Repair of ectropion using the Bick procedure.


Modification of buried horizontal suture for entropion.


Histologically controlled excision of eyelid tumors.


Attachment of instruments to fingers.

Attachment of instruments to fingers.


Growth of treponema pallidum in rabbits.


Diminished renal urate secretion per nephron as a basis for primary gout.


Hypermagnesemia after renal homotransplantation.


Progressive pulmonary vascular obstruction and cor pulmonale due to repeated embolism from axillary vein thrombosis.


Polymicrobial bacteremia.

Polymicrobial bacteremia.


College mental health and social change.


The marijuana problem.

The marijuana problem.


The literature of ethical problems in medicine-part 1.


Bactericidal activity of a broad-spectrum illumination source. Several hours of exposure to Vita-Lite lamps, which have a unique spectral distribution, give significant killing of cells of Staphylococcus aureus.


Inhibitory effects of ethidium bromide on the growth kinetics of Klebsiella aerogenes, adaptation to ethidium and cross-resistance to proflavine.


Concentrated cultures of Leuconostoc citrovorum. Two single-strain cultures of Leuconostoc citrovorum were grown in a broth medium with automatic pH control. Culture concentrates were prepared by centrifugally harvesting the cells and resuspending them in 1/50th the original volume in 10% nonfat milk solids. The concentrates were stored in liquid nitrogen until analyzed. The maximum population attainable was approximately equal when cultures were grown at pH 6.0, 6.5, or 7.0 with sodium hydroxide or ammonium hydroxide as the neutralizer. Citrate was required in the growth medium for the cultures to be able to produce diacetyl subsequently in milk. At pH 6.0, the cells reached maximum population and ability to produce diacetyl. Organoleptic analysis by an experienced flavor panel showed a preference for cottage cheese creamed with a creaming mixture prepared with a culture concentrate rather than a normal culture. The culture concentrates maintained their viability and ability to produce diacetyl for at least 30 days when stored in liquid nitrogen.


Preparation of agglutinating antisera and fluorescent-antibody conjugates against Pasteurella tularensis in equines. The serological response in burros and horses to the viable LVS strain of Pasteurella tularensis was studied. High-titered agglutinating antisera and fluorescent-antibody conjugates were obtained in both groups of animals. Maximum titers were obtained in horses 14 to 21 days after the start of vaccination and in burros 21 to 28 days after the start of vaccination. The use of Woodhour's adjuvants or booster inoculations did not result in increased titers.


Automated fluorescent treponemal antibody test: instrument and evaluation. Two evaluations of the automated fluorescent treponemal antibody (AFTA) test for the serodiagnosis of syphilis are described. The results of AFTA and manually performed fluorescent treponemal antibody-absorption (FTA-ABS) tests were compared on serum samples from clinically defined donor groups, and the reproducibility of each procedure was studied. Significant improvement of AFTA test results was obtained in the most recent study after developmental modifications of the instrument and test technique. AFTA test agreement with both syphilis and nonsyphilis categories was considered good. With the increasing usage of the FTA-ABS test as an effective tool for the diagnosis of syphilis, successful automation of this procedure is particularly timely and significant.


Use of a titrimetric method to assess the bacterial spoilage of fresh beef. A new method of determining bacterial spoilage in fresh beef is presented. The technique is based upon the fact that as beef undergoes refrigerator spoilage, there is a gradual increase in the production of alkaline substances by the spoilage flora. The level of these substances was measured by titrating meat homogenates to a pH 5.00 end point, employing 0.02 n HCl and an autotitrator. When 23 samples of ground beef from retail stores were tested, an average of 1.32 ml of acid was required for titration of 1 g of fresh beef to pH 5.00, whereas 2.58 ml was required for the same meat at the onset of spoilage. Preliminary data indicate that beef which requires more than 2 ml of 0.02 n HCl/g to lower its pH to 5.00 under the conditions of the test is in some state of incipient spoilage. The statistical correlation between titration values, log bacterial numbers, and extract-release volume was high (P < 0.001). The technique is simple to execute and is highly reproducible, and duplicate samples can be run within 15 min.


Relationship between staphylococcal antiserum titer and zone development on immune serum plates. A workable relationship was established between the standard serum titers of staphylococcal immune antisera and the development of precipitin zones on serum agar around colonies of staphylococcal strains producing homologous antigens (enterotoxins). The standard titer of a serum is defined as the reciprocal of that serum dilution which, with 10 mug of pure enterotoxin per ml, will give a precipitin zone 10 mm in length in single gel-diffusion tubes after 7 days of incubation at 25 C. A numerical scale was set up for determining the intensity of precipitin zones on serum agar. A reading of 3 was considered optimum. This correlated well with a standard serum titer of 25, when 1 ml of such a serum was used per 20 ml of medium per serum plate. From this relationship, the minimum volume of serum required to give optimum precipitin zone development can be calculated.


Survival and activity of frozen starter cultures for cheese manufacture. A study has been conducted on the effect of freezing and storage in liquid nitrogen on 13 strains of lactic streptococci. Cultures were frozen in droplet form and collected in mesh bags. After rapid thawing, the activity of the frozen cultures was compared with a culture of the same organism of the age usually used in cheese-making. The activities of the test and control cultures were traced simultaneously by continuous recording of the pH changes in inoculated milks. Viable counts were performed before and after freezing in liquid nitrogen and after storage in liquid nitrogen. There was no decrease in viable count or loss in activity of the cultures due to freezing and storage. Frozen cultures of some strains showed a shorter lag period after inoculation of milk than control cultures. Frozen concentrated cheese-starter cultures behaved normally in the manufacture of Cheddar cheese.


Identification of staphylococci isolated from clinical material. A total of 350 staphylococci isolated from various clinical sources were examined for bound and free coagulase, fermentation of mannitol, and deoxyribonuclease. The economical coagulase-mannitol-agar method of Esber and Faulcomer was found to be suitable for the detection of free coagulase and mannitol fermentation. A significant number of coagulase- and mannitol-negative staphylococci proved to be deoxyribonuclease-positive.


Rapid fluorescent-antibody stain technique with group A streptococci. A rapid fluorescent-antibody stain technique used with young broth cultures of trypsinized group A streptococci is described. Results from 1,214 trypsinized cultures of group A streptococci employing the rapid stain method were equivalent, both in specificity and sensitivity, when compared to results obtained from identical non-trypsinized cultures stained with the longer standard technique of Cherry, Goldman, and Carski. Moreover, the rapid method requires less than 2 min to complete.


Occurrence of purple sulfur bacteria in a sewage treatment lagoon. The ecology of purple sulfur bacteria in a sewage oxidation lagoon was investigated. Chemical changes in the lagoon were investigated by monitoring biochemical oxygen demand (BOD(5)), sulfide, sulfate, phosphate, total carbohydrates, volatile acids, alkalinity, and pH. Lagoon water temperatures were observed daily. Microbial ecological relationships were deduced by enumerating coliforms, total bacteria other than anaerobes [Tryptone Glucose Extract (TGE) agar], methane formers such as Methanobacterium formicicum, sulfate reducers, purple sulfur bacteria, and algae. Finally, two strains of purple sulfur bacteria were characterized. Two populations, purple sulfur bacteria and total bacteria (TGE agar), reached maximal concentrations in the warmest part of the 1967 summer. Purple sulfur bacteria reached maximal numbers as concentrations of sulfide and volatile acids were depleted, whereas carbohydrates and alkalinity remained unchanged. Low sulfate levels, which were not limiting for sulfate reducers, may be attributable to storage of sulfur within purple sulfur bacteria. No biological, chemical, or physical agent was linked to the removal of coliforms. The increase of algae in the late summer of 1967 may have been related to the low organic content of the lagoon during this period. Although lagoon pH (7.7 to 8.2) was favorable for purple sulfur bacterial growth, temperatures and sulfides were not optimal in the lagoon for these organisms. Chromatium vinosum and Thiocapsa floridana (the predominant lagoon purple sulfur organism in 1967 and 1968) utilized certain carbohydrates, amino acids, volatile acids, and Krebs cycle intermediates. Also purple sulfur bacteria lowered BOD levels as demonstrated by the growth of T. floridana in sterilized sewage.


FTA-ABS test in pregnancy. A probable false-positive reaction.


Hydroxyurea and Escherichia coli nucleoside diphosphate reductase.


Studies on the role of polymorphonuclear leukocytes in neoplastic disease with the chick embryo and Walker carcinosarcoma 256 in vivo and in vitro.


Further observations concerning effects of antilymphocyte serum on tumor growth: with special reference to allogeneic inhibition.


Specificity in the binding of Escherichia coli ribosomes to natural messenger RNA.


Presence of one polypeptide chain in valyl and isoleucyl tRNA synthetases from Escherichia coli.


Substrate specificity of ribosomal peptidyl transferase. The effect of the nature of the amino acid side chain on the acceptor activity of 2'(3')-O-aminoacyladenosines.


Rifampicin resistance of RNA polymerase in the binary complex with DNA.


Methionine synthetase. Existence and interconversion of two enzyme species.


P. Earle Williams, Vice President 1969-70.


Horse liver alcohol dehydrogenase. The primary structure of the protein chain of the ethanol-active isoenzyme.


Editorial. The first fifty years.

Editorial. The first fifty years.


The American College of Dentists: its origin and structure.


Fifty years of public life and professional relationships and still looking ahead.


The American College of Dentists: a critique.


Dental journalism and the American College of Dentists.


D-serine dehydratase from Escherichia coli. II. Analytical studies and subunit structure.


D-serine dehydratase from Escherichia coli. 3. Resolution of pyridoxal 5'-phosphate and coenzyme specificity.


Purification and properties of an aminopeptidase from Escherichia coli.


Accurate thiokol impressions for crown and bridge prosthodontics.


Conversion of non-immune rabbit spleen cells by ribonucleic acid of lymphoid cells from an immunized rabbit to produce IgG antibody of foreign light chain allotype.


The effect of prior transfusion on marrow grafts between histocompatible canine siblings.


The hospital dental services in Great Britain.


Staircase rise in the antibody-forming cell population in secondary response.


Recovery of space loss associated with fractured anterior teeth.


Detection of immune response against synthetic polymers of amino acids employing the plaque-forming cell system. 3. Cross-reaction patterns of antibody secreted in vitro against immunochemically related synthetic polypepides.


Aplastic anemia: a case report.

Aplastic anemia: a case report.


Detection of immune response against synthetic polymers of amino acids employing the plaque-forming cell system. IV. Effect of incorporation of soluble polypeptides into the plaque assay medium.


Differentiation of rosette-forming cells from myeloid stem cells.


An in vitro correlative assay for the immunosuppressive activity of horse anti-rat lymphocyte sera: estimation of lymphocytophilic antibody activity using 51Cr-labeled thymocytes.


Studies on the cytotoxic immune reaction. I. The action of antibodies on normal and regenerating corneal tissues.


Neonatal maxillary molar in conjunction with a congenital scalp defect.


Implications of early anterior crossbite correction.


Appendix and gamma-M antibody formation. IV. Synergism of appendix and bone marrow cells in early antibody response to sheep erythrocytes.


Tryptophan tRNA of Escherichia coli.

Tryptophan tRNA of Escherichia coli.


Failure of long-established skin homografts on ALS-treated mice to induce transplantation tolerance.


Penicillinase distribution in Escherichia coli cells.


Differential rejection of neurones and neuroglia in canine cardiac allografts.


Localization of legumin and vicilin in bean cotyledon cells using fluorescent antibodies.


Mikhail Mikhailovich Shemyakin.

Mikhail Mikhailovich Shemyakin.


The biology of myopia.

The biology of myopia.


[Seroconversions in rubella-vaccine trials].


Warfarin therapy. 2.

Warfarin therapy. 2.


Recurrent aphthous stomatitis and Behcet's disease. A review.


The globulomaxillary cyst: an embryologic misconception.


The endodontic culture technique: a critical evaluation.


Evaluation of the success of endodontically treated teeth.


Near-U.V. photolysis of pyrimidine heteroadducts in E. coli DNA.


A sequential repair model of photoreactivation in bacteria.


Action of photoreactivating light on pyrimidine heteroadduct in bacteria.


Current literature survey of photosynthesis--XXI.


Differential effects of chlordiazepoxide and fluphenazine in two anxious patient populations.


Evaluation of trifluperidol in chronic schizaphrenia.


Widening of the mediastinum resulting from fat accumulation.


The aortic "nipple". The left superior intercostal vein.


Spina bifida: learning problems.

Spina bifida: learning problems.


Rainbow's end: the quest for an optimal taxonomy.


There have been some changes made. Presidential address.


Harold G. Watson, 1903-1967.

Harold G. Watson, 1903-1967.


A brief look into our past history.

A brief look into our past history.


Early use of xenografts as a biologic dressing in burn trauma.


Microsurgery of the common bile duct. An experimental and clinical study.


Studies on the nitrate reductase activity of mycobacteria in the presence of fatty acids and related compounds.


Appropriate name for tap water scotochromogens.


David A. Cooper--in memoriam.

David A. Cooper--in memoriam.


Electron microscope studies of turkey sinus epithelial cells infected with Mycoplasma gallisepticum.


Conference on glomerulonephritis.

Conference on glomerulonephritis.


Conference on glomerulonephritis. Panel discussion, afternoon session.


Evidence for immunologic mechanisms in several forms of human glomerular diseases.


An anthropological essay by Thomas Hodgkin.


Problems of anti-typhoid immunity and protective vaccination against typhoid.


Fungal toxins running rife?

Fungal toxins running rife?


Microsomes, metabolism and toxicity.

Microsomes, metabolism and toxicity.


Dusty problems.

Dusty problems.


The perils of keeping clean.

The perils of keeping clean.


The short pentagastrin test in the investigation of gastric disease.


Why use gastric cytology?

Why use gastric cytology?


Homicidal and suicidal wounds of the throat by Alfred S. Taylor. Some medico-legal comments.


Pendred's syndrome. A historical note.

Pendred's syndrome. A historical note.


An investigation into the sedative properties of salicylamide.


The localization of BCG in the guinea-pig thymus with special reference to Hassall's corpuscles.


Studies on the cellular basis of IgM immunological memory. The induction of antibody formation in bone marrow cells by primed spleen cells.


Aaron D. Spielman (1903-1970).

Aaron D. Spielman (1903-1970).


Joseph E. Heller (1970-1969).

Joseph E. Heller (1970-1969).


Problems facing pharmacists under medicare and medicaid.


A note on relative efficiency in clinical trials.


The simultaneous oral administration of Salmonella dublin, S. typhimurium and S. choleraesuis to calves and other animals.


Disseminated candidosis following aortic valve homograft replacement and tracheostomy.


Maintenance therapy of chronic psychostic patients with a weekly oral dose of R 16 341. A controlled  double-blind study.


A clinical study of the effect of phenobarbital on diphenylhydantoin plasma levels.


Arthus John Hibbert Tomlinson. 31 August 1916--17 November 1967.


Enzymic synthesis of DNA. 33. Hydrolysis of a 5'-triphosphate-terminated polynucleotide in the active center of DNA polymerase.


Effects of perhexiline maleate on exercise-induced tachycardia.


Study of porosity and voids in dental gold castings.


A controlled trial of benzoctamine (Ba-30803) in neurotic anxiety.


Presidential inaugural address: the next 50 years--new goals.


Studies on the structure of human enamel by the replica method.


Fragments of alkaline phosphatase from nonsense mutants. I. Isolation and characterization of fragments from amber and ochre mutants.


Ernest Browning Forbes. A biographical sketch.


A. L. Woolf, (1918-1970).

A. L. Woolf, (1918-1970).


Amino acid substitutions resulting from suppression of nonsense mutations. IV. Leucine insertion by the Su6+ suppressor gene.


Recalcification of artificially decalcified dentin in vivo.


Liver transplantation in the pig.

Liver transplantation in the pig.


The greasy pole.

The greasy pole.


Sequential changes in response to dental procedures.


Cariogenic streptococci invasion of decalcified teeth.


Degenerative changes in the superficial epithelium of chronic hyperplastic oral mucosa: clinicopathological and histochemical study.


Structure of RNA in ribosomes.

Structure of RNA in ribosomes. The 50S and 30S ribosomes and 23S and 16S RNA were hydrolyzed with ribonuclease A. The rate constants and number of fragments produced were determined for each reaction. The conformation of 23S RNA changes when the RNA is extracted from the ribosome. Specific regions of the RNA in 50S and 30S ribosomes are protected from hydrolysis by the ribosomal proteins.


1970 supplement to the 1969 directory of nurses with earned doctoral degrees.


The metabolism of the placenta.

The metabolism of the placenta.


Intestinal factors in the regulation of insulin secretion.


Antidiuretic hormones synthesis, release, and action under normal and pathological circumstances.


Geriatric nursing. The essence of utilization review--the welfare of the patient.


Efferent projections of the head of the caudate nucleus in the cat.


Stridor, myelomeningocele, and hydrocephalus in a child.


Double-blind controlled trial of a throat spray containing benzocaine and cetalkonium chloride on postoperative adult tonsillectomy patients.


A method of analyzing, surveying for removable partial dentures.


Nineteenth Century wound management of the parturient uterus and compound fracture: the Semmelweis-Lister priority controversy.


Psychophysiologic responses in clinical practice.


Combined therapy in anxiety-depressive syndromes. II. Comparative effects of amitriptyline and limbitrol (chlordiazepoxide-amitriptyline).


Microtechnique for serological diagnosis of brucellosis. Comparison with the agglutination and the surface fixation tests.


Survival gain and volume gain. Mathematical tools in evaluating treatments.


Aging, immunity, and malignancy.

Aging, immunity, and malignancy.


Contact lens history and parameters.

Contact lens history and parameters.


Study on rifampicin. I. Penetration into the bone in man after single dose of 750 mg.


Ethacrynic acid alone and in combination with methyldopa in the management of mild hypertension. A report of 23 patients.


The amytal and the cold pressor tests in relation to the aetiology and to the therapy of arterial hypertension.


The ideological wellsprings of psychoanalysis.


Further reflections on reintegration in specialist medicine. Address to the World Congresses of Neurological Sciences, 1969.


Binding of transfer RNA and arginine to the arginine transfer RNA synthetase of Escherichia coli.


Congenital defects of the scalp. A surgical approach to aplasia cutis congenita.


State approved schools of nursing--R.N. meeting minimum requirements set by law and board rules in the various jurisdictions; 1970.


Focus on Dundee. Profile of an administrator (Evelyn Ireland).


Koch's comma.

Koch's comma.


Anticoagulants and coronary heart disease.


Coronary care units.

Coronary care units.


Structure and function of E. coli formylmethionyl tRNA. I. Effect of modification of pyrimidine residues on aminoacyl synthetase recognition. E. coli formylmethionyl tRNA (tRNA(fMet)) has been irradiated with ultraviolet light in the presence of Mg(2+) to the extent of 50 per cent inactivation of amino acid acceptance. Separation of active and inactive molecules after irradiation has shown that ultraviolet light modification of the uridine in the anticodon, the uridine in the small loop, the 4-thiouridine, and the pyrimidines in the double-stranded stem adjacent to the dihydrouridine loop has no effect on aminoacylation or transformylation. The ultraviolet light-induced inactivation of methionine acceptance by tRNA(fMet) is due almost entirely to modification of the cytidine residues in the 3'-terminal CCA-OH sequence.


The English sweating sickness.

The English sweating sickness.


Termination of pregnancy by intra-amniotic hypertonic solutions.


Defects of the auditory ossicles in ears with intact tympanic membrane. Clinical studies.


Metabolism of L(plus)-lactate in human skeletal muscle during exercise.


Pathophysiology of peptic ulcer.

Pathophysiology of peptic ulcer.


Operative treatment of the advanced stasis ulcer using muscle transposition. A follow-up study.


Release of an axillary burn contracture of thirty years' duration.


Detection and incidence of Escherichia coli on storage pen surfaces of fishing trawlers. Six methods for the detection and enumeration of Escherichia coli on the storage pen surfaces of commercial fishing trawlers and in harbor wash water were evaluated. E. coli was found consistently present in Boston harbor water used for washing vessel holds and was detected either in small numbers or not at all on storage pen surfaces. Violet Red Bile Agar as a primary enumeration medium was found ineffective for detection of coliforms because of the nonselective development of large numbers of other gram-negative organisms. The use of E. coli broth at 44.5 C for primary most-probable-number determinations, followed by confirmation of E. coli on Levine Eosine Methylene Blue Agar, appears to offer numerous advantages over more conventional methods of detecting E. coli for survey studies of the fishing industry, where coliform-like organisms result in many false-positive presumptives with other methods.


Optimum skin blending method for quantifying poultry carcass bacteria. Optimum blending fluids and blending times for use in quantifying bacteria on poultry carcass skin by the skin "blending" method were determined. Butterfield's buffered-phosphate diluent, physiological saline solution (0.85% NaCl), peptone water (0.1% peptone), and deionized water, each at four different skin blending times of 1, 2, 3, and 4 min, were compared. The comparison was based on relative numbers of bacteria per cm(2) of skin, enumerated by each combination on turkey carcasses. Peptone water and physiological saline solution each yielded significantly (P < 0.01) higher bacteria counts from turkey carcass skin samples than did Butterfield's buffered-phosphate diluent or deionized water. There were no significant differences among the four skin blending times and no significant interaction effect between the two factors tested.


Detailed methodology and implementation of a semiautomated serial dilution microtechnique for antimicrobial susceptibility testing. The detailed methodology and implementation of a semiautomatic microtechnique for performing serial dilution antimicrobial susceptibility studies are described. Quantitative susceptibility studies to a battery of antimicrobials are performed routinely on all significant clinical isolates. Results are reported as the minimal inhibitory concentration in micrograms per milliliter of broth. Guidelines relating standard doses of antimicrobials with expected blood and urine levels are presented to facilitate the use of the quantitative data. This microtechnique is used to measure serum and other body fluid levels of antimicrobial agents to document the level attained with a specific course of therapy. This technique is highly reproducible and has a high correlation with, and is at least 10 times faster than, standard glass tube techniques.


Medium for differential count of the anaerobic flora in human feces. On reinforced clostridial agar with blood and 0.03% China blue, organisms of the bacteroides group grow with blue translucent colonies, whereas bifidobacteria grow with opaque brown colonies. This permits the differential counting of the predominant anaerobic organisms in human feces on one medium.


Deoxyribonuclease-positive Staphylococcus epidermidis strains. Use of the agar plate test for the enzyme deoxyribonucleate 3'-nucleotidohydrolase (deoxyribonuclease) can result in frequent misdiagnosis of Staphylococcus epidermidis as S. aureus.


Preservation of Mycoplasma strains by freezing in liquid nitrogen and by lyophilization with sucrose. Procedures for maintaining Mycoplasma strains are described. Liquid nitrogen storage provided an adequate means for keeping stock cultures stable. Over 74 strains of approximately 26 species have been preserved in this way, some for as long as 9 years. Mycoplasma strains can also be recovered satisfactorily from the freeze-dried state when the procedure described includes the use of 12% (v/v) sucrose as an additive. Fifteen strains representing 12 or more species were subjected to a freeze-drying program with and without sucrose added to concentrated cell suspensions in growth medium. Cell counts indicate improved survival with sucrose.


CELO virus: an oncogenic virus. Brief report.


Binding of cytidine triphosphate to aspartate transcarbamylase.


The transport of beta-galactosides across the membrane of permeaseless Escherichia coli ML35 cells after treatment with cetyltrimethylammonium bromide.


Cation repair of toluene-treated Escherichia coli ML35 cells and the transport of O-nitrophenyl-D-beta-pyranoside-galactoside across the repaired membrane.


The effect of Apurin (allopurinol) on liver function and serum iron.


Transitional lower denture: how to convert a patient to a full lower denture utilizing the remaining healthy dentition.


Food irradiation: a complex conundrum.

Food irradiation: a complex conundrum.


Pesticides turning the corner?

Pesticides turning the corner?


The gospel of gastroscopy in the United States.


Gonadotropin-releasing activity in the quail hypothalamus.


Failure of dopamine to promote spermiation in toads.


Alloxan effects on blood glucose level and pancreatic islet tissue in Lampetra fluviatilis.


Steroid formation by the avian ovary in vitro (Gallus domesticus).


Fifty-one years in the art: a family physician remembers.


Carl A. Moyer, M.D., a humanistic devotee of the scientific method.


The early diagnosis of pancreatic cancer.


Simultaneous determination of the apparent 3HOH, 82Br, 125I human albumin and 51Cr red cell volumes in human subjects.


Gastric ulcer.

Gastric ulcer.


The pathophysiological role of small intestinal bacterial flora.


Crohn's disease (regional enteritis). A look at the last four years.


Causes and effects of acute liver damage.


Current concepts in cirrhosis.

Current concepts in cirrhosis.


Gastric stasis, a cause of gastric ulcer.


Aetiology and pathogenesis of pancreatitis. (Current concepts).


Ulcerative colitis 1970--recent developments.


Recent advances in tropical malabsorption.


The clinical use of gastric function tests.


The indirect fluorescent antibody technique as a method for detecting serum antibodies against hog cholera. I. An outline of the technique and its preliminary evaluation.


Experimental salmonella infections in pigs.


Recent progress on systemic contraceptives.


The identification and topographical localisation of the olfactory epithelium in man and other mammals.


Presentation of the Gold Headed Cane to Alan R. Moritz, March 10, 1970.


"Mother, father, and daughter": a three-aspect ambiguous figure.


Malathion poisoning. A fatal case with cardiac manifestations.


Tests to assess effects of low levels of air pollutants on human health.


Human thresholds of electric shock at power transmission frequencies.


Dr. Sam. 8. Time out. (Samuel Booth Sturgis).


The production of jet as an occupation.

The production of jet as an occupation.


Bacteriuria in the first month following renal transplantation.


Electron microscopic identification of monoamine nerve ending particles in rat brain homogenates.


Lysine as substrate for ornithine carbamoyltransferase.


The effect of l-asparaginase on blastic transformation and DNA synthesis in human lymphocytes.


On the enzyme hydrolysis of fraction Cbeta, isolated from total zein by means of gel filtration.


Group therapy and the small-group field: an encounter.


The group psychotherapy literature 1969.


Serum proteins, amyloid and Alzheimer's disease.


Management of infections and infestations in the elderly.


Determination of the decomposition of aspirin.


Irreversible brain damage and related problems: pronouncement of death.


Policemen and the recall of criminal details.


In memoriam. Saul Bien, D.D.S. (1913-1969).


Studies on figure drawings: biological implications of structural and graphic characteristics.


Psychological characteristics of adopted children.


Existential psychology and a romantic poem.


Influence of a benign virus upon mouse leukemia during asparaginase therapy.


Smoking and health.

Smoking and health.


The importance of research in biogenic amines for the experimental psychopharmacology.


Neurophysiological and biochemical aspects in the action of antidepressant drugs.


Psychotropic properties of the cholinesterase reactivator TMB-4 in healthy man.


Effects of octoclothepin and chlorpromazine evaluated by a standardized interview.


Dixyrazine in the treatment of neurosis.


Long acting peroral fluphenazine and its dosage in psychoses.


The effects of chlorpromazine on some components of psychomotor performance in schizophrenics.


Tetanus prophylaxis: laboratory aspects.


A study of aortic regurgitation in aortic-valve homografts.


Posttraumatic coronary arteriovenous fistulas with surgical cure.


Surgical management of secondary tracheomalacia.


Congenital absence or deficiency of lung tissue. The congenital subtractive bronchopneumonic malformations.


Angiopathy of retinal vessels in diabetic mice.


Experimental uveitis. I. The production of recurrent immunologic (Auer) uveitis and its relationship to increased uveal vascular permeability.


Experimental uveitis. II. The pathogenesis of recurrent immunologic (Auer) uveitis.


The uvea.

The uvea.


Ocular vascular permeability. Effect of systemic administration of bacterial endotoxin.


5-hydroxyindoles in hydrocephalus. A comparative study of cerebrospinal fluid and blood levels.


Effects of testosterone on body image and behavior in Klinefelter's syndrome: a pilot study.


Old and new Philadelphia plans for mental health.


A quantitative study of the Purkinje cells in the cerebellum of the albino rat.


Axial ventriculography.

Axial ventriculography.


Dark adaptation and night vision.

Dark adaptation and night vision.


Drugs, diagnoses, and outcome of drug trials with neurotic patients.


Some glimpses of comparative avian physiology.


Damage assay of kidneys frozen by intraarterial perfusion with a fluorocarbon.


Preservation of excised canine lungs by ventilation with liquid fluorocarbon.


Bone cell differentiation in avian species: with comments on multinucleation and morphogenesis.


Peripheral control of avian respiration.


Chronic osteomyelitis. I. Factors affecting the results of treatment in 186 patients.


An open community trial of live rubella vaccines. Study of vaccine virus transmissibility and antigenic efficacy of three HPV-77 derivatives.


Chronic osteomelitis. II. Treatment with closed irrigation and suction.


Sigmund Freud (1856-1939). Founder of psychoanalysis.


Investigational exemption procedures for new drugs.


Adult lactose tolerance.

Adult lactose tolerance.


Julius Wolff (1836-1902). Morphogenesis of bone.


The effect of endogenous pyrogen on the plasma zinc concentration of the rat.


The effect of bretylium tosylate on the pulmonary arterial and venous circulations of the intact anesthetized dog.


Unique cleavage planes in frozen red cell membranes.


Cytokinetics of IGG vs IGM PFU response in the lungs of C3H mice.


Freud's theory of conflicts.

Freud's theory of conflicts.


Amour and eros in the Middle Ages.

Amour and eros in the Middle Ages.


A psychoanalytic reading of "Troilus and Cressida" and "Measure for Measure".


Freu, Leonardo and The Lamb.

Freu, Leonardo and The Lamb.


Dostoevsky and "The Gambler": a contribution to the psychogenesis of gambling. II.


Myth and archetype in "Julius Caesar".

Myth and archetype in "Julius Caesar".


The management of malignant tumors of the testes.


Rapid estimation of areas under thermodilution curves.


Muscle antibodies in myasthenia gravis.

Muscle antibodies in myasthenia gravis.


Aspects of the pathology of presenile dementia.


Treatment of Parkinsonism with L-dopa.

Treatment of Parkinsonism with L-dopa.


L-dopa treatment in Parkinson's disease.


Congenital cystic dilatation of the common bile duct: a review.


Amantadine treatment of Parkinson's disease.


Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture.


On the oncogenic properties of chicken embryo lethal orphan virus, an avian adenovirus.


Homogeneity of differentiated function in mammary carcinoma cell populations.


Kinetics of normal and leukemic leukocyte populations and relevance to chemotherapy.


Leukocytes and sperm capacitation in the rabbit uterus.


The renal medulla as an antihypertensive organ.


The cellular reactions to heterologous, homologous and autologous skin implanted into brain.


Transoral bone graft for atrophy of the mandible.


A quantitative study of a spina bifida foetus.


Hypothalamic temperature and the regulation of respiration of the ox exposed to severe heat. 1. Thermodes have been chronically implanted in the hypothalamus of the ox.2. During exposure of the ox to severe heat stress, rapid shallow panting changed to slower deeper panting when hypothalamic temperature (T(hy)) was approximately 40.5 degrees C. With subsequent rapid ambient cooling, hypothalamic temperature declined rapidly, and there was a reversion to rapid shallow panting before respiration slowly returned to normal.3. When hypothalamic temperature and rectal temperature (T(R)) had reached about 40 degrees C, raising hypothalamic temperature to about 41.4 degrees C did not cause the onset of slower deeper panting.4. When hypothalamic temperature and rectal temperature had exceeded about 41 degrees C and slower deeper panting was well established, lowering hypothalamic temperature to about 40 degrees C did not cause any reversion to rapid shallow panting.5. When hypothalamic temperature and rectal temperature had reached about 40 degrees C, holding hypothalamic temperature at 40 degrees C did not prevent the onset of the slower deeper phase of panting.6. Under moderate heat stress when hypothalamic temperature was approximately 39.9 degrees C and rectal temperature was approximately 40.4 degrees C, raising hypothalamic temperature at the same rate as that which was associated with the onset of slower deeper panting during severe heat stress, resulted in a parallel increase in the respiratory frequency and fall in rectal temperature; there was no change to the slower deeper form of panting.7. Holding hypothalamic temperature at 41.7-42 degrees C during post-heat cooling did not prevent the reversion to rapid shallow panting.8. It was concluded that the change from rapid shallow to slower deeper panting during severe heat stress, and the reversion to rapid shallow panting during subsequent cooling, were not the result of changes in temperature of the hypothalamic thermoregulatory centres.


Demonstration of immune complexes by mixed immunofluorescence in synovial membrane of patients with rheumatoid arthritis.


Potentiation of a monoamine oxidase inhibitor by tryptophan.


An introduction to some of the problems of intersexuality.


The problem of the bovine freemartin.

The problem of the bovine freemartin.


Drug-induced intersexuality in mammals.

Drug-induced intersexuality in mammals.


Infertility in women clinically attributed to uterine factors.


The utero-ovarian relationship and its possible role in infertility.


Infertility in domesticated animals clinically attributed to uterine factors.


Body water in human pregnancy.

Body water in human pregnancy.


The fetal fluids of domestic animals.

The fetal fluids of domestic animals.


Automatic diagnosis of congenital heart diseases by electronic computer.


Appearance of nephritis associated with type 57 streptococcal impetigo in North America.


Overuse of IPPB.

Overuse of IPPB.


A controlled trial of cyclophosphamide in rheumatoid arthritis.


Artificial cardiac pacemakers. I.

Artificial cardiac pacemakers. I.


Assessment of drug efficacy in rheumatoid arthritis.


Immunosuppression and malignant neoplasms.


The prospect of organ transplantation in cancer surgery.


Ambulatory arterial infusion in the treatment of primary and secondary skin cancer.


Morphological criteria in the classification of the malignant lymphomas.


Indications and principles of amputation for bone sarcoma.


Present status of studies on the virus etiology of cancer.


Odontodysplasia leprosa in Danish mediaeval skeletons.


Study of late ocular syphilis. Demonstration of treponemes in aqueous humour and cerebrospinal fluid. I. Methods of demonstration of treponemes.


Study of late ocular syphilis. Demonstration of treponemes in aqueous humour and cerebrospinal fluid. II. Ocular findings.


Symposium on certain forms of infective kerato-uveitis or uveitis: concluding remarks.


Study of late ocular syphilis. Demonstration of treponemes in aqueous humour and cerebrospinal fluid. 3. General and serological findings.


Cataract section and wound closure.

Cataract section and wound closure.


The surgical management of senile entropion.


Intra-ocular pressure and wound closure after cataract extraction.


Therapeutic keratoplasty in young children.


Peripheral cataract extraction.

Peripheral cataract extraction.


Notes on the development of cryosurgery in ophthalmology.


Studies in urinary tract infections. V. Urinary concentrating ability.


Spirometric measurement of ventilation.

Spirometric measurement of ventilation.


Low incidence of bends following renitrogenation in an altitude training profile.


Dress rehearsal for the hospital.

Dress rehearsal for the hospital.


Experimental resection of myocardial infarction.


Surgery of pterygium. Modified McGavic's technique.


The use of ETOX lyophilised skin in burns.


The effects of "delay" on the survival of experimental pedicled skin flaps.


The James Ewing lecture. Categorical approach to cancer control: the state of the art.


Nitrosoureas: 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962; BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC-79037; CCNU)--clinical brochure.


Proposed guidelines for protocol studies. Prepared by a Committee of the Chronic Leukemia-Myeloma Task Force, National Cancer Institute.


Azotomycin (NSC-56654)--clinical brochure.


Proposed guidelines for protocol studies. 3. Chronic lymphocytic leukemia. Prepared by a Committee of the Chronic Leukemia--Myeloma Task Force, National Cancer Institute.


Proposed guidelines for protocol studies. IV. New agents in the treatment of chronic granulocytic leukemia. Prepared by a Committee of the Chronic Leukemia--Myeloma Task Force, National Cancer Institute.


Intraluminal small-intestinal utilization of d-xylose by bacteria. A limitation of the d-xylose absorption test.


Effects of antrectomy on the fundic mucosa of the rat.


The esophagus: 1967 to 1969. I.

The esophagus: 1967 to 1969. I.


Immunohistological studies on thyrocalcitonin in C-cells.


Studies on the mode of action of althiomycin.


Inhibition of nucleic acid biosynthesis in cell-free systems of Escherichia coli B by pluramycin.


Proliferation of erythroid-committed cells in the absence of erythropoietin.


Binding of blasticidin S to ribosomes.

Binding of blasticidin S to ribosomes.


Skin blood flow in scleroderma.

Skin blood flow in scleroderma.


Hemolysis in capillary flow.

Hemolysis in capillary flow.


An evaluation of adsorption methods for measurement of plasma iron-binding capacity.


N-aminoalkylpolyglycine. Synthesis, antibacterial activity, and electrochemical behavior as a titrant of living cells.


Gonadotrophin-secreting bronchial carcinoma: aberrant endocrine activity or trophoblastic differentiation?


In-vivo nuclear localisation of human antinuclear antibodies in mice with carbon tetrachloride- and thioacetamide-induced hepatic necrosis.


Transferase from Escherichia coli effecting low-energy phosphate transfer to nucleosides and nucleotides. This communication describes the partial purification of an enzyme in Escherichia coli that is capable of a low-energy transfer of organically bound phosphate to nucleosides, nucleoside 5'-phosphates, and deoxyribonucleoside 5'-triphosphates. With the exception of adenosine, the nucleosides give rise almost exclusively to 2'- and 3'-nucleotides. Thymidine and its derivatives are the best acceptors of phosphate groups. Since 5'-nucleotides are converted in high yields to the nucleoside 3',5'- or 2',5'-diphosphates, the enzyme may be regarded as a nucleotide phosphotransferase. In the ribonucleotide series, the aglycone affects the relative amounts of 2' and 3' derivatives. The noteworthy formation of nucleoside tetraphosphates suggests several regulatory functions of this enzyme which are discussed briefly.


Control of initiation of DNA synthesis in Escherichia coli B-r. The pattern of new growing forks in the Escherichia coli genome after a period of inhibition of DNA synthesis has been examined. Synchronous cultures of E. coli B/r were treated with nalidixic acid to stop DNA synthesis for various lengths of time. After removal of the nalidixic acid the location of active growing forks was determined by measuring the reversion rate of a histidine requirement induced by the "growing-point mutagen," nitrosoguanidine. It was found that the ability to initiate a new round of DNA synthesis upon release from the nalidixic acid block was attained at the cell age at which a new round of replication would have been initiated had DNA synthesis not been blocked. However, if the nalidixic acid was removed before the normal initiation age, the initiation of the next round of synthesis was delayed past the normal time, which indicates that initiation of new rounds is not completely independent of DNA synthesis.


An endonuclease activity from Escherichia coli absent from certain rec- strains. A new endonuclease activity from Escherichia coli which cleaves circular, single-stranded DNA in the presence of added nucleoside triphosphate has been purified. The activity has not been detected in extracts from certain rec(-) strains and is therefore implicated in genetic recombination.


Peptide chain termination with mammalian release factor. We report a method for the in vitro study of peptide chain termination in mammals. A proteinaceous release factor has been isolated from rabbit reticulocyte extracts. This factor and a polyribonucleotide template containing the bases U and A stimulate the release of N-formylmethionine from mammalian [N-formylmethionyl-tRNA(f).ribosome] intermediates. Our studies suggest that UAA is a terminator codon for mammalian cells.


Radiological measurement of skin thickness and bone mineral.


Hormonal control of protein synthesis.

Hormonal control of protein synthesis.


Histochemistry of atherosclerosis.

Histochemistry of atherosclerosis.


Kinin formation in human diseases.

Kinin formation in human diseases.


Elements of the vascular system.

Elements of the vascular system.


Biochemistry and the myelin sheath.

Biochemistry and the myelin sheath.


Metabolic, endocrine and psychiatric aspects of anorexia nervosa.


Virus structure.

Virus structure.


The vectors of antibiotic resistance in bacteria.


The cell-mediated immunological response.


The possible chemotherapy of respiratory virus diseases.


Recent advances in the study of the leprosy bacillus.


The retinal circulation in hypertension and diabetes.


A study of cancer patterns in Africa.

A study of cancer patterns in Africa.


Clinical research in Hodgkin's disease.

Clinical research in Hodgkin's disease.


Function of the liver after isolated cold perfusion.


A simple technique for effective decompression of the small intestine.


Aortocoronary vein bypass graft.

Aortocoronary vein bypass graft.


Changes in the materal cardiovascular system during human pregnancy.


Coping with a chronic disability. Psychosocial observations of girls with scoliosis treated with the Milwaukee brace.


Alteration of LH and FSH release in rats treated with clomiphene or its isomers.


Evaluation of an injectable progestin-estrogen as a contraceptive. A study involving an injectable contraceptive regimen utilizing 2 commercially available hormonal preparations, medroxyprogesterone acetate (Depo-Provera, The Upjohn Company) and estradiol-17 beta-cyclopentylpropionate (Depo-Estradiol  Cypionate, The Upjohn Company), is described.  90 multigravidas received intramuscular injections of 50 mg of medroxyprogesterone acetate and 10 mg of estradiol-17 beta-cyclopentylpropionate as a contraceptive every 5 weeks, for a total of 1155 periods.  The injections were found to be safe and completely effective.  In 15% of the therapeutic cycles, bleeding did not appear for a period of 30 or more days.  In 14%, bleeding and/or spotting lasted for longer than 9 days during a 30 day period.  The incidence of aminorrhea increased somewhat after the first 10 months of treatment.  Endometrial biopsies showed a "suppressed" endometrium.  Adrenal pituitary responsiveness to metyrapone was found to be normal in 17 of 21 patients tested.  Although almost half of the patients presented some complaints during the study, these were mostly transient and minor in nature.  Headache was the complaint most frequently observed (14%), but it was generally limited to 1 cycle.  The monthly injectable contraceptive regimen may be useful in a particular population of patients who, for various reasons, cannot tolerate or cannot be relied upon to take oral contraceptives.  The authors believe that because of the high incidence of alterations in the bleeding pattern while on the therapeutic regimen, as well as the frequent occurrence of aminorrhea following discontinuation of therapy, the use of such a  contraceptive regimen in the general population might not be desirable.


Perphenazine-amitriptyline in neurotic depressed outpatients: a controlled collaborative study.


Placebo-control evaluation of desipramine in depression.


A comparison of lithium carbonate and chlorpromazine in mania.


Clarence B. Farrar 1874-1970.

Clarence B. Farrar 1874-1970.


Androgens and reptilian spermatogenesis.


Surface protrusions from the ependymal cells of the median eminence.


Studies on the nasal gland of birds.

Studies on the nasal gland of birds.


On the evolution of the median eminence--the proximal neurosecretory contact region in some fishes (Elasmobranchii, Chondrosteoidei).


Relation of pineal acetylserotonin methyltransferase activity to daily photoperiod and light intensity.


Role of the eyes and superior cervical ganglia on the effects of light on the pineal and gonads of the Japanese quail.


Seasonal variations of cardiac glycogen and fat bodies weight and their relationship with prolactin in Triturus cristatus.


Relation of thyroid to gonadal and body weight cycles in male weaver bird, Ploceus philippinus.


Neuro-intermedial relation in the hypophysis of frog's larvae.


Kinetic studies of tryptophan synthetase. Interaction of substrates with the B subunit.


Purification and properties of vitamin B6 kinase from Escherichia coli B.


Synthesis and chemical properties of monomers and polymers containing 7-methylguanine and an investigation of their substrate or template properties for bacterial deoxyribonucleic acid or ribonucleic acid polymerases.


Active subunits of the aspartokinase-homoserine dehydrogenase I complex from Escherichia coli.


Double-blind cross-over comparison of aceclidine and pilocarpine in open-angle glaucoma.


The delivery and distribution of coronary collateral circulation.


Reminiscences. George Burch.

Reminiscences. George Burch.


Gaston Chappaz (1899-1967).

Gaston Chappaz (1899-1967).


Meningioma--a case report in bullock.

Meningioma--a case report in bullock.


Granulosa cell tumour in a guinea pig.

Granulosa cell tumour in a guinea pig.


Pulmonary embolism: modern concepts and diagnostic techniques.


John S.--widower.

John S.--widower.


A memorial tribute to Edward L. Bortz, M.D.


Vaccination against Hong Kong influenza in Britain, 1968-9. A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines. Studies of the effect of Hong Kong (HK) influenza vaccine were made in adults and children in Great Britain during 1968 and 1969. The vaccines were administered intramuscularly and also by intranasal spray. The serum antibody response was studied in 284 subjects. Most developed rising titres to vaccine given intramuscularly and few to vaccine given intranasally. Deoxycholate-split vaccine was as potent as conventional whole virus vaccine. Antibody titres were maintained for months. Over 4000 subjects in factories, offices and schools were observed during the epidemic. The incidence of disease was not significantly reduced by either form of vaccination. A survey was made of epidemics in boarding schools in which some of the pupils had been vaccinated, in six with commercial polyvalent vaccine and in five with HK; there was a lower incidence of influenza in two schools vaccinated 2 or 4 weeks earlier with HK vaccine.


A comparison of monovalent Hong Kong influenza virus vaccine with vaccines containing only pre-1968 Asian strains in adult volunteers. A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines. A total of 1601 adult industrial workers were vaccinated with either monovalent inactivated vaccine of the Hong Kong strain of influenza A virus, or with polyvalent vaccine containing only pre-1968 Asian viruses. Serological investigations on a random sample of volunteers showed that 53/56 (95%) given Hong Kong vaccine developed a significant rise in specific haemagglutination-inhibiting antibody; final titres were 1/48 or greater in 39 (70%) and the GMT (geometric mean titre) was 96.5. After polyvalent Asian vaccine, 40/67 (60%) also produced antibody against Hong Kong virus, but only 21 (31%) had final titres of 1/48 or above, and the GMT rose only to 14.1. An intranasal spray of the Hong Kong vaccine in addition to injected Asian vaccine gave no additional increase in antibody.Each type of vaccine stimulated a recall of pre-existing antibody against Asian viruses. The possible significance of heterologous responses to the two vaccines is discussed.The incidence of clinical influenza in the trial population was sporadic, and the infection rates were too low to allow any accurate estimate of the protective efficiency of the two vaccines.


Experimental encephalitis following peripheral inoculation of West Nile virus in mice of different ages. Experimental arbovirus infections of mice provide a convenient model to study factors which determine the occurrence or severity of encephalitis following extraneural infection with certain neurotropic viruses. Varying doses of West Nile or Powassan viruses were inoculated by intraperitoneal or intramuscular routes into mice of varing ages; individual variables were manipulated to influence the outcome of infection. Three patterns of pathogenesis were delineated: (1) Fatal encephalitis, preceded by early viraemia, and invasion of the central nervous system. (2) Inapparent infection, with no detectable viraemia and no evidence of central nervous system invasion. (3) Subclinical encephalitis, usually preceded by trace viraemia, with minimal transient levels of virus in the brain. In this latter type of subclinical infection with a potentially lethal virus, the immune response probably plays an important role in recovery.


Temperate bacteriophages of Escherichia coli O119:B14. Lysogeny was detected in 98.8% of the 343 Escherichia coli O119:B14 strains. A suitable indicator strain E. coli KS was selected to demonstrate the presence of temperate phages in this serotype. A great diversity in the temperate population was observed based on their lytic patterns and neutralization studies. No definite relationship could be established between the biochemical reactions and the flagellar antigens of the lysogenic strain and its temperate phage though some temperate phages released by E. coli O119:B14 strains with certain flagellar antigens did give specific lytic patterns and were serologically identical. Lysogenic strains, which did not release temperate phages spontaneously, were u.v. inductible. Cross-reactions with lysogenized colonies which were immune to corresponding phages also confirmed diversity of temperate phages in E. coli O119:B14.


Body image in dentistry.

Body image in dentistry.


Recoveries of bacteria after drying and heating in glutamate foams. A method of drying bacteria is described, in which the bacterial suspension was made in 40% sodium glutamate, and 0.1 ml. volumes of this in 8 ml. ampoules were dried in vacuo while being held in a water bath at 25 degrees C. After 1 hr. with the pump still running, the ampoules were immersed in water at 100 degrees C. The partly dried suspension expanded rapidly into a homogeneous white foam. After 30 min. the ampoules were taken off the manifold; small tubes containing dry P(2)O(5) were inserted in the ampoules which were then sealed in air. Preliminary results with three organisms, Salmonella ndolo, Staphylococcus aureus and Serratia marcescens showed high survivals immediately after the ;foaming' period, and good stability after 1 or 2 days at 100 degrees C.


Clinical considerations improving obturator treatment.


Laser welding of prostheses--an initial report.


Chemical and biochemical implications of human and animal exposure to toxic substances in food.


Survey of the hazards of the chemical age.


Charcot joints.

Charcot joints.


Effects of drugs on perception in man.

Effects of drugs on perception in man.


Routine pre- and post-operative physiotherapy. Results of a trial.


Diagnostic laboratory medicine. Leprosy.


The pattern of neurogenesis in the retina of the rat.


Myelencephalic bodies and autonomic nerve fibers of the choroid plexus in the guinea pig: a light microscopic study.


A rating scale for extrapyramidal side effects.


A controlled trial of combined medications on behavioral and extrapyramidal effects.


Handwriting changes and response to drugs--a controlled study.


A controlled comparison of the treatment of schizophrenic patients when treated according to the neurologic threshold or by clinical judgment.


Controlled studies of antiparkinsonism agents in the treatment of drug-induced extrapyramidal sympttoms.


The management of pulmonary embolic disease.


The basis of pulmonary disease resolution after nephrectomy in Goodpasture's syndrome.


Histochemical observations on the phosphatase activity of the developing dental primordia in the Swiss albino mouse as detected by azo dye and osmium-capture methods.


Factors pertaining to complete drug-induced remission of tumor in animals and man.


Further studies on serum protein formation by chimeras: induction of chimerism with a chemical carcinogen.


Clinical studies with tubercidin administered by direct intravenous injection.


The metabolic and phagocytic activities of leukocytes from children with acute leukemia.


Serial transplantation of Burkitt's tumor (EB3) cells in newborn Syrian hamsters and its facilitation by antilymphocyte serum.


Obituary: David A. Karnofsky.

Obituary: David A. Karnofsky.


Anesthetic management of patients with "a full stomach". A critical review.


The analgesic action of catecholamines and of pyrogallol.


Cytoplasmic particles and aminoacyl transferase I activity. It has been possible to show by electron microscopy of samples selected from sucrose gradients that particles of specific size and shape are present in supernatant fluids derived from nucleated animal and plant cells, but not in extracts from Escherichia coli. Aminoacyl transferase I activity in these same gradients sediments in two peaks representing material of approximately 5-7S and 18-20S. A rectangular particle, 100 x 145 A in size, sediments at 19S and coincides with the second peak of transferase I activity. The possibility that the rectangular particle may be a "carrier" particle associated with transferase I is discussed.


Activity of penicillinase in Staphylococcus aureus as studied by the iodometric method.


Fathers and sons in medicine: two of Jordan medical trio in Birmingham, one in Atlanta.


Safety in flying lies in more flying, a flying doctor declares.


Comparative energy metabolisms of some parasitic helminths.


The metabolism of 4-C14-warfarin sodium by the rat.


Fine structural changes in the nucleus induced by adenosine.


Dark and light epithelial cells in the choroid plexus of mammals.


Paired cisternae in human tumor cells.

Paired cisternae in human tumor cells.


A concept of facial esthetics.

A concept of facial esthetics.


Body composition and nutrition of school children with cerebral palsy.


Civilian vascular injuries: a critical appraisal of three decades of management.


Leucocyte group compatibility and renal allograft survival in the unmodified canine host.


Preservation and transplantation of human cadaver kidneys: a two-year experience.


Pancreatico-duodenal allotransplantation: experimental and clinical experience.


The surgical correction of ocular hypertelorism.


Long-term survival after renal transplantation in humans: (with special reference to histocompatibility matching, thymectomy, homograft glomerulonephritis, heterologous ALG , AND RECIPIENT MALIGNANCY).


Existence of the colicinogenic factor-sex factor ColI-b-P9 as a supercoiled circular DNA-protein relaxation complex.


Evidence for stable attachment of DNA to membrane at the replication origin of Escherichia coli.


The complete conversion of spermidine to a peptide derivative in Escherichia coli.


Effect of phenethyl alcohol on induction of alkaline phosphatase in Escherichia coli.


Studies on the initiation of protein synthesis in animal tissues.


An endodeoxyribonuclease induced in E. coli by infection with lambda-pbio transducing phages.


Synthesis and assembly of ribosomal proteins at the onset of pyrimidine starvation.


Repression of oxidative phosphorylation in Escherichia coli B by growth in glucose and other carbohydrates.


The Alexandrian skulls.

The Alexandrian skulls.


Assessment and significance of changes in laboratory values with haloperidol and fluphenazine hydrochloride therapy.


Sodium retention associated with intermittent positive pressure respiration.


Albumin metabolism in chronic renal failure.


A bibliography on dichotic listening.

A bibliography on dichotic listening.


Therapeutic management of certain acute and chronic soft tissue diseases of the mouth.


The use of adrenal steroids in dental practice.


A modification for orientation by the use of silicone rubber molds for embedding tissue in epoxy resins.


Sulpice Antoine Fauvel (1813-1884) French epidemiologist.


Evaporated tungsten oxide as a stripping agent for monolayer-cultured cells embedded in epoxy resins.


Epidermoid cysts simulating rheumatoid nodules in the olecranon region.


Studies in neurohypophysial endocrinology. The Sir Henry Dale lecture for 1970.


The Kokopelli.

The Kokopelli.


Dickens and doctors.

Dickens and doctors.


Problems of new drugs.

Problems of new drugs.


On the reduction of cancer mortality: Graham Crawford's experiment, 1949-1969.


John Donne (1572-1631). The case history of a poet.


Robert Drane, M.D. 1887-1970.

Robert Drane, M.D. 1887-1970.


Clement E. Kelley, M.D. 1920-1970.

Clement E. Kelley, M.D. 1920-1970.


Reticulum-cell sarcoma. 3. Prognosis.

Reticulum-cell sarcoma. 3. Prognosis.


The problem of pot.

The problem of pot.


Hydrogen ion excretion by the transplanted human kidney.


Computer analyzed thalamic potentials and their relation to expectancy waves in man.


Basal forebrain structures and sleep.

Basal forebrain structures and sleep.


Pentose cycle in isolated islets during glucose-stimulated insulin release.


Differential effect of unilateral and bilateral ECT.


Theodore Roosevelt, the asthmatic.

Theodore Roosevelt, the asthmatic.


Factors associated with poor response to lithium carbonate: a clinical study.


The treatment of anxiety and depression in the allergic patient.


Role of the adrenocortical system in suppressing anaphylaxis after hypothalamic lesion.


Sir William Osler (1849-1919).

Sir William Osler (1849-1919).


Dexamethasone acetate suspension in the treatment of allergic rhinitis.


Chicken pepsinogens and pepsins. Their isolation and properties.


Comparative studies on the effect of specific inactivators on human gastricsin and pepsin.


Mechanism of the anthranilate synthetase reaction. Evidence against an intramolecular hydrogen transfer.


Isolation and properties of a transfer ribonucleic acid deficient in ribothymidine.


Adult dental health care in England and Wales in 1968. 1. Survey plan and organization.


Precision retainers for free-end saddle dentures.


The application of transplanted tissue in oral surgery.


Educational supplement. The practice of dentistry.


Water fluoridation after 25 years.

Water fluoridation after 25 years.


Virulentization and state of bacterial surface in strains of Salmonella typhimurium.


Comparative studies on the propagation in monolayer tissue cultures of Salmonella typhimurium variants of different virulence.


Kinetics of polymerization and phosphorolysis reactions of E. coli polynucleotide phosphorylase. Role of oligonucleotides in polymerization.


The isolation of O-acetylated fragments from the K antigen of Escherichia coli 08:K27 (A):H by the action of phage-induced enzymes from Klebsiella aerogenes.


Prof. Frederic Bremer M. D. (Brussels).

Prof. Frederic Bremer M. D. (Brussels).


Theories of biological etiology of affective disorders.


The mechanism of action of hallucinogenic drugs on a possible serotonin receptor in the brain.


Drugs and body temperature.

Drugs and body temperature.


Simple peptides in brain.

Simple peptides in brain.


The activating effect of histamine on the central nervous system.


Mode of action of psychomotor stimulant drugs.


Ascending control of thalamic and cortical responsiveness.


Release of transfer ribonucleic acid from ribosomes. A G factor and guanosine triphosphate-dependent reaction.


Cyanogen bromide cleavage and partial amino acid sequence of porcine growth hormone.


Analysis of hospital bacteriological data.


Deoxyribonucleic acid biosynthesis in mitochondria. Purification and general properties of rat liver mitochondrial deoxyribonucleic acid polymerase.


Computers in bacteriology.

Computers in bacteriology.


Automation in diagnostic bacteriology.

Automation in diagnostic bacteriology.


Aggravation or initiation of megaloblastosis by amino acids in the diet.


Methotrexate therapy for Plasmodium vivax malaria.


Organizing house officers.

Organizing house officers.


House staff organizations and their demands. A threat to medical education?


Johann Friedrich Meckel, the Younger (1781-1833).


A recent case of botulism in Hokkaido, Japan.


An evaluation of the microbiology portions of the 1969 basic, comprehensive, and special College of American Pathologists proficiency testing surveys.


Conference on the medical usefulness of microbiology. Report by the Subcommittee on Medical Usefulness of the College of American Pathologists.


The immunopathology of experimental allergic orchitis.


The development and mature structure of dentine in the Pike, Esox lucius, analyzed by bright field, phase and polarization microscopy.


Transfer factor and other mediators of cellular immunity.


Howard T. Karsner, MD.

Howard T. Karsner, MD.


Mixed calcified odontogenic tumours.

Mixed calcified odontogenic tumours.


Influence of multiple injections of normal syngeneic cells on tumor induction in mice.


Histological and chemical analysis of human iliac crest cartilage. I. Observations on trunk growth.


Epizootic reticulum cell sarcoma in a sequestered colony of Japanese quails.


Characterization of a rapidly growing AKR lymphoblastic cell line maintaining Gross antigens and viral replication.


Influence of prednisolone on Moloney leukemogenic virus in BALB-c mice.


Isolation of subpopulations of lymphocytic cells by the use of isotonically balanced solutions of Ficoll. I. Development of methods and demonstration of the existence of a large but finite number of subpopulations.


Chlorpromazine and the eye of the dog. A chronic study.


Ultrastructural studies of the medial aortic sclerosis in rats with experimentally induced chronic renal disease.


Metal hip joint. A case report.

Metal hip joint. A case report.


Obituary: Willi Hoffer 1897-1967.

Obituary: Willi Hoffer 1897-1967.


Obituary: Robert Waelder 1900-1967.

Obituary: Robert Waelder 1900-1967.


Review of the literature on Diseases of the colon and rectum, January-February, 1969.


Autologous macrophage-thymocyte interactions.


Freud and H.D.

Freud and H.D.


A chronically implantable thermode for production of hypothalamic temperature waveforms.


A simple method for evaluation of cardiac output computers.


Metalloenzymes.

Metalloenzymes.


A mercury injection system for rapid anaerobic collection of small blood samples.


Motor conduction velocity studies in patients with leprosy reaction treated with thalidomide and other drugs.


Further experience with the kinetic method for the study of drugs against Mycobacterium leprae in mice. Activities of DDS, DFD, ethionamide, capreomycin and PAM 1392.


A cytochemical and radioautographic study of human tissue culture cell nucleoli. Fine structural aspects of human tissue culture cell nucleoli were studied by cytochemical and radioautographic methods. Ribonuclease and pepsin digestions were carried out on glutaraldehyde-fixed cells that, in some instances, were labeled with thymidine-(3)H prior to digestion. Double digestion by ribonuclease and pepsin revealed a fine fibrillar reticulum that appears to be the supportive structure of nucleolonemal threads. The nature of the reticulum remains to be determined. The question of whether it may represent a dispersed form of chromatin was raised. Structural findings suggested such an hypothesis but the results of radioautographic studies do not support it. The reticulum showed a striking absence of radioactive labeling following a 3 hr incorporation of thymidine-(3)H. Only few silver grains were observed occasionally in the fibrillar nucleolonema that may or may not be significant. The radioautographic results are believed to be inconclusive for the various reasons discussed. The possibility that the reticulum is composed of proteins has to be considered. It appears that basic proteins can resist pepsin digestion in aldehyde-fixed cells. Individual chromatin fibrils were found to be associated with the nucleolar reticulum. It is possible that these alone represent the dispersed genetically active chromatin of nucleoli.


Cilia and vesicular particles in the endocrine pancreas of the Mongolian gerbil. Though the general appearance and the cellular composition of the pancreatic islets of the Mongolian gerbil (Meriones unguiculatus) conformed to those of most other rodent species, some peculiar ultrastructural details were found. Thus there were diversiform, mainly vesicular particles with varying electron opacity in these islets. The vesicular particles showed a clear association to cilia which seemed to possess a basic fiber pattern of 9 + 0. The basal bodies were localized in the cytoplasm of the islet parenchymal cells, most often in the beta-cells, and the vesicular particles occurred in the portions of cilia that were protruding into intercellular spaces. The cilia were often swollen, and the vesicular particles were mainly found in the space between the ciliary membranes and the longitudinal fibers. A few vesicular particles could be seen inside and sometimes seemingly in contact with these fibers. Occasionally, there were morphologically similar structures in the cytoplasm of adjacent beta-cells. The vesicular particles were differentiated from the vesicles occurring in nerve structures by their larger size, as well as by their heterogeneous shape and electron opacity. The nature of the vesicular particles and the significance of their presence in cilia and in the cytoplasm of some of the islet cells remain unknown. Among other possibilities, it is, however, suggested that the vesicular particles may represent secretory material.


Uniformity of the solid ratio of Mycobacterium leprae from lesion to lesion.


A pilot trial of ethambutol in leprosy.

A pilot trial of ethambutol in leprosy.


Membrane modifications in nutritionally induced filamentous Escherichia coli B. Nutritionally induced filamentous cell forms of Escherichia coli B were examined for their morphological and biochemical lesions. The filamentous forms showed no significant alteration in total DNA concentration, RNA synthesis, ability to form beta-galactosidase in response to isopropylthiogalactoside, or insensitivity to actinomycin D as compared to the normal cell form. The filamentous cells showed a marked decrease in the ability to incorporate N-acetylglucosamine-UL-(14)C into a phenol-soluble glycoprotein fraction relative to the normal cell form or relative to strain E-26 of E. coli grown in the filament-inducing medium. The filaments yielded an envelope-specific phenol-soluble protein fraction markedly reduced in or lacking three proteins as determined by acrylamide gel electrophoresis. Amino acid analysis, and chemical and enzymatic treatments of the envelope-specific phenol-soluble proteins showed striking differences between the fractions obtained from normal and filamentous cells. Electron microscope studies of divalent cation-induced aggregates of the envelope proteins showed different aggregation patterns dependent upon the cell form yielding the protein fraction.


Low resistance connections between cells in the developing anther of the lily. Low resistance junctions were demonstrated between cells in anthers from young buds of Lilium longiflorum Croft by standard electrophysiological techniques. Electrodes containing a dye were used to stain impaled cells for later histological identification. Electrical coupling is widespread; germinal cells are coupled to one another; coupling is also observed between somatic elements, and germinal and somatic cells are similarly interconnected. Cytoplasmic bridges are implicated in the first case; plasmodesmata are probably responsible for the interactions in the other two. Although the physiological role of the low resistance junctions shown here and present in embryonic animal tissues is unknown, the possible function of this form of intercellular communication in the development of the anther is discussed.


Membrane splitting in freeze-ethching. Covalently bound ferritin as a membrane marker. The freeze-etch technique was used to observe red blood cell ghosts labeled on both surfaces with covalently bound ferritin. Ferritin molecules were never observed on fracture faces, thus indicating that fracture does not show membrane-surface detail. Subliming away the surrounding ice did expose the ferritin on the membrane surface. These results were consistent with the concept that membranes split during the fracture process of freeze-etching.


Demonstration of the outer surface of freeze-etched red blood cell membranes.


A new rapid method for the isolation of surface membranes  from tissue culture cells.


Antibiotic-containing enrichment media for certain Escherichia coli strains of porcine origin.


The production of oedema disease and diarrhoea in weaned pigs by the oral administration of Escherichia coli: factors that influence the course of the experimental disease.


Capsulated Haemophilus influenzae and bronchiectasis.


In memoriam. Harrison L. McLaughlin, M.D. 1906-1970.


The use of expansion meshed grafts in the acute and reconstructive management of thermal injury: a clinical evaluation.


Management of delayed union in early weight-bearing treatment of the fractured tibia.


Wolff's law in relation to the healing skin wound.


Recovery patterns and lethal manifestations of live E. coli organism shock.


Expansion mechanisms of the partially cystectomized bladder: an experimental study in rabbits.


Parameters of renal functional capacity in reversible hydroureteronephrosis in dogs. VI. Response to mannitol challenge by the chronically obstructed canine kidney and its clinical implication.


Bacteriologic and hormonal observations of the urethra and vaginal vestibule in normal, premenopausal women.


A bacteriologic and urologic evaluation of sulfamoxole.


The process of infection with bacteriophage phiX174. 8. Evidence for an essential bacterial "site". The burst of a starved bacterium infected with several øX174 bacteriophage was usually found to contain genetic traits of only one of the possible parents; less often, two phage multiplied in the same host cell. Unstarved cells, in contrast, supported the growth of at least four parental phage types. The unproductive phage seemed to be able to undergo the intracellular transition from parental single-stranded deoxyribonucleic acid to the double-stranded "replicative form" (RF). These results are taken to mean that some bacterial factor required for a step between RF synthesis and maturation of progeny is limited in starved cells.


Structure and development of rabies virus in tissue culture. Structure and development of two fixed rabies virus strains in baby hamster kidney cells (BHK/21) were investigated by electron microscopy. The morphological development was correlated with fluorescent-antibody staining and infectivity titration. The uptake of virus was enhanced by addition of diethylaminoethyl dextran, and structural changes became apparent in the cytoplasm 8 to 9 hr after infection, when fluorescent-antibody staining was first discernible. These changes consisted of matrices containing fibers replacing normal cytoplasmic structures. Virus particles appeared at the edges of these matrices and inside them at 24 to 48 hr. This corresponded to significant rises in intracellular infectious virus. Formation of virus particles by budding from cell membranes was seen at 72 hr. Further incubation of the infected cells resulted in synthesis of bizarre structural elements. The complete virus particle was bullet-shaped with an average size of 180 by 75 mmu. It consisted of an inner core of filamentous material surrounded by two membranes of different densities. The surface showed a honeycomb arrangement with surface protrusions 60 to 70 A long having a knoblike structure at their distal end. These surface protrusions were absent at the flat end of the virus particle.


Synthesis of an S-adenosylmethionine-cleaving enzyme in T3-infected Escherichia coli and its disturbance by co-infection with enzymatically incompetent bacteriophage. Synthesis of an S-adenosylmethionine-cleaving enzyme evoked by infection of Escherichia coli with phage T3 was independent of the multiplicity of infection with the wild type, T3 sam(+). It was depressed, however, by mixed infection with related phages genetically incapable of directing enzyme production, such as T3 sam(-), or phage T7. The depressor effect of enzymatically incompetent genomes depended on their proportion among the input phage and not on their absolute multiplicity. The effect was more pronounced with homologous, enzymatically incompetent phage (T3 sam(-)) than with heterologous phage (T7). After ultraviolet irradiation, enzymatically incompetent genomes lost their depressing power; at a survival level of 10(-7), no depression by either homologous or heterologous phage upon T3 sam(+)-directed enzyme synthesis was detected.


Control of bacteriophage-induced enzyme synthesis in cells infected with a temperature-sensitive mutant. The timing of "early" and "late" protein synthesis in Escherichia coli infected with T-even bacteriophage was studied with a temperature-sensitive phage mutant, T4 tsL13. This strain was completely unable to direct the synthesis of phage deoxyribonucleic acid (DNA) at 44 C because it makes a deoxycytidylate hydroxymethylase which cannot act at that temperature. However, the mutant did multiply normally at 30 C. No detectable formation of the late protein, lysozyme, occurred at 44 C, in agreement with the idea, proposed by several workers, that DNA replication is necessary for activation of late genetic functions. However, the formation of an early enzyme, thymidylate synthetase, was shut off at about 10 min, as in normal infection. This implied that separate mechanisms were responsible for cessation of early functions and activation of late ones. That the infected cell at 44 C retained the capacity for synthesis of early enzymes was shown by the fact that DNA synthesis occurred after a culture was transferred from 44 to 30 C as late as 30 min after infection. This synthesis was inhibited by chloramphenicol, indicating that de novo synthesis of an early enzyme can take place at a late period in development. It is suggested that cells infected under normal conditions maintained an appreciable rate of early enzyme synthesis throughout the course of infection.


Behavior of lambda bacteriophage in a recombination deficienct strain of Escherichia coli. The behavior of lambda phage in the Rec(-) strain JC-1569 is compared with that in the Rec(+) strain JC-1557. No difference deemed significant was noted in the adsorption rate, latent period, burst size, frequency of lysogenization, and frequency of vegetative phage recombination. The location of the prophage and its mode of insertion in the Rec(-) lysogen of wild-type lambda (lambda(+)) were inferred to be normal from the results of conjugational crosses. Spontaneous and ultraviolet (UV) irradiation induction of lambda(+) were markedly reduced in the Rec(-) lysogen. On the other hand, thermal induction of a mutant lambda (lambdacI857) lysogen of the Rec(-) strain was not reduced and was only slightly affected by UV irradiation. Phage subject to inhibition by lambda immunity failed to multiply in UV-irradiated cells of the Rec(-) lambda(+) lysogen, whereas those not inhibited by this immunity did multiply. It was concluded that the failure of UV to induce lambda(+) in the Rec(-) lysogen was not due to damage to the prophage, but rather to the inability of the irradiated cells to respond by lifting immunity. Preliminary evidence indicates that a single mutation confers recombination deficiency and the inability to lift immunity after UV irradiation. Possible relationships between recombination and the lifting of immunity are enumerated.


Infection of Serratia marcescens by bacteriophage chi.


Fluorescent cell counting as an assay method for respiratory syncytial virus. The fluorescent cell-counting technique was applied to the enumeration of cell-infecting units of respiratory syncytial (RS) virus in human fetal diploid (HFD) cover-slip cell cultures; it was a sensitive, precise, and rapid assay method. Approximately 2 hr was required for maximal adsorption of RS virus to HFD cell monolayers. However, about 15% of the infectious virus in the inoculum remained unadsorbed; this percentage was not significantly reduced even when the adsorption period was extended to 5 hr. A linear relationship between virus concentration and the number of fluorescent cells existed over a range of 1.2 log(10) units. Variation of the mean of replicate determinations in a single experiment was approximately 7.5%. The distribution of single infected HFD cells on cover-slip cell cultures corresponded with the calculated frequencies of the Poisson distribution. The Chi square test for the extent of fit was calculated for several experiments, and the value of P was never less than 0.5. The addition of immune serum after virus adsorption effectively inhibited the development of detectable levels of viral antigen in secondarily infected cells.


Primary virus-cell interactions in the immunofluorescence assay of Venezuelan equine encephalomyelitis virus. The conditions under which Venezuelan equine encephalomyelitis (VEE) virus attached to host cells markedly influenced the assay of virus by the fluorescent cell-counting technique. When virus inoculum was centrifuged onto McCoy cell monolayers, approximately 97% of virus was attached to cells within 10 min, in contrast to 34% after stationary incubation at 35 C for 2 hr. Maximal binding of virus occurred only in the presence of 0.1 to 0.15 m NaCl. This salt requirement, added to evidence of (p)H dependence and temperature independence of VEE virus attachment to cells, indicated that the initial union involved electrostatic forces. Virus penetration, measured by the insensitivity of virus-cell complexes to viral antiserum, was complete in 30 min at 35 C. The process was temperature-dependent and un-affected by the ionic content of medium. For assay of VEE virus by the fluorescent cell-counting technique, infected cells may be enumerated as early as 12 hr after infection of cell monolayers. The relationship between virus concentration and cell-infecting units was linear; the distribution of fluorescent cells was random. The virus assay was equivalent in sensitivity but more precise and rapid than that of intracerebral inoculation of mice.


Purification and chemistry of bacteriophage chi. From a stock of varkappa phage grown on Salmonella, a host-range mutant which attacks Escherichia coli was isolated. As in the case of Salmonella, only motile strains of E. coli are sensitive to varkappa. The phage shows an eclipse period of 35 min and a minimal latent period of 52 min. The adsorption rate constant is 3 x 10(-9) ml/min. Adsorption shows a marked dependence on temperature. Bacteriophage varkappa was purified by differential centrifugation and CsCl density gradient centrifugation. It contains deoxyribonucleic acid (DNA) which is double-stranded. The DNA has a molecular weight of 42 million and a guanine plus cytosine content of 57%. Of 68 molecules of DNA inspected, 7 were circular. The phage particle weight is about 90 million.


Effect of bacteriophage R17 infection on host-directed synthesis of ribosomal ribonucleates. Studies were performed on the synthesis of ribosomal ribonucleates in cells of Escherichia coli K-12 infected by the ribonucleic acid (RNA) bacteriophage R17. Host-specific RNA was measured in the presence of phage RNA by in vitro hybridization of the purified ribonucleates with E. coli deoxyribonucleic acid. The results showed that, although the overall rate of RNA synthesis was only slightly affected by phage infection, the level of host RNA synthesis was decreased by 70 to 80%. Fractionation of the purified ribonucleates by sucrose gradient sedimentation, followed by hybridization of fractions sedimenting in the 23S and 16S regions, revealed that the level of ribosomal RNA synthesis was also decreased by 70 to 80%, and that this inhibition occurred during the first 15 to 20 min after infection. These findings are discussed in light of what is known about the inhibition of host RNA synthesis by other virus systems.


How bacteriophage chi attacks motile bacteria. Bacteriophage chi attaches to the filament of a bacterial flagellum by means of a tail fiber, but the ultimate receptor site for the phage is located at the base of the bacterial flagellum. Here, the phage injects its deoxyribonucleic acid into the bacterium, leaving the empty phage attached at the base. It is suggested that chi slides along the filament of the flagellum to the base, owing to the movement of the flagellum. The role of motility would thus be to provide for rapid adsorption of the phage by guiding the phage to the adsorption sites at the bases of the flagella. Bacteria whose motility has been strongly inhibited by cold or anaerobic conditions still adsorb chi at the filaments and bases of flagella if a high multiplicity is used. This indicates that direct collisions with the bases may also be possible. Bacteria must be flagellated in order for chi to attach, but only a short flagellum, perhaps only the flagellar base, is necessary.


Bacteriuria during indwelling catheter drainage. II. Effect of a closed sterile drainage system.


Virological, immunochemical, and cytochemical studies of four HeLa cell lines infected with two strains of influenza virus. The production of infectious virus, hemagglutinin, and viral (V) antigens and the changes in ribonucleoprotein (RNP) and lipoprotein metabolism have been studied in four sublines of HeLa cells infected with the PR8 and a PR8 recombinant strain of influenza virus. Much greater amounts of infectious virus and much less hemagglutinin were produced by the PR8 recombinant than by PR8 virus in all four cell lines. Different amounts of infectious virus per infected cell were produced by the recombinant in the four cell lines, whereas very little infectious virus was produced by the PR8 strain in any of the HeLa cells. In all cell lines infected with both strains of virus, "soluble" (S) antigen appeared early in the nucleolus. In cells infected with PR8 recombinant, S antigen subsequently filled the nucleus and later appeared in the cytoplasm. In most cells infected with PR8 virus, nuclear S antigen did not fuse to fill the nucleus, and S antigen was not detected in the cytoplasm. V antigen was observed in the cytoplasm of cells when diffuse nuclear S antigen had formed. The earliest and most frequent change in the RNP of the infected cells was a decrease in stainable RNP spherules (nucleolini) in the nucleolus. This was followed, in a smaller proportion of cells, by the appearance of nuclear and cytoplasmic inclusions containing RNP. There was a characteristic difference in the morphology of the cytoplasmic inclusions produced by the two strains of virus, but the same types of inclusions were observed in all four HeLa lines. A significant increase in lipoprotein was observed only in association with the cytoplasmic inclusions produced by PR8 recombinant virus. There was a striking difference in the proportion of cells with cytochemical changes in RNP in the four cell lines. A significant cytopathic effect (CPE) was observed only in three virus-cell systems in which a high proportion of cells exhibited changes in nucleolinar RNP. It is suggested that disappearance of RNP in the nucleolini may be an indication of shutdown of host ribonucleic acid synthesis and that this in turn results in a CPE. Virus infection resulted in a C-mitotic block that was followed by karyorrhexis. Infection of the cell did not always result in the production of infectious virus, in changes in the RNP of the nucleolini, in the development of nuclear or cytoplasmic RNP inclusions, or in CPE. The results suggest that production of infectious virus, shutdown of cellular RNP synthesis with accompanying CPE, and the formation of inclusions appear to be independent events.


The future care of tuberculosis patients.


Antibiotics and hepatic artery ligation in germfree and conventional dogs.


Raymond Sabouraud (1864-1938) French dermatologist.


Linear calcification of the ascending aorta without syphilis.


Medicare.

Medicare.


Experimental measles virus encephalitis. A light, phase, fluorescence, and electron microscopic study.


Advances in indicator dilution techniques applicable to studies of the acutely ill patient.


Role of synalbumin insulin antagonist in pathogenesis of diabetes mellitus.


Effects of 6-N-allyladenosine on bacterial and mammalian cells.


Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction. Deductions concerning the conformation of methionine.


Professor W.O. Kermack.

Professor W.O. Kermack.


History of biochemistry and molecular biology.


Synthesis of 5S ribosomal RNA in Escherichia coli after rifampicin treatment.


Nucleic acid structure function relations.


Specific inhibition of nuclear RNA polymerase II by alpha-amanitin. alpha-Amanitin, a toxic substance from the mushroom Amanita phalloides, is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus. This compound exerts no effect on the activity of polymerase I (nucleolar form) or polymerase III (also nucleoplasmic). The inhibition is due to a specific interaction with polymerase II or with a complex of DNA and polymerase II.


Electrical coupling: low resistance junctions between mitotic and interphase fibroblasts in tissue culture. Dividing cells of chick embryonic fibroblasts and of mouse embryonic fibroblasts (3T3) in tissue culture are electrically coupled to their interphase neighbors. Recordings from many such cells suggest that this coupling persists throughout the division cycle of the mitotic cell.


Primary malignant neoplasms of the small intestine.


A detailed study of the cardiopulmonary response to ketamine and its blockade by atropine.


A surgeon's appraisal of ketamine.

A surgeon's appraisal of ketamine.


The histological localization of squash mosaic virus in cantaloupe seedlings.


Biotin-transducing lambda phages with unusual att regions.


Electron microscopic observations on fd bacteriophage, its alkali denaturation products and its DNA.


Protein synthesis and the arrest of bacterial DNA synthesis by bacteriophage phi-X174.


Reversible inactivation of T4 ts DNA polymerase mutants in vivo.


The relationship between the synthesis of DNA and the synthesis of phage lysozyme in Escherichia coli infected by bacteriophage T4.


Prophage deletions selected by heat induction of bacteria lysogenic for lambda-int6CI857.


The correlated occurrence of duplications and deletions in phage T4.


Immunofluorescent demonstration of double-stranded RNA in the cytoplasm of Sindbis virus-infected cells.


Interference by bacteriophage T4 in the reproduction of the single-stranded DNA phage M13.


Three cistrons in bacteriophage Q beta.

Three cistrons in bacteriophage Q beta.


Intraventricular block: physiologic considerations of clinical relevance.


Respiratory acidosis.

Respiratory acidosis.


Salmonellosis.

Salmonellosis.


Epizootiology.

Epizootiology.


Gaubius on inflammation. I.

Gaubius on inflammation. I.


Pasteurellosis: Pasteurella multocida and Pasteurella hemolytica.


Nonfermentative bacilli associated with man. II. Detection and identification.


Alcoholism, illness, and social pathology among American Indians in transition.


A selected public health bibliography with annotations.


The central x-ray beam in stereotaxis.

The central x-ray beam in stereotaxis.


Acquired nonmalignant esophagotracheal and esophagobronchial fistulas.


Tetralogy of Fallot.

Tetralogy of Fallot.


Ovulation induced by autologous pituitary extracts in androgen and light-sterilized rats.


Diagnosis of pemphigus.

Diagnosis of pemphigus.


The isolation and immunochemical activity of rabbit gamma M- and gamma G-antibodies against the common enterobacterial antigen.


Circulating rheumatoid and antinuclear factors in asbestos workers. In an unselected series of 80 patients with asbestos exposure referred to the London Pneumoconiosis Medical Panel, antinuclear and rheumatoid factors were found in 28 and 27% respectively. This probably represents at least a fourfold increase over their incidence in random populations. The presence of these autoantibodies was not related to the duration of exposure, but was related to the extent of radiographic abnormality.


Passaic County Dental Society Membership Roster 1970-1971.


Milk allergy in infants and young children. Current knowledge.


Mothering and Frederick II.

Mothering and Frederick II.


Schizophrenic thought disorder: a review and hypothesis.


Hydroxyzine and chlordiazepoxide in anxious neurotic outpatients: a collaborative controlled study.


An approach to atrophic ridges. Extension by  skin grafting or secondary epithelization.


Evaluation of the survival gain in 22 measurable lung tumors treated with chemotherapy. An approach towards quantitative evaluation of cancer treatments in man.


Biochemistry of cervical mucus.

Biochemistry of cervical mucus.


Cerebral protein synthesis inhibitors block long-term memory.


Combination of clindamycin and ampicillin "in vitro".


Celsus on geriatrics.

Celsus on geriatrics.


[Preferential inhibition of the growth of Escherichia coli strains carrying episomes].


Studies on the drug resistance of Staphylococci and Escherichia coli against antibiotics. II. General tendency of resistant strains.


Congenital absence of hypoplasia of the endocrine glands.


Carbenicillin: clinical and laboratory studies.


The in vitro inhibition of insulin secretion by diphenylhydantoin. Glucose intolerance has been observed following diphenylhydantoin (DPH) intoxication. Because of this association between DPH and hyperglycemia, the effect of DPH on insulin release in vitro using preparations of isolated islets of Langerhans and pancreatic pieces was examined. In concentrations identical with those considered necessary for adequate anticonvulsant therapy in man, DPH markedly decreases the insulin secretory response of pancreatic pieces to methacholine, 1 mug/ml, tolbutamide, 250 mug/ml, and glucose, 200 mg/100 ml, without any demonstrable alteration in the oxidative conversion of glucose-1-(14)C or glucose-6-(14)C to (14)CO(2) by isolated islets. This DPH-induced inhibition of insulin secretion is not reversed by higher concentrations of glucose (600 mg/100 ml) or by increasing concentrations of extracellular calcium ion (4-6 mmoles/liter). 0.1 mM potassium and 10(-4) M ouabain, however, effectively restore the DPH-induced block of insulin secretion in pancreatic pieces. 60 mM potassium ion, on the other hand, not only restores the insulin secretory response to glucose (200 mg/100 ml) but results in an added stimulation of insulin secretion in the presence of DPH. In the presence of DPH, (22)Na accumulation by isolated islets is decreased by 26-40% as compared with controls. Such evidence is considered to indirectly support the postulate that the electrophysiological properties of DPH on the pancreas are due to a stimulation of the membrane sodium-potassium-magnesium ATPase.


Fathers and sons in medicine: 7 Stablers have practiced or will practice in Greenville.


The role of carbenicillin in treatment of infections of the urinary tract.


Recurrent snuff dipper's lesion treated by excision and skin graft: report of case.


Problems concerning the uterine causes of embryonic death, with special reference to the effects of ageing of the uterus.


An adventure in articulators.

An adventure in articulators.


District rsing: a brief history.

District rsing: a brief history.


Hemodynamic and metabolic abnormalities in septic shock.


Location of the genes for 16S and 23S ribosomal RNA in the genetic map of Escherichia coli. By means of RNA-DNA hybridization with DNA from different merodiploids of Escherichia coli, the genes for 16S and 23S ribosomal RNA were found near minute 74 of the genetic map.


Pharmacology and molecular biology of cancer chemotherapy.


The activation of gastric acid secretion by insulin hypoglycaemia.


Effect of storage on peptic activity of human gastric juice.


Genetic factors in drug therapy.

Genetic factors in drug therapy.


Congenital and acquired chest deformities in children.


Common denture complaints, detection and correction.


A closed mouth impression technique--for the stabilization of full dentures.


Mercer Dental Society 1970-1971 membership list.


Ultrastructure of the Cercarienhüllen Reaktion of Schistosoma mansoni.


Metabolic myopathies.

Metabolic myopathies.


Immunological studies in subacute sclerosing panencephalitis.


A reassessment of Max Wertheimer's contribution to Psychological Theory.


Douglas Sheldon Kellogg, M.D. 1899-1969.


VA dental fee schedule. (Effective as of July 1, 1970).


Recent progress in some aspects of the physiology of parasitic protozoa.


The unique friendship of Theodor Billroth and Johannes Brahms.


A multiparameter study on the action of preparations containing cholecystokinin-pancreozymin.


The azygos circulation time and mechanism of varix rupture in portal hypertension.


Simultaneous bilateral posterior nephrectomy in transplant recipients.


An endogenous source for wound infections based on quantitative bacteriology of the biliary tract.


Blood loss in orthopedic operations: comparative studies in 19 major orthopedic procedures utilizing radioisotope labeling and an automatic blood volume computer.


Hepatic ultrastructural response to endotoxin shock.


Acute respiratory pathophysiology after hemorrhagic shock.


Changes in canine venous volume and pressure during hemorrhage.


Plastic drapes in open-skin grafting.

Plastic drapes in open-skin grafting.


Timely topics in microbiology: gram negative bacteria.


Relapses of endocarditis due to the same phage type of enterococcus.


Refractive keratoplasty.

Refractive keratoplasty.


Penetrating keratoplasty in an infant with sclerocornea.


Obituary. Gertrude Rand 1886-1970.

Obituary. Gertrude Rand 1886-1970.


The New York Eye and Ear Infirmary sesquicentennial celebration.