Five-year winter chemoprophylaxis for chronic bronchitis. Seventy-nine patients with chronic bronchitis were randomly allotted to four treatment regimens-placebo throughout the winter months for five years; tetracycline for the first two winters and placebo for the next three; placebo for the first two winters and tetracycline for the next three; and tetracycline for five winters. In addition all groups recevied a five-day course of tetracycline for any acute exacerbation. There was a significant reduction in the number of exacerbations among the more susceptible patients-that is, those who suffered more than one exacerbation each winter. Though the average decline in F.E.V.(1) over the five-year period was less in the treated groups this was not statistically significant. There was no significant difference between the groups in respect of lung volumes, diffusing capacity, and blood gases.


Changes in leucocyte migration after renal transplantation. The leucocyte migration test, an in-vitro measure of cellular immunity, has been used to follow the changes in cell-mediated hypersensitivity to kidney and histocompatibility antigens in three patients after renal transplantation.Inhibition of leucocyte migration, indicating strong sensitization to the antigens used, occurred in each patient, starting five to seven days after transplantation. Satisfactory renal function had not been established in any of the patients at this time. In one case inhibition of leucocyte migration persisted almost continuously until the 24th day and was associated with poor renal function proved histologically to be due to rejection. Treatment with increased dosage of prednisone was associated with a rapid reversion to normal of the migration index and improvement in renal function. Later, inhibition of migration occurred again, and shortly afterwards the graft ceased to function. In the other two cases the migration index became normal without alteration in immunosuppressive therapy and a satisfactory diuresis followed. It is suggested that this simple test should prove useful in the specific diagnosis of rejection and in control of immunosuppressive therapy.


Glycoproteins: their fundamental structure, biosynthesis and enzymatic degradation.


The second Sir Hans Krebs Lecture. Informosomes.


Pedicle-meatal skin graft myringoplasty.


5S RNA. An analysis of possible base pairing schemes.


The great ether controversy: a strange interlude in the history of American medicine.


High anti-EB virus titer in sera of patients with nasopharyngeal carcinoma: a small-scaled seroepidemiological study.


Studies on phiX174 proteins. I. Phage-specific proteins synthesized after infection of Escherichia coli.


Coding properties of two conformations of tryptophanyl-tRNA in Escherichia coli.


Electrophoretic characterization of phiX174-specific proteins.


Synthesis and assembly of bacterial membrane components. A lipopolysaccharide-phospholipid-protein complex excreted by living bacteria.


Heat denaturation of P2 bacteriophage DNA: compositional heterogeneity.


The role of government in future medical practice.


Medical-social conditions of slaves in the South.


Kirwood General Hospital. Detroit, Michigan.


Ecological and physiological implications in the selection of trypanosome strains during cyclic transmission.


Preparation and properties of 2-benzoxazolinones.


Permanent cannula-injection system for intracerebral injections in small animals.


Water pollution. Systems analysis.

Water pollution. Systems analysis.


Trial of Astiban in treating university students in the Sudan.


Antigenicity of Clostridium botulinum type-E formol toxoid.


Integration of chloramphenicol resistance gene of an R factor on Escherichia coli chromosome.


Demonstration of R factors in enteric bacteria isolated at the Boston City Hospital.


Establishment of Candida albicans in the alimentary tract of the germ-free mice and antagonism with Escherichia coli after oral inoculation.


High incidence of Japanese infants with antibody to a herpes-type virus associated with cultured Burkitt lymphoma cells.


A few kind words about W. Somerset Maugham (1874-1965).


Disordered respiratory function in emphysema.


The place of medical history in undergraduate education.


Some environmental carcinogens.

Some environmental carcinogens.


The microflora of the stagnant loop syndrome.


Measurement of feelings using visual analogue scales.


Tuberculosis chemotherapy: reminiscences of early clinical trials.


Introduction of para-amino-salicylic acid and streptomycin in the treatment of tuberculosis. Recollections of the last 25 years.


The twenty-fifth anniversary of para-amino-salicylic acid and streptomycin.


Tuberculosis chemotherapy: reminiscence of in vivo research.


Hemodynamic study by biatrial dye-dilution method after complete correction of tetralogy of Fallot.


Clinical and experimental studies on acute intestinal obstructions with special reference to the cause of death.


The biological properties of silicon compounds.


Cephalosporins.

Cephalosporins.


Psychosocial factors in essential hypertension. Recent epidemiologic and animal experimental evidence.


The liver in acute amebic colitis.

The liver in acute amebic colitis.


Severe electrical burns: a review and analysis of six cases.


Treatment of contaminated surgical wounds with a topical antibiotic: a double-blind study of 240 patients.


Development of methods for the determination of magnesium.


28-Mg studies in magnesium-deficient animals.


Clinical experience with Ibuprofen in the treatment of rheumatoid arthritis.


Suggested role of respiration in bacterial DNA replication.


Loss of "galactose permease" and galactose sensitivity of E. coli associated with mutation in lac operon.


Independent initiation of translation of two bacteriophage f2 proteins.


Alteration of membrane proteins in a chlorate-resistant mutant of Escherichia coli.


Sodium iodide density gradients for the preparative buoyant density separations of DNA mixtures.


Remarkable homology about the disulfide bridges of a trypsin-like enzyme from Streptomyces griseus.


Human liver mitochondrial monoamine oxidase. II. Determinants of substrate and inhibitor specificities.


Specificity of aminoacyl transfer ribonucleic acid synthetases from Escherichia coli K12.


Studies on the catalytic mechanism of Escherichia coli succinic thiokinase.


The side-chain specificity of pepsin.

The side-chain specificity of pepsin.


Comparison of aspirin and dextropropoxyphene-with-aspirin as analgesics in rheumatoid arthritis.


Anaemia in general practice: controlled-release ferrous sulphate and vitamin C compared with ferrous sulphate BP.


Lymphocyte kinetics in chronic lymphocytic leukaemia (CLL) studied by ECIB.


The value of isotopic labelling studies in the treatment of chronic lymphocytic leukaemia by ECIB.


Preoperative ECIB in human renal transplantation.


Infectivity tests in syphilis.

Infectivity tests in syphilis.


Income tax.

Income tax.


Rehabilitation.

Rehabilitation.


UCLA school of medicine. An historical vignette.


The Bluebirds who went over.

The Bluebirds who went over.


Surgery for coronary occlusive disease.

Surgery for coronary occlusive disease.


Immunology of 2-acetylaminofluorene-induced rat mammary adenocarcinomas.


Mitochondrial DNA: physicochemical properties, replication, and genetic function.


Metabolism of enucleated cells.

Metabolism of enucleated cells.


The role of anesthesia in obstetric mortality.


Stereological principles for morphometry in electron microscopic cytology.


A new model for the living cell: a summary of the theory and recent experimental evidence in its support.


The therapeutic efficacy of Symmetrel (amantadine hydrochloride) in naturally occurring influenza A2 respiratoy illness.


Studies on siomycin. 3. Structural features of siomycin A.


Chronic allograft rejection in Lumbricus terrestris.


Mycoplasma pneumoniae in families--a therapeutic study.


Effects of heat selection on toxigenicity, cultural properties, and antigenic structures of clostridia.


Growth of a drug-resistant strain of Mycobacterium bovis (BCG) in normal and immunized mice.


Clinical investigation of new antimicrobial agents.


R factors.

R factors.


The diagnosis and treatment of portal hypertension.


Effect of bone marrow graft on the susceptibility of mice to Friend leukemia virus.


Experimental concurrence of pemphigus-like autoantibodies and bullous-like lesions. A preliminary report.


Common components of the spontaneous EEG and the evoked potential in the cortex.


Radiorespirometry.

Radiorespirometry.


The determination of collagen and elastin.


In memoriam. Martin C. Rosenthal, M.D. 1922-1969.


Phosphorimetry as an analytical approach in biochemistry.


Interpretation of DNA-RNA hybridization data.


Determination of beta-glucuronidases.

Determination of beta-glucuronidases.


Experience of carriers of Medicare.

Experience of carriers of Medicare.


Benign familial hematuria.

Benign familial hematuria.


Ulceration of oral and gastric mucosa produced by stress in rats.


Effects of gastrin on acid and pepsin secretion in pylorus-ligated rats.


The possible role of phospholipase A in the pathogenesis of acute pancreatitis.


Clinical aspects of the gastrointestinal hormones secretin and cholecystokinin.


Effect of diversion of bile and pancreatic juice on pentagastrin-produced duodenal ulcers in cats.


Prophylactic and curative action of Trasylol in pancreatitis. A double-blind trial.


The relation between radiological changes and clinical state in ulcerative colitis.


Experimental pyelonephritis. XV. Increased susceptibility to E. coli infection in old rats.


Grover F. Powers. In memoriam.

Grover F. Powers. In memoriam.


On the necessity of programming psychotherapy.


Inhibition of aminoimidazole ribotide biosynthesis in Salmonella typhimurium by aminotriazole.


How a musical gift modifies the personality of teenagers.


Music therapy with adolescents.

Music therapy with adolescents.


The game of checkers as a diagnostic and therapeutic tool in child psychotherapy.


From total isolation to social communication. Treatment of a case of early infantile austism.


Temporal and cytological aspects of fertilization and early development in the guinea pig, Cavia porcellus.


The pathophysiological morphology of the pigment epithelium and its importance for retinal structures and functions.


Breath-holding and the sensations due to chemical and mechanical stimuli to breathing.


A comparison of erythromycin, novobiocin, tetracycline and a novobiocin-tetracycline combination in purulent exacerbations of chronic bronchitis.


Theory and practice of colour vision testing: a review: 2.


Chest physiotherapy: a physiological assessment during intermittent positive pressure ventilation in respiratory failure.


Effects in man and rabbits of inhalation of cotton dust or extracts and purified endotoxins.


Effect of pH on the proteolysis of ovalbumin by pepsin and dephosphorylated pepsin.


Comparative effects of vinblastine and procarbazine in advanced Hodgkin's disease.


Vaginal discharge in puberty. A survey of 1000 adolescents.


Methylamphetamine hydrochloride (methedrine) in enuresis.


EBV-associated serological patterns in a Burkitt lymphoma patient during regression and recurrence.


Studies on Murine Sarcoma Virus: antigenic characterization of Murine Sarcoma Virus induced tumor cells.


Electron microscopy of murine SJL-J disease.


Studies on the mechanism of action of gougerotin. I. Enhancement of polyphenylalanine synthesis by gougerotin.


Studies on the mechanism of action of gougerotin. II. Effect of various factors on gougerotin action.


Studies on the mechanism of action of gougerotin. 3. Enhancement of enzymatic binding of phenylalanyl-tRNA to ribosomes by gougerotin.


In appreciation: Lawrence Kubie.

In appreciation: Lawrence Kubie.


In honor of Lawrence Kubie.

In honor of Lawrence Kubie.


Bibliography: Lawrence Kubie.

Bibliography: Lawrence Kubie.


Charles H. Liebermann, M.D. An early Russian-born physician of Washington, D.C.


An analysis of the central projection by the evoked potentials produced on stimulation of the vestibular nerve branches.


Edward Gibbon's hydrocele.

Edward Gibbon's hydrocele.


Old hospitals. Ospedale Fatebenefratelli, Rome.


The effect of dipyridamole on increased levels of platelet adhesiveness. Report of a controlled clinical trial.


History of ophthalmology in St. Louis. I.


Admission laboratory test batteries in diabetes mellitus.


Investigations on the sensitivity of isolated strains of Shigella flexneri 2a from mass outbreaks of dysentery to colicins of the Shigella sonnei.


Immunological principles of donor selection for human cardiac transplantation.


Cardiac transplantation.

Cardiac transplantation.


Preservation of the heart.

Preservation of the heart.


Selection of recipients for cardiac transplantation.


Problems in cardiac transplantation from the cardiologist's viewpoint.


The diagnosis of rejection in human heart transplantation.


A new approach to the treatment of rejection: experience with the third human-to-human heart transplantation performed in Cape Town.


Abstracted from a biographical sketch of Edward Glover.


Electrophysiological correlates of behaviour.


Isolation of L-forms from clinical material.


Differentiation of haemophilus species using satellite methods.


Solitary squamous cell papilloma of bronchial origin.


American Academy of Optometry. New members.


Use of acrylic external splint after mandibular resection.


Interim report on immediate mandibular repair.


The versatile deltopectoral skin flap in reconstruction about the head and neck.


Tumbler flap for repair of large defects of the jaw.


Extended shoulder flap and its use in reconstruction of defects of the head and neck.


Cervical island skin flap repair of oral and pharyngeal defects in the composite operation for cancer.


In vitro spread of hog cholera viral infection from cell to cell: demonstration of viral antigen in dividing cells.


In vitro spread of hog cholera vira infection from cell to cell: demonstration of viral antigen in cytoplasmic bridges.


Calvin Jackson Dillaha, MD.--1924 to 1969.


Robert A. Pommerening, MD.--1916 to 1968.


Electrical impedance method for localizing brain structures.


Fluorescent antibody staining of Neisseria, Streptococcus and Veillonella in frozen sections of human dental plaque.


The effect of fixation on the autoradiographic grain count.


Ear damage from exposure to rock and roll music.


Composite grafts in nasal surgery.

Composite grafts in nasal surgery.


Nasopharyngeal syphilis with blindness.

Nasopharyngeal syphilis with blindness.


Johannes Kessel and the history of endaural surgery.


John McCrae: pathologist, poet, soldier, a man among men, 1872-1918.


Walter Reed, M.D.

Walter Reed, M.D.


The chemistry and structure of basement membranes.


Mandrax and its constituents in pre-anaesthetic medication.


Treatment of respiratory failure due to chronic lung disease by intermittent positive pressure ventilation.


Nitrazepam in premedication.

Nitrazepam in premedication.


The prevention of postoperative vomiting after abortion: metoclopramide.


Leprosy in England.

Leprosy in England.


Adverse effect on bacteria of peritoneal dialysis solutions that contain acetate. Peritoneal dialysis solutions which contained 43 mEq per litre of acetate had a greater antibacterial effect than those containing lactate. Bacteria were isolated from 15 separate clinical infections, each caused by Escherichia coli, Pseudomonas sp., or Staphylo-coccus aureus. Incubation in the dialysate made with acetate substantially reduced the number of viable organisms from all but one of the 45 isolates. It is suggested that solutions made with acetate may provide greater protection from peritonitis.


Recent trends in malaria in the United States.


Renal and hematologic complications of acute falciparum malaria in Vietnam.


Complications of falciparum malaria.

Complications of falciparum malaria.


Sixteen points concerning cadaver organ transplantation.


Albertini's advice to Morgagni concerning the acute abdomen.


Malaria eradication at the crossroads.

Malaria eradication at the crossroads.


Unconsidered trifles. No. 1.

Unconsidered trifles. No. 1.


Progress in disseminated intravascular coagulation. II.


Evolution of cesarean hysterectomy.

Evolution of cesarean hysterectomy.


Role of the hypothalamus in menstrual disorders.


Hormonal patterns and interactions in the normal menstrual cycle.


Discovery of the pulmonary circulation.

Discovery of the pulmonary circulation.


Intracardiac ascorbic acid dilution curves: improved technique for the detection of left-to-right shunts.


Salmonella antagonists and salmonella enrichment media.


Evaluation studies resulting in the standardization of the bacterial inhibition assay for blood phenylalanine.


Immunological studies on mouse mammary tumors. I. Induction of resistance to tumor isograft in C3H/He mice.


In vitro demonstration of tumor-specific antigens in spontaneous mammary tumors of mice.


Quantitative studies on the malignant transformation of mouse prostate cells by carcinogenic hydrocarbons in vitro.


Radiosensitivity and growth of Friend leukemia virus studied with the spleen focus assay method.


The history and development of The National Leprosarium in the United States.


Ontario's Queen's University started as a church school.


Environmental appraisal-particulate matter, oxides of sulfur, and sulfuric acid.


Environmental appraisal: oxidants, hydrocarbons, and oxides of nitrogen.


An epidemiological appraisal of the effects of ambient air on health: particulates and oxides of sulfur.


Letter to the editor. Bur fracture with air-driven contra-angles.


A brief history of the NAMRU-3 Medical Zoology program.


Ultrastructure of the rabbit neural lobe after freeze-etching.


Influence of oxytocin on transport of spermatozoa in ovariectomized female rabbits.


Esmond R. Long, M.D., Ph.D.

Esmond R. Long, M.D., Ph.D.


Host conversion by prophage lambda in a recombination-deficient mutant of Escherichia coli.


Obituary. Cyril I. Crowther, 1895-1968.

Obituary. Cyril I. Crowther, 1895-1968.


Interconversion of rec+ and rec- phenotype in lambda lysogens of Escherichia coli.


Olaf K. Skinsnes, new editor of the journal.


Azathioprine in the management of rheumatoid arthritis.


Processing of throat cultures in the physician's office.


The structural and functional diversity of Adenovirus capsid components.


Influence of electrical current on renal allograft.


A comparison of pulsatile and nonpulsatile pumping for ex vivo renal perfusion.


Studies on human gastric intrinsic factor. II. In vitr assay of human gastric juice and purified human intrinsic factor for intrinsic factor activity.


Frederik Ruysch (1638-1731). Curator of anatomical specimens.


Why is the doctor in the Merry Wives of Windsor called Caius?


Dominique Anel and the small lachrymal syringe.


Some aspects of epidemics and German art about 1500.


The collateral sciences in the work of Golding Bird (1814-1854).


Cell chemistry in Miescher's day.

Cell chemistry in Miescher's day.


Early specialization in ancient Egyptian medicine and its possible relation to an archetypal image of the human organism.


Dermatological writings of ancient India.


Salmonella isolations from foodstuffs in the East Sepik District of the Territory of Papua and New Guinea employing an elevated temperature technique.


General paralysis in Victoria, Australia: historical study.


Criteria for utilization review.

Criteria for utilization review.


From capitol hill. Recommendations of first annual report on medicare.


Blood culture.

Blood culture.


Comparison ofthe effect of histamine and pentagastrin on gastric secretion in ulcer patients.


The effect of 1-hyoscyamine on gastric secretion of acid and pepsin in man.


Porphyria and King George 3d.

Porphyria and King George 3d.


Changing sensitivity of the pubertal gonadal hypothalamic feedback mechanism in man. Clomiphene citrate in doses which stimulate gonadotropin production in the adult suppresses urinary follicle stimulating hormone (FSH) excretion and plasma testosterone concentration in prepubertal children. Such results indicate that feedback between gonad and hypothalamus is operative and highly sensitive in prepubertal humans. Puberty in man, as in the rat, is accompanied by a decrease in the sensitivity of the feedback mechanism.


No more abdominal wound dehiscences.

No more abdominal wound dehiscences.


Hodgkin's sarcoma of the small bowel.

Hodgkin's sarcoma of the small bowel.


Aplastic anemia: case report of an apparent response to the transplantation of rib marrow.


Nerve regeneration after replantation of severed arms.


Psychotropic drugs and induced hostility.


Survival of allografts after hepatic portal venous administration of specific transplantation antigen.


The management of closed chest injuries.


Chest injuries.

Chest injuries.


Surgical aspects of clinical liver transplantation in 14 cases.


The recognition of atrophic gastritis.

The recognition of atrophic gastritis.


A day-case procedure for the cure of third-degree haemorrhoids.


A single-layer intestinal anastomosis.

A single-layer intestinal anastomosis.


Electron microscope studies of somatotrophs of rat pituitary after injection of purified growth hormone releasing factor (GRF).


The structure of the major cell processes of isolated BHK21 fibroblasts.


Serotype transformation in Paramecium aurelia: antigen synthesis after a temperature change.


Changes produced by cobra venom cytotoxin on the morphology of Yoshida sarcoma cells.


Prof. Dr. Jan Wolf, 13. 5. 1894.

Prof. Dr. Jan Wolf, 13. 5. 1894.


Diabetes in India--retrospect and prospect.


Offspring of two diabetic parents: differential serum insulin responses to intravenous glucose and tolbutamide.


Osseous coagulum for bone induction.

Osseous coagulum for bone induction.


Transfer of responsiveness to hapten conjugates of poly-L-lysine and of a copolymer of L-glutamic acid and L-lysine to lethally irradiated nonresponder guinea pigs by bone marrow or lymph node and spleen cells from responder guinea pigs. Hartley guinea pigs genetically unresponsive to hapten-PLL (poly-L-lysine) conjugates were lethally irradiated and given allogeneic bone marrow from Hartley responder animals. Many of the animals died of graft versus host disease before their response to 2,4-dinitrophenyl-PLL (DNP-PLL) could be measured. The immune response of the surviving recipient animals was evaluated by anti-DNP antibody production, development of delayed hypersensitivity to DNP-poly-L-lysine, as well as by lymph node cell stimulation in vitro by this antigen. 12 of 14 recipient animals thus treated made an immune response as measured by 2 of the 3 parameters. Strain 13 guinea pigs, genetically unable to respond immunologically to DNP-PLL and to DNP-GL (2,4-dinitrophenyl-L-glutamic acid L-lysine copolymer) were lethally irradiated and given bone marrow from (2 x 13) F(1) responder animals or strain 13 bone marrow and (2 x 13) F(1) lymph node and spleen cells. A high proportion of the animals survived this procedure; no evidence of graft versus host disease was observed. Three of three strain 13 animals irradiated and, given strain 13 bone marrow and (2 x 13) F(1) lymph node and spleen, and then immunized with DNP-PL, made a specific immune response. 7 of 10 irradiated strain 13 animals given strain 13 bone marrow and (2 x 13) F(1) lymph node and spleen made an immune response to DNP-GL. However, only one of six irradiated strain 13 animals made a vigorous immune response to DNP-GL after reconstitution with (2 x 13) F(1) bone marrow alone. The ability to transfer the immune response to PLL antigens from responder to nonresponder animals demonstrates unequivocally that the defect in the non-responder animals is immunological rather than due to some other type of non-immunological mechanism. The bone marrow contains all the immunological cells necessary for the expression of the PLL gene. However, the finding that (2 x 13) F(1) lymph node and spleen cells were more effective than (2 x 13)F(1) bone marrow cell populations (known to be a rich source of monocyte precursors) suggests that the cells in which the PLL gene function is expressed may be lymphocytes rather than monocytes and macrophages.


The grafting of newly formed autogenous bone in the treatment of osseous defects.


Periodontal disease in sheep. 1. Review of the literature.


Gold Medal Award. Dr. M. K. Hine's acceptance speech.


Estimation of spermatozoa numbers using a micropore filtration technique.


Changing pharyngeal bacterial flora of hospitalized patients. Emergence of gram-negative bacilli.


Biology and pathogenicity of microbial spheroplasts and l-forms.


William Dameshek, M.D. (1900-1969).

William Dameshek, M.D. (1900-1969).


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 48-1969.


Antidiuretic hormone and evaporative weight loss during heat stress.


Regulation of sugar transport in isolated bacterial membrane preparations from Escherichia coli. The experiments presented in this paper demonstrate that glucose transport via the phosphoenolpyruvate-phosphotransferase system as studied in isolated E. coli membrane preparations is subject to regulation by sugar-P's. Glucose transport in these preparations is inhibited by glucose-6-P, glucose-1-P, and, to a lesser extent, by other P-esters. There appear to be two inhibitory sites, one specific for glucose-1-P and related sugar-1-P's and the other specific for glucose-6-P and related sugar-6-P's. The inhibition by these sugar-P's is noncompetitive, and the inhibitory sites are separate, subject to independent control, and apparently are accessible from outside the membrane. Furthermore, glucose-6-P is able to reverse partially inhibition of glucose transport by glucose-1-P and vice versa. Preliminary evidence is presented indicating that glucose-1-P may play a central role in the regulation of sugar transport in general, by virtue of its ability to inhibit selectively the transport of sugars other than glucose.


Dysfunctional sperm production in Drosophila melanogaster males homozygous for the segregation distorter elements. Drosophila males heterozygous for the segregation distorter chromosome show a reduction in fecundity which is correlated with the degree of distortion of their segregation ratio. When males are made homozygous for the segregation distorter elements, their fecundity is lowered to just that extent expected if each SD were independently causing the sperms carrying the other to dysfunction. In three cases tested, Sd Ac/Ac, Sd Ac/Sd Ac, and Sd Ac St/Sd Ac St, the fecundity of the males is consistent with the dysfunction model, whereas the females are normal. The Sd Ac St/Sd Ac St males are almost completely sterile. They do produce sperms, however, which are motile and which look morphologically normal in the phase contrast microscope. They are transferred to the female during copulation and are stored in apparently normal numbers in the seminal receptacle and spermathecae.


Functional interdependence of ribosomal components of Escherichia coli. Ribosomes are made up of parts that interact so strongly that a mutation in one of them can mask the effect of mutation in another. For example, when a mutation to neomycin resistance, which is a ribosome mutation, is introduced into cells carrying a ribosome mutation to spectinomycin resistance, some of the doubly mutant strains were phenotypically sensitive to spectinomycin, even though the mutation to spectinomycin resistance is still intact and recoverable in appropriate crosses. The neomycin mutant alleles that cause masking were shown by genetic tests to be in an identified locus that affects ribosomes. Protein synthesis in cell-free extracts of a double mutant strain was as sensitive to the action of spectinomycin as was the extract of the doubly sensitive parental strain. Thus, the masking effect of neomycin mutations on the spectinomycin mutation is exerted at the level of the ribosomes.We conclude that the genetic analysis of an organelle like the ribosome is likely to be severely complicated by pleiotropic effects and by interactions among its component parts and that the ribosomal binding sites for spectinomycin and neomycin are partially interdependent. These results suggest that the function of the ribosome requires a very precise conformation of all its elements, some of which are interdependent. Modification in one element can thus alter the function of another or even render the entire structure nonfunctional.


Interferon synthesis in x-irradiated animals. IV. Donor-type serum interferons in rat-to-mouse radiation chimeras injected with Newcastle disease virus. C(3)H/He mice were exposed to total-body X-irradiation of 1000 roentgens and received thereafter 10(7) xenogeneic Wistar rat marrow cells intravenously. In these rat-to-mouse chimeras, serum interferon-producing capacity upon injection of Newcastle disease virus was examined four weeks after grafting. Normal levels of circulating interferon were produced. The interferon, however, had the species specificity of rat interferon, being 20 times more active in rat embryo fibroblasts than in mouse embryo fibroblasts. Moreover, it behaved like rat interferon when filtered on Sephadex G-100 dextran gel, displaying one peak of activity in the 90,000 molecular-weight range and two incompletely separated peaks of 32,000 and 24,000, respectively, in the 30,000 molecular-weight region. The fact that the interferon is of the donor type in rat-to-mouse chimeras permits us to conclude that circulating interferon induced by New-castle disease virus is made in bone-marrow-derived cells.


Evidence for multiple growing points on the genome of rapidly growing E. coli B-r. Synchronized cultures of rapidly growing E. coli B/r cells were starved for a required amino acid at various cell ages to allow ongoing chromosome replication to be completed without initiation of new replication cycles. It has been found that when such synchronized cultures are exposed to the mutagen nitrosoguanidine, genetic markers just in the process of replication show a markedly higher mutation rate than markers elsewhere on the chromosome. The number of growing points on the chromosome at each cell age can then be determined by observing the nitrosoguanidine-induced mutation rates for specific genetic markers on the genome. These experiments indicate that there exist multiple growing points on the genome for about ten minutes during the life cycle when the cells are growing with a doubling time of 28 minutes.


Polypeptide chain initiation in E. coli: studies on the function of initiation factor F1. The requirement of initiation factors F(1) (highly purified) and F(2) (electrophoretically homogeneous) for ribosomal binding of N-formylmethionyl transfer RNA (fMet approximately tRNA) at low Mg(2+) concentration (3.5 mM), with the trinucleoside diphosphate ApUpG as messenger, was studied under various experimental conditions with 30S + 50S ribosomes and with 30S subunits alone. The results were qualitatively the same in both cases but the amount of binding was two to three times higher when both 30S and 50S subunits were present. Although there was a virtually absolute requirement for F(2) in all cases, considerable binding occurred at 0 degrees in the absence of added F(1). F(1) addition stimulated binding up to twofold under these conditions. However, at 25 degrees , the temperature at which the reaction is usually carried out, there was very little binding with F(2) alone and addition of F(1) stimulated the reaction five- to sixfold. Contrary to current belief, the GTP analog 5'-guanylyldiphosphonate (GMP-PCP) cannot replace GTP in the binding reaction. In particular, there was but little stimulation of binding (about 1.5-fold) by addition of F(1) to F(2)-containing samples when GMP-PCP was used. In marked contrast, binding was stimulated up to sevenfold by addition of F(1) when GTP was substituted for the analog. Under these conditions, there was an ApUpG and F(1)-dependent hydrolysis of GTP. This is observable with 30S subunits alone and can hardly be related to the occurrence of translocation. The results may be interpreted to mean that a complex relatively stable at 0 degrees , but less stable at 25 degrees , is formed upon addition of F(2) alone. Conversion of the less stable to the more stable form of complex is made possible by addition of F(1). This is accompanied or mediated by cleavage of GTP.


A lipid requirement for induction of lactose transport in Escherichia coli. The rate of derepressed synthesis of a membrane protein required for lactose transport (M protein) by Escherichia coli is increased in response to increased gene dosage to the same extent as the rates of synthesis of beta-galactosidase and galactoside acetylase. However, elevated gene dosage does not increase beta-galactoside transport to the same extent that it increases synthesis of M protein and of the soluble proteins of the lac operon. Though the factor or factors other than M protein which limit induction of the transport system at high levels of lac operon expression have not been identified, studies with Escherichia coli mutants blocked in the synthesis of unsaturated fatty acids indicate that unsaturated fatty acids must be supplied during the course of induction of the lac operon to permit synthesis of a functional lactose transport system, but not of beta-galactosidase or galactoside acetylase.


The enzymatic termination of polydeoxynucleotides by 2',3'-dideoxyadenosine triphosphate. The nucleoside 2',3'-dideoxyadenosine is lethal to E. coli and blocks DNA synthesis irreversibly. The hypothesis that a derived dideoxynucleoside triphosphate is incorporated terminally into the cellular DNA has been tested in an in vitro system. The triphosphate of dideoxyadenosine was synthesized and shown to inhibit the in vitro synthesis of DNA by purified E. coli DNA polymerase. The kinetics of inhibition of nucleotide incorporation and pyrophosphate exchange were studied. Early in synthesis the dideoxynucleotide is a competitive inhibitor of the enzyme. Subsequently, synthesis is almost completely arrested.Radioactive dideoxyadenosine triphosphate was prepared. The compound was shown to be incorporated enzymatically into dAT copolymer to the extent of about one molecule per molecule of template. It is released from such templates by DNA polymerase at less than 1 per cent of the rate of release of other natural nucleotides. The label is released by snake venom phosphodiesterase far more rapidly than total nucleotides. This nucleoside triphosphate has thus been shown to be a competitive inhibitor of DNA polymerase and a terminator of polydeoxynucleotide chains.


Cytokinins: distribution in transfer RNA species of Escherichia coli. This distribution of cytokinin activity in tRNA species of Escherichia coli has been determined. Cytokinin activity was restricted to tRNA species recognizing codons with the initial letter U. The following have been shown to contain a cytokinin: tRNA(Phe), tRNA(Leu) UUG, tRNA(Ser)UC(G) (A), tRNA(Tyr), and tRNA(Try). tRNA(Cys) was present in fractions with cytokinin activity but was not sufficiently pure to prove it to be active. One tRNA(Ser) UC(C) (U) species was inactive. All major tRNA species recognizing condons with initial letters other than U were devoid of cytokinin activity in the tobacco bioassay. The significance of these findings is discussed as providing a possible mechanism of quantitative modulation at the translation stage of gene-controlled protein biosynthesis.


Sulphamethoxazole-trimethoprim therapy in urinary tract infection with reference to its haematological effects.


Autologous transfusion.

Autologous transfusion.


The differentiation of cerebral dendrites: A study of the post-migratory neuroblast in the medial nucleus of the trapezoid body.


The growth of dendrites in the mammalian brain.


Capillary endothelial cells of the anterior pituitary should be excluded from the reticulo-endothelial system. Light and electron microscopic observations on rabbits and rats.


The effect of vaccination against measles on the white blood picture and the alkaline phosphatase activity of neutrophil leukocytes.


The chemical and biological properties of heated and oxidized fats.


Control of plasma and liver triglyceride kinetics by carbohydrate metabolism and insulin.


Aortic insufficiency; "original" descriptions.


Orthotopic cardiac prosthesis for two-staged cardiac replacement.


Bibliography and notes of some contributions of Joseph E. Milgram, M.D.


Identification and arrangement of coxsackievirus A1 in muscles of newborn mice.


Extra-hepatic derivation of Kupffer cells during oestrogenic stimulation of parabiosed mice.


Orthopaedic giants I have known.

Orthopaedic giants I have known.


Recent progress in the chemistry, crystal chemistry and structure of the apatites.


Chemical characterization, spatial distribution and function of a lipoprotein (murein-lipoprotein) of the E. coli cell wall. The specific effect of trypsin on the membrane structure.


On the extraction of ribonucleic acid with template activity from barley embryos using diethyl pyrocarbonate as nuclease inhibitor.


Immunochemistry of R lipopolysaccharides of Escherichia coli. Different core regions in the lipopolysaccharides of O group 8.


Synchronization of Escherichia coli in a chemostat by periodic phosphate feeding.


Control dynamics of beta-galactosidase in relation to the bacterial cell cycle.


On the specificity of the reduction of transfer ribonucleic acids with sodium borohydride.


On the role of S-adenoxylmethionine in the vitamin B12 dependent methionine biosynthesis.


The coding properties of multiple tRNA for valine and leucine in hemoglobin synthesis.


Puromycin sensitivity of ribosomal label after incorporation of 14C-labelled amino acids into isolated mitochondria from Neurospora crassa.


Synthetic ribonuclease and the future.

Synthetic ribonuclease and the future.


Clinical significance of caeruloplasmin.


Intrinsic factor, nonintrinsic factor vitamin B12 binder, and pepsinogen secretion in normal subjects. Quantification using intragastric neutralization and inorganic phosphate as a marker.


The geographical pathology of liver disease in man.


Simultaneous glutaraldehyde-osmium tetroxide fixation with postosmication. An improved fixation procedure for electron microscopy of plant and animal cells.


A small haemagglutinating porcine DNA virus. I. Isolation and properties.


The microcirculation of the transplanted heart.


Organ viability with hypothermia.

Organ viability with hypothermia.


Prolonged survival of rat skin allografts treated by prolonged hypothermia. A preliminary report.


Host-controlled restriction and modification of Salmonella typhimurium.


Establishment of a malignant cell line derived from human adenovirus type 12-induced hamster tumor in tissue culture.


Electron microscopic study of the so-called "separating zone" in the striated duct cell of the parotid gland.


Hyperinsulinism in dogs with neoplasia of the pancreatic islets. A clinical, pathologic, and ultrastructural study.


Medical care: as costs soar, support grows for major reform.


Ischemic necrosis of tibialis anterior muscle in burn patients: report of three cases.


Physiologic evaluation of canine lung allografts from cadaver donors.


Crush injuries of the chest. A follow-up study of patients treated in an artificial ventilation unit.


Studies on protoplasts of Geotrichum candidum: Mechanism of formation of protoplasts and their physical and morphological properties.


Preservatives in eye drops.

Preservatives in eye drops.


Mucosubstances of t acini of the human lacrimal gland (orbital part). II. Biochemical identification.


Senile exfoliation (pseudo-exfoliation, fibrillopathia epitheliocapsularis) of the lens capsule in a postmortem material. Microscopic investigation of 100 eyes.


Embryogenesis in cestodes.

Embryogenesis in cestodes.


Epithelial cysts in the conjunctiva.

Epithelial cysts in the conjunctiva.


The structure and composition of the helminth cuticle.


Experimental studies on Entamoeba with reference to speciation.


Dynamics of parasitic equilibrium in cotton rat filariasis.


Some tissue reactions to the nematode parasities of animals.


Acute toxoplasmosis complicating leukemia. Diagnosis by bone marrow aspiration.


Clonorchis and clonorchiasis.

Clonorchis and clonorchiasis.


Aortic plaque morphology in relation to coronary artery disease.


Symposium: A sesquicentennial study of Daniel Drake and the results of his theories on medical education. Revelations.


Influence of catecholamines on pepsinogen production.


Autoimmune responses to human tumour antigens.


Sedative properties of simple analgesics. 1. An attempt has been made to assess under double blind conditions the sedative action of phenacetin, paracetamol, and aspirin by testing their ability to prolong sleep in the face of a rapidly filling bladder.2. The volume in the bladder on awakening was independent of the rate of urine formation.3. Although phenacetin prolonged sleep there was no corresponding increase in urine volume on awakening. Apparently phenacetin sensitized the bladder to the distending volume and reduced the rate of urine formation. It was unnecessary to postulate sedative action to explain the results.4. Paracetamol had no effect on the mean sleep interval or mean urine volume although the drug was not totally inactive since it increased the variance of the results for sleep interval and urine volume.5. Aspirin prolonged sleep interval, but this effect would be explained if it were an antidiuretic because there was no increase in urine volume on awakening.6. Apparently no sedative or hypnotic has been shown to increase the urine volume on awakening under similar conditions.


"Fenny Poppers". A quaint celebration for Dr. Thomas Willis.


Verbal behaviour changes with depression treatment.


Late failure in cadaveric renal allografts. Sixteen patients with renal cadaveric allografts who have survived for one year or longer are reported. The patients were analyzed from the standpoint of incidence, quantity and course of proteinuria in relation to renal function and the nature of the original disease.This analysis shows that proteinuria is progressive and is accompanied by a decline in renal function when the original disease is of an immune nature. This was not so in patients with non-immune original disease. These findings suggest that recurrence of original disease plays an important role in late failure of cadaveric renal allografts.


Mental illness in the puerperium.

Mental illness in the puerperium.


The interaction of diabetes and obesity on the regulation of fat mobilization in man.


Arteriovenous crossings on the chorial surface of the human placenta in abnormal pregnancy and development.


Arteriovenous dissociation on the chorial surface of the human placenta in abnormal states of pregnancy and development.


Primary division ratio of umbilical arteries and vein of the human placenta in abnormal states of pregnancy and development.


High secretory activity in the pancreatic B cells of diabetic strain of the Japanese mouse.


Hypothalamic and cerebral cortical inhibitors of a melanocyte-stimulating substance secreted by the pars distalis of the frog pituitary gland.


Protein synthesis in Escherichia coli after gamma-irradiation in the presence of alkali halides.


Polyamines and protein synthesis. I. The effect of polyamines on cell free polyphenylalanine synthesis in Escherichia coli.


Template activity of chromatins isolated from regenerating rat liver.


Dethiobiotin synthesis from 7,8-diaminolargonic acid in cell-free extracts of a biotin auxotroph of Escherichia coli K-12.


Evidence for enzyme-bound beta-aspartyl phosphate in the aspartokinase reaction.


The amino acid sequence of peptide (1-24) of rat and human serum albumins.


Acyl carrier protein. XII. Synthesis and turnover of the prosthetic group of acyl carrier protein in vivo.


Medicare hold the line policy (anatomy of a decision).


Sociological and psychological factors associated with hearing loss.


Community psychiatry in the army. History, practice, and applications to civilian psychiatry.


Hippocrates (460-375 BC).

Hippocrates (460-375 BC).


Dr. James H. Blake. Third Mayor of Washington, D. C.


Liver transplant at children's hospital--a case report.


Charles Stanley White, Sr., M. D. (1877-1969).


Home dialysis.

Home dialysis.


Traumatic rupture of the spleen. A review.


Somatic growth of children in the United States.


Comprehensive health care planning. New Effort of redirected energy.


Total dose iron infusion.

Total dose iron infusion.


Defective vitamin B 12 metabolism in the human being: changes in methionine and methylmalonic acid excretion.


Mechanisms of copper absorption in the chick.


The modern Kelly plication.

The modern Kelly plication.


The role of sodium in non-electrolyte transport across animal cell membranes.


The insect vector as transmitter of disease.


Subaquean construction at the St. Louis Bridge initiates caisson disease.


John Van Prohaska. 1904-1969.

John Van Prohaska. 1904-1969.


Stereotaxic surgery using a television guidance system. I. Thalamotomy.


Immunological aspects of carcinogenesis by deoxyribonucleic acid tumor viruses.


Monoamine oxidase in sympathetic ganglia of the cat.


Advances in pediatric ophthalmology.

Advances in pediatric ophthalmology.


Some operant conditioning techniques and their use in schools for the deaf.


The dilemma of the rejecting heart transplant.


Personal experience in the extracorporeal preservation of dog kidney.


Fore-'n-aft triangle formula for rapid estimation of area. Dye dilution curve.


The hydrogen ion and pulmonary vasomotricity.


Hepatic dysfunction associated with renal transplantion.


Catheterization, delivery, and puerperal bacteriuria.


Mushroom transcorneal keratoprosthesis (bolt and nut).


Skin grafting in the treatment of fistula in ano (38 cases).


Present status of prosthokeratoplasty.

Present status of prosthokeratoplasty.


A holistic (Horney) approach to the psychoses: the schizophrenias. I. Sociocultural, developmental and psychogenetic factors.


Hyperkalemia and cardiovascular collapse following administration of succinylcholine to the traumatized patient.


The indications for gasserian ganglion block for trigeminal neuralgia.


Acute epiglottitis managed with nebulized epinephrine delivered by IPPB.


Total automation of an antibiotic bioassay.


Escherichia coli ribosomes: recent developments.


Carbohydrate metabolism in microorganisms.


Regulation of enzyme function.

Regulation of enzyme function.


Suture reaction in the human cornea.

Suture reaction in the human cornea.


Mycobacterium fortuitum infection of corneal graft.


Retinal detachment. 360 degree scleral buckling as a primary procedure.


Comparative assessment of vagotomy with pyloroplasty and simple suture in the surgical treatment of perforated duodenal ulcer.


A comparison of sintisone' with prednisolone in the treatment of reversible bronchospasm.


A clinical trial of 'callusolve' in patients with warts.


Viruses in cerebrospinal fluid.

Viruses in cerebrospinal fluid.


Insulin biosynthesis: effects of carbohydrates and related compounds.


The orthopedic service at St. Luke's Hospital, New York City. 1859-1968.


Volar-flap advancement for thumb and finger-tip injuries.


The organization and polymerization of bone and dentin collagens.


Mads Nygaard Smith-PETERSEN AND Norway.

Mads Nygaard Smith-PETERSEN AND Norway.


M.N. SmithPetersen as seen by a colleague.


Treatment of fractures of the tibial shaft.


Marius N. Smith-Petersen from the point of view of a resident.


Fat embolism. A current concept.

Fat embolism. A current concept.


Editorial comment: Dr. Marius N. Smith-Petersen.


Chlormethiazole in alcoholism.

Chlormethiazole in alcoholism.


An industrial medical department over 100 years old. The amazing story of the West German Badische Anilin-& Soda-Fabrik AG.


Antibodies in patients with Burkitt's tumor and leukemia: comparison of two fluorescence tests.


Effects of high-speed drill noise and gunfire on dentists' hearing.


Endosseous implants as fixed bridge abutments.


Squibb ER: Know your suppliers..."the priceless ingredient".


Orthodontic and surgical procedures for correction of severe oral and facial malformation: report of case.


Deans, then and now.

Deans, then and now.


Stereotaxic spinal surgery. A preliminary report.


An infantile diarrhea epidemic. Comparative response to antibiotic therapy.


Localization of stereotaxic lesions in the treatment of Parkinsonism: a clinico-pathological comparison.


Applications of modern electroanalytical techniques to pharmaceutical chemistry.


Renal transplants and renal tumors.

Renal transplants and renal tumors.


Surgical debridement for resistant bacterial endocarditis. A case of antibiotic-refractory Serratia marcescens infection on the tricuspid valve cured by operative excision.


Admiral Lord Nelson's neurological illnesses.


Electrical coupling between myocardial cells.


The uptake, storage, release and metabolism of noradrenaline in sympathetic nerves.


Recent developments on the ultrastructural aspect of adrenergic nerve endings in various experimental conditions.


Doctor Thomas Hodgkin and Sir Moses Montefiore.


Down with plasma. Intracellular chemical pathology studied by analysis of cells of solid tissues, erythrocytes, and leukocytes.


Morphological and cytochemical studies on the synapses in the autonomic nervous system.


Two old friends.

Two old friends.


Phagocytic activity of leukemic myeloblasts.


Clinical experience with selective gastric and total abdominal vagotomy. Special reference to insulin test and postvagotomy diarrhea.


The eye in arthritis.

The eye in arthritis.


Rheumatism treatment centres in Britain--Bath ancient and modern.


Partially deaminated L-asparaginase.

Partially deaminated L-asparaginase.


DNA replication of phage T4 rII mutants without polynucleotide ligase (gene 30).


Formation of the ribosome-G factor-GDP complex in the presence of fusidic acid.


Isolation of cytokinins from tRNA.

Isolation of cytokinins from tRNA.


Leucyl-pepsin a product of hog pepsinogen activation by proteinases of aspergillus oryzae.


Comparative studies on the mechanism of action of lincomycin, streptomycin, and erythromycin.


On the availability of intramitochondrial carbamoylphosphate for the extramitochondrial biosynthesis of pyrimidines.


Early effects of Bdellovibrio infection on the syntheses of protein and RNA of host bacteria.


Congenital endothelial corneal dystrophy. Clinical, pathological, and genetic study.


New implant for drainage in glaucoma. Clinical trial.


Single-stitch operation for senile entropion.


The value of lymphography in malignant reticulosis.


Attenuation of human influenza A viruses. The attenuation of two human influenza A viruses has been carried out, using the selection of inhibitor-resistant strains and multiple passages at low temperatures. A virus related to A2/Tokyo/3/67 was obtained in an inhibitor-resistant form. When this was compared with the inhibitor-sensitive strain in a volunteer trial it was relatively non-pathogenic. The second virus, A2/Hongkong/1/68, was subjected to much longer treatment, but nevertheless remained slightly sensitive to serum inhibitor. When given to volunteers it was less pathogenic than before but attenuation was incomplete. A2/Hongkong/1/68 was also modified by passage at low temperatures. Many of these passages are apparently necessary for full attenuation.All attenuated viruses were infective and antigenic.


George Cheyne's Essay of Health and Long Life.


Topical ampicillin in the appendicectomy wound: report of double-blind trial. One hundred and thirty unselected patients undergoing appendicectomy were treated with topical ampicillin powder or topical placebo powder (lactose) before closing the wound. The postoperative wound infection rates were 3% in the ampicillin-treated group and 24% in the control group, a significant difference. This difference was not influenced by the degree of inflammation in the appendix. No side-effects of treatment were observed.


Citations obtained through the National Library of Medicine's MEDLARS programs.


Medicare and the financing of teaching hospitals.


The human figure drawing test and academic outcome in medical school.


And then there were nine.

And then there were nine.


C.J. Herrick, scholar and humanist: a memorial essay written for his centenary.


The molecular conception of rickets pathogenesis. I. Clinical research.


A firstling of his heart and hand.

A firstling of his heart and hand.


Oswald Theodore Avery and DNA.

Oswald Theodore Avery and DNA.


The country doctor and the specialist--excerpts.


A new tilting disc valve prosthesis.

A new tilting disc valve prosthesis.


Cytologic diagnosis of metastatic myosarcomas.


Characterization of bovine viral diarrhea viruses. IV. Sequential development of BVD viral antigen in cell cultures studied by immunofluorescence.


The linkage between the D-glucosamine units of lipid A isolated from the lipopolysaccharide of Serratia marcescens.


The intracellular pH of Escherichia coli.


Lymphangiography in dermatology.

Lymphangiography in dermatology.


Basic requirements for the international exchange of transplantable organs.


Some current problems in the sero-immunology of trypanosomiasis in relation to the epidemiology and control of the disease. The author draws attention to the need for accurate epidemiological information so that control programmes may be properly orientated and he emphasizes that we are still at a loss in this respect in the case of trypanosomiasis, as we still lack methods to recognize, among the assemblage of natural trypanosome populations with identical morphology, those populations that have the biological capabilities to produce disease in man and his domestic stock.Immunological approaches do, however, show some promise in this respect in that it is possible to relate the antigenic type to particular virulence characteristics, at least in mice. Nomenclature of trypanosome antigenic types requires to be improved and agreed so as to facilitate the integration of the work of different laboratories. Immunological methods have also improved disease survey, and tests such as immunofluorescence, and serum and cerebrospinal fluid IgM estimation, are now available. These tests may be applied conveniently on a large scale and to primitive populations. They powerfully complement the classical parasitological survey methods. Studies on the immunization of animals against trypanosomiasis have not yet yielded any method of practical application but are useful contributions to basic knowledge and have indicated areas in need of special investigation-such as the variety of antigenic types of the main pathogenic trypanosome species circulating in given areas of Africa, the stability of this "spectrum" of antigenic types in time, and the range of distribution in Africa of particular antigenic types.


An electrophysiological approach to drug-receptor mechanisms.


Transatlantic trade in pharmaceuticals during the industrial revolution.


The correspondence of Morgagni and Lancisi on the death of Cleopatra.


Epidemilogy of stillbirths from congenital abnormalities in England and Wales, 1961-1966.


Letters from a surgeon in the Crimean War.


The history of residential services for the mentally handicapped.


A controlled clinical study of metopimazine and perphenazine in treatment of radiation nausea and vomiting.


Macrophage cytophilic antibody in mice. Differentiation between antigen adherence due to these antibodies and opsoni adherence.


Macrophage cytophilic antibodies to tuberculoprotein in rats immunized with Bacillus Calmette Guérin.


Cephalexin: microbiological effects and pharmacologic parameters in man.


Triadic-based family therapy.

Triadic-based family therapy.


Pentapiperide methylsulfate (Quilene). Anticholinergic with antisecretory and antimotility activity on the upper gastrointestinal tract for adjunctive therapy in the management of peptic ulcer.


Immunofluorescence studies on the anatomic distribution of the soluble antigen responsible for the production of nephrotoxic serum nephritis.


Effect of vasopressin infusions on thyroidal radioiodine uptake and serum TSH concentration.


Neurotrophic dependence of the lateral-line sensory organs of the newt, Triturus viridescens.


Sequential arginine and insulin tolerance tests on the same day.


The sterility testing of pharmaceuticals.


Immunosuppression by antigen-associated human serum alpha-one protein.


Physiologic surface-active agents and drug absorption. IV. Effect of pre-micellar concentrations of surfactant on dissolution rate.


The ultrastructure of chloroplast of a brown alga Sphacelaria sp. I. Plastid DNA configuration--the chloroplast genophore.


A fine-structural analysis of larval salivary gland function in Chironomus thummi (Diptera).


The fine structure of a nucleolar constituent.


Extracellular space in the rat brain after fixation with 12 M formaldehyde.


A comparison of methods used to determine motility of strains of Gram-negative bacteria isolated from aqueous pharmaceutical preparations.


The combined effect of 6-azauridine and irradiation in vivo and in vitro. V. Primary and secondary antibody response in mice pretreated with repeated 6-AzUR application and irradiation.


Antiarrhythmic prophylaxis with procainamide in acute myocardial infarction.


Medicine in the ghetto.

Medicine in the ghetto.


Ernesto (Che) Guevara. Physician--revolutionary physician--revolutionary.


Che Guevara: the antihero.

Che Guevara: the antihero.


Macmiror in the treatment of trichomonadosis in women.


Chorionic gonadotropin localization in the albino rat placenta by immunofluoresent staining.


Editorial. Harold Hillenbrand retires: end of an era.


Editorial. The Association's seventieth.


The Martin Dewey Memorial Award.

The Martin Dewey Memorial Award.


Computer-aided differential diagnosis of hematologic diseases.


Protection of stripped enamel surfaces with topical fluoride applications.


Asbestos and health in 1969.

Asbestos and health in 1969.


Zinc metalloenzymes: characteristics and significance in biology and medicine.


The partial gastrectomies for chronic peptic ulcer: Finochietto's modification of the Billroth I operation.


A comparative trial of chlorphenesin and pecilocin in a prison community.


A cross-over trial of chlordiazepoxide-with-amitriptyline and amitriptyline alone.


Carbon dioxide.

Carbon dioxide.


Renal transplantation in the rat.

Renal transplantation in the rat.


Anesthesia and the hypertensive patient.


Awareness during anesthesia.

Awareness during anesthesia.


Body temperature variations during anesthesia.


Clinical questions related to fluids.

Clinical questions related to fluids.


Anesthetic and surgical problems in treating aortofemoral occlusive disease.


Anesthetic problems in carotid endarterectomy.


Common and uncommon problems in anesthesiology. Prologue. Problems--a few glances backward.


Prevention and recognition of surgical renal complications.


Anesthesia for uremic patients.

Anesthesia for uremic patients.


The role of the anesthesiologist in the doctor-patient relationship.


Pituitary surgery for diabetic retinopathy: problems in anesthetic management.


Unusual toxicities of drugs used in anesthetic practice.


Ultrasonic techniques in pelvic cancer.

Ultrasonic techniques in pelvic cancer.


F, Sall S: Radioisotopic evaluation in oncology.


Renal function in gynecologic carcinoma.


Amnioscopy.

Amnioscopy.


Dental realism for Dustin in "Midnight Cowboy".


Aflatoxin in two instalments. II.

Aflatoxin in two instalments. II.


Animal aggression: review of research.

Animal aggression: review of research.


Personality and psychosomatic illness: a selective review of research.


Use of an inert marker (phenol red) to improve accuracy in gastric secretion studies. Gastric secretion from 24 subjects was collected by continuous nasogastric aspiration during the plateau of secretion evoked by intravenous histamine diphosphate, 0.01 mg/kg/hr. Simultaneously, phenol red was instilled at a constant rate into the proximal part of the stomach. Concentrations of phenol red in 15-minute aspirates were measured, and used to deduce pyloric losses and the reasons for random variation in the volumes aspirated. The average coefficient of variation in the volume was 26%, irrespective of the nature of the nasogastric tube. Correction by phenol red reduced this value to 21%. The coefficient of variation of volume diminished as secretion rate increased. Pyloric losses amounted to 7 ml/15 min, and were independent of the secretion rate. The quantitative effect of these errors upon the assessment of gastric secretion was minimal at high secretion rates but important at low rates.


The implications of bile in the stomach.


Inial studies of isolated kidney perfusion.


The importance of keeping bile salts in their place.


The simulation of weightlessness using water immersion techniques: an annotated bibliography.


Incidence of haemolytic escherichia coli infections in man.


Observations on the haemolysins of escherichia coli.


Research in preventive dentistry.

Research in preventive dentistry.


The history of Freud's concepts of regression.


A better outlook for surgery in paraplegics.


Porphyria--'the royal malady'.

Porphyria--'the royal malady'.


Kinetic and comparative studies on localized leukocyte mobilization in normal man.


Negro physicians in Michigan.

Negro physicians in Michigan.


The implantation of human dentin and cementum with autogenous red marrow into the subcutaneous tissues of the rat.


Review of the literature: the methodology of clinical calculus evaluation.


A clinical method for the prediction of closure of the central diastema.


" ... Beside the white chickens".

" ... Beside the white chickens".


A chronology of growth of the human dentition.


A bibliography of histoplasmosis.

A bibliography of histoplasmosis.


Hypothyroidism after treatment with sodium iodide I-131. Incidence and relationship to antithyroid antibodies, long-acting thyroid stimulator (LATS), and infiltrative ophthalmopathy.


Maxillary labial frenum and midline diastema.


Spontaneous hematopoietic neoplasms of free-living and captive wild mammals.


Editorial. DR--doubtful reader.

Editorial. DR--doubtful reader.


Perspectives in comparative oncology.

Perspectives in comparative oncology.


Hamster lymphoma, TM.

Hamster lymphoma, TM.


The prevalence of enamel defects in childhood nephrotic syndrome.


Non-neoplastic lesions of lymph nodes of man to be differentiated from lymphomas.


Hematopoietic neoplasms of rats and mastomys.


Role of mycoplasma in exudative pharyngitis.


Joseph Goldberger, M.D. (1874-1929). Part II. The climactic years (1914-1929).


Infantile cortical hyperostosis: a study to determine if residual deformities exist in mandibles.


Alterations in states of consciousness associated with chronic ingestion of alcohol.


Sugar intolerance.

Sugar intolerance.


In memoriam. Professor Sutomo Tjokronegoro 1907-1969.


EEG correlates of psychopathology.

EEG correlates of psychopathology.


Bronchoscopy in paediatrics.

Bronchoscopy in paediatrics.


The biometric approach to psychopathology--revisited.


Autonomic and somatic reactivity in relation to psychopathology.


Current bibliography on allergy and applied immunology.


Altered ribosomal protein in streptomycin-dependent Escherichia coli. We have compared the 30S ribosomal proteins of strains of Escherichia coli sensitive to and dependent on streptomycin and identified a single protein that is functionally altered in the ribosomes dependent on streptomycin. This protein (30S-15) is the same protein that is functionally altered in ribosomes resistant to streptomycin.


Dr. Wilfred D. David succeeds Dr. John W. Ferree as director of NSPB.


Antigenicity: some molecular aspects.

Antigenicity: some molecular aspects.


Oral contraceptives: their side effects and ophthalmological manifestations.


A review of the actions and effects of immunosuppressive drugs.


Normal tissue antigens of tumor cells.

Normal tissue antigens of tumor cells.


Thomas Jefferson and the doctors.

Thomas Jefferson and the doctors.


Felix d'Herelle and bacteriophage therapy.


The public practice of midwifery in Philadelphia.


Medicine, music and academia.

Medicine, music and academia.


Notes on the history of medicine in Hungary.


Autonomic response patterning of chronic schizophrenics.


Memoir of William Bates, 1889-1967.

Memoir of William Bates, 1889-1967.


Memoir of Edward Foulke Corson, 1883-1967.


Memoir of John Arthur Daugherty, 1902-1968.


Memoir of John Evan Davis , Jr., 1908-1968.


Memoir of Samuel Creadick Rhoads, 1900-1968.


Memoir of Reuben Lore Sharp, 1897-1968.

Memoir of Reuben Lore Sharp, 1897-1968.


Memoir of Calvin Mason Smyth, Jr., 1894-1967.


Dr. William Bryant (1730-86): American physician and antiquary.


Ultrastructural study of secretory granules in the juxtaglomerular cells--particularly on formation and extrusion.


Effect of lesion of the lateral geniculate body on the EEGs and photically evoked potentials in the cerebral visual, somatosensory and association areas of unanesthetized cat.


Effect of dibromomannitol and dibromodulcitol on immunological and microbiological systems.


Comparative studies on the biological properties of Escherichia coli O124:K72(B17) strains.


The role of endothelial cells in the pathogenesis of atherosclerosis.


General anaesthesia for cardiac catheterisation in children. The effect of spontaneous or controlled ventilation on the evaluation of congenital abnormalities.


Bone tumors among the atomic bomb survivors of Hiroshima and Nagasaki.


A critical assessment of supraclavicular brachial plexus block.


Humidification requirements and techniques. Including a review of the performance of equipment in current use.


Ventilatory problems with congenital diaphragmatic hernia.


Regulation of heme and cytochrome synthesis in Spirillum intersonii.


Vitamin B12 metabolism in thalassemia major.


The effectiveness of a teething solution in infants. A clinical study.


The breakdown of embryonic (chick) cartilage and bone cultivated in the presence of complement-sufficient antiserum. 3. Immunological analysis.


In memoriam. David Vaughan Davies, M.A., D.Sc., M.B., B.S., F.R.C.S., L.R.C.P.


The home of the College. 14 Princes Gate.


Effect of casting conditions on physical properties of some experimental partial denture alloys.


High blood pressure--ancient, modern and natural.


The story of a 'little black bag'.

The story of a 'little black bag'.


Results of a double blind study of the influence of thalidomide on the lepra reaction.


Correspondence: Myocobacterium leprae in foot pads of hairless mice.


Antitumor activity of the nitrofuran derivatives against Ehrlich ascites tumor.


Venous-arterial Pco2 difference in hemorrhagic shock.


Hawaii--a historical note.

Hawaii--a historical note.


Basic considerations on the use of pressor drugs.


Lymphoma and the urinary tract.

Lymphoma and the urinary tract.


Comparison of amphetamine sulphate and caffeine citrate in man.


131-I hippuran in the evaluation of transplanted kidneys.


Radiation fractionation as applied to murine colony-forming cells in differing proliferative states.


A quality control program for clinical microbiology.


Fluorescent and serologic technics in the identification of enteropathogenic Escherichia coli.


Oxygen toxicity during artificial ventilation.


Pulmonary structural changes in neonatal hyaline membrane disease treated with high pressure artificial respiration.


Rapid giant paper sections of lungs.

Rapid giant paper sections of lungs.


HL-A antigens and genes. 3. Production of HL-A typing antisera of desired specificity.


Occurrence and assay of alpha-N-acetylgalactosaminyl transferase in the gastric mucosa of humans belonging to blood group A.


HL-A antigens and genes. II. Studies of the antigen MH (=HL-A5) of the 4 sub-locus.


Nucleopores of the giant amoeba, Pelomyxa carolinensis.


Light and electron microscopic identification of several types of endocrine cells in the gastrointestinal mucosa of the cat.


Electron microscopic observations on iron-labelled secondary lysosomes in renal tubules in mice.


The fine structure of the salivary glands of the desert locust Schistocerca gregarii Forskål.


Cardiac muscle. A comparative ultrastructural study with special reference to frog and chicken hearts.


Interference filters for improved immunofluorescence microscopy.


McCollum Award. Dr. Edward H. Ahrens, Jr.


Human nutrition research in Yugoslavia.

Human nutrition research in Yugoslavia.


Roentgenological characteristics of mesenchymal tumours of the stomach. A retrospective study of 59 patients.


The lactose tolerance test with intravenous administration of ethanol.


Fluorescent treponemal antibody (FTA) reaction in sera with antinuclear factors.


Primary necrotizing enterocolitis in infants.


Erythropoietin activity in autotransplanted canine kidneys.


Historic battle for the freedom of general practice in England.


Professor John Fleming Brock.

Professor John Fleming Brock.


Thalamic target localization in stereotaxic surgery: a comparison of the accuracy of radiologic and electrophysiologic methods.


Quantitative assessment of thalamotomy for Parkinsonism.


Polar coordinates and television monitoring in stereotaxic brain surgery.


Stereotaxic surgery in a community hospital.


Time perception in patients with depressed consciousness and Parkinson's disease. I. Experimental results.


Tremor of attitude.

Tremor of attitude.


Hemiballismus as a complication of thalamotomy: report of two cases.


Transient anosognosia associated with thalamotomy: is it caused by proprioceptive loss?


Indications for stereoencephalotomies. A critical assessment.


A stereotaxic approach and evaluation of the cerebellar nuclei of man.


Effect of deafferentation of an arm upon the tremor of the opposite arm.


Treatment of temporal-lobe epilepsy by stereotactic surgery.


Remote telemeter stimulation and recording from implanted temporal lobe electrodes.


Stereotactic thrombosis of intracranial aneurysms.


Stereotactic thrombosis of intracranial aneurysms using a magnetic probe.


Stereotaxy of sella turcica.

Stereotaxy of sella turcica.


Midline defects of the back: Pediatric view.


Characterization of the membrane protein component of the lactose transport system of Escherichia coli.


Beta-hydroxydecanoyl thioester dehydrase. Studies on molecular structure and active site.


Alpha-keto acid dehydrogenase complexes. XII. Effects of acetylation on the activity and structure of the dihydrolipoyl transacetylase of Escherichia coli.


Putrescine biosynthesis in Escherichia coli. Regulation through pathway selection.


Studies on the interchangeability of one of the mammalian and bacterial supernatant factors in protein biosynthesis.


A new method for the large scale purification of Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase.


Separation and characterization of the subunits of ribonucleic acid polymerase.


Enzymatic breakage of deoxyribonucleic acid. II. Purification and properties of endonuclease IV from T4 phage-infected Escherichia coli.


The function of pseudouridylic acid in transfer ribonucleic acid. II. Inhibition of amino acyl transfer ribonucleic acid-ribosome complex formation by ribothymidylyl-pseudouridylyl-cytidylyl-guanosine 3'-phosphate.


Protein turnover in amino acid-starved strains of Escherichia coli K-12 differing in their ribonucleic acid control.


An immunofluorescence study of the in vitro interaction between lymphoid cells and target cells.


Evaluation of the immunosuppressive properties of ribonuclease complexes.


The toxicity of meningopneumonitis organisms (Chlamydia psittaci) at different stages of development.


Heterogeneity of mouse myeloma gamma G globulins as revealed by enzymatic proteolysis.


Detection of anti-phage antibody by passive hemagglutination.


Immunosuppression by antibody: localization of site of action.


Criminal laws and the control of drugs of abuse. An historical view of the law (or, it's the lawyer's fault).


Effects of chronic pretreatment with pargyline upon responses of the atrial pacemaker and of left atrial strips of guinea pigs to tyramine, mephentermine, d-amphetamine and adrenergic nerve stimulation.


The treatment of advanced breast cancer.


A clinical trial of ethambutol plus capreomycin in the treatment of atypical tuberculosis.


Trial of an anti-anxiety compound--doxepin (Sinequan).


Physician protests elimination of Pap smears from Medicare coverage.


The role of government in future medical practice.


Clinical pharmacology 1969.

Clinical pharmacology 1969.


Experimental studies and clinical observations with Myelobromol.


The bacterial growth-delaying effect of the intravenously administered chloramphenicol-succinate-sodium.


Lack of evidence for oncogenic or amyloid inducing qualities of Mycoplasma neurolyticum inoculated into BALB-c mice.


The fluorescent antibody technique in the diagnosis of enteropathogenic Escherichia coli, with special reference to sensitivity and specificity.


Elimination of iodine-labelled fibrinogen in intravascular coagulation and in the normal state. Experimental and clinical studies.


Isolation and characterization of N6-methyladenosine from Escherichia coli valine transfer RNA.


Recovery of transfer RNA functions by combining fragmented Escherichia coli formylmethionine transfer RNA.


Isolation and characterization of Euglena gracilis cytoplasmic and chloroplast ribosomes and their ribosomal RNA components.


Protein-ribonucleic acid interactions in ribosomes.


On the mechanism of inhibition by fluoride ions of the DNA polymerase reaction.


Studies of the impaired inducibility in relaxed mutants of Escherichia coli.


Large-scale preparations of viruses by steric chromatography on columns of controlled pore glass. Phi-X174, M13, M12, Q-beta and T4 bacteriophages.


Incorporation of amino acids into phage-like particles in cell-free systems of Escherichia coli.


Chain initiation during polypeptide synthesis in cell-free bacterial systems programmed with plant viral messengers. 3. A comparison with the phage RNA-directed system.


Energy transfer in the DNA-chloroquine complex.


Salmonella typhimurium pericarditis.

Salmonella typhimurium pericarditis.


Cholinergic innervation of the autotransplanted canine kidney.


Effect of methyldopa on plasma renin activity in man.


Measurement of renal blood flow with Xenon 133 during human kidney transplantation.


Lymphatic aspects of experimental and clinical renal transplantation.


Our experience in kidney transplantation.


The influence of the mode of nutrition on the digestive system of Ochromonas malhamensis. The intracellular distribution and level of acid hydrolases in Ochromonas malhamensis were studied in cells grown osmotrophically in a defined medium, in a carbon-free starvation medium, and during phagotrophy in each of these media. By cytochemical techniques, little enzymic reaction product was observed in the vacuoles of osmotrophic cells grown in the defined medium. Starved cells, however, contained autophagic vacuoles and cannibalized other Ochromonas cells. Dense enzymic reaction product was observed in the digestive vacuoles and in the Golgi cisternae of these starved cells. Moreover, starved cells and cells grown in a nutritionally complete medium ingested Escherichia coli which appeared in digestive vacuoles containing enzymic reaction product. Biochemical assays for lysosomal acid phosphatase (E.C. 3.1.3.2 orthophosphoric monoester phosphohydrolase) and acid ribonuclease (E.C. 2.7.7.16 ribonucleate nucleotido-2'-transferase) were done on Ochromonas cultures in the same experimental treatments and under identical assay conditions as the cytochemical study. During starvation, the acid hydrolase specific activities were consistently twice those found in cells grown in an osmotrophic complete medium. Ochromonas fed E. coli showed no increase in acid hydrolase specific activity as compared to controls not fed E. coli. The latency of lysosomal acid hydrolases in cells fixed with glutaraldehyde was reduced, suggesting that this fixative increases lysosomal membrane permeability and may release enzymes or their reaction products into the cytoplasmic matrix during cytochemical analysis. This could explain the cytoplasmic staining artifact sometimes observed with glutaraldehyde-fixed cells when studied by the Gomori technique. This study confirms that Ochromonas malhamensis, a phytoflagellate, does produce digestive vacuoles and can ingest bacteria, thereby fulfilling its role as a heterotroph in an aquatic food chain. When Ochromonas is grown in a nutritionally complete osmotrophic medium, phagocytosis causes appearance of acid hydrolases in the digestive vacuoles, whereas the total activity of the enzymes remains unchanged. An organic carbon-free medium strongly stimulates acid hydrolaes activity and causes these enzymes to appear in the digestive vacuoles whether phagocytosis occurs or not.


High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. A new technique employing continuous recirculating perfusion of the rat liver in situ, shaking of the liver in buffer in vitro, and filtration of the tissue through nylon mesh, results in the conversion of about 50% of the liver into intact, isolated parenchymal cells. The perfusion media consist of: (a) calcium-free Hanks' solution containing 0.05% collagenase and 0.10% hyaluronidase, and (b) magnesium and calcium-free Hanks' solution containing 2 mM ethylenediaminetetraacetate. Biochemical and morphologic studies indicate that the isolated cells are viable. They respire in a medium containing calcium ions, synthesize glucose from lactate, are impermeable to inulin, do not stain with trypan blue, and retain their structural integrity. Electron microscopy of biopsies taken during and after perfusion reveals that desmosomes are quickly cleaved. Hemidesmosome-containing areas of the cell membrane invaginate and appear to pinch off and migrate centrally. Tight and gap junctions, however, persist on the intact, isolated cells, retaining small segments of cytoplasm from formerly apposing parenchymal cells. Cells which do not retain tight and gap junctions display swelling of Golgi vacuoles and vacuoles in the peripheral cytoplasm. Cytoplasmic vacuolization in a small percentage of cells and potassium loss are the only indications of cell injury detected. By other parameters measured, the isolated cells are comparable to normal hepatic parenchymal cells in situ in appearance and function.


Suicidal gunshot wounds of the abdomen.

Suicidal gunshot wounds of the abdomen.


Renal ischemia and homograft rejection. Preliminary angiographic data in the dog.


Report on two early United States firearms identification cases.


Macroglobulin antibodies in the natural immune response to endotoxin in Escherichia coli associated enteritis in the weaned pig.


The historical development of insanity as a defense in criminal actions. II.


Synthesis and biological activity of some new N6-substituted purine nucleosides.


The present status of the IgM fluorescent antibody technique in the diagnosis of congenital toxoplasmosis.


Some results on an immunochemical analysis of fluorescein-conjugated antihuman IgM sera.


Fluorescent antibody test for neonatal congenital syphilis: a progress report.


Clinical evaluation of a new anthelmintic; phenylene di-iso thiocyanate (Bitoscanate) in hookworm and roundworm infestation.


The black death.

The black death.


Medicine without frontiers: the peripatetic physician.


Problems and results of cardiac transplantation.


Mechanical assistance to the circulation: the principle and the methods.


Assisted circulation in the experimental preparation--with special reference to pulmonary embolism and acute myocardial ischemia.


Fluorosis and fluoridation.

Fluorosis and fluoridation.


The present status of corticosteroid therapy in liver diseases.


The correlation between gastric acid secretion and histology of fundic and antral gland area.


Chemotherapy of chronic myelocytic leukemia.


The treatment of chronic lymphocytic leukemia.


Modern approaches to the radiotherapy of lymphoma.


Alexander Raymond Stevens, 1876-1968.

Alexander Raymond Stevens, 1876-1968.


The therapy of lymphoma.

The therapy of lymphoma.


Gilbert Joshua Thomas, 1884-1968.

Gilbert Joshua Thomas, 1884-1968.


Presentation of Keyes medal to Dr. Edgar Burns.


Meredith Fairfax Campbell, 1894-1969.

Meredith Fairfax Campbell, 1894-1969.


Chronic bacterial prostatitis and the diffusion of drugs into prostatic fluid.


Urinary infection: review of 16,154 consecutive patients.


Donald Austin Charnock, 1893-1968.

Donald Austin Charnock, 1893-1968.


John Tenbroeke MacLean, 1910-1968.

John Tenbroeke MacLean, 1910-1968.


James C. McClelland, 1889-1969.

James C. McClelland, 1889-1969.


Cell selection by antigen in the immune response.


Death in Venice: the aesthetic object as dream guide.


The manifest and the latent content of two paintings by Hieronymus Bosch: a contribution to the study of creativity.


Thomas Mann's Death in Venice.

Thomas Mann's Death in Venice.


An empirically-based formulation of hypnotism.


Letters to the editor. Medicare.

Letters to the editor. Medicare.


A selected public health bibliography with annotations.


Psychosomatic effects of specific types of training.


Emotion, motivation, and the limbic system.


Neuro-ethological approaches to the study of emotional behavior: stereotypy and variability.


Perinatal determinants of emotionality.

Perinatal determinants of emotionality.


The role of early experience in emotional arousal.


The aerobic and anaerobic flora of rattlesnake fangs and venom: therapeutic implications.


Microbiological studies of a laminar air flow unit for patients.


A guide for laboratory diagnosis and postexposure treatment of rabies.


A direct fluorescent antibody test for Salmonella.


Salmonella typhimurium infection in house sparrows.


Bustles and bodices.

Bustles and bodices.


How does comprehensive health care relate to the health care industry?


A clinical study of the effects of an aldosterone antagonist (Aldactone-A) and a thiazide diuretic (Enduron) in pregnancy.


Asymptomatic bacteriuria during pregnancy.


Natural antibodies.

Natural antibodies.


Construction of custom made trays.

Construction of custom made trays.


Dental students publish a 'first edition'.


Making dentures bearable for your patients.


Alphabetical listing. Delta Sigma Delta.


Georgrahical listing. Delta Sigma Delta.


Hypertension in renal parenchymal disease.


The psychosocial adjustment of children with dyslexia.


More thoughts on feed additives.

More thoughts on feed additives.


The viability and vicissitudes of behavior therapy.


Prospects for psychiatry and psychoanalysis.


Significance of the small lumbar spinal canal: cauda equina compression syndromes due to spondylosis. 1. Introduction.


Concepts of fecal streptococci in stream pollution.


The production of granulomata by antigen-antibody complexes.


Neil Duncan Fraser, 1900-1969.

Neil Duncan Fraser, 1900-1969.


Indomethacin in the management of erythema nodosum leprosum--a double-blind controlled trial.


The detection of environmental mutagens.


Immunologic bases for injection therapy of allergic diseases.


Newer concepts regarding digitalis therapy.


Drug therapy for neoplastic disease in adults.


Physiology and pharmacology of belladonna therapy in acid-peptic disease.


Physiologic and biochemical basis for the treatment of gout and hyperuricemia.


Effects of Sephadex fractions of chick embryo extract on growth and differentiation of endothelial cells from chick embryo hearts in culture.


Ethanol: drug, "hepatotoxin," and modifier of intermediary metabolism.


Damage and repair in partial ultraviolet irradiation of single HeLa cells in culture.


Effects of ionizing radiations on central nervous system in tissue culture.


Sources of experimental amnesia.

Sources of experimental amnesia.


Dimensions of LSD, methylphenidate and chlordiazepoxide experiences.


Chlordiazepoxide, expectation and hostility.


Dose-response effects of secobarbital on human memory.


Effect of nitrazepam, amylobarbitone sodium and placebo on the electroencephalogram of normal subjects.


Effects of nitrazepam, amylobarbitone and placebo on some perceptual, motor and cognitive tasks in normal subjects.


The ultrastructure of endocrine glands.

The ultrastructure of endocrine glands.


Urinary excretion of epinephrine, norepinephrine, dopamine and tryptamine during sleep and wakefulness. Effects of pentobarbital, pentobarbital plus dextroamphetamine sulfate, and placebo.


Comparative aspects of uterine-luteal relationships.


Steroid dynamics under steady-state conditions.


List of members association for research in nervous and mental disease.


The technique in renal biopsy.

The technique in renal biopsy.


Coagulation and fibrinolysis after renal transplantation.


Cooling characteristics in dental castings.


Function of canine renal autografts after extracorporeal preservation.


In memory of Dr. David M. Kissen: his work and his thinking.


Tumor-specific transplantation antigens.


Psychoendocrine considerations in cancer of the breast.


Induced carcinogenesis under various influences on the hypothalamus.


Perspectives on primary prevention. A review.


Isolation and properties of mutants of Escherichia coli with increased phosphorylations of thiomethyl-beta-galactoside.


"O" antibody levels to Escherichia coli in pigs.


Clinical pathological conference.

Clinical pathological conference.


Microbial production of glutamic acid.

Microbial production of glutamic acid.


The use of antigen-antibody precipitates for specific detection of antigens in tissue sections.


The genetic control of histocompatibility iso-antigens.


Prolonged adjuvant stimulation in germ-free BALB-c mice: development of plasma cell neoplasia.


Total pulmonary and airway resistances as measures of the relief of bronchospasm.


The development of neurological surgery in the United States.


Histological differences between soleus and gastrocnemius muscles in the mouse after the local injection of botulinum toxin.


Bayliss and Starling and the happy fellowship of physiologists.


Evaluating removable partial dentures by mathematical equations.


A simplified procedure for bilateral splinting of abutment teeth.


The transosteal mandibular dental implant.


Fabrication of orbital prosthesis.

Fabrication of orbital prosthesis.


Doxepin and diazepam in general practice and hospital clinic neurotic patients: A collaborative controlled study.


Some research approaches toward minimizing herbicidal residues in the environment.


The decontamination of animal feeds.

The decontamination of animal feeds.


Decontamination of pesticides in soils.

Decontamination of pesticides in soils.


Interaction of dequat and paraquat with clay minerals and carbon in aqueous solutions.


Kinetics of hydrolysis of diazinon and diazoxon.


Reduction of parathion residue on celery.


Attenuation of pesticidal residues on seeds.


Canning operations that reduce insecticide levels in prepared foods and in solid food wastes.


Accelerated removal of pesticides from domestic animals.


Chemical and thermal methods for disposal of pesticides.


Bacterial changes in sea water samples, due to storage and volume.


Desiccation of the precorneal film. II. Permanent discontinuity and dellen.


Immunohistological studies on human diabetic and non-diabetic eyes. I. Fluorescent labelling of insulin and insulin antibodies.


White racism: its root, form, and function.


Psychiatric perspectives on T-groups and the laboratory movement: an overview.


Psychiatric aspects of Klinefelter's syndrome.


Our medical heritage.

Our medical heritage.


A teacher rating scale for use in drug studies with children.


1969 anniversaries.

1969 anniversaries.


A study of the effects of hydrostatic pressure on macromolecular synthesis in Escherichia coli. In cultures of Escherichia coli 15 (thymine(-), leucine(-)) which were incubated at high hydrostatic pressures, cell division occurred only at pressures below 430 atm but in a somewhat synchronous fashion at around 250 atm. The rate of leucine-(14)C incorporation into a macromolecular fraction of the cells diminished to a zero value at about 580 atm and that of uracil-(14)C incorporation to a zero value at about 770 atm. The rate of thymine-(14)C incorporation at pressures around 330 atm was that to be expected with a culture in which DNA synthesis is somewhat synchronous. At pressures above 500 atm, thymine-(14)C was incorporated only over the initial part of the pressure incubation and further incorporation under pressure was not observed no matter how long the duration of the incubation. We present evidence along several lines that the thymine incorporation kinetics reflect an effect of pressure on a locus at the origin (or termination) of a replication of the bacterial chromosome. The recovery of cell division and of the incorporation rates upon release of pressure were found to depend on the magnitude of the pressure and the duration of the pressure incubation.


Influence of E. coli endotoxin on the pulmonary veins, circulatory system and work and ne of the heart of intact dog.


Unexpected results of intravenous therapy with antilymphocyte serum in organ transplantations.


Further evidence of third party unresponsiveness in immunologically tolerant animals.


A quantitative comparison of the antigenic structure of a virulent and an avirulent strain of Salmonella typhimurium.


The response to Salmonella typhimurium antigens by two different strains of mice.


Chloramphenicol-specific antibody. IV. Neutralization of antibiotic effect on Escherichia coli.


Biographical directory of members of the International Association of Dental Research.


The 50 year history of the Journal of Dental Research. The interim editor (1935).


The 50 year history of the Journal of Dental Research. The longest editor (1936-1958).


The 50 year history of the Journal of Dental Research. The last editor of the first 50 years (1958-1969).


The 50 year history of the Journal of Dental Research. The newest editor.


The 50 year history of the Journal of Dental Research.


The 50 year history o the Journal of Dental Research. The Board of Editors, the Advisory Editorial Board and the final page.


The 50 year history of the Journal of Dental Research. The founding editor (1919-1935).


Microgliomatosis presenting with dementia and hypopituitarism.


Immunofluorescence studies with antisera to human growth hormone and human placental lactogen on adenohypophyses of pregnant and parturient women.


Introduction of the Rudolf Virchow lecturer.


Diagnostic testing and the new alternatives.


Positive conditioned reinforcement from aversive situations.


Larval skin of the flathead sole, Hippoglossoides elassodon.


Microbial contamination of oral liquid medications.


Fate of successful corneal grafts in Fuchs' endothelial dystrophy.


Suppression of the immune response in keratoplasy.


Intraolar pressure following penetrating keratoplasty.


Alfred Newton Richards: curriculum vitae and honors.


Alfred Newton Richards 1876-1966.

Alfred Newton Richards 1876-1966.


Dr. A. N. Richards and kidney micropuncture.


Bibliography of Alfred Newton Richards.

Bibliography of Alfred Newton Richards.


Other activities of Dr. Richards' department: "Clinical Pharmacology".


On working with Dr. Richards in Philadelphia. Recollections.


The Lobster memorial parties.

The Lobster memorial parties.


Dr. Richards' pupils and their later accomplishments.


Dr. Richards as Chairman of the Committee on Medical Research.


Advantages and dangers of government support for medical research. Extract from an address to the John Morgan Society.


Alfred Newton Richards, scientist and man.


A memorial written for the medical faculty of the University of Pennsylvania.


Mechanisms of radiation mutagenesis in cellular and subcellular systems.


Double cadaver renal transplantations: an analysis of twenty-one pairs with special reference to the effect of variations in ischemia time.


Plasma activity of antihemophilic globulin (AHG) and other coagulation factorsin Swiss type of agammaglobulinemia.


Classification of depressive illness.

Classification of depressive illness.


Surgical history of pulmonary tuberculosis: the rise and fall of various technical procedures.


Experimental coarctation of the aorta: hemodynamics and histological studies.


Malignant mesenchymoma of the mandible.

Malignant mesenchymoma of the mandible.


Free ovarian autografts within the uterus.


Superior vena caval system obstruction caused by benign endothoracic goiter.


The effect of intravenous aminophylline on pulmonary function in asthma. A double-blind study.


Medical history. Osler's alter ego.

Medical history. Osler's alter ego.


Slow moving protease and the seven pepsinogens. Electrophoretic demontration of the existence of eight proteolytic fractions in human gastric mucosa.


Effect of feeding on the protein synthesis in mammalian pancreas.


Contact and delayed hypersensitivity in the mouse. II. The role of different cell populations.


Immunoglobulin IgA in the urine of conventional and colostrum-deprived hypogammaglobulinaemic pigs.


Response to phytohaemagglutinin of lymphocytes from mice treated with anti-lymphocyte globulin.


Burn and Rand's hypothesis.

Burn and Rand's hypothesis.


Intestinal anastomosis following post-operative evisceration in a bitch.


Organ transplas.

Organ transplas.


A plate test for staphylococcal coagulase.


Development and use of multi-inoculation test methods for a taxonomic study.


Localization of immunological complexes fixing beta1C (C3) in germinal centers of lymph nodes. 28 human and 60 experimentally stimulated rabbit lymph nodes were studied by means of light microscopy and immunofluorescence. 21 of the 28 human lymph nodes showed well-developed germinal centers. IgM, IgG, and the beta(1C) component of complement were found in the same distribution within germinal centers when examined in serial cryostat sections. 36 rabbits were stimulated with Brucella antigen, and 24 rabbits with BSA. A strikingly consistent correlation between distribution and appearance of specific staining for rabbit beta(1C), IgM, and IgG was observed; when lymph nodes were stimulated with BSA, antigen and specific antibody were present. Treatment of unfixed sections with citrate-buffered saline at low pH resulted in complete elution of immunoglobulins, beta(1C), and BSA from rabbit germinal centers, and in marked diminution of IgG and IgM in human germinal centers, while at the same time plasma cells remained strongly fluorescent. Specific selective fixation of heterologous (human) complement in rabbit germinal centers positive for beta(1C), IgG, IgM, and BSA was also obtained. These data present strong evidence for the existence within germinal centers of antigen-antibody complexes which fix at least the beta(1C) component of complement in vivo. The possibility of complete elution of immunoglobulins from rabbit germinal centers can be taken as evidence that, at least for 20 days after primary and secondary stimulation, a major component of the immunoglobulins present in germinal centers is not produced locally but accumulates at the surface of cells.


An inexpensive and reliable method of negative-pressure paraffin wax embedding.


A single unit processor for small specimens in electron microscopy.


Congenital anomalies of the lower spine and spinal cord in Manx cats.


Some pitfalls in interpretation of the I.Q.


The role of antibody in experimental pyelonephritis.


A disposable isometric muscle biopsy clamp.


Undergraduate medical education.

Undergraduate medical education.


Desiderius Erasmus (1466-1536) the great humanist.


Programs in medical education sponsored by government agencies.


A preliminary controlled study of doxepin ("Sinequan") as an antianxiety drug.


Ibuprofen, aspirin and placebo in the treatment of rheumatoid arthritis--a double-blind clinical trial.


The carcinoid tumor, syndrome and spectrum. A review of the literature.


Synthesis of early RNA in bacteriophage T4-infected Escherichia coli B.


Species specificity of polypeptide chain initiation.


Isolation from faeces of cells capable of transferring R-factors at a derepressed rate.


Calcium, phosphorus, and strontium metabolism in infants.


Interactions between carbohydrate, protein, and fat metabolism in starvation.


Dietary proline in familial aminoaciduria.


Time response of jejunal sucrase and maltase activity in man.


Mental disease and drugs affecting it.

Mental disease and drugs affecting it.


Behavioral traits in rats resulting from early nutritional deprivation.


A general theory of oxygen toxicity in man.


The American Board of Plastic Surgery examinations.


Experimental finding of new bone formation after rat skull implants of polymethacryle and anorganic bone.


One-stage recontruction of substantial lower eyelid margin defects.


Peripheral nerve suturing using a nerve miter box to trim the ends.


Physical medicine and rehabilitation in pediatrics. 1.


The moral psychiatry of imperial Rome as practiced by Soranus of Ephess.


Enterobius vermicularis: 10,000-year-old human infection. Eggs of Enterobius vermicularis (human pinworm) were found in hum coprolites from Hopug and Danger Caves, western Utah. The Caves were inhabitated by man from 10,000 B.C. to A.D. 1400. The oldest coprolite containing dated at 7837 B.C. This represents the earliest known association between man abd this exclusively human parasite.


Removal of acid hematin-type pigments from sections; efficacy of alcoholic picric acid solution.


Oxidation systems in fruits and vegetables--their relation to the quality of preserved products.


Urinary diversion by cutaneous uretero-ileostomy in children with myelomeningocele.


Fluid compartments of islet and other tissues of the toadfish Opsanus tau.