Radiosensitivity testing; a modern adjuvant in the treatment of cervical cancer.


Recent advances in culdoscopy.

Recent advances in culdoscopy.


The use of telemetry in prosthetics.

The use of telemetry in prosthetics.


Sectional dentures--aids to removal and adjustment.


Chronic acute hepatitis. A review.

Chronic acute hepatitis. A review.


Progress in malaria chemotherapy. 1. Repository antimalarial drugs.


The cell periphery.

The cell periphery.


Electronic applanation tonometry in corneal edema and keratoplasty.


The "sesamoidal ligament" and its employ in the suturing of the Keller bunionectomy procedure.


Early stages of conjugation in Escherichia coli. We initiated these studies to learn more about the initial events during bacterial conjugation and to optimize conditions for their occurrence. We found that cells in donor cultures grown anaerobically prior to mating have (i) a higher mean number of F pili per cell, (ii) longer F pili, (iii) a higher probability of forming specific pairs with F(-) cells, and (iv) a faster rate of initiation of chromosome transfer than cells grown aerobically. The growth medium for the donor culture also influences these same parameters: a rich medium is superior to a completely synthetic medium. Starvation of donor cells in buffered saline or for a required amino acid results in (i) a loss of F pili, (ii) a loss in the ability of donor-specific phages to adsorb, (iii) a loss of ability to form specific pairs with F(-) cells and to yield recombinants, and (iv) an increase in recipient ability. These changes occur as a function of starvation time, and at rates which are dependent on the conditions of prior growth and starvation of the donor culture. Either treatment provides a rapid method for the production of F(-) phenocopies from donor cultures. Resynthesis of F pili by cells within a starved donor culture commences very soon after restoration of normal growth conditions, but full restoration of donor ability, as measured by recombinant yield, occurs at a slower rate. We found, along with other investigators, that F pili are essential for specific pair formation. We also found, however, that the presence of F pili is not sufficient for display of donor ability, nor is the absence of F pili enough for cells to exhibit recipient ability. This suggests, therefore, that one or more components, in addition to F pili, are necessary for the conversion of specific pairs to effective pairs (or for chromosome mobilization, or both) and for preventing donor cells from acting as recipients. On the basis of our results, we suggest optimal conditions for achieving high mating efficiencies.


Chromosomal location of a gene for fructose 6-phosphate kinase in Escherichia coli.


3-Phosphoserine transaminase mutants of Escherichia coli B. Mutants lacking 3-phosphoserine:oxoglutarate transaminase require pyridoxine and serine for growth.


Enhancement of the lethal effects of endotoxins by interferon inducers. Prior treatment of mice with poly I:C or NDV enhanced the lethal effect of E. coli or B. dermatitidis endotoxins.


Dominance of ultraviolet radiation resistance in partial diploids of Escherichia coli K-12. Although an F'13 capR(+)/capR9 strain is nonmucoid and an F'13 capR9/capR(+) strain is mucoid, both strains are ultraviolet (UV)-resistant. In contrast, haploid capR9 strains are UV-sensitive. Therefore, UV resistance is dominant to UV sensitivity, regardless of whether the capR(+) allele is on the chromosome or on the F'13 episome.


Second pyridine nucleotide-independent 1-alpha-glycerophosphate dehydrogenase in Escherichia coli K-12. A soluble l-alpha-glycerophosphate dehydrogenase, which is stimulated by FAD and is independent of added pyridine nucleotides, functions during anaerobic catabolism of glycerol and l-alpha-glycerophosphate by Escherichia coli.


Method for assessing the frequency of transfer of an R factor on solid media and for isolating cells of the donor type from a predominantly repressed culture. A method for assessing the incidence of R factor transfer on solid media is described. The method gives values similar to those obtained with conventional techniques but allows the derepressed cells from a predominantly repressed population to be isolated.


Stabilization of colicin E2 by bovine serum albumin. Colicin E2 was partially purified from Escherichia coli W3110. This preparation was remarkably stabilized by bovine serum albumin in a solution at neutral pH, as shown by dilution experiments and tests on heat stability of colicin. One killing unit of colicin E2 was estimated to correspond to one molecule of colicin E2, on the assumption of a molecular weight of 60,000.


Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors. R-factor strains which are streptomycin-resistant and spectinomycin-sensitive have been found to inactivate streptomycin by a new mechanism. The 3'-OH group of the 2-deoxy-2-methylamino-l-glucopyranosyl moiety is phosphorylated.


Adult human milk intolerance and intestinal lactase deficiency. A review.


B. F. Skinner's verbal behavior: a retrospective appreciation.


Discriminative responding on associated mixed and multiple schedules as a function of food and ICS reinforcement. Performance on associated mixed and multiple variable-interval-extinction schedules was studied as a function of food versus intracranial stimulation (ICS) reinforcement. For the mixed schedule, differential responding was greater for an ICS reinforcement group than for a food reinforcement group, demonstrating that conditions affecting resistance to extinction help to determine the control exerted by a mixed schedule. Performance on the multiple schedule demonstrated greater differential responding for an ICS group than for a food reinforcement group during the early training sessions, indicating that the control exerted by mixed schedules interacts with that exerted by the exteroceptive discriminative stimuli. The results suggest that the influence of the associated mixed schedule on discriminative responding would be greater, the greater the difficulty of the stimulus discrimination.


A medical flashback.

A medical flashback.


Stable coexistence of three resistance factors (fi-) in Salmonella panama and Escherichia coli K12.


Correlation of bacterial sensitivities to ionizing radiation and mild heating.


Host-controlled restriction mutants of Salmonella typhimurium.


Transduction of pro+ to Salmonella typhimurium proAB47 by phage P22.


Muscular dystrophies.

Muscular dystrophies.


Absence of gastrointestinal bleeding following administration of salicylsalicylic acid.


Quantitative aspects of the measurement of native secretion granule insulin.


Multiple abutment impressions using vacuum adapted temporary splints.


Influence of tray design upon elastic impression materials.


Prosthetic stent for gold-grain implant to the floor of the mouth.


Bacterial cell wall analysis. I. Cell wall preparation.


Triiodothyronine and placebo in the treatment of obesity. A study of fifty-five patients.


Calcium excretion in patients with renal allografts.


The combined effect of alcohol and amitriptyline on skills similar to motor-car driving.


Microdetermination of vitamin A and carotenoids in blood and tissue.


Preparative zonal centrifugation.

Preparative zonal centrifugation.


Neoplasms of blood cell origin in poikilothermic animals; a review.


Tobacco and cancer: the first clinical report, 1761.


Joseph Goldberger, M.D. (1874-1929). Benefactor of mankind. I. Prologue years (1874-1914).


Pierre Charles Alexandre Louis. Influence on American medicine.


Nurses of the year.

Nurses of the year.


An interesting grande multipara.

An interesting grande multipara.


Drug induced retinopathy.

Drug induced retinopathy.


Microsurgical techniques in traumatic conditions of the anterior segment.


An evaluation of the osteogenic potential of frozen marrow.


The thalassemias.

The thalassemias.


Touch and the psychoanalytic tradition.

Touch and the psychoanalytic tradition.


Comments on psychoanalytic biography with special reference to Freud's interest in Woodrow Wilson.


John Ruskin: radical and psychotic genius.


First representations of the gamma alcoholic in the English novel.


Adenohypophysial transmembrane potentials: polarity reversal by elevated external potassium ion concentration. Incubation of rat adenohypophyses in potassium ion of sufficient concentration to provoke the release of several of the adenohypophysial trophic hormones produces a reversed, positive transmembrane potential in more than half the cells. This finding is consistent with a process of "stimulus-secretion coupling" in which hypothalamic releasing factors act by selective depolarization of their "target" cells. The positive potentials may be due to a prolonged preferential permeability to calcium ions triggered by an initial depolarization of the cell membrane to a threshold value by increased external potassium ion.


Effects of atropine on histamine-induced human gastric secretion.


Lacerations of the flexor tendons of the hand.


Facial scar revision.

Facial scar revision.


Finger tip trauma.

Finger tip trauma.


Skin grafting in the emergency room and outpatient department.


Management of facial lacerations.

Management of facial lacerations.


Tarsorrhaphy.

Tarsorrhaphy.


Distillates from Hieronymus Brunschwig's Book of Distillation.


Experimental evaluation of the osteogenic potential of bone graft materials.


The posterior plane of gastro-intestinal sutures.


Psychiatric complications of heart transplants.


Denture retention aids for edentulous wind instrument musicians.


US Army Medical Command--Europe news release.


Coe-Flex and the partial denture impression.


Intraoral skin grafts: an aid to alveolar ridge extensions.


Alternative partial dental design.

Alternative partial dental design.


"6-second impression technic".

"6-second impression technic".


IDA directory 1969-1970.

IDA directory 1969-1970.


Basic principles of model surveying.

Basic principles of model surveying.


Blood volume and extracellular fluid volume in anesthesia.


Directory of medical libraries for dentists in the State of Maryland.


Periodontal pitfalls in the construction of a three unit bridge. II.


Roster of members 1970. Nebraska Dental Association.


Denture identification in nursing homes.


Chariots and charioteers. Chariot racing as an occupation.


Man and his diet.

Man and his diet.


Auxiliary liver homotransplantation. A new technique and an evaluation of current techniques.


Response of renal allografts to erythropoietic stimuli in the presence of immunosuppression.


Major colonic problems in human homotransplant recipients.


Studies on in vitro RNA synthesis in rat brain nuclei: biphasic stimulation of RNA polymerase with ammonium sulfate.


Critical study of 5 per cent guanethidine in ocular manifestations of Graves's disease. Assessment was made of 5% local guanethidine in treating eye manifestations in euthyroid patients with either treated thyrotoxicosis or ophthalmic Graves's disease. In a double-blind crossover study guanethidine caused greater improvement in lid retraction than a control solution. A long-term study showed that this improvement was maintained. A much lower incidence of side-effects was noted with 5% guanethidine than with 10% solution.


Serratia septicaemia.

Serratia septicaemia.


Human babesiosis in Ireland: further observations and the medical significance of this infection. Three splenectomized persons in Yugoslavia, California, and Ireland have been reported to be infected by three different Babesia species; two cases were fatal. In a study of the site where the fatal infection was contracted in Ireland, blood samples from 36 persons who had recently been bitten by ticks were inoculated into two splenectomized calves; no response to Babesia divergens was detected. Field-collected Ixodes ricinus ticks inoculated into another splenectomized calf resulted in fever and recovery of the agent of tick-borne fever (Cytoecetes phagocytophilia). This attempt to determine the presence of latent infection in human beings with intact spleens should be repeated on a larger scale in areas with a demonstrably high incidence of Babesia in ticks and animals. Few places in the world are free of piroplasms; their presence may present a hazard to splenectomized persons or to those whose splenic function is deficient.


Treatment of thyroid cancer.

Treatment of thyroid cancer.


Further details of third recorded case of redwater (Babesiosis) in man. Clinical details and laboratory and postmortem findings of a human case of redwater (piroplasmosis or babesiosis) caused by Babesia divergens. This is the third proved case in man. All three patients had had splenectomies.


A comparison of results of RPCF and TPHA with those of STS.


Circulating antibodies to corneal tissue in a patient suffering from Mooren's ulcer (ulcus rodens corneae).


Anti-adrenal cellular hypersensitivity in Addison's disease. II. Correlation with clinical and serological findings.


Forming method for apatite prostheses.

Forming method for apatite prostheses.


Studies of the binding of ethidium bromide to transfer ribonucleic acid: absorption, fluorescence, ultracentrifugation and kinetic investigations.


Synthesis and maturation of ribosomal RNA in Escherichia coli.


Dependence of f2 bacteriophage RNA replication on amino acids.


DNA replication during episome transfer as studied by bromodeoxyuridine photosensitization.


Replication of the single-stranded DNA bacteriophage M13: messenger RNA synthesis directed by M13 replicative form DNA.


The clinical diagnosis and treatment of microgliomatosis: report of a case.


Thermography in vascular disorders affecting the brain.


Bernardini Ramazzini (1633-1714) physician of the tradesmen.


Lymphocytic thyroiditis possibly induced by diphenylhydantoin.


Aspiration pneumonia following intravenous administration of alcohol during labor.


Puffing of polytene chromosomes in a plant (Phaseolus vulgaris).


Marrow infusions in dogs given midlethal or lethal irradiation.


The genetics of schizophrenic and schizoid disease.


Toxoplasma and toxoplasmosis.

Toxoplasma and toxoplasmosis.


Robert Hebard Bayley, 1906-1969.

Robert Hebard Bayley, 1906-1969.


Experimental endocarditis (Wyssokowitsch, 1886).


Antenatal malnutrition: its relationship to subsequent infant and child development.


Experimental ileotubal anastomosis in the sow.


Relationship of premature rupture of the membranes to gastric fluid aspirate in the newborn.


Collagen nature of asteroid bodies of giant cells in sarcoidosis.


Loss of isoantigens A, B, and H in carcinoma of the lung.


The production of penicillin in the United States. Extracts and editorial comment.


Evaluations of A. N. Richards as a man and as a scientist.


Pseudosepticemia.

Pseudosepticemia.


Immunofluorescent techniques in clinical diagnosis of cutaneous disease.


Recent developments in antithrombotic therapy.


Metabolic consequences of obesity.

Metabolic consequences of obesity.


Psychiatry: circa 1919-1969-2019.

Psychiatry: circa 1919-1969-2019.


Carbenicillin: clinical and laboratory experience with a parenterally administered penicillin for treatment of Pseudomonas infections.


Progressive Coxsackie viral pancarditis and nephritis.


Vitamin D and cardiovascular, renal, and brain damage in infancy and childhood.


Myocardial electrolyte derangement: crucial feature of pluricausal, so-called coronary, heart disease (dysionic cardiopathy).


I.P. Pavlov.

I.P. Pavlov.


Detection of laryngeal disease by computer technique.


Bobby Ray Alford, MD--George E. Shambaugh, Jr., MD, chief editors--Archives of Otolaryngology.


Otoplasty.

Otoplasty.


Construction of the tracheostoma.

Construction of the tracheostoma.


1969 Gold Key Award (Sidney Licht).

1969 Gold Key Award (Sidney Licht).


1969 Gold Key Award (Elizabeth Licht).

1969 Gold Key Award (Elizabeth Licht).


Tumorigenicity of acridine orange.

Tumorigenicity of acridine orange.


Demonstration by the mixed antiglobulin reaction, of antibodies to BP8 tumour cells in immunized mice.


Effect of high- and low-bulk diets on the thyroxine turnover rate in rats with acute and chronic exposure to different temperatures.


Neurologic complications of operations on the descending thoracic aorta.


Human heart transplantation: report of a case.


Psychiatry and poverty: a selected review of the literature.


Recent advances in investigation and treatment of infertility.


Developmental responses to quantity changes in artificial social objects.


A psychiatric interpretation of children's creative dramatic stories.


Pharyngeal flap surgery: a review of the literature.


Epstein-Barr virus-associated antibody patterns in carcinoma of the post-nasal space.


The effect of Bordetella pertussis vaccine on the development of experimental thyroiditis in rats immunized by the intra-lymph node route or into a hind footpad.


Persistence of thyroid microsomal and thyroglobulin antigens in primary cultures of human thyroid epithelium.


Regulation of the cerebral circulation.

Regulation of the cerebral circulation.


Pyruvate formate-lyase reaction in Escherichia coli. The enzymatic system converting an inactive form of the lyase into the catalytically active enzyme.


Biochemistry of the K antigens of Escherichia coli. Formation of the nucleoside diphosphate sugar precursors of the K27 antigen of E. coli 08:K27(A):H-.


Chromatography of 32P-labelled oligonucleotides on thin layers of DEAE-cellulose.


Demonstration of cell-bound antibody by fluorescent microscopy in the intestine of rabbits following live enteral cholera vaccination.


The cellular basis of immunity.

The cellular basis of immunity.


On the synthesis and utilization of glutamine.


Microbial persistence.

Microbial persistence.


Structure and function of hemoglobin.

Structure and function of hemoglobin.


The genome of bacteriophage T4.

The genome of bacteriophage T4.


Mechanisms of pathogenesis in Mycoplasma infection.


Effect of alterations in pulmonary blood flow on lung-exchangeable water in the dog.


Calculation of polypeptide conformation.


Recombination in H1, the gene determining the flagellar antigen-i of Salmonella typhimurium; mapping of H1 and fla mutations.


Assessment of fetal distress--in utero a review.


Geoffrey Hadfield, 17 August 1889--9 January 1968.


The microbiological uses of 2, 3, 5-triphenyltetrazolium chloride.


Ernst Neumark, 20 September 1911-12 July 1967.


Amphotericin B therapy in children; a review of the literature and a case report.


First-drawn picture: a cross-cultural investigation of the DAP.


A family with twins discordant for schizophrenia: a case study.


Absence of adenine-rich ribonucleic acid from purified infectious reovirus 3. The basic properties of released and cell-associated reovirus are the same. Both contained as their total nucleic acid complement only double-stranded ribonucleic acid (RNA) with an adenine content of 28%. Preparations of purified cell-associated virus, but not released virus, contained adenine-rich RNA which could be separated from the virus with little or no loss of infectivity. These adenine-rich ribonucleic acids were present in the virus preparations either as free RNA or associated with some structures of molecular weight less than 25 x 10(6) daltons. In contrast to our previous report, double-stranded reovirus RNA possessed little or no template activity for the Escherichia coli deoxyribonucleic acid and RNA polymerases.


William Osler, 1849-1919. Commemorative issue.


Control of gene function in bacteriophage T4. I. Ribonucleic acid and deoxyribonucleic acid metabolism in T4rII-infected lambda-lysogenic hosts. Deoxyribonucleic acid (DNA) synthesis in T4rII-infected, lambda-lysogenic strains of Escherichia coli proceeds with one-half the rate of T4 wild-infected bacteria and stops 16 min after infection at 37 C. The rates of ribonucleic acid (RNA) synthesis, however, are the same with T4rII and T4 wild. The turnover of pulse-labeled RNA is slow in K strains (half-lives 10 to 20 min) as compared with B strains (half-lives 2.5 to 6 min). Lambda-lysogeny increases the apparent messenger (m) RNA half-lives in pulse-chase experiments. The shutoff of host RNA synthesis in T4rII infected K(lambda) is incomplete. Moreover, the preferential transcription of T4 DNA ceases 13 min after infection, and transcription of host and prophage lambda DNA is resumed. The T4 RNA synthesized in rII-infected K(lambda) contains no late T4 mRNA. The early portion of the T4 genome, however, is transcribed completely. The T4-induced early modification of bacterial RNA polymerase does occur. Resumption of host DNA transcription at 13 min after infection is not associated with a reversal of the above polymerase modification. It is concluded that in lambdalysogenic bacteria T4rII infections are abortive because RNA polymerase is prevented from transcribing late T4 genes.


Memories of Sir William Osler.

Memories of Sir William Osler.


Halsted of Johns Hopkins.

Halsted of Johns Hopkins.


Sir William Osler.

Sir William Osler.


The influence of Osler on his students.

The influence of Osler on his students.


Youthful recollections.

Youthful recollections.


Billy O.

Billy O.


Reminiscences of Osler.

Reminiscences of Osler.


Osler and children.

Osler and children.


William Osler and Bartholomaeus Anglicus' De proprietatibus rerum.


Sir William Osler and Robert Burton's Anatomy of Melancholy.


Osler's writing style.

Osler's writing style.


A portrait of Osler by his contemporaries.


Some recollections of Sir William Osler at Oxford.


Osler. Regius Professor of Medicine, Oxford.


John Collins Warren (1778-1856), early surgeon of Boston.


Bradford's law and the bibliography of science.


The evolution of r factor. A study of a "preantibiotic" community in Borneo.


Pancreatic enlargement by trypsin inhibitor and low molecular weight compounds.


The infant brain following severe malnutrition.


Alleviation of dietary cirrhosis by betaine and other lipotropic agents.


Los Angeles Veterans Administration diet study.


Use of an antimicrobial mouthwash to minimize the bacterial aerosol contamination generated by the high-speed drill.


Ben Earle Fillis. 1889-1969.

Ben Earle Fillis. 1889-1969.


Mechanical circulatory assistance in the treatment of cardiac failure.


Some factors influencing the effect of environmental stressors upon performance.


Time sequences for differentiation in cellular slime molds.


Insecticide residues in California citrus fruits and products.


Codon recognition by enzymatically mischarged valine transfer ribonucleic acid. Direct evidence for the adaptor hypothesis has been obtained by examining the codon recognition of a purified Escherichia coli valine transfer ribonucleic acid which was enzymatically mischarged with phenylalanine labeled with carbn-14 by reaction with purified phenylalanyl-transfer ribonucleic acid synthetase from Neurospora crassa. The mischarged transfer ribonucleic acid recognized the valine codons but failed to recognize the phenylalanine codon when tested in trinucleotide-directed ribosomal binding assay.


Chemoreceptors in bacteria.

Chemoreceptors in bacteria.


5S RNA synthesized by Escherichia coli in presence of chloramphenicol: different 5'-terminal sequences. Escherichia coli cells, grown in the presence of chloramphenicol, synthesize a low molecular weight RNA (CM-5S RNA) not bound to ribosomes which is similar to ribosomal 5S RNA. Oligonucleotide patterns derived from ribonuclease digests of 5S RNA and of CM-5S RNA are indistinguishable except that the 5'-terminal oligonucleotides differ. Whereas the nucleotide sequence of the 5'-terminus of normal 5S RNA is (p)U(p)G-, there are three alternate sequences of the 5'-terminus of CM-5S RNA: (p)U(p)U(p)G-, (p)U(p)U(p)U(p)G-, and (p)A(p)U(p)U(p)U(p)G-.


Structural studies on the M-antigen produced by Salmonella typhimurium 395MRO-M.


Auto-antibodies to pituitary tissue and pituitary hormones in a case of systemic lupus erythematosus.


Antinuclear factors, the antihumanglobulin consumption test, and Wassermann reaction in psoriatic arthritis.


Complement in rheumatoid inflammation.

Complement in rheumatoid inflammation.


Arthritis associated with Yersinia enterocolitica infection.


Structural analysis of colanic acid from Escherichia coli by using methylation and base-catalysed fragmentation. Comparison with polysaccharides from other bacterial sources. Essentially the same methanolysis products were obtained after methylation of the slime and capsular polysaccharides from Escherichia coli K12 (S53 and S53C sub-strains) and the slime polysaccharides from E. coli K12 (S61), Aerobacter cloacae N.C.T.C. 5290 and Salmonella typhimurium SL1543. These were the methyl glycosides of 2-O-methyl-l-fucose, 2,3-di-O-methyl-l-fucose, 2,3-di-O-methyl-d-glucuronic acid methyl ester, 2,4,6-tri-O-methyl-d-glucose, 2,4,6-tri-O-methyl-d-galactose and the pyruvic acid ketal, 4,6-O-(1'-methoxycarbonylethylidene)-2,3-O-methyl-d-galactose. All were identified as crystalline derivatives from an E. coli polysaccharide. The structure of the ketal was proved by proton-magnetic-resonance and mass spectrometry, and by cleavage to pyruvic acid and 2,3-di-O-methyl-d-galactose. All these polysaccharides are therefore regarded as variants on the same fundamental structure for which the name colanic acid is adopted. Although containing the same sugar residues, quite different methanolysis products were obtained after methylation of the extracellular polysaccharide from Klebsiella aerogenes (1.2 strain). The hydroxypropyl ester of E. coli polysaccharide, when treated with base under anhydrous conditions, underwent beta-elimination at the uronate residues with release of a 4,6-O-(1'-alkoxycarbonylethylidene)-d-galactose. Together with the identification of 3-O-(d-glucopyranosyluronic acid)-d-galactose as a partial hydrolysis product, this establishes the nature of most, if not all, of the side chains as O-[4,6-O-(1'-carboxyethylidene)-d-galactopyranosyl]-(1-->4)-O-(d-glucopyranosyluronic acid)-(1-->3)-d-galactopyranosyl...


Fine structure of B-cell from pancreas pieces incubated in vitro.


Glucose kinetics in human obesity.

Glucose kinetics in human obesity.


Immunoreactive insulin, suppressible, and non suppressible insulinlike activities in rats after administration of glucose and induction of hyperglycaemia by mannoheptulose.


Influence of sodium beta-hydroxybutyrate on glucose and free fatty acid metabolism in normal dogs.


Professor J.P. Hoet 1899-1968.

Professor J.P. Hoet 1899-1968.


Decrease in the insulin of rabbit pancreas in late pregnancy.


Cytology of beta-cells in rabbit pancreas pieces incubated in vitro; Effects of glucose and tolbutamide.


Structural lability of zinc-containing secretion granules of pancreatic beta-cells after exposure to hydrogen sulphide.


Glucose metabolism of isolated mammalian islets of Langerhans; effects of glucagon, 2-deoxy-D-glucose and D-mannoheptulose.


Beta-adrenergic stimulation and insulin release in dogs following HB 419.


Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine (Tegretol): double blind crossover trial.


Studies on the mechanism of xylitol-induced insulin secretion in dogs. Effect of its infusion into the pancreatic artery, and the inhibition by epinephrine and diazoxide of xylitol-induced hyperinsulinaemia.


Action of some hypoglycaemic sulphonylureas on the oxygen consumption of isolated pancreatic islets of mice.


Glucose stimulation of insulin secretion from the isolated pancreas of foetal and newborn rats.


Chronic effects of insulin and glucagon upon islet function.


Stability of cytoplasmic microtubules at low temperatures.


Sir Ludwig Guttmann.

Sir Ludwig Guttmann.


Traumatic paraplegia pre-Guttmann.

Traumatic paraplegia pre-Guttmann.


Hypoferremia produced by plasma from endotoxin-treated rats.


A survey of l variation in the Salmonellae.


Editorial. Two decades: one past, one future.


Paradoxical arterial embolism: collective review.


The surgical treatment of varicose ulcers.


Pneumonia following tracheostomy.

Pneumonia following tracheostomy.


Primary adult lactose intolerance and the milking habit: a problem in biological and cultural interrelations. I. Review of the medical research.


Anesthesia for renal transplantation: First experiences.


Paradoxical embolism: its pathophysiology and clinical recognition.


The problems of thrombosis in the deep veins of the leg.


The effects of internal mammary artery implantation on cardiac function and survival following acute coronary artery occlusion.


Encephalocraniocutaneous lipomatosis. A new example of ectomesodermal dysgenesis.


High doses of trifluperazine and tardive dyskinesia.


Subnormal serum folate due to anticonvulsive therapy. A double-blind study of the effect of folic acid treatment in patients with drug-induced subnormal serum folates.


Influence of age and inoculum level on shed pattern of Salmonella typhimurium in chickens.


Factors influencing the intestinal infection of chickens with Salmonella typhimurium.


Differentiation of avian infectious bronchitis virus serotypes by immunofluorescence.


A herpesvirus isolated from kidney cell culture of normal turkeys.


Isolation of Salmonella and Arizona using enrichment media incubated at 35 and 43 c.


A simple and rapid method for dropping chorioallantoic membranes of chick embryos.


The metabolism of valine and isoleucine in Escherichia coli. XVII. The role of induction in the derepression of acetohydroxy acid isomeroreductase.


Properties of a DNA ligase mutant of Escherichia coli. II. Intermediates in DNA replication.


Alteration of RNA polymerase during transcription of phage lambda DNA "in vivo".


Psychoanalysis and social crises.

Psychoanalysis and social crises.


The presence of N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]threonine in serine, methionine and lysine transfer RNA's from Escherichia coli.


In Memoriam. Charles Hegler Gundry, 1906-1969.


Theories of hysteria.

Theories of hysteria.


Toward a medical understanding of marihuana.


Further bacteriological evaluation of virginiamycin.


Input-output models of biological systems: formulation and applicability.


Passage of orally administered tetracycline into the gingival crevice around natural teeth and around protruding subperiosteal implant abutments in man.


Relief of pathologic conditions resulting from resorption.


Implant denture histology: gross and microscopic studies of a human mandible with a 12-year subperiosteal implant denture.


Subperiosteal prosthesis after skin graft into the oral cavity.


Some comments on the endosseous implant, including operative and postoperative care and observations.


Prefabricated parallel pin castings.

Prefabricated parallel pin castings.


A simple technique for castings with pin retention.


Pin castings by a paralleling device and hydrocolloid technique.


Effects of various agents on tumor-bearing implants in bone.


The subperiosteal unilateral implant as a distal abutment and as a support to periodontally involved teeth.


Ten years of experience with cast pin restorations.


Diagnostic puncture of intervertebral disks in sciatica.


Clinical study of guanoxan in the treatment of hypertension.


Dead space during artificial ventilation: gas compression and mechanical dead space.


Cobaltous ion effect on diauxie.

Cobaltous ion effect on diauxie. Cobaltous ions extended the duration of the diauxic lag in Escherichia coli K-12. Growth in glucose in the presence of Co(++) was necessary for the effect. Medium in which cells had been grown in the presence of Co(++) produced an extended lag when inoculated with fresh cells and lactose. Valine was found in this medium. Reversal of the extended lag was brought about by addition of l-isoleucine and related l-amino acids, but not by several metal ions. Cobaltous ion does not inhibit beta-galactosidase or the galactoside permease. These results, together with the known growth sensitivity of K-12 to valine, indicate that Co(++) disturbs the normal valine-isoleucine balance.


Exopolysaccharide colanic acid and its occurrence in the Enterobacteriaceae. A study of strains from the genera Salmonella, Escherichia, and Aerobacter has shown that under appropriate conditions many strains produce an exopolysaccharide slime of identical composition, which has been identified as colanic acid on the basis of its chemical composition and its sensitivity to certain bacteriophage-induced depolymerase enzymes. Chemical analysis shows that the polysaccharide contains O-acetyl groups in addition to the sugars glucose, galactose, fucose, and glucuronic acid. Mild acid hydrolysis has led to the isolation of a beta-glucosylfucose in addition to glucuronic acid containing oligosaccharides. Many strains were found to synthesize colanic acid under normal conditions of growth or under conditions favoring polysaccharide synthesis, whereas others only synthesized colanic acid when the control mechanism was derepressed by p-fluorophenylalanine.


Effect of pH on in vitro phagocytosis of Streptococcus pyogenes. Phagocytosis experiments were performed with mouse peritoneal leucocytes (MPL). The natural pH of the mouse peritoneal cavity was found to be between 6.1 and 6.3. The phagocytic and intracellular killing activities of MPL by pH variations was studied. It was observed that the optimal ingestion and intracellular killing of bacteria is at the natural pH of the peritoneal cavity.


6-phosphogluconolactonase mutants of Escherichia coli and a maltose blue gene. Mutants lacking an enzyme of the oxidative branch of the hexose monophosphate shunt, 6-phosphogluconolactonase (pgl), have been selected as a new class of glucose-negative derivatives of a phosphoglucose isomerase (pgi) mutant. Glucose negativity is not as complete as in mutants lacking phosphoglucose isomerase and glucose-6-phosphate dehydrogenase. Pgi(+), pgl(-) strains have been constructed by transduction and grow almost normally on glucose. Genetic mapping shows that pgl lies between chlD and att-lambda, in the same position as and identical with a blu gene described by Adhya and Schwartz. These blu mutants grown on maltose were recognized by their property to turn blue after treatment with iodine. It is not known how phosphogluconolactonase deficiency causes this reaction; it might be related to accumulation of 6-phosphogluconolactone.


Transketolase mutants of Escherichia coli. Transketolase mutants have been selected after ethyl methane sulfonate mutagenesis of Escherichia coli. These strains are unable to grow on any pentose and, in addition, require a supplement of aromatic amino acids or shikimic acid for normal growth on any other carbon source. Revertants are normal in both respects and also contain transketolase. Transketolase mutants do not require exogenous pentose for growth. Preliminary genetic mapping of the locus is presented.


Nonsense mutations in the maltose A region of the genetic map of Escherichia coli. The isolation of one amber mutation in malQ, one ochre mutation in malP, and seven amber mutations in malT is reported. A study of their phenotypic expressions in the presence of the amber suppressor su(III) and the ochre suppressor su(c) suggests that (i) malQ is the structural gene for amylomaltase; (ii) malQ and the structural gene for maltodextrin phosphorylase, malP, belong to the same operon; (iii) the malT product, which promotes the expression of the malP-malQ operon, is a protein synthesized in limiting amounts by the wild-type strain.


Temperature-sensitive initiation of chromosome replication in a mutant of Escherichia coli. The properties of Escherichia coli mutant D2-47LT indicate that it is temperature-sensitive for a protein required for the initiation of chromosome replication. The results of several different experiments are consistent with this hypothesis, and no support was found for the alternate hypotheses tested. Although the strain is usually unable to initiate replication at 42 C, some of the initiation proteins are apparently synthesized at the restrictive temperature. This can cause initiation on partially replicated, but not completed, chromosomes. It appears that the temperature-sensitive protein is required for initiation on completed chromosomes.


Sulfur-deficient transfer ribonucleic acid in a cysteine-requiring, "relaxed" mutant of Escherichia coli. A cysteine-requiring mutant of the parent strain Escherichia coli Hfr Cavalli (RC(rel), Met(-), lambda) has been isolated. The mutant was selected by using replica plating after mutagenesis by N-methyl-N'-nitro-N-nitrosoguanidine. The mutation appears to be in the gene for sulfite reductase, since the mutant could utilize sulfide but not sulfite as a sulfur source. The mutant was found to be RC(rel) with respect to both methionine and cysteine. During cysteine starvation, transfer ribonucleic acid (tRNA) deficient in 4-thiouracil was produced, and in vivo studies indicate that this tRNA can accept sulfur groups to a greater extent than normal tRNA. Further, there were differences both in the rate and extent of amino acid acceptance between normal and sulfur-deficient tRNA. This suggests that thionucleotides are involved in at least one of the biological functions of the tRNA molecule.


Alterations in the phospholipid composition of Escherichia coli B during growth at different temperatures. The major phospholipid classes of Escherichia coli B, phosphatidyl ethanolamine, cardiolipin, and phosphatidyl glycerol, were quantitated at different stages of the growth cycle. The organisms were incubated at both 27 and 37 C. Significant differences were observed both in the amounts of total lipid phosphorus per gram (dry weight) of cells and in the relative percentages of the individual phospholipids. At 37 C the total amount of lipid phosphorus decreased significantly throughout the growth cycle. However, at 27 C total lipid phosphorus accumulated. The patterns of the three major phospholipid classes of Escherichia coli exhibited complex quantitative changes. In addition, some evidence based on glycerol to phosphate molar ratios indicated that phosphatidyl glycerolphosphate replaced phosphatidyl glycerol during the late growth stages of E. coli B when grown at 27 C. A comparative analysis of phospholipid and fatty acid patterns led to a hypothesis attempting to explain some reported variations in the lipid composition of E. coli under different conditions of growth.


The separation of isoaccepting transfer RNA's and the possible role of tRNA in regulation.


Formation and properties of an aminoacyl-tRNA-GTP-protein complex.


Structure and reactivity of tRNA.

Structure and reactivity of tRNA.


Studies of DNA-dependent RNA polymerase.


Studies on binding of RNA polymerase to DNA.


Subunits of E. coli RNA polymerase in function and structure.


The assembly of ribosomes.

The assembly of ribosomes.


Transcriptional controls in developing bacteriophages.


The induction of tRNA synthesis following T4 phage infection.


Properties of DNA associated with raffinose-isolated pellicles of Paramecium aurelia.


Phage-induced modification of valyl-tRNA synthetase.


Determinants of pulmonary blood volume.

Determinants of pulmonary blood volume. Pulmonary blood volume was determined by the radiocardiographic technique in 49 patients coming to cardiac catheterization. Since this method has not been directly compared with the more commonly used double injection of dye. 25 comparisons were carried out in 13 patients of the series. Agreement was good over a range of 4.5-21.1 heart cycles since there was no statistically significant difference between transit time values measured by the two methods. The relation of pulmonary blood volume to other hemodynamic factors in these 49 patients, with and without cardiac or pulmonary disease, was evaluated by means of multiple regression analysis. The analysis carried out for mean transit time indicates that this parameter varies predominately with flow. Pulmonary blood volume, in this series of resting recumbent individuals, varies to a significant degree only with total blood volume and with pulmonary venous pressure. No parameters of vascular distensibility, such as pulmonary vascular resistance, were found to affect the volume of blood in the lungs. The fact that variations in pulmonary blood volume among the subjects could be described by a multiple regression equation linear with respect to total blood volume and pulmonary venous pressure indicates that these variations are the result of passive distention of components of the vascular bed.


Water, acidosis, and experimental pyelonephritis. The effect of water restriction and ammonium chloride acidosis on the course of Escherichia coli pyelonephritis was determined in the nonobstructed kidney of the rat. To alter the chemical composition of the renal medulla, water intake was reduced in rats to one-half the normal daily intake. Water restriction increased the incidence of coliform pyelonephritis. Systemic acidosis, produced by giving a 300 mM solution of ammonium chloride, increased urinary osmolality to values comparable to water restriction and also predisposed to pyelonephritis. However, when rats were fed the same solution of ammonium chloride but were allowed access to tap water ad lib., urinary osmolality values were comparable to those observed in normal animals, and susceptibility to pyelonephritis was reduced or eliminated despite a degree of systemic acidosis similar to that observed in rats fed ammonium chloride solution without access to tap water. These results suggest that water diuresis may overcome the inactivation of complement produced by ammonium chloride acidosis and that renal medullary hypertonicity, produced by either water restriction or ammonium chloride acidosis, is a major determinant of this tissue's unique susceptibility to infection.


New hearts for old?

New hearts for old?


In memoriam James Edward Ackert.

In memoriam James Edward Ackert.


The causes of progressive pulmonary insufficiency in surgical patients.


Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects.


Endogenous carbon monoxide production.

Endogenous carbon monoxide production.


Rubella antibody screening in a prenatal clinic using the indirect fluorescent method.


Mucous membrane pemphigoid-immunofluorescent studies.


Mandibulo-facial restoration with live osteocutaneous flaps.


Studies on the effectiveness of surgical management of chronic leg ulcers.


Hyperbaric oxygen and pedicle flaps, skin grafts, and burns.


Strombeck mammaplasty with free nipple grafts.


The surgical treatment of transsexual patients. Limitations and indications.


Demineralization studies of fluoride-treated enamel using scanning electron microscopy.


In vivo observations of the effects of imuran on the microvasculature within fullthickness mouse skin allografts.


The surgical treatment of submucous cleft palate.


The deformity termed "pug nose" and its correction, by a simple operation: John O. Roe, M.D., Rochester, N.Y. (Reprinted from The Medical Record, June 4, 1887).


Chemotherapeutic activity of the combination of trimethoprim and sulphamethoxazole in infections of mice.


Practical aspects of testing sensitivity to trimethoprim and sulphonamide.


Bacteriological, pharmacological and clinical studies with trimethoprim-sulphonamide combinations with particular reference to the treatment of urinary infections.


Combined trimethoprim-sulfisoxazole therapy of urinary infections. Clinical studies.


Treatment of exacerbations of chronic chest infections with combinations of sulphamethoxazole4trimethoprim (including comparison with ampicillin).


Comparison of tetracycline and trimethoprim-sulphamethoxazole in acute episodes in chronic chest infections.


Possible Pythagorean influences on Plato's views of physical education in The Republic.


Corneal auto-transplant: a report of 3 cases.


Treatment of poultry with ionizing radiations to destroy salmonellae. TID-24887.


Human heart transplantation for cardiomyopathy.


The effect of gamma rays on haddock and clams inoculated with Clostridium botulinum, type E. TID-24885.


The significance of Clostridium botulinum type E in the application of radiation-pasteurization process to Pacific crab meat and flounder. TID-24880.


The significance of Clostridium botulinum type E in the application of radiation-pasteurization process to Pacific crab meat and flounder. TID-24883.


A brief review of 210Pb metabolism. HASL-204.


Recent publications related to radionuclide studies. HASL-210.


Recent publications related to radionuclide studies. HASL-204.


The Swann Committee.

The Swann Committee.


The pure-tone air conduction audiogram.

The pure-tone air conduction audiogram.


Harvey Franklin Dingman.

Harvey Franklin Dingman.


Experimental immune diabetes in the rabbit. Light, fluorescence, and electron microscopic studies.


Studies of emotional behavior of humans and animals by Soviet physiologists.


Pharmacological studies on the brain mechanisms underlying two forms of behavioral excitation: stereotyped hyperactivity and "rage".


The subclavian steal syndrome.

The subclavian steal syndrome.


Round table discussion: divalent ion metabolism and osteodystrophy in chronic renal failure.


Pharmacology and toxicology of ophthalmic drugs.


Drug reactions. VII. Photosensitivity to systemically administered drugs.


The other side of the brain. 3. The corpus callosum and creativity.


Association of luteinizing hormone-releasing factor with granules separated from equine hypophysial stalk.


Stimulation of insulin secretion by guanidinoacetic acid and other guanidine derivatives.


Environmental aspects of methylenedioxyphenyl and related derivatives.


New concepts of digitalis.

New concepts of digitalis. The data presented in this review have substantiated the following ideas:* There is a direct relationship between digitalis dosage and myocardial contractile force. A small dose of digitalis produces a small increase of the contractile force of the heart and a large dose increases the force of the heart's contraction by a much greater amount, whether the heart is normal, has a poor reserve, or is in frank failure.* Digitalis is of benefit to the patient with cardiovascular disease whether his heart is in failure or not.


Hans Spemann and the organizer concept.

Hans Spemann and the organizer concept.


European legislation on flavourings.

European legislation on flavourings.


Estimation of the exposure of the general population to dieldrin (HEOD).


Characterization of allotype A11 in rabbits: a specificity detected by agglutination.


Present and future measures for dental caries control.


Application of ribonuclease T1 to the synthesis of oligoribonucleotides of defined base sequence.


The incorporation of beta-hydroxy fatty acids into a phospholipid of Escherichia coli B.


Studies on the mechanism of fatty acid synthesis. XXII. Salt activation of the fatty acid-synthesizing enzymes of Escherichia coli.


The role of deoxyribonucleic acid in ribonucleic acid synthesis. XVII. Multiple active sites of Escherichia coli ribonucleic acid polymerase.


Studies on 5-fluorouracil-containing ribonucleic acid. 3. Greatly reduced level of 5,6-dihydrouridine in fluorouracil-containing transfer ribonucleic acid from Escherichia coli.


Studies on the migratory behavior of melanocytes in guinea pig skin. Pigment spread is the natural or experimentally procured (through grafting) progressive encroachment of pigmentation from black or red skin areas into juxtaposed white skin areas, or from black skin areas into red skin areas in spotted guinea pigs and other mammals. So far as spread from black into white skin is concerned, it had previously been shown that migration of epidermal melanocytes into skin lacking homologues of these cells was responsible. However, since red skin already has its own complement of phenotypically "red" melanocytes, the intriguing possibility remained that when black pigment encroaches upon red, rather than melanocyte migration being responsible, phaeomelanin (red)-producing melanocytes are transformed into eumelanin (black)-producing cells by some kind of serially transmissible factor derived from contiguous eumelanotic melanocytes. By utilizing two isogenic strains (Nos. 2 and 13) of spotted guinea pigs and their F(1) hybrids, the mechanism underlying the spread of pigment from black into red skin has been analyzed, employing cellular transplantation antigens as melanocyte "markers." The findings demonstrate unequivocally that a physical migration of pigment cells is responsible. By comparing the extents of pigment spread from black ear skin grafts, or from epidermal cell suspensions prepared therefrom, from parental strain or from F(1) hybrid donors in white host skin areas of F(1) hybrid guinea pigs, it has been possible to evaluate the influence of the intimate contact of melanocytes with alien transplantation antigens on their survival and migratory behavior. No evidence was forthcoming that pigment spread takes place less readily when the cells responsible are confronted by epidermal cells bearing foreign antigens than when they are confronted by cells of their own antigenic constitution. These findings are contrary to expectation if the phenomena of allogeneic inhibition or contact-induced cytotoxicity apply to normal cells in in vivo situations.


The presence of anti-glomerular basement membrane antibodies in peripheral blood.


Studies on the pathogenesis of fever. 18. Activation of leukocytes for pyrogen production. Blood leukocytes, in contrast to exudate leukocytes, release little or no pyrogen when incubated in 0.15 M NaCl unless previously activated by exposure to endotoxin or to a protein activator that is present in acute exudate fluid. The activation process, which also occurs during phagocytosis, involves the synthesis of cellular protein, presumably related to the pyrogen molecule. Evidence is presented that generation of pyrogen in sterile inflammatory lesions depends on both the activator and the anaerobic conditions in the exudate fluid.


A half century of sterility 1840-1890.

A half century of sterility 1840-1890.


C. Lee Buxton, M.D. A memorial.

C. Lee Buxton, M.D. A memorial.


Mechanisms of endotoxin tolerance. V. Specificity of the early and late phases of pyrogenic tolerance.


Mechanisms of endotoxin tolerance. VI. Transfer of the "anamnestic" tolerant response with primed spleen cells.


Alterations in host responses to experimental Candida albicans infections by bacterial endotoxin.


In memoriam--doctors of Hawaii. Rafe Nelson Hatt.


Different specificities in antisera prepared against Escherichia coli tryptophan synthetase alpha subunit.


Thymus-derived cells in the early phase of delayed tuberculin reactions.


The etiology and treatment of pemphigus and pemphigoid.


The use of human skin for the detection of anti-epithelial autoantibodies. A diagnostic and prognostic test.


Immunopathologic studies of experimental pemphigus-like autoantibodies and bullous-like lesions.


In memoriam.

In memoriam.


Implications of contraception. A. Metabolic effects of oral contraceptives.


Translation and translocation of defined RNA messengers.


Effect of diet on protein synthesis and nucleic acid levels in rat liver.


Studies of the exoerythrocytic stages of simian malaria. IV. Plasmodium brasilianum.


Leonard W. Edwards--a tribute.

Leonard W. Edwards--a tribute.


The fine structure of tropomyosin crystals.


Philippe Ricord (1800-1889), syphilographer.


Felix Hoppe-Seyler (1825-1895) physiological chemist.


The Veterans Administration clinical investigator program. A 12-year follow-up.


Antonio Maria Valsalva (1666-1723), Valsalva maneuver.


Toxoplasmosis in patients receiving immunosuppressive therapy.


Frank Saverio Pellegrini, M.D.

Frank Saverio Pellegrini, M.D.


The Veterans Administration medical program.


Cardiac pacing in the prevention and treatment of tachyarrhythmias.


The clinical use of immunosuppression.

The clinical use of immunosuppression.


Gastric evacuation and clinical syndromes.


Cellular basis and clinical evaluation of antiarrhythmic therapy.


Harry Leigh Cook.

Harry Leigh Cook.


Chemical measurements in the detection of cancer. A review.


The use of drugs in the patient with uremia.


Isolation of pure lac operon DNA.

Isolation of pure lac operon DNA.


Fatty acids as regulators of glucagon secretion.


The coronary arteriogram. I. Structural and functional aspects.


"Autoallergic" hepatitis.

"Autoallergic" hepatitis.


Plasma growth hormone concentration after a single intramuscular injection of human growth hormone.


On reconciling the "multidimensional" and "unitary" concepts of brain damage.


Advances in the treatment of renal disease.


Intracarotid and intravertebral injection of drugs.


Studies on the mechanism of steroid hormone regulation of synthesis of specific proteins.


A model for the regulation of ovulation in the rat.


Biosynthesis and release of vasopressin and neurophysin.


The history of sleeping sickness in Yimbo location (Central Nyanza, Kenya) as told by the oldest inhabitants of the location.


A reconsideration of the problem of elephantiasis.


Comparative studies on development of rabies virus in different host cells.


Clinical trials on a new antitussive agent. 2-morpholinoethylic ester of a-phenoxyisobutyric acid (morphethylbutyne).


Comparative investigations on the activity of thiosulphate-sulphur transferase.


The automated reagin test: results compared with VDRL and FTA-ABS tests.


A comparison of methods for the quantitation of bacteria in burn wounds. II. Clinical evaluation.


Cephaloridine in septic abortion. Comparison with a conventional combined antibiotic regimen in a conservative program of management.


The control of color in mammals.

The control of color in mammals.


The doctor of medicine and the doctor of philosophy.


Improvement of hearing in cases of otosclerosis. "Improvement of hearing in cases of otosclerosis. A new, one stage surgical technic" by Julius Lempert.


Reliability of cytologic smear in diagnosis of oral cancer. A controlled study.


A comparison of Patho-Tec tm test papers and standard methods in the identification of enteric organisms.


The Bayesian outlook and its application.


Risk of contamination from the anesthesia circle absorber: an evaluation.


Trauma Rounds at the Montreal General Hospital: crushed fingers.


The Royal Vic.

The Royal Vic.


A sensitive double-isotope derivative assay for norepinephrine and epinephrine. Normal resting human plasma levels.


Fifth annual Becton, Dickinson and Company Oacar Schwidetzky Memorial Lecture (Krantz JC Jr).


The development of dentistry in the Western Frontier of New York, 1800-1850.


The history of stomatology in the U.S.S.R.


Some characteristic features of the history of stomatology in Bulgaria.


Factors influencing the evolution of the oral apparatus of the early inhabitants of Rumania.


Studies on the autonomy of pellicular DNA in Paramecium.


The pH dependence of the dephosphorylated pepsin-catalyzed hydrolysis of N-acetyl-L-phenylalanyl-L-tyrosine methyl ester.


Medicare coverage for the post-hospital patient.


Industrialization, child-rearing practices, and children's personality.


Current publications in gerontology and geriatrics.


Anesthetic implications for simultaneous cardiorenal transplant: a case report.


Richard Dennis Arnold. Savannah physician and Unionist in the years of crisis 1832-1861.


Intermittent positive pressure ventilation in hyaline membrane disease.


Positive pressure ventilation in the newborn infant: the use of a face mask.


The effects of testosterone treatment in Klinefelter's syndrome.


The use of hair root sheath for X-chromatin determination.


Job's syndrome.

Job's syndrome.


Mist therapy: rationale and practice.

Mist therapy: rationale and practice.


Development of Eimeria auburnensis in cell cultures.


Cytochemical changes in aging Ochromonas; evidence for an alkaline phosphatase.


A review of cholesteatoma pathology.

A review of cholesteatoma pathology.


Nucleotide sequences present within the 16S ribosomal RNA of Escherichia coli.


Effects of cell wall polysaccharide on the mating ability of Salmonella typhimurium.


Electrophysiological correlate of binocular depth perception in man.


Effects of amygdaloid lesions on hypothalamic-hypophyseal growth-hormone activity.


Endocrine aspects of the mammalian pineal gland: a review.


Regional ventilation and perfusion after lung transplantation in patients with emphysema.


Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects (second of three parts).


The other lung.

The other lung.


Fuller Albright (1900-1969).

Fuller Albright (1900-1969).


Effect of tissue preparation on determinations of disaccharidase activities in intestinal mucosa.


Caffey's syndrome: some unusual ocular manifestations.


Calcitonin: its nature and role in man.

Calcitonin: its nature and role in man.


Otitis media: a clinical and bacteriological correlation.


Nutritional disorders of ruminants.

Nutritional disorders of ruminants.


Methodology of cerebral blood flow measurement.


Dimensions of interpersonal facilitation in psychotherapy and child development.


Cytoplasmic microtubules and radial-segmented nuclei (Rieder cells). Effects of vinblastine, sulfhydryl reagents, heparin and caffeine.


The people of York: 1538-1812.

The people of York: 1538-1812.


The recognition of DNA in bacteria.

The recognition of DNA in bacteria.


Orthotopic transplantation of the porcine liver.


Current management of diabetes mellitus.


A survey of techniques and results of hiatus hernia repair.


Blood flow and oxygen consumption in patients with severe burns.


Oliguria following transplantation of kidneys donated by blood relatives.


Hemostasis, blood coagulation, and isobutyl cyanoacrylate tissue adhesive.


Immunofluorescent studies after ligation of the pancreatic duct.


Determination of vascular status of pedicle skin flaps by use of radioactive pertechnetate (99mTc).


Non-inflammatory diarrhoea. Disaccharidase deficiency in man.


Helminthic and certain other diseases.

Helminthic and certain other diseases.


Histocompatibility antigens and transplantation.


International nonproprietary names for pharmaceutical substances.


Hemodynamic and vascular responses to antihypertensive treatment with adrenergic blocking agents: a review.


Clinical pharmacologic evaluation of the antiatherosclerotic agent, pyridinolcarbamate. A double-blind crossover trial in the treatment of atherosclerosis obliterans.


Beta-hemolytic streptococcal infection. The clinical and epidemiologic importance of the number of organisms found in cultures.


Osler and pediatrics.

Osler and pediatrics.


An historical note on chemotherapy of bacterial infections (Gerhard Domagk).


Benign lymphoepithelial lesion of the parotid glands associated with reticulum cell sarcoma. Report of a case and review of the literature.


Chronic malabsorption (steatorrhea, nontropical sprue) in an adolescent, with death from malignant lymphoma, histiocytic type (reticulum cell sarcoma).


Efferent fibers of the habenula and stria medullaris thalami in rats.


Synovial effusion changes in idiopathic septic arthritis in calves.


The structure of colanic acid.

The structure of colanic acid.


Structural changes in Escherichia coli cells infected with phi-chi-174 type bacteriophages.


The relation of K antigens to the complement sensitivity of strains of Escherichia coli.


Virulence of Salmonella strains with a reduced amount of O-antigen.


Taxonomy of the genus Thiobacillus: the outcome of numerical taxonomy applied to the group as a whole.


Structure, function and biosynthesis of the rigid layer of Escherichia coli cell wall.


The action of penicillin on the mucopeptide of Escherichia coli.


Bacterial N-acetyl-beta-glucosaminidases.


Further studies of P2 associated education in Escherichia coli K12.


Phage receptor development after the addition of galactose to a galactose-epimeraseless mutant of Salmonella typhimurium.


The preparation and use of a new type of bacterial immunoabsorbent column.


A bacteriocinogenic factor of Enterobacter cloacae.


Transduction and dominance studies of the envA gene present in a chain-forming mutant of Escherichia coli K 12.


Cell division and DNA synthesis in a chain-forming derivative of Escherichia coli K 12.


AmpB a mutation which affects the cell envelope and ampicillin resistance in Escherichia coli.


Use of sex specific phages for demonstration of cell surface changes mediated by genes for ampicillin resistance in escherichia coli.


A mutated R-factor mediating increased resistance to several antibiotics.


Regulation of RNA formation in T-even phage infected bacteria: shut-off of early mRNA synthesis.


Regulation of early mRNA formation in T-even phage infected bacteria: dependnce on protein synthesis.


Regulation of protein synthesis directed by coliphage MS2 RNA. II. In vitro repression by phage coat protein.


Another species of ribonucleic acid in Escherichia coli.


Electron microscopy of Escherichia coli polynucleotide phosphorylase molecules and polyribonucleotide formation.


Cardiac output in the exercising dog: an evaluation of the dye-dilution method using the electromagnetic flowmeter as a standard.


Glottic reconstruction following extended frontolateral hemilaryngectomy.


Protuberances on the cell surface of E. coli after exposure to gramicidin S.


The Tomes' process of bat ameloblasts.

The Tomes' process of bat ameloblasts.


Reaction of the gingiva to the application of threads in the gingival pocket for taking impressions with elastic material. An experimental histological study.


Improved contrast in subtraction technique.


Forrest Bertram Ames, M.D., 1891-1969.

Forrest Bertram Ames, M.D., 1891-1969.


Angiography in pulseless disease.

Angiography in pulseless disease.


Avulsion of the innominate artery from the aortic arch. An evaluation of roentgenographic findings.


Fiber sizes and frequencies in the optic nerve of Rana esculenta.


Scanning electron microscopy of the vitreous body in the rat eye.


Granular cytoplasmic bodies in oocytes of the golden hamsters during the post-natal period.


Ultrastructure and secretory cycle of the gastrin-producing cell.


Joseph Asbury Bell. 1904-1968. A biographical appreciation.


Hippocrates and ophthalmology.

Hippocrates and ophthalmology.


Clinical experience with a new type of contrast medium in angiocardiography and thoracic aortography.


Changes in total light scattering and absorption caused by changes in particle conformation--a test of theory.


The effect of substrates on the hydrogen-tritium exchange of the isoleucy1-tRNA synthetase from E. coli.


Nucleotide binding by Escherichia coli membranes and solubilized membrane proteins.


Absolute optical cross sections of cells and chloroplasts.


L-O-Ethylthreonine--an antagonist of L-isoleucine.


Lymphocyte transformation tests in patients under treatment with immunosuppressive drugs.


Specimen preparation for quantitative microradiography.


Asthma and the psychiatrist.

Asthma and the psychiatrist.


The effects of nitrous oxide on the human auditory evoked response.


Elizabeth C. Crosby.

Elizabeth C. Crosby.


The many effects of griseofulvin.

The many effects of griseofulvin.


Early medical journals in Alabama.

Early medical journals in Alabama.


Medical practice in New Orleans. Colonial period.


The Birmingham Medical College.

The Birmingham Medical College.


Delayed hypersensitivity reactions in the gastrointestinal tract. IV. Effects of chronicity, neostigmine, adjuvant, and endotoxin on the pig colon lesion.


Absence of immune phenomenon in gonadotropin-resistant hypogonadism.


The first fifty or one hundred years.

The first fifty or one hundred years.


Stimulation by intrauterine devices of leukocytic responses and bactericidal activity in the sheep uterus.


Julius Neumueller--a teacher of optics.

Julius Neumueller--a teacher of optics.


Cerebrovascular diseases associated with the use of oral contraceptives. A review of the English-language literature.


The immunosuppressive effect of thoracic duct drainage in human kidney transplantation.


Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflammatory agent. I. Serum concentration studies in healthy individuals and in patients with rheumatoid arthritis.


Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflamatory agent. II. Clinical trial in patients with rheumatoid arthritis.


Joint irrigation in rheumatoid arthritis: a controlled trial.


The characterization of enamel surface demineralization, remineralization, and associated hardness changes in human and bovine material.


Dilution studies in experimental hemorrhagic and endotoxic shock: a critical look at the excessive deficits of extracellular space in shocked dogs.


The occurrence of atypical crystals in human cellular cementum fixed in phosphate-buffered fixatives.


Cariogenic streptococci in infants.

Cariogenic streptococci in infants.


Identification of collagen in synovial fluid.


Joint infection by anaerobic bacteria: a case report and review of the literature.


Significance of persistent differences between normal and rheumatoid synovial membrane cells in culture.


Christianus Helwich on difficulty of respiration (Augsburg, 1722).


On clinical medicine with notes from the diary of a part-time researcher.


Unpublished papers of Thomas Hodgkin.

Unpublished papers of Thomas Hodgkin.


Paulus Zacchias on mental deficiency and on deafness.


Professor S. M. Weidmann, 1904-1969.

Professor S. M. Weidmann, 1904-1969.


Hippocrates' home revisited.

Hippocrates' home revisited.


Gram-negative endotoxin shock due to Serratia marcescens.


Studies on biological active component in garlic (Allium scorodoprasm L. or Allium sativum). I. Thioglycoside.


The role of myoinositol in metabolic control. II. The effects of medium constituents and other factors on acetoin accumulation in Saccharomyces carlsbergensis 4228 (ATCC 9080).


Prominent chemotherapeutic properties of the N-oxide derivatives of (5-nitro-2-furyl)vinyl heterocycles.


Effects of clomiphene citrate on pituitary FSH, FSH-RF, and release of LH in immature and mature rats.


Dr. Bobbs' first operation for drainage of a diseased gallbladder.


Models for the secretion of pepsin in man.


Surface structure of intestinal epithelium.


Cephalometrics as an aid to prosthetic treatment of facial disharmonies: report of case.


Carbohydrate digestion and absorption.

Carbohydrate digestion and absorption.


Treatment of a pseudo-class 3 malocclusion and associated follicular cyst: report of case.


Systems analysis methods for integrative diagnosis.


The effect of figure-ground reversal in H-T-P drawings by spastic cerebral palsied children.


A syringe-activated event marker.

A syringe-activated event marker.


Intra- and intermolecular crosslinks in collagen in tendon, cartilage and bone.


SSA regulations for coverage of injections.


Cancer of the naso-pharynx in Nigeria.

Cancer of the naso-pharynx in Nigeria.


Orientation of transcription of the lac operon and its repressor gene in Escherichia coli.


Degradation of polyuridylic acid by ribonuclease II: protection by ribosomes.


Stability of different ribosomal complexes with initiator transfer RNA and synthetic messenger RNA.


A specific DNA methylase induced by bacteriophage 15.


Mutations caused by the insertion of genetic material into the galactose operon of Escherichia coli.


Drugs for the cancer surgeon.

Drugs for the cancer surgeon.


Ocular tumours in animals.

Ocular tumours in animals.


Experimental heart transplant in the dog: discussion.


Short term preservation of porcine livers.


A useful arterial anastomosis technique in orthotopic liver homotransplantation.


Active immunization against E. coli as a protective measure against haemorrhagic shock.


Spatial magnitude electrocardiogram in normals and myocardial infarctions: clinical usefulness of spatial magnitude ECG in the diagnosis of old myocardial infarctions.


A single tray, dual material technique for immediate dentures.


Origin and growth of dental group practice and closed panels.


Spina bifida.

Spina bifida.


Chest roentgenographic findings in the acute rejection crisis in human cardiac transplants.


Simultaneous aterial and venous angiography in the evaluation of anterior mediastinal tumors.


Theodore Roosevelt's role in the 1905 football controversy.


A study on the effect of lanatoside C on ventricular automaticity in man.


Crystal shape in the prism sheath region of sound human enamel.


Reticulum cell sarcoma treated by radiotherapy. Significance of clinical features upon the prognosis.


Detection of minor antituberculosis drugs in the urine.


Heterogenous populations of C. burneti and selection analysis of them.


Electrophysiology of vascular smooth muscle.


The effect of veratridine on excitable membranes of nerve and muscle.


Cyto- and myeloarchitecture of the visual cortex of the cat and of the surrounding integration cortices.


Clinical evaluation of the new analgesic piritramide.


The role of electrolytes in affective disorders. Sodium, potassium, and lithium ions.


Drug-personality interaction in intensive outpatient treatment.


Phosphotransacetylase of Escherichia coli B, purification and properties.


Controlled chemoprophylaxis trials in tuberculosis. A general review.


Purification and characterization of fully deuterated enzymes.


Activity against a synthetic substrate by a preparation of extracellular proteinase from Serratia marcescens.


Creutzfeldt-Jakob disease. The neuropathology of a transmission experiment.


Immunochemical studies on Salmonella typhi. VI. The sugar ratios in Cetavlon fractions from typhoid bacilii S and R forms.


Amino-terminal groups in zymogen activation: effect of nitrous acid on pepsin.


Metabolism of phosphoglycerides in E. coli. IV. The positional specificity and properties of phospholipase A.


In vitro protein synthesis directed by R17 viral ribonucleic acid. II. On the fate of mRNA in the cell-free system.


Pulmonary rectilinear scan with visualization of the great vessels: a possible source of error in interpretation.


Electronmicroscopic observations on Auerbach's plexus in a 12 mm human embryo.


Partial vesical immobilization: an important adjunct to ureteroneocystostomy.


Chronic bacterial prostatitis and the diffusion of drugs into prostatic fluid.


Prostatic fossa packing via cystostomy tube: an aid to hemostasis in selected cases.


The management of urinary incontinence following prostatectomy by the procedure of tubular cutaneous flap: a preliminary note of operative technique.


Urinary infection: review of 16,154 consecutive patients.


Serum and urine levels following parenteral administration of sodium colistimethate to normal individuals.


American Urological Association, Inc.

American Urological Association, Inc.


Ethiopathogenesis of bronchogenic pulmonar carcinoma in miners from uranium mines.


Procedures for control of mycoplasma contamination of tissue cultures.


The role of grief and fear in the death of kidney transplant patients.


Tympanoplasty.

Tympanoplasty.


Fluorescence study of interactions between valyl- t RNA synthetase and valine-specific tRNA's from Escherichia coli.


Current bibliography.

Current bibliography.


Electrode placement and the effect of E.C.T. on mood and memory in depression.


Mechanical problems of the airway.

Mechanical problems of the airway.


Microbiology of the pulp and periapical tissues: culture control.


The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro.


Biological activity of the terpenoids and their derivatives--recent advances.


Intraoral skin grafts: an aid to alveolar ridge extensions.


Pituitary cybernetics and neoplasia.

Pituitary cybernetics and neoplasia.


External pin fixation for treatment of mandibular fractures: a reappraisal.


Grafts of cancellous bone and marrow for restoration of avulsion defects of the mandible: report of two cases.


Biographical essay.

Biographical essay.


Prodigiosene [5-(2-pyrryl)-2,2-'-dipyrrylmethene] and some substituted prodigiosenes.


Sir Theodore Turquet de Mayerne, M.D., F.R.C.P. (1573-1655). Stuart Physician and observer.


A queer sort of thing.

A queer sort of thing.


Abraham Zacutus Lusitanus (1957-1642).

Abraham Zacutus Lusitanus (1957-1642).


Tributes to Sir Ludwig Guttmann.

Tributes to Sir Ludwig Guttmann.


Genetic aspects of liver disease associated with jaundice.


The genetics of muscular dystrophy.

The genetics of muscular dystrophy.


Overview of nursing research 1955-1968. I.


Directory of alumni OF Loma Linda University School of Dentistry.


Human mycoplasma infections.

Human mycoplasma infections.


On the discovery of DNA by Friedrich Miescher 100 years ago.


Infectious endocarditis following cardiac surgery.


An historical note: James Stuart Plant, 1890-1947.


Community psychiatry and ethics.

Community psychiatry and ethics.


The ultrastructure of early rejection phenomena in lung homografts in dogs.


The effect of endotoxin on the implantation of a mouse sarcoma.


Decrease of melting temperature and single strand scission of DNA by bleomycin in the presence of 2-mercaptoethanol.


Peritoneal infections in patients on long-term peritoneal dialysis before and after human cadaveric renal transplantation. Long-term peritoneal dialysis was carried out on 38 patients awaiting human cadaveric renal transplantation. Fifty-eight per cent of patients developed infection before transplantation and 41% of those requiring dialysis after transplantation became infected. Infection did not usually occur before the third day of dialysis and 26% of patients developed their first episode of infection in the first week. Almost 50% of patients had only a single episode of infection. The overall rate of infection per 100 patient days of dialysis was 1.23 before transplantation and 4.17 after transplantation. The commonest infecting organisms were Staph aureus and Staph albus and these organisms were frequently isolated from the skin around the dialysis catheter before the infection occurred. Gram-negative infections were more commonly seen after transplantation.Sixty-five per cent of the infections responded to a single course of antibiotic therapy administered in the dialysis fluid. After transplantation Gram-negative infections were usually associated with severe complications and were a major cause of death. Peritoneal dialysis is a convenient way of maintaining patients with chronic renal failure before human cadaveric renal transplantation, and infection, although common is not inevitable, provided precautions are taken to ensure that the dialysis procedure is carried out using aseptic techniques and prophylactic therapy is applied to the skin around the dialysis catheter.


Quantitative enzyme cytochemistry of leukaemic cells. A new technique for the quantitative estimation of glycolytic and respiratory enzyme activity in intact and unfixed bone marrow and peripheral blood cells is described. The method gives a two- to three-fold increase in demonstrable enzyme activity per cell compared with existing techniques using fixed marrow film preparations, and is particularly applicable to the study of relatively fragile cells such as the leukaemic lymphoblast.


Intestinal microflora in Asiatic cholera. I. "Rice-water" stool.


Is suppression of fever or hypothermia useful in experimental and clinical infectious diseases?


Intestinal microflora in Asiatic cholera. II. The small bowel.


Therapeutic value of oxygen at normal and hyperbaric pressure in experimental head injury.


Mutagenesis in Escherichia coli. IV. Photosensitization to near ultraviolet light by 8-methoxypsoralen.


Urease defective mutants in Neurospora crassa.


Surgical treatment of aortic stenosis.

Surgical treatment of aortic stenosis.


The role of tonsils in predisposing to streptococcal infections and recurrences of rheumatic fever.


Results of surgical treatment of the atrial septal defect.


Clinical and electromyographic study of Charcot disease and related pictures. Machine-aided differential diagnosis.


Basic considerations for the establishment of a bone-marrow bank. (General part).


L-asparaginase-induced immunosuppression: effects on antibody-forming cells and serum titers. Treatment of mice with L-asparaginase from Escherichia coli resulted in a marked suppression of the immune response, as assessed both cellularly and humorally. Suppression occurred only when the enzyme was injected together with the sheep erythrocytes used as antigen. There was little or no effect when the enzyme was injected before the antigen. Simultaneous injection of asparagine prevented suppression, an indication that the effect of the enzyme was due to depletion of an amino acid probably essential for normal lymphoid cell function during antibody production.


Toxoplasma gondii in cats: fecal stages identified as coccidian oocysts. Isospora-type oocysts were excreted by cats following the ingestion of Toxoplasma fromn infected mice. Oocysts appeared 3 to 5 days after cyst. were ingested and 8 to 10 days after trophozoites were ingested, and also 21 to 24 days after the administration of infective fecal suspensions from cats. A close quanititative and biologic correlation between oocysts and Toxoplasma infectivity of the feces was observed which could not be separated by density gradient centrifugation and filtration methods. Toxoplasma is an intestinal coccidian of cats which is fecally spread. It has evolved to multiply in brain and muscle and in other species, making it possible for carnivorism to become another means of transmission.


The growth-duplication cycle. I. Synchronous bacterial cultures. ANL-7409.


The growth-duplication cycle. II. Linear cell growth in bacteria. ANL-7409.


The growth-duplication cycle. V. Absence of the requirement for a specific energy source for uptake of growth factors. ANL-7409.


The growth-duplication cycle. IV. Constancy of uptake of labeled growth factors. ANL-7409.


The growth-duplication cycle. VI. Control of growth and cell division. ANL-7409.


Mutagenesis in bacteria by visible light. ANL-7409.


Action spectrum for protection of E. coli against ultraviolet effects of atebrin. ANL-7409.


Genetic analysis of a large cell strain of Escherichia coli. ANL-7409.


An automatic time-programmed sample collector. ANL-7409.


Design of a multiunit automatic sampling system. ANL-7409.


Trophoblast development gradient and its relationship to placental hemodynamics.


Delayed implantation of the blastocyst: an exploration of its effects on the developing embryo.


Studies on the neurosecretory system of active and hibernating adults of the house cricket, Gryllodes sigillatus (Walk).


Anatomical alteration of hyper-reactivity in rats with septal lesions.


Degeneration of erythrocytes in fish blood.


Rheumatoid arthritis: comparison of treatment with monophenylbutazone and phenylbutazone. A double-blind trial has been carried out to compare the effects of monobutazone and phenylbutazone in ambulant outpatients with rheumatoid arthritis.One patient developed urticaria, vertigo, weakness, tinnitus and blurred vision during monobutazone administration.Side effects occurring in other patients were for the most part trivial.Untoward symptoms were less frequent in patients taking monobutazone than among those on phenylbutazone.The subjects showed neither improvement nor deterioration during administration of ASA, monophenylbutazone or phenylbutazone.Nevertheless, statistical analysis demonstrated differences between the effects of treatment with monobutazone and phenylbutazone which indicated that phenylbutazone is more effective than monobutazone.


L-dopa therapy in Parkinson's disease: a critical review of nine years' experience. The last 10 years have seen great activity in the investigation of cerebral catecholamines, particular attention having been paid to dopamine. The low dopamine content in the basal ganglia and in the urine of patients with Parkinson's disease led to the logical use of the precursor DOPA in the treatment of this disorder. Between 1961 and 1966, both the oral and the intravenous routes were utilized and some effects were noted upon akinesia and rigidity. The doses then used were low and the results remained somewhat controversial. When higher oral levels of L-dopa were introduced, the beneficial action of L-dopa upon parkinsonian symptoms and signs was proved beyond doubt, but there came to light a number of troublesome side effects, the worst of which were hypotension and a variety of abnormal involuntary movements. Recently, new approaches to the therapy have been tried and the sum total of these observations is to challenge our peace of mind regarding a seemingly logical chain of events. We are convinced that such second thoughts will eventually result in better and safer methods of treating this too frequent and disabling neurological disorder.


Interferon: a review.

Interferon: a review.


Clinical antidepressant activity of cyclazocine--a narcotic antagonist.


Clinical evaluation of perhexiline maleate.


Effects of SU-13437 on serum lipids in hyperlipoproteinemic patients.


Nobel prize winners in medicine.

Nobel prize winners in medicine.


Comparison of muscle actin and ciliary microtubule protein in the mollusk Pecten irradians.


Structure and function of Escherichia coli ribosomes. VI. Mechanism of assembly of 30 s ribosomes studied in vitro.


Scintillation camera in the evaluation of renal transplants.


Foreign literature on antibiotics. 78.

Foreign literature on antibiotics. 78.


The inner history of the Johns Hopkins Hospital.


Plasma volume expansion in portal hypertension.


Serum fucose levels and their response to glucose loading in diabetics.


Effect of glucocorticoids on plasma growth hormone in man.


Sequential study of arginine monochloride and normal saline as stimuli to growth hormone release.


Glucose intolerance mechanism after starvation.


Comparison of the determination of cardiac output by the dye dilution method and electromagnetic flowmetry.


Quasi-simultaneous cardiac output determinations in dogs with the direct Fick method (O2 and CO2) and with the dye dilution method using a linear reflection densitometer.


Determination of the ejection fraction of the left ventricle.


Fibrillating activity of the urinary bladder and the effect of electrical counter-shock in a case of multiple sclerosis.


Arterio-venous shunts in peripheral vascular systems.


The significance of photoelectric plethysmography, thermography and venous occlusion plethysmography in the investigation of the peripheral circulation.


Human leucocyte typing in clinical transplantation.


Some aspects of the medical management of peptic ulceration.


The vascularization of a free full thickness skin graft. II. A microangiographic study.


The vascularization of a free full thickness skin graft. 3. An infrared thermographic study.


The vascularization of a free full thickness skin graft. I. A vital microscopic study.


Bromelain--a proteolytic enzyme.

Bromelain--a proteolytic enzyme.


A head from ancient Corinth.

A head from ancient Corinth.


Studies on burns. X. Changes in BMR and evaporative water loss in the treatment of severe burns with warm dry air.


The surgical treatment of advanced postmastectomy lymphoedema of the upper limb. With the late results of treatment by the buried dermis flap operation.


Results and correlations of multistage exercise tests in a group of clinically normal business executives.


The use of the digital computer in the study of patients during exercise-induced stress.


Hyperthyroidism as a high cardiac output state.


The effect of isoniazid on performance in school.


A human case of Mycobacterium bovis infection in Georgia.


High-output, low-resistance gram-negative septic shock in man.


Postpericardiotomy syndromes.

Postpericardiotomy syndromes.


Anomalous pulmonary venous drainage of the left upper lobe.


Physicochemical properties of N4 virus solutions. I. Viscosity--temperature behavior.


Fibrinolytic activity and the skin.

Fibrinolytic activity and the skin.


Dermatology in Tudor and early Stuart England.


Predicting verbal participation in group therapy.


A comparison of propanidid (Epontol) and thiopentone anaesthesia in ECT.


Chemotherapy of cancer.

Chemotherapy of cancer.


Ocular (pigmentary) effects of psychotropic drugs.


The application of gel filtration to the study of protein-binding of small molecules.


Clofazimine (Lamprene) in leprosy.

Clofazimine (Lamprene) in leprosy.


Serotonin and sleep.

Serotonin and sleep.


Some effects of hormones on sleep.

Some effects of hormones on sleep.


Time courses of excitation and inhibition in retinal ganglion cells.


The treatment of impotence with methyltestosterone thyroid (100 patients--double blind study).


Chromosomal transfer mediated by de-repressed R factors in F- Escherichia coli K12.


Bacterial flora associated with the human gastrointestinal mucosa.


A method for isolating paralysed (mot-) mutants from non-flagellated cells of Salmonella.


Carcinoma of the pancreas. Diagnosis and treatment.


Operator constitutive mutations in the leucine operon of Salmonella typhimurium.


A study of delayed hypersensitivity of guinea pigs to vaccinia virus. Comparison of inhibition of cell migration to a local passive transfer reaction for the quantification of delayed hypersensitivity.


Kinetics of phagocytosis of bacteria opsonized with natural or immune antibodies.


Henry Wilson, M.D., F.R.C.S.I.

Henry Wilson, M.D., F.R.C.S.I.


Oral anticoagulants--their interactions.


Preparation of isolated rat liver mitochondria for electron microscopy. A comparative study of the fixation of isolated rat liver mitochondria was undertaken. If the criterion is adopted that after processing, the mitochondria should resemble as closely as possible rat liver mitochondria in situ, the procedure found to produce such preservation was that of fixation in suspension in veronal-buffered 2% potassium permanganate. Fixation in osmium tetroxide produced variable results, while mitochondria fixed in glutaraldehyde were contracted. We suggest that in cases where fixation procedures modify the morphological appearance of mitochondria, the significance of such changes must be treated with caution.


Experience with phenformin as an oral antidiabetic agent.


Nature of magnesium-induced miscoding.

Nature of magnesium-induced miscoding.


Insect sperm: their structure and morphogenesis.


Polyribosomes of Escherichia coli. I. Effects of monovalent cations on the distribution of polysomes, ribosomes and ribosomal subunits.


Ribosomal protein synthesis during and after amino acid starvation in relaxed and stringent bacteria.


Electron microscopy of transfer RNA.

Electron microscopy of transfer RNA.


Mitochondrial and cytoplasmic ribosomes from Neurospora crassa: characterization of their subunits.


Restoration of in-phase translation by an unlinked suppressor of a frameshift mutation in Salmonella typhimurium.


Diversion and reversal of cerebral blood flow. External carotid artery "steal".


Opsonins.

Opsonins.


A field on Che.

A field on Che.


Nutritional science and society.

Nutritional science and society.


Edwards A. Park.

Edwards A. Park.


Double blind fluid therapy evaluation in pediatric cholera.


Constellations of the zodiac: a cultural Rorschach test?


The corticosteroids in childhood.

The corticosteroids in childhood.


The prevention and treatment of gastroenteritis in infancy.


Great men of the University of Bologna.

Great men of the University of Bologna.


Dr. I. A. Galloway.

Dr. I. A. Galloway.


Transformation of mouse cells by K-papovavirus.


Pool sizes of fd bacteriophage components in infected bacterial cells.


A defective P1 prophage with a chromosomal location.


Characterization of REP- mutants and their interaction with P2 phage.


Computer calculation of two target trajectory with "centre of arc-target" stereotaxic equipment.


Reconstruction of proximal humerus by muscle-sling prosthesis.


FEL--a process for teaching interpersonal relationships.


A study of the glia and the fibres of the cerebral plexiform layer in the cat.


Measurment of hepatic parenchymal cell and nuclear area of tadpoles at different stages of development.


Immunofluorescent studies of pemphigus foliaceus in a child.


Zinc therapy and distribution in psoriasis.


Paul Langerhans: a tribute.

Paul Langerhans: a tribute.


Coding properties of methyl-deficient phenylalanyl transfer ribonucleic acid from Escherichia coli.


Effect of allosteric effectors and adenosine triphosphate on the aggregation and rate of inhibition by N-ethylmaleimide of carbamyl phosphate synthetase of Escherichia coli.


Garvan Award address of the American Chemical Society: peptidase activity and peptide metabolism in Escherichia coli K-12.


Diagnosis of psychopathology using stepwise multiple discriminant analysis. I.


Toward a rational approach to psychedelics: the controversy over popular use from a clinical viewpoint.


Lactose malabsorption after gastric surgery.


Inhibition of gastric secretion by bacterial lipopolysaccharide in the rat.


Probability of F integration and frequency of stable Hfr donors in F+ populations of Escherichia coli K-12.


Kinetics of f transfer and recombinant production in F+ times F- matings in Escherichia coli K-12.


F+ strains of Escherichia coli K-12 defective in Hfr formation.


Enzyme repressibility and repressor effectiveness in phenotypic revertants of arginine auxotrophs.


A simple quantitative and qualitative microbiological screening test for bacteriuria. A simple, accurate screening test for significant bacteriuria is described. It entails brief contact of a freshly voided specimen of urine with the surface of a solid culture medium lining the wall of a transparent disposable plastic container, incubating it at 37 degrees C for 24 hours, and counting colonies developing on a proscribed surface area. The method obviates errors due to contaminants, affords a limited species differentiation of the causative organisms, and provides a ready means of obtaining a direct sensitivity test on the responsible bacteria.


Catecholamine metabolite excretion in spina bifida. The urinary excretion of vanilmandelic acid (VMA), homovanillic acid (HVA), and parahydroxyphenylacetic acid (pHPAA) was measured in 55 children with meningomyelocoele selected at random. In 96% of the children the levels of one or other of these compounds was significantly raised above the normal, usually by a factor of about 3. High VMA levels usually meant high HVA levels but the values for pHPAA appeared to be quite independent of the others. These results suggest a disorder of tyrosine metabolism, and the possible implications are discussed.


Storage of virus-infected tissue culture substrates for the detection of serum antibodies by immunofluorescence.


Use of soluble swabs in the diagnosis of bladder neoplasia. A technique is described for obtaining samples of bladder epithelium using soluble swabs. Changes indicating neoplasia were seen in a large proportion of patients with bladder carcinoma. These changes were absent in the non-neoplastic control cases. The method provided tissue similar to that obtained by biopsy and surgical removal. The cellular appearances resembled those seen in neoplastic cells exfoliated into urine.


Some haematological aspects of renal transplantation.


The bacteriology of traveller's diarrhoea.


Steady state operation of a continuous culture at maximum growth rate by control of carbon dioxide production.


Genetic mapping of the phoR regulator gene of alkaline phosphatase in Escherichia coli.


Surface topography of ultramicrotome sections.


The extracellular space in the developing rat brain: its variation with changes in osmolarity of the fixative, method of fixation and maturation.


Bacterial quantification of peritoneal exudates.


Cardiothoracic surgery.

Cardiothoracic surgery.


Gastrointestinal biliary conditions.

Gastrointestinal biliary conditions.


Otorhinolaryngology.

Otorhinolaryngology.


Orthopedic surgery.

Orthopedic surgery.


Urology.

Urology.


Transplantation.

Transplantation.


The origin and evolutionary principals of spring forceps.


Use of diuretic agents during oliguria after renal transplantation.


Accelerated rejection of skin grafts in recipients sensitized with extracted human histocompatibility antigens.


The effect of liver disease on the need for venous decompression during the anhepatic phase of canine orthotopic liver transplantation.


Autoradiographic studies on the incorporation of foreign DNA and RNA into kidney allografts.


Effects of phytohemagglutinin on humoral antibody response, delayed hypersensitivity, and homograft rejection.


A method of salvaging the bifurcated saphenous vein for use in femoral-to-popliteal bypass grafts.


Further studies of R-factor satellite DNA.


The fine structure of the sense organs of the cephalopod mollusc Nautilus.


Fine structure of the eyes of Onithochiton neglectus (Mollusca: Polyplacophora).


On the fine structure of the gas gland in some fishes.


Recent trends in the synthesis of linear peptides.


Cytologic study of radiation changes in carcinoma of the oral cavity: prognostic value of various observations.


Sex chromatin patterns in buccal smears in breast cancer in Indian women.


Pharmacological testing methods for drugs acting on the peripheral nervous system.


The teaching of psychiatry to medical students: past, present, and future.


Methodological considerations in evaluating antianxiety drugs.


The eye problem in laser safety.

The eye problem in laser safety.


Clinical consideration influencing experimental design in drug trials for migraine headache therapy.


Renal allotransplantation in humans. I. Systemic immunosuppressive therapy.


Permanent skin homografting in identical twins.


Experimental technique for perfusion of the canine donor heart in vitro.


Relief of bladder spasm by flavoxate. A comparative study.


Further studies of antilymphoid sera in clinical renal allotransplantation.


Methoxyflurane analgesia for burns dressings: experience with the analgizer.


Convulsions in the postoperative period. A case report.


Opening of the pleural cavity as a complication of operations in the lumbar region. A case report.


Experimental and clinical studies on rifampicin in treatment of leprosy. Rifampicin showed high activity against experimental leprosy, inhibiting the multiplication of dapsone-sensitive and dapsone-resistant strains of Mycobacterium leprae in mice fed 5 mg./kg. body weight. In a formal pilot-type trial on six previously untreated patients with active lepromatous leprosy, rifampicin (600 mg. daily by mouth) was as effective as standard treatment with dapsone. Myco. leprae, however, appeared to be killed more rapidly by rifampicin than by dapsone or other antileprosy drugs so far studied. This was confirmed on a further 10 patients, including two with dapsone resistance, and from the infectivity in mice of bacilli recovered from patients during treatment with rifampicin or dapsone. These results are consistent with the bactericidal activity of rifampicin against other micro-organisms, which could be important to the chemotherapy of leprosy, since all antileprosy drugs in current use are bacteriostatic.


Bile salts.

Bile salts.


The inhibition of bactericidal activity of sera of newborn germ-free piglets to rough Escherichia coli by yeast mannan.


Periodic changes of beta-galactosidase in Escherichia coli B in the chemostat.


Quantitative analysis of the chimeric state in mice. 3. Comparison of the colonizing capacities of syngeneic cell suspensions from different sources.


The effect of acriflavine on complement sensitive and resistant strains of Escherichia coli and on complement resistant mutants.


Quantitative analysis of the chimeric state in mice. IV. Cytological examination of mice rendered tolerant by neonatal inoculation of F1 hybrid spleen cells.


Antigenic stimulation of bone marrow colony forming cells. I. Effect of antigens on normal bone marrow cells in vitro.


Comparisons of results of different patient evaluation methods in clinical psychopharmacology.


Contact and delayed hypersensitivity in the mouse. 3. Depression of contact sensitivity by pre-treatment with antigen and the restoration of immune competence in tolerant mice by normal lymphoid and bone marrow cells.


Review of therapeutic properties of emetine in nonamoebic infections.


Reduction of serum lipids in familial hyperlipidemias by a tetralin derivative.


Mode of action of adjuvants: retinol and other lysosome-labilizing agents as adjuvants.


Experimental concurrence of pemphigus-like autoantibodies and bullous-like lesions.


The immediate effect of rapid infusion of different fluids on static lung compliance and central venous pressure.


Mode of action of adjuvants: effects on antibody responses to macrophage-associated bovine serum albumin.


A model for the interaction of cell types in the generation of hemolytic plaque-forming cells.


Primary gastrointestinal lymphoma.

Primary gastrointestinal lymphoma.


The comparative immunosuppressive effects of heterologous antisera to various C3H mouse tissues.


Detection of hemopoietic allografts by localization of radiolabeled alloantibodies.


2,4-dinitrophenyl-hapten specific hemolytic plaque-in-gel formation by mouse myeloma (MOPC-315) cells.


Isolation of molecules of restricted allotype from antistreptococcal polysaccharide antibody.


Pathological and ultrastructural findings in a case of heart transplantation.


Genetic investigation of a biblical myth.


The antigenicity of E. coli asparaginase.


Autoradiographic study of the incorporation of tritiated cholesterol into the zona reticularis of the rat adrenal cortex.


Mutation affecting the charging reaction of alanyl-tRNA synthetase from Escherichia coli K 10.


Trachoma among the Navajo Indians.

Trachoma among the Navajo Indians.


Extraocular muscle recessions utilizing silicone tendon prostheses.


Transplantation antigens in keratoplasty. I. Isolation of a soluble fraction with transplantation antigen activity.


A calorimetric study of the binding of two feedback inhibitors to the glutamine synthetase from Escherichia coli.


Ribosomal protein pools and the assembly of ribosomes in Escherichia coli.