Factors that determine cusp angulation.

Factors that determine cusp angulation.


Are new dentures necessary?

Are new dentures necessary?


Patient preference for a mandibular complete denture with a broad or minimal base: a preliminary report.


Multiple preparations for fixed prosthodontics.


A simplified dowel crown technique.

A simplified dowel crown technique.


Technique for constructing denture-support bearings.


A. O. DeWeese, M.D. August 25, 1888--March 10, 1970.


The accuracy of measurement of individual skeletal muscle fibres separated by a rapid technique.


Some medical pioneers in New Zealand. 1.


Michael Fitzherbert Horrocks.

Michael Fitzherbert Horrocks.


Spinal dysraphism: hidden congenital malformations.


John Russell.

John Russell.


Amniography for detection of congenital malformations.


A one-stage repair for hypospadias cripples.


An aid to hand rehabilitation following island flap transfer.


Congenital primary ectropion. Case reports.


T-shaped pharyngeal flap.

T-shaped pharyngeal flap.


Primary pharyngofixation in cleft palate repair. A survey of 46 years' experience with an evaluation of 2,073 cases.


Late effects of fast neutrons and gamma-rays in mice as influenced by the dose rate of irradiation: induction of neoplasia.


The release reaction of secretion.

The release reaction of secretion.


Boerhaave on inflammation. II.

Boerhaave on inflammation. II.


Magnesium deficiency and distribution of blood in the rat.


Resistance of E. coli ribosomal 5S RNA to degradation by ribonuclease in reconstituted ribosomal particles.


Repair deficiency in a bacterial mutant defective in DNA polymerase.


Historical background of psychotherapy as a new scientific field.


Protective effect of sodium fluoroacetate on haemopoietic stem cells of irradiated mice.


Tolerance manifestations among inbred rat strains defined in the rt H-1 antigens. II. Specific depression of antibody production in rats surviving the neonatal administration of allogeneic cells and rejecting the donor skin graft.


Tyrosine phenol lyase. I. Purification, crystallization, and properties.


Tyrosine phenol lyase. II. Cofactor requrements.


Could L-asparaginase be an antagonist of phytohaemagglutinin?


Preservation of sensation in a cutaneous vascular malformation in lepromatous leprosy.


Thyroid-hormone enhancement of imipramine in nonretarded depressions.


Childhood diarrhea in rural Guatemala.

Childhood diarrhea in rural Guatemala.


Growth in resistant rickets.

Growth in resistant rickets.


Castleman B, McNeely BU,+MACNEELY BU: Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-1970.


Relative dietary calorie-protein adequacy of preschool children in India.


Of micelles and men.

Of micelles and men.


Properties of mitochondria from mammalian cells cultured on lipid-free media.


Renal defect in magnesium deficiency.

Renal defect in magnesium deficiency.


Vitamin D sulfate.

Vitamin D sulfate.


Selenium and cancer.

Selenium and cancer.


Copper, molybdenum, sulfate: the nature of their interactions.


Effect of dietary factors on carcass composition of rats.


Serum protein binding of vitamin B12.

Serum protein binding of vitamin B12.


Origins of molecular biology.

Origins of molecular biology.


Drive theories of schizophrenia.

Drive theories of schizophrenia.


Generalized tuberculosis after BCG vaccination--report of an autopsy case.


Absorption of injected insulin. A clinical-pharmacological study.


Aerfusion catheter in the aorta for cadaveric kidney transplantation. An experimental study.


The treatment of avulsions of penis and scrotum.


Inomycin a new antibiotic of the cycloheximide group. I. Characteristics of the strain and antibiotic production.


Cytotoxic antibodies after skin allotransplantation in rabbits.


Antigenic differentiation of rabbit lymphocytes.


Measurement of acute changes in liver function and blood flow.


Angiographic evaluation of injury to the great vessels.


Lawn mower injuries in children.

Lawn mower injuries in children.


Preservation of the anoxic heart with a metabolic inhibitor and hypothermia.


Delayed spontaneous rupture of the allografted kidney.


Hypothalamic control of thyroid gland activity and gonadal activity in the goldfish, Carassius auratus.


New procedure for assay of p-hydroxybenzoic acid, precursor of coenzyme Q.


The Secretary of the College.

The Secretary of the College.


Editorial. The Golden Anniversary.

Editorial. The Golden Anniversary.


Folate activity of blood during artifical anabolism.


Use of dextran sulphate in the demonstration of bacteria in blood (preliminary report).


Application of the method of immunofluorescence for rapid diagnosis of mumps virus.


Formation of histamine during bacterial decarboxylation of histidine in the flesh of some marine fishes.


Early years of the American Board of Periodontology and the Advisory Board for Dental specialties.


Olin Kirkland 1876-1969.

Olin Kirkland 1876-1969.


Effects of a water-soluble chlorophyllin ointment on gingival inflammation.


Hemodynamics and blood gas exchange in allografted canine lungs. I. Immediate effects.


Prevention of prosthetic cardiac valve detachment.


Antonino Clementi (1888-1968).

Antonino Clementi (1888-1968).


Darwin's tubercle belongs to Woolner.

Darwin's tubercle belongs to Woolner.


Malleomyringoplasty and wireclip prosthesis.


Complications of otoplasty.

Complications of otoplasty.


Revision of the posttracheotomy scar. Correction of the depressed, retracted scar.


Indirect migration inhibition test in xenogeneic systems. I. Delayed hypersensitivity to BCG.


Medicine in primitive Indian and Eskimo art.


Osteogenesis and revitalization in experimental marrow depression by an allogenic marrow transfer vehicle.


Studies on folate and vitamin B 12 metabolism in primates. II. Vitamin B 12 binding proteins.


Similarities between glossopharyngeal breathing and injection methods of air intake for esophageal speech.


Properties of renal luminal and antiluminal transport of plasma glutamine.


Urinary procoagulant excretion and its relation to kidney function.


The effect of vaccine on a closed epidemic of Hong Kong influenza.


An investigation into the effects of imipramine hydrochloride on the incidence of enuresis in institutionalized children.


A decade of pediatric urology.

A decade of pediatric urology.


Denture stomatitis. I. The etiology in relation to trauma and infection.


Pepsins--a chromatographic and kinetic comparison.


A simple plate-assay method for distinguishing between competitive and noncompetitive antagonism.


Membrane and nonmembrane proteins of mammalian cells. Synthesis, turnover, and size distribution.


Isolation and some properties of methionine transfer ribonucleic acid from Escherichia coli.


Studies on the association of beta-chain monomers of Escherichia coli tryptophan synthetase.


Optical rotatory dispersion and circular dichroism studies on Escherichia coli ribonucleic acid polymerase.


Studies on deoxyribonucleic acid polymerases from yeast. 1. Parial purification and properties of two DNA polymerases from mitochondria-free cell extracts.


Ionic effects on the ribosomal quaternary structure.


The mode of action of 5-aza-2'-deoxycytidine in Escherichia coli.


A steady-state kinetic investigation of the reaction mechanism of the tryptophan synthetase of Escherichia coli.


Studies on deoxyribonucleic acid polymerases from yeast. 2. Partial purification and characterization of mitochondrial DNA polymerase from wild type and respiration-deficient yeast cells.


Emil Froeschels on his 85th anniversary.


Generalized herpes simplex in malnourished children. Five cases of fatal generalized herpes simplex infection in malnourished children are described. This is almost certainly a much more common disease in underdeveloped communities than is at present appreciated. Only a greater awareness of the disease, coupled with full use of histological and cultural methods of diagnosis, will lead to knowledge of its true frequency.A case of neonatal infection, the first recorded in an African, is also described. Reasons are suggested as to why this disease should be seen in malnourished infants in Africa but only very rarely in neonates.


The biological false positive reaction to serological tests for syphilis. Acute and chronic biological false positive reactions to serological tests for syphilis are discussed. Three cases are presented, one showing an acute and one a chronic reaction, and one in which it was not possible to determine if the reaction was acute or chronic. Once a biological false positive reaction is found, serum from the patient should be tested at intervals for at least six months to determine if the reaction is acute or chronic. If a chronic reaction is found the patient should then be investigated to find the underlying cause. Problem sera from 753 patients are reviewed. Biological false positive reactions were shown by 47 sera and 257 sera gave results indicating they came from patients infected with syphilis. The reactive sera were divided into four groups: sera from blood donors, antenatal patients, cases of recent vaccination, and a miscellaneous group. It was found that in the first three groups the number of sera from patients showing biological false positive reactions was equalled or exceeded by the number showing syphilitic reactions. Biological false positive reactions in sera from cases of lepromatous leprosy and in sera from the inhabitants of the Okapa region of New Guinea are also discussed. It is concluded that sera which give reactive results to reagin detection tests for syphilis and come from patients known to have conditions which cause acute or chronic biological false positive reactions should never be dismissed as such. Experience has shown that a number of these sera will give reactive Treponema pallidum immobilization test results, that is, they come from patients who have or have had syphilis.


New therapy for postintubation laryngeal edema and tracheitis in children.


Centennial of the founding of the alumni association of the Jefferson Medical College.


Pathological changes in virus infections of the lower respiratory tract in children. The pathological changes are described in 22 children with proven or suspected virus infection of the lower respiratory tract. Two main patterns of disease were found: acute bronchiolitis and interstitial pneumonia. Particular viruses were not specifically associated with particular histological changes. The prime importance of the respiratory syncytial virus (RSV) as a cause of disease and death in young infants is again shown. Structural lesions and clinical dysfunction correlate fairly well; in acute bronchiolitis the main lesion is epithelial necrosis when a dense plug is formed in the bronchiolar lumen leading to trapping air and other mechanical interference with ventilation: in interstitial pneumonia there is widespread inflammation and necrosis of lung parenchyma, and severe lesions of the bronchial and bronchiolar mucosa as well. The implications of these structural changes for clinical management are discussed. The possibility of a hypersensitivity reaction in the cot death syndrome is raised, mediated by a serum antibody-antigen-complement reaction.


Sequence of authors' names in scientific articles.


Anson Jones (1798-1858), last president of the Republic of Texas.


Frederic S. Dennis and penicillium glaucum.


The epidemiology of adverse drug reactions. A review and perspective.


Duncan Struan Maxwell.

Duncan Struan Maxwell.


Retrograde cerebral emboli during procedures to clear arterial thrombi from haemodialysis shunts.


Bacteriologic research technics. Antibiotic screening.


Antibiotics today.

Antibiotics today.


Observations concerning the appearance of serum antivessel antibodies in the course of certain dermatoses.


Routine uroscreen test in antenatal patients.


Comparison between intranasal and transbuccal oxytocin for the induction of labour. Preliminary report.


Half-life of oxytoxin in blood of pregnant and non-pregnant woman.


A comparison between the efficacy and side-effects of oral contraception using closely related combined and sequential preparations.


The effect of different coagulation methods on the pathological picture of the cervix.


Sulfonic esters of carbohydrates. II.

Sulfonic esters of carbohydrates. II.


Richard Kuhn; 1900-1967.

Richard Kuhn; 1900-1967.


Unsaturated sugars.

Unsaturated sugars.


Gums and mucilages.

Gums and mucilages.


Auscultatory features of acute tricuspid regurgitation.


Glycosphingolipids (sugar-sphingosine conjugates).


The nitro sugars.

The nitro sugars.


In Memoriam. Howard W. Peterson 1904-1969.


Theodore Tuffier on experimental surgery of heart valves.


In Memoriam. Howard W. Tweed 1904-1969.

In Memoriam. Howard W. Tweed 1904-1969.


In vitro methylation of tRNA by extracts of Chlamydomonas reinhardi.


Escherichia coli B 5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: catalysis by a reconstituted methyl-14C-cobalamin holoenzyme and the function of S-adenosyl-l-methionine.


Escherichia coli phosphoenolpyruvate carboxylase: competitive regulation by acetyl-coenzyme A and aspartate.


N'-(substituted) pantothenamides, antimetabolites of pantothenic acid.


Escherichia coli B 5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: resolution and reconstitution of holoenzyme.


Spot lights on the difficulties and complications encountered in corneal transplantation.


Empiricism and rationalism in the works of Thomas Sydenham.


Management of diabetic retinopathy.

Management of diabetic retinopathy.


Sir William Temple and the therapeutic use of moxa for gout in England.


Early corneal regrafting.

Early corneal regrafting.


Our experiences with curative keratoplasty.


The College of Physicians and the acceptance of iatromechanism in England, 1665-1695.


Keratoconus and keratoplasty.

Keratoconus and keratoplasty.


Intraocular pressure and keratoplasty.

Intraocular pressure and keratoplasty.


De-epithelialization of donor's cornea in penetrating transplantation for keratoconus.


The nature and extent of speed use in North America.


Gram-negative septicemia.

Gram-negative septicemia.


A hematological artifact from 4th century Britain.


Paul Ehrlich (1854-1915).

Paul Ehrlich (1854-1915).


A comparison of the wealth, prestige, and medical works of the physicians of Salah al-Din in Egypt and Syria.


Department of Oral Surgery, Philadelphia General Hospital, Philadelphia.


Sanford Vincent Larkey (1898-1969).

Sanford Vincent Larkey (1898-1969).


Empiricism and eighteenth-century French surgery.


Heterologous aortic valves for mitral replacement. Methods of preparation and preservation and operative technique.


Immediate mandibular reconstruction with iliac bone after surgery for ameloblastoma.


Fate of autologous pericardium and dacron fabric used as substitutes for total atrial septum in growing animals.


Classic descriptions of neurological disorders by Charles Morehead.


Some aspects of history of general paralysis of insane.


Effect of gastrointestinal hormones on insulin and glucagon secretion.


The cholesterol-lowering effect of dextran-40.


Gas embolism in hyaline-membrane disease.


Curricular change changeless.

Curricular change changeless.


Mace as a co-carcinogen.

Mace as a co-carcinogen.


A tribute to Warren W. Furey, M.D.

A tribute to Warren W. Furey, M.D.


Introduction of annual orator, Leo G. Rigler, M.D.


Frank Theodore Moore, M.D., 1901-1969.

Frank Theodore Moore, M.D., 1901-1969.


Cholera.

Cholera.


Growth stimulation of long bones after fracture or similar trauma. A clinical and experimental study.


Increased susceptibility to proteolytic action of gastric superficial mucosa after sialic acid release.


Precision of RNA separation by polyacrylamide gel electrophoresis.


An ultrasensitive isotope dilution method for the determination of L-amino acids.


Sepharose gel filtration method of purification of lipopolysaccharides.


Electroretinography and electro-oculography in diseases of the posterior pole of the eye.


The two site model of ribosomal function: a test using degenerate serine codons in bacteriophage f2 mRNA.


Glucose-6-phosphate dehydrogenase deficiency.


The role of the phagocyte in host-parasite interactions. 23. Relation of bactericidal activity to peroxidase-associated decarboxylation and deamination.


Oral iron therapy.

Oral iron therapy.


The osmotic fragility of human leucocytes in normal and in some pathological conditions.


Therapy of natural falciparum malaria with combinations of antifolic drugs in non-immune subjects.


Chloramphenicol acetylation in whole cells of Escherichia coli carrying R-factors characterization and kinetic studies.


Demonstration of the therapeutic effectiveness of sulfamethoxazole in experimental infections of mice.


A multipurpose microperfusion chamber.

A multipurpose microperfusion chamber.


Modification of nucleolar expression following laser micro-irradiation of chromosomes.


Phase-contrast cinematographic study of dissociated neurons from embryonic chick dorsal root ganglia cultured in the rose chamber.


In vitro primary immune response resulting from the interaction between bone marrow-derived and thymus cells.


Bacterial localization: the use of an autographic method for the study of infectious processes in mice.


Oxidative metabolism of the hypothalamus in hypophysectomized-castrated rats.


Biocmical and pharmacologic effects of L-asparaginase in man.


Pulmonary function after various periods of ischemia in the canine lung.


The outcome of antibiotic-soaked arterial grafts in guinea pig wounds contaminated with E. coli or S. aureus.


Management of aortic insufficiency complicating open mitral valve operations.


Posterior approach to correction of total anomalous pulmonary venous return. Further experience.


Current procedural terminology (CPT).

Current procedural terminology (CPT).


Ernst Adolph G.G. von Strümpell (1852-1925). Marie-Stmpell spondylitis.


Charles Rouget (1824-1904) successor to Claude Bernard.


Spatial interrelationship between craniocerebral reference points and basal ganglia.


Height of fourth ventricle. Normal variability during pneumography.


Delimitation of the ventral posterior nucleus of the thalamus. Comparison of radiologic and electrophysiologic techniques.


Normal relationship between basal vein and posterior cerebral artery.


Regional cerebral blood flow in patients with subarachnoid hemorrhage.


Effect of carotid and vertebral angiography on the cerebral circulation studied with intravenous isotopes. Preliminary report.


Ultrasonic encephalography.

Ultrasonic encephalography.


Discographic-anatomical correlation of developmental changes with age in the intervertebral disc.


Skin grafting in rats.

Skin grafting in rats.


Timely topics in microbiology: virology 1968-1969.


Bronchopulmonary derangements in nonsmokers.


To sigh or not to sigh.

To sigh or not to sigh.


Purification from calf thymus of an inhibitor of deoxyribonuclease I.


Mortality in lambs due to Salmonella typhimurium.


Normal bacterial flora of the porcine uterus.


Gustav Simon (1824-1876).

Gustav Simon (1824-1876).


On the mechanism of the pepsin-catalyzed exchange of carboxylic acids with water-18O.


An appreciation, on the occasion of his 90th birthday, of Academician K. I. Skrjabin: founder of the Soviet helminthological school.


Non-traumatic necrosis of the femoral head. II. Experiences in treatment.


Robert Wilkinson Johnson, Jr., M.D. 1891-1969.


Studies on tissue responses in primary and subsequent infections with Heterakis galinae in chickens and on the process of formation of caecal nodules.


The geelong disaster.

The geelong disaster.


Estimation of molecular size and molecular weights of biological compounds by gel filtration.


Automatic peptide chromatography.

Automatic peptide chromatography.


Application of optical rotatory dispersion and circular dichrosim to the study of biopolymers.


Free zone electrophoresis. Theory, equipment, and applications.


Location of arginine kinase in the cilia of Tetrahymena pyriformis.


Sex differences in survival of H-2 incompatible skin grafts in mice treated with antithymocyte serum.


Prolongation of skin graft survival using immune serum.


Antinucleolar antibodies. Their frequency and diagnostic association.


Effect of papaverine on regional blood flow in focal vascular disease of the brain.


Traumatic rupture of the innominate artery--a seat-belt injury.


A.N.A.

A.N.A.


Fate of cadaveric renal allografts.

Fate of cadaveric renal allografts.


A rapid and simple method for the detection and isolation of Salmonella from mixed cultures and poultry products.


Germinal centers and germinal center neoplasms.


Pathophysiological observations on porphyrias.


Simple disposable method for quantitative cultures of urine. A disposable kit was tested as a means of detecting significant bacteriuria by quantitative culture of urine. The total error in 3,563 specimens tested by five investigators was less than 1%. The method was very effective in differentiating significant bacteriuria, i.e., more than 100,000 bacteria per ml of urine from uninfected urine. In specimens from patients with urinary tract abnormalities who had mixed bacterial flora, the absolute numbers obtained with the dip-inoculum method had a 10% variation when compared to results obtained by calibrated loop or dilution pour plate methods. Therefore, the main utility of the kit is for screening and following patients after therapy. A significant delay in time between inoculation of the medium in the kit with the freshly voided urine and incubation of the kit to promote growth did not affect the reliability of the kit as a method of doing quantitative urine cultures to detect bacteriuria.


Lethal effects of electric current on Escherichia coli. An attempt has been made to use low-voltage alternating current to kill microorganisms such as Escherichia coli. The bactericidal effect depends on the energy passing through the suspension and on the time during which the cells are left standing in the medium after the treatment. Most of the toxicity is due to an indirect effect developed with unalterable electrodes in the presence of chlorides in the medium. This method might be applied to eliminate pollution of natural waters.


Positive fluorescent treponemal antibody reactions in diabetes. In a survey of 129 diabetic patients and 142 normal individuals, a significantly higher percentage of positive reactions in the fluorescent treponemal antibody-200 (FTA-200) test was found among diabetic patients than in the normal population. Absorption of all FTA-200-reactive sera with an extract of Reiter's treponeme eliminated most of the positive reactions in sera from diabetic patients, and three of the five positive reactions detected in sera from apparently normal subjects. On immunoelectrophoresis, precipitin bands developed most frequently between the Reiter sorbent and sera from diabetic patients positive in the FTA-200 test. Serum components responsible for FTA reactivity and precipitin reactions against the sorbent were resistant to treatment with mercaptoethanol, suggesting antibody of the IgG class. Cross-reacting antibodies produced in response to normal treponemal flora, and perhaps acquiring enhanced reactivity by means of nonspecific interacting substances in sera peculiar to the altered physiological state of diabetes, are suggested as possible causes of positive reactions of unabsorbed sera. No correlation could be made between age of the diabetic patient, treatment or duration of the disease, and FTA or precipitin reactivity of the patient's serum.


Relation of the heat resistance of salmonellae to the water activity of the environment. The effect of water activity (a(w)) on the heat resistance of eight strains of Salmonella was studied. Heat resistance of the organisms increased as the a(w) of the heating menstruum was reduced. Sucrose afforded the cells a greater degree of protection than did fructose, glycerol, and sorbitol. A direct correlation between a(w) and heat resistance could not be established over the range of a(w) levels tested in this study. There was variation among the strains of salmonellae in the magnitude of the increase in heat resistance as the a(w) level was reduced. All strains of Salmonella tested showed a greater increase in heat resistance than S. senftenberg 775W as the environment became drier. Washed cells had D values 25 to 75% lower than unwashed cells. Prior growth of the organisms in media with a reduced a(w) increased the heat resistance of the organisms when glycerol, but not when sucrose, was the controlling substance.


Formic hydrogenlyase induction as a basis for the Eijkman fecal coliform concept. Many Enterobacter species recovered from a relatively unpolluted freshwater stream had the capacity to produce gas from glucose, lactose, and formate at 44.5 C. Composition of the evolved gas was shown to be CO(2) and H(2), which suggested that the enzyme system formic hydrogenlyase functions as the basis for the Eijkman fecal coliform concept. It is postulated that there are at least two different and distinct biochemical types of Enterobacter in the natural aquatic environment: one that lacks an active formic hydrogenlyase at 44.5 C and is associated with the intestinal tract of man and certain animals, and another which possesses the active enzyme at the elevated temperature and is found in soil or on vegetation free from fecal pollution.


Ten-minute test for differentiating between Klebsiella and Enterobacter isolates. A 10-minute test, utilizing a urease paper-reagent strip (PATHO-TEC), for differentiating Klebsiella and Enterobacter species is described. By using a heavy suspension of organisms and 50 C temperature for incubation, 93% of Klebsiella strains (186/200) were positive and 95% of Enterobacter strains (190/200) were negative with this testing system. The rapid nature of the test (10 min), the facility with which it can be carried out, and the ease with which the strips can be stored and handled may make this a useful aid for the clinical microbiologist.


Action of diethylstilbestrol on staphylococci: further observations on the effect of resting cells. Diethylstilbestrol (DS) has been shown to be active against staphylococci and other gram-positive bacteria but not against gram-negative microorganisms. The present study extends these findings. Standardized suspensions of (14)C-labeled Staphylococcus aureus serotypes III and IV and Shigella flexneri were prepared and exposed to pharmacological concentrations of DS (1 to 20 mug/ml) under diverse environmental conditions; the cells were removed by membrane filtration and the presence of radioactive substances in release to the supernatant fraction was followed by standard radioisotopic techniques. Controls were exposed similarly to the hormone vehicle alone (buffer containing 2% ethyl alcohol). DS at bactericidal concentrations above 6 mug/ml caused significant leakage of cellular radioactivity of S. aureus labeled with (14)C-glucose and (14)C-glutamic acid within 1 to 4 hr after exposure to DS. Maximum leakage of radioactivity occurred under anaerobic conditions at 37 C. Absorption studies of (14)C-labeled DS indicated that the affinity of S. flexneri for DS is markedly less than that of S. aureus. This might be one reason for the resistance of gram-negative bacteria to DS.


Agar dish isopiestic equilibration method for controlling the water potential of solid substrates. Maintenance of substrate water potential in petri dishes is achieved by using vapor-pressure controlling, solute-amended agar gel discs attached to the inside of the top halves of the dishes.


Motile nocardoid Actinomycetales.

Motile nocardoid Actinomycetales. The properties of 42 strains of nocardoid (nocardioform) bacteria were compared. The results indicate that the organism previously called Nocardia turbata does not belong to the genus Nocardia nor does it fit into any of the previously described genera.


Microbiological assay and tissue distribution of beta-thioguanine deoxyriboside in mice. A sensitive, precise microbiological assay has been developed for the determination of tissue distribution of beta-thioguanine deoxyriboside, a new antitumor agent.


Congenital cystic malformation of the lung: its relation to hydrops and hydramnios.


Necrotizing encephalomyelopathy of Leigh. Neuropathological findings in 8 cases.


Controlled trial of phenobarbitone in neonatal jaundice.


Non-vitelline accessory enteric formations.


Effect of Solcoseryl on the survival of skin-grafts and the healing of donor sites in rats.


Transplantation of the liver in man.

Transplantation of the liver in man.


Immunological studies in Kaposi's sarcoma in Uganda. An evaluation of humoral and cellular immune mechanisms was performed on patients with Kaposi's sarcoma in Uganda. Antibody responses and immunoglobulin levels were normal in all patients studied. Nevertheless, a striking impairment in the delayed hypersensitivity response to dinitrochlorobenzene was noted in patients with the "malignant" type of tumour.


Reliable retraction technique for elastic impression materials.


Circulatory effects of hydrocortisone and protection against endotoxin shock in cats.


Thiothixene. Its range of therapeutic activity.


A comparative determination of side effects associated with the oral use of three anticholinergic-psychotropic drugs.


Double blind study of clopenthixol and chlorpromazine in acute hospitalized schizophrenics.


Clinical evaluation of a new psychotropic drug--molindone.


A semiautomated microtechnique for serial dilution antimicrobial sensitivity testing in the clinical laboratory.


Malignant lymphomas in transplantation patients: a review of the world experience.


Immunofluorescent study of circulating antibody in experimental allergic encephalomyelitis.


Requirement of a nonproliferating class of cells for generation of immune responses in cell culture.


Reduction of antileukemic and immunosuppressive activities of 5-azacytidine in mice by concurrent treatment with uridine.


Release and synthesis of luteinizing hormone and follicle-stimulating hormone in pituitary cultures in response to hypothalamic preparations.


Long-term inhibition of platelet functions by aspirin.


Regulation of bacteriophage lambda development by gene N: properties of a mutation that bypasses N control of late protein synthesis.


Bypassing a positive regulator: isolation of a lambda mutant that does not require N product to grow.


Studies of the proteins of contracted sheath of T-even coliphage.


Gel electrophoresis of the head proteins of T-even phage.


The UV sensitivity of some early-function temperature-sensitive mutants of phage T4.


Further studies on high molecular weight fowlpox virus DNA and its hydrodynamic properties.


Intergenic suppression of amber polynucleotide ligase mutation in bacteriophage T4.


A new complementation group of phiX-174.


Biotin transduction from a donor lysogenic for lambda deleted in the N cistron.


Extradural blockade with bupivacaine. A double blind trial of bupivacaine with adrenaline 1-200,000, and bupivacaine plain.


Renal transplantation. Anaesthetic experience of 100 cases.


Treatment of malathion poisoning. Experience of two cases in Sarawak.


When to remove the tube?

When to remove the tube?


Obituary.

Obituary.


Genetic studies of the transplantation antigens.


Fractures of the spine.

Fractures of the spine.


Use of a new rifamycin SV derivative in chronic urinary infections.


Charles Baker.

Charles Baker.


On the origin of the cancer cells.

On the origin of the cancer cells.


Radio-isotopes and regional blood flow.

Radio-isotopes and regional blood flow.


Cardiac output computation.

Cardiac output computation.


An assessment of the analgesic efficacy of oral pentazocine.


A report on the use of an hydroxyethylrutoside in symptoms due to venous back pressure and allied conditions in the lower limbs.


Clinical trial of Theograd.

Clinical trial of Theograd.


Corneal disease.

Corneal disease.


Dextran 70 in prophylaxis of postoperative venous thrombosis. A controlled trial. A controlled prospective trial was carried out in a group of 80 women undergoing gynaecological surgery and thought to be at risk of developing postoperative venous thrombosis. The patients, who had been randomly allocated to prophylaxis with either dextran 70 or warfarin, were well matched in age, weight and other predisposing factors.In the warfarin group, 12 out of 40 patients developed deep vein thrombosis, six of these episodes being classified as major and six as minor. In the dextran 70 group, 4 out of 40 patients developed deep vein thrombosis, all of them minor. The protective effect of dextran 70 is significantly better than that of warfarin (P<0.01) as used in the present study.


Bone marrow graft in man after conditioning by antilymphocytic serum. Allogeneic bone marrow grafts carried out after previous administration of antilymphocytic serum alone were attempted in 16 patients. Of these, six had acute myeloblastic leukaemia, four acute lymphoblastic leukaemia, and one a blast cell crisis in polycythaemia vera. Ten of these patients were in an overt phase of the disease and resistant to chemotherapy, while nine had complete agranulocytosis. In five of these patients erythrocyte and leucocyte antigenic markers demonstrated the establishment of the graft. One patient had thalassaemia major, and four others had aplasia of the bone marrow, in one case due to chloramphenicol poisoning and in another to virus hepatitis. The grafts were successful in the last two patients and transformed their clinical condition.No signs of early acute secondary disease were noted in any of the patients, either when the donor had been given antilymphocytic serum or when he was untreated. The grafts had no adoptive immunotherapeutic effect on the acute leukaemia. These observations have clearly shown that antilymphocytic serum has an immunosuppressive effect in man when it is used alone.


Chemical structure of tubular and glomerular basement membranes of human kidney. Isolation, purification, carbohydrate and amino acid composition.


Drowning. Its clinical sequelae and management.


The stability of a codon transfer RNA complex.


Pyruvate dehydrogenase of Escherichia coli K 12.


Partial purification and properties of acyl-CoA synthetase of Escherichia coli.


The present status of infectious mononucleosis: a selective review.


A new career as artist.

A new career as artist.


Prosthetic management and speech improvement in individuals with dysarthria of the palate.


Dental Laboratories accredited by JCADL.


Denture identification.

Denture identification.


Release study of sulfaethylthiadiazole (SETD) from a tablet dosage form prepared from spray-congealed formulations of SETD and wax.


Acute arterial injuries in Vietnam: 1,000 cases.


In memoriam Sir Terence Cawthorne, honorable L.L.D., honorable M.D., F.R.C.S., 1902-1970.


The use of ultrasound in the treatment of Ménière's disease.


A model for the study of tooth enamel by scanning electron microscopy.


Template activity of liver chromatin increased by in vivo administration of insulin. The hypothesis that insulin may serve as a derepressor of genetic information in the liver of diabetic rats has been tested by comparing the template activity for RNA synthesis of chromatin from liver of insulin-treated diabetic rats to that of chromatin from liver of insulin-deficient diabetic rats. The template activity of the chromatins of insulin-treated diabetic rats is found to be 28 per cent greater than that of chromatin from liver of diabetic rats not treated with insulin. Time course studies show that the template activity of liver chromatin of rats injected with a single dose of insulin reaches a peak at two hours, which is some hours before the appearance of a typical insulin-induced liver enzyme, glucokinase. We conclude that insulin derepresses genetic material of the diabetic liver genome that is repressed in the absence of insulin.


Formation of all stable RNA species in Escherichia coli by posttranscriptional modification. The kinetics of accumulation of the known stable RNA species (23S, 16S, and 5S rRNA and tRNA) in Escherichia coli C122 were monitored by polyacrylamide gel electrophoresis of purified cellular RNA, following termination of brief pulse labeling with (32)P-orthophosphate. Isotopically labeled stable RNA species appear only after a time lag, while total cellular RNA and the ostensible precursors to the stable RNA classes accumulate from the earliest times examined. It is concluded that all the known stable RNA species in E. coli are the products of posttranscriptional modification.


Transcription initiation in the histidine operon of Salmonella typhimurium. Evidence is presented for two natural transcription initiators positioned internally in the histidine operon of Salmonella typhimurium. They were detected using highly polar S. typhimurium his mutants as recipients for F' Escherichia coli his episomes. These intergeneric complementation tests provide a sensitive method for the detection of other initiators and of terminators. That at least part of the operator for the his operon lies distal to the transcription initiator is suggested by transduction analysis of a new highly polar mutant described in this paper.


Biochemical and genetic studies of recombination proficiency in Escherichia coli. I. Enzymatic activity associated with recB+ and recC+ genes. An adenosine triphosphate-dependent deoxyribonuclease activity has been detected in lysates of recB(+)recC(+) strains. Mutations in recB or recC lead to loss of this activity, suggesting that these two genes determine the nuclease activity. The over-all reaction in crude lysates digests native DNA to nucleoside monophosphates. Complementation between recB21 and recC22 in vivo leads to normal levels of ATP-dependent nuclease activity. No complementation in vitro has been detected. Mutations in a third recombination gene (recA) do not alter significantly the wild-type levels of this nuclease activity.


Dr. Thomas Pellet.

Dr. Thomas Pellet.


Apothecary jar inscriptions--their interpretation.


Old English apothecaries' drug jars.

Old English apothecaries' drug jars.


Clinical, metabolic and molecular consequences of genetic disorders of the pentose phosphate pathway.


Epidemiology of serum uric acid and gout: an example of the complexities of multifactorial causation.


Load carriage and lubrication in articular cartilage: occupational implications.


Methods of assessing physical stress at work.


Gastric blood flow and its distribution during indomethacin administration.


Cardiovascular effects of lifting and static effort.


The ileal segment as a bladder substitute in extensive operations for malignant conditions in the pelvis.


One year survival and function after heterotopic liver autotransplantation.


An improved ureteroileal conduit stoma.

An improved ureteroileal conduit stoma.


Techniques of total appendectomy.

Techniques of total appendectomy.


Surgery of the parathyroid glands.

Surgery of the parathyroid glands.


The contrasting role of strA and ram gene products in ribosomal functioning.


Streptomycin and ribosome conformation changes.


A unitary mechanism for the several effects of streptomycin on the ribosome.


Approaches to the genetics of Escherichia coli ribosomes.


The transfer RNA binding site of the 30 S ribosome and the site of tetracycline inhibition.


X-ray diffraction studies of crystalline transfer RNA.


5 S RNA and the assembly of bacterial ribosomes.


Transfer RNA crystals studied by x-ray diffraction.


A structural requirement for codon-anticodon interaction on the ribosome.


Physical and functional heterogeneity of E. coli ribosomes.


Interaction of tRNA with ribosomes--binding and release of tRNA.


A model of the functioning ribosome: locking and unlocking of the ribosome subparticles.


On the mechanism of coded binding of aminoacyl-tRNA to ribosomes: number and properties of sites.


Ribosomal conformation changes during subunit dissociation and reassociation.


Studies of ribosomal subunit exchange.

Studies of ribosomal subunit exchange.


An historical account of protein synthesis, with current overtones--a personalized view.


The in vivo distribution of bacterial polysomes, ribosomes, and ribosomal subunits.


Initiator protein dependent binding of messenger RNA to the ribosome.


An in vivo block in the initiation of protein synthesis.


Initiation of protein synthesis in Escherichia coli. II. Role of the initiation factors in polypeptide synthesis.


Initiation of protein synthesis in Escherichia coli. I. Purification and properties of the initiation factors.


Role of initiation factors in the translation of messenger RNA.


The role of an aminoacyl-tRNA-GTP-protein complex in polypeptide synthesis.


Some requirements and characteristics of the fragment reaction.


The peptidyl transferase activity of ribosomes.


Translocation, aminoacryl-oligonucleotides, and antibiotic action.


The nature of T-factor-guanine nucleotide complexes.


On the catalytic center of peptidyl transfer: a part of the 50 S ribosome structure.


Characterization of three proteins involved in polypeptide chain termination.


Nonsense triplets and mammalian transfer RNA.


Enzymatic hydrolysis of N-acyl-aminoacyl transfer RNAs.


Peptide chain termination, codon, protein factor, and ribosomal requirements.


Temperature-dependent suppression of UGA and UAA codons in a temperature-sensitive mutant of Escherichia coli.


Structure and function of ribosomes and their molecular components.


Studies on the assembly of ribosomes in vitro.


The aminoacyl tRNA-protein transferases.


Regulation of in vitro translation of bacteriophage f2 RNA.


Translational control of MS2 RNA cistrons.


Studies on the assembly of ribosomes in vivo.


Nascent bacteriophage-specific proteins on polysomes of E. coli cells infected with R17 bacteriophage.


Translation of R-17 RNA fragments.

Translation of R-17 RNA fragments.


In vitro synthesis of T4 glucosyl transferase.


Dynamics of synthesis, translation, and degradation of trp operon messenger RNA in E. coli.


In vitrosynthesis of alkaline phosphatase monomers directed by E. coli messenger.


Characterization of lysozyme messenger and lysozyme synthesized in vitro.


The chemical and genetic structure of bacterial ribosomes.


In vitro synthesis of T4 proteins: lysozyme and the products of genes 22 and 57.


Proteins associated with ribosomes in T4-infected E. coli.


A combined operation for glaucoma and cataract.


Uimate fate of successful corneal grafts done for endothelial dystrophy (Fuchs's).


Hereditary deep dystrophy of the cornea (polymorphous).


The surgical treatment of double-elevator paralysis.


In memoriam. William Lemuel Benedict, M.D.


In memoriam. Harry Eggers, M.D.

In memoriam. Harry Eggers, M.D.


Frederick Herman Verhoeff--personal recollections.


Martin Hayward Post, Jr., M.D.

Martin Hayward Post, Jr., M.D.


Summary of recent abstracts. 3. Malaria.


Incidence of herds infected with a neonatal calf diarrhea virus (NCDV).


Experimental auxiliary liver allotraplantation with special reference to biliary duct obstruction and hepatic arterial blood restriction of host liver.


Recognition and management of the diarrheal syndrome caused by nonbeta islet cell tumors of the pancreas.


Vagotomy, gastric blood flow, and hemorrhage from gastritis.


Effect of protease inhibitors on experimental peptic ulceration.


Isolation and description of a Moraxella from horses with conjunctivitis.


Esophageal atresia and tracheoesophageal fistula.


Maurice Sullivan, MD, 1903 to 1969.

Maurice Sullivan, MD, 1903 to 1969.


Polymorphous light erutpion and lupus erythematosus. Differential diagnosis by fluorescent microscopy.


Francis Alva Ellis, MD, Oct 3, 1899 to Dec 6, 1969.


Studies of the red pigmentary system.

Studies of the red pigmentary system.


A clinical study of bacteriological culturing in endodontics.


Quantitative studies on the arrangement of human metaphase chromosomes. II. Influence of the preparation technique on the association pattern of the acrocentric chromosomes.


Enzymatic modification of proteins. 3. Purification and properties of a leucyl, phenylalanyl transfer ribonucleic acid protein transferase from Escherichia coli.


Metabolism of 1,4-diaminobutane and spermidine in Escherichia coli: the effects of low temperature during storage and harvesting of cultures.


Aminoacylation of Escherichia coli valine transfer ribonucleic acid by Neurospora crassa phenylalanyl transfer ribonucleic acid synthetase in tris(hydroxymethyl)aminomethane hydrochloric acid and potassium cacodylate buffers. Effect of salts, dimethyl sulfoxide, ethanol, and 2-mercaptoethanol.


The amino acid sequence of a lambda type Bence-Jones protein. 3. The complete amino acid sequence and the location of the disulfide bridges.


Microtubules and filaments in the filopodia of the secondary mesenchyme cells of Arbacia punctulata and Echinarachnius parma.


Purification of adenosylmethionine decarboxylase from Escherichia coli W: evidence for covalently bound pyruvate.


A simple technique for tooth supported complete dentures.


The XYY karyotype and criminality: a review.


The doctor and his machines.

The doctor and his machines.


Why we are getting out of Medicare.

Why we are getting out of Medicare.


Annotated bibliography on ambulatory patient services and nursing in ambulatory services.


Antihuman lymphocyte globul. Simplified production procedure for human use. Preliminary report.


Biology of the mycobacterioses. The measurement of antibodies.


Biology of the mycobacterioses. Studies on glucose oxidation during the interaction of alveolar macrophages and bacteria.


Biology of the mycobacterioses. Experimental models for studying leprosy.


Control of the maxillary arch by primary bone graft in cleft lip and palate cases.


Long-term postoperative results of primary and secondary bone grafting in complete clefts of lip and palate.


Secondary mucous membrane advancement in bilateral cleft lip: a combined surgical-dental approach.


Problems of retention in abnormal circumstances.


Maxillary segmental stability in cleft lip and palate subjects.


Survival of bacteria in concentrated haemodialysis solution.


The Master two-step test. Some historical highlights and current concepts.


Anti-vaccination and syphilis.

Anti-vaccination and syphilis.


James Garnet Sleeman.

James Garnet Sleeman.


Secondary hyperparathyroidism and renal osteodystrophy in chronic renal failure. Analysis of 195 patients, with observations on the effects of chronic dialysis, kidney transplantation and subtotal parathyroidectomy.


Esophageal suture anastomosis. An experimental studyn piglets.


Effects of carbon dioxide and halothane on compliance and pulmonary resistance during cardio-pulmonary bypass.


Darwinian evolution of proteins.

Darwinian evolution of proteins.


Gene for improved nutritional value in barley seed protein. Genetically dependent 20 to 30 percent increase in lysine per 16 grams of nitrogen results in improved nutritional values in feeding trials with mice and rats. The recessive gene was selected from the World Barley Collection. Other amino acids are also influenced by the gene. Protein content segregates independently of the changed amino acid pattern. The gene putatively influences the matrix proteins, which characteristically adhere to the starch grains in meal preparations. The morphological character permits rapid microscopic screening of single seeds without affecting viability. Low yield is considerably improved by crossing and selection.


Coevolution of Escherichia coli and bacteriophages in chemostat culture.


Colicin-tolerant mutants of Escherichia coli: resistance of membranes to colicin E1. Colicin E1 blocks proline accumulation by membrane vesicles prepared from wild-type sensitive Escherichia coli. Two classes of mutant cells are unaffected by colicin. Vesicles from colicin-resistant strains are sensitive to colicin E1, whereas vesicles from colicin-tolerant strains are unaffected by colicin El. These results suggest that the colicin E1 receptor is on the cell membrane and that colicin-tolerant strains have altered membranes while colicin-resistant strains have altered cell walls.


Differences in the action of nitrosomethylurea and streptozotocin.


Characterization of bacteriophages from nephritogenic group A streptococci.


Alteration of native DNA transcription by the mutagen hydroxylamine.


The metabolic and phagocytic activities of leukocytes from children with acute leukemia.


Comparative effects of fluphenazine, fluphenazine-chlordiazepoxide and fluphenazine-imipramine.


Synthesis and microbiological properties of some substituted derivatives of 3-amino-3,4-dihydrocarbostyril.


Methodologic investigations and prevalence of genital mycoplasmas in pregnancy.


Influence of lipophilic character on the antibacterial activity of cephalosporins and penicillins.


Body consciousness in states of pharmacological depression and arousal.


Beta-alanyl thio esters.

Beta-alanyl thio esters.


Effects of ethanol on the liver.

Effects of ethanol on the liver.


Nutrition, geography, and liver diseases.


Malabsorption in cirrhosis.

Malabsorption in cirrhosis.


Vitamins and liver injury.

Vitamins and liver injury.


Physicochemical studies on the minicircular DNA in Escherichia coli 15.


Biochemistry and regulation of streptomycin and mannosidostreptomycinase (alpha-D-mannosidase) formation.


Nucleic acid and protein content of purified endosymbiote particles of Paramecium aurelia.


Biology of the sugar-fermenting Sarcinae.


The enzymatic synthesis of poly 4-thiouridylic acid by polynucleotide phosphorylase from Escherichia coli.


Selective modification of 4-thiouridylate residue in Escherichia coli transfer RNA with cyanogen bromide.


Polyamines and protein synthesis. V. Effect of salt solutions on aminoacyl transfer RNA formation.


Structure of Escherichia coli ribosomes: effect of ribonuclease on the 30-S and 50-S subunits.


Thermal stability of ribosomes and RNA from Thermus aquaticus.


The inality of polyamines to maintain ribosome structure and function.


Chemical evidence for the presence of inosinic acid in the anticodon of an arginine tRNA of Escherichia coli.


Similarity of Tetrahymeana and mammalian RNA polymerases based on rifampicin resistance.


Lysozyme synthesis in Escherichia coli B cells infected with Phage T7.


Effect of tryptophan starvation on the rate of translation of the tryptophan operon in Escherichia coli.


Regulation of ribose metabolism in Escherichia coli. I. The ribose catabolic pathway.


Regulation of ribose metabolism in Escherichia coli. II. Evidence for two ribose-5-phosphate isomerase activities.


Regulation of ribose metabolism in Escherichia coli. 3. Regulation of ribose utilization in vivo.


Contamination hazards in multiple dose containers for injections.


Control of isoleucine, valine and leucine biosynthesis. 8. Mechanism of growth inhibition by leucine in relaxed and stringent strains of Escherichia coli K-12.


Cross-adaptation.

Cross-adaptation.


Genetic transfer and bacterial taxonomy.


A practical approach to automated diagnosis.


Laboratory tests for rubella and their interpretation.


Adrenochrome monosemicarbazone sodium salicylate complex and blood loss. Report of negative results.


Stabilization of isoleucyl-tRNA synthetase from yellow lupin seeds by transfer RNA.


Studies on the thymus of the Nile teleost fish, Clarias lazera C. and V.


Studies on the adrenal glands and corpuscles of Stannius of the teleost Nile fish, Clarias lazera C. and V.


Suppression of the development of primary antibacterial immunity by heterologous anti-lymphocyte serum.


Cardiac catheterization findings at rest and after exercise in patients following cardiac transplantation.


Simultaneous determinations of cardiac output by thermal dilution, fiberoptic and dye-dilution methods.


Bacterial endocarditis following open heart surgery.


Blepharoptosis repair by modified Fasanella-Servat operation.


Nontraumatic leukomas.

Nontraumatic leukomas.


Shigella sonnei corneal ulcer.

Shigella sonnei corneal ulcer.


Presidential address. Medical schools of Southern United States, 1779-1830.


Postoperative respiratory insufficiency: physiological studies with therapeutic implications.


Infected arterial grafts: experince in 22 cases with empsis on unusual bactia and technics.


Hemodynamic effects of arteriovenous shunts used for hemodialysis.


Multiple forms of L-asparaginase.

Multiple forms of L-asparaginase.


Effects of amphetamine derivatives on brain dopamine and noradrenaline. 1. Intracisternally administered metaraminol, alpha-methyl-octopamine, alpha-methyl-m-tyramine, and alpha-methyl tyramine were found to lower brain noradrenaline without having an effect on brain dopamine.2. Amphetamine, mephentermine, and norephedrine had no effect on brain catecholamines after intracisternal injection.3. There was no reduction in brain dopamine content after intracisternal injection of alpha-methyl-m-tyramine, yet the resulting brain concentration of alpha-methyl-m-tyramine was several times higher than after intraperitoneal injection of alpha-methyl-m-tyrosine, which decreased brain dopamine.4. The decreased synthesis of labelled catecholamines from (14)C-tyrosine after alpha-methyl-m-tyrosine suggested that this compound inhibits tyrosine hydroxylase in addition to its action of displacing brain amines.


Transformation of surface relief in skin flaps transplanted to sites with different functional leading.


60th birthday of Professor Dr. Jan Hromada, DSc.


The value of early rehabilitation in stroke.


The prevalence and incidence of Parkinson's disease.


Surgery in arthritis.

Surgery in arthritis.


Graft technique for anal stenosis.

Graft technique for anal stenosis.


Renal cysts: a survey.

Renal cysts: a survey.


Suggested pathophysiological principles for the prevention of ischaemic heart disease.


Kinetics of in vitro initiated secondary anti-hapten response: induction of plaque-forming cells by soluble and particulate antigen.


The blood-brain barrier to proteins under normal and pathological conditions.


Some morphological considerations of the blood-brain barrier.


On cerebrospinal fluid immunoglobulin-G (IgG) quotients in multiple sclerosis and other diseases. A review and a new formula to estimate the amount of IgG synthesized per day by the central nervous system.


Cross-reactions between streptococcal M proteins and human transplantation antigens. Allogeneic antiserums against human lymphocytes were specifically inhibited by M protein from beta hemolytic group A Streptococcus pyogenes, type 1. Analogous M proteins from streptococcus types 3, 4, 5, 6, 12, and 14 had little or no inhibitory activity. The specific inhibition by M protein is not a result of anticomplementary activity or of coating of the lymphocyte surface. Streptococcal polysaccharide and 73 other polysaccharides were inactive. Because all seven HL-A specificities tested were inhibited, it is inferred that M1 protein has a structure common to human histocompatibility antigens.


Insulin release from isolated human fetal pancreatic islets. Pancreases were obtained from five human fetuses 12 to 16 weeks old. The islets of Langerhans were isolated with collagenase, and then incubated with buffer, glucose, tolbutamide, or glucagon added to the medium. The insulin released into the medium was measured by immunoassay. Glucagon produced the only significant increase above base line; glucose and tolbutamide failed to enhance secretion of insulin. The data suggest that isolated human fetal islets of this gestational age develop responsiveness to glucagon earlier than to glucose or tolbutamide.


Marihuana and temporal disintegration.

Marihuana and temporal disintegration. High oral doses of marihuana extract, calibrated for content of 1 (-)-Delta(1)-tetrahydrocannabinol, significantly impaired the serial coordination of cognitive operations during a task that required sequential adjustments in reaching a goal. This disintegration of sequential thought is related to impaired immediate memory.


Classic pages in obstetrics and gynecology: George W. Corner and Willard M. Allen. Physiology of the corpus luteum. II. Production of a special uterine reaction (progestational proliferation) by extracts of corpus luteum.


Tubular polymers of normal human hemoglobin.


The history of witchcraft: a review with some psychiatric comments.


Uncle George and his Christmas tree.

Uncle George and his Christmas tree.


Modified radical mastectomy: why not?

Modified radical mastectomy: why not?


Tributes to George H Humphreys, II.

Tributes to George H Humphreys, II.


Water balance and extravascular lung water measurements in surgical patients.


Gastric defense mechanisms.

Gastric defense mechanisms.


Renal response to systemic trauma.

Renal response to systemic trauma.


In memoriam Dr. Herbert Conway.

In memoriam Dr. Herbert Conway.


Methohexitone and its application in dental anaesthesia.


The effect of single and repeated applications of hexachlorophane on the bacterial flora of the skin of the newborn.


Dermatology in Tudor and Early Stuart England.


Procaine amide-induced systemic lupus erythematosus.


Mycoplasmas and their association with skin disease.


Contact dermatitis X.

Contact dermatitis X.


Treatment of phobic states with antidepressants. A retrospective study of 246 patients.


A controlled study of polarization in depression.


Absence of brain antibodies in senile dementia.


Comparisons of hypnotic drugs.

Comparisons of hypnotic drugs.


Intrauterine thymectomy in the canine fetus.


Biorheology and blood flow.

Biorheology and blood flow.


An appreciation. A friend retires.

An appreciation. A friend retires.


A method for the three-dimensional study of pulmonary arteries.


Fifty years of Soviet pediatrics. Description and critical review.


Radioisotope scanning in experimenal lung transplantation.


The diagnosis of foot-rot in sheep.

The diagnosis of foot-rot in sheep.


Norepinephrine and dopamine injection into lateral brain ventricle of the rat and growth hormone-releasing activity in the hypothalamus and plasma.


A double-blind trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer. A controlled trial of carbenoxolone sodium positioned-release capsules (Duogastrone) was carried out on a randomized series of 100 unselected male Service personnel with symptoms of active duodenal ulceration and supporting radiological evidence. Fifty-seven patients completed the trial, 29 in the carbenoxolone group and 28 in the control group. The carbenoxolone group was given capsules containing 50 mg carbenoxolone four times a day for 12 weeks while the controls received a capsule identical in every respect except that it did not contain carbenoxolone. All patients were assessed at fortnightly intervals and had clinical and radiological reassessments three and six months after commencing treatment. Review at three months and at six months revealed a slight but clinically insignificant trend in favour of the carbenoxolone group. As a corollary to this controlled trial, those patients (38 in all) who did not have an early remission of symptoms were removed from the trial and placed on capsules known to contain carbenoxolone. Subsequently these patients did not show an advantage for carbenoxolone.


Evaluation of leukopenia in cattle.

Evaluation of leukopenia in cattle.


Clinical biostatistics. 3. The architecture of clinical research.


Clinical study of Duogastrone in the treatment of duodenal ulcers. This study confirms the preliminary reports that Duogastrone effectively controls the symptoms of duodenal ulceration and appears to hasten healing. In a double-blind trial, 14 patients with active duodenal ulcers were treated with Duogastrone capsules, one four times daily, half-an-hour before meals, while a comparable control group of 14 patients was treated similarly with a placebo containing magnesium trisilicate. Treatment continued for 12 weeks with clinical assessments fortnightly and a radiological assessment at the start and at the end of treatment. Only one of the 14 patients receiving Duogastrone did not respond. The remaining 13 showed marked clinical improvement with complete relief of pain and ceased to require supplementary antacids. Radiological evidence of healing or marked improvement was seen in eight of the 14 patients. None of the patients in the control group showed any marked improvement either of pain or tenderness and no changes were detectable by radiology. Patients in this group showed no reduction in their demand for supplementary antacids to relieve symptoms. No significant side effects were encountered. It is concluded that Duogastrone accelerates the healing of duodenal ulcer in ambulant patients and affords a much greater and more rapid relief of symptoms than does magnesium trisilicate.


Bovine lymphosarcoma.

Bovine lymphosarcoma.


Review of literature on diseases of the colon and rectum. September-October, 1968.


The effect of surrounding infection upon the healing of colonic wounds: experimental studies and clinical experiences.


Robert Thomson Leiper, 1881-1969.

Robert Thomson Leiper, 1881-1969.


Factors in male sexual inadequacy: a review.


Scanning malignant neoplasms with gallium 67.


Francis Rynd (1801-1861).

Francis Rynd (1801-1861).


Results of the leprosy programme in Japan in the past 60 years.


Composite skin contact smears: a method of demonstrating the non-emergence of Mycobacterium leprae from intact lepromatous skin.


A woman of parts (Florence Nightingale).


Lithane: the story of lithium carbonate.


Burnet of Australia.

Burnet of Australia.


The International Cardiovascular Society. North American Chapter. List of members, 1969-1970.


Too much to eat: coronary disease, 1769-1969.


Four chapters in the history of Australian cardiology.


Cardiac transplantation.

Cardiac transplantation.


Lymphocyte transformation in diseases of lymphoid tissue.


Rickets (and osteomalacia), nutritional and metabolic (1919-69).


Gastroenterology in Australia, 1949-69.

Gastroenterology in Australia, 1949-69.


Pulmonary mechanics and surfactant following re-implantation of dog's lung.


Prosthetic tracheal replacement.

Prosthetic tracheal replacement.


Pulmonary mechanics and surfactant measurement in canine lungs following reimplantation.


Hippelates flies and streptococcal skin infection in Trinidad.


Demonstration of "filopodia" formation by living trypanosomes.


A remarkable description of "Aleppo boil" in 1839.


XXV. Wherry memorial lecture. The ear and the eye in the Collected Workes of Ambroise Paré, renaissance surgeon to four kings of France.


Electron microscopy of Plasmodium falciparum.


A case of transfusion malaria due to Plasmodium falciparum with antibody studies of the donors.


Single proteins in the salivary glands of reduviid bugs.


Induced double infection with Plasmodium vivax and P. falciparum in a splenectomized chimpanzee.


An experimental study on the immunologic role of regional lymph nodes in the containment of malignant disease in man.


Transmission of human leprosy to the mouse and its clinical implications.


Results obtained in peforating keratoplasty with preserved corneas, using liquid nitrogen.


Manifestations of malignant lymphomas in the head and neck.


Analysis of the biological activity of antilymphocyte serum. II. Influence of cell type and method of immunization.


Effect of 32P chromium phosphate on immune reactions and phagocytic activity in rats.


Antiviral drugs.

Antiviral drugs.


Techniques and results with arteriograms in human renal allotransplants.


The Fernel-Paré medal.

The Fernel-Paré medal.


Orbital infusion of steroids in the rabbit.


László de Blaskovics. Hungarian ophthalmology celebrates his 100th birthday.


General procedure for crystallization of transfer ribonucleic acid.


Polyuridylic acid directed binding of phenylalanyl transfer ribonucleic acid to mammalian 40S ribosomal subunits.


Regulatory properties of phosphoribosyladenosine triphosphate synthetase. Synergism between adenosine monophosphate, phosphoribosyladenosine triphosphate, and histidine.


Biosynthesis of bacterial menaquinones. Origin of quinone oxygens.


The effect of oxygen tension on methylene hexadecanoic acid formation in Pseudomonas fluorescens and Escherichia coli.


Structural features of lipid A preparations isolated from Escherichia coli and Shigella flexneri.


Cell-free synthesis of ferredoxin in clostridial extracts.


Iproveratril and bronchial asthma.

Iproveratril and bronchial asthma.


Soluble antigen from sheep erythrocytes: preparation and antigenic properties.


Bacteriophage linked assays for antibodies to protein antigens.


In memoriam. Una Lucy Fielding, B.A., B.SC., M.B., CH.M. (University of Sydney).


The localization of end-plates in unstained muscle.


A method for the qualitative demonstration and quantitative estimation of esterases in the ox adrenal medulla.


Experimental observations on paraventriculo-hypophysial neurones.


The polar bodies of hamster eggs.

The polar bodies of hamster eggs.


Carboxyl-terminal sequence of human gastricsin and pepsin.


Control of beta-glucosyltransferase and lysozyme synthesis during T4 deoxyribonucleic acid-dependent ribonucleic acid-dependent ribonucleic acid and protein synthesis in vitro.


On the nature of the yeast phenylalanine tran- sfer ribonucleic acid synthetase recognition site.


Cell-free hemoglobin synthesis. II. Characteristics of the transfer ribonucleic acid-dependent assay system.


From the files of the Committee for the Study of Maternal Mortality.


An unusual case of nerve regeneration: report of case.


The People's Clinic.

The People's Clinic.


Dental caries--orthodontic appliances--SnF2.


Memoir.

Memoir.


Effects of desmethylimipramine and cocaine on the uptake, retention and metabolism of H3-tyramine in rat brain slices.


The histopathology of early approximal caries in the enamel of primary teeth.


Some effects on the conceptus of prior immunological sensitization of ewes to the sire.


Techniques to reduce the negative effects of high voltage electrical artifacts during averaged electroencephalic audiometry (AEA).


Ectodermal dysplasia: a case report.

Ectodermal dysplasia: a case report.


Management of two abscessed primary molars in a four-year-old child: report of interesting case.


Streptomycin-induced phenotypic suppression of hydroxylamine-induced nonsense mutants in the rII A cistron of bacteriophage T4. Twenty-one hydroxylamine-induced rII A cistron nonsense mutants were tested for streptomycin (SM)-induced phenotypic suppression by exposing Escherichia coli SBO (nonpermissive host) to phage in the presence and absence of SM. All nine amber, four of six ochre, and five of six opal mutants were phenotypically suppressible by SM. For suppressible mutants, the ratio of the average burst size in the presence of SM to size in the absence of SM ranged from 12 to 242 for the ambers, 3 to 33 for the ochres, and 4 to 14 for the opals. Increased susceptibility of the amber mutants to SM-induced phenotypic suppression relative to the susceptibility of the opal and ochre mutants may reflect a neighboring base effect, such that a 3'-terminal adenine inhibits misreading of a 5'-terminal uracil.


Studies on the in vitro assembly of bacteriophage phi 80 and phi 80-lambda hybrids. Suppressor-sensitive (sus) mutants of bacteriophage phi80 defective in late functions were classified, by means of in vitro assembly tests, into two complementation groups: head donors and tail donors. Each group of mutants was subdivided, by means of two-factor crosses, into six cistrons. Deletion mapping revealed clustering of tail and also of head cistrons. The two clusters were located in the left arm of vegetative phi80 (the tail specifying cluster being distal). In vitro cross complementation between phi80 and lambda sus mutants revealed that whereas lambda heads could quite efficiently bind phi80 tails to form viable phage, the union of phi80 heads and lambda tails was very much less efficient. Deletion mapping of the phi80 sus mutants, using both phi80 and i(phi80)h(lambda) deletion lysogens indicated congruent gross gene arrangement in the two related bacteriophages.


Editorial. R.S.V.P.

Editorial. R.S.V.P.


Multiplication of bacteriophage P22 in penicillin-induced spheroplasts of Salmonella typhimurium. The spheroplasts of Salmonella typhimurium (LT2) prepared by treatment with penicillin were capable of adsorbing phage P22 C(1). The normal multiplication of the phage took place, although the burst size was reduced to one-fourth of that in intact cells. Rate of incorporation of (14)C-thymidine into spheroplasts was increased severalfold on phage infection. Multiplication of C(+) also took place, but no lysogeny could be established in spheroplasts. Furthermore, spheroplasts prepared from cells lysogenized with wild-type phage, LT2 (C(+)), and a temperature-inducible C(2) mutant, LT2(tsC(2)), were not inducible. Unlike normal cells, both mitomycin C and actinomycin D interfered with the phage multiplication in spheroplasts. The spheroplast system offers great advantages in the study of the synthesis of nucleic acids and proteins in phage-infected LT2.


Abnormal dentition in vitamin D resistant rickets. A case report.


Combined fluorescent-antibody and electron microscopy study of Marek's disease virus-infected cell culture. Duck embryo fibroblast (DEF) and chicken embryo fibroblast (CEF) cultures infected with Marek's disease virus were studied by combined fluorescent antibody and electron microscopy techniques. In both DEF and CEF cultures, cells containing immunofluorescent (IF) antigen also contained herpesvirus particles; conversely, cells lacking this antigen lacked herpesvirus particles. Two morphologically distinct IF antigens were detected in the cytoplasm. (i) A granular antigen in the perinuclear region was brightly stained with the conjugated antibody. This antigen was composed of a granular mass of osmiophilic material and did not contain virions. (ii) A diffuse antigen, present throughout the cytoplasm of infected cells, was less brightly stained. The area of the cell with the highest concentration of this antigen contained small vesicles, folded membranes, and fine electron-dense granules. Naked virions were occasionally seen in these areas. A diffuse nuclear IF antigen was occasionally seen in infected cells. This antigen was often separated from the nuclear membrane and the nucleolus by a clear margin. The intranuclear IF antigen was composed of a fine granular aggregate and naked herpesvirus particles which were randomly distributed throughout the nucleus. Viral capsids in antibody-treated cells were coated with fine filamentous material.


Studies with bacteriophage phi II. Events following infection of male and female derivatives of Escherichia coli K-12. We studied the course of infection of the female-specific bacteriophage phiII in male and female cells isogenic except for the presence of the substituted sex factor, F'lac. Both male and female cells are killed by phiII; however, only limited phage replication occurs in male cells. Host macromolecular synthesis stops abruptly at 4 to 6 min after infection of male cells, and synthesis of phage components cannot be detected. Experiments with chloramphenicol indicate that phage deoxyribonucleic acid (DNA) penetrates into male cells, since protein synthesis after infection is required to stop synthesis of DNA in males. Phage DNA becomes membrane-associated in both female and male cells. In male cells, parental phage DNA does not dissociate from the membrane during the latent period as is the case with females, indicating a block in phage DNA replication. Isolation of nonrestricting F'lac mutations indicates involvement of a specific episome product in phiII restriction.


Management of endodontic emergencies.

Management of endodontic emergencies.


Andre-Victor Cornil (1837-1908).

Andre-Victor Cornil (1837-1908).


Carl Thiersch (1822-1895), Leipzig surgeon.


Daniel LeRay Borden, M.D. (1887-1969).

Daniel LeRay Borden, M.D. (1887-1969).


Properties of the deoxyribonucleic acid contained in the defective particle coliphage 15. Escherichia coli strain 15 TAU, which requires thymine, arginine, and uracil for growth and harbors an apparently defective prophage, was induced by exposure to ultraviolet light (580 ergs/mm(2)) or to mitomycin C (5 mug/ml). Phage particles (coliphage 15) were recovered from the resulting lysate by treatment with deoxyribonuclease, filtration, and several cycles of differential centrifugation. Analysis of the phage particles obtained by using cesium chloride density gradient centrifugation in a preparative ultracentrifuge resulted in the resolution of three components. The major component had a peak density of 1.52 to 1.53 g/cm(3) followed by components with densities of 1.5 and 1.49 g/cm(3). The guanine plus cytosine content of coliphage 15 deoxyribonucleic acid (DNA) was determined by both analytical ultracentrifugation in cesium chloride and by thermal denaturation in standard saline citrate buffer. Respective values of 46.4 +/- 1% and 46.6 +/- 1% guanine plus cytosine content were obtained. Coliphage 15 DNA formed molecular hybrids with messenger ribonucleic acid (RNA) from both uninduced and ultraviolet-induced cultures of E. coli 15 TAU, but did not hybridize with E. coli ribosomal RNA. The molecular weight of coliphage 15 DNA was determined by constant velocity sucrose density gradient centrifugation to be about 33 x 10(6) daltons.


Interaction between guanosine derivatives and factors involved in the initiation of protein synthesis.


Size distrbution of polypeptide chains in cells.


Ribonuclease V of Escherichia coli requires ribosomes and is inhibited by drugs.


Ultrastructure studies of conjugating Escherichia coli.


Fluorescent treponemal antibody-absorption test reactions in lupus erythematosus.


Lower esophageal ring. 1.

Lower esophageal ring. 1.


Hand-Schüller-Kay-Christian disease and Kay's triad.


The treatment of traumatic avulsion of skin of the extremities.


Janet Howell Clark (1889-1969).

Janet Howell Clark (1889-1969).


Dr. John W. Gowen (1893-1967).

Dr. John W. Gowen (1893-1967).


Franklin Chambers McLean (1888-1968).

Franklin Chambers McLean (1888-1968).


Wilson Stuart Stone (1907-1968).

Wilson Stuart Stone (1907-1968).


Acute effects of a new potassium-sparing diuretic, amiloride hidrochloride (MK-870), alone and in combination with acetazolamide in normal human subjects.


E. Richard Weinerman, M.D.

E. Richard Weinerman, M.D.


A selected public health bibliography with annotations.


Technique of uretero-esophageal anastomosis for renal transplantation in cattle.


Hidradenitis suppurativa of the perineum: treatment by radical excision.


Total body potassium in infants. Determination by whole-body counting of radioactive potassium (40K).


Psychological aspects of the care of children with cystic fibrosis.


Influence of suture materials and technic on patency of anastomosed arteries of less than 1.5 mm. diameter.


Retention bars.

Retention bars.


Cortical hyperostosis in infants: a radiological study of  sixteen patients.


Oral laxatives in barium enema preparation.


The presence of Moloney virus induced antigen on antibody-producing cells.


Colonic preparation: a controlled trial of Dulcodos, Dulcolax and Senokot DX.


Left ventricular volumes in ischaemic heart disease.


The bladder volume in dogs following removal of vesical mucosa.


Frère Jacques Beaulieu (1651-1714).

Frère Jacques Beaulieu (1651-1714).


Ultrastructure of neuronal nucleoli of rat trigeminal gnglia: comparison of routine with pyroantimonate-osmium tetroxide fixation.


On the substructures of secretory granules of the chick beta islet cell.


Management of moderate longitudinal arrest of development of the ulna.


Ununited fractures of the middle and upper humerus. Special problems in treatment.


The present status of calciphylaxis and calcergy.


The classic: the state of calcium in the fluids of the body. I. The conditions affecting the ionization of calcium. Franklin C. McLean and A. Baird Hastings.


Massachusetts medical society.

Massachusetts medical society.


Radionuclide coronary angiography and myocardial blood flow.


Quantification of image studies obtained with a scintillation (Anger) camera.


Quantitative analysis of liver scan data as an aid to diagnosis.


Digitization of ultrasonic images.

Digitization of ultrasonic images.


The anatomic basis of parathyroid venous sampling.


Phlebectasia of the jugular and great mediastinal veins.


Excretory urography in the evaluation of renal transplants.


Renal transplant size measured by reflected ultrasound.


Robert Allen Powers, M.D., 1893-1970.

Robert Allen Powers, M.D., 1893-1970.


Elizabeth Florence Focht, Ph.D., 1914-1969.


Transplantability of leukaemia from leukaemic mice after irradiation and injection of allogeneic spleen cells.


Interferon and cancer: therapeutic prospects.


Marihuana chemistry.

Marihuana chemistry.


Transplantation: pairing of donor and recipient.


Ribonuclease V of Escherichia coli: susceptibility of heated ribosomal RNA and stability of R17 phage RNA. Native ribosomal RNA anid inttact pliage R17 RNA are insensitive to attack by ribonuclease V, an exonucleolytic activity associated with ribosome movement on the substrate RNA. However, ribosomal RNA becomes a substrate when it is heated under conditions that make it a template for protein synthesis, and R17 RNA is attacked if it is either heated or fragmnented. Accessibility of the 5' terminus of an RNA molecule is probably inzcreased by heating or fragmnentation and may determine its susceptibility to ribonuclease V.


Frequency-specific relation between hippocampal theta rhythm, behavior, and amobarbital action. The frequency of the hippocampal theta rhythm in freely moving rats varies predictably in relation to behavior in a simple learning situation. The theta rhythm may be driven by electrical stimulation of the medial septal area at frequencies within the theta range. The threshold for septal driving is lowest at that frequency which the rat displays in response to frustrative nonreward; the driving threshold is selectively raised at this frequency by sodium amobarbital. It is suggested that the behavioral effects of amobarbital are due to a disruption of the theta frequency normally displayed in response to nonreward.


The effect of morphine on blood pressure and cardiac output in patients with acute myocardial infarction.


Coronary occlusion treated with small doses of heparin.


Hypoglocosuria and L-forms of Escherichia coli in the urine.


Studies on Nosema cuniculi found in transplantable ascites tumours with a survey of microsporidiosis in mammals.


Mutarotation of sugars in solution. II. Catalytic processes, isotope effects, reaction mechanisms, and biochemical aspects.


In memoriam Eugene H. Weissenberg, M.D. 1892-1969.


Mediastinal emphysema following the use of a high-speed air-turbine dental drill.


H. Edward MacMahon, MD, MRCP, ScD.

H. Edward MacMahon, MD, MRCP, ScD.


Training in physical medicine in Great Britain.


Pathology of erythroblastic mitosis in occupational benzenic erythropathy and erythrema. In vivo and in vitro studies.


Incorporation of monoflurotryptophans into protein during the growth of Escherichia coli.


Response of gnotobiotic pigs to oral infection with an enteropathogenic and with an edema disease strain of Escherichia coli.


A review of early language development.

A review of early language development.


Pancreatic insulin secretion following intrapancreatic infusion of amino acid.


Intracellular responses to environmental change: the quest for optimum environment.


Radiation dose to the respiratory tract of uranium miners--a review of the literature.


Intestinal motor activity and blood flow.


Foley's Footnotes.

Foley's Footnotes.


Hillenbrand Fellowship established by ADA trustees.


The origin of circulating antibody-synthesizing cells in the rat.


J. J. Hiniker, ADA vice-president, dies.


Anticomplementary activity of gamma G-immunoglobulins and of their subunits.


Research in dental materials.

Research in dental materials.


Operation for improved retention of the lower denture.


Subunit structure of L-ribulokinase from Escherichia coli.


The pyruvate-aspartic semialdehyde condensing enzyme of Escherichia coli.


Purification of five serine transfer ribonucleic acid species from Escherichia coli and their acylation by homologous and heterologous seryl transfer ribonucleic acid synthetases.


Properties of an aggregate ribonucleic acid polymerase from rat thymus and its response to cortisol injection.


A chronological list of Sir Walter Mercer's contributions to surgical literature.


Cells involved in the immune response. XIV. The immunologic response of irradiated rabbits given allogeneic bone marrow cells incubated with antigen and-or subjected to irradiation in vitro.


A new serum factor in normal rabbits. VI. Reaction with buried determinants of IgG exposed sequentially with CNBr, pepsin and papain.


The vascular determinants of reversible rejection.


Preservation and transplantation of dog organs maintained in vivo for 24 hours by mechanical ventricular assistance.


Effect of a single large dose local x-rays on allogeneic skin graft rejection in the mouse.


Successful human kidney transplantation after six hours of cadaver organ preservation by mechanical ventricular assistance.


Tuberculosis control--a new phase.

Tuberculosis control--a new phase.


Oral cancer; precision per oral cone therapy.


Effect of intraduodenal instillation of hydrochloric acid on plasma insulin levels of patients with portocaval shunts.


Early resuscitator.

Early resuscitator.


Scorbutic hemopericardium.

Scorbutic hemopericardium.


Purification and desiccation of Salmonella-polysaccharides by means of repeated alcohol-acetone precipitation.


Care of the critically ill child: major burns.


Research on the modified Picture Titles subtest of the IES test.


Chronic urinary tract infections in children: a double-blind study of medical management.


Perception bibliography. XLV. Psychological Abstract, 1933, volume 7.


Amoebiasis and intestinal protozoal infections.


Cardiac output and coronary blood flow in steady state exercise during steady state hypoxia.


Fatal pulmonary edema as a complication of acute falciparum malaria.


Epidemiologic and serologic investigations of filariasis in indigenous populations and American soldiers in South Vietnam.


Schistosomiasis mansoni in the chimpanzee. The natural history of chronic infections after single and multiple exposures.


Effect of epinephrine on coronary collateral blood flow following coronary artery occlusion.


Malignant lymphoma in the Saudi Arab.

Malignant lymphoma in the Saudi Arab.


Ultrastructure of ovarian tumors. I. Papillary serous cystadenocarcinoma.


Frequency function of transit times through dog pulmonary circulation.


Estimation of stroke volume in the dog by a pulse contour method.


Dual adrenergic and cholinergic innervation of the cerebral arteries of the rat. An ultrastructural study.


The autoperfusing heart-lung preparation. A vehicle for the preservation of the resuscitated cadaver heart.


In vitro interaction of nitrogen-containing heterocyclic compounds with Escherichia coli ribosomes: dissociation of 70S ribosome.


Survival and functioning of autoplastic, homoplastic and xenoplastic pituitary grafts in the red-spotted newt.


Histocompatibility studies in a closely bred colony of dogs. I. Influence of leukocyte group antigens upon renal allograft survival in the unmodified host. The establishment of a closely bred colony of beagles with known leukocyte group phenotypes has permitted an assessment of the role of leukocyte group antigens in conditioning the survival of renal allografts in the unmodified host. 22 kidney transplants obtained from leukocyte group-compatible donors were accorded a mean survival time of 25.5 days, as compared with 13.1 days for 27 transplants obtained from incompatible donors. Donor-recipient coefficients of correlation and Swisher erythrocyte group incompatibilities did not appear to affect the observed results. The mean survival time of 21 renal allografts performed in randomly selected mongrel dogs was 9.5 days. Availability of a carefully characterized and phenotyped canine population may be useful in further studies of the comparative immunogenicity of the major transplantable organs, and of methods designed to facilitate prolonged organ transplant survival in the mammalian host.


In vitro stimulation of antibody formation by peritoneal cells. II. Cell interactions and effects of immunochemical or metabolic inhibitors. Peritoneal cells (PC) from normal, unimmunized mice were placed in ultra-thin monolayer cultures containing carboxymethylcellulose (CMC), sheep red blood cells (SRBC), and complement, and tested for the appearance of plaques of lysis. The behavior of PC from young male mice and from female mice that had given birth to several litters (retired breeder mice) was studied. It was found that cells from spleen, mesenteric lymph node, thymus, bone marrow, thoracic duct lymph, or Peyer's patches could not form plaques in the CMC microcultures. Also, various combinations of these cells did not lead to plaque formation. When cells from any of these sources were mixed with PC, there was either no effect or an actual inhibition of plaque formation, the plaque counts being lower than would have been expected from the number of PC present in the mixture. Optimal plaque formation by peritoneal cells was found to be dependent on an optimal cell concentration, this optimum being around 5 x 10(6)/ml for young male mice and 0.5 x 10(6)/ml for retired breeders. Inhibition of plaque formation was found with either supra- or suboptimal cell concentrations. The inhibition by excess cell concentration may have been a simple nutritional or nonspecific overcrowding effect, as it could also be induced by an addition of an excess of spleen or lymph node cells. The failure of more dilute PC preparations to give adequate numbers of plaques appeared to be more specific, as plaque numbers could not be restored to normal by addition of spleen cells. The suggestion was that some cell to cell interaction between PC was involved. This dependence on cell concentration was not seen with immunized spleen PFC. Plaque appearance could be specifically and reversibly suppressed by placing PC in a medium containing rabbit anti-mouse IgM serum. Anti-IgG serum had no such effect. These experiments strengthened our view, expressed in the accompanying paper, that plaque formation was due to the formation of IgM, hemolytic antibody to SRBC by the PC. Metabolic inhibitors were incorporated into monolayer cultures and had different effects with the different types of PFC used. In the case of spleen cells from mice actively immunized against SRBC 4 days before killing, actinomycin D had no effect on plaque counts and puromycin reduced plaque numbers by a factor of 2. In the case of PC from young male mice, actinomycin D in concentrations above 0.01 microg/ml caused reductions down to < 2% of control values in plaque counts, and puromycin (10 microg/ml) had a similar effect. The PC from retired breeder mice occupied an intermediate position between the two cases just discussed. A compartment of cells, equal to about one-fifth of the total normal PFC compartment, was identified as resistant to high concentrations of either actinomycin D or puromycin, being similar in these respects to PFC from spleens of intentionally preimmunized mice. The mitotic poison, Colcemid, did not affect plaque counts in any situation tested. The theoretical implications of these results are briefly discussed.


In vitro stimulation of antibody formation by peritoneal cells. I. Plaque technique of high sensitivity enabling access to the cells. An improved method for the short-term culture of mouse peritoneal cells in a medium containing carboxymethylcellulose (CMC), sheep erythrocytes (SRBC), and guinea pig complement is described. It involves preparation of microcultures, of thickness 12-15 micro and volume 3.6 microl, under paraffin oil. With such cultures, peritoneal cells from normal, unimmunized young male CBA mice give about 3000 hemolytic plaques per million cells cultured, this figure being attained within 24 hr. The plaque detection method is about four times as sensitive as the Jerne technique. A method is described whereby such plaque-forming cells (PFC) can be transferred, by micromanipulation, to fresh monolayer cultures containing SRBC, CMC, and complement. In this fashion, the secretory capacity and susceptibility to inhibitors of peritoneal PFC can be tested in detail. Using this technique, evidence is presented that the hemolytic substance responsible for plaque formation is actually secreted by the cell at the center of the plaque, and is not a complement component but probably an antibody. Studies on the time of plaque appearance after cell transfer, and the subsequent growth rate of the zone of hemolysis, have been performed. They speak against the idea that the PFC is either a reservoir of cytophilic antibody or a "background" PFC. Rather they suggest that active antibody secretion is induced in the cell at some defined time point in culture. Detailed kinetics of the rate of appearance of plaques in peritoneal cell cultures revealed an exponential phase lasting from about 3 to about 13 hr with a doubling time of 2 hr. The reasons for this are not known. A greatly heightened reactivity was shown in peritoneal cells of mice that had been pregnant several times. Cultures of such cells showed more rapid plaque appearance and a peak activity about 20 times higher than with cells from young male mice. Cultures in which 1 cell in 10 formed a plaque were not infrequent. A series of experiments on germ-free mice showed reactivity similar to that of conventional mice from the same strain and source. The significance of the findings for cellular immunology are discussed.


The role of the lymphatic system in the rejection of homografts: a study of lymph from renal transplants. The rejection of renal homografts has been studied in sheep by transplanting kidneys into the neck and preserving the renal lymphatic drainage intact. Chronic fistulae were established in the transplanted renal lymphatics and lymph collected throughout the life of the graft. The changes that occurred in homografts during the process of rejection were reflected in changes in the lymph. Large numbers of basophilic, blast, lymphoid cells appeared in the lymph, and lymph production in the grafted kidney increased 20-50 fold. Over a period of about 10 days, up to 60 g wet weight of lymphoid cells and up to 10 liters of lymph were collected from the graft. Within 24 hr of grafting, the host cells present in the renal lymph had become sensitized to the graft and transformed into blast cells when cultivated in Millipore chambers in vitro. When the cells leaving the graft during the first 18-48 hr were injected into distant nonstimulated lymph nodes of the host sheep, they evoked significant cellular and antibody responses in the nodes. Within the graft, the main pathological changes were found in the vascular endothelium and many of the peritubular capillaries become plugged with emboli comprised of blast cells. There was extensive infiltration of the renal parenchyma with lymphoid cells and evidence of their transformation and proliferation within the renal blood capillaries. When all the lymph and cells leaving the homograft were diverted from the body, there was a greatly decreased reaction in the regional prescapular lymph node, and no reaction in lymph nodes distant from the graft. In these circumstances, the survival of the graft was not prolonged, and it was rejected without involvement of the lymph nodes of the host. Humoral antibody was produced in the lymph node regional to the homograft within 48-60 hr of grafting. Antibody was not detected in the blood or in the renal lymph until near to the time the graft was rejected. It was thought that this was due to the binding of antibody by the kidney graft tissue. We conclude that all the events which lead to the recognition and rejection of renal homografts can occur centrally within the graft itself.


Specificity in bacterial protein synthesis: role of initiation factors and ribosomal subunits.


Cilia and bronchial clearance: the effects of pharmacologic agents and disease.


Excision-repair properties of an Escherichia coli mutant deficient in DNA polymerase.


DNA synthesis in vitro.

DNA synthesis in vitro.


The DNA replicating capacity of isolated E. coli cell wall-membrane complexes.


Effects of early postnatal lesions of the pituitary stalk and median eminence in rats.


Strain differences for preoptic stimulation of ovulation in cyclic, spontaneously persistent-estrous, and androgen-sterilized rats.


Computer processing of the roentgen image.


Principles and methods of skin grafting in burns.


Discriminant analysis on coagulation and fibrinolytic data obtained during liver homotransplantation.


Obituary--Paul M. Aggeler.

Obituary--Paul M. Aggeler.


Limb replantation. An experimental model.


Exfoliative cytopathologic studies in organ transplantation. 3. The cytologic profile of urine during acute renal allograft rejection.


Normal human cervical squamous epithelium in vitro fine structural differences from in vivo cells.


Antineoplastic principles in plants: recent developments in the field.


The evaluation of present antileprosy compounds.


Advances in the chemotherapy of viral diseases.


Composition of bacterial cell walls in relation to antibiotic action.


The combination of gas chromatography and mass spectrometry in the identification of drugs and metabolites.


Heart disease screening of preschool children. Comparison of computer and physical examination methods.


Edwards A. Park (1876-1969).

Edwards A. Park (1876-1969).


Central nervous system damage in the human fetus and newborn infant. Mechanical and hypoxic injury incurred in the fetal-neonatal period.


Officers, boards, committees, and representatives of the American Psychological Association.


Distinguished Scientific Contribution Awards: 1969: Citation for Jean Piaget.


Stanley Schachter.

Stanley Schachter.


Herbert Alexander Simon.

Herbert Alexander Simon.


Dr. Sam. VII. Ups and downs. (Samuel Booth Sturgis).


Total reconstruction of the cervical trachea.


The fluorescein test in postirradiation surgery. A preliminary  report.


Effects of hypertonic stress on the fine structure of sickled erythrocytes.


Storage of platelet concentrates at 22 degrees C.


In memoriam: Ludwig Heilmeyer.

In memoriam: Ludwig Heilmeyer.


Primary cancer of the breast.

Primary cancer of the breast.


Plate technique for folate assay.

Plate technique for folate assay.


Depressive illness in a general practice. A demographic study and a controlled trial of imipramine. The distribution of 93 consecutive cases of depressive illness in a Surrey general practice was found to be non-random. Married women were at risk, while men and unmarried women were largely spared. Married women were prone to the disorder at any time in their lives, and relapse was frequent. There was some suggestion that divorced wives and wives of low social class were particularly predisposed to the disorder.Sixty of the patients took part in a double-blind controlled trial of imipramine. There was no evidence that the drug was superior to a placebo in inducing a remission. It is suggested that imipramine has become established in clinical practice on inadequate evidence and that there is a need for further trials.


Drugs for dysentery.

Drugs for dysentery.


Stereotactic cervical myelotomy.

Stereotactic cervical myelotomy.


'Meningoceles' and 'meningomyeloceles' (ectopic spinal cord). Clinicopathological basis of a new classification.


Repair of the sole.

Repair of the sole.


The assessment of gastric secretion in man.


Intraventricular infusions in acute and chronic rabbits. Application of the stereotaxic method of Monnier and Gangloff.


Sedative and stimulant compared in enuresis.


Lenin's final illness.

Lenin's final illness.


Experiences with antibiotic trials in chronic bronchitis.


Facilitated diffusion of oxygen and its possible significance; a review.


Structure of monocytes and macrophages.

Structure of monocytes and macrophages.


Endocytosis.

Endocytosis.


Macrophages and delayed-type hypersensitivity.


The function of macrophages in the immune response.


Prevention of gastroesophageal reflux after resection of the lower esophagus.


Evaluation of diverse plastic and cutis prostheses in a growing host.


Surgical venipuncture.

Surgical venipuncture.


The origins of gastroenterostomy.

The origins of gastroenterostomy.


Closure of persistent tracheal stomas.

Closure of persistent tracheal stomas.


The donor in human liver transplantation.


Detection of bronchial blood flow from earpiece dye-dilution curve.


[Manifestations of giant cell follicular lymphoma (Brill-Symmers disease)].


Quantitative measurement of protein in disc electrophoresis by direct ultraviolet absorbance.


Determination of 5,6-dihydrouridine in ribonucleic acid.


The uptake of exogenous peroxidase by the beta cells of the islets of Langerhans.


Effect of adenine nucleotide moiety of coenzyme A on phosphotransacetylase.


The effects of 5-azacytidine and 5-azauridine on protein synthesis in Escherichia coli.


The effect of membrane lipid unsaturation on glycoside transport.


Uridin-5-oxy acetic acid: a new minor constituent from E. coli valine transfer RNA I.


Spectrophotometric evidence for the formation of an Escherichia coli B B-12s methyltransferase.


The effect of electric current on rat tail tendon collagen in solution.


Ultrastructural aspects of human dentine decalcified with chromium sulphate.


Combination chemotherapy with nitrogen mustard, vincristine, procarbazine, and prednisone in lymphosarcoma and reticulum cell sarcoma.


Effect of chlorambucil on spermatogenesis in the human with malignant lymphoma.


Giant-cell tumor: a study of 195 cases.

Giant-cell tumor: a study of 195 cases.


Cytogenetic analysis in two cases of lymphoma. Comparison between lymphosarcoma and reticulosarcoma.