Synthetic capabilities of plasmolyzed cells and spheroplasts of Escherichia coli. Effects of plasmolysis and spheroplast formation on deoxyribonucleic acid (DNA), ribonucleic acid (RNA), protein, and phospholipid synthesis by Escherichia coli strain THU were studied. RNA and protein synthesis were severely diminished. DNA and phospholipid synthesis were inhibited, but less so; they could be partly restored. DNA synthesis could be restored by replacing thymine in the medium with thymidine, and phospholipid synthesis, by adding back small quantities of soluble cell extract. Plasmolysis effected marked reductions in rates of growth and macro-molecule synthesis, and temporarily reduced culture viability. Plasmolysis also caused an anomalous stimulation of phospholipid synthesis. Spheroplasts and plasmolyzed cells synthesized small amounts of ribosomal RNA that sedimented normally. However, this ribosomal RNA was very inefficiently packaged to ribosome subunits. Spheroplasts were unable to carry out induced synthesis of beta-galactosidase, and plasmolyzed cells were delayed in this function. Radioautographs examined in an electron microscope showed that DNA synthesis in plasmolyzed cells and spheroplasts was performed by a substantial fraction of the culture populations. That DNA and membrane were associated in the spheroplasts used in this study was suggested by formation of M-bands containing membrane and most of the cell's DNA. The results are discussed in terms of alterations of membrane structure and conformation attending plasmolysis and spheroplasting.


Evidence for a surface protein layer on the Saccharomyces cerevisiae ascospore. Electrophoretic measurements on Saccharomyces cerevisiae ascospores indicated the presence of a surface protein layer which can be removed by papain, chymotrypsin or 8 m urea.


Degradation of enteric bacterial deoxyribonucleic acid by the Escherichia coli B restriction endonuclease. The deoxyribonucleic acid of five different genera of enteric microorganisms was shown to be degraded by the Escherichia coli B restriction endonuclease.


Genetic location in Escherichia coli K-12 of the ultraviolet-sensitive mutation uvrD3. A host cell reactivation-negative mutation, uvrD3, in Escherichia coli K-12 is located between ilv and metE.


Genetic control of the secondary modification of deoxyribonucleic acid in Escherichia coli. The wild-type restriction and modification alleles of Escherichia coli K-12 and B were found to have no measurable effect on the patterns of methylated bases in the deoxyribonucleic acid (DNA) of these strains. The genetic region controlling the methylation of cytosine in E. coli K-12 was mapped close to his, and the presence or absence of this gene in E. coli B or E. coli K had no effect on the restriction and modification properties of these strains. Thus, only a few of the methylated bases in the DNA of these strains are involved in host modification, and the biological role of the remainder remains obscure.


Host-induced modification-restriction and the utilization of 5-bromouracil by thymineless mutants of Escherichia coli. An m(k) (-)r(k) (-) mutation exerted no measurable effect on 5-bromouracil incorporation by a thymineless derivative of Escherichia coli K.


Response of Laotian malaria strains to chemotherapy.


Immunological studies on Yoshida sarcoma cells. II. Cellular localization of heterologous anti-yoshida sarcoma cell antibodies and immunohemolytic anemia induced by their injections in the rat.


Effect of colistin on the formation of hemolysin by group A hemolytic streptococci.


Genetic properties of a T factor and T-r recombinants.


Factors affecting the germination of spores of Clostridium botulinum type E.


Genetic structure of F-lac-tet factor.

Genetic structure of F-lac-tet factor.


Susceptibility of E. coli K-12 to actinomycin D after infection with phage M13.


Localization of acyl carrier protein in Escherichia coli.


Isolation of the arginine repressor in Escherichia coli.


Investigation of leucocytes from chickens with Marek's disease.


Lymphocyte-mediated transport of aggregated human gamma-globulin into germinal centre areas of normal mouse spleen.


Antibody response to tumour xenografts in mice treated with antilymphocyte serum.


Education of a gynecologic oncologist.

Education of a gynecologic oncologist.


Hyperthyroidism during pregnancy.

Hyperthyroidism during pregnancy.


Urethrovesical suspension for female urinary incontinence: refinements of INCO needle.


Medicine's responsibilities.

Medicine's responsibilities.


The clinician-pathologist.

The clinician-pathologist.


Bella trachtenberg: an appreciation.

Bella trachtenberg: an appreciation.


Peyton Rous: in memoriam. 1879-1970.

Peyton Rous: in memoriam. 1879-1970.


Observations concerning the increase of mankind, peopling of countries, etc.


The milk-ejection reflex: a neuroendocrine theme in biology, myth and art.


Iowa medicine: prospect and retrospect.

Iowa medicine: prospect and retrospect.


Friedrich Wassermann, 1884-1969. A life in experimental cytology.


Some genetic aspects of plantation slavery.


The role of affect in the structure of schizophrenic psychosis of childhood.


Assessment of severity of isolated valvar pulmonic stenosis using isoproterenol.


Arthur Covel Curtis 1898-1970.

Arthur Covel Curtis 1898-1970.


Specious syphilography.

Specious syphilography.


Secondary enzyme-substrate interactions and the specificity of pepsin.


Effects of dimethyl sulfoxide on the degradation of ribonucleic acid catalyzed by alkali.


On the basis of specific fragmentation of ribonucleic acid by nucleases.


2'-O-methyloligoadenylates as templates for the binding of lysyl transfer ribonucleic acid to ribosomes.


Inhibition of peptide-chain initiation in Escherichia coli by hydroxylamine and effects on ribonucleic acid synthesis.


Transfer of N-acetylglucosamine from uridine diphosphate N-acetylglucosamine to 3,15 alpha-dihydroxyestra-1,3,5(10)-trien-17-one by human adult and fetal kidney homogenates.


Correlation of transfer RNA methylase activity with growth and differentiation in normal and neoplastic tissues.


Studies on deoxythymidine kinase of regenerating rat liver and Escherichia coli.


Effect of a potent carcinogen, 4-nitroquinoline 1-oxide, and its reduced form, 4-hydroxylaminoquinoline 1-oxide, on bacterial and bacteriophage genomes.


Structure and function in Gall.

Structure and function in Gall.


Robert Montgomery Bird, physician and novelist: a case for long-overdue recognition.


Businessmen and public health in the urban south during the nineteenth century: New Orleans, Memphis, and Atlanta.


The protoplasmic theory of life and the vitalist-mechanist debate.


On the Pao P'u Tzu Nei P'ien and the life of Ko Hung (283-343).


Galen on contaminated cereals as a cause of epidemics.


Henry Cavendish: a study of rational empiricism in eighteenth-century natural philosophy.


Pattern recognition in Descartes' automata.


A psychological comparative study of the Samaritan community: Shchem (Nablus) and Holon. General survey.


Israel Barzilai (1913-1970).

Israel Barzilai (1913-1970).


Anxiety arousing effects of inappropriate crowding.


Hygiene conditions in ancient Israel (iron age).


Cholera in Newark, New Jersey.

Cholera in Newark, New Jersey.


The 1832 epidemic of Asiatic cholera in New Haven, Connecticut.


La pharmacie rustique. Sketched by Gottfried Locher in 1774; engraved by Barthelemi Hübner in 1775.


Mixed-function oxidase involvement in the biochemistry of insecticide synergists.


Digoxin: immunologic approaches to measurement and reversal of toxicity.


Remarks to honor Henry Walter Brosin, M.D.


Two Luthers: the traditional and the heretical in Freudian psychology.


Allport's visit with Freud.

Allport's visit with Freud.


Dostoevsky and "The Gambler": a contribution to the psychogenesis of gambling. 1.


The insulin test.

The insulin test.


Combination of sulphamethoxazole and trimethoprim in the treatment of acute and chronic bronchitis.


Projective test content during pregnancy and postpartum adjustment.


Sensory deprivation on visceral activity. II. The effect of auditory and vestibular deprivation on canine gastric secretion.


Transcription of the lambdadv plasmid and inhibition of lambda phages in lambdadv carrier cells of Escherichia coli.


Phenotypic mixing between bacteriophage phi80 and lambda in vitro and in vivo.


Possible function of rII genes of bacteriophage T4.


Rudolph Manninger 1890-1970.

Rudolph Manninger 1890-1970.


Gaubius on inflammation. II.

Gaubius on inflammation. II.


A tool for keeping up with the literature--"Abridged Index Medicus".


Dentists' hearing: the effect of high speed drill.


Are there alternatives to the porcelain fused to gold bridge?


Modern materials in dental practice.

Modern materials in dental practice.


A study of the properties of some present-day acrylic materials used in restorative dentistry.


A comparison of the effectiveness with which p-aminobenzoic acid and p-aminobenzoylglutamic acid are used as substrate by dihydropteroate synthetase from Escherichia coli.


The electroformed gold matrix inlay technique.


An imprint-spreading procedure for electron microscopy of selected cells in situ.


The formation of biliverdin by chicken macrophages in tissue culture. Observations on the effect of inhibitors.


Differential response to lithium carbonate in manic depressive and schizo-affective disorders.


Metronidazole and alcoholism. (An evaluation of specific and non specific factors in drug treatment).


Electrical monitoring of the acutely ill patient.


Inflammatory diseases of the subcutaneous fat.


Studies on biochemical, nutritional, serological and antibiotic sensitivity characters of the strains of Escherichia coli of diverse origin.


Distribution and causative agents of surgical infections in cattle.


Tuberculosis. Review of work done in India in the last twenty-five years.


Indian pediatrics. Its achievements in twenty-five years and expectations.


Nuclear medicine in India.

Nuclear medicine in India.


Twenty-five years of dermatovenereology in India. A review.


Leprosy work in India.

Leprosy work in India.


A review on occupational medicine based on recent work done in India.


Diuretics.

Diuretics.


Cardiology in India during the last twenty five years.


A quarter century of neurology in India.


The incidence of chronic pyelonephritis diagnosed by renal biopsy and bacterial counts in pre-eclamptic and eclamptic women.


Size and nature of the protein gap.

Size and nature of the protein gap.


Calcium and fat absorption in newborn infants.


Sugar and coronary heart disease.

Sugar and coronary heart disease.


Evidence for liver damage in subjects fed amino acid diets lacking arginine and histidine.


Adrenal control of copper mobilization and transport.


The significance of fluorides in fish protein concentrates.


Metabolic changes in "meal-fed" rats.

Metabolic changes in "meal-fed" rats.


Biotin and glucokinase in the diabetic rat.


Phospholipid biosynthesis in rat liver mitochondria.


Dietary copper and the melting point of pig adipose tissue.


Evaluation of a rapid bedside screening test for asymptomatic urinary tract infection--a preliminary communication.


Precocious puberty.

Precocious puberty.


Clinical implications of recent advances in the understanding of calcium metabolism.


The natural history of isolated ventricular septal defect with special reference to selection of patients for surgery.


Treatment of chronic uremia in childhood.


Human growth hormone: current knowledge regarding its role in normal and abnormal metabolic states.


Theodore C. Panos (1915-1970).

Theodore C. Panos (1915-1970).


A review of on-site visits in optometry under the New York City Medicaid Program.


Beta-galactosidase: alpha-complementation of a deletion mutant with cyanogen bromide peptides.


Initiation of protein synthesis in rabbit reticulocytes.


Nucleotide sequence specificities of guanylate residue-specific tRNA methylases from rat liver.


Inhibition of aspartokinase and N-acetylglutamokinase of Escherichia coli by hexosemonophosphates and AMP.


The action of irehdiamine A on Escherichia coli: inhibition of the membrane response at low temperatures.


Arsenate resistant mutants of Escherichia coli and phosphate transport.


Acute pancreatitis.

Acute pancreatitis.


Isolation of DD carboxypeptidase from Streptomyces albus G culture filtrates.


The activity of beta-hydroxyacyl-CoA dehydrogenase in the pancreatic islets of hyperglycaemic mice.


Emotional stress, physical activity and ischemic heart disease.


Vascular insufficiency of the bowels.

Vascular insufficiency of the bowels.


Mutants of Escherichia coli defective in the B protein of tryptophan synthetase. 3. Intragenic clustering.


Past, present and future as related to the ear, nose and throat specialty.


Factors influencing function of the autotransplanted lung.


Conjugation in Escherichia coli: interactions affecting recombination frequencies for markers situated at the leading end of the donor chromosome. Experiments have been performed to test the validity of a model which relates low recovery of very early donor markers in recombinants to the presence of sex-factor deoxyribonucleic acid at the leading end of donor deoxyribonucleic acid transferred by conjugation. This model has been found to be incorrect. The results obtained do not rule out the possibility that a piece of sex factor is transferred at the leading end, but indicate, however, that if this occurs it is not the cause of the low recovery of a very early donor marker.


Roles of acetate and pyruvate in the metabolism of Streptococcus diacetilactis. Streptococcus diacetilactis required acetate, contained acetate kinase and phosphotransacetylase, and incorporated both radioactive exogenous acetate and acetate from citrate into cell lipids. dl-alpha-Lipoic acid replaced acetate and was required for the oxidation of pyruvate. Stimulation of S. diacetilactis by citrate was found to depend on pyruvate oxidation. Resting cells of the organism produced acetate from 73% of the pyruvate they utilized. However, molar growth yields from glucose were not greater under aerobic compared to anaerobic conditions or when lipoic acid or citrate plus lipoic acid was used in the medium in place of acetate. Data indicate that the growth of S. diacetilactis is limited by the rate of acetyl-coenzyme A synthesis, that the rate of synthesis from pyruvate is higher than the rate from acetate, and that lack of acetyl-coenzyme A not required for growth limits the production of diacetyl and precludes the formation of adenosine triphosphate from acetyl-coenzyme A.


Defective excision repair of pyrimidine dimers in the ultraviolet-sensitive Escherichia coli ras- mutant. The ras(-) mutant of Escherichia coli K-12 is sensitive to ultraviolet (UV) light but only slightly sensitive to X-irradiation (1.5-fold increase). Other phenotypic properties include normal recombination ability and normal host cell reactivation ability but an abnormally high frequency of UV-induced mutation. The response of the ras(-) mutant to UV has been studied biochemically. After low doses of UV, the ras(-) mutant degraded excessive amounts of deoxyribonucleic acid, and long delays in resumption of deoxyribonucleic acid synthesis occurred. Pyrimidine dimers were excised at the normal rate. Although the mutant had the capability of initiating repair replication, the process was not completed after the high UV dose required to allow detection of repair replication. The ras(-) mutant, after low UV doses, left three to four times as many single-strand breaks not rejoined as did the wild-type strain.


Genetic mapping in Escherichia coli K-12 by radiation-induced crossing-over. Conventional methods for chromosomal mapping in Escherichia coli are (i) interruption of matings to obtain minimum marker entry times, (ii) linkage analysis of recombinants, and (iii) cotransduction. Method (i) has a resolution of about 0.5 min (5 x 10(4) nucleotides) and is not useful for distances less than about 1 min; methods (ii) and (iii) are capable of better resolution but are generally not very reproducible and no general theory is available for translating crossing-over and cotransduction frequencies into physical chromosomal distances. We found that when merozygotes are irradiated (X rays or ultraviolet light) soon after marker transfer, high linkage values (0.8 to 1.0) between nearby marker pairs decrease with radiation dose to 0.5. Our results are quantitatively consistent with the idea that radiations induce crossing-over lesions proportional to dose, and the number of such lesions between two markers is proportional to the physical separation of the markers in the range that can also be measured by interruption of mating (0.5 to 4.0 min). Additivity relations among markers are also satisfied. We used this technique to measure the distances (0.1 to 1.0 min) between several pairs of closely linked markers.


Long-term starvation survival of rod and spherical cells of Arthrobacter crystallopoietes. Spherical and rod-shaped cells of Arthrobacter crystallopoietes, harvested during exponential growth, were subjected to total starvation for periods of time as long as 80 days. Viability measurements were made by plate count and slide culture procedures. Both cell forms remained 100% viable for 30 days. Thereafter, viability of rods and spheres decreased equally at a slow rate. After 60 days of starvation, more than 65% of both cell forms were viable. No significant cell lysis occurred as evidenced by microscopic examination, the small amount of 260-nm absorbing material found in the starvation buffer, and stability of radioactively labeled deoxyribonucleic acid in the cells. Endogenous respiration decreased 80-fold during the first 2 days of starvation, accompanied by a 30% decrease in dry weight of the cells. Thereafter, cellular carbon was oxidized to CO(2) at the constant level of 0.03%/hr over the remaining 78-day starvation period.


Regulation of thymidine metabolism in Escherichia coli K-12: optimal conditions for the assay of 1,5-phosphodeoxyribomutase in ultrasonic extracts. Assay conditions have been established which allow maximum expression of phosphodeoxyribomutase activity in ultrasonic extracts of Escherichia coli K-12. The enzyme requires 2-mercaptoethanol, manganous ions, and glucose 1,6-diphosphate for optimal activity. When cells are grown in minimal medium with glycerol as the carbon source and supplemented with 10(-3)m thymidine, phosphodeoxyribomutase is induced three- to four-fold. Cell pellets may be frozen for 24 hr before sonic disruption without loss of enzyme activity. The assay is highly reproducible.


Reversion to the streptococcal state of enterococcal protoplasts, spheroplasts, and L-forms. A method is described for predetermining whether lysozyme-damaged enterococci grow as either the parent strain or as L-forms. Organisms treated with lysozyme grew as L-forms on media solidified with low concentrations of agar, or the damaged cells grew as streptococci on media solidified with high concentrations of gelatin. After induction, some of the L-forms reverted to the parent strain, but most did not during three routine subcultures. Continued spontaneous reversion occurred through approximately 30 subcultures after induction. However, subsequent progeny did not revert, even when subjected to conditions such as the gelatin medium which strongly favors growth in the streptococcal phase.


Studies on the pathway of incorporation of 2-aminopurine into the deoxyribonucleic acid of Escherichia coli. A pathway for the incorporation of 2-aminopurine into deoxyribonucleic acid (DNA) was studied in cell-free extracts of Escherichia coli. It was demonstrated that the free base can be converted to the deoxynucleoside, and that the deoxynucleotide can be phosphorylated to the di- and triphosphates and then incorporated into the DNA. From a consideration of the individual reactions in crude extracts, it is likely that the rate-limiting step in this pathway is the formation of the deoxynucleotide. Of especial interest is the observation that 2-aminopurine may be viewed as an analogue of either guanine or adenine, depending on which enzymatic step is being considered. On the one hand, it resembles guanine in that it is specifically converted from the mono- to the diphosphate by guanylate kinase and not by adenylate kinase. On the other hand, it replaces adenine rather than guanine in the DNA synthesized with purified DNA polymerases. E. coli DNA polymerase utilizes aminopurine deoxynucleoside triphosphate as a substrate for DNA synthesis much better than does purified phage T5-induced DNA polymerase and is also much less inhibited by this analogue than the T5 enzyme. These experiments in vitro correlate with known differential effects of 2-aminopurine on E. coli and phage in vivo.


Regulation of ribonucleic acid synthesis by histidine and methionine during recovery of Escherichia coli from magnesium starvation. During magnesium starvation of Escherichia coli B, most of the ribosomes break down to low-molecular-weight components. When magnesium is restored to the medium, the cells recover. The rate of recovery can be increased greatly by supplementing the growth medium with a mixture of 21 amino acids. This increased rate of recovery is shown to be due to the effect of only two amino acids, histidine and methionine, which initially stimulate accumulation of cellular ribonucleic acid without increasing the rate of protein synthesis. In contrast, histidine and methionine supplementation to logarithmically growing E. coli B is not as effective in stimulating growth as is the complete amino acid mixture. Since cells recovering from magnesium starvation preferentially synthesize ribosomes, it is possible that histidine and methionine play a special role(s) in ribosomal ribonucleic acid synthesis or stability.


Spermidine requirement for Bacillus thuringiensis ribosomes in cell-free phenylalanine incorporation. A cell-free system from Bacillus thuringiensis was found to actively incorporate phenylalanine into hot trichloroacetic acid-precipitable material in the presence of synthetic polynucleotide, ribosomes, S-100 supernatant, an energy-generating system, and guanosine triphosphate. Phenylalanine incorporation was absolutely dependent on the presence of spermidine in addition to magnesium ions, even when highly purified ribosomes were used. The spermidine effect could not be attributed to inhibition of nucleases. The ribosomal and supernatant fractions from Escherichia coli and B. thuringiensis could be substituted for each other in this system. The spermidine requirement was shown to be limited to the B. thuringiensis ribosome fraction.


Acholeplasma axanthum, sp. n.: a new sterol-nonrequiring member of the Mycoplasmatales. Mycoplasmas recovered from tissue cultures and previously shown to belong to the sterol-nonrequiring group of mycoplasmas have been further characterized. The biological and serological properties of these strains show them to be clearly distinct from Acholeplasma laidlawii and A. granularum, two species of sterol-nonrequiring mycoplasmas recently reclassified. It is proposed that the newly described mycoplasmas be designated Acholeplasma axanthum, sp. n.


Synchronous growth of enteric bacteria.

Synchronous growth of enteric bacteria. Helmstetter and Cummings devised a technique of synchronization in which cells are implanted on a membrane filter and the membrane is subjected to reverse flow of liquid medium. The cells in the effluent stream have predominantly the characteristics of newborn cells. The advantage of this technique is that the population experiences a minimum of physiological stress; hence, the behavior of the synchronous culture should reflect the normal divisional cycle. The disadvantage is that strains other than Escherichia coli B/r cannot be synchronized. We have found that a modification of the method makes it possible to synchronize several strains of E. coli, including both male and female strains, as well as Salmonella typhimurium LT2. The principal difference in technique is a prolonged period (>400 doublings) of cultivation in glucose minimal medium at 30 C and at low density (<5 x 10(6) cells/ml) prior to implantation. This precaution was taken to insure that the bacterial growth population is in a steady state of balanced growth. From the resulting synchronous growth, the distribution of interdivision times has been computed; these distributions have coefficients of variation in the range 0.18 to 0.22 and are not appreciably skewed.


Mechanism of D-cycloserine action: transport systems for D-alanine, D-cycloserine, L-alanine, and glycine. The accumulation of d-alanine, l-alanine, glycine, and d-cycloserine in Escherichia coli was found to be mediated by at least two transport systems. The systems for d-alanine and glycine are related, and are separate from that involved in the accumulation of l-alanine. d-Cycloserine appears to be primarily transported by the d-alanine-glycine system. The accumulation of d-alanine, glycine, and d-cycloserine was characterized by two line segments in the Lineweaver-Burk analysis, whereas the accumulation of l-alanine was characterized by a single line segment. d-Cycloserine was an effective inhibitor of glycine and d-alanine accumulation, and l-cycloserine was an effective inhibitor of l-alanine transport. The systems were further differentiated by effects of azide, enhancement under various growth conditions, and additional inhibitor studies. Since the primary access of d-cycloserine in E. coli is via the d-alanine-glycine system, glycine might be expected to be a better antagonist of d-cycloserine inhibition than l-alanine. Glycine and d-alanine at 10(-5)m antagonized the effect of d-cycloserine in E. coli, whereas this concentration of l-alanine had no effect.


Resistance of minicells to penicillin lysis: a method of obtaining large quantities of purified minicells. Penicillin has been used to purify large quantities of minicells.


L-Serine-sensitive mutants of Escherichia coli K-12. While attempting to isolate d-serine-sensitive mutants of Escherichia coli K-12, we found a class of mutants sensitive to low concentrations of l-serine (10 to 25 mug/ml).


Polyphasic health testing. Its service to Florida physicians.


Bringing Hippocrates to the people.

Bringing Hippocrates to the people.


Drug fears dismissed.

Drug fears dismissed.


Are ribosomes artefacts?

Are ribosomes artefacts?


Molecular biology in the year 2000.

Molecular biology in the year 2000.


Increased frequency of deletions in DNA polymerase mutants of Escherichia coli.


Elimation of the "pH effect" in cell fragility determinations.


FWR Brambell.

FWR Brambell.


Balance studies of astronauts.

Balance studies of astronauts.


The efficiency of human milk production.


Riboflavin absorption in the newborn.

Riboflavin absorption in the newborn.


Irving Leonard Ershler, M.D.

Irving Leonard Ershler, M.D.


Parkinson's disease. II.

Parkinson's disease. II.


Why automated multiphasic health testing programs?


Roentgen: the light that flickered.

Roentgen: the light that flickered.


Proceedings of the ceremony honoring Alex M. Burgess, M.D. at the Miriam Hospital, Providence, R. I. May 20, 1970.


Fifth Alex M. Burgess lecture: Alex M. Burgess and medicine: yesterday, today and tomarrow.


Vascular lesions: possible pathogenetic basis of the generalized Shwartzman reaction. Evidence of vascular injury was found in rabbits after a single small dose of endotoxin from Escherichia coli. Eighty percent of the treated animals developed circulating endothelial cells, leukopenia, and thrombocytopenia, and 50 percent had aortic endothelial lesions as determined by electron microscopy. Prior anticoagulation with heparin did not prevent this response. No control animals showed these abnormalities.


In memoriam. Lucien Y. Dyrenforth, Sr., M.D. 1895-1970.


Softening hard keratin in specimens for microscopic sections.


Evaluation of non-lactose-fermenting members of the Klebsiella-Enterobacter-Serratia division. I. Biochemical characteristics.


Philosophy of implantology.

Philosophy of implantology.


Palatal pressure areas with complete dentures.


Holographic microscopy and integrated circuit inspection.


Laser microbeam studies on tissue culture cells.


Responses in continuous cultures of lysogenic Escherichia coli following induction.


The role of aeration and agitation in the production of glucose oxidase in submerged culture. II.


Capsular protection against virulent coliphage infection.


Demonstration of host-species-specific antigens in Chlamydia psittaci by the plaque-reduction test in L-cell tissue cultures. Preliminary observations.


The response of BHK21 cells to infection with type 12 adenovirus. 3. Transformation and restricted replication of superinfecting type 2 adenovirus.


The isolation and properties of the predominant anaerobic bacteria in the caeca of chickens and turkeys.


Protoplasmic fragments in haematopoietic tissues and analysis of intranuclear vesicles in lymph node blast cells of the rabbit.


The importance of the posterior border area in the construction of the full upper denture.


Denture adhesives--a review of their uses and compositions.


Effects of altered propulsion on rat small intestinal flora.


Influence of NaCl, KCl and MgSO4 concentration on total and irreversible adsorption of T2r phage on isolated cell walls.


Elective surgery for treatment of hemorrhage from duodenal ulcer.


In memoriam, Enrico Greppi. 1896-1969.

In memoriam, Enrico Greppi. 1896-1969.


Prostaglandins and the gastrointestinal tract.


In memoriam. Martin Silberberg. 1895-1969.


Token-economy programs in the Veterans Administration.


Eumycotic mycetoma in a dog caused by Allescheria boydii.


Rabies in a raccoon.

Rabies in a raccoon.


Nuclear jaundice (kernicterus) in a newborn kitten.


Group G streptococci in the udders of a Pennsylvania dairy herd.


Fluorescent antibody and histopathologic procedures for hog cholera diagnosis.


Serratia marcescens associated with bovine abortion.


A comparison of all-meat, semimoist, and dry-type dog foods as diets for growing beagles.


Total gastrectomy and the Hunt-Lawrence jejunal pouch.


A new benzodiazepine for the treatment of emotional distress in cardiovascular disease.


The finestructure of nerve branches and neuromuscular junctions in the coxal adductor of the cockroach, Gromphadorhina portentosa.


Physiology and biochemistry of schistosomes.


Location-specificity in adult tapeworms with special reference to Hymenolepis diminuta.


Cardiopulmonary homotransplantation.

Cardiopulmonary homotransplantation.


A functional evaluation of the preserved heart.


The effect of local graft irradiation on rejection of canine cardiac allografts.


Aortic arch anomalies.

Aortic arch anomalies.


Specific binding of leucyl transfer RNA to an immature form of L-threonine deaminase: its implications in repression. The in vitro assembly of L-threonine deaminase from its constituent parts results in the formation of an inactive species of this enzyme which specifically and reversibly binds leucyl-tRNA. The native, catalytically active enzyme, which is derived from this species in the presence of maturation-inducing ligands, does not bind tRNA. The possible involvement of this protein-tRNA complex in the repression of the ilv (ADE) operon is discussed.


Transduction by bacteriophage T1.

Transduction by bacteriophage T1. Amber mutants of the virulent coliphage T1 are able to transduce a wide variety of genetic characteristics from permissive to nonpermissive K strains of Escherichia coli.


Components of histidine transport: histidine-binding proteins and hisP protein. The high-affinity (K(m) = 3 x 10(-8) M) transport system for histidine in Salmonella typhimurium has been resolved into three components: J, K, and P. J, which is a histidine-binding protein released by osmotic shock, is specified by the hisJ gene: hisJ mutants lack the binding protein and are defective in histidine transport. Another class of mutants-dhuA, which is closely linked to hisJ-has five times the normal level of binding protein and has an increased rate of histidine transport. P, which is a protein specified by the hisP gene, is required for J binding protein to be operative in transport. hisP mutants, though defective in transport, have normal levels of J binding protein. K, a third transport component, works in parallel to J, and also requires the P protein in order to be operative in transport. A second histidine-binding protein has been found but its relation to K is unclear. hisJ, dhuA, and hisP have been mapped and are in a cluster (near purF) on the S. typhimurium chromosome.


Mapping of a human genetic regulator element by somatic cell genetic analysis. The ES-2 esterase is a kidney-associated esterase and is expressed in a cloned mouse renal adenocarcinoma cell line. Somatic cell hybridization of the mouse renal adenocarcinoma with either mouse or human fibroblasts leads to the marked reduction of ES-2 esterase titer. The extinction of ES-2 esterase activity in mousexhuman hybrids is reversible. Extinction correlates with the presence of the human C(10) chromosome in the somatic cell hybrids; whereas reexpression of the ES-2 esterase is observed in hybrids which have lost C(10). Thus, the proposed regulator element involved is probably structurally linked to C(10); however, linkage to a member of the D or G groups cannot be completely excluded.


Iron: its intracellular localization and possible role in cell division. When HeLa cells are fixed with ethanol, extracted with 0.1 N HCl, and incinerated at 540 degrees C, all organic constituents and all ions studied are removed with the exception of iron. The gross outlines of cell structures are preserved and high concentrations of residual ash in interphase nucleoli and mitotic chromosomes suggest that there may be a shift in iron salts during the cell cycle. Experiments with cells isotopically labeled in proteins, nucleic acids, lipids, and polysaccharides indicate that the iron is bound to a polysaccharide. Addition of iron chelating agents to living cells causes a selective inhibition of DNA synthesis. These data suggest that iron may play a crucial role in the mitotic process.


Analysis of T4 phage proteins. I. Conversion of precursor proteins into lower molecular weight peptides during normal capsid formation. Radioisotopically labeled T4-proteins extracted from purified capsids and phage and from infected cells were separated by gel electrophoresis in the presence of sodium dodecyl sulfate and a reducing reagent. They were identified by autoradiography and by counting of the fractionated gels. Four major protein bands (F, A, D, and E) were detected in capsid and phage. These accounted for more than 90% of the total capsid protein and 70% of the phage protein (60% of the total capsid protein was in A-band). Coelectrophoresis of [(14)C]proteins from capsids and [(3)H]proteins from phage-infected cells indicated that the protein coded by gene 23 (P23) was a peptide chain approximately 25% longer than A-protein. Pulse-chase experiments combined with differential extraction indicated that conversion of P23 into A-protein and alteration of the protein coded by gene 22 (P22) appeared to be vital steps in formation of normal capsids. Mutations in several other genes known to prevent normal capsid formation inhibited conversion of P23 to A-protein and alteration of P22.


In vitro transcription of a transfer RNA gene. The Escherichia coli tRNA(Tyr) gene carried by the varphi80psu(3) + transducing phage was transcribed in vitro by DNA-dependent RNA polymerase. The enzymatically synthesized tRNA(Tyr)-like polynucleotide chains were detected by competition with purified E. coli(32)P-tRNA(Tyr) for specific hybridization sites on varphi80psu(3) + DNA. Analysis by sucrose gradient centrifugation showed the tRNA(Tyr)-like chains to possess a heterogeneous distribution with respect to sedimentation coefficients, with a broad peak around 8 S. The presence of the termination factor rho during the transcription did not significantly reduce the average size of the in vitro synthesized tRNA(Tyr)-like chains.


Ventilation-perfusion ratio during intermittent positive-pressure ventilation. Importance of no-flow interval during the insufflation.


A new outbreak of infantile diarrhoea caused by pathogenic E. coli.


Plasma skimming in the intestinal tract.


Normal flora--rumen bacteria.

Normal flora--rumen bacteria.


Normal fecal flora of man.

Normal fecal flora of man.


Gnotobiology is ecology.

Gnotobiology is ecology.


Factors influencing the establishment of the neonatal bacterial flora. II. The role of environmental factors.


Dr. Sam. IX. A door opens.

Dr. Sam. IX. A door opens.


The hospital environment--a crossroads for infection.


Growth of organs from mice with leukemia induced by the Graffi virus in in vitro cultures.


The effects of variations of inspiratory flow waveform on cardiorespiratory function during controlled ventilation in normo-, hypo- and hypervolaemic dogs.


The pressures exerted on the trachea by endotracheal inflatable cuffs.


Alterations in response to somatic pain associated with anaesthesia. XIX: Studies with the drugs used in neuroleptanaesthesia.


A review of the structural and functional basis of laryngospasm and a discussion of the nerve pathways involved in the reflex and its clinical significance in man and animals.


Biochemical and pharmacological studies with asparaginase in man.


An immunological barrier in the guinea-pig testis.


AFL-CIO fact sheet on chiropractic.

AFL-CIO fact sheet on chiropractic.


Vitamin A physiology.

Vitamin A physiology.


Studies on rumen metabolism. VI. In vitro hydrolysis of triglyceride and isolation of a lipolytic fraction.


How about your kidneys, doctor?

How about your kidneys, doctor?


Williams C. Cruikshank (1745-1800) surgeon of Leicester Square.


De novo gene duplication versus reactivation of cryptic genes in Escherichia coli K-12.


Evidence for an early regulatory function in Phage P22.


Host specificity of DNA produced by Escherichia coli. XII. The two restriction and modification systems of strain 15T-.


Cell division of the Escherichia coli lon- mutant.


Priority of nutrition in national development.


Insulin, glucose, and carbohydrate nutrition in hyperlipoproteinemias.


L-asparaginase in cancer therapy.

L-asparaginase in cancer therapy.


Zinc in hair as a measure of zinc nutriture in human beings.


Iodine fortification and thyrotoxicosis.


Lipogenesis from carbohydrate--an energy-yielding process for the adipose cell.


The feeding center and body weight regulation.


The effect of polyinosinic:polycytidylic acid on tumor metabolism.


Effect of amino acid levels on a cell-free system for protein synthesis.


Unconjugated bilirubin transport in normal and mutant Corriedale sheep with Dubin-Johnson syndrome.


The cardiac lymphatics after ligation of the coronary sinus.


Sedimentation analysis of the cells in mice required to initiate an in vivo immune response to sheep erythrocytes.


Immunosuppressive agents in protein-losing nephritis.


The transducer action of the cochlea: some recent advances.


The biosynthesis of protein by liver ribosomes.


Control of the anterior pituitary gland by hypothalamic releasing-factors.


Proteinuria.

Proteinuria.


The long-acting thyroid stimulator.

The long-acting thyroid stimulator.


The regulation of cholesterol metabolism as related to familial hypercholesterolaemia.


Control of body temperature in newborn babies.


Vitamin D deficiency after gastrectomy.

Vitamin D deficiency after gastrectomy.


Recent advances in the study of rubella.


Tumour growth and curability.

Tumour growth and curability.


Antigen competition: a paradox.

Antigen competition: a paradox. Immunization of mice with pig erythrocytes caused impairment of the antibody response to subsequent immunization with sheep erythrocytes, a phenomenon called "antigen competition." Paradoxically, spleen cells from mice previously injected with pig erythrocytes produced an increased response when immunized in vitro with sheep erythrocytes. Augmentation of the in vitro response is due to an increase in one of the interacting cell types. "Antigen competition" is not due to competition for cells. Cell transfer experiments provided evidence that "antigen competition" observed in animals is the result of a humoral factor, presumably antibody, present in the animal but eliminated during preparation of cells for culture.


Antigen-binding cells in normal mouse thymus. The thymus of a normal adult mouse contains lymphocytic cells with a large number of antigen-binding receptors. Binding of the antigen by these cells is specific and can be inhibited by cross-reactive materials. It is possible that the interaction of thymocytes with antibody-forming precursor cells, required in the primary immune response to certain antigens, is mediated by these specific antigen-binding cells of the thymus.


Fermentation processes employed in vitamin C synthesis.


Collection of microbial cells.

Collection of microbial cells.


The occurrence, chemistry, and toxicology of the microbial peptide-lactones.


History of the development of a School of Biochemistry in the Faculty of Technology, University of Manchester.


Microbial metabolites as potentially useful pharmacologically active agents.


McCollum Award. Dr. William H. Crosby.

McCollum Award. Dr. William H. Crosby.


Flavor and microorganisms.

Flavor and microorganisms.


Neurologic disorders seen in the uremic patient.


Anemia of chronic renal disease.

Anemia of chronic renal disease.


Effects of neonatal malnutrition on developing cerebrum. I. Microchemical and histologic study of cellular differentiation in the rat.


Effect of neonatal malnutrition on developing cerebrum. II. Microchemical and histologic study of myelin formation in the rat.


Striatonigral degeneration. Clinical-pathological correlations and response to stereotaxic surgery.


Activation of experimental epileptogenic foci. Action of increased K+ in extracellular spaces of the brain.


Johannes Maagaard Nielsen.

Johannes Maagaard Nielsen.


The phylogeny of the ribonuclease-ribonuclease inhibitor system: its distribution in tissues and its response during leukaemogenesis and aging.


Motility in procaryotic organisms: problems, points of view, and perspectives.


Glycoproteins in membranes.

Glycoproteins in membranes.


Further studies of the effect of bone marrow cells on chemically induced lymphoma in C57BL-6 mice. Injection of syngeneic bone marrow cell to adult C57BL/6 mice treated DMBA intragastrically failed to prevent lymphoma induced by the chemical.The present result seem to indicate that bone marrow cells do not hasten the regeneration of the transient injuried thymus by DMBA as compared with their effect in irradiated mice.IT APPEARS THAT, UNDER THE CONDITIONS USED, DMBA DOES NOT CAUSE SIGNIFICANT DAMAGE TO THE BONE MARROW SINCE MARROW CELLS FROM CHEMICALLY TREATED MICE WERE AS EFFECTIVE AS NORMAL MARROW CELLS IN: (a) preventing radiogenic leukaemia, (b) repairing radiation damage of the thymus, (c) preventing the lethal action of high doses of irradiation.Marrow cells failed to restore antibody formation to Shigella depressed by DMBA as they do in irradiated mice.The result strengthen our previous view on the critical role of bone marrow on the effects caused by irradiation and not in the leukaemia process as such.


The epidermis and the respiratory tract as bioassay systems in tobacco carcinogenesis. In tobacco carcinogenesis research, considerable attention has been paid to the choice of the bioassay. The ideal system should simulate the human smoking setting as closely as possible and should utilize tissue of a type similar to that found at the sites where the tobacco smoke-related cancers originate in man. However, although certain inhalation experiments in the laboratory meet these requirements to some extent, they are generally timeconsuming and difficult to evaluate and since they usually have to be performed on large animals, are extremely costly when used for the identification of the actual tumorigenic agents in the smoke.The present article examines the reasons why mouse skin is a useful bioassay. The system has enabled investigators to identify tumour initiators and accelerators and to determine that the major tumour promoters reside in the weakly acidic portion of tobacco smoke. The mouse skin bioassay demonstrated that with significant inhibition of the pyrosynthesis of alkylated and non-alkylated polynuclear aromatic hydrocarbons, the tumorigenicity of the "tar" will also decrease significantly.


Erythropoiesis in murine myeloid leukaemia. Erythropoiesis during the development of myeloid leukaemia in mice was studied, using assay of radio-iron incorporation in blood, exorepopulation and autorepopulation techniques. These tests indicated a certain tendency of decreasing erythropoiesis during the leukaemic process due to declining numbers of the normal erthropoietic cell precursors.


Wound contraction in rabbits and the effectiveness of skin grafts in preventing it.


Contribution to the origin of the vasculature in free skin autografts.


Persistence of active donor follicles after skin allograft rejection by hamsters.


Oesophagoplasty with penile skin.

Oesophagoplasty with penile skin.


A method of treating chronic flexion contractures of the fingers.


Staghorn calculi of the kidney: clinical bacteriological and biochemical features.


John Dawson (1734-1820).

John Dawson (1734-1820).


Mixed venous oxygen saturation in relation to cardiac output in myocardial infarction. Mixed venous oxygen saturations derived from measurement of mixed venous oxygen tension were compared with dye dilution cardiac output determinations in 26 patients with acute myocardial infarction. Mixed venous oxygen saturation was greatly reduced in patients with shock or failure complicating myocardial infarction. The level of oxygen saturation correlated with cardiac output determinations. The measurement of mixed venous oxygen saturation, which is relatively simple and does not require elaborate equipment, should be an important aid to the rational treatment of patients with low output states complicating acute myocardial infarction.


Lung transplantation.

Lung transplantation.


Comparative trial of tetracycline, chloramphenicol, and trimethoprim-sulphamethoxazole in eradication of Vibrio cholerae El Tor. A comparison of tetracycline, chloramphenicol, and trimethoprim/sulphamethoxazole showed that all hasten the eradication of Vibrio cholerae from the stools of patients with cholera.A four-day period of tetracycline or trimethoprim/ sulphamethoxazole was adequate for eradicating V. cholerae from the stools of all patients, but three days, as suggested by the W.H.O. Expert Committee, was not. Four days of chloramphenicol therapy was sufficient for most patients, but a minority required up to seven days' therapy.Purging produced reappearance of V. cholerae in the stools of one-eighth of the patients who had had three successive daily negative stool cultures; such patients are a potential danger to the population.


A ribosomal-bound aminopeptidase in Escherichia coli B: purification and properties.


Intravital nontoxic sulfide loading of synaptic zinc in hippocampus.


Acridine treatment of F+ and Hfr strains of Escherichia coli K12 carrying a neomycin-kanamycin resistance determinant.


Medicare and extended care facilities.

Medicare and extended care facilities.


A double-blind study of ipodate and the non-diagnostic cholecystogram.


Estimation of bacterial numbers in urine: a simplified dilution method.


Observations on the coagulase and deoxyribonuclease tests for staphylococci.


A system for the classification of materials and information on histopathological material.


An atraumatic rectal swab for small laboratory animals.


Reflected-light differential-interference microscopy: principles, use and image interpretation.


A filtration technique for preparing cells in suspension for electron microscopy.


Orientation of spherical specimens for ultrathin sectioning in selected planes by embedding in agar.


Acomparative trial of  A/Howard HI: A comparative trial of "Slow-Fe" and ferrous sulphate B.P.


The use of sustained release lithium carbonate in general practice. A pilot study.


Child psychotherapy--help or hindrance?

Child psychotherapy--help or hindrance?


Studies on the mutability of Escherichia coli K12. II. Modification of radiation sensitivity by reversions in a threonine auxotroph.


Protection against lethal effects of ultraviolet light on Escherichia coli by capsular polysaccharide.


Studies on the mutability of Escherichia coli K12. I. Suppression and high spontaneous mutation in a threonine auxotroph.


The Health Ideation Pictures (HIP): reliability and internal consistency.


Variance in size of drawing in a psychotic population.


Learning impairment in schizophrenic and brain-damaged patients.


The aim and philosophy of patient monitoring.


Experimental studies with a clinical monitor and diagnostic computer.


Respiratory manifestations of rheumatoid arthritis.


2,4,4'-Trichloro-2'-hydroxydiphenyl ether, a new antimicrobicum, and its importance in the washing of hospital laundry.


Phenylketonuria: a review.

Phenylketonuria: a review.


A rapid radioactive assay for glutamine synthetase, glutaminase, asparagine synthetase, and asparaginase.


A lysozyme assay method for low activity.


Trends in clinical neuroendocrinology.

Trends in clinical neuroendocrinology.


The literature of ethical problems in medicine. 3.


Pathophysiology and therapy of the shock of myocardial infarction. This literature review selects basic science and clinical papers that discuss the pathophysiology and therapy of cardiogenic shock.  Cardiogenic shock results from decreased coronary blood flow.  This decreased flow lowers the tension of myocardial oxygen and raises the concentration of myocardial depressant metabolites, reducing contractile strength and cardiac output.  When presented with cardiogenic shock, an effort should be made to raise oxygen tension and decrease metabolite concentration.  This can be done by improving coronary blood flow, but other routes to the same ends include restoration of normal arterial oxygen use and metabolite production.  If oxygenation proves insufficient, an agent must be used which directly stimulates myocardial strength, it is important to choose a drug that does not further aggravate the already disproportionate difference between oxygen delivery and use.  (Digitalis is the agent of choice, followed by metaraminol and levarterenol; isoproterenol should not be used.) An increase in strength at the expense of a further reduction in myocardial oxygen tension and a further increase in the concentration of myocardial depressant metabolites can only lead to a decreased chance of survival.


Metastatic basal cell carcinoma. A review.


The alveolar wall.

The alveolar wall.


A controlled trial of inverting versus everting intestinal suture in clinical large-bowel surgery.


Serum lymphocyte cytotoxic titre responses in the mouse following injection of viable and dead human lymphocytes by varying routes and in differing doses, and the effect of Freund's adjuvant.


Human thoracic duct drainage.

Human thoracic duct drainage.


The antilymphocytic serum (ALS) effect and the adrenal cortex in rats.


Prolonged survival of renal allografts exchanged between two incompatible strains of rat.


The effect of Escherichia coli endotoxin on membrane permeability in skeletal muscle.


Problems in studies of human exposure to air pollutants.


On the discovery and chemistry of neuraminic acid and gangliosides.


Chemistry of sphingolipids; some historical aspects.


Enzymatic aspects of sphingolipid degradation.


Chemistry of gangliosides.

Chemistry of gangliosides.


Gas chromatographic and mass spectrometric studies of synthetic and naturally occurring ceramides.


Institutional management of chronic schizophrenics with fluphenazine decanoate.


Depot fluphenazine in the treatment of psychosis in a community mental health clinic.


Experience of psychiatric management of schizophrenia with fluphenazine decanoate.


Fluphenazine hydrochloride, enanthate, and decanoate in the management of chronic psychosis.


Symposium on long-acting phenothiazines in psychiatry. Bibliography.


Characteristics of electrogenic sodium pumping in rat myometrium. Sodium-rich myometrium, obtained from the uteri of pregnant rats, rapidly hyperpolarized when 4.6-120 mM potassium was added to the bathing medium at 37 degrees C. Hyperpolarization was due to sodium pumping since the process was markedly temperature dependent, was abolished by ouabain, and required both intracellular sodium and extracellular potassium. The observed membrane potential exceeded the calculated potassium equilibrium potential during hyperpolarization providing evidence that sodium pumping was electrogenic. Hyperpolarization was reduced in the presence of chloride. The rate of sodium pumping may influence potassium permeability since potassium apparently did not short-circuit the pump during hyperpolarization.


The normal flora of ileostomy and transverse colostomy effluents.


Transmission of chloramphenicol-resistant Staphylococcus epidermidis: epidemiologic and laboratory studies.


A ten-year study of bacteriuria in schoolgirls: final report of bacteriologic, urologic, and epidemiologic findings.


Analysis of the virulence of Shigella flexneri by experimental infection of the rabbit eye.


Immediate pharyngeal repair after pharyngo-laryngectomy using the medially based chest flap.


A review of Soviet viral hemorrhagic fevers, 1969.


The role of hemoglobin for the lethal effect of intestinal strangulation fluid.


Experimental infection of mice with Mycobacterium leprae hominis: additional data.


Tumor immunity.

Tumor immunity.


The action of fluocinolone acetonide upon scar tissue formation.


Urinary tract infection and renal homotransplantation. IV. The bladder defense mechanisms involved in bacteriuria in donors.


Scrotal flap repair of neo-rectal stenosis following the Gersuny procedure.


The efficacy of imipramine in the management of enuresis.


Bibliography on antibiotics published in foreign countries. 81.


Comparative morphology and immunology of members of the genus Histoplasma. A review.


Medicine and the computer. The promise and problems of change.


James Curtis Hepburn, M.D., 1815-1911 ("Hepburn of Japan").


The columnar epithelial cell of the small intestine: digestion and transport. II.


Charles G. Hayden (1911-1970).

Charles G. Hayden (1911-1970).


Malaria: introduced vs. imported.

Malaria: introduced vs. imported.


Smallpox data by Dr. Uplavici?

Smallpox data by Dr. Uplavici?


Bacterial content of semen, collected by artificial vagina, from bulls that evert the preputial epithelium.


Functional and morphological studies of islet beta-cell regeneration in endogenous and exogenous diabetes.


Hyperacute kidney rejection in rabbits with lymphocytotoxic antibodies.


Fluorescent EBV antibodies in infectious mononucleosis.


The future of cytogenetics.

The future of cytogenetics.


Growth rates and virulence of E. coli in exudates produced during intestinal strangulation obstruction in rats.


On the antigenic structure of Toxoplasma gondii. 1. Preliminary results of antibody absorption experiments.


Regulation of metabolic processes in brown adipose tissue in relation to nonshivering thermogenesis.


Rate control of the tricarboxylic acid cycle.


Dermal arthroplasty.

Dermal arthroplasty.


Induction of antinuclear antibodies by ultraviolet irradiation.


Assessment of clinical methods of evaluation and isotope techniques in analgesic trials in rheumatoid arthritis.


FTA-ABS test (using Reiter sonicate and "sorbent") in comparison with other serologic tests for syphilis.


Mechanisms and stereochemistry in fatty acid metabolism.


Immuno-histopathology of the skin in pemphigoid.


Review of the German dermatological literature 1968.


Catabolite repression of the lac operon. Effect of mutations in the lac promoter. 1. Several lac diploid strains of Escherichia coli were constructed and tested to discover whether mutations in the lac promoter alleviate catabolite repression. 2. In each of these diploids the chromosome carries one of the promoter mutations, L8, L29 or L1; so that the rate of synthesis of the enzymes of the lac operon is only 2-6% of the fully induced wild-type. Each diploid harbours the episome F'lacM15 that specifies the synthesis of thiogalactoside transacetylase under the control of intact regulator, promoter and operator regions, but has a deletion in the structural gene for beta-galactosidase. In each diploid more than 90% of the thiogalactoside transacetylase is synthesized from the episome, and 100% of the beta-galactosidase is synthesized from the chromosome, and comparison of the extent of catabolite repression that the two enzymes suffered indicated whether the chromosomal promoter mutation relieves catabolite repression. 3. In the strains in which the promoter carries either of the point mutations L8 or L29 the enzymes were equally repressed, suggesting that neither L8 nor L29 affects catabolite repression. 4. In a diploid strain harbouring the same episome but carrying deletion L1 on the chromosome, synthesis of beta-galactosidase suffered much less repression than that of thiogalactoside transacetylase. 5. In a diploid strain in which the chromosome carries L1 and also a second mutation that increases the rate of expression of lac to that permitted by L8 or L29, the synthesis of beta-galactosidase again suffered much less repression than the synthesis of thiogalactoside transacetylase. 6. The effect of L1 (which deletes the boundary between the i gene and the lac promoter) is ascribed to its bringing the expression of lac under the control of the promoter of the i gene. 7. Even in strains carrying L1, some catabolite repression persists; this is not due to a trans effect from the episome since it occurs equally in a haploid strain with L1.


Granuloma pyogenicum.

Granuloma pyogenicum.


[Contact dermatitis. XII. Unresponsiveness to contact sensitizers in man].


Bone-graft surgery reappraised: the contribution of the cell to ultimate success.


The value of a combined pentagastrin-insulin test in studies of stomal ulceration.


Experimental therapeutic approaches to peptic ulcer.


Increase in antibody titer against the EBV-associated membrane antigen complex in Burkitt's lymphoma and nasopharyngeal carcinoma after local irradiation.


Fine structure of endometrial stromal sarcoma.


Cervical dysplasia and cancer developing in women on immunosuppression therapy for renal homotransplantation.


Lymphosarcoma cell leukemia. A clinicopathological study.


Clinical experience with procarbazine in Hodgkin's disease, reticulum cell sarcoma, and lymphosarcoma.


Origin of chromosomal abnormalities in nuclear transplants--a reevaluation of nuclear differentiation and nuclear equivalence in amphibians.


Transposition of the great arteries and of the pulmonary veins including an account of cardiac embryology and chamber identification.


A comparison of pigment cell development in albino, steel, and dominant-spotting mutant mouse embryos.


Highlights of complement research during the past twenty-five years.


A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide. The haematological effects of long-term treatment for three months with a combination of trimethoprim and sulphamethoxazole were studied in 10 cases of chronic bronchitis. Trimethoprim selectively inhibits dihydrofolate reductase in bacteria but not in man. Only minor effects on folate metabolism were observed in nine cases, causing no clinical concern. Some degree of thrombocytopenia occurred in the tenth case which improved when folinic acid was given.


Gastrointestinal lymphoma in childhood.

Gastrointestinal lymphoma in childhood. Thirteen cases of lymphoma of the bowel in infancy and childhood are presented. There is a marked preponderance in males. The tumour most commonly presents with abdominal pain and intestinal obstruction; the prognosis is poor. Histological findings characteristic of the ;Burkitt' type of lymphosarcoma do not apparently influence survival.


Chronic biological false-positive reactions to serological tests for syphilis in blood donors. Problem sera from 375 blood donors were investigated for biological false-positive reactions to serological tests for syphilis. Problem sera are those sera in which submitting laboratories have found a reactive result to a screening test for syphilis. On each serum a cardiolipin Wassermann reaction, a Venereal Disease Research Laboratory test, a Reiter protein-complement fixation test, a Treponema pallidum immobilization test, and a fluorescent treponemal antibody absorption test were performed. Of the sera 49.9% were found to be non-reactive in all five tests, 28.8% gave results indicating a diagnosis of syphilis, and 21.3% showed biological false-positive reactions. There were 80 sera from blood donors which gave biological false-positive reactions. A further specimen of serum from 67 of these donors was tested after an interval of a minimum of six months. Sixty-six of the sera showed chronic biological false-positive reactions. Some donors were only found reactive for the first time after they had given very many donations of blood. It is concluded that sudden blood loss, as in blood donation, appears to stimulate the production of excess reagin in certain individuals, causing a chronic biological false positive reaction to serological tests for syphilis. This may only appear after several blood donations have been made.


Improved processing technique for renal biopsies for light microscopy.


Treatment of nocturnal enuresis with preludin.


Heretical taxonomy for bacteriologists.

Heretical taxonomy for bacteriologists.


The sensitivity of gram-negative bacteria, recovered from aerosols, to lysozyme and other hydrolytic enzymes.


Analysis of an R+ strain carrying two fi- sex factors.


A method of classifying solid leprosy bacilli based on the number of band structures on them.


Explanation of the apparent association of host specificity determinants with fi+ R factors.


In defense of the name "leprosy".

In defense of the name "leprosy".


Clinical stages in sulfone treatment of leprosy.


Iatrogenic deafness.

Iatrogenic deafness.


Polypeptide products of nonsense mutations. I. Termination fragments from nonsense mutations in the Z gene of the lac operon of Escherichia coli.


P1-like plasmid in Escherichia coli 15.

P1-like plasmid in Escherichia coli 15.


Crypticogenicity of bacteriophage lambda.


Annie Jean Macnamara.

Annie Jean Macnamara.


Bacteriological and urinary findings in adolescent Egyptian males with and without urinary schistosomiasis.


Walter Ernest Isaac Summons.

Walter Ernest Isaac Summons.


Enzyme evolution: generation of a bifunctional enzyme by fusion of adjacent genes.


Evaluation of drainage procedures combined with vagotomy.


Antilymphocytic serum--the possible clinical applications.


Occasion for an international view. The Society's Golden Jubilee--1920-1970.


Growing points in cell pathology. Histochemical aspects.


Two steps--a radiographer's story.

Two steps--a radiographer's story.


On a new kind of rays. By W.C. Rontgen. Translated by Arthur Stanton from the Sitzungsberichte der Würzburger Physic-medic. Gesellschaft, 1895. Nature, January 23, 1896.


Professor Rontgen's discovery. By A.A.C. Swinton. Nature, January 23, 1896.


Origin of British x-ray film sizes.

Origin of British x-ray film sizes.


A subtraction technique with rapid-cycle film and processing.


Looking back.

Looking back.


Studies of the variability in expiratory efforts before and after cholecystectomy.


The mechanics of laryngeal function.

The mechanics of laryngeal function.


The effect of intraocular surgery on clear corneal grafts.


A double-blind study of fluorometholone.


Orbital volume following evisceration, enucleation, and exenteration in rabbits.


Advances in socket reconstruction.

Advances in socket reconstruction.


Roger James Morrison.

Roger James Morrison.


Radiological aspects of severe asthma.

Radiological aspects of severe asthma.


The archives of the College. Guide to the Herbert Roy Sear Collection.


Amounts of free 70S ribosomes and ribosomal subunits found in Escherichia coli at various temperatures.


RNA as a template with E. coli DNA polymerase.


DNA-RNA hybridization at low temperature in the presence of urea.


Effect of carbohydrates on induction of bacteriophage lambda.


Localization of streptolydigin resistant mutation in E. coli chromosome and effect of streptolydigin on T2 phage development in stl-r and stl-s strains of E. coli.


Factor dependent breakdown of polysomes.


A possible function of DNA polymerase in chromosome replication.


UGA nonsense suppression assayed by T4 DNA-dependent in vitro synthesis of lysozyme.


Treponema pertenue under the electron microscope.


Immunofluorescence investigations of antibodies against treponemal group antigen.


Fluorescent treponemal antibody-absorption (FTA-ABS) test in patients with aortic valvular insufficiency.


Skin biopsy in cases of secondary syphilis.


Treatment of acute gonococcal urethritis with three drug regimes in 768 males, Brisbane, Queensland, 1967-69.


Review: antigens and viruses in acute hepatitis.


Cytochemical studies of skeleton neoplasms.


Applied aspects of microbial genetics.

Applied aspects of microbial genetics.


Cytochemical demonstration of acid phosphatase and non-specific esterases as a means of identification and estimation of differentiation of human lymph node cells.


Mitotic division of the cells of the islets of Langerhans.  Effect of liver damage and effect of hyperglycaemia and exhaustion of insulin reserves.


The relation between radiation stability and DNA replication of phage T4.


Fate of adenovirus types 2 and 12 in infected serial cultures of non-primate origin.


Identification of a 5 s RNA precursor in exponentially growing Escherichia coli cells.


Non-chromosomal antibiotic resistance in bacteria. II. Molecular nature of R-factors isolated from Proteus mirabilis and Escherichia coli.


Secondary structure of bacteriophage f2 ribonucleic acid and the initiation of in vitro protein biosynthesis.


Intracellular pools of bacteriophage lambda deoxyribonucleic acid.


Middle Tennessee medicine 75 years ago.

Middle Tennessee medicine 75 years ago.


Clinical and heuristic value of clinical drug research.


Hereditary deafness with external-ear abnormalities: a review.


Prazosin hydrochloride (CP-12,299-1), an oral anti-hypertensive agent: preliminary clinical observations in ambulatory patients.


A double-blind intensive crossover design trial of methysergide in mania.


Prognosis and early management in breast cancer.


Clinical evaluation of an oral analgesic, Z.424, in patients with chronic pain.


Bacchus transported. Purporting to be an historical impression of alcoholism in Australia.


Helen Turner Field.

Helen Turner Field.


Robert Lanktree Withers.

Robert Lanktree Withers.


The pill and the breast.

The pill and the breast.


Russell David King.

Russell David King.


Modified classification of purity degrees of the vagina. Importance of culture assays.


Behavioral regulation of body temperature in poikilotherms.


Experimental biliary pancreatitis in dogs. Demonstration of proteolytic activity in pancreatic tissue extracts and interference of dog serum constituents with proteolytic enzymes. Introduction.


Intra-osseous anchorage of dental prostheses. II. Review of clinical approaches.


The effects of hyperbaric oxygen, dimethyl sulfoxide and Complamin on the survival of experimental skin flaps.


Advanced kidney disease in patients with hepatosplenic Manson's schistosomiasis.


The effect of rest and physical effort on the left ventricular burden in mitral and aortic regurgitation.


The cross-linking of collagen and elastin and its inhibition in osteolathyrism. Is there a relation to the aging process?


An old-fashioned approach to acid-base balance.


Comparative studies on fresh and preserved skin: fundamental biologic differences in behavior as grafts.


Fulminatingly progressive recurrent glomerulonephritis in a renal allograft.


Acute effects of autotransplantation on pulmonary vascular resistance and blood-gas exchange in the canine lung.


Aerosol therapy in cystic fibrosis.

Aerosol therapy in cystic fibrosis.


A review of phenacetin toxicity in animals.


Epidemic infantile gastro-enteritis today.


Preliminary studies in nervous conduction through myelomeningocele lesions.


Dilatation of the renal tract in children with neurospinal dysraphism.


Mechanical ventilation in the respiratory distress syndrome: a controlled trial.


Kidney biopsy in the hepatosplenic form of infection with Schistosoma mansoni in man. A study of early glomerular lesions was made in 8 patients infected with Schistosoma mansoni but having no clinical evidence of renal disease. Electron-microscopy of renal biopsies showed the presence of electron-dense deposits in basement membranes and of laminated bodies near the mesangial cells. Immunofluorescence showed that the deposits corresponded to IgG in 8 cases and to IgM in 2 cases. These lesions are comparable with those found in the kidneys of patients with cirrhosis of the liver.


Practical applications of new laboratory methods for plague investigations.


The value of a genetic expression of leucocyte typing in renal transplantation.


Correlation between mixed lymphocyte culture performed before renal transplantation and kidney function.


Thymectomy and renal homotransplantation.


Characterization of two different types of direct plaque-forming cells.


Renal disease in (NZB x NZW) F1 mice treated with antilymphocytic antibody. II. Effects of restoration with isogeneic, allogeneic, and xenogeneic lymphoid cells.


Auto-antibodies of the IgD class.

Auto-antibodies of the IgD class.


Effect of secretin on gastric acid secretion in response to cholinergic stimuli.


Assay of two pepsin fractions in human gastric juice by alkali inactivation.


Alcian blue binding properties of gastric juice.


Progress in gastroenterology. The esophagus: 1967 to 1969. II.


Philip Hudson Macindoe.

Philip Hudson Macindoe.


Chronic renal disease: a socio-economic study.


Amantadine hydrochloride in the treatment of Parkinsonism. A controlled trial.


John Forbes MacKenzie.

John Forbes MacKenzie.


Amantadine hydrochloride in the treatment of Parkinson's disease.


Eperythrozoon ovis--a blood parasite of sheep.


Benign condition simulating malignancy in celiac arteriography.


Studies on the in vivo breakdown of insoluble halides.


Replica analysis of the class of antibodies produced by single cells.


Nucleases in immunity. I. The effect of immunization on RNase and DNase activity in lymphoid tissues.


Depletion of long-lived lymphocytes in old New Zealand black mice.


The establishment of tolerance in adult anaemic mice of the W-series treated with anti-lymphocytic serum and allogeneic haemopoietic cells.


Nucleases in immunity. II. Ineffectiveness of exogenous RNase on the antibody plaque response of immunized mice.


In vitro cytotoxicity by human lymphocytes from individuals immunized against histocompatibility antigens. II. Relation to HL-A incompatibility between effector and target cells.


L-asparaginase: suppression of the immune response of mice to sheep red blood cells.


Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance.


Experimentally produced antibodies to the pepsin site of IgG due to untreated autologous IgG in immune complexes.


Modulation of the immune response by a methanol-insoluble fraction of attenuated tubercle bacilli (BCG). I. Primary and secondary responses to sheep red blood cells and T2 phage.


An efficient one-visit impression technique for gold-post and cast crown fabrication.


The response of normal, thymectomized and reconstituted mice in contact sensitivity.


Implications of congenital ophthalmoplegia for the development of visuo-motor functions (illustrated by a case with the Moebius syndrome).


Time-dose relationships in radiotherapy.


Studies on the cellular and molecular mechanisms of hydrocarbon carcinogenesis.


The microflora of the pig stomach and its possible relationship to ulceration of the pars oesophagea.


Clinical pathology of ostertagiasis in calves during prolonged experimental infection.


Observations on the functional integrity of neutrophil leucocytes infected with tick-borne fever.


The relationship between the mandibular incisor teeth and the lower lip.


[Dr. Boucher receives the Callahan Award].


Skin grafting alveoloplasty following resection of intraoral tumors.


Compensating for shrinkage of gold in cast crowns.


American Board of Prosthodontics.

American Board of Prosthodontics.


The current status of electrogastrography.


Inhibition of the cytoaggressive effect of phytohaemagglutinin (PHA)-stimulated human lymphocytes by E. coli L-asparaginase (EC-2 A-SE).


Studies on the pressure dressing in full-thickness skin grafting. II. Observations on rabbit skin autografts.


Trial of a new hypotensive drug--clonidine ("catapres").


Scale for the measurement of attitudes toward physicians and primary medical care.


Cell interaction in an immune response in vitro: requirement for theta-carrying cells. Cytotoxic antiserum to theta antigen reduces the capacity of mouse spleen cells to generate direct and indirect plaque-forming cells to sheep erythrocytes in vitro but does not affect plaque-forming cells, their precursors, or hemopoietic stem cells. The response of spleen cells treated with antiserum to theta antigen is restored by thymus cells incubated in vivo with sheep erythrocytes.


Enzyme specificity as a factor in regulation of fatty acid chain length in Escherichia coli. Various acyl-acyl carrier protein intermediates in saturated and unsaturated fatty acid biosynthesis were tested as substrates for beta-ketoacyl-acyl carrier protein synthetase. With both classes of substrates the condensing enzyme in fatty biosynthesis demonstrates specificities which indicate that it might be an important factor in determining fatty acid chain length in Escherichia coli.


Tumor immunity produced by the intradermal inoculation of living tumor cells and living Mycobacterium bovis (strain BCG). The intradermal inoculation of mixtures containing living tumor cells and living Mycobacterium bovis (strain BCG) into unimmunized syngeneic guinea pigs results in an inflammatory reaction to the BCG, and there is no progressive tumor growth. In the absence of BCG the tumor grows progressively, metastasizes, and kills the animal. By conventional methods, it has not been possible to immunize syngeneic guinea pigs to the tumor used. Guinea pigs that receive mixtures of BCG and tumor cells, however, develop specific systemic tumor immunity as measured by delayed cutaneous hypersensitivity and by suppression of tumor growth.


Homer Northup Calver, 1892-1970.

Homer Northup Calver, 1892-1970.


Bacteria in laundered fabrics.

Bacteria in laundered fabrics.


The effect of hypophysectomy on the gastrointestinal tract. A review of the literature.


Solvent extraction of transfer ribonucleic acids.


Turbidity measurements of bacterial cultures in some available commercial instruments.


Blast cell leukaemia associated with IgA paraproteinaemia and Bence Jones protein.


HL-A antigens on leukaemic cells.

HL-A antigens on leukaemic cells.


Enzymic dissection of cerebral cortex synapses.


Cultivation of isolated nerve cells in a perfusion chamber and the early effects of nerve growth factor on them.


A double isotope dilution method for differential determination of adrenaline and noradrenaline in plasma.


Electron microscopy of teased nerve fibers: method permitting examination of repeating structures of same fiber.


On the contribution of the Würzburg school to the study of thought processes.


Intracranial resistance measurements.

Intracranial resistance measurements.


Chloramphenicol with streptomycin, chloramphenicol with broxyquinoline and brobenzoxaldine suspension in diarrhoeas.


A review of occupational cancer.

A review of occupational cancer.


Effects of septal stimulation on escape from dorsal midbrain aversive stimulation.


Laboratories approved for serologic tests for syphilis.


The columnar epithelial cell of the small intestine: digestion and transport. 3.


The administration of large doses of ascorbic acid in the prevention and treatment of the common cold. II.


A comparison of oxypertine and chlorpromazine in chronic schizophrenia.


On some pigments of Epicoccum nigrum Link: their isolation and structure elucidation and a biosynthetic pathway of rhodoxanthin.


Grindstones and grindstone makers one hundred years of grindstone making.


History and psychiatry's present state of transition.


Biological properties of Shigella sonnei endotoxins.


Studies on the effect of triphosphates of 5-aminouridine and 5-hydroxydeoxyuridine on ribonucleic acid and deoxyribonucleic acid polymerases.


L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.


The culture of goldfish cells (Carassius auratus) at high temperatures.


Heat-labile natural anti-digestive antibodies in animals.


The action of hormones in insect cell and organ cultures.


A therapeutic trial in migraine with parachlorophenylalanine, a specific serotonin depletor.


Thermographic, hormonal and clinical studies in migraine.


Light and electron microscope observations on auto- and heterophagy in the exocrine pancreas of the hibernating frog (Rana esculenta).


The Mussolini diary forgeries.

The Mussolini diary forgeries.


An appraisal of therapeutic dentifrices.


Solitary and selected multiple metastases. Diagnosis and management.


Anna O--a study of her later life.

Anna O--a study of her later life.


Heinz Hartmann. 1894-1970.

Heinz Hartmann. 1894-1970.


Herman Nunberg. 1884-1970.

Herman Nunberg. 1884-1970.


Treatment of facial pain with G 32 883 (Tegretol Geigy).


Some observations on the practice of social and preventive medicine in ancient India.


Immunology of tumours.

Immunology of tumours.


Medical history of the pericardium. The hairy hearts of hoary heroes.


The application of fiberoptic indicator-dilution technique to the assessment of myocardial function. II. The interaction of the ejection fraction and end-diastolic volume during exercise and isoproterenol infusion.


Pulmonary stenosis: cyanosis, interatrial communication and inadequate right ventricular distensibility following pulmonary valvotomy.


Pediatric bronchial blocking.

Pediatric bronchial blocking.


On looking at electrical activity of heart muscle.


Transplantation antigens in xenogeneic keratoplasty. II. Insoluble corneal fractions.


Tolerance and frustration.

Tolerance and frustration.


Corneal cryopreservation. II. Ultrastructural and viability changes.


The lens and vitreous.

The lens and vitreous.


Fallacies in child care. 3. That children are brought up by parents.


Swimming pool hygiene.

Swimming pool hygiene.


Thermal inactivation of Salmonella senftenberg 775W in poultry meat.


An improved antigen for the FTA-ABS test.


A cooperative microbiological evaluation of floor-cleaning procedures in hospital patient rooms.


Effects of botulinum toxin on the distribution of succinate dehydrogenase and phosphorylase in fast and slow skeletal muscles of the mouse. A sublethal quantity of botulinum toxin was injected into the muscles of one leg in mice. The histochemical localization of succinate dehydrogenase (SD) and phosphorylase (P) in soleus and gastrocnemius was studied at intervals of from one week to 15 months after the injection of toxin. In normal mice the fibres of soleus are rich in SD and poor in P, but in the superficial part of gastrocnemius the majority of fibres are rich in P and poor in SD. After the injection of toxin the muscles became paralysed and atrophied for several weeks during which time the fibres of gastrocnemius lost their staining reactivity for P and the fibres of soleus showed a weakening of the SD reaction. With the recovery from the effects of the toxin the muscle fibres increased in size and in P activity. Recovery commenced sooner in soleus than in gastrocnemius and for several weeks soleus fibres showed a stronger reaction for P than normal, but with longer survival the enzyme reactions in soleus became normal. Recovery in gastrocnemius began about six weeks after the injection of toxin. Many muscle fibres in gastrocnemius became much enlarged while others remained atrophied. Many fibres gave a strong histochemical reaction for both enzymes. These abnormalities in gastrocnemius seemed to be permanent.


Properties of somatosensory neurones in the human thalamus.


Controlled trial of hydroxocobalamin and riboflavine in Nigerian ataxic neuropathy. The results are presented of a double-blind therapeutic trial of hydroxocobalamin and riboflavine in Nigerian patients suffering from a degenerative neuropathy. Although no benefit from either vitamin was demonstrated, this may reflect the inadequacy of the dosages used. The results are discussed in relation to the hypothesis that dietary cyanide and cyanogens are responsible, at least in part, for the occurrence of this disease in a malnourished population.


Elicitation of moral obligation and self-sacrificing behavior: an experimental study of volunteering to be a bone marrow donor.


Method for the examination of pharmaceutical liquid products for Salmonella.


The clinician's responsibility.

The clinician's responsibility.


Available drugs and promising agents under investigation.


Basic mechanisms of antifungal chemotherapy.


Pulmonary cryptococcosis: special problems in diagnosis and treatment.


Amphotericin B--specifics of administration.


Calcium regulation in man.

Calcium regulation in man.


Hyperparathyroidism.

Hyperparathyroidism.


Disorders of calcium and bone metabolism in chronic renal failure.


Bone disease in intestinal malabsorption.


A new variant of Sporothrix schenckii.

A new variant of Sporothrix schenckii.


Coproporphyrinuria and heart transplantation: its significance.


Improvement of learning in the aged by modification of autonomic nervous system activity. Partial blockade of beta-adrenergic end-organ response to the autonomic nervous system was effected in a group of older men by administration of propranolol. The result was improved performance in a learning task. The data support the hypothesis that the learning decrement found among older men is not simply a manifestation of structural change in the central nervous system but is, at least in part, associated with the heightened arousal of the autonomic nervous system that accompanies the learning task.


Application of the Soviet suturing apparatus in surgery of the colon and rectum.


Specific chemical modification of proteins.


The eukaryotic chromosome.

The eukaryotic chromosome.


A biochemist's anabasis.

A biochemist's anabasis.


Structure and synthesis of ribosomal RNA.


RNA sequence analysis.

RNA sequence analysis.


The biogenesis of mitochondria.

The biogenesis of mitochondria.


Quaternary structure of proteins.

Quaternary structure of proteins.


Enzymes of nucleic acid metabolism.

Enzymes of nucleic acid metabolism.


Lipid chemistry.

Lipid chemistry.


Photosynthesis.

Photosynthesis.


Bacterial cytochromes. I. Structural aspects.


Mechanism of biotin action.

Mechanism of biotin action.


Neurochemistry: at the crossroads of neurobiology.


Chemical synthesis of peptides and proteins.


Prophylaxis of tinea pedis. Efficacy of tolnaftate powder and its talc-cornstarch base.


The treatment of asthma (Robert Hunter).


The coming search for life on Mars.

The coming search for life on Mars.


Current bibliography on allergy and applied immunology.


Management of woumds of the innominate, subclavian, and axillary blood vessels.


The effect of acute mitral insufficiency on hemodynamics of the left heart.


Sir Thomas Browne and the Religio Medici.


An experimental and clinical evaluation of grafts in the venous system.


Mechanisms of thermal injury in nonsporulating bacteria.


Salvage of digits with cross-finger pedicle grafts.


Studies on Serratia marcescens L-asparaginase.


Initiation of DNA synthesis in eucaryotes: a model in vitro system.


Lactose transport coupled to proton movements in Escherichia coli.


In vitro synthesis of phi-X-174 single-stranded DNA.


Amino acid sequence near the amino terminus of porcine pepsin.


Glutamine synthetase deadenylation: a phosphorolytic reaction yielding ADP as nucleotide product.


N6-(delta 2-isopentenyl) adenosine: a heterologous system for in vitro synthesis in E. coli B transfer RNA.


Initiator-like properties of a methionyl-tRNA from wheat embryos.


Lawrence Mans--Achievement Award recipient.


In vitro inhibition of E. coli RNA polymerase transcription of rat liver chromatin by aflatoxin B.


An attempt to localize 5S RNA cistrons in Escherichia coli.


Effect of nucleotide adjacent to 3'-end of codon triplet on ribosomal binding of aminoacyl-tRNA.


The level of Fmt-tRNA on ribosomes from streptomycin treated cells.


Biochemical applications of continuous culture: energy-conservation mechanisms in Torulopsis utilis.


A computer-aided study on the tissue changes in oral keratoses and lichen planus, and an analysis of case groupings by subjective and objective criteria. In a retrospective survey of 235 cases in which the diagnosis on biopsy was lichen planus, keratosis or leukoplakia, the histological features were re-assessed in as objective a manner as possible. For each case, the tissue changes were recorded under 37 headings, without any attempt at interpretation. The information was then transferred to punched cards, and used for various types of computer-aided analysis. Firstly, the frequency with which each tissue change occurred was assessed for each diagnostic group, and the data presented also show how often each change occurred in those cases that subsequently developed a carcinoma.Re-analysis of the cases on the basis of short lists of tissue changes that were thought to characterize each diagnostic category showed, as expected, that many other factors must have played a part in the original diagnosis.Analysis of the histological findings on an objective basis, using a cluster analysis programme, provided an encouraging degree of separation into the diagnostic groups. When a number of known carcinoma cases were included in the cluster analysis as "markers", a small number of leukoplakia and keratosis cases were placed by the computer into the same cluster as these "markers". Of the original 187 cases originally diagnosed as leukoplakia or keratosis, 4.8% are known to have developed a carcinoma, but of the 11 cases the computer placed in the same cluster as the "marker" cases of carcinoma, 36% have subsequently developed carcinoma. Thus, in the cluster analyses, the computer is tending to "recognize" those cases that later developed carcinoma, and to separate them from the bulk of the cases in which malignant change has not occurred.


A clinical comparison between triacetoxyanthracene and dithranol pastes in the treatment of chronic psoriasis.


Treatment of benign familial pemphigus (Hailey-Hailey) by skin grafting.


Zinc and the skin.

Zinc and the skin.


Drug reactions and interactions.

Drug reactions and interactions.


Theories of depersonalization: a re-appraisal.


Important advances in clinical medicine. Epitomes of progress--dermatology.


Medicare's Part B: 1968 figures on enrollment, expenditures, and utilization. A socio-economic report of the Bureau of Research and Planning, California Medical Association.


The fine structure of nerve.

The fine structure of nerve.


Alvolar hypoventilation and benign increased intra-cranial pressure.


Early Delaware physicians. VII. Matthew Wilson, Delaware physician during the Revolutionary Period, 1776-1787.


Horse liver alcohol dehydrogenase. The primary structure of an N-terminal part of the protein chain of the ethanol-active isoenzyme.


ATP: glutamine synthetase adenylyltransferase from Escherichia coli B. Purification and properties.


Nonsense mutants in the regulator gene araC of the L-arabinose system of Escherichia coli B-r.


Genetic analysis of streptomycin resistance in Escherichia coli.


A simple rapid technique for applying skin grafts.


Diarthrodial joints revisited.

Diarthrodial joints revisited.


The challenge to orthopaedics in the English-speaking world.


Human choroid plexus: a light and electron microscopic study.


Reconstruction of the amputated finger tip with a triangular volar flap. A new surgical procedure.


Occult infections of ventriculoatrial shunts.


Electrical recording with micro- and macroelectrodes from the cerebellum of man.


Quantitative and qualitative effects of L-triiodothyronine in massive obesity.


Bromodeoxyuridine sensitization of the ultraviolet-sensitive Escherichia coli ras- mutant to ultraviolet irradiation.


Another one for the book.

Another one for the book.


Solutions not yet polarized.

Solutions not yet polarized.


New RNA polymerase from Escherichia coli infected with bacteriophage T7.


Evidence for premature termination of transcription of the tryptophan operon in polarity mutants of Escherichia coli.


Chain termination of ribosomal RNA synthesis in vitro.


Selective binding of ribosomes to initiation sites on single-stranded DNA from bacterial viruses.


Translation of a purified DNA-RNA complex.


Mechanism of inhibitory action of histones on DNA template activity in vitro.


Current nursing care of the burned patient. A review.


Old salvelinus fontinalis.

Old salvelinus fontinalis.


A viable organ bank.

A viable organ bank.


A weight-promoting drug.

A weight-promoting drug.


Eugene O'Neill and "the practitioner".

Eugene O'Neill and "the practitioner".


Aminoglutethimide: a "side-effect" turned to therapeutic advantage.


Evaluation of fertility control of periodic abstinence.


Fertility drugs.

Fertility drugs.


Oral contraception.

Oral contraception.


Progestogen therapy in early pregnancy and associated congenital defects.


Botulinal toxin and toxoid as antigens.

Botulinal toxin and toxoid as antigens.


Phospholipid metabolism in patients with cerebrovascular disesse.


Electrocardiographic stress tolerance tests.


Aminobutyrate by-pass system in Escherichia coli.


Secondary structure of ribosomal RNA.

Secondary structure of ribosomal RNA. Infrared spectra were obtained for 16S and for 23S ribosomal RNA's in D(2)O solutions. The percentage of each base in the paired and unpaired regions of the RNA was determined from the spectra. The secondary structures of 16S and 23S ribosomal RNA's (from Escherichia coli) are significantly different from each other and are also different from those of yeast ribosomal RNA, formylmethionyl-transfer RNA, and the anticodon fragment of this transfer RNA.


The successful replacement of minute arteries.


Proteolytic reaction of mammalian spermatozoa on gelatin membranes. The acrosomes of spermatozoa of several mammalian species show proteolytic activity when applied to fixed gelatin membranes. The technique permits continuous observation of the enzymatic reaction of an individual spermatozoon. Release of the enzyme occurs solely in the region of the acrosome, in a manner which is species-specific.


Kidney preservation with pulsatile and non-pulsatile hypothermic serum perfusion. Renal clearances in pigs with autotransplanted 24-hour preserved kidneys.


Organ-specific, antirenal cellular hypersensitivity after kidney transplantation.


Renal transplantation and muramidase activity. Urinary muramidase as indicator of tubular damage in patients with renal transplants.


Robert Ernest Noble.

Robert Ernest Noble.


Joseph Albert Augustin LePrince.

Joseph Albert Augustin LePrince.


The effect of pregnenolone sulfate on uterine contractility.


Surgical treatment for urinary stress incontinence in women. Experience in 300 cases with 10 year follow-up.


The human female reproductive tract: immunohistological localization of gamma A, gamma G, gamma M, secretory "piece," and lactoferrin.


Editorial. Orthodontic decades in retrospect and in prospect.


Orthodontists installed as CDS president and president-elect at Canadian meeting.


Stress urinary incontinence--1970.

Stress urinary incontinence--1970.


Massive bleeding due to acute hemorrhagic gastritis.


Fibrinolytic activity following experimental procedures on the liver.


A double-blind comparison of the acridane derivative, clomacran phosphate and trifluoperazine in schizophrenia.


The development of neurological surgery in the United States.


Haldol in the treatment of children with tics and stutterers and an incidental finding.


Hydroxyzine in the treatment of alcoholic withdrawal syndrome.


Dose-response studies of gastric pepsin secretion in man after stimulation with pentagastrin.


Micro-analysis of pure deoxyribonucleic acid-dependent ribonucleic acid polymerase from Escherichia coli. VI. Determination of the amino acid composition.


The intravital method of examining the bone marrow.


Autogenous cancellous bone and marrow transplants.


Neurosurgical procedures for the management of intractable pain.


Pathology of metastatic tumors in bone.

Pathology of metastatic tumors in bone.


Antigenic structure and virulence of Salmonella typhi.


Variable reactivity of antinuclear immunoglobulins with cell nuclei of various origin and quality.


Contribution to methods of studying experimental air-borne infections.


Incidence of the retrocuspid papilla.

Incidence of the retrocuspid papilla.


Tissue reactions to Dycal.

Tissue reactions to Dycal.


Aberrant second premolars.

Aberrant second premolars.


Hand, foot, and mouth disease.

Hand, foot, and mouth disease.


Instant dental utopia?

Instant dental utopia?


The Chediak-Higashi syndrome: case report.


Malnutrition and metabolic rates.

Malnutrition and metabolic rates.


Anemia in children living in the tropics.


Jet injection: high speed infiltration anesthesia.


Plasma levels of apoceruloplasmin and holoceruloplasmin in copper-deficient and normocupremic rats.


Hypothalamic lesions in rats.

Hypothalamic lesions in rats.


A possible mechanism for methionine toxicity in guinea pigs.


Methylmalonyl coenzyme A and fatty acid synthesis by rat liver enzymes in vitro.


Isolation of influenza viruses types A and B in ferret kidney cell culture.


The mechanism of ethionine toxicity to Escherichia coli.


A method for the isolation of intima-media samples from arteries.


Antigen binding and the immune response. II. The large number of antigen-binding cells in primed animals.


Bone marrow restoration of transplantation immunity in the leopard frog Rana pipiens.


Differentiation of group A arboviruses chikungunya, mayaro, and semliki forest by the fluorescent antibody technique.


Lipase in canine gastric juice.

Lipase in canine gastric juice.


Psychological problems and precipitating factors in the stuttering of children.


Biogenic amine uptake by blood platelets and RBC in childhood scizophrenia.


Isolation of Vibrio parahaemolyticus from the processed meat of Chesapeake Bay blue crabs. A method for the recovery of Vibrio parahaemolyticus from seafoods is described. By this procedure, a total of 56 biochemically positive cultures of V. parahaemolyticus were recovered from market samples of Chesapeake Bay processed blue crab (cooked, picked, packed, and refrigerated meat). All of the isolates were tested serologically, and 22 strains were serotyped according to the schema of Sakazaki as follows: K3, K5, K28, K31, K36, K37, K39, K43, and K44. These results indicate the broad distribution of these specific serotypes in a seafood harvested from the Chesapeake Bay.


Occurrence of Vibrio parahaemolyticus and related hemolytic vibrios in marine environments of Washington State. Samples of sediment, water, and fauna were tested for the presence of Vibrio parahaemolyticus and the related biotype V. alginolyticus. Altogether, 379 samples were analyzed quantitatively by using a starch-agar medium. Invertebrate and sediment samples were invariably positive for V. parahaemolyticus, whereas water samples were quite variable. Samples of the Pacific oyster (Crassostrea gigas), obtained on a regular basis for 26 months from a single environment, showed a close correlation between total numbers of mesophilic vibrios and the overlying water temperature; the seasonal counts of oysters ranged from less than 10 to greater than 100,000 per g. Ecological implications and possible pathogenicity of these vibrios are discussed.


Distribution of coliphages in Hong Kong sewage. Coliphage content of sewage collected from 11 different localities in Hong Kong was determined. The number of plaque-forming units (PFU) ranged from 0.036 x 10(3) to 15.9 x 10(3) per ml. In general, urban sewage tended to be richer than rural sewage both in PFU count as well as plaque morphological variation. Seventy-seven isolates were subjected to a host range study. Fifty per cent of these were able to grow on Escherichia coli K-12 as well as E. coli B. Approximately 32% were found to be male specific, and the remaining 18% were K-12 specific although sex-indifferent.