The iodotyrosine content of normal human serum.


A comparative trial of three proprietary antibiotic preparations used in the treatment of acute infections.


A comparative trial of chlorhexidine and hexachloraphane deodorant sprays.


Phenformin as an aid to weight reduction.


Adhesive properties and slime formation of vibrios and their relationship to haemagglutination.


Trace elements and cardiovascular diseases.


Increased lipid in thymic macrophages parasitized by Mycobacterium lepraemurium.


Phase-contrast observation on influence of ruby laser-radiation on living cells.


An open trial of indomethacin therapy in exacerbated phases of lepromatous leprosy.


Bacteremia study using a water irrigation device.


The laboratory of hygiene. A history of its development.


Events leading up to and the establishment of the Grosse Ile Quarantine Station.


Canada--and the World Health Organization.


The history of the health facilities design division.


Infantile cortical hyperostosis (Caffey's syndrome). A report of four cases from general practice.


Erythromycin estolate in general practice. A comparative trial of two dosage forms.


Imipramine in enuresis.

Imipramine in enuresis.


The plague at Eyam.

The plague at Eyam.


Addison's disease, fever, hepatosplenomegaly, and pleuropericardial effusions.


Diagnostic laboratory medicine--leptospirosis--methods in the laboratory diagnosis.


Macroscopic processing of the human brain with a stereotactic lesion.


Radiograph made by Roentgen.

Radiograph made by Roentgen.


The eosinophilic pneumonias.

The eosinophilic pneumonias.


Multicentric reticulohistiocytosis. A review of 33 patients.


Treatment of the infant and young child with myelomeningocele.


Walking training of the young child with myelomeningocele.


Doctor, patient, and society.

Doctor, patient, and society.


A comparison between medical and surgical treatment of glaucoma simplex--results of a prospective study.


The principles of penetrating keratoplasty.


Squint incisions: a controlled series.

Squint incisions: a controlled series.


Bruce Alexander Brown.

Bruce Alexander Brown.


John Bruce Hamilton.

John Bruce Hamilton.


The Ophthalmological Society of Australia. Officers of the Society to October, 1968.


Muscle blood flow in normal and hypertensive subjects. Influence of age, exercise, and body position.


Survival following first diagnosis of coronary heart disease.


Mechanisms of Graves' disease and endocrine exophthalmos.


Skin lesions and arthritis.

Skin lesions and arthritis.


Louis Chargin, MD. (1879-1969).

Louis Chargin, MD. (1879-1969).


Gastrin and gastric secretion.

Gastrin and gastric secretion.


Samuel Beresford Child, M. D.

Samuel Beresford Child, M. D.


Haemodialysis and tertiary hyperparathyrodism: renal homotransplantation and tubular dysfunction.


Cystic fibrosis of the pancreas in adolescence and adulthood.


Characterization of avian encephalomyelitis virus (an avian enterovirus).


Silver impregnation of degenerating axons and their terminals on Epon-Araldite sections.


Conduction velocity of rat optic nerve fibers.


A new method for the selective impregnation of degenerating axon terminals.


Connections of cerebral structures functioning in neurohypophysial hormone release.


Two Nineteenth-Century textbooks of medicine.


Significance of fixation in the cytochemical demonstration of ornithine carbamoyltransferase activity--with special reference to aldehyde perfusion.


The Kissam family: its importance in New York medicine.


The inaugural Murugesar Sinnetamby Oration.


Nucleic acid synthesis in embryos and its bearing on cell differentiation.


The catabolism of long chain fatty acids in mammalian tissues.


The medical history of Jonathan Swift.

The medical history of Jonathan Swift.


Clinical evaluation of a topical nasal decongestant--oxymetazoline.


A review of inherited osteopetrosis in the mouse. Man and other mammals also considered.


The effect of radiation on small competing populations of Drosophilamelanogaster. I. The accumulation of genetic damage.


Orthotopic cardiac prosthesis: preliminary experiments in animals with biventricular artificial heart.


Ronald A. Fisher.

Ronald A. Fisher.


The effect of radiation on small competing populations of Drosophila melanogaster. II. The changing frequencies of autosomal recessive lethals.


Complementation of nonchemotactic mutants of Escherichia coli.


Chromosomal rearrangements in Escherichia coli strains carrying the cryptic lambda prophage.


Fat embolism. Report of a case and discussion of current concepts of pathogenesis and treatment.


Some notes on Jacobus Dalechampius and his translation of Theophrastus (manuscript: BN. Lat. 11,857).


Additional bibliography of thermoluminescent dosimetry.


The flying death: classic papers and commentary on curare.


Intra-uterine growth and development.

Intra-uterine growth and development.


Experiments and observations on the different modes in which death is produced by certain vegetable poisons by Sir Benjamin Collins Brodie.


Quantification of fat, muscle and bone in man.


Wanderings in South America by Charles Waterson. II.


Further experiments and observations on the action of poisons on the animal systems by Sir Benjamin Collins Brodie.


Three cases of tetanus, in which "woorara" was used by T. Spencer Wells.


Curari, the flying death. The primitive and mysterious poison used by natives of the amazon jungles in their blowguns may prove of value to civilized medical science by Richard C. Gill.


Curare alkaloids. I. Tubocurarine by Harold King.


The ultrastructure of a reptilian myoneural junction by J. David Robertson.


Curare alkaloids from Chondodendron tomentosum by O. Wintersteiner and J. D. Dutcher.


Preventing traumatic complications in convulsive shock therapy by curare by A. E. Bennett.


d-Tubocurarine chloride by T. Cecil Gray.


Death following neostigmine by J. Clutton-Brock.


The peripheral action of ether estimated on isolated nerve-muscle preparation. 3. Antagonistic and synergistic actions of ether and neostigmine by Ole Secher.


Death after neostigmine injection by Marie Hill.


Neuromuscular blocking properties of antibiotics as a cause of post-operative apnoea by E. R. J. Emery.


The response of the newborn infant to muscle relaxants.


Disseminated tuberculosis with associated haematological disorders. A report of six cases.


Control of isoleucine, valine, and leucine biosynthesis. VI. Effect of 5',5',5'-trifluoroleucine on repression in Salmonella typhimurium. The leucine analogue 5',5',5',-trifluoroleucine (fluoroleucine) replaced leucine for repression of the isoleucine-valine biosynthetic enzymes in Salmonella typhimurium. In contrast, the analogue had no effect on derepression of the leucine biosynthetic enzymes in leucine auxotrophs grown on limiting amounts of leucine. The effect of fluoroleucine on repression appeared to be specific for leucine since derepression of the isoleucine-valine enzymes due to an isoleucine or valine limitation was not affected by the analogue. The prevention of derepression by fluoroleucine was probably due to repression and not to the formation of false proteins, since the analogue had no effect on the derepression of a number of enzymes unrelated to the isoleucine-valine pathway. Fluoroleucine was able to attach to leucine transfer ribonucleic acid (tRNA) as evidenced by the ability of the analogue to protect about 70% of leucine tRNA from oxidation by periodate. We propose that the differential effects of fluoroleucine on repression are due to differences in the ability of the analogue to bind to the various species of leucine tRNA.


Oncoupling of protein and ribonucleic acid synthesis by 5',5',5'-trifluoroleucine in Salmonella typhimurium. The addition of 5',5',5'-trifluoroleucine (fluoroleucine) to leucine auxotrophs of Salmonella typhimurium permitted protein but not ribonucleic acid (RNA) synthesis to continue after leucine depletion. The uncoupling of the formation of these macromolecules by fluoroleucine was apparent if RNA and protein synthesis was measured either by the uptake of radioactive precursors or by direct chemical determinations. The analogue did not appear to be an inhibitor of RNA formation, since it was as effective as leucine in permitting RNA synthesis in a leucine auxotroph upon the addition of small amounts of chloramphenicol. In contrast to these data, fluoroleucine allowed continued protein and RNA formation in a leucine auxotroph of Escherichia coli strain W. In addition, contrary to the results obtained with S. typhimurium, the analogue replaced leucine for repression of the leucine bio-synthetic enzymes as well as the isoleucine-valine enzymes. We propose that these ambivalent effects of fluoroleucine on repression and RNA and protein synthesis in the two strains are due to differences in the ability of the analogue to attach to the various species of leucine transfer RNA.


Antigenic structure of Treponema pallidum, Nichols strain. II. Extraction of a polysaccharide antigen with "strain-specific" serological activity. An ultracentrifugally homogeneous heat-stable polysaccharide preparation free from serologically reactive rabbit testicular tissue antigen, including cardiolipin, was extracted from the Nichols strain of Treponema pallidum, and found to react by complement-fixation with homologous rabbit sera but not with human syphilitic sera. In addition, the reactive "strain-specific" component was found to be distinct from a second reactive component within the preparation related to an antigen of T. reiteri.


Interaction of Bdellovibrio bacteriovorus and host bacteria. II. Intracellular growth and development of Bdellovibrio bacteriovorus in liquid cultures. The intracellular life cycle of Bdellovibrio bacteriovorus 109 growing on Escherichia coli in a dilute nutrient medium exhibits a period of constant infective titer while the parasite grows and elongates inside the host cell. This period is terminated after 2 to 4 hr, and the number of the plaque-forming units in the culture rises rapidly to as much as six times the initial titer. The growth pattern of Bdellovibrio is similar with actively growing or resting host cells, or with host cells killed by ultraviolet irradiation or by heating at 70 C. The yield of B. bacteriovorus strain 109 in two-membered cultures with E. coli B depends on the host concentration and may reach 7.5 x 10(10) cells per ml. Penicillin, which has no effect on the attachment and penetration of Bdellovibrio, inhibits its multiplication.


Streptomycin action: greater inhibition of Escherichia coli ribosome function with exogenous than with endogenous messenger ribonucleic acid. Inhibition of protein synthesis by streptomycin was tested in extracts from a strain of Escherichia coli sensitive to streptomycin. Three kinds of messenger ribonucleic acid (RNA) were employed: endogenous cellular RNA, extracted cellular RNA, and phage R17 RNA. Protein synthesis directed by extracted cellular RNA was inhibited three- to fourfold more than protein synthesis directed by endogenous RNA. With R17 RNA as messenger, nearly total inhibition of protein synthesis at initiation was again observed. The greater inhibition of function of extracted RNA, which must initiate new polypeptide chains in vitro, is in accord with the observation that in whole cells streptomycin blocks ribosomes at an early stage in protein synthesis. When streptomycin was added at successively later times during protein synthesis, the subsequent inhibition was progressively less. This was observed with either extracted cellular RNA or phage R17 RNA. A model is presented that can explain the less drastic inhibition by streptomycin of messenger RNA that is already functioning on ribosomes.


Escherichia coli K-12 mutants resistant to nalidixic acid: genetic mapping and dominance studies. Escherichia coli K-12 strains tested so far (approximately 20) can be separated into three groups on the basis of their abilities to form colonies on nutrient agar supplemented with nalidixic acid (NAL): (i) Nal(s) or wild type (no growth at 1 to 2 mug/ml); (ii) NalA(r) (growth at 40 mug/ml or higher); and (iii) NalB(r) (growth at 4 mug/ml, but no growth at 10 mug/ml). The NalA(r) group has a spectrum of sensitivity ranging from 60 to over 100 mug/ml. All Hfr strains of the NalA(r) and NalB(r) groups transfer NAL resistance to recipient cells at genetic loci which are at 42.5 +/- 0.5 and 51 +/- 1 min, respectively, on the Taylor-Trotter map. Some members of the NalA(r) group also have the genetic locus for NalB(r). The nalA(s) allele is completely dominant to nalA(r) in a partial diploid configuration. In haploids, nalA(r)-nalB(r) is phenotypically NalA(r); nalA(r)-nalB(s) is NalA(r); and nalA(s)-nalB(r) is NalB(r). The map location of nalA and the easy differentiation between NalA(r) and NalA(s) allow this marker to be used as a counterselector in bacterial conjugation experiments.


Chromosomal location of ribosomal protein cistrons determined by intergeneric bacterial mating. Intergeneric mating between Escherichia coli and Salmonella typhosa was used to locate at least three 30S ribosomal proteins near the streptomycin locus in the region of 54 to 66 min of the E. coli map. This procedure utilizes differences in the electrophoretic patterns of 30S ribosomal protein of the parents. The results show that cistrons for 30S proteins of E. coli can replace those of S. typhosa in the Salmonella genome. Moreover, in a diploid hybrid with a Salmonella endogenote and an E. coli exogenote, both sets of cistrons are expressed.


Expression of the arginine regulon of Escherichia coli W: evidence for a second regulatory gene. Effect of the M (modifier) gene of Escherichia coli W on the expression of wild-type structural genes of four arginine biosynthetic enzymes was studied by examining enzyme activity in cell-free extracts of cultures grown in minimal medium and medium containing arginine. The mutant M gene was originally identified as causing arginine-induced synthesis of acetylornithine delta-transaminase in a strain deficient for the enzyme. The strains used in this study received the mutant M gene by recombination. Noncoordinate repression has been demonstrated for two more enzymes of the arginine regulon of E. coli W and the M(-) gene increases the degree of noncoordinate repression for the regulon. Mutation of the M gene results in altered regulation of acetylornithine delta-transaminase, ornithine transcarbamylase, and acetylornithinase. In addition, a decreased growth rate is observed. It is proposed that the M gene is a regulatory gene. A model is presented to explain the data which involves changes in operator-repressor affinity for the structural genes and possibly for the gene controlling arginyl transfer ribonucleic acid synthetase.


Transduction of merodiploidy: induced duplication of recipient genes. Escherichia coli PB160, which carries a tandem duplication with the gene order metB(+)argH(-)su(159) (+)thi(+): metB(+)argH(+)su(159) (-)thi(+), was used to study the mechanism of P1 transduction of genes in the duplicated region. Transduction of the su(159) (+) allele contained within the duplicated segment yields two kinds of su(159) (+) recombinants: 91% are haploid su(159) (+) and 9% are su(159) (+)/su(159) (-) merodiploids. The duplication in these merodiploid transductants includes the metB locus; however, both copies of the metB locus usually are derived from the recipient. Thus, the requirements for transduction of the "condition of merodiploidy" appear to be the cotransduction of the repeat point (the region where the duplication begins to repeat itself) and, of course, the selected marker (in this case su(159) (+)). A mechanism whereby two recipient chromosomes interact with the transduced "repeat point" region to regenerate the tandem duplication is implicated. It appears that a duplication much larger than the quantity of genetic material carried by a P1 phage can be produced in a transductant.


Temperature-sensitive repression of the tryptophan operon in Escherichia coli. Mutants of Escherichia coli exhibiting temperature-sensitive repression of the tryptophan operon have been isolated among the revertants of a tryptophan auxotroph, trpS5, that produces an altered tryptophanyl transfer ribonucleic acid (tRNA) synthetase. Unlike the parental strain, these mutants grew in the absence of tryptophan at high but not at low temperature. When grown at 43.5 C with excess tryptophan (repression conditions), they produced 10 times more anthranilate synthetase than when grown at 36 C or lower temperatures. Similar, though less striking, temperature-sensitivity was observed with respect to the formation of tryptophan synthetase. Transduction mapping by phage P1 revealed that these mutants carry a mutation cotransducible with thr at 60 to 80%, in addition to trpS5, and that the former mutation is primarily responsible for the temperature-sensitive repression. These results suggest that the present mutants represent a novel type of mutation of the classical regulatory gene trpR, which probably determines the structure of a protein involved in repression of the tryptophan operon. In agreement with this conclusion, tRNA of several trpR mutants was found to be normal with respect to its tryptophan acceptability. It was also shown that the trpS5 allele, whether present in trpR or trpR(+) strains, produced appreciably higher amounts of anthranilate synthetase than the corresponding trpS(+) strains under repression conditions. This was particularly true at higher temperatures. These results provide further evidence for our previous conclusion that tryptophanyl-tRNA synthetase is somehow involved in repression of this operon.


Morphology and round body fermation in Vibrio marinus. The morphology of Vibrio marinus MP-1 was studied by phase and electron microscopy. The ultrastructure of the vibrio form of V. marinus was found to be typically gram-negative with a trilaminar plasma membrane and cell wall. The coccoid or round bodies noted in otherwise pure cultures of V. marinus were frequently found in early and late stationary phase of growth. The round bodies in ultrathin section were found to contain at least one, and often three or four, cell units. Three types of round bodies were observed in ultrathin section, each differing in size and behavior: "spherules," "spheres" or the "round body," and "giant cells" or "macrospheres." The round bodies appeared to be associated with, or to result from, the constrictive cell division of V. marinus.


Amino acid antagonist death in Escherichia coli. Six analogues of amino acids killed corresponding auxotrophs of Escherichia coli. With all but one analogue, protein synthesis was required for lethality.


New method for the detection of a lethal factor in vibrios. When vibriocinogenic vibrios were mixed with an indicator strain, "lacunas" (plaquelike clearings) were observed, thus providing a new method for detection of vibriocins.


Thermal reversal of ultraviolet-irradiation damage in Salmonella typhimurium. Effects of ultraviolet irradiation on lysogenic and nonlysogenic Salmonella typhimurium grown at 25 C are partially reversed by shifting cultures to 43 C immediately after irradiation.


Genetic transfer of the Vi antigen from Salmonella typhosa to Escherichia coli. The Vi antigen was expressed in a strain of Escherichia coli after transfer of the viaB locus from a Salmonella typhosa Hfr donor.


Occult endotoxin in bacterial protoplasm. Protoplasm separated from disrupted cells of gram-negative bacteria was extracted with hot phenol-water or was precipitated with ethyl alcohol after digestion with Pronase. These methods recovered about 10 times more endotoxin than was detectable in the untreated protoplasm. Inactivation of endotoxin by protoplasm also occurred in vitro when the endotoxin was first dissociated into subunits before reaction with protoplasm. Despite this increased yield from another source, the major proportion of endotoxin was still found in the cell walls.


New class of conditional colicin-tolerant mutants. A new class of temperature-dependent tol mutants of Escherichia coli expresses tolerance to colicins only after growth at higher temperatures. Colicin sensitivity or tolerance, acquired by growth at 30 or 41 C, respectively, is not lost upon incubation at the other temperature in the presence of chloramphenicol. The kinetics of conversion from sensitivity to tolerance and vice versa have been analyzed. In one instance, the tol VIII temperature-dependent phenotype was due to the modifying role of a str-r mutation on the suppression of a tol VIII amber mutant by the suppressor mutation suII. The bearing of the present findings on the role of the tol genes is discussed.


The delta cell of the human hypophysis in childhood.


Stimulation of LH release in men and women by LH-releasing hormone purified from porcine hypothalami.


Diazoxide-induced renin release in man: dissociation from plasma and extracellular fluid volume changes.


Can LATS be detected by immunofluorescence?


Arginine induced growth hormone release after clomiphene treatment.


The role of the Voltaic pile in the Galvani-Volta controversy concerning animal vs. metallic electricity.


A brief history of the wheelchair.

A brief history of the wheelchair.


James Currie to Sir Joseph Banks: an unpublished letter.


Birth order research 1963-1967: bibliography and index.


The use of topical 5-fluorouracil in the treatment of skin tumours--preliminary report.


Histological control of specimen selection for electron microscopy.


The effect of refractive index of the mounting medium on the apparent diameter of latex particles and glass fibres.


Reticulum cell sarcoma with primary manifestation in the testicle: 3 case reports.


Presentation of Dr. George Herbert Hitchings for the Passano Award.


Clinical and in vitro evaluation of cephalexin. A new orally administered cephalosporin antibiotic.


A quarter century of chemotherapy.

A quarter century of chemotherapy.


Separation and determination of bile pigments.


Cytosine derived heteroadduct formation in ultraviolet-irradiated DNA.


Purification and properties of initiation factor f2.


Messenger RNA stability and polarity in the Lac operon of Escherichia coli.


Malnutrition and the pancreas.

Malnutrition and the pancreas.


Malabsorption due to neomycin.

Malabsorption due to neomycin.


Raw soybean meal and pancreatic secretion.


Physical training and cardiovascular status.


Proinsulin, insulin, and vascular permeability.


Effects of aflatoxin ON THE LIVER.

Effects of aflatoxin ON THE LIVER.


Transferable intestinal factor which depresses body weight.


A role of copper in elastin formation.

A role of copper in elastin formation.


Physical therapy and medicare.

Physical therapy and medicare.


Walter Hjalmer Baer. 1902-1968.

Walter Hjalmer Baer. 1902-1968.


Pierre Le Damany on congenital dysplasia of the hip.


Tumour of bone, testis and breast: reticulum cell sarcoma.


Parasitic infections current in Britain.


Leukoplakia and oral cancer.

Leukoplakia and oral cancer.


The side-effects of carbamazepine.

The side-effects of carbamazepine.


Detection of hog cholera virus in normal pigs salvaged from infected herds and hyperimmune pigs from biological companies.


Factors predisposing to ischaemic heart disease.


The effect of 5 Escherichia coli serotypes on gnotobiotic swine.


Standard procedures for the isolation and typing of mycobacteria.


Standard procedures for histopathologic diagnosis of tuberculosis.


Can expectation of life in Western populations be increased by changes in diet and manner of life? II.


How can doctors and veterinarians make a joint contribution to the development of organ transplantation?


The ultrastructure of the pecten oculi in the chick. II. Observations on the bridge and its relation to the vitreous body.


An electron microscope study of the perfusion-fixed spleen. 1. The splenic circulation and the RES concept.


The effects of metopirone and aldactone on the pars distalis of the pituitary, the interrenal tissue and the interstitial tissue of the testis in the common frog, Rana temporaria.


Blastic reaction of the regional lymph node as a method for quantitative evaluation of tissue incompatibility.


The immunofluorescence method in the study of immunologic phenomena accompanying spontaneous regression of Crocker sarcoma.


Kinin levels in experimental endotoxic shock.


Transplant psychosis.

Transplant psychosis.


Another look at the results of cardiac transplantation.


An infrared study of the conformation of RNA and protein in the ribosome.


Transplantation analysis of F2 generation of hybrids between two mouse strains differing at known histocompatibility loci.


Genetic aspects of the graft-versus-host reaction of mice.


Serologically detected antigens in two sublines of the WAG rats.


Observations of the effect of horse anti-pig leucocyte serum in suppressing the rejection of skin allografts in pigs.


The historical development of insanity as a defense in criminal actions. I.


Alexander O. Gettler 1883-1968.

Alexander O. Gettler 1883-1968.


Carcinoma of the stomach.

Carcinoma of the stomach.


Role of respiratory gases in control of fetal and neonatal hemodynamics.


Official roster of affiliated societies.


Treatment of acute leukemia.

Treatment of acute leukemia.


Preliminary report on the production of experimental mastitis in the mouse.


An outbreak of salmonellosis involving veterinary hospital patients.


Temporomandibular joint dysfunction. Case report.


Effects of hypothalmic implants of GH on anterior pituitary weight and GH concentration.


Carcinogenesis and sanity.

Carcinogenesis and sanity.


Seafood toxins.

Seafood toxins.


More clues in the cadmium and zinc puzzle.


Characteristics of the enzymatic breakdown of DNA in Escherichia coli in response to ionizing radiation.


In vivo observations of mammalian peripheral nerve fibres.


An investigation in the cross-linking of proteins by various fixatives.


Direction of psychosexual interest and figure drawing choice.


A projective technique for assessing family relationships.


Experimental pyelonephritis: enhancement of infection after delivery of Escherichia coli into the arterial supply of the kidney.


The renal lesion in chronic pyelonephritis: immunofluorescent and ultrastructural studies.


Studies on the epidemiology of Escherichia coli, 1960-1968.


A phase-contrast device with positive and negative image contrast.


An electron-microscopic study of cholinesterase distribution in the rat adrenal medulla.


Chronic bacteriuria due to Escherichia coli. I. Assessment of the value of combined short- and long-term treatment with cycloserine, nitrofurantoin, and sulphadimidine.


Studies on insect fibrous proteins: the structural protein of the ootheca in the praying mantis, Sphodromatis centralis Rehn.


A method of processing third-stage larvae of the nematode Trichostrongylus colubriformis for electron microscopy.


Role of the galactose transport system in the retention of intracellular galactose in Escherichia coli.


Effect of temperature on the oligonucleotide stimulation of the RNA polymerase reaction.


RNA synthesis in Escherichia coli after irradiation with ultraviolet light.


A transcription-initiating mutation within a structural gene of the tryptophan operon.


Protein synthesis in Escherichia coli after irradiation with ultraviolet light.


Re-initiation of polypeptide synthesis and polarity in the lac operon of Escherichia coli.


Mapping of polypeptide reinitiation sites within the beta-galactosidase structural gene.


Autolytic enzymes and cell division of Escherichia coli.


A complementation analysis of the restriction and modification of DNA in Escherichia coli.


The rate of DNA unwinding.

The rate of DNA unwinding.


Translation control of viral RNA in Escherichia coli.


Initiation of DNA replication in Escherichia coli 15T-: chronological dissection of three physiological processes required for initiation.


Polyribosome depletion and blockage of the ribosome cycle by streptomycin in Escherichia coli.


Role of polynucleotide ligase and DNA polymerase in the repair of DNA damage.


Accurate alginate impressions.

Accurate alginate impressions.


Artificial undercuts for teeth which have unfavorable shapes for clasping.


The use of the semiprecision rest in removable partial dentures.


Iatrogenic blushing of dentin following full crown preparation.


Constructing mandibular implants during surgery.


The criteria for friendship.

The criteria for friendship.


The structural basis of the elastic properties in the flight muscle of the bee.


Studies relating to the mode of action of methotrexate. 3. Inhibition of thymidylate synthetase in tissue culture cells and in cell-free systems.


Mechanism of secretion from the adrenal medulla. V. Retention of storage vesicle membranes following release of adrenaline.


Protein synthesis: uncoupling of polymerization from template control.


Insulin secretion in sheep with autotransplants of the pancreas.


Ribosomal subunits produced by cold sensitive initiation of protein synthesis.


Initiation factor requirements for the in vitro synthesis of T4 lysozyme.


Circadian rhythmicity in photoperiodically induced gonadotrophin release and gonadal growth in the quail.


Visual receptive fields of cells in a cortical area remote from the striate cortex in the cat.


Transferable antibiotic resistance.

Transferable antibiotic resistance.


Transplantation. 2. Kidney transplantation. The donor.


Remember nursing back when?

Remember nursing back when?


An inspector calls ...

An inspector calls ...


Leadership, group activity and sociometric choice in service sororities and fraternities.


Identification with the aggressor through figure drawings.


Gas gangrene following compound fracture of femur.


Venous pressure and other thoughts.

Venous pressure and other thoughts.


Four illustrious neuroluetics (Heinrich Heine, Jules de Goncourt, Alphonse Daudet, Guy de Maupassant).


The history of the reflecting microscope.


Congenital malformations of the lower back in childhood.


International directory of genetic services.


Intraluminal lead of the gastric action potentials in human subjects: use of a new suction-needle electrode.


Successful repair of a traumatic aneurysm of the abdominal aorta.


Effect of vasopressin (Pitressin) on gastric mucosal blood flow measured by clearance of krypton.


Modification of established rejection of canine kidney and liver homografts with antilymphocyte gamma-G globulin.


Failure of amantadine hydrochloride to suppress canine renal homograft rejection.


A comparative study of small-bowel anastomoses by angiography and microangiography.


Experimental wound sepsis from transient Escherichia coli bacteremia.


Changes in intestinal flora in dogs with nonstrangulating intestinal obstruction.


Hemodynamics of pulmonary valvular stenosis in chronic dogs.


New technique for the repair of arteriovenous fistulas in dogs.


Prolongation of functional survival of second-set canine renal homografts using antihymocyte serum: preliminary report.


Desipramine in treatment of Parkinson's disease. A placebo-controlled study.


Neuronal plasticity and memory.

Neuronal plasticity and memory.


Some correlates of early-detected emotional dysfunction in the schools.


The basis for segmental sequential irradiation in Hodgkin's disease: extended vs. local fields in the radiocurability of the SJL-J mouse Hodgkin's-like reticulum cell sarcoma.


The American Journal of Roentgenology Radium Therapy and Nuclear Medicine.


Metabolism of herbicides.

Metabolism of herbicides.


IV. Occurrence and distribution of pesticide residues. Pesticide residues in the atmosphere.


The occurrence and significance of pesticide residues in wild animals.


Pesticide residues in soils, water, and crops.


Body burden of pesticides in man.

Body burden of pesticides in man.


Economic implications of pesticide use.

Economic implications of pesticide use.


V. Biochemical effects. Phosphorylation and carbamylation of cholinesterase.


Pesticides and human toxicity.

Pesticides and human toxicity.


Studies on delayed neurotoxicity produced by some organophosphorus compounds.


Ecological effects of pesticides.

Ecological effects of pesticides.


Current status of pesticide residue methodology.


I. General aspects of pesticide use. The chemistry of pesticides.


Anthropoid apes in experimental medicine: a review.


Surgical approaches to the study of fetal immunology in primate animals.


3. Metabolism of pesticides. The nonmetabolic decomposition of pesticides.


A preliminary report on single-unit responses in the thalamus and cortex of the chimpanzee under sedation.


Relationships among coagulase, enterotoxin, and heat-stable deoxyribonuclease production by Staphylococcus aureus. The relationship between heat-stable deoxyribonuclease and coagulase production was investigated in the interest of developing more rapid diagnostic and quantitative procedures for distinguishing toxigenic and pathogenic staphylococci from closely related saprophytic organisms.


Determination of antibiotic susceptibility of Rickettsia by the plaque assay technique. Plaque formation by various rickettsiae was completely inhibited by commercial antibiotic discs impregnated with tetracycline, chloramphenicol, nitrofurantoin, and erythromycin; partial inhibition was observed around discs containing nalidixic acid and sulfisoxazole, but no inhibition was seen around discs containing cephalothin, ampicillin, oxacillin, kanamycin, polymyxin B, streptomycin, or penicillin.


Modified microbiological assay for rapid estimation of antibiotic concentrations in human sera. Antibiotic concentrations in human sera were estimated in 5 to 6 hr by a modified microbiological assay. By using Staphylococcus aureus and Streptococcus pyogenes as the assay organisms, the seeded assay plates were preincubated for 2 to 6 hr and then were stored at 4 C until used for assay. Paper discs saturated with the specimen were placed on the preincubated assay plates with reference discs saturated with known concentrations of antibiotic. After 5 to 6 hr of incubation, zones of antibacterial activity were measured and compared with a standard curve for estimation of antibiotic concentration. Results from this rapid assay method compared favorably with those from the commonly used 24-hr assay.


Resistance of spores of Clostridium botulinum 33A to combinations of ultraviolet and gamma rays. Spores of Clostridium botulinum 33A exhibit a sigmoidal survival curve if subjected to gamma radiation. The present investigation was concerned with two questions: (i) what is the form of an ultraviolet (UV)-survival curve and (ii) what is the combined effect of UV- and gamma radiation? The UV-survival curve was found to be of sigmoidal type with a "shoulder" width of 675 ergs/mm(2) and a D(10) (exp) of 2,950 ergs/mm(2). To test the combination effect, spores were subjected to UV doses of 225, 450, 675, and 900 ergs/mm(2) followed by a series of increasing doses of gamma rays from 200 to 2,000 krad in 200-krad steps. The gamma ray-survival curves showed that increasing UV pretreatment caused a gradual loss of the "Prodiginine" yielding straight line exponential survival curves after preirradiation with UV doses of 675 ergs/mm(2) and above. Simultaneously the D(10) value for gamma-ray irradiation was reduced, e.g. UV preirradiation with 900 ergs/mm(2) reduced the D(10) by 40%. This observation emphasizes the potential practical advantage of combining UV and gamma rays for sterilization of heat-sensitive commodities.


Rapid determination by light scattering of growth parameters of Mycoplasma laidlawii in liquid media. An impediment to progress in the study of the course of growth, the effects of medium components, antibiotics, etc., of Mycoplasma has been the cumbersome methods of growth measurement currently in use. Heretofore, it required the plating of numerous samples during growth, at least in triplicate, after appropriate dilution, followed by a delay of 2 to 3 days before the colonies developed so that counts could be made. We applied the technique of light scattering to measure the growth of Mycoplasma laidlawii in liquid culture continuously in a manner analogous to the use of absorbancy for bacteria. Scattered light measurements precisely paralleled data obtained by the tedious method of plate counts and were available immediately during the development of the culture. The lower limit of sensitivity with the system described is 10(5)Mycoplasma per ml. The presence of serum in the medium lowers sensitivity somewhat. However, concentrations of serum up to 10% are easily tolerated. Higher serum content may require calibration curves. Thus the technique may be used with many pathogens, etc., that require serum to develop. One can easily and rapidly measure differences in growth rates as well as final cell yields during the course of growth, rather than 3 days later, after colonies have developed.


Quantitative urine culture by surface drop method. A simple drop method for quantitative urine culture was developed and tested in comparison with standard methods for bacterial urinary counts. In a group of 452 urines all yielding Escherichia coli, 74 showed counts of more than 100,000 colonies, and 16 showed counts between 10,000 and 100,000 colonies per ml. Of these 90 urines, 3 of the 16 in the doubtful group were false negative with the drop method. Another 7 urines in the total number of 452 showed discrepancies, but, because all would have been repeated, the second urine sample would have corrected the primary result. The ease and cleanliness of the method render it a suitable technique for screening normal and patient populations. The method was applied on a population sample of 1,330 persons from whom unwashed mid-stream urine was collected and yielded figures comparable with results published in the literature. The method discriminates between steps of 10-fold difference, whereas more accurate count methods show a standard error of +/-25% and are reliable in a double dilution series.


In vitro studies of a new semisynthetic penicillin, 6-(d-alpha-sulfoaminophenylacetamido)-penicillanic acid. The activity of 6-(D-alpha-sulfoaminophenylacetamido)-penicillanic acid was determined against 357 clinical isolates of gram-negative bacilli by use of the tube-dilution technique. The majority of the isolates of Pseudomonas species were inhibited by 200 mug/ml or less of this antibiotic. Most of the isolates of Escherichia coli had a minimal inhibitory concentration of 50 mug/ml or less. Seventy-three per cent of the isolates of P. mirabilis, 40% of the isolates of P. morganii, and 45% of the isolates of Enterobacter species were inhibited by 12.5 mug/ml or less, whereas most of the isolates of Klebsiella species and Serratia species were resistant. The activity of this semisynthetic penicillin was affected by the size of the inoculum. The drug was bactericidal against all isolates of E. coli and Proteus species that were sensitive to it, but it was bactericidal against only 32% of the sensitive isolates of Pseudomonas species.


Identification of human strains of Actinomyces viscosus. Catalase-positive actinomycetes which closely resemble the "hamster organism" described by Howell have been isolated from dental calculus and other human sources. These cultures could not be distinguished from the hamster strains on the basis of morphology, oxygen requirements, biochemical reactions, or cell wall composition. These human isolates have been classified with the hamster strains as Actinomyces viscosus. The strains from hamster and human sources fell into two serotypes. Serotype 1 contains the hamster strains plus one strain of unknown origin, whereas serotype 2 contains all of the human strains.


Neonatal drug depression and respiratory distress managed by positive pressure ventilation and exchange transfusion.


Distribution of malarial antibody in maternal and cord sera.


Wilhelm Meyer and the adenoids.

Wilhelm Meyer and the adenoids.


Education in radiology.

Education in radiology.


Nodular sclerotic lymphosarcoma: a possible new clinico-pathological entity.


Tumour-specific antibodies in human malignant melanoma and their relationship to the extent of the disease. Biopsy specimens and sera were obtained from 103 melanoma patients. Autoantibodies were demonstrated by (1) complement-dependent cytotoxicity of autologous melanoma cells in short-term culture; (2) complement-dependent inhibition of ribonucleic acid synthesis; (3) immunofluorescent staining of the cytoplasm of killed melanoma cells and of the surface membrane of viable melanoma cells. Over one-third of the sera studied had antibodies to autologous melanoma cells. Although for technical reasons all three tests could not be performed with the cells from every melanoma, whenever multiple testing was possible there was complete concordance. The autoantibodies were virtually confined to patients in whom the disease was not widely disseminated, and over 80% of such patients had positive sera. In a limited number of patients who have been followed autoantibodies disappeared as the disease progressed to become widely disseminated. Two patients with generalized disease developed autoantibodies following inoculation by their own irradiated tumour cells.TWO TYPES OF AUTOANTIBODIES WERE RECOGNIZED: one, active against antigen(s) in the cell surface membrane, was specific for each tumour-that is, only the autologous serum reacted-and was concerned in the cytotoxic activity; the other reacted with cytoplasmic antigens which appeared to be present in most or all melanoma cells.


Major blunt chest trauma.

Major blunt chest trauma.


On the nature of psycho-historical evidence: in search of Gandhi.


Research in psychopharmacology.

Research in psychopharmacology.


Erikson's search for Gandhi.

Erikson's search for Gandhi.


History and psychoanalysis.

History and psychoanalysis.


The converging paths of behavior therapy and psychotherapy.


Notes on the scope of the psychohistorical approach.


Assessment of a bacterial adherence colony (BAC) method for enumeration of antibody-forming cells to E. coli somatic antigen.


The effect of dose of antigen on protein and DNA synthesis in antibody-forming cells.


Enhancing antibody. II. Specificity and heterogeneity.


Effects of stimulating or destroying the deep cerebellar regions in man.


Atypical myelomeningocele with associated anomalies. Case report.


Compression of the trachea by an anomalous innominate artery.


(Macht D),+MACHT D: Who is this doctor?

(Macht D),+MACHT D: Who is this doctor?


Newer concepts in electrical pacing of the heart.


The past in the present. A column on history.


Inactivation of a newly transferred gene in recombination-deficient recipients of Escherichia coli.


Classification and intragenic position of mutations in the beta-galactosidase gene of Escherichia coli.


'Instant' inhibition of lactation.

'Instant' inhibition of lactation.


An assessment of quinestrol in the inhibition of lactation.


Treatment of hypertension with quinethazone alone or in combination with reserpine.


Disodium cromoglycate in asthma.

Disodium cromoglycate in asthma.


Edward Jenner. The Cheltenham years (1795-1820).


The detection of antibodies to M. Johnei by immunofluorescence.


Recommended minimun standards for detecting hog cholera viral antigen by the fluorescet antibody tissue section technique.


Fluorescent antibody procedures for bovine viruses.


Toxoplasmosis review and assessment.

Toxoplasmosis review and assessment.


Recommended minimum standards for the isolation and identification of hog cholera by the fluorescent antibody-cell culture technique.


A direct fluorescent antibody technique for the examination of animal byproducts, food and feeds for salmonella. A preliminary study.


A search for cooperative infection of P1-lysogenic Escherichia coli by restricted lambda phage.


On the role of ligase in genetic recombination in bacteriophage T4.


Leakage at suture lines after partial gastrectomy for peptic ulcer.


The uptake of (6,7-3H) 17beta-oestradiol by tissues of the domestic fowl during an ovulation cycle.


The determination of arsenic in organic and inorganic arsenic compounds: a radioisotope-dilution substoicheiometric application.


Symposium: Hemoglobinopathies in Japan. Historical retrospect of its survey.


Wilburt Cornell Davison, M.D. Some introductory remarks.


The basis of Sir William Osler's influence on medicine.


Dextroamphetamine sulfate in children with learning disorders. Effects on perception, learning, and achievement.


Cyprolidol and imipramine: a double-blind controlled study in endogenous depression.


Hemoglobin-coated charcoal radioassay for serum vitamin B12. A simple modification to improve intrinsic factor reliability.


Codeine and its alternates for pain and cough relief. 3. The antitussive action of codeine--mechanism, methodology and evaluation. This report-the third of a series on codeine and its alternates for pain and cough relief-presents a detailed review of the physiology and pathophysiology of cough, the methods for the experimental and clinical measurement of the antitussive action of drugs, possible mechanisms of action of antitussive agents, and includes a compilation of experimental results and clinical experience with codeine as an antitussive.


The design and building of Mr. Guy's Hospital.


Left ventricular blood supply from sources other than left coronary artery.


The aetiology and pathogenesis of multiple sclerosis.


The sliding skin-flap graft operation for hemorrhoids: a modification of the Whitehead procedure.


Ventilatory response to unilateral pressure breathing of intact and reimplanted lungs in dogs.


Comparison of cardiac outputs from femoral artery and arteriovenous shunts.


Leiomyosarcoma of the rectum: report of two cases.


Studies on the RNA polymerase in Escherichia coli K12 using the mutation affecting its activity.


Low anterior resection in the community hospital.


Genetic transformation in Escherichia coli.


Consequences of deletion mutations joining two operons of opposite polarity.


Fate of the message-ribosome complex upon translation of termination signals.


Plastic relief of anal stenosis.

Plastic relief of anal stenosis.


The maturing kidney. A modern view of well-balanced infants with imbalanced nephrons.


Changes in drug resistance of shigellae, salmonellae and Escherichia coli.


Metabolic products and their chemical regulations in plant tissue cultures.


Proper principles and practices in the surgical management of hemorrhoids.


Cytology of skin reactions to different inoculated substances (tuberculin, streptokinase, lipopolysaccharide of S. typhi, phytohaemagglutinin and pokeweed mitogen).


Heparin and antifibrinolytic agents during experimental hepatectomy and liver transplantation.


Dermatological photobiology.

Dermatological photobiology.


Plague.

Plague.


A short history of plastic surgery.

A short history of plastic surgery.


History of the Mater Infirmorum Hospital.


A computerized geometric analysis of human dental arch form.


Presentation of special issue of the American Journal of Orthodontics in honor of Dr. Harvey Carlyle Pollock, Sr.


Development of immunity in fetal dogs: skin allograft rejection.


Bovine viral diarrhea virus-host cell interactions: adaptation, propagation, modification, and detection of virus in rabbits.


Bovine viral diarrhea virus-host cell interactions: adaptation and growth of virus in cell lines.


Effects of overpressure on the ear--a review.


The scope of blast and shock biology and problem areas in relating physical and biological parameters.


Circulating lipoproteins.

Circulating lipoproteins.


The call of science.

The call of science.


Synthetic lipid bilayer membranes.

Synthetic lipid bilayer membranes.


Catalytic functions of thiamin diphosphate.


Cell membranes: structure and synthesis.


Regulation of amino acid metabolism.

Regulation of amino acid metabolism.


Biochemical aspects of high-resolution mass spectrometry.


Structure and biosynthesis of the bacterial cell wall.


Conformation of polypeptide chains.

Conformation of polypeptide chains.


Clinical biochemistry: enzymatic methods: automation and atomic absorption spectroscopy.


The biochemistry of learning: an evaluation of the role of RNA and protein.


Messenger RNA.

Messenger RNA.


Chemical approaches to the properties of active sites of enzymes.


Recognition of nucleotide sequences.

Recognition of nucleotide sequences.


Chromosomal proteins.

Chromosomal proteins.


In vivo and in vitro methods of measuring nutritive value of leaf-protein preparations.


An Eighteenth Century treatise on dropsy of the chest (Buchner, 1742).


Lewis Albert Sayre, the first professor of orthopaedic surgery in the United States. (1820-1900).


Henry Gasset Davis, a founder of American orthopaedic surgery. (1807-1896).


DeForest Willard, Philadelphia's pioneer orthopaedic surgeon (1846-1910).


Maimonides the physician: a bibliography.


Studies on microbial RNA. Properties of tRNA methylases from Saccharomyces cerevisiae.


Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae.


Double conditional lethality: temperature-sensitive and amber mutations in the glucosyl transferase gene of bacteriophage T2.


Anterior and posterior groups of portal vessels in the avian pituitary.


The history of medical and surgical interests in facial pain.


A four year double-blind study of tegretol in facial pain.


A long-term low-dosage study of carbamazepine in trigeminal neuralgia.


Clinical trials of tegretol in trigeminal neuralgia.


Simple anaerobic technique for the treponema pallidum immobilization test.


Non-surgical treatment of tic douloureux with carbamazepine (G32883).


Comparative diagnostic methods for detecting lactate utilization by Corynebacterium acnes.


Allograft rejection and thymic activity in the pig.


The ultrastructure of normal pre-vertebral sympathetic ganglia in the cat.


Artifacts in mono-amine oxidase histochemistry.


A selection of Harvey Cushing anecdotes.


The tape-closed wound--a bioengineering analysis.


The effect of excess methionine on the pancreas. A light and electron microscopic study in the Chinese hamster with particular reference to degenerative changes.


Measurement of pulmonary surfactant by Du Nuoy tensiometer in various physiopathological conditions.


Induction of DNA breakdown and death in Escherichia coli by phleomycin. Its association with dark-repair processes.


Host-cell reactivation of gamma-irradiated phage T1 in strains of Escherichia coli K-12.


Francis John Gwynne.

Francis John Gwynne.


Field trials with an ovine Salmonella vaccine.


The biochemical basis of long-term memory.


The metabolism of contact insecticides in stored grains.


Spectrophotofluorescent and spectrophotophosphorescent data on insecticidal carbamates and the analysis of five carbamates in milk by spectrophotofluorometry.


Residue behavior of polynuclear hydrocarbons on and in oranges.


Chromogenic spray reagents for the organophosphate pesticides.


The significance of blood cholinesterase activity measurements.


Advances in gas chromatographic detectors illustrated from applications to pesticide residue evaluations.


Solvent purification for residue analysis by non-distillation methods.


The "acceptable daily intake" value as a base for legislative measures regarding food additives.


Effects of some pesticides and related compounds on steroid function and metabolism.


Pesticide residues on tobacco.

Pesticide residues on tobacco.


Plastic skin chamber technique for comparative studies on localized leukocyte mobilization in man.


The development of plasma cells in antigen stimulated rabbit blood lymphocyte cultures.


Outflow paths of cells from the lymph node parenchyma to the efferent lymphatics--observations in thin section histology.


Hormonal stimulation of lactose synthetase in mammary carcinoma. A transplantable rat mammary carcinoma (R3230AC) synthesizes significant quantities of the mammary gland enzyme lactose synthetase in the immature virgin female rat. In this hormonal environment, mammary glands do not synthesize the enzyme. Prolactin further stimulates the enzyme activity in the tumors to levels found only in mammary glands of rats in late pregnancy or during lactation.


A tribute to Peter C. Kronfeld.

A tribute to Peter C. Kronfeld.


Study on the toxoids against the venoms of certain Asian snakes.


Effect of Escherichia coli endotoxin on locomotor activity of mice.


The physician's responsibility in management of food and fluid intake.


Escherichia coli epidemiology, 1960-1968.


Dr. John Shaw Billings and The American Climatological Association.


Drugs and the Washington climate.

Drugs and the Washington climate.


Memorial. L. Whittington Gorham, M.D.

Memorial. L. Whittington Gorham, M.D.


Memorial. Harry Walker. M.D.

Memorial. Harry Walker. M.D.


Memorial. Edward Newman Packard. M.D.

Memorial. Edward Newman Packard. M.D.


Memorial. Lawrence Kirby Lunt. M.D.

Memorial. Lawrence Kirby Lunt. M.D.


Memorial. Thomas Preston White. M.D.

Memorial. Thomas Preston White. M.D.


Memorial. Hubert Willows Hetherington, M.D.


A critique of the biological contributions of Leonardo da Vinci.


Unintentional filtration following cataract surgery.


Therapeutic keratoplasty in Fuchs' dystrophy.


Russia on the Pacific Coast.

Russia on the Pacific Coast.


Autograft rejection. I. Effect of prior transplantation to allogeneic and xenogeneic hosts.


The ocular immune response. II. Immune rejection of penetrating corneal homografts. Early versus late treatment with antilymphocyte serum.


Relationship of platelets, blood coagulation, and fibrinolysis to hyperacute rejection of renal xenografts.


An attempt to produce low-zone tolerance to tissue alloantigens.


Formazan production: test for tissue viability prior to transplantation.


Influence of the Ag-B locus on reactivity to skin homografts and tolerance responsiveness in rats.


Five congenic resistant lines of rats differing at the Rt H-1 locus.


Longevity of AKR mice increased by reduced incidence of thymic lymphomas. A preliminary report.


Primary malignancy in patients undergoing immunosuppression for renal transplantation.


Escherichia coli products in enteritis.

Escherichia coli products in enteritis.


Historical perspectives of the ethical practice of psychiatry.


Some random recollections of Stanley Cobb.


Pharmacology and toxicology of propellant hydrazines.


Diphenylhydantoin in neurotic anxiety.

Diphenylhydantoin in neurotic anxiety.


Titus Holliday Harris 1892-1969.

Titus Holliday Harris 1892-1969.


An investigation into the verbal facility of hydrocephalic children, with special reference to vacabulary, morphology and fluency.


Vertebral and other abnormalities in parents and sibs of cases of spina bifida cystica and of anencephaly.


Preliminary report on a combined early physical and surgical approach to deformed feet in spina bifida.


The results of early treatment of extreme hydrocephalus.


Therapeutic and prophylactic lengthening of distal catheter of the holter ventriculo-atrial shunt.


Early embryogenesis of the central nervous system with special reference to closure defects.


Studies on the embryogenesis of spina bifida in the rat.


Extrachromosomal inheritance in bacteria.


The position of the spinal cord segments related to the vertebral bodies in children with meningomyelocele and hydrocephalus.


Self-assembly of biological structures.

Self-assembly of biological structures.


Hemimyelocele.

Hemimyelocele.


The pathophysiology of the bladder in myelomeningocele and its correlation with the neurological picture.


Treatment of persistent urinary tract infections with gentamicin.


Antimicrobial properties of the pyrithione salts. VII. In vitro methods for comparing pyrithiones to standard antimicrobials.


Proteins--new sources and new problems.

Proteins--new sources and new problems.


Suitability of cell cultures for carcinogenicity tests.


Ontogeny of the immune response to skin allografts in relation to lymphoid organ development in the amphibian Xenopus laevis Daudin.


Mechanism of protein biosynthesis.

Mechanism of protein biosynthesis.


Roster of members. Indiana State Medical Association and Woman's Auxilary.


Specific interaction of an initiator tRNA fragment with 30 s ribosomal subunits.


The effects of different isolation media on the respiration and morphology of housefly sarcosomes.


An analysis of "revertants" of a deletion mutant in the C gene of the L-arabinose gene complex in Escherichia coli B-r: isolation of initiator constitutive mutants (Ic).


Starting nucleotide sequences of RNA synthesized on the replicative form DNA of coliphage fd.


Escherichia coli: reversion from streptomycin dependence, a mutation in a specific 30 s ribosomal protein.


Man medicine, and work in America: an historical series. IV. Thomas Cadwalader, M.D. physician, Philadelphian and philanthropist.


Cardiology. The challenge of prevention.


Diet high in unsaturated fat. A controlled clinical trial.


Compiler of the thesaurus. Peter Mark Roget, M.D., F.R.S. (1779-1869).


Localization of venom antigens in the venom gland of Vipera plaestinae using a fluorescent-antibody technique.


Sir James Mackenzie and his polygraph. The contribution of Louis Faugeres Bishop, Sr.


Antepartum thrombophlebitis complicated by hyperuricemia, uremia, and polyhydramnios.


Hypercalcemic crisis in acute leukemia.

Hypercalcemic crisis in acute leukemia.


Artificial abortion at midpregnancy by mechanical stimulation of the uterus. A review of 20 years' experience with current methods in Japan.


Pulmonary arteriovenous fistula. Diagnosis and prognosis in noncomplainant patients.


Evolution of pain theories.

Evolution of pain theories.


Respiratory pharmacology of mixtures of scopolamine with secobarbital and with fentanyl.


VI. Sensory mechanisms and multi-factor models in the regulation of food and water intake. Mechanisms in the control of food and water intake.


Inhibition by pactamycin of the initiation of protein synthesis. Binding of N-acetylphenylalanyl transfer ribonucleic acid and polyuridylic acid to ribosomes.


The anthranilate synthetase-5-phosphorylribose 1-pyrophosphate phosphoribosyl transferase complex of the tryptophan pathway in Salmonella typhimurium. Purification by the in vitro assembly of its subunits.


Inhibition by pactamycin of the initiation of protein synthesis. Effect on the 30S ribosomal subunit.


Stabilization of N-acetylphenylalanyl transfer ribonucleic acid binding to ribosomes by sparsomycin.


Phenylalanine transfer ribonucleic acid from Escherichia coli B. Isolation and characterization of oligonucleotides from ribonuclease T-1 and ribonuclease A hydrolysates.


Conformational changes in glutamine synthetase from Escherichia coli. I. The binding of Mn2+ in relation to some aspects of the enzyme structure and activity.


Conformational changes in glutamine synthetase from Escherichia coli. II. Some characteristics of the equilibrium binding of feedback inhibitors to the enzyme.


Mechanism and prevention of fixed vascular resistance in transplanted lungs: survival with simultaneous contralateral pulmonary artery ligation.


Pulmonary mechanics and surface tension in the canine lung following autotransplantation.


Estimation of hepatic blood-flow (E.H.B.F.) with experimental alterations of extra-hepatic circulation.


Heart transplant rejection in pig and dog.


Regeneration of nerves after lung autotransplantation.


Michigan Dental Hygienists' Association membership directory.


Psychoactive drugs in the treatment of emotionally disturbed children: haloperidol and diazepam.


Citation for William Andy Mills.

Citation for William Andy Mills.


Death following injection of neostigmine by R.R. Macintosh.


A controlled clinical trial comparing the diuretic ethacrynic acid and furosemide in patients with congestive heart failure.


Myasthenic crisis. Therapeutic use of d-tubocurarine by H. C. Church-Davidson and A. T. Richardson.


The classic. On a new kind of Rays.

The classic. On a new kind of Rays.


Neoplasms of the stomach other than carcinoma with report of a case.


The use of intravenous tyramine and the cold pressor test to help elucidate a possible mechanism of action of a new isoquinoline compound shown to have antihypertensive properties in humans.


Initial rate studies of adenylosuccinate synthetase with product and competitive inhibitors.


The effect of amino acid analogues on alkaline phosphatase formation in Escherichia coli K-12. IV. Substitution of canavanine for arginine.


Tryptophanyl transfer ribonucleic acid synthetase from bovine pancreas. 3. A complex of tryptophanyl transfer ribonucleic acid synthetase and transfer ribonucleic acid that accepts tryptophan: the purification of 32 P-tryptophan transfer ribonucleic acid.


The American Orthopaedic Association: yesterday, today, and tomorrow.


John J. Cushner, M. D. 1910-1968.

John J. Cushner, M. D. 1910-1968.


Dark profiles in the apparently-normal central nervous system. A problem in the electron microscopic identification of early anterograde axonal degeneration.


Computer applications in nuclear medicine.


Letter to the editor: a case of unexplained gingivitis.


Persistence of the autoimmune pathogenetic process in experimental autologous immune complex nephritis.


Chronic bacteriuria due to Escherichia coli. II. Correlation of microbiological, and biochemical findings with the clinical results.


Comparative studies on the ultrastructure of the thyroid parafollicular C-cells.


1969 membership roster Southern California Dental Asociation.


John Warren (1753-1815), first Harvard surgeon.


Treatment of bronchial asthma with cromolyn.


Recurrent urinary tract infections in children: clinical approach to diagnosis and treatment.


The measurement of phenylalanine and tyrosine in blood.


Hemangioma of the placenta associated with fetal anemia and edema. Report of a case.


Abnormal sex chromosomes and mental disorders.


Monoamniotic hydrocephalic twins with survival. Report of a case with cytogenetic study.


Hereditary factors in obstetrics and gynecology.


Stereological studies on several ducts and vessels by injection method of acrylic resin. 23. Arterial distribution of the medial pterygoid muscle in some mammals.


Sites and modes of action of antipyretic-analgesic drugs.


Malignant destruction of the axis. Two-year survival.


John Hunter and cardiopulmonary resuscitation.


Myocardial revascularization.

Myocardial revascularization.


Body composition estimates derived from potassium measurements. ANL-7461.


Microsurgery of otosclerosis: prefabricated wire-gelfoam prosthesis.


Climatology and medicine. IV.

Climatology and medicine. IV.


Illusory correlation as an obstacle to the use of valid psychodiagnostic signs.


The asthmatic and his environment.

The asthmatic and his environment.


Thomas Mann's Death in Venice.

Thomas Mann's Death in Venice.


Thalamic correlated of language and speech.


The biological basis of clinical and experimental organ transplantation.


Practical problems in kidney transplantation.


Late results with kidney transplantation.


Experimental and clinical use of antilymphocytic serum in kidney transplantation.


The pathophysiology of the transplanted cadaver kidney.


The role of biomechanical factors in the pathology of bone transplantation.


The experience with the bone preserves in Algeria.


Respiratory allergy and climatic conditions. I. Review.


Three cases of gastrointestinal bleeding following burns.


Post-operative wound sepsis in general surgery. I. Material, methods and frequency.


Post-operative wound sepsis in general surgery. 3. An evaluation of the post-operative administration of antibiotics.


Acta Chirurgica Scandinavica.

Acta Chirurgica Scandinavica.


Hemodynamic effects of partial hepatectomy in dogs.


Microangiographic investigations on acute appendicitis.


Diagnosis of infectious mononucleosis by the monospot test.


A serologic study of Herellea vaginicola and its identification by immunofluorescent staining.


A case of cerebral abscess with haemophilus aphrophilus cultured from spinal fluid.


In memoriam James H. Park, M.D. 1897-1968.


Studies on the hematology of certain freshwater teleosts. V. Thrombocytes and clotting of blood.


The survival of bacterial cells pulse-irradiated under various oxygen concentrations.


100 years of psychiatry (Kraepelin)--50 years later.


Nordiskt Medicinskt Arkiv--Acta Medica Scandinavica, 100 years.


Behavioral antecedents of adult schizophrenia. A review.


Personality and intelligence in Turner's syndrome. A critical review.


Fear of death and fear of life. The dilemma in chronic renal failure, hemodialysis, and kidney transplantation.


Hodgkin's disease in Norway. Mortality trends, incidence, and survival.


Calcium metabolism and osteodystrophy after renal transplantation.


Invited discussion.

Invited discussion.


Serologic reactivity in consecutive patients admitted to a general hospital. A comparison of the FTA-ABS, VDRL, and automated reagin tests.


Pleural fluid in rheumatoid pleuritis. Patient summary with histopathologic studies.


Modification of the limbal approach to surgery of the rectus muscles.


Human corneal donor material. In-vitro studies.


Strabismus.

Strabismus.


Method of oral hygiene in certain difficult problems.


Blood volume following spinal cord injury.


Treatment of herpes simplex with ultrasound: preliminary report.


The growth and development of rehabilitation medicine.


Brain barrier phenomena.

Brain barrier phenomena.


Circulation in rat skeletal muscle during rest and activity.


Experimental myocardial infarction in the dog. Comparison of myocardial blood flow within, near, and distant from the infarct.


Input-output analysis for total input rate and total traced mass of body cholesterol in man.


Effects of saline loading on the renin, erythropoietin, and blood pressure responses to canine renal allotransplantation.


Blood flow in cutaneous tissue in man studied by washout of radioactive xenon.


I sex factors and chromosomal recombination in Salmonella typhimurium.


Projections from the orbital gyrus in the cat. I. To brain stem structures.


Oral structure development and nuclear behavior during conjugation in Paramecium aurelia.


An analysis of clumping in the soil amoeba Mayorella palestinensis.


The fine structure of Trypanosoma congolense in its bloodstream phase.


François Joseph Victor Broussais (1772-1838). System of physiological medicine.


The Institute of Pathology, 1897-1952.

The Institute of Pathology, 1897-1952.


Bacterial shock.

Bacterial shock.


Pneumocystis pneumonia transmission between patients with lymphoma.


Characteristics of anterior filling materials used in pedodontics.


The Institute of Pathology, 1879-1897.

The Institute of Pathology, 1879-1897.


Healing following tooth replantation.

Healing following tooth replantation.


The Institute of Pathological Anatomy, 1952-1968.


Hygiene and bacteriology 1893-1940.

Hygiene and bacteriology 1893-1940.


How the house was made.

How the house was made.


The Institute of Forensic Medicine, 1938-1967.


Augmentation mammaplasty in micromastia.


The influence of a vasodilator on the revascularization of a skin graft.


Pre-operative traumatic congestion and composite skin-fat grafting. An experimental study.


Retrolental fibroplasia.

Retrolental fibroplasia.


Formation of valyl- and isoleucyl-sRNA synthetases in a valine-requiring mutant of Escherichia coli.


Formation of aminoacyl-sRNA synthetases during growth phases of Escherichia coli.


Organ-specific antibodies in idiopathic panhypopituitarism, primary thyroid and adrenal insufficiency.


Scientific thinking and clinical research.


47, XYY bibliography.

47, XYY bibliography.


The susceptibility of the alpha-l and alpha-2 components of collagen to pepsin.


Effect of excess L-thyroxine on the hypothalamus of thyroidectomized rat.


Studies on the fate of 3H-noscapine in mice and rats.


Methodology of eye pressure measurement.


The determination of the molecular weight of ribonucleic acid by polyacrylamide-gel electrophresis. The effects of changes in conformation. 1. The effects of changes in experimental conditions on the mobility of RNA in polyacrylamide-gel electrophoresis were investigated. 2. The linear relation between log(molecular weight) and electrophoretic mobility was shown to be independent within limits of salt or gel concentration. 3. The relative mobility of RNA with low content of guanylic acid and cytidylic acid residues was decreased in low-ionic-strength buffer. This was related to a small relative decrease in sedimentation coefficient. 4. However, Mg(2+) ion caused almost no increase in mobility although it was associated with large increases in sedimentation coefficient. This suggested opposing actions of Mg(2+) ion on the size and effective charge of the RNA. 5. It is concluded that the method provides a satisfactory measurement of molecular weight, which is almost independent of the nucleotide composition of RNA at moderate salt concentrations.


Haematological consequences of major surgery.


Transient (reversible) malabsorption of vitamin B12.


Transplantation antigens in man: their recognition and relevance in clinical organ transplantation.


Sagredo's optical researches.

Sagredo's optical researches.


Steps in the reproductive process susceptible to regulation. During the past decade, family-planning programmes have been conducted on the assumption that developments in the field of contraception (e.g., hormonal contraceptives and intra-uterine devices) had reached a stage of considerable technical perfection. Enough information has now been accumulated, however, to indicate that this assumption was not fully justified; the high drop-out rates from these programmes observed under different conditions indicate that there is an urgent need for further improvements of the existing methods and for the development of new methods based on different approaches. A prerequisite for the development of such methods is a greatly improved knowledge of the physiological factors influencing the various steps of the reproductive processes in the human species.In an attempt to focus attention on the various steps which are susceptible to controlled interference, a brief review is given of some of the present concepts of the regulation of spermiogenesis, ovulation and the menstrual cycle, sperm capacitation, fertilization, tubal passage, zygote and blastocyst formation, implantation and early embryonic development. It is concluded that the reproductive processes are indeed subject to intricate biochemical and hormonal regulatory mechanisms and that the different phases of these processes do offer a variety of possibilities for hormonal, pharmacological and perhaps also immunological interference.


Spectrum and iron content of protein B2 from ribonucleoside diphosphate reductase.


Purification and properties of a trypsin inhibitor from barley.


Optical rotatory dispersion and circular dichroism in structural and stereochemical studies.


Stereochemical correlations.

Stereochemical correlations.


Ribonucleoside diphosphate reductase. Purification of the two subunits, proteins B1 and B2.


Professor Roelof Prakken Emeritus.

Professor Roelof Prakken Emeritus.


Directory.

Directory.


Preparation of tissues for localization of sex hormones by autoradiography. I. Loss of radioactive material effected by the use of some conventional methods.


Nutrition research in Britain.

Nutrition research in Britain.


Preparation of tissues for localization of sex hormones by autoradiography. II. The loss of radioactive material in embedding media after freeze drying and vapour fixation of the tissues.


Subunit structure of L-arabinose isomerase from Escherichia coli.


Isolation and characterization of Clostridium botulinum type B toxin.


Acyl carrier protein. XI. The specificity of acyl carrier protein synthetase.


The specificity of S-adenosylmethionine derivatives in methyl transfer reactions.


Study on the hepatic circulation. I. A method for the measurement of the ratio of hepatic arterial and portal flow with the electric conductivity method.


Study on the hepatic circulation. II. The relation of hepatic artery and portal vein under hypoxia and pulmonary embolism.


The social sciences' need for illustration.


The extinction of the Tasmanians.

The extinction of the Tasmanians.


Sensitization of bacteria to x-ray by neoarsphenamine.


Experimental infections of calves with Trichostrongylus axei investigations using abomasal cannulae.


Amino acid utilization in the ruminant.

Amino acid utilization in the ruminant.


In memoriam Erna Christensen (18.11.1906--28.11.1967).


Hexosamine in normal and pathological nerve tissue.


Trichotillomania in children: a review.

Trichotillomania in children: a review.


Ionic composition of the arterial wall.

Ionic composition of the arterial wall.


Psychological aspects of the stereotactic treatment of Parkinsonism.


A comparison of two drug treatments in depressive illness.


Walt Whitman, May 31, 1819--March 26, 1892. Sesquicentenary recollections.


Serum pepsinogen activity and the diagnosis of bovine ostertagiasis.


Biopsy procedures in clinical medicine.

Biopsy procedures in clinical medicine.


A computer-controlled stereotaxic system.


Placement of gross electrodes and infusion needles in the brain in acute animal experiments.


Initial events caused by colicin K infection--cation movement and depletion of ATP pool.


Endothelial inclusions in active lesions of systemic lupus erythematosus.


Studies on the reliability of the isotopic calcium absorption test in patients with chronic renal disease.


Acid-base and electrolyte changes induced by acute isotonic saline infusion in the nephrectomized dog.


The effect of hemodialysis, vitamin D, and renal homotransplantation on the calcium malabsorption of chronic renal failure.


Improved method for electronic counting of platelets.


Correlation between degradation of bacteriophage T2 deoxyribonucleic acid and the resistance of Escherichia coli to infection. The ability of certain strains of Escherichia coli to degrade T2 deoxyribonucleic acid to acid-soluble fragments is correlated with their high capacity to survive T2 infection.


Abortive infection of Shigella dysenteriae P2 by T2 bacteriophage. We have investigated some of the biochemical events that accompany the abortive infection by T2 of Shigella dysenteriae lysogenized with the temperate phage P2. After infection with T2, protein and RNA synthesis continued for 3 to 5 min. The virus-induced enzyme, deoxycytidylate hydroxymethylase was produced in reduced amounts (15% of normal), and the extent of deoxyribonucleic acid (DNA) synthesis was 0.1% of that found with a nonlysogenic strain. Measurements of the production of acid-soluble fragments and sedimentation analyses failed to detect enzymatic degradation of the infecting viral DNA which could be specifically related to the presence of the prophage P2. Each interaction between T2 and a bacterium resulted in the death of the cell. This observation is consistent with results obtained with other types of bacteria which show that only when a nucleolytic attack occurs on T2 DNA does the cell have an increased capacity to survive after adsorption of T2.


Planned pre-operative irradiation for carcinoma of the larynx and laryngopharynx treated by total and partial laryngectomy.


Directory of otolaryngologic societies.

Directory of otolaryngologic societies.


Ribosomal subunits and MS2 phage RNA-directed protein synthesis.


Moloney leukaemia virus as a helper in retrieving Friend virus from a non-infectious reticulum cell sarcoma.


A short history of Minamata disease research and the present situation of mercury pollution in Japan.


Experiences with pancreaticoduodenal allotransplantation.


Influence of natural opsonins on the kinetics of phagocytosis of sheep red blood cells and S. typhimurium in the mouse.


Fluorescence microscopy and microspectrofluorimetry of malignant melanomas, naevi and normal melanocytes.


Cilia and other surface structures of the trochophore of Harmothoë imbricata (Polychaeta).


Electron microscopy of degeneration in the lateral olfactory tract and plexiform layer of the prepyriform cortex of the rat.


Macrophages containing langerhans cell granules in normal lymph nodes of the rabbit.


Ultrastructural features of human spermiogenesis.


The temporomandibular joint and the hearing apparatus. The need for positive research in the area of temporomandibular joint and the hearing apparatus.


Influence of temperature on glucose utilization by Pseudomonas fluorescens. The influence of temperature on the conversion of glucose into cell material and into energy for maintenance was determined for Pseudomonas fluorescens by a steady-state turbidity method and by a substrate utilization method. Conversion of glucose into cell material was measured as yield; conversion of glucose into energy for maintenance was measured as specific maintenance, the minimum dilution rate in continuous culture below which a steady state is not possible. The values obtained by the two methods were nearly identical; with both, the yield and specific maintenance decreased with decreasing temperature. The specific maintenance consumption rate (milligrams of glucose taken up per milligram of cell dry weight per hour at zero growth) was also calculated by the substrate utilization method and found to decrease with decreasing temperature. However, the amount of glucose consumed per generation for maintenance increased with decreasing temperature. This increased glucose consumption for maintenance may provide a partial explanation for the decrease in yield at low temperatures. Small amounts of glucose were also converted into pigment at all temperatures tested, with the greatest amount formed at 20 C.


Four-hour urease test for distinguishing between Klebsiella and Enterobacter. Infections with Klebsiella and Enterobacter have increased among hospitalized patients. To study such infections, relatively simple but precise methods are needed for clinical laboratories to identify the two genera accurately. Moreover, a rapid identification is essential for assisting with the therapy of the patients. For this purpose, a new 4-hr urease test was developed so that colonies could be tested directly from blood-agar plates which have been inoculated with clinical material and allowed to incubate overnight. This 4-hr test was positive with 98.5% of 202 Klebsiella species and negative with 80 Enterobacter species. As a single criterion for distinguishing between the two major genera, the new 4-hr urease test was just as accurate as a motility test (99% of the 282 isolates were accurately identified with either). The 4-hr urease test represents a simple, rapid, and reliable technique which is ideally suited for use in clinical microbiology laboratories.


Microbiological evaluation of Pacific shrimp processing. Microbiological evaluation of Pacific shrimp (Pandalus jordani) processing was made from samples obtained at five key processing points. The microbial count of raw shrimp ranged from 1.3 x 10(6) to 3.0 x 10(6). The initial microbial flora, in order of predominance, was Acinetobacter-Moraxella, Flavobacterium, Pseudomonas, gram-positive cocci, and Bacillus species. No yeasts were isolated. Differences in processing practices influenced both microbial count and the shrimp flora. The microbial load, however, always increased after peeling and sorting operations and decreased after cooking, washing, and brining steps. Significantly, the gram-positive cocci were recovered with increasing frequency after each processing step, reaching 76% of the total load in a final product. Most of them, however, were coagulase-negative.


Time, cost, and efficacy study of identifying group A streptococci with commercially available reagents. During the 12-month period primary throat, wound, and skin cultures, tentatively identified as B streptococci, were submitted by 10 different clinical laboratories for evaluation. A total of 692 beta-hemolytic streptococci were isolated from cultures submitted and examined in parallel by the fluorescent-antibody, precipitin, and bacitracin techniques. An evaluation of the specificity and sensitivity in conjunction with basic and personnel costs was determined for each method. The standard Lancefield precipitin method was established as the standard by which the bacitracin and flourescent antibody techniques were compared. With some variation depending on the commerical source of the disc, approximately 7% of the strains examined produced false reactions with the bacitracin disc. False-negative reactions were rarely noted by the group A fluorescent antibody technique (0.5%), but an appreciable number of other Lancefield groups (B, C, and G) were nonreactive with homologous conjugates.


Klebsiella, Enterobacter, and Serratia: biochemical differentiation and susceptibility to ampicillin and three cephalosporin derivatives. Three hundred twenty-nine strains of the tribe Klebsielleae were compared by several biochemical tests and by susceptibility to selected antibiotics. Biochemical tests included urease, amino acid decarboxylase, and hydrogen sulfide production; fermentation of lactose and dextrose; motility; and tests in the IMViC (indole, methyl red, Voges-Proskauer, citrate) series. The isolates were: Klebsiella species, 67.5%; Enterobacter species, 28%, and Serratia species, 4.5%. Minimal inhibitory concentrations of cephaloridine, cephalothin, and a new cephalosporin, cephalexin, and of ampicillin were determined by the agar dilution procedure. Cephalosporins at 20 mug/ml or less inhibited 90% of the Klebsiella strains but only 15% of the Enterobacter strains. Ampicillin inhibited 27% of Enterobacter strains and 17% of Klebsiella strains. Serratia isolates were insensitive to the cephalosporins and ampicillin. The results suggest that precise identification of this group to the generic level can be accomplished readily in the clinical laboratory and that such information is helpful in the preliminary selection of an antibiotic for treatment of clinical infections.


Micro test for streptococcal anti-deoxyribonuclease B. A methyl green decolorization micro test for the determination of streptococcal anti-deoxyribonuclease B titers in serum is described. The micro test was compared with an alcohol precipitation macro test on 112 human sera. The anti-deoxyribonuclease B titers agreed within one dilution step for 85.7% of the 112 sera examined by both techniques. Both tests were about equal in the detection of titers above the upper limits of normal. The micro test requires smaller amounts of reagents and fewer man-hours to perform than the macro test. This translates into lower cost per test and more tests per man-hour.


Growth of Bacteroidaceae in stirred fermentors. The conditions for increasing bacterial yields in cultures of Bacteroidaceae by the use of stirred fermentors and pH control were investigated by means of three representative species: Sphaerophorus necrophorus, Bacteroides fragilis, and B. melaninogenicus. A medium containing tryptone, yeast extract, and glucose or sucrose was used. Horse serum had to be added to obtain substantial growth of B. melaninogenicus. The optimal pH for growth rate and yield was 7.0 to 7.2. Lysis of the bacteria occurred when the glucose (or sucrose) was exhausted. The rate of lysis was very high in cultures of S. necrophorus, less so in B. fragilis and B. melaninogenicus. Pleomorphism, manifested as large sperical forms of the bacteria, was observed in the late logarithmic phase of S. necrophorus. Great differences in the length of the lag phase and of the mean generation time were found among the three bacterial species. The yield in static cultures of the three species without pH control was approximately 0.4 g of dry cells per liter, but was increased, in stirred fermentors with pH control, to 3.5 g (S. necrophorus), 2.7 g (B. fragilis), and 4.3 g (B. melaninogenicus) per liter. With an inoculum density of 5 to 10 mg (dry weight) per liter, these yields were obtained in approximately 10 (S. necrophorus), 25 (B. fragilis), and 35 hr (B. melaninogenicus), respectively.


Persistence of Salmonella typhimurium on fabrics. The persistence of Salmonella typhimurium (V-31) on wool blanket, wool gabardine, cotton sheeting, cotton knit jersey, cotton terry cloth, and cotton wash-and-wear fabrics was studied. Three methods of exposure were employed to contaminate the fabrics: direct contact, aerosol, and a lyophilized mixture of bacteria and dust having a high content of textile fibers. After contamination, the fabrics were held in 35 or 78% relative humidity at 25 C. The persistence time of S. typhimurium on fabrics held in 35% relative humidity was substantially longer when the fabrics were contaminated by direct contact or by exposure to dust containing bacteria than when contaminated by exposure to aerosolized cultures. Viable bacterial populations persisted for 24 weeks at relatively high population densities on swatches of wool gabardine, cotton sheeting, cotton knit jersey, and cotton terry cloth exposed by direct contact and held in a humidity of 35%. In 78% humidity, bacterial populations persisted on the fabrics for relatively shorter periods of time regardless of the mode of contamination or fabric type. This organism retained its virulence for Swiss mice after being recovered from wool gabardine swatches held 8 weeks in humidities of 35 or 78% and from cotton terry cloth swatches held 6 weeks in the same humidities.


Area-sampling technique for quantitative pharyngeal cultures. An area-sampling device for obtaining quantitative samples of the oropharyngeal bacterial flora is described and illustrative data are presented.


5-azacytidine: microbiological assay in mouse blood. A 6-chloropurine-resistant strain of Escherichia coli has been used to develop a microbiological assay for the estimation of 5-azacytidine distribution in mouse tissues.


Effect of cultural environment on the blood group activity of microorganisms. Blood group activity was proven to be a property of the bacterium per se which possesses it, although such activity was influenced by the cultural environment of the organism. High concentrations of peptones having blood group activity were able to transfer this activity to inactive organisms; however, the conferred activity was proportional to the concentration. As a result of the low concentrations, the blood group activity of peptones was eliminated upon incorporation in culture media, and the activity of the peptones had no effect on the blood group activity levels of microorganisms when grown in these media. Conversely, the vitamin content of culture media did affect blood group active organisms. Multiple vitamins in media decreased the activity levels by blocking the reactive sites of the active organisms on which activity detection depended. Blood group activity levels were highest in media of minimal or no vitamin content. Therefore, it can be concluded that a choice of cultural medium becomes an important factor in the quantitation of bacterial blood group activity.


Detection of lymphocytic choriomeningitis virus antibody in murine sera by immunofluorescence. An immunofluorescence technique developed for detection of antibody in murine sera to lymphocyitc choriomeningitis virus is described.


Microbial transformations. II. Reduction of androstene-5-3beta-OL-17-one by rhodotorula strains.


The influence of the autonomic nervous system on phagocytosis. VII. Changes caused by chronic administration of cobefrin.


The influence of the autonomic nervous system on phagocytosis. 8. Changes caused by chronic administration of carbaminocholine.


Studies on the transplantation barrier in the light of proteolysis inhibitors.


Effect of prolonged intravenous infusion of dextran on gastric secretion of rats bearing permanent gastric fistulas.


The sites of action of human and swine pepsins on the B chain of oxidized insulin.


Application of electron diffraction to biological electron microscopy. Three methods by which electron diffraction may be applied to problems in electron microscopy are discussed from a fundamental point of view, and experimental applications with biological specimens are demonstrated for each case. It is shown that wide-angle electron diffraction provides valuable information for evaluating specimen damage that can occur either during specimen preparation or while in the electron beam. Dark-field electron microscopy can be used both to enhance the image contrast and to provide highly restricted and therefore highly specific information about the object. Low-angle electron diffraction provides quantitative information about the object structure in the range from 20 A to approximately 1000 A. Lowangle electron diffraction also demonstrates the important role of Fourier contrast with biological specimens, which are usually characterized by structural features with dimensions of 20 A or larger.


Macromolecular finestructure by dark field electron microscopy. The potential of dark field electron microscopy for examining details of unstained unshadowed macromolecules has been studied. Images produced by scattered electrons show sufficient contrast and resolution to reveal the helical nature of short sections of DNA or the cleft containing the active site in ribonuclease. Spreads of transfer RNA were observed to contain many trifoliate structures.


The incidence, epidemiology and control of salmonellosis in domestic animals and poultry in South Africa.


The induction of malignant lymphomas and other tumors by 7,12-dimethylbenz(a)anthracene in the Syrian golden hamster.


Response to highly purified L-asparaginase during therapy of acute leukemia.


Attempt to utilize 1 per centphenol for bacteriological sterilization of calf lymph smallpox vaccine.


The character of the forces binding erythrocytes and bacterial sensitins. (1st communication). I. Significance of electrostatic, hydrogen and hydrophobic interactions in the firmly bound complex erythrocyte-sensitin.


Small intestinal mucosal cell proliferation and bacterial flora in the conventionalization of the germfree mouse. The relationship between intestinal colonization and the small bowel mucosal cellular proliferation rate during conventionalization of the germfree mouse was examined. 16 mice were maintained under standard germfree conditions, and 54 others were conventionalized. Migration of the small bowel epithelial cells was followed by radioautography with administration of tritiated thymidine. Colonization was followed by qualitative and quantitative bacteriological fecal analyses. The percentages of the villi labeled (as determined by cell count) 24, 48, and 72 hr following thymidine administration showed immediate progression in the conventionalized animals from the germfree villus migration time (4 days) toward the conventional villus migration time (2 days). The epithelial migration rate of animals conventionalized for 8 days was comparable to that of conventional animals. After conventionalization, aerobic and anaerobic organisms undergo a period of extensive multiplication; however, 72 hr later the number of these microorganisms cultured in the stool decrease and are similar to those recovered from normal animals. Coliforms and streptococci are recovered in large numbers only in the first days after conventionalization, while the Bacteroides are first recovered in significant numbers on the fifth day of conventionalization. Except for smaller numbers of Bacteroides, the bacterial populations in the stools of the conventionalized animals are qualitatively and quantitatively similar by the eighth day of conventionalization to those of true conventional mice. Adaptive balance between cell proliferation and sloughing, and thus migration rate, begins immediately after conventionalization of germfree animals as bacterial populations establish themselves throughout the gastrointestinal tract, and results in a doubling of the mucosal cell turnover after 8 days. At this time both the small intestinal epithelial cell migration rate and the intestinal microflora are similar to those of conventional animals.


Frequency of occurrence of E. coli strains capable of transferring multiple resistance in infection of the urinary tract, and properties of some of their R factors.


Development of veterinary science in Sweden from 1863 to 1963,.


The occurrence of suppressors in caffeine-resistant mutants from E. coli K12.


Studies on the structure and ultrastructure of the intact and "methallibure" -treated meso-adenohypophysis of the viviparous teleost Cymatogaster aggregata Gibbons.


Chromosome aberrations induced in human lymphocytes by x-irradiation in vitro: the effect of culture techniques and blood donors on aberration yield.


Microtubules in the spermatid of the rabbit.


The fine structure of the compound eye of a damsel-fly.


On the identity of two bacterial mutator genes: effects of antimutagens.


The testicular interstitial tissue of the amphibian Physalaemus fuscumaculatus.


Influence of flow pattern on the distribution of respiratory air during intermittent positive-pressure ventilation.


The effect of local anaesthetics on the central circulation and respiration in man and dog.


Indolealkylamines and behavior.

Indolealkylamines and behavior.


Platelet 5-hydroxytryptamine as a model in pharmacology.


Roderick Angus Gordon, C.D., B.SC., M.D., D.A., F.R.C.P.(C), F.F.A.R.C.S., F.A.C.A.


Determination of hydroxyindoles in biological materials.


John Gillies, C.V.O., M.C., M.B., CH.B.

John Gillies, C.V.O., M.C., M.B., CH.B.


Dr. Cecil Darling Kean.

Dr. Cecil Darling Kean.


Clinicolaboratory experience with hetacillin.


Recent antiviral chemotherapy publications.


Mechanism of action of biphenyl-ketoaldehyde derivatives.


Diarrheal diseases.

Diarrheal diseases.


Inheritance of a chromosome with lateral translocation (A2). Studied by anoptral-contrast method.


Accumulation of cardiac glycosides.

Accumulation of cardiac glycosides.


Chemotherapy of acute leukemia in childhood.


Hemodialysis and homotransplantation in advanced renal failure.


A method for the fine structural localization of monoamine oxidase.


False-positive reactions in ribonucleic acid films exposed to sections of brain tissue for demonstrating ribonuclease activity.


Histochemical titles from current literature.


Rapid demonstration of adrenergic nerves in tissue sections.


The histochemical demonstration of protease activity in rat and guinea pig adipose tissues.


Drs. Yater and Kyle honored by the College of Physicians.


Anton Pusinelli, M.D. (1815-1878). Janissary to a genius.


Peroxidase-associated binding of estradiol by the rat uterus.


The use of beta-adrenergic receptor blocking drugs in dysrhythmias.


Toxicity and hazards to man, domestic animals, and wildlife some commonly used auxin herbicides.


Ethacrynic acid and furosemide: renal pharmacology and clinical use.


Significance of organochlorine insecticide residues in fresh plants as possible contaminants of milk and beef products.


Some characteristics of geriatric patients.


Medicare administrative alternatives, prospects and trends.


The "Golden Eagle" pharmacy of the fortress of Buda.


Treatment of generalized lymphogranulomatosis and reticuloendothelioma with Vinblastin.


Pharmaceutical laboratory glassware in the 18th century.


Harvey Cushing 1869-1939.

Harvey Cushing 1869-1939.


Choh Hao Li.

Choh Hao Li.


Immunosuppressive therapy of proliferative glomerulonephritis in children.


Alson E. Braley, M.D.

Alson E. Braley, M.D.


A larger Iowa implant.

A larger Iowa implant.


Congenital ocular syphilis.

Congenital ocular syphilis.


Bacterial pseudomycosis of the orbit.

Bacterial pseudomycosis of the orbit.


Relationship of reticuloendothelial functional activity to endotoxin lethality.


Sympathetic and hemodynamic effects on capacitance vessels in dog skeletal muscle.


The detection of bacteria and viruses in liquids.


Frederick Thayer Hill, M. D. 1899-1969.

Frederick Thayer Hill, M. D. 1899-1969.


Lithium-carbonate treatment in depression and mania. A longitudinal double-blind study.


Adaptation of evoked auditory potentials: a midbrain through frontal lobe map in the unanesthetized cat.


Monosynaptic pyramidal activation of pontine nuclei cells projecting to the cerebellum.


Diseases of function and stability of haemoglobin.


Measurement of cortisol-stimulated gluconeogenesis in the rat.


Effect of biogenic amines, FSH-releasing factor (FRF) and other substances on the release of FSH by pituitaries incubated in vitro.


Deletions in limited homology recombination in Escherichia coli.


Locus for radiation resistance in Escherichia coli strain B-r.


Mutagens which cause deletions in Escherichia coli.


Studies of the development and subsequent reduction of swelling of mammalian cerebral cortex under isosmotic conditions in vitro.


Toward a neurophysiology of pain.

Toward a neurophysiology of pain.


Studies on E. coli strain isolated from coligranuloma in fowl.


An epizootic of Serratia marcescens (Enterobacteriaceae) in Periplaneta fuliginosa (Blattaria) and a suggested method for control.


Cancer of the urogenital tract: prostatic cancer. Introduction.


Experimental studies related to autoimmunity in myasthenia gravis.


Chemical tests in the diagnosis of prostatic carcinoma.


Pathologic differentiation and prognosis of prostatic carcinoma.


Kaspar Friedrich Wolff (1733-1794).

Kaspar Friedrich Wolff (1733-1794).


Environmental pollution with resistant microbes.


Effect of antibiotic therapy in acute salmonellosis on the fecal excretion of salmonellae.


Hyperoxygenation effect on cognitive functioning in the aged.


Egor Scheffer--Russia's Hawaiian interloper.


Recanalization of the inferior vena cava after ligation.


Change in the base composition of messenger RNA of Escherichia coli by ultraviolet irradiation and its recovery.