Influence of incubation temperature and sodium heptadecyl sulfate (Tergitol No. 7) on the isolation of salmonellae from pork sausage. Cultures of 68 samples of fresh pork sausage purchased locally were incubated at 37 and 43 C, with and without Tergitol No. 7 (sodium heptadecyl sulfate) added to the tetrathionate-Brilliant Green enrichment broth. The results indicated an advantage in incubating the tetrathionate broth at 43 C rather than 37 C in attempting to isolate salmonellae from pork sausage. Without Tergitol, more samples were positive at 43 C than at 37 C, but with Tergitol there was no difference. The higher temperature suppressed the competing gram-negative bacteria and permitted Salmonella to grow in relatively pure culture, thus providing an advantage for isolating and identifying the organisms. Tergitol dispersed and emulsified the fat which improved the isolation of Salmonella when the cultures were incubated at 37 C but not at 43 C. Brilliant Green-sulfadiazine agar was superior to bismuth sulfite agar for isolating salmonellae from tetrathionate broth cultures of fresh pork sausage.


Almond harvesting, processing, and microbial flora. This survey was set up on a statistical sampling plan to determine the microbial quality of almonds as they are received at the processing plant. The total aerobic bacterial count and yeast and mold count distribution were skewed by a few high counts compared with the majority of relatively low counts. Hard shell varieties of almonds had lower counts than did soft shell, and almonds with complete shells had lower counts than shelled almonds. Almonds harvested onto canvas had lower counts than those harvested by knocking onto the ground. Nuts with the least amounts of foreign material mixed into the sample had the lowest counts, as did nuts with the least amount of insect damage. Coliforms, Escherichia coli, and Streptococcus were isolated from the nuts, and their presence was correlated with soil contamination. When almonds are stored, the total plate count, the Streptococcus count, and the E. coli count after an initial drop remain nearly constant for more than 3 months. In addition to the indicator organisms, several genera of bacteria were isolated including Bacillus, Xanthomonas, Achromobacter, Pseudomonas, Micrococcus or Staphylococcus, and Brevibacterium.


Effects of a systemic antibiotic on nasal bacterial ecology in man. The nasal flora of coagulase-positive staphylococcus carriers and noncarriers was studied in aerobic conditions in 17 individuals. Five hundred milligrams of cephalexin was given orally four times daily for 12 days, and its effects on the nasal bacteria were determined quantitatively before, during, and after treatment. The total count obtained before the drug treatment was 5.4 x 10(6) in carriers and 3.9 x 10(6) in noncarriers. The lowest total count observed was 3 days after the cessation of the drug. The increase in gram-negative rods was seen 9 days after antibiotic therapy, not during the greatest reduction of gram-positive bacteria. Coagulase-positive cocci and diphtheroids were most sensitive to drug treatment. After 36 days, the total count was restored to pretreatment level. Diphtheroids did not return to the original number and were replaced by a corresponding increase of resistant coagulase-negative cocci. An inverse relationship between coagulase-negative cocci and lipophilic diphtheroids was seen in the anterior nares of many individuals. No gross difference in nasal ecology to differentiate carriers from noncarriers was seen.


Presumptive identification of group D streptococci: the bile-esculin test. Six tests commonly used for the presumptive identification of group D streptococci were evaluated. Strains tested included 282 group D streptococci and 366 non-group D. Ratios of percentages of group D to non-group D strains which gave positive reactions for each test are as follows: bile-esculin, 100:2; salt tolerance, 88:24; heat tolerance, 100:80; SF broth, 86:1; KF broth, 99:40; and methylene blue milk reduction, 90:17. These data indicate that the bile-esculin test provided a reliable means of identifying group D streptococci and differentiating them from non-group D streptococci. Methodology for reading and interpreting positive reactions and time of incubation of the bile-esculin medium was defined. Evidence of the need for standardization of salt and heat-tolerance tests was obtained.


Seasonal incidence of bacterial temperature types in Louisiana soil and water. Psychrophilic bacteria were not detected in soil, mud, and water in the summer. In winter, they were present in water and mud and constituted a significant portion of the bacterial flora in lake water.


Some properties of Escherichia coli adenyl cyclase.


Collagen from the giant acanthocephalan Macracanthorhynchus hirudinaceus.


Studies on the purification and properties of factor Tu from E. coli.


Studies on the role of factor Ts in aminoacyl-tRNA binding to ribosomes.


Inhibition of peptide chain initiation in Escherichia coli by hydroxylamine. Reaction of hydroxylamine with folate coenzymes.


Benactyzine metabolism in the rat.

Benactyzine metabolism in the rat.


Studies on the secondary structure of phenylalanyl transfer ribonucleic acid.


Relationship between peptidyl transferase activity and interaction of ribosomes with phenylalanyl transfer ribonucleic acid--guanosine 5'-triphosphate--TIu complex.


Specificities of alkaline and acid phosphatases in the dephosphorylation of phospholipids.


The use of a computer in the organization of a large-scale co-operative controlled clinical trial of the treatment of pulmonary tuberculosis. The organization of controlled clinical trials requires well-defined clerical procedures which, with large-scale studies, are so monotonous that it is difficult to attract and keep staff of a sufficiently high calibre. In a large-scale trial of pulmonary tuberculosis, a computer is being used to undertake much of the routine clerical work, including (1) the preparation of an appointments diary, which also specifies the exact requirements for the trial, and (2) the storage of all the data on magnetic tape so that periodic checks can be made for missing data and interim and final analyses can be produced rapidly. These arrangements reduce the time spent by clerical and statistical staff to a minimum. Although a strict evaluation of the effect of introducing the computer has not yet been made, this approach does appear to be sufficiently promising to warrant further investigations of a similar type.


The virulence of some strains of BCG for golden hamsters. Further studies. In principle, a strain of BCG used for the preparation of live vaccine should retain a moderate residual virulence. The inoculation of golden hamsters with large doses of BCG causes progressive, fatal disease but not all strains are equally active. In a previous paper, the present authors gave data from experiments with 9 BCG strains; in this report, 4 additional strains, three of which are in routine use in vaccine-production laboratories, are compared with one of the strains used in the previous experiments. The five strains differ widely in their ability to kill hamsters and were ranked in nearly the same order in two identically designed experiments. The differences in virulence found between strains derived relatively recently from a single mother strain were particularly noticeable. These differences were sometimes accompanied by striking changes in the growth characteristics of the strains with a lower virulence. The hypothesis that the lower virulence in such cases is a sign of genetic mutation is consistent with the general biological experience that virulence is often lost in vitro but that it practically never increases.


The protective effect in bank voles of some strains of BCG. The bank vole, like the guinea-pig, can be immunized against tuberculosis with very small doses of BCG, presumably because BCG is sufficiently virulent for both these species to multiply freely until the immunization of the animal has reached a maximum. Large doses of BCG induce an earlier, but not an ultimately stronger, immunity. However, the smallest immunizing dose is not the same for all BCG strains and this is a feature that may be used to differentiate strains. In the studies reported by the authors, the smallest immunizing dose for the bank vole was estimated for 11 BCG strains, some of them widely used in man. The results indicate potency ratios of 20: 1 between the strongest and the weakest strains. The ranking of strains in terms of the smallest immunizing dose was found to be correlated in most, but not in all, cases with a previously reported ranking of the lethal effects of the various strains in golden hamsters. The implications of these findings for production requirements and for reference preparations of BCG are discussed.


Carcinoid tumors.

Carcinoid tumors.


Discovery of the developmental cycle and transmission of toxoplasmosis.


Statement for the American Association of Ophthalmology. Before Committee on Ways & Means, House of Representatives.


Statement for ophthalmology. Before Committee on Ways & Means, House of Representatives.


Statement for the American Optometric Association. Before Committee on Ways & Means, House of Representatives.


Succinil estriol in bleeding due to adenoidectomy and tonsillectomy.


Delayed rejection of skin allografts in offspring of sensitized mothers.


Runt syndrome incidence and skin graft tolerance in various interstrain combinations of rats differing at a single or multiple histocompatibility loci.


The effect of antibodies present in the intestinal tract of germfree piglets on the infection caused by the intravenous administration of the pathogenic strain Escherichia coli 055.


Continuous cultivation of microorganisms. A review.


Francois J. Faucher, M.D. 1893-1970.

Francois J. Faucher, M.D. 1893-1970.


Robert A. Bearor M.D. 1922-1970.

Robert A. Bearor M.D. 1922-1970.


Clinical and immunological perspectives in food sensitivity. A review.


Compartmentalization of pseudorabies virus and subvirion components in BHK-21 cells and in the extracellular fluid. The intracellular and extracellular localization of pseudorabies virions and subvirion components was determined at various stages in the replicative cycle. It was discovered that infectious pseudorabies virus appears first in the nucleus of the infected cell early in the infectious cycle but later accumulates in the cytoplasm. Subvirion components (nucleoids and nucleocapsids) are restricted to the nucleus, and only the complete virion is released from the infected cell.


Process of infection with bacteriophage phiX174. XXXVI. Measurement of virus-specific proteins during a normal cycle of infection. Double-labeling techniques in which (14)C-labeled, phiX174-infected cells and (3)H-labeled, uninfected cells were used permitted the identification of the virus-specific proteins after separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis without prior inhibition of host-cell protein synthesis by ultraviolet irradiation. It was also possible to detect previously undescribed components of high molecular weight which may represent induced host proteins. The gel regions specifically corresponding to cistron II protein and the chloramphenicol-resistant VI protein were identified, and a third new, small peak of unknown origin was detected. Studies of the rate of synthesis of virus-specific proteins at various times after infection indicated that the product of cistron I (lysis) is made only late in infection, but the other proteins seemed to be synthesized at the same relative rates throughout infection (although in different amounts). Studies of the proteins obtained from uniformly labeled phiX virus particles indicated that all of the spikes are identical and allowed a formulation of the structure of the phage capsid.


Requirement for a functional int product in temperature inductions of prophage P22 ts mnt. Prophage P22 ts mnt was found to be inducible by high temperatures. This property was maintained when the ts mnt allele was recombined into a phage that cannot synthesize phage deoxyribonucleic acid at high temperature. Prophage P22 int ts mnt, on the other hand, was not inducible at high temperature. This result leads to the suggestion that the int enzyme, which is involved in excision, is regulated by the product of gene mnt.


Parent-to-progeny transfer and recombination of T4rII bacteriophage. Transfer of parental, light (not substituted with 5-bromodeoxyuridine) (32)P-deoxyribonucleic acid (DNA) from rII(-) mutants of T4 bacteriophage to heavy (5-bromodeoxyuridine-substituted) progeny in Escherichia coli B was less homogeneous than in wild phages. The net transfer was 5 to 20% of the value for wild T4 phage, and the parental contribution per progeny DNA molecule amounted to 7 to 100% of the genome. Three classes could be distinguished, based on the density distribution of parental label in CsCl analysis of the progeny phages. "Far recombined" phages contain parental material only in semiconservatively replicated subunits covalently attached to progeny DNA, amounting to 5 to 10% parental contribution per genome. "Intermediate recombinants" contain, aside from conventional recombinant DNA, parental DNA banding at the original, light density. This DNA may be unattached to heavy progeny DNA or attached by weak bonds which are very sensitive to shearing during the extraction procedure. The parental contribution is 10 to 50% per progeny DNA molecule in this class. "Conservative" phages band close to the parental, light density in CsCl; their DNA is purely light. When the parental phage is labeled with both (3)H-leucine (capsid) and (32)P (DNA), the specific activity of (3)H/(32)P in the "conservative progeny" is 10 to 40% of that in the parental, showing that at least some of the (32)P in this area belongs to phages with parental DNA as the sole DNA component inside an unlabeled capsid, i.e., parental DNA which has been injected into the host and matured in a new capsid without replication or recombination. This phenomenon occurs to about the same extent in both single and multiple infection.


Increased fragility of Escherichia coli after infection with bacteriophage M13. Male strains of Escherichia coli infected with filamentous phage M13 released the progeny phage particles from intact cells. At the same time, the cells continued to grow and multiply at a slightly lower rate than the uninfected cells. Concomitant with the phage release, lipopolysaccharide from the cell wall of the infected cells was also released. The buoyant density of E. coli HfrC in diaginol, 1.25 g/cc, did not change as a result of infection. Detergents like sodium dodecyl sulfate and Sarkosyl specifically lysed the infected cells. The infected cells showed enhanced fragility as indicated by inactivation by various stresses, namely heat, osmotic shock, and freezing and thawing. It is concluded that the infection with M13 causes certain alterations in the surface structure of E. coli, thus making the cells more fragile.


Conversion of T4 gene 46 mutant deoxyribonucleic acid into nonviable bacteriophage particles. The T4 amber mutant N130 in gene 46 produces, upon infection of a nonpermissive host, about 10 times more phage equivalent of deoxyribonucleic acid (DNA) than viable phage particles. Intracellular DNA is shorter than its mature phage counterpart and is converted into nonviable, light phage particles (287S) with about half of the normal DNA content, incapable either of adsorbing to or killing host bacteria. This DNA is highly unstable and breaks down, upon extraction, into subunits one-tenth the normal length of T4 DNA. Electron micrographs showed that the nonviable particles consist of normal-sized capsids of various degrees of fullness. Abnormal tail structures (naked cores with the sheaths missing) were also observed. Under conditions of arrested DNA synthesis, late messenger ribonucleic acid is produced, but some species are rare or missing, resulting in uneven transcription of the late genes. Our findings indicate that continuous DNA replication is necessary for normal transcription in T4.


What we learned from a double blind study of librium.


The effects of caffeine, ultraviolet and x-irradiation on DNA breakdown in E. coli B and some of its dark repair mutants.


Nonsense mutants of Serratia phage Kappa. I. Their isolation and use for proving circular linkage of the phage genes.


Mechanism of conjugation and recombination in bacteria. IX. The role of DNA synthesis in post-conjugal genetic recombination.


Location of genes controlling excision repair of UV damage and mutator activity in Escherichia coli WP2.


Replication of bacteriophages in Escherichia coli mutants thermosensitive in DNA synthesis.


The 1970 Presidential Address.

The 1970 Presidential Address.


Jessie Wright, M.D.

Jessie Wright, M.D.


Heart transplantation.

Heart transplantation.


Kidney transplantation.

Kidney transplantation.


Liver transplantation.

Liver transplantation.


Lung transplantation.

Lung transplantation.


Corneal grafting.

Corneal grafting.


The problem of rejection.

The problem of rejection.


Disodium cromoglycate with and without isoprenaline.


A double-blind sequential trial of salbutamol and isoprenaline aerosols in general practice.


The Montpellier school of medicine.

The Montpellier school of medicine.


Franklin Gessford Ebaugh, M.D.

Franklin Gessford Ebaugh, M.D.


Rickets.

Rickets.


Malignant neoplasms of the nasopharynx.

Malignant neoplasms of the nasopharynx.


G. Stanley Hall's conception of mental development and some indications of its influence on developmental psychology.


Relationships between the prevalence of gastrointestinal disease and environmental contamination on a pediatric ward.


We want excellent medical care for all.

We want excellent medical care for all.


Effect of caerulein on peptic secretion of the rat.


A new table for the estimation of particle density.


The effect of cyclandelate on mental function in patients with arteriosclerotic brain disease.


Ronyl (pemoline) in overactive mentally subnormal children.


'Mandrax' as an hypnotic for psychiatric in-patients: a comparative trial with chloral hydrate.


Lincoln and non-restraint.

Lincoln and non-restraint.


The Seebohm report.

The Seebohm report.


Comparative trial of a new mono-amine oxidase inhibitor in depression.


Pulsatile velocity of blood in the pulmonary artery of dogs: measurement by an ultrasound gauge.


Mutagenesis in Escherichia coli. 3. Requirement for DNA synthesis in mutation by gamma rays of T4-phage complexed with Escherichia coli.


Functional analysis of host-specificity mutants in Escherichia coli.


Hippocampal syndromes.

Hippocampal syndromes.


Temporomandibular joint arthroplasty: review of literature and report of case.


Evidence for a role of proteinpolysaccharides in regulation of mineral phase separation in calcifying cartilage. Our previous studies have indicated the presence of a macromolecular inhibitor of in vitro mineral growth, as well as a mineral nucleational agent in extracellular matrix fluid aspirated by micropuncture methods from epiphyseal hypertrophic cell cartilage. In this report, new miniaturized methods were used to extract proteinpolysaccharide complexes (PPC) from cartilage, to isolate a light fraction (PPL-C), and further, to separate it into R1, R2, and SR2 subfractions. These methods were applied to PPL-C complexes separated from microdissected epiphyseal cartilages and to cetylpyridinium chloride (CPC) precipitates of extracellular matrix fluid aspirated from similar cartilages. Most of all of the inhibitory action on an in vitro system of mineral growth shown by whole cartilage PPL-C and by cartilage fluid PPC obtained from noncalcifying sites was contained in the R2 fraction which represented (1/4)-[unk] of the total hexuronate. The R2 fraction was diminished or absent from calcified cartilage fluids and from whole calcified epiphyseal septa. The ratio R1 + R2: SR2 ranged from 0.37 to 0.71 in the fluids and whole tissue samples of noncalcified cartilages. The R2 fraction was distinguished from SR2 by a 2- to 3-fold higher protein: hexuronate ratio. These data are interpreted to indicate that the inhibitory R2 fraction was degraded or otherwise inactivated at the zone of provisional calcification and that this inhibitor participates in the physiological mechanism that regulates endochondral calcification.


The paralyzed larynx: an electromyographic study in dogs and humans.


Microscopic laryngoscopy. A review and appraisal.


Observations in the development of tracheal prostheses and tracheal transplantation.


Carcinoma on the horizontal ramus of the mandible.


Rehabilitation following anterior jaw resection.


Evaluation of preparative techniques for the scanning electron microscope.


Regulation of the lactose operon in vitro. I. Transcription of the lactose operon.


Chromosomal location of ribosomal RNA cistrons in Escherichia coli.


Two kinds of activity promoted by culture filtrates of male strains of E. coli K-12. Inhibition of "nitrogen mustard after-effect" and stimulation of genetic recombination.


Genetic studies on temperature sensitive nonsense suppression.


Thermosensitive regulation of D-serine deaminase synthesis in a mutant of Escherichia coli K 12.


Genetic studies of the ribosomal proteins in Escherichia coli. 3. Compositions of ribosomal proteins in various strains of Escherichia coli.


Genetic map of Escherichia coli strain C.


In vivo repair of UV-irradiation damage of single stranded DNA phage phi-X 174.


Different modes of loss of photoreversibility of ultraviolet light-induced true and suppressor mutations to tryptophan independence in an auxotrophic strain of Escherichia coli.


Repair systems and nitrous acid mutagenesis in E. coli B-r.


Should infants be allowed to drink tea?

Should infants be allowed to drink tea?


Treatment of chronic uremia in childhood. II. Hemodialysis.


Kidney transplantation in children.

Kidney transplantation in children.


The book of accidents. Excerpt V: Firearms.


The treatment of sarcoidosis.

The treatment of sarcoidosis.


Computer algorithms for the detection of brain scintigram abnormalities.


Computer assistance in the interpretation and quantification of lung scans.


In vivo radiation dosimetry. Review of a 12-year experience.


Improvements in the radiological image. A report from the Radiation Study Section of the National Institutes of Health.


Masters in medicine Pirogov and Garibaldi.


The mental implications of sex chromosome aberrations.


Human pituitary disease.

Human pituitary disease.


Response of asthmatics to isoprenaline and salbutamol aerosols administered by intermittent positive-pressure ventilation. The bronchodilator and cardiac effects produced by aerosols of 0.5% isoprenaline and of 0.25, 0.5, and 1% salbutamol administered in 40% oxygen by intermittent positive-pressure ventilation were compared in 24 asthmatic patients. Isoprenaline and salbutamol in concentrations of 0.5% were equipotent in peak bronchodilator effect; salbutamol was superior in total bronchodilator effect and duration of average effect, but the peak bronchodilator effect occurred earlier after isoprenaline. Significantly greater tachycardia was produced by 0.5% isoprenaline than by the same concentration of salbutamol. The 0.25, 0.5, and 1% concentrations of salbutamol had about the same peak bronchodilator effect, but there was a stepwise increase in total effect and duration of average effect in relation to the concentration used. A similar stepwise increase in heart rate was also noted, but with all concentrations this was significantly less than with 0.5% isoprenaline. It was concluded that a 0.5% solution of salbutamol, which provided maximal bronchodilatation without important tachycardia, was therapeutically superior to the other three treatments.


Endotoxin and acute renal failure associated with obstructive jaundice. A single dose of endotoxin given to rats with obstructive jaundice produced death with intravascular coagulation. This action was apparently due to delayed clearance of endotoxin from the circulation. The finding is relevant to "hepatorenal failure," which can be caused by bacteraemia after biliary tract operations.


Neuropathy, IgM paraproteinaemia, and autoantibodies in hypernephroma.


Evidence for antigenicity in human tumours with reference to both melanoma and acute leukaemia.


Correlation of the S100 brain protein with behavior.


Isoantigen expression in hybrid mouse cells.


Differential cytological and cytochemical responses of various cultures from mouse tissues to repeated exposres to puffs from the gas phase of charcoal-filtered fresh cigarette smoke.


Changes in deoxyribonucleoprotein during spermiogenesis in the bull. Sensitivity of DNA to heat denaturation.


Heteromorphic budding in lithium-treated sea urchin embryos. A study of gene expression.


The reactions between formaldehyde, glutaraldehyde and osmium tetroxide, and their fixation effects o bovine serum albumin and on tissue blocks.


The influence of formaldehyde fixation time on the rate of nitrous acid deamination of erythrocytes and spinal cord proteins.


Isolation of Escherichia coli transfer RNA-gene hybrids.


Correlations between host-cell reactivation, ultraviolet reactivation and pyrimidine dimer excision in the DNA of bacteriophage lambda.


Review of some nutritional aspects of the sense of taste.


Immunity phase-shift in defective lysogens: non-mutational hereditary change of early regulation of lambda prophage.


Ribonuclease V of Escherichia coli. IV. Exonucleolytic cleavage in the 5' to 3' direction with production of 5'-nucleotide monophosphates.


Isolation of mutants of Escherichia coli lac   king 5-methyluracil in transfer ribonucleic acid or 1-methylguanine in ribosomal RNA.


Osteogenic sarcoma of the mandible.

Osteogenic sarcoma of the mandible.


Droplet nuclei produced during dental treatment of tubercular patients. A preliminary study.


Controlled demineralization of bone specimens.


Augmentation bone graft for correction of mandibular asymmetry.


Systemic and coronary hemodynamic effects of perhexiline.


The pepsins from human gastric mucosal extracts. 1. The pepsins and pepsinogens of the gastric mucosal extracts of two normal subjects, of seven patients with gastric adenocarcinoma and of two patients with duodenal ulcer have been investigated by agar-gel electrophoresis and by ion-exchange chromatography. 2. Of the eight zones of proteolytic activity that have previously been reported in normal human gastric juice, seven can be detected in activated fundic mucosal extracts. Of these seven, four can be attributed to discrete pepsins, numbered 1, 3a, 3 and 5. 3. Zone 7 results from the activity of one or more enzymes that are alkali-stable and are best referred to as gastric proteinases rather than as pepsins. Zone 7 is much more evident in mucosal extracts than in gastric juice. 4. Zones 4 and 6 may result respectively from the activity of a pepsin-inhibitor complex and of an unactivated zymogen. 5. It was not possible, by the chromatographic methods employed, to separate satisfactorily the individual pepsins from activated extracts or their precursors from unactivated extracts, so that the ascribing of a pepsin to a specific zymogen must be considered tentative. Even so, pepsin 3 appears to arise from at least two major precursors, if not from three, whereas pepsins 1 and 5 each arise from a single major precursor. 6. Pyloric mucosal extracts contain principally zone 5 but also zones 6 and 7. These zones in general behave similarly to the corresponding zones of fundic extracts, but pyloric pepsin 5 migrates slightly faster on agar-gel electrophoresis than does fundic pepsin 5 and is a different enzyme. Zones 1 to 4 are absent.


Amino acid sequences around the disulphide bridges and methionine residues of porcine pepsin. 1. The amino acid sequences around three disulphide bridges and four methionine residues of porcine pepsin were studied by using diagonal electrophoresis methods. 2. Two of the three disulphide bridges were in small loops of five and six residues. The sequence around one of the two half-cystine residues of the third disulphide bridge had a large number of acidic residues. 3. The sequence of a tetrapeptide containing phosphoserine was also determined. 4. Four unique methionine-containing sequences were constructed. The information is sufficient for the determination of the overlaps in the cyanogen bromide fragments of pepsin. 5. The usefulness of diagonal methods in the study of protein structure, the relative positions of cystinyl and methionyl residues in porcine pepsin and the homology between pepsin and rennin are discussed.


On the determination of molecular weight of proteins and protein subunits in the presence of 6 M guanidine hydrochloride.


The action of streptomycin in a mutant of Escherichia coli with increased sensitivity to the antibiotic. A mutant of Escherichia coli with increased sensitivity to streptomycin has been studied. This strain differed from a normal str(s) strain in that streptomycin produced inhibition of protein synthesis and loss of viability with almost no lag period. Chloramphenicol protected a normal str(s) strain but not the mutant against the bactericidal action of streptomycin. The results obtained support the idea that access of streptomycin to its site of action in a normal cell is restricted, and that this restriction, which is much less effective in the mutant, probably involves a permeability barrier. Comparison of the inhibition of protein synthesis by streptomycin with concomitant changes in the distribution of polyribosomes in both strains suggested that the antibiotic can directly inhibit the translation of mRNA.


In vitro metabolism of testosterone-4-14C and delta-4-androstene-3,17-dione-4-14C in human skin.


Localization of sparsomycin action to the peptide-bond-forming step.


The specificity of transfer ribonucleic acid methylases from rat liver.


Anaerobiosis-induced changes in an isoleucyl transfer ribonucleic acid and the 50S ribosomes of Escherichia coli.


Hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone in treatment of hypertension. In an open, randomized, cross-over study the hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone combinations were compared. The diastolic morning blood pressure could be reduced to 95 mm. Hg or below in significantly more patients with clonidine than with methyldopa. Side effects, however, were more commonly encountered during the clonidine than during the methyldopa phase.


Maintenance haemodialysis and renal transplantation.


Immunosurveillance and cancer: epidemiological evidence.


Continuous ventilation and oedema.

Continuous ventilation and oedema.


Immunological features of choriocarcinoma.


Endometrial adenocarcinoma in a cat.

Endometrial adenocarcinoma in a cat.


Sir John Floyer (1649-1734) and the discovery of pulmonary emphysema.


Commentary. Closed designs for sequential clinical trials.


Feline viruses. X. Characterization of a newly-isolated picornavirus causing interstitial pneumonia and ulcerative stomatitis in the domestic cat.


External otitis:controlled therapeutic trial.


Ménière's autopsy report.

Ménière's autopsy report.


L-Dopa in the treatment of parkinsonism.


The use of nylon sutures in anterior segment surgery.


The analgesic effect of carbiphene hydrochloride.


The evaluation of an anesthetic mouthrinse on four hundred periodontal surgery patients.


Stilboestrol transport and glucoronide formation in everted sacs of rat intestine.


Clinical biostatistics. VI. Statistical "malpractice"--and the responsibility of a consultant.


Induction of labour using prostaglandins.


Prenatal genetic diagnosis. I.

Prenatal genetic diagnosis. I.


Hospital-acquired infections.

Hospital-acquired infections.


Streptomycin resistance and the study of ribosomal structure and function.


Droperidol injection (Inapsine).

Droperidol injection (Inapsine).


Trials of Ro 5-3350 and diazepam for anxiety symptoms.


Continuous positive-pressure ventilation in acute respiratory failure.


Revival of an old battle: intermittent vs. continuous positive-pressure breathing.


Transplantation of a kidney from a patient with idiopathic hypercalciuria.


Levodopa (Larodopa). For the relief of symptoms associated with Parkinson's disease and syndrome.


Topological and functional organization of the mitochondrion. The morphological and biochemical properties of isolated mitochondrial inner and outer membranes are summarized and discussed in relation to the functional organization of the intact mitochondrion. The enzymatic composition of the mitochondrial inner compartment is compared to over-all mitochondrial function. The role of the mitochondrial outer compartment is discussed with reference to both the inner membrane-matrix fraction and the intact mitochondrion.


Release of tRNA from ribosomes by a factor other than G factor. In addition to the G factor there exists another factor in the E. coli extracts which stimulates the release of tRNA from ribosomes. This factor is distinctly different from the G factor and may play a role in removing tRNA from the ribosome after the polypeptide chain termination factor has released the completed chain from the ribosome-bound tRNA.


Suppression of malignancy and differentiation in melanotic melanoma cells. Tumorigenicity of mouse melanoma cells is reduced or lost upon growth in vitro in 1 to 3 mug/ml of 5-bromodeoxyuridine (BUdR). The rate of growth is very little affected by these concentrations. The morphology of the cells is altered, such that the cells grow in a flattened, often fibroblastic monolayer, showing contact inhibition, instead of the rounded, multilayered mounds characteristic of the line. Melanotic cells lose their pigment-producing ability within one week. These effects are reversible and the inclusion of thymidine with BUdR prevents their occurrence. The reduction in tumorigenicity, the effects on cell morphology, and the suppression of pigmentation occur in clones derived from single cells growing in BUdR as well as in mass populations. These clones appear capable of indefinite growth in vitro in BUdR with altered morphology. The suppression of cytodifferentiation in these melanoma cells and in embryonic cells, coupled with the modification of malignancy, leads to the hypothesis that both differentiation and malignancy are regulated by similar cellular mechanisms. These effects of BUdR offer promise of a powerful tool to probe these regulatory mechanisms.


Tropical sprue and malnutrition in West Bengal. I. Intestinal microflora and absorption.


Jejunal bacterial flora in chronic small bowel disease. I. Celiac disease. II. Regional enteritis.


Gentamicin in the neonatal period.

Gentamicin in the neonatal period.


Hyposensitization therapy in treatment of allergic disease.


Sigurd Malmo G.R.V.C.

Sigurd Malmo G.R.V.C.


Nasal reconstruction by scalping flap in a case of malignant melanoma of the nasal tip.


Application of electrotherapy to noncardiac thoracic disorders.


Utilizing computers in evaluating health data.


Infibulation, population control, and the medical profession.


Proper urine culture techniques in infants and children.


Originator of the rubber dam. Sanford Christie Barnum, D.D.S.


A comparative study of alevaire and a new mucolytic agent, acumist in postoperative patients.


Lamelar keratoplasty. A review of 40 cases.


Method, design, and analysis of a comparative study of analgetics.


Comparative blood level study of different brands of chlordiazepoxide hydrochloride and their coadministration with chymotrypsin.


A comparative evaluation of intramuscular atropine, dicyclomine, and glycopyrrolate using healthy medical students as volunteer subjects.


Barbiturate anesthesia in dogs wearing collars containing dichlorvos.


A comparison of single layer suture patterns for intestinal anastomosis.


Time estimation and temporal orientation in delinquents and nondelinquents: a re-examination.


Interpreter bias on the Rorschach Test as a function of patients' socioeconomic status.


Initial notes on content in auditory projective testing.


Characteristics of House-Tree-Person drawings by college men and women.


Effects of model's and observer's hostility on Rorschach, interview and test performance.


Comment in "shading as an index of anxiety in figure drawings".


Pin implants: a method of stabilizing the full lower denture.


Johannes Müller (1801-1858), Anatomist, physiologist, pathologist.


Doctor and patient: the changing pattern.


The beginnings of medical care for Aborigines in Eastern Australia (N.S.W.).


Structure and activity of acetylcholine.


Short- and auto-feedback control of pituitary FSH secretion.


Storage of prolactin-inhibiting factor in the hypothalamus of perphenazine-treated rats.


Adverse effects on the fetus of acute events in labor.


Drugs that depress the newborn infant.

Drugs that depress the newborn infant.


Barbiturates and asphyxia.

Barbiturates and asphyxia.


Serious congenital heart disease in the newborn infant: diagnosis and management.


Oxygen dependence and repair of lethal effects of near ultraviolet and visible light.


Catheterization of umbilical vessels in newborn infants.


Studies on the mode of action of anti-lymphocyte globulin.


A field trial with an oral vaccine against enteritis.


Laboratory control of oral Shigella sonnei vaccine.


Standization of both cultural and serological methods for mycoplasma clinical research.


Killing or protection of Salmonella typhimurium mutants by mammalian sera.


Metronidazole effect on social drinkers.


Alcoholic cardiomyopathy: a critical review.


Combined use of disulfiram and metronidazole in treatment of alcoholism.


Multiple molecular forms of glutamine synthetase produced by enzyme catalyzed adenylation and deadenylylation reactions.


Adsorption of ribonucleic acid on Bentonite.


Causes of damage to tissues by polymers and elastomers used in the fabrication of tracheal devices.


Australian MEDLARS Service.

Australian MEDLARS Service.


Clinical evaluation in 112 psychiatric patients of a butyrophenone neuroleptic, dehydrobenzperidol (R 4749). A controlled study in 45 patients of dehydrobenzperidol versus haloperidol.


A dipyrrylmethane intermediate in the enzymatic synthesis of uroporphyrinogen.


Effects of hepari or adenosine triphosphate infusion on the function of lung autotransplants.


Acute effects of autotransplantation on pulmonary vascular resistance and blood-gas exchange in the canine lung.


Active enhancement of canine renal allografts.


Localized immunosuppression of canine renal allografts.


Liver preservation in the pig.

Liver preservation in the pig.


The development of a transportable, experimental, liver-preservation apparatus.


The effect of liver damage and immunosuppression on canine auxiliary iiver transplantation.


Histamine or pentagastrin stimulation in the assessment of gastric secretion in children.


The use of radioactive fibrinogen as a means for detecting rejection of human renal transplants.


The effect of Trasylol on graft rejection.


The effect of intra-operative calf muscle stimulation on the prevention of postoperative deep-vein thrombosis.


The mechanism by which senna glycosides and related compounds stimulate peristalsis in the human colon.


The shapin of psychiatry by science and humanism. II. An emerging synthesis of science and humanism.


Galen's six non-naturals: a bibliographic note and translation.


Coumarins of umbelliferous plants.

Coumarins of umbelliferous plants.


Hans Driesch and the theory and practice of embryonic transplantation.


Smooth muscle antibody in bronchial asthma.


Professor Jan Hromada, M.D., DSc.

Professor Jan Hromada, M.D., DSc.


Duration of hospitalization prior to surgery.


Wallace's earliest observations on evolution; 28 December 1845.


J. C. Greene to direct PHS dental division.


Vascular diseases.

Vascular diseases.


Stifle disease (gonitis) in horses: clinicopathologic findings and intra-articular therapy.


Review of work in non-tubercular chest diseases in India over the last 25 years.


The haemoglobin in the condensed chromatin of mature amphibian erythrocytes: a further study.


The Devonshire colic. (Sir George Baker), (James Hardy).


Detection by immunofluorescence of surface antigens in cells from tumours induced in hamsters by adenovirus type 12.


Immunological unresponsivensss in parasitic infections.


Ernest H. Starling (1866-1927), the clinician's physiologist.


Patrick William Shanahan.

Patrick William Shanahan.


John Burstall Turner.

John Burstall Turner.


Fees.

Fees.


Hemopexin.

Hemopexin.


Trimodal response of Escherichia coli and Proteus mirabilis to penicillins.


Aristotle's midwife.

Aristotle's midwife.


Anemia during physical training (sports anemia).


Sodium-amino acid interaction in transport in vivo.


Prothrombin synthesis in the rat.

Prothrombin synthesis in the rat.


David Camden DeLeon, M.D. Patriot or traitor?


Sequential translation of trinucleotide codons for peptide bond formation, translocation, and termination. The addition of GUA, valyl-tRNA, T factor, GTP, and ethanol to reactions containing fMet-tRNA.AUG.ribosome intermediate results in the synthesis of fMet-valyl-tRNA which can be translocated if G factor is also present. The translocated peptidyl-tRNA can interact with puromycin to form fMet-Val-puromycin. Release of fMet-valine can also take place after translocation if a terminator trinucleotide and its specific release factor are present.


The concept of immunological surveillance.


Effects of immunity on transmission of influenza: experimental studies.


Recent advances in the unerstanding and management of metabolic bone disease.


Replication and functions of myxovirus ribonucleic acids.


RNA oncogenic viruses: structure, replication, and oncogenicity.


Repeated or habitual abortions.

Repeated or habitual abortions.


Computer diagnosis or, it is earlier than you think.


Tehe effect of certain mono-functional methanesulphonoxy-alkanes on haemopoietic colony forming units in the rat.


Micro-magnetic stirring bars for rapid electron-microscopic tissue fixation.


Incorporation of 14C- and 3H-thymidine in lymphocytes after extracorporeal irradiation of the blood.


Rapid isolation of single-cell clones of mammalian cell cultures.


Ultrastructural changes in Bacterionema matruchotii induced by an osteolathyrogen.


Effect of chloramphenicol on the conversion of dormant Azotobacter cysts into vegetative cells.


Rapid method for implantation of brain electrodes.


A new, simple, rapid procedure for purification of Escherichia coli alkaline phosphatase.


Photometric analysis of proteins and peptides at 191-194 millimicrons.


Disruption of myofibrils in the skeletal muscle of psychotic patients.


Nineteenth Rheumatism review.

Nineteenth Rheumatism review.


Ankylosing spondylitis.

Ankylosing spondylitis.


Rheumatoid arthritis (RA).

Rheumatoid arthritis (RA).


Rheumatic fever.

Rheumatic fever.


Arthritis associated with enteritis.

Arthritis associated with enteritis.


Reiter's syndrome.

Reiter's syndrome.


Sarcoidosis.

Sarcoidosis.


Sjogren's syndrome.

Sjogren's syndrome.


Autoimmunity.

Autoimmunity.


Juvenile rheumatoid arthritis.

Juvenile rheumatoid arthritis.


Behcet's syndrome.

Behcet's syndrome.


Psoriasis and arthritis.

Psoriasis and arthritis.


Scleroderma.

Scleroderma.


Cytotoxic drugs.

Cytotoxic drugs.


Systemic lupus erythematosus.

Systemic lupus erythematosus.


Chondrocalcinosis.

Chondrocalcinosis.


Miscellaneous disorders of muscle. Vacuolar myopathy.


Polymyositis and dermatomyositis.

Polymyositis and dermatomyositis.


Physical studies on ribonucleic acid polymerase from Escherichia coli B.


Neuropathic joints. Degenerative joint disease.


Hemarthrosis.

Hemarthrosis.


Separation of mitochondrial and cytoplasmic peptide chain elongation factors from yeast.


Miscellaneous types of arthritis.

Miscellaneous types of arthritis.


Joint structure and function.

Joint structure and function.


Alcaptonuria.

Alcaptonuria.


Synovitis.

Synovitis.


Chondritis.

Chondritis.


Diseases of bone and cartilage.

Diseases of bone and cartilage.


Antiinflammatory drugs.

Antiinflammatory drugs.


Experimental models of arthritis and related connective tissue diseases and some naturally occurring counterparts in animals.


Antirheumatic drugs: effects and toxicity.


Fuller Albright 1900-1969. President, Endocrine Society, 1946-1947.


Qualitative difference between bleomycin and radiation effects on cell viability.


Immunologic enhancement of renal allografts in the rat. I. Dissociation of graft survival and antibody response.


The purification and properties of dethiobiotin synthetase.


Feedback mechanisms in relation to ovulation.


The structural roles of amino acid residues near the carboxyl terminus of bovine pancreatic ribonuclease A.


Dermoid tumors of the spinal cord.

Dermoid tumors of the spinal cord.


A phosphoenzyme intermediary in acetate kinase action.


Comparative study of two hand-held respirators.


Hans Reiter (1881- ). Reiter's syndrome.


Serratia marcescens endocarditis.

Serratia marcescens endocarditis.


Serratia marcescens. A pathogen of increasing clinical importance.


Diagnostic specificity of Widal's reaction for typhoid fever.


Pyridinolcarbamate treatment of atherosclerosis obliterans analysed by toe plethysmography.


Experimental encephalopathy in Tyzzer's disease of mice.


Medical society of the District of Columbia. IV. Medical publications of the Society.


Segmental defects in open fractures of long bones.


Psychiatric changes in patients treated with levodopa. I. The clinical experiment.


Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders.


Double-blind, placebo-controlled study of levodopa therapy in Parkinson's disease.


Effect of donor bone marrow transplantation on canine renal allotransplants.


Prolongation of canine renal allograft survival in combined therapy with rabbit-anti-dog antilymphocytic serum, azathioprine and the allotransplantation of the donor's bone marrow.


Experimental endotoxin shock. The effect of hypothermia on outcome.


Fetal endocrine and renal disorders: clues to the origin of hydramnios.


Recollections of my father.

Recollections of my father.


The relevance of Adler's psychology to present-day theory.


Alfred Adler: a historical perspective.

Alfred Adler: a historical perspective.


Adler's psychology and group psychotherapy.


Benjamin Rush and the Negro.

Benjamin Rush and the Negro.


The social psychiatry of Frantz Fanon.

The social psychiatry of Frantz Fanon.


Evaluation of an amitriptyline-perphenazine combination in chronic schizophrenia.


Dimensions of affective expression in four expressive modes.


Changes in hypothalamic FSH-RF and pituitary FSH during the estrous cycle of rats.


Metabolic clearance rates and the interconversion factors of estrone and estradiol-17 beta in the immature and adult female rat.


Lithium in psychiatry.

Lithium in psychiatry.


Drug treatment in psychiatry.

Drug treatment in psychiatry.


The nerve weakness of the 19th century.

The nerve weakness of the 19th century.


Fuller Albright 1900-1969, President, Endcrine Society, 1946-1947.


Use of a tailored abdominal pedicle flap for surgical reconstruction of the hand.


Antecedent to neurosis.

Antecedent to neurosis.


The clarification of discrepancies in cortisol secretion rate.


Automation of psychiatric case records.

Automation of psychiatric case records.


Safe and prophylactic.

Safe and prophylactic.


The diffusion of growth hormone into thoracic duct lymph in man.


Effects of insulin and growth hormone on the flux rates of plasma glucose and plasma free fatty acids in man.


The ambiguous word "anxiety".

The ambiguous word "anxiety".


Does prolonged pretreatment with large doses of spironolactone hasten a recovery from juxtaglomerular-adrenal suppression in primary aldosteronism?


Increased release of LH after administration of LH-RH to men pretreated with clomiphene.


Limited role in clinical decisions.

Limited role in clinical decisions.


Metabolism of two acaricidal chemicals, N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine (chlorphenamidine) and m-([(dimethylamino)methylene]amino)phenyl methylcarbamate hydrochloride (formetanate).


More gain than pain.

More gain than pain.


Metabolism of insecticidal methylcarbamates in animals.


DNA polymerase II.

DNA polymerase II.


Induction in vitro of hapten specific plaque forming cells.


Antigenic determinants in amyloid deposits.


Aortic valve replacement: new techniques, hydrodynamics, and clinical results.


Direct and indirect myocardial revascularization: follow-up and appraisal.


Some guidelines for the advancement of surgery.


Lambda phage transduction of the bio A locus of Escherichia coli.


ES18, a general transducing phage for smooth and nonsmooth Salmonella typhimurium.


Reduced immunity in lysogens of bacteriophage lambda due to a mutation in the prophage.


Temperature-sensitive mutants of serratia phage Kappa.


The effect of freezing and DEAE-D in spheroplast assays.


Computer applications to biochemical kinetics.


The biochemistry of RNA bacteriophage replication.


Glycoproteins.

Glycoproteins.


A sensible look at air pollution by metals.


Studies on the influence of the bursa of Fabricius on the immunologic response and transplantation barrier in chickens.


Oxazepam before dental treatment.

Oxazepam before dental treatment.


The treatment of enuresis; further clinical experience with imipramine.


Combination chemotherapy using L-asparaginase, daunorubicin, and cytosine arabinoside in adults with acute myelogenous leukaemia. Cytosine arabinoside and daunorubicin used in an intensive intermittent regimen have been shown to be an effective combination for the induction of complete remissions in 14 out of 23 adult patients with acute myelogenous leukaemia. This gives an overall complete remission rate of 60%. A further patient had a good partial remission. The addition of L-asparaginase to the regimen has not increased the incidence of remission and there were more side effects in the L-asparaginasetreated group. Of the 10 patients treated with L-asparaginase in addition to cytosine arabinoside and daunorubicin, five achieved a complete remission. Of the 13 patients treated with cytosine arabinoside and daunorubicin without L-asparaginase, nine achieved a complete remission and one a good partial remission.


Home health service developed with the inception of Medicare.


Nitrous oxide--a study of physiological and psychomotor effects.


Occusal wear in prosthodontics.

Occusal wear in prosthodontics.


William Halsted, surgeon, pioneer in oral nerve block injection, and victim of drug experimentation.


Role of bacterial growth inhibitors in urine in diagnostic culture. Frequently no growth is obtained on ordinary cultures from urines of patients with typical symptoms of infection, and sometimes not even from those with pyuria. The possibility that this could be due to antibacterial substances-whether endogenous or exogenous from non-specific medication-has been investigated.


Psychological development--predictions from infancy.


Heat-stable and density mutants of phages T1, T3 and T7.


Elution of antibodies from biopsy tissue. Cryostat sections proved to be sufficient material for acid elution of bound antibodies in vitro or in vivo. By single reconstitution of the pH the eluate may be studied for antibodies with the immunofluorescence technique. This micro-elution method may be of value for the study of kidney biopsy tissues.


Genital candidasis and oral contraceptives.


Postabortal and postpartum tetanus.

Postabortal and postpartum tetanus.


A method of treating vaginal vault prolapse.


Evidence for a possible endogenous antigen in chronic inflammation.


Immunofluorescent localisation of chorionic gonadotrophin in the placenta and in tissue cultures of human trophoblast.


A new concept in the early excision and immediate grafting of burns.


Operative treatment of fractures of the dorsal and lumbar spine.


Greater vulnerability of the infecting viral strand of replicative-form deoxyribonucleic acid of bacteriophage phi X174. Four types of phiX-infected cells of Escherichia coli CR, a thymine-requiring strain of E. coli C, were prepared in which the parental replicative-form deoxyribonucleic acid (RF DNA) was labeled with same specific amounts of bromouracil in (i) both strands, (ii) only the infecting viral strand, (iii) only the complementary strand, and (iv) neither strand. The sensitivity of each type of infected cell toward irradiation by ultraviolet light, visible light, and X rays was measured. The results indicate that a certain amount of radiation damage in the infecting viral strand of the parental RF was more inhibitory to the production of progeny phage than when the damage was in the complementary strand. Similar conclusions were also drawn from "suicide" experiments of the phage-infected complexes containing (32)P of the same specific activity on either strand of the parental RF DNA. The results suggest that the beta decay occurring in the infecting viral strand was more effective in inactivating the plaque-forming ability of the complex.


Terence Edward Cawthorne. Kt, F.R.C.S., Hon. M.D. (Uppsala), Hon. LL.D. (Syracuse) 1902-1970.


Oxygen toxicity in man. A prospective study in patients after open-heart surgery.


Causes of pulmonary oxygen toxicity.

Causes of pulmonary oxygen toxicity.


Silver Anniversary of water fluoridation.


Oxygen toxicity in man. A prospective study in patients with irreversible brain damage.


Clinical chemistry in New Zealand.

Clinical chemistry in New Zealand.


The Bird Mark 7 Ventilator.

The Bird Mark 7 Ventilator.


The revolt of youth: some historical comparisons.


Postadolescence (youth) and historical change.


Sex differences in reaction to frustration among adolescents.


A method of trachelorrhapy using non-absorbable sutures.


The experimental trial of new drugs in man.


Sigmund Freud and Thomas Mann.

Sigmund Freud and Thomas Mann.


Notes on identification. I. Origins in Freud.


Our permissive society and the superego. Some current thoughts about Freud's cultural concepts.


A journey of a Danish physician and scientist to Hungary in 1669.


The Central Veterinary Society.

The Central Veterinary Society.


Psychiatry in the Arab East.

Psychiatry in the Arab East.


Human and computer attempts to decode symptom language.


Noise problems in aeromedical evacuation operations.


Renal allografts in HL-A matched recipients. Light, immunofluorescence and electron microscopic studies.


Physiology and physiopathology of the reticuloendothelial system.


Sedimentation properties of anthranilate synthetase from osmotic lysates of a wall-less variant of Neurospora.


The identification of 3'-hydroxyl nucleoside terminus of RNA chains released in the DNA-dependent RNA polymerase reaction.


Conversion of proinsulin to insulin in a subcellular fraction from rat islets.


Antibodies to transfer RNA obtained with covalently linked tRNA conjugates.


Absence of thiolated nucleotides in ribosomal RNA of E. coli.


An agar plate method for screening and enumerating pectinolytic microorganisms.


The fluorescent antibody test for the identification of strains of Clostridium botulinum type E.


Metabolism of serine and glycine in E. coli K12. I. The role of formate in the metabolism of serine-glycine auxotrophs.


A comparative study of some properties of the phi-X174 type bacteriophages.


Malignant lymphomas of the pharynx.

Malignant lymphomas of the pharynx.


Evidence for human cancer immunity. A review.


Faculty of medicine: historical collection.


Volvulus of the sigmoid colon or the saving of George.


Evaluation of methods for myocardial protection during extended periods of aortic cross-clamping and hypoxic cardiac arrest.


Cardiac preservation.

Cardiac preservation.


Intracellular localization and heterogeneity of alkaline phosphatase of Yoshida ascites sarcoma.


Time dependence of the number of histocompatibility loci in skin graft rejection of mice.


Nursing homes face increasing degree of regulation.


Ninety-third Critical Bibliography of the history of science and its cultural influences: (to January 1968).


Specific inhibition of an anti-hapten immune response by chemical modifications of cells.


Thymus dependency of the immune response to hemocyanin: an evaluation of the role of macrophages in thymectomized mice.


Immunosuppression by leukemia viruses. IV. Effect of Friend leukemia virus on antibody-precursors as assessed by cell transfer studies.


Lymphocytotoxic antibody response to cardiac allotransplantation in man. I. Correlation with post-transplantation clinical course.


The mitogenic effects of endotoxin and staphylococcal enterotoxin B on mouse spleen cells and human peripheral lymphocytes.


Mechanisms of endotoxin tolerance. VII. The role of the liver.


Precursor cells in density fractions of lymph node cells: relation to antibody-producing cells.


Biologic activities of lymph node cells fractionated on bovine plasma albumin.


Cells involved in the immune response. XX. The "all or none" nature of the primary immune response (19S antibody) by individual antibody-forming cells in the rabbit.


Plaque-forming cells of two different origins in single hemolytic foci.


Transplantation of organ cultures of adult human skin.


Mixed membranous and proliferative glomerulonephritis. A correlative light, immunofluorescence, and electron microscopic study.


Paul Bailliart.

Paul Bailliart.


The toxic actions of pyrrolizidine (senecio) alkaloids.


Drugs producing diabetes through damage of the insulin secreting cells.


Quantifying bacteria on poultry carcass skin.


Documentation of the alcohol literature.


Acaricide residues on citrus foliage and fruits and their biological significance.


Interaction of pesticides with aquatic microorganisms and plankton.


Pesticide regulations and residue problems in Poland.


The photochemistry of halogenated herbicides.


Tolerances of pesticide residues in Czechoslovakia.


Terminal residues of pyrethrin-type insecticides and their synergists in foodstuffs.


The relationship of interests to social acceptance of educable mentally retarded boys in a school camping program.


Structure and function of gamma M macroglobulins.


The use of aural cytology in the diagnosis of various inflammations and malignant tumors.


Chronic Salmonella bacteriuria complicating lymphosarcoma.


Computerized microdissection of cellular images.


In memoriam. Raymond S. Kibler, M.D. 1917-1969.


Membership roster of the International Academy of Cytology.


Calcitonin 1970: review of recent developments.


Antagonism by a gram-positive coccus.

Antagonism by a gram-positive coccus.


The effects of corticosteroids on rabies in mice.


Fate of Bacillus thuringiensis in soil: effect of soil pH and organic amendment.


Expression of the lac operon in Escherichia coli infected with RNA phage R23.


Metabolic control in Acinetobacter sp. I. Effect of C4 versus C2 and C3 substrates on isocitrate lyase synthesis.


Areas of the brain stimulatory to LH and FSH secretion.


Henry H. Turner (1892-1970).

Henry H. Turner (1892-1970).


The stimulus-secretion coupling of glucose-induced insulin release. 3. Uptake of 45 calcium by isolated islets of Langerhans.


Hemangioendotheliosarcoma of Meckel's diverticulum. A review of the literature.


Adlerian view of the present-day scene.

Adlerian view of the present-day scene.


Alfred Adler and the current mental health revolution.


The Abraham Flexner Award. Dr. Eugene A. Stead, Jr.


The Borden Award. Dr. Robert A. Good.

The Borden Award. Dr. Robert A. Good.


Determination of glutamic acid decarboxylase activity using a PH-STAT apparatus.


Sphingolipid long chain bases.

Sphingolipid long chain bases.


Studies on the ascending pathways from the thermosensitive region of the spinal cord.


Purkinje cell activation by stimulation of the labyrinth.


Earlobe composite grafts for the correction of nasal defects.


Experimental study of prevention of tip necrosis in ischemic Z-plasties.


Classification of pharyngostomes: a guideline for closure.


The blood vessel system of free human skin grafts.


Differences in the delay phenomenon in the rabbit, rat, and pig.


The classic reprint: Nasal reductions.

The classic reprint: Nasal reductions.


Reconstruction of the dural canal in myelomeningocele. Case report.


Bisensory presentation of information.

Bisensory presentation of information.


Variable cellular composition of Chromatium in browing cultures.


The myeloproliferative disorders.

The myeloproliferative disorders.


Purification and molecular properties of allosteric phosphoenolpyruvate carboxylase from Escherichia coli.


Binding of 5 S ribosomal ribonucleic acid to the unfolded 50 S ribosomes of Escherichia coli II.


Effect of calcium ions on synthesis of T5-specific proteins.


Effect of calcium ions on synthesis of T5-specific ribonucleic acid.


The B protein of Escherichia coli tryptophan synthetase. I. Effects of sulfhydryl modification on enzymatic activities and subunit interaction.


The amino acid sequence of a peptide containing the active center disulfide of thioredoxin reductase from Escherichia coli.


A thioredoxin induced by bacteriophage T4. 3. Amino acid sequence around the active center disulfide.


Superoxide dismutase from escherichia coli B. A new manganese-containing enzyme.


Purification of peptidyl transfer ribonucleic acid from rabbit reticulocyte ribosomes.


Henry Marshall (1775-1851) and the health of the British Army.


The Norwich school of lithotomy.

The Norwich school of lithotomy.


A drawing for the Fabrica; and some thoughts upon the Vesalius muscle-men.


A survey of some of the manuscripts of the Biblioteca Lancisiana in Rome.


The medical students' oath of ancient India.


Early American English translations of European medical works.


Richard Dadd (1817-1886): painter and patient.


The 'bubu'tu' lesion in antiquity.

The 'bubu'tu' lesion in antiquity.


Charles Donald O'Malley. 1 April 1907-7 April 1970.


Antidiuretic hormone synthesis, release, and action under normal and pathological circumstances.


The use of liquid formula diets in metabolic studies: 15 years' experience.


Polyhydramnios: chronic versus acute.

Polyhydramnios: chronic versus acute.


Therapy of female gonorrhea with cephaloridine.


Irradiation and radiocontamination during pregnancy.


Esophageal perforations.

Esophageal perforations.


Humanism is not enough.

Humanism is not enough.


Molybdate toxicity in Salmonella typhimurium.


Changes in polyribosome metabolism in Escherichia coli K12 after adsorption of colicin E3 to sensitive cells.


Radioautographic studies of the initial site of formation of protein-bound iodine in the rat thyroid gland. 1. Predominantly cellular labelling was observed in radioautographs of rat thyroid glands fixed by perfusion from the aorta at intervals between 5 and 55s after [(125)I]iodide administration via the aorta. 2. When perfusion was delayed for 2min, or if immersion fixation was used, the labelling was predominantly over the peripheral portion of the follicular lumen, in agreement with the observations of other investigators. 3. The findings support the concept that the initial site of binding of iodine to protein is intracellular, but the nature of this protein has not been established.


Cellular differentiation in skeletal tissues.


Dietary fibre and the pruritus of cholestatic jaundice.


Delayed psychosomatic skin disorders in survivors of concentration camps.


Simple technique for recession of the inferior oblique muscle.


Relationship between Rm values and antibiotic activity of rifamycins against E. coli and Staph. aureus.


Regulation of the immune response. II. Further studies on differences in ability of F(ab')2 and 7S antibodies to inhibit an antibody response.


Radioautographic study of cellular mechanisms in delayed hypersensitivity. IV. Distribution of injected lymph node, spleen, thymus and bone marrow cells.


Quantification of immunofluorescence on individual erythrocytes coated with varying amounts of antigen.


Allotypic suppression of adult mouse spleen cells.


In vitro neutralization of the Shwartzman-inducing activity of endotoxins by immune serum.


The relationship between lymphocyte transformation and immune response. 3. Kinetics of production of antibody forming cells and transforming cells.


The role of the sixth component of complement in the rejection of kidney xenografts.


On the participation of antibodies and complement in the antibacterial activity of an extract from rabbit polymorphonuclear leucocytes.


Detection of cell surface antigens on monolayer cells. II. The application of mixed haemadsorption on a micro scale.


In vitro stimulation of antibody formation by peritoneal cells. 3. Effect of active immunization on the subsequent in vitro performance of peritoneal and spleen cells.


The effects of RES 'blockade' on antibody formation. IV. Inhibition of plaque-forming cells in spleen cultures treated with carbon particles.


An endonuclease induced after infection of Escherichia coli with bacteriophage T7. I. Purification and properties of the enzyme.


An endonuclease induced after infection of Escherichia coli with bacteriophage T7. II. Specificity of the enzyme toward single- and double-stranded deoxyribonucleic acid.


The specific acylation of glycerol 3-phosphate to monoacylglycerol 3-phosphate in Escherichia coli. Evidence for a single enzyme conferring this specificity.


Inhibition of pepsinogen activation by gossypol.


Effects of the depth of culture medium on elongation of Mycobacterium lepraemurium in vitro.


A comparative study of mouse foot pad inoculation of skin biopsy specimens from patients with lepromatous leprosy in San Francisco and Atlanta.


A message from the president. On the International Leprosy Association.


Duration of specific treatment in leprosy.


Posteruptive effects of nutrition on teeth.


Preeruptive effects of nutrition on teeth.


Experimental onlay bone grafts to the jaws. A preliminary study in dogs.


Delayed bone grafting in cleft palate patients.


Trace elements and caries.

Trace elements and caries.


Vaginal reconstruction folowing extended abdominoperineal resection.


Formation and accumulation of acid on the tooth surface.


Effects of diet on salivary secretion and composition.


Indomethacin in superficial thrombophlebitis.


No medicine for the poor. A gleaning from Scottish victoriana.


Magna Carta and the Hospital of Sant'Andrea, Vercelli.


Enamel protective factors in food.

Enamel protective factors in food.


Rehabilitation in the services. I. The Royal Navy.


Rehabilitation in the services. II. The army.


Fascia lata composite graft for right ventricular outflow tract and pulmonary artery reconstruction. Surgical technique.


Coffee worker's lung. A new example of extrinsic allergic alveolitis.


A simple method for short-term (6-hour) transport of the dog heart prior to orthotopic transplantation.


Translocation of the atrial septum.

Translocation of the atrial septum.


Actinobacillus actinomycetem-comitans: fermentative capabilities of 140 strains. Fermentative capabilities of 140 strains of Actinobacillus actinomycetem-comitans were studied. Findings correspond closely with those reported previously by Heinrich and Pulverer (12 strains), and by King and Tatum (33 strains). All strains ferment glucose, levulose, and maltose and reduce nitrate to nitrite. Reactions with glycogen and starch are exceedingly diverse. Eight different biotypes have been identified on the basis of their reactions with galactose, mannitol, and xylose.


Growth of Pseudomonas fluorescens with sodium maleate as a carbon source. The growth of Pseudomonas fluorescens (ATCC 11150) on sodium maleate was observed, and the composition of the media was monitored in batch culture. Utilization of the maleate as the sole organic carbon source proceeded by stepwise conversion to fumarate and then to malate. Respiration rates of P. fluorescens on maleate, mixtures of maleate and fumarate salts, and mixtures of maleate and malate salts were measured. Complex effects, possibly due to a change in metabolic mechanism, were observed.


Effect of bile and desoxycholate on gram-negative anaerobic bacteria. The bile tests for characterizing gram-negative anaerobic bacilli were reevaluated in prereduced anaerobically sterilized peptone-yeast-glucose broth, in thioglycollate broth, and on blood agar plates. Blood agar plates were unsatisfactory. The combination of 20% bile with 0.1% desoxycholate inhibited Fusobacterium, Bacteroides melaninogenicus, and B. oralis and sometimes Sphaerophorus necrophorus, but not B. fragilis or other Sphaerophorus species studied. Ten per cent bile with 0.05% desoxycholate was less satisfactory. There was no significant difference between fresh and commercial powdered bile. Desoxycholate (0.1% in thioglycollate broth) inhibited B. fragilis, Fusobacterium, B. melaninogenicus, B. oralis, and S. necrophorus, but not S. varius or S. mortiferus/S. ridiculosus. The bile and desoxycholate tests are simple to perform and helpful for characterization and classification of gram-negative anaerobic bacilli.


Growth responses of Escherichia coli to the surfactant dodecyl benzene sulfonate. When strains of Escherichia coli are grown in broth cultures containing the anionic surfactant sodium dodecyl benzene sulfonate (NaDDBS), they exhibit unique growth responses. After 20 to 24 hr of incubation, they become slimy and viscous, and an addition of ethanol to the supernatant liquid yields a distinctive white, fibrous precipitate. The production of this material was shown to be dependent on the presence of NaDDBS in the medium. This precipitate from E. coli ATCC 11303 was found to contain 41 to 53% protein, 10 to 11% deoxyribonucleic acid, 6.8 to 7.4% ribonucleic acid, 15 to 25% carbohydrate, and 9% lipid. It is distinctive from naturally occurring E. coli slimes in several respects. Our data suggest that its formation is the primary result of the leakage of intracellular components into the medium. However, the rate of cell proliferation indicates a partial but not complete or lethal lysis. A limited utilization of NaDDBS as a carbon source was also shown.


Distribution of bacteria in feces of swine. A new technique is described for evaluating bacterial cell distribution in fecal samples. Spatial relationships of cells within an area rather than number of cells per unit volume or weight are measured by this technique. Measurements of cell distribution by this method indicated that bacteria occurred in freshly voided swine feces as pure, discrete colonies rather than as single cells distributed randomly or uniformly throughout the sample.


Synergistic false-positive coliform reaction on M-Endo MF medium. The reported occurrence of synergistic false-positive coliform reactions on M-Endo MF medium was investigated. The objectives of the study were (i) to isolate populations of bacteria which produced such false-positive reactions, (ii) to determine whether false-positive sheen reactions are a result of synergistic interaction, and (iii) to determine the metabolic intermediates involved in false-positive sheen production. Samples of river water were subjected to coliform analysis by the membrane filter technique with M-Endo MF medium. Suspect sheen-forming colonies were analyzed to determine purity and identity of cultures. Mixed cultures were separated, and individual isolates were examined for sheen production. The isolates not producing a sheen were recombined and tested further for sheen production. Those mixtures reproducing the sheen were characterized biochemically and tested to determine the metabolic intermediates involved. Chromatographic analysis of the metabolites showed that individual isolates produced an assortment of neutral organic compounds including 2-butanone, 2,3-butanedione, formaldehyde, and butyraldehyde, whereas acetaldehyde or propionaldehyde was produced only by the mixed cultures. Tests showed that both propionaldehyde and acetaldehyde could react to produce a sheen on M-Endo medium. The conclusion was reached that synergistic false-positive coliform reactions do indeed occur on M-Endo MF medium.


Effect of sodium fluorescein and plating medium on recovery of irradiated Escherichia coli and Serratia marcescens from aerosols. Irradiation of aerosols of either Escherichia coli or Serratia marcescens with simulated solar (xenon) radiation caused a significant decrease in viability. When sodium fluorescein was employed to determine the physical loss of organisms from the aerosol, an additional adverse effect upon survival was noted. The decay curves indicated that at least two mechanisms of inactivation were operative, one due to aerosolization, the other to irradiation. After collection from aerosols, both species of microorganisms grew better on blood agar base than on Casitone agar, but this finding did not appear to be related to the effect of irradiation.


Motility-indole-ornithine medium.

Motility-indole-ornithine medium. A medium designed for detection of motility, indole, and ornithine decarboxylase production in one tube was devised and evaluated. Results, using 182 strains of Enterobacteriaceae, were the same as obtained with commonly used standard methods, although 11 of 87 positive indole tests were weak with the new medium.


Comparison of two plating media for detection of Salmonella from swine tissues. Xylose-lysine-Brilliant Green-agar and Brillian Green-sulfadiazine-agar were used to isolate salmonellae from swine tissues. There was no significant difference between the efficiency of the two media.


Effect of pentagastrin on gastric HCl secretion and histamine content of the stomach of rats.


Immunofluorescent identification of Pneumocystis carinii.


Transplantation of HL-A identical allogeneic bone marrow to a patient with acute lymphocytic leukemia.


A difference between spleen-derived and bone marrow-derived colony-forming units in ability to protect lethally irradiated mice.


Bell's phenomenon and corneal lenses.

Bell's phenomenon and corneal lenses.


Immunological effect of E.coli L-asparaginase.


Rheumatoid arthritis. Aetiology.

Rheumatoid arthritis. Aetiology.


Effects of isoprenaline plus phenylephrine by pressurized aerosol on blood gases, ventilation, and perfusion in chronic obstructive lung disease. The effects of a combined isoprenaline-phenylephrine inhalant in chronic obstructive lung disease were assessed in 23 patients. Significant changes occurred in blood gas tensions after inhalation, together with an overall improvement in ventilation/perfusion ratios. Cardiac output and physiological shunt were not significantly increased. Hence the addition of phenylephrine probably prevents the increase of hypoxaemia which may result from the disproportionate ventilation/perfusion ratio produced by sympathomimetics or xanthines used alone. The combination aerosol has a satisfactory bronchodilator effect, and is additionally safe if used by a severely hypoxic patient unaware of the seriousness of his condition.


Rheumatoid arthritis. Medical management.


Early x-rays.

Early x-rays.


Escherichia coli disease in the piglet. A pathological and bacteriological investigation.


Rheumatoid arthritis. Surgical treatment.


Response of beta cells to different levels of glucose: fetal pancreases grown in organ culture and subsequently transplanted to maternal hosts.


Advances in nitrile oxides chemistry.

Advances in nitrile oxides chemistry.


Uptake and localization of radioactive zinc in the visceral complex of the land pulmonate Arion rufus.


Effects of vaginal stimulation on hypothalamic single units in unanesthetized rabbits.


Analysis of results of bacteriological examination of morbid materials from cases of sheep pneumonia during the period, 1959-1968.


Optometric visual training--its history and development.


Restoration of systemic blood flow to the lung after division of bronchial arteries.


Determination of contained-milk volume of the mammary gland of the goat by cerium and 14C-PEG-4000.


The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations.


Peritoneal clearance of urea and potassium and protein removal during acute peritonitis in dogs.


The fluorescent treponemal antibody-absorption test: a micromethod.


An attempt to improve tolerance to homografts in chickens by selection.


Observations concerning the use of 1-methyl-2-carbamoyloxymethyl-5-nitroimidazole against experimentally induced histomoniasis in turkey poults.


Recent advances in avian endocrinology. 3. Endocrine control of calcium homeostasis in the fowl.


Antibody and cell mediated immunity in corticosteroid-treated chicks.


Beginning a multidimensional theory of creativity.


Sociometric status in a psychiatrically deviant adolescent collectivity.


Leadership roles in a psychiatrically deviant adolescent collectivity.


Level of aspiration and locus of control in disadvantaged children.


Chronic granulomatous disease of childhood. Hematogenous osteomyelitis due to non-pigmented Serratia marcescens.


Adverse reactions to oral contraceptives. Report of a case of cholestasis.


Examination of the inflammatory reaction in ulcerative colitis by use of the skin-window technique.


Dose-response relationship of the efect of secretin on acid and pepsin secretion in man.


Progesterone: how did the name originate?


The isolation and study of an unidentified factor from the haemolymph of Rhodnius prolixus.


Human trypanosomiasis in Ethiopa. Ecology of Illubabor Province and epidemiology in the Baro River area.


Studies on the chemotherapy of malaria. II. Pyrimethamine resistance in The Gambia.


Studies on the chemotherapy of malaria. I. The treatment of overt falciparum malaria with potentiating combinations of pyrimethamine and sulphormethoxine or dapsone in The Gambia.


Yaws eradication in Indonesia: Dr. Raden Kodijat's contribution.


New skin diseases in Africa.

New skin diseases in Africa.


The collection of vaginal smears from bitches.


Neuro-ophthalmology. A review.

Neuro-ophthalmology. A review.


Avian infectious bronchitis.

Avian infectious bronchitis.


Hypervitaminosis A of the cat.

Hypervitaminosis A of the cat.


Glucose synthesis in ruminants.

Glucose synthesis in ruminants.


In vitro cultivation of nematode parasites important to Veterinary Medicine.


Canine and feline neoplasia.

Canine and feline neoplasia.


Inhibition of cardiovascular metabolic and hemodynamic effects of adenosine by aminophylline.


Lobar distribution of pulmonary arterial blood flow in awake standing dogs.


Comparative evolution of the fluorescent antibodies directed against the larval stages and the adults of Schistosoma mansoni. I. Experimental schistosomiasis in untreated mice.


Comarative evolution of the fluorescent antibodies directed against the larval stages and the adults of Schistosoma mansoni. II. Experimental schistosomiasis in mice after treatment with niridazole.


Identification of Enterobacteriaceae in the clinical microbiology laboratory. A total of 5,137 enterobacterial clinical isolates were examined with three series of biochemical tests. The data were analyzed with respect to the use of economical and practical procedures for the accurate identification of lactose-fermenting and -nonfermenting Enterobacteriaceae within 24 hr after isolation.


Isolation of L-forms in a clinical microbiology laboratory. Previous studies have demonstrated that L-forms of bacteria may play a role in persistent, chronic, or recurrent urinary-tract infections. A 2-year program was initiated to determine the feasibility of culturing for L-forms on a routine basis, and to determine the effectiveness of such a program. In relation to the total number of specimens, few L-forms were actually isolated. In comparison with the amount of equipment and technician time required, the return was negligible; only 0.5% of all urine specimens were positive for L-forms. An increase to only 1.2% was noted when culturing for L-forms was limited to patients with a diagnosis of bacteriuria or pyelonephritis. It is recommended that this technique be reserved for those patients with a long history of recurrent urinary-tract infections, after other attempts to cure the patient have met with failure.


New Moraxella strain isolated from angular conjunctivitis. A new Moraxella strain was isolated from angular conjunctivitis. It is characterized by the ability to produce acid from several carbohydrates, by its ability to produce indole, and by a lack of catalase activity.


Improved bacteriophage-bacteriocin applicator. Teflon spaghetti tubing was placed over the metal needles of the dispensing head of the Accu-Drop multidropper, thus preventing the delivery of multiple drops. A metal plate was drilled so that 25 cartridges could be positioned to inoculate simultaneously 25 compartments in a divided petri dish.


Rapid procedure for the detection of acid and gas production by bacterial cultures. A rapid miniaturized procedure, with a Microtiter plate and the Amojell-overlay technique, is described for the detection of acid and gas production by bacterial cultures.


Purification, concentration, and inactivation of Venezuelan equine encephalitis virus. Venezuelan equine encephalitis (VEE) virus was purified and concentrated by chromatography of tissue culture supernatant fluids on diethylaminoethyl-cellulose columns. Stepwise gradient elution studies indicated a broad elution pattern for the virus, with recovery occurring from 0.05 to 0.7 m NaCl. Optical density, infectivity, hemagglutination (HA), and complement fixation (CF) assays indicated that complete recovery of input virus in highly purified form was possible. Single-step elution with 0.7 m tris(hydroxymethyl)aminomethane-succinate-salt buffer resulted in a virus volume decrease of 85% with a concomitant increase in infectivity and antigenicity. Recoveries consistently equaled or exceeded 100% of the input preparations. Additional purification of column-recovered virus was obtained by sedimentation of pooled virus eluates on 50% sucrose cushions. Exposure of borate saline and 0.5% histidine suspensions of purified VEE virus preparations to 6 x 10(6) r of gamma radiation resulted in a loss of infectivity for tissue culture and a loss of lethality for weanling and suckling mice. Inactivation was an exponential function of the dosage. In contrast to infectivity, antigencity (HA and CF) of both saline and histidine preparations was retained after irradiation with doses as high as 6 x 10(6) r. Purified and irradiated VEE virus preparations have been successfully used for routine serological tests and are being evaluated as vaccines.


Immunofluorescence detection of exterotoxin B produced under CO2 and N2 atmospheres. The degree of cell fluorescence of Staphylococcus aureus strains 243 and S-6 was found not to correlate with enterotoxin B production under CO(2) and N(2) atmospheres.


Nineteenth and twentieth century environmental movements.


The ultrastructure of initial stages of platelet aggregation and adhesion to damaged vessel walls in vivo.


RNA synthesis on native DNA complexes isolated from Streptomyces griseus and Escherichia coli.


Medical clerkship in five different settings.


What is the best elective operation for duodenal ulcer? During the past 40 years, after gastroenterostomy and pyloroplasty for duodenal ulcer had been replaced by partial gastrectomy in many centres, partial gastrectomy itself gave way to combinations of vagotomy with gastroenterostomy, pyloroplasty or antrectomy. Opinions differ concerning the procedure of choice and in this paper the author examines the causes of this diversity of opinion and assesses the reliability of conclusions that can be drawn about the elective treatment of duodenal ulcer today. Most reports of results from various operations have come from retrospective studies, and the causes of variability among such reports are analyzed to point out the great difficulty in making a valid judgment about the relative worth of the various operations used to treat duodenal ulcer. Results of some of the few prospective studies with randomized operations assessed blindly are then presented and note is taken of the surprising observation that greatly different operations appear to give remarkably similar results. From the data available the author develops a logical way of approaching the choice of operation for the various problems related to duodenal ulcer that require elective surgical treatment.


Pemphigus and pemphigoid: some current concepts.


Pepsin secretion in man after Histalog stimulation. Human gastric juice shows three separable pepsin fractions on chromatography on DEAE-cellulose. The response of these fractions to stimulation with beta-aminoethylpyrazole hydrochloride (Histalog) was studied. After a single intramuscular injection of Histalog (1.7 mg/kg body weight) there was an increase in the output of all three chromatographically distinguishable pepsin fractions. Little change was observed in the relative proportions of these three fractions and there was no evidence of selective stimulation of any individual fraction.


Computers in the management of shock.

Computers in the management of shock.


Cardiac output in shock.

Cardiac output in shock.


Lung function in shock.

Lung function in shock.


Respiratory therapy.

Respiratory therapy.


Hypotension and cerebral ischemia.

Hypotension and cerebral ischemia.


Hyperbari oxygen in shock.

Hyperbari oxygen in shock.


Emergency extracorporeal circulation.

Emergency extracorporeal circulation.


Myocardial infarction.

Myocardial infarction.


Factors exacerbating shoc in the tropics.


The management of snakebite.

The management of snakebite.


Hypothermia in mountain accidents.

Hypothermia in mountain accidents.


Results of a survey on bacteriologic culturing of broodmares.


Abortion and placental lesions in the mare.


Healing of articular cartilage in the horse.


Status of the mastitis-metritis-agalactia syndrome of sows.


Safety and pharmacologic evaluations of melengestrol acetate in cattle and other animals: A review.


Surgical treatment of canine hydrocephalus.


The effects of trace elements on human and animal health.


The development of transferable drug resistance in Salmonella and its public health implications.


The use of supplemental tests in the diagnosis and eradication of hog cholera.


An epizootic of Brucella melitensis infection in Texas.


A data retrieval system for disease and administrative information.


An evaluation of a fluorescent antibody technique for the detection of Salmonellae in animal by-products, feeds, and tissues.


Veterans Administration Training Program in Laboratory Animal Medicine, Science, and Technology.


Federal laboratory testing requirements for canine vaccines.


A C-terminal arginine residue necessary for bacteriophage T4D tail assembly.


Infectious nucleic acids of Escherichia coli bacteriophages. XII. Fate of double-stranded bacteriophage ribonucleic acid in Escherichia coli spheroplasts.


Transfer of parental phiX174 deoxyribonucleic acid to progeny bacteriophage particles observed at low multiplicities of infection.


Transcription of the ribosomal RNA genes of an amphibian by the RNA polymerase of a bacterium.


Interaction of bacteriophage T4 tail fiber components with a lipopolysaccharide fraction from Escherichia coli.


Tryptophan messenger translation in Escherichia coli.


Regulation at the level of translation in the arginine pathway of Escherichia coli K12.


Ribonuclease V of Escherichia coli. V. Requirement for ribosome translocation, but not for polypeptide formation.


Size determination of mitochondrial ribosomal RNA from Aspergillus nidulans by electron microscopy.


Mechanism of DNA chain growth. V. Effect of chloramphenicol on the formation of T4 nascent short DNA chains.


Identification of types of potentially cariogenic streptococci on human tooth surfaces by the fluorescent antibody technique.


Studies on the structure of ribosomes. IV. Participation of aminoacyl-transfer RNA and peptidyl-transfer RNA in the association of ribosomal subparticles.


On the process of cellular division in Escherichia coli. Membrane prtein alterations associated with mutations affecting the initiation of DNA synthesis.


DNA replication in Escherihia coli: replication in absence of protein synthesis after replication inhibition.


Chemical studies on methionyl-tRNA synthetase from Escherichia coli.


In vitro susceptibility of oral spirochetes to metronidazole.


The structure of the DNA of bacteriophage phiX174. VI. Pyrimidine sequences in the complementary strand of the replicative form.


Unbiased synthesis of pulse-labeled DNA framents of bacteriophage lambda and T4.


Isolation and characterization of the DNA replication complex from Escherichia coli.


Host specificity of DNA produced by Escherichia coli. 13. Breakdown of cellular DNA upon growth in ethionine of strains with r plus-15, r plus-P1 or r plus-N3 restriction phenotypes.


Induction of chromosome re-initiations in a thermosensitive DNA mutant of Escherichiacoli.


Effects of solvent environment and mode of preparation on the physical properties of ribosomes fron Escherichia coli.


Calcium-dependent bacteriophage DNA infection.


On the production of deletions in the chromosome of Escherichia coli.


The expression of two classes of late genes of bacteriophage T4.


Survival of xenogeneic grafts of embryonic pigment and carapace rudiments in embryos of Chelydra serpentina.


Sex-specific patterns in creative literary fantasy.


The relationship of sex role identity and social and politicalattitudes.


Multidisciplinary approach tomeningomyeloceles.


Medical conditions at Valley Forge.

Medical conditions at Valley Forge.


Cellular kinetics of 19S and 7S hemolysin production in mice under the influence of bacterial endotoxins.


An outline of iniencephaly.

An outline of iniencephaly.


Rudolf Nissen, M.D.

Rudolf Nissen, M.D.


Effect of graft removal and immunosuppression on antibody response to murine histocompatibility antigens.


Immunofluorescent studies in cardiac rejection.


Reminiscences--reflux esophagitis and hiatal hernia.


Transplantation of pedicle bone grafts to fresh skeletal defects and defect pseudarthroses. An experimental study.


Immunofluorescence studies on kidney biopsies in ankylosing spondylitis.


Demonstration of Francisella tularensis (syn. Pasteurella tularensis) in sylvan animals with the aid of fluorescent antibodies.


Financing the care of the mentally ill under Medicare and Medicaid.


A selected public health bibliography with annotations.


A mobile respiratory screening console.

A mobile respiratory screening console.


Toxothrix trichogenes (Chol.) Beger et Bringmann: the organism and its biology.


Isolation and description of a non-motile, fusiform, stalked bacterium, a representative of a new genus.


Interspecies sex-specific growth responses in Kluyveromyces.


Competitive inhibition of pepsin by carboxylic acids.


Antigenic relationships between the malaria parasites and piroplasms of mice as determined by the fluorescent-antibody technique.


Haemoglobinopathies and malaria in Thailand: a comparison of morbidiy and mortality rates.


The specificity of immunoglobulin G and immunoglobulin M in the fluorescent-antibody test for malaria parasites in mice.


A controlled clinical trial of lactulose in hepatic encephalopathy.


Edwin H. Ellison, M.D. 1918-1970.

Edwin H. Ellison, M.D. 1918-1970.


Capillary exchange modeling. Barrier-limited and flow-limited distribution.


Methods and criteria for evaluating gingival tissue reactions.


The genesis of some epithelial changes, sometimes preceding or attending the appearance of cancer of the cervix uteri (a review of comparative and experimental data).


Ribosomal proteins. XII. Number of proteins in small and large ribosomal subunits of Escherichia coli as determined by two-dimensional gel electrophoresis. Two-dimensional gel electrophoresis separates all of the component proteins of the ribosomal subunits of Escherichia coli. This method shows 21 proteins in the 30S, and 34 proteins in the 50S, subunit.


Breakdown by streptomycin of initiation complexes formed on ribosomes of Escherichia coli. Streptomycin induces breakdown of the completed 70S initiation complex on ribosomes of Escherichia coli, but it does not interfere with any step in the formation of the complex. Moreover, it does not appear to interact with the ribosome in any special way during initiation, since the kinetics of breakdown are the same whether streptomycin is added before formation of the initiation complex, or after its completion, or (as previously observed) after formation of a polypeptide. fMet-tRNA is released as such, without chain elongation; it is released from a puromycin-reactive ("P") site. Streptomycin thus appears to distort not only the A site of the ribosome (as suggested earlier) but also the P site.


Topography of the Escherichia coli 30S ribosomal subunit and streptomycin binding. Treatment of Escherichia coli 30S ribosomal subunits with trypsin sequentially removes a number of different ribosomal proteins, as revealed by polyacrylamide gel electrophoresis. Proteins that are removed early by trypsin correlate well with those that are added last during reconstitutive assembly of the 30S subunit from 16S ribosomal RNA and the total protein complement. Proteins that are resistant to removal from the subunit by the highest trypsin concentration used correlate with those that are added early during assembly. Six proteins can be removed from the subunit with trypsin without affecting its ability to bind the antibiotic streptomycin. A decline in the ability of the 30S subunit to bind streptomycin is correlated with the removal of either one, or both, of two proteins, neither one of which is the gene product of the streptomycin locus. The implications of these findings for the topography and assembly of the 30S subunit are considered.


Three-dimensional organization of the 30S ribosomal proteins from Escherichia coli. I. Preliminary classification of the proteins. 30S ribosomal subunits from Escherichia coli were reacted with three protein reagents. After reaction, the ribosomal proteins were extracted and examined; of the 20 proteins known to compose the particle, nine did not react with any of the three reagents. We have tentatively classified these proteins as "internal," and the remaining eleven as "external." A strong correlation was found between these results and the sequence of assembly. Those proteins which enter the assembly process early are classed as internal, whereas those proteins found to participate later in the assembly sequence are classed as external.


Structure and function of bacterial ribosomes. XI. Dependence of 50S ribosomal assembly on simultaneous assembly of 30S subunits. Some spectinomycin-resistant mutants of Escherichia coli are cold-sensitive. They are unable to assemble both 30S and 50S ribosomal subunits at low temperatures. They accumulate two kinds of incomplete particles, related to 30S and 50S subunits respectively. A single mutation, causing an alteration in a 30S ribosomal component, is responsible for these phenotypes. These results show that assembly of 50S subunits in vivo is dependent on simultaneous assembly of 30S subunits. On the other hand, the assembly of 30S subunits appears to be independent of 50S assembly.


Identification of the cytokinin-active ribonucleosides in pure Escherichia coli tRNA species. The distribution of the two cytokinin-active ribonucleosides 6-(3-methyl-2-butenylamino)-9-beta-D-ribofuranosylpurine (1) and 6-(3-methyl-2-butenylamino)-2-methylthio-9-beta-D-ribofuranosylpurine (2) in tRNA(Phe), tRNA(UUG) (Leu), tRNA(UCR) (Ser), tRNA(Tyr), tRNA(Cys), and tRNA(2) (Trp) from stationary phase Escherichia coli has been studied. Compound 2 predominated in all these species except tRNA(Phe), in which compound 1 was greatly in excess. Compound 1 was present in relatively small amounts in tRNA(UUG) (Leu), tRNA(Cys), and tRNA(2) (Trp), and was not detected in tRNA(UCR) (Ser) and tRNA(Tyr). Cells from the early logarithmic phase had the highest cytokinin content in their tRNA. Stationary phase tRNA had a slight increase in the amount of 1, which may be explained by the appearance of the new tRNA(Phe). No differences were observed between the chromatographic patterns of tRNAs from early-, mid-, and latelogarithmic phases.


Enzymatic carboxylation of biotin: molecular and catalytic properties of a component enzyme of acetyl CoA carboxylase. The biotin carboxylase component of acetyl CoA carboxylase has been purified approximately 2000 times from Escherichia coli. This protein, which catalyzes the carboxylation of free d-biotin, is free of the biotin-containing carboxyl carrier protein, is homogeneous by polyacrylamide gel electrophoresis and analytical ultracentrifugation, and has been crystallized. Biotin carboxylase, with a molecular weight of approximately 100,000, is composed of two 50,000-dalton subunits. The catalytic capacity of biotin carboxylase is markedly enhanced by ethanol (11 times at 15% v/v), and certain other organic solvents; this may mimic an effector-mediated response. The kinetic effect is exclusively on the maximal velocity of the reaction. Activation by ethanol is reversible and not accompanied by aggregation or disaggregation of the enzyme.


Conformations of the single-stranded DNA of bacteriophage M13. At least two conformations of M13 single-stranded DNA have been demonstrated by measuring differences in sedimentation coefficient and by direct visualization in the electron microscope. Which form is obtained from infected cells and/or intact phage depends on the pH, ionic strength, and temperature. The slower-sedimenting form can be converted to the faster-sedimenting, single-stranded form by low ionic strength, alkali treatment, formamide, or formaldehyde, but not by exposure to 100 degrees C in 1.0 M NaCl. The ability to assume either conformation appears to be a function of the nucleic acid alone. Whether or not these different conformations are of biological significance is still unknown.