Imported malaria in the United Kingdom.

Imported malaria in the United Kingdom. Over 2,000 cases of imported malaria have been confirmed by blood examination. Ninety percent. of cases from tropical Africa were infected with P. falciparum. Most of the patients were Caucasians and had primary infections. All developed fever within a month after arrival and most of them within two weeks of arrival. In some patients malaria parasites were seen in routine blood films.Developing forms of P. falciparum were always present in the peripheral blood of patients suffering from a primary attack which was not diagnosed or treated until a week or more after the onset of fever.All deaths investigated were caused by P. falciparum and were primary infections.In not one of the P. falciparum infections did the victim continue taking prophylactic drugs for more than a few days after leaving the endemic area. Had drugs been continued for one month probably not a single overt case of P. falciparum would have occurred.A primary attack of P. falciparum malaria is seldom, if ever, classical in that the fever is never tertian and may resemble clinically many other diseases.Children in boarding-schools returning from the tropics should be supplied with prophylactic tablets and instructions to the matron. If there is an epidemic of a fever any students who have recently returned from the tropics should have a blood film examined for malaria.The risk of contracting malaria among drug addicts is considerable, especially with P. falciparum.


Neuropsychiatric complications of hepatic failure.


Determination of myocardial blood flow in the anesthetized dog after a bolus of 84Rb.


Edward P. Bagg, Jr., M.D.

Edward P. Bagg, Jr., M.D.


The centennial of the Massachusetts Department of Public Health.


Current concepts. The structure of cell membranes.


The infection of Escherichia coli by T2 and T4 bacteriophages as seen in the electron microscope. 3. Membrane-associated intracellular bacteriophages.


A role for phospholipid hydrolysis in the lysis of Escherichia coli infected with bacteriophage T4.


Strains of phage lambda in current use.

Strains of phage lambda in current use.


A possible role of C3 gene of lambda prophage in the maintenance of the lysogenic state.


The inability to alter limited heterocatalytic expression in phage T4-infected Escherichia coli by growth of host cells under various physiological conditions.


A double-blind study of Trasylol in the treatment of pancreatitis.


Enzymatic activities on cell walls in bacteriophage T4.


Tendon injury of the hand.

Tendon injury of the hand.


Survivorship following heart transplantation in Canada.


Purification and properties of the 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (phenylalanine sensitive) of Escherichia coli K12. I. Purification of enzyme and some of its catalytic properties.


Medicine's logo.

Medicine's logo.


An attempt to evaluate a rapidly acting oral analgesic.


Model maps for experimental spinal cord stereotaxis.


Biochemical and histopathological studies of the carrier state in Duchenne's muscular dystrophy.


Operative complications due to stereotactic surgery.


The overall information carrying capacity of the major afferent and efferent cerebellar cell and fiber systems.


The inflammatory diseases of the large and small bowel.


Effect of actinomycin D on the inhibitory response of estrogen on LH release.


Effect of GH-releasing factor and GH-inhibiting factor on the release and concentration of GH in pituitaries incubated in vitro.


Slip-knot buried sutures for cataract extraction.


Dexamethasone nasal aerosol vs. placebo in the treatment of nasal polyposis.


Blood flow and intravascular phenomena in the microvascular system.


Separation of oligonucleotides derived from the phenylalanine transfer ribonucleic acid of Escherichia coli B by thin-layer techniques.


Serotyping and the Dienes reaction on Proteus mirabilis from hospital infections. The serotype of 320 strains of Proteus mirabilis from clinical material was determined. Using 20 O antisera and four H antisera 61% of strains could be fully identified and 90% partially identified. A large number of serotypes were recognized but no difference was found between the serotype of organisms infecting the urinary tract and those from other infections. Biochemically identical organisms found in the same ward generally differed in serology. Proteus mirabilis was isolated from the faeces of 84.5% of 84 patients with urinary infection and from none of 20 normal controls. By serology and the Dienes test 61% of the organisms isolated from the urine and faeces of a single patient were identical, indicating that infection arose from the intestine. Most groups of serologically identical strains could, by the Dienes test, be further divided into a number of subtypes indicating that the strains were different and that cross infection had not been responsible for their spread. With three serological groups, however, the majority of strains belonged to a single Dienes type and it was concluded that these organisms had been spread from a common reservoir or carrier. Because of the unreliability of the Dienes test when carried out on random organisms it is suggested that reliable results can only be obtained by combining the Dienes test with serotyping.


Economic and laboratory considerations in screening for vitamin B12 deficiency in psychiatric practice. Two alternative methods for detecting vitamin B(12) deficiency in a psychiatric population have been compared: the ;direct' approach by microbiological assay of serum vitamin B(12) levels in all patients, and the ;indirect' approach where all patients are first screened for antigastric parietal cell antibodies and thereafter all positive reactors and other ;high-risk' patients have serum vitamin B(12) assayed. The indirect approach was found to be cheaper.


Immunofluorescent localization of Tamm-Horsfall mucoprotein in human kidney. A fluorescein-labelled antiserum to human Tamm-Horsfall mucoprotein applied to frozen human kidney sections gave strong specific labelling, mainly of cells of tubules in the outer medulla. By comparison with adjacent serial sections stained for alkaline phosphatase and succinic dehydrogenase, it is suggested that material reacting immunologically as Tamm-Horsfall muco-protein is found particularly in the cells of the ascending limb of the loop of Henle and the macula densa segment of the distal tubule.


Value of streptokinase and heparin in treatment of acute deep vein thrombosis.


Thrombolytic therapy in coronary thrombosis.


A note on the relation of parental dominance as a decision maker in the home to children's ability to make sex-role discriminations.


The treatment of deep vein thrombosis.

The treatment of deep vein thrombosis.


Fantasy confession among Arapaho Indian children.


Carcinogen-induced tumors of the thymus. II. Lung colonies as a means of separating different cell types of a functional thymoma.


Transplantation behavior of Hodgkin's-like reticulum cell neoplasms of strain SJL-J mice and results of tumor reinoculation.


A video system for recording dynamic radioisotope studies with the Anger scintillation camera.


Rapid sequential kidney scanning with 131-I-hippuran.


Measurement of blood volume using red cells labeled with radioactive carbon monoxide.


Analysis of precordial isotope dilution curves obtained after antecubital and intracardiac injection.


Prognostic value of radioisotope renograms in kidney transplantation.


Klebsiella pseudomembranous enterocolitis. Report of two cases.


Some data on the life and activities of Andreas Schnerch, 1765-1853.


The relationship of neonatal nutrition to brain growth.


Development of controlled cardiac pacemaking.


Plasmodium falciparum malaria.

Plasmodium falciparum malaria.


James Hadfield and medical jurisprudence of insanity.


Elias Lönnro, M.D. (1802-1884). The Kalevala.


Persistent neonatal hypoglycaemia: a case report.


Observations on the stereotaxic configuration of the hypothalamus nuclei in the sheep.


The New York Academy of Dentistry. Fellowship List. Active Fellows.


Clinical trials of Jonit (Hoechst 16 842) in the treatment of Necator americanus infection in Thailand.


Blood glucose and serum insulin levels in children with cystic fibrosis.


William Stanley Wilkinson, B.D.Sc., D.D.S.


Some properties of transfer ribonucleic acids from 5-fluorouracil-treated Escherichia coli.


The surgical treatment of palmo-plantar keratoderma.


Electron microscopic observations on the lesions of condyloma latum.


Lady Mary Wortley Montagu--eighteenth century crusader.


Robert James Graves, physician, educator, scientist.


The age of menarche in Classical Greece and Rome.


Effects of chloral hydrate on the respiration of nonasthmatic and asthmatic patients.


Laboratory diagnosis of hog cholera in Missouri.


The serum bactericidal reaction. 3. Antibody and complement requirements for killing a rough Escherichia coli.


The enhancement of antibody formation by Escherichia coli lipopolysaccharide and detoxified derivatives.


Immobilizing antibodies in pyelonephritis.


Inhibition of macrophage migration by a skin-reactive polysaccharide from BCG culture filtrates.


The effect of antilymphocytic serum (ALS) on the reticuloendothelial system (RES) of mice.


Interpretation of disc sensitivity tests on organisms of intermediate sensitivity.


Semi-automation of rapid paraffin processing.


Methylene blue sensitivity of vibrio organisms.


The ultimate consumer in nuclear medicine. The nuclear pioneer lecture of the Society of Nuclear Medicine, 1969, honoring Herrman L. Blumgart, MD.


Augustus Volney Waller (1816-1870). Wallerian degeneration.


Kidney transplants. Are the issues being faced?


Stewart's Hospital is 100.

Stewart's Hospital is 100.


Environmental lead and its paediatric significance.


Protein deficiency disorders.

Protein deficiency disorders.


The management of chronic or recurrent diarrhoea in childhood.


Immunization practice in the United Sttes and Great Britain: a comparative study.


Renal agenesis, oligohydramnios and diabetes mellitus.


The effect of internal mammary artery implantation on myocardial blood flow during temporary coronary occlusion in dogs.


Principles of fluid and electrolyte therapy in pediatric urology.


Bilirubin and red cell metabolism in relation to neonatal jaundice.


Leo Kanner's concept of early infantile autism.


The effect of graft thickness, donor site and graft bed on graft shrinkage in the hooded rat.


Neurovascular island flap in the treatment of trophic ulceration of the heel.


A further use for the neurovascular island flap principle in hand surgery: the piggy-back flap.


The control of recurrent Dupuytren's contracture by skin replacement.


Behaviour of dermal fat transplants.

Behaviour of dermal fat transplants.


Ethyl chloride for grafting the conscious patient.


Inflatable splint: an adjunct to prevention and treatment of cervical scar contractures.


Eric William Peet.

Eric William Peet.


Surgical aspects of clinical renal transplantation.


Early surgery in the treatment of burns.


Effect of monovalent cations on the activity of the DNA polymerase of Escherichia coli B.


The effect of antibiotics on the coded binding of peptidyl-tRNA to the ribosome and on the transfer of the peptidyl residue to puromycin.


Polynucleotide phosphorylase: anomalous viscosity changes observed during the polymerization of nucleoside diphosphates.


Interaction of the RNA polymerase inhibitor chromomycin with DNA.


Continuous cultivation of microorganisms.


Bibliography on cancer (1957-1967). Articles on cancer published in Indian Medical Journals including articles of Indian authors published in foreign journals.


Reactions between anti-nuclear factors and the nuclei of azathioprine-treated subjects.


A critique of abstinence criteria in the treatment of alcoholism.


The genesis of a cancer cell.

The genesis of a cancer cell.


Nobel prize winners in medicine, 1968.

Nobel prize winners in medicine, 1968.


Changes in amniotic fluid volume with advancing pregnancy.


A co-operative double-blind evaluation of gastric "freezing" in the treatment of duodenal ulcer.


Dilemmas of angina pectoris.

Dilemmas of angina pectoris.


Effects of high oxygen pressures on the eye.


Baragwanath Hospital's twenty-first birthday.


Hydrocephalus in African children: a survey of 3 years' experience at Baragwanath Hospital.


Cutting procedures with minimized trauma.


Repair of scleral lacerations with 8-O white virgin-silk sutures.


Quantitative systemic corticosteroid effect on xenograft reaction.


Penetrating keratoplasty in interstitial keratitis.


Correction of minimal blepharoptosis.

Correction of minimal blepharoptosis.


Grafts from living eyes for lamellar keratoplasty.


A corneal punch.

A corneal punch.


Closure of cataract incision with a reinforced conjunctival flap.


Pulmonary edema as a result of endotoxemia.


Relationship of gastric secretion to food intake in lactating rats.


Gastrin-related peptides as stimulants of pancreatic and gastric secretion.


Bela Schick memorial lecture: Allergy--a problem illness.


Sensitivity to Triatoma bite.

Sensitivity to Triatoma bite.


Bronchodilator action of drug combinations in asthmatic patients: decloxizine, orciprenaline, and ephedrine.


Prosthetics in otolaryngology.

Prosthetics in otolaryngology.


Robert Jones, his life and ours to-day.

Robert Jones, his life and ours to-day.


Sir Arthur Sims, Hon. F.R.C.S. (1877-1969).


Organ transplantation for advanced cardiopulmonary disease.


Isotope quantitation of aortic insufficiency compared to cineangiography in man.


Detection of group A streptococci in throat swabs by direct fluorometry. A direct fluorometric test for the rapid detection of group A streptococci from throat swabs was compared with the microscopic fluorescent-antibody test. Formalinized throat swab cultures (490) were examined by the two methods, and the results agreed on 84% of the specimens. In another comparison, 15-hr broth cultures of 103 freshly taken throat swabs were tested by both methods. Of the specimens tested, 101 (98%) were either positive or negative by both methods. In all cases, the latter results correlated with the demonstration of presence or absence of group A streptococci in the specimens by cultural isolation and precipitin grouping tests. It may be feasible to use the direct fluorometric test in a diagnostic laboratory as described or possibly to adapt it for automatic processing of throat swab cultures.


Enhanced recovery of airborne T3 coliphage and Pasteurella pestis bacteriophage by means of a presampling humidification technique. This paper reports a series of experiments in which two methods of collecting airborne bacteriophage particles were compared. A standard aerosol sampler, the AGI-30, was evaluated for its competence in measuring the content of bacteriophage aerosols. It was used alone or with a prewetting or humidification device (humidifier bulb) to recover T(3) coliphage and Pasteurella pestis bacteriophage particles from aerosols maintained at 21 C and varied relative humidity. Collection of bacteriophage particles via the humidifier bulb altered both the initial recovery level and the apparent biological decay. Sampling airborne bacteriophage particles by the AGI-30 alone yielded data that apparently underestimated the maximal number of potentially viable particles within the aerosol, sometimes by as much as 3 logs.


Charles L. Wilbar, Jr., MD.

Charles L. Wilbar, Jr., MD.


Tube dilution antimicrobial susceptibility testing: efficacy of a microtechnique applicable to diagnostic laboratories. A microtechnique for determining antibiotic susceptibilities by the serial dilution method was evaluated in a clinical diagnostic microbiology laboratory. As compared with the standard tube method, an agreement of 94% was achieved for determining minimal inhibitory concentration with +/- one tube dilution as the criterion of comparison. The experience with this system suggests that it could easily be incorporated into diagnostic laboratories as a routine procedure.


The end of an ice age. Ice harvesting as an occupation.


Reverse dermis grafts on bare bone.

Reverse dermis grafts on bare bone.


Temporal bone treponemes.

Temporal bone treponemes.


Bacteriophage typing as an epidemiological tool for urinary Escherichia coli. Phage typing was used to identify strains of Escherichia coli isolated from urinary and nonurinary sources. When eight phages isolated in Pennsylvania were used to type 717 cultures from Missouri, 50.3% of 624 urinary isolates and 34.4% of 93 nonurinary isolates were typable. Strains from nonurinary sources were not found commonly in urine. When five additional phages isolated in Missouri were added to the original set of eight phages, 80.4% of 331 urinary isolates were typable. When this set of phages was used to type 552 urinary cultures isolated in California, Minnesota, Ohio, Pennsylvania, Virginia, and West Virginia, 82.0% of the cultures were typable. Some common phage types were found in high incidence among cultures from the different regions. No correlation was found between phage type and the pattern of resistance to antibiotics. Phage typing data were presented also on the number of strains in individual urine specimens and the recurrences of strains in patients with chronic bacteriuria. Of 97 fecal isolates, 75.2% of the cultures were typable, and the most common phage type was observed in high incidence among the urinary isolates from this region. When 75 cultures from nine other genera of enteric bacteria were typed, only the shigellae were lysed. In view of the information obtained by phage typing and the ease and speed with which it can be done, it is suggested that phage typing be considered a new tool in epidemiological studies of urinary tract infections by E. coli.


Transferable drug resistance among Enterobacteriaceae isolated from human urinary tract infections. Fifteen sulfonamide-resistant cultures isolated from urinary tract infections in eastern Nebraska were screened for transferable drug resistance by three methods. Seven of the 15 resistant cultures could transfer resistance of varying levels to two or more chemotherapeutic agents. Transfer of drug resistance occurred without accompanying transfer of chromosomal traits and required cell to cell contact. In mixed culture, the number of drug-resistant recipients increased exponentially, reaching a plateau 2 hr after mixing. Spontaneous or artificial elimination of resistance was found to be a rare event. In addition, several drug-sensitive isolates from urinary tract infections were shown to be competent recipients of drug resistance determinants. From these data, it appears that the transferable drug resistance observed was mediated by R factors.


Circadian rhythms and their significance to the anaesthetist: a review.


Combination of arabinosyl cytsone, methylglyoxal bis (guanylhydrazone), 6-mercaptopurine and prednisone in the treatment of acute myelocytic leukemia.


The value of the subtraction method in the diagnosis of acoustic neurinomas.


Measurement of renal medullary blood flow.


Effect of hypophysectomy on the oxidative ang glycolytic metabolism of hypothalamus.


The gut and oral glucose tolerance.

The gut and oral glucose tolerance.


Obituary: Thomas Lionel Hardy.

Obituary: Thomas Lionel Hardy.


Electric-potential difference--a neglected parameter of gut integrity and function?


H. L. Alexander (1888-1969).

H. L. Alexander (1888-1969).


Quantitative assay of interferon by the immunofluorescent cell-counting technique.


Further observations on the structure of influenza viruses A and C.


The effect of 5-aminoacridine on the vegetative reproduction of bacteriophage lambda.


Silver plating rubber base material for superior dies and casts.


Minimum clinical procedures for satisfactory complete denture, removable partial denture, and fixed partial denture services.


Cast restorations with gold-foil-like margins.


Boxing alginate impressions.

Boxing alginate impressions.


Casting shrinkage of one-piece-cast fixed partial dentures.


Site- and gene-specific limited heterocatalytic expression in bacteriophage T4-infected Escherichia coli. Genetic evidence for site- and gene-specific variation in limited heterocatalytic expression in phage T4-infected Escherichia coli is reported, and the implications of such variation are discussed.


Phospholipid metabolism in T4 bacteriophage infected Escherichia coli K-12 (lambda). Infection of Escherichia coli K-12 (lambda) by bacteriophage results in an altered labeling pattern of phospholipids in the host cell. Although the overall incorporation of (32)P(i) into phospholipids is decreased by infection, the relative amounts of phosphatidylglycerol and cardiolipin are increased. Phospholipid changes occurring at later stages in the lytic cycle of infected bacteria are more prominent than those at earlier time intervals. The uptake of (32)P(i) into phospholipids of cells infected with T4Bs and endolysin-negative mutants was similar to that observed with the wild-type phage, suggesting that the development of resistance to lysis from without and the repair of mucopeptides are not responsible for the phospholipid changes. The metabolism of phospholipids in uninfected cells treated with cyanide was similar to that of infected cells, indicating that part of the phage-induced alterations may be a consequence of impaired respiration.


Mutant of phi X174 accessible to host-controlled modification. A proflavine-induced phiX174 mutant was isolated, phiX174 sB1, which is accessible to restriction and modification by B-host specificity, but not by K-host specificity.


Principles of frontal reconstruction.

Principles of frontal reconstruction.


Malignant lymphoma of head and neck.

Malignant lymphoma of head and neck.


Combined technique of otoplasty.

Combined technique of otoplasty.


Post-natal development of rat pituitary melanocyte-stimulating hormone and the effect of light.


Interaction between Clostridium botulinum type E toxin and DDT in white mice.


Further experience with the use of percutaneous suprapubic aspiration of the urinary bladder. Bacteriologic studies in 654 infants and children.


Natural history of "apparently healed" acute poststreptococcal glomerulonephritis in children.


Current bibliography on allergy and applied immunology.


The surgical treatment of parkinson's disease: cryothalamectomy.


The pregnant Natal Indian diabetic.

The pregnant Natal Indian diabetic.


Wm. Niles Wishard, Sr.: urologist, educator, administrator, medical statesman, church and family man.


Respirator treatment of crushed chest injuries.


The elderly comment on medicare.

The elderly comment on medicare.


Hypospray treatment of tennis elbow.

Hypospray treatment of tennis elbow.


Human middle ear epithelium. An ultrastructural and cytochemical study.


Surgical repair of dural herniation into the mastoid bowl.


Suture technique of otoplasty.

Suture technique of otoplasty.


Two-stage designs for clinical trials.

Two-stage designs for clinical trials.


Coenzyme analog inhibitors of apoglutamate decarboxylase.


Metabolism of progesterone-4-14C in vitro in human skin and vaginal mucosa.


Saturation of dark repair synthesis: accumulation of strand breaks. Reversal of ultraviolet light damage to DNA by the dark repair system is limited. Experiments utilizing density and radioactive labels demonstrated that repair synthesis is not proportional to dose at doses above 200 ergs/mm(2). In addition, the number of residual excision induced gaps in Escherichia coli B/r hcr(+) DNA increases with higher UV doses. The extent of repair is apparently limited by saturation of the repair synthesis step.


Edentulous may mean more than no teeth.

Edentulous may mean more than no teeth.


Correlation of a simplified method for the calculation of areas under indicator-dilution curves.


Current status of the chemical structure of bovine pancreatic carboxypeptidase A.


Changes in electrical activity in the rat hypothalamus related to electrochemical stimulation of adenohypophyseal function.


Lithium carbonate (a review).

Lithium carbonate (a review).


Ovarian ascorbic acid depleting factors in the chicken hypothalamus.


Pseudomosaicism in acatalasemic red cells visualized by fluorescent antibody technic.


Metabolism of progesterone by the rabbit mammary gland.


Phage-enhanced suppression of the growth of revertants by auxotrophs in Salmonella typhimurium.


Changes in the treatment of involutional melancholia.


Enzymes of tryptophan biosynthesis in Serratia marcescens. In Serratia marcescens, the tryptophan biosynthetic enzymes were formed coordinately. A number of tryptophan auxotrophs showed single biochemical lesions; several mutants showed pleiotropic effects. Sucrose density gradient centrifugation revealed an unique pattern of migration of the tryptophan biosynthetic enzymes. The repression response of the Serratia enzymes to exogenous tryptophan was fivefold more sensitive than that found in Escherichia coli. When this information is contrasted with the available information on the other Enterobacteriaceae, one is compelled to conclude that S. marcescens enjoys a rather marked evolutionary divergence from the other enteric organisms.


Phenotypic suppression in Escherichia coli by chloramphenicol and other reversible inhibitors of the ribosome. Antibiotics that interfere reversibly with various aspects of ribosomal function (chloramphenicol, tetracycline, erythromycin, and spectinomycin) are shown to antagonize, at barely inhibitory concentrations, the inhibitory effect of low concentrations of streptomycin (SM) on the growth of Escherichia coli. Paradoxically, these compounds can also replace SM in supporting the growth of conditionally SM-dependent mutants. Chloramphenicol produced about as much phenotypic suppression as SM in SM-sensitive strains, but less than that attainable with high concentrations of SM in resistant strains. The antagonism to SM inhibition and the phenotypic suppression appear to be specific for those growth inhibitors that act on the ribosome. Since inhibitors of the 50S subunit of the ribosome (chloramphenicol, erythromycin) are as active as inhibitors of the 30S subunit, it is suggested that phenotypic suppression by borderline concentrations of ribosome inhibitors does not necessarily depend on an alteration of the recognition region of the ribosome. Alternatively, partial inhibition of the ribosomes might change the environment in a way that would influence the frequency of misreading. Phenotypic suppression by a low concentration of SM as well as by chloramphenicol was found to depend on the presence of a trace of the required growth factor.


Purification, ultrastructure, and composition of axial filaments from Leptospira. The ultrastructure of three strains of water Leptospira was studied by negative staining, thin sectioning, and freeze-etching. The cells possessed a triple-layered sheath which covered two independent axial filaments, one inserted subterminally in each end of the cell. The protoplasmic cylinder was surrounded by a triple-layered cell wall and possessed ribosomes, lamellar structures, and a typical procaryotic nuclear region. The axial filament was comprised of several component structures. An axial fibril, with a diameter of 20 to 25 nm, consisted of a solid inner core (13 to 16 nm in diameter) surrounded by a coat. A terminal knob (40 to 70 nm in length) was connected to a series of disc insertion structures at the terminal end of the axial fibril. The axial fibril was surrounded by a helical outer coat (35 to 60 nm in diameter) which was composed of a continuously coiled fiber, 3 to 4 nm in diameter, embedded in an electron-dense material. A procedure for the purification of the axial fibrils was presented and their ultrastructural, physical, and chemical properties were determined. Similarities in ultrastructural, physical, and chemical properties were noted between the axial fibrils and bacterial flagella. A schematic model of the leptospiral axial filament is presented, and a mechanism is proposed for its function as a locomotor organelle.


New hemolysin (gamma) produced by Escherichia coli. A new hemolysin (gamma) of Escherichia coli, active in the absence of viable bacteria, has been recognized in mutants resistant to nalidixic acid. Nalidixic acid affects either the production or release of the hemolysin.


Locus determining P1 phage restriction in Escherichia coli. The locus determining P1 phage restriction has been mapped at 89.3 min on the Escherichia coli map, about 0.2 min away from the hsp marker.


Analgesic nephrotoxicity.

Analgesic nephrotoxicity.


Value and limitations of quantitative chemical studies in individual cells.


The variation of urinary oxalate excretion with age.


Educating patients to accept dentures.

Educating patients to accept dentures.


Oral lesions caused by ill-fitting dentures.


Centrifugal casting process for resin-base dentures.


Water temperature and accuracy of alginate impressions.


Fabrication of ear prosthesis.

Fabrication of ear prosthesis.


A comparative study of two antihistamines.


Opipramol and trifluoperazine in the treatment of anxiety and tension.


Effects of Halidor on soft oral structures.


Rapid bioassay for Clostridium botulinum type-E toxins by intravenous injection into mice.


Study of some factors contributing to aerosol production by the air-turbine handpiece.


Cross-reactivity of human and rat cariogenic streptococci in dentin.


Lord Moran and James Boswell: the two diarists compared and contrasted.


Electrical stimulation of sensory nerves with skin electrodes for research, diagnosis, communication and behavioral conditioning: a survey.


A royal medicine chest.

A royal medicine chest.


Rifampicin sensitivity of the components of DNA-dependent RNA polymerase.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-1969.


Evaluation of cardiac transplantation.

Evaluation of cardiac transplantation.


Positive-pressure breathing and antidiuresis.


Menarche and pubarche.

Menarche and pubarche.


Bach, Handel, and "Chevalier" John Taylor, M.D., ophthalmiater.


Smallpox--and Lady Mary.

Smallpox--and Lady Mary.


Transplantation. 4. Other tissues and organs.


Walter Joseph Meek, 1878-1963.

Walter Joseph Meek, 1878-1963.


An evaluation of English diets of the 1860's.


Digestion of protein in the intestines of adult ruminants.


Carbohydrate metabolism in the foetus and the newly born.


A re-evaluation of the concept of cocarciongenesis.


Theory and practice of intensive residential treatment of adolescents.


On Mark Twain. "Never quite sane in the night".


Semantics of the placebo.

Semantics of the placebo.


Precognition--or telepathy from the past?


Nandor Fodor: analyst of the unexplained.


Cytophaga that kills or lyses algae.

Cytophaga that kills or lyses algae. A myxobacterium (Cytophaga N-5) isolated from sewage kills or lyses an array of living green and blue-green algae. When assayed with Nostoc muscorum or Plectonema boryanum, plaques form like those caused by the blue-green algal virus LPP-1. This isolate lyses or inhibits mutually Gram-positive and Gram-negative eubacteria.


Compere irrigation-suction method in orthopedic infections.


Superficial pyodermas and acute glomerulonephritis.


The drug response of a normal and a multi-resistant strain of P. falciparum to sulphalene.


Amoebiasis: clinical trials of dehydroemetine late-release tablets (Ro 1-9334-20) compared with parenteral dehydroemetine and niridazole.


Pathological findings in hydrops foetalis due to alpha-thalassamemia: a review of 32 cases.


On the life cycle of trypanosomes of the lewisi group and their relationships to other mammalian trypanosomes.


Leptospirosis. II. Serology.

Leptospirosis. II. Serology.


Folic acid coenzymes in the biosynthesis of purines and pyrimidines.


Effect of diphenidol and prochlorperazine on semicircular canal function in man.


Treatment of influenza. The therapeutic efficacy of rimantadine HC1 in a naturally occurring influenza A2 outbreak.


Alterations in chromosomes and DNA content in gynecologic neoplasms.


Optical properties of buried corneal silicone prostheses.


Trabeculectomy. Preliminary report of a new method.


Intracapsular extraction of congenital cataract. Technique in two successive stages.


Von Hippel-Lindau disease. Histopathologic findings in a treated and an untreated eye.


Corneoscleral suture loop retrieval without instrumentation.


Conjunctival closure in strabismus surgery.


Lowering of plasma iron concentration in the rat with leukocytic extracts.


Effect of diazepam on awareness during caesarean section under general anaesthesia. The use of diazepam for premedication before elective caesarean section increased the incidence of unpleasant recall postoperatively, compared with atropine in a previous study. This finding suggests that diazepam is unsuitable for this type of anaesthesia.


Cadaveric kidneys for transplantation.

Cadaveric kidneys for transplantation.


Production of a cholinesterase-solubilizing factor from a Cytophaga sp. by continuous cultivation.


Prodigiosin and the metabolism of free amino compounds in Serratia marcescens as a function of iron, manganese, and aging.


Soil bacteria: comparisons of rhizosphere and nonrhizosphere populations.


Quantitative comparative immunohistology.


The potentiating effect of rheumatoid arthritis serum in the immediate phase of nephrotoxic nephritis.


Antigens in thymus and muscle effective in inducing experimental autoimmune thymitis and the release of thymin.


Cell differentiation and pseudodifferentiation in in vitro cultures of spleen.


Prediction of psychopharmacologic effect in man: development and validation of a computerized diagnostic decision tree.


Are chloroplasts polyploid?

Are chloroplasts polyploid?


Innervation of the chamber angle of the guinea pig eye.


Synthesis of lens protein in vitro. IV. Further characterization of the lens cell-free system.


Further characterization of the lens cell-free system.


Observations on the posterior membrane of the corneal endothelium.


Sutureless surgery--a promise from polymers.


An organophosphorus round-up. II.

An organophosphorus round-up. II.


Some progress on beryllium.

Some progress on beryllium.


The genetic properties of DNA transferred from ultraviolet-irradiated Hfr cells of Escherichia coli K-12 during mating.


Duplication of a gene belonging to an arginine operon of Escherichia coli K-12.


Suppressors causing temperature sensitivity of growth in Escherichia coli.


Structural studies of immunoglobulins. 3. Susceptibility of human gamma G globulins to peptic hydrolysis and papain sensitivity of F(ab')2 fragments.


Antigenicity of histones: comparative studies on histones with very high lysine content from various sources.


The intracellular localization of Castle's intrinsic factor by an immunofluorescent technique using autoantibodies.


Developments in liquid scintillation counting since 1963.


Errors in measurement of cardiac output with dye-dilution curves in shock.


Relation of occlusion to temporomandibular joint dysfunction: the prosthodontic viewpoint.


Effect of hematocrit on response characteristics in indocyanine green densitometers.


Comparison of two methods of measuring pulmonary capillary blood flow in dogs.


Effect of flow on transpulmonary circulatory transport functions.


The ultrastructure of the cat myocardium. I. Ventricular papillary muscle. The ultrastructure of cat papillary muscle was studied with respect to the organization of the contractile material, the structure of the organelles, and the cell junctions. The morphological changes during prolonged work in vitro and some effects of fixation were assessed. The myofilaments are associated in a single coherent bundle extending throughout the fiber cross-section. The absence of discrete "myofibrils" in well preserved cardiac muscle is emphasized. The abundant mitochondria confined in clefts among the myofilaments often have slender prolongations, possibly related to changes in their number or their distribution as energy sources within the contractile mass. The large T tubules that penetrate ventricular cardiac muscle fibers at successive I bands are arranged in rows and are lined with a layer of protein-polysaccharide. Longitudinal connections between T tubules are common. The simple plexiform sarcoplasmic reticulum is continuous across the Z lines, and no circumferential "Z tubules" were identified. Specialized contacts between the reticulum and the sarcolemma are established on the T tubules and the cell periphery via subsarcolemmal saccules or cisterns. At cell junctions, a 20 A gap can be demonstrated between the apposed membranes in those areas commonly interpreted as sites of membrane fusion. In papillary muscles worked in vitro without added substrate, there is a marked depletion of both glycogen and lipid. No morphological evidence for preferential use of glycogen was found.


Nuclear shape in muscle cells.

Nuclear shape in muscle cells.


Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver. The basic morphological properties of liver cells are defined in the form of a morphometric model to permit integrated quantitative characterization of functionally important parameters. Stereologic methods which allow efficient and reliable quantitative evaluation of sectioned liver tissue are presented. Material, obtained by a rigorous three-stage sampling procedure from five normal rat livers, is systematically subjected to this analysis at four levels of magnification. This yields quantitative data which are expressed as "densities," i.e. content per 1 ml of tissue, as "specific dimensions" related to 100 g body weight, and as absolute dimensions per average "mononuclear" hepatocyte. Base line data relating to the normal rat liver are presented for the entire spectrum of parameters. As examples, 1 ml of liver tissue contains 169 x 10(6) hepatocyte nuclei, some 90 x 10(6) nuclei of other cells, and 280 x 10(9) mitochondria. Hepatocyte cytoplasm accounts for 77% of liver volume, and the mitochondria for 18%. The surface area of endoplasmic reticulum membranes in 1 ml of liver tissue measures 11 m(2) of which are (2/3) of the rough form carrying some 2 x 10(13) ribosomes. The surface area of mitochondrial cristae in the unit volume is estimated at 6 m(2). The validity and applicability of the method are discussed, and the data are compared with available information from other studies.


Influence of mutagenic agents on the integration of the F episome into the chromosome of Escherichia coli K12F+.


Osmotic fragility of bacteria deprived of carbon dioxide.


The effect of glutamate on toxin production by Clostridium tetani.


Ganglioside as a prophylactic agent in experimental tetanus in mice.


The aerosol survival and cause of death of Escherichia coli K12.


The detection of a strain of Chromobacterium lividum in the tissues of certain leaf-nodulated plants by the immunofluorescence technique.


Viable counts of bacteria--a new method for facultative anaerobes.


Conditional probability and the identification of bacteria: a pilot study.


A new type of micromanipulator and microforge.


Toxicity of spores of Clostridium botulinum strain 33A in irradiated ground beef.


History of the motor theories of attention.


Ultraviolet induction of chromosome transfer by autonomous sex factors in Escherichia coli.


Quantitative analyses of psychoanalytic studies of Shakespeare.


Charles Nicolle (1866-1936), bacteriologist.


Sponttaneous rupture of the distal thoracic oesophagus.


Propranolol in angina pectoris.

Propranolol in angina pectoris.


C.N.S. malformations in South Wales.

C.N.S. malformations in South Wales.


Induction of labour by amniotomy and oxytocin infusion.


Scleroderma. 2. Incidence of systemic disturbance and assessment of possible aetiological factors.


Lomotil.

Lomotil.


The specificity of drug receptors. An immunochemical model for cholinergic receptors.


The structural features determining the affinity of haptens for an antibody binding acetylcholine.


Interchangeability of ribosomes and protein synthesizing enzymes from Penicillium cyclopium and those prepared from other organisms.


DNA strand breakage in cells irradiated with x-rays.


Identification of human trophoblast in vitro.


Chemical components in the cell wall of Salmonella typhimurium affecting its virulence and immunogenicity in mice.


The influence of phenoxybenzamine (dibenzyline) on the pulmonary veins of intact anesthetized dogs.


Comparison of bacteriolysis, passive hemolysis, and bacterial adherence colony formation for detecting antibody-forming cells.


Effect of trauma and infection on lyozyme in poultry tissue.


Studies on early-appearing interferon in vitro. Production of endotoxin-induced interferon by mouse spleen cells cultured in vitro.


Extended production of insulin by isolated rabbit pancreatic islets; evidence for biosynthesis of insulin.


Persistence of group A streptococci labeled with fluorescein isothiocyanate in inflammatory sites in the heart and muscle of mice and rabbits.


Suppression of antibody synthesis by chloramphenicol analogs.


Effects of thyroxine and thiouracil on hypothalamic PIF and pituitary prolactin levels.


Antibacterial compound from a soybean product fermented by Rhizopus oligosporus.


The detection of transplantation antigens in leukocytes.


Prevention and therapy of thromboembolic complications with dextran.


Progress in liver transplantation.

Progress in liver transplantation.


Stapling devices and their use in surgery.


Biosynthesis of oligosaccharides and polysaccharides in plants.


Marihuana effects amid great expectations.


Intermediates in T4 DNA replication in a T4 ligase deficient strain.


Initiation of the replication of single-stranded DNA by Escherichia coli DNA polymerase.


Studies on the joining of DNA by polynucleotide ligase of phage T4.


Repair replication of DNA in vivo.

Repair replication of DNA in vivo.


Enzymatic mechanisms of the repair and breakage of DNA.


DNA replication and recombination after UV irradiation.


Nucleases specific for ultraviolet light-irradiated DNA and their possible role in dark repair.


Recovery of recombination deficient mutants of Escherichia coli K-12 from ultraviolet irradiation.


Effect of 32P-decay on chromosome transfer by a radiation-sensitive Hfr strain of Escherichia coli.


Breakage of DNA in rec+ and Rec- bacteria by disintegration of radiophosphorus atoms in DNA and possible cause of pleiotropic effects of RecA mutation.


Enzymatic DNA degradation in E. coli: its relationship to synthetic processes at the chromosome level.


Endonuclease II of E. coli.

Endonuclease II of E. coli.


Studies with DNA-cellulose chromatography. I. DNA-binding proteins from Escherichia coli.


DNA synthesis in temperature sensitive mutants of Escherichia coli.


Repair and recombination in phage T4. I. Genes affecting recombination.


Repair and recombination in phage T4. II. Genes affecting UV sensitivity.


The function of T4 DNA polymerase.

The function of T4 DNA polymerase.


Evidence for a possible direct role of dCMP hydroxymethylase in T4 phage DNA synthesis.


Replication and recombination of DNA fragments in bacteriophage T4.


Phage DNA synthesis in bacteria infected with T4 light particles.


Proflavin treatment of Escherichia coli: generation of frameshift mutations.


DNA replication: physical factors.

DNA replication: physical factors.


Cyclization of phage DNAs.

Cyclization of phage DNAs.


The intracellular forms of T7 and P22 DNA molecules.


Studies with Escherichia coli sex factors.


Complex mitochondrial DNA.

Complex mitochondrial DNA.


Stages in the replication of bacteriophage phi X174 DNA in vivo.


Molecular recombination in a circular genome-phi X174 and S13.


Regulation of the propagation of HR virus plasmid.


DNA replication: the rolling circle model.


DNA polymerase and the cell membrane after T4 infection.


Initiation and propagation of growing points in the DNA of phage T4.


The structure of replicative lambda DNA--electron microscope studies.


Replication of phage lambda DNA.

Replication of phage lambda DNA.


Periodic replication of DNA in steadily growing Escherichia coli: the localized origin of replication.


On the origin and direction of replication of the E. coli chromosome.


Chromosome replication in some strains of Escherichia coli K12.


The replication of the Escherichia coli chromosome studied by sequential nitrosoguanidine mutagenesis.


Growth direction and segregation of the E. coli chromosome.


The starting point and direction of lambda DNA replication.


A preferred origin for the replication of lambda DNA.


Nalidixic acid inhibition of DNA transfer in Escherichia coli K12.


The properties of DNA transferred to minicells during conjugation.


Strand selection during bacterial mating.


Asymmetric transfer of DNA strands in bacterial conjugation.


Intermediates in the synthesis of phage P22 DNA.


Shear sensitivity of the E. coli genome: multiple membrane attachment points of the E. coli DNA.


Thermosensitive mutants of E. coli affected in the processes of DNA synthesis and cellular division.


Structure and function of DNA cohesive ends.


Active and inactive states of the CI gene in some lambda defective phages.


Lambda dv: an autonomously replicating DNA fragment.


Prophage P1, and extrachromosomal replication unit.


On the bacterial life sequence.

On the bacterial life sequence.


The regulation of DNA replication and cell division in E. coli B-r.


In vitro synthesis of phage RNA: the nature of the intermediates.


Metabolism and growth of gene substance: 1968.


A selected public health bibliography with annotations.


HO-HO-HO Sect.

HO-HO-HO Sect.


Clinical studies of the interaction between d-tubocurarine and succinylcholine.


Pathogenesis of the pulmonary changes following ischemia of the lower extremities.


The effect of pH on the kinetic constants of peptic substrates and inhibitors.


The amino acid sequence of bovine liver catalase: a preliminary report.


Proposed formula for ventilatory requirements in apneic anesthetized patients.


Bone marrow as source of cells in reactions of cellular hypersensitivity. 3. Adjuvant arthritis in the rat.


The structure of a feline picornavirus and its relevance to cubic viruses in general.


Murine amyloid. II. Transfer of an amyloid-accelerating substance.


In memoriam Edward F. Hartung, M.D., 1899-1969.


Control of glutamate dehydrogenase synthesis in Escherichia coli.


DEAE-cellulose fabric for selective adsorption of different species of cells.


Effect of phosphate, arsenate and ATP on chloramphenicol acetylation by cell-free extracts of Escherichia coli B.


Polycythemia rubra vera with pernicious anemia. Some observations on vitamin B 12 metabolism.


Keats memorial lectures.

Keats memorial lectures.


Studies on red cell aplasia. II. Report of a second patient with an antibody to erythroblast nuclei and a remission after immunosuppressive therapy.


Liver transplantation in man--IV, Haemorrhage and thrombosis. Blood coagulation and fibrinolytic factors have been measured in 13 patients treated by liver transplantation. During operation intravascular coagulation and fibrinolysis were increased, but seldom to a degree which would cause abnormal bleeding. Measurement of the catabolism of radioactive fibrinogen showed that increased intravascular coagulation continued for long periods after the operation. Despite secondarily increased fibrinolysis, there was a high incidence of thrombosis. Treatment with anticoagulants or with fibrinolysis inhibitors may be valuable in these patients.


Nitrazepam--a safe hypnotic.

Nitrazepam--a safe hypnotic. In 27 patients nitrazepam (Mogadon) taken in acute overdosage produced no untoward effects except drowsiness, even when 80 tablets were consumed. A double-blind trial in patients in general medical wards established that nitrazepam was as effective as butobarbitone as a hypnotic. It is concluded that nitrazepam is a safe and effective hypnotic.


Bronchial lavage in status asthmaticus.

Bronchial lavage in status asthmaticus.


Drug treatment of thyrotoxicosis.

Drug treatment of thyrotoxicosis.


Keats--the man, medicine and poetry.

Keats--the man, medicine and poetry.


Pathology of the conduction system in cardiac rejection.


Anti-adrenal, cellular hypersensitivity in Addison's disease.


The further characterization of autoantibodies reactive with extra-adrenal steroid-producing cells in patients with adrenal disorders.


The application of microphotometry to the indirect immunofluorescent antibody technique using the human gastric parietal cell antigen-antibody system.


Antibody to the oxyphil cells of the human parathyroid in idiopathic hypoparathyroidism.


The treatment of carcinoma of the hypopharynx: the gutter-graft operation.


Needle biopsy of skeletal muscle: a phase and electron microscopic evaluation of its usefulness in the study of muscle dsease.


Automated techniques in pharmaceutical analysis.


William Charles Wells (1757-1817) South Carolinian Tory.


Some higher functional correlates of the transcephalic D. C. circuit.


Psychopharmacology: an overview.

Psychopharmacology: an overview.


Watchers upon the east. The ocular complaints of Emily Dickinson.


Divided allegiance.

Divided allegiance.


Mitochondrial DNA: advances, problems, and goals.


Ion exchange in Escherichia coli: potassium-binding proteins.


Ribosomal protein conferring sensitivity to the antibiotic spectinomycin in Escherichia coli.


Delayed hypersensitivity reactions in the intestinal tract. 3. Pig stomach gastritis and parietal cell antibodies.


Correlative study of hydrochloric acid, pepsin, and intrinsic factor secretion in newborns and infants.


Ascertainment of mortality in the U. S. veteran population.


Lung tissue shrinkage for histologic preparations.


The Pollock appliance.

The Pollock appliance.


Steatorrhea associated with disordered bile acid metabolism. Micellar phase defects.


Effects of formaldehyde on the pulmonary artery of the dog.


Fixation of the lung for emphysema.

Fixation of the lung for emphysema.


Functional characteristics of the transplanted kidney.


The use of thermography in determining viability of pedicle flaps.


Joseph Madison Greer, M. D. 1887-1969.

Joseph Madison Greer, M. D. 1887-1969.


Medicare administrative alternatives, prospects and trends.


Simple plastic tissue culture chambers for detailed microscopy.


An indicator method for the detection of bacterial X and V factor dependence.


Ribosome degradation in ultraviolet light-damaged bacteria starved for an amino acid.


The combined effects of bleomycin and sulfhydryl compounds on the thermal denaturation of DNA.


Polyamines and protein synthesis. II. The shift in optimal concentration of Mg2+ by polyamines in the MS2 phage RNA-directed polypeptide synthesis.


Comments on "thymineless death induced by cytosine arabinoside".


On the association of basic proteins with RNA in ribosomes and artificial complexes.


Protection of the acceptor sequence CpCpA of tRNA against adenylate (cytidylate) pyrophosphorylase action by acylation of the 2'(3') hydroxyl group of the terminal adenylic acid.


Structural requirements of inhibition of polyphenylalanine synthesis by aminoacyl and nucleotidyl analogues of puromycin.


Clinical trial of clomocycline (Megaclor) in gonococcal and non-gonococcal urethritis.


Studies on the quantitation of intraocular Treponema pallidum. An in vitro model.


Controlled trial of methacycline and tetracycline in the treatment of non-specific urethritis.


Further studies of the morphology of Treponema pallidum under the electron microscope.


S-Adenosylethionine as an inhibitor of tRNA methylation.


An unusual anatomo-pathologic aspects of a case with pseudoxanthoma elasticum.


The effect of nucleosides on the induced synthesis of beta-galactosidase in non-growing cells of Escherichia coli.


Application of the oxidation-reduction potential indicators for characterization of Agrobacterium and Rhizobium species.


Antimicrobial agents. II. Microbial degradation of nalidixic acid.


Glossolalia: a contemporary mystical experience.


Thrombocyte specific antigens. Detection of organ specific antigens by heterospecific anti-thrombocyte serum.


Psychedelic drugs and mystical experience.


The scrupulosity syndrome.

The scrupulosity syndrome.


Psychological dynamics of religion.

Psychological dynamics of religion.


The mental health of ministers' wives and families.


The mental health of members of religious communities.


Evaluating candidates for religious service.


Psychotherapy of religious conflict.

Psychotherapy of religious conflict.


The role of clergymen in community mental health programs.


The role of the chaplain in mental hospitals.


Psychiatric consultation to clergymen.

Psychiatric consultation to clergymen.


A contemporary bibliography on psychiatry and religion.


A psychoanalytic view of religion.

A psychoanalytic view of religion.


Pathological processes in religion.

Pathological processes in religion.


The role of religion in psychotherapy.

The role of religion in psychotherapy.


A computer program for tabulation and evaluation of osteopathic findings on hospital patients.


Concepts of autism: a review of research.


Trauma and cancer: a survey of recent literature.


Averroes' view of the retina--a reappraisal.


The effect of dimethyl sulfoxide on rat skin oxygen utilization.


The future of transplantation surgery.

The future of transplantation surgery.


Technique for cross sectioning hair specimens.


Spontaneous peripelvic extravasation during intravenous urography.


Karl Edward Zener: a memoir.

Karl Edward Zener: a memoir.


Experimental temperature control of radiofrequency brain lesion size.


The Schilling test.

The Schilling test.


John Braxton Hicks (1823-1897).

John Braxton Hicks (1823-1897).


Enteric-coated microspherules. A clinical appraisal of two forms of aspirin.


Human kidney transplantation: present status and projected future.


Public health and the conquest of disease in Baltimore, 1792-1968.


The unwanted pregnancy.

The unwanted pregnancy.


Paper fabricated vascular prostheses: influence of wall thickness, compounding, and coating upon healing.


Margaret S. Rood, Sixth Mary McMillan lecturer.


Control of movement patterns in animals.


External levator resection for blepharoptosis.


Lamellar undermining, diathermy, and tissue transplantation versus cryotherapy and full thickness scleral buckling.


How to "handle" secondary impression trays.


Full denture and immediate denture impression trays"..."a precision instrument, anatomically designed".


Reciprocal impressions as an aid to tooth position in complete lower denture prosthesis.


The construction of a phantom head for teaching the clinical stages of impression techniques.


1969 membership directory of the Georgia Dental Association.


Stabilized denture baseplates.

Stabilized denture baseplates.


The role the National Dental Association should pursue relative to federally funded dental programs.


Prosthodontics today.

Prosthodontics today.


Members of the Virginia State Dental Association (as of June 1, 1969).


Multiple myomectomy.

Multiple myomectomy.


Relationship between the oral contraceptive and folic acid metabolism. Serum folate concentrations.


Qualitative thin-layer chromatography of some irritants.


Pesticide residues.

Pesticide residues.


Alcohol and liver disease.

Alcohol and liver disease.


Air pollution.

Air pollution.


Food.

Food.


Metastatic melanoma in the small bowel.

Metastatic melanoma in the small bowel.


Rupture of the duodenum produced by a safety belt.


An experimental preparation suitable for studying the effect of bacterial contamination and infection upon the healing of colon wounds.


Myocarditis and phaeochromocytomata.

Myocarditis and phaeochromocytomata.


The influence of human serum on the anti-tumour activity of two L-asparaginases.


Sir Henry Dale--1875-1968.

Sir Henry Dale--1875-1968.


Digitalis toxicity: a review.

Digitalis toxicity: a review.


Respository drugs. IV. 4',4'''-Sulfonylbisacetanilide (Acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and antileprotic action.


The fibrinolytic system in arteriosclerosis.


Nitroheterocyclic antimicrobial agents. I. Nitrothiazolecarboxaldehyde derivatives.


Antimalarial and antischistosomal agents. N,N"-[sulfonylbis(p-phenyleneazo-1,4-naphthylene)]bis(N',N'-dialkylalkylenediamines).


Synthetic penicillins derived from benznorcaradienecarboxylic acids.


A nonmutagenic thymidine analog with antiviral activity. 5-Ethyldeoxyuridine.


Factors affecting the growth of trophoblast transplanted to the testis.


The intrarenal vascular distribution in the human kidney.


A flap technique for repair of vesicovaginal fistula.


Sir John Floyer (1649-1734) and the discovery of pulmonary emphysema.


The I-131 hippuran renogram in advanced renal disease and renal failure.


Turnover and oxidation of plasma glucose in lean and obese humans.


Persistent estrus: an experimental model of the polycystic ovary syndrome.


Management of premature rupture of the fetal membranes.


The total environment of mining.

The total environment of mining.


Mucus transport in transplanted lungs of dogs.


Hepatic preservation with chlorpromazine and phenoxybenzamine; application to liver transplantation.


Induction of glomerulonephritis in renal autografts.


Mechanisms of leukocyte infiltration of allografts. I. The separation and early appearance of two components.


Intravascular coagulation, hyperlipemia, and fat embolism: their association during the generalized Shwartzman phenomenon in rabbits.


Preparation and in vitro assay of effective and ineffective antilymphocyte sera.


Skin allografts and immunosuppression in the treatment of massive thermal injury.


Postoperative wound infection: a prospective study of determinant factors and prevention.


Intrathecal gentamicin in the treatment of ventriculitis.


The British BCG control centre.

The British BCG control centre.


A four-year follow-up of patients with quiescent pulmonary tuberculosis at the end of a year of chemotherapy with twice-weekly isoniazid plus streptomycin or daily isoniazid plus pas.


A controlled comparison of four regimens of streptomycin plus pyrazinamide in the retreatment of pulmonary tuberculosis.


Virulence of Shigella strains isolated from dysenteric patients and symptomless carriers.


Reliability of exfoliative cytology in induced carcinoma in hamster's pouch.


Primary osteoplasty in patients with clefts of lip, alveolus and palate.


A successful case of basilar bifurcation aneurysm surgery.


Bone grafts in clefted maxilla.

Bone grafts in clefted maxilla.


Epidemiology of ischaemic heart disease.


A dynamic pathology of arterosclerosis.

A dynamic pathology of arterosclerosis.


The sterol hypothesis in atherogenesis.

The sterol hypothesis in atherogenesis.


Blood lipids and lipoproteins in atherogenesis.


Prevention of coronary heart disease and other complications of arteriosclerosis by modified diet.


Hypertension and atherosclerosis.

Hypertension and atherosclerosis.


Atherosclerotic cerebrovascular disease--its nature and management.


Electro-aerosols, air ions and physical medicine.


Hirsutism.

Hirsutism.


The pioneering role of the early clinicians.


A regulatory mutation in tyrosine biosynthesis.


Modification of the lethal and mutagenic effects of high pressure oxygen on Escherichia coli by treatment after exposure.


Management of severe chest injuries.

Management of severe chest injuries.


Immunohistochemical evidence for the transport of dopamine-B-hydroxylase and a catecholamine binding protein in sympathetic nerves.


Treatment of acute exacerbations of chronic bronchitis in general practice.


A new local treatment for haemorrhoids. A general practitioner clinical trial.


Clinical evaluation of clidinium and "libraxin" in the management of duodenal ulcer.


Nortriptyline in the treatment of chronic urticaria.


Pathogenesis of rheumatic fever.

Pathogenesis of rheumatic fever.


Presentation of the Julius Friedenwald Medal to Franz J. Ingelfinger.


Further studies of in vitro cytotoxicity of lymphocytes for colonic epithelial cells.


Upper gastrointestinal bleeding with special reference to peptic ulcer.


Cross section of dermatology through the evolution of history.


Legal answers to heart transplant problems.


Retinoblastoma, a review and some new aspects.


Studies of the bladder defense mechanism. II. Postoperative cystitis in the elderly.


Unique protein moieties for 30S and 50S ribosomes of Escherichia coli. Each major component of the proteins of 30S ribosomes from Escherichia coli was compared with the proteins of 50S ribosomes. The comparisons were done by using polyacrylamide gel electrophoresis in urea with differentially labeled proteins. The data show that no major protein is common to both ribosomes.


Regulation of glyoxylate metabolism in Escherichia coli K-12. The relative contributions of the dicarboxylic acid and the tricarboxylic acid cycles to the oxidative catabolism of glyoxylate in Escherichia coli K-12 were deduced by analysis of mutant strains that were blocked in the formation of glyoxylate carboligase and of malate synthase G (the "glycolate form" of malate synthase). Mutant strains unable to form malate synthase G were unimpaired in their ability to oxidize glyoxylate. Hence, the dicarboxylic acid cycle does not appear to play an essential role in this process. Organisms blocked in the synthesis of glyoxylate carboligase did not oxidize glyoxylate at a detectable rate, indicating that wild-type organisms convert glyoxylate to acetyl-coenzyme A and oxidize it via the tricarboxylic acid cycle. The foregoing evidence indicates that malate synthase G plays an anaplerotic role during growth with glycolate or acetate as the carbon source. The in vivo activity of malate synthase G was not detectable when the intracellular concentration of acetyl-coenzyme A was low, suggesting that this substrate or a closely related metabolite exerts a sensitive positive control over the enzyme. The synthesis of malate synthase G appears to be induced directly by glycolate which may be formed by a constitutive reduced nicotinamide adenine dinucleotide phosphate-dependent glyoxylate reductase in glyoxylate- or acetate-grown cells.


Iron transport in Escherichia coli: relationship between chromium sensitivity and high iron requirement in mutants of Escherichia coli. Utilization of iron (Fe(3+)) by Escherichia coli depends upon a system which is determined by at least two genetic loci. Mutants which carry a deletion of the tonB-trp region of the chromosome grow only when very high concentrations of iron are present in the medium. These strains are sensitive to chromic ion (Cr(3+)) and, unlike the parent strain, fail to grow on MnSO(4) when FeSO(4) is not added to the medium. A second type of mutant, Chr2, which was isolated on the basis of its sensitivity to chromic ion, also requires a high concentration of iron for growth. This mutant can be distinguished phenotypically from the deletion mutants since it grows normally on low concentrations of iron, provided citrate is added to the medium. The chromium sensitivity of both types of mutants can be reversed by high concentrations of exogenous iron. The data are interpreted to indicate that the E. coli mutants studied are defective in iron transport and that residual iron transport is in some way inhibited by chromic ion.


Iron transport in Escherichia coli: roles of energy-dependent uptake and 2,3-dihydroxybenzoylserine. Escherichia coli strains B/r and 2276 contain an active transport system for iron. The system is energy-dependent, repressed by excess iron in the growth medium, and capable of accumulating iron inside of the cells at concentrations 2,000-fold higher than those in the medium. Two tonB-trp deletion mutants, strains B/rlt and B/lt7, which are sensitive to chromic ion and require high levels of iron for normal growth, are deficient in this active transport system. A point mutant, strain Chr2, which is also sensitive to chromic ion and requires high levels of iron for growth, has the active uptake system but cannot synthesize a specific chelator for iron, 2,3-dihydroxybenzoylserine (DHBS). Evidence is presented to support the hypothesis that both the active uptake system and chelation of iron by DHBS play a role in iron uptake from iron-deficient medium. The chromium sensitivity of the mutants can be explained by inhibition of uptake of exogenous iron.


Arabinose-leucine deletion mutants of Escherichia coli B-r. The control of ara gene expression was studied in mutants of Escherichia coli B/r containing deletions which fused the l-arabinose gene complex with the leucine operon (the normal gene order being araDABIOC...leuDCBAO). Complementation experiments with stable merodiploids showed that expression of ara genes cis to araC-leu deletions was controlled by the trans-acting product of the araC gene. Expression of ara genes cis to araB-leu deletions was under leucine control. These studies confirm the existence of a region between genes araC and araB essential for normal activator controlled expression of the ara structural genes. One deletion was characterized as an araO-leu deletion. Its effect on ara gene expression was unique in that ara genes were susceptible to potential regulation by both l-arabinose and leucine. These experiments suggest that two different species of messenger ribonucleic acid (mRNA) may be produced for the ara-leu region as a result of this deletion. One, under l-arabinose-activator control, is initiated in the l-arabinose region; the other, under leucine control, is initiated in the leucine region. The latter indicates that araI can be transcribed. Whether araI is transcribed in the former instance (mRNA made under activator control) remains to be established.


Synthesis of protein, ribonucleic acid, and ribosomes by individual bacterial cells in balanced growth. Relative rates of protein synthesis in individual cells were determined by allowing random populations to incorporate tritiated leucine for very short periods (pulses) and then examining autoradiographs of these cells to assess the amount of incorporation (grains per cell) as a function of cell size. Relative rates of ribonucleic acid (RNA) synthesis were determined in the same way by using tritiated uracil. Unless the uracil pulse was very short (less than 1/20 generation), the RNA labeled during the pulse was predominantly ribosomal. The rate of protein synthesis in individual cells is directly proportional to cell size. The rate of RNA synthesis also increases linearly with size in larger cells, but there appears to be a slight delay in RNA synthesis immediately after cell division. Total cellular content of protein, RNA, and ribosomes is directly proportional to cell size. Thus, we conclude that, in individual cells during the cell cycle (i) the average rate of protein synthesis per ribosome is constant and (ii) the increase in macromolecular mass of the cell is exponential with age.


Antipolarity in the ilv operon of Escherichia coli K-12. The genes governing three of the enzymes of the isoleucine-valine biosynthetic pathway form the operon: operator-ilvA-ilvD-ilvE. The enzymes are: ilvA, l-threonine deaminase; ilvD, dihydroxy acid dehydrase; and ilvE, transaminase B. A nonsense mutation in the ilvD gene (D-ochre) and a nonsense mutation in the ilvE gene (E-amber) affect the properties of the proximal gene product, l-threonine deaminase (TD), in addition to inactivating the enzymes produced by the genes in which the mutations have occurred. The D-ochre mutation causes TD to move in diffusion and gel filtration experiments as though it were 30% smaller than the wild-type enzyme. The E-amber mutation causes TD to move in similar experiments as though it were much larger than the wild-type enzyme. Both mutations completely abolish the sensitivity of TD to l-isoleucine, the normal feedback inhibitor of the wild-type enzyme. The effects of the nonsense mutations on TD can be reversed in three ways: by genetic reversion of the D-ochre mutation; by treatment of the altered enzymes with 3.0 m urea; and by forming a heterozygous diploid, containing the wild-type allele as well as the mutant allele of ilvD or ilvE. The results suggest that the subunits of TD undergo abnormal aggregation in the presence of the partial polypeptides produced by the mutant alleles of ilvD or ilvE; multi-enzyme aggregates in extracts of wild type, however, could not be detected.


Synthesis of desthiobiotin from 7,8-diaminopelargonic acid in biotin auxotrophs of Escherichia coli K-12. The synthesis of desthiobiotin from 7,8-diaminopelargonic acid (DAP) was demonstrated in resting cell suspensions of Escherichia coli K-12 bioA mutants under conditions in which the biotin locus was derepressed. The biosynthetically formed desthiobiotin was identified by chromatography, electrophoresis, and by its ability to support the growth of yeast and those E. coli biotin auxotrophs that are blocked earlier in the biotin pathway. Optimal conditions for desthiobiotin synthesis were determined. Desthiobiotin synthetase activity was repressed 67% when partially derepressed resting cells were incubated in the presence of 3 ng of biotin per ml. Serine, bicarbonate, and glucose stimulated desthiobiotin synthesis apparently by acting as sources of CO(2). The results of this study are consistent with an earlier postulated pathway for biotin biosynthesis in E. coli: pimelic acid --> 7-oxo-8-aminopelargonic acid --> DAP --> desthiobiotin --> biotin.


Membrane alteration and the formation of metachromatic granules in Escherichia coli treated with p-fluorophenylalanine. The effect of p-fluorophenylalanine (FPA) on growing cultures of Escherichia coli was studied with regard to the composition and morphology of the cell envelope. A cell wall fraction was prepared by autolysis in hypertonic medium, and the resulting spheroplasts were osmotically lysed to obtain a cytoplasmic membrane fraction. Incorporation of labeled phenylalanine, FPA, and N-acetylglucosamine into both fractions of FPA-inhibited cells suggested that the composition of the membrane changed with time, whereas that of the cell wall remained relatively constant. Amino acid analysis revealed changes in the composition of the membrane fraction after FPA inhibition. Electron micrographs of shadowed cells and membranes revealed the presence of electron-dense metachromatic granules during the early stages of FPA inhibition.


Kinetics of induction of the lactose operon on an episome in Samonellla typhimurium. A kinetic study of induction of the enzymes of the lactose operon was carried out under conditions known to affect the kinetics of derepression of the enzymes of the histidine operon. The results show that the lactose system is similar to the histidine system in its responsiveness to conditions thought to affect the formylating capacity of the cell. This was demonstrated in the following ways: (i) trimethoprim, which is known to reduce the formylating capacity of the cell, gives rise to a relatively long interval between the times of induction of beta-galactosidase and transacetylase; (ii) under conditions in which the histidine operon is derepressed, chloramphenicol causes a prolongation of the interval between the times of induction of the two enzymes, and this prolongation is reversed by adenine, methionine, and serine, compounds known to enrich the one-carbon pool of the cell; and (iii) 4-amino-5-imidazolcarboxamide ribonucleoside, a compound which may act as a drain for formyl groups, reverses the effect of the latter compounds. The finding that the interval between the times of induction of the two enzymes is shortened under conditions expected to maintain a relatively high intracellular fo rmylating capacity suggests that under certain conditions translation of the polycistronic messenger ribonucleic acid of the lactose operon may be initiated at more than one site or may proceed more rapidly from the operator end.


Synchronous growth of Escherichia coli after treatment with fluorophenylalanine. Treatment of exponentially growing Escherichia coli cells with the amino acid analogue, p-fluorophenylalanine (FPA), resulted in a decrease in the amount of deoxyribonucleic acid (DNA) present per cell. A minimum DNA content per cell was reached approximately 80 min after addition of FPA to the culture. After this time the DNA per cell rose to the level of the untreated cell. When an FPA-treated culture was resuspended in fresh medium containing no FPA 80 min after addition of the analogue, the increases in cell number and DNA became synchronous. Ribonucleic acid was synthesized immediately and continuously throughout the cell cycle, except during periods of DNA synthesis and cell division.


Mutation in Escherichia coli K-12 mediating spherelike envelopes and changes tolerance to ultraviolet irradiation and some antibiotics. In a mutation experiment with a rough, ampicillin-resistant strain of Escherichia coli K-12, two smooth ampicillin-sensitive mutants were isolated. One of the mutants (with the envA gene) was recently described. The second mutant (strain D23) with the envB gene which has been mapped to a position close to streptomycin resistance (strA) at 64 min is described. The envB gene gives rise to spherelike cells. Electron microscopy revealed an abnormal septum formation and a circular distribution of the nuclear material. Strain D23 (with envB) showed a changed resistance to several antibiotics as well as an increased tolerance to ultraviolet irradiation. The envB gene decreased the ampicillin resistance mediated by the ampA gene (at 82 min), but no effect was found on episomally mediated penicillin resistance.


Mechanical removal of F pili, type I pili, and flagella from Hfr and RTF donor cells and the kinetics of their reappearance. The effect of mechanical agitation (blending) on the removal of F pili, type I pili, and flagella from Hfr (high-frequency recombinant) and resistance transfer factor (RTF) fi(+)Escherichia coli cells was studied by electron microscopy. The reduction in number and length of appendages was measured as a function of blendor speed under standard conditions of temperature, medium, cell density, and blendor configuration. F pili and flagella were removed within the same narrow range of blendor speeds. Type I pili were removed within a higher and broader range of speeds. The speed which reduced the average length of type I pili to 50% was 3.5 times the speed which reduced the average length of F pili to 50%. None of the speeds employed inhibited cell growth, viability, or the ability to produce cell appendages. The kinetics of reappearance of F pili and type I pili after removal by blending were also different. F pili grew out very rapidly, reaching 50% of their full length in 30 sec and their full length in 4 to 5 min. The number of attached F pili per cell also increased rapidly, reaching a constant value in 4 to 5 min. After 5 min, F pilus lengths were distributed around a modal value of about 1.2 mum, and the numbers of F pili per cell were distributed according to a Poisson distribution, with an average of 1.0 per cell. These reappearance kinetics, length distributions, and number distributions are consistent with a model of F-pilus outgrowth in which new F pili appear at random locations on the cell surface at an average rate of about once every 4 min, grow to their characteristic length in about 4 min, and then separate from the cell. F pili which had separated could absorb to the cells, leading to the presence of two classes of F pili on cells: those in the process of natural out-growth and those attached by absorption. Type I pili increased in length much more slowly than did F pili, although the fraction of cells having visible type I pili increased very rapidly after blending because of the large number of type I pili per cell. The fraction of flagellated cells increased even more slowly, reaching only 30% of the unblended fraction in 30 min. The application of blending spectra and reappearance kinetics to the identification of cell functions with surface structures is discussed.


Functions of F pili in mating-pair formation and male bacteriophage infection studies by blending spectra and reappearance kinetics. The extent of removal at various blending speeds (blending spectrum) and the kinetics of reappearance after blending of the ability of male Escherichia coli bacteria to form mating pairs, to adsorb and be infected by ribonucleic acid male phage, and to adsorb and be infected by deoxyribonucleic male phage were identical to the blending spectrum and reappearance kinetics of microscopically visible F pili. The same results were obtained with an Hfr (high-frequency recombinant), F', or resistance transfer factor (RTF) fi(+) mating system. Blending did not affect the viability, growth rate, ability to adsorb T4 phage, or ability to produce new F pili at any of the speeds used. It can be concluded that microscopically visible F pili are an absolute requirement for all three functions. Three classes of F pili have been found in bacterial cultures: attached, adsorbed, and free. Bacteria with adsorbed F pili in addition to attached ones were proportionately more susceptible to male phage infection, suggesting that adsorbed F pili may be at least partially functional. Free F pili did not compete with bacteria for phage. Some implications of the virus-like nature of F-pilus outgrowth for the mechanisms of mating and male phage infection are discussed.


Changes in the plasma membrane of Escherichia coli during magnesium starvation. The effect of Mg(++) starvation on the structure of the Escherichia coli cell membrane was studied with the freeze-etch technique. Special attention was paid to changes within the plane of the membrane, which in normal exponentially growing cells has a netlike arrangement of particles 2 to 6 nm in diameter. During Mg(++) starvation, a paracrystalline particle pattern appeared on the plasma membrane, and large areas devoid of particles were seen. Although these changes are reproducibly associated with Mg(++) starvation of the bacteria, no decrease in the Mg(++) content of the cell envelope per se was detected, even after 24 hr of Mg(++) deprivation. The structural changes caused by Mg(++) deprivation appeared to involve specific and permanent alterations in membrane development. The absence of other nutrients or divalent cations did not induce similar alterations.


Estimate of the genome size of various microorganisms. Bacterial genome sizes, determined by deoxyribonucleic acid reassociation kinetics, vary over a 10-fold range. The smallest studied, Chlamydia trachomatis, had a genome of 6 x 10(5) nucleotide pairs compared to 4.5 x 10(6) for Escherichia coli.


Crystalline inclusions of bacterium 22M. Crystalline inclusions occur in bacterium 22M. Arrays consist of parallel rows of polyhedral subunits (7.5 nm in diameter), 2.0 nm apart, with a distance of 3.0 nm between rows.


Induction by mercuric ion of extensive degradation of cellular ribonucleic acid in Escherichia coli. Low concentrations of HgCl(2) were found to induce extensive degradation of ribonucleic acid (RNA) in exponentially growing Escherichia coli cells but not in stationary-phase cells. Whereas 80% of cellular RNA was degraded during 90 min of incubation with 10(-5)m HgCl(2) at 37 C, HgCl(2) caused only slight degradation in stationary cells, even when present at concentrations higher than 5 x 10(-5)m. Inhibition of RNA synthesis occurred at almost the same concentration of HgCl(2) as degradation, and the ability of stationary-phase cells to synthesize RNA was also resistant to HgCl(2). The transition of cells from complete sensitivity to HgCl(2) to a fully insensitive state took place simultaneously with the cessation of growth. p-Chloromercuribenzoate was also found to induce remarkable degradation of RNA. In E. coli Q13, a mutant deficient for ribonuclease I, no degradation of RNA was evident, even in the exponential growth phase. 3'-Mononucleotides but not 5'-mononucleotides were found among the degradation products of cellular RNA. 2',3'-Cyclic mononucleotides were produced when RNA was degraded by the cell-free extracts of the Hg treated cells. Almost complete unmasking of the latent ribonuclease occurred in the particle fraction containing subribosomal particles of the Hg-treated cells. These data suggest that the incubation of exponentially growing E. coli cells with HgCl(2) led to the unmasking of ribonuclease I, which resulted in the extensive degradation of cellular RNA. The activation of ribonuclease by HgCl(2) in the isolated particulate fraction of E. coli K-12 which occurred in vitro suggested the presence of an Hg-sensitive inhibitor for ribonuclease I.


Recombination between a thermosensitive kanamycin resistance factor and a nonthermosensitive multiple-drug resistant factor. The thermosensitive kanamycin (KM) resistance factor, R(KM)(t), and a nonthermosensitive multiple-drug resistance factor, R(100), were simultaneously introduced into Escherichia coli and Salmonella typhimurium. The temperature sensitivity of both R factors remained unchanged as long as they replicated independently. Under certain conditions, however, a new thermosensitive R factor harboring resistance markers for kanamycin, streptomycin (SM), and sulfanilamide (SA) was obtained by recombination between the R(KM)(t) and R(100) factors. R factors carrying resistance markers for KM and SA, or for SM and SA, were obtained from the recombinant R(KM SA SM)(t) by spontaneous segregation. Though the R(100) factor has been known as an fi(+) (positive for F-mediated fertility inhibition of its host) type and it does not restrict any coexisting phages, the thermosensitive recombinants of R(100) with R(KM)(t) and their segregants were found to be fi(-) and to restrict the replication of all T-even phages, as does the R(KM)(t) factor. Double infection immunity was not observed between the R(KM)(t) and R(100) factors.


Killing and lysis of gram-negative bacteria through the synergistic effect of hydrogen peroxide, ascorbic acid, and lysozyme. A mixture of hydrogen peroxide and ascorbic acid has been found to generate an antibacterial mechanism which is active against gram-negative bacteria. It results in bacterial death and renders the organism sensitive to lysis by lysozyme. Under the conditions used, horseradish peroxidase did not augment the antibacterial effect. It is suggested that the effector mechanism involves the generation of short-lived free radicals which disturb the integrity of the cell wall. This effect alone might kill bacteria by interfering with selective permeability, but in the presence of lysozyme a further bactericidal activity is accomplished by complete disruption of the cell. It is proposed that a transient antibacterial system such as that described could exist within phagocytic cells. Free radicals would be formed through the interaction of certain oxidizable substances and hydrogen peroxide, which is produced during the enhanced metabolic activity that accompanies ingestion of bacteria. Such a system would help to explain why macrophages, which are apparently devoid of preformed bactericidins, are nonetheless very efficient in killing most phagocytosed bacteria.


Characteristics of a new sterol-nonrequiring Mycoplasma. Two Mycoplasma strains recovered from tissue culture environments were found to grow in complex media devoid of serum or serum fractions containing cholesterol and in a cholesterol-free synthetic medium. Neither strain was capable of synthesizing pigmented carotenoids, although these compounds are present in, and characteristic of, other sterol-nonrequiring mycoplasmas. Serological tests and an analysis of their cell protein patterns obtained by gel electrophoresis indicated that the isolates were similar to each other but distinct from other sterol-nonrequiring serotypes, Mycoplasma laidlawii and M. granularum, as well as from sterol-requiring species. The existence of Mycoplasma other than M. laidlawii and M. granularum without sterol requirements suggested the need for some taxonomic changes in this group of organisms.


A quantitative analysis of the normal neuron population of the hypothalamic magnocellular nuclei in man and of their projections to the neurohypophysis.


Projections of the inferior colliculus in cat.


Experimental production of lethal Escherichia coli bacteremia of pelvic origin. To reproduce the syndrome of overwhelming Escherichia coli bacteremia and shock after pelvic instrumentation, a model was developed by feeding E. coli via drinking water to coliform-free rabbits, injecting nitrogen mustard intravenously, and inserting a temperature probe into the rectum. The temperature probe was inserted to mimic pelvic instrumentation of patients and to detect fever. Rabbits fed invasive serotypes of E. coli all suffered overwhelming bacteremia with high fever and fatal vascular collapse secondary to invasion of pelvic veins as the granulocyte count approached zero. In the absence of granulocytopenia, the rectal temperature probe produced an intensive inflammation with numerous polymorphonuclears and bacteremia did not develop. In the absence of rectal probing, granulocytopenic rabbits developed high fever without bacteremia. This model resembles human bacteremic shock with respect to the endogenous source of the bacteria, the high frequency of bacteremia due to E. coli and other enteric bacilli, the importance of pelvic instrumentation, and the associated immune disturbances such as granulocytopenia.


A phytochemical and biological review of the genus Croton.


The Armed Forces Institute of Pathology--a national resource.


Mechanism of action of gentamicin.

Mechanism of action of gentamicin.


Antibiotic sensitivities of nonpigmented serratia marcescens to gentamicin and carbenicillin.


Mechanical ventilation of newborn infants. I. The effect of rate and pressure on arterial oxygenation of infants with respiratory distress syndrome.


R factors for aminoglycoside antibiotics.


Gentamicin in infections of the central nervous system.


Gentamicin in the treatment of meningitis in neonates.


Effects of adrenalin and anaphylaxis on the aggregation of the cellular constituents of the blood in vivo.


Mortality and skeletal malformations from amniocentesis and oligohydramnios in rats: cleft palate, clubfoot, microstomia, and adactyly.


Antigenic identity of culture 193T-64 and E. coli 0136:K78(B22).


Drugs affecting smooth muscle.

Drugs affecting smooth muscle.


Mechanisms of general anesthesia by non-hydrogen-bonding molecules.


Behavioral pharmacology and toxicology.

Behavioral pharmacology and toxicology.


Toxicology of ethanol.

Toxicology of ethanol.


Effects of oral contraceptives.

Effects of oral contraceptives. This review was limited to topics of current concern with respect to the use of oral contraceptives (OCs).  Thromboembolism, liver injury, fertility and infertility, miscellaneous adverse effects (such as headaches and psychological and metabolic effects), and acceptance were the topics covered.  It was found that the risk of death due to pulmonary embolism or cerebral thrombosis among users of OCs amounted to 1.5 per 100,000 women aged 20-34 years as against .2 for a comparable group not using drugs; for users 35-44 years old the  risk rose to 3.9 per 100,000 compared to .5 for nonusers.  The increased risk associated with suppression of lactation by administration of diethylstilbestrol was most striking among women over 25 years of age; in this group the risk was 10-fold greater than that of lactating mothers.  1 report suggested that women with pulmonary hypertension due to congenital heart disease should probably not receive OCs.  Contraindications to the use of OCs must now include any history of thromboembolic disease or disorders of the blood-clotting mechanism.  There appeared to be a predisposing factor among women who develop jaundice while taking OCs.  A remarkable number of such subjects had had idiopathic jaundice of pregnancy.  There seems to be little evidence for permanent liver damage but very definite evidence for bile stasis and transient morphological changes.  Much more work needs to be done before any adverse effect on fertility is established.  In cases where fertility reduction is suspected, it must be demonstrable that fertility prior to the use of OCs was unimpared.  Among 20 patients on OCs who had had migraine, the attacks became more intense and their frequency increased for 15 of the 20 patients.  Generally speaking, those using the intrauterine device (IUD) were more persistent in accepting the method than those on OCs probably because the IUD may be used more extensively than OCs in underdeveloped countries.


Chemotherapy of leprosy.

Chemotherapy of leprosy.


New substances of plant origin which increase nonspecific resistance.


Cancer chemotherapy.

Cancer chemotherapy.


Physiological and pharmacological aspects of the platelet.


Review of reviews.

Review of reviews.


Insulin and glucagon release from isolated islets of Langerhans. Effect of enteric factors.


Plasma insulin response to an oral carbohydrate solution.


Epileptic discharges occurring in the mesencephalon and thalamus.


Spontaneous cure of limbic system epilepsy in the cat.


Action of phenobarbitone on neocortical amino acid changes induced by a spiking focus.


Stewart George Wolf: our new president.

Stewart George Wolf: our new president.


Combating malnutrition through maternal and child health programs.


Biological effects of gastrointestinal antibodies. I. The production of antibodies to components of adult and fetal guinea pig gastric and colonic mucosa.


Reticulum cell sarcoma.

Reticulum cell sarcoma.


A rapid method for processing early mouse embryos for light microscopy.


A comparison of mesoridazine and chlorpromazine in chronic psychiatric patients.


Trimethroprim and sulfalene therapy of Plasmodium vivax.


Two pilot studies of AHR-1680 in chronic schizophrenic patients.


Microincineration as a new method for electronmicroscopical investigations of bull sperm.


Doppler shifted ultrasound. History and applications in clinical medicine.


Wilford Hall USAF Hospital.

Wilford Hall USAF Hospital.


Effect of rifampicin on the radiation sensitivity of several strains of Escherichia coli.


Bibliography of housekeeping educational aids.


Absorption of microwaves by microorganisms.


Special needs of children handicapped by spina bifida.


Interaction of x-ray, ultraviolet light, and thymineless incubation in killing 5-bromodeoxyuridine-grown bacteria.


Operational R.M.P.'s and the areas they cover.


Comparative protection by a combination treatment in mice irradiated with fission neutrons or x-rays.


Pulse-irradiated bacterial survival in the presence of nitric oxide.


The clinical appearance of hand, foot and mouth disease.


The development and application of microsurgery.


The presidential address. Advancing knowledge.


The operating microscope. Past, present and future.


Discussion.

Discussion.


Medical care in the United States.

Medical care in the United States.


The present position of therapeutic keratoplasty especially in relation to the treatment of herpes simplex of the cornea.


The management of ocular herpes.

The management of ocular herpes.


The 'apex' contact lens.

The 'apex' contact lens.


Some unusual grafts.

Some unusual grafts.


The treatment of severely damaged rats.

The treatment of severely damaged rats.


Valentine  Greatrakes--ophthalmologist (1628-1683).


Vascular lesions in trypanosomiasis.

Vascular lesions in trypanosomiasis.


Quantitative epidemiology of tropical diseases.


The fine structure of Trypanosoma (Trypanozoon) brucei.


A bug trap which failed.

A bug trap which failed.


Drug resistance in malaria--a perspective.


Meiotic division in oöcysts of malaria parasites of mammals.


The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis.


Some special kinetic problems of transport.


Dynamic three-dimensional model for enzymic transamination.


Regulation of enzymes by enzyme-catalyzed chemical modification.


Alkaloid biosynthesis.

Alkaloid biosynthesis.


Aspects of visual pigment research.

Aspects of visual pigment research.


Trichomonas vaginalis and trichomoniasis.


Coccidia and coccidiosis in the domestic fowl.


Experimental trichiniasis.

Experimental trichiniasis.


The infectious process, and its relation to the development of early parasitic stages of nematodes.


Timely topics in clinical chemistry: serum lipids.


Larvae and larval development of monogeneans.


Effects of intermittent photic input on brightness, hue, saturation, visual acuity, and stereopsis.


The luminous transmission ftor of sunglasses.


Medical descriptions in early Australian history.


Hair growth cycles in subcutaneous implants.


Tryptophan synthase from Nicotiana tabacum.


Cell preparation for the assay of threonine dehydratase in Escherichia coli.


Electron-microscopic investigation of Escherichia coli glutamate decarboxylase.


Historical reflections on the changing concepts of disease.


Loma Linda University School of Medicine.


Heart transplantation--report of a case.


Mitochondrial antibody test--a clue to diagnosis of primary biliary cirrhosis. Report of two interesting cases.


Effect of anti-epidermins antibodies on autografts in rats and rabbits.


Cryoglobulins in New Zealand Black mice.


Immunofluorescent demonstration of an IgG-B1C complex in synovial lining cells of rheumatoid synovial membrane.


Pharmacological control of reproduction in women.


Radiosensitization by potassium iodate and related compounds.


Nutrition, body fat and physical fitness.


Radiolysis and radioprotective effect of glutathione.


Radiosensitization of bacterial cells by carbonyl compounds.


Herman Von Helmholtz.

Herman Von Helmholtz.


If you're not part of the solution, you're part of the problem. PTOMETRY's Viet Nam.


Replication of deoxyribonucleic acid in Escherichia coli under limited supply of oxygen.


Sensitivity of Escherichia coli to viral nucleic acid. II. Development of competence in Escherichia coli CT during growth in a hypertonic medium.


Regulation of thiamine biosynthesis in Escherichia coli.


Thiamine regulatory mutants in Escherichia coli.


O-alkylhomoserine and methionine biosynthesis in Corynebacterium.


Mechanism of inhibition of protein synthesis by fusidic acid and related steroidal antibiotics.


Differentiation of institutional adjustment of juvenile delinquents with the Hand Test.


Experimental falsification of the Hand Test.


The height of figure drawings related to IQ, sex and CA in mental retardates.


Ovulation in the guinea-pig.

Ovulation in the guinea-pig.


Tobacco-poisoning and its effects upon the eye-sight.


Michigan State Medical Society Directory.


Luteinizing hormone releasing activity of crude ovine hypothalamic extract in man.


Delayed-type hypersensitivity in mice after skin and tumour allografts and tumour isografts.


Role of the initiation factor in the response of 70S ribosomes to R17 RNA.


Concept of hysteria. History and re-evaluation.


Substructures in ribosomes of E. coli? A hypothesis for the attachment of transfer RNAs.


Appreciation. Joseph Earle Hiltz.

Appreciation. Joseph Earle Hiltz.


Summary of the present situation and needs for future development.


Quality health care and the federal government.


Relationship between original renal disease and fate of renal allografts.


A critique of implantation of a systemic artery for myocardial revascularization.


Exercise stress testing in evaluation of patients with ischemic heart disease.


The correlation of ultrastructure and function in the mammalian myocardial cell.


The pharmacology of beta-adrenergic blocking agents.


The use of drugs in achieving successful DC cardioversion.


Contact hypothesis in ethnic relations.

Contact hypothesis in ethnic relations.


Significance of posture and posiion in the communication of attitude and status relationships.


Psycho-social deprivation and achievement dispositions: present knowledge and needed research.


Independence, dependence, manifest and latent masculinity-femininity: some complex relationships among four complex variables.


Contrast effect on subjective experience in drug experiments.


Freund's adjuvants.

Freund's adjuvants.


The Night of the Long Knives.

The Night of the Long Knives.


Practical considerations in keratoplasties.


A century minus five.

A century minus five.


Reflections on some benigniseases of the esophagus.


Canine lung allotransplantation.

Canine lung allotransplantation.


Investigation into the carrying ability of pedicled bone grafts during transplantation.


Studies on oral enzymes. VII. Pyridoxal-5-phosphate dependent cleavage of L-cystine and related compounds by enzyme preparations from human oral cavity and certain microorganisms.


Stranger's fever in Eighteenth century Charleston.


Clearance studies of proximal tooth surfaces. I.


Nathan Bozeman.

Nathan Bozeman.


Vitamin B6-dependency syndromes. New horizons in nutrition.


The initiation of protein synthesis.

The initiation of protein synthesis.


Andrew J. Donnelly, M.D., 1910-1968.

Andrew J. Donnelly, M.D., 1910-1968.


Julius Shaw Weingart, M.D., 1881-1968.

Julius Shaw Weingart, M.D., 1881-1968.


Anthony J. Telego, M.D., 1917-1968.

Anthony J. Telego, M.D., 1917-1968.


The pontine arteries in vertebral angiography.


Extra-ventricular (communicating) hydrocephalus: some observations on the midline ventricles.


Clinical experiences with a new type of contrast medium in peripheral arteriography.


Studies in the prevention of complications of angiography.


Use of a pressure-cycled respirator (Bird) in respiratory failure due to severe obstructive pulmonary disease.


Positive antinuclear factor in patients with unexplained pulmonary fibrosis.


Septic arthritis complicating rheumatoid arthritis.


Nationally speaking.

Nationally speaking.


Temporary control of tracheal-innominate artery tistula.


The period and nature of hazard in clinical renal transplantation. 3. The hazard to transplant kidney survival.


Clinical inference in psychodiagnostics.


Assessment of acid-base disorders. A practical approach and review.