Inhibition of synthesis of phiX174 DNA in a mutant host thermosensitive for DNA synthesis.


Different specificity of yeast transfer enzymes for Escherichia coli ribosomes.


On being liked more than you like.

On being liked more than you like.


Chemical mace: a non-lethal weapon.

Chemical mace: a non-lethal weapon.


Bernhard Bang, (1848-1932) veterinary physician.


Combination therapy of malaria.

Combination therapy of malaria.


Decubitus ulcer. A double blind study of an old problem and a new treatment.


Enteritis in Manchester.

Enteritis in Manchester.


Comparison of technics for the isolation of T-strain mycoplasmas.


Nucleotide sequence of E. coli B tRNA1-Val.


Whither multiphasic screening?

Whither multiphasic screening?


Medium-chain triglycerides.

Medium-chain triglycerides.


Gamma-M-fluorescent treponemal antibody in the diagnosis of congenital syphilis.


Rejection of the transplanted human heart.


Development of reticulum-cell sarcoma at the site of antilymphocyte globulin injection in a patient with renal transplant.


Heart transplantation, problems and progress.


Half a century old.

Half a century old.


Induction of labor by intra-amniotic instillation of hypertonic solution for therapeutic abortion or intrauterine death.


Rhinoplasty and the face.

Rhinoplasty and the face.


Failure to increase the survival of experimental flaps by histamine and hypertension.


Mucous cysts of the fingers.

Mucous cysts of the fingers.


Clinical applications of the scalping flap in reconstruction of the nose.


Night operations on burned patients.

Night operations on burned patients.


Lymphatic vascularization of skin grafts.


The classic reprint: a case of fracture of the lower jaw with remarks on the treatment. Case report.


Single Steinmann pin fixation of arm to leg. Case report.


Further investigations on application of 24Na for the evaluation of blood supply to the lower extremities in arteriosclerosis obliterans.


The crystallization of the lipid mantle of the skin in aqueous solutions of ethoxy-diaminoacridine lactate.


The management of portal hypertension.

The management of portal hypertension.


Eyelid sutures in intraocular surgery.

Eyelid sutures in intraocular surgery.


Frederick Herman Verhoeff 1874-1968.

Frederick Herman Verhoeff 1874-1968.


William Lemuel Benedict 1885-1969.

William Lemuel Benedict 1885-1969.


Harvey Cushing.

Harvey Cushing.


In vitro polypeptide synthesis in brain.


The sulfhydryl groups of citrate cleavage enzyme.


L-asparaginase: inhibition of endogenous RNA polymerase activity in regenerating liver.


Regulation of phosphoenolpyruvate carboxykinase in Escherichia coli by carbohydrate metabolism.


Effect of alcohols on the enzymatic activity and subunit association of beta-galactosidase.


The significance of biliary pressure in cholangitis.


Properties and catalytic activities of vitamin B6 N-oxide.


Lichen planus: a dermatological centenary.


Selected list of books and journals for the small medical library. This updated list of 398 books and 141 journals is intended as a selection aid for the small library of a hospital, medical society, clinic, or similar organization. Books and journals are arranged by subject, with the books followed by an author index, and the journals by an alphabetical title listing. Items suggested for first purchase by smaller libraries are noted by an asterisk.


Characterization of rabbit fast and slow 6-6S IgG.


Congenital abnormalities of the limbs in still-births. A study of 12 fetuses.


The effects of endotoxin on vascular endothelium. This study was undertaken to develop a technique for the preparation of sheets of endothelial cells and to investigate the effects of bacterial endotoxin on large numbers of cells from continuous sheets of vascular endothelium. Rabbits were divided into one control and two experimental groups. The experimental animals received intracardially an LD(50) dose of Escherichia coli endotoxin. 1 and 24 hr postinjection, the vessels of the animals were perfused with glutaraldehyde in Millonig's buffer with methylene blue as a marker. Pieces of mesentery containing arteries were postfixed in buffered glutaraldehyde, dehydrated, and placed in acetone (to remove fat deposits). The surrounding connective tissue was stripped from the mesenteric arteries, and segments of the vessels were slit longitudinally, flattened out, and firmly affixed to a sheet of cork with fine mounting pins. A 3% solution of Formvar in ethylene dichloride was pipetted onto the luminal surfaces of the vessels. The endothelial cells were impregnated with and adhered to the Formvar and, after soaking overnight in 10 N NaOH, could be stripped from the vessel walls as monolayers. Sheets of Formvar-impregnated cells were temporarily mounted on glass slides in aqueous methylene blue and examined by phase and bright-field microscopy. Methylene blue stained the nuclei a deep blue and the cytoplasm faintly, but cell outlines were indistinct. Endothelial sheets from control rabbits had smooth, elliptical nuclei oriented parallel to the longitudinal axis of the cells and irregularly distributed over a smooth background with faint longitudinal striations. Essentially every cell in endothelial sheets from endotoxin-injected animals appeared to be severely damaged. Cell sheets from 24 hr posttreatment animals exhibited the same type of, but more extensive, damage than that observed in 1 hr posttreatment animals. The most prominent features of the damaged endothelium were distorted nuclei, apparent nuclear vacuolization, and missing nuclei. Unstained platelets and plaques were present on the surfaces of the specimens from the experimental animals only. Stained and unstained red blood cells were also dispersed over the luminal surfaces of the endotoxin-treated vessels.


Cellular differentiation of the immune system of mice. 3. Separate antigen-sensitive units for different types of anti-sheep immunocytes formed by marrow-thymus cell mixtures. Marrow cell suspensions of unprimed donor mice have been transplanted into X-irradiated syngeneic hosts. 5-46 days later, bone cavities and spleens contained regenerated cells of the immune system which required interaction with thymocytes (from intact donors) and antigen (SRBC) to form antigen-sensitive units (ASU) and to generate mature immunocytes. These cells were capable of differentiating either into direct or indirect hemolytic plaque-forming cells (PFC). The precursors of PFC regenerated earlier than the other cell type necessary for immunocompetence, the antigen-reactive cell (ARC). The latter was not found until 10 or more days after transplantation. Availability of ARC was inferred from PFC responses elicited by grafted mice challenged with SRBC at varying intervals. In a second series of experiments, graded numbers of marrow cells (ranging from 10(7) to 5 x 10(7)) were transplanted with 5 x 10(7) or 10(8) thymocytes into irradiated mice, and SRBC were given 18 hr later. After 9-12 days the recipient spleens contained all or some of the following immunocytes: direct and indirect PFC, and hemagglutinating cluster-forming cells. The frequency of each immune response varied independently of the others, but in relation to the number of marrow cells grafted. This was interpreted to indicate that ASU formed in irradiated mice by interaction of marrow and thymus cells were similar to those of intact mice. In particular, they were specialized for the molecular class (IgM or IgG) and function (lysis or agglutination) of the antibody to be secreted by their descendent immunocytes. Hence, class-differentiation appeared to be conferred upon ASU by their marrow-derived components.


Effect of morphine upon maternal capillary blood oxygen and carbon dioxide tension.


Epinephrine in pulpotomy.

Epinephrine in pulpotomy.


Oral findings of mentally retarded children.


Natural and acquired antibodies to Plasmodium lophurae in intact and bursaless chickens. I. Agglutination and passive  immunity studies.


In memoriam. David Henry Wenrich.

In memoriam. David Henry Wenrich.


Preoperative medications in operative dentistry for children.


Editorial: Attitudes of our people.

Editorial: Attitudes of our people.


Public relations relies on the motion picture, "The Double Day of Danny Dillon".


Malnutrition and brain development.

Malnutrition and brain development.


Maternal anxiety and child behavior.

Maternal anxiety and child behavior.


Acrodermatitis enteropathica: defective metabolism of unsaturated fatty acids.


Pyogenic hepatic abscesses in infancy and childhood.


Serum bacterial opsonins and polymorphonuclear leukocytes in mothers and newborns.


A new double medication method for the treatment of alcoholism using the drug cyanamide.


Citations and citation indexes: a review.


Ruth G. Whitfield.

Ruth G. Whitfield.


Regulation of immunity at the cellular level.


The in vivo interaction of Candida albicans and Salmonella typhimurium.


The growth of Candida albicans and Salmonella typhimurium in mixed cultures.


Controlled trial comparing effect of two and six weeks' treatment in recurrent urinary tract infection. Patients with recurrent urinary tract infection were allocated at random to two weeks' or six weeks' treatment with an appropriate antibacterial drug. There was no difference in the results achieved by the two different periods of treatment as judged by the presence of infection in the urine one week and six weeks after treatment was stopped.The urine was clear of infection in a higher percentage of patients following a course of nitrofurantoin than following a course of ampicillin, but the difference was not significant.


Simultaneous determination of the capacity of the vascular bed and capillary blood flow in the normal myocardium of the rat and in two types of experimental necrosis.


The heritage of Hippocrates.

The heritage of Hippocrates.


John Hughes Bennett (1812-1875), clinical teacher of Edinburgh.


Commercially available culture materials.


G 30 320 or B 663--lampren (Geigy).

G 30 320 or B 663--lampren (Geigy).


Second trial of low dosages of DDS in lepromatous leprosy.


A case of extreme keratectasia treated with keratoplasty.


Vascular smooth muscle. I. Normal structure, pathology, biochemistry, and biophysics.


Chromium occurrence and function in biological systems.


Brown fat and thermogenesis.

Brown fat and thermogenesis.


Effects of septal lesions in rats on plasticity of autonomic functions after an extended postoperative recovery period.


Nipple shields.

Nipple shields.


Changing times.

Changing times.


Images of woman: past and present, overt and obscured.


Asklepios: a myth to remember.

Asklepios: a myth to remember.


Michael Francis Hickey.

Michael Francis Hickey.


Mary Eleanor Edelsten-Pope.

Mary Eleanor Edelsten-Pope.


Common sense in chemotherapy.

Common sense in chemotherapy.


Studies in rubella: observations in elective infection of human volunteers: clinical and laboratory aspects.


Inactivation of stem cells after transplantation of mixtures of haemopoietic or lymphoid cells of different genotypes.


Transplanted rat heart: local graft irradiation.


The immunosuppressive activity of ara-cytidine (cytarabine). 3. Effects of canine renal allograft rejection and hemagglutinin formation.


Retrospective leukocyte typing of unrelated human donor-recipient pairs in relation to skin allograft survival times. A study of 17 well defined specificities.


The effects of cytosine arabinoside on canine renal allografts.


Cutaneous reactions in mice injected intradermally with cells from heavily irradiated syngeneic donors.


Degeneration and regeneration of adrenergic nerves in the autotransplanted kidney.


Prolongation of skin allograft survival in mice by an antiserum to calf thymosin.


Everting versus inverting gastrointestinal anastomoses: bacterial leakage and anastomotic disruption.


Early excision and grafting in third degree burns.


Nucleotide sequences at the 5'-termini of in vitro synthesized RNA.


On the effect of divalent cations and protein concentration upon renaturation of beta-galactosidase from E. coli.


Airways flow resistance as a measure of the efficacy of inhalants in clinical drug trials.


Clinical pharmacology of bronchospasmolytics in the asthmatic.


Cooperation between hospitals and ECF's solves bed location problem.


Pituitary and hypothalamic endocrine changes during the bovine estrous cycle.


Suppression of urinary excretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) by medroxyprogesterone acetate.


Acute hemodynamic effects of adult renal allografts on neonatal puppies.


A method for the simultaneous determination of the secretion rates of cortisol, 11-desoxycortisol, corticosterone, 11-desoxycorticosterone and aldosterone.


Herbert E. Coe, 1881-1968.

Herbert E. Coe, 1881-1968.


Growth and function of the replanted lung in young dogs.


Tooth-supported complete dentures: an approach to preventive prosthodontics.


Accurate casts.

Accurate casts.


Technique of splint contouring in resected edentulous mandibular reconstruction.


Recognition and management of airway obstruction.


Corticosteroids in bronchiolitis.

Corticosteroids in bronchiolitis.


Alois Alzheimer (1864-1915). Neurohistopathologist.


Hormones and gene transcription.

Hormones and gene transcription.


Anesthetic problems in patients on maintenance dialysis.


Athletics, activity and personality: a review of the literature.


The correct spelling of Miss Beecher's name, "Catharine" or "Catherine.


Urinary infection.

Urinary infection.


A comparative study of the treatment of urinary infection.


Acute arterial injuries to the extremities.


Thiabendazole. Clinical trial in treatment of strongyloidiasis in six children.


Regulation of dihydrofolate reductase and other folate-requiring enzymes.


Marek's disease: a review.

Marek's disease: a review.


Multifocal gastric heterotopia in a malformation of the colon presenting as a megacolon.


Effect of selective coronary arteriography on myocardial blood flow in the intact dog.


Hydrops fetalis. Antenatal diagnosis and treatment.


Editorial: The American Board of Orthodontics: a historic milestone.


The graves of John Snow and Joseph Thomas Clover.


Presentation of the Martin Dewey Memorial Award by Harry H. Sorrels, Chairman of Award committee.


Was a pebble in Demosthenes' mouth a primitive obturator?


Graphical estimation of the number of strong histocompatibility antigens present in renal homografts.


Audition.

Audition.


Perception.

Perception.


Color vision.

Color vision.


The physiological basis of memory.

The physiological basis of memory.


Electrical stimulation of the brain in behavioral context.


Epidemiological studies of college mental health.


Acrylamide gel electrophoresis of group A streptococcal cell walls. Patterns obtained by acrylamide gel electrophoresis of group A streptococcal cell walls were characteristic for M types 1, 2, 3, 4, and 5, respectively. Best results were obtained with cell walls which had been solubilized with a phenol-acetic acid-water mixture. The method will make it possible to compare group A streptococci of epidemiological and clinical significance and to separate components for more critical analysis.


Studies on the immune bacteriolysis. 13. Leakage of enzymes from Escherichia coli during immune bacteriolysis.


[Studies on the immune bacteriolysis. XIV. Requirement of all nine components of complement for immune bacteriolysis].


Alanosine and hadacidin--comparison of effects on adenylosuccinate synthetase.


Antigenic structures of hen egg white lysozyme. II. Significance of the N-and C-terminal region as an antigenic site.


Deusexmachina vocis. An analysis of the laryngeal reflex mechanisms of speech.


Speech pathology and audiology in the United States.


Half a century of health care...

Half a century of health care...


The letters of Dr. Neil Macvicar of Blantyre. V. 16. Portion of medical report (incomplete) undated, written by Neil Macvicar probably in 1898.


Gentamicin--a new antibiotic.

Gentamicin--a new antibiotic.


Unusual pulmonary diseases.

Unusual pulmonary diseases.


Drugs used in the treatment of cardiac arrhythmias.


Studies on the histidine transaminating enzyme of Escherichia coli.


Merits of special class, resource, and itinerant plans for teaching partially seeing children.


Chemical mace--a controversy.

Chemical mace--a controversy.


Aerosol corticosteroid treatment of vasomotor rhinitis.


Adam Politzer and his pupils.

Adam Politzer and his pupils.


The fine structure of the mitral valve in allotransplanted hearts.


Current concepts of depression: the sociocultural.


Studies on the testis as an 'immunologically privileged' site.


The ultrastructure, histochemistry and hormone content of some reptilian endocrine pancreases.


Hunterian Lectures. Man's Posture: Its Evolution and Disorders, given at the Royal College of Surgeons of England by Professor Sir Arthur Keith, F.R.C.S., F.R.S., conservator of the museum. Theories concerning the evolution of Man's Posture.


A history of anatomy in Dublin.

A history of anatomy in Dublin.


Motivation and learning in relation to empathy and identification. II. Learning.


Separation of the diastereoisomers of 3-hydroxyglutamic acid by ion-exchange chromatography.


Messenger RNA-associated 30S ribosomal subunit: extraction from E. coli and the effect of chloramphenicol on the content.


Teeth and threatening look in the Draw-A-Person test as indicating aggression.


Expansiveness-constriction on the H-T-P as indicators of extraversion-introversion.


Performance of overt male homosexuals and controls on the Blacky test.


Sir Henry Dale, O.M., G.B.E., F.R.S. (1875-1968).


The Graham Steell murmur mimicked by the murmur of mitral stenosis.


Effects of gastrin on the release of insulin in vitro.


Fragments of MS2 RNA as messengers for specific bacteriophage proteins: fragments from fluorouracil-containing particles.


Dr. W. N. Pickles.

Dr. W. N. Pickles.


Pressure sores.

Pressure sores.


Congenital deformities. I. Primary bone graft in clefts of lip, alveolus and palate.


Design of local flaps.

Design of local flaps.


Injuries of the facial skeleton.

Injuries of the facial skeleton.


Cues affecting eating behavior and obesity.


Zinc and reproduction.

Zinc and reproduction.


Glyceride structure and fat absorption.

Glyceride structure and fat absorption.


Dietary foodstuffs, growth, and biochemical parameters.


Factors affecting the cellularity of adipose tissue.


The components of energy expenditure in the rat.


Experimental amyloidosis and diet.

Experimental amyloidosis and diet.


Gastrointestinal milk allergy in infants.


Preservation and utilization of the components of human blood.


The control of human hemoglobin synthesis and function in health and disease.


Newer tracer techniques in hematology.

Newer tracer techniques in hematology.


Central effects of metronidazole.

Central effects of metronidazole.


A review of the use of a thiazole derivative (hemineurin) in delirium tremens and allied conditions.


Trends in the prevention of alcoholism.

Trends in the prevention of alcoholism.


Prognostic factors in alcoholism.

Prognostic factors in alcoholism.


Maryland alcoholics: follow-up study 1.

Maryland alcoholics: follow-up study 1.


Willis F. Kraemer, M.D. 1914-1968.

Willis F. Kraemer, M.D. 1914-1968.


A review of children's reports of parent behaviors.


Modern trends in arthroplasty of the hip.


On modification of total prosthesis.

On modification of total prosthesis.


Vascular reactions after tendon suture and tendon transplantation. A stereo-microangiographic study on the calcaneal tendon of the rabbit.


Common mechanisms of hypotension in irreversible shock and liver transplantation.


Achalasia and carcinoma of the esophagus.


Angiographic investigation of hypertension complicating human renal transplantation.


Wisdom in the pursuit of excellence. A history of the Pacific Coast Oto-Ophthalmological Society.


Wine and otolaryngology.

Wine and otolaryngology.


Steroid therapy in penetrating keratoplasty.


I. William Osler's education.

I. William Osler's education.


John H. Houghton, M.D.

John H. Houghton, M.D.


Wounds of the chest in war and peace, 1943-1968.


Functional evaluation of lungs transplanted after varying ischemic intervals and after preservation by mechanical ventricular assistance.


Asymmetric transcription of B. subtilis phage SPP1 DNA in vitro.


The formation of a complex containing ribosomes, transfer factor G and A guanosine nucleotide.


A tribute to G. Stanley Hall.

A tribute to G. Stanley Hall.


Fluorescent antibody studies of isolates of Aeromonas salmonicida.


Phospholipid cell-membrane models.

Phospholipid cell-membrane models.


The fixation of pulmonary surfactant for electron microscopy. I. The alveolar surface lining layer.


Changes in the electrical activity of the brain following pinealectomy.


In vitro assay for growth hormone releasing factor (GHRF).


Induction of puberty in immature female rat: effect of estrogen on pituitary FSH and stalk-median-eminence FSH-releasing factor.


Effect of castration or testosterone treatment on hypothalamic FSH-RF and pituitary FSH of male rats.


Diversity of human antibodies to TRIC agents (chlamydiae) detected by different serologic procedures.


Bactericidal effect of hyperbaric oxygen determined by direct exposure.


Stability of pepsin during storage in canine gastric secretions and in aqueous solutions.


Interaction in the germfree mouse intestine of colicinogenic and colicin-sensitive microorganisms.


Retarded immunological recovery in sublethally x-irradiated mice by additional thymic exposure. Reversal with injected marrow cells.


Isoelectric characterization of Clostridium botulnum type C toxin.


The influence of mastitis, local peritonitis and distomatosis on the lymphocytic picture of bovine blood.


Work deprivation as motivation to work.

Work deprivation as motivation to work.


Sociometric status of institutionalized retarded children and nonretarded community children.


The metabolic pathway of glutamate in Escherichia coli K-12.


2,3-dihydroxy-N-benzoylserine: chemical synthesis and comparison with the natural product.


Reactivity of analogues of S-adenosylmethionine in the enzymic synthesis of spermidine by mammalian tissues.


Pulmonary fibroplasia following prolonged artificial ventilation of newborn infants.


Vitamin B12 determination by means of radioisotope dilution and ultrafiltration.


Where are today's pioneering manufacturers of electrocardiographs?


Sequential analysis of variance for medical trials.


Professor de Waard celebrates his seventieth birthday.


Mycotoxins. A possible cause of primary carcinoma of the liver.


Recent contributions in intestinal absorption and malabsorption. A review.


Comparison in normal and leukopenic cows of experimental mastitis due to Aerobacter aerogenes or Escherichia coli endotoxin.


Clinical significance of serum and urinary muramidase activity in leukemia and other hematologic malignancies.


Inclusion bodies in hepatic cytoplasm of dogs and rats after administering endotoxin.


Antilymphocytic serum.

Antilymphocytic serum.


Studies on heterologous antilymphocyte serum in mice. IV. Modifications in the effects of antilymphocyte serum produced by prior adult thymectomy.


The origin of antibody forming cells from lymphocytes.


Bacteriological housekeeping.

Bacteriological housekeeping.


Fluorescent-antibody technique in detection of salmonellae in animal feed and feed ingredients. Comparative studies of fluorescent antibody procedure and a cultural method for the detection of Salmonella were made on 1,013 feed and feed-ingredient samples. The agreement between the two methods was 92.1%. There were more false positives (5.7%) than false negatives (2.2%). Of the 22 false negatives, 15 (68%) were obtained on meat meal. Of the total number of samples, 37% were meat meal. An additional study of 73 samples of meat meal indicated that correlation between methods was better than correlation between samples.


Production of thermostable alkaline proteases by thermophilic Streptomyces. Conditions for the production of thermostable proteases (alkaline proteinase and carboxypeptidase) by a thermophilic streptomycete (Streptomyces rectus var. proteolyticus) were investigated in 20-liter volumes. Proteinase production was affected by the concentration of defatted soybean powder, its optimum being 1.2% in medium containing 2.0% soluble starch. Relatively high concentration of phosphate (0.3 to 0.4% K(2)HPO(4)) was needed for the maximum enzyme production. A large inoculum size (5 to 10%) was favorable, but the inoculum age did not significantly influence the production. The yield increase of 20 to 30% was obtained by feeding of medium during fermentation. The optimal temperature for proteinase production was 50 C, at which the maximal rate of production was 66.2 proteinase units per ml per hr, whereas at 40 C it was 9.0. Production at 50 C reached the maximum within 12 to 16 hr. The optimal agitation rate was different for the production of proteinase and carboxypeptidase, 400 rev/min for the former and 500 rev/min for the latter. The optimal aeration for proteinase production was 20 to 30 liters/min at 400 rev/min, whereas carboxypeptidase production was not markedly affected by aeration rate. The possibility that carboxypeptidase production was correlated with the shear of mycelium was discussed.


Membrane filter-fluorescent-antibody method for detection and enumeration of bacteria in water. A technique which employs nonfluorescing membrane filters and specific fluoresceinisothiocynate-labeled antiserum has been successfully used in the identification and enumeration of known species of Escherichia coli which have been added to natural populations of bacteria found in water. The quantitative results compared favorably with those of standard tests. The use of a dissecting microscope with an external lighting arrangement provided a simple requirement for equipment. This method may be useful in monitoring specific bacterial types from waters which were being monitored for specific pollution.


Potential use of surface-active agents for controlling Mycoplasma contamination in animal cell cultures. Seven nonionic detergents, which were determined to be relatively nontoxic to selected animal cell cultures, were tested for their lethal effect on the GDL strain of Mycoplasma hyorhinis. Of the seven detergents tested, five were found to cause complete lysis of the organism in vitro within 24 hr at 37 C. These detergents included Triton WR-1339 and Tweens 20, 40, 60, and 80. When different concentrations of the detergents were tested, Tween 80 was found to be the most effective and Triton WR-1339 the least effective in lysing the mycoplasmata. These same five detergents were used to treat a rat nephroma cell line which was chronically infected with the GDL strain. The mycoplasmata were eliminated from those cultures treated with Triton but they persisted in cultures exposed to the Tween compounds. The Triton-treated cells remained free from infection over a 7-month period, as determined both by cultural methods and fluorescent-antibody staining. The "cure" was effected by treating the cells for either 48 hr with maintenance media containing 1 mg of Triton per ml or for 96 hr with a concentration of 500 mug/ml. Triton was also effective in eliminating the GDL, strain from experimentally infected rat embryo cells after a 48-hr treatment with a concentration of 1 mg/ml. Four other species of Mycoplasma, which were completely lysed by Triton in vitro, were not eliminated from experimentally infected cells by a single treatment with Triton, although the severity of the infection was apparently reduced.


Significance of hemolytic colonies in throat cultures. These studies indicate that a single strain of hemolytic streptococci almost exclusively predominates the bacterial flora in patients with streptococcal infections and in the carrier state. One can proceed with confidence that, in isolating streptococci from throat swabs cultured on blood-agar plates, only a single hemolytic colony need be picked for serological grouping and typing.


Simple medium for pigment production by the erythrasma diphtheroid. A simple method for the isolation and identification of the causative diphtheroid of erythrasma, Corynebacterium minutissimum, utilizes Muiller-Hinton Agar.


Selective malabsorption of vitamin B12.

Selective malabsorption of vitamin B12.


Tissue transport defects of dibasic amino acids.


Digestion and absorption of fats.

Digestion and absorption of fats.


Amino acid transport: factors influencing uptake in kidney and intestine.


Transcription on an RNA polymerase-DNA complex from E. coli: evidence for in vitro synthesis of ribosomal RNA.


The degradation of DNA by hydrazine: a critical study of the suitability of the reaction for the quantitative determination of purine nucleotide sequences.


Clinical trial of emepronium bromide in nocturnal frequency of old age. A double-blind cross-over trial of emepronium bromide (Cetiprin) in nocturnal frequency of micturition in a group of elderly women living in their homes showed that the drug was superior to placebo in diminishing urinary frequency, though not every person benefited. It is suggested that the drug may alter the established habit of rising at night to pass urine. Side-effects were negligible.


Pancreatic transplantation.

Pancreatic transplantation.


Acute infective gastroenteritis.

Acute infective gastroenteritis.


Effect of propranolol on exercise tolerance of patients with atrial fibrillation. Six patients with atrial fibrillation who were taking digitalis were exercised before and after 30 mg. of propranolol twice daily. Though there was a lower pulse rate at rest and on exercise in all patients, three suffered deterioration of exercise tolerance. It is concluded that propranolol does not improve the exercise tolerance of patients with atrial fibrillation whose resting ventricular rate is controlled with digitalis.


Controlled comparison of the bronchodilator effects of three beta-adrenergic stimulant drugs administered by inhalation to patients with asthma. In a double-blind trial of the effect of inhaling three different beta-adrenergic stimulants (isoprenaline sulphate 1,000 mug., orciprenaline sulphate 1,500 mug., and salbutamol 200 mug.) and a placebo on ventilatory function in 24 patients with chronic asthma salbutamol was found to have a much longer action than isoprenaline, and it produced a slightly more intense and prolonged effect than orciprenaline. In a double-blind subjective assessment 13 of the 24 patients selected salbutamol as the most effective preparation, while only five preferred isoprenaline and three orciprenaline. Hence salbutamol, given by inhalation, may prove to be the most effective drug at present available for the short-term relief of asthmatic symptoms.


Support for the free-end saddle partial denture.


Stem cell renewal in frozen marrow.

Stem cell renewal in frozen marrow.


Differential susceptibility of epithelial cells and fibroblasts of human skin to freeze injury. Report on an improved method for storage of human skin at--196 degrees-C.


Wilson Stuart Stone. October 6, 1907--February 28, 1968.


Dehydration of penicillin-G mycelium by chemical reagents. 3. (a) Relation between viscosity and settling rate of the neat broth and (b) effect of sodium ion on the extraction of penicillin-G from the broth by filtration.


Dark recovery processes in Escherichia coli irradiated with ultraviolet light. II. Effect of uvr genes on liquid holding recovery. The uvr mutations of Escherichia coli K-12 decrease the ability of cells to survive ultraviolet light (UV), to excise pyrimidine dimers from their deoxyribonucleic acid and to reactivate bacteriophage exposed to UV. The rec mutations decrease the ability of the cells to survive UV and to undergo genetic recombination. Certain rec mutations, including recA1, rec-12, recA13, and rec-56, are necessary for the expression of liquid-holding recovery (LHR), observed as an increase in colony-forming ability when irradiated cells are held in buffer in the dark. These rec mutations appear to act indirectly to permit the detection of LHR rather than to affect its occurrence directly. We have tested the effect of uvr markers on LHR in cells containing one of these rec mutations. Recombinants containing rec-56 together with a uvr marker were constructed and tested for LHR. None of the 39 recombinants examined, carrying uvrA6, uvrB5, or uvrC34, showed LHR. Three rec(-)uvr(-) strains were also tested for photoreactivation. In all three, photoreactivation was observed, indicating that they contained detectable amounts of pyrimidine dimers. Our results are consistent with the idea that uvr mutations inactivate LHR, and suggest that LHR reflects excision-dependent repair of pyrimidine dimers.


Hepatotoxicity of erythromycin.

Hepatotoxicity of erythromycin.


Squibb Award. Infectious Diseases Society of America Squibb Award for general excellence in the field of infectious diseases awarded to Robert A. Good, M.D. at the Sixth Meeting of the Society in New York, New York, October 24, 1968.


Deconjugation of bile acids by intestinal bacteria: review of literature and additional studies.


A study of the renal vascular patterns in hypertension and chronic pyelonephritis.


Reflux and pyelonephritis in 35 adults.

Reflux and pyelonephritis in 35 adults.


Urinary tract infection and renal homotransplantation. II. Post-transplantation bacterial invasion.


Experience with silicone rubber-coated foley urethral catheters.


The ureter in renal transplantation.

The ureter in renal transplantation.


The evaluation of quantitative bacterial cultures of urine: growth rate of contaminants.


Histologic demonstration of fat emboli in aseptic necrosis associated with hypercortisonism.


Coexisting Addison's disease and diabetes mellitus: report of 24 cases with review of literature.


Symposium on rehabilitation. Foreword.

Symposium on rehabilitation. Foreword.


The birth defect and the pediatric problems it presents.


Neurosurgical management of patients with spina bifida and myelomeningocele.


Urologic management of children with myelomeningocele.


Orthopedic and habilitation management of patients with spina bifida and myelomeningocele.


Viral flora of chick and duck tissue sources--discussion.


Blood group antigens in virus vaccines.

Blood group antigens in virus vaccines.


Neoplastic properties of animal cell lines. Methods for determining neoplastic properties.


Neoplastic properties of animal cell lines--general comments.


Viral oncogenicity and viral vaccines--general comments.


Charles A. Wilkie.

Charles A. Wilkie.


Cells, vaccines, and the pursuit of precedent.


Uniform compliance with the conditions of participation: does it exist? 1. A look at the loopholes.


Uniform compliance with the conditions of participation: does it exist? 2. How type of control affects compliance.


Chronic depression and drug addiction treated by stereotactic surgery.


Stereotactic tractotomy theatre routine.


An introduction to some concepts of molecular biology.


The limitations of safety testing.

The limitations of safety testing.


The correlation of experimental carcinogenesis and cancer in man.


The metabolic activation of carcinogenic aromatic amines and amides.


Accelerated carcinogen testing.

Accelerated carcinogen testing.


Experimental respiratory tract carcinogenesis.


Modifiers of carcinogenesis.

Modifiers of carcinogenesis.


The specificity of molecular hybridization in relation to studies on higher organisms.


Optical rotatory dispersion and circular dichroism of nucleic acids.


Polarographic techniques in nucleic acid research.


RNA polymerase and the control of RNA synthesis.


The running suture in cataract surgery.

The running suture in cataract surgery.


Editorial: the haemolytic anaemias--a brief review of recent advances.


Three versus five corneoscleral sutures: a comparison of complications and results in 400 cataract operations.


Epiblepharon.

Epiblepharon.


John Milton McLean, M.D.

John Milton McLean, M.D.


Aqueous humor assays of subconjunctival antibiotics.


Aspects of comprehensive medicine.

Aspects of comprehensive medicine.


Experimental ophthalmic surgery employing cyanoacrylate adhesives.


Arterio-venous shunts of the kidney.

Arterio-venous shunts of the kidney.


The role of oxygen in retrolental fibroplasia.


Adrenergic neurone blocking agents: effects and site of action.


Effect of a single neonatal glycocorticoid injection on the thymus-lymphatic and endocrine system and on the growth of the rat and the dog.


The treatment of ascites and esophageal varices.


Current clinical results of renal transplantation.


Immunological mechanisms of allograft rejection.


Modification of renal allograft rejection in man.


The preoperative assessment of histocompatibility.


Selection of recipients and donors for renal transplantation.


Current problems in the delivery of dialysis and renal transplantation.


Late medical complications of renal transplantation.


Caclium, phosphorus, and bone in renal disease and transplantation.


Conjugation in Escherichia coli K-12 and its modification by irradiation. The steps of normal bacterial conjugation (union, transfer, integration and segregation) are described in analytical terms. Only two parameters are utilized: nu(mt) (0), the probability of interruption of transfer of the male chromosome per unit chromosomal distance; and nu(r) (0), the probability per unit chromosomal distance of a recombinational event. Experimentally these two parameters have the same value (0.06 min(-1) or 10(-6) per nucleotide pair). Irradiation of the donor parent prior to mating increases the transfer parameter (nu(mt) = nu(mt) (0) + sigma(mt)D) and a complete description of the radiation response of recombinant production is obtained by a consideration of the single parameter sigma(mt). Irradiation of the recipient parent prior to mating increases the recombination parameter (nu(r) = nu(r) (0) + sigma(r)D) and a complete description of the radiation response of recombinant production is obtained by the addition of the parameter sigma(r). Experimentally sigma(mt) and sigma(r) are found to have the same value, approximately 0.004 krad(-1) min(-1) for X-irradiation. It is thus possible to describe mathematically the behavior of the unperturbed mating system by a single parameter nu(0); a single additional parameter sigma is adequate to describe the behavior of the system when either parental type is irradiated prior to mating. The unexpected observation that nu(mt) and nu(r) have the same value suggests that common molecular mechanisms are involved in the transfer and integration steps.


Mechanisms of inhibition of pyrimidine dimer formation in deoxyribonucleic acid by acridine dyes. The ultraviolet (UV)-induced formation of cyclobutyl pyrimidine dimers in Escherichia coli deoxyribonucleic acid (DNA) in vitro has been investigated in terms of the mechanism of inhibition by acridine dyes, the effect on dimer yield of specific singlet and triplet quenchers, and the mechanism of dimer formation. Our results indicate that (a) energy transfer is important in dimer reduction by acridines, (b) this transfer occurs from the singlet (S(1)) of DNA, and (c) at room temperature triplet quenchers do not reduce dimer yield in DNA.


Changes in arterial oxygenation and physiological deadspace under anaesthesia.


The effect of varying inspiratory gas flow rate.


Anencephaly and spina bifida in the Province of Quebec.


Propranolol in the prophylactic treatment of angina pectoris.


Dr. Thomas John Speakman.

Dr. Thomas John Speakman.


Surgical correction of congenital mitral insufficiency.


Hypersensitivity bronchopulmonary aspergillosis.


Bacterial pneumonia or pulmonary infarction?


Non-replication of dna in heterochromatin of the ovary nurse cells of sciarids.


Observations on nuclear rotation and oscillation in Chinese hamster germinal cells in vitro.


The protection of proteolytic enzymes in aqueous suspension, from inactivation by gastric juice.


A global survey of psychosomatic medicine.


Learning theory and psychoanalysis.

Learning theory and psychoanalysis.


Too little and too late.

Too little and too late.


Some empirical and conceptual bases for coordinated research in psychotherapy: a critical review of issues, trends, and evidence.


Health maintenance in older adults.

Health maintenance in older adults.


A sampling of attitudes toward aging.

A sampling of attitudes toward aging.


Optical rotatory dispersion and circulation dichroism of pepsinogen, carbamylpepsinogen, and succinylpepsinogen.


Dual influx model of thiogalactoside accumulation in Escherichia coli.


Aspartate transcarbamylase. Kinetic studies of the catalytic subunit.


Aspartate transcarbamylase. Studies of the catalytic subunit by ultraviolet difference spectroscopy.


William Smith v. William Harvey. The revealing story of a law court case.


Studies on the interaction between regulatory enzymes and effectors. 3. Crystallization and characterization of adenosine 5'-monophosphate-dependent threonine deaminase from Escherichia coli.


The Freiberg period of the Freud family.


[John George F. Wurdmann (1810-49), a forgotten southern physician-naturalist].


Rigoni-Stern and medical statistics. A nineteenth-century approach to cancer research.


Visit to the Hospital: woodcut by Käthe Kollwitz (ca. 1928) New Haven, Yale Medical Library, Clements C. Fry Collection.


Stereotaxic midbrain lesions for central dysesthesia and phantom pain. Preliminary report.


Successful removal of intracranial air-gun bullet with stereotaxic apparatus.


Cure of tremulous writer's cramp by stereotaxic thalamotomy. Case report.


Focal brain suppression by means of a silicone rubber chemode. Technical note.


Harold Dundonald Macky Hercus.

Harold Dundonald Macky Hercus.


Reticulum cell sarcoma of the stomach.

Reticulum cell sarcoma of the stomach.


Carphenazine in the treatment of schizophrenic psychoses. Controlled clinical trial.


NC 123 in neuroses with depressive and anxiety symptomatology.


The longitudinal EEG study during pharmacotherapy.


Psychotropic effect of mescaline-like drugs.


Comparative study of melitracene and amitriptyline in depressive patients.


Clinical experience with a new antidepressive drug--T.P.D.6. Preliminary report.


E-250 and E-1-250: a clinical comparison of new-type antidepressants.


Clopenthixol in schizophrenia. Comparison of two groups of patients treated by the same drug.


Premedication with ataractics and barbiturates in anxious patients prior to dental surgery.


Learning and memory of chronic alcoholics influenced cholinotropic drugs.


Perathiepine in psychiatry: search for its indications.


Oxypertine in the treatment of schizophrenia.


New York Dermatological Society 1869 to 1969. The fountainhead of dermatology in the Americas.


Henry Daggett Bulkley, 1804 to 1872. Pioneer American dermatologist.


Jonathan Hutchinson on vaccination syphilis.


Archives of dermatology. A genealogical report.


George Morris Lewis, MD 1899 to 1966. In memoriam.


Frank E. Cormia, MD 1905-1968. In memoriam.


The immunofluorescent tumor imprint technique. IV. The significance of "thready" nuclear immunofluorescence.


The influence of some physico-chemical factors on the biliary excretion of a series of structurally related aryl sulphate esters.


Inhibition of bacterial macromolecular syntheses by the polyamine POX-3.


The mode of excretion and metabolic fate of potassium naphthyl 2-35S-sulphate and potassium 5,6,7,8-tetrahydronaphthyl 2-35S-sulphate.


Reaction of disulfides with mercuric ions.


The occurrence and metabolism of 20 alpha-hydroxycholesterol in bovine adrenal preparations.


The reconstitution of infective bacteriophage Q beta.


Subunit structure of the B component of Escherichia coli tryptophan synthetase.


Dysthyroid eye disease. A trial of guanethidine eye drops.


A comparison between whole-thickness skin-graft and Bassini methods of repair of inguinal hernia in men.


Experimental ulcers in closed gastric pouches.


A clinical trial of 'tubigrip' to prevent deep venous thrombosis.


Study of the blood-supply of skin-flaps by close-up thermography.


Pedicled skin-flaps--the fallacy of the length: width ratio.


Effects of atropine and vagotomy on pentagastrin-stimulated gastric acid and pepsin secretion in man.


The mechanism by which pentagastrin stimulates gastric acid secretion.


The effect of measuring uncollected secretion upon the gastric pepsin-acid response to histamine and pentagastrin.


A horse anti-human lymphocytic serum for clinical trial in renal homo-transplantation.


Calcitonin in blood.

Calcitonin in blood.


Effects of ionizing radiation on the matrix of bone implants.


Autologous bone marrow grafts in dogs treated with lethal doses of cyclophosphamide.


The susceptibility of fetal rat skin in different immunologic environments to neoplastic induction with Shope papilloma virus.


Influence of hypothalamic lesions on the induction and growth of mammary cancers in Sprague-Dawley rats receiving 7,12-dimethylbenz(a)anthracene.


Sickle cell anaemia.

Sickle cell anaemia.


Variability of response in the bioassay for a hypothalamic somatotrophin releasing factor based on rat pituitary growth hormone content.


Inhibition of the in vitro secretion of insulin by an extract of pancreatic alpha-1 cells.


Elevation of plasma LH concentrations induced by LH-releasing factor as measured by radioimmunoassay in the sheep.


Influence of cell disruption methods on polyuridylic acid dependent polyphenylalanine synthesis by isolated ribosomes of mycobacteria.


Fixation for electron microscopy and the retention of 3H-noradrenaline by tissues.


Immunofluorescent technique and long acting thyroid stimulator in human serum.


Immunosuppressive and specific antimitotic effects of ovalicin.


Fluorescence assay of tyrosine hydroxylase activity in tissue homogenate.


Effect of low dosage of carbenoxolone sodium on gastric ulcer healing and acid secretion.


Role of gastric secretion in iron absorption.


Approaches to the mental health manpower problem. A review of the literature.


Attitudes toward mental patients. A review of empirical research.


Organization of information about micro-organisms.


Mycotoxins.

Mycotoxins.


Microbiological transformations of sugars and related compounds.


Production of polyhydric alcohols by yeasts.


The effects of newer forms of packaging on the microbiology and storage life of meats, poultry and fish.


Artefactitious extravasation of fluorescent indicators in the investigation of vascular permeability in brain and spinal cord.


Ultrastructural features of Chang human liver cells in media of low glucose content. A comparison with HeLa cells cultivated under similar conditions.


Bacterial counts in urine. 1. The reliability of the loop technique.


A new species, Sphaerophorus intermedius, isolated from empyema.


Ultrastructural demonstration of lysosomes in Toxoplasma gondii.


A controlled study of the blood sugar response to insulin injection in schizophrenia.


Dialysis culture of microorganisms: design, theory, and results.


The significance of ribokinase for ribose utilization by Escherichia coli.


The effect of animal sera and bovine serum albumin on L-asparaginase determination in vitro.


Phycomyces.

Phycomyces.


The effect of streptomycin on the synthesis of proline in Escherichia coli.


Radiosensitisation of bacterial and mammalian cells with carbonyl compounds, with special reference to the properties of phenylglyoxal.


Sporulation and the production of antibiotics, exoenzymes, and exotonins.


Molecular aspects of endotoxic reactions.


The methionine-repressible homoserine dehydrogenase and aspartokinase activities of Escherichia coli K 12. Preparation of the homogeneous protein catalyzing the two activities. Molecular weight of the native enzyme and of its subunits.


Incorporation and phosphorylation of 5-azacytidine by normal and T4-phage-infected cells of E. coli.


Some properties of 30S and 50S particles formed in the absence of protein synthesis by phosphorus-starved Escherichia coli.


Immunological investigations in experimental chemotherapy. 3. The initial period of low resistance in bacterial infections of mice in relation to bacteriostatic chemotherapy.


Studies on the Escherichia coli Methionine transfer ribonucleic acids.


The conversion of [14C]cycloartenol and [14C)lanosterol into phytosterols by cultures of Nicotiana tabacum.


Phosphoryl transfer from S-substituted monoesters of phosphorothioic acid to various acceptors catalyzed by alkaline phosphatase from Escherichia coli.


Purification and properties of N-acetylmannosamine kinase from Salmonella typhimurium.


The nucleotide sequence of N-formyl-methionyl-transfer RNA. Partial digestion with pancreatic and T-1 ribonuclease and derivation of the total primary structure.


Bactericidal substances in cytoplasm of leucocytes. An attempt to separate lysozyme by gel filtration.


The phagocytic activity of reticuloendothelial system of newborn precolostral pigs to smooth and rough Escherichia coli.


Enteropathogenic Escherichia coli serotypes found in sewage lagoons (waste stabilization ponds) in North Dakota.


Melioidosis-laboratory studies.

Melioidosis-laboratory studies.


Earle Kirkpatrick Borman.

Earle Kirkpatrick Borman.


Methods for early diagnosis of oral tumors: Cytology.


Reaction of the oral neuromuscular structures to the insetion of prosthetic appliances.


Electrochemical processes in oral tissues.


Stereotaxic cryothalamectomy in a unique unit.


Surgeon in Obermenzing 7.

Surgeon in Obermenzing 7.


Renal tubular acidosis, acidosis due to hyperkalaemia, hypercalcaemia, disordered citrate metabolism and other tubular dysfunctions following human renal transplantation.


Neurosurgery in childhood.

Neurosurgery in childhood.


Fortinbras and Hamlet.

Fortinbras and Hamlet.


Cellular regulation of glutamine synthetase activity in Escherichia coli.


Coriolanus: the anxious bridegroom.

Coriolanus: the anxious bridegroom.


Macbeth: "fair is foul and foul is fair".


Iago.

Iago.


Othello's jealousy.

Othello's jealousy.


Fluorometric assay of enzymatic reactions involving acetyl Coenzyme A in aldol condensations.


Analysis of sugars in bacterial endotoxins by gas-liquid chromatography.


Thin-layer and gas chromatographic deterimination of alpha, epsilon- diaminopimelic acid in Escherichia coli.


Batch procedure for thermal elution of DNA from hydroxyapatite.


Central nervous system malformation stillbirths, maternal age and birth order.


Personality.

Personality.


Editorial: retirement of C. van Staveren from the surgical department of Dijkzigt Municipal Hospital in Rotterdam.


Some considerations regarding subcutaneous rupture of the tendo Achillis.


Transferable drug resistance.

Transferable drug resistance.


Transferable drug resistance in enterobacteria isolated from urban infants. Antibiotic-resistant enterobacteria, the vast majority of which carried transmissible R factors, were isolated from 81 out of a total of 100 healthy infants. There was surprisingly little correlation between previous antibacterial therapy and the resistant enterobacterial flora.


Rare complication of tracheostomy: erosion of innominate artery.


Sir Sydney A. Smith.

Sir Sydney A. Smith.


Clinical trial of lincomycin hydrochloride in Reiter's disease. A double-blind trial comparing lincomycin hydrochloride (Mycivin) and placebo in 22 patients with Reiter's disease showed no significant difference in clinical or laboratory findings between the two groups. It is concluded that lincomycin hydrochloride is no more effective than placebo in the treatment of Reiter's disease.


The activity of lysozyme: an interim review of crystallographic and chemical evidence.


Fifty years of federal health.

Fifty years of federal health.


Psychotherapy: what, how and why?

Psychotherapy: what, how and why?


Endotoxins and the immune response.

Endotoxins and the immune response.


Climatology and medicine. I.

Climatology and medicine. I.


The rubella problem.

The rubella problem.


Cordilox up to date.

Cordilox up to date.


Corticosteroid therapy in glandular fever.


A non-dialyzable inhibitor of proteolytic activity in soluble extracts of Escherichia coli.


Brain uptake of 3H noradrenaline in normal and Shigella dysenteriae exotoxin treated mice.


The role of the bacterial cell wall in the development of the lethal effect of colicin E1.


Separation of T-even bacteriophage deoxyribonucleic acid from host deoxyribonucleic acid by hydroxyapatite chromatography. A simple and rapid method is described for separation of T-even bacteriophage deoxyribonucleic acid (DNA) from host (Escherichia coli) DNA by hydroxyapatite column chromatography with a shallow gradient of phosphate buffer at neutral pH. By this method, bacteriophage T2, T4, and T6 DNA (but not T5, T7, or lambda DNA) could be separated from host E. coli DNA. It was found that glucosylation of the T-even phage DNA is an important factor in separation.


Oxidation D-malic and beta-alkylmalic acids wild-type and mutant strains of Salmonella typhimurium and by Aerobacter aerogenes. A mutant strain of Salmonella typhimurium (SL 1634 dml-51) capable of growth on d-malate as sole carbon source was shown to produce d-malic enzyme. This enzyme was absent in the parent wild-type strain which was unable to grow on d-malate. Growth of the mutant on d-malate also resulted in a greatly increased level of beta-isopropylmalic enzyme compared with its level in the wild-type strain grown on citrate or l-malate. The d-malic and beta-isopropylmalic enzymes, both of which catalyze a nicotinamide adenine dinucleotide- and Mg(++)-dependent oxidative decarboxylation of their respective substrates, were shown to be distinct enzymes by selective inhibition with erythro-dl-beta-hydroxyaspartate and by other methods. Cell extracts of the mutant strain also oxidized dl-beta-methyl-, dl-beta-ethyl-, dl-beta-propyl- and dl-betabeta-dimethylmalates, in order of decreasing activity. dl-beta-Methyl-malate was shown to be oxidized by both the d-malic and the beta-isopropylmalic enzymes, whereas the oxidation of the other beta-alkylmalates appeared to be effected exclusively by the beta-isopropylmalic enzyme. beta-Isopropylmalic enzyme activity was induced by d-malate but not by l-malate, showing that it behaved as a d-malictype enzyme. Growth of Aerobacter aerogenes on d-malate, which caused induction of d malic enzyme, resulted in only a small increase in the activity of beta-isopropylmalic enzyme.


Cell wall growth during differentiation of Proteus swarmers. This paper describes the process by which the cell wall of Proteus mirabilis, as measured by the presence of the O antigen, develops during the differentiation of swarmers from short cells on an agar surface. The sequence was followed by fluorescent-antibody staining, with both the direct and reverse methods. When the organisms were labeled with fluorescent antibody by the direct method, they showed a progressive diminution of the marker along the cell surface and some increase in the length of the bacteria. However, the label had become completely diluted out before typical swarmers developed. When the bacteria were exposed initially to unlabeled antibody by the reverse technique, and then incubated with fluorescent antibody, they showed a progressive increase both in the intensity of the label along their entire periphery and in cellular length, culminating in the formation of swarmers. It is concluded that in P. mirabilis, as in the few other gram-negative bacteria examined so far, cell wall synthesis takes place diffusely, i.e., by intercalation of new with old components along the length of the cell wall.


Analytical studies on regeneration of protoplasts of Geotrichum candidum by quantitative thin-layer-agar plating. A preparation of pure protoplasts of Geotrichum candidum became osmotically stable and colonies developed when the protoplasts were embedded in stabilizing thin-layer-agar and incubated with stabilizing basal medium. When growing protoplasts were exposed to distilled water and then reincubated with basal medium, the process of regeneration of protoplasts could be quantitatively demonstrated by counting colonies. The process was divided into three phases, lag, logarithmic, and stationary. Furthermore, the state of regeneration of protoplasts at each phase could be seen in detail by microscopic studies of protoplasts under similar growth conditions. In the lag phase, which lasted for 2 hr after inoculation, protoplasts were completely destroyed when placed in distilled water. During the logarithmic phase, from 2 to 5 hr after inoculation, protoplasts rapidly became osmotically stable and about 18% of them were growing. In the stationary phase, most protoplasts developed germ tubes within 2 hr. These results suggested that there are two main phases, although individual cells passed through three different conditions, osmotically labile, osmotically stable, and growing. No apparent structure of cell wall material could be detected by electron microscopy on the surface of the membrane of these osmotically stable cells.


Presence of nuclear bodies in some minicells of Escherichia coli. Electron microscopy of serial sections of Escherichia coli K-12 (P678-54) revealed that some "minicells" contain nuclear bodies.


Energy coupling in the transport of beta-galactosides by Escherichia coli: effect of proton conductors. Escherichia coli accumulates thiomethyl-beta-d-galactoside against a concentration gradient under anaerobic conditions. The accumulation was abolished by carbonylcyanide m-chlorophenylhydrazone, tetrachlorosalicylanilide, 2,4 dinitrophenol, and other uncouplers of oxidative phosphorylation even though oxidative phosphorylation would not be expected to occur anaerobically. In the presence of the uncouplers, the beta-galactoside carrier remained functional and catalyzed equilibration of thiomethylgalactoside across the membrane. The uncouplers did not inhibit the generation of adenosine triphosphate or protein turnover, or the accumulation of alpha-methylglucoside and glycerol by phosphorylation. We conclude that, at least anaerobically, uncouplers of oxidative phosphorylation do not interfere with energy metabolism in general, but prevent the utilization of metabolic energy for the active transport of galactosides. The uncouplers also facilitate passage of protons across the membrane. Various hypotheses are considered to explain why a proton-impermeable membrane may be required for active transport of galactosides and other substrates.


Abnormal 30S ribosomal subunits determined by an ochre suppressor mutation in Escherichia coli. The results demonstrate that an ochre suppressor mutant of Escherichia coli K-12 produces abnormal 30S ribosomes. The production of these abnormal 30S ribosomes is probably a secondary consequence of the suppressor mutation.


Technique for screening 2n combinations of nutritional requirements. An auxanographic technique is described, which makes it possible to screen 2(n) combinations of nutrients on relatively few agar plates.


Influence of the fertility episome on the survival of x-irradiated Escherichia coli. The resistance of Escherichia coli to the lethal effects of X rays was increased by the presence of a fertility episome integrated into the chromosome.


Paul Budd Magnuson, M.D., 1884-1968.

Paul Budd Magnuson, M.D., 1884-1968.


George Andrew Duncan, M.D., 1903-1968.

George Andrew Duncan, M.D., 1903-1968.


Medical education at America's first University.


An improved on-line calibrator for dye-dilution curves.


Internal hernia into Treves' Field Pouch: report of two cases and review of literature.


Effectiveness of the xenogeneic and allogeneic components of bivalent rabbit antilymphocyte serum.


Heights and weights of Jamaicans.

Heights and weights of Jamaicans.


Iron deficiency in children in Saudi Arabia.


The use of plasma fractions in the treatment of hemophilia and von Willebrand's disease.


Intracellular pH.

Intracellular pH.


On the mechanism of thrombosis.

On the mechanism of thrombosis.


Intrinsic factor and the other vitamin B12 transport proteins.


Fatty liver, cirrhosis, and metabolic effects related to problem drinking.


Drug and placebo responses in chronic alcoholics.


The interpretation of tracer fluxes in terms of membrane structure.


Factors influencing the polymerization of outer fibre microtubule protein.


Virulence of Escherichia coli isolated from pigs with colibacillosis and from healthy pigs and toxicity of their endotoxins for mice and chick embryos.


The neurosurgical legacy of Harvey Cushing.


Primary melanomas in unusua sites.

Primary melanomas in unusua sites.


Ocular aspects of cervical vascular disease.


Cary Eggleston. 1884-1966.

Cary Eggleston. 1884-1966.


Louis Lowenstein. 1908-1968.

Louis Lowenstein. 1908-1968.


James Howard Means. 1885-1967.

James Howard Means. 1885-1967.


Arnold Rice Rich. 1893-1968.

Arnold Rice Rich. 1893-1968.


Parkinsonism and DOPA.

Parkinsonism and DOPA.


Presentation of the Kober Medal for 1968 to Tinsley Randolph Harrison.


Acceptance of the Kober Medal for 1968.

Acceptance of the Kober Medal for 1968.


Association of American Physicians. Directory.


Vascular lesions of the transplanted human kidney--morphologic and hemodynamic studies in chronic rejection.


Charles Hoyt Burnett. 1913-1967.

Charles Hoyt Burnett. 1913-1967.


Charles Sidney Burwell. 1893-1967.

Charles Sidney Burwell. 1893-1967.


Evidence for central inhibition of retinal function.


Corticosteroid treatment in bronchiolitis. A controlled, collaborative study in 297 infants and children.


Dexamethasone in croup. A controlled study.


Immunosuppressive therapy of ocular inflammatory diseases.


Thiamine uptake in Escherichia coli. I. General properties of thiamine uptake system in Escherichia coli.


An improved tarsorrhaphy technique and its therapeutic applications.


Intrachain disulphide bridges in immunoglobulin G heavy chains. The Fc fragment. The disulphide bridges of the Fc fragment (C-terminal half of the heavy chain) have been studied in several human immunoglobulins, containing heavy chains of different antigenic types (gamma1, gamma2, gamma3 and gamma4), and in heavy-chain-disease proteins. Two intrachain disulphide bridges were found to be present. The sequences appear to be identical in the Fc fragments of two types of chain studied (gamma1 and gamma3), and very similar to corresponding sequences of the Fc fragment in rabbit. These results suggest that the C-terminal half of the heavy chains is covalently folded (in a similar fashion to the light chains) with a C-terminal loop and an N-terminal loop. The similarity is emphasized by comparison of the sequence and location of the disulphide-bridged peptides of the C-terminal loop of heavy and light chains. The N-terminal loop, on the other hand, appears to be very different in Fc fragments and light chains. The C-terminal loop is the only one present in the F'c fragment.


Leucyl-beta-naphthylamide-splitting enzymes in the mammalian endocrine pancreas. The proteolytic capacity of the endocrine pancreas in obese-hyperglycaemic mice was evaluated by using the chromogenic substrate l-leucyl-beta-naphthylamide (LNA). The analytical sensitivity obtained with this substrate in photometric and fluorimetric assays permitted quantitative determinations of C-N-bond-splitting activity in both crude islet homogenates and electrophoretic fractions thereof. The following observations were made: (1) The rate of LNA cleavage was maximal at about pH7 in islets as well as in acinar tissue. An apparent K(m) of 4x10(-5)-6x10(-5)m was calculated for both the endocrine and exocrine pancreas. (2) The level of LNA-splitting enzyme activity was of the same magnitude in the islets as in the liver, and significantly higher in the islets than in the exocrine pancreas. Starving the animals for 7 days did not affect the enzyme activity levels. (3) Two distinct LNA-splitting enzymes could be separated from the pancreatic islets by means of disc electrophoresis, the most rapidly migrating band representing the highest activity. Though similar electrophoresis patterns were obtained with acinar tissue and liver, only one enzyme could be demonstrated in serum. The data suggest that the beta-cells, in addition to being highly specialized for the production of a specific protein, contain a comparatively high capacity for protein catabolism.


The purification of luteinizing-hormone-releasing factor with some observations on its properties. Bullock median-eminence tissue was used as a source of luteinizing-hormone-releasing factor for small-scale experiments to explore methods for its isolation. The presence of luteinizing-hormone-releasing factor was detected by the ovulation response in rabbits after intrapituitary infusion of the extract. Gel filtration was found to be suitable for the purification of these extracts. The releasing factor appeared to be a basic peptide of molecular weight in the range 1200-2500. On a larger scale, an extract of hypothalamic tissue from sheep was used to establish a multi-stage isolation procedure that resulted in a 200000-fold purification of luteinizing-hormone-releasing factor. After the initial extraction the isolation process consisted of: (1) two cycles of gel filtration; (2) anion-exchange chromatography; (3) gel filtration in a partially organic medium; (4) thin-layer chromatography on cellulose. Stage (3) separated two zones of activity each containing peptides. One of these was purified further by stage (4) to give a preparation that was active at a dose of 6mug. of peptide/animal, although activity diminished seriously during storage. This preparation contained only five or six components, but the small amounts of peptides obtained at this stage of purity were insufficient for full characterization.


Biosynthesis of the pyrimidine moiety of thiamine. A new route of pyrimidine biosynthesis involving purine intermediates. 1. The pattern of distribution on the purine pathway of mutants of Salmonella typhimurium LT2 that had the double growth requirement for a purine plus the pyrimidine moiety of thiamine (ath mutants) indicated that purines and the pyrimidine moiety of thiamine share the early part of their biosynthetic pathways, and that 4-aminoimidazole ribonucleotide (AIR) is the last common intermediate. Two mutants that at first appeared anomalous were further investigated and found not to affect this deduction. 2. The ribonucleoside form of AIR (AIR(s)) satisfied the requirements both for a purine and for the pyrimidine moiety of thiamine of an ath mutant. 3. Methionine was required for the conversion of AIR into the pyrimidine moiety. 4. Radioactive AIR(s) was converted into radioactive pyrimidine moiety by an ath mutant without significant dilution of specific radioactivity. 5. Possible mechanisms for pyrimidine-moiety biosynthesis from AIR are discussed.


Precursors of the pyrimidine moiety of thiamine. 1. A method was devised for obtaining the pyrimidine moiety of thiamine in a pure form after its excretion into the medium by de-repressed washed-cell suspensions of mutants of Salmonella typhimurium LT2. 2. By using amino acid-requiring mutants, this excretion of pyrimidine moiety was shown to be dependent on the presence of both methionine and glycine. 3. In the presence of either [Me-(14)C]methionine or [G-(14)C]methionine, methionine-requiring mutants did not incorporate radioactivity into the pyrimidine moiety. 4. In contrast, both [1-(14)C]glycine and [2-(14)C]glycine were incorporated into the pyrimidine moiety excreted by glycine-requiring mutants, and this occurred with little or no dilution of specific radioactivity. 5. The possible requirement for methionine as a cofactor and the significance of the incorporation of both carbon atoms of glycine are discussed.


Immediate fixation using endosseous implants.


Clinico-pathological study on the effect of high-speed cavity preparation on human deciduous teeth.


The preparation and visualization of cell walls of hyphal fungi.


Radiology of serosal malignancy.

Radiology of serosal malignancy.


Tissue preparation vital to the study of micro-anatomy.


Status of federal medical-dental legislation.


A clinical trial of glymidine (Gondafon).


Autoimmune graft rejection.

Autoimmune graft rejection.


Biliary and urinary metabolites of estrone-6,7-3H-sulfate-35S in a woman.


Studies of plasma insulin in myotonic dystrophy.


Enhancement of the anti-inflammatory action of hydrocortisone by estrogen.


Members of the Colorado Dental Association, May, 1969.


Effects of chlordiazepoxide on ESB-reinforced behavior and subsequent extinction.


The use of autogenous bone grafts in the treatment of infrabony periodontal defects.


Upper full denture retention.

Upper full denture retention.


Pathomechanism of haemorrhages following tracheotomy.


SCDA approved unit count systems.

SCDA approved unit count systems.


Dental care programs and dental prepayment plans.


The clinical significance of necrosis of the skin.


The treatment of bronchial asthma.

The treatment of bronchial asthma.


Disseminated intravascular clotting.

Disseminated intravascular clotting.


Treatment of arrhythmias associated with acute myocardial infarction.


The management of acute pulmonary edema.


Hypertensive crisis.

Hypertensive crisis.


The diagnosis of pulmonary embolism.

The diagnosis of pulmonary embolism.


The radiologic spectrum of pulmonary embolic disease.


Obscure gastrointestinal hemorrhage.

Obscure gastrointestinal hemorrhage.


Changing patterns of urogenital tuberculosis.


Medical management of acute pancreatitis.


Diabetic emergencies: drug-induced hypoglycemia.


The influence of extracellular fluid volume on the renal bicarbonate threshold. A study of two children with Lowe's syndrome.


The crane principle for the transport of subcutaneous tissue.


The nasolabial tunnel flap.

The nasolabial tunnel flap.


"Plasmatic circulation" in skin grafts. The phase of serum imbibition.


Water and electrolyte changes in autogenous skin grafts. Discussion of the so-called "plasmatic circulation".


The classic reprint. Ancient ear-lobe and rhinoplastic operations in India.


Eric W. Peet, 1909-1968.

Eric W. Peet, 1909-1968.


Reject gold castings in winter.

Reject gold castings in winter.


Effect of allotransplantation of the canine lung on pulmonary surfactant.


Management of extensor tendon injuries of the hand.


Lymphocytes and surgery.

Lymphocytes and surgery.


Everted intestinal anastomosis.

Everted intestinal anastomosis.


Control of pyrimidine biosynthesis by phage T4: mutants unable to catalyze the reduction of cytidine diphosphate.


Assay of wound tumor virus by the fluorescent cell counting technique.


Virus-induced synchronous division of bacterial cells.


Ring opening of covalent lambda phage DNA circles after thermal induction of superinfected lysogens: control by gene N.


Inert gas measurements of coronary blood flow.


Dr. Sam. V. Setting up practice (Samuel Booth Sturgis).


Studies on cell walls of group A Streptococcus pyogenes, type 12. 1. Mechanism of lysis by the L-11 enzyme and possible structure of a peptide moiety of the peptidoglycan.


"Twenty years a-growing.

"Twenty years a-growing.


Experimental and clinical studies on x-ray irradiated mandibular bone grafts.


Fifty years of health protection in Poland.


Analog and digital storage of radioisotope indicator concentration data on FM analog magnetic tape.


Turbidimetric microbiological assay of antibiotics using an automatic analyzer.


Yamagiwa's tar cancer and its historical significance. From Percival Pott to Katsusaburo Yamagiwa.


The treatment of gonorrhoea with doxycycline as a single dose.


Changes in ultraviolet absorption produced by alteration of protein conformation.


The lysozyme of bacteriophage lambda. I. Purification and molecular weight.


The lysozyme of bacteriophage lambda. 3. Ordering the cyanogen bromide peptides.


Immunological prediction of sequence differences among proteins. Chemical comparison of chicken, quail, and phesant lysozymes.


Genetic blocks and unique features in the biosynthesis of 5'-phosphoribosyl-N-formylglycinamide in Salmonella typhimurium.


The enzymes of the galactose operon in Escherichia coli. 3. The size and composition of galactokinase.


The enzymes of the galactose operon in Escherichia coli. IV. The frequencies of translation of the terminal cistrons in the operon.


The control of ribonucleic acid synthesis in Escherichia coli. II. Stringent control of energy metabolism.


Biochemical and genetic studies with lysine+methionine mutants of Escherichia coli: lipoic acid and alpha-ketoglutarate dehydrogenase-less mutants.


Radiation-protective agents in mammals.

Radiation-protective agents in mammals.


Effect of hydroxyurea on replication of bacteriophage T4 in Escherichia coli. Hydroxyurea inhibited the replication of bacteriophage T4 in Escherichia coli B. The concentration of hydroxyurea required to inhibit net deoxyribonucleic acid (DNA) synthesis 50% was about 50-fold less than that required in uninfected cells. Even in the presence of high hydroxyurea concentrations, phage DNA was readily synthesized from the products of breakdown of the E. coli DNA, and viable phage were made. Deoxyribonucleotide, but not ribonucleotide, synthesis was strongly inhibited in the presence of hydroxyurea. The data indicate that hydroxyurea specifically inhibits de novo DNA synthesis in E. coli infected with bacteriophage T4 by inhibiting the ribonucleoside diphosphate reductase system, but does not affect DNA synthesis at subsequent steps.


Loss of lysis inhibition in filamentous Escherichia coli infected with wild-type bacteriophage T4. The plaque enlargement of wild-type T4 bacteriophage observed when assayed in the presence of low concentrations of mitomycin C or after exposure to very low doses of ultraviolet light was studied by using solid as well as liquid culture media. It was found that the filamentous cell formed by the treatment with the agents is responsible for the phenomenon. The filamentous cell was also shown to be characterized not only by the loss of capacity of lysis inhibition but also by a shortening of the latent period. No difference in cellular rigidity could be seen between the filamentous cell and normal cell as far as the analysis from the outside of the cell was concerned, whereas the former cell was shown to be more readily susceptible to phage-induced lysozyme from the inside of the cell. A possible change in the membrane of the filamentous cell and a possible mechanism for lysis inhibition are discussed.


Solutions to some problems in food bacteriology.


Clinical studies with a new rifamycin derivative.


Isolation of bacteriophage for Clostridium tetani. The purpose of this report is to note the isolation of a Clostridium tetani phage from soil and to specify the procedure used to obtain suitable lawns for plaque formation.


Herman Boerhaave: the Dutch Hippocrates.


Double-blind trial of anorectic agents.

Double-blind trial of anorectic agents.


Placebo response in the evaluation of hypnotic drugs.


The history of Royal Children's Hospital, Brisbane.


Recommendations of the N.H.M.R.C. regarding organ transplants.


Dr. John Singleton.

Dr. John Singleton.


Fine and coarse controls of genetic recombination.


Transfer of a neomycin-kanamycin resistance determinant by the F factor of Escherichia coli K12.


Tubular transport by human kidney stored at 4 degrees C.


Clinical value of the indocyanine green test in the diagnosis of chronic liver diseases.


Physical activity after myocardial infarction--changing concepts.


The laser and its biomedical application.


Nonunion of the carpal navicular: analysis of 42 cases treated by the Russe procedure.


Immunofluorescence studies of a lymphoid cell line derived from a patient with lymphocytic lymphoma.


The history of goiter in Bolivia, Paraguay and Brazil.


Recent issues in nursing manpower: a review.


The thymus gland and immunity.

The thymus gland and immunity.


The treatment of enuresis: a controlled clinical trial of propantheline, propantheline-and-phenobarbitone and a placebo.


Light driven scattering changes and increased 515 nm absorbance changes associated with fatty acid inhibition of photosynthesis in Chlorella.


A controlled trial of imipramine ('Tofranil') and nortriptyline ('Allegron') in the treatment of enuresis.


Sarah G. Mayer, 1893-1968.

Sarah G. Mayer, 1893-1968.


Clinical trial of a new B-adrenergic stimulant in asthma.


The management of burns. I. General considerations and the sulfamylon method.


Immune responses and the gut.

Immune responses and the gut.


Clinical trial of deglycyrrhizinized liquorice in gastric ulcer.


Peptic activity after the administration of Pentagastrin and in gastroduodenal disease.


Bilirubin metabolism.

Bilirubin metabolism.


A model of criteria for evaluating progress in children undergoing psychotherapy.


Ulcerative colitis in children. Current views and therapies.


Childhood asthma and the social milieu.

Childhood asthma and the social milieu.


Activity vector analysis vs. clinical appraisal in personality description.


[Some comments about Ingmar Bergman's The Silence and its sociocultural implications].


The evolution of medical education in the United States of America.


Target physiologic corroboration in stereotaxic cervical cordotomy.


Evoked response audiometry: some considerations.


Physiologic evaluation of allogeneic canine lung transplants from living donors.


A fluorescence microscopic study of bile duct proliferation induced in guinea pigs by alpha-naphthyl isothiocyanate.


Isotopic determination of intestinal calcium absorption in normal subjects.


Platelet function (first of three parts).


Hospital outbreak of infections with group a streptococci traced to an asymptomatic anal carrier.


Anticoagulants in myocardial infarction.


Method, findings, and theory in studies of visual masking.


Survey of electromechanical devices for behavior modification.


Comparison of strategies in developing scales for dominance.


Modification of smoking behavior: a review.


Explanations of geometrical illusions.

Explanations of geometrical illusions.


Interpreting perceptual reports.

Interpreting perceptual reports.


Current methodology in research on the etiology of schizophrenia: serious difficulties which suggest the use of the high-risk-group method.


Grief: its nature and significance.

Grief: its nature and significance.


Chemoprophylaxis of pulmonary tuberculosis.


Intersomatic fusion with calf bone "Kiel bone splint" in the anterior surgical approaach for the treatment of myelopathy in cervical spondylosis.


Stereotaxic treatment of patients with parkinson's disease.


Some projective techniques in hypnotherapy: induction of dreams and real versus hallucinated sensory hypnoplasty.


Immunocytologic study of nasal epithelial cells in influenza.


Formaldehyde: a photothermal activated toxic substance produced in Middlebrook 7H10 medium.


Mitral stenosis.

Mitral stenosis.


Pulmonic stenosis.

Pulmonic stenosis.


The maintenance of function of the donor heart in the extracorporeal stage and during transplantation.


Paul W. Sanger in memoriam.

Paul W. Sanger in memoriam.


The facial outflow and the superior salivatory nucleus: an histochemical study in the rat.


Gaspare Tagliacozzi--plastic surgeon.

Gaspare Tagliacozzi--plastic surgeon.


A double-blind comparative trial of dibenzepin and imipramine.


Clinical and laboratory study of a new diuretic agent ("vectren") in pregnancy: a comparison with a diuretic agent in current use ("enduron").


Army war surgery in Vietnam.

Army war surgery in Vietnam.


Homo- and hypersexuality in rats with hypothalamic lesions.


Data on the location of the neural structures indispensable for the occurrence of ovarian compensatory hypertrophy.


Causes of death in cadaveric kidney donors. An analysis of 20 post-mortem medico-legal examinations.


Effects of suckling on pituitary release of prolactin, GH, and TSH in postpartum lactating rats.


Effects of isolation of the hypothalamo-pituitary unit in newborn guinea pigs.


The distribution and control of osmosensitive cells within the hypothalamus of the opossum (Didelphis virginiana).


Oliver St. John Gogarty, M.D. (1878-1957). Buck Mulligan of Irish Renaissance.


Annual Oration, 1968. Introduction of orator, Eugene L. Saenger, M.D.


A comparative study of periosteal new-bone response in metastatic bone tumors (solitary) and primary sarcomas.


Angiographic evaluation of the human homotransplant kidney.


The pontomesencephalic veins. A roentgenographic study.


Glucose-6-phosphate dehydrogenase deficient red cells: resistance to infection by malarial parasites. Erythrocyte mosaicism occurs in females heterozygous for glucose-6-phosphate dehydrogenase deficiency. In blood from female children with acute Plasmodium falciparum malaria the parasite rate was 2 to 80 times higher in normal than in deficient erythrocytes. This may be the mechanism whereby the gene for glucose-6-phosphate dehydrogenase deficiency confers selective advantage against malaria to heterozygous females, and thus may have attained the polymorphic frequency occurring in populations living in areas with endemic malaria.


Ocular refraction at low illuminations.

Ocular refraction at low illuminations.


A selected public health bibliography with annotations.


Fluorescence microscopy of the spinal cord of the dog, with special reference to the autonomic lateral horn cells.


In honor of Dr. Joseph Elias Milgram.

In honor of Dr. Joseph Elias Milgram.


An historical perspective of double hands and double feet. The survey of the cases reported in the 16th and 17th centuries.


Exocrine and endocrine functions of the allografted pancreas.


Diastematomyelia.

Diastematomyelia.


The content of plasminogen-activator in the endometrium, estimated by the fibrin-agar plate method.


Distribution of Toxoplasma gondii, Beverley strain, in infected mice as determined by the fluorescent antibody technique and the histopathology of toxoplasmosis.


Renal hemodynamics during selective renal angiography.


An immunohistochemical study of estrogen-induced pituitary adenoma in rat.


An evaluation of intermittent positive pressure breathing in the prevention of postoperative pulmonary complications.


Dextran 75 and postoperative phlebitis. Evaluation of dextran 75 in the prophylaxis of postoperative thrombophlebitis, pulmonary embolism, and myocardial infarction.


Auxiliary partial liver transplantation in the dog.


Skin allograft survival in calves. Influence of thymectomy and extracorporeal irradiation of blood.


Antiprotozoan activity of nitroimidazoles.


Sudden cardiac death of pilots in flight. With special consideration of syncope due to silent ischemic heart disease and the differential diagnosis of other causes of episodes of incapacitation, unconsciousness, confusion and amnesia in flying personnel.


Graft versus host inhibition. I. Incubated parental strain spleen and liver cells administered to F1 mice.


Structural changes in the area striata of the mouse after enucleation.


Studies on the chicken immune response. 3. Cellular and humoral antibody production in the splenectomized chicken.


A comparison of seven procedures to detect the primary binding of antigen by antibody.


Studies on heterologous antilymphocyte and antithymocyte sera. 3. Differential effects of rabbit anti-mouse sera on splenic lymphocytes and macrophages.


Wasting disease induced with cortisol acetate. 3. Immunologic studies.


Antigenicity of the M proteins of group A hemolytic streptococci. V. The absence of antigenic determinants common to mammalian heart muscle.


A comparative trial of imipramine and phenobarbital in depressed patients seen in general practice.


On the diaphragm across fenestrae of capillary endothelium.


Caspar Wistar (1761-1818), Philadelphia anatomist.


Peptide chain elongation: GTP cleavage catalysed by factors binding aminoacyl-transfer RNA to the ribosome.


Cellular immune response during rejection of a liver transplant in man.


Evaluation of the antisecretory effect of a new anticholinergic agent--heteronium bromide.


The secretion of bile.

The secretion of bile.


Anencephalus and spina bifida.

Anencephalus and spina bifida.


Salmonella typhi murium meningitis in an infant. Case report.


Job Lewis Smith as a founder of the American Pediatric Society.


Obstructive cardiomyopathy.

Obstructive cardiomyopathy.


Preliminary microbiological and pharmacological evaluation of 6-(R-alpha-amino-3-thienylacetamido) penicillanic acid (BL-P 875).


Aromatic amino acid biosynthesis in Trichophyton rubrum. II. Failure to detect endogenous shikimic acid and related substances.


Polynucleotide chain lengths of rapidly labelled and ribosomal RNA of mammalian cells and E. coli.


Optical activity of biopolymers.

Optical activity of biopolymers.


IgM activity in human lymphotoxic antisera after renal transplantation.


Leucocytic pyrogen generated by endotoxin.


The value of karyopyknotic indices from urinary cytology in the determination of ovulation.


Current literature survey of photosynthesis. XV.


A non-photoreactivable mutant of Serratia marcescens.


A method of repairing broken cytology slides.


Electroanesthesia: A review of the literature (1819-1965).


Neuroleptic drugs and conditioned reflexes.


Itroduction of David J. Sencer as Charles Franklin Craig Lecturer for 1968.


Histopathologic changes and small-bowel absorption in falciparum malaria.


A field survey of molluscicide-degrading microorganisms in the Caribbean area.


Survey for antibodies to arboviruses in the serum of various animals in Israel during 1965-1966.


Femoral aneurysmectomy. Management of the profunda femoris artery.


The role of viruses in cancer.

The role of viruses in cancer.


Effect of ATP and its components on induced synthesis of beta-galactosidase in non-growing cells of Escherichia coli.


On the role of S-adenosyl-L-methionine in the biosynthesis of spermidine by rat prostate.


Escherichia coli co (II) alkaline phsophatase.


The lack of messenger activity of ribonucleic acid complementary to the viral ribonucleic acid of bacteriophage R17.


Doctor who saved "Scottsboro boy" retiring as censor.


Two and three dimenstional ultrastructure of boutons and glial cells on the motoneuronal surface in the cat spinal cord.


Renal transplantation at the University of Alabama Medical Center.


Self-conceptions methodologies.

Self-conceptions methodologies.


Systems theory of therapeutic and rehabilitative learning with television.


Oxygen changes in tissues of germfree and conventional mice after inoculation of bacterial endotoxin.


A study of the indigogenic principle and in vitro macrophage differentiation.


The effect of adenosine phosphates on the spreading of normal human platelets.


Arthrography of the knee joint in children. Roentgenologic anatomy, diagnosis and the use of multiple discriminant analysis.


Euripides' Hippolytus.

Euripides' Hippolytus.


Thomas Jefferson: female identification.


Timely topics in clinical chemistry: enzymes and isoenzymes.


The Atkinson Library of Applied Anatomy.


Special June issue to honor Editor Emeritus Pollock.


New Army dental clinic dedicated to General Fairbank.


Pathogenesis of intestinal infections.

Pathogenesis of intestinal infections.


Histoid leprosy.

Histoid leprosy.


Primary reticulum cell sarcoma (microglioma) of brain. An electron microscopic study.


Variations in dietary habits with changing dentitions. A preliminary study.


Lamellar corneal transplantation in rabbits using isobutyl cyanoacrylate.


Tubular function demonstrated in rat kidneys after storage at -79 degrees C.


The role of manometry in the investigation of pelvi-ureteral function.


On organic compounds with a sweet and-or a bitter taste.


Preparation of tissues for liquid scintillation radioactivity counting.


Aortic arch syndrome.

Aortic arch syndrome.


Protein-bound acid-labile phosphate. Isolation of 1-32P-phosphohistidine and 3-32P-phosphohistidine from some mammalian and microbial cell extracts incubated with adenosine triphosphate-32P.


The action of proteolytic enzymes on N,N-dimethyl proteins. Basis for a microassay for proteolytic enzymes.


Effect of growth conditions on amino acids bound to deoxyribonucleic acid.


Purification and properties of beta-isopropylmalate dehydrogenase.


Low dosage buccal oxytocin--a double blind trial in patients with a long induction labour interval.


The priniciples and application of radioimmunoassay with special reference to the gonadotropins.


The treatment of cancrum oris and its complications with dorsal pedicle flaps.


The median forehead flap in reparative surgery of the face.


Lithium as an indicator of proximal sodium reabsorption.


New methods in the field of microtransplants.


The gastrin story.

The gastrin story.


Biochemical modifications in rat skin homografts.


The covered implantation of composite grafts. Indications, techniques, and operative results.


Effects of the genetic relationship between donors and recipients and incompatibility for different antigens in human transplantation.


The history of rhinoplasty.

The history of rhinoplasty.


The indications for and technique of secondary osteoplasty of cleft jaw.


Homologous and heterologous skin transplantation in extensive burns.


More on Cerletti and electric fish.

More on Cerletti and electric fish.


Pseudocoarctation of the aorta associated with congenital heart disease: report of ten cases.


Isozymes of the lactose operon of Escherichia coli.


Recognition mechanisms in the chicken spleen.


Unique pigment in skin window macrophages, associated with recurrent painful ankle ulcers: atropine noir.


Prevention of superficial pyogenic skin infections.


Some aspects of cutaneous malignancy.

Some aspects of cutaneous malignancy.


Chromatographic analysis of molecular species of lipids. A general survey.


Introduction to a discussion of clinical applications of existentialist ideas.


Mefexamide as an antiparkinson drug. (A double-blind study).


Clinical efficacy of unilateral ECT.

Clinical efficacy of unilateral ECT.


The effect of azetidine-2-carboxylic acid on the synthesis of proline in Escherichia coli.


Nocturnal teeth-grinding: a reassessment for dentistry.


Research in physiology of interest to dentistry.


Fluorides in dental practice. A review.

Fluorides in dental practice. A review.


The fine structure of rat incisor enamel.


Effect of tybamate on psychosomatic symptoms in a group of infertility patients. A double-blind study.


Treatment of extensive ameloblastoma by mandibular resection and immediate bone graft: report of a case.


Percutaneous needle biopsy of the testis.


External biphasic pins for fixation and immobilization of a mandibular bone graft: report of case.


Failure of cold-curing acrylic resins.

Failure of cold-curing acrylic resins.


The effect of pseudopregnancy by ovulatory suppressants on the glucose tolerance in women.


Classroom status and perceived performance in sixth graders.


Negro performance on the Hooper Visual Organization Test: impairment or artifact?


Prolonged survival of skin allografts exposed to heterologous antilymphocyte serum in vitro.


A vagally innervated pouch of the oxyntic gland area of the stomach.


The extracellular regulation of liver regeneration.


Amatus Lusitanus (1511-1568). A prophetic physician of the 15th century.


The institution for investigating the nature and cure of cancer. A study of four excerpts.


The influence of the free dispensaries upon medical education in Britain.


The identity of the artists involved in Vesalius's Fabrica 1543.


Pharmaceutical history and its sources in the Wellcome Collections. II. Drug weighing in Britain, c. 1700-1900.


Edward Jenner and the introduction of vaccination in Malta.


Thomas H. Huxley and religion and immortality; a letter from T. Lauder Brunton to Fielding H. Garrison.


James Hardy and the Devonshire Colic.

James Hardy and the Devonshire Colic.


Medicine at Cambridge 1660-1760.

Medicine at Cambridge 1660-1760.


The dissemination of Lister's teaching in Spain.


Pourfour du Petit's experiments on the origin of the sympathetic nerve.


Benedetta Reguardati of Nursia (1398-1469).


On the term diabetes in the works of Aretaeus and Galen.


The ill health of Jane Welsh Carlyle.

The ill health of Jane Welsh Carlyle.


A heart transplantation. 2. The donor.

A heart transplantation. 2. The donor.


A heart transplantation. 3. Surgical and postoperative surgical aspects.


A heart transplantation. 4. Anaesthesia and cardio-pulmonary bypass.


A heart transplantation. 5. Postoperative medical aspects.


Heart transplant.

Heart transplant.


Autoimmune disease.

Autoimmune disease.


The history of Royal Children's Hospital, Brisbane.


"Intal" in the treatment of asthma.

"Intal" in the treatment of asthma.


Family planning in Melbourne.

Family planning in Melbourne.


Evidence for oncogenic properties of heteroploid cell lines--discussion.


Satellite viruses, helper viruses, and synergistic action--discussion.


Neoplastic properties of animal cell lines--summary.


Lincomycin studies of drug absorption and efficacy. An evaluation by double-blind technique in treatment of odontogenic infections.


Stinging insects: allergy implications.

Stinging insects: allergy implications.


A schematic approach to acid-base therapy in the newborn.


Ben H. Nicholson.

Ben H. Nicholson.


History of chemical carcinogenesis: some prospective remarks.


Studies on mechanism of carcinogenesis in the mammary gland.


Chemical carcinogenesis in infant animals.


Carcinogenic cyclopenta[a]phenanthrenes.


Chemical sterilization.

Chemical sterilization.


Developments in agitation and aeration of fermentation systems.


Production of purine nucleotides by fermentation.


Culture of the higher fungi.

Culture of the higher fungi.


Clinical neurology.

Clinical neurology.


Clinical psychiatry.

Clinical psychiatry.


Family therapy.

Family therapy.


Radiation-induced alterations in the structure of deoxyribonucleic acid and their biological consequences.


Drug therapy.

Drug therapy.


The role of conformation in chemical mutagenesis.


The chemical modification of nucleic acids.


A new technique for prosthetic mitral valve fixation: method of continuous mattress SUTURE.


Surgical indications for vagotomy.

Surgical indications for vagotomy.


The carbon-fluorine bond in compounds of biological interest.


Wound healing in the colon: comparison of inverted and everted closures.


Right ventricular performance in dogs following pulmonary valvectomy.


The unstable haemoglobin haemolytic anaemias.


Human tumor-specific antigens.

Human tumor-specific antigens.


Biography of Theodor Kocher.

Biography of Theodor Kocher.


Retarded immunological recovery in sublethally x-irradiated mice by additional thymic exposure. Reversal with injected marrow cells. NRDL-TR-68-119.


The influence estrogens, progestins, and pregnancy on the liver.


The anemia of scurvy.

The anemia of scurvy.


Some aspects of vitamin A metabolism.

Some aspects of vitamin A metabolism.


Tocopherol-responsive anemias in man.

Tocopherol-responsive anemias in man.


Deoxy sugars.

Deoxy sugars.


Emil Fischer and his contribution to carbohydrate chemistry.


Complexe of alkali metals and alkaline-earth metals with carbohydrates.


The effects of plant-growth substances on carbohydrate systems.


The glycofuranosides.

The glycofuranosides.


William O. Maddock, M.D.

William O. Maddock, M.D.


Dr. Stewart R. Roberts' "An Ideal of Modern Medicine".


Chemical synthesis of polysaccharides.

Chemical synthesis of polysaccharides.


Evaluation of some culture media and sampling techniques for the diagnosis of vibriosis in the bull.


Isolation and properties of thiogalactoside transacetylase-negative mutants of Escherichia coli.


Carbohydrate movement from autotrophs to heterotrophs in parasitic and mutualistic symbiosis.


The biology of the lobe-finned fishes.

The biology of the lobe-finned fishes.


Symposium on surgical, immunologic, and ethical considerations of cardiac transplantation in man. Introduction.


Surgical aspects of cardiac transplantation in man.


Immunologic considerations of cardiac transplantation in man.


The ethics of cardiac transplantation in man.


A medical journal and college on New York's northern frontier.


A-cell deficiency and B-cell hyperplasia of Langerhans' islet as a cause of leucine sensitive hypoglycemia.


A study on the mechanism of action of sulfonylurea using 35S-Rastinon.


Latent function analysis in gerontological research.


Intra-uterine growth retardation.

Intra-uterine growth retardation.


Remarks at the presentation of the portrait of Dr. Herman Beerman to the University of Pennsylvania, 15 May 1968.


Tribute to Doctor Herman Beerman.

Tribute to Doctor Herman Beerman.


Herman Beerman, M.D. An appreciation.

Herman Beerman, M.D. An appreciation.


Herman Beerman, M.D. A tribute.

Herman Beerman, M.D. A tribute.


A biography of Herman Beerman, M.D.

A biography of Herman Beerman, M.D.


Clifton O. Dummett.

Clifton O. Dummett.


The effect of a prescribed method of toothbrushing on the fluctuation of marginal gingivitis.


The efficacy of antibiotics in periodontal surgery: a controlled study with lincomycin and placebo in 68 patients.


Dr. Clay Welborn Evatt.

Dr. Clay Welborn Evatt.


Field trials of repository antimalarial compounds.


Ultrastructural localization and distribution of free cholesterol (3-beta-hydroxysterols) in tissues.


Sieve plate pores of Nicotiana.

Sieve plate pores of Nicotiana.


The fixation of pulmonary surfactant for electron microscopy. 1. The alveolar surface lining layer.


The making of a university.

The making of a university.


Death of a Prince Consort.

Death of a Prince Consort.


Colin Ferguson Macdonald.

Colin Ferguson Macdonald.


Genetic analysis of lon mutants of strain K-12 of Escherichia coli.


Thermal responses of mutant enzymes and temperature limits to growth.


Transduction of nitrate reductase loci of Escherichia coli by phages P-1 and lambda.


Official roster of affiliated societies.


Renovascular hypertension.

Renovascular hypertension.


The burns unit in Copenhagen. 3. Treatment and mortality.