Determination of the carboxyl termini of proteins with ammonium thiocyanate and acetic anhydride, with direct identification of the thiohydantoins.


Reaction of tetranitromethane with sulfhydryl groups in proteins.


The possible involvement of peptidyl transferase in the termination step of protein biosynthesis.


Studies on template-active ribonucleic acid from nuclei of insect pupae.


L-asparaginase synthesis by Escherichia coli B.


Immunologic memory of phytohemagglutinin-stimulated lymphocytes.


The effect of leukocyte transfusions on experimental bacteremia in the dog.


Fatal transfusion malaria.

Fatal transfusion malaria.


Canynge Hall, 1933-1969 (a short history of the University of Bristol Public Health Department).


Electron microscopy of polymorphonuclear leucocytes.


Interactions in the skin.

Interactions in the skin.


Recent advances in the study of leucocyte emigration.


Regional variation in susceptibility to virus infections.


Nuclear magnetic resonance studies on the biochemistry of biopolymers.


The chemistry of amidrazones.

The chemistry of amidrazones.


The effect of anti-lymphocytic IgG on estab- lished autoallergic thyroiditis in rats.


Adoptive transfer of the diseases of New Zealand black mice to normal mouse strains.


Formalinized chicken red cell nuclei as a simple antigen for standardized antinuclear factor determination.


The Lordat case and its import on the theory of aphasia.


Investigation in the field of alkaloids.


Increased vascular permeability in the primary cutaneous allograft response in the rat.


Propranolol in the therapy of ischaemic heart disease with angina pectoris.


The amino acid sequence in the vicinity of the covalently bound adenylic acid in glutamine synthetase from Escherichia coli.


Alpha-keto acid dehydrogenase complexes. 13. Reaction of sulfhydryl groups in pyruvate dehydrogenase with organic mercurials.


Oscillation of generation times and the control of cell division.


Resistance of Escherichia coli and Salmonella typhimurium to carbenicillin.


Enzymatic synthesis of deoxyribonucleic acid. XXXII. Replication of duplex deoxyribonucleic acid by polymerase at a single strand break.


The effects of oxygen on the possible repair of dehydration damage by Escherichia coli.


Characterization of DNA of colicinogenic factor E1 in a providence strain.


The effects of antibiotics on the interaction of T-factor, aminoacyl-tRNA and ribosomes.


Lability of isocitrate dehydrogenase in Escherichia coli.


Transductional analysis of colicin E2 refractory mutants of Escherichia coli K12 in which refractivity is associated with recombination deficiency.


Sedimentation equilibrium of paucidisperse systems. Subunit structure of complemented beta-galactosidase.


Tertiary structure of Escherichia coli beta-D-galactosidase.


Frameshift revertant of Salmonella typhimurium producing histidinol dehydrogenase with a sequence of four extra amino acid residues.


Enzymic joining of polynucleotides. 8. Structure of hybrids of parental T4 DNA molecules.


Enzymic joining of polynucleotides. VII. Role of the T4-induced ligase in the formation of recombinant molecules.


Protein synthesis with Escherichia coli ribosomes altered in conformation by monovalent cations.


On the asymmetry of lambda integration sites.


Recombination in bacteriophage lambda. 3. Studies on the nature of the prophage attachment region.


The integration and excision defect of bacteriophage lambda-dg.


An iron-dependent modification of several transfer RNA species in Escherichia coli.


Transplantation of fetal kidney with placenta.


New procedure for determining the ability of micro-organisms to reduce nitrate and nitrite.


Practical diagnostic aids in the study of dyslipoproteinemias.


Some basic aspects of bone metabolism in relation to osteoporosis.


Current status of oral contraceptives.

Current status of oral contraceptives.


Current status of erythropoietin.

Current status of erythropoietin.


Glucagon in medicine: New ideas for an old hormone.


Proinsulin. The single chain precursor of insulin.


The effect of insulin on protein synthesis in muscle. An example of an approach to the mechanism of hormone action.


Cellular and subcellular basis of cardiac hypertrophy.


The cellular action of digitalis compounds.


The hemodynamic effects of myocardial infarction and results of therapy.


The many forms of mitral incompetence.

The many forms of mitral incompetence.


Electrical slowing of the heart and post-extrasystolic potentiation.


Tissue immunity and tissue typing.

Tissue immunity and tissue typing.


Biochemical and genetic studies with nitrate reductase C-gene mutants of Escherichia coli.


Unimpaired repressibility of transcription of the operator-proximal eighth of the first (E) gene of the tryptophan operon in Escherichia coli.


Different modes of loss of photoreversibility of mutation and lethal damage in ultraviolet-light resistant and sensitive bacteria.


The sow, her litter and the veterinarian.


The influence of a mutation to UV and x-ray sensitivity on the gamma-ray induction of reversion to prototrophy in E. coli.


The influence of chlortetracycline feeding on Salmonella typhimurium excretion in young calves.


Reaction rates and biological action of alkylating agents. Preliminary report on bactericidal and mutagenic action in E. coli.


An immediate effect of inhibition of DNA synthesis on cell division in a Lon strain of Escherichia coli.


Oxalic acid in plants and in nutrition.

Oxalic acid in plants and in nutrition.


Hunger and satiety.

Hunger and satiety.


Oilseed protein: present and future.

Oilseed protein: present and future.


The urgency of social action for health.


New APHA president.

New APHA president.


Sedgwick memorial medal for 1969.

Sedgwick memorial medal for 1969.


A selected public health bibliography with annotations.


The case of the vanishing Boston dentists. Professional directories in estimating health manpower.


Incision with primary suture in the treatment of acute puerperal breast abscess.


Eye changes after death.

Eye changes after death.


Treatment of obese non-diabetic patients with phenformin. A double-blind cross-over trial. The effect of 50 mg. of sustained release phenformin capsules administered twice daily was compared with a placebo as an aid to weight reduction in obese non-diabetic patients. Phenformin and placebo were administered alternately in two three-month periods.Weight loss on a 1,200-calorie diet was greater in the first three months than in the second three months regardless of treatment. There was no difference in weight loss between the phenformin and placebo groups in either the first or second three-month period. Serum cholesterol levels tended to fall in association with weight loss, but not apparently in relation to the size of the weight loss or to the treatment.


Looking for papers.

Looking for papers.


Closure of wounds.

Closure of wounds.


Synthesis of a fragment (pentapeptide) of E. coli acyl carrier protein apoprotein.


Development of goitre after methylthiouracil treatment of mice with hypothalamic lesions.


The use of immunofluorescence to detect milk proteins in lactating mammary glands of rats.


Experimental herpes simplex encephalitis: early neuropathologic changes.


Guide to state associations of licensed practical-vocational nurses and state boards of nursing for LPN-LVNs.


In memoriam; Arthur Weil, 1887-1969.

In memoriam; Arthur Weil, 1887-1969.


Studies on the improvement of treatment of habu (Trimeresurus flavoviridis) bites. 7. Experimental studies on the habu venom toxoid by dihydrothioctic acid.


Shear test for measuring bonding in cast gold alloy-porcelain composites.


Production of glomerulonephritis by antisera against the soluble antigen (tryptic digested ultrasupernatant substance) from various rat organs.


Clinical studies of dental cements. 3. Seven zinc oxide-eugenol cements used for temporarily cementing completed restorations.


Jay Frank Schamberg, M.D. (1870-1934). Medical scholar and founder of the independent American Pharmaceutical industry.


Gentamicin: antibacterial activity, clinical pharmacology and clinical applications.


Portrait of a leader: Lillian D. Wald.

Portrait of a leader: Lillian D. Wald.


Stereotactic thalamotomy.

Stereotactic thalamotomy.


Clinical studies of dental cements. IV. A preliminary study of a zinc oxide-eugenol cement for final cementation.


Effectiveness of a fungicide in combination with oxytetracycline as a pulp capping agent.


ADN programs accredited by the National League for Nursing--1970, Department of Associate Degree Programs.


An evaluation of two proteolytic enzymes and critique of the clinical study.


Autoradiographic evaluation of periapical responses to pulpal injury. II. Mature rats.


Clinical and basic research projects, their planning and support.


Preoperative oral rinsing as a means of reducing air contamination during use of air turbine handpieces.


Organ transplantation, ethical aspect.

Organ transplantation, ethical aspect.


The demography of primitive populations.


Neuronal soma and whole neuroglia of rat brain: a new isolation technique. Minced rat brain softened by treatment with trypsin is disrupted by filtration through nylon and steel meshes to produce a suspension of free-floating cells and debris. The cells are separated and purified by centrifugation on discontinuous sucrose gradients. Preparations of neuronal perikarya, retaining stumps of processes, so obtained are 90 percent pure and yield 33.6 x 10(6) cells per brain (3 milligrams, dry weight). The glial cells, apparently intact with extensive branched processess, are about 70 percent pure by weight and are obtained in a yield of 6.6 x 10(6) cells per brain (2 milligrams dry weight). The neurons are smaller and have less lipid than the glial cells.


William Beaumont's travels and the "Cholera Campaign" of 1832.


Population studies on southwestern Indian tribes. I. History, culture, and genetics of the Papago.


Plastic histology: study of surfaces of wet tissues by means of replicas.


Clinical entities in "uveitis". An approach to the study of intraocular inflammation.


Ultrastructural changes of retinal pigment epithelium in response to invading retinoblastoma.


The cut gut.

The cut gut.


From mental health to social action: clinical psychology in historical perspective.


Wernicke's sensory aphasia.

Wernicke's sensory aphasia.


Cerebral neoplasms associated with renal transplantation.


Effects of topically applied isoproterenol on aqueous dynamics in man.


The technique of induction heating (inductive coagulation) in stereotactic surgery.


Electrical and chemical stimulation of limbic structures within the temporal lobe. Clinical findings. Stereotaxic approach.


Design and use of a plastic ball and socket stereotactic instrument for surgery of the brain.


The structural and functional 'trinity' of the body, brain and behavior.


A mechanism for fluid shifts specific for the central nervous system.


Ernest A. Spiegel. A volume commemorating the fiftieth anniversay of his graduation.


The effect of age on the normal bacterial flora of the skin.


A history of Laura Bridgman--from American notes.


The normal flora of the human skin.

The normal flora of the human skin.


Development and implementation of a thesaurus for the visual sciences. A thesaurus has been developed to serve as the integrating unit for the computerized information storage and retrieval system of the Vision Information Center. The Center maintains records of information in the visual sciences which are available to the user in the forms of computer-assisted instruction, literature retrieval, and patient records. The numerical coding system used in the thesaurus permits seven levels of specificity; this specificity is required for depth of indexing, as well as to limit the retrieval to those bibliographic citations which are relevant to a highly specific search request. The flexible design of the thesaurus facilitates frequent revision and addition of new terminology.


Comparative analysis of epilepsy abstracts and a MEDLARS bibliography. Bibliographic retrievals on epilepsy prepared by MEDLARS and Excerpta Medica Foundation (EMF) monthly during 1968 were comparatively analyzed. EMF retrieved 1,116 citations with an average delay of 5.41 months, compared to 1,006 citations retrieved by MEDLARS with an average delay of 6.45 months. Differences in size of retrieval and delay between the systems were not significant. A total of 365 journals were represented, but a smaller group of ninety-one journals with citations in both retrievals formed a "core" of productive journals yielding over half the output of both systems. About 300 articles were cited in both searches, leaving 800 citations retrieved by EMF but not by MEDLARS and 700 citations retrieved by MEDLARS but not by EMF. Thus neither system was felt to provide comprehensive coverage of the epilepsy literature. Discrepancies in retrieval were found to be due primarily to indexing and retrieval procedures and not to coverage of different journals by the two systems.


Canadian Society of Laboratory Technologists.


Education for health sciences librarianship in the United States.


Computer application in clinical and cineangiographic studies.


Hyperbaric oxygen treatment.

Hyperbaric oxygen treatment.


Permuted partial phage within single bursts of Escherichia coli infected with a T4D mutant.


Suppression by gene substitution for the leuD gene of Salmonella typhimurium.


The detection of complementation map clusters by computer analysis.


Duodenal inhibition of gastric secretion by osmotic agents in normal subjects and patients with duodenal ulcer. Gastric secretion in man is inhibited by the presence in the duodenum of hyperosmolar and hypoosmolar solutions. Both acid and pepsin outputs are affected. There is no change in hydrogen, sodium, or potassium ion concentration in the gastric juice. Pepsin concentration, however, is reduced by all inhibitory stimuli. Inhibition is thought to act directly upon parietal and chief cells, and a possible basis for this mechanism is discussed. The response is similar in control subjects and duodenal ulcer patients; there is in particular no evidence of impaired inhibition in the ulcer group. An anomalous feature is the relatively small inhibition of acid output after hypertonic saline in control subjects compared with the duodenal ulcer patients.


An immunological approach to the diagnosis of rejection of liver transplants.


Mycoses of the alimentary tract.

Mycoses of the alimentary tract.


The relationship of pentagastrin-stimulated pepsin secretion to duodenal ulceration.


Histopathology of corneal edema.

Histopathology of corneal edema.


The production of indole by bacteria in vitro.


Penetrating keratoplasty.

Penetrating keratoplasty.


The professional concept--its history and meaning to health service.


Alloplastic implants in corneal edema.

Alloplastic implants in corneal edema.


Our new president.

Our new president.


Incorporation of 5-diazouracil-2-14C into ribonucleic acids of Escherichia coli during division inhibition. Radioactive diazouracil (DZU-2-(14)C) was rapidly incorporated into acid-insoluble material of Escherichia coli B. Isolated ribonucleic acid contained essentially all of the incorporated label, and this was solubilized by ribonucleases but not by deoxyribonuclease. A maximum of 45 to 50% of added label was incorporated at division-inhibitory and subinhibitory concentrations. Incorporation levels and filament-forming capacity were concomitantly depressed by preincubation of DZU in various medium components. The lower levels of incorporation brought about by preincubation were apparently related to an inherent instability or high reactivity of the DZU. The limit on incorporation of fresh DZU suggests the presence of geometrical isomers in the original DZU. The nature of these isomers and the reactivity of DZU are discussed in relation to its use in future cell division studies.


Nonoxidative pentose phosphate pathway in Veillonella alcalescens. Crude cell-free extracts of Veillonella alcalescens C1, an anaerobe unable to ferment glucose, were assayed for individual enzymes of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities were not detectable. Constituent enzymes of the nonoxidative limb of the pentose phosphate pathway were demonstrable. The presence of transaldolase, transketolase, phosphoribose isomerase, and phosphoribulose epimerase in this organism suggests a primarily biosynthetic role for these enzymes. It is postulated that ribose is synthesized from lactate in V. alcalescens C1 via a modified reversal of glycolysis and the nonoxidative limb of the pentose phosphate pathway.


Regulation of the Escherichia coli tryptophan operon by early reactions in the aromatic pathway. 7-Methyltryptophan (7MT) or compounds which can be metabolized to 7MT, 3-methylanthranilic acid (3MA) and 7-methylindole, cause derepression of the trp operon through feedback inhibition of anthranilate synthetase. Tyrosine reverses 3MA or 7-methylindole derepression, apparently by increasing the amount of chorismic acid available to the tryptophan pathway. A mutant isolated on the basis of 3MA resistance (MAR 13) was found to excrete small amounts of chorismic acid and to have a feedback-resistant phenylalanine 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase. Genetic evidence indicates that the mutation conferring 3MA resistance and feedback resistance is very closely linked to aroG, the structural gene for the DAHP synthetase (phe). Since feedback inhibition of anthranilate synthetase by l-tryptophan (or 7MT) is competitive with chorismic acid, alterations in growth conditions (added tyrosine) or in a mutant (MAR 13) which increase the amount of chorismic acid available to the tryptophan pathway result in resistance to 7MT derepression. Owing to this competitive nature of tryptophan feedback inhibition of anthranilate synthetase by chorismic acid, the early pathway apparently serves to exert a regulatory influence on tryptophan biosynthesis.


Mechanism of 3-methylanthranilic acid derepression of the tryptophan operon in Escherichia coli. 3-Methylanthranilic acid (3MA) inhibits growth and causes derepression of the tryptophan biosynthetic enzymes in wild-type strains of Escherichia coli. Previous reports attributed this effect to an inhibition of the conversion of 1-(o-carboxyphenylamino)-1-deoxyribulose 5-phosphate to indole-3-glycerol phosphate and a consequent reduction in the concentration of endogenous tryptophan. Our studies have shown that 3MA-resistant mutants linked to the tryptophan operon have a feedback-resistant anthranilate synthetase; mutants with an altered indole-3-glycerol phosphate synthetase were not found. 3MA or 7-methylindole can be metabolized to 7-methyltryptophan, and 3MA, 7-methylindole, and 7-methyltryptophan lead to derepression of the tryptophan operon. Furthermore, 3MA-resistant mutants are also resistant to 7-methylindole derepression. These results strongly suggest that the primary cause of derepression by 3MA is through its conversion to 7-methyltryptophan, which can inhibit anthranilate synthetase, thereby decreasing the concentration of endogenous tryptophan. Unlike 5- or 6-methyltryptophan, 7-methyltryptophan does not appear to function as an active corepressor.


Transplantation of the rabbit's patella.


Robert K. Lippmann, M.D., (1898-1969).

Robert K. Lippmann, M.D., (1898-1969).


Ultrastructure of the cell envelope of Escherichia coli B after freeze-etching. The cell envelope of Escherichia coli B was investigated with the freeze-etching technique. A considerable gain in visible structural detail over more conventional electron microscopic techniques was obtained. The inner surface of the plasma membrane revealed a smooth surface sparsely studded with particles measuring from 5 to 10 nm in diameter, whereas the outer surface of the plasma membrane showed many more particles of corresponding diameter. The freeze-etched cell wall appeared to be a multilayered structure. The innermost layer could be observed as a profile studded with closely packed elements of about 10 nm in diameter. External to this layer was a smooth surface bordering the outermost cell wall layer. When frozen in the absence of glycerol the outermost surface observed in the cell wall was smooth, but when grown in the presence of glycerol it had a "wavy" appearance with small particles attached to it. The observations support current concepts on the ultrastructure of the enterobacterial cell envelope.


Resistance of Escherichia coli to penicillins. VII. Purification and characterization of a penicillinase mediated by the R factor R1. The penicillinase mediated by the R factor R1 in Escherichia coli has been purified and characterized. The purification procedure contained the following three steps: spheroplast formation, chromatography of the spheroplast supernatant fluid on DEAE cellulose, and preparative polyacrylamide-gel electrophoresis. The protein obtained gave only one band in analytical polyacrylamide-gel electrophoresis. To obtain milligram quantities of the enzyme, gel filtration on Sephadex G75 was run before the last step in the purification. By gel filtration on Sephadex G75, the molecular weight was estimated as 22,000. The pH optimum, tested in universal buffer, was 7.0. The turnover numbers for benzylpenicillin, d-ampicillin, and 6-aminopenicillanic acid were 4.2 x 10(4), 6.3 x 10(4), and 2.2 x 10(4) moles of substrate hydrolyzed per min by 1 mole of enzyme, whereas the Michaelis constants were 100, 160, and 440 mum, respectively. Cephalosporins were much poorer substrates for the R1 penicillinase than were the penicillins. The turnover number for cephalosporin C, cephaloridine, and 7-amino-cephalosporanic acid were 2.4 x 10(3), 5 x 10(2), and less than 2 x 10(2), respectively. These properties show that the R1 penicillinase is quite different from the chromosomally mediated penicillinase of E. coli (11). However, the R1 enzyme resembles another R-factor penicillinase previously purified by Richmond and Datta.


On the character of forces of interaction between erythrocytes and bacterial sensitins. 2. An analysis of the role of electrostatic, hydrogen and hydrophobic interactions in the process of haemosensitization.


Participation of type antigen R in the immunofluorescence reaction of group B streptococci.


Hemodynamic effects of ventricular defibrillation. Hemodynamic responses to ventricular defibrillation were studied in anesthetized dogs. Observations were made on arterial, right atrial and left ventricular end-diastolic pressures, on cardiac output (dye dilution), heart rate, and right atrial electrocardiogram. Ventricular fibrillation was induced electrically with a bipolar electrode catheter placed in the right ventricle. Fibrillation was maintained for 15 or 30 sec and terminated with a 400 w sec capacitor discharge across the thoracic cage. Responses lasted 1-10 min after conversion and included a cholinergic and an adrenergic component. The cholinergic component was characterized by sinus bradycardia, periods of sinus arrest, atrioventricular block, and ventricular premature beats. The adrenergic component included increases in arterial pressure, in cardiac output, and in left ventricular stroke work at a time when left ventricular end-diastolic pressure was normal; there was no change in total peripheral resistance. The pH of arterial blood decreased slightly and pCO(2) increased but pO(2) and the concentration of lactate were unchanged. Bilateral vagotomy and intravenous administration of atropine blocked the cholinergic component, unmasked a sinus tachycardia, and accentuated the adrenergic component of the response. The latter was blocked by intravenous administration of propranolol and phenoxybenzamine.THESE RESPONSES WERE RELATED PRIMARILY TO CONVERSION OF VENTRICULAR FIBRILLATION RATHER THAN TO THE ELECTRICAL DISCHARGE OF COUNTERSHOCK BECAUSE COUNTERSHOCK WITHOUT VENTRICULAR FIBRILLATION CAUSED MORE TRANSIENT AND SMALLER RESPONSES THAN THOSE OBSERVED WITH DEFIBRILLATION: furthermore, the hemodynamic effects of defibrillation were augmented by prolongation of the duration of fibrillation. The results suggest that the cholinergic component of the response may be detrimental in that it favors spontaneous recurrence of fibrillation; on the other hand, the adrenergic component may be essential for conversion since only one of six dogs depleted of endogenous catecholamines with reserpine survived ventricular defibrillation.


Academian M.P. Chumakov--sexagenarian.

Academian M.P. Chumakov--sexagenarian.


Professor Karel Raska, M.D., Dr. Sc., corresponding member of the Czechoslovak Academy of Sciences--sexagenarian.


Neurosurgical biblio-index.

Neurosurgical biblio-index.


A study of the accuracy of the apposition of palatal tissues to complete dentures.


Designing occlusal rests using mathematical principles.


Combined electrosurgery and gingival retraction.


Experimental stress analysis of dental restorations. VII. Structural design and stress analysis of fixed partial dentures.


Modified pressure impression technique for edentulous patients.


A report on maxillary orthopedics in cleft palate treatment.


Effects on tissue fine structure of variations in colloid osmotic pressure of glutaraldehyde fixatives.


Garcia da Orta (1501-02?-1568), materia medica and pharmacognosy.


Evaluation of therapeutic efficacy of amantadine in patients with naturally occurring A2 influenza.


Some notes on quail poisoning.

Some notes on quail poisoning.


Respiratory tract injury: a guide to management following thermal and smoke injury.


Tuning forks to audiometers and back again.


History of treatment of spinal cord injuries.


Problems in the management of drowning victims.


Practical everyday uses for the computer in medicine: the role of the computer as a diagnostic aid in the surgical abdomen. Section A--pain in the RLQ of the abdomen.


Derivation of the secondary structure of 5S RNA from its binding of complementary oligonucleotides.


Biosynthesis of insulin in anglerfish islets.


Immunosuppression by L-asparaginase.

Immunosuppression by L-asparaginase.


Pharmacologic and physiologic aspects of anesthesiology.


Dr. Talbott retires from JAMA.

Dr. Talbott retires from JAMA.


Scorbutic heroes.

Scorbutic heroes.


Antibodies in cardiac rejection.

Antibodies in cardiac rejection.


Motion sickness.

Motion sickness.


Evolution of the electro-dermatome.

Evolution of the electro-dermatome.


Vertebrate slow muscle fibers.

Vertebrate slow muscle fibers.


Measurements of maxillary area in repair of unilateral clefts.


Rhinoplasty. A short description of one hundred cases.


Sensory deprivation in autoscopic illusion, and Joseph Conrad's "The secret sharer".


Stereotaxic coordinates of the brain of the golden hamster (Mesocricetus auratus).


Inter-scorer reliability of David's three projective measures of alienation.


Alienation syndrome among Catholic male undergraduates.


Improvements in demonstration of lining layer of lung alveoli by electron microscopy.


Methods for determination of O2 dissociation curves, including Bohr effect.


Ranks of donor-recipient histocompatibility for human transplantation. Correlation of leukocyte groups with skin and renal allograft survival indicates that ranks of histocompatibility based upon current genetic concepts of the HL-A system may provide an approach to the selection of optimally compatible subjects for clinical organ transplantation. Such ranks may be expressed as a net histocompatibility ratio (NHR) between prospective donors and recipients. The best clinical results have been when this ratio is of 0.5 to 1. Donor-recipient compatibility situations where the ratio was 0.25 or less have been associated with a high incidence of transplant failure, regardless of whether the organ source was a living, related donor or a cadaver donor.


Mixed lymphocyte reactions and tissue transplantation tolerance. The induction of tolerance of Lewis histocompatibility antigens in BN rats inoculated at birth with BNI Lewis F(1) hybrid bone marrow cells, as revealed by the prolonged survival of Lewis skin grafts, is accompanied by markedly decreased reactivity in the mixed lymphocyte interaction. Blood lymphocytes from animals inoculated with lymph node cell suspensions also display diminished proliferative reactivity to hybrid BN/Lewis cells in the interaction. However, these recipients are not tolerant of Lewis skin grafts. Blood lymphocytes from BN rats inoculated neonatally with Lewis thymocytes fail to display any level of unresponsiveness in vitro, and such animals are not tolerant of Lewis skin grafts. The results suggest that in rats skin and marrow cells have histocompatibility antigens that are absent or poorly expressed on lymph node cells and thymocytes.


Suture only technic for protruding ears.


Positive contrast ventriculography.

Positive contrast ventriculography.


The renogram and renal scintigram in clinical medicine.


The fibrin clot; a medium for supporting loose cells and delicate structures during processing for microscopy.


A syringe-filter for processing specimens through fluids used in plastic embedding.


A biopsy clamp for removal and fixation of muscle in electron microscopy.


Processing soft tissue for scanning electron microscopy: Simplification of the freeze-drying procedure.


The fusion of cells with one- and two-cell mouse embryos.


Plant proteins in the amelioration of protein deficiency states.


Nutritional aspects of gallstone formation with particular reference to alimentary production of gallstones in laboratory animals.


Nutritional properties of fish oils.

Nutritional properties of fish oils.


Appraisal of BC-105 in migraine prophylaxis.


Hysteria in childhood.

Hysteria in childhood.


Manic-depressive illness in children and effect of treatment with lithium carbonate.


The effect of decloxizine and ephedrine on the peak expiratory flow of asthmatic patients. A double blind study.


Neurophysiological mechanisms underlying the action of hypo- and hyperglycemia in some clinical conditions.


Changes in the size and shape of the lateral ventricles with formalin fixation.


Fine structure of islet-cell innervation in the pancreas of normal and alloxan-treated rats.


Organization of the spermatozoon of Agriolimax reticulatus, the grey field slug (Pulmonata, stylommatophora).


Attempts to determine the pathogenicity of avian E. coli strains.


The role of a soluble fraction and ribosomes in the fidelity of poly U translation in bacterial cell-free systems.


The homeostasis of glucose and free fatty acids.


Psychotherapeutic processes.

Psychotherapeutic processes.


Developmental psychology.

Developmental psychology.


Personality.

Personality.


The vestibular system.

The vestibular system.


Attention.

Attention.


Derived motives.

Derived motives.


Brain functions.

Brain functions.


Psychopharmacology.

Psychopharmacology.


Psychophysiological contributions to social psychology.


Conformational studies of immunoglobulin G and its subunits by the methods of hydrogen-deuterium exchange and infrared spectroscopy.


Identification of 2-acetamido-2-deoxy-D-galactose in bovine kappa-casein.


Cross-linked DNA as template in the synthesis of RNA in vitro.


The relation between the strong binding of spermine to polynucleotides and the conformation of polynucleotides.


Studies on the yeast nucleus. 3. Properties of a deoxyribonucleoprotein complex derived from yeast.


Two stages in the replication of bacteriophage lambda DNA.


Studies on the binding of tetracycline to ribosomes.


Formation of the complex between CCA-enzyme and transfer RNA.


Estrone stimulation of RNA synthesis in uterine nuclear preparations.


Kinetics and mechanisms of drug action on microorganisms. IX. Inhibitory action of lincomycin on Escherichia coli by microbial kinetics.


Carbenicillin and gentamycin in antibiotic combinations in vitro.


Replication of RNA viruses. X. Replication of a natural 6 s RNA by the Q-beta RNA polymerase.


A functional analysis of the rel gene in Escherichia coli.


Chromosome replication in Escherichia coli. II. Origin of replication in F- and F+ strains.


Level of messenger RNA transcribed from the histidine operon in repressed, derepressed and histidine-starved Salmonella typhimurium.


Cosegregation of a sex factor with the Escherichia coli chromosome during curing by acridine orange.


An x-ray crystallographic study of Escherichia coli glutamine synthetase.


Parental fd DNA is efficiently transferred into progeny bacteriophage particles even at low multiplicity of infection.


A metabolic requirement for heat induction of class A lambda lysogens.


Peripheral nerve grafts: experimental studies in the dog and chimpanzee to define homograft limitations.


Isolated unilateral hydrocephalus following ventriculoatrial shunt.


Experimental studies on renal transplantation with special reference to observations on the blood supply by aortography.


A pilot trial of natamycin. A topical antifungal agent.


A study of a recognized antipsychotic agent as a tranquilizer in general practice.


A 17th century country doctor. John Westover of Wedmore.


Roland Parks Mackay 1900-1968.

Roland Parks Mackay 1900-1968.


Nodular sclerotic lymphosarcoma. A further review.


Sequential analysis of constant and prolonged regional chemotherapy for cancer of the lung.


A computer program for the interpretation of blood-gas analysis.


Electrocardiographic interpretation by computer.


Augmented stepwise discriminant analysis applied to two classification problems in the biomedical field.


Effect of inhibition of DNA synthesis on u.v. sensitive Bs strains of Escherichia coli.


An advanced computer for real-time medical applications.


Quantified medical theory and practice at fourteenth-century Montpellier.


Effect of a recA gene on cell division and capsular polysaccharide production in a lon strain of Escherichia coli.


Adolf Meyer and Clifford Beers, 1907-1910.


Berengario on "signa cerebri commoti".

Berengario on "signa cerebri commoti".


Phenotypic suppression by streptomycin-adenlate and bluensomycin-adenylate.


Survival, DNA-breakdown and induction of prophage lambda in a Escherichia coli K 12 recA uvrB double mutant.


Repressor-minus and operator-constitutive de-repressed mutants of F-like R factors: their effect on chromosomal transfer by HfrC.


Interactions between de-repressed F-like R factors and wild type colicin B factors: superinfection immunity and repressor susceptibility.


Identifying recombinational lethals in Drosophila melanogaster.


Immunogenicity of soluble and aggregated common enterobacterial antigen.


Immunity studies in testosterone propionate injected chicks.


Some diagnostic pathologic procedures for the equine practitioner.


Role of certain bacteria in mastitis-metritis-agalactia of sows.


Attempts to dissolve bladder stones by direct injection.


Use of laboratory tests in diagnosis on the farm.


Laboratory diagnosis of infectious bovine abortion.


Reversible versus irreversible renal disease in the dog.


Worldwide status of hydatid disease control.


Mutagenic effects of aflatoxin.

Mutagenic effects of aflatoxin.


The international dimensions of leptospirosis.


Bovine vibriosis and regulatory veterinary medicine.


Confirmation of hog cholera diagnosis by rapid serum-neutralization technique.


Streptomyces sclerogranulatus sp. nov., the producer of sclerothricin.


Localization of sensitivity to kanamycin and streptomycin in 30 S ribosomal proteins of Escherichia coli.


Decrease of melting temperature and single strand scission of DNA by bleomycin in the presence of hydrogen peroxide.


Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase.


Binding of the folate substrate to 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase.


Energy charge and protein synthesis. Control of aminoacyl transfer ribonucleic acid synthetases.


State Board Examinations.

State Board Examinations.


Conformation of DNA isolated from amphibian erythrocytes.


Histological study of the periodontium following replantation of teeth in the dog.


Properties of copper and silver amalgams.


A guide to the appraisal of malocclusion.


Predictability of correlations between in vitro tetracycline potencies and substituent indices.


Induction of root end closure.

Induction of root end closure.


Cofactor inhibition of thymidylate synthetase. Tetrahydrofolic acid analogs.


Frederick Franklin Blicke, 1891-1968.

Frederick Franklin Blicke, 1891-1968.


Elmer Verner McCollum--a biographical sketch (1879-1967).


Effect of certain dietary sugars on hamster caries.


Studies on the improvement of treatment on habu (Trimeresurus flavoviridis) bites. 8. A field trial of the prophylactic inoculation of the habu venom toxoid.


Medicare in Michigan.

Medicare in Michigan.


Further characterization of the two glycosyl glycerides from Streptococcus hemolyticus strain D-58.


Ultrasonics and benzalkonium chloride as a method of sterilizing dental instruments.


Effect of surface conditioners on amalgam marginal leakage.


Editorial. The conflict of responsibility.


Innovations in the care of burned children.


Surgeries for the 1970s: new surgery depends on new technology.


Local anesthesia for patients with hemophilia.


A genetic analysis of a mutant of Escherichia coli with a defect in the assembly of ribosomes.


Two insertions in the galactose operon having different sizes but homologous DNA sequences.


A map of four genes specifying enzymes involved in catabolism of nucleosides and deoxynucleosides in Escherichia coli.


Map location of arginyl-tRNA synthetase mutations in Escherichia coli K-12.


Escape synthesis of beta-galactosidase in strains of Escherichia coli lysogenic for lambda cI-857-h-80-t-68-dlac.


Genetic studies of the ribosomal proteins in Escherichia coli. I. Mutants and strains having 30s ribosomal subunit with altered protein components.


Loss of an episomal fertility factor following the multiplication of coliphage M13.


Complementation experiments between conditional lethal mutants of bacteriophage psiX 174.


Studies with alpha-ketoglutarate dehydrogenase mutants of Escherichia coli.


Genetic control of basal level of alkaline phosphatase in Escherichia coli.


Harvey Cushing: the man and his literary contributions.


The last days of Harvey Cushing.

The last days of Harvey Cushing.


Harvey Cushing: the brain surgeon.

Harvey Cushing: the brain surgeon.


Sarcomas of the brain.

Sarcomas of the brain.


The biology of circadian rhythms from man to micro-organism.


Clinical drug trials. An appraisal of presentations in two medical journals.


Operative treatment of urethral stricture in men.


Vasoconstrictors and general anaesthesia. Ornithine-8-vasopressin and noradrenaline during halothane anaesthesia in a double-blind study.


On the physical principles and methodology of mechanocardiography.


Chromosome multiformity in the genus Ctenomys (Rodentia, Octodontidae). A progress report.


The control of acoustic input in the medial geniculate body and inferior colliculus by auditory cortex.


Enhanced phagocytic function in vivo after whole body irradiation.


The sex ratio in Spina bifida.

The sex ratio in Spina bifida.


The effect of clomiphene and cyclofenil upon pituitary LH and hypothalamic LH-releasing-factor content in the female rat.


Ethylene glycol: A review.

Ethylene glycol: A review.


Does a network structure in spindles of plant cells exist?


Deformation of histologic sections caused by microtomy and subsequent processing: a method of numerical assessment.


Serum concentrations of lipids in rabbits infected with Escherichia coli and Staphylococcus aureus.


Stimulation of humoral and cellular antibody formation in mice by poly Ir:Cr.


The sensitivity of smooth and rough gram-negative bacteria to the immune bactericidal reaction.


Comparison of the protective properties of soterenol and isoproterenol against endotoxin lethality.


Spleen colony formation in radiation chimeras treated with allopurinol and ampicillin.


Occurrence of cells containing globulins in the course of Trichinella spiralis infection in mice.


Immunofluorescent studies on localization of antibody binding sites in Trichinella spiralis.


Trichinella spiralis as the vector of Salmonella typhi murium.


Immune damage to parasitic nematodes.

Immune damage to parasitic nematodes.


Thiabendazole in human trichinellosis.

Thiabendazole in human trichinellosis.


American Academy of Optometry--1970.

American Academy of Optometry--1970.


Regulation of the synthesis of phage-induced proteins in Escherichia coli B.


A review of glaucoma literature.

A review of glaucoma literature.


Studies on the morphogenesis of the middle ear muscles in man.


Properties of antimouse lymphocyte sera produced in various species.


The effect of phytohaemagglutinin on plaque forming cells in the mouse spleen and on skin graft rejection.


Use of subcellular lymphocyte fractions to raise anti- lymphocyte serum.


In vitro assay for antilymphocyte serum.


Effects of heterologous antilymphocyte serum on lymphoid cells labeled with 5-iodo-2-deoxyuridine-125-I.


Introduction to the Alan Gregg memorial lecturer.


Influences of antilymphocyte serum on cell-mediated and antibody-mediated responses.


Production of human antilymphocytic serum in horse with thoracic duct lymphocytes and peripheral blood lymphocytes.


Transfer factor, homograft rejection and the effects of antilymphocyte serum in man.


Use of antilymphocyte serum in the induction of immunological tolerance to tissue allografts.


Development of rapid plasma clearance of antilymphocytic globulin in renal transplant patients.


Selected topics on antilymphocyte serum.


Mode of action of antilymphocyte serum.

Mode of action of antilymphocyte serum.


Specificity in the assembly of multisubunit proteins. The recoveries of activity in the presence of mixtures of several enzymes and a cellular debris were compared with the recoveries of the pure enzymes. In the acid-dissociation experiments, no interference from foreign proteins was observed nor were any cross hybrids between subunits of different enzymes found. This suggests that the intersubunit binding sites are highly specific and have been selected over evolutionary time for correct assembly. In the urea experiments, cross hybridization and decreased yields were observed in a few cases but in most cases the "foreign" unfolded chains did not influence the recovery of the test enzyme. The results suggest that compartmentalization, temporal or spatial, will not be required as far as assembly of subunits of cytoplasmic enzymes is concerned. The results suggest some cross reaction might occur if all peptide chains were unfolding together. If folding occurs during or immediately after translation, this difficulty would be avoided.


Experimental approaches to homogenous antibody populations. Factors controlling the occurrence of antibodies with uniform properties.


Selective translation of T4 template RNA by ribosomes from T4-infected Escherichia coli. The present studies indicate that T4 infection induces an alteration in host ribosomes which restricts the translation of host and other T4-unrelated template RNAs but permits normal translation of T4 RNA. A heat-labile factor has been isolated from T4-infected cell ribosomes which, when combined with normal cell ribosomes, confers upon the latter the property of selective T4 template RNA translation.


A debt of gratitude.

A debt of gratitude.


Rosemary Murphy, M.D.--a tribute.

Rosemary Murphy, M.D.--a tribute.


The treatment of tetanus with special reference to betamethasone.


Bacterial counts in urine. 2. A comparison of different methods.


Bile acid transforming micro-organisms in rats with an intestinal blind segment.


Influences of duodenal acidification on acid and pepsin secretion of the stomach in dogs.


Hyperinfection syndrome with Strongyloides stercoralis.


The response of the rabbit to implants of processed bovine bone (Kiel bone) and the effects of varying the relationship between implant and host bone.


Proline synthesis in Escherichia coli. A proline-inhibitable glutamic acid kinase.


The biosynthesis of folic acid. X. Evidence for an Amadori rearrangement in the enzymatic formation of dihydroneopterin triphosphate from GTP.


The evidence for luteolysin.

The evidence for luteolysin. While it has been possible to demonstrate uterine luteolytic effects in several of the domestic animals, attempts to isolate uterine luteolysin have not been as successful.  The author states this is not surprising for it has been shown that a continuous effect of the endometrium is required even in the living animal.  The total content of luteolytic substances in the endometrium is low, and it would require many extracts to provide enough material to be effective.  The author concludes through experiments on the effect of hypohysectomy in certain domestic animals that the pituitary is not involved in the regression of the corpus luteum and that there are present luteolytic effects induced via the  endometrium.  There is a luteolytic effect in sheep the last day or so of the estrous cycle.  He also suggests through sheep hysterectomy studies that there is such a rapid turnover time of luteolytic substances they are difficult to detect in endometrial extracts.  Unilateral lytic effects have been demonstrated in several species including pig, sheep, cow, and guinea pig according to the author.


Induction of ovulation with gonadotrophins.


Clomiphene.

Clomiphene.


Evaluation of rare adverse effects of systemic contraceptives.


Effectiveness and risks of birth-control methods.


The hypothalamus and control of ovulation.


Postcoital contraception.

Postcoital contraception.


Recent advances in surgical methods of control of fertility and infertility.


Termination of pregnancy.

Termination of pregnancy.


Antispermatogenic agents.

Antispermatogenic agents.


Sites of hormone production in the mammalian testis, and their significance in the control of male fertility.


The defense of medicine in the medieval Muslim world.


George Washington Corner's eightieth birthday.


Suicide among the sick in classical antiquity.


Comparative structural studies of the active site of ATP-guanidine phosphotransferases. The essential cysteine tryptic peptide of arginine kinase from Homarus vulgaris muscle.


The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K 12. A study of the allosteric equilibrium.


The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K 12. Relaxations of the allosteric equilibrium.


Studies on the chemical basis of cellular radiosensitization by 5-bromouracil substitution in DNA. II. Pulse- and steadystate radiolysis of bromouracil-substituted and unsubstituted DNA.


Immunological enhancement.

Immunological enhancement.


The granulomatous inflammatory exudate.

The granulomatous inflammatory exudate.


Inductive tissue interactions in vertebrate morphogenesis.


Inhibition of insulin secretion by diphenylhydantoin in the isolated perfused pancreas.


Emphysema in the nineteenth century.

Emphysema in the nineteenth century.


An improved dip spoon method for use in the screening of urines for significant bacteruria.


Examination of sera for toxoplasmosis antibody using immunofluorescence.


Demonstration of glycogen in glycogenosis types 1, 2 and 4.


A simple technique for the determination of thermal death times of Salmonella.


Some observations on the detection of staphylococcal deoxyribonuclease.


Nongonococcal urethritis associated with human strains of "T" mycoplasmas.


Characteristics of patients with multiple episodes of bacterial endocarditis.


Studies of the circulation with radioactive microspheres.


Abel Ayerza (1861-1918), "black cardiacs".


Transplantation for bilateral renal tumors.


Separation and properties of the mycobactericidal principle from lysosomal components of tuberculous mice.


Some Roman medicine.

Some Roman medicine.


Technique and results of human heart transplantation.


Dr. Richard Bright and Lake Balaton.

Dr. Richard Bright and Lake Balaton.


The lure of Padua.

The lure of Padua.


Reflections on Joseph Lister's Edinburgh experiments on vaso-motor control.


Smollett's defence of Dr. Smellie in "The Critical Review".


Some observations concerning the increase of hospital provision in London between 1850 and 1960.


Richard Bradley's illicit excursion into medical practice in 1714.


The last epidemic of plague in England? Suffolk 1906-1918.


Two contrasting nineteenth-century surgeon dermatologists.


Walker and Nussey--Royal Apothecaries, 1784-1860.


A medical student's career in the early nineteenth century.


Prognostica Galieni.

Prognostica Galieni.


Old hospitals. The Royal Hospital of New Orleans.


Dr. Harold O. Peterson.

Dr. Harold O. Peterson.


Simple renal cysts.

Simple renal cysts.


Vascular changes in the lungs on the plain radiograph of the chest.


Anaesthesia for liver transplantation in the pig.


Immunological aspects of renal allotransplantation.


The planning of patient care in a hospital burn unit.


Renal transplantation in the inbred rat. 13. Modification of rejection by active immunization with bone marrow cells.


Heparin and aspirin in the treatment of hyperacute rejection of renal allografts in presensitized dogs.


Renal transplantation in the inbred rat. XIV. Mechanism of the modified rejection produced by bone marrow cell pretreatment.


Lymphocytophilic antibody titer as a correlative assay for the immunosuppressive activity of antilymphocytic serum.


Fibrin deposition as a pathogenetic mechanism producing glomerulopathy in long surviving renal allografts.


Beagles for studies of histocompatibility and organ transplantation.


Inhibition of skin allograft rejection in trichinella-infected mice.


Transplanted carcinoma in an immunosuppressed patient.


Failure to detect evidence for intravascular coagulation during acute renal allograft rejection.


Prolonged skin allograft survival after treatment of the host with low doses of donor strain histocompatibility antigens.


Prevention of outflow block of the canine liver during transplantation.


Effector mechanisms of skin homograft rejection in agammaglobulinemic chickens.


Recurrent anterior dislocation of the shoulder treated by the Eden-Hybinette operation. Follow-up on 78 cases.


Repair mechanism in irradiated cells.

Repair mechanism in irradiated cells.


Otoneurology.

Otoneurology.


Pharmacology of the central nervous system.


Neuro-ophthalmology: clinical tests of vestibular and oculomotor functions.


Neuroanatomy.

Neuroanatomy.


The autonomic nervous system.

The autonomic nervous system.


Cerebrospinal fluid.

Cerebrospinal fluid.


Surgery of the spinal cord and column.

Surgery of the spinal cord and column.


Pain and motor disorders.

Pain and motor disorders.


Clinical psychiatry.

Clinical psychiatry.


Mental health.

Mental health.


Psychiatry and law.

Psychiatry and law.


Criminal psychopathology.

Criminal psychopathology.


The neuroses.

The neuroses.


Psychiatric nursing and occupational therapy.


A new thymine base analogue, 5-ethyluracil: 5-ethyluridine-5'-pyrophosphate and poly-5-ethyluridylic acid.


Disappearance rate of 133xenon from the liver following partial hepatectomy in dogs.


A pictorial perception paradox.

A pictorial perception paradox.


Cholic acid inhibition of intestinal bacteria.


Some psychoanalytic theories about death: a selective historical review.


Experimental therapeutic trials of leukemia and hematosarcomas: technologic and philosophic aspects.


Small angle x-ray scattering of a homogeneous gamm G-1 immunoglobulin.


Chemical evidence of a disulfide bond in bovine carboxypeptidase A.


Ethoxyformylation of proteins. Reaction of ethoxyformic anhydride with alpha-chymotrypsin, pepsin, and pancreatic ribonuclease at pH 4.


Replication of a bacterial plasmid and an episome in Escherichia coli.


William Dameshek, 1900-1969.

William Dameshek, 1900-1969.


William Dameshek, a personal remembrance.


Sharing Veterans Administration resources.


The pattern of stem cell repopulation in heavily irradiated mice receiving transplants of fetal liver.


The relation betweeen cytogenesis and the formation of different types of synaptic contact.


The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units. This article traces the author's personal history in neuroanatomical studies of the cerebral cortex including his father's pioneering studies using electrophysiology and early neuroanatomical methods. By providing the background context for the observations reported in the original heavily cited Brain Research article, the author describes how his methods of investigation with celloidin embedded material prepared with the Golgi method and Nissl staining revealed for the first time the “barrel fields” of the mouse cerebral cortex that are activated by stimulation of the facial vibrissae (whiskers). The original article reviewed the series of studies published on the murine cortical field in what later was termed a Brain Research Review. Those original observations opened an entire field of cortical organization and function that has remained an active and fertile field of neuroscience investigation.


Retention of corticosterone by cell nuclei from brain regions of adrenalectomized rats.


A new stereotactic instrument for brain operations in laboratory rodents (Muridae).


Reciprocal and serial dendrodendritic synapses in the glomerular layer of the rat olfactory bulb.


The primary structure of porcine pancreatic ribonuclease. 3. The disulfide bonds.


Macrophage aggregation in vitro: a correlate of delayed hypersensitivity.


Isoleucyl transfer ribonucleic acid synthetase is a single polypeptide chain.


Influence of thymosin on cell-mediated and humoral immune responses in normal and in immunologically deficient mice.


Primary rejection of skin allografts in the anterior chamber of the rabbit eye.


An in vitro measure of cellular immunity to fibroma virus.


Immunosuppressive effects of antilymphocyte serum in complement-deficient mice: evidence that immune cytolysis is not essential for ALS activity.


An evaluation of techniques for sampling skin flora.


Immunosuppressive potency of antiserum to thymus glands prepared with ribosomal fraction.


Difficulties with vesicostomies in 15 children with meningomyelocele.


Urinary tract infections in girls: prevalence of spina bifida occulta.


The origin of histamine in the pituitary gland.


Formation of epithelial basement membrane is restricted by scurvy in vitro and is stimulated by vitamin C.


Pulmonary edema in heroin overdose.

Pulmonary edema in heroin overdose.


The repopulation of irradiated bone marrow by the infusion of stored autologous marrow.


John R. Hodgson, A.B., M.D. President, Radiological Society of North America.


Surgical management of massive hemorrhage from the stomach and duodenum.


Recurrent acute polyhydramnios.

Recurrent acute polyhydramnios.


Coxsackie virus B3 calcific pancarditis and hydrops fetalis.


Program elements of federal laws on financing of health facilities.


A selected public health bibliography with annotations.


Radiation therapy: the past, the present, the future. Janeway Lecture, 1969.


Malignant lymphomas: patterns of progression and factors influencing recurrence.


The Janeway Medal and its allegory.

The Janeway Medal and its allegory.


Methods to prevent rejection of homografts in man: a report on living related kidney donor selection by HL-A genotyping.


Stereotactic neurosurgery: the present and future.


An end-expiratory sampler for use during positive-pressure ventilation in man.


Ultrastructural aspects of electrotonic junctions in the spinal cord of the frog.


Identification and terminal distribution of the tubero-hypophyseal monoamine fibre systems in the rat by means of stereotaxic and microspectrofluorimetric techniques.


Projections of the olfactory tract fibers in the nurse shark (Ginglymostoma cirratum).


The use of metronidazole in the treatment of acute ulcerative gingivitis.


Computers for transplantation.

Computers for transplantation.


L-asparaginase in treatment of acute leukaemia and lymphosarcoma. L-Asparaginase was used to treat 40 patients with acute leukaemia or lymphosarcoma. Fifteen with acute lymphoblastic leukaemia either untreated or in relapse after previous therapy were given "Squibb," "Bayer," or "Porton" L-asparaginase. Five of these patients had complete remission of their disease, and four had good partial remission. Eleven patients with acute myeloid leukaemia were treated for a short period with L-asparaginase alone. None of them went into remission though a pronounced fall in the numbers of circulating white cells was seen. Six patients with lymphosarcoma received L-asparaginase, two of them having good partial remissions.The toxic side-effects of the L-asparaginase from the three sources seemed to vary, and L-asparaginase from Erwinia carotovora appeared to be antigenically different from the enzyme produced by Escherichia coli.The way in which leukaemic cells become resistant to the action of the enzyme requires further investigation. To overcome this resistance asparaginase should be used in combination with other drugs in the treatment of acute leukaemia.


Thermographic localization of incompetent perforating veins in the leg. Incompetent perforating veins in the leg were localized separately by clinical and thermographic methods. Clinically, the methods used were a multiple tourniquet test and palpation for fascial defects. Thermographically, the diagnosis of an incompetent perforator was made by finding rapid and localized heat flow to the skin in a cooled limb with occlusion of circulation in the superficial veins distally and proximally. Exploration of all the sites marked clinically or thermographically showed that the clinical method detected 60%, missed 40%, and gave false-positive results in 40%, while thermography detected 94.5%, missed 5.5%, and contributed 13% false-positive results. All these findings show a highly significant difference (P<0.0005) in favour of the thermographic technique as against the clinical method.


Transient asymptomatic bacteriuria in infancy. Spontaneous clearing of bacteriuria occurred in three infants during the neonatal and early infancy period. In all cases, the presence of bacteria was confirmed by bladder puncture, no signs of clinical infection were present, and no treatment was given. The same host defence mechanisms as exist in adults were probably responsible for this phenomenon.


Double-blind controlled clinical trial of clofazimine in reactive phases of lepromatous leprosy. A double-blind controlled trial in 24 lepromatous leprosy patients in reaction showed that clofazimine (Lamprene) controlled symptoms of erythema nodosum leprosum reaction in lepromatous leprosy better than prednisolone. Clofazimine also appeared to be significantly superior in preventing recurrence once the reaction had been controlled. There was a statistically significant rise in serum albumin among inpatients on clofazimine as compared with patients on prednisolone, but no difference in terms of neurological status, bacterial index, morphological index, and renal functions. Red/black hyperpigmentation was seen among practically all patients on clofazimine. No other side-effects or deleterious systemic effects were observed.


Recent advances in jaundice. Medical aspects of investigation and treatment.


Influenza and respiratory failure.

Influenza and respiratory failure.


Respiratory failure in chest wall injuries.


Serial hemodynamics after renal allotransplantation in man.


Non-obstetric surgery during pregnancy.

Non-obstetric surgery during pregnancy.


Repair after excision of large superficial cancers.


Clinical evaluation of a new tricyclic antidepressant iprindole.


Circadian rhythms.

Circadian rhythms.


Morphological characteristics of the sporogonous cycle of Plasmodium cynomolgi in Anopheles stephensi.


Effect of sulfation on the gastrointestinal actions of caerulein.


More on models for the secretion of pepsin and other proteins.


A method for selecting streptomycin-sensitive mutants of R factors which adenylate streptomycin.


Double-blind clinical evaluation of the efficacy and safety of ergostine-caffeine, ergotamine-caffeine, and placebo in migraine headache.


The use of lithium for manic-depressive psychoses.


Hypersensitivity reactions in guinea pigs to group A hemolytic streptococci.


Homologous skin-sensitizing activity of rabbit anti-hydrocortisone hemisuccinate antibodies. II. Inhibition and adsorption studies on "early-antibody"-induced P-K type reaction.


The earliest dental literature.

The earliest dental literature.


Accepted Dental Therapeutics 1969-1970. A historical review.


Enteric colibacillosis in the newborn pig: problems of diagnosis and control.


Ecology of Venezuelan equine encephalitis virus in Panama.


Methods of assessing the psychrotrophic bacterial content of milk.


Sterilization by radiofrequency induction heating: a method for the in situ sterilization of vessels in automatic bacteriological apparatus.


A new multiple inoculator for bacteriocine typing.


Salmonellae in meat and poultry, poultry plant cooling waters and effluents, and animal feedingstuffs.


On the growth and survival of Clostridium septicum in soil.


Nomenclature of the proteins of cow's milk: third revision.


Emergence of stereotaxic surgery.

Emergence of stereotaxic surgery.


Fixation of insect hemocytes for electron microscopy: a comment.


The persistence of a microbial flora during postembryogenesis of Drosophila melanogaster.


Who first reported an infectious disease in a "wild" insect, or other invertebrate, in the United States?


Edward A. Steinhaus.

Edward A. Steinhaus.


Biosynthesis of 50 s ribosomal subunit in Escherichia coli.


The United States Pharmacopeia.

The United States Pharmacopeia.


Detection of circulating heart-reactive antibody in human heart transplants.


Caesar Peter Moeller Boeck (1845-1917). Boeck's sarcoidosis.


Biblical quail incident.

Biblical quail incident.


Bibliography of the Japanese literature.


Genetic studies of the ribosomal proteins in Escherichia. coli. II. Altered 30s ribosomal protein component specific to spectinomycin resistant mutants.


Studies on the functions of the RNA polymerase components by means of mutations.


Long-term evaluation of decontamination of inhalation-therapy equipment and the occurrence of necrotizing pneumonia.


Michael M. Davis.

Michael M. Davis.


Lymphosarcomas in children.

Lymphosarcomas in children.


Fatal septicemia due to nonpigmented Serratia marcescens.


Three marrano-jewish medical botanists of sixteenth century.


NSNA (National Students Nurses' Association)--past, present, and future.


Max Schur, 1897-1969.

Max Schur, 1897-1969.


The train ride: a study of one of Freud's figures of speech.


Freud's déjà vu on the Acropolis. A symbolic relic of 'mater nuda'.


IPPB in surgical patients. Use and abuse.


The impact of clinical trials of drugs on the investigator, the industry and the country.


Prognostic significance of clinical, angiographic and histological findings in renal carcinoma. A study of 31 cases.


Blood flow and diffusion through mammalian organs.


Mechanism of conjugation and recombination in bacteria. V. Effect of edeine on F+ cells.


Studies on mycobacterial sensitizing fractions. 3. PPD and PPD-S protein preparations isolated from four BCG substrains.


On the mechanism of variation in Escherichia coli mutabile.


In memoriam Professor J.W. Duyff.

In memoriam Professor J.W. Duyff.


Catecholamine metabolism in essential hypertension.


Cardiac effects of alcohol.

Cardiac effects of alcohol.


Diffuse glomerulonephritis associated with infected ventriculoatrial shunt.


Cytological studies on normal and surviving mast cells in vitro.


The morphologic development of the sinoatrial node in the mouse.


Comparative ultrastructure of cardiac cell membrane specializations. A review.


Boerhaave on inflammation. I.

Boerhaave on inflammation. I.


Kidney donors--the myth of informed consent.


Effect of prenatal drugs on the behavior of the neonate.


Nicotinic acid side effects and toxicity: a review.


A double-blind comparison of lithium and chlorpromazine in the treatment of manic states.


Wladimir G. Eliasberg 1887-1969.

Wladimir G. Eliasberg 1887-1969.


Freud on war.

Freud on war.


Anaesthesia and the British public, 1846-56. Extracts from the undergraduate prize essay (1969).


Renal transplantation and the anaesthetist.


Anaesthetic literature.

Anaesthetic literature.


H.P. Crampton, MA, MD, FFARCS, DA.

H.P. Crampton, MA, MD, FFARCS, DA.


Anaesthesia for the surgeon-anaesthetist in difficult situations: the use of intramuscular 2(O-chlorophenyl)-2 methylamino cyclohexanone HCl (Parke Davis CI-581, Ketamine).


Ralph M. Waters Memorial Lecture.

Ralph M. Waters Memorial Lecture.


Cardiac pacemakers as an anaesthetic problem.


Repair pattern in the reticular lamina of the organ of Corti after hair cell loss.


A simple procedure for fractionation of transfer RNA.


The efferent olivo-cochlear bundle in the guinea pig cochlea.


Selection of media for the isolation of common bacterial L-phase organisms from a clinical specimen. The L-phase of 13 bacteria commonly associated with disease were induced by penicillin and inoculated into various solid and broth media; their growth was recorded for a period of 14 days. Plates containing highly purified agar and sucrose as the stabilizing agent and those incubated under aerobic conditions gave the best results. Magnesium seems to be necessary for growth in broth media on primary isolation, although it may not be necessary on multiple transfers after a more stable state has been reached. Growth in broth media is much more difficult to achieve. Reversion is aided by using a higher concentration of agar in plates, by decreasing the sucrose concentration, and by omitting the antibiotics and horse serum. A procedure has been outlined for the routine culture and identification of L-phase organisms from a clinical specimen.


Site of action of nitrofurantoin in experimental urinary tract infection. The effectiveness of nitrofurantoin in suppressing bacterial growth in the urinary tract was evaluated by using two different experimental models. Pyelonephritis was produced in rats by direct inoculation of 10(4)Escherichia coli in the medulla of left kidney. Ascending urinary tract infection was induced by inoculation into the urinary bladder of 10(7)Proteus mirabilis, after a partial cystectomy. Nitrofurantoin was shown to be effective in suppressing bladder bacteriuria, in preventing ascending pyelonephritis, and also in preventing bacterial multiplication in kidney tissue following direct inoculation.


Production of tumor-inhibitory L-asparaginase by submerged growth of Serratia marcescens. Production of a tumor-inhibitory asparaginase by submerged fermentation with Serratia marcescens ATCC 60 was studied to ascertain optimal nutritional conditions for large-scale production leading to enzyme purification studies. Five strains of S. marcescens were screened in shake-flask studies and were found to produce 0.8 to 3.7 IU/ml 48 hr after inoculation. The requirements for asparaginase production with S. marcescens ATCC 60, the high producing strain, included the following: 4% autolyzed yeast extract medium (initial pH 5.0), an incubation temperature of 26 C, and limited aeration for a zero level of dissolved oxygen during the fermentation. Addition of various carbohydrates to the fermentation medium did not enhance yields. The peak cell population in the fermentation medium and the maximal asparaginase yields occurred simultaneously. Highest enzyme yields were found when the pH of the fermentation cycle rose to approximately 8.5. Yields of 4 IU of asparaginase/ml of cell suspension have been obtained consistently in 40 to 42 hr from 10-liter volumes (500 ml/4-liter bottle) produced on a reciprocating shaker. Scale-up to a 60-liter fermentor yielded 3.1 IU/ml in 35 hr.


Characterization of ornithine decarboxylase-positive, nonmotile strains of the Klebsiella-Enterobacter group. Thirty-seven strains of ornithine decarboxylase-positive, nonmotile Klebsiella-Enterobacter organisms isolated from 36 patients were studied by biochemical and serological testing. Five strains gave biochemical reactions which conformed closely to those of Escherichia coli; three strains gave positive Quellung reactions to specific Klebsiella antisera. (Two of these were thought to be Enterobacter in spite of this typing reaction.) The remaining 29 strains were classified as Enterobacter. These results demonstrate the necessity of doing both an ornithine decarboxylase test and a motility test to differentiate Klebsiella from Enterobacter. Had only a motility test been done, they all would have been called Klebsiella.


Antigenicity of influenza vaccine from bovine cell cultures. An experimental vaccine prepared from influenza virus strains propagated in bovine kidney cell cultures, purified by zonal centrifugation, and further treated with ether was studied in man for the incidence of clinical reactions and hemagglutination-inhibition antibody levels induced. The results were equivalent to those obtained in a simultaneous study made with a commercially licensed influenza vaccine derived from viruses propagated in the embryonated egg and also purified by zonal centrifugation, but not treated with ether. Comparison of the macromethod and the micromethod for determination of hemagglutination-inhibition antibody titers revealed that lower initial titers and lesser increments in antibody levels following vaccination were obtained by the microtechnique.


Simple method for rapid determination of antibiotic blood levels. A simple method for the rapid determination of antibiotic blood levels is described. Results are readily obtainable within 4 to 6 hr. The reported procedure is based upon determination of the highest dilution of a patient's serum capable of inhibiting dextrose fermentation by a standardized inoculum of a staphylococcus strain or of an Escherichia coli strain, when colymycin or polymyxin are involved, as compared to previously determined endpoints in this regard of defined concentrations of the different antibiotics dissolved in normal human serum. Excellent correlation was observed with 36 serum specimens that contained different antimicrobial agents in varied concentrations when simultaneously assayed by the standard method and the subject procedure of this report.


Radiation sterilization of prototype military foods. 3. Pork loin. Ten lots of pork loin, packed in cans, were inoculated with approximately 10(6)Clostridium botulinum spores per can. Each lot was seeded with a different strain; five type A and five type B strains were used. The pack comprised 5,690 cans, including controls, and contained about 10(9) spores per dose. The cans were irradiated with Co(60) in the range of 0 to 5.0 Mrad (0.5 Mrad increments) at 5 to 25 C, incubated for 6 months at 30 C, and examined for swelling, toxicity, and recoverable C. botulinum. The minimal experimental sterilizing dose (ESD) based on nonswollen, nontoxic, but nonsterile end points was 2.5 < ESD </= 3.0 Mrad, and based on non-spoiled sterile cans was 3.5 < ESD </= 4.0 Mrad. The theoretical minimal radiation dose (MRD), the 12D equivalent, varied with the method of computation: 4.74, 4.33 +/- 0.17, and 4.19 to 4.99 Mrad were obtained by the Weibull, Spearman-Karber, and Schmidt-Nank techniques, respectively. Calculation of D and MRD values by the conventional Schmidt-Nank method produced increasing values with rising dosage; this finding was compared with the data derived by the other two methods of calculation. Suggestions for estimating the MRD of a prototype radiation process are offered.


Application of paraffin bait technique to the isolation of Nocardia asteroides from clinical specimens. The principal findings of a study for further evaluating paraffin baiting as a routine laboratory diagnostic procedure in the isolation of Nocardia asteroides, the etiological agent of nocardiosis, are reported.


Variants of Serratia marcescens induced by freeze-drying. Unusually high numbers of pigmentless variants and sectored colonies in cultures of lyophylized Serratia marcescens are reported. Clonal analyses of sectored colonies show the presence of unstable bacteria that continue to sector again when plated. Further analysis of pigmentless variants suggest that pigment formation, oxygen uptake, and the production of an inducible protease are affected.


Isolation of Salmonellae and Shigellae from an artificial mixture of fecal bacteria. Numerous selective media, available commercially, act by suppressing "normal" bacterial inhabitants of the intestine while permitting the growth of so-called pathogenic representatives of the family Enterobacteriaceae. This investigation attempts to evaluate the action of Salmonella-Shigella (SS) agar, xylose lysine desoxycholate (XLD) agar, and hektoen enteric (HE) agar. Salmonellae and shigellae, isolated from clinical material, were mixed in various ratios with escherichiae, Klebsiella-Enterobacter-Serratia group bacteria, and members of the tribe Proteeae, also of clinical origin. Several of the mixtures were plated in multiple dilutions on the three media. Stools in preservative were also used for evaluation of the media after the addition of definite numbers of the pathogenic bacteria. Results indicate that SS agar suppresses the shigellae along with the autochthonous members of Enterobacteriaceae. XLD and HE agars readily permit the recovery of shigellae as well as salmonellae. This recovery is not obscured by the higher yield of other species obtained with these media.


Rapid plate test for evaluating phage induction capacity. An agar plate test is presented as a screening test for phage induction capacity of various chemicals.


Schizophrenia and interference. An analogy with a malfunctioning computer.


Localization of Powassan virus in Dermacentor andersoni ticks by immunofluorescence.


Radiation survival of bacterial spores in neutral and alkaline ice.


Ventriculo-cardiac shunts in the first week of life. Results of a controlled trial in the treatment of hydrocephalus in infants born with spina bifida cystica or cranium bifidum.


The recurrence risk in spina bifida cystica and anencephaly.


The intrinsic innervation of the dilated ureter in children with myelomeningocele.


Pre-operative protection of myeloceles with cast vinyl film.


The evaluation of functional disorders of the urinary tract in children with spina bifida.


Experience in the use of ventriculoatrial shunts with the Pudenz valve.


Lipomas of the cauda equina and other fatty tumours related to neurospinal dysraphism.


Short-term verbal memory in hydrocephalic children.


Diagnosis of Cleland-Arnold-Chiari deformity on plain radiographs of the spine.


Neuron population in the lumbosacral cord of myelomeningocele children.


Further follow-up study of early operation for open myelomeningocele.


An appraisal of the management of spina bifida cystica.


Urinary diversion in children using intestinal conduits.


Jugular foramen in congenital hydrocephalus.


Interactions in the recovery of Salmonella typhimurium damaged by heat or gamma radiation.


A study of Chromobacterium typhiflavum from the rat.


A rapid method for lyophilizing Streptomyces cultures.


An automatic inoculation device for seeding bacterial cultures.


Effect of irradiation temperature on inactivation of Clostridium botulinum toxin type E by gamma rays.


Lack of pooling in portal vein in endotoxin shock in the dog.


Extravascular lung water and distribution of pulmonary blood flow in the dog.


Computer computations of cardiac output using the gamma function.


A source of error in measuring flow with indocyanine green.


Complex between beta-lactoglobulin and kappa-casein. A review.


Mutant tyrosine transfer ribonucleic acids.


A purified group A streptococcal pyrogenic exotoxin. Physiochemical and biological properties including the enhancement of susceptibility to endotoxin lethal shock. Purified pyrogenic exotoxin from Group A streptococcal filtrates (Streptococcus pyogenes, type 10, strain NY-5) has been characterized primarily as a protein complexed with hyaluronic acid. Amino acid composition and analysis revealed a typical acidic protein with an average molecular weight of 29,000. The purified exotoxin was free of streptolysins O and S, nicotinamide adenine dinucleotidases (NADases), deoxyribonucleases (DNases), mucopeptide, and endotoxins. The biological activity was destroyed when the exotoxin was heated at 65 degrees C for 30 min or boiled for 2 min. The biological activities investigated were pyrogenicity in rabbits (minimal pyrogenic dose-3 hr, 0.07 microg/kg), lethality in rabbits (LD(50), 3500 microg/kg), skin test dose in human skin (> 10(9) skin test doses, per mg toxin), cytotoxicity of rabbit spleen macrophage (Cytotoxic Index 0.5-10 microg/ml), enhancement of susceptibility to endotoxin shock (in rabbits > 100,000-fold), and antigenic analysis (A-type toxin). The exotoxin was immunogenic and it was possible, therefore, to immunize animals against the various toxic activities. The immunity was specific for the A-type toxin. The clinical implications of the highly significant enhancement effect of these exotoxins are discussed. It is suggested that clinical or subclinical infection with Group A streptococci could prepare the host for fatal shock from Gram-negative infections or the inadvertent injection of small amounts of Gram-negative bacterial endotoxins.


Duplicate genes for tyrosine transfer RNA in Escherichia coli.


A method for preparing single mammalian ova for cytological studies using light and electron microscopy.


Poly 5-ethyluridylic acid, a polyuridylic acid analogue.


Changes in the ultrastructure of chinchilla spermatozoa in different diluents.


Immunological aspermatogenesis in man. II. Response to corticosteroids in cases of non-obstructive azoospermia with a positive blastoid transformation test.


Separation of isoenzymes by zonal centrifugation.


Transplantation antigens in the central nervous system.


Inhibition of 3H-thymidine incorporation into rat liver nuclei by E. coli L-asparaginase.


Effects of optic nerve section on the double-flash ERG in unanaesthetised rabbits. A study of centrifugal influences on the ERG.


Autogenous bone marrow transplants in the rat.


Cellular growth, nutrition and development.


Official roster of affiliate societies.

Official roster of affiliate societies.


Cause of renal injury in kidneys obtained from cadaver donors.


Transabdominal ligation-resection of the esophagus in cases of bleeding esophageal varices.


Estrogen and survival data in carcinoma of the prostate.


The progressive nature of pulmonary contusion.


Lymphatic absorption of intraperitoneal endotoxin in the dog.


Transplantation of in situ perfused kidneys.


Pancreatitis in renal transplantation.

Pancreatitis in renal transplantation.


Recovery of immune responsiveness after cessation of thoracic duct drainage in calves and man.


Ribosome degradation and the degradation products in starved Escherichia coli. I. Comparison of the degradation rate and of the nucleotide pool between Escherichia coli B and Q-13 strains in phosphate deficiency.


Ribosome degradation and the degradation products in starved Escherichia coli. II. Changes in base sequence of ribosomal RNA during degradation induced by phosphate and magnesium starvation.


Ribosome degradation and the degradation products in starved Escherichia coli. 3. Ribosomal RNA degradation during the complete deprivation of nutrients.


A simple method for isolating RNA from bacteria.


RC gene control in Escherichia coli is not restricted to RNA synthesis.


Further investigations of the multiple fractions of leucyl transfer ribonucleic acid synthetase activity from Escherichia coli.


Ludwig Heilmeyer in memoriam.

Ludwig Heilmeyer in memoriam.


Characterization of 5.8-S RNA from a complex with 26-S ribosomal RNA from Arbacia punctulata.


Indomethacin in extra-articular lesions.


A double-blind trial of metoclopramide and prochlorperazine in general practice.


A comparison of codeine compound and "saridone" in the pain of rheumatoid arthritis.


Beclomethasone dipropionate compared with betamethasone-17-valerate in the treatment of inflammatory dermatoses.


Osteoplasty in complete clefts of the secondary palate.


POR 8, a new vasoconstrictor substitute for adrenaline in plastic surgery.


Primary treatment of naso-ethmoid injuries with increased intercanthal distance.


Two cases of purpura fulminans.

Two cases of purpura fulminans.


Antibody levels detected by the fluorescent antibody technique in mice infected with Plasmodium vinckei and P. chabaudi. The malaria parasites of mice are convenient models for immunological studies. Plasmodium vinckei and P. chabaudi are similar parasites which behave differently in mice, the former invariably being fatal whereas the latter seldom kills the host. The experiments described in this paper were performed in order to compare the antibody levels in the Ig, IgM and IgG serum fractions in mice cured of P. vinckei infections and naturally recovered from P. chabaudi. The technique involved using specific labelled antimouse-Ig, -IgM and -IgG sera and had not previously been applied to malaria infections. The results showed that the patterns of antibody production were similar in cured and naturally recovered mice. IgG antibodies were involved from an early stage of the infection and IgM antibodies persisted throughout the period of experiment and even after challenge. These results are significant in that they indicate a pattern of immune response different from the classically accepted one and draw attention to the fact that even in highly immune animals considerable amounts of IgM may be present.


Malaria parasitaemia and body temperature in a semi-immune population in southern Nigeria.


L-asparaginase activity in plasma and other biological fluids.


Clinical evaluation of L-asparaginase. Introduction.


Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors.


Toxicity of E. coli L-asparaginase in man.


Non-steroidal antifertility agents affecting brain mechanisms. Many non-steroidal agents prevent ovulation by acting on the nervous structures that control the secretion of gonadotrophins. Information on the neuroendocrine factors involved in the process of ovulation in mammals is presented in this paper and is then used as the background for explaining the mode of action of drugs which inhibit ovulation through an effect on the central nervous system. Such drugs are found among the following classes of compounds: CNS depressants, tranquillizers, cholinergic blocking agents, and adrenergic blocking agents. Although it is unlikely that any of the specific agents discussed in this paper will have clinical application, because of associated behavioural effects, the knowledge gained by studying the mode of action of these compounds indicates pathways to follow in the search for new anti-ovulatory drugs.


E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children.


James Ewing society, 1940-1969. Presidential address.


Cardiovascular effects of psychotropic drugs.


An "internal" feedback mechanism controlling follicle stimulating hormone releasing factor.


Failure of putrescine and other polyamines to promote FSH release in vitro.


Macrophage receptors for IgG aggregates.


Nuclear and cytoplasmic protein accumulation in pha-stimulated human lymphocytes during blastogenesis.


Membrane structure as seen with a double replica method for freeze fracturing.


Immunofluorescent localization of the gastrin-secreting G cells in the pyloric antrum of the pig.


Occupational mental health: review of an emerging art.


Women in industry: a psychiatric view.

Women in industry: a psychiatric view.


Occupational psychiatry. Historical and philosophical reflections.


Research in occupational psychiatry.

Research in occupational psychiatry.


Patterns of haematopoietic activity in various micro-environments.


A comparative study of the distribution of amines in the perivascular zone of the median eminence of the echidna, rabbit and rat.


Renal homotransplantation in children.

Renal homotransplantation in children.


Assessment of fetal health by analysis of maternal steroids.


The effect of an antimicrobial mouth rinse on dental plaque, calculus and gingivitis.


The implantation of decalcified human dentin and cementum with autogenous bone and marrow into the subcutaneous tissues of the rat.


Final impressions for complete dentures.


A sclerosing procedure for hypermobile edentulous ridges.


Swallowing and resting forces related to lingual flange thickness in removable partial dentures.


The bolt inlay: a new method of repairing and modifying cemented fixed prostheses.


Precision removable partial dentures with pontic abutments.


An intraoral parallelometer.

An intraoral parallelometer.


Cadmium bands in construction of full cast crowns.


Prefabricated maxillary endosteal implant prostheses.


Removable dies for crowns, inlays, and fixed partial dentures.


Effect of inhibitors of DNA synthesis of UV-sensitive derivatives of Escherichia coli strain K-12.


Spontaneous deletion formation in several classes of Escherichia coli mutants deficient in recombination ability.


The oral manifestations of diabetes mellitus. A review.


An historical review of full coverage of the natural dentition.


Attention and perception in schizophrenia.


Attention and schizophrenia.

Attention and schizophrenia.


Significance and limitations of electromagnetic blood flowmetry. Experimental and clinical results.


The interplay of factors determining a cancer pattern.


A survey of metal carcinogenesis.

A survey of metal carcinogenesis.


Vagotomy and drainage procedures. The present position.


Intra-operative blood flow measurements with the xenon washout technique.


Diagnostic dental x rays and the patient--an overview. Bureau of radiological health.


Transformation of labeled cholesterol, 20-alpha-hydroxycholesterol, (22R)-22-hydroxycholesterol, and (22R)-20-alpha, 22-dihydroxycholesterol by adrenal acetone-dried preparations from guinea pigs, cattle and man.


Thiabendazole: toxicological, pharmacological and antifungal properties.


Thiabendazole in the treatment and control of parasitic infections in man.


Growth characteristics of type E Clostridium botulinum in the temperature range 34 to 50 degrees F. TID-24779.


A study of the effect of ionizing radiation on resistance, germination, and toxin synthesis of Clostridium botulinum spores, types A, B, and E. TID-25178.


A study of the effect of ionizing radiation on resistance, germination, and toxin synthesis of Clostridium botulinum spores, types A, B, and E. TID-25179.


Growth characteristics of type E Clostridium botulinum in the temperature range of 34 to 50 degrees F. TID-24781.


Growth and toxin production of Clostridium botulinum types E, nonproteolytic B, and F in nonirradiated and irradiated fisheries products in the temperature range of 38 degrees to 50 degrees F. TID-24882.


Physiological studies on Clostridium botulinum, type F. ORO-3347-7.


Physiological studies on Clostridium botulinum, type F. TID-24780.


Growth and toxin production of Clostridium botulinum types E, nonproteolytic B, and F in nonirradiated and irradiated fisheries products in the temperature range of 36 degrees to 72 degrees F. TID-24881.


Simultaneous measurement of blood parameters using radiochromium-labeled red cells and radioiron-labeled plasma. SAM-TR-68-113.


Sensitivity of serologically classified strains of escherichia coli of human origin to the serum bactericidal system.


Some approaches to the therapeutic exploitation of metabolic sites of vulnerability of neoplastic cells.


Increased transfer RNA methylase activity in a liver tumor from chicks with Marek's disease.


Endocrinologic factors in the design of more selective antitumor agents.


Reduction of toxicity in cancer chemotherapy.


Nutritional factors in the design of more selective antitumor agents.


The need for additional alkylating agents and antimetabolites.


Propagation of cancer: targets for future chemotherapy.


Francis F. Foldes, M. D.

Francis F. Foldes, M. D.


Disposable fiberglass filter to counter bacterial contamination of intermittent positive pressure breathing equipment.


Drug treatment in depressive illness.

Drug treatment in depressive illness.


Bacteriolytic spectrum of the enzyme produced by Acanthamoeba castellanii.


Runaway demand pacemaker: report, in vitro reproduction, and review.


Evarts A. Graham.

Evarts A. Graham.


The Society of Thoracic Surgeons. Membership roster.


Clinical evaluation of a new antianxiety agent Ba-30803.


Benzoctamine treatment of hospitalized cultural-familial retardates.


Studies on the European eel (Anguilla anguilla, L).


The eradication of cross-infection from anesthetic equipment.


Endocrine influences on spermatogenesis in cold-blooded vertebrates.


Antiasthmatic action of corticosteroids: a review of the literature on their mechanism of action.


Tissue respiration in various sites of the hypophyseal portal system in some mammals.


Studies on the behavior of skin autografts following their in vitro treatment with cancer cells.


The limitation of rate of photoperiodically induced testicular growth in the white-crowned sparrow Zonotrichia leucophyrys gambelii: the effect of hemicastration.


Adrenergic and cholinergic systems in the hypothalamus of the Japanese quail (Coturnix coturnix japonica).


Timing of oviposition in white Leghorn hens under constant uniform light.


Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. II. The effect of thyroxine following treatment with propylthiouracil.


Rhythmometry on urinary 17-ketosteroid excretion by healthy men and women and patients with chronic schizophrenia; possible chronopathology in depressive illness.


The fate of vasotocin and oxytocin in the domestic fowl.


Evolution of gonocytes in the rat testis during late embryonic and early post-natal life.


Gonadotropic function of the autotransplanted pituitary gland in the female toad Bufo bufo (L.).


In viso veritas.

In viso veritas.


A comparative approach to fish respiration.


Crystallization and properties of L-asparaginase from Escherichia coli.


The monamycins, a new family of cyclodepsipeptide antibiotics.


Inhibitory action of cholecystokinin-pancreozymin on gastric pepsin secretion.


Development of faecal immunoglobulins and coproantibodies in infants after artificial oral colonization with E. coli 083.


Detection of complement-producing cells with macrophage antiserum.


Fine structure of chromatic granules in Trichomonas vaginalis Donné.


A possible definition of the cancer problem.


Proposal for classifying strain PG-24 and related canine mycoplasmas as Mycoplasma edwardii sp. n. Mycoplasmas recovered recently from dogs were found unrelated to three classified canine Mycoplasma serotypes but were similar in biological and serological properties to a Mycoplasma strain (C21, PG-24) isolated 18 years earlier. It is proposed that strains with the characteristics described be designated Mycoplasma edwardii sp. n.


Characterization of injury incurred by Escherichia coli upon freeze-drying. When cells of Escherichia coli ML30 were suspended in 2% gelatin and frozen at -40 C, no appreciable metabolic damage or death occurred. After freeze-drying for 8 hr at a platen temperature of 49 C and rehydration with a mineral salts medium, survival of the cells was 0.6%. Metabolic damage of the survivors was found to be 23%. Permeability alterations were detected by several criteria. Freeze-dried cells were susceptible to antibiotics normally ineffective against E. coli and leakage of ribonucleic acid (RNA) occurred. Analysis of ribosomal extracts of rehydrated freeze-dried cells demonstrated the presence of appreciable degradation products. Permeability alterations were shown to be reversible by the observation that antibiotic susceptibility was a time-dependent process and that the gratuitous inducer of beta-galactosidase was not concentrated by freeze-dried cells until the injured cells had been incubated in a nutrient medium for 300 min or more. At approximately the same time, metabolic damage was repaired. RNA synthesis preceded protein synthesis by about 150 min, and deoxyribonucleic acid synthesis occurred with the resumption of normal growth. This was interpreted to be the result of repair of RNA taking place before protein synthesis and growth could resume. A pronounced increase in the lag time of freeze-dried cells was also observed. Peptides and Casamino Acids shortened the lag time for freeze-dried cells but not for the controls. Glycerol and glucose were found to be better carbon sources for growth of freeze-dried cells than sodium lactate or sodium succinate.


Compartmentation in the induction of the hexose-6-phosphate transport system of Escherichia coli. The induction of the hexose-6-phosphate transport system was investigated. Glucose-6-phosphate (G6P) at concentrations as low as 10(-4)m was able to induce this system in wild-type cells, as well as in mutants lacking phosphoglucose isomerase or G6P dehydrogenase. Growth in the presence of fructose-6-phosphate (F6P) induced the system only if the cells contained phosphoglucose isomerase. Furthermore, glucose and F6P were found to induce the system only if the extracellular concentration of G6P became appreciable in the medium as a consequence of the leakage of intracellular G6P formed from the glucose or F6P. Intracellular G6P was not an inducer even at high concentrations. The metabolism of glucose inhibited the induction of the hexose-6-phosphate transport system. Hypotheses for this compartmentalization of inducer and membrane-associated induction are presented.


Amino sugar sensitivity in Escherichia coli mutants unable to grow on N-acetylglucosamine. Studies were conducted on two mutants of Escherichia coli that lack either glucosamine-6-phosphate deaminase or N-acetylglucosamine-6-phosphate deacetylase and which accumulate glucosamine-6-phosphate or N-acetylglucosamine-6-phosphate, respectively, when grown in the presence of N-acetylglucosamine. The addition of 10(-4) to 10(-5)mN-acetylglucosamine to these mutant strains caused a rapid and complete inhibition of growth on substrates that enter the catabolic pathways at or below the level of fructose-6-phosphate. Growth on glucose was inhibited to a lesser degree, whereas only minor inhibition occurred when the pentoses were used as substrates. Growth on gluconate was found to be totally unaffected by these levels of N-acetylglucosamine. The objective of this investigation was to determine the nature of this "amino sugar sensitivity" phenomenon and the conditions under which it could be overcome. It was found that this amino sugar sensitivity was abolished when an exogenous source of pentose such as uridine was included in the culture medium. Experiments are described indicating that the accumulated amino sugar phosphate metabolites interfere with an early step in hexose metabolism of both mutants, resulting in a pentose deficiency and consequent inhibition of growth on certain substrates.


Interaction of ribosomes and the cell envelope of Escherichia coli mediated by lysozyme. Evidence is presented suggesting the existence of a natural ribosome-membrane complex. A reconstruction system is described wherein free ribosomes form a complex which appears to involve cell fragments. The reconstructed complex is similar in stability to the inferred natural complex. The reconstructed complex is generated by lysozyme, and it is concluded that at least part of the inferred natural complex is also generated by lysozyme. These results are discussed with reference to existing data concerning certain membrane-associated systems in bacteria.


Regulation of ribosomal protein synthesis in Escherichia coli. The kinetics of synthesis of ribosomal, nonribosomal, and total protein, and of ribosomal ribonucleic acid (RNA), were measured in Escherichia coli during a shift-up involving a doubling of specific growth rate. The increase in ribosomal protein synthesis was not accompanied by a corresponding decrease in non-ribosomal protein synthesis. Thus, the average rate of protein synthesis per ribosome increased after the shift. The increase did not occur by an increase in polypeptide chain growth rates. The average growth periods of ribosomal and nonribosomal proteins did not change after a shift, and were constant in cells in balanced growth over a wide range of specific growth rates. The average growth period for ribosomal protein was twice that for nonribosomal protein. The fraction of ribosomes in polyribosomes was found to increase after the shift, accounting for the increase in ribosomal protein synthesis and in protein synthesis per ribosome. These results show that ribosomal protein synthesis is regulated by control of initiation of either transcription or translation of ribosomal protein messenger RNA, by some means other than availability of free ribosomes. If the messenger for ribosomal protein is ribosomal RNA, the conclusions can be extended to apply to regulation of ribosomal RNA synthesis. In support of this, it is shown that ribosomal RNA and ribosomal protein synthesis are closely coordinated during a shift.