Studies on the immunology of human malaria. II. Characterization of antibodies to Plasmodium falciparum infections.


Occlusion and operative dentistry.

Occlusion and operative dentistry.


Occlusion and prosthetic dentistry.

Occlusion and prosthetic dentistry.


Studies on the immunology of human malaria. I. Preliminary characterization of antigens in Plasmodium falciparum infections.


Double-blind crossover comparison of bc-105, methysergide and placebo in the prophylaxis of migraine headache.


Caries activity tests.

Caries activity tests.


Robert I. Kaplan named editor.

Robert I. Kaplan named editor.


Clinical assessment of a new vasoconstrictor agent, octapressin.


The role of fibrinogen in renal disease. I. Production of experimental lesions in mice.


Attenuated rubella vaccination in families: observations on the lack of fluorescent antibody response and on the use of blood collected on filter paper discs in the hemagglutination-inhibition test.


Mental health resources directory. II.

Mental health resources directory. II.


The efficacy of clindamycin in beta-hemolytic streptococcal infections of the upper respiratory tract.


Primary aldosteronism.

Primary aldosteronism.


The implantation of human dentin and cementum with autogenous bone and red marrow into the subcutaneous tissues of the rat.


The role of the clinical laboratory in the community hospital.


Office procedures in the diagnosis of renal disease.


Measurement of lung function in the doctor's office.


The physician's office laboratory in modern medical practice.


Laboratory aids in the recognition of bleeding disorders.


Differentiation of anemias.

Differentiation of anemias.


Modern bedside methods in the diagnosis of heart disease.


Genetics of cultured somatic cells.

Genetics of cultured somatic cells.


Genetic disorders of red cell metabolism.


Genetics and the sphingolipidoses.

Genetics and the sphingolipidoses.


The detection of heterozygous carriers.

The detection of heterozygous carriers.


Pharmacogenetics.

Pharmacogenetics.


Genetic control of hemoglobin synthesis and the thalassemia syndromes.


Human polymorphism.

Human polymorphism.


Treatment of inherited disease: realized and potential.


Genetic effects of radiation.

Genetic effects of radiation.


Genetic counselling.

Genetic counselling.


Genetic consequences of cultural adaptation.


William Beaumont experiments begun 147 years ago this month.


Growth of human foetal tissue in mice treated with antilymphocyte serum.


Reticulum-cell sarcoma of the mandible.

Reticulum-cell sarcoma of the mandible.


Malignant peripheral nerve sheath tumors of the oral cavity. Review of the literature and report of a case.


A short history of the chartered society of physiotherapy.


Studies demonstrating the effectiveness of isoniazid in preventing tuberculosis.


Neutral C19-steroids and steroid sulfates in human pregnancy. V. Isolation and identification of unconjugated testosterone and androstenedione from pooled cord blood.


Intravenous infusion of glucose and sodium bicarbonate in hyaline membrane disease. A controlled trial.


Vascular permeability and leukocyte emigration in allograft rejection.


Combination of bendroflumethiazide and triamterene in the treatment of hypostatic edema.


An attempt towards formalization of psychoanalytic theory.


Investigation of the spasmogenic effect of manganese on the guineapig isolated ileum preparation. 1. The mechanism of the manganese-induced spasm of the guinea-pig ileum was investigated using agents known to modify nerve function. The spasm was reduced by cooling, tetrodotoxin, procaine, Botulinus toxin (Type A), hyoscine and pempidine. It was potentiated by mipafox.2. In the presence of manganese, the release of acetylcholine from the ileum was greatly increased.3. Tetrodotoxin prevented the manganese-induced increase in acetylcholine output from the ileum but had no significant effect on the spontaneous acetylcholine output.4. It is suggested that the manganese-induced spasm of the ileum results from an action on intramural cholinergic nerves.


Muhammad, a psychological essay.

Muhammad, a psychological essay.


Ordinary wool and cotton thread as suture materials in veterinary surgery.


Rehabilitation of burned-face patients.

Rehabilitation of burned-face patients.


Dr. Guy Geoffrey Frederick Newton: obituary.


Dr. Alexander Gourevitch: obituary.

Dr. Alexander Gourevitch: obituary.


Differences between exogenous and endogenous hemopoietic spleen colonies.


Isolation of nuclei from mature peritoneal granulocytes.


Normal and abnormal behavior from learning.


Case histories in 1968 malaria outbreak in Chambers.


The history of L. Richardson Memorial Hospital, Greensboro, North Carolina.


Current approaches to the treatment of narcotic addiction.


Psychophysiological and behavioral effects of phenothiazine administration in acute schizophrenics as a function of premorbid status.


The response of motor neurones to intramuscular injection of botulinum toxin. 1. The dry mass and nucleic acid content of both nerve cell bodies and their nucleoli were measured by interference microscopy and ultra-violet absorption microspectrography respectively: succinoxidase and acetylcholine hydrolase activities were also determined. Autoradiography was used to follow synthesis of deoxyribonucleic acid (DNA) by glial cells, and to follow nucleic acid and protein metabolism in muscle fibres.2. After injection of botulinum toxin the synthesis of ribosomal RNA by the neurone followed closely the pattern found after axotomy.3. After injection of toxin neuronal dry mass increased before the rate of ribosomal RNA synthesis was raised. This early increase, which was not due to increased protein synthesis, probably represents a ;damming back' of proteins within the nerve cell body.4. After injection of toxin no local accumulation of microglial cells synthesizing DNA was found around the affected neurones: it is suggested that this reflects the intact system for intra-axonal transport under these conditions.5. The affected muscles show increased nucleic acid and protein synthesis.6. It is suggested that the results obtained indicate that membrane expansion or synthesis which occurs both in muscle and in neurone under these circumstances is the factor responsible for inducing directly or indirectly the changes found in nucleic acid metabolism after injection of botulinum toxin and after axotomy.


The importance of endotoxin in traumatic shock and shock-resistance.


New York Dermatological Society. First hundred years.


Nutritional regulation of basidiocarp formation and mycelial growth of Agaricales.


History of bullous dermatoses.

History of bullous dermatoses.


Dermatologic therapy. Historical advances.


Bicentennial of King's College first graduation. Ceremony and graduates.


Secondary vertebral deformities in childhood and adolescence.


Spinal deformities in traumatic paraplegics and tetraplegics following surgical procedures.


Evaluation of late spinal deformities with fracture-dislocations of the dorsal and lumbar spine in paraplegics.


Urinary tract disease in spinal cord injury patients. I. A brief outline of the problem.


Motility and multiplication of Mycoplasma pneumoniae. A phase contrast study.


The antibacterial activity of iodine in aqueous solutions of a non-ionic surfactant.


An oxygen-dependent X-ray dose-rate effect in Serratia marcescens.


Residual radiation injury: hematopoietic and gastrointestinal involvement in relation to age.


Portrait of Mr. K.C. Denley.

Portrait of Mr. K.C. Denley.


Tolbutamide tolerance test in post-pancreatitis hypoglycemia.


Some observations on medical education.

Some observations on medical education.


The nature of hypnotic analgesia and placebo response to experimental pain.


Ecology, malnutrition, and mental development.


Electrical stimulation of a human ventrolateral-subventrolateral thalamic target area. I. The stimulation method and the application of repeated stimulus trains of constant composition.


Electrical stimulation of a human ventrolateral-subventrolateral thalamic target area. II. Combination of different durations of single pulses with the peak current just adequate to evoke clinical responses.


Electrical stimulation of a human ventrolateral-subventrolateral thalamic target area. 3. Combination of different pulse repetition frequencies with the peak current just adequate to evoke clinical responses.


Electrical stimulation of a human ventrolateral-subventrolateral thalamic target area. IV. Combination of different pulse repetition frequencies with the pulse duration just adequate to evoke clinical responses.


Epidemiology of rubella.

Epidemiology of rubella.


Rubella: historical aspects.

Rubella: historical aspects.


The effects of chronic hypoxia on the neonatal and infantile brain. A neuropathological study of five premature infants with the respiratory distress syndrome treated by prolonged artificial ventilation.


Raising the threshold in experimental epilepsy by hypothalamic and septal stimulation and by audiogenic seizures.


Ultrastructural changes in the region of the node of ranvier in the rat caused by diphtheria toxin.


The assessment of temporary soft materials used in prosthetics.


The Talma family.

The Talma family.


J. Evangelista Purkynĕ (1787-1869).

J. Evangelista Purkynĕ (1787-1869).


Asymptomatic bacteriuria in girl entrants to Dundee primary schools. During the statutory medical examination on entrance to primary school 943 5-year-old girls were screened for asymptomatic bacteriuria. A prevalence of 2.1% was found. None of the 20 children with asymptomatic bacteriuria was recognized by the parents as having a urinary infection, though 14 of them had symptoms of lower urinary tract infection. In 16 of the children with bacteriuria either the intravenous pyelogram or the micturating cystogram was abnormal. In 12 the height and weight were below the 25th percentile, and in this group the most severe radiological changes were found.Though the significance of asymptomatic bacteriuria is unknown, these results confirm that in this age group it is often associated with a urinary tract abnormality.


Gastric antigens in health and disease. Behaviour in early development, senescence, metaplasia, and cancer. Immunofluorescence studies of the behaviour of gastric antigens in health and disease have shown that during foetal development both gastric and intestinal antigens are present in the gastric superficial mucous epithelium. The intestinal component disappears soon after birth; it re-emerges in senescence and in metaplasia and neoplasia, while the gastric antigen, which normally persists in adult life, is depleted in these circumstances. The loss of adult and the re-emergence of foetal antigen in both metaplasia and neoplasia suggest a possible fundamental relationship between these conditions; the phenotypic variation may reflect cytogenetic liability, which has malignant transformation as a final irreversible step.


A nephelometric pepsin method.

A nephelometric pepsin method.


Solid phase radioimmunoassay for plasma human growth hormone.


The composition and some structural features of the principal gastric glycoprotein.


Culturing beta hemolytic streptococci in pediatric practice--observation after twenty years.


Lung expansion and ventilation during resuscitation of asphyxiated newborn infants.


A clinical trial with live attenuated rubella virus vaccine (Cendehill 51 strain).


Gordon Willard Allport 1897-1967.

Gordon Willard Allport 1897-1967.


A morphologic study of the terminal events of primary antibody response.


A pathogenic interpretation of the lesions of the facial nerve following operations in the middle fossa.


Neuropsychopharmacology and the affective disorders. (First of three parts).


Current concepts: pancreatic extracts.

Current concepts: pancreatic extracts.


Anal streptococci.

Anal streptococci.


Color-additive subtraction.

Color-additive subtraction.


The kinetics of cellular proliferation in normal and malignant tissues. II. An in vitro method for incorporation of tritiated thymidine in human tissues.


Primary lymphoma of the gastrointestinal tract.


Primary lymphoma in the small intestine: problems of roentgenologic diagnosis.


Edwin Charles Ernst, M.D. 1885-1969.

Edwin Charles Ernst, M.D. 1885-1969.


Interposition of ileum as adjunct in abdominoperineal pull-through procedure.


HL-A antigens on human granulocytes studied with cytotoxic iso-antisera obtained by skin grafting.


The usefulness of "Innovar" as an adjunct to local anesthesia in ocular surgery.


Rapid screening tests for the determination of significant bacteriuria in private urologic practice: a comparative study.


Island flap repair of hypospadias.

Island flap repair of hypospadias.


Rudolph H. Kampmeier, MD.

Rudolph H. Kampmeier, MD.


Indications for splenectomy in hematologic diseases.


Evaluation of antithymocyte serum in the treatment of canine renal homografts.


Resuscitation from cardiac arrest due to exsanguination.


A comprehensive approach to the treatment of intraoral and pharyngeal cancer.


Treatment problems in adolescents with anorexia nervosa. Preliminary observations on the second phase.


Parameters of changing metabolism during growth from age 8 to 18, related to physique and body-composition.


Eating disorders in a child population.

Eating disorders in a child population.


The treatment of tendon and nerve lesions in the hand.


The participation of retarded children in junior high academic and nonacademic regular classes.


Dr. Hans Hoff.

Dr. Hans Hoff.


Critical evaluation of Strupp and Bergin. Standard methods needed.


Preliminary results of the Xe133 exploration of the arterial vascularization of the legs.


Virus particles associated with immune responses in Ehrlich ascites tumor cells.


On the technique of methacrylic embedding of samples for ultramicrotomic sectioning.


Antral function in duodenal ulcer. The gastric secretion of acid, chloride and pepsin in response to antral stimuli and to insulin and maximal histamine stimulation in duodenal ulcer and controls.


Stereotactic surgery for the relief of suicidal and severe depression and intractable psychoneurosis.


Salmonella typhimurium pancarditis.

Salmonella typhimurium pancarditis.


Evidence of a foetal role in determining the length of gestation.


New developments in the understanding of the actions of the digitalis glycosides.


Metabolism of digitalis.

Metabolism of digitalis.


Pharmacology of cardiac arrhythmias.

Pharmacology of cardiac arrhythmias.


The use of procaine amide and lidocaine in the treatment of cardiac arrhythmias.


Variables in experimental games: toward a field theory.


Leishmaniasis.

Leishmaniasis.


The autoimmune aspects of pernicious anemia.


Chronic beryllium disease. Long-term follow-up of sixty cases and selective review of the literature.


Exposure of skin grafts for difficult situations.


Prophylactic portacaval anastomosis in cirrhotic patients with esophageal varices and ascites. Experimental design and preliminary results.


Cholesterol metabolism. Effect of temporary complete biliary diversion in man.


The Shwartzman Phenomenon and acute hemorrhagic pancreatitis. A study in dogs.


Physicians and medicare: a before-after study of the effects of legislation on attitudes.


A study of Andrew Jackson's wounds and illnesses.


A clinical appraisal of polyvinyl endotracheal tubes. A study with particular reference to post-operative sore throats.


Teflurane (1,1,1,2-tetra fluoro-bromethane) in clinical use.


Mechanisms of neuromuscular block. A review article.


Recurrent themes in tetanus therapy.

Recurrent themes in tetanus therapy.


Continuous electrophoresis in fluid endless belts.


Ribosomal proteins: VI. Preparative polyacrylamide del electrophoresis as applied to the isolation of ribosomal proteins.


Some factors affecting the fractionation and mobility of RNA in agar gel electrophoresis.


Antilymphocytic antibody: effects in experimental animals and problems in human use.


Ischemic ulcerations of skin and necrosis of muscle in azotemic hyperparathyroidism.


Studies on the epidemiology of resistance (R) factors. I. Analysis of Klebsiella isolates in a general hospital. II. A prospective study of R factor transfer in the host.


Moses Maimonides' aphorisms regarding analysis of urine.


Immunosuppressive drugs in rheumatoid arthritis.


Syndrome of incomplete renal tubular acidosis after cadaver kidney transplantation.


Hyperchloremic acidosis in early diagnosis of renal allograft rejection.


Methionyl transfer RNA synthetase mutants of Salmonella typhimurium which have normal control of the methionine biosynthetic enzymes.


Distribution of pulmonary blood flow after cavopulmonary anastomosis (Glenn operation).


The history of the Irish Medical Association. The Doolin Memorial Lecture.


The goose that laid the golden egg.

The goose that laid the golden egg.


Cardiac preservation. Current methods.

Cardiac preservation. Current methods.


Surgery in Hong Kong.

Surgery in Hong Kong.


Problems with various perfusates for kidney preservation.


Current methods of kidney storage.

Current methods of kidney storage.


Special issue dedicated to Dr. Robert F. Pitts.


Viability assays as applied to the cryopreservation of hearts and kidneys.


The proximal and distal tubular action of adrenal steroids on Na reabsorption.


Electron probe analysis of tubular fluid composition.


Neuropsychopharmacology and the affective disorders (second of three parts).


The course of perinatal mortality: a review of etiologic factors in the Sloane Hospital 1888-1967.


History of the maternal mortality study committees in the United States.


Effect of diazepam on meperidine requirements of patients during labor.


Diazepam (valium) as an adjunct in obstetric analgesia.


Effect of diazepam on labor.

Effect of diazepam on labor.


Experimental investigations on the use of a hallograft (Supramid) in tendon repair operations.


Modified walker.

Modified walker.


Recent developments in transplantation immunology. II.


Mesh tape for skin graft immobilization.


Primary malignant tumors of the hand.

Primary malignant tumors of the hand.


Island flaps in facial reconstruction.

Island flaps in facial reconstruction.


Mechanism of the delay phenomenon.

Mechanism of the delay phenomenon.


The W-plastic versus the Z-plastic scar revision.


The "B.L." bomb-shell (B. Lucas).

The "B.L." bomb-shell (B. Lucas).


Simultaneous neurovascular island flap and flexor tendon transfer to the thumb. Case report.


Current role of tissue typing in organ transplantation.


Cross-thigh flap for bi-malleolar defect.


The development of tissue typing.

The development of tissue typing.


Changing of the guard.

Changing of the guard.


Charles Klaus Stulik 1889-1968.

Charles Klaus Stulik 1889-1968.


Ultrastructure in the canine kidneys preserved for 24 hours.


Mechanical cardiac massage for in vivo preservation of potential renal allografts.


Studies of lipochromes (urochromes) in uremic patients and normal controls I: the elimination of plasma lipochromes by hemodialysis.


The development of microsurgery of the eye.


Current status of dialysis of poisons and drugs.


Artificial circulation--its place and promise.


Studies on immunological unresponsiveness during secondary disease. 3. Effect of donor strain on acquistion of mutual tolerance.


Studies on lymphocytes. XII. The role of immunologically committed lymphocytes in rejecting skin allografts.


The production of isoantibodies in littermate dogs after allogenic skin grafting.


Allograft implants in the anterior chamber of the eye of the rabbit. Early vascularization and sensitization of the host.


The use of the slit lamp surgical microscope in keratoplasty and congenital cataract surgery.


Immunological responses of Pacific hagfish. I. Skin transplantation immunity.


Failure of 6-mercaptopurine to prolong the survival of skin allografts in mice.


Clinical applications of adhesives in corneal surgery.


Replacement of the corneal epithelium with a contact lens (artificial epithelium).


A comparative study of heterologous anti-mouse lymphocyte and antimouse thymocyte sera prepared by two different immunization methods.


Changes in pulsatile blood flow in autograft and homograft kidneys during rejection.


Evaluation of preoperative extracorporeal irradiation of the blood in human renal transplantation.


Histocompatibility of skin grafts from mice of F1, F2, and F3 generations on F1 generation hosts.


Effect of biliary obstruction on skin allograft survival in mice.


Studies on the pathogenesis of atherosclerosis with experimental model systems. I. An electron microscopy study of the effect of artificial fat-emulsion injections into the lumen of doubly-ligated rabbit carotid arteries.


An electron microscopic analysis of gliogenesis in rat optic nerves.


Investigations on the hypothalamo-neurohypophysial neurosecretory system of the grass frog (Rana pipiens) after transection of the proximal neurohypophysis. II. Light- and electron microscopic findings in the disconnected distal neurohypophysis with special emphasis on the pituicytes.


Fine structure of endocrine hindgut cells of a lepidopteran, Ostrinia nubilalis (Hübn.).


Neurosecretion. XV. An electron microscopic study of the corpora cardiaca of Periplaneta americana after experimentally induced hormone release.


The podial pit--a new structure in the echinoid Diadema antillarum Philippi.


Ultrastructure of pituitary lactotropic cells of oestrogen treated male rats.


The morphology of the contact region of vertebrate synaptosomes.


Submicroscopic organization of the otic ganglion of the adult rabbit.


Cardiorespiratory responses to graded positive-pressure breath holding. I.


Acetolysis.

Acetolysis.


Halogenated carbohydrates.

Halogenated carbohydrates.


Experimental alterations of the developmental cytogenetic mechanisms in mulberry silkworms: artificial parthenogenesis, polyploidy, gynogenesis, and androgenesis.


Chromatographic purification of the toxin of type E Clostridium botulinum.


Properties of the crystalline amino acid polymerization factors from Escherichia coli: binding of G to ribosomes.


A chloramphenicol resistant host protein involved in lysogenization.


The stability of beta galactosidase in the presence of urea.


The amino acid sequence of two O-phosphoserine containing tripeptides isolated from the organic matrix of embryonic bovine enamel.


Some physical properties of lysyl and arginyl-transfer RNA synthetases of Escherichia coli B.


Division patterns from single Escherichia coli cells. A method has been worked out for studying the division of single bacterial cells (Escherichia coli B/r) in a uniform environment. Under optimal conditions the daughters of one single cell are found to divide at different times, a fact which indicates that they are not identical. The spread in generation times can be estimated quantitatively. When cells are irradiated with gamma rays in nutrient broth there is an increase in the spread in generation times, and the number of three-cell progeny (which require considerable difference between the daughters) rises. The results are consistent with the idea that damage to a segment of DNA has taken place and that there are three growing points on the DNA at any one time. In nutrient broth there is some evidence for repair of damage. For cells irradiated in minimal medium the pattern is different. The increase in generation times is not so marked, and only slight increase in three-cell progeny is seen. The results suggest that there is the same class of damage to the DNA, with only one growing point present and less repair. Using the criterion that no increase in generation time at all is permitted, we can estimate the total escape probability after radiation. The resulting calculation of critical target size is much closer to the whole bacterial chromosome than is found from normal plating experiments. The behavior of cells that have been exposed to irradiated medium is quite different, involving very long lags and cell death.


J. A. Pocock.

J. A. Pocock.


Sixty years of Stoke Park Hospital (1909-1969).


Electron microscopic studies on Vibrio cholerae: an up-to-date review.


Erythema nodosum.

Erythema nodosum.


The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K 12. Subunit structure of the protein catalyzing the two activities.


The suffering Sewards.

The suffering Sewards.


Immunity and oral disease: a synopsis of the science of immunity.


Levels of hypothalamic luteinizing hormone-releasing factor after exposure to aggression (defeat) in C57BL-6J mice.


Measurement of flow through branched systems using external radiation detectors.


Biological properties of cell wall mucopeptide of hemolytic streptococci. Several of the toxic properties of streptococcal mucopeptide have been studied in detail. Intravenous injection of as little as 1 microg of mucopeptide, solubilized by ultrasonic treatment, elicits a reproducible febrile response. Rabbits which are made tolerant to Escherichia coli endotoxin are only partially tolerant to the subsequent injection of streptococcal mucopeptide. Soluble mucopeptide was successfully employed to prepare and provoke the localized Shwartzman reaction. Intravenous injection of 80 microg of solubilized mucopeptide leads to diffuse cellular infiltration as well as focal areas of myocardial necrosis, surrounded by inflammatory cells.


Cells involved in the immune response. X. The transfer of antibody-forming capacity to irradiated rabbits by antigen-reactive cells isolated from normal allogeneic rabbit bone marrow after passage through antigen-sensitized glass bead columns. The antigen-reactive cells in normal rabbit bone marrow could be isolated from a suspension of marrow cells by passage of the cells through an antigen-sensitized glass bead column. The cells which passed through the column were deficient in antigen-reactive cells directed to the antigen used to sensitize the glass beads, whereas the cells eluted from the column could transfer antibody-forming capacity to irradiated recipients only with respect to the specific sensitizing antigen. Separation of the bone marrow antigen-reactive cells could not be achieved by passage of the cells through nonsensitized glass bead columns or in the presence of excess free antigen in the column. Cells which were retained by, and later eluted from, the antigen-sensitized glass bead columns were mostly small mononuclear cells, whereas cells which passed through the columns were morphologically similar to the original unfractionated bone marrow cell suspension. The data indicate the presence of an antibody or antibody-like structure, with defined immunological specificity, on the surface of the normal bone marrow antigen-reactive cell.


Thermal factors controlling rabbit skin thermoregulatory processes.


Elution parameters of the 99Mo-99mTc generator.


Preliminary examination of bull, ram and rabbit spermatozoa with the stereoscan electron microscope.


Localization of luteinizing hormone-releasing factor in the pre-optic area.


Sperm antigens and their localization within the bovine epididymal epithelium.


Stimulation of release of luteinizing hormone-releasing factor from hypothalamic tissue by dopamine in vitro.


Nematode larva migrans.

Nematode larva migrans.


Host resistance in experimental brucellosis.


Alternate day corticosteroid administration and homograft rejection in rabbits.


Effects of certain hydroxamic acids on L-glutamate 1-carboxy-lyase.


Plasmodium berghei infection in thymectomized rats.


The induction of neurogenic hypercholesteremia.


The pattern of recovery of erythropoiesis in heavily irradiated mice receiving transplants of fetal liver.


Further studies on serum protein formation by chimeras. II. Induction of chimerism with sublethal x-irradiation and heterologous antorgan serum.


Some effects of endotoxin and leukocytic pyrogen on the body temperature of rats.


Allergic encephalomyelitis: inhibition of cellular passive transfer by x-irradiation.


History of the Florida Association for Health, Physical Education, and Recreation--1919 to 1965.


The radiologic diagnosis of tumors of the endocrine glands.


Infertility.

Infertility.


Malaria.

Malaria.


Snape's purging pill for horses--1692.

Snape's purging pill for horses--1692.


Properties of poly-xanthylic acid and its reactions with potentially complementary homopolynucleotides.


Psychopathology of suicide in the formative years.


Some remarks on the attempted suicide in the period of adolescence.


Fragmentation and the "freakish poikilocyte".


Pancreatic glucagon secretion in normal and diabetic subjects.


Carbenicillin therapy of gram-negative bacilli infections.


The association of attainment and sociometric status with reported deviant behaviour in a progessive and a traditional junior school.


Microbial content n non-sterile pharmaceuticals. V. Tablets.


Introductory remarks.

Introductory remarks.


Raymond G. Kuhlen--a tribute.

Raymond G. Kuhlen--a tribute.


Observations on a clinico-therapeutic trial with a new tropical fugicidal agent-Tolnaftate 1 p.c. solution: (brand name in India-Tinaderm) on superficial mycotic infections of the skin.


Effects of food intake on numbers of salmonellae and Escherichia coli in rumen and faeces of sheep.


Breast reconstruction after resection for cancer. Indications and technique.


Results obtained with Gibson's operation (ablation of pathological tissue followed by dermo-epidermal grafts) in the treatment of elephantiasis of the lower extremities.


Foreskin and vulva as ancillary tissue pedicle sources.


The influence of Rauwolfia serpentina crude root on the fasting blood sugar.


An incentive model of rewarding brain stimulation.


Strategies and models of selective attention.


Fetal mortality and morbidity in twin pregnancy.


Human salmonellosis in Jamaica 1962-1966.


Chronic lymph drainage for the control of renal failure and preparation for transplantation.


Experiences with Early Operative Interference in Cases of Disease of the Vermiform Appendix by Charles McBurney, M.D., Visiting Surgeon to the Roosevelt Hospital, New York City.


Effect of salmonella typhi endotoxin on the serum lipid level.


Lasers: their technical, biologic, and air force implications.


Effects of acceleration on human performance and physiology, with special reference to transverse G.


The hypothalamus and pancreas in intestinal function.


Uretero-cystostomy by the method of Sampson-Witzel performed experimentally in the dog without a postoperative ureteral splint or bladder drainage.


Renal-arterio-venous fistula following nephrectomy.


A survey of cerebrospinal fluid cytology.


Pioneer in photomicroscopy.

Pioneer in photomicroscopy.


Stability of erythrocytes fixed in osmium tetroxide solutions.


Stability of brain microtubules in homogenates.


Early treatment of soft tissue injuries of the face.


Fractures of the jaws in children.

Fractures of the jaws in children.


Gross loss of mandibular hard structure.


Nonunion of the mandible and maxilla.

Nonunion of the mandible and maxilla.


Sliding cortical mandibular grafts.

Sliding cortical mandibular grafts.


Treatment of moderately severe erythema nodosum leprosum with thalidomide--a double-blind controlled trial.


Septicaemia in acute leukaemia.

Septicaemia in acute leukaemia.


Sensitivity to spiramycin of thromycin-resistant strains of Staphylococcus aureus isolated from clinical sources.


The diagnosis of asymptomatic bacilluria in pregnancy.


Health and disease in the mining industry.


Degradation of tryptophan messenger. On the degradation of messenger RNA for the tryptophan operon in Escherichia coli.


Direction of in vivo degradation of tryptophan messenger RNA--a correction.


Hybrid anthranilate synthetase molecules from enterobacterial sources.


Natural iso-antibodies specific for tissular group antigens of the colon in dog and rabbit.


Rejection time of kidneys following transplantation in inbred rats.


Separation of anti-inflammatory and immunosuppressive activities in heterologous antilymphocyte serum.


Prof. Dr. Vilém Santholzer is sixty-five.


Site of glucagon in the islets of Langerhans of man as studied by the immunofluorescent technic.


Demonostration of gastrin in the human islets of Langerhans by the immunofluorescent technic.


Phenoxybenzamine in the treatment of septic shock.


Healing of skin incisions with intact subcutaneous muscle closed by non-suture technique. A tensiometric and histologic study in the rat.


The compound arterial graft.

The compound arterial graft.


Gastrointestinal anastomosis with a single layer of continuous catgut.


Value of streptokinase and heparin in treatment of acute deep venous thrombosis. A coded investigation.


Late effects of biliary stasis on the effective liver blood flow.


Vascular patterns in primary and secondary pulmonary tumors in the dog.


Purification and characterization of the multiple forms of beta-galactosidase of Escherichia coli.


Dissociation studies on the toxin of Clostridium botulinum type B.


Human leprosy in normal mice.

Human leprosy in normal mice. It has now been shown that normal mice can be used as models for studying the early stages in the development of leprosy. Inoculation into the foot pads of mice of as few as 10(4) leprosy bacilli leads to infections which spread to distant sites via the blood stream and after two or more years give rise to granulomata and neural damage at the sites of inoculation. Where the tissue response had fully developed it reproduced exactly the histological features of human leprosy in the borderline range.


The control of ribonucleic acid synthesis in Escherichia coli. 3. The functional relationship between purine ribonucleoside triphosphate pool sizes and the rate of ribonucleic acid accumulation.


The control of ribonucleic acid synthesis in Escherichia coli. IV. Relevance of unusual phosphorylated compounds from amino acid-starved stringent strains.


Evidence for one leucyl transfer ribonucleic acid synthetase with specificity for leucine transfer ribonucleic acids with different coding characteristics.


Biochemical studies of the nucleoside analogue, formycin.


Studies on deoxyribonucleic acid polymerase from Ehrlich ascites tumor cells. II. Factors influencing primer and template requirement of deoxyribonucleic acid polymerase.


Amino acid regulation of the rates of synthesis and chain elongation of ribonucleic acid in Escherichia coli.


Polarity of flagellar growth in salmonella.


Studies on the hyperactive child. V. The effects of dextroamphetamine and chlorpromazine on behaviour and intellectual functioning.


Factors affecting the toxicity of oxygen towards airborne coliform bacteria.


The serum antibody response in renal and bladder infections.


Dyspnoea and angina: a clinical study.

Dyspnoea and angina: a clinical study.


The use of the modified PSP excretion test in the clinical management of patients with renal allografts.


Recovery from aplastic anemia associated with infectious hepatitis.


Grant Bramhall Lindeman.

Grant Bramhall Lindeman.


Changing concepts in the care of patients with acute myocardial infarction.


RNA from Salmonella typhimurium hybridizable with R-factor DNA.


The cadaveric kidney in clinical transplantation.


Fifty uremic patients treated with renal homotransplantation.


Anesthesia in renal transplantation. Observations at 142 anesthetics in 50 patients.


The living donor in renal transplantation. Availability, preoperative and postoperative renal function.


Blood flow in kidney transplants. A clinical evaluation of the 133 xenon method.


Urologic complications in renal transplantation.


Angiography of the transplanted kidney.

Angiography of the transplanted kidney.


Comparison of xenon-133 washout curves from the kidney with direct measurement of renal venous outflow.


Renal function and protein excretion in kidney transplants functioning for 6 to 26 months.


Hypertension and sodium retention in bilaterally nephrectomized man.


The function of the drug-modified canine renal allograft.


Low temperature preservation of mammalian kidneys.


Spina bifida cystica. A review of 150 patients.


Surgical repair of skin defect by full-thickness sliding flap (a case report).


Missense suppression in heat-sensitive E. coli-lambda systems.


Outpatient or hospital day-care for minor gynecologic procedures.


Maternal cardiovascular dynamics. IV. The influence of gestational age on the maternal cardiovascular response to posture and exercise.


Immunofluorescent cell-counting assay of Rift Valley fever virus.


Placental hormones and graft rejection.

Placental hormones and graft rejection.


Demonstration of abnormal antigen in bovine lymphosarcoma by immunofluorescence.


Members of the American Orthoptic Council--1969.


1969 Membership roster of the American Association of Certified Orthoptists.


Treatment of convergence insufficiency: a review.


Biostatistical studies. Results of biostatistical study of the management of alternating esotropia with and without orthoptics.


Stereoscopic vision testing: a review.

Stereoscopic vision testing: a review.


Cellular hypersensitivity.

Cellular hypersensitivity.


Human histocompatibility antigens of leukocytes.


Pathological alterations in blood flow.

Pathological alterations in blood flow.


Glucagon.

Glucagon.


Magnesium deficiency.

Magnesium deficiency.


Cell division in normal mammalian tissues.


The structure of the spleen and hemolysis.


Nephritogenic streptococci.

Nephritogenic streptococci.


The epidemiology of St. Louis encephalitis: a review.


Intrarenal blood flow.

Intrarenal blood flow.


Diagnosis of suicidal intent.

Diagnosis of suicidal intent.


Sequential analysis in therapeutic trials.


Assisted respiration.

Assisted respiration.


Proline uptake by disrupted membrane preparations from Escherichia coli.


An interaction between the transfer factors required for protein synthesis.


Effects of photodynamic action on E. coli.


Properties and catalytic activities of omega-hydroxy derivatives of vitamin B6.


The rifamycins--relation of chemical structure and action on RNA polymerase.


The effects of carbon tetrachloride and ethionine on RNA synthesis in vivo and in isolated rat liver nuclei.


Fidelity of genetic code translation in a rat liver ribosomal system.


Polyamines and protein synthesis. 3. The effect of polyamines on the binding of phenylalanyl transfer RNA to ribosomes.


Isolation of biologically active transfer RNA from transfer RNA-DNA hybrids.


T use of membrane electrodes in potentiometric titrations of living cells.


Polyadenylic acid-directed binding of oligolysyl transfer RNA to ribosomes. Inhibition by lysyl and deacylated transfer RNA.


Observations on cardiorespiratory function during caesarean section.


PCO2 control by fresh gas flow during controlled ventilation with a semi-open circuit.


Anaesthesia for an obstetric flying squad.


Studies on lysosomes in rat heart cell cultures. I. The effect of lysosomal labilizers.


Initiation and patterns of transcription during phage development.


Trends in the support of cancer research in the United States.


Rheumatoid arthritis: extra-articular manifestations.


Trends in chemotherapy research.

Trends in chemotherapy research.


Histocompatibility systems of the mouse.


Histocompatibility genes in man.

Histocompatibility genes in man.


Tumour antigens.

Tumour antigens.


Present trends in cancer epidemiology.

Present trends in cancer epidemiology.


Harvey Cushing (1869-1939): a centennial appreciation.


Thenar and palmar-flap repair in finger-tip amputations.


Functional anatomy of the transplanted heart.


Effect of dipyridamole on the incidence of arterial emboli after cardiac valve replacement.


Epicardial ECG in monitoring cardiac homograft rejection.


Prolongation of rat heart allograft function with heterologous antilymphocyte serum.


Human cardiac transplantation.

Human cardiac transplantation.


New method to delineate myocardial damage at surgery.


Sir John Scott Burdon-Sanderson (1828-1905): a pioneer in electrophysiology.


Maturation of the hypothalamic-pituitary-gonadal negative feedback system.


Calcium-magnesium antagonism in insulin secretion by the perfused rat pancreas.


Structural changes in the surface involved in head-to-head association of washed bull spermatozoa.


Age changes in articular cartilage.

Age changes in articular cartilage.


Fluoride treatment of bone rarefaction in multiple myeloma and osteoporosis. A review.


ADP as aid in personnel shortage: enables better use of professionals.


The classics. 1. On the healing of wounds in articular cartilage. P. Redfern, M.D., Edinburgh, member of the Royal Society.


Osteogenetic competence.

Osteogenetic competence.


The role of vagotomy in the surgical treatment of peptic ulcers.


Marked delay in excystment of Schizopyrenus russelli cysts by p-chloromercuric benzoate and its reversal with reduced glutathione.


The classics. II. Healing of cartilage. Sir James Paget, Bart, M.D., London, member of the RYAL Society.


Posterolateral bone graft for nonunion of the tibia.


Infection of the hip as a complication of advanced neurologic disease.


Sedimentation properties of ribonucleic acid from Rhodopseudomonas spheroides.


Delayed multiplication of newly capsulated transformants of Haemophilus influenzae detected by immunofluorescence.


The occurrence of natural antibodies to rumen bacteria.


Studies in isoxazole chemistry. I. 3- or 5-(5-Nitro-2-furyl)-5- or -3-methylisoxazoles.


Synthesis and biological activity of certain 8-mercaptopurine and 6-mercaptopyrimidine S-nucleosides.


Purine nucleosides. XXV. The synthesis of certain derivatives of 5'-amino-5'-deoxy- and 5'-amino-2',5'-dideoxy-beta-d-ribofuranosylpurines as purine nucleotide analogs.


2-benzyl-5-aminolevulinic acid, an analog of glycyl-dl-phenylalanine.


Tetracyclic phenothiazines. II. Antibacterial evaluation of 3-keto-3H-pyrido[3,2,1-kl]phenothiazine-2-carboxylate.


The use of the Adansonian principle in an attempt to characterize strains of gram-negative bacteria isolated from aqueous pharmaceutical preparations.


Plastic hood to facilitate the embedding of small embryos and tissues.


A critical evaluation of the gas chromatographic technique for identification ad determination of fatty acid esters, with particular reference to the use of analog and digital computer methods.


The determination of urea, ammonia, and urease.


Fluorimetric assay of enzymes.

Fluorimetric assay of enzymes.


Salmonella arteritis--preoperative diagnosis and cure of salmonella typhimurium aortic aneurysm.


Donald Darrow Matson.

Donald Darrow Matson.


Rubella diagnosis: the role of the laboratory.


The Hunterian Society. 150th anniversary.


Spina bifida.

Spina bifida.


Dr. Bertram W. Sipp's contributions to medicine.


Bacteria with their coats off: spheroplasts, protoplasts and L-forms.


Electron microscopic study of cell division in M. leprae and M. lepraemurium.


Mechanism of lysozyme action.

Mechanism of lysozyme action.


Talonavicular fusion with bone graft for spastic arthritic flat foot.


San Patricio Veterans Administration Hospital an era is passing by.


A technical note on the viable count of bacteria.


The fluorescent treponemal antibody-absorption (FTA-ABS) test. Development, use and present status. For testing problem sera, the fluorescent treponemal antibody-absorption test (FTA-ABS) is increasingly replacing other treponemal tests for syphilis (including the TPI test) in the USA. The authors review its development as a result of experience with other immunofluorescent techniques and discuss its advantages and disadvantages. Although it is a more sensitive indicator of past or present syphilitic infection than many other widely evaluated techniques, several aspects of the test are still not fully understood; in particular its specificity is not yet established and more information is needed on its reactivity in a variety of clinical diseases and in treponemal diseases other than syphilis. It is a relatively expensive technique in terms of technicians' time, reagents and equipment but there are grounds for hope that research now under way into automation of the procedure may improve the situation.


A new technique for the purification of newly isolated Leptospira strains.


An ultra-rapid apparatus for diagnosing intestinal parasitoses: a larvoocyst detector.


Serological malaria surveys in Nigeria.

Serological malaria surveys in Nigeria. A parasitological and serological malaria survey of 2 large and 2 small areas of Nigeria was carried out in connexion with the activities of the WHO Treponematoses Epidemiological Team.The results, based on data obtained from 1082 subjects, showed that all the areas were holoendemic with the usual pattern of malariometric indices, and that the differences between the parasite rates of the two large areas were due to the different timing of the survey in relation to the seasonal wave of transmission.The fluorescent antibody test was positive (>/=1:20) in 92% of the 914 sera collected from these 2 areas.The serological profile of the population in the 2 areas was similar, but the immunofluorescence titres were higher in all age-groups in the area south of the Benue river, indicating the antibody response to the previous endemic wave rather than the actual amount of transmission taking place at the time of the survey.This study confirms the value of the immunofluorescent technique for large-scale malaria surveys, but indicates the need for caution in interpreting the results and stresses the importance of good knowledge of the local epidemiology of malaria before embarking on application of serological methods.


Atypical mycobacterial disease in British Columbia, 1960-1967.


Russell Claude Brock. A great editor and contributor to the Guy's Hospital Reports.


Myocardial revascularization: a review.

Myocardial revascularization: a review.


Citation of Dr. Robert W. Bates recipient of the Fred Conrat Koch Award for 1969.


Citation of Dr. Richard E. Bailey for the Ayerst-Squibb fellowship for 1969.


The Eli Lilly Lecturer for 1969: Dr. Isidore S. Edelman.


The Ernst Oppenheimer Memorial Award to Dr. Jack L. Kostyo.


Preservation of the isolated heart for 72 hours. A preliminary report on the development of a heart "bank".


Cardiovascular surgery and the kidney.

Cardiovascular surgery and the kidney.


Plasma testosterone-binding affinity and testosterone in umbilical cord plasma, late pregnancy, prepubertal children, and adults.


Electron microscopic study of the beta cells of the islets of Langerhans in rats under an experimentally-induced prediabetic state.


DC defibrillation of atrial fibrillation and its hemodynamical effects, studied by radioisotope dilution method.


Energetics of muscular contraction.

Energetics of muscular contraction.


Thyrocalcitonin.

Thyrocalcitonin.


Methylated ribonucleic acids.

Methylated ribonucleic acids.


Fluorescence as a routine technic in the clinical laboratory.


Double corneal forceps.

Double corneal forceps.


Shakespeare's ophthalmologic vocabulary and concepts.


Louis I. Dublin. November 1, 1882-March 7, 1969.


A selected public health bibliography with annotations.


In Memoriam Dean Harold J. Noyes.

In Memoriam Dean Harold J. Noyes.


Damage to collagen in corneal immune injury. Observation of connective tissue structure.


Controlled evaluation of parenteral diazepam as preanesthetic medication: a statistical study.


On the presence of immunoreactive growth hormone in a bronchogenic carcinoma.


Irreversible thermal denaturation of Escherichia coli ribosomes.


Demonstration of sequence differences in the ribonucleic acids of bacteriophage MS2, and a mutant of MS2.


Properties of transfer ribonucleic acid and aminoacyl transfer ribonucleic acid synthetases from an extremely halophilic bacterium.


Hydrogen-exchange measurements on Escherichia coli transfer ribonucleic acid before, after, and during its aminoacylation.


Electroanesthesia studies: effect of diffuse currents on recruiting response.


Alterations in the structure and function of Escherichia coli alkaline phosphatase due to Zn2+ binding.


Urea biosynthesis. An experimental model for the study of the integration of a metabolic cycle during biological evolution. A review.


The prevalence of fractured dentures. A survey.


The glutamine synthetase deadenylylating enzyme system from Escherichia coli. Resolution into two components, specific nucleotide stimulation, and cofactor requirements.


Action of pepsin on cationic synthetic substrates.


Thoracic trauma and respiratory failure.


The virulence of some strains of BCG for golden hamsters. Although the injection of a large dose of BCG causes progressive, fatal disease in the Syrian golden hamster, not all BCG strains are equally active in this respect. It has been suggested that a strain to be used for vaccinating human beings should not be too weakly virulent in the hamster.Nine BCG strains, some of them widely used for BCG production, were compared with regard to their virulence for hamsters. Five of the strains were found to be of about the same high virulence; the other 4 were less virulent.Of the strains derived from the BCG that was used with success in the BCG trial conducted in Great Britain more than 15 years ago, some are more virulent for hamsters than others. It is suggested that virulence is easily lost but not gained when strains are maintained in vitro. Thus, less virulent strains would have deviated from the original protective strain, and for this reason may be less acceptable for vaccine production.


Experiments with human subjects.

Experiments with human subjects.


Use of alcohol in anesthesia.

Use of alcohol in anesthesia.


Analgesic and other effects of the d- and l-isomers of penzocine.


Cardiogenic shock: a review.

Cardiogenic shock: a review.


Some histochemical observations on the blood cells of six species of turtles.


Dentures, dental care backed as added Medicare benefits.


Sectional dentures--a simplified method of attachment.


A model-surveyor transfer tripod.

A model-surveyor transfer tripod.


Rare tumors of the tonsil.

Rare tumors of the tonsil.


Some observations on eustachian tube inflation.


The foundations of enzyme action.

The foundations of enzyme action.


An analysis of errors in a technique for the combined use of multiple radioisotopes.


Toxic and therapeutic effects of EMTP in obesity.


Salmonellas, shigellas and enteropathogenic Escherichia coli in uncooked food.


A selective motility medium for routine isolation of Salmonella.


Temples are raised in honour of them.

Temples are raised in honour of them.


Indirect band technique.

Indirect band technique.


Lymph vascular system of the interstitial tissue of the testis as revealed by electron microscopy.


Parkes AS: Dr. Herbert M. Evans.

Parkes AS: Dr. Herbert M. Evans.


San Antonio District Dental Society. 1969-1970 membership.


William Pickles.

William Pickles.


Tennessee State Dental Association directory and membership roster, 1969-1970.


Failure of renal transplantation in primary oxalosis.


Alexander Philip Wilson Philip, (1770-1851) experimental physiologist.


Sucrose, the arch criminal of dental caries.


Sulfalene and trimethoprim in acute falciparum malaria.


Letter to the Editor: urges better teaching.


Classical and atypical dentinogenesis imperfecta in a four year old male.


Self-attempted endodontics--a case report.


Two British naval surgeons of the French wars.


Leeds house of recovery.

Leeds house of recovery.


Robert Glynn (1719-1800), physician at Cambridge.


Robert Moffat and the beginnings of the government medical service in Uganda.


Special trays for full denture impressions.


The Lesch-Nyhan syndrome.

The Lesch-Nyhan syndrome.


Medicine and the Roman army: a further reconsideration.


Epidermolysis bullosa--two cases.

Epidermolysis bullosa--two cases.


Hereditary ectodermal dysplasia: report of a case.


Non-odontogenic facial cellulitis--a case report.


Bone and tooth cutting in oral surgery. A review of methods in current use.


In memoriam, Sadao Otani, M.D.

In memoriam, Sadao Otani, M.D.


Practical aspects of current caries research and epidemiological data.


Henry Newell Martin (1848-1893). A pioneer physiologist.


John Huxham.

John Huxham.


The first medical monograph on the gout.


Multiple basal cell naevus syndrome in ancient Egypt.


Compensated dys-perception.

Compensated dys-perception.


The problem of coronary heart disease with special reference to the influence of physical activity.


Enzyme synthesis in synchronous cultures.


Energized configurations of heart mitochondria in situ. Changes in the configurational state of the cristal membranes of rat heart mitochondria within the living cell can be induced by imposing energizing conditions. An exact correlation has been established between the configurational states of the cristal membrane and the energy states of the mitochondrion. The configurational changes observed in mitochondria in situ are comparable to those established for beef heart mitochondria in vitro and are consistent with the postulate of the conformational basis of energy transductions in membrane systems. The formation of paracrystalline arrays is one of the noteworthy features of configurational changes of mitochondria in situ.


Fibrous dysplasia of the orbit.

Fibrous dysplasia of the orbit.


A clinical approach to an effective treatment of the vibrating area.


Periodontal conditions in a Finnish rural population.


Biochemistry and chemistry of lipoic acids.


The use of cultural and histologic methods for the detection of Histoplasma capsulatum in bats: absence of a cellular response.


Treatment of amebic abscess of the liver.


Streptococci, ABO blood groups, and secretor status.


The phylogenic relationships of some Indian tribes of Central and South America.


Dr. Samuel Howard Bartley--a tribute to his long and outstanding career in vision research.


Congenital absence of the pericardium. A review of the literature with demonstration of a previously unreported fluoroscopic finding.


New spring-wound dermatome for skin grafting under local anesthesia.


A new method for semiautomatic suture plication of the inferior vena cava.


The early years of the North Pacific Surgical Association.


Studies in management of the contaminated wound. 3. Assessment of the effectiveness of irrigation with antiseptic agents.


Experimental gastritis in the dog. 1. Production of atrophic gastritis and antibodies to parietal cells.


Respiratory complications of acute pancatitis.


Analysis of the placebo effect and spontaneous changes of airway obstruction in asthmatic patients.


Enzymatic degradation of ribosomal RNA in isolated purified ribosomes.


Genetic mapping of the chl C gene of the nitrate reductase A system in Escherichia coli K12.


Identification of two interchain crosslinks of bone and dentine collagen.


Ribonucleotide reductase in human bone marrow: lack of stimulation by 5'-deoxyadenosyl B 12.


Survey of histocompatibility testing. Biological backgrounds, probabilistic and statistical models and problems.


Factors affecting the flocculation of bacteria by chemical additives.


Cytochemical and immunohistologic investigations on the source and the functional changes of mononuclear cells in skin window exudates.


Effects of radiation on the capacity of the stem cell compartment to differentiate into granulocytic and erythrocytic progeny.


Bi-frontal stereotactic tractotomy: an atraumatic operation of value in the treatment of intractable psychoneurosis.


The use of imipramine ("Tofranil") and other psychotropic drugs in organic emotionalism.


Chromosome complement of lymph node cells in Hodgkin's disease.


Progress in sulfonamide research.

Progress in sulfonamide research.


Financing capital equipment under Medicare.


George E. Goodfellow (1855-1910).

George E. Goodfellow (1855-1910).


The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges.


Studies of deoxycytidylate deaminase from T4-infected Escherichia coli.


Cystathionine gamma-synthase from Salmonella. Beta elimination and replacement reactions and inhibition by O-succinylserine.


Medicare and the teaching hospitals.

Medicare and the teaching hospitals.


Blood group isoantibody stimulation in man by feeding blood group-active bacteria. It was investigated whether or not the human blood group isoantibodies A and B could be induced by immunogenic stimuli via natural routes with a kind of antigenic substance to which all humans are commonly exposed, or if the appearance of these antibodies is independent of antigenic stimuli as has long been believed. Escherichia coli O(86), which possess high human blood group B and faint A activity in vitro, were fed to healthy humans and those with intestinal disorders. 80% of the sick individuals of blood group O and A responded with a significant rise of anti-B antibodies which was frequently de novo in infants; significant increase of anti-A isoantibodies among blood group O individuals was less frequent. Over one-third of the healthy individuals also had a significant isoantibody increase. Intestinal lesions favor isoantibody stimulation by intestinal bacteria; this view was supported by the study of control infants. Persons of blood group A responded more frequently with anti-B and anti-E. coli O(86) antibody production than those of blood group O. Isoantibody increase was accompanied with antibody rise against E. coli O(86). Inhalation of E. coli O(86) or blood group AH(O)-specific hog mucin also evoked isoantibodies. The induced isoantibodies were specifically inhibited by small amounts of human blood group substances. E. coli O(86)-induced anti-blood group antibodies in germ-free chickens and preexisting blood group antibodies in ordinary chickens were neutralized by intravenous injection of E. coli O(86) lipopolysaccharide. This study demonstrates that human isoantibodies A and B are readily elicited via physiological routes, by blood group-active E. coli, provided the genetically determined apparatus of the host is responsive. Antibodies against a person's own blood group were not formed. Interpretation of these results permits some careful generalizations as to the origin of so-called natural antibodies.


Reducing laboratory aerosol contamination.


Patient response to variations in denture technique. I. Design of a study.


Results of a survey of complete denture procedures taught in American and Canadian dental schools.


A review of the practice of prosthetic dentistry in Britain today.


Clinical investigation of dual alloy restorations in teeth with deep subgingival caries.


Erythropoietin alterations in patients with uremia, renal allografts, or without kidneys.


Giant duodenal ulceration.

Giant duodenal ulceration.


Francis Home (1719-1813), practitioner of experimental medicine.


Malaria (1969).

Malaria (1969).


Continuing education courses for physicians.


Gaspare Aselli (1581-1626). The lacteals.


Otto Meyerhof (1884-1951).

Otto Meyerhof (1884-1951).


Subcellular distribution of catecholamines and specific granules in rat heart.


Immunofluorescence microscopy and ultrastructural changes of kidney in experimental anaphylactoid purpura.


The pathophysiology of the dialysis disequilibrium syndrome.


Accumulation of antibody-forming cells in spleens of pre-immunized irradiated mice after transplantation of syngeneic bone marrow.


Localization of parathyroid adenomas by selective venous catheterization and radioimmunoassay.


Henry Rouse Viets, 1890-1969.

Henry Rouse Viets, 1890-1969.


Hyperparathyroidism.

Hyperparathyroidism.


Renal transplantation.

Renal transplantation.


Diploma programs in nursing accredited by the National League for Nursing. School year: September 16, 1969-September 15, 1970.


Excessive gluconeogenesis and oxaloacetate depletion in bovine ketosis.


The green revolution.

The green revolution.


Fortification of bread with iron.

Fortification of bread with iron.


Orotic aciduria.

Orotic aciduria.


Vitamin A deficiency and mitochondrial lipids in rat liver.


Ventriculocisternal perfusion of calves with vitamin A deficiency.


Cellularity of rat adipose tissue in relation to growth, starvation, and obesity.


Diet and mammary gland growth in the pregnant rat.


Mitochondria and cellular activity.

Mitochondria and cellular activity.


Corn-soy-milk, a nutritional supplement.


Capillary hemorrhage in scorbutic guinea pigs.


Dialysis in older patients.

Dialysis in older patients.


Comparative study of a hypnotic and a tranquillizer in anxiety.


Ally of defeat. I.

Ally of defeat. I.


Meprobamate combined with benactyzine.

Meprobamate combined with benactyzine.


Contemporary trends in the analysis of leadership processes.


The barracks and military hospitals of the Cape Peninsula in 1825-1826.


Hyperostosis corticalis infantalis (Caffey's disease).


Samuel Harry Fine, M. B., Ch.B. (Aberd.).


Johannes Philippus de Villiers, C.B.E., E.D., B.A. (cape), M.D., B.Ch., D.P.H., F.R.S.H.


Steatorrhoea and intra-abdominal lymphoma.


Insulin releasing activity of oral L-tryptophan in fasting and non-fasting subjects.


Psychologic considerations in the selection of kidney transplant donors.


Gastric response to secretin and pancreoxymin in man.


Stereotaxic surgery in Parkinson's disease.


Susceptibility of Ateles fusciceps, Ateles geoffroyi and Cebus capucinus monkeys to Plasmodium vivax.


The suppression of malarial parasitaemia by pyrimethamine in combination with dapsone or sulphormethoxine.


Enhanced sensitivity of P. falciparum to sulphalene as a consequence of resistance to pyrimethamine.


Ultrasonic scanning in diagnosis of abdominal disease.


Some laboratory data, including enzymatic observations, in human renal homotransplantation.


Lymphosarcoma of the stomach. A clinical study of 39 cases.


Clinical trial of intramuscular OCM 505 and intravenous methergin in the third stage of labour.


Double blind study of oral chymotrypsin in patients with episiotomy.


Angiographic findings in infratentorial fibromatous meningiomas.


The immediate effect of physiotherapy and water aerosol IPPB treatment on the peak expiratory flow rate in asthmatic patients.


Antigenic cross reactivity of bacterial endotoxins with antibodies to an intestinal polysaccharide antigen in Escherichia coli-associated enteritis in the pig.


Enzymic adaptation in bacteria: its biochemical and genetic basis.


The relation between the direction and mechanism of polymerization.


Ultrastructural study of conjunctival lymphoma.


Electrocardiographic behavior of recipient and donor atria after human heart transplantation.


Sinus arrhythmia in dogs after cardiac transplantation.


Application of fiberoptic dye-dilution technic to the assessment of myocardial function. I. Description of technic and results in 100 patients with congenital or acquired heart disease.


Rubella virus vaccine (HPV-77-DE 5). Antigenic and protective efficacy in a community trial.


The heart in Fabry's disease. A histochemical and electron microscopic study.


Children immunized with HPV-77 rubella vaccine. Additional laboratory observations.


Attenuated rubella virus vaccine in women. Clinical trials during the postpartum period.


Rubella vaccine trials in adults and children. Comparison of three attenuated vaccines.


Transmission of attenuated rubella vaccines to the human fetus. A preliminary report.


Live rubella virus vaccine in tuberculous children.


Attenuated rubella virus vaccines in children with tuberculosis. Clinical trials.


Effect of HPV-80 rubella vaccine on the tuberculin reaction.


Adult women vaccinated with rubella vaccine. A preliminary report on controlled studies with Cendehill strain.


Clinical experience with Cendehill rubella vaccine in mature women.


Prevention of clinical and subclinical rubella infection. Efficacy of three HPV-77 derivative vaccines.


Prevention of rubella during an epidemic on Taiwan. HPV-77 and RA 27-3 rubella vaccines administered subcutaneously and intranasally HPV-77 vaccine mixed with mumps and-or measles vaccines.


Immunofluorescent localization of coxsackievirus B antigen in the kidney observed at routine autopsy.


A fortuitously controlled study of steroid therapy in acute viral hepatitis. I. Acute disease.


Urinary cytology in female genital cancer.


A fortuitously controlled study of steroid therapy in acute viral hepatitis. II. Follow-up examination of 202 patients.


Cervical cytology in folic acid deficiency of pregnancy.


In vitro studies of human trophoblast.

In vitro studies of human trophoblast.


The psychological aspects of the architectural environment: a review.


Metronidazole in the treatment of alcoholism.


The enduring effect of the Jewish tradition upon Freud.


T. E. Lawrence: A study of heroism and conflict.


Private illness and public policy: the cases of James Forrestal and John Winant.


Conflicts in the life of Thomas Jefferson.


Existentialism in American psychiatry--ten years later.


Electrical activity of small intestinal smooth muscle.


Physiology of gastrin.

Physiology of gastrin.


Physiologic mechanisms inhibiting gastric secretion of acid.


Normal and abnormal physiology of the alimentary tract in infancy.


The aging gastrointestinal tract.

The aging gastrointestinal tract.


Effect of endocrine glands on function of the gastrointestinal tract. Study of the thyroid, parathyroid, and adrenal glands.


Bullous skin test response to bacterial antigens.


Topical anesthesia of the tympanic membrane.


Atraumatic biopsy of nasal mucosa.

Atraumatic biopsy of nasal mucosa.


Sensorineural deafness.

Sensorineural deafness.


Oliver St. John Gogarty, MD, FRCSI. Otolaryngologist, statesman, author, and poet.


Serratia marcescens septicemia. A new threat in surgery.


The extended use of skin homografts.

The extended use of skin homografts.


When should renal allografts be removed?


Matching muscles and motoneurones. A review of some experiments on motor nerve regeneration.


Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat.


The carbohydrate metabolism of skin.

The carbohydrate metabolism of skin.


Diabetes mellitus.

Diabetes mellitus.


Chronic granulomatous infection of the legs associated with Corynebacterium acnes.


The effect of methotrexate on skin.

The effect of methotrexate on skin.


Arthur Burrows.

Arthur Burrows.


Theory and practice of colour vision testing: a review. 1.


The health of the Navy: the changing pattern.


Double-blind therapeutic trial of isoniazid in 344 patients with uveitis.


Some observations on appendicectomy with particular reference to technique.


Syngeneic lines of chickens. 3. The number of different histocompatibility loci between the lines.


A simple method for the estimation of number and size of Mycoplasma colonies on agar: its use in the evaluation of colony-CFU ratio.


A specific inactivator of mammalian C'4 isolated from nurse shark (Ginglymostoma cirratum) serum. A material which specifically inactivates mammalian C'4 was isolated from low ionic strength precipitates of nurse shark serum. The C'4 inactivator was not detected in whole serum. The conditions of its generation and its immunoelectrophoretic behavior seem to indicate that it is an enzymatically formed cleavage product of a precursor contained in whole shark serum. The inactivator was partially purified and characterized. It had an S-value of 3.3 (sucrose gradient) which was in agreement with its retardation on gel filtration, was stable between pH 5.0 and 10.0, had a half-life of 5 min at 56 degrees C, pH 7.5, was inactivated by trypsin and was nontoxic. Its powerful anticomplementary activity in vitro and in vivo was solely due to the rapid inactivation of C'4; no other complement components were affected. No cofactor requirement was observed for the equally rapid inactivation of highly purified human and guinea pig C'4. The kinetics of C'4 inactivation and TAME hydrolysis, the greater anodic mobility of inactivated human C'4, and the influence of temperature on the rate of inactivation suggest that the inactivator is an enzyme and C'4 its substrate. This conclusion was supported by the more recent detection of a split product of C'4. Intravenous administration of the C'4 inactivator could prevent lethal Forssman shock and suppress the Arthus reaction in guinea pigs; it prolonged significantly the rejection time of renal xenografts but had no detectable effect on passive cutaneous anaphylaxis. Anaphylatoxin could be generated in C'4 depleted guinea pig serum with the cobra venom factor, but not with immune precipitates. The possible relationship between C'1 esterase and the C'4 inactivator is discussed on the basis of similarities and dissimilarities.


The role of mycobacteria and the effect of proteolytic degradation of thyroglobulin on the production of autoimmune thyroiditis. Data are presented which suggest that the initial event involved in experimental autoimmune thyroiditis following injection of rabbits with homologous thyroglobulin in complete Freund's adjuvant is alteration of the thyroglobulin. Alteration of the thyroglobulin does not occur during incorporation into the adjuvant or in vitro storage in the adjuvant, and the mycobacteria in the adjuvant have no direct effect on the thyroglobulin. Most likely, the alteration results from an increase in hydrogen ion concentration within cells or local areas in the granuloma and the subsequent action of proteolytic enzymes. These conditions are probably established in the granuloma as the result of neutrophilic response to the mycobacteria in the adjuvant. Rabbits injected with aqueous preparations of homologous thyroglobulin partially degraded in vitro with pepsin at acid pH produced antibody to native thyroglobulin and developed thyroiditis. Most of these rabbits responded to a subsequent injection of native thyroglobulin given 1 month later.


Cellular immunity in vitro. Clonal proliferation of antigen-stimulated lymphocytes. When sensitive lymphocytes are cultured with the appropriate antigen, lymphoblasts appear after 24-48 hr of incubation and the number of these increases steadily from the 2nd to the 6th or 7th day. Our problem was to discover, at a cellular level, how this increase takes place; whether it is a massive response of many cells, stepwise recruitment of cells into the lymphoblast class, or simply repeated division of a few cells to form clones. In these experiments lymphocytes were incubated with antigen in culture tubes for 2-4 days and then a few cells, usually less than 200, were transferred to special microchambers for further culture. In these microchambers the cells could be viewed continually with a microscope and their fate recorded over the next 3-5 days by time-lapse cinemicrography. Examination of the film produced in this way showed that lymphoblasts divided and redivided to produce clones of 64 cells or more. It was possible to measure generation times from the film for 301 cells; the majority were between 8 and 13 hr but the range was 7.5-38.0 hr. There was no clear difference between generation times of human lymphocytes stimulated with tuberculin, streptokinase-streptodrnase, extract of the American pokeweed, or in the mixed leukocyte reaction. Similar times were also found for rat cells in the mixed leukocyte reaction. While these observations show that clonal proliferation does occur and could reasonably account for all the increase of lymphoblasts in lymphocyte cultures, the experiments, because of their design, do not exclude the possibility that other mechanisms such as recruitment may play a role as well, particularly during the first 48 hr after contact between sensitive cells and antigens.


Comparative study of abortive and nonabortive rabies in mice.


A tribute to Samuel L. Siegler, M.D. (1898-1953).


Clomiphene citrate in the treatment of luteal phase defects.


Fecal flora in man: effect of cathartic.


Controlled trials with trisulfapyrimidines in the treatment of chronic trachoma.


Bacterial colonization and clinical superinfection of the respiratory tract complicating antibiotic treatment of pneumonia.


Anaerobic bacteria of the gastrointestinal flora and their occurrence in clinical infections.


The story of INH.

The story of INH.


Experimental microvascular autografting. Technical note.


A comparative study of some immunological tests for schistosomiasis before and after treatment.


Enlarged livers and spleens in an area endemic for malaria and schistosomiasis.


Serological reactions to infection with Necator americanus.


The sublethal effects of synthetic insecticides on insects.


Biogenesis of ethylene.

Biogenesis of ethylene.


The biochemistry of nitrifying microorganisms.


Congenital thrombocytopenia with giant platelets: a defect in the platelet membrane.


The effects of phenothiazines on the sickling phenomenon in vitro.


Social class and the utilization of medical care services: a study of British experience under the National Health Service.


Skin allograft and xenograft rejection in the snapping turtle, Chelydra serpentina.


The maturation of the capacity to reject skin allografts and xenografts in the snapping turtle, Chelydra serpentina.


Chronic headaches.

Chronic headaches.


Chlorhydroxyquinoline and di-iodohydroxyquinoline in amoebiasis: a comparative study.


Treatment of hereditary telangiectasia.

Treatment of hereditary telangiectasia.


"Medicine and society".

"Medicine and society".


Complications encountered in head and neck surgery.


Initial urinary tract infections. Observations in children without major radiologic abnormalities.


Arterio-venous fistula of the portal system.


The history of anaesthesia in Edinburgh. I.


Per- and post-operative detection and quantitation of circulatory shunts.


The transplantation argument.

The transplantation argument.


Spontaneous haemorrhage from the middle colic artery. A report of two cases and a review of the literature on splanchnic haemorrhage.


A method for embedding large numbers of simultaneously available automatically processed specimens.


Corticosteroids as an adjunct to treatment in bacterial meningitis. A controlled clinical trial.


Inflammatory response in the neonate re-examined.


Studies on interaction of bacteria, serum factors and polymorphonuclear leukocytes in mothers and newborns.


Renographic and autoradiographic studies during rejection in canine renal allografts.


Behavioural state and seizure susceptibility. A study of responses upon electrical stimulation of the basal temporal lobe in cats under different behavioural conditions.


Tetramisole in the treatment of nematode infections in man.


Pathogenesis of canine distemper.

Pathogenesis of canine distemper.


Skin lesions and shigellosis.

Skin lesions and shigellosis.


Identification of an agent of epizootic diarrhea of infant mice by immunofluorescent and complement-fixation tests.


Fluorescent antibody staining of rabies-infected tissues embedded in paraffin.


A method of isolating Vibrio coli from pigs.


Computer analysis of hippocampal rhythm in hypothermic rabbits.


The release of living phage incorporated in Freund's adjuvant.


Acid and pepsin secretion in response to endogenous and exogenous cholinergic stimulation and pentapeptide.


Base composition and sedimentation properties of mitochondrial RNA of Saccharomyces cerebisiae.


Metal ion-nucleic acid interactions. II. A method for the fractionation of Escherichia coli RNA's into transfer RNA and ribosomal RNA's using Zn2+ or Cd2+ as precipitant.


Specificity of yeast glutamic acid transfer RNA for codon recognition.


Studies on 5-fluorouracil-containing RNA. II. Gross reduction of 4-thiouracil in fluorouracil-containing tRNA from Escherichia coli.


Fractions of RNA and ribonucleoprotein from bacterial polysomes. I. Isolation of polysomes from Escherichia coli.


Interaction of informational macromolecules with ribosomes. I. Binding of labeled nuclear RNA by rat liver ribosomes.


Inhibition of the synthesis of 5-S ribosomal RNA in Escherichia coli by levallorphan.


Conformation of denatured and renatured DNA.


Repression by arginine in Escherichia coli: a comparison of arginyl transfer RNA profiles.


Nucleotide sequence of oligonucleotides derived from Escherichia coli valine transfer RNA by ribonuclease T1 digestion: comparison of the sequences neighboring 3'- and 5'-terminals and anticodon region of Escherichia coli valine transfer RNA with those of yeast valine transfer RNA.


Experience with a simplified method of radio-isotopic assay of serum vitamin B 12.


Induction of intravascular coagulation and renal cortical necrosis in rabbits by simultaneous injection of thorotrast and endotoxin.


Kinetics of the alteration and modification of DNA-dependent RNA-polymerase in T4-infected E. coli cells.


Specificity and function of exonuclease II in the synthesis of alternating copolymers by DNA polymerase.


Clinical experience in the treatment of gastrointestinal gas.


Further studies on mitosis of bi- and multinucleate HeLa cells.


Clinical trial with atmospheric oxygen breathing during radiotherapy of cancer of the cervix.


Bronchial lavage in the treatment of asthma.


Transplantation of the heart and both lungs. II. Experimental cardiopulmonary transplantation.


Effect of chest physiotherapy on blood gases of neonates treated by intermittent positive pressure respiration.


Starvation effects on the ultrastructure of amoeba mitochondria.


Action of reserpine on the osmium tetroxide zinc iodide reactive site of synaptic vesicles in the pineal nerves of the rat.


The fine structure of the olfactory tract in the teleost Carassius carassius L.


Accumulation of organelles at the ends of interrupted axons.


Light microscopy of glial cells in turtles and birds.


An electron microscope study of cells in the matrix and intermediate laminae of the cerebral hemisphere of the 45 mm rabbit embryo.


Fine structure and absorption patterns of intestinal epithelial cells in rainbow trout alevins.


Enterochromaffin cells in the chicken duodenum during prenatal development.


An electron microscopic investigation of the sensory organs in the hard palate region of the hen (Gallus domesticus).


Studies of adrenocortical ultrastructure. 2. The interrenal cell of the domestic fowl as seen after glutaraldehyde perfusion fixation.


Studies of adrenocortical ultrastructure. 3. Effects of dexamethasone and medroxyprogesterone on interrenal cells of the domestic fowl.


Electron microscope study of the developing nerve terminals in the acoustic organs of the chick embryo.


The occurrence of intramitochondrial granules in nerve cells.


The demonstration of chloride ions in the "chloride cells" of the gills of eels (Anguilla anguilla L) adapted to sea water.


Formation, transport, and storage of ribonucleic acid containing structures in oocytes of Acheta domesticus (Orthoptera).


Fine structure of the protonephridial system in Planaria. I. Flame cells.


Fine structure of the protonephridial system in Planaria. II. Ductules, collecting ducts, and osmoregulatory cells.


Scanning electron microscopy of cementum and Sharpey fibre bone.


The effect of metopirone and aldactone on the interrenal tissue of intact and pars distalis-ectomized common frogs, Rana temporaria.


Ultrastructural characteristics of the thyroid C cells in the summer, autumn and winter states of the hedgehog (Erinaceus europaeus L.), with some reference to other mammalian species.


Electronmicroscopical observations on yolk and yolk formation in Ophryotrocha labronica LaGreca and Bacci.


Histology and ultrastructure of the neural lobe of the lizard, Klauberina riversiana.


Treatment of cardiogenic shock.

Treatment of cardiogenic shock.


Serum enzyme determinations: their reliability and value.


The recognition and treatment of adrenal crisis.


Genetic and environmental factors in profound prelingual deafness.


Metabolic disorders of the ovary.

Metabolic disorders of the ovary.


Heteroblastic development in vascular plants.


The ultrastructure of the nucleus of the developing amphibian egg.


The biology of teratomas.

The biology of teratomas.


The development of patterns in the integument of insects.


Multiple progressive intracranial arterial occlusions: a syndrome of children and young adults.


Calcitonin and parathyroid hormone.

Calcitonin and parathyroid hormone.


Use of cell culture in pharmacology.

Use of cell culture in pharmacology.


Statistical approach to evaluating the method of Morgan and Vryonis for enumerating Treponema pallidum. The contributions of four components to the error in the microscopic enumeration of spirochetes (Treponema pallidum) by the method of Morgan and Vryonis were determined. Where N(s) = the number of slides counted, N(r) = the number of recounts of 50 fields per slide, N(p) = the number of pipettes used, and N(e) = the total number of counts of 50 fields made, the coefficient of variation is 2 times the square root of (17.5(2)/N(s) + 18.6(2)/N(r) + 14.8(2)/N(p) + 6.1(2)/N(e)) with 95% confidence.


Intracellular survival of viral and rickettsial agents in acetone at -60 C. Viral and rickettsial agents, located intracellularly in cell monolayers, varied in their ability to survive exposure to acetone at -60 C.


The isolation of neurons from normal and abnormal human cerebral cortex.


Modern indications for tracheotomy in cases of acute and chronic asphyxia.


Cervical adenopathies.

Cervical adenopathies.


Transplantation of allogeneic canine bone marrow stored at -80 degrees C in dimethyl sulfoxide.


Adverse reactions to drugs in a dermatology ward.


An operation for pruritus; pruritus in secondary hyperparathyroidism.


The role of Clostridium novyi in bovine disease in Alberta.


Structure of chromosomes. I. Morphological studies of the spiral structure of human somatic chromosomes.


Measurement of cardiac output by thermodilution: theoretical considerations and practical aspects.


Sodium recovery from normal and edematous lungs studied by indicator dilution curves.


Aortic stenosis.

Aortic stenosis.


Climatology and medicine.

Climatology and medicine.


A comparison of the analgesic effects of profadol and morphine in patients with cancer.


A double-blind controlled trial of clofibrate in the treatment of diabetic retinopathy.


A statistical solution to an ethical problem.


Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.


Regional enteritis.

Regional enteritis.


Progress in ophthalmological instruments.


Retinal circulation in high blood pressure.


Intraocular foreign bodies. Magnet extraction.


Psychosomatics: the second face of ophthalmology.


A pump system for performing indicator-dilution curves without blood loss.


Ribonucleic acid within the extracellular matrix during embryonic tooth formation.


Some aspects of interneuronal connections cat's spinal gray matter.


Secretion of C19-steroids and oestrogens in the polycystic ovary syndrome: production and secretion rates measured by isotope dilution in urine.


Continuous flow culture of mixtures of faecal organisms.


Correlation of sensitivity to ionizing radiation and mild heating in bacteria.


Cervico-oculo-acoustic dysplasia. ("The syndrome of Wildervanck").


The effect of a mouthwash as adjunct in tooth cleaning.


The anomalous distribution of body water under an alkaline osmotic stress in hypothyroid dogs.


Mechanical circulatory assist techniques in the treatment of cardiogenic shock.


A comparison of a single dose and a five-day course of tetracycline therapy in bacillary dysentery.


Bernhard Naunyn (1839-1925), clinician, teacher, scientist.


Dental auxiliary utilization program.

Dental auxiliary utilization program.


The final medical treatment of two United States presidents (George Washington and Dwight David Eisenhower).


Research in muscular dystrophy.

Research in muscular dystrophy.


Full-thickness grafts in deep lamellar beds.


Necrosis of anterior pituitary in humans. II.


The action of dexamethasone and vasopressin on hypothalamic CRF production and release.


Purification of a growth hormone-inhibiting factor (CIF) from sheep hypothalamus.


Renal and extrarenal erythropoietin in man.


Induction of running activity by intracerebral implants of estrogen in overiectomized rats.


Unite and fight.

Unite and fight.


Raise the roof.

Raise the roof.


Pathogenesis of ascites in cirrhosis of liver. II.


The fundamental lesion in subclinical diabetes.


Richard Herman Jaffé.

Richard Herman Jaffé.


Proinsulin: the precursor of insulin.

Proinsulin: the precursor of insulin.


Pathobiology of the islets of Langerhans.


Phobias of childhood: etiology and treatment.


Attribution of intent.

Attribution of intent.


Modification of smoking behavior: an evaluative review.


My image of the retina.

My image of the retina.


Biophysical contributions to membrane structure.


The stereochemical code and the logic of a protein molecule.


Infectious diseases. Annual review of significant publications.


Porphyria and King George 3rd.

Porphyria and King George 3rd.


Ovarian tumors with endocrine activity and related problems.


Present status of the diagnosis and treatment of Cushing's syndrome.


Newer considerations in the diagnosis and management of fasting hypoglycemia.


Initiation and termination of DNA replication after amino acid starvation of E. coli 15T-.


Molecular recombination in the ligase negative T4 amber mutant.


Fellows of the College of Physicians of Philadelphia.


Therapeutic effects of flumethasone in swine.


Acquisition of the K-12 F+ male state and the f+ antigen by shigella flexneri strains.


Immunohistochemical demonstration of rheumatoid factor (RF) in alcohol-fixed synovial tissue from patients with rheumatoid arthritis (RA).


Bacterial flora of the conjunctiva and lid margin. Effects of parenteral trisulfapyramidines and topical tetracycline and erythromycin.


Early cryosurgical chorioretinal microcirculatory changes.


Immunoglobulin G in the rabbit cornea.

Immunoglobulin G in the rabbit cornea.


Corneal thickness: postoperative changes in refrigerated and cryopreserved corneal grafts.


Guinea pig asparagine synthetase.

Guinea pig asparagine synthetase.


A stereospecific 2-keto-4-hydroxyglutarate aldolase from Escherichia coli.


The chitinase of Serratia marcescens.

The chitinase of Serratia marcescens.


The chemical composition of the cell envelope of Streptobacillus moniliformis.


The cytological effects of myxin on Escherichia coli.


Uptake of pimelic acid by Escherichia coli and Pseudomonas denitrificans.


Studies on Stigmatella brunnea.

Studies on Stigmatella brunnea.


Galactorrhea.

Galactorrhea.


The binding of peptidyl-tRNA and acylaminoacyl-tRNA to E. coli ribosomes.


The structure of the erythrocyte membrane.


Oxygen exchange in the erythrocyte.

Oxygen exchange in the erythrocyte.


Hemoglobin.

Hemoglobin.


Nucleolar changes in non-growing and growing lemon fruit explants (Citrus limon L.).


Literature reveals problems with contamination. Here is a procedure to use for bacteriological sampling.


Foetal blood vessels on the chorial surface of the human placenta in abnormal pregnancy and development.


Health programs and the Nixon Administration.


Laboratory diagnosis of mycobacteria.

Laboratory diagnosis of mycobacteria.


An investigation of the tremorgenic effects of oxotremorine and tremorine after stereotaxic injection into rat brain.


Characteristics of cultured lens epithelium.


Function of insect compound eyes containing crystalling tracts. Image formation is studied in compound eyes of insects that contain crystalline tracts. In optical experiments the course of light is studied in fresh scalps of dark-adapted eyes using point and extended sources. In the tract region a point source gives a diffusely lighted area within which are punctate spots about 10 times brighter. Because the position of these spots does not change when the source is moved, and because their spacing agrees with estimates based on the known scalp depth, we conclude that these spots represent light radiating from the cut ends of tracts. An extended source gives a dim erect image in the tract region that may come from the pattern of illumination radiating from the cut ends of the tracts. In electrophysiological experiments intracellular microelectrode recordings of responses to illumination are made from single retinular cells of the skipper, Epargyreus clarus, an animal that lacks iris pigment. Measurements of visual fields of single retinular cells by three methods give half-power beam widths of about 2 degrees . Though not conclusive, these experiments suggest that only the light contained in the tract is effective in stimulating the retinular cell. This agrees with the theoretical study of Allen (1968) and is inconsistent with the superposition theory of Exner (1891) as applied to certain moth and skipper eyes.


Complement metabolism in man: hypercatabolism of the fourth (C4) and third (C3) components in patients with renal allograft rejection and hereditary, angioedema (HAE). Highly purified and radioiodinated human C4 and (or) C3 were administered to patients with renal allografts in rejection, with hereditary angioedema (HAE), with chronic glomerulonephritis, and to control subjects. The latter group included normal individuals, anephric patients before transplantation, and stable renal allograft recipients. The catabolic rates of these complement proteins were determined by analysis of the disappearance of plasma protein-bound radioactivity (k(m)), and by direct measurement of urinary excretion of radioactivity (k(u)). The correlation coefficient between these two methods was 0.96. The mean +/-2 SD for catabolic rates in the control subjects was 0.9-2.7% plasma pool/hr for C4 and 0.9-2.0% plasma pool/hr for C3. Patients experiencing renal allograft rejection had unstable levels of C4 and C3, and exhibited moderate hypercatabolism of both proteins. One patient with chronic glomerulonephritis had hypercatabolism of C4 and C3 in the presence of stable normal serum levels. In patients with HAE who had extremely low levels of C4, catabolic rates for C4 were markedly elevated (3.7, 5.8, 7.0 and 8.8%/hr). Analysis of plasma curves in HAE revealed a three component disappearance curve instead of the two component curve in control subjects receiving the same preparation. Even though C3 levels were normal, moderate hypercatabolism of C3 was also present in HAE (2.6, 2.8, 2.8, and 3.2% of pool/hr). The marked hypercatabolism of C4 in HAE constitutes the first direct evidence for the in vivo destruction by uninhibited C1 esterase of its natural substrate C4. The moderate hypercatabolism of C3 is consistent with the in vivo formation of C3-convertase.


In vitro transformation by an avian adenovirus (CELO). II. Hamster kidney cell cultures.


The philosophical roots of medicine and biology. A historical approach toward a philosophy for the life sciences.


Alonzo de Grate Smith, M.S., M.D., 1890-.


Bile salt enhancement of riboflavin and flavin mononucleotide absorption in man.


Principles of tympanoplasty and their technical application.


Alfred Sydney De Bohun Cocks.

Alfred Sydney De Bohun Cocks.


Giardia lamblia as parasite in humans.

Giardia lamblia as parasite in humans.


Man's early challenge to neoplasms.

Man's early challenge to neoplasms.


Polyacrylamide-gel electrophoresis of cell proteins of Enterobacteriaceae. A possible taxonomic aid.


The control of aerial contamination in field surgical unit operating theatres.


A royal obstetric tragedy and the epitaph.


The relief of pain with an antidepressant in arthritis.


A controlled trial of laxatives in geriatric patients.


The xenograft rejection phenomenon. I. Response of the mouse to rabbit, guinea pig and rat skin xenografts.


Clinical trial of "onadox-118" in general practice.


Ally of defeat. II.

Ally of defeat. II.


Distal tubular dysfunction after cadaver kidney homotransplantation.


Isolation and some properties of the radiation-sensitive mutant of S. typhimurium LT 2.


Inhibition of tumor growth by polyinosinic-polycytidylic acid. The synthetic double-stranded RNA, polyinosinic-cytidylic acid, inhibits the growth of some tumors in mice. Two days after implantation of a reticulum cell sarcoma, a lymphatic lymphoma, a fibrosarcoma, two leukemias, and a human adenovirus 12-induced tumor, treatment of groups of mice resulted in decreased growth rates of the tumors and increased survival times of the animals. In the two tumors tested (the reticulum cell sarcoma and the adenovirus 12-induced tumor) initiation of treatment after the tumor was grown to moderate size caused a regression of the tumor. In the case of the reticulum cell sarcoma, the tumor had not reappeared in some of the animals two months after cessation of treatment.


The molecular origin of lambda prophage mRNA. Lambda-specific RNA extracted from lysogenic bacteria hybridizes specifically with fragments of lambda DNA containing 43 per cent GC (guanine plus cytosine). Therefore genes known to function in the prophage state (c(I) and rex) lie 0.38 +/- 0.08 fractional molecular length from the right end of the lambda DNA molecule, according to the compositional map of Skalka, Burgi, and Hershey.


Increment of average fitness for multiple alleles. When the various genotypes (A(i)A(i), A(i)A(i)) of an autosomal locus do not reproduce and contribute equally to the genetic composition of the next generation, we say that the "fitness" values of the genotypes are different, or that there is natural selection on the genotypes. Under natural selection, the average fitness for a random mating population increases with time until a stationary state is reached. This communication gives a general expression for the amount of increase of the average fitness per generation of selection. It was found that the amount of increase depends largely on the linear or additive component of the variance of the genotype fitness values and, to a lesser extent, on the dominance pattern for the values of heterozygote fitness relative to those of homozygote fitness.


Nucleoside triphosphate pools and the regulation of RNA synthesis in E. coli. Amino acid starvation of "stringent RNA control" (RC(str)) strains of Escherichia coli (E. coli) results in the cessation of net protein and net RNA synthesis, whereas "relaxed RNA control" (RC(rel)) strains continue net RNA synthesis under the same conditions of amino acid starvation. This report tests further the hypothesis that net RNA synthesis is markedly reduced during amino acid starvation of RC(str) strains as a result of reduction in the supply of substrates of the RNA polymerase. Bacterial ribonucleoside triphosphate pool levels were measured before and after the arrest of protein synthesis in RC(str) and RC(rel) strains. Protein synthesis was inhibited either by addition of trimethoprim to the medium or by the use of a mutant having a temperature-sensitive valyl-tRNA synthetase. The ribonucleoside triphosphate pool levels do not decline significantly during inhibition of protein synthesis in RC(str) strains under either condition, and there is no apparent correlation between the measured pool levels and the residual rate of net RNA synthesis in RC(str) and RC(rel) strains. Thus, these data argue against the hypothesis that the regulation of RNA synthesis is mediated by the availability of substrates of the RNA polymerase.


DNA-directed peptide synthesis. VI. Regulating the expression of the lac operon in a cell-free system. The operon model was proposed by Jacob and Monod in 1961 to explain the regulation of enzyme synthesis in bacteria. The model requires two genetic elements: a locus i which directs the synthesis of a repressor, and a locus called the operon which contains an operator gene and associated structural genes. The repressor is believed to stop RNA and enzyme synthesis by combining with the operator site. The inhibiting effect of the repressor is reversed by an inducer which interacts directly with the repressor. A DNA-dependent cell-free system has been developed for studying the regulation of the operon containing the gene for beta-galactosidase enzyme. In this cell-free system, gene activity is indirectly measured by the synthesis of part of the enzyme. Qualitatively, the regulation of the operon in the cell-free system is similar to its regulation in intact cells. The cell-free system is used to advantage in experiments where it is desirable to use predetermined levels of repressor, operon, and inducer. Such quantitative studies suggest that two inducer molecules are most effective in removing the repressor from the gene.


The effect of tRNA concentration on the rate of protein synthesis. Two in vitro protein-synthesizing systems derived from E. coli have been utilized to demonstrate that the concentration of a tRNA species can regulate the rate of translation of a messenger RNA. (a) The rate of poly-U-directed C(14)-phenylalanine incorporation into protein is stimulated by concentrations of tRNA(Phe) from 1.5 x 10(-8) M to 3.0 x 10(-6) M, the latter representing a tRNA(Phe)/70S ribosome ratio of 7. (b) The rate of translation of poly A,G in a S-30 protein-synthesizing system derived from E. coli is limited by the amount of tRNA(Arg) recognizing the codewords AGA and AGG present in the extract. Polypeptide synthesis can be stimulated in direct proportion to the amount of this tRNA(Arg) species added to the reaction mixture. A mechanism for regulating the rate of protein synthesis at the translational level may be the slowing of polypeptide chain propagation at certain codons due to the presence of rate-limiting tRNA species.


Physiological role of 70S ribosomes in bacteria. Evidence is presented indicating that free 70S ribosomes are real components of Bacillus stearothermophilus and Escherichia coli in exponential and stationary phases of growth. After pulses of radioactive leucine or uracil were given, protein synthesis was instantaneously stopped by chloramphenicol, or polypeptide growth was allowed to proceed to completion in slowly cooled cells. Analysis of label distribution in sucrose gradients showed that 70S monomers, and not subunits, are final products of translation.A ribosome cycle for protein synthesis in bacteria is proposed.


Caucasian genes in American Negroes.

Caucasian genes in American Negroes.