Rejection of renal homografts.

Rejection of renal homografts.


Transplantation of the isolated pancreas: report on the first human case.


Granulomatous orchitis following renal transplantation.


In memoriam, Emil Adler, Chairman of the Executive Board of the Israel Journal of Medical Sciences.


In vitro investigation of the adhesive strength of cyanoacrylate bonds to human hard tooth structures.


Pathogenic Escherichia coli in a nursery.


Winter diarrhoea in Egyptian infants and children.


A comparison of Nomarski differential interference contrast and phase contrast microscopy of the guinea pig organ of Corti.


In memoriam. Theodore Edwin Walsh, 1900-1971.


Historical vignette. "The poor and solitary endeavours" of Isaac Newton, 1642-1727.


Neurology of Vibrio fetus infection.

Neurology of Vibrio fetus infection.


A controlled study of folic acid in epilepsy. A controlled study of folic acid in epilepsy.


Howard Douglas Fabing. Feb. 21, 1907-July 29, 1970.


Endodontics: then and now.

Endodontics: then and now.


Aseptic single layer anastomosis of the bowel. A review of one hundred seventy-five cases.


Malignant lymphoma in childhood. A retrospective review.


Determinants of operative risk in human heart transplantation.


Analysis of the immunosuppressive and oncogenic effects of heterologous antilymphocyte serum.


Protection of femoral vessels after groin dissection.


Diagnosis and treatment of respiratory failure after civilian trauma.


Acute rejection of the allogrfted human heart.


Radiological dissociation of alveolar and vascular phases of rejection in allografted lungs.


Corneal grafts and their effect upon the applanation Schiøtz disparity.


Optic atrophy following Caldwell-Luc procedure.


A new suture for external silicone sponge implants.


Further experience with sutureless scleral buckling materials. I. Hydrogels.


The distribution of immunoglobulin in the rabbit eye.


Further experience with sutureless scleral buckling materials. II. Cyanoacrylate tissue adhesive.


Recent antiviral chemotherapy publications.


Hemodynamic evaluation of glucagon in symptomatic heart disease.


Relationship of extraluminal tubular deposition of ferrocyanide to peritubular perfusion rate in cortical and medullary nephron segments of the rat kidney.


Measurement of heart chamber volumes by analysis of dilution curves simultaneously recorded by scintillation camera.


Myringo-tympano-mastoidoplasty.

Myringo-tympano-mastoidoplasty.


Formaldehyde-induced cross-linkages in the   subunit of the Escherichia coli tryptophan synthetase.


Composition and subunit structure of glycerol kinase from Escherichia coli.


Evidence for tighter binding of magnesium-thiamine pyrophosphate to  -ketoglutarate dehydrogenase when activated by adenosine monophosphate.


Ethnic and socioeconomic status differences in human figure drawings.


The primary structure of the Clostridium tartarivorum ferredoxin, a heat-stable ferredoxin.


Congressional considerations of Medicare and Medicaid.


Experimental studies on transfusion of blood stored at low temperatures: transfusion of frozen blood contaminated with E. coli in healthy dogs.


Myelomeningocele birth defect. Habilitation of the child.


Thrombus formation on polymeric materials. IV. Behavior of blood proteins at interfaces.


Historic hospitals. The suppression and refoundation of St. Bartholomew's Hospital.


Microbiological control in the manufacture of sterile pharmaceutical products.


Primary tumours of the small intestine.

Primary tumours of the small intestine.


The controlled clinical trial in surgery.


Delimitation of clinical materials in gastroenterology.


Postgastrectomy syndromes.

Postgastrectomy syndromes.


Harvey--the pacemaker.

Harvey--the pacemaker.


Diabetic angiopathy.

Diabetic angiopathy.


Biosynthesis of ribonucleic acid in yeast: some properties of mitochondrial ribosomal ribonucleic acid in Saccharomyces carlsbergensis.


The potential of carboxylic-phosphoric mixed anhydrides as specific reagents for enzymic binding sites for alkyl phosphates. Inactivation of an enzyme by an anhydride isosteric with adenosine 5'-phosphate.


The interaction of transfer factor G, ribosomes, and guanosine nucleotides in the presence of fusidic acid.


Study of the potential carcinogenicity of topical drug. Suggestions for a new experimental approach.


Drug abuse treatment programs. Kicking the habit.


A horse-and-buggy doctor in Hoosierland.


Respiratory therapy--what does it offer?


Male pregnancy symptoms and cross-sex identity in three societies.


Body image changes in teen-age diabetics.


Disseminated coccidioidomycosis associated with immunosuppressive therapy following renal transplantation.


Surgical correction of the cupped ear.

Surgical correction of the cupped ear.


The micro-vascular circulation of lymphangiomas: a study of Xe 133  clearance and pathology.


The Melkersson-Rosenthal syndrome.

The Melkersson-Rosenthal syndrome.


Dr. Suzanne Noël. The first woman to do esthetic surgery.


Vertical wedge ostectomy in the mandibular rami for correction of prognathism.


Closure of cleft palate.

Closure of cleft palate.


Autoallergy in burns.

Autoallergy in burns.


"Button" skin repair of an ear defect.

"Button" skin repair of an ear defect.


[V. Monaldi (1899-1969)].

[V. Monaldi (1899-1969)].


Virus-like particles in brain tissue from two patients with Creutzfeldt-Jakob disease.


Cochlear morphology in a strain of the waltzing guinea pig.


Female strains of Escherichia coli K12 as selective hosts for the isolation of female specific mutants of phage omega II.


Effect of siomycin on protein synthesizing activity of Escherichia coli ribosomes.


Glutamate--a precusor for the naphthalene nucleus of bacterial menaquinones.


Facile assignment of disulfide bonds in proteins through detection of cystine-containing peptides in peptide maps.


The isolation and identification of vibrio cholera--a review.


Quality control in diagnostic microbiology.


Effect of the antitumor antibiotic neocarzinostatin on DNA synthesis in vitro.


Historical population movement and gene flow in Northumberland parishes.


Cineradiographic studies of bolus position during chewing.


Tooth-supported complete dentures.

Tooth-supported complete dentures.


Taking advantage of existing dentures.

Taking advantage of existing dentures.


Plaque formation and the effect of age.

Plaque formation and the effect of age.


Reduction of residual ridges: a major oral disease entity.


Prosthetic restoration in microstomia.

Prosthetic restoration in microstomia.


Incidence of lateral excursions during function with complete dentures.


Obstruction to the renal microcirculation after temporary ischemia.


Gastric ulceration complicating experimental liver transplantation in the pig.


Multiple cranial nerve deficits associated with the Arnold-Chiari malformation.


Successful preservation and simultaneous transplantation of human cadaver kidneys.


Cockpit letters; historical reportage of a physician in Congress.


Research on comparative health service systems.


Immunohistochemical studies on fibrin in vital reactions.


Application of histochemical methods to the study of traffic accidents.


AHA membership.

AHA membership.


Health organizations, agencies, and educational programs.


Guide for hospital buyers.

Guide for hospital buyers.


Action of pepsin on synthetic substrates. I. Hydrolysis and transpeptidation of peptides ranging from glycyl-L-tyrosyl-L-tyrosine to triglycyl-L-tyrosine.


A possible recognition of ribonucleotides by DNA dependent RNA polymerase of E. coli.


Internal standards for molecular weight determinations of proteins by polyacrylamide gel electrophoresis. Applications to envelope proteins of Escherichia coli.


The deoxyribonuclease induced after infection of Escherichia coli by bacteriophage T5. II. Role of the enzyme in replication of the pahge deoxyribonucleic acid.


Conditions allowing synthesis of thymidylate synthetase at the nonpermissive temperature in a temperature-sensitive thy mutant normally blocked in its translation.


A consequence of the rel gene during a glucose to lactate downshift in Escherichia coli. The rates of ribonucleic acid synthesis.


The pathological anatomy of convex pes valgus.


The early management of varus feet in myelomeningocele.


Talectomy for equinovarus deformity in arthrogryposis and spina bifida.


Destructive joint changes following kidney transplantation. Report of a case.


Thomas Arthur Berry, 1917-1971.

Thomas Arthur Berry, 1917-1971.


The effect of frozen irradiated bone homografts on the healing of defects in the mandible and femur of the rat.


Derek Willey Purser, 1922-1970.

Derek Willey Purser, 1922-1970.


Vernon Stanley Hughes-Davies, 1905-1970.


William Rupert Welply, 1912-1970.

William Rupert Welply, 1912-1970.


Utilization of hydroxymethylpyrimidine phosphates by a mutant strain of Escherichia coli.


Correlation of bruits over the carotid artery with angiographically demonstrated lesions.


Stereotactic thrombosis of intracranial aneurysms.


Quantitative measurements of L-dopa therapy in Parkinson's disease.


A double-blind crossover study of the L-dopa treatment of torsion dystonia in identical twins.


Immunosuppression and the Guillain-Barré syndrome.


Uptake of nonmetabolites by brain slices.


On neural-tube defects: an epidemiological elicitation of etiological factors.


Metabolism and clinical assessment of L-dopa in parkinsonism.


Franz Goldmann, M.D.

Franz Goldmann, M.D.


A subtraction method for determining cerebral blood flow by xenon-133 inhalation.


Effects of corticosteroids on corneal thickness following penetrating keratoplasty.


Hippus. Semantic and historic considerations of the word.


Ultrastructural studies of the blood-aqueous barrier. I. Transport of an electron-dense tracer in the iris and ciliary body of the mouse.


Corneal intrastromal cyst.

Corneal intrastromal cyst.


Epithelial swelling with oxygen insufficiency.


Historical review of oculogenital disease.


Ernesto Trucco, April 10, 1922--August, 1970.


Admiral Horatio Nelson's combined knife and fork.


Historical evaluation of concepts concerning A-V conduction.


Autoimmune heart disease.

Autoimmune heart disease.


Acute hemodynamic effects of dopamine in patients with shock.


Measurement of coronary sinus blood flow by continuous thermodilution in man.


Fine structure of the His bundle.

Fine structure of the His bundle.


Pattern classification of renal electrolyte cycles in primary aldosteronism.


Computer program for diagnostic evaluation of electrocardiograms.


Trapping of blood lymphocytes on glass bead columns coated by autologous thymus and lymph node extract.


Oral status of edentulous and complete denture-wearing patients.


Total body potassium changes during lithium administration.


The hospitalization proneness scale as a predictor of response to phenothiazine treatment. II. Delay of psychiatric hospitalization.


Modifications to the Hughes bacteria press to avoid damage to the press which occurs during normal use.


Immunopathological studies of parabiosis in adult mice.


Electron-microscopic studies of dried and rehydrated frog muscles.


The development of electron microscopy in the biological sciences in Poland in the past 25 years.


Historic trends in deaths from chronic kidney disease in the United States and Britain.


Oral vaccination of foxes against rabies.


Hemorrhagic and endotoxic shock: a pathophysiologic approach to diagnosis and management.


Infant resuscitation and prevention of mental retardation.


Classic pages in obstetrics and gynecology. A Döderlein and B. Krönig. Operative Gynäkologie (3rd edition). Leipzig, G. Thieme, 1912.


Intravenous radioisotope angiography with computer processing of data.


Spatial statistics of a gamma camera.

Spatial statistics of a gamma camera.


The American Journal of Roentgenology Radium Therapy and Nuclear Medicine.


Harry Hauser, M.D. 1904-1971.

Harry Hauser, M.D. 1904-1971.


Recurrent inguinal hernia.

Recurrent inguinal hernia.


Pancreas transplantation in man. I. The donor and recipient operation.


Circulatory arrest during profound hypothermia. For treatment of complicated disease of major vessels.


Comparative evaluation of ligation and partial interruption of the inferior vena cava.


Experience with subtotal parathyroidectomy for "tertiary" hyperparathyroidism.


Improved management of neonates with congenital diaphragmatic hernias.


Goodpasture's syndrome. Treatment with nephrectomy and renal transplantation.


Aminoacyl nucleosides derived from the tumour inhibitor, 1-aminocyclopentanecarboxylic acid.


l-asparaginase resistance in human leukemia--asparagine synthetase.


Iodination of nucleic acids in vitro.

Iodination of nucleic acids in vitro.


2'-O-methyladenosine 5'-triphosphate. A substrate for deoxyribonucleic acid dependent ribonucleic acid polymerase of Pseudomonas putida.


Effects of macrolides on peptide-bond formation and translocation.


Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with carbamyl phosphate.


Modification of responsiveness to allografts in larvae of the leopard frog by thymectomy.


The pathogenesis of spina bifida: a study of the relationship between observation, hypothesis, and surgical incentive.


Ambrose Birmingham (1864-1905).

Ambrose Birmingham (1864-1905).


[V. A. Novachkov (on his 60th birthday)].


Léon Bernard Foundation Award.

Léon Bernard Foundation Award.


Shousha Foundation Award.

Shousha Foundation Award.


Darling Foundation Award.

Darling Foundation Award.


Significance of imprint smear in cytologic diagnosis of malignant tumors of the stomach.


Immunocytology of cancer.

Immunocytology of cancer.


Cytology of malignant lymphomas of the stomach.


Neonatal congenital syphilis. Diagnosis by the anti IgM treponemal fluorescence test.


Cell recognition by neighborhood grouping techniques in TICAS.


Quick drying mounting fluid.

Quick drying mounting fluid.


Effect of human chorionic gonadotropin on intrauterine skin allograft survival in rats.


Histochemical localization of lactate dehydrogenase isoenzymes in the human placenta.


Radiosensitivity of mammalian oocytes with particular reference to the human female.


The plans and purposes of the American Public Health Association.


Prevention of dissipation of health services resources.


Attenuated rubella vaccine (HPV-77): evaluation in a large controlled trial.


Public health: then and now. The first neighborhood health center movement--its rise and fall.


Penicillin-historical impact on infection control.


The chemistry of synthetic and semisynthetic penicillins.


Treatment of pneumonia in adults with hetacillin.


Laboratory determination of antibiotic susceptibility to ampicillin and cephalothin.


Broad-spectrum penicillins in enteric infections of children.


Fragmented E. coli methionine tRNA f  as methyl acceptor for rat liver tRNA methylase: alteration of the site of methylation by the conformational change of tRNA structure resulting from fragmentation.


The effect of a reporter molecule on chromatin template activity.


Phage-induced radioresistance of lysogenic bacteria.


In vitro O 2 '-methylation of sugars in E. coli RNA. 3. Methylation of E. coli transfer RNA by heterologous methylases in particulate-free extracts of wheat embryo.


Satellite association in human lymphocytes and sodium citrate concentration of hypotonic (spreading) solution.


Cytogenetics of a univalent chromosome in B s  drosophila melanogaster males.


Skin avulsion of the thumb. (Case P69).

Skin avulsion of the thumb. (Case P69).


Diabetes and the fetus: questions which need answers.


Thymidine phosphorylase from Escherichia coli. Properties and kinetics.


Immunochemistry of K antigens of Escherichia coli. The K29 antigen of E. coli 09:K29(A):H-.


The vitamin B12-dependent methionine synthetase. The cycle of transmethylation.


Influence of netropsin and distamycin A on the secondary structure and template activity of DNA.


Cellular localization of group I pepsinogens in human gastric mucosa by immunofluorescence.


Bile acid inhibition of the intestinal microflora--a function for simple bile acids?


Gastric mucosal barrier.

Gastric mucosal barrier.


Experimental production of pyeloureteritis cystica and glandularis.


A backward glance at the study of postmortem anatomy. I.


In vivo antibacterial activity of diaveridine-sulfonamide combinations.


Renal blood flow changes posttransplantation: renal denervation versus renal ischemia.


Renal lactate and pyruvate metabolism in dogs after graded renal ischemia.


Alloplastic replacement of the partially resected urethra on dogs.


Sir Humphry Davy (1778-1829).

Sir Humphry Davy (1778-1829).


Albert Claude and the beginnings of biological electron microscopy.


On the "energized-twisted" configuration of isolated beef heart mitochondria.


A preliminary study of the treponemal pallidum haemagglutination test (TPHA).


A case of reticulum cell sarcoma of the larynx.


Myocardial energetics: basic principles and clinical implications.


Calories, growth and the quality of life.


Failure of isoprinosine in amyotrophic lateral sclerosis.


Committee and commission appointments of the North Carolina State Medical Society.


Medicaid administrative controls.

Medicaid administrative controls.


Nutritional effects on polyribosome distribution and protein synthesis in cultured cells.


"Overnutrition" and brain function.

"Overnutrition" and brain function.


Intra-uterine undernutrition and brain development.


Effect of rifampicin on stability and transfer of R-factors.


The host-parasite relationships of plant-parasitic nematodes.


The epidemiology and control of some nematode infections of grazing animals.


Meteorological factors and forecasts of helminthic disease.


Paragonimus and paragonimiasis.

Paragonimus and paragonimiasis.


Experimental fascioliasis in Australia.

Experimental fascioliasis in Australia.


Timely topics in clinical chemistry 1970, a review.


[Death of Mr. Raymond Garcin].

[Death of Mr. Raymond Garcin].


The classification of some oral streptococci of human or rat origin.


Aztec medicine with comments on Mexican neurosurgery.


ULF ballistocardiography in human cardiac transplantation.


The sequence of nucleotides in tRNA Ile  from E. coli B.


Genetic and physiological studies of bacteriophage T5. 2. The relationship between phage DNA synthesis and protein synthesis in T5-infected cells.


Cross-linking of Salmonella isopropylmalate synthesis with dimethyl suberimidate: evidence for antagonistic effects of leucine and acetyl-CoA on the guaternary structure.


Protein synthesis in rabbit reticulocytes: factors controlling terminal and internal methionine codon (AUG) recognition by methionyl tRNA species.


Complex formation between transfer RNA'S with complementary anticodons.


Binding of the termination factor rho to DNA.


Renicolid trematodes (digenea) from the renal tubules of birds.


The coding nature of valyl-transfer RNA binding to ribosomes during methionine starvation in E. coli 113-3.


Enzyme induction in the presence of rifampin, an inhibitor of the transcription process.


Production of pyrimidine dimers in DNA in the dark.


Chemical evidence showing involvement of sulfhydryl groups in protein synthesis with E. coli system.


Phenanthrene bound to a protein by biosynthesis.


Incorporation of methionine from met-tRNA-Met-F into internal positions of polypeptides by mouse liver polysomes.


Inhibition of polynucleotide kinase by agar, dextran sulfate and other polysaccharide sulfates.


Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.


Synthesis and use of 1-O- -D-galactopyranosyl-D-mannitol as source of D-mannitol for Escherichia coli.


Nuclease action on Escherichia coli ribosomes and its application to sequence studies on ribosomal ribonucleic acid.


Role of molecular conformation in determining the electrophoretic properties of polynucleotides in agarose-acrylamide composite gels.


Fractionation of the nonpolar transfer ribonucleic acids from rat liver, yeast, and Escherichia coli by partition chromatography.


New knowledge about HGH.

New knowledge about HGH.


Changing concepts on the control of growth hormone secretion in man. New facts have emerged about growth hormone (hgh) secretion in man giving rise to new conceptions and to new questions.* In well-nourished, lean human beings growth hormone is released in early deep sleep and the pattern of release observed from night to night is fairly constant.* The release of growth hormone in sleep occurs when plasma glucose is not fluctuating and after insulin has fallen to a very low level. Plasma-free fatty acids may rise about two hours later but insulin does not rise in response to nocturnal hgh release.* The releases of growth hormone in sleep appear to meet the needs for a physiological test for the study of problems of growth. Correlations of this test with the many pharmacologic maneuvers in current use for diagnosis remain to be made.* Growth hormone secretion as judged by plasma concentrations relates to protein intake, such that protein depletion initiates compensatory elevation of plasma concentrations of growth hormone. Further elevations may occur with glucose loading-so-called "paradoxical" responses. In contrast, there is compensatory suppression of growth hormone secretion in obesity. Repletion of protein in the malnourished and reduction of weight in obesity cause return toward normal secretion of hgh.* Levodopa as a possible specific stimulus to growth hormone release has just been reported and the implications of this finding for the child of short stature cannot yet be assessed.


Norma Ford Walker 1893-1968.

Norma Ford Walker 1893-1968.


History of the exposure of miners to radon.


Precursor ribosomal ribonucleic acid and ribosome accumulation in vivo during the recovery of Salmonella typhimurium from thermal injury. When cells of S. typhimurium were heated at 48 C for 30 min in phosphate buffer (pH 6.0), they became sensitive to Levine Eosin Methylene Blue Agar containing 2% NaCl (EMB-NaCl). The inoculation of injured cells into fresh growth medium supported the return of their normal tolerance to EMB-NaCl within 6 hr. The fractionation of ribosomal ribonucleic acid (rRNA) from unheated and heat-injured cells by polyacrylamide gel electrophoresis demonstrated that after injury the 16S RNA species was totally degraded and the 23S RNA was partially degraded. Sucrose gradient analysis demonstrated that after injury the 30S ribosomal subunit was totally destroyed and the sedimentation coefficient of the 50S particle was decreased to 47S. During the recovery of cells from thermal injury, four species of rRNA accumulated which were demonstrated to have the following sedimentation coefficients: 16, 17, 23, and 24S. Under identical recovery conditions, 22, 26, and 28S precursors of the 30S ribosomal subunit and 31 and 48S precursors of the 50S ribosomal subunit accumulated along with both the 30 and 50S mature particles. The addition of chloramphenicol to the recovery medium inhibited both the maturation of 17S RNA and the production of mature 30S ribosomal subunits, but permitted the accumulation of a single 22S precursor particle. Chloramphenicol did not affect either the maturation of 24S RNA or the mechanism of formation of 50S ribosomal subunits during recovery. Very little old ribosomal protein was associated with the new rRNA synthesized during recovery. New ribosomal proteins were synthesized during recovery and they were found associated with the new rRNA in ribosomal particles. The rate-limiting step in the recovery of S. typhimurium from thermal injury was in the maturation of the newly synthesized rRNA.


Boticinogeny and actions of the bacteriocin. The bacteriocin, boticin E, was produced by only a few strains of those clostridia which are nontoxigenic but otherwise identical to Clostridium botulinum type E. Boticin preparations from four different strains had identical spectra against indicator cultures. Experiments with bacterial lawns showed boticin to be sporostatic for all tested nonproteolytic C. botulinum (types B, E, and F) and nontoxigenic type E-related strains which included the producing strains as well as those different from type E in the fermentation of one to three carbohydrates. Boticin had no detectable effect on vegetative cells of boticinogenic strains but killed those of all other strains whose spores were sensitive. Cultures that were growing in an agar medium were more sensitive to the bacteriocin than those growing in broth. Vegetative cells of indicator strains adsorbed boticin, but cells of a boticin-resistant mutant did not. Boticin did not lyse suspensions of vegetative cells which had been killed previously by exposure to air but lysed actively growing protoplasts and L-forms of a strain whose normal vegetative cells are susceptible to lysis. Sporostasis resulted from inhibition of germination rather than of outgrowth. Proteolytic strains of C. botulinum (types A, B, and F) were resistant to boticin E.


Properties of a Salmonella typhimurium mutant with an incomplete deficiency of uridinediphosphogalactose-4-epimerase. A galactose-negative mutant, nonleaky in respect to fermentation and utilization, isolated from a smooth Salmonella typhimurium strain by phage selection and inferred deficient of uridine diphosphate (UDP)-galactose-epimerase, was used for experiments on relation of somatic lipopolysaccharide (LPS) character to virulence. Extracts of induced mutant cells retained ca. 1% of wild-type epimerase activity and had only ca. 5% of wild-type kinase and uridyl transferase activities; also, some cultural properties of the mutant differed from those of mutants with complete defects of epimerase only. The mutant was not galactose sensitive, presumably because of its kinase defect. Although the mutant had the phage pattern (including C21-sensitivity) of an epimerase mutant, it was susceptible to transduction by phage P22 and was O-agglutinable, even when grown on defined medium; its LPS must therefore contain some O polymer, including endogenous galactose, resulting from residual epimerase activity. Growth on galactose-supplemented medium restored smooth phage sensitivity; since the mutant was partly inducible this may result, at least in part, from increased endogenous production of UDP-galactose. The mutant was made galactose positive by introduction of an F'-gal(+) plasmid. Base-change and frame-shift mutagens did not increase the frequency of reversion above the spontaneous rate. An insertion into the operator-promoter region of the gal operon seems the most likely mechanism of the mutation.


Influence of ribosides on ultraviolet resistance of Escherichia coli: role of deoxyribonucleic acid synthesis in the ultraviolet resistance enhancement after amino acid prestarvation. Changes in the resistance of cells of Escherichia coli B/r Hcr(+)thy(-)trp(-) to ultraviolet radiation were investigated after the following pretreatments: (i) amino acid starvation which, according to previous conclusions, enabled the cells to complete replication cycles of deoxyribonucleic acid (DNA); (ii) amino acid starvation during which the synthesis of DNA was arrested by the addition of 50 mug of cytidine per ml. The results showed that the enhancement of resistance observed after amino acid prestarvation was in correlation with the amount of DNA which was synthesized during the amino acidless period. The enhancement of resistance can be abolished by the addition of the riboside at any phase of the starvation period. This shows that the enhancement of resistance was not a consequence of the total inhibition of metabolism but of unbalanced growth which evoked the completion of replication cycles of DNA.


Characterization of the late steps of microbial heme synthesis: conversion of coproporphyrinogen to protoporphyrin. Cell-free extracts of various cytochrome-containing, heterotrophic microorganisms were examined for ability to convert coproporphyrinogen to protoporphyrin. Extracts of Escherichia coli and Pseudomonas denitrificans readily accumulated large amounts of protoporphyrin when assayed under aerobic conditions. However, protoporphyrin did not accumulate under either aerobic or anaerobic conditions of assay or in the presence of various supplements in extracts of the aerobe Micrococcus lysodeikticus, the facultative anaerobe Staphylococcus aureus, or the anaerobe Vibrio succinogenes. Protoporphyrin also accumulated when extracts of E. coli and P. denitrificans were incubated aerobically with the early heme precursor, delta-amino levulinic acid (ALA). This protoporphyrin accumulation was markedly stimulated by the iron chelator, o-phenanthroline. Extracts of S. aureus and M. lysodeikticus accumulated coproporphyrin, but not protoporphyrin when incubated with ALA. The enzyme system in extracts of E. coli which converts coproporphyrinogen to protoporphyrin under aerobic conditions of assay was also partially characterized. This conversion was stimulated by the iron chelator, o-phenanthroline, the respiratory inhibitor, cyanide, and the reducing agent, thioglycolate. Dialysis of the extract did not diminish enzyme activity. Certain alternate electron acceptors and nitrite caused a marked inhibition of the conversion. These results indicate that this late step in heme synthesis, the conversion of coproporphyrinogen to protoporphyrin, can be readily demonstrated in extracts of some, but not all, cytochrome-containing bacteria and that the aerobic conversion in E. coli exhibits many characteristics similar to those demonstrated for the aerobic conversion previously studied in liver mitochondria.


Effect of nutrient concentration on the growth of Escherichia coli. The relationship between specific growth rate of Escherichia coli and the concentration of limiting nutrient (glucose or phosphate or tryptophan) has been determined for populations in a steady state. At high concentrations the specific growth rate is independent of the concentration of nutrient, but at low concentrations the specific growth rate is a strong function of the nutrient concentration. Such a relationship was predicted by Monod; however, Monod's equation does not predict the relationship over the entire range of nutrient concentration. If parameters of the equation are estimated from the results obtained at low concentrations, then at high concentrations of nutrient, the specific growth rate is significantly higher than that predicted by Monod's equation. These results were interpreted on the basis that the rate of growth is controlled by at least two parallel reactions and that the affinities of the enzymes catalyzing these reactions are different. The relationship between specific growth rate and mean cell volume was also measured, and the results indicate that mean cell volume depends not only on the specific growth rate but also on the nature of the limiting nutrient. There are different mean cell volumes at the same specific growth rate established by different limiting nutrients. Therefore, the mean cell volume is not uniquely determined by the specific growth rate.


Synthesis of ribonucleic acid and protein in plasmid-containing minicells of Escherichia coli K-12. Unlike the deoxyribonucleic acid (DNA)-deficient minicells produced by F(-) parents, minicells produced by plasmid-containing strains contain significant amounts of plasmid DNA. We examined the ability of plasmid-containing minicells to synthesize ribonucleic acid (RNA) and protein. In vivo, minicells produced by F(-) parents are unable to incorporate radioactive precursors into acid-insoluble RNA or protein, whereas minicells produced by F', R(+), or Col(+) parents are capable of such synthesis. Using a variety of approaches, including polyacrylamide gel analysis of the RNA species produced and electron microscope autoradiography, we demonstrated that the synthesis observed in minicell preparations is a property of the plasmid-containing minicells and not a result of the few cells (approximately 1 per 10(6) minicells) contaminating the preparations. That the observed synthesis is of biological importance is suggested by the ability of plasmid-containing minicells to yield viable phage upon infection with T4.


Metabolism of T4 bacteriophage ghost-infected cells: effect of bacteriophage and ghosts on the uptake of carbohydrates in Escherichia coli B. Ghosts of T4 bacteriophage inhibit the uptake of thiomethyl-beta-galactoside (TMG), alpha-methylglucoside, glucose-6-phosphate, and glycerol in Escherichia coli B. The transport of orthonitrophenyl-beta-galactoside (ONPG) is also inhibited to a lesser degree and without alteration of the apparent K(m) of transport. These effects of ghosts parallel those of energy poisons on these systems. However, no one energy poison can produce such pronounced inhibitory effects in all these systems. The effect of the intact phage in these systems was either absent or very slight relative to the ghost. The effect of ghosts on the uptake of TMG was not immediate; at 10 C, no effect of the ghosts was apparent for at least 2 min. This suggests that a step, more temperature dependent than the attachment of the ghost, is necessary for the inhibitory action. The intracellular level of adenosine triphosphate (ATP) in the ghost-infected cells fell to less than 25% of the control value, and the ATP lost from the cell appeared in extracellular medium. Phage, on the other hand, caused no decrease in the intracellular ATP level. This loss of ATP from the cells after ghost infection suggests an alteration of the barrier properties of the membrane so that ATP can leave the cell; however, the accessibility of extracellular ONPG to intracellular beta-galactosidase does not increase. The dissimilarity of the actions of phage and ghosts on all properties examined does not support the model that the initial events in their infections are identical but that the intact phage, unlike the ghost, can provide information for the repair of its effects.


Ribosomal helices: formation in Escherichia coli during acidic growth. Ribosomal helices are formed in 100% of Escherichia coli cells during extended growth in a medium of low buffering capacity. During this time, the pH of the medium gradually decreases from 7.0 to about 5.0. Transfer of cells into preconditioned or acidified medium does not result in helix formation unless acidification is gradual and during active growth. Concomitant with helix formation is a decrease of all major biosynthetic activities and cessation of cell motility. The larger polyribosomes become converted into an inactive helical form and sediment in sucrose gradients with the wall-membrane complex.


Microbial life at 90 C: the sulfur bacteria of Boulder Spring. The physiology of the bacteria living in Boulder Spring (Yellowstone National Park) at 90 to 93 C was studied with radioactive isotope techniques under conditions approximating natural ones. Cover slips were immersed in the spring; after a fairly even, dense coating of bacteria had developed, these cover slips were incubated with radioactive isotopes under various conditions and then counted in a gas flow or liquid scintillation counter. Uptake of labeled compounds was virtually completely inhibited by formaldehyde, hydrochloric acid, and mercuric bichloride, and inhibition was also found with streptomycin and sodium azide. The water of Boulder Spring contains about 3 mug of sulfide per ml. Uptake of labeled compounds occurs only if sulfide or another reduced sulfur compound is present during incubation. The pH optimum for uptake of radioactive compounds by Boulder Spring bacteria is 9.2, a value near that of the natural spring water (8.9). Many experiments with a variety of compounds were performed to determine the temperature optimum for uptake of labeled compounds. The results with all the compounds were generally similar, with broad temperature optima between 80 and 90 C, and with significant uptake in boiling (93 C) but not in superheated water (97 C). The results show that the bacteria of Boulder Spring are able to function at the temperature of their environment, although they function better at temperatures somewhat lower. The fine structure of these bacteria has been studied by allowing bacteria in the spring to colonize glass slides or Mylar strips which were immediately fixed, and the bacteria were then embedded and sectioned. The cell envelope structure of these bacteria is quite different from that of other mesophilic or thermophilic bacteria. There is a very distinct plasma membrane, but no morphologically distinct peptidoglycan layer was seen outside of the plasma membrane. Instead, a rather thick diffuse layer was seen, within which a subunit structure was often distinctly visible, and connections frequently occurred between this outer layer and the plasma membrane. The thick outer layer usually consisted of two parts, the outer part of which was sometimes missing. Within the cells, structures resembling ribosomes were seen, and regions lacking electron density which probably contained deoxyribonucleic acid were also visible.


Taxonomy of marine bacteria: the genus Beneckea. One-hundred-and-forty-five isolates of marine origin were submitted to an extensive physiological, nutritional, and morphological characterization. All strains were gram-negative, facultatively anaerobic, straight or curved rods which were motile by means of flagella. Glucose was fermented with the production of acid but no gas. Sodium but no organic growth factors were required. None of the strains were able to denitrify or fix molecular nitrogen. The results of nutritional and physiological tests were submitted to a numerical analysis. On the basis of phenotypic similarity, nine groups were established. These groups could be distinguished from one another by multiple, unrelated, phenotypic traits. Six groups which had deoxyribonucleic acid (DNA) containing 45 to 48 moles per cent guanine plus cytosine (GC) were assigned to a redefined genus Beneckea. All of the strains in this genus, when grown in liquid medium, had a single, polar flagellum. When grown on a solid medium, many strains had peritrichous flagella. Two groups were similar to previously described species and were designated B. alginolytica and B. natriegens. The remaining four groups were designated B. campbellii, B. neptuna, B. nereida, and B. pelagia. An additional group of phenotypically similar strains having the properties of the genus Beneckea was not included in the numerical analysis. These strains were readily separable from species of this genus and were designated B. parahaemolytica. Of the remaining groups, one was identified as Photobacterium fischeri. The other group (B-2) which had about 41 moles% GC content in its DNA could not be placed into existing genera.


Deoxyribonucleic acid hybridization among strains of lactobacilli. Hybridization of deoxyribonucleic acid (DNA) from Lactobacillus bulgaricus (ATCC 11842) with DNA of L. lactis (ATCC 12315), L. helveticus (ATCC 15009), and L. jugurt (ATCC 521) showed 86.0% reassociation with L. lactis, 4.8% with L. helveticus, and none with L. jugurt.


Polynucleotide sequence relationships among some bacterial plasmids. The deoxyribonucleic acid of F-like plasmids appear to share a high degree of nucleotide similarity with each other but are not highly related to I-like plasmids.


Variation in the proportion of 50S and 30S ribosomal subunits at different growth rates. The ratio of 50S to 30S native ribosomal subunits varies in a systematic way with the growth rate in a 15T(-) strain of Escherichia coli.


Isolation and genetic analysis of a strain of Escherichia coli K-12 with an amber recA mutation. The isolation, properties, and genetic analysis of a strain of Escherichia coli K-12 with an amber recA mutation are described. The experiments demonstrate that the recA product is a protein that is probably not essential for growth.


Ultraviolet- and X-ray-induced responses of a deoxyribonucleic acid polymerase-deficient mutant of Escherichia coli. Escherichia coli K-12, polAl(-) is a mutant strain whose extracts are deficient in Kornberg deoxyribonucleic acid (DNA) polymerase activity. We have compared the mutant and parental strains on the basis of a number of responses to ultraviolet (UV) and X-irradiation. For both types of radiation, the mutant is more sensitive by approximately the same factor as measured by reduction in colony formation, depression of DNA synthesis, and enhancement of DNA degradation. The rate of repair of X-ray-induced single-strand breaks in the mutant is also slower, as is the repair of breaks after excision repair of UV damage. On the other hand, the mutant has a significant capability to reactivate UV-irradiated lambda phage, although it is almost totally deficient in the ability to carry out UV reactivation. The data indicate that the polAl mutation leaves the cells with some ability to perform excision and strand-rejoining repair but that an exonuclease, whose identity remains obscure, is the agent responsible for the extensive breakdown of the DNA in polAl(-) cells after irradiation.


Kinetics of exogenous induction of the hexose-6-phosphate transport system of Escherichia coli. The kinetics of the exogenous induction of the hexose-phosphate transport system by glucose-6-phosphate (G6P) was investigated. The induction of this system by extracellular but not intracellular G6P was confirmed. The differential rate of synthesis was linear, a function of the extracellular concentration of G6P and independent of the previous induction history of the culture. Neither maintenance nor autocatalysis, phenomena described in the induction of the lac operon, were observed in the exogenous induction of hexose-phosphate transport. Fructose-6-phosphate, a potent competitive inhibitor of G6P influx, had no effect on the induction of the system by G6P, indicating that the transport of inducer was not involved in the induction process.


Chromosome replication and the division cycle of Escherichia coli B-r. The average amount of deoxyribonucleic acid (DNA) per cell was measured in steady-state cultures of Escherichia coli B/r grown at 37 C in glucose-limited chemostats or in batch cultures in the exponential growth phase as maintained with one of several carbon sources. Within experimental errors, DNA content was dependent only on growth rate and independent of the type of culture, the carbon source, or the addition of growth factors. The amount of DNA per cell increased continuously with growth rate over the range of 0.02 to 3 divisions per hour. The data over the entire range of growth rates are in agreement with a constant time for a single replication point to traverse the entire genome, 47 min, and with cell division following 25 min after termination of replication. The measured amount of DNA per genome was 4.2 x 10(-15) g (or 2.5 x 10(9) daltons).


D-Fucose as a gratuitous inducer of the L-arabinose operon in strains of Escherichia coli B-r mutant in gene araC. d-Fucose, a nonmetabolizable analogue of l-arabinose, prevents growth of Escherichia coli B/r on a mineral salts medium plus l-arabinose by inhibiting induction of the l-arabinose operon. Mutations giving rise to d-fucose resistance map in gene araC and result in constitutive expression of the l-arabinose operon. Most of these mutations also permit d-fucose to serve as a gratuitous inducer. It is concluded that d-fucose-resistant mutants produce an araC gene product with an altered inducer specificity. Addition of l-arabinose to cells induced with the gratuitous inducer, d-fucose, resulted in severe transient repression of operon expression followed by permanent catabolite repression. Transient repression but no permanent catabolite repression was obtained when cells unable to metabolize l-arabinose were employed. It is concluded that transport of l-arabinose alone is sufficient to achieve transient repression of its own operon, but that metabolism of l-arabinose must occur to achieve permanent catabolite repression of the l-arabinose operon. This general effect has been termed "self-catabolite repression."


Analysis of sodium transport in the amphibian oocyte by extractive and radioautographic techniques. The transport of Na(+) in mature Eurycea oocytes was studied by quantitative radioautography of (22)Na(+) using techniques suitable for localization of diffusible solutes, together with conventional extractive techniques. Intracellular Na(+) consisted of three kinetic fractions: a cytoplasmic fast fraction of about 8.5 microeq/ml H(2)O; a cytoplasmic slow fraction of about 58.7 microeq/ml H(2)O; and a nuclear fast fraction of about 11.1 microeq/ml H(2)O. A nuclear slow fraction, if it exists, does not exceed 5% of the cytoplasmic. The fast fractions represent freely diffusible Na(+) in the two compartments; the nuclear solvent space is 1.3 times the cytoplasmic. The flux of both fast fractions is determined by the permeability of the cortical membrane, with neither the nuclear membrane nor diffusion in the cytoplasm detectably slowing the flux. The cytoplasmic slow fraction is interpreted to represent Na(+) bound to nondiffusible constituents which are excluded from the nucleus; these may be yolk platelets, although the widespread observation of Na(+) binding in other cells, and the high Na(+)/K(+) selectivity, argues against simple ion-binding to the yolk phosphoprotein.


New observations on flagellar fine structure. The relationship between matrix structure and the microtubule component of the axoneme. The sperm flagella of the blowfly Sarcophaga bullata demonstrate the relationship of radial projections in the matrix region to the microtubule organization of the axoneme. The A microtubule of each peripheral doublet is connected to the central sheath by a series of paired radial links. The links lie along the tubule wall with a alternate spacing of about 320/560 A. The distal end of each link is enlarged into a globular head that connects via a transitional link to the helical sheath around the central microtubules. The radial link pairs are disposed in the form of a double helix with a pitch of about 1760 A. It is proposed that a similar organization is common to all cilia and flagella showing ninefold symmetry and must provide, in part, the morphological basis for motility.


A fine structural study of adhesive cell junctions in heterotypic cell aggregates. Mixed suspensions of cells obtained by dissociation of 7 day chicken embryo heart and pigmented retina were allowed to reaggregate in tissue culture. The reaggregates which resulted contained both kinds of cells. Establishment of homogeneous tissues by cell sorting out in these reaggregates was advanced by 20 hr in culture and was complete within 2 days. When sorting out was advanced, heterotypic aggregates were fixed, sectioned, and examined in the electron microscope. Particular attention was paid to the morphology of regions of contact between cells. No qualitative differences were observed in the contact junctions between like cells (heart-heart or pigmented retina-pigment retina junctions) and unlike cells (heart-pigmented retina junctions). Broad areas of undifferentiated cell contact with cell membranes separated by a 100-200 A gap were formed regardless of cell type. Specialized junctions of the fascia and macula adherens type were also present, not only between like cells but also between unlike cells.


An interpretation of liver cell membrane and junction structure based on observation of freeze-fracture replicas of both sides of the fracture. A modification of the freeze-fracturing technique to permit observation of replicas of both sides of the fracture is described. It has been used to study mouse liver cell membrane structure. Membranes break to give two faces with three-dimensional complementarity, although there is some small-scale mismatching which is discussed. Since the two distinctive sets of membrane faces are complementary sets, they cannot be the two outside surfaces. In particular, structures (such as particles) seen on these faces are within the membrane. It is not possible from this work to say precisely where the fracture plane goes with respect to a plasma membrane, only that it must be close to the interface between membrane and cytoplasm, or at that interface. Models, consistent with the appearance of the matching replicas, are derived for three regions of the plasma membrane: (a) The nonjunctional plasma membrane, which contains many scattered particles. Except for these particles, the otherwise flat fracture face is not at variance with a bimolecular leaflet structure. (b) Gap junctions. Each of the two membranes comprising a gap junction contains a close-packed array of particles. (c) Tight junctions. Here membranes have ridges within them.


Cytocheical measurements of  -glucuronidase acivity in normal and inflamed human gingiva.


Electron microscope radioautographic study of glycogen synthesis in the rabbit retina. Glycogen is present in the rabbit retina in monoparticulate form. Beta particles ( approximately 229 A) are abundant in Müller cell cytoplasm, particularly in its inner portion, decreasing in number outwards along the cell. They are slightly larger ( approximately 250 A) and much scarcer in neurons, though regularly present in the juxtanuclear Golgi region of ganglion cells. When the retina was incubated in a glucose-free medium, it was rapidly depleted of native glycogen. On further incubation in medium containing glucose-(3)H plus unlabeled glucose, glycogen reappeared in the form of beta particles of the same size and distribution as native ones, while radioautography revealed the appearance of amylase-labile radioactivity in the same locations. This newly formed glycogen was not associated with any particular organelle. The rate of synthesis, as judged from the amount of radioactivity, was high in the inner portion of Müller cells and declined uniformly toward the cell outer end, following a logarithmic gradient. The rate of synthesis was low in ganglion cells, at best approaching values in the outer portion of Müller cells. The concentration of glycogen in the inner portion of Müller cells is consistent with the view that it may be the source of glucose for the anaerobic glycolysis prevailing in the inner retina.


Subpopulations of blood lymphocytes demonstrated by quantitative cytochemistry.


Inhibition of renal acid phosphatase and aryl sulfatase activity by glutaraldehyde fixation.


An unusual lesion in the pig aorta.

An unusual lesion in the pig aorta.


Surgical techniques in the study of canine fetal physiology.


Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. IV. A preliminary report on phenoformin results.


Surgical repair of complete acromioclavicular separation.


E coli otitis media.

E coli otitis media.


Replication of the F'lac sex factor in the cell cycle of Escherichia coli.


The function of the  -factor of Escherichia coli RNA polymerase in template site selection.


A microbial assay for detecting chemical mutagens in tissue homogenates.


Occurrence of aflatoxin producing strains of Aspergillus flavus Link in stored corn.


Immunosuppressive treatment of proliferative glomerulonephritis.


Prevention of postoperative venous thrombosis.


Rhinosporidiosis in Iran (Persia)--a study of seventy-four cases.


Immunofluorescent tests in the course of  99m Tc scintiscanning procedures in children and adolescents.


A case report of Nocardia asteroides of the eye.


Chlamydospore induction in pure culture in Fusarium solani.


Exhibition at the Science Museum.

Exhibition at the Science Museum.


C1 inhibitor: evidence for decreased hepatic synthesis in hereditary angioneurotic edema. Although the Cl inhibitor was detected in 5 to 10 percent of normal hepatic parenchymal cells by means of the immunofluorescent technique, none was seen in liver biopsies from two individuals with hereditary angioneurotic edema having low concentrations of Cl inhibitor in the serum. In contrast, the percentages of cells which reacted with fluorescent antiserums to C4 and transferrin were normal. These data suggest that in most subjects with hereditary angioneurotic edema, there is decreased synthesis of the C1 inhibitor but normal synthesis of C4, and that the disease results from this biosynthetic error.


A study of the effect of Ascoxal chewing tablets (Ascoxal T R ) on dental calculus deposits and on the oral mucosa after gingivectomy.


Decomposition of pectin in vitro by pure strains of rumen bacteria.


Reliability of bacteriologic identification of  -hemolytic streptococci in private offices.


Bacterial flora of udder and the number of cellular elements in milk.


Chronic nonhereditary blistering disease in children: immunofluorescent studies.


Uremic cardiac tamponade in children.

Uremic cardiac tamponade in children.


Segregation of phage receptors T 6 during cell division in Escherichia coli K 12.


The diagnosis of human African trypanosomiasis (T. gambiense) by the use of fluorescent antibody test. I. Standardization of an easy technique to be used in mass surveys.


Infectious disease problems of narcotic addicts.


Degradation of Escherichia coli polynucleotide phosphorylase by E. coli endogenous proteases and by trypsin.


Biosynthesis of ribosomes in E. coli. I. Properties of ribosomal precursor particles and their RNA components.


The pattern of potassium liberation following a single dose of suxamethonium in normal and uraemic rats.


Latta--pioneer in saline infusion.

Latta--pioneer in saline infusion.


Application of an end-expiratory pressure in the management of three cases of pulmonary oedema.


Perforation of the right innominate vein by central venous polyethylene catheter.


Unilateral pulmonary oedema following aorta to right pulmonary artery anastomosis (Waterston's operation). Case report.


The protective effect of immunization in experimental E. coli pyelonephritis.


Synthesis of nucleic acids associated with a DNA-containing body in oocytes of Acheta.


Protein synthesis in sterile chloroplasts from Lemna minor L.


The influence of the bone marrow on the repopulation of the thymus in x-irradiated mice.


The mitotic apparatus of a giant ameba: solubility properties and induction of elongation.


Interpretation of surface structures in frozen-etched protoplasts of yeasts.


Tight junctions between contact-inhibited cells in vitro.


Improvement of kasugamycin-producing strain by the agar piece method and the prototroph method.


A selective medium for Agrobacterium radiobacter biotype 2.


Fluorescent pseudomonads--a residual component in the soil microflora?


Pseudomonas fluorescens biotype G, the dominant fluorescent pseudomonad in South Australian soils and wheat rhizospheres.


Introduction of gentamicin. Laboratory and clinical trials.


The growth of cartilage cells in soft agar and liquid suspension.


The intracellular localization of inorganic cations with potassium pyroantimonate. Electron microscope and microprobe analysis. Potassium pyroantimonate, when used as fixative (saturated or half-saturated, without addition of any conventional fixative) has been demonstrated to produce intracellular precipitates of the insoluble salts of calcium, magnesium, and sodium and to preserve the general cell morphology. In both animal and plant tissues, the electron-opaque antimonate precipitates were found deposited in the nucleus-as well as within the nucleolus-and in the cytoplasm, largely at the site of the ribonucleoprotein particles; the condensed chromatin appeared relatively free of precipitates. The inorganic cations are probably in a loosely bound state since they are not retained by conventional fixatives. The implications of this inorganic cation distribution in the intact cell are discussed in connection with their anionic counterparts, i.e., complexing of cations by fixed anionic charges and the coexistence of a large pool of inorganic orthophosphate anions in the nucleus and nucleolus.


The clinical and metabolic effects of porcine calcitonin on Paget's disease of bone. The clinical and metabolic effects of porcine calcitonin were assessed in six patients with Paget's disease and two patients with osteoporosis under metabolic balance conditions. The administration of calcitonin for 4-17 wk resulted in an amelioration of the clinical phenomena associated with Paget's disease, including bone pain, increased skeletal vascularity, congestive heart failure, and neurologic deficits secondary to skeletal impingement. The major metabolic effects of calcitonin in Paget's disease included the induction of positive calcium balance of +50 to +240 mg/day, reduction in hyperphosphatasia and hydroxyprolinuria of 15 to 60%, and a deceleration of radiocalcium turnover by 12 to 46%. Natriuresis, phosphaturia, and reduced urinary calcium excretion were observed, whereas sustained hypocalcemia and hypophosphatemia did not occur. The administration of porcine calcitonin was not associated with adverse objective or subjective reactions, toxic effects, or allergic phenomena. There was no evidence of antibody formation or loss of therapeutic potency. Although the response of individual patients with Paget's disease varied widely, the data indicate that calcitonin, presumably through its skeletal anti-resorptive action, is able to reduce skeletal turnover and volume in Paget's disease, and thereby improve the associated clinical and metabolic abnormalities. Long term therapeutic studies in progress suggest that prolonged periods of control of the generalized condition may be feasible. In osteoporosis, neither clinical improvement nor consistent metabolic changes indicative of amelioration of the skeletal disease were observed.


The effect of experimental insulin deficiency on glucagon secretion. Suppression of pancreatic glucagon secretion by hyperglycemia is a characteristic of normal alpha cell function. However, in diabetic subjects, plasma glucagon is normal or high despite hyperglycemia. It seemed possible that the presence of glucose or its metabolites within the alpha cell might be essential for suppression of glucagon secretion, and that in diabetes an intracellular deficiency of glucose secondary to insulin lack might be responsible for the nonsuppressibility. The present study was designed to determine the effect upon glucagon secretion of blockade of glucose metabolism and of experimental insulin deficiency. Blockade of glucose metabolism was induced in dogs by administration of 2-deoxyglucose or mannoheptulose. A striking rise in glucagon was observed despite accompanying hyperglycemia and hyperinsulinemia, which, in the case of mannoheptulose, was induced by infusing crystalline insulin. To determine if insulin lack also causes paradoxical hyperglucagonemia, dogs were made severely diabetic by alloxan. Fasting glucagon levels ranged from 3 to 22 times normal despite severe hyperglycemia, and were quickly restored to normal by infusing insulin. Diabetes induced in rats by anti-insulin serum was also associated with significant elevation in plasma glucagon. However, diazoxide-induced insulin lack did not increase glucagon in dogs. It is concluded that normal suppression of glucagon secretion by hyperglycemia does not occur when glucose metabolism is blocked or when severe insulin deficiency is produced. It is suggested that normal glucose metabolism within the alpha cell may be an insulin-requiring process without which hyperglycemic suppression of glucagon release cannot occur.


Synthesis of the major bacteriophage fl coat protein. A method which allows one to follow the synthesis of the major f1 coat protein in normal, unirradiated f1-infected cells is reported. The N-terminal tryptic peptide of this protein, labeled with (14)C-lysine, has a negative charge at pH 4.5 and is readily separated from the contaminating peptides of host cell proteins. This technique was used to study several aspects of the synthesis of the major f1 coat protein in infected cells.


Mass spectrometry in the detemination of structure of certain natural products containing sugars.


Isoelectric focusing in pH gradients--a technique for fractionation and characterization of ampholytes.


The determination of carbohydrate in biological materials by gas-liquid chromatography.


Activation analysis of the biological trace elements.


Polarography of proteins, analytical principles and applications in biological and clinical chemistry.


Temperature-sensitive initiation of DNA replication in a mutant of Escherichia coli K12.


Conjugal transfer of UV-damaged F-prime sex factors and indirect induction of prophage- .


Isolation of catenated forms of R factor DNA from minicells.


The permeability of mammalian urinary bladder epithelium.


Recent advances in the ultrastructure of malignant melanoma.


Immunological deficiency syndrome in non-identical twins: maintenance in a gnotobiotic state and attempts at treatment with transplants of bone marrow and foetal thymus.


The uniqueness of human milk. An overview.


The uniqueness of human milk. Introduction.


The uniqueness of human milk. Biochemical aspects.


The uniqueness of human milk. Mammary effects.


The convenience of breast feeding.

The convenience of breast feeding. Immediately after delivery when the baby is put to breast, the simplicity of breast feeding becomes apparent.  There is no concern about the milk not agreeing with the baby, and if he is kept with his mother so she can feed him on demand, the baby will probably gain more weight than if he were on formula.  The mother's milk is always right and is always there.  Traveling is convenient if clothes are worn that make discreet nursing possible; a 2-piece outfit such as a blouse and a skirt works well.  A rest room or a dressing room can also be used for nursing privacy.  A diaper or little blanket thrown over the baby can be a casual cover-up if needed.  The nursing mother has no bottles to carry around and no fears of running out of supplies.  A study by Spock found that mothers of twins who were breast feeding were better organized than those who were bottle feeding.  Although the breast feeding mother is tied down to being a mother of her baby, she grows in discovery of her importance to her baby.  Weaning is a gradual process.  As the baby nurses less, the mother's milk supply decreases.  Even after a baby has been weaned, he might need an occasional nursing to assuage a trying experience like a bump or an illness.


R-B enteric differential system for identification of Enterobacteriaceae. The R/B Enteric Differential System for identifying enteric bacteria has been evaluated with 451 "unknown" cultures from the stock culture collection of the Center for Disease Control. An average of 89.6% of these cultures were correctly identified by the R/B system, when used as recommended by the manufacturer but without the assistance of serology. This percentage ranged, however, from 47% for Klebsiella to 100% for Serratia and Providencia. Of 11 groups or genera of Enterobacteriaceae tested, only three (Enterobacter, Serratia, and Providencia) were identified with 95% or better accuracy. Four groups (Arizona, Citrobacter, Escherichia, and Salmonella) attained 90 to 95% accuracy of identification, and three groups (Edwardsiella, Proteus, and Shigella) scored between 85 and 90% accuracy. We recommend the R/B system as a screening device which is reasonably successful in grouping bacteria but not as a substitute for more exacting conventional procedures.


Accumulation and elimination of coliphage S-13 by the hard clam, Mercenaria mercenaria. Accumulation and elimination of viral particles by hard clams, Mercenaria mercenaria, were studied with the coliphage S-13 as a working model. Escherichia coli uptake and elimination were simultaneously monitored. Clams were exposed to low levels of S-13 (7 particles/ml) in running seawater for several days, achieving titers in tissues from 2 to more than 1,000 times the levels to which they had been exposed. Bacterial accumulation (previously established by other workers) was comparable. Upon exposure to virus-free running water, clams polluted to relatively low levels (100 plaque-forming units/ml) eliminated most of their bacterial contaminants in 24 to 48 hr. Viral contaminants, however, persisted for several days to weeks even under ideal conditions for clam activity, provided that the temperature remained below the inactivation threshold for the virus. Most of the accumulated virus appeared to be sequestered in the digestive gland. These sequestered particles are refractory to those mechanisms responsible for elimination of bacterial contaminants. This discrepancy points out the need for caution in evaluating the efficiency of shellfish depuration processes, especially if only a bacterial criterion is used as a monitoring system.


Improved isolation of anaerobic bacteria from the gingival crevice area of man. A roll tube technique (Hungate method) was employed in an attempt to cultivate a maximal portion of the organisms in the gingival crevice area of man. This technique achieves an anaerobic state by flushing the local environment with oxygen-free gas. Once collected, the crevicular debris was immediately placed into sterile oxygen-free test tubes which were flushed out by the oxygen-free gas. In this manner, the samples were weighed, dispersed, diluted, and cultured in roll tubes and plates. The medium for control (Brewer Jar technique) and Hungate techniques was Heart Infusion Agar fortified with 10% defibrinated horse blood. When the Hungate technique was used, the recovery of viable bacteria, as a percentage of the direct microscopic count, was significantly greater than plates incubated aerobically or utilizing the Brewer Anaerobic technique. Cultural counts by using the Hungate method averaged 41.3% for six samples when 90% nitrogen and 10% hydrogen were used, 70.4% for eight samples when 85% nitrogen, 10% hydrogen, and 5% carbon dioxide were used, and 63.4% for eight samples when 100% carbon dioxide was the gaseous atmosphere. At no time were cultural counts, by using anaerobic plates (Brewer Jar), more than 24% of the direct microscopic count. This suggests that exclusion of oxygen and the presence of carbon dioxide maximized recovery of gingival crevice bacteria.


Simplified method of anaerobic incubation. A method is described that obviates the need for vacuum and tanks of gas mixtures for anaerobiosis in the anaerobic incubator.


Installation and use of the microscope within a gastight glove box. The adaptation of a high-resolution phase-contrast microscope for glove box use, which allows the stage and focusing knobs in the glovebox, although oculars and camera remain outside, is described.


Production of anticapsin by Streptomyces griseoplanus. Anticapsin is a new fermentation product which inhibits formation of the hyaluronic acid capsule of Streptococcus pyogenes. Production of this metabolite in a complex medium by S. griseoplanus is enhanced by high levels of carbohydrate. A number of carbon sources support biosynthesis but sucrose is most effective, the optimum level being 150 g/liter. Neither glucose nor fructose, alone or in combination, serves as an equivalent substitute for sucrose. The addition of dibasic potassium phosphate to the medium further increases anticapsin production. Dissolved oxygen levels are important for synthesis and stability of the metabolite. Anticapsular activity diminishes rapidly in previously aerated broths which are held under static conditions. This decrease does not occur in pasteurized broths or unpasteurized filtrates.


Practical substitution for the indol, methyl red, Voges-Proskauer, citrate system. A substitution for the indole, methyl red, Voges-Proskauer, citrate system is proposed. The scheme employs indole and ampicillin susceptibility tests routinely and uses selectively three other media for six reactions.


A trial of chlormezanone, a non-hormonal tranquilizer, for inhibition of postpartum lactation.


Simplified limbal approach in squint surgery.


Scurvy as an occupational disease. 3 Scurvy during the early global circumnavigations.


Blood factor XIII deficiency: review of literature and report of case.


Renal transplantation in children with corrected abnormalities of the lower urinary tract.


Ureteral sciatic hernias: case report of an infant with bilateral ureteral herniation into the sciatic foramina.


New technique of bivalve nephrolithotomy.


Isolated neurogenic dysfunction of the bladder in children with urinary tract infection.


Simple operative repair of ureterocele (ureterocelorrhaphy).


Perineal uretero-ileostomy: a technique of urinary diversion by which the patient is continent.


Urothelial micro-contour. 3. Mucosal alteration by infection.


Carcinoma of the prostate. Clinical trial results. The Veterans Administration Co-operative Urological Research Group.


Obituary. John Clifford Bugher (1901-1970).


Induced atrophic gastritis for the treatment of peptic ulcer.


Development of the ocular adrenergic nerve supply in man and guinea-pig.


Effect of fluoxymesterone on erythropoietin activity in chronic renal failure.


Isolation of a strain of Mycobacterium lepraemurium from normal laboratory mice.


The application of computers and mathematical methods to research on the function of the cardio-respiratory system.


Myoglobinemia and myoglobinuria in patients with myositis.


Regulation of catabolic pathways in Pseudomonas.


Earpiece dye dilution technique as a method for evaluation of haemodynamic changes during standardized effort test.


Distribution of the carotid circulation in dog.


Bone cancers induced by  224 Ra (Th X) in children and adults.


Report of the ICRU to the International Executive Committee of the XIIth International Congress of Radiology--Tokyo, 1969.


Tranquillizing action of a crystalline fraction of Paspalum scrobiculatum extract in fourteen psychotic patients.


Mycoplasmas and cell cultures.

Mycoplasmas and cell cultures.


Intravenous regional antibiotic perfusion as prophylaxis against infection in injured hands.


Aggregative behaviour of embryonic chick cells in the presence of antibodies directed against actomyosins.


Freeze-etched pollen walls of Artemisia pycnocephala and Lilium humboldtii.


Pollen-wall proteins: the fate of intine-held antigens on the stigma in compatible and incompatible pollinations of Phalaris tuberosa L.


Identifying characteristics of the haematopoietic precursor cell.


Attention in hyperactive children and the effect of methylphenidate (ritalin).


Production of pneumonia after intransal inoculation of gnotobiotic piglets with three strains of Mycoplasma hyorhinis.


Recent additions to a bibliography on cannabis.


An award for Dr. William McBride.

An award for Dr. William McBride.


Observations on drumhead repair in tympanoplastic surgery.


Award of the A.M.A.'s gold medal to Dr. R.H. Macdonald.


Renal artey stenosis in renal transplantation.


A preliminary report on the use of the depot sulphone preparation acedapsone ("Hansolar") in the control of leprosy.


Liver transplantation at King's College Hospital, London.


Physiotherapy following hepatic transplant.


The development of first aid.

The development of first aid.


Cold therapy in the treatment of pressure sores.


The effect of stimulant drugs on human figure drawings in children with minimal brain dysfunction.


Consultation research in mental health and related fields; a critical review of the literature.


Parotid duct fistula: a review.

Parotid duct fistula: a review.


Indications for parathyroidectomy in advanced renal disease.


Stereotaxic realignment of the dislocated cervical spine.


Interdigital neuroma of the foot.

Interdigital neuroma of the foot.


Surgical techniques using the bovine arterial graft.


Repair of common bile duct injury.

Repair of common bile duct injury.


The assassination of Reinhard Heydrich.

The assassination of Reinhard Heydrich.


Immunologic aspects of cancer.

Immunologic aspects of cancer.


Serologic diagnosis by immunofluorescence in experiemental trichinosis and leishmaniasis. The immunofluorescence test in trichinelosis and leishmaniasis with blood collected on filter paper.


Individual dietary surveys: purposes and methods.


Thermal processing of foods. A review.

Thermal processing of foods. A review.


Nutritional influences on periodontal disease.


The world protein shortage: prevention and cure.


Reversible and irreversible effects of protein-calorie deficiency on the central nervous system of animals and man.


Nutritive state of the population in Spain.


Estimation of endotoxin-induced increase in resistance by means of Trypanosoma equiperdum growth curves.


Specific oral prevention of infantile gastroenteritis. II. Experiments in infants.


Type distribution of Streptococcus pyogenes in the years 1964-65 and 1968-69.


Right and left ventricular performance in chronic obstructive lung disease.


Hypotensive effects of clonidine and chlorthalidone. Controlled clinical trial of drugs administered singly and in combination.


Attitude clusters in birth control counseling by social workers.


Environmental sampling of selected public health nursing bag contents.


Responses of the ischemic myocardium to allopurinol.


A selected public health bibliography with annotations.


Sweat function in babies with defects of the central nervous system.


Lack of temperature control in infants with abnormalities of central nervous system.


Treatment of terminal renal failure in children by home dialysis and transplantation.


Neonatal assessment of the child with a myelomeningocele.


Cortical hyperostosis. Infantile and juvenile manifestations in a boy.


Oral contraceptives and severe hypertension.


Treatment of duodenal ulcer with glycyrrhizinic-acid-reduced liquorice. A multicentre trial. A double-blind controlled therapeutic trial of glycyrrhizinic-acid-reduced liquorice 760 mg thrice daily for six weeks was carried out on 90 men with relapse of chronic duodenal ulcer. Effects of treatment were judged by the frequency and severity of pain, the amount of alkali consumed, and the doctors' and patients' rating of the clinical response. The results do not show any advantage for the active treatment when compared with the placebo.


Double-cuff endotracheal tube.

Double-cuff endotracheal tube.


In vitro growth inhibition by 3837 compounds tested for antitumor activity: comparison of tumor cell culture and microbial assays.


Measurement of radioactivity in body organs. Report of an International Atomic Energy Agency panel.


Diurnal cycles in plasma FSH, testosterone and cortisol in men.


Combined ovarian and adrenal vein catheterization to determine the site(s) of androgen overproduction in hirsute women.


Effect of biologically active steroids on thyroid function in man.


Measurement of the insulin delivery rate in man.


Effects of triiodothyronine, growth hormone and anabolic steroids on nitrogen excretion and oxygen consumption of obese patients.


Biphasic insulin secretory response to intravenous xylitol and glucose in normal, diabetic and obese subjects.


Cervical and lumbar disc disease: a review.


Administration of growth hormone to patients with familial dwarfism with high plasma immunoreactive growth hormone: measurement of sulfation factor, metabolic and linear growth responses.


Response of gonadotropins and testosterone to clomiphene stimulation in a pubertal body.


Aromatization of androstenedione by the diencephalon.


Tetanus after dental procedures: review of literature and report of case.


Multidisciplinary management of facial deformity: report of a case.


A critical review of management of right colon injuries.


Fat embolism: a review of current concepts.


Management of the extensively burned scalp.


Simpson and Syme of Edinburgh.

Simpson and Syme of Edinburgh.


Joseph Silver Collings.

Joseph Silver Collings.


A new treatment for monilial vaginitis.

A new treatment for monilial vaginitis.


The treatment of plantar warts in the home. A critical appraisal of a new preparation.


Adrien Barrère. A French medical caricaturist. 2.


Organophosphorus pesticides: pharmacology.


Some pyrimidines of biological and medicinal interest. 3.


L-Tryptophane and sleep.

L-Tryptophane and sleep.


Comparison of methods for quantitating bronchial morphology.


99m Tc-labelled serum albumin in cardiac output and blood volume studies.


Successful prolonged resuscitation after open heart surgery.


Studies with glucosyl transferase mutants of the T-even bacteriophages.


Orientation of tail fibers in T4 z mutants and the influence of r mutations.


On the mechanism of int-promoted recombination.


Ovid O. Meyer, MD to be emeritus.

Ovid O. Meyer, MD to be emeritus.


G. A. Behnke, M. D.

G. A. Behnke, M. D.


The problem of hepatitis.

The problem of hepatitis.


Michael Balint 1896-1970.

Michael Balint 1896-1970.


Are antidepressants better than placebo?


Assessing antidepressants' effectiveness.


Microbiological examination of postmortem tissues.


Specificity versus generality in static strength performance: review of the literature.


Separation of nucleosides on polyacrylamide gel columns: further developments.


The effect of polyamines on the methylation of Escherichia coli methyl-deficient transfer RNA by their homologous methylases.


A double-blind clinical trial with a digestive enzyme product.


Production and characterisation of a viral RNA-dependent RNA polymerase induced in Escherichia coli Q. 13  by infection with bacteriophage Q .


Inhibition of lactation--a triple study.


A comparative clinical trial of amitriptyline-perphenazine and chlordiazepoxide in anxious university students.


Assessment of low dosage haloperidol in anxiety states.


Factors affecting choice of and perseveration in social work with the aged.


Ultrastructural and immunofluorescent investigations on the secretin cell in the dog intestinal mucosa.


A possible steric factor in the sensitization of anoxic bacteria to x-rays by N-oxyl radicals.


The chemical inhibition of the repair of single-strand breaks in DNA: post-irradiation sensitization to x-rays.


DNA repair in E. coli B-r after x-irradiation in the presence of iodide or iodoacetamide.


Current methods for the cryopreservation of human leukocytes (granulocytes).


Hospitals in Georgia as of January 1, 1971.


Alphabetical roster of the Medical Association of Georgia.


Clinicopathological conference of the Medical University of South Carolina. "Ileo-cecal intussusception in a 15-year-old girl.


The American College of Clinical Pharmacology.


Functional speech disorders and personality: a decade of research.


Arterial ligation for control of colonic diverticular hemorrhage.


Quantitative histology of the canine coronary collateral circulation in localized myocardial ischemia.


Methodologic considerations of the evaluation of hypnotics in man. A biologic assay of pentobarbital and secobarbital.


Effective renal plasma flow: estimation from theoretical volumes of distribution of intravenously injected 131-I orthoiodohippurate.


Significance of dietary plant sterols in man and experimental animals.


Comparison of prazepam and placebo in the treatment of convalescing narcotic addicts.


Instant experience in clinical trials: a novel aid to teaching by simulation.


The reprint requester as a source of medical information.


The use of a computerized ECG interpretation system in an epidemiologic study.


Lineral discriminatory analysis: a patient classifying method for research and production control.


A comparison of the analgesic effectiveness of glaphenine and standard oral analgesics in postoperative orthopedic patients.


Clonixin: a clinical evaluation of a new oral analgesic.


Regulation of stable RNA synthesis in Escherichia coli.


Primary structural relationship of p16 to m16 ribosomal RNA.


Sequence studies on precursor 16S ribosomal RNA of Escherichia coli.


Structural differences between the 16S ribosomal RNA of E. coli and its precursor.


Additional nucleotide sequences in precursor 16S ribosomal RNA from Escherichia coli.


F 1 -to-maternal skin graftings across the H-2 incompatibility in mice.


A clinical evaluation of a monthly injection for conception control.


People and places.

People and places.


Erythropoietin alterations in human renal disease.


The management of wounds of the innominate, subclavian and axillary arteries.


Hemodynamic effects of vasopressin. An experimental study in normovolemic and hypovolemic anesthetized dogs.


Tissue fractionation and catecholamines. 3. Intracellular distribution of endogenous inhibitors of dopamine- -hydroxylase in adrenal medulla.


Permeability changes induced in the adrenergic neurone by reserpine.


[Directory of the French Society of Ophthalmology, 1966].


Multiphasic health testing in the clinic setting. The economy of automated multiphasic health testing (amht) activities patterned after the high-volume Kaiser program can be realized in low-volume settings. amht units have been operated at daily volumes of 20 patients in three separate clinical environments. These programs have displayed economics entirely compatible with cost figures published by the established high-volume centers. This experience, plus the expanding capability of small, general purpose, digital computers (minicomputers) indicates that a group of six or more physicians generating 20 laboratory appraisals per day can economically justify a completely automated multiphasic health testing facility. This system would reside in the clinic or hospital where it is used and can be configured to do analyses such as electrocardiography and generate laboratory reports, and communicate with large computer systems in university medical centers. Experience indicates that the most effective means of implementing these benefits of automation is to make them directly available to the medical community with the physician playing the central role.Economic justification of a dedicated computer through low-volume health testing then allows, as a side benefit, automation of administrative as well as other diagnostic activities-for example, patient billing, computer-aided diagnosis, and computer-aided therapeutics.


Cellular responses to autologous breast cancer tissue. Correlation with stage and lymphoreticuloendothelial reactive.


Hypothalamic syndrome in acute lymphatic leukaemia.


Combined cyclophosphamide vincristine, and prednisone therapy of malignant lymphoma.


Phenylketonuria and its variations. A review of recent developments.


Global ratings compared to rating scales in evaluating trifluoperazine-amobarbital in anxious psychoneurotic outpatients.


Evidence for glucagon biosynthesis involving a protein intermediate in islets of the anglerfish (Lophius americanus).


Formation and metabolism of testosterone in testicular tissue of immature rats.


Effects of electrochemical stimulation of the ventral hippocampus on hypothalamic electrical activity and pituitary gonadotropin secretion in female rats.


Lesions of the brain and the onset of puberty in the female rat.


Psychoanalysis and historical biography.


Conversion of progesterone by rat medial basal hypothalamic tissue to 5 -pregnane-3,20-dione.


The transference neurosis: a survey of the literature.


The nature of lactose operator constitive mutations.


Selective reaction of methoxyamine with cytosine bases in tyrosine transfer ribonucleic acid.


Synthesis of specific transfer ribonucleic acids during methionine starvation in Escherichia coli 113-3.


Immunohistochemical localization of enterokinase in the porcine intestine.


The glioarchitectonics iof the chicken brain. II. Microglia.


Cholesteric liquid crystals: a new visual aid to study of flap circulation.


Control of muscle contraction.

Control of muscle contraction.


A new probe for reaction kinetics--the spectrum of scattered light.


[Prof. Dr Med. Hans Tichy, May 8, 1888-January 15, 1970].


Combination therapy with cyclophosphamide, vincristine, procarbazine and prednisone in Hodgkin's disease and reticulum cell sarcoma.


Norman Yates McCallum.

Norman Yates McCallum.


Ewan Murray-Will M.B.E.

Ewan Murray-Will M.B.E.


Selecting cases of myelomeningocele for surgery.


Meningomyelocele: the price of treatment.


Haemodialysis-transplantation programme.


Immunosuppression and keratoplasty.

Immunosuppression and keratoplasty.


A theory for the quantification of transcapillary exchange in the presence of shunt flow.


Transcapillary exchange in the working left ventricle of the dog.


Kinetics of rubidium uptake in the working dog heart.


Superior standards of health--our ancient concepts.


Effect of cortisone on Salmonella typhimurium infection in rabbits.


History of the Oklahoma Medical association.


Further notes on the effect of pretest expectancies on the psychological test report.


Body image scores and varieties of consciousness.


Upper left hand placement of human figure drawings as an indicator of anxiety.


Predicting aggression and withdrawal in children with the draw-a-person and Bender Gestalt.


Hiatus hernia and gastroesophageal reflux.


Application of projective tests to psychotherapy: a case study.


Inhibition of norepinephrine biosynthesis by chlorpromazine in the guinea-pig vas deferens.


Bone marrow biopsy in Hodgkin's disease and other neoplastic diseases.


Some early illustrations from an exhibition on 'landmarks in Gastroenterology'.


Thiothixene in chronic schizophrenia. A clinical trial.


Why can't sickle cell patients concentrate urine?


Why cholera may be important to doctors in the U.S.


Historic hospitals: the Community of St. Bartholomew's.


Meet Doctor Darwin.

Meet Doctor Darwin.


Computer-aided medical decision making.

Computer-aided medical decision making.


Cytology in lymphosarcoma cell leukemia.


Ocular findings following radical maxillectomy.


Comparative studies of height and weight as a blood volume reference standard in normal children and children with sickle cell anemia.


Expression of plasma iron turnover in aplastic anemia.


Inhibition of gastric peptic activity by a new sulfate glycopeptide (GLPS).


On the distribution and metabolism of azaperone (R 1929) in the rat and pig.


Plasma levels and urinary excretion of nalidixic acid in patients with renal failure.


The mucolytic agent bromhexine (bisolvon) in chronic lung disease. A double-blind crossover trial.


Assay of parathyroid hormone in disturbances of calcium metabolism.


The structure of viscosin, a peptide antibiotic. II. Syntheses of D- and L-3-hydroxyacylhexapeptides including the proposed structure of viscosin and its optical isomers.


Pyrido[2,3-d]pyrimidine antibacterial agents. I. 8-alkyl-5,8-dihydro-5-oxopyrido[2,3-d]-pyrimidine-6-carboxylic acids and related compounds.


Biological testing for safe O-T-C medications.


The relationship between lesion site, dopamine neurons, and turning behavior in the rat.


Clinical studies of Euphorbia acaulis, Rox b. in cases of eczema--a preliminary report.


Immunohistological studies on gastric mucosal glycoprotein in gastric carcinoma.


Cerebral cysticercosis in India.

Cerebral cysticercosis in India.


Vitamins and minerals in obstetrics and gynecology.


William C. Gorgas: warrior against yellow fever.


An historical and philosophical analysis of dual professional preparation in health and physical education.


The development of glass-fibre bodies in the lungs of guinea-pigs.


Historical review of the Z- and W-plasty. Revisions of linear scars.


Combined operation of cataract and corneal graft.


Morphine.

Morphine.


Managerment of the nonhospitalized patient with chronic obstructive lung disease.


Cornpicker's pupil: Jimson weed mydriasis.


The thymoma-prone (NZB X CFW) F1 mouse.

The thymoma-prone (NZB X CFW) F1 mouse.


Sites of interferon production in rabbits induced by bacterial endotoxin.


The placenta. II.

The placenta. II.


Antilymphocyte serum in tissue transplantation.


Cardiac transplantation.

Cardiac transplantation.


Immunosuppressive effects of soluble cell membrane fractions, donor blood and serum on renal allograft survival.


Polymorphonuclear leukocyte myeloperoxidase deficiency in a patient with myelomonocytic leukemia.


Lester G. Ericksen, M.D. 1899-1971.

Lester G. Ericksen, M.D. 1899-1971.


Rex Dauphin, M.D. 1919-1971.

Rex Dauphin, M.D. 1919-1971.


Current bibliography on allergy and applied immunology.


A comparative clinical study of two cholecystographic agents.


Distribution of blood flow to the muscle and mucosa of the rat esophagus.


Emigration of thymocytes from the thymus: a review and study of the problem.


After two years; eleven heart transplants are still alive.


Section thickness and grain count variation in tritium autoradiography.


Folklore of fifty years in veterinary medicine (1920-1970).


Clinical pathology of cardiac disease. Number thirty-two in a series.


Herodotus: observer of sexual psychopathology.


Biological aspects of trypanosomiasis research, 1965; a retrospect, 1969.


Unilateral renal cortical necrosis. Case report and experimental observations.


Transmissible drug resistance in Enterobacteriaceae isolated from calves given antibiotics.


Membership record keeping problems.

Membership record keeping problems.


Legislative developments.

Legislative developments.


1971 Dental Roster Greater St. Louis Dental Society.


Illinois State Dental Society membership directory, 1971-72.


Bone formation by induction under the influence of growth hormone and cortisone.


Cartilage lysozyme, an extracellular basic (cationic) protein.


Alkali therapy in immobilization osteoporosis.


The need for radiopague denture base materials: a review of the literature.


Pharmaceutical applications of solid dispersion systems.


Van Gough's suicide.

Van Gough's suicide.


William Barry Wood, Jr. May 4, 1910--March 9, 1971.


Dietary fat and coronary heart disease: a review.


Teslac.

Teslac.


A note on tolbutamide and diabetes.

A note on tolbutamide and diabetes.


Perinatal tips.

Perinatal tips.


Effects of anaesthesia, mid-collicular section and variation in blood glucose on spontaneous EEG activity of the cerebellum in cats.


An impression method for single crowns.

An impression method for single crowns.


The "eccentric" repair system of Rotherman. I. A new method for repairing covered abutments of partial and hybrid dentures.


The gingival prosthesis.

The gingival prosthesis.


Practical experience with newer methods and materials. 3.


Surgical sutures.

Surgical sutures.


Sensory deprivation on visceral activity. I. The effect of visual deprivation on canine gastric secretion.


Characteristics of fluorescein labelled antiglobulin preparations that may affect the fluorescent treponemal antibody-absorption test.


Identifying enteric bacteria directly from primary isolation media.


Sylvester Emanuel Gould, M.D., 1900-1970.


Onchocerciasis in Colomba. Historical background and ecologic observations.


Agreement between microscopical diagnosis and indirect fluorescent-antibody tests in Plasmodium vivax and Plasmodium falciparum infections.


Prophylactic and sporontocidal treatment of chloroquine-resistant Plasmodium falciparum from Vietnam.


Comparison of the indirect-fluorescent antibody and indirect-hemagglutination tests for malarial antibody.


Fibrinogen and glomerulonephritis.

Fibrinogen and glomerulonephritis.


Cerebral vasodilators.

Cerebral vasodilators.


Commentary. Clinical pharmacology--Old wine in new bottles?


Metaplastic induction of scales and feathers in the corneal anterior epithelium of the chick embryo.


Central nervous system and cardiovascular effects of lorazepam in man.


Glucagon: present status in cardiovascular disease.


Dose response to codeine in patients with chronic cough.


Analgesic nephropathy--A review of the literature, 1967-1970.


A new method for assessing the clinical effects of oral analgesic drugs.


Otology and Hamlet; Act 1, Scene 5.

Otology and Hamlet; Act 1, Scene 5.


Hypolipidemic, uricosuric, and thyroxine-displacing effects of MK-185 (halofenate).


The hypnotic effects of codeine and secobarbital and their interaction in man.


Plaster tongue-space inserts.

Plaster tongue-space inserts.


Bacteriological observations of hospital commissary environments. I. A bacteriological survey of dishware, eating utensils and warewashers.


Analgesic activity of oral and intramuscular profadol.


Plastic brackets.

Plastic brackets.


Antilipidemic effect of nafenoic acid.

Antilipidemic effect of nafenoic acid.


Insect sting hypersensitivity and its management.


C. C. Howard, M. D. 1888-1971.

C. C. Howard, M. D. 1888-1971.


The association of lymphocytes with larger motile cells in cultures of mammalian thymus.


Studies on thrombosis and thrombolysis by immunofluorescence.


Anti-tumour auto-antibody in human malignant melanoma.


Studies on the turnover of basement-membranes.


Functional overload as a possible cause for non-immune glomerular damage.


Immunohistology of experimental glomerulonephritis in the rat with light and electron microscopy.


Follow-up of correction of severe dual system immunodeficiency with bone marrow transplantation.


Residencies and fellowships.

Residencies and fellowships.


1971-1972 membership roster, Southern California Dental Association.


A new technique for replants and transplants: clinical report of 229 cases.


Cephalaglycin (Kafocin).

Cephalaglycin (Kafocin).


Lithium and manic-depressive psychosis.

Lithium and manic-depressive psychosis.


Flurazepam (Dalmane), a new hypnotic.

Flurazepam (Dalmane), a new hypnotic.


Vitamin C and the common cold.

Vitamin C and the common cold.


Rubella vaccine reconsidered.

Rubella vaccine reconsidered.


Recent developments in the treatment of infectious diseases. II. Alternatives to penicillin in the treatment of infections caused by gram-positive organisms.


Missouri Medicine in review.

Missouri Medicine in review.


Recent developments in the treatment of infectious diseases. 3. Bacterial meningitis.


Return to nursing. Skin grafting.

Return to nursing. Skin grafting.


Stroke survey at a large Midwestern teaching hospital.


Splintage for spina bifida cystica.

Splintage for spina bifida cystica.


The chronic schizophrenic as a research subject: Toxicity measures and their relationship to efficacy measures.


Gel filtration. A new technique for separation of blood platelets from plasma.


Studies on thrombolysis with streptokinase. 3. Morphological examinations of thrombi-thrombus retraction and secondary swelling and the termination of lysibility because of organization.


Shirley A. Johnson (1922-1970).

Shirley A. Johnson (1922-1970).


Survival times of skin xenografts in mice under chronic treatment with antithymocyte serum in different dosage-timing schedules.


Kidney transplantation in the fetal lamb. Technique and histopathology of rejection.


Interpretive study of kidney transplant survival data.


Effects of rejection on the granulation of juxtaglomerular cells in canine renal allografts.


GVH analysis of organ-grafted rats which defy the normal rules for rejection.


Prolongation of canine renal allograft survival by L asparaginase.


Studies on DNA transfer from donor to host tissues in mice.


The epileptic in Virginia. Survey of existing services and facilities.


Determining the level of skilled nursing home care covered under medicaid.


Medicine is dead. Long live the health sciences.


Eleventh Emil A. Gutheil memorial conference. Therapeutic factors in psychotherapy.


Concerning the structure and reproduction of the guinea worm (Filaria medinensis L.) by Aleksej Pavlovich Fedchenko, 1890.


Multiple therapy: its growth and importance. An historical survey.


The depressions and structure: an existential approach to their understanding and treatment.


The Negro in psychiatry. An historical note on psychiatric rhetoric.


Interaction of Leishmania donovani and hamster peritoneal macrophages. A phase-contrast microscopical study.


Treatment of acute falciparum malaria from Vietnam with trimethoprim and sulfalene.


Comparison of pyrantel pamoate and piperazine phosphate in the treatment of ascariasis.


Prevalence of pathogenic enteric bacteria in children of 31 Panamanian communities.


Claude Bernard and anesthesia.

Claude Bernard and anesthesia.


Comparative analysis of intravenous anesthetics.


Comparative clinical pharmacology of local anesthetic agents.


Reticulum cell sarcoma of the spinal epidural space.


Modification of memory storage processes.


DNA synthesis in mammalian nuclei: inhibition of DNA synthesis in the resting rat liver nucleus by ethidium bromide, proflavin and actinomycin D.


Biochemical factors in anxiety neurosis.


DNA-inhibited RNase of E. coli.

DNA-inhibited RNase of E. coli.


The amino acid sequence of the major parvalbumin from hake muscle.


T4 bacteriophage-specific dihydrofolate reductase: purification to homogeneity by affinity chromatography.


Circular dichroism during deacylation of methionyl-tRNA met -f and formylmethionyl-tRNA met -f from E. coli.


The nucleotide sequence of two leucine tRNA species from Escherichia coli K12.


Comparative effects of lithium and chlorpromazine in the treatment of acute manic states.


The physician and the health professions in medieval Islam.


The effect of Medicaid on the supply of podiatrists and the utilization of podiatry services in East Harlem.


Medical numismatic notes. V. University of Edinburgh Anatomy Medal (1893).


Sodium transport in the toad bladder. The functional organization of the granular cell: a review.


Function of the chronically diseased kidney. The adaptive nephron.


Commentary. The Washington Conference on Clinical Pharmacology.


Some cardiovascular effects of marihuana smoking in normal volunteers.


Feline viruses. XIV. Transplacental infections in spontaneous panleukopenia of cats.


Monoamine precursors in the treatment of depression.


Chemotherapy in reticulum-cell sarcoma in five dogs and a cat and in mast-cell leukemia in a cat.


Cardiac output in weanling piglets with bacterial endotoxin shock superimposed on surgical shock.


Decrease of tetracycline absorption in man by sodium bicarbonate.


Characterization and classification of bovine mycoplasma.


Impairment of drug metabolism by disulfiram in man.


Actions and metabolism of heroin administered by continuous intravenous infusion to man.


Antibiotic tolerance and serum levels after intravenous administration of multiple large doses of lincomycin.


Comparison of thioridazine and chlorpromazine in doctor's choice research design.


Diazoxide and renal function in man.

Diazoxide and renal function in man.