipeptides in Serratia marcescens.


Effect of metabolic inhibitors on glucagon release from isolated guinea-pig islets of Langerhans.