Factors affecting the production of MS2 RNA phage.


The surgical treatment of abnormal involuntary movements.


Gold leaf in urologic surgery: an experimental study.


Simplified bowel anastomosis: a method of shortening ileal diversion time.


Patency of major renal vascular pathways demonstrated by rapid blood flow scintiphotography.


MDs and administrators tell Medicare-Medicaid failures.


Adapting social measurement for special population groups.


Computerised medicine in America.

Computerised medicine in America.


Regeneration of the skull following a deep electrical burn.


A bi-hinged chest-arm flap for lymphedema of the upper limb.


The organogenesis and arrangement of cutaneous appendages in birds.


A list of original and classical descriptions of neurological diseases, signs and syndromes with their historical notes. 1.


Macromolecular syntheses and nucleocytoplasmic interactions in early development.


The kinetics of tumour cell proliferation and radiotherapy.


A preliminary design and trial of an artificial human tube.


The physiology and pharmacology of epidural blockade.


Enrico Greppi.

Enrico Greppi.


Gamma-methylthiobutyric acid as a growth stimulant.


Disposable fiberglass filter to counter bacterial contamination of intermittent positive pressure breathing equipment.


Some aspects of the digestion of proteins.


Socrates' defence of civil obedience.

Socrates' defence of civil obedience.


Ophthalmologic observations on long-term survivors after radiotherapy for nasopharyngeal tumours.


Radiation for immunosuppression in human organ transplantation. I. Experimental data.


Autoimmune thrombocytopenic purpura.

Autoimmune thrombocytopenic purpura.


Virulent and avirulent Leptospires: biochemical activities and survival in blood.


Immunity to Escherichia coli in pigs: effect of feeding colostrum or serum from vaccinated sows to Escherichia coli infected gnotobiotic pigs.


Isolation of mycoplasma from goats during an epizootic of keratoconjunctivitis.


Emergence of resistant organisms as a function of dose in oxolinic acid therapy.


Immunity to Escherichia coli in pigs: serologic response to sows given formalin-treated live Escherichia coli vaccine.


Amino acid accepting activity of deacylated peptidyl-tRNA.


The effects of diamines and polyamines on enzymic methylation of nucleic acid.


Ribosomal protein synthesis during recovery from puromycin treatment.


Accidental intravenous injection of halothane. Case report.


Pulmonary oedema associated with sodium retention during ventilator treatment.


Ureteral function in vesico-ureteral reflux.


Cyclophosphamide necrosis of bladder causing calcification, contracture and reflux; treated by colocystoplasty.


Donald Dexter Van Slyke 1883-1971.

Donald Dexter Van Slyke 1883-1971.


Validity and reproducibility of determination of cardiac output by thermodilution in man.


Serum immunoreactive insulin levels during glucose tolerance and intensive islet stimulation.


Anti-pancreatic cellular hypersensitivity in diabetes mellitus.


Serum immunoreactive insulin levels during glucose tolerance and intensive islet stimulation. Effect of prednisone.


Intestinal microflora.

Intestinal microflora.


James Bain Carey, Jr. 1924-1970.

James Bain Carey, Jr. 1924-1970.


Relationship of defense mechanisms to field dependence-independence.


Bolus-augmented continuous injection of indicators for cardiac output.


A computer program to estimate cardiac output directly from dye-dilution curves.


Computation of transit time distributions using sampled data Laplace transforms.


Tissue-specific mitotic inhibition in the kidneys of embryonic grafts and partially nephrectomized host Xenopus laevis.


Doctor Gigli's saw and the closed mandibular osteotomy: an appraisal, a variation, and a report of case.


The Alfred Hospital centenary.

The Alfred Hospital centenary.


The making of a hospital history. Some problems in research and interpretation.


The economics of computerized clinical medical practice.


Strategy of Qbeta phage replication.

Strategy of Qbeta phage replication.


Relation of Holtzman scores to rigidity.


Adrien Barrère. A French medical caricaturist.


Current bibliography on allergy and applied immunology.


Transport of amino acids and peptides in the gut and the kidney.


Immunity to malignant disease in man.

Immunity to malignant disease in man.


Regulation by insulin of protein and amino acid metabolism.


Biochemical compensation in anaemia.

Biochemical compensation in anaemia.


Experimental cholelithiasis.

Experimental cholelithiasis.


The ageing eye.

The ageing eye.


Some recent work on glaucoma.

Some recent work on glaucoma.


Physiological measures in psychiatry.

Physiological measures in psychiatry.


The physiology of intravenous urography.


The present status of the fluoridation question.


The lymph-borne cells of the immune response: a review.


Extended therapy in patients with established urinary tract infection.


Ocular myopathy.

Ocular myopathy.


Diagnosis of dysthyroid exophthalmos.

Diagnosis of dysthyroid exophthalmos.


Corneal oedema from corneal contact lens wear, its causes and treatment.


Fluorescein angiography of the globe and anterior segment.


Corneo-scleral transplantations.

Corneo-scleral transplantations.


Lamellar corneo scleral grafts.

Lamellar corneo scleral grafts.


A study of the ocular complications of hydrocephalus and meningomyelocele.


The aetiology of macular oedema.

The aetiology of macular oedema.


Plastic surgery and the eye.

Plastic surgery and the eye.


Current trends in the treatment of central venous thrombosis.


Streptomyces sp. producing litmocidin.

Streptomyces sp. producing litmocidin.


Keratoprosthetics.

Keratoprosthetics.


Cellular reaction in photosensitivity with reference to lysosomal enzymes. (A brief review on recent concepts).


Quantitative theory of in vivo lac regulation: significance of repressor packaging. I. Equilibrium considerations.


Spinal sympathetic reflexes initiated by coronary receptors. 1. The main left coronary artery of vagotomized spinal cats was perfused at different flows and pressures. The changes in pressure were limited to the coronary bed.2. Increased coronary flow which increased coronary arterial pressure provoked a reflex increase in sympathetic discharge in the white ramus of the third thoracic spinal nerve and the inferior cardiac nerve. Reflex reductions in activity were not observed.3. Occlusion of the coronary sinus and myocardial ischaemia, due to cessation of pump inflow, evoked similar reflex increases of sympathetic activity. The effect of myocardial ischaemia was apparent before systemic arterial blood pressure fell or left ventricular end-diastolic pressure rose.4. Increased coronary arterial pressure, myocardial ischaemia and coronary sinus occlusion could activate the same preganglionic neurone.5. The afferent limb of the excitatory coronary-sympathetic reflex was in the cardiac sympathetic nerves, mainly on the left. Afferent nerve fibres running in these nerves and in the third left thoracic sympathetic ramus communicans were excited by increased coronary arterial pressure, myocardial ischaemia, and occlusion of the coronary sinus. Inhibition was not observed. Many of the receptors were further localized by direct probing over the coronary vessels and adjacent myocardium.6. Some receptors were excited by increased coronary arterial pressure alone, others by coronary sinus occlusion, and still others by myocardial ischaemia. In addition, some receptors were excited by all three stimuli.


Kidney preservation for transportation. 6. A new perfusate applied to human cadaveric kidneys.


Kidney preservation for transportation. 5. Comparison of perfusates for hypothermic storage.


Dipslide screening of hospitalized patients for bacteriuria.


Alfred Charles Thomas.

Alfred Charles Thomas.


Fluorescein-labelled Salmonella typhi antigen for detection of antibody in spleen cells of protein-depleted rabbits injected with the same antigen not labelled.


The production of farmer's lung antigens.


Rapid decalcification of bone for diagnostic histology.


Changes of activity of proteolytic enzymes in blood and urine of whole-body x-irradiated animals.


Subtle immunologic abnormalities in four boys with subacute sclerosing panencephalitis.


The controls of gastrointestinal movements: some old and new views.


Method for estimation of liver weight in situ from the ratio of hepatic blood flow measured by colloidal radiogold (198 Au) and radioxenon (133 Xe) clearance. Experimental studies in dogs.


[Experimental bilio-lymphatic reflux in basal conditions. Histological study].


Erythropoiesis.

Erythropoiesis.


Treatment of functional dysmenorrhea; a double-blind study.


Effects of salicylates on the gastric mucosa as revealed by roentgen examination and the gastrocamera.


Evaluation of surgery for mitral valve disease.


Eisenmenger complex.

Eisenmenger complex.


Oxygen in ischemic heart disease.

Oxygen in ischemic heart disease.


A source of pride.

A source of pride.


Sutures and wound healing.

Sutures and wound healing.


First fifty years.

First fifty years.


Cell recognition by multivariate gray value analysis in digitized images.


Some remarks on the patient suffering from Méniére's disease.


In vitro observations of sex chromatin in cells from the human uterine cervix.


Cataracts and primary open-angle glaucoma: the effect of uncomplicated cataract extraction on glaucoma control.


Cell culture propagation of neonatal calf diarrhea (scours) virus.


Surgical management of cerebral arterial insufficiency.


Space closure following loss of lower first premolars.


Tennessee Dental Association directory and membership roster 1971-72.


Regression of bovine lymphosarcoma.

Regression of bovine lymphosarcoma.


Bacteriological and epidemiological approach to prophylaxy for enteric infection. II. Antagonism of dysentery bacilli on the cultured cell infection.


Studies on murine leprosy bacillus. I. Attempt to cultivate in vitro the Hawaiian strain of Mycobacterium lepraemurium.


Bacteriological and epidemiological approach to prophylaxy for enteric infection. I. Invasion mechanism of Shigella into cultured cells.


Computers and paraprofessionals. A strategy for effective health care delivery.


A review of image processing in biology and medicine.


Studies on patients with renal artery stenosis (the diagnostic value of plasma renin activity measurements).


Hereditary disorders of blood coagulation due to defective and deficient synthesis of protein.


Investigations into the pathogenesis of diarrheal diseases.


Myasthenia gravis--the first 100 years in perspective.


Gustav Mahler and his illnesses.

Gustav Mahler and his illnesses.


Memorial. Paul A. Bunn, M.D.

Memorial. Paul A. Bunn, M.D.


Starvation and body nitrogen.

Starvation and body nitrogen.


The occurrence of substances in human serum which can regulate porphyrin synthesis in liver cells.


Bile acid excretion patterns in patients with diarrhea.


The digestive tract of cells.

The digestive tract of cells.


Memorial. Edward Harvey Cushing, M.D. (1898-1969).


The first annual meeting of the American Climatological Association.


Memorial. John Bamber Hickam, M.D.

Memorial. John Bamber Hickam, M.D.


Memorial. Henry Dexter Chadwick, M.D.

Memorial. Henry Dexter Chadwick, M.D.


Symposium. The role of serum antibodies in malarial immunity. The detection and measurement of malarial antibodies.


Thomas Gage and tropical medicine in the New World.


Serum antibody in acquired malarial immunity.


Biology of Nanophyetus salmincola and "salmon poisoning" disease.


Relationships between the species of Fasciola and their molluscan hosts.


Fascioliasis: the invasive stages in mammals.


Lilian Lindsay, 1871-1960.

Lilian Lindsay, 1871-1960.


Quinidine in maintenance of sinus rhythm after electroconversion of chronic atrial fibrillation. A controlled clinical study.


Epithelial-endothelial interaction in the control of inflammation through fibrinolysis.


"Catharsis": an excretory function of the epidermis.


IgD in various dermatoses; immunofluorescence studies.


Vesico-ureteric reflux after renal transplantation. The uretero-vesical junction has been examined by micturating cystography in 20 patients after renal transplantation. Intravenous pyelograms were used to investigate the upper urinary tract in 13 of the patients. Persistent urinary infection did not occur in patients without vesico-ureteric reflux. However, both those with reflux of their own and the transplant ureters had persistent infection. When reflux affected the tunnelled transplanted ureter there was no infection, but two patients without a tunnel implant had a persistent urinary infection.


Clinical evaluation of a rosette inhibition test in renal allotransplantation. The formation of spontaneous rosettes by peripheral blood or spleen mononuclear cells when incubated with sheep red blood cells has proved a useful way of assessing the potency of immunosuppressive drugs and antilymphocyte sera in vitro. A test employing the inhibition by antilymphocyte globulin (A.L.G.) of spontaneous rosette formation around peripheral blood mononuclear cells is described. This has been used to assess the degree of immunosuppression in patients with renal allografts and uraemic patients on regular haemodialysis.Twenty-three patients with renal allografts had 21 clinically diagnosed episodes of rejection. In none of these rejection episodes was the minimal inhibitory concentration (M.I.C.) of A.L.G. (that necessary to reduce the spontaneous rosette formation of peripheral cells by 75%) less than 1/50,000. Nineteen patients had no rejection episodes during 57 patient/months of continuous observation while the M.I.C. was at a greater dilution than 1/50,000. The test has therefore been of great value in suggesting when an individual is capable of rejecting his graft, and allows the dose of immunosuppressive drugs to be adjusted to a minimum in a controlled fashion. It has been of use in diagnosing rejection in the anuric patient, when the distinction between rejection, urinary tract obstruction, and infection is particularly difficult.Fifteen patients maintained on regular haemodialysis for more than a year had, as judged by this technique, less reactive lymphocytes than normal healthy controls. The degree of immunosuppression was not as great as in the patients on full immunosuppressive regimens.


Sir Alan Moncrieff C.B.E., M.D., F.R.C.P., F.R.C.O.G.


Controlled comparison of the efficacy of fourteen preparations in the relief of postoperative pain. Thirteen analgesic drugs, four of them at two dose levels, four analgesics in combination with antagonist or neuroleptic agents, and saline have been evaluated simultaneously in the relief of postoperative pain. The method of assessment was designed to favour drugs which provided freedom from pain with minimum depression of consciousness. Only levorphanol 2 mg proved significantly superior to pethidine 100 mg, which was used as the standard reference drug. Oxycodone 10 mg, pentazocine 20 mg, and the morphine 10 mg and cyclizine 50 mg combination were the most successful of the remaining drugs. None of the drug combinations was significantly better than the analgesic drug given alone.


Bone graft into anterior arch defect of lower jaw: report of a case.


Derepression of F-lac in Salmonella typhimurium by a determinant for kanamycin resistance.


Non-essentiality of the recA- mutation in the phenomenon of bacteriophage M13-induced elimination of F' factors. The elimination of F' factors promoted by coliphage M13 infection can occur in recA(+) as well as recA(-) merodiploid strains of Escherichia coli K-12.


Extrachromosomal nature of hydrogen sulfide production in Escherichia coli. Two strains of Escherichia coli which produce hydrogen sulfide appear to have acquired this ability via transfer of genetic material from another genus.


Variability of photodynamic killing in Escherichia coli and avoidance of variability with agar. Photodynamic killing of Escherichia coli in acridine orange is influenced by the composition of the containing vessel, and after high kill the variance between replicate suspensions is greater than attributable solely to sampling and plating. Addition of agar minimizes both phenomena, but a higher illumination dose is required to produce the same degree of killing.


Differences between Escherichia coli B-r and Salmonella typhimurium LT-2 in the sedimentation behavior of the deoxyribonucleic acid synthesized after x-irradiation. After irradiation, nearly equal amounts of deoxyribonucleic acid (DNA) are synthesized in radiation-sensitive Salmonella typhimurium and in resistant Escherichia coli B/r. However, the DNA synthesized in S. typhimurium is of low molecular weight, whereas that made in the E. coli B/r is like that synthesized in the unirradiated controls.


Major research events in pharmacology, 1940-1970.


Induction of colicin 1a at high temperature. Induction of colicin la at a high temperature (42 C) was demonstrated in a wild strain of Shigella sonnei. After transfer of the Col factor, a similar effect was observed in those recipient cells acquiring colicinogeny. The induction is suggested to be due to the presence of a thermosensitive colicin repressor. The wild-type strain segregated sensitive cells and showed heterogeneity in colicin production.


Transport of vitamin B 12 in Escherichia coli. The uptake of (60)Co-labeled cyanocobalamin (vitamin B(12)) by cells of Escherichia coli K-12lambda was shown to consist of an initial rapid phase (complete in <1 min), followed by a slower secondary phase. Methods enabling the measurement of (60)Co-B(12) uptake after incubation times of 1 to 2 sec were used in studies on the initial rate of B(12) uptake. This initial process showed saturation kinetics, with a V(max) of 56 molecules per sec per cell and a K(m) of 5 nm, and was essentially independent of cellular energy metabolism. No inhibition was obtained with cyanide, fluoride, arsenite, or 2, 4-dinitrophenol, and an energy of activation of 3.8 kcal/mole for this initial phase of uptake was calculated from its response to temperature changes between 15 and 35 C. The inhibition by HgCl(2) (50% at 0.1 mm) but not by 1 mmN-ethylmaleimide or 1 mmp-chloromercuribenzoate was consistent with a role for a relatively inaccessible sulfhydryl residue at the initial B(12) binding site. The secondary phase of B(12) uptake was clearly dependent on the energy metabolism of the cell, and, from its response to temperature, an energy of activation of about 17 kcal/mole was calculated. Cyanide (10 mm), arsenite (10 mm), and 2, 4-dinitrophenol (0.1 mm) gave at least 70% inhibition of the rate of the secondary phase. The formation of other cobalamins, such as 5'-deoxyadenosyl cobalamin, was not an obligate part of B(12) transport. The cells were also able to take up (60)Co-labeled cobinamide cyanide.


Promoter-like mutant with increased expression of the glycerol kinase operon of Escherichia coli. A glycerol-specific phenotypic revertant isolated from a mutant of Escherichia coli missing enzyme I of the phosphoenolpyruvate phosphotransferase system was studied. This revertant is capable of producing higher levels of glycerol kinase and the protein mediating the facilitated diffusion of glycerol (facilitator) than wild-type cells. The kinase of the revertant is indistinguishable from the wild-type enzyme with respect to its sensitivity to feedback inhibition by fructose-1,6-diphosphate, its pH optimum, and its turnover number. The synthesis of glycerol kinase in strains bearing the suppressor locus is resistant to catabolite repression. The suppressor mutation mapped at the known glpK locus. Thus, it is suggested that the mutation occurred in the promoter of the operon specifying the kinase and the facilitator.


Nutrition and infection.

Nutrition and infection.


Phenylalanine biosynthesis in Escherichia coli K-12: mutants derepressed for chorismate mutase P-prephenate dehydratase. Mutants were isolated which are derepressed for the synthesis of chorismate mutase P-prephenate dehydratase. No other enzymes involved in the synthesis of phenylalanine are derepressed in these strains. These mutants are able to grow in concentrations of o- and p-fluorophenylalanine that inhibit the growth of AB3259, the strain from which they were derived. They also excrete phenylalanine. Genetic analysis shows that the mutations causing this derepression are closely linked to the structural gene for this enzyme (cotransduction frequency of 95% or more with pheA). The gene in which they occur has been designated pheO since this gene has all of the properties predicted for an operator gene controlling the pheA structural gene. Finally, the pheO mutant alleles have been shown to be dominant in diploids.


Temperature sensitivity of maltose utilization and lambda resistance in Escherichia coli B. Escherichia coli B strains that have acquired the malB region from E. coli K-12 are able to utilize maltose and to adsorb phage lambda when grown at 30 C, but when grown at 40 C they do not absorb phage lambda and are devoid of amylomaltase activity. These Mal(ts) Lam(ts) cells can be mutated or transduced to become able to grow on maltose at 40 C, but they still have no detectable amylomaltase activity nor functional lambda receptors at that temperature. This Mal(40) phenotype is governed by a gene located near or at malA. It is suggested that the temperature sensitivity of both characters results from a defect in malT. However, transduction of malA from E. coli B to E. coli K-12 results in a wild-type phenotype, whereas E. coli B cells that have acquired malA from E. coli K-12 donors are still temperature sensitive for both amylomaltase and lambda-receptor production.


Auxotroph accumulation in deoxyribonucleic acid polymeraseless strains of Escherichia coli K-12. Spontaneous auxotrophs are found with high frequency in several strains of Escherichia coli K-12 deficient in Kornberg deoxyribonucleic acid polymerase. These include amino acid-, vitamin-, purine-, and pyrimidine-requiring strains. Although this was suggestive evidence that these strains might be mutators, reconstruction experiments demonstrate that auxotrophs possess a selective advantage over prototrophs in the same culture. Thus, despite the high frequency of auxotrophs in polymerase-deficient strains, it is not yet clear whether they have elevated mutation rates.


Regulation of thymidine metabolism in Escherichia coli K-12: studies on the inducer and the coordinateness of induction of the enzymes. A study was made of the regulation of three enzymes that act sequentially in the metabolism of thymidine in Escherichia coli K-12. Under a variety of conditions, two of the enzymes, thymidine phosphorylase and deoxyribose-5-phosphate aldolase, were found to be synthesized coordinately. However, the third enzyme, phosphodeoxyribomutase, was synthesized noncoordinately with the other two enzymes under the same conditions. In addition, the mutase could be fully induced, whereas basal levels of the phosphorylase and the aldolase were maintained. These findings indicate that two operons comprise the genes concerned with the reversible pathway leading from thymidine to acetaldehyde and glyceraldehyde-3-phosphate. In addition to thymidine, it was found that acetaldehyde was an external inducer of these enzymes. The results of induction experiments performed on wild-type cells and mutants defective in the mutase or the aldolase, with thymidine or acetaldehyde as exogenous inducers, strongly suggest that deoxyribose-5-phosphate is more proximal to the intracellular inducer than is thymidine, deoxyribose-1-phosphate, or acetaldehyde.


Mode of action of the competence-inducing factor of Bacillus stearothermophilus. Development of competence in the noncompetent mutant of Bacillus stearothermophilus 4S requires a soluble competence-inducing factor (CF). This study describes several observations that define the mechanism of action of this factor. (i) CF interacts with cells, protoplasts, or cytoplasmic membranes in a temperature-dependent reaction; incubation of CF with cells alters the sedimentation properties of the cells. (ii) Association between CF and the cytoplasmic membrane appears to be the first and rate-limiting step in the process of transfection with deoxyribonucleic acid (DNA) from bacteriophage TP-IC. (iii) The membrane-CF complex is capable of removing infectious DNA from the supernatant fraction in vitro. (iv) Twenty phage-resistant mutants are unable to undergo the above reactions. A model is developed in which CF serves as a dynamic mediator of the reaction between the transfecting DNA and the cell surface.


Role of pyridine nucleotides in 5-fluorouracil-mediated reactivation of ultraviolet radiation damage. Ultraviolet irradiation (520 ergs/mm(2) at 254 nm) causes the respiration of Escherichia coli B/r cells to cease after about 90 min postirradiation incubation in a minimal medium containing glycerol as the sole source of carbon. The cessation of respiration is associated with loss of pyridine nucleotides. Agents which interfere with postirradiation transcription and translation prevent cessation of respiration. We have studied the effects of one of these agents, 5-fluorouracil (FU), on respiration, pyridine nucleotide levels, viability, capacity to support phage growth, and the repair of irradiated deoxyribonucleic acid (DNA). Addition of FU to cells immediately after irradiation results in the continuance of respiration at a linear rate and the maintenance of high levels of pyridine nucleotides. Cellular viability increases dramatically during the first 60 min of postirradiation incubation in the presence of FU. The ability of irradiated cells to support the growth of phage T4 is also greatly increased. FU treatment has no effect on the kinetics of pyrimidine dimer excision or the degradation of DNA. However, treated cells repair single-strand breaks resulting from early steps in excision repair slightly more efficiently than do untreated cells. The results support the hypothesis that one of the causes of death in these irradiated cells is the disappearance of pyridine nucleotides, coenzymes of certain respiratory dehydrogenases, and, in the case of nicotinamide adenine dinucleotide, for polynucleotide ligase, the enzyme responsible for the final step in the repair of DNA.


Factors affecting transfection in Bacillus stearothermophilus. The conditions for the infection of Bacillus stearothermophilus 4S with TP-1C phage deoxyribonucleic acid (DNA) are described. Cells from log-phase cultures are the most susceptible to phage DNA infection (transfection). A cellular component (competence factor) which enhances transfection is released into the culture medium during the transition period between the log and stationary phase of growth. Transfection is stimulated in the order of decreasing effectiveness, by Fe(3+), Mn(2+), and Mg(2+). The efficiency of transfection is the highest in cells growing at 60.5 C and does not occur in cells growing at 67 C although the cells are growing normally. A cellular component (competence factor) of this organism, which is released into the culture medium, advances by 40 min some step in the uptake of phage DNA.


Modification of the composition and structure of the yeast cell wall by culture in the presence of sulfur amino acids. Growth of Candida utilis and Saccharomyces cerevisiae in a medium supplemented with sulfur amino acids led to synthesis and accumulation of S-adenosylmethionine, accompanied by a reduction in the cell yield, an increased sensitivity of the cell wall to snail gut enzymes (Helix pomatia), as judged by spheroplast formation, and by a modification of the chemical composition of both the intact cells and their isolated walls. Walls of supplemented cultures of C. utilis were three times as sensitive to enzymatic digestion as walls from nonsupplemented cultures. In contrast to C. utilis, walls isolated from supplemented cultures of S. cerevisiae were digested slightly more rapidly by the purified snail extract than those from nonsupplemented cultures. Chemical modifications of the cell wall are interpreted to explain the ease with which cells from sulfur amino acid-supplemented cultures are converted to spheroplasts.


Effect of serine hydroxamate on the growth of Escherichia coli. The structural analogue of l-serine, l-serine hydroxamate, inhibited the growth of Escherichia coli K-12. Of the other amino acid hydroxamates tested, only l-lysine hydroxamate reduced the rate of growth. Inhibition of growth by l-serine hydroxamate was rapidly reversed by the addition of l-serine to the bacterial culture or by removal of the analogue by filtration. The reversal of inhibition was specific for l-serine. l-Alanine, glycine, or adenine had no effect on an inhibited culture. No evidence for active transport of the analogue was obtained.


Flexor-tendon reconstruction in severely damaged hands. A two-stage procedure using a silicone-dacron reinforced gliding prosthesis prior to tendon grafting.


Biochemical bases for the antimetabolite action of L-serine hydroxamate. The amino acid analogue l-serine hydroxamate, which is bacteriostatic for Escherichia coli, has been shown to inhibit protein synthesis. The antimetabolite is a competitive inhibitor of seryl-transfer ribonucleic acid (tRNA) synthetase with a K(i) value of 30 mum. Mutants resistant to l-serine hydroxamate have been selected, and three were shown to have seryl-tRNA synthetases with increased K(i) values. One mutant contains a 3-phosphoglycerate dehydrogenase which is insensitive to inhibition by l-serine.


Amputations of the leg for peripheral vascular insufficiency.


Cross-finger pedicle flaps in the hand.

Cross-finger pedicle flaps in the hand.


A technique of muscle-pedicle bone graft in hip arthrodesis. A report of its use in ten cases.


Soft-tissue spread of giant-cell tumor. A case report.


Case report: the use of a structured mother-child interaction and projective material in studying parent influence on child behavior problems.


Reproduction of superimposed forms from dot patterns in five diagnostic groups of children.


Evaluation of the automated fluorescent treponemal antibody test for syphilis.


Centriole migration during regeneration and normal development of olfactory epithelium.


Virulent mutants of bacteriophage p22.I. Isolation and genetic analysis. Mutants of phage P22 which form plaques on a P22 lysogen have been isolated. These virulent mutants have been classified into three groups. (i) VirA mutants arise spontaneously in wild-type stocks and form very small turbid plaques on a P22 lysogen. The single mutation responsible for VirA virulence maps near the mnt locus, one of the immunity regions of phage P22. (ii) VirB mutants do not arise spontaneously and have been isolated only from mutagenized P22 stocks. VirB mutants form small, clear plaques on a P22 lysogen. One of the VirB mutants, virB-3, was analyzed in detail. The virB-3 mutant is comprised of two mutations: K5, which maps within the c(2) gene, and Vx, which maps in the region between the c(2) and c(3) genes. Phages carrying either the K5 or Vx mutation are not virulent in themselves but mutate to VirB virulence at a frequency of 10(-5) to 10(-6). It is concluded that K5 and Vx are mutations at specific sites which together confer the ability to undergo phage development in the presence of repressor. (iii) VirC mutants are defined by a large clear plaque morphology when plated on a P22 lysogen. VirC mutants are comprised of the determinants of both VirA and VirB virulence.


Variation of 6-methylaminopurine content in bacteriophage P22 deoxyribonucleic acid as a function of host specificity. The 6-methylaminopurine (MAP) content of P22 deoxyribonucleic acid has been analyzed as a function of the host specificity it carries. A 40 to 50% reduction in MAP level occurs as a result of growth in host cells defective in the ability to confer LT specificity.


Historical steps in the development of human cytogenetics.


In vitro cultivation of cells from human epidermis.


Community oral-health in contemporary dentistry.


Linguistic deficiency and thinking: research with deaf subjects 1964-1969.


Diagnosis and treatment of venereal disease.


[Total autologous transplatation of the uterus in the female dog. Technical, clinical and anatomical study of 15 cases].


[Vascular microanastomosis using mechanical suture apparatus. Comparative study].


Surgical procedure to prevent gastroesophageal reflux.


A technic for cervical rib resection.

A technic for cervical rib resection.


Improved technics using the bowel stapling clamps in nineteen consecutive gastric resections.


Properties of ventrobasal thalamic neurones in cat following interruption of specific afferent pathways.


Improvement in stereotaxic accuracy through the use of special x-rays.


Trends in the treatment of burns. The influence of McIndoe.


The effect of antigen pretreatment on canine renal allograft survival.


Proximity of the nucleoside monophosphate and triphosphate binding sites on deoxyribonucleic acid polymerase.


Transfer ribonucleic acid methylase activity in the developing pig brain.


Aspects of chromosomal structure. I. Circular dichroism studies.


2'-O-Methyl polynucleotides as templates for cell-free amino acid incorporation.


The mechanism of delayed hypersensitivity derangements in reticulum cell lymphomata (reticulosarcomata).


Hunterian pilgrimage.

Hunterian pilgrimage.


A functional study of the hypothalamo-neurohypophyseal system of the rat, with the use of a newly developed method for localized administration of labelled precursor.


MDHA membership directory.

MDHA membership directory.


Isotope scanning and fibrinogen degradation products in deep vein thrombosis.


Metabolic response to surgery in relation to caloric, fluid and electrolyte intake.


Partners in teaching. Veteran's Administration Center, Wood, Wisconsin and Marquette University School of Dentistry.


Organ culture of fetal rat pancreas. IV. Effects of metabolic inhibitors on insulin release.


Vibratory syringomyelic condition.

Vibratory syringomyelic condition.


A simple method of blood exchange in mice and its application to immunology.


The role of the graft in the induction of tolerance by antilymphocyte serum and cellular antigen.


Thymus grafting in allogeneic radiation chimaeras.


Antibody formation by bone marrow cells in irradiated mice. I. Thymus-dependent and thymus-independent responses to sheep erythrocytes.


An in vitro reaction between lymphoid cells and target fibroblastic cells: a possible model for in vivo rejection of haemopoietic allografts.


The effect of single large dose hydrocortisone treatment on IgM and IgG antibody production, morphological distribution of antibody producing cells and immunological memory.


Cytotoxic action of antiserum and complement: quantification with a colony inhibition method.


The Endocrine Society 1971 Annual Awards.


Changes in adrenocortisol function of patients with gonadal dysgenesis after treatment with estrogen.


Stimulation of insulin release in the dog by a nonmetabollizable amino acid. Comparison with leucine and arginine.


The effect of surgical isolation of the hypothalamus upon reproductive function in the female guinea-pig.


Peyer's patches: an enriched source of precursors for IgA-producing immunocytes in the rabbit. The proliferative and differentiative potential of Peyer's patch, peripheral blood, and popliteal lymph node cells was assessed by allogeneic cell transfer followed by quantitation of donor immunocytes by immunofluorescence. It was found that Peyer's patches are a highly enriched source of cells which have the potential to proliferate and differentiate into IgA-producing immunocytes and that the Peyer's patch cells are far more efficient in seeding the gut of irradiated recipient rabbits with donor cells that give rise to immunoglobulin-producing cells than cells from peripheral blood or popliteal lymph nodes.


Contribution of bone marrow cells and lack of expression of thymocytes in genetic controls of immune responses for two immunopotent regions within poly-(Phe,Glu)-poly-Pro--poly-Lys in inbred mouse strains. Previous cellular studies on the genetic regulation of immunological responsiveness for two immunopotent regions within the branched chain synthetic polypeptide (Phe, G)-Pro--L demonstrated a direct correlation between the number of detectable immunocompetent splenic precursor cells and the response patterns of SJL, DBA/1, and F(1) mice (21). In order to establish the cellular origin(s) of the genetic defect, the present study first demonstrated that thymus and bone marrow cell cooperation was required for (Phe, G)- and Pro--L-specific immune responses. Secondly, limiting dilution experiments, in which several graded and limiting inocula of marrow cells were mixed with a non-limiting number of 10(8) thymocytes and injected into irradiated, syngeneic recipients, indicated that the low responsiveness of the SJL and DBA/1 strains to the (Phe, G) and Pro--L specificities, respectively, could be attributed to a reduced number of precursor cells found in bone marrow. About five times more marrow precursors were detected in SJL mice for Pro--L than for (Phe, G), whereas about five times as many precursor cells were estimated for (Phe, G) as for Pro--L in the DBA/1 strain. These differences are similar to those obtained using spleen cells from unimmunized SJL and DBA/1 donors (21), and indicate that these genetically determined variations in responsiveness can be accounted for by differences in the frequencies of monospecific populations of immunocompetent cells present in bone marrow. In contrast, limiting dilution transfers of thymocytes or thymus-derived cells with an excess of syngeneic marrow cells resulted in equally frequent (Phe, G) and Pro--L responses for both SJL ad DBA/1 strains. This finding in conjunction with the observation that the generation of (Phe, G)- and Pro--L-specific responses were associated in individual recipients injected with limiting inocula of thymocytes indicated that a single population of thymocytes was stimulated by (Phe,G)-Pro--L. Therefore, it is improbable that the thymic population of immunocompetent cells contributes to expression of these genetically controlled defects.


Genetic control of bone marrow graft rejection. I. Determinant-specific difference of reactivity in two pairs of inbred mouse strains. Transplantation of 5 x 10(5) DBA/2 (H-2(d)) bone marrow cells into irradiated B10 and 129-strain mice (both H-2(b)) resulted in graft failure in the first recipient strain and in graft take in the second. Transplantation of B10 (H-2(b)) cells into irradiated B10.BR and C3H mice (both H-2(k)) also resulted in failure in the congenic B10.BR recipients and take in the C3H mice. Resistance and susceptibility of B10 and 129-strain animals were specific for given H-2 alleles of donor cells. Transplantation of DBA/2 marrow into (B10 x 129)F(2) mice and of B10 marrow into (B10.BR x C3H)F(1) x C3H backcross mice revealed definite genetic control of the graft-rejection process, presumably at the level of alloantigen recognition. Resistance to allografts, or responder status, was conferred upon segregating mice by dominant alleles of two major independent autosomal loci. The effects of the loci were additive. Conversely, susceptibility to allografts, or nonresponder status, was due to the apparently recessive alleles of both loci. None of the genes was closely linked with the markers tf (tufted) and T (brachyury) of linkage group IX, A(w) (white-bellied agouti) of linkage group V, Sl (steel) of linkage group IV, and c(ch) (chinchilla) and p (pink eye, dilute) of linkage group I. There were suggestions, however, that the regulator genes of marrow graft rejection are either non-H-2 histocompatibility genes or other genetic factors closely linked with them.


Effects of left atrial pressure and myocardial contractility on left ventricular volumes.


Modification of the stainless steel crown for primary teeth.


The chemical estimation of catecholamines and their metabolites in body fluids and tissue extracts.


The distribution of 51Cr-labeled lymphocytes into antigen-stimulated mice. Lymphocyte trapping. The localization of syngeneic (51)Cr-labeled lymph node cells was investigated in CBA/J mice previously challenged with sheep erythrocytes, Salmonella H antigen, keyhole limpet hemocyanin, C57BL/6J skin, or rat skin. The effect of time, dose, and route of antigen administration on lymphocyte migration was studied in both primary and secondary responses. When the distribution pattern of lymphocytes was examined after 20-24 hr, it was found that increased localization of labeled cells occurred in spleen after intravenous or intraperitoneal antigen injection, and in draining lymph nodes after subcutaneous antigen injection or skin grafting. Increased localization (trapping) of lymphocytes was antigen dose dependent and could be demonstrated when 1-6 hr had elapsed between intravenous antigen administration, or when 24 hr had elapsed between subcutaneous antigen administration and intravenous cell infusion. Trapping was transient, lasting approximately 24 hr. Maximal trapping of lymphocytes in the draining nodes occurred 9 days after skin grafting in the first-set allograft response, and 3 days after grafting in the second-set allograft and first-set xenograft responses. The cell type trapped, the specificity and mechanism of action of the trap, and the role of lymphocyte trapping in the initiation of immune responses are discussed.


Assay of enzymes of catecholamine biosynthesis and metabolism.


Measurement of choline acetylase.

Measurement of choline acetylase.


The chemical determination of histamine.


Homology of double stranded RNA from rat liver cells with cellular genome.


An esthetic method of anterior space maintenance.


Prototrophic regulatory mutants of adenylosuccinate synthetase in yeast.


Diploma Program in Nursing Accredited by National League for Nursing, 1971-1972. School year: September 16, 1971--September 15, 1972.


How free is DNA?

How free is DNA?


Treatment of fractures of the middle third of the root.


Morphologic changes in the pancreatic islets of the Chinese hamster in spontaneous diabetes and some experimental conditions.


The thymus gland: experimental and clinical studies of its role in the development and expression of immune functions.


The metabolic influence of progestins.

The metabolic influence of progestins. Information concerning the general metabolic, or what might be termed the systemic, effects of progesterone and synthetic progestins is reviewed.  Included in the review, are sections on: 1) electrolyte metabolism, 2) protein metabolism, 3) growth hormone secretion, 4) carbohydrate metabolism, 5) fat metabolism, 6) respiratory effects, 7) the influence of synthetic progestins on  electrolyte metabolism, and 8) the effect of synthetic progestins on electrolyte metabolism, and 8) the effect of synthetic progestins on protein metabolism.  It appears that aldosterone and progesterone are the dominate endocrine factors regulating salt excretion during pregnancy.  As 1 of the sex hormones, progesterone has a distinct growth-promoting influence on selected tissues of the accessory sex apparatus.  Progesterone induces protein wasting which can be compensated for by the comsumption of added calories.  It appears that progesterone is partially responsible for maintaining the positive energy balance in pregnant women, the appetite stimulus arising from the catabolic process which it initiates.  Recent interest in the influence of progesterone and synthetic progestins on pituitary growth hormone secretion has come about both as a by-product of studies done on the effects of progestins on protein and carbohydrate metabolism and  because of the known effects of other sex steroids on the output of this hormone.  Progestins whether derived from testosterone or 17-alpha-hydroxyprogesterone when employed in the usual antiovulatory doses, and progesterone in amounts comparable to the levels achieved in the first half of pregnancy have no adverse effect  on carbohydrate metabolism in normal men or women.  However, in diabetics and perhaps in potential or prediabetics, 17-alpha-hydroxyprogesterone derivatives may cause slight deterioration in glucose tolerance.  Circumstantial evidence has provided much support for the idea that some relationship exists between sex hormones and serum lipid content.  A great number of synthetic and few natural derivatives of testosterone have ben evaluated with the purpose of developing a pharmacologically effective steroid with the full general protein anabolic activity of the male hormone but with  minimal androgenic or virilizing potential.


Coronary disease and carbohydrate and fat abnormalities.


Adrenocortical control of epinephrine synthesis in health and disease.


The problem oriented record as a basic tool in medical education, patient care and clinical research.


Assessment of the effect of long-term dipyridamole in angina pectoris by atrial pacing and physical exercise.


A follow-up study of bacteriuria in female patients treated for recurrent urinary tract infections using dip-slides.


Acetyl CoA carboxylase. 3. Purification and properties of a biotin carboxyl carrier protein.


Purification and functional roles of the P I  and P II  components of Escherichia coli glutamine synthetase deadenylylation system.


Granny's herbs and the third crusade.

Granny's herbs and the third crusade.


Studies on the mechanism of fatty acid synthesis. XXVI. Purification and properties of malonyl-coenzyme A--acyl carrier protein transacylase of Escherichia coli.


Mutants of Escherichia coli K-12 which synthesize the pyruvate dehydrogenase complex constitutively.


Anesthesia and analgesia--50 years of publication.


Clinical study of droperidol in the prevention of the side-effects of ketamine anesthesia: a progress report.


Treatment of intractable coccygodynia by transsacral ammonium chloride injection.


Cerebral blood flow in hypoxemic anesthetized dogs.


Properties of the pyruvate formate-lyase reaction.


Review of the toxicity of hexachlorophene.


A field guide to cleft-lip repair.

A field guide to cleft-lip repair.


Technique of orthotopic liver transplantation in the pig.


We salute Richard Henry Barrett, M.D.

We salute Richard Henry Barrett, M.D.


Glutaraldehyde as a bactericidal agent.

Glutaraldehyde as a bactericidal agent.


Streptokinase in recent myocardial infarction: a controlled multicentre trial. European working party. In this controlled multicentre trial treatment with either streptokinase or heparin was allocated at random to patients suffering from myocardial infarction of less than 24 hours' duration. Treatment with either drug was standardized and lasted for 24 hours. A total of 764 patients entered the trial; 34 patient charts were rejected (including all 28 charts from one centre) because of data failure. On retrospective analysis of the 730 remaining patients the two groups were found to have been comparable at the start.The total hospital mortality was 18.5% of 373 patients allotted to streptokinase treatment and 26.3% of 357 given herapin. The mortality after infusion (24 hours) was 10.6% of 340 patients treated with streptokinase and 17.8% of 320 given herapin (P=0.011). Reinfarction in hospital after the 24-hour period of infusion occurred significantly less often in patients treated with streptokinase (P=0.036). Bleeding from puncture sites and pyrexia occurred more frequently during streptokinase treatment.After exclusion of those patients whose diagnosis was unconfirmed on retrospective assessment, the total hospital mortality rate was 19.0% of 357 patients treated with streptokinase and 27.4% of 339 treated with heparin (P=0.011). These results indicate that in recent myocardial infarction streptokinase was superior to heparin in reducing mortality and reinfarction rate during an average period of six weeks in hospital.


Resistance of the breast-fed infant to gastroenteritis. From in-vitro studies of breast and cow's milk preparations, and of the faeces from breast-fed and bottle-fed infants, a number of factors seemed likely to influence the production and maintenance of a lactobacillary flora and low pH in the faeces of newborn infants. These were mainly attributable to the nature of the feed. It is suggested that responsible factors in breast milk include its high lactose, low protein, low phosphate content, together with its poor buffering capacity. Importance is also attached to the fact that breast milk seems to provide a fluid feed of small bulk and low residue, and that its use is unlikely to include periods of starvation. Cow's milk, on the other hand, which has a low lactose, high protein, high phosphate content, and a high buffering capacity, is a relatively bulky, high-residue feed. Feeding regimens which employ it are likely to include periods of starvation.


Ten-year experience with IPPB in the treatment of acute laryngotracheobronchitis.


Partial exclusion of genes of bacteriophage T2 with T4-glucosylated DNA in crosses with bacteriophage T4.


Base-change mutagenesis and prophage induction in strains of Escherichia coli with different DNA repair capacities.


Genetic analysis of the histidine operon in Escherichia coli K12.


Histidine-requiring mutants of Escherichia coli K12.


Determination of maximal oxygen uptake with unsteady-state measurements.


Regional differences in pleural and esophageal pressures in head-up and head-down positions.


Morphology of the carotid sinus in the dog.


Cardiac output: comparison of Stewart-Hamilton and gamma-function techniques.


1971-72 Macomb District Dental Society membership roster.


An overview of motion pictures in medical education.


Alteration of intestinal microflora following preoperative mechanical preparation of the colon.


Pepsin secretion, gastric motility and mucosal blood flow in the anaesthetized cat. 1. There is a weak relationship between pepsin output and gastric mucosal blood flow (MBF) during vagal stimulation. When compared with the strong relationship between H(+) output and MBF, this suggests little dependence of pepsin secretion on MBF.2. Gastric MBF per unit H(+) output was significantly greater during vagal stimulation, when H(+) secretion was accompanied by pepsin secretion, than during pentapeptide stimulation when no pepsin was secreted.3. Pepsin output was not reduced during splanchnic stimulation whereas MBF and acid output were, when blood pressure was kept constant.4. Splanchnic stimulation did not produce any pepsin secretion.5. Gastric motor responses to vagal stimulation and to I.A. injections of acetylcholine were equally reduced by splanchnic stimulation.


Effects of stimulation on synaptic vesicles in sympathetic ganglia, as shown by fixation n the presence of Mg2+.


The Purkinje shift in cat: extent of the mesopic range. 1. The mesopic range, defined for cats with fully dilated pupils, extends from -1.0 to +1.4 log cd/m(2). The technique employed involves measurement of the relative shift in threshold with adaptation level, between two wave-lengths respectively selective for cones and rods at threshold. The magnitude of this shift is compared with that predicted from the Dartnall nomogram for visual pigments 556 and 507 (the in situ cone and rod absorption maxima).2. The result is based on monochromatic increment threshold determinations for 149 on-centre or off-centre fibres, isolated in the optic tract posterior to the chiasma, under a variety of adaptation levels. All units included receive dual input - from 500 nm rods and from a single class of cones with maximum sensitivity at 556 nm. No units receive input from 450 nm cones; six units with input mediated purely by rods are excluded from the sample.


Binocular interaction fields of single units in the cat striate cortex. 1. Based on average response histograms to an optimal stimulus, binocular interaction field plots were obtained from twenty-five simple neurones in the striate cortex of the cat. Each binocularly activated cell has two interaction fields, one for each eye. The binocular interaction field for one eye plots the changes in the amplitude of the response from the other eye as the two receptive fields of the binocularly activated cell are moved across one another, first into and then out of alignment in the plane of the optimal stimulus (tangent screen).2. The binocular interaction field provides an important clue to the nature of the spatial organization of the excitatory and inhibitory regions of the monocular receptive field. The commonest type of receptive field organization has regions of inhibition (inhibitory side bands) to either side of the discharge centre in the direction at right angles to the optimal stimulus orientation. As well as inhibition, there are subliminal excitatory effects.3. Binocular interaction fields differ with the various cell types, i.e. cells that are discharged only from the one eye, cells binocularly discharged with very weak or absent monocular responses and cells showing binocularly opposite direction selectivity.4. Marked facilitation to an optimal stimulus occurs when the two receptive fields of a binocularly activated neurone are in accurate alignment. Facilitation switches to depression for very small degrees of receptive field misalignment in a direction at right angles to the optimal stimulus orientation. These observations are of importance in relation to mechanisms for binocular single vision and depth discrimination.


E.G. Boring and the Zeitgeist: eruditione gesta beavit.


Induction of antiviral resistance and interferon production in animal cell culture by exogenous RNA.


Effect of immunity on interferon production.


Absence of pemphigus-type autoantibodies despite the presence of pemphigus-like histopathology: report of two cases.


Modeling: an alternative behavior modification approach for retardates.


1971 membership directory Greater Kansas City Dental Society.


Selection of recipients for kidney transplantation and their management.


Anesthetic problems in uremic patients.

Anesthetic problems in uremic patients.


Surgical technique of kidney transplantation.


Medical complications of renal transplantation.


Surgical problems of kidney transplantation.


Results of kidney transplantation in Poland.


Production of antilymphocyte serum for use in dogs and test of its immunosuppressive potency.


The demistification of implantology.

The demistification of implantology.


Selection of kidney donors.

Selection of kidney donors.


Preparation of cadaveric kidney for transplantation.


Experimental kidney transplantation.

Experimental kidney transplantation.


Preservation of dog kidneys under condition of hyperbaric oxygenation.


Heart transplantation in man.

Heart transplantation in man.


Analysis of hospital admission rates of patients with syphilis of the central nervous system in Poland before and after World War II.


Defeat in 1870: a melancholic marshal in Metz.


Steroid arthropathy.

Steroid arthropathy.


George Eliot's Dr Lydgate.

George Eliot's Dr Lydgate.


George Eliot and physiology.

George Eliot and physiology.


Physiological control of gastric acid secretion.


Reconstruction in head and neck surgery.


Repair of the laryngo-pharynx and cervical oesophagus after irradiation.


The Aural Department of St Bartholomew's Hospital.


Transmissible degenerative diseases of the nervous system.


Current thoughts on the replication of DNA.


Recent studies concerning the coding mechanism.


Uptake of nonviral nucleic acids by mammalian cells.


On the recognition of tRNA by its aminoacyl-tRNA ligase.


Application of the indirect fluorescent antibody test in experimental East Coast fever (Theileria parva infection of cattle).


A Salmonella carrier state of sheep following intranasal inoculation.


The pathophysiology of ovine ostertagiasis: water balance and turnover studies.


Peripheral blood leucocyte changes during human renal allograft rejection.


Cellular immunity of mice to skin allografts assessed by direct and indirect macrophage inhibition reactions in vitro.


Comparison of methods of 24-hr preservation of dog kidneys using the same perfusate.


Cardiac transplantation in mice. I. Factors influencing the take and survival of heterotopic grafts.


Cardiac transplantation in mice. II. Effect of continuous immunosuppressive therapy on the survival of H-2-incompatible allografts.


Some aspects of immunological tolerance investigateed by parent to F1 hybrid parabiosis in mice.


Eighth report of the Human Kidney Transplant Registry.


The accuracy of the mixed leukocyte reaction for predicting skin graft survival in inbred rabbits.


Prolongation of skin xenograft survival by L-asparaginase.


Isolation of cells infiltrating the skin allograft in mice.


Members of the Virginia Dental Association (as of June 1, 1971).


Vaginal infection. I. Microbiological findings.


The unpublished autobiography of James McKeen Cattell.


Prolegomenon to the study of apparatus in early psychological laboratories circa 1875-1915.


Rheumatoid arthritis associated with eosinophilia.


Vitamin B 12 -binding proteins of man.

Vitamin B 12 -binding proteins of man.


Goodpasture's syndrome: recovery from severe pulmonary hemorrhage after bilateral nephrectomy.


Alexander Gutman and the American Journal of Medicine.


Cancer in the immunosuppressed patient.

Cancer in the immunosuppressed patient.


Methylation of mercury compounds by  methylcobalamin.


-irradiation of thymine dimers in aqueous solution. Thymine dimers were irradiated in aqueous solution with (60)Co gamma-rays in N(2) or O(2). Thymine and unidentified non-UV-absorbing products appeared. The thymine was identified by spectrophotometry, chromatography, and ability to support the growth of Escherichia coli 15 T(-). Residual dimer was determined by a UV-reversibility assay. The G-values for dimer breakage were approximately equal in N(2) and O(2). At low gamma-doses, about two thymines were produced per dimer broken in N(2), whereas only about one thymine appeared per dimer broken in O(2). For dimer irradiated in frozen solution, the yield of thymine was at least 100 times less than in liquid.


Right heart, pulmonary, and left heart blood volumes determined by analogue computer analysis of radiocardiograms in normal subjects and patients with mitral stenosis.


Analogue model for the analysis of radiocardiograms.


Immunofluorescence studies in recent myocardial infarction.


Combined bite and impression technique.

Combined bite and impression technique.


Sensory examinations using electrically induced somatosensory potentials.


An enquiry into the effect of a spina bifida child upon family life.


Spina bifida--and the parents.

Spina bifida--and the parents.


[Heterogenous sensimelanoma].

[Heterogenous sensimelanoma].


Identification of the altered bases in mutated single-stranded DNA. IV. Nitrous acid induction of the transitions guanine to adenine and thymine to cytosine.


5-fluorouracil rescue of dCMP hydroxymethylase in Escherichia coli B infected by mutant am N122 of bacteriophage T4.


Alistair Livingston Gunn.

Alistair Livingston Gunn.


Regulatory mutants of the tryptophan operon of Salmonella typhimurium.


Dual control of arabinose genes on transducing phage lambda-dara.


Sequential biosynthesis of the   and  ' subunits of the DNA-dependent RNA polymerase from Escherichia coli.


Symmetric multifork chromosome replication in fast-growing Escherichia coli.


Quaternary structure of glutamate decarboxylase of Escherichia coli as revealed by electron microscopy.


Recessive-lethal nonsense suppressors in Salmonella typhimurium.


Record linkage. Its methodology and application in medical data processing.


In memoriam.

In memoriam.


Clinical evaluation of kidney function--tubular function.


Alpha 1 -antitrypsin and pepsin inhibition.


Rest and rheumatism.

Rest and rheumatism.


Chemotherapy and lung cancer.

Chemotherapy and lung cancer.


John Maxwell Clarke.

John Maxwell Clarke.


Thomas Jenkins.

Thomas Jenkins.


Maimonides.

Maimonides.


Vaginoplasty following vesicovaginal fistula repair: a preliminary report.


Alexander Voortman, M.B., Ch.B. (Cape Town).


Maurice Alexander Robertson, M.R.C.S. (Eng.) L.R.C.P. (Lond.) F.R.C.S. (Een.).


In vitro studies on contact-induced cytotoxicity in mice.


From caries to dentures.

From caries to dentures.


The mixed lymphocyte reaction. Detection of single histocompatibility loci and the correlation to skin graft survival in mice.


The effect of cytotoxic drugs on graft-versus-host disease in mice.


Immunochemical analysis of corneal antigens in xenogenic keratoplasty.


Pre-prosthetic surgery. 1.

Pre-prosthetic surgery. 1.


Indiana Academy of Ophthalmology and Otolaryngology.


A gene governing the female immune response to the male antigen in mice.


Pre-prosthetic surgery. 2.

Pre-prosthetic surgery. 2.


Studies on antilymphocyte serum and transplantation immunity in Syrian hamsters.


Unresponsiveness of nude mice to skin allografts.


Prevention of graft-versus-host reaction by donor pretreatment with soluble H-2 antigens.


Thermography in detection of human renal transplant rejection.


Allelic forms of a gene controlling the female immune response to the male antigen in mice.


Survival of a patient transplanted with a kidney infected with Cryptococcus neoformans.


Reflections on post-parturient diseases associated with lactational failure in sows.


In memoriam. Robert J. Masters, M.D. Indianapolis, Indiana.


Micturition urethrocystography in children with myelomeningocele. A radiologic and clinical investigation.


The role of the phagocyte in host-parasite interactions. XXXI. Serum and cellular iodine levels and their relationship to the hyperbactericidal activity of pregnancy.


Influence of the 30S ribosomal subunit on the peptidyl transferase activity of the 50S ribosomal subunit from Escherichia coli.


A kidney from the family.

A kidney from the family.


Pulmonary tuberculosis due to B.C.G.

Pulmonary tuberculosis due to B.C.G.


Comparative double-blind trial of cephalexin and ampicillin in treatment of urinary infections. Cephalexin was compared with ampicillin in the treatment of urinary tract infections by a random double-blind technique. Both drugs were found to be equally effective. In 21 out of 31 patients treated with cephalexin and in 20 out of 31 treated with ampicillin the urine was sterile three weeks after starting therapy. The bacteriological findings at one and eight weeks were also similar in both groups. No serious adverse reactions were attributable to cephalexin, which seemed to be tolerated rather better than ampicillin.


Psoriasis--clinical features.

Psoriasis--clinical features.


Haemodialysis--transplantation programme.


Long-acting phenothiazines in schizophrenia.


Corneo-scleral suture.

Corneo-scleral suture.


Research into psoriasis--the last decade.


Temperature-sensitive mutation. V. Infection of ts-mutant of RNA phage R17 and host cell metabolism.


The sulfhydryl groups of muscle phosphorylase. V. The reactive sulfhydryl peptides.


Similar effects by valine and isoleucine on threonine deaminase.


Emergency services. Psychiatric emergencies in the general hospital. A review.


Genetic and accumulation studies in sulfite-requiring mutants of Aspergillus nidulans.


George Brock Chisholm, 1896-1971.

George Brock Chisholm, 1896-1971.


The Winnipeg psychopathic hospital 1919-1969. An experiment in community psychiatry.


The mechanism of immunological unresponsiveness to picryl chloride and the possible role of antibody mediated depression.


Immunofluorescent studies on human spermatozoa. II. Characterization of spermatozoal antigens and their occurrence in spermatozoa from the male partners of infertile couples.


Independence of the nephritogenicity of group A streptococci from their M types.


Potassium and sodium distribution in cardiac failure.


Dilemmas in the treatment of Hodgkin's disease.


Lack of pineal-induced gonadal regression in dark-exposed or blind hamsters after surgical isolation of the medial-basal hypothalamus.


Ultrastructural search for homologues of pancreatic  -cells in the intestinal mucosa of the mollusc Buccinum undatum.


In 'defence' of the gastric mucosa.

In 'defence' of the gastric mucosa.


Genetics and gastroenterology.

Genetics and gastroenterology.


Conquest of deficiency disease.

Conquest of deficiency disease.


Historian of the college.

Historian of the college.


Clofibrate and dextrothyroxine in coronary heart diseases. A clinical and biochemical study.


Treatment of articular and non-articular (rheumatic diseases by indomethacin suppositories).


The Harris revision of the Goodenough draw-a-man test: suitability for a retarded population.


Changes in food and water intake associated with an interruption of the anterior or posterior fiber connections of the hypothalamus.


Karyotypic and surface features of murine TA3 carcinoma cells during immunoselection in mice and rats.


Changes in lymphoreticular tissues during growth of a murine adenocarcinoma. 3. Plaque-forming cell response in lymph nodes and spleen.


Alteration of skin in gross leukemia. II. Kinetic, preleukemic, and irradiation studies.


Pathogenesis of cutaneous Marek's disease in chickens.


Application of an indirect paired radio-iodine-labeled antibody technique to adenovirus-12 tumor serology.


Cancer research by the Atomic Bomb Casualty Commission.


The effects of gamma-radiation and heat on the germination of spores of Clostridium botulinum type E.


A descriptive analysis of the seven-year psychological data.


Comparative effects of enterotoxins from Escherichia coli and Vibrio cholerae on rabbit and swine small intestine.


Ultrastructure and insulin content of the endocrine pancreas in the human fetus.


Pathophysiologic changes induced in arteriosclerotic and nonarteriosclerotic rats by methylandrostenediol.


The classification of melanoma.fusion in dogs.


The development of the medical school at the University of Sydney.


Cadaver-donor renal transplantation. Treatment of end-stage renal failure by dialysis.


Acquired diseases of the aorta and its branches.


Investigations on the consumption of sugar by South African populations.


Significance of delayed or prolonged opacification of the renal arterial system.


In memoriam. Naurice Eugene Wolf, M.D., 1895-1970.


Light and electron microscope observations on the gastric mucosa of the frog (Rana esculenta). II. Structural alterations during hibernation.


Ulstructural localization of monoamines in the epidermis of Lumbricus terrestris (L.).


Distribution of monoamine oxidase in the hippocampal region of the guinea pig. I. Entorhinal area, parasubiculum, and presubiculum.


Light and electron microscope observations on the gastric mucosa of the frog (Rana esculenta). I. Normal structure.


Regulation of uterine contractility.

Regulation of uterine contractility.


Dr. Salzmann honored by the American Association of Orthodontists.


Allergy to hymenoptera stings--review of the world literature: 1953-1970.


The President, The American College of Physicians.


Production of L-asparaginase isoenzymes by strains E. coli.


Optical properties of membrane models at arbitrary angles of incidence.


Sweet mystery of life.

Sweet mystery of life.


Some teachers of biology at Guy's Hospital and its Medical School.


Prophylaxis of ventricular dysrhythmias following acute myocardial infarction: a double-blind trial of continuous intravenous infusion of lignocaine.


Nucleic-acid alkylation in relation to nitrosamine carcinogenesis and mutagenesis.


Immunofluorescent localization of calcitonin in the ultimobranchial gland of Rana temporaria and Rana pipiens.


Cancer chemotherapy today and tomorrow. (A review).


Giant follicular lymphoma. Clinico-pathologic review of 58 cases.


Toxic effect of polyriboinosinic-polyribocytidylic acid on mouse hemopoietic stem cells.


Spontaneous and adenovirus type 12-induced chromosome aberrations in Fanconi's anaemia fibroblasts.


Defects in hematopoietic differentiation in NZB and NZC mice. Hematopoietic stem cell activity in inbred NZB and NZC mice has been determined by transplantation and endogenous spleen colony assays. Whereas NZB mice show normal colony-forming unit (CFU) activity in the transplantation assay, they show markedly elevated endogenous CFU. NZC mice also show this markedly elevated endogenous CFU activity, but in the transplantation assay show only about 5-10% of normal CFU counts. When NZC stem cells are tested for CFU activity in irradiated recipients of the H-2(d) type, almost normal colony numbers occur. NZB stem cells however also cannot form colonies in NZC mice. These results suggest that NZC mice have a defect in the micro-environment of the spleen which renders them incapable of allowing transplanted CFU to form colonies. Genetic analysis of both the NZC defect as a CFU recipient, and the elevated endogenous count in NZB and NZC, shows that both are controlled by single recessive genes which are not linked to either coat color, agouti, H-2 or Ig loci. Of even more relevance is the finding that these hematopoietic abnormalities are not linked to the genes involved in controlling autoantibody formation to red cells in the NZB mice. These mice therefore appear to show two distinct hematopoietic abnormalities, the analysis of which may be of considerable value in understanding the detailed events of hematopoietic stem cell differentiation.


Toxic effects of streptococcal M protein on platelets and polymorphonuclear leukocytes in human blood. Purified M protein isolated from Group A streptococci produced cytotoxic reactions in normal human blood in vitro. In the presence of M antigen, platelets aggregated, fused, and lysed. Polymorphonuclear leukocytes (PMN) surrounded the platelet aggregates, then became highly vacuolated and lysed. In addition, PMN progressively lost their capacity to phagocytose unrelated bacteria and to migrate in glass capillary pipettes. Platelet-PMN reactions were directly proportional to the type-specific precipitin reactivity of each M preparation and could be removed with homologous M antibody, only. Moreover, the reactivity of M protein was abolished by enzymatic digestion with trypsin, but not with lysozyme, strongly suggesting that cell-wall mucopeptide was not involved. Preliminary studies showed that platelet-PMN reactions require heat-stable and heat-labile serum factors, presumably antibody and complement. It is suggested that cytotoxic determinants are uncovered by the extraction and purification process and are intimately associated with the type-specific M determinant, possibly in a molecular complex.


Behavior of attenuated mycobacteria in organs of neonatal and adult mice. The consequences of Calmette-Guérin bacillus (BCG) vaccination were followed in newborn and adult mice. BCG failed to multiply in the organs of adult mice when administered peritoneally. In contrast, extensive multiplication of the vaccine occurred in both splenic and pulmonary tissue after its peritoneal administration to newborn mice. This absence of tuberculostasis occurred during the period when the animal's spleen, lung, and thymus were rapidly growing. Animals achieved similar levels of resistance to virulent respiratory challenge 10 wk after vaccination irrespective of whether the vaccine had been administered when the mice were newly born and BCG had multiplied in vivo or administered when the animals were fully grown and the BCG had remained in the dormant state. Although neonatal infection with BCG was severe, as shown by the large numbers of organisms recovered from the animals' tissues, the animals suffered no mortality or overt signs of disease. Neonatal vaccination did not significantly affect either the animal's growth rate or the gross development of its organs.


Studies on a radio-resistant coccus isolated from Bombay duck (Harpodon nehereus).


Receptors on immunocompetent cells. II. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding lymphocytes of normal guinea pigs. Nonimmunized guinea pigs possess rare lymphocytes which bind sufficient 2,4-dinitrophenyl-guinea pig albumin-(125)I (DNP-GPA) to their surface to be detected by short-term radioautography. The cells occur in the lymph nodes, spleen, peripheral blood, and bone marrow with a frequency of approximately 40/100,000 lymphocytes, but are absent from the thymus. The receptors of these cells are largely specific for the haptenic group (epsilon-DNP-L-lysine) as shown by inhibition of DNP-GPA-(125)I binding with epsilon-DNP-L-lysine and with DNP bovine serum albumin (DNP-BSA). Furthermore, these cells specifically adsorb to agarose beads to which either DNP-GPA, DNP-BSA, or DNP-keyhole limpet hemocyanin (KLH) has been covalently linked. This hapten specific depletion of DNP-GPA-(125)I antigen-binding cells (ABC) correlates with a similar diminution in the capacity of adsorbed populations to transfer primary responsiveness to DNP-KLH to irradiated syngeneic recipients. Fluoresceinated anti-immunoglobulin binds to the surface of some guinea pig lymphocytes, and all DNP-GPA-(125)I ABC, as shown by a double-label technique. The great majority of DNP-GPA ABC and human gamma-globulin ABC possess surface Ig molecules of the gamma(2) heavy chain class. Preincubation of cell suspensions with anti-gamma(2) antibody markedly diminishes the number of DNP-GPA-(125)I ABC which are detected, strongly suggesting that the receptors of these cells are immunoglobulin molecules, most of which possess gamma(2) heavy chains. The specificity characteristics of DNP-GPA-(125)I ABC are strikingly different from those of cells mediating a cellular immune response to DNP-GPA, indicating major differences in the specificity and nature of the receptors of these cell types.


The chequered career of Galen's doctrine on the pulmonary veins.


Dr. Archibald Cameron.

Dr. Archibald Cameron.


Immune responses in vitro. 3. Development of primary gamma-M, gamma-G, and gamma-A plaque-forming cell responses in mouse spleen cell cultures stimulated with heterologous erythrocytes. We have demonstrated for the first time that mouse spleen cells stimulated in vitro with heterologous erythrocytes developed immunoglobulin class-specific gammaM, gamma(1), gamma(2a+2b), and gammaA plaque-forming cell (PFC) responses. A modification of the hemolytic plaque technique, the addition of goat anti-mouse micro-chain antibody to the assay preparation, specifically prevented development of all gammaM PFC and enabled accurate and reproducible enumeration of immunoglobulin class-specific PFC after treatment with appropriate monospecific anti-globulins and complement. Culture conditions, with regard to medium, atmosphere, agitation, and spleen cell densities, were similar to those previously shown to support only gammaM PFC responses. Evaluation of the kinetics of appearance of PFC showed that gammaM PFC reached maximum numbers on days 4-5; the magnitude of this response was 3-10 times greater than gamma(1) gamma(2a+2b), or gammaA PFC which reached maximum numbers on days 5-6. Optimal erythrocyte antigen dose for gammaM PFC responses was 10(7)/culture, whereas a dose of 10(6) erythrocytes/culture consistently stimulated optimal gamma(1) gamma(2a+2b), or gammaA PFC responses. Investigations of the effects of anti-erythrocyte antibody on gammaM and gammaG PFC responses indicated that antibody suppressed these responses by neutralizing the effective antigenic stimulus at the macrophage-dependent phase of the response. At the same antibody concentration, gammaG PFC responses were more effectively suppressed than gammaM PFC responses. Further, gammaG responses could be almost completely suppressed by antibody as long as 48 hr after initiation of cultures, whereas gammaM PFC responses could only be completely suppressed during the first 24 hr. These results were discusssed in terms of the role of antigen in the stimulation gammaM and gammaG antibody.


The life and teaching of William Sharpey (1802-1880). 'Father of modern physiology' in Britain.


Leprosy, echinococcosis and amulets: a study of a medieval Danish inhumation.


The medical resources and practice of the crusader states in Syria and Palestine 1096-1193.


The impact of the epidemics of 1727-1730 in South West Worcestershire.


The virtues of the cortex in 1680: a letter from Charles Goodall to Mr. H.


An unrecorded William Allen caricature?

An unrecorded William Allen caricature?


Changes in the pattern of reversion of a proline-requiring mutant of Salmonella typhimurium.


Preparation of the mouth for crown & bridgework by endodontics & periodontal surgery.


Computer assisted evaluation of liver scans.


Bacterial mutants defective in plasmid formation: requirement for the lon + allele. Bacterial mutants defective in plasmid formation were selected for their inability to be transduced to chloramphenicol resistance by bacteriophage PlCM. The mutants isolated are indistinguishable from a lon mutant strain. Both the lon strain and the mutants isolated here show very poor lysogenization by P1 and very low transduction to Gal(+) by the plasmid formation of the lambdagal(8)-Nam7am53cI(857). The lon(+) gene function of the host bacteria is indispensable for plasmid formation, even though P1 and lambda(+) can grow normally on the lon strains and lambda(+) can be integrated normally in lon as well as in the lon(+) bacteria. Phage mutants that can persist as plasmids in lon strains were isolated from P1CM. The function of the lon(+) gene is discussed with regard to plasmid formation.


A translocation-associated ribosomal conformational change detected by hydrogen exchange and sedimentation velocity. Translocation in ribosomes consists of transposition of peptidyl-tRNA from the aminoacyl to the peptidyl site and, probably concomitantly, the movement of ribosomes on mRNA. Does a conformational change in the ribosome provide the motive force for this process? Hydrogen exchange and sedimentation velocity experiments indicate that the Escherichia coli ribosome does undergo a conformational change associated with translocation. When pretranslocational ribosomes carrying acetyldiphenylalanyl-tRNA in the aminoacyl site were incubated with G factor and GTP, translocation occurred, with a concomitant increase in hydrogen exchange rate and a decrease in sedimentation constant. These changes did not occur when GTP was replaced by a nonhydrolyzable analogue, GDP-CH(2)-P, and they were blocked by the antibiotics fusidic acid and thiostrepton. When posttranslocational ribosomes were cycled back to the pretranslocational state by T factor, GTP, and phenylalanyl-tRNA, the sedimentation constant reverted to the original value. Whether or not this conformation change drives translocation requires further study.


Valinomycin-induced uptake of potassium in membrane vesicles from Escherichia coli. Osmotically shocked Escherichia coli and membrane vesicle ghosts from E. coli cells have lost the ability to accumulate potassium by active transport. The addition of valinomycin to the membrane ghosts restores the capacity to accumulate radioactive (42)K and (86)Rb by a temperature- and energy-dependent process. Membrane vesicles prepared from mutants of E. coli altered in potassium transport show defects in the valinomycin-stimulated accumulation of (42)K that are related to the defects in the intact cells.


Nature and self-regulated synthesis of the repressor of the hut operons in Salmonella typhimurium. The enzymes mediating histidine utilization, coded by the hut genes, in Salmonella typhimurium are synthesized from two closely-linked operons. Results presented in this paper show that these operons are regulated by a single repressor protein. The hutC gene, coding for this repressor, is part of one of the operons. Since this same operon is sensitive to the repressor, the repressor apparently represses its own synthesis.


Acetyl CoA carboxylase: isolation and characterization of native biotin carboxyl carrier protein. A large form of biotin carboxyl carrier protein (BCCP(L)) has been isolated from extracts of Escherichia coli. It has a minimal molecular weight of 20,000, according to its behavior on sodium dodecylsulfate-polyacrylamide gel electrophoresis, and contains approximately 1 mol of biotin per 22,000 g of protein. BCCP(L) exhibits K(m) values, in the biotin carboxylase and transcarboxylase half-reactions of acetyl CoA carboxylase, of 2 x 10(-7) M and 4 x 10(-7) M, respectively; these values are 50-100 times lower than those obtained with smaller forms of BCCP previously isolated. Electrophoresis of crude extracts of E. coli indicates that the major biotin-containing protein migrates at the same rate as BCCP(L), which suggests that BCCP(L) is the native form of BCCP in E. coli.


Role of exonuclease and beta protein of phage lambda in genetic recombination. V. Recombination of lambda DNA in vitro. The sequential action of lambda exonuclease and polynucleotide ligase upon redundant joint molecules is sufficient to produce intact polynucleotide chains and heat-stable, biologically active molecules of lambda DNA, whereas the action of ligase alone is insufficient. These results (a) confirm the previously described mechanism of single-strand assimilation, including a subsidiary mechanism by which the further action of lambda exonuclease is arrested when a redundant strand is completely assimilated, and (b) represent a simulation of the steps in genetic recombination that follow the formation of biparental complexes (synapsis). lambda exonuclease is postulated to catalyze a concerted reaction that includes exposure of complementary sequences, formation of heteroduplex regions, and elimination of redundant branches.


The use of cyano-acrylates in the dental laboratory.


Prolonged survival of glutaraldehyde-treated skin homografts. Treatment of mouse skin homografts in vitro with glutaraldehyde prolonged their average survival time from 12.4 to 39.2 days, presumably because the reagent became covalently bound to the histocompatibility antigen sites (or in their close vicinity) and shielded them from the immune apparatus of the recipient. The attachment to skin of the inert polymer poly((L)-lysine) via this bifunctional reagent increased the average survival time to 52.9 days. The simplicity and versatility of this approach might make it possible to screen a large number of reagents that can bind covalently to tissue constituents under physiological conditions. It seems possible that a particular treatment leading to a new contact surface in the transplant might favor the acceptance of homografts as well as of heterografts.


The gold-porcelain interface: a comparison of studies undertaken, using the electron and scanning electron microscope. (II).


Replacement of the avulsed scalp. Case reports.


Evaporative water loss from burns, grafts and donor sites.


Chronic pancreatitis a review.

Chronic pancreatitis a review.


Chloroquine-resistant falciparum malaria among British service personnel in West Malaysia and Singapore.


Malaria and the tropical splenomegaly syndrome in New Guinea.


The role of urinary tryptophan metabolites in the etiology of bladder cancer.


Plaque size and virulence of attenuated Venezuelan equine encephalomyelitis virus after passage in various hosts.


The neurologic learning disability syndrome.


The need for gynaecological services during adolescence.


Congenital microtia. Reconstruction with a silicone rubber (silastic) prosthesis.


Advances in the study of venereal disease.


Oesophageal hiatus hernias.

Oesophageal hiatus hernias.


News from the aflatoxin front.

News from the aflatoxin front.


Current concepts on transferrin. Factors affecting serum transferrin including pregnancy and hormonal therapy.


The toast, ladies and gentlemen, is to alcohol.


Psychopathology in man and lower animals.


Skin homograft in prevention of habitual abortion: report of a case and review of the literature.


Neurosurgical treatment of Parkinson's disease.


Degenerative joint disease (osteoarthrosis): a review with special reference to the dog.


By uniting we stand.

By uniting we stand.


Physicians' prescribing habits. Effects of Medicare.


Present status of renal transplantation.


Role of rehabilitation in the management of multiple sclerosis.


Bladder disturbances in multiple sclerosis and their management.


Behavioral aspects of multiple sclerosis.


Lymphocytes and the immune response. I.

Lymphocytes and the immune response. I.


The classic reprint. Staphyloraphe, or palate-suture, successfully performed.


Block of cerebral actions of L-dopa with methyl receptor substances.


Mr. Lucas and the B. L. letter (Colley Lyon Lucas).


Techniques used to assess the efficacy of psychotropic drugs: a critical review.


Enzymatic modification of transfer RNA.

Enzymatic modification of transfer RNA. The molecular events leading to the synthesis of mature tRNA are only now becoming amenable to experimental study. In bacterial and mammalian cells tRNA genes are transcribed into precursor tRNA. These molecules, when isolated, contain additional nucleotides at both ends (20) of the mature tRNA and lack most modified nucleosides. Presumably, specific nucleases ("trimming" enzymes) cut the precursor to proper tRNA size. The C-C-A nucleotide sequence of the amino acid acceptor end common to all tRNA's does not seem to be coded by tRNA genes (30), and may be added to the trimmed molecules by the tRNA-CMP-AMP-pyrophosphorylase (71). Modifications at the polynucleotide level of the heterocyclic bases or the sugar residues give rise to the modified nucleosides in tRNA. Although newly available substrates have allowed the detection of more of the enzymes involved in these reactions, there is still no knowledge about the sequence of modification or trimming events leading to the synthesis of active tRNA. Progress in these studies may not be easy because enzyme preparations free of nucleases or other tRNA modifying enzymes are required. The role of the modified nucleosides in the biological functions of tRNA is still unknown. Possibly pseudouridine is required for ribosome mediated protein synthesis; some other modified nucleosides in tRNA are not required for this reaction, but may enhance its rate. What might be the role of the large variety of modified nucleosides in tRNA? One is tempted to speculate that such nucleosides are important in other cellular processes in which tRNA is thought to participate such as virus infection, cell differentiation, and hormone action (2, 3). Mutants in a number of tRNA-modifying enzymes are needed in order to extend our knowledge of their purpose and of tRNA involvement in other biological processes. But unless tRNA-modifying enzymes specific for a particular tRNA species exist, no simple selection procedure can be devised. Possibly some of the regulatory mutants of amino acid biosynthesis may prove to affect tRNA-modifying enzymes (72). Transfer RNA's are macromolecules well suited for the study of nucleic acid-protein interactions. The tRNA molecules are structurally very similar, and they interact with a large number of enzymes or protein factors (2, 3). Each aminoacyl-tRNA synthetase, for instance, very precisely recognizes a set of cognate isoacceptor tRNA's (2, 73). The availability of the tRNA- modifying enzymes adds another dimension to the problem of the nature of specific recognition of tRNA by proteins. There are some tRNA-modifying enzymes, such as the uracil-tRNA methylase, which may recognize all tRNA species, while others, such as the isopentenyl-tRNA transferase, probably recognize only a selected set of tRNA molecules, even with different amino acid accepting capacities. With well-characterized RNA precursor and tRNA molecules we can hope to delineate those features of primary, secondary, and tertiary structure involved in the specific interactions of tRNA with these enzymes.


Ribosome-catalyzed polyester formation.

Ribosome-catalyzed polyester formation. Deamination of phenylalanyl-transfer RNA with nitrous acid yields the alpha-hydroxyacyl analog, phenyllactyl-transfer RNA. When this is incubated in a protein-synthesizing system directed by polyuridylic acid, it yields an acid-precipitable, alkali-labile polyester of phenyllactic acid.


Enhancement of rat renal allografts with F(ab')2 fragment of donor-specific antikidney serum.


The early years of chest radiology in Britain.


An early 20th-century testicular transplant.


Psychiatry in Venezuela: a brief history.


The Medicinal Herb Garden of The College of Physicians.


Enormous organ-like growth of transplants of fetal digestive tract.


Eugene Lindsay Opie, MD. July 5,1873--March 12, 1971.


Streptococcal cell wall structure inducing hepatic granuloma.


Polymorphonuclear leukocyte count in immediate biopsy of cadaver kidney grafts. Its predictive value for graft survival.


Methylation of DNA in ultraviolet-irradiated bacteria.


Evidence for the requirement of methionyl tRNA modification for in vitro polypeptide initiation in Streptococcus faecium.


A simple assay for protein chain termination using natural peptidyl-tRNA.


The assessment of airflow obstruction. Role of measurements of airways resistance and of tests of forced expiration.


The functional significance of clinical signs in diffuse airway obstruction.


Peptide bond formation on the ribosome. Structural requirements for inhibition of protein synthesis and of release of peptides from peptidyl-tRNA on bacterial and mammalian ribosomes by aminoacyl and nucleotidyl analogues of puromycin.


Dissecting aneurysms of the aorta.

Dissecting aneurysms of the aorta.


Interference of lysed fibrin with coagulation: a quantifying approach using isotopic techniques.


The anaemia of chronic disorders.

The anaemia of chronic disorders.


Source and occurrence of environmental contaminants.


Embryotoxicity of chemical contaminants of foods.


Fluoride.

Fluoride.


Naturally occurring nitrate and nitrite in foods in relation to infant methaemoglobinaemia.


A backward glance at the study of postmortem anatomy. 2.


Asbestos: questions still unanswered.

Asbestos: questions still unanswered.


A comparative study of pulmonary and circulatory effects of extrathoracic assisted breathing and intermittent positive pressure breathing.


The prestige of a profession and a social consciousness.


Relation between coherence of electron beam and contrast of electron image of biological substance.


Congenital central fibroma of the mandible.


Biological considerations for a functional esthetic restoration of dysplastic and fractured anterior teeth in children.


The use of progestagens in the control of the canine oestrous cycle.


Endocrinology of the oestros cycle in the bitch.


Secondary mineralization of rat molar healthy dentin by means of calcium hydroxide: a fluorescence study.


A review of currently available topical fluoride agents.


The Pereyra procedure. A favorable report of 80 operations.


Frozen sections in cervical conization. A cytohistopathologic approach in the early diagnosis of carcinoma cervix.


Do you owe money on your new equipment?

Do you owe money on your new equipment?


Physiological ketosis, or why ketone bodies?


Ectopic eruption of lower lateral incisors.


A critical appraisal of mechanisms concerned in non-ketotic hyperosmolar diabetic coma.


Diabetic comas.

Diabetic comas.


Obesity and diabetes; a review.

Obesity and diabetes; a review.


Doctoral education for nurses in the United States.


Nurses with earned doctoral degrees. An analysis of information collected for the American Nurses' Foundation Directory of Nurses with Earned Doctoral Degrees.


Viral hepatitis in drug addicts.

Viral hepatitis in drug addicts.


An analysis of various fluoride prophylaxis products for free fluoride ion concentrations.


The management of acute hepatic failure.


Development of an experimental model for functional cardiac replacement.


Simultaneous use of three indicators to evaluation pulmonary capillary damage in man.


A note on the word "veterinary".

A note on the word "veterinary".


The treatment of wounds of the lower parts of horses' limbs.


Observations suggesting the development of streptococci from pleomorphic filamentous gram negative bacteria.


Comparative in-vitro release of ferrous sulphate, aspirin and phenobarbitone from some waxy matrices.


The course and termination of neocortical, commisural fibres in the occipital cortex of the cat brain.


Findings in bones following dialyses and kidney transplantation.


Light and electron microscopic studies of the marginal sinus (v. Szily) in the developing human eye.


Effect of glucose on hypothalamic feeding centers in deafferented animals.


Occupational therapy--a historical perspective. Legacy of moral treatment--1800's to 1910.


Involvement in the rehabilitation movement--1942-1960.


The induction of alkaline phosphatase by extraskeletal implants of bone matrix.


Effect of osmotic pressure of the medium on the volume of intact cells of Azotobacter vinelandii and on the rate of respiration.


Loss of a normal colonic membrane antigen in human cancers of the colon.


The development of occupational therapy 1910-1929.


Antitumor and antimitogenic properties of cis-dichloro(dipyridine)platinum(II).


The depression years--1929-1941.

The depression years--1929-1941.


Rapid detection of mutagens and carcinogens.


The modern era--1960 to 1970.

The modern era--1960 to 1970.


The influence of age on chronic remittent Friend disease.


The subunit structure of the Escherichia coli K-12 pyruvate dehydrogenase complex. The dihydrolipoamide transacetylase component.


Immunochemical studies on Citrobacter O antigens (lipopolysaccharides).


Ribosomal proteins. Protein compositions of biosynthetic precursors and artifical subparticles from ribosomal subunits in Escherichia coli K 12.


The modernization of occupational therapy.


Modification of methionyl-tRNA synthetase by proteolytic cleavage and properties of the trypsin-modified enzyme.


Ameloblastoma of the maxilla: report of case.


The use of chemotherapeutic agents in the treatment of non-neoplastic diseases.


From whence to whither. Some reflections on surgical specialty training.


Rising sickness absence in Great Britain--a general practitioner's view.


Successful 20 hour preservation of ischemic canine lung by hypothermia combined with minimal ventilation.


Histologic changes associated with rejection of canine lung transplants.


Pulmonary hemodynamics following lung autotransplantation. Studies in unanesthetized dogs with the opposite pulmonary artery ligated.


Hemodynamic studies in two long-term survivors of heart transplantation.


Medical polemic of 1651. Physician contra surgeons and apothecaries.


Going beyond John Locke? Influencing American population growth.


Positive transpulmonary airway pressure.


The critically ill child: acute renal failure.


Continuous positive transpulmonary pressure in hyaline membrane disease: a simple device.


Accidental methadone intoxication in a child.


The American Board of Pediatrics.

The American Board of Pediatrics.


A difference between stem cells from marrow and spleen in initiating splenic megakaryocytopoiesis.


The quantitation of isotope loss with tyrosine loss in the canine fibrinogen-fibrin transformation.


Early histamine release and death due to endotoxin.


Comparison of autologous marrow injection to shielding in lethal irradiation of the mouse.


Cis-dichlorodiammineplatinum [II]: inhibition of nucleic acid synthesis in lymphocytes stimulated with phytohemagglutinin.


Measles antibodies in the cerebrospinal fluid of patients with multiple sclerosis.


Cellular stability in experimental hemorrhagic shock.


Alcoholism and pancreatitis.

Alcoholism and pancreatitis.


Comparison of histamine and pentagastrin in stimulation of pepsin secretion in man.


Wound infection prophylaxis with topical ampicillin (Pentrexyl R ) in gastric surgery.


Inactivation of human gastric pepsin by duodenal juice.


Gastric secretion in patients with carcinoma of the cardia.


The clinical significance of the fourth heart sound in aortic stenosis.


William Addison on blood vessels and inflammation (1841-43).


Aldo A. Luisada, MD, FACC: physician, scientist, teacher.


Team approach to the treatment of moribund asthmatic patients.


Lung function, pulmonary extravascular water volume and hemodynamics in early hemorrhagic shock in anesthetized dogs.


Ultrastructure of lung fixed under physiologically defined conditions.


L-asparaginase--clinical experience in leukaemia, lymphoma and carcinoma.


Furosemide in essential hypertension. A statistical analysis of three double-blind studies.


Evidence for intravenous dipyridamole (persantin) producing a "coronary steal" effect in the ischaemic myocardium.


Blockade of the reticulospinal inhibitory pathway by anaesthetic agents. 1. Adult cats were decerebrated at the intercollicular level. The effect of the anaesthetic agents, pentobarbitone, paraldehyde, tribromethanol, chloralose and procaine on the reticulospinal inhibitory pathway, which produced inhibition of segmental reflex potentials, was analysed.2. The doses which blocked this inhibitory pathway did not exceed the doses required to produce surgical level anaesthesia with any of the drugs.3. After the reticular inhibition of the reflex potentials was abolished, the reflex potentials were augmented by reticular stimulation with a higher intensity. This was thought to be due to spread of current to the excitatory pathways which were not completely depressed by the anaesthetic agent.4. The resistance of the reticular facilitation of the reflex potentials to inhibition by these drugs after abolition of inhibition corresponded in general to the degree of excitement in intact mice produced by the same drugs.5. These findings seem to indicate that the preferential block of the reticulospinal inhibitory pathway may be an important neural mechanism for the excitement stage of anaesthesia.


Investigations on glucose uptake in isolated human leucocytes from normal and diabetic subjects.


Citation for John Carl Villforth.

Citation for John Carl Villforth.


Immunologic properties of anti-lymphocyte sera.


The origin of antibody-producing cells in experimental synovitis.


Cellular events during the inducation of immune responses.


Kidney allograft in the pig by portal vein drainage.


Kinetic aspects of lymphocyte recirculation.


Surgeons as clinical pharmacologists.

Surgeons as clinical pharmacologists.