Comparison of materials used for cleaning equipment in retail food premises, and of two methods for the enumeration of bacteria on cleaned equipment and work surfaces. There is no official scheme for testing disinfectants and detergent/disinfectants for use in the retail food trade and few recommended procedures have been given for the cleaning of equipment with these agents. Therefore, field trials were carried out in a large self-service store. Comparisons were made of the various cleaning efficiencies, as determined by bacterial plate counts, of detergent and disinfectant solutions and machine cleaning oils applied with either clean cloths or disposable paper towels to items of equipment. The most satisfactory results were always obtained when anionic detergent (0.75% w/v) and hypochlorite (200 p.p.m. available chlorine) solutions were applied in a ;two-step' procedure.Tests were made to compare the calcium alginate swab-rinse and the agar sausage (Agaroid) techniques for the enumeration of bacteria on stainless steel, plastic, formica and wooden surfaces before and after a cleaning process. Although recovery rates were always greater by the swab-rinse technique, the agar sausage technique was considered to be a useful routine control method for surface sampling.


Comparative toxicity of various ozonized olefins to bacteria suspended in air. Air containing olefin vapour was treated with known amounts of ozone simulating natural concentrations. The bactericidal effect of the mixture was tested using microthreads sprayed with washed cultures of Escherichia coli var. communis or Micrococcus albus, aerosol strain. With 20 different olefins a wide range of activity was found, those in which the double bond formed part of a ring being the most bactericidal; petrol vapour was about as active as the average open-chain olefin. The two organisms behaved similarly at the experimental relative humidity of 80%. The estimated amount of bactericidal substance present was only about one hundredth of that required to give the same kill with a ;conventional' air disinfectant; a simple physical explanation is proposed for this enhanced effect.


The use of cough-nasal swabs in the rapid diagnosis of respiratory syncytial virus infection by the fluorescent antibody technique. Thirty-five consecutive infants admitted into hospital in Newcastle upon Tyne with acute respiratory disease had cough/nasal swabs and nasopharyngeal secretions taken. Both types of specimens were examined by the fluorescent antibody technique for respiratory syncytial virus; isolation techniques were also used. Twenty-eight specimens of nasopharyngeal secretion were positive, as were 26 of the corresponding cough/nasal swab preparations. Respiratory syncytial virus was isolated from all but one.Sixteen consecutive children who were only suitable for examination by cough/nasal swab preparations were also investigated by isolation and fluorescent antibody techniques for respiratory syncytial virus. Respiratory syncytial virus was isolated from eight, seven of whom were positive by the fluorescent antibody technique. The use of cough/nasal swab preparations stained by the fluorescent antibody technique, although not as efficient as nasopharyngeal secretions, may have a place in the rapid diagnosis of respiratory virus infection in older children and children in general practice. The importance of rapid diagnosis for respiratory virus infection in relationship to antiviral therapy was also discussed.


The use of gamma radiation for the elimination of Salmonella from frozen meat. The use of a gamma radiation process for the elimination of Salmonella from frozen meat is considered with particular reference to the treatment of boned-out horsemeat and kangaroo meat imported into the UK and intended for use as pet meat.Examination of dose/survival curves produced for several serotypes of Salmonella in frozen meat shows that a radiation dose of 0.6 Mrad. will reduce a population by at least a factor of 10(5). The influence on the radiation resistance of salmonellas of such factors as preirradiation growth in the meat and temperature during irradiation have been examined and considered. It is also demonstrated with both preinoculated and naturally contaminated meat that postirradiation storage in the frozen state does not lead to the revival of irradiated salmonellas.The properties of Salmonella survivors deliberately produced in meat using conditions of irradiation designed to simulate a commercial process are studied after six recycling treatments through the process. There were no important changes in characteristics normally used for identification of Salmonella but radiation resistance was lowered. Survivors grown in situ in meat after irradiation showed an abnormally long lag phase, and removal of competitive microflora in meat by the radiation treatment can influence the growth of salmonellas.


Aesculapius comes to the St. Joseph Valley.


Isolation of bacteriophage T4 mutants defective in the ability to degrade host deoxyribonucleic acid. A method was devised for identifying nonlethal mutants of T4 bacteriophage which lack the capacity to induce degradation of the deoxyribonucleic acid (DNA) of their host, Escherichia coli. If a culture is infected in a medium containing hydroxyurea (HU), a compound that blocks de novo deoxyribonucleotide biosynthesis by interacting with ribonucleotide reductase, mutant phage that cannot establish the alternate pathway of deoxyribonucleotide production from bacterial DNA will fail to produce progeny. The progeny of 100 phages that survived heavy mutagenesis with hydroxylamine were tested for their ability to multiply in the presence of HU. Four of the cultures lacked this capacity. Cells infected with one of these mutants, designated T4nd28, accumulated double-stranded fragments of host DNA with a molecular weight of approximately 2 x 10(8) daltons. This mutant failed to induce T4 endonuclease II, an enzyme known to produce single-strand breaks in double-stranded cytosine-containing DNA. The properties of nd28 give strong support to an earlier suggestion that T4 endonuclease II participates in host DNA degradation. The nd28 mutation mapped between T4 genes 32 and 63 and was very close to the latter gene. It is, thus, in the region of the T4 map that is occupied by genes for a number of other enzymes, including deoxycytidylate deaminase, thymidylate synthetase, dihydrofolate reductase, and ribonucleotide reductase, that are nonessential to phage production in rich media.


Effect of the "ribonucleic acid control" locus in Escherichia coli on T4 bacteriophage-specific ribonucleic acid synthesis. Amino acid control of ribonucleic acid (RNA) synthesis in bacteria is known to be governed genetically by the rel locus. We investigated whether the rel gene of the host would also exert its effect on the regulation of phage-specific RNA synthesis in T4 phage-infected Escherichia coli cells. Since T-even phage infection completely shuts off host macromolecular synthesis, phage RNA synthesis could be followed specifically by the cumulative incorporation of radioactivity from labeled precursors into RNA of infected cells. Labeled uracil was shown to accumulate in phage-specific RNA for 30 to 35 min after infection, a phenomenon which probably reflects an expansion of the labile phage-RNA pool. Amino acid starvation was effected by the use of auxotrophic bacterial strains or thienylalanine. The latter substance is an amino acid analogue which induces a chemical auxotrophy by inhibiting the biosynthesis of phenylalanine, tyrosine, and tryptophan. Phage RNA synthesis was strictly dependent on the presence of amino acids, whereas phage deoxyribonucleic acid synthesis was not. By the use of several pairs of bacterial strains which were isogenic except for the rel gene, it was demonstrated that amino acid dependence was related to the allelic state of this gene. If the rel gene was mutated, amino acid starvation did not restrict phage RNA synthesis.


Freshwater macroinvertebrates.

Freshwater macroinvertebrates.


Eutrophication.

Eutrophication.


Bacteriophage tail components. I. Pteroyl polyglutamates in T-even bacteriophages. A pteroylpolyglutamate has been found to be a constituent of all Escherichia coli T-even bacteriophages and has been characterized with regard to its oxidation state, molecular weight, origin, and location on the phage particle. The phage compound has been shown to be a dihydropteroyl penta- or hexaglutamate on the basis of its chemical and physical properties. Analyses of extracts of uninfected and T2L-infected E. coli have indicated that the phage dihydropteroyl polyglutamate was present only in infected cells. Its synthesis was sensitive to the addition of chloramphenicol before infection, and the compound appeared to be specifically induced by phage infection. Analyses of isolated phage ghosts and tail substructures have shown that each phage particle contains between two and six phage-specific pteroyl derivatives and that the juncture of the phage tail plate with the tail tube is the most likely site of binding of the phage-induced pteroyl compound.


Thermal pollution--biological effects.

Thermal pollution--biological effects.


Microbiology. Waterborne outbreaks.

Microbiology. Waterborne outbreaks.


Oxygen sag and stream self-purification.


Effects on groundwater. Wastewater reclamation.


Effects on surface waters.

Effects on surface waters.


Marine and estuarine pollution.

Marine and estuarine pollution.


Effects on marine biology.

Effects on marine biology.


Systems analysis.

Systems analysis.


Economics.

Economics.


Law.

Law.


Industrial wastes.

Industrial wastes.


Canning.

Canning.


Agricultural (livestock) wastes.

Agricultural (livestock) wastes.


Coal and coal mine drainage.

Coal and coal mine drainage.


Solid waste composting.

Solid waste composting.


Tannery wastes.

Tannery wastes.


Textile waste.

Textile waste.


Steel industry wastes.

Steel industry wastes.


Petroleum processing wastes.

Petroleum processing wastes.


Plating and cyanide wastes.

Plating and cyanide wastes.


Deep-well injection.

Deep-well injection.


Industrial wastes--radioactive.

Industrial wastes--radioactive.


Wastewater treatment. Biological filters.


Organics.

Organics.


Lagoons and oxidation ponds.

Lagoons and oxidation ponds.


Detergents.

Detergents.


Anaerobic processes. Microbiology and mechanisms.


Sludge treatment, disposal, and utilization.


Disinfection.

Disinfection.


Water reclamation and reuse.

Water reclamation and reuse.


Wastewater and storm flow treatment.

Wastewater and storm flow treatment.


Physical and chemical methods. Water reclamation.


Water pollution. Effects of pollution on fish life.


Of secrets and secretaries.

Of secrets and secretaries.


Renal transplantation for childhood cystinosis.


The quality of life.

The quality of life.


Transfer factor and cellular immune deficiency disease.


Portrait of a leader: Annie Warburton Goodrich.


Diploma programs in nursing accredited by the National League for Nursing. School year: September 16, 1970-September 15, 1971.


Cardiology in the 1970's.

Cardiology in the 1970's.


Effect of gamma radiation on Serratia marcescens. Studies on the radiosensitivity of prodigiosin production.


Tests of pancreatic function.

Tests of pancreatic function.


The effect of 1-hyoscyamine on pentagastrin-induced secretion of acid and pepsin in man.


Subcellular structure of the synovial membrane in rabbits under experimental conditions.


Mesenchymal tumours of the stomach.

Mesenchymal tumours of the stomach.


47Ca studies in adult coeliac disease and other gastrointestinal conditions with particular reference to osteomalacia.


Whole body counting of vitamin B12 58Co absorption supplemented by profile scanning.


Retention of oral 47Ca in patients with intestinal malabsorption: regional enteritis and pancreatic insufficiency.


Fitness of an Escherichia coli mutator gene. Competition experiments between Escherichia coli mutT1 and mut(+) populations show that the mutator gene confers selective advantage on the strain that carries it. The observed increase in fitness varies, with an average increase in mutator growth rate of 1.4 percent when mutator and wild-type strains are grown together in chemostats.


Circadian rhythms in human heart homograft. The electrocardiogram and cardiotachogram of a patient with a human heart transplant has been recorded for 72 hours. Within the donor P-QRS-T complex, one can identify the P waves emanating from residual sinoatrial heart tissue of the recipient. The recipient P waves are independent of the donor complexes. A clear circadian rhythm (23.4 hours) in heart rate is maintained for both donor and recipient tissue, the donor complexes preceding by a phase shift of 135 minutes the complexes of the recipient heart tissue. Both tissues display clear morning and evening minimum and maximum rates paralleling activity and lighting cycles.


Leg ulcers in sickle-cell anaemia.

Leg ulcers in sickle-cell anaemia.


Dr. F. Gregory Connell--first president of the Wisconsin Surgical Society.


L-asparaginase; a new type of anticancer drug.


Prostaglandins in reproductive physiology. This review of prostaglandins (PGs) in reproductive physiology discusses nomenclature, biosynthesis, separation, and analysis, and then focuses on studies with PGs from various sources, including human semen.  The structural formulas of human seminal PGs are reproduced in the text.  The relationship between PGs and uterine function, fallopian tube function (and possible sperm transport), and ovarian function is reviewed.  Recent studies which suggest possible roles for PGs in luteolysis, ovum transport, and implantation suggest that PGs have potential as antifertility agents.  An addendum is included which summarizes PG pharmacological data from various sources.


Bloodletting and bandaging. Barber surgery as an occupation.


Warren Fales Draper, MD. 1883-1970.

Warren Fales Draper, MD. 1883-1970.


Biological activities of endotoxin from Bacteroides melaninogenicus.


Cardiac output in newborn infants.

Cardiac output in newborn infants.


Certain causes of neonatal death. I. Hyaline membranes.


Intravenous diazepam in conservative dentistry. A clinical trial.


Complete dentures for patients exhibiting mandibular prognathism.


Infiltration histological specimens with paraffin wax under vacuum. Basic factors and a new approach.


Treatment of denture stomatitis with polynoxylin. A double-blind trial.


Effects of the American Revolution.

Effects of the American Revolution.


Development of corneal transplant and its future.


Survey shows administrators dissatisfied with Medicare.


What patients think of Medicare.

What patients think of Medicare.


Medicare changes attitude of industry toward hospitals.


Charles Murchison (1830-1879).

Charles Murchison (1830-1879).


Propoxyphene hydrochloride. A critical review.


Anticoagulant therapy in coronary ischemic disease.


Operation for ectropion associated with anophthalmos.


Inactivation of Salmonella in poultry with gamma radiation.


Effect of moisture on Salmonella populations in animal feeds.


Effect of moisture and temperature on ability of Salmonellae to infect shell eggs.


Serum hepatitis--a historical perspective and current progress.


Obstetric anesthesia: the first ten years.


Hydroxyurea. A new treatment for psoriasis.


Simplified laboratory technique for diagnosis of chancroid.


Bullous pemphigoid in an 11-year-old boy.


Treatment of infected cyst of the back in ancient China.


Drug reactions to the sulfones.

Drug reactions to the sulfones.


Heparin therapy and its laboratory control.


The relationship between age and the failure rate of bridge prostheses.


A decrease in anoxic sensitivity, and resultant increase in oxygen enhancement ratio, with decrease in energy of fast electrons.


Vagotomy for gastric ulcer.

Vagotomy for gastric ulcer.


Radiosensitization of Shigella flexneri and Escherichia coli by methyl hydrazine, indane trione and acriflavine.


Measurement of plasma volume by means of 59Fe-labelled dextran and Evans blue compared. The apparent volumes of distribution of Evans blue and (59)Fe-dextran were determined in 18 studies.(59)Fe-dextran volume was 5% lower than Evans blue volume, a highly significant difference. The rate of loss of (59)Fe dextran from the circulation was significantly less than that of Evans blue.


Comparative study of the cardiovascular system.


Studies of potassium depletion using direct measurements of total-body potassium.


The pepsins of patients with peptic ulcer.


A comparison of the chromatic and achromatic figure drawings of adult psychiatric patients.


Projective drawings in a cerebellar disorder due to chicken pox encephalitis.


The first cleavage of the amphibian egg. An electron microscope study of the onset of cytokinesis in the egg of Ambystoma mexicanum.


The United States Pharmacopeia. Its value to the professions.


Humanism and the medical past.

Humanism and the medical past.


Henry Pickering Bowditch (1840-1911). Harvard physiologist.


Human renal transplantation: current status and prognosis.


Partial orthotopic liver transplantation.


Politics, universities and teaching hospitals.


The use of etiocholanolone for the measurement of marrow granulocyte reserves.


An evaluation of current trends in the management of breast abscesses.


A survey for enteropathogenic bacteria in a babies' home, with special reference to the significance of enteropathogenic Escherichia coli.


William Joseph Rawlings.

William Joseph Rawlings.


To the 70th anniversary of Professor Václav Sváb.


To the 60th anniversary of Prof. Vladimír Stasek.


Our experiences with the treatment of malignant tumours of the tongue in the years 1950-1963.


Histocompatibility testing in renal transplantation.


Balantidium coli infection in a Vietnam returnee.


The growth-duplication cycle. X. Appearance of phage binding sites during the cell cycle of Escherichia coli. ANL-7635.


Immunofluorescent localization of ornithine aminotransferase in rat liver. ANL-7635.


The growth-duplication cycle. XI. Growth of nondividing cells deprived of thymine. ANL-7635.


Mutation in continuous cultures. I. Repair of UV-induced lethal and mutational lesions. ANL-7635.


Mutation in continuous cultures. II. Spermine and cadaverine as antimutagens. ANL-7635.


Mutation in continuous cultures. 3. Nuclear selection. ANL-7635.


Changes in the mean cell volume of Escherichia coli after bacteriophage infection. ANL-7635.


Lethal and genetic effects of radioisotope decay in bacteriophages and bacteria. ANL-7635.


Effects of cell size and DNA synthesis on radiation sensitivity of Escherichia coli. ANL-7635.


Microvasculature and loose connective tissue of the chick mesentery. Freeze-etch observations. ANL-7635.


Mutagenesis by ultraviolet and visible light in continuous cultures. ANL-7635.


Growth and mutagenesis in the nephelostat. ANL-7635.


Effects of ultraviolet and visible light on a multiple repair-deficient strain of Escherichia coli. ANL-7635.


Lethal effects of long wavelenght ultraviolet and visible light on cells. ANL-7635.


The course and central termination of first order neurons supplying vestibular endorgans in the cat.


Reversible psychosis and dementia in myxedema.


Diabetogenesis.

Diabetogenesis.


Subnormal secretion of insulin in mild diabetes mellitus.


Prevention of bedrest induced orthostatism by 9-alpha-fluorohydrocortisone.


A comparison of shortening and Z line degradation in post-mortem bovine, porcine, and rabbit muscle.


Characterization of the Haemophilus-like organism of infectious thromboembolic meningoencephalitis of cattle.


The John Barnwell Lecture. The chemotherapy of bacterial respiratory infections.


Serologic, pathologic, and immunologic features of experimentally induced leptospiral nephritis in dogs.


Antifertility agents.

Antifertility agents. The emphasis in this review is upon agents influencing postcoital events.  Drugs discussed exert their effects upon the central nervous system, peripheral hormonal organs, fertilization, tubal transport, blastocyst implantation, and the zygote.  The relationships between estrogenic, antiestrogenic, and antifertility activities of the drugs are discussed.  The peculiarities of the nonsteroidal compounds may be due to the period of time they occupy receptors in the uterus or other target organs.  Special attention is given to stilbene and bibenzyl derivatives; basic ether derivatives of DMS and related compounds; and U-11,100A, U-11,555A, and similar compounds.


Persistent pesticides.

Persistent pesticides.


Scope and limitations of therapy with plasma substitutes: differential indication for substitutes, blood preparations and electrolyte solutions.


Review article: urography.

Review article: urography.


Effect of long term anticholinergic therapy on gastric acid secretion, with observations on the serial measurement of peak histalog response.


Clinical trial of milkweed (Asclepius curussavica) in the treatment of warts.


The introduction of chloral hydrate into medical practice.


The volume of the intracranial contents.


A clinical trial with a new topical antimycotic agent 4-chloro-2-hydroxybenzoic acid-n-butylmide i.e. buclosamide.


Royce Paddock (1889-1969).

Royce Paddock (1889-1969).


Primary keratomycosis.

Primary keratomycosis.


Continuous in vitro culture system for ruminant research. I. Design.


Yellow fever, cholera, and the beginnings of medical cartography.


Evidence for transformation of spleen cells one day after infection of mice with friend leukemia virus. Proliferation and erythroid differentiation of transplanted DBA/2 marrow cells and Friend virus-induced leukemic cells were assessed in syngeneic, allogeneic (H-2 compatible), and (BALB/c x DBA/2)F(1) hybrid mice (CDF(1)). Measurements were made 5 days after transplantation of donor cells into nonirradiated or X-irradiated mice by the spleen colony or the (125)IUdR-(59)Fe uptake methods. Growth of DBA/2J (Jackson subline) marrow grafts was poor in irradiated CDF(1)J hybrids as compared with growth in syngeneic and allogeneic hosts. The DBA/2J transplants proliferated, however, without impairment in irradiated CDF(1) hybrids which were the progeny of DBA/2 male parents of other sublines, e.g. DBA/2Ha, DBA/2Cr, and DBA/2Cum. In contrast, tissue-cultured Friend leukemic cells of DBA/2J origin grew deficiently in all CDF(1) hybrids tested, regardless of irradiation and of the DBA/2 parent's subline. The growth pattern of transplanted DBA/2J cells was a manifestation of hybrid resistance. The results with DBA/2J and other DBA/2 subline grafts suggested that hybrid histocompatibility alleles were expressed to a greater extent in leukemic than in normal marrow cells, for the former were consistently recognized as "nonself" by CDF(1) mice, but not the latter cells. The property of deficient growth in irradiated CDF(1)Ha hybrids was acquired by DBA/2J hemopoietic cells within 6 hr from infection in vivo with Friend leukemia virus, and persisted during the following 8 days. It was ascribed to enhanced expression of hybrid histocompatibility gene(s) (Hh) induced by the virus. Autonomous growth potential of hemopoietic cells, manifested by proliferation in nonirradiated recipients, was first detected 24 hr from infection, and likewise persisted at the later intervals. At the same time, the infected cells grew deficiently also in nonirradiated CDF(1)Ha mice. The two irreversible cellular changes were regarded as the earliest signals of virus-induced transformation.


Diffuse familial nephropathy: a clinicopathological study.


Report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry.


Breathholding spells in children. Differentiation from epileptic attacks.


Human renal transplants. 3. Immunopathologic studies.


Oral hygiene performance of elementary school children following dental health education.


Tertius Lydgate in Middlemarch and Thomas Clifford Allbutt.


The present status of corneal transplantation.


Cellular effects from microbeam irradiation of Basidiobolus ranarum with a laser.


Zinc deficiency in burned children.

Zinc deficiency in burned children.


Composite lower jaw reconstruction.

Composite lower jaw reconstruction.


Secondary coverage of pretibial skin defects. Report of four representative cases.


Speech articulation and tongue movements in bone-grafted cleft palate patients.


Two new methods of rhinoplasty.

Two new methods of rhinoplasty.


Commentary: The first free bone graft to the nose.


Regarding leg ulcers and hyperbaric oxygen.


Skin homografts in epidermolysis bullosa dystrophica. Case report.


The changing concept of organism in microbiology.


Passive ion permeability of the erythrocyte membrane.


Medical schools: portents of National Health Insurance.


Evaluation of the patient with hemobilia.


Assessment of the duodenal ulcer patient as a surgical candidate.


A critical assessment of culdoscopy.

A critical assessment of culdoscopy.


Thymus-bone marrow interaction in transplantation immunity.


Antilymphocyte serum and lymphatic system. I. The effect of regional administration on the survival of skin allografts.


Post-pneumoencephalography headache. A study of incidence and an attempt at therapy.


Bronchial lavage in status asthmaticus. A long term review after treatment.


Partial dentures. 3. Components.

Partial dentures. 3. Components.


Partial dentures. 7. Maintenance of the appliances.


Impression technique for maxillary fibrous ridge.


The masticatory performance, dental state, and dietary intake of a group of elderly army pensioners.


Incidence of congenital malformations in the regions of England and Wales.


Relevance of salt, water, and renin to hypertension in chronic renal failure. Blood pressure control was examined in 75 patients with end-stage renal failure treated by regular twice-weekly haemodialysis. Dietary sodium was restricted and extracellular fluid was removed by ultrafiltration until blood pressure was normal or signs of salt depletion were observed. Failure of these measures constituted an indication for nephrectomy. Of the 75 patients, 18 were never hypertensive, 46 had hypertension which could be corrected by salt and water depletion, and 11 had persistent hypertension which could not be controlled in this way. Nine of these 11 patients underwent bilateral nephrectomy; in each of the seven in whom the post operative result could be evaluated the blood pressure returned rapidly to normal.Plasma renin activity, measured in 34 subjects, was raised above normal in six out of nine patients whose blood pressure could not be controlled by salt and water depletion and in one of the 11 patients whose blood pressure could be so controlled, but was within the normal range in all nine normotensive patients. The mean level of plasma renin activity in the first group was significantly higher than that of each of the other two groups.There was a significant correlation between hypertension during dialysis and after transplantation, suggesting that, in addition to renin, there is a non-renal factor which predisposes certain patients to hypertension in the presence of salt and water excess.


Respiratory syncytial virus infection of the newborn. In an outbreak of respiratory syncytial (R.S.) virus infection in a maternity hospital the respiratory illness was of a mild nature and the virus was not found in infants without respiratory symptoms. This confirms the suggestion that R.S. virus can infect infants at a very early age. Rapid diagnosis was achieved by applying the direct fluorescent antibody technique to cells in nasal secretions. This proved to be more sensitive than culture techniques where there was delay between the onset of respiratory symptoms and submission of specimens to the laboratory.


Ergotamine tartrate in migraine.

Ergotamine tartrate in migraine.


Folate and vitamin B12 in epilepsy.

Folate and vitamin B12 in epilepsy.


House-dust asthma.

House-dust asthma.


Treatment of the nephrotic syndrome.

Treatment of the nephrotic syndrome.


Sacrococcygeal teratoma of the fetus complicating pregnancy.


Synthesis and preliminary biological investigation of several N-alkyl aspartic acid derivatives.


Histone-induced macrophage disappearance reaction in normal guinea pigs.


Prediction of carcass fat, water and lean body mass from Lee's "nutritive ratio" in rats with hypothalamic obesity.


Activity of contractile vacuole in the parasitic ciliate, Balantidium coli.


Radio-sensitization with iodine compounds. II. Studies on mutant strains of Escherichia coli K12 resistant to radiation-induced toxic products from iodoacetic acid, potassium iodide or potassium iodate.


Persistence of pre-irradiation immunity to Hymenolepis nana in syngeneic chimaeras: influence of radiation dose and time of marrow injection.


In vitro degradation of irradiated deoxyribonucleic acid by crude extracts from Salmonella typhimurium and Escherichia coli B-r.


Liver fixation for electron microscopy by means of transparenchymal perfusion with glutaraldehyde.


The distribution of water-soluble blood group A antigen in the human large intestine: a mosaic pattern.


New light on the discovery of penicillin.


Dosage schedules in general practice.

Dosage schedules in general practice.


Towards the conquest of pain: Sir James Y. Simpson, Bt, M.D. (1811-1870).


Thoughts at random. A running commentary.


Aflatoxin susceptibility in various breeds of poultry.


Epstein-Barr virus-induced viral and soluble complement-fixing antigens in Burkitt lymphoma cell cultures.


Immunofluorescence of adenovirus type 7 T-antigen(s) and virion antigens in infected KB cells.


Differences in antibody responses of mouse strains to enterobacterial common antigen.


Peripelvic extravasation in chronic ureteral obstruction by reticulum-cell sarcoma.


In memoriam Anna Hamann, M.D. 1894-1969.


In memoriam Arthur Chandler Jr., M.D. Dec. 23, 1928--Dec. 4, 1969.


The inadequate chin.

The inadequate chin.


Summary of recent abstracts. 3. Malaria.


Influence of serotonin (5-hydroxytryptamine) on the cellular exudate in skin windows.


Bertram Shirley Kraus 1913-1970. A biographical sketch.


Hypercalcemia after renal transplantation.


Health is a community affair. A bookshelf compiled from the reports of the National Task Forces project.


Downstream aortography.

Downstream aortography.


Eugene Francis Van Epps, M.D., 1912-1970.


A short history of quarantine (Victor C. Vaughan).


Dental conditions in a group of mediaeval English children.


The failure of retainers in bridge prostheses. An analysis of 2,000 retainers.


Partial dentures. 4. Surveying.

Partial dentures. 4. Surveying.


Partial dentures. 5. Design.

Partial dentures. 5. Design.


Partial dentures. 6. Free-end saddle dentures.


The gold myth.

The gold myth.


Editorial.

Editorial.


Respiratory distress syndrome.

Respiratory distress syndrome.


Air embolism during neurosurgery. A case report.


Arterial oxygenation and physiological deadspace during anaesthesia. Effects of ventilation with a pressure preset ventilator.


The treatment of erythrasma in a hospital for the mentally subnormal.


The history of dermatology in Dublin.

The history of dermatology in Dublin.


The external treatment of psoriasis. A controlled investigation of the effects of dithranol.


Melanokinetics and the biological significance of melanin.


The changing epidemiology of subphrenic abscess and its clinical and radiological consequences.


A defect of glucose utilization in adipose tissue of adult diabetics and in some conditions which may predispose to diabetes.


The morphological aspects of shunt-path in the epithelium of the frog skin (R. temporaria).


A kinetic model of granulocytopoiesis.

A kinetic model of granulocytopoiesis.


Proper use of biological indicators in sterilization.


Spermatogonial and meiotic chromosomes of the Armenian hamster, Cricetulus migratorius.


Pharmacy in poverty areas--a literature search.


VA transfers CS to supply service, returns most nurses to patient care.


Studies on the mode of action of progesterone on chicken oviduct epithelium. I. Morphological changes associated with early differentiation of the tissue.


Quantitative methods in histology.

Quantitative methods in histology.


Dechlorination of DDT by membranes isolated from Escherichia coli.


A simplified technique for the identification of coliform bacilli.


An automated microbial colony counter.

An automated microbial colony counter.


A short scheme for the rapid identification of gram-negative bacilli in urine.


Microbiological control for sterile pharmaceutical products.


Seronegative dementia paralytica: report of a case. Dementia paralytica may present diagnostic difficulties when routine serological test using a non-treponemal antigen is non-reactive. We present an illustrative demented patient who initially had negative VDRL test both in his serum and cerebrospinal fluid. However, the brain biopsy specimen showed active meningoencephalitis. By special staining technique, a spiral organism was found in the brain exhibiting morphology perfectly compatible with treponema pallidum. Later in the course, the VDRL became reactive in the blood but remained non-reactive in the cerebrospinal fluid. On the basis of the experience of other workers in the field and ours with this patient, we advise the use of FTA-ABS test as a screening procedure in patients with neurological problems of possible syphilitic origin. We urge further research in this field.


John Locke, household physician and personal secretary to Ashley Cooper.


Plantation medicine.

Plantation medicine.


The ubiquitous Dr. Salmon.

The ubiquitous Dr. Salmon.


Folie communiquée-two classical cases in colonial South Carolina.


Medicine in the days of the Confederacy.


The development of organized medicine in Charleston.


A decade of progress.

A decade of progress.


A modified isotopic dilution method for measuring the serum vitamin B 12 level.


Some reflections of a surgeon.

Some reflections of a surgeon.


Roland Parks Mackay, 1900-1968.

Roland Parks Mackay, 1900-1968.


Current bibliography on allergy and applied immunology.


Continued observations on a closed hysterectomy-founded pig herd.


Poultry: principles of disease control. IV. Medication.


On the glycolytic conversion of triosephosphates in the pancreatic islets and acini of NZO mice.


Chemotherapy of chlamydial infections.

Chemotherapy of chlamydial infections.


Transport of metabolites in microorganisms.


Serial sections of lung. The use of a 70-millimeter film-strip technique for large tissue sections.


An apparatus for the continuous cultivation of sulfate-reducing bacteria and its application to geomicrobiological purposes.


Enzymic dissolution of hyphal septa in a basidiomycete.


Protective agents modifying biological effects of radiation. A selective review.


Bibliography on the physical properties of the skeletal system.


Experimental Escherichia coli pyelonephritis: formation of spheroplasts in the kidney of the untreated rat.


In memoriam Harold Williard Glattly 1902-1967.


Kidney transplantation.

Kidney transplantation.


The preservation of viable organs for transplantation.


Intrarenal distribution of blood flow in man. A new analytical method for dye-dilution curves.


Separation of donor and recipient bacteria by column chromatography. When donor and recipient strains of Escherichia coli were added to columns containing Cellex-P (a cation-exchange cellulose), more than 80% of the female cells passed through the column but only 11% or less of the male cells were eluted. However, when donor strains were blended before their addition to the column, the majority of these cells were eluted. These results indicated that the filamentous appendages termed F pili (which are removed by blending) were the structures responsible for the adherence of donor cells to the cellulose.


Operon coordination in different bacterial hosts. Coordination of gene expression in the lac operon was compared in Escherichia coli and Salmonella typhimurium as an approach to detecting possible differences in protein synthesis or membrane structure between organisms. Either a wild-type F' lac pro(AB) episome or the same episome with a polar mutation in one of the lac genes was introduced into pro(-) derivatives of the two strains of bacteria. Activity assays showed that the beta-galactosidase levels were only slightly lower in the S. typhimurium cells than in E. coli cells, whereas the transacetylase levels were significantly higher in S. typhimurium for all of the lac markers tested. Galactoside transport activities were always comparable in the two strains of bacteria; this latter result indicates that the cell envelopes of E. coli and S. typhimurium do not differ sufficiently to affect the membrane-associated lac transport system. It was found, however, that the specific transport activity is very sensitive to culture age in both bacteria, and decreases rapidly in cultures past the mid-exponential phase of growth.


Termination of deoxyribonucleic acid in Escherichia coli by 2',3'-dideoxyadenosine. 2',3'-Dideoxyadenosine was previously shown to be lethal to Escherichia coli and to inhibit deoxyribonucleic acid (DNA) synthesis irreversibly in this organism. It was also shown that triphosphate of this analogue terminates DNA chains in an in vitro system. Data presented here show that the nucleoside is relatively insensitive to E. coli adenosine deaminase and is converted intracellularly into the dideoxynucleotide, including the triphosphate. Thymine nucleotide pools were not reduced in inhibited bacteria, nor did preformed DNA break down. Some adenine was liberated from the dideoxyadenosine on incubation, and the latter was incorporated into ribonucleic acid. Nevertheless, about 4,000 molecules of the dideoxynucleoside were incorporated into DNA per cell. The dideoxynucleotide occurred in DNA chains in a terminal position, liberated selectively by venom phosphodiesterase. The possible nature of the lethal event is discussed.


Gene controlling L-glutamic acid decarboxylase synthesis in Escherichia coli K-12. Genetically related Escherichia coli K-12 strains were found to differ widely in their l-glutamic acid decarboxylase (GAD) activity. This variation is due to differences in the amount of GAD produced by the different cultures, rather than to the appearance of altered enzymes differing in catalytic activity. A regulatory gene, gadR, which controls the amount of GAD was mapped on the E. coli K-12 chromosome. A strain with a lesion in the structural gene for GAD is described.


Genetic analysis of a large-cell, radiation-resistant strain of Escherichia coli. A genetic analysis of Escherichia coli P6, a large-cell, radiation-resistant strain of E. coli, established that it originated as the result of a mutational event. The gene responsible for the complex P6 phenotype was located at 61 +/- 0.5 min on the E. coli linkage map. The close resemblance of conjugal and transductional recombinants to one or the other parent without indication of an intermediate class suggests that only a single gene may be involved.


Relationship between radiation response and the deoxyribonucleic acid replication cycle in bacteria: dependence on the excision-repair system. Prestarvation of Escherichia coli for required amino acids results in a marked enhancement in both ultraviolet light (UV) or X-ray resistance for selective strains. Preventing protein synthesis by starvation for required amino acids results in completion of the cycle of chromosomal replication then underway. We have investigated the relationship between starvation-induced resistance enhancement (SIRE) and the excision-repair (Hcr) system in several E. coli strains including E. coli B/r hcr(+) and its isogenic mutant E. coli B/r hcr(-). The following observations were made. (i) The Hcr system is the major component of SIRE in UV-irradiated strain B/r. By using the Hcr(+) strain, SIRE increases the 10% survival dose from approximately 400 ergs to approximately 1,200 ergs/mm(2). With the Hcr cells, the increase is from approximately 45 ergs to 60 ergs/mm(2). (ii) Although prestarvation leads to a moderate enhancement of resistance to X irradiation, this effect is not dependent on the Hcr system. (iii) The double mutant, E. coli B(s-1) (hcr(-)exr(-)) is completely unable to express SIRE whether studied with UV or X irradiation. It is concluded that the Hcr system is the major system responsible for SIRE in UV-treated cells, whereas Exr (resistance to X rays) may be involved to a minor extent. The Exr character appears to be required for SIRE expression in X-ray exposed cells.


Selective outgrowth of fimbriate bacteria in static liquid medium. Competitive mixed cultures were grown from inocula of a large number of bacteria of a genotypically nonfimbriate (fim(-)) strain of Salmonella typhimurium and a small number of a genotypically fimbriate (fim(+)) variant strain that formed type 1 fimbriae and had been derived from the fim(-) strain by phage transduction. The fim(+) strain differed from the fim(-) strain in fermenting l-rhamnose (rha(+)), and the viable fim(+) and fim(-) bacteria present in the cultures after different periods at 37 C were counted differentially in platings on rhamnose media. When the cultures were grown under aerobic static conditions in tubes of nutrient broth, the fim(+) bacteria rapidly outgrew the fim(-) bacteria, so that, although starting as a small minority (e.g., 1 in 10(7)), they approached or surpassed the number of the fim(-) in 48 hr. A pellicle consisting of fimbriate bacteria was formed on the surface of the broth between 6 and 24 hr, and it is thought that the advantage of access to atmospheric oxygen enjoyed by these bacteria in the pellicle enabled them to outgrow the fim(-) bacteria confined in the oxygen-depleted broth. The fim(+) bacteria did not show selective outgrowth in mixed cultures grown in broth aerated by continuous shaking, in static broth incubated anaerobically in hydrogen, and on aerobic agar plates, i.e., under conditions not allowing an advantage from pellicle formation. The outgrowth of fim(+) bacteria in aerobic static broth was prevented by the addition of alpha-methylmannoside, a substance that inhibits the adhesive and early pellicle-forming properties of bacteria with type 1 fimbriae. A motile flagellate (fla(+)) variant of a fim(-)fla(-) strain of S. typhimurium outgrew its parent strain in mixed cultures in aerobic static broth, but the selective advantage conferred by motility was weaker than that conferred by fimbriation.


Induction of the lactose transport system in a lipid-synthesis-defective mutant of Escherichia coli. In order to relate the biogenesis of the lactose transport system to lipid synthesis, a glycerol-requiring mutant of Escherichia coli K-12 with a specific defect in l-glycerol-3-phosphate synthesis was isolated and characterized. The defective enzyme is the biosynthetic l-glycerol-3-phosphate dehydrogenase [l-glycerol-3-phosphate: NAD (P) oxidoreductase, EC 1.1.1.8] which functions as a dihydroxyacetone phosphate reductase to provide l-glycerol-3-phosphate for lipid synthesis. In this mutant, removal of glycerol from the growth medium results in inhibition of the synthesis of protein, deoxyribonucleic acid, and phospholipid. Inhibition of phospholipid synthesis immediately follows glycerol removal, whereas the inhibition of deoxyribonucleic acid and protein synthesis is preceded by a short lag period. Glycerol starvation does not change the turnover pattern of previously synthesized phospholipids. The blocking of lipid synthesis by glycerol starvation causes a drastic decrease in inducibility of beta-galactoside transport activity relative to beta-galactosidase, indicating that induction of lactose transport requires de novo lipid synthesis.


Effect of adenosine and deoxyadenosine on the incorporation and breakdown of thymidine in Escherichia coli K-12. Deoxyadenosine (AdR) and adenosine (AR) enhance the incorporation of thymidine (TdR) into bacterial deoxyribonucleic acid (DNA) by the inhibition of TdR phosphorolysis in vivo. Neither of the purine nucleosides has an effect on the reaction catalyzed by TdR phosphorylase in vitro. AdR induces TdR phosphorylase and both purine nucleosides induce purine nucleoside phosphorylase. AR can stimulate uptake of more TdR into bacterial DNA than AdR.


Relationships between body image boundary and interaction patterns on the MAPS test.


Acid phosphatase isoenzyme in human leukocytes in normal and pathologic conditions.


Autoradiographic detection of antigens in cells using tritium-labeled antibodies.


Effects of juvenile hormone and molting hormone on rectal pad development in Hyalophora cecropia (L.).


The effect of free hemoglobin on phagocytosis of Escherichia coli by peritoneal macrophages in vitro.


Mimicry effect of histones in homograft tissue.


Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg.


Respiratory failure from contralateral pneumothorax and atelectasis.


Sir Gordon Holmes (1876-1965).

Sir Gordon Holmes (1876-1965).


Citation indexing for studying science.

Citation indexing for studying science.


Chromosome breakage by deoxyribonuclease.


Follicle stimulating hormone releasing activity in hypophysical portal blood and elevation by dopamine.


Role of macrophages in the development of immunological maturity in rat.


Migration of small lymphocytes from the skin to the regional lymph nodes.


Professor F. T. von Brücke.

Professor F. T. von Brücke.


The critically ill child: management of tracheostomy.


The book of accidents: designed for young children. Published in New Haven in 1830. II. Falls.


Preferable antibiotics for neonatal sepsis.


Bilateral splinting of partial denture abutment teeth.


Functional biochemistry of the macrophage.


Immunologic enhancement.

Immunologic enhancement.


Curable forms of disseminated cancer.

Curable forms of disseminated cancer.


Influenza: consideration of pandemics.

Influenza: consideration of pandemics.


Disorders of water and electrolyte metabolism in liver disease.


Enigma of spermatozoal deoxyribonucleic acid and male infertility: a review.


Pheniformin in insulin-dependent diabetics. Forty-one diabetic patients on insulin were given 100mg. of phenformin daily for six weeks, either before or after a period of six weeks of inert capsules, in a double-blind cross-over trial. Eleven patients while on phenformin noticed hypoglycaemic effects and reduced their insulin on average by almost 20% without resultant rise in blood sugar levels. Twenty-eight patients felt no untoward effects and maintained their usual insulin dose. Phenformin led to improved control of the diabetes, with a significant decrease in blood sugar levels and a significant reduction in the variability of the weekly blood sugar readings. There was no increased ketosis, no change in cholesterol, and no significant loss of weight.


A comparative study of three hypnotics: methyprylon, glutethimide and chloral hydrate. A controlled study designed to evaluate the hypnotic potentiality of methyprylon (300 mg.), glutethimide (500 mg.) and chloral hydrate (1000 mg.) was carried out on 50 in-patients experiencing long-standing insomina. The patients ranged in age from 21 to 60 years, the sexes were equally represented and the clinical diagnoses were psychoneurosis, reactive depression, or anxiety reaction. An interesting feature of the experimental design allowed for the exclusion of placebo reactors before the initiation of the main trials. No difference in effectiveness of maintaining sleep could be established among the three hypnotic agents, indicating that at the usual levels of statistical significance, all three agents were equally effective as hypnotics. However, a significant trend (P = .05) was found for methyprylon (Noludar) to be the most effective and chloral hydrate to be the least effective of the three drugs in maintaining sleep. Methyprylon was found statistically (P = .05) to be the fastest sleep-inducing agent, whereas glutethimide (Doriden) proved to be the slowest of the three hypnotics with respect to sleep induction time.


Selected federal agencies concerned with dental programming.


Metabolism and function of ovarian and testicular hormones.


Ageing and reproduction in the male.

Ageing and reproduction in the male.


Ageing changes in pituitary-ovarian relationships.


Pulmonary angiography--sequential changes during acute rejection of canine lung allografts.


Obstruction of the microcirculation in rejecting canine renal allografts.


What's new in cardiac surgery.

What's new in cardiac surgery.


Developmental sequence and intracellular sites of synthesis of three structural protein antigens of influenza A2 virus. Specific antisera for hemagglutinin (HA) and neuraminidase antigens of influenza A(2) virus (A(2)E) were produced through the segregation of the two proteins in reciprocal viral recombinants of A(2)E and A(0)e viruses. Gamma globulin fractions of these specific antisera and of antiserum specific for the nucleoprotein (NP) antigen of A(0)e virus were conjugated with fluorescein isothiocyanate and employed to follow the synthesis of the three structural proteins in clone 1-5C-4 human aneuploid cells, with parallel measurement of serological and biological activity of the antigens by other techniques. In this system, NP antigen appeared first (at 3 hr) in the cell nucleus, whereas HA and neuraminidase appeared coincidentally, at 4 hr after infection, in the cytoplasm. The initial detectability of biological or complement-fixing activity of the proteins coincided with their demonstrability as stainable antigens. Late in infection, all three antigens were detected at the cell surface. Antibody specific for HA partially blocked the intracellular staining of neuraminidase and inhibited the enzymatic activity of both extracted and intact extracellular virus. These observations suggest the close intracytoplasmic proximity of the two envelope antigens and perhaps their initial association in a larger protein.


Absence of immunity to superinfection in spheroplasts of a lysogen. Penicillin-induced spheroplasts of Salmonella typhimurium strain LT2 lysogenic for bacteriophage P22, appear to lose immunity to superinfection by homologous phage.


Effect of fluorophenylalanine on bacteriophage MS2 replication. A concentration of 10 mug of fluorophenylalanine per ml added to a chemically defined medium reduced by 100-fold the number of bacteriophage MS2 produced on Escherichia coli C3000 and increased the latent period. Fluorophenylalanine was most effective when added concurrent with infection. Addition of a 10-fold greater concentration of phenylalanine reversed the inhibition caused by fluorophenylalanine. Radioactive fluorophenylalanine was incorporated into the coat protein. The four phenylalanine-containing chymotryptic peptides are not equally accessible to fluorophenylalanine. Only two of the peptides are highly labeled by fluorophenylalanine. Incorporation of fluorophenylalanine decreased the specific infectivity and the rate of adsorption but did not increase the sensitivity of the whole virus to ribonuclease. MS2 ribonucleic acid (RNA) functioned as messenger RNA for the incorporation of both phenylalanine and fluorophenylalanine in a cell-free incorporating system from E. coli.


Cephalexin--a new oral antibiotic.

Cephalexin--a new oral antibiotic.


Diploid azaguanine-resistant mutants of cultured human fibroblasts.


Reflections on the history of the concept of time.


Whitehead and the philosophy of time.

Whitehead and the philosophy of time.


Pierre Curie's principle of one-way process.


Time asymmetry, time reversal and irreversibility.


Neuro-ophthalmologic signs and symptoms of occlusive disease of the carotid and vertebral arteries.


Isolation of UGA and UAG nonsense mutants of bacteriophage P22.


A pharmacological approach to the mode of digitalis action.


Evidence for extrachromosomal location of prophage N15.


Infection of primary cultures of aphid cells with a plant virus.


Studies on phage internal proteins: isolation of protein-DNA complexes from T2 phages and from phage-infected bacteria.


Spermidine and spermine--polyamine components of turnip yellow mosaic virus.


Independent assembly of Qbeta and MS2 phages in doubly infected Escherichia coli.


Progress in brain physiology in the present century.


Developmental pathways of research on brain-behavior interrelations in animals.


Corrective massage for atrophic masticatory and mimetic muscles.


Islet and beta cell volumes in offspring of severely diabetic (ketotic) chinese hamsters.


Metabolic abnormalities in the pancreatic islets and livers of the diabetic Chinese hamster.


The retinal vasculature of the Chinese hamster: a preliminary study.


Ultrastructural changes in A-cells exposed to diabetic hyperglycaemia. Observations made on pancreas of Chinese hamsters.


Studies in the diabetic mutant mouse. I. Light microscopy and radioautography of pancreatic islets.


Studies in the diabetic mutant mouse. II. Electron microscopy of pancreatic islets.


Studies in the diabetic mutant mouse. IV. DBM, a modified diabetic mutant produced by outcrossing of the original strain.


The influence of age and dietary conditions on diabetes in the db mouse.


Pathogenetic aspects of the obese-hyperglycemic syndrome in mice (genotype obob). I. Function of the pancreatic B-cells.


Studies of hereditary-obese mice (obob) after implantation of pancreatic islets in Millipore filter capsules.


Differences in the development of the obese-hyperglycemic syndrome in obob and NZO mice.


Metabolic state, pancreatic insulin content and B-cell morphology of normoglycemie spiny mice (Acomys cahirinus): indications for an impairment of insulin secretion.


Diabetes in the KK mouse.

Diabetes in the KK mouse.


Observations on a model of proliferative lung disease. II. Description of pulmonary gas exchange and comparison of Fick and dye cardiac outputs. Measurements of gas exchange in dogs with granulomatous lung disease resembled those which have been made in similar disorders of man. The minute volume of ventilation was large, the oxygen extracted from each liter of ventilation was low, and the arterial blood oxygen saturation tended to be subnormal despite hyperventilation. When the diseased dogs breathed 21% oxygen and had alveolar oxygen tensions above 100 mm Hg, the pulmonary blood flows calculated from the Fick principle were significantly higher than those estimated by the dye-dilution method. By way of contrast, the two values agreed when the alveolar tensions were lowered. Whether the agreement of the flows is causally related to the alveolar tension remains an open question. A possible explanation may lie in the effect of alveolar tension on the oxygen consumed by the diseased lung.


Experimental myocardial infarction. IV. Reduction of left ventricular compliance in the healing phase. Compliance of the infarcted left ventricle was studied in dogs 3-5 days after occlusion of the left anterior descending coronary artery. Compliance was assessed from postmortem pressure-volume curves and from pressure-length measurements (mercury-in-silastic segment length gauges) made both in vivo and postmortem. Postmortem pressure-volume curves showed reduced compliance compared to sham-operated animals. Postmortem pressure-length curves of infarcted and adjacent normal myocardium indicated that the diminished total compliance could be attributed to an increase in stiffness of the infarcted area. This was confirmed by in vivo end-diastolic pressure-length changes produced by transient aortic occlusion. The infarcted area was akinetic, showing neither contraction nor aneurysmal bulging. In addition, anesthetized dogs with infarcts, when compared with sham-operated animals, had similar left ventricular end-diastolic volumes (indicator dilution method), but higher left ventricular end-diastolic pressures. Taken with previous observations, which show that systolic aneurysmal bulging is uniformly present at the onset of ischemia, these results indicate that stiffening of the ischemic myocardium occurs during the first 5 days after infarction, and show that elevation of left ventricular filling pressure does not necessarily signify ventricular dilatation. The results also suggest a mechanism whereby ventricular performance may improve during recovery from acute myocardial infarction.


Synthesis and release of proinsulin and insulin by isolated rat islets of Langerhans. Isolated rat islets of Langerhans were incubated for 60, 120, and 180 min and the incorporation of leucine-(3)H into proinsulin and insulin moieties was followed. Synthesis and release of these hormones could be followed by separate extractions of islets and incubation media. RELEASE OF NEWLY SYNTHESIZED PROINSULIN AND INSULIN OCCURRED UNDER THE FOLLOWING CONDITIONS: (a) incubation for greater than 60 min; (b) glucose concentrations above 5.3 mmoles/liter; (c) incubation with 5 mM dibutyryl cyclic AMP or theophylline in 5.3 mM glucose (potentiated by 16 mM glucose); and (d) incubation with 5 mM tolbutamide and 16 mM glucose. Synthesis of proinsulin and insulin was enhanced by time of incubation, high glucose concentrations, by dibutyryl cyclic AMP or theophylline, and by tolbutamide only at 16 mM glucose. Synthesis was totally inhibited by tolbutamide at 5.3 mM glucose.


Automated diagnosis of arrhythmias by small scale digital computer.


Urinary concentrating ability in early experimental pyelonephritis. The effect of early bilateral pyelonephritis on urinary concentrating ability was studied in rats injected intravenously with enterococci or Staphylococcus aureus and in rats inoculated with Escherichia coli into the medullae of both kidneys. The mean maximum urinary osmolality of normal rats was 2352 mOsm/kg of water. Inoculation of E. coli caused reversible pyelonephritis with sterilization of the kidneys within 12 wk. By 1 day after injection the mean maximum urinary osmolality had decreased to about 1100 mOsm. remained at this level for 3 wk, and then rose to normal by 12 wk. After injection of enterococci and staphylococci, the mean maximum urine osmolality decreased over 3-4 days to about 1000 and 800 mOsm respectively. In the enterococcal infection (which is chronic) the maximum urine osmolality remained about 1200 mOsm for at least 12 wk whereas in the staphylococcal infection (which is reversible) the osmolality gradually rose. Antimicrobial therapy of E. coli renal infection with colistimethate sodium and S. aureus infection with ampicillin rapidly reduced bacterial titers in the kidneys with an associated rise in maximum urinary osmolality. Therapy of enterococcal renal infection with ampicillin produced less impressive decreases in bacterial titers in the kidneys and little or no improvement in urinary concentrating ability. With antimicrobial therapy or with the self-limited infections, the rate of increase in concentrating ability was directly correlated with the rate of decrease of bacterial titers. However, there was poor correlation between histological findings in the kidneys and urinary concentrating ability. These studies demonstrate that early experimental pyelonephritis is associated with a concentrating defect that can be rapidly reversed and therefore is not related to permanent renal damage.


Concepts of stroke before and after Virchow.


Pharmaceutical history and its sources in the Wellcome collections. 3. Fluid medicines, prescription reform and posology 1700-1900.


Richard Morton (1637-1698).

Richard Morton (1637-1698).


Soorjo Coomar Goodeve Chuckerbutty: the first indian contributor to modern medical science.


William Harvey and the foundation of modern haemodynamics by Albrecht von Haller.


A brief history of Jennerian vaccination in Japan.


Medical history in German medical education.


Methods for the description of bile acid kinetics in man.


Chromatography of amino acids on ion-exchange resins.


Chromatography on substituted dextran copolymers.


pH gradient electrophoresis.

pH gradient electrophoresis.


A review of uterine involution and ovarian activity during the postparturient period in the cow.


Alcohol and liver disease.

Alcohol and liver disease.


Biosynthesis of vitamin B6: incorporation of three-carbon units. Pyridoxol, one of the forms of vitamin B(6), is derived from three glycerol units. One of these is incorporated by way of pyruvate as a two-carbon fragment at the oxidation level of acetaldehyde. The other two glycerol units are incorporated intact, possibly by way of triose phosphate.


Discussion effects on racial attitudes.

Discussion effects on racial attitudes. We predicted that discussion would enhance dominant group values, leading to increased polarization between homogeneously composed groups of high-, medium-, and low-prejudice high school subjects. In an experimental condition, group members made individual attitude judgments, discussed them, and remade judgments. Control groups discussed irrelevant materials before responding again to the attitude items. As predicted, discussion of the racial attitude items with others having similar attitudes significantly increased the gap between high- and low-prejudice groups.


Immigration yields.

Immigration yields.


Acanthaster: a rarity in the past?

Acanthaster: a rarity in the past?


The halls of the Barbers, Barber-Surgeons and Company of Surgeons of London.


Veterans Administration cooperative study of surgery for duodenal ulcer. I. Description and evaluation of method of randomization.


Hemodynamic effects of glucagon following hemorrhagic and endotoxic shock in the dog.


Veterans Administration cooperative study of surgery for duodenal ulcer. II. Incidence of wound disruption following operation.


Role of the atrial myocardium in the pathogenesis of the "shock lung".


Edwin L. Crosby, M.D.--recipient of the 1970 Justin Ford Kimball Award.


The total somatic cell count related to the bacterial growth from cow fore-milk samples.


Water pollution--an ecological perspective.


Rotary shaker suitable for fixation and infiltration of histological specimens at reduced temperatures.


A continuous flow turbidostat.

A continuous flow turbidostat.


Narcotic antagonists in opiate dependence.


Birth control after 1984.

Birth control after 1984. 1) Eric Blair (alias George Orwell) can rest easy in his grave, because birth control by governmentally imposed methods, such as incorporation of a contraceptive agent into drinking water, is totally unfeasible by 1984. 2) Fundamentally new birth control procedures in the female (for example, a once-a-month luteolytic or abortifacient agent) and a male contraceptive pill probably will not be developed until the 1980's at the earliest, and then only if major steps of the type outlined in this article are instituted in the early 1970's. Development during the next decade of practical new methods of birth control without important incentives for continued active participation by the pharmaceutical industry is highly unlikely. If none are developed, birth control in 1984 will not differ significantly from that of today.


Enzyme replacement in Fabry's disease, an inborn error of metabolism. Two patients with Fabry's disease were infused with normal plasma to provide active enzyme (ceramide trihexosidase) for hydrolysis of the plasma substrate, galactosylgalactosylglucosylceramide. Maximum ceramide trihexosidase activity occurred 6 hours after infusion of the plasma, attaining a level approximately 150 percent of that in normal plasma; enzymatic activity was detectable for 7 days. The amount of accumulated substrate in the plasma of these recipients decreased about 50 percent on day 10 after infusion. Thus, periodic replacement of ceramide trihexosidase activity in the plasma of patients with Fabry's disease might lead to consistently lower amounts of substrate in the plasma and a decrease in its rate of accumulation in tissues.


In memoriam. Lorel A. Stapley, M.D. 1922-1968.


Cell to cell injury mediated through alloantibodies.


RNA polymerase from eucaryotic cells.

RNA polymerase from eucaryotic cells.


The immune response of germ-free piglets after peroral monocontamination with living Escherichia coli strain 086. I. The fate of antigen, dynamics and site of antibody formation, nature of antibodies and formation of heterohaemagglutinins.


Vocational guidance in the Ivy League.

Vocational guidance in the Ivy League.


Some physicochemical properties of anthranilate synthetase component I from Salmonella typhimurium.


Purification and properties of a palmityl thioesterase II from Escherichia coli.


Gnats and camels: a matter of reasonableness.


Studies on photodynamic action. II. The action on Escherichia coli cells.


Heterotransplanted spleen tissues in diffusion chambers: therapeutic benefits to irradiated mice.


Interactions of lymphocytes and macrophages from human colostrum: characteristics of the interacting lymphocyte.


The marihuana-induced "social high". Neurological and electroencephalographic concomitants.


List no. 92. New names.

List no. 92. New names.


Corneille Heymans (1892-1968).

Corneille Heymans (1892-1968).


Need for controlled study.

Need for controlled study.


The antitumor action of bacterial extract. I. Suppression of mouse ascites tumors by the treatments with extracts of E. coli.


Application of the antibody against soluble GBM substance to the immunofluorescence staining of kidney sections.


The American College of Surgeons--today and tomorrow.


Suppression and the sequential appearance of the galactose enzymes in a transferase amber mutant of E. coli.


Caffeine-death in Escherichia coli.

Caffeine-death in Escherichia coli.


Absorption, distribution and metabolic fate of psychotropic drugs.


Assay of phenothiazines and metabolites.


Progress in nephrology, renal dialysis and transplantation.


In memoriam: Servase Meyer de Kock, M.B., Ch.B.


In memoriam: Corenelius Hermanus Hubertus Coetzee, M.B., Ch.B.


Technics for culturing Mycoplasma species from clinical specimens.


Metabolism of radioactive 17alpha-ethynylestradiol by women. Data on the urinary excretion and subsequent fractionation of radioactivity derived from 6,7-tritiated-17alpha-ethinyl estradiol (tritiated EE) are presented.  Tritiated EE was administered orally to 9 women.  17alpha-ethinyl estradiol 2-methoxy-17alpha-ethinyl estradiol, 2 -hydroxy-17alpha-ethinyl estradiol 3-methyl ether, and D-homoestradiol-1 7abeta were identified as urinary metabolites by reverse isotope dilution.  The extent of D-homoannulation was much less than that reported previously with rabbits.


Evaluation of a reagent-impregnated strip for detection of nitrate reduction by bacterial isolates.


Crime, cricket, and Conan Doyle--more on the sporting doctor.


History and epidemiology of coalworkers' pneumoconiosis.


The effect of glucose and galactose on catalase activity of Salmonella typhimurium in aerobic and anaerobic cultures.


The anesthesiologist and the cardiac surgeon.


Explosive tear gas injuries of the eye.

Explosive tear gas injuries of the eye.


The risk of anesthesia.

The risk of anesthesia.


Reversible bone marrow suppression from chloramphenicol. A consequence of mitochondrial injury.


Immediate hemodynamic effects of gram-negative vs gram-positive bacteremia in man.


Central nervous system cytopathological changes in cats with chronic methedrine intoxication.


The distribution of clostridia in poultry processing plants.


The 70th birthday of Prof. Frantisek Herles.


Surgery in the rehabilitation of cerebral palsied patients.


Dr. J. William Hillman.

Dr. J. William Hillman.


Ontogenetic development of the male-specific antigen in mice.


Factors influencing the blast reaction in regional lymph nodes of rabbits.


Action of adenosine on RNA of the nucleolus.


George Walker (1869-1937).

George Walker (1869-1937).


Effect of oxygen on freezing damage. I. Effect on survival of Escherichia coli B-r and Escherichia coli Bs-1.


History of Children's Hospital of the District of Columbia.


Renal injury: suture versus n-butyl cyanoacrylate tissue adhesive spray repair.


Serum antibody effect on induced bladder infection.


Observations on initial segments of axons in the prepyriform cortex of the rat.


Blind Rehabilitation Program. Physical Medicine and Rehabilitation Service. Veterans Administration Center, Togus, Maine.


The response of lysosomes in cultured neurons to chlorpromazine.


A good diagnosis.

A good diagnosis.


Preservation of canine hearts.

Preservation of canine hearts.


Serratia marcescens infections from inhalation therapy medications: nosocomial outbreak.


Immunogenetics of consanguineous allografts in man. I. Histocompatibility testing and skin allografts.


Ovarian tumors associated with the Peutz-Jeghers syndrome.


Immunogenetics of consanguineous allografts in man. II. Correlation of renal allografting with HL-A genotyping.


Exploring surgical treatment for myocardial infarction.


Long-term follow-up of direct current cardioversion after cardiac surgery with special reference to quinidine. The results of the long-term follow-up of 119 patients who had DC cardioversion performed are described. All patients had had corrective cardiac surgery for chronic rheumatic valvar heart disease. The poor prognosis for maintenance of sinus rhythm in this type of patient is emphasized. Of the total patients, 83 per cent were converted to sinus rhythm, but relapses were common in those who had atrial fibrillation before operation. Only 40 per cent of such patients maintained sinus rhythm for 2 months, 15 per cent for 1 year, and 9 per cent for 2 years.By contrast, when atrial fibrillation occurred for the first time in the post-operative period, 82 per cent maintained sinus rhythm for 2 years after conversion.Post-operative DC cardioversion is in general not recommended for patients with rheumatic heart disease and atrial fibrillation unless atrial fibrillation occurs for the first time in the post-operative period. A controlled trial of prophylactic quinidine is reported and shows no significant increase in the number of patients remaining in sinus rhythm as compared with a control group not receiving quinidine.


Evan Jones.

Evan Jones.


Closed-chest cardiac resuscitation at the end of the 18th century.


A comparison of infrared photography and thermography in the detection of mammary carcinoma.


A study of the "string" test in vibrio identification.


Third progress report on the British Institute of Radiology fractionation study on 3F-week or 5F-week treatment of larynx and pharynx.


Implantation of allogeneic heart grafts in inbred mice.


Profundus tendon grafting with unimpaired sublimus function in children.


Anti-inflammatory effect of acetylsalicylic acid in rheumatoid arthritis.


Benign unicameral bone cyst. A study of forty-five cases with long-term follow up.


Historical aspects of gout.

Historical aspects of gout.


Osteoarthritis of the hip. A review with special consideration of the problem of bilateral malum coxae senilis.


The classic: a treatise on gout. Alfred Baring Garrod.


Effects of neonatal thymectomy on implantation of heart grafts in inbred mice.


Surgical management of tophaceous gout.

Surgical management of tophaceous gout.


Specific and non-specific opsonins.

Specific and non-specific opsonins.


Nontuberculous mycobacterial diseases.

Nontuberculous mycobacterial diseases.


The prevention of (viral) hepatitis.

The prevention of (viral) hepatitis.


The Stevens-Johnson syndrome.

The Stevens-Johnson syndrome.


Electrical calibration for the saline-dilution method for cardiac output.


Human growth hormone.

Human growth hormone.


Tryptophanyl transfer RNA synthetase and expression of the tryptophan operon in the trpS mutants of Escherichia coli.


A Salmonella typhimurium locus involved in the regulation of isoleucine, valine and leucine biosynthesis.


Homotransplantation of the heart: a synopsis.


Simple methods for detection of bacteriuria in the physician's office.


Successful five-day kidney preservation. Perfusion with hypothermic, diluted plasma.


A case of renal thrombotic thrombocytopenic purpura with comments on coagulation and immunofluorescent studies.


William Cheselden (1688-1752).

William Cheselden (1688-1752).


Hypno-ophthalmic therapy--fact or fallacy.


Physical therapy for children with intractable asthma.


Forensic aspects of tear-gas pen guns.

Forensic aspects of tear-gas pen guns.


A double-blind evaluation of Tenuate dospan in overweight patients from a private gynecologic practice.


Gout and rheumatism at the Reynolds Historical Library.


Bile canaliculus and space of Disse. Electron microscopic relationships as delineated by lanthanum.


The history of medical microbiology at the University of Manitoba.


Future horizons in clinical pharmacology.


James Minor, M.D. (1785-1828): the correspondence of a medical student, 1803-1807.


180th Anniversary Reception: president's address.


Memoir of Edward Thomas Crossan. 1890-1966.


Memoir of James Ewing Cottrell. 1898-1967.


Memoir of Damon Beckett Pfeiffer. 1878-1966.


Memoir of John. A. Brooke. 1874-1967.

Memoir of John. A. Brooke. 1874-1967.


Philadelphia medicine in 1841 as seen by a visiting physician.


Memoir of John Westgat Hope 1914-1969.

Memoir of John Westgat Hope 1914-1969.


Memoir of George Snyder, Jr. 1908-1969.

Memoir of George Snyder, Jr. 1908-1969.


Gluteal flaps in the closure of sacral decubitus.


Your new president. William Grossman, M.D.


Glyoxylate carboligase from E. coli: specificity of the enzyme for unhydrated glyoxylate.


Identification of the sites of binding of acetyl and malonyl groups to the pigeon liver fatty acid synthetase complex.


The chemistry of sheep anterior lens capsule.


An electron microscopic study of a syphilitic chancre. Engulfment of Treponema pallidum by plasma cells.


Peyton Rous.

Peyton Rous.


Chymotrypsin inhibitor 1 from potatoes: a multisite inhibitor composed of subunits.


Skin closure in myelomeningocele. A technical note.


Historical note: Osler's brain.

Historical note: Osler's brain.


The origin of blood monocytes and macrophages. A review.


Adaptation of skeletal muscle to overloading--a review.


Janusz Korczak, M.D. In commemoration of the 25th anniversary of his tragic death.


Ultrastructural observations on early cartilage calcification. The use of chromium sulphate in decalcification.


Vincristine (NSC-67574) therapy for acute leukemia in children.


5(or 4)-(3,3-dimethyl-1-triazeno)imidazole-4(or 5)-carboxamide (NSC-45388): microbiologic assay in mouse tissues.


Clinical trial with dihydroxybusulfan (NSC-39069).


Hydroxyurea (NSC-32065) with irradiation for cervical carcinoma--preliminary report.


Wolf children--truth or fallacy?

Wolf children--truth or fallacy?


Escherichia coli osteomyelitis in an infant with sickle-cell disease.


The revolution in cardiac diagnosis.

The revolution in cardiac diagnosis.


Aortography in the investigation of traumatic mediastinal haematoma.


Cor Pulmonale. Including a short note on pulmo cordis (cardiac lung disease).


Fluorine-18 production for medical use by helium-3 bombardment of water.


Immunity to mastitis. A review.

Immunity to mastitis. A review.


Complement and conglutinin in the serum of germ-free and conventional piglets.


The effects of a blockading agent on the primary immune response.


Development of antibody-forming cells in neonatal mice: stimulation and inhibition by calf thymus fractions.


Degrees of freedom open to new and developing medical schools in the utilization of Veterans Administration hospitals.


Recommended criteria for the identification of trachoma and inclusion conjunctivitis agents.


Sensitivity of Salmonella typhimurium recombinationless (rec) mutants to visible and near-visible light.


Editorial. The Journal and its editors.

Editorial. The Journal and its editors.


Recent research.

Recent research.


Pandemic influenza: an unresolved problem in prevention.


The early history of the Auckland hospital.


Finger tip amputations: The Kutler technique of repair.


Poison or medicine?

Poison or medicine?


A comparative study of the pathogenesis of western equine and eastern equine encephalomyelitis viral infections in mice by intracerebral and subcutaneous inoculations.


Voluntary sterilisation in the male.

Voluntary sterilisation in the male.


The effect of the supply of oral antibiotic on the fecal flora and mortality of mouse radiation chimeras.


Sir Frances Gordon Bell.

Sir Frances Gordon Bell.


In-vitro interaction of Shigella flexneri with leukocytes and HeLa cells.


Effect of physical stress on the elementary bodies and colony-forming units of mycoplasmas.


Robert Findlay Allen.

Robert Findlay Allen.


Nursing managers--what should they read? 2.


Vaginitis: concepts of a broad-spectrum therapy.


A new operation for male incontinence.

A new operation for male incontinence.


John Hunter and tissue transplantation.

John Hunter and tissue transplantation.


The revolt of youth: some historical comparisons.


The effect of intravenous ethanol on the bactericidal activity of human serum.


Neonatal colibacillosis in calves and pigs.


Mastitis in slaughtered dairy cows. 1. Udder infection.


The value of passive hemagglutination reaction in the diagnosis of pyelonephritis.


Prof. Odon Bujwid 1857-1942, a pioneer of Polish bacteriology and public health.


Jimenez-Diaz.

Jimenez-Diaz.


Observations and comments concerning the isolation of group B beta-hemolytic streptococci from human sources. A marked increase in the isolation of Group B streptococci from patients in the University Hospital, Saskatoon, has been noted over the past four years, and no change in technical methods has been found to explain this increase. Group B streptococci have been isolated from 242 patients, in 53 of whom the streptococcus was considered the cause of the infection. Infections occurred predominantly in the urinary tract, female genital tract and upper respiratory tract. There was a low incidence of infections in newborn infants, and only four infections were in patients under 1 year old. Infections were more frequent in women than men and in patients over 40 years of age. No particular affinity of Group B streptococci for diabetics was demonstrated.


The unsettled question: butter or margarine?


Intermittent positive-pressure breathing in chronic obstructive pulmonary disease.


Medicare and Medicaid.

Medicare and Medicaid.


Early Delaware physicians. V. Nathaniel Luff, Delaware physician during the revolutionary period, 1776-1787.


Plasma-renin activity in three human heart transplants.


The effect of live attenuated Venezuelan equine encephalomyelitis virus vaccine on serum iron, zinc, and copper concentrations in man.


Streptococcal group A carbohydrate antibody in rheumatic and nonrheumatic bacterial endocarditis.


Riboflavin metabolism.

Riboflavin metabolism.


Antibody standards for antibodies.

Antibody standards for antibodies.


In vitro evidence for cellular hypersensitivity to glomerular-basement-membrane antigens in human glomerulonephritis.


Corticosteroid therapy in ulcerative colitis.


Mechanisms of insulin secretion.

Mechanisms of insulin secretion.


Hazards of phototherapy.

Hazards of phototherapy.


Childhood sciatic palsies: congenital and traumatic.


Misadventures in anaesthesia.

Misadventures in anaesthesia.


Cancer of the lip.

Cancer of the lip.


Medical taxonomy.

Medical taxonomy.


Synthesis of showdomycin.

Synthesis of showdomycin.


Professeur Virgil Racoveanu (1898-1967).


Ethics in kidney transplantation.

Ethics in kidney transplantation.


Scanning electron microscopy of the lens of the adult rat.


Relationship between particle size and biological activity of Salmonella typhimurium endotoxin.


Intensive care of small premature infants. I. Clinical findings and results of treatment.


Osteoblasts and osteoclasts in bone marrow aspirated from children with rickets.


Nuchal naevi and interscapular telangiectases.


Studies on the subcutaneous absorption in mice. VIII. Influence of connective tissue ground substance on the absorption of subcutaneously injected depots of sodium and chloride.


Studies on the subcutaneous absorption in mice. VII. Absorption of 3H2O and 14C-sucrose from non-buffered solutions at different pH values.


Enteric colibacillosis in gnotobiotic swine: a fluorescence microscopic study.


Enteric colibacillosis in gnotobiotic swine: an electron microscopic study.


Microflora of Hormel miniature swine: fecal flora of adult sows.


Occurrence and ecologic features of Streptococcus uberis in the dairy cow.


Histologic and histochemical changes in cutaneous lesions of experimentally induced and naturally occurring canine demodicidosis.


Antibiotics of the penicillin and cephalosporin family.


Clinical and pharmacologic experience with dibromodulcitol (NSC-104800). A new antitumor agent.


Hydroxyurea (NSC-32065) intermittent therapy in malignant diseases.


The action of caerulein on gastric secretion of the chicken.


Autoantibodies in the Carterton population survey. The prevalence of thyroid and gastric antibodies, antinuclear and rheumatoid factors, in a probability based population sample.


Chromosome replication in Escherichia coli 15T- at different growth rates: rate of replication of the chromosome and the rate of formation of small pieces.


Regulation of lambda exonuclease synthesis: role of the N gene product and lambda repressor.


Synthesis and assembly of ribosomal protein into 50 s subunits during recovery from methionine starvation.


Ultrastructural aspects of neutrophil granulocyte development in humans.


In situ labeling of popliteal lymph node cells with tritiated thymidine in rats with allergic adrenalitis.


Cyclic and step-up administration of ethynodiol diacetate as an oral contraceptive.


Caesarean section and its early Australian history.


Stimulation of staphylokinase production by mitomycin C.


Thymus and node labelling by intramediastinal injection of tritiated tracers and its bearing on present concepts of lymphocyte cytokinetics.


On the taxonomy of some members of the Enterobacteriaceae family.


A contribution to the occurrence of E. coli O 124:K 72.


Micromonospora taxonomy.

Micromonospora taxonomy.


The recovery and purification of biochemicals.


The microbiology of the hen's egg.

The microbiology of the hen's egg.


Drierite as a dehydrant, indicator, and marker for paraffin embedded tissues.


Effect of sulfhydryl reagents on permeability of toadfish islet tissue.


Treatment of congestive heart failure with glucagon.


Cardiac disease and its treatment--some physiological correlations.


The cephalosporins. Microbiological, chemical, and pharmacological properties and use in chemotherapy of infection.


Clinical science, research, and academic advancement.


The old private lunatic asylum at Fishponds.


Otology in the South West.

Otology in the South West.


Corneal granular dystrophy. A light and electron microscopical study of its recurrence in a graft.


Conjunctival and corneal changes in renal failure. Influence of renal transplantation.


Psychiatry in traditional Chinese medicine.


A biochemical survey of schizophrenia.

A biochemical survey of schizophrenia.


Estimation of the total body vitamin B12 in the live subject.


Studies of insect spermatozoa. I.

Studies of insect spermatozoa. I.


Joseph L. Williams (1906-1965).

Joseph L. Williams (1906-1965).


Amoeboid movements and cytoplasmic fragmentation of glycerinated leukocytes induced by ATP.


Prevention of origin of adenosine effect in nucleolus under influence of RNase and pepsine.


G2-population cells in mouse kidney and duodenum and their behavior during the cell division cycle.


Terminal lens cell differentiation. I. Histological and microspectrophotometric analysis of nuclear degeneration.


Diminished bile acid pool size in patients with gallstones.


Diffuse esophageal spasm: a disorder with more than one cause.


Sustained gastric secretion in response to 2-deoxy-D-glucose. Indefatigability of the vagal mechanism.


List of available training programs.

List of available training programs.


Light and electron microscopic studies on the pancreatic acinar and islet cells in Xenopus laevis.


The possible significance of childhood object loss in the Josef Breuer-Bertha Pappenheim (Anna O.)-Sigmund Freud relationship. I. Josef Breuer.


A further contribution to the "Kernel of Truth" in Schreber's delusional system.


Freud's considerations of the mental processes. An attempt at a unifying treatment.


Aflatoxin as a health hazard.

Aflatoxin as a health hazard.


Diffusion of the intravenous technique among narcotic addicts in the United States.


Dr. Bulbulian honored by alma mater.

Dr. Bulbulian honored by alma mater.


Clinical and laboratory investigation of a ceramic-filled acrylic resin compound.


Screw-type attachments for fixed partial dentures.


Prosthetic management of postsurgical soft palate defects.


Treatment obturators for edentulous patients.


Uptake of thiamine propyl disulfide in Escherichia coli.


Causation of Ouch-Ouch Disease (Itai-Itai Byõ)--an introductory review. I. Nature of the disease.


Epidemic of mercury poisoning in the Agano River area--an introductory review.


Causation of Ouch-Ouch Disease (Itai-Itai Byõ)--an introductory review. II. Epidemiology and evaluation.


Genesis, growth, and therapy of tumors: mathematical models.


"A singular case" and Dr. Smethurst.

"A singular case" and Dr. Smethurst.


1970 Membership Directory Greater Kansas City Dental Society.


The "mini-lift," an old wrinkle in face lifting.


Double V-Y procedure for whistling deformity in repaired cleft lips.


Correction of hypertrophy of the upper lip.


Ambroise Paré. His contributions to plastic surgery.


When an "ellipse" is not an ellipse.

When an "ellipse" is not an ellipse.


Loss of flaps due to glucose-6-phosphate dehydrogenase deficiency. Case report.


Disease of the small bowel in childhood.


A study of the paintings of Vermeer of Delft.


Cytologic, cytochemical and immunocytochemical pattern of synovial fluid in rheumatoid arthritis, in related diseases and in posttraumatic effusions.


Nucleolar structure during the meiotic prophase in Allium cepa anthers.


Recent developments in chemical modification and sequential degradation of proteins.


Partition of cell particles and macromolecules in polymer two-phase systems.


Selective cleavage and modification of peptides and proteins.


The William K. Stewart memorial lecture-1969. Anglo-American military aviation medicine.


Coordination of ventilation and perfusion.


Surgery of the thymus.

Surgery of the thymus.


Parallelity.

Parallelity.


Newer analgesics: with special reference to pentazocine.


The benzodiazepines. A review of their actions and uses relative to anaesthetic practice.


Pharmacology of drugs used in neuroleptanalgesia.


Frederick Samuel Lawson 1903-1970.

Frederick Samuel Lawson 1903-1970.


Donald Griffith McKerracher, 1909-1970.

Donald Griffith McKerracher, 1909-1970.


Spruing for bridge wax patterns.

Spruing for bridge wax patterns.


Thromboembolism: a manifestation of the response of blood to injury.


Psychopharmacology of the lithium ion (twenty years after).


The biosynthesis of multichain proteins.


The structure of collagen.

The structure of collagen.


The synthesis and metabolic control of polysaccharides and lignin during the differentiation of plant cells.


The adenohypophysis of female rats after hypothalamic oestradiol implants: an electron microscopic study.


Structure and function of the plasma membrane. A biochemical perspective.


Mediated (nonactive) transport of glucose in mammalian cells and its regulation.


The ultrastructural basis of transcapillary exchanges.


Patterns of protein synthesis in Escherichia coli infected by amber mutants in the first-step-transfer DNA of T5.


Analogues of nucleoside polyphosphates. II. Guanosine-5'-phosphohypophosphate: preparation and effects on protein synthesis in vitro.


Repressor-insensitive mutants of the F sex factor.


Studies on the fate of parental bacteriophage RNA in the host.


A physical study by electron microscopy of the terminally reptitious, circularly permuted DNA from the coliphage particles of Escherichia coli 15.


Optical rotatory dispersion and circular dichroism properties of yeast mitochondrial DNA's.


Lac repressor-operator interaction. I. Equilibrium studies.


Chromosome transfer during bacterial mating.


RNA metabolism in T4-infected Escherichia coli.


Chromosome replication in Escherichia coli. 3. Segregation of chromosomal strands in multi-forked replication.


Intermediates in the assembly of phi X174.


Replication of the single-stranded DNA bacteriophage M13: absence of intracellular phages.


Some psychiatric aspects of abortion.

Some psychiatric aspects of abortion.


1970 Membership Roster, Southern California Dental Association.


President's address. William L. Perry, M.D. to the South Carolina Medical Association, May 11, 1970.


Urological management of the meningomyelocele patient.


Continuing education courses for physicians.


An improved method for heterotopic cardiac allografting.


Meningiomas of the cerebello-pontine angle and their relation to the temporal bone.


Obituary.

Obituary.


Fate of human fertilized eggs during prenatal life: present status of knowledge.


Results of the use of artificial arteriovenous shunt of Scribner.


The regulation of enzyme activity and allosteric transition.


Power failure in acute myocardial infarction.


Computers in cardiology.

Computers in cardiology.


Comparative studies on ultrastructure of the pigmented and albino hyphae of Microsporum cookei.


Lipids of human red cell membrane: normal composition and variability in disease.


Further studies on the control of E. coli in weaned pigs by chemical supplementation of the feed.


Malaria.

Malaria.


Irreversible inactivation of Escherichia coli alkaline phosphatase with active site directed alkylating reagents.


Study of the mechanical events of the left ventricle by atrumatic techniques: comparison of methods of measurement and their significance.


Combinations of diuretics in the treatment of edema.


Biography of Prof. Toshio Ito.

Biography of Prof. Toshio Ito.


Light and electron microscope observations on the islets of Langerhans in Carassius carassius longsdorfii.


The endocrine cells of human duodenal mucosa. An electron microscope study.


Laboratory diagnosis of rubella.

Laboratory diagnosis of rubella.


Diabetes: underlying biochemical lesions.


Expectorant action of bromhexine in chronic obstructive bronchitis. Bromhexine was compared with a placebo in a double-blind clinical trial in bronchitic inpatients with mucoid sputum. Oral bromhexine 16 mg. thrice daily for 11 days compared with placebo resulted in a significant increase in sputum volume and significant decrease in sputum viscosity, and changed markedly the rheological characteristics of the sputum. There was, however, no improvement in ventilatory capacity or in the overall respiratory state as assessed by the patients themselves or their clinician. No patient having the drug had side-effects and there was no change in laboratory findings attributable to it.


Paget's disease of bone.

Paget's disease of bone.


Vitamin E-selenium deficiency in swine: differential diagnosis and nature of field problem.


Resistogram typing--a new epidemiological tool: application to Escherichia coli.


The transfer of antibiotic resistance between strains of enterobacteria in chicken, calves and pigs.


Bacteria in renal casts.

Bacteria in renal casts.


A note on the presence of Mycobacterium leprae in the central nervous system of a mouse with lepromatous leprosy.


The detection of myoid cells in the human foetal and neonatal thymus by immunofluorescence.


A study of the localisation of a protein antigen in the chicken spleen and its relation to the formation of germinal centres.


The influence of death upon hero-identification among psychiatric patients.


One-stage hypospadias repair.

One-stage hypospadias repair.


Effect of administration of tetracycline in pregnancy on the primary dentition of the offspring.


Prolongation of skin allograft survival with spleen extracts and antilymphocytic serum.


Rejection of skin allografts by radiation chimaeras: selective gene action in the specification of cell surface structure.


Initiation of haemoglobin synthesis by methionyl-tRNA.


Quantitative study of cells reacting to skin allografts.


Tetrahydrocannabinol isomers and homologues: contrasted effects of smoking.


Specificity of internal signals in producing satiety for taste stimuli.


Some factors controlling ureteral peristalsis.


Malaria.

Malaria.


Multiple invasion of erythrocyte by malaria parasites.


Frederic C. Bartter.

Frederic C. Bartter.


Tubular cytoplasmic bodies in pancreatic islet B-cells of mice.


Factors determining the degree of anaerobiosis of Bifidobacterium strains.


Utilization of betaine aldehyde by choline (chol-) mutants of Neurospora crassa.


Physical properties of ribosomal ribonucleic acid isolated from bacteria deficient in ribonuclease I. 1. Bacteria deficient in ribonuclease I were used as a source of stable ribosomal RNA. RNA was isolated from a ribosome fraction of Pseudomonas fluorescens N.C.I.B. 8248 and acetone-treated cells of Escherichia coli M.R.E. 600 by the method developed by Robinson & Wade (1968). 2. The s(20,w) of the 16S and 23S components can vary from 21S and 28S down to 4S depending on the RNA macro-ion concentration and the extent to which charge is suppressed by univalent Na(+) and tris(+) counter-ions or neutralized through the binding of bivalent Mg(2+) to phosphate groups. 3. The primary charge effect in sedimentation and the frictional coefficient (which increases as the molecular conformation expands) both increase with charge and cause a decrease in s value. 4. RNA solutions heated to 80 degrees C for 10min show minor changes in s value and a detectable increase in polydispersity. Millimolar concentrations of Mg(2+) promote heat-instability and so does treatment of RNA solutions with the nuclease adsorbent macaloid, which was found to contaminate the solutions with Mg(2+). 5. The stabilization of secondary structure by univalent and bivalent cations was investigated by optical methods. 6. The sedimentation properties of 30S and 50S ribosomal subunits and their constituent 16S and 23S RNA components were compared and discussed from the viewpoint of unfolding.


Withdrawal of antipsychotic drugs from chronic psychiatric patients.


A presumptive test for vibrios: the "string" test.


Frequency of tetracycline resistance and infectious resistance transfer in coliform bacteria.


Tris (hydroxymethyl) aminomethane (THAM) induced stimulation of insulin release by islets of Langerhans previously isolated from rat pancreas.


Preliminary clinical evaluation of glybenclamide in treatment of diabetes mellitus.


Comparison of the anti-EBV titer and the EBV-associated membrane reactive and precipitating antibody levels in the sera of Burkitt lymphoma and nasopharyngeal carcinoma patients and controls.


Prolactin and mammary gland carcinogenesis. The problem of human prolactin.


The effect of smooth muscle on the intercellular spaces in toad urinary bladder. Phase microscopy of toad urinary bladder has demonstrated that vasopressin can cause an enlargement of the epithelial intercellular spaces under conditions of no net transfer of water or sodium. The suggestion that this phenomenon is linked to the hormone's action as a smooth muscle relaxant has been tested and verified with the use of other agents effecting smooth muscle: atropine and adenine compounds (relaxants), K(+) and acetylcholine (contractants). Furthermore, it was possible to reduce the size and number of intercellular spaces, relative to a control, while increasing the rate of osmotic water flow. A method for quantifying these results has been developed and shows that they are, indeed, significant. It is concluded, therefore, that the configuration of intercellular spaces is not a reliable index of water flow across this epithelium and that such a morphologic-physiologic relationship is tenuous in any epithelium supported by a submucosa rich in smooth muscle.


Cytoplasmic filaments of Amoeba proteus. I. The role of filaments in consistency changes and movement. The role of filaments in consistency changes and movement in a motile cytoplasmic extract of Amoeba proteus was investigated by correlating light and electron microscopic observations with viscosity measurements. The extract is prepared by the method of Thompson and Wolpert (1963). At 0 degrees C, this extract is nonmotile and similar in structure to ameba cytoplasm, consisting of groundplasm, vesicles, mitochondria, and a few 160 A filaments. The extract undergoes striking ATP-stimulated streaming when warmed to 22 degrees C. Two phases of movement are distinguished. During the first phase, the apparent viscosity usually increases and numerous 50-70 A filaments appear in samples of the extract prepared for electron microscopy, suggesting that the increase in viscosity in caused, at least in part, by the formation of these thin filaments. During this initial phase of ATP-stimulated movement, these thin filaments are not detectable by phase-contrast or polarization microscopy, but later, in the second phase of movement, 70 A filaments aggregate to form birefringent microscopic fibrils. A preparation of pure groundplasm with no 160 A filaments or membranous organelles exhibits little or no ATP-stimulated movement, but 50-70 A filaments form and aggregate into birefringent fibrils. This observation and the structural relationship of the 70 A and the 160 A filaments in the motile extract suggest that both types of filaments may be required for movement. These two types of filaments, 50-70 A and 160 A, are also present in the cytoplasm of intact amebas. Fixed cells could not be used to study the distribution of these filaments during natural ameboid movement because of difficulties in preserving the normal structure of the ameba during preparation for electron microscopy.