Multihospital controlled comparison of the therapeutic effects of four antidepressants.


To the antidepressive properties of lithium and its place in the group of antidepressive drugs.


Comparison of the therapeutic results of clothiapin and perphenazine in schizophrenia.


Thiothixene in schizophrenic psychoses.

Thiothixene in schizophrenic psychoses.


The effects of chlorpromazine on fine psychomotor performance with a simultaneous secondary task in schizophrenics.


The effect of physostigmine on the perception and consolidation phase of memory and learning in alcoholics.


Acute effect of medazepam (15 mg), oxazepam (20 mg) and diazepam (10 mg) on verbal associations.


Ultrastructural alterations in the pancreatic B-cells of the newt (Triturus vulgaris) induced by alloxan.


Kidney preservation by hypothermia using a perfusate medium with "intracellular ion composition". Renal clearances in pigs with autotransplanted 24-hour preserved kidneys.


Immunohistochemical studies of the "X cell" in the human placenta with anti-human chorionic gonadotropin and anti-human placental lactogen.


Stereotaxic atlas of the mesencephalon in the albino rat.


A controlled-environment culture system for high resolution light microscopy.


Chromosomes of the first polar body in mammalian meiosis.


David Mason Little, Jr., M.D.

David Mason Little, Jr., M.D.


Problems of a drug trial (Pemoline) on geriatric patients.


Evaluation of POR-8 (ornithine 8 -vasopressin) as a local vasoconstrictor during halothane anesthesia.


Ultrastructure of 19S antibody-producing cells from ALS, PHA and D2O-treated animals.


A triple crossover, partly blind comparison of the performance and the effect on CNS function of three hand-held methoxyflurane inhalers.


Effects of anti-lymphocyte, anti-macrophage and anti-thymocyte serum IgG on the immune response.


Bupivacaine hydrochloride: a summary  of investigational use in 3274 cases.


In vitro studies of chicken lymphoid cells. IV. The effect of thymectomy on the antibody response in vivo and the in vitro. Reactivity of spleen cells to sheep erythrocytes, allogeneic cells and phytohemagglutinin.


The survival of airborne Serratia marcescens in urban concentrations of sulfur dioxide.


Fine structural localization of cholesterol during fat absorption by bovine intestinal mucosa.


Timed reciprocal dermal-epidermal interactions between comb, mid-dorsal, and tarsometatarsal.


Origin of calcified tissue in regenerating spines of the sea urchin, Strongylocentrotus purpuratus (Stimpson): a quantitative radioautographic study with tritiated thymidine.


An aid to diagnosis: the use of computers in automated clinical pathology laboratories.


Prediction of the in vitro activity of sulfonamides synthesized from simple amines by use of electronic data obtained from the simple amines.


Vasodilators in geriatric psychiatry.

Vasodilators in geriatric psychiatry.


Ca2+ changes in the myocardium following scorpion venom injections.


Preprosthetic surgery from the viewpoint of the prosthodontist.


Surgical treatment of common abnormalities in relation to oral prosthesis.


Vestibuloplasty--skin grafts.

Vestibuloplasty--skin grafts.


Vestibuloplasty, mucosal grafts (palatal and buccal).


Use of alloplastics for ridge augmentation.


Use of mandibular bone for revision of malunion of the maxilla: report of case.


The oral surgeon's role in implant dentures.


Computer-oriented cytology studies.

Computer-oriented cytology studies.


Mast cells in the estrogen-induced transplantable renal tumor of the hamster.


Survival of coliform bacteria in wastewater treatment lagoons.


The use of collagen grafts for replacement of major skin loss.


Caldwell, Luc, and their operation.

Caldwell, Luc, and their operation.


Renal transplantation in Australasia.

Renal transplantation in Australasia.


Australian national renal transplantation survey. Second report by a subcommittee.


John Bell Ferguson.

John Bell Ferguson.


Harry Taylor Hardy.

Harry Taylor Hardy.


Plenary session: computers in medicine.

Plenary session: computers in medicine.


Concurrent session: transplantation biology.


The continued use of amantadine hydrochloride in parkinsonism.


Compartments of leukaemogenic response to radiation.


Construction and uses of a 'data-base' of clinical information concerning 600 patients with acute abdominal pain.


Maurice Levine 1902-1971.

Maurice Levine 1902-1971.


The effects of intravenous lidocaine on optic evoked potentials in light and darkness.


Terminology. Continuous positive pressure breathing valve.


Familial benign chronic pemphigus. Surgical treatment and pathogenesis.


Mycosis fungoides bullosa.

Mycosis fungoides bullosa.


Reduviid bites in an arthropod reactor.

Reduviid bites in an arthropod reactor.


Pemphigus vegetans. Immunofluorescent and ultrastructural studies in a patient.


Serratia marcescens, an ocular pathogen; new considerations.


Jacob Gershon-Cohen, M.D., D.Sc.(Med.).

Jacob Gershon-Cohen, M.D., D.Sc.(Med.).


William John Saxton.

William John Saxton.


The enigma of nasopharyngeal cancer. A selective review incorporating local experience.


The archives of the college. Guide to the history collection. Sundry accessions H331-H344.


Fluorescence of holocrine epithelial cells of the epididymis.


Effects of Paraquat on Escherichia coli and yeast.


Inhibition of macromolecular synthesis in Escherichia coli, L5178Y cells, and mitochondria by ethidium bromide, related compounds, and metabolites.


Estimation of an equivalent "12D" process by the normal distribution method.


Bacterial flora of phyto- and zoo-plankton in the inshore water of Japan.


Seawater salts--hydrostatic pressure effects upon cell division of several bacteria.


Endodontic pins in vented gold post for rehabilitation cases.


A technique for crown and bridge abutment impressions and master cast construction.


Electrokinetic properties of Yoshida sarcoma cells treated with antibodies.


Caffeine and pentagastrin stimulation of human gastric secretion.


Cellular immunity in Crohn's disease.

Cellular immunity in Crohn's disease.


Protein digestion and absorption.

Protein digestion and absorption.


Soviet views on the biological effects of microwaves--an analysis.


Remarks on the environmental adaptation of man.


Apparently monogenic inheritance of anencephaly and spina bifida in a kindred.


Induced chromosome aberrations in unfertilized oocytes of mice.


Interference with respiratory control by ionizing radiations in Escherichia coli B-r.


Geometrical problems in stereotactic surgery: a 3 dimensional analysis for use with computer technics.


Spondylolysis and spondylolisthesis in children and teen-agers.


Arthrodesis of the wrist for rheumatoid arthritis.


Involvement of the hand in epidermolysis bullosa.


Hand reconstruction in arthritis mutilans. A case report.


Regeneration of locally irradiated salamander limbs following superficial skin incisions or nerve transection.


A band and rubber-base impression technique for fixed restorations.


Combinations in fixed-removable prostheses.


Expression of embryonic and ault erythrocyte antigens in hematopoietic repopulated x-irradiated chickens.


Complete dentures opposing natural teeth.


Surgical stents for vestibuloplasty and alveolar ridge skin grafts.


The diagnostic use of computers.

The diagnostic use of computers.


Fabrication of a nose prosthesis.

Fabrication of a nose prosthesis.


The diagnostic process.

The diagnostic process.


The trial of Dr W.R. Hadwen.

The trial of Dr W.R. Hadwen.


Computer-guided diagnosis.

Computer-guided diagnosis.


The history of the college library: the Dorchester Library.


Clinical aspects of drug addiction.

Clinical aspects of drug addiction.


History of the medical society of the District of Columbia. XV.


Proposed mechanism of force generation in striated muscle.


How dextrous was Neanderthal man?

How dextrous was Neanderthal man?


New approach to the synthesis of polyribonucleotides of defined sequence.


Non-identity of apparently similar chromosome aberrations in human lymphoblastoid cell lines.


Application of computer experimentation to the cornea.


Modification of hyperacute rejection of sheep kidney heterografts in the dog using a trypsin inhibitor.


Possible structural and functional differences of the two conformers of myoglobin-like molecules with respect to the haem-haem interaction.


Non-coordinated accumulation and synthesis of 5S ribonucleic acid by ovaries of Xenopus laevis.


Lead absorption from the intestine in newborn rats.


Spanish moss, a sensor for lead.

Spanish moss, a sensor for lead.


Recovery from zoxazolamine paralysis and metabolism in vitro of zoxazolamine in ageing mice.


Mechanism of cellular drug resistance.

Mechanism of cellular drug resistance.


Anal gland secretion of the red fox.

Anal gland secretion of the red fox.


In memoriam.

In memoriam.


Management of patients with myelomeningocele.


Lupus nephritis.

Lupus nephritis.


Ultrastructural pathology of adrenal medullary tumors.


Ultrastructure of human normal and neoplastic prostate.


The case of the Kaiser's cancer.

The case of the Kaiser's cancer.


Lung injury and repair: a contemporary view.


Ultrastructural aspects of acute inflammation.


Embryonal carcinoma of the testis.

Embryonal carcinoma of the testis.


On the use of polarized light in pathology.


Diagnostic problems involving nodal lymphomas.


The critically ill child: sickle cell disease crises and their management.


Double-blind trial of aminophylline in status asthmaticus.


Book of Accidents. Excerpt XVI: climbing trees.


Illuminator for subtraction technique.

Illuminator for subtraction technique.


Hydroxyurea and radiotherapy in head and neck cancer. Results of a prospective controlled study in 126 patients.


Radiology of venous thrombosis--Current status.


In memoriam; Harry Hauser, M.D. 1904-1971.


The periplasmic galactose binding protein of Escherichia coli. A specific high affinity galactose transport system called P(betag) can be induced by trace amounts of galactose in the medium by virtue of its own ability to capture and accumulate galactose. The transport system is coregulated with the production of a high affinity periplasmic galactose binding protein, which constitutes but one part of the transport system. Some transport negative mutants still remain producers of this binding protein. A close correlation exists between production of the active binding protein and the presence of galactose chemotaxis. The hypothesis, that this binding protein is a common element of the specific galactose transport system, P(betag), and of galactose chemotaxis is supported by observations on structural mutants, being defective in galactose binding protein as well as showing a lack of galactose chemotaxis. The binding protein is a monomer with two binding sites for galactose. Binding of one or two of the galactose molecules elicits specific conformational changes of the galactose binding protein (lowered affinity for galactose, increase of charges of the protein, increased fluorescence of tryptophan residues). The importance of these features for transport and for chemotaxis is discussed (70).


Immunotherapy of cancer: immunospecific rejection of tumors in recipients of neuraminidase-treated tumor cells plus BCG. Firmly established methylcholanthrene fibrosarcomas in syngeneic mice will totally disappear if the hosts are treated with living tumor cells that have been exposed to Vibrio cholerae neuraminidase in vitro. The effect is magnified by the simultanieous injection of a nonspecific immunostimulant, BCG. The rejection of the methylcholanthrene tumor is immunospecific and can be induced only with tumor cells, treated with Vibrio cholerae neuraminidase, identical in type with the growing tumor.


Radioiodine dosimetry and the use of radioiodines other than  131 I in thyroid diagnosis.


Scintigraphic evaluation of nodular goiter.


Gonadotrophin and steroid interrelationships during the normal menstrual cycle. The data on blood and urine levels of follicle stimulating hormone (FSH, luteinizing hormone (LH) and estrogens during the normal menstrual cycle are summarized.  The values for plasma progesterone and the urinary excretion of pregnanediol are presented.  The relationship between gonadotrophin and steroid levels with reference to the events at midcycle are considered.  Studies of blood are more valuable that studies of urine to interpret the sequence of events at midcycle.  In the majority of the cycles reported, the midcycle peaks of blood FSH and LH coincide.  The peak of estrogen in blood at midcycle precedes the LH maximum but the time relationship is variable.  During the LH peak a small rise in plasma progesterone occurs, but the major increase in this hormone does not take place until after LH values have decreased.  Ovulation probably does not take place till 12-24 hours after the LH peak.


Pugilistic encephalopathy.

Pugilistic encephalopathy.


Stereoelectroencephalography in temporal epilepsy.


The structural basis for normal and abnormal ureteric motility. The innervation and musculature of the human ureter.


The effect of glutaraldehyde fixation on the primary photochemical processes in bacterial photosynthesis.


New heterologous mischarging reactions with yeast phenylalanyl transfer RNA synthetase.


Template activity of rat liver RNA during development. I. Specificity of polyribosomal RNA in a binding assay.


Studies on translocation IX. The pattern of action of antibiotic translocation inhibitors in eukaryotic and prokaryotic systems.


Studies on the metabolism of ATP by isolated bacterial membranes: formation and metabolism of membrane-bound phosphatidic acid.


Pioneering physician: Samuel Fomon.

Pioneering physician: Samuel Fomon.


Aspirin and the otolaryngologist.

Aspirin and the otolaryngologist.


Studies on ribonucleic acid synthesis in the venom glands of Vipera palaestinae (Ophidia, Reptilia). RNA metabolism in the venom glands of Vipera palaestinae was studied at different stages after manual extraction of the venom (milking). The rate of (32)P incorporation into gland RNA was found to be maximal at 1-4 days after milking in correlation with the height of the secretory epithelium. Venom production attained a maximum only after 8-16 days, in parallel with the accumulation of stable species of cellular RNA.


Nucleic acid enzymology of extremely halophilic bacteria. Halobacterium cutirubrum deoxyribonucleic acid-dependent ribonucleic acid polymerase. 1. DNA-dependent RNA polymerase was purified 150-fold from crude extracts of the extreme halophile Halobacterium cutirubrum. 2. The enzyme requires the presence of native DNA and all four nucleoside triphosphates to incorporate (14)C-labelled nucleoside triphosphate into an acid-insoluble ribonuclease-sensitive product. 3. It has an absolute requirement for both Mn(2+) and Mg(2+). 4. The polymerase requires a high salt concentration for stability, but is markedly inhibited by univalent cations. 5. Its molecular weight is very low compared with that of Escherichia coli RNA polymerase.


Magnesium-induced conformational change in transfer ribonucleic acid as measured by circular dichroism.


Harold Harrison Cole.

Harold Harrison Cole.


Bovine pepsinogens and pepsins. 3. Composition and specificity of the pepsins.


The effect of halothane on bacterial growth rate.


Genetic influence on gonadotropic activity in mice.


Transtracheal ventilation.

Transtracheal ventilation.


Bilateral tension pneumothorax occurring during operation.


Anaesthesia for laminectomy and localized cord cooling in acute cervical spine injury. Report of three cases.


An experimental approach to mandibular replacement: island vascular composite rib grafts.


A rapid method for constructing a functional sensitive penis.


Reconstruction of the thumb using two flaps from the same hand.


Reconstruction of both eyelids following traumatic loss.


Obituary. George Henry Morley.

Obituary. George Henry Morley.


Tissue isoantigens A, B, and H in carcinoma of the pancreas.


Acute changes in left ventricular volume and contractility during ventricular pacing in patients with complete heart block.


A study of the incidence and mortality of measles and whooping cough in Glasgow from 1855, with reference to birth rates, death rates and death rates of children under one year.


Symposium on pertussis immunization, in honor of Dr. Pearl L. Kendrick in her eightieth year: introduction.


Symposium on pertussis immunization, in honor of Dr. Pearl L. Kendrick in her eightieth year: pertussis control--1970.


Symposium on pertussis immunization, in honor of Dr. Pearl L. Kendrick in her eightieth year: current status of combined vaccines.


Contrasting actions of cis- and trans-clomiphene on the release of FSH and FSH-RF in the female rat.


Plasma concentrations and rates of plasma clearance and production of cortisol and corticosterone in healthy persons and in subjects with asymptomatic and clinical diabetes mellitus.


Evidence for a stimulatory effect of ketone bodies on insulin secretion in man.


The effect of zinc in the healing of burns.


The tangential excision of burns: an experimental study using an animal model.


The history of blood transfusion.

The history of blood transfusion.


131 I-labeled colloidal human serum albumin in the study of reticuloendothelial system function. II. Phagocytosis and catabolism of a test colloid in normal subjects.


131 I-labeled colloidal human serum albumin in the study of reticuloendothelial system function. 3. Phagocytosis and catabolism compared in normal, leukemic, and immunosuppressed human subjects.


A Salmonella carrier state involving the upper respiratory tract of mice.


Ossiculoplasty: Experimental studies of cortical bone grafts for replacement of the incus in cats.


Alabamian one of four to be honored by ACCP.


Scurvy as an occupational disease. IV. Scurvy and the nations' men-of-war.


Chemistry of cephalosporin antibiotics. 25. 3-Cyanomethyl cephem nucleus.


Sustained-release formulation of prednisolone administered orally to man.


Pharmaceutical sciences--1970: literature review of pharmaceutics.


The history of the College Library, 1688-1727.


Immunosuppressant agents in the treatment of glomerulonephritis. 2. Cytotoxic drugs.


Comparison of two methods of estriol determination.


Computer-oriented cytology studies.

Computer-oriented cytology studies.


Discussion on idiopathic cardiomyopathy.


A simple technique for comparative light and electron microscopy of designated living cultured cells.


Surgical modification of the personality.


Laurence Osborne Rutherford.

Laurence Osborne Rutherford.


Influence of growth phase on UV induced lethality and DNA breakdown in a Kornberg polymerase deficient resA strain of Escherichia coli.


Mutations allowing growth on maltose of Escherichia coli K 12 strains with a deleted malT gene.


Control of leftward transcription in the immunity region of Escherichia coli phage lambda.


Host- and phage-RNA polymerase mediated synthesis of T 7  lysozyme in vivo.


Coronary gas endarterectomy. Technical aspects in its application.


Sir Charles Ernest Hercus, D.S.O., O.B.E., M.D., B.D.S., D.P.H. (N.Z.), Hon. L.L.D. (Otago), F.R.C.P. (Edin.), F.R.C.P., F.R.A.C.P., F.R.A.C.S., Hon. M.R.C.P.A.


New trends in lymphoma management.

New trends in lymphoma management.


Influence of recirculation on myocardial clearance curves with xenon 133.


The fidelity of a sampling-recording system used for myocardial clearance curves with xenon 133 as an indicator.


Hyperostosis corticalis generalisata. Eight new cases.


Hepatic blood flow during late pregnancy.


Microscopy of the neonatal line in developing human enamel.


Lung puncture and aspiration.

Lung puncture and aspiration.


Reevaluation of ampicillin therapy for Hemophilus influenzae meningitis. An appraisal based on a review of cases of persistent or recurrent infection.


Clinical and pathologic evaluation of ruptured cranial cruciate ligament repair in the dog.


Isolation and partial characterization of histidine decarboxylase and edema disease-inducing toxin of Escherichia coli strain O139K82H1.


Escherichia coli O149:K91, K88ac:H10 isolated from pigs with colibacillosis in the United States.


H. Houston Merritt.

H. Houston Merritt.


Molecular properties of Tunicate DNA.

Molecular properties of Tunicate DNA.


Effects of macrolide antibiotics on the ribosomal peptidyl transferase in cell-free systems derived from Escherichia coli B and erythromycin-resistant muytant of Escherichia coli B.


Utilization of deoxyribonucleoside diphosphates by toluene-treated Escherichia coli cells lacking deoxyribonucleic acid polymerase I.


Amino acylaminonucleoside inhibitors of protein synthesis. II. Effect on oligophenylalanine formation.


Studies on low molecular weight RNA of chromatin. Effects of template activity of chick liver chromatin.


Treatment of acute lymphoblastic leukaemia. Comparison of immunotherapy (B.C.G.), intermittent methotrexate, and no therapy after a five-month intensive cytotoxic regimen ((Concord trial). Preliminary report to the Medical Research Council by the Leukaemia Committee and the Working Party on Leukaemia in Childhood. One hundred and ninety-one cases of acute lymphoblastic leukaemia were entered in a trial in which, for five months, all received cytotoxic therapy with prednisolone, vincristine, mercaptopurine, L-asparaginase, and methotrexate (the latter in high dosage followed by folinic acid). Patients were then randomized to receive immunotherapy (B.C.G.), twice-weekly methotrexate, or no further treatment.One hundred and seventy-seven patients (93%) achieved full remission and at the time of analysis, 26 months from the beginning of the trial, 143 were still alive, including 70 in their first remission. Median "post-intensive" remission lengths were 17 weeks (no treatment), 27 weeks (B.C.G.), and 52 weeks (methotrexate). The prolongation of remission by methotrexate was most evident in those patients with low initial white cell counts. B.C.G. seemed to cause lymphocytosis but was without other conspicuous effect. The incidence of toxic reactions is reported, including an unusually low rate of anaphylaxis with L-asparaginase.These preliminary results are discussed and compared with those of similar trials.


Hyposensitization with Dermatophagoides pteronyssinus antigen: trial in asthma induced by house dust. A double-blind clinical trial of hyposensitization with aqueous extracts of Dermatophagoides pteronyssinus (the house-dust mite) and human skin scales showed a substantial improvement in symptoms in 11 asthmatics allergic to house dust treated with the D. pteronyssinus extract and a reduction in their need for other therapy. Five patients were well for a year but six relapsed. These results contrasted with the generally unfavourable course of the patients treated with the extract of human skin scales. Asthma due to house-dust allergy may be substantially improved by hyposensitization with D. pteronyssinus extract.


A kidney from the family.

A kidney from the family.


Centenary of the birth of Robert Hutchison.


Jakob-Creutzfeldt disease: treatment by amantadine.


Side effects of intermittent rifampicin.


Effects of a new oral hypoglycemic agent on glucose and insulin after oral glucose loading. A controlled study.


Chronic tension headache--treated with amitriptyline--a double-blind study.


Clinical trial of MY-25 (1-methyl-ergotamine-bitartrate) in migraine prophylaxis.


A demonstration of sub-population of rosetting cells in lymph nodes from sensitized guinea-pigs by zonal centrifugation.


A slide antigen in the indirect fluorescent antibody test for Trichinella spiralis.


The concurrent validity of unobtrusive measures of conflict in small isolated groups.


Spontaneous release of cytotoxic alloantibody from viable cells sensitized in excess antibody.


Color in House-Tree-Person drawings by college men and women.


The sun as a measure of dependency in children's drawings.


Synthesis and secretion of local immunoglobulin by the intestinal tract of newborn rabbits.


Presumptive identification of bacteria from blood cultures in four hours.


Deuterium isotope effect in chloramphenicol action.


Evaluation of a temperature-sensitive mutant of respiratory syncytial virus in adults.


Metabolism of 3-( , , -trifluoro-m-tolyloxy)-1,2-propanediol 1-carbamate in man.


Some new antibacterial quinoxaline N,N-dioxide derivatives.


The clinical significance of autoantibody detection.


Daniel Oxenbridge, John Twysden, and William Harvey.


The College and Europe. The Langdon-Brown lecture.


Human prostatic adenocarcinoma: growth in monolayer tissue culture.


Treatment of urinary tract infections with cephalexin.


Bacteriuria in intestinal loop urinary diversion in children.


Renaissance of urethroplasty: the Belt technique of hypospadias repair.


Suppression of physical dependence and induction of hypersensitivity to morphine by stereotaxic hypothalamic lesions in addicted rats. A new theory of addiction.


Adult hypertrophic pyloric stenosis described by G. B. Morgagni.


Ultraviolet radiation sensitivity of white mutants and red wild-type Serratia marcescens.


Alvin Thomas Wallace.

Alvin Thomas Wallace.


Leslie F Nims.

Leslie F Nims.


Using scrapings from formalin-fixed tissues to diagnose leptospirosis by fluorescent-antibody techniques.


Cryostat sectioning; modification of the antiroll plate.


Advantages of epoxy resin as a mounting medium for light microscopy.


The evolution of scientific method in medicine.


Scanning and transmission electron micrographs of the same frozen fractured surface.


Glycol for controlling evaporation in mounting of frozen brain sections.


Peritonitis due to Salmonella typhimurium complicating nutritional cirrhosis.


Needle-track reference marks of India ink for right-left orientation of brain sections.


The effect of some herbicides on Azotobacter chroococcum.


Observations on Pseudomonas sp. highly tolerant to creosote, isolated from railway wood sleepers.


The use of dithiothreitol in in vitro studies on rumen microflora.


Seroneutralization and splenoneutralization tests in the course of rats rabies caused by the short time incubation strain.


Studies on the interaction of phytomitogens with lymphoid cells. I. Binding of phytohaemagglutinin to cell membrane receptors of cultured Burkitt's lymphoma and infectious mononucleosis cells.


Organisms and their sensitivities among hospital patients. II. Resistance transfer in relation to typhoid infections.


Organisms and their sensitivities among hospital patients. I. Ecology.


Epidemiology of epilepsy in European and American populations: a review.


Immunoglobulin levels, malarial antibody titres and placental parasitaemia in Nigerian mothers and neonates.


Amytriptyline and chlordiazepoxide (Limbitrol) in depressive states in Nigerians--a double-blind study.


Therapeutics of nature--the invisible sutures of "spontaneous closure".


Quadric analysis in the preoperative distinction between patients with and without adrenocortical tumors in hypertension with aldosterone excess and low plasma renin.


The arterial pulse in health and disease.


Comparison of therapeutic effects of coronary drugs in the USSR.


Bretylium tosylate.

Bretylium tosylate.


The chemical sciences.

The chemical sciences.


The development of seismology from biblical times to 1970.


Intestinal antigenicity of ovarian mucinous cystadenomas. Immunofluorescent tracing by rabbit antiserum with specific reactivity against intestinal mucosa revealed cross-reaction with human ovarian mucinous cystadenoma epithelium and not with epithelium of any of several other human mucous epithelia. The mucinous cystadenoma epithelium apparently contains at least one but not all of the specific intestinal mucosal antigens. The findings support the view that such tumours are histogenetically of intestinal type, as might occur for example by unilateral intestinal development of a teratoma.


Immunodepression during urethane and N-nitrosomethylurea leukaemogenesis in mice. Five injections of urethane, 1 mg./g. body weight to suckling mice markedly reduced the primary immune response against sheep red blood cells assessed by splenic plaque forming cells (PFC) determination and haemagglutinin (HA) titration. The immunological impairment lasted for about 50 days after the end of the treatment. The secondary response tested by HA titration was not affected. A lower dose of urethane (0.5 mg./g.) produced only a delay of the primary HA response. A single neonatal dose of N-nitrosomethylurea (NMU) caused a profound immunodepression evaluated as HA titre and number of PFC. Both primary and secondary responses were still depressed when tested at 50 and 90 days of age respectively. No clear correlation between the degree of immunodepression and lymphoma development was found.


Prophylaxis of wound infection.

Prophylaxis of wound infection.


Effect of ultrasonic nebulization on blood gas tensions in chronic obstructive lung disease.


Aspergillus infection of prosthetic aortic valves.


Surface active agents in sputum evacuation: a blind comparison with normal saline solution and distilled water.


Experience with mesh grafting.

Experience with mesh grafting.


Apparently spontaneous chromosome damage in human leukocytes and the nature of chromatid gaps.


Clinico-pathologie conference. Adenocarcinoma of the sigmoid colon with ulceration.


Electron probe analysis for iodine in human thyroid and parathyroid glands, normal and neoplastic.


Effect of rifamycins and related antibiotics on the deoxyribonucleic acid-dependent ribonucleic acid polymerase of vaccinia virus particles. A number of compounds related to rifampin which act as expected in the Escherichia coli system have been tested for their ability to inhibit the vaccinia particle deoxyribonucleic acid-dependent ribonucleic acid (RNA) polymerase in vitro. Some compounds are inactive even at concentrations of 500 mug/ml, others are able to produce partial inhibition, and others strongly inhibit the enzyme activity at 150 mug/ml or less. The inhibition, where present, operates immediately but appears to be at least partially reversible. At least one compound which is without effect against bacterial RNA polymerase is a potent inhibitor of the viral RNA polymerase. As the enzyme activity of rifampin-resistant mutants of vaccinia virus is inhibited to the same extent as that of the wild type, the observed in vitro effect on vaccinia virus RNA polymerase is not identical with the in vivo effect specifically directed against a vaccinia-specified protein.


Genetic assay for small fragments of bacteriophage phi X174 deoxyribonucleic acid. The double-stranded replicative form deoxyribonucleic acid (RF-DNA) of bacteriophage phiX174 was fragmented by pancreatic deoxyribonuclease, and the complementary strand fragments were then annealed to intact viral single strands. When such complexes infected Escherichia coli spheroplasts, some of the progeny virus bore genetic markers derived from the RF-DNA fragments. In this way, genetic markers have been salvaged from DNA fragments less than 50 nucleotides in length. This method is potentially useful as a specific assay to aid in the purification of genetically defined DNA fragments and also as a mechanism for the incorporation of small chemically synthesized DNA sequences into viral genomes.


Role of gene 46 in bacteriophage T4 deoxyribonucleic acid synthesis. In an attempt to establish whether Escherichia coli B infected with N130 (an amber mutant defective in gene 46) is recombination-deficient, the postinfection fate of (14)C-labeled N130 parental deoxyribonucleic acid (DNA) was followed, its amount in complex with the host cell membrane being determined in sucrose gradients after mild lysis of the infected cells. The parental DNA was found to undergo gradual detachment from the membrane during infection. Pulse-chase experiments similarly showed that newly synthesized DNA is normally attached to the host cell membrane and is detached by endonucleolytic breakage at a late stage of infection. The conclusion is that only attached DNA molecules are replicated by membrane-bound replicase, whereas those detached by endonucleolytic breakage are not. It thus seems that the gene 46 product controls the activity of a nuclease whose main function is recombination of DNA nicked by endonuclease, thereby attaching it to the host cell membrane. The rate of T4 DNA synthesis is apparently governed by the efficiency of recombination. Supporting evidence was found in experiments with the double mutant N130 x N134 (genes 46, 33).


Mental hygiene influences in children's institutions: organization and technology for treatment.


The background of today's social psychiatry.


Antimicrobial effect of topical anaesthetics.


Computerized comparison of histological methods for the evaluation of cranio-facial growth.


Genetically determined immune deficiency as the predisposing cause of "autoimmunity" and lymphoid neoplasia.


Conduction disturbances of the left bundle branch system and their relationship to complete heart block. II. A review of differential diagnosis, pathology and clinical significance.


Choriocarcinoma in a man. The relationship of gynecomastia to chorionic somatomammotropin and estrogens.


Anatomical evidence of pre-columbian syphilis in the West Indian Islands.


The prognostic value of some histopathological criteria for the diagnosis of giant follicular lymphoma as judged from a routine material.


Prediction of craniofacial growth: the state of the art.


Epidural analgesia with plain bupivacain. A comparison of the analgetic properties of Carbocaine with adrenaline and plain Marcaine.


The epinephrine response of isolated rabbit vascular strips after in vivo and in vitro endotoxin exposure.


Differential effect of alterations in the calcium and magnesium concentrations on the responses to sympathomimetic amines of the perfused rat mesentery.


Intracellular enzymes in local lymph during homograft rejection.


The vulnerability of immature rabbits to experimental allergic neuritis: a light and electron microscope study.


Relative potency of intravenous prinodolol and propranolol in man.


Acute porphyria, toxic and genuine in the light of history. A re-evaluation of sulphonal-trional porphyria, the first pharmakon-provoked inborn error of metabolism.


Acid and pepsin secretion in response to insulin after truncal vagotomy in man.


Biguanides and gastric emptying in man.

Biguanides and gastric emptying in man.


The inhibitory effect of oxytetracycline on the glucose degradation in human erythrocytes.


Hyperactivity and learning disorders: review and speculation.


Bridging the gap.

Bridging the gap.


Metabolism of N-methyl-N'-nitro-N-nitrosoguanidine in rats.


The legacy of the Mathews Orations.

The legacy of the Mathews Orations.


Review of literature on diseases of the colon and rectum, May-June, 1970.


Techniques for the examination of excised lungs.


Pathophysiology of cholestasis.

Pathophysiology of cholestasis.


Bernardino Ramazzini (1633-1714): de morbis artificum.


A modern concept of the emphysemas based on correlations of structure and function.


Katharine Elizabeth Manchester, President, The American Dietetic Association.


Edith A. Jones receives 1971 Copher Award.


The damaging effects of a disaligned musculoskeletal system.


Copper band and tray technique for anterior jacket and crown impressions.


Cable parameters, sodium, potassium, chloride, and water content, and potassium efflux in isolated external intercostal muscle of normal volunteers and patients with myotonia congenita. In isolated fiber bundles of external intercostal muscle from each of 13 normal volunteers and each of 6 patients with myotonia congenita, some or all of the following were measured: concentrations of Na(+), K(+), and Cl(-), extracellular volume, water content, K(+) efflux, fiber size, fiber cable parameters, and fiber resting potentials. Muscle from patients with myotonia congenita differed significantly (0.001 <P< 0.025) with respect to the following mean values (myotonia congenita vs. normal): the membrane resistance was greater (5729 vs. 2619 omega.cm(2)), the internal resistivity was less (75.0 vs. 123.2 omega.cm), the water content was less (788.2 vs. 808.2 ml/kg wet weight), and the mean resting potential was greater (68 vs. 61 mv).NO SIGNIFICANT DIFFERENCES WERE FOUND WITH RESPECT TO THE FOLLOWING VARIABLES: K(+) content (73.5 vs. 66.7 mEq/kg wet weight) and the calculated intracellular K(+) concentration (215 vs. 191 mEq/liter fiber water), fiber capacitance (5.90 vs. 5.15 muf/cm(2)), Na(+) content (97.7 vs. 94.1 mEq/kg wet weight), Cl(-) content (79.0 vs. 74.7 mEq/kg wet weight), mannitol extracellular volume (45.1 vs. 46.6 cc/100 g wet weight), and K(+) efflux (23.2 vs. 21.5 moles x 10(-12) cm(-2).sec(-1)). These abnormalities of skeletal muscle in human myotonia congenita are like those of skeletal muscle in goats with hereditary myotonia. We tentatively conclude that a decreased Cl(-) permeability accounts for some of the abnormal electrical properties of skeletal muscle in myotonia congenita.


Synthesis of 2-methylpteridine derivatives.


Localized pretibial myxedema and thyroid acropachy in a case of Hurthle cell adenocarcinoma.


The transmissible nature of enterotoxin production in a human enteropathogenic strain of Escherichia coli.


Hypersensitivity of young piglets to Escherichia coli endotoxin.


Aerobic bacterial counts on human skin after bathing.


Samuel Phillips Bedson. 1 December 1886--11 May 1969.


The frequency of salmonellae in wild ducks.


Effects of chlorpromazine on reticuloendothelial phagocytosis and antibody formation in mice.


Limited vaginal surgery for urinary stress incontinence.


Successful urologic management of inadvertent rectal injuries.


Urologic aspects of renal transplantation in children.


Salute to the clinical pathologists.

Salute to the clinical pathologists.


Vincent Van Gogh and glaucoma.

Vincent Van Gogh and glaucoma.


Nonsense mutants and the genetic code. A small piece of molecular genetics.


Tryptophan biosynthesis in Escherichia coli. Genetic determination of the proteins involved.


A neurological tapestry.

A neurological tapestry.


National transplant communications network.


Long-term function after human heart transplantation.


The UGDP study.

The UGDP study.


Drug resistance of staphylococci. Ability of chloramphenicol related compounds to induce chloramphenicol resistance in Staphylococcus aureus.


Sterility testing procedures in a pharmaceutical factory.


Classification systems of the Bacteroides group.


The rapid identification of Gram-negative bacilli.


Some observations on Clostridium tetani.


Teacher of medicine in history.

Teacher of medicine in history.


Complications of orbital fractures.

Complications of orbital fractures.


Library of the Society of the New York Hospital.


[Polish traditions at the Wroclaw Department of Gynecology prior to 1918].


Albert James Myer: army physician and climatologist.


Clinical climatology in Colonial Carolina: 1670-1776 (Charleston and South Carolina).


Tricuspid valve disease. An historical and physiological perspective.


Memorial. Harrison Fitzgerald Flippin (1906-1968).


Lung water: physiological and clinical significance.


Memorial. Roy Ross Snowden, M.D.

Memorial. Roy Ross Snowden, M.D.


Philosophical direction of medical thinking from Mather to Snow.


Historical relationships between tissue culture and transplantation experiments.


Memoir of William T. Branen 1906-1970.

Memoir of William T. Branen 1906-1970.


Memoir of Chalmers E. Cornelius 1902-1970.


Memoir of Clifford Bailey Farr 1872-1970.


Officers, committees, sections, administrative staff of the College of Physicians of Philadelphia 1971.


Memoir of Bernard Pierre Widmann 1890-1971.


Bibliography of George D. Snell.

Bibliography of George D. Snell.


Immunogenetic components of weaker histoincompatibility systems in mice.


Strain C57BL-10ScSn and its congenic resistant sublines.


Dynamics of immunologic enhancement.

Dynamics of immunologic enhancement.


Phylogenetic status of immune system in Xenopus.


Genetics of tissue transplantation in Teleostei.


Transplantation immunity and tolerance in Anurans.


Publications of E. Richard Weinerman, M.D.


E. Richard Weinerman, M.D., M.P.H. (July 17, 1917--February 21, 1970).


Fracture healing in compression osteosynthesis. An experimental study in dogs with an avascular, diaphyseal, intermediate fragment.


Ascorbic acid and the common cold.

Ascorbic acid and the common cold.


A sodium-dependent sugar co-transport system in bacteria.


The modification by acridine analogs of the survival of ultraviolet irradiated Escherichia coli B.


Purification, amino acid composition and N-terminus of the hypothalamic luteinizing hormone releasing factor (LRF) of ovine origin.


Zinc in DNA polymerases.

Zinc in DNA polymerases.


-naphthyl-azo-polystyrene-insulin as a means of protecting insulin molecule from digestive enzymes.


A method for measuring the content of a specific messenger ribonucleic acid in Escherichia coli. A method is described for measuring the porportion of a specific messenger RNA in the total RNA extracted from pulse-labelled cells. A model system consisting of total ribosomal RNA and Escherichia coli DNA is used to validate the method and to define the conditions under which it can be used.


Mutation and "reversion" at the leu-5 locus of neurospora and its effect on the cytoplasmic and mitochondrial leucyl-tRNA synthetases.


Transitory ambiguity in polyuridylic acid translation with Escherichia coli ribosomes.


Galactose-specific messenger ribonucleic acid contents in Escherichia coli. A method is described for measuring the proportion of galactose-specific mRNA (gal-mRNA) in the total RNA extracted from pulse-labelled cells of Escherichia coli K12, by DNA-RNA hybridization with DNA prepared from bacteriophage lambdadg. RNA from wild-type E. coli was compared with RNA from a homogenote carrying the gal operon both in the chromosome and in a substituted sex-factor, and with RNA from a deletion strain that carried the galactose operon only in the exogenote. In each case the cultures were induced with fucose. Under these conditions the amount of gal-mRNA was found to be proportional to the content of galactokinase in the different cultures, and to the gene frequency. The amounts of gal-mRNA in an O(c) mutant and an R(-) mutant were also proportional to the observed contents of galactokinase. In cultures repressed for the enzymes of the galactose operon with thiomethylgalactoside, the content of gal-mRNA was higher than expected from the content of galactokinase. Possible explanations of this finding are discussed.


The use of zonal centrifugation in the preparation of glomeruli and tubular fragments from rat kidney.


Precision specifications for the estimation of treatment differences.


The number of sex-factors per chromosome in Escherichia coli. A substituted sex-factor of Escherichia coli, F'8 gal, was transferred to Proteus mirabilis by conjugation. The DNA of the episome was partially purified from Proteus DNA by preparative equilibrium centrifugation in caesium chloride, and by a bulk method using hydroxyapatite. The buoyant density of the episomal DNA is 1.707, corresponding to a (G+C) content of 47%. By optical renaturation the genetic complexity of the episomal DNA was found to be 76x10(6) daltons. RNA was synthesized in vitro by using the episomal DNA as template. By hybridizing this RNA with DNA extracted from E. coli carrying F'8 gal, it is shown that the number of copies of the episome per replicating chromosome is close to two during exponential growth. The episome makes up about 4.4% of the total DNA of the growing cells. The activities of galactokinase and galactose 1-phosphate uridylyl-transferase in cells with and without episomal and chromosomal gal genes were found to be proportional to the number of gal genes present, when the cells were induced with d-fucose, but not when they were induced with d-galactose.


International aspects of the study of adverse reactions to drugs.


The use of prior information in the testing of new drugs.


Mercury hazards associated with high speed mechanical amalgamators.


Wrought wire retainers. A method of increasing their flexibility.


A stereotaxic atlas of the opossum brain (Didelphis virginiana).


Effects of short-term culture on populations of hemopoietic progenitor cells from mouse marrow.


The influence of a low environmental temperature on the stem cell population of the bone marrow and intestinal mucosa.


Professor Bronislaw Gi edosz, M.D., 1905-1970.


Management of acute childhood poisoning.


Corneal vascularization in experimental uveitis and graft rejection. An electron microscopic study.


L. M. Monheim, famed anesthesiologist, dies.


Oral disease in 181,338 consecutive oral examinations.


Prevention and control of periodontal disease.


Accuracy of a mercaptan rubber impression technique using a stock tray.


Chorismate mutase-prephenate dehydratase. Phenylalanine-induced dimerization and its relationship to feedback inhibition.


Amino acid sequence of porcine neurophysin-I.


ppGpp formation in Escherichia coli treated with rifampicin.


The small atrial septal defect--operate or procrastinate?


The development of hemostasis in the human fetus and newborn infant.


Small kidneys, polyuria, growth retardation, and renal failure.


Risks of rhythm method of birth control.


Morphological and biological changes induced by thallium acetate in Escherichia coli.


Studies on the persistent infection with measles virus in HeLa cells. I. Clonal analysis of cells of carrier cultures.


Drug-resistance and distribution of R factors among Proteus strains.


Founding of the John Staige Davis Society of Plastic Surgeons of Maryland, Inc.


Etiological aspects of carcinoma of the colon.


Medicine in Maryland in the 17th and 18th centuries.


Molecular interactions of ribosomal components. II. Site-specific complex formation between 30S proteins and ribosomal RNA.


Intra-cistronic complementation among trpC mutants of Escherichia coli.


A correlation between sensitization to gamma-rays by purine starvation and the rec genes in Escherichia coli K-12.


Suppression of temperature sensitive mutants of bacteriophage T4 by bacterial opal suppressors.


Requirement of thymus-dependent lymphocytes for potentiation by adjuvants of antibody formation.


Variations of the expression of HL-A antigens on human diploid fibroblasts in vitro.


Scrapie in immunologically deficient mice.


Extraction of prostaglandins from human blood.


Spontaneous rhythms in physiological control systems.


Decreased feeding after injections of amino-acids into the hypothalamus.


Teratogenicity studies of methadone HCl in rats and rabbits.


CO 2 -dependent oxygen evolution by envelope-free chloroplasts.


Evaluation of bicuculline as a GABA antagonist.


Egg transfer in domestic animals.

Egg transfer in domestic animals.


Cytogenetic analysis of a Chinese hamster-mouse hybrid cell.


Bacterial virus gene expression in human cells.


The role of distortion in the lysozyme-catalysed hydrolysis of glucosides.


In vitro culture of rabbit ova from the single cell to the blastocyst stage.


Potentiation of amphetamine-induced arousal by starvation.


Effects of 6-hydroxydopamine on sleep in the rat.


Rhodopsin-like protein from the purple membrane of Halobacterium halobium.


Single and repeat dose effects of imipramine and chlorpromazine in man.


Comparative effects of single and repeat dose administration of antianxiety agents.


Chemical evolution and the origin of life. A comprehensive bibliography.


Preparation of tissue for scanning electron microscopy: freeze-fracturing as a technique for enhancing visibility of structural relationships.


Drinking-straw molds for embedding multiples of longitudinal segments for cryostat sectioning.


Mast cells in the islets of Langerhans in insular amyloidosis.


A gas-chromatographic method for the determination of oxygen uptake in aerated cultures.


Morphological patterns of the organ of Corti in birds.


A graded approach to the management of penetrating wounds of the heart.


Tracheal compression by the great arteries in the mediastinum. Report of 39 cases.


The unborn child.

The unborn child.


Restraint in the treatment of the mentally ill in the late 19th century.


Robert Barnes and his obstetric forceps.


The king's evil and its Polynesian counterpart: a contribution of clinical ethnopsychiatry to medical history.


Disulphide bridges of the heavy chain of human immunoglobulin G2. Amino acid sequences around the disulphide bridges of the heavy chain of an immunoglobulin of the gamma2 subclass have been studied. The protein was digested with pepsin and the digest fractionated by Sephadex. Screening of the eluate by one-dimensional electrophoresis of oxidized and unoxidized samples was used as an assay and pools of fractions were prepared. Identification by diagonal electrophoresis of several inter- and intra-chain disulphide bridges was done on the pooled fractions. The inter-heavy-chain bridged peptide included four cystine residues. Comparison with proteins of other human subclasses indicated that the intrachain bridges identified are the bridges of the invariable section of gamma2 heavy chains. The amino acid sequence of one cysteic acid peptide that may have been derived from the variable part of the molecule was determined. Partial reduction followed by carboxymethylation with radioactive iodoacetate of two proteins of the gamma2 class showed a number of labelled peptides that could be identified as being related to the inter-chain bonded cystine residues.


The diffusion capsule, a novel device for the addition of a solute at a constant rate to a liquid medium. Its application to metabolic regulation. The diffusion capsule consists of a cylindrical container that can be completely filled with a solution and sealed with a small semi-permeable membrane at one end. In use, the capsule is immersed in an agitated liquid. Experiments on concentrated solutions in the capsule showed that, contrary to diffusion theory, the rate of diffusion of solute (sugars or amino acids) out of the capsule remained virtually constant until about 65% of the solute had diffused out of the capsule. Thus the device has been used to maintain constant material feed rates for periods exceeding 30h. The capsule is a simple and compact substitute for a pump and is superior to a pump for small feed rates in many applications. The capsule greatly extends the scope of the shake-flask culture technique for micro-organisms in that substrate-limited growth, possibly the aspect of greatest interest, is readily achieved simply by dropping in the flask a capsule containing the substrate. Diffusion feed should facilitate study of the metabolism of toxic substrates: also it is likely to provide an improved means for supplying a pulse of tracer to a culture.


Bovine pepsinogens and pepsins. A series of zymogens and enzymes that differ in organic phosphate content. Several minor pepsinogens, present in extracts of bovine fundic mucosa obtained from the fourth stomach or abomasum, were separated from the main pepsinogen by chromatography on hydroxyapatite at pH7.3. The major pepsinogen and two of these minor pepsinogens were studied in detail. All three zymogens have N-terminal Ser-Val-, C-terminal -Val-Ala and not more than 1mol of glucose/mol of protein; no significant differences in amino acid composition were found. The pepsinogens differ in their organic phosphate content, which accounts for their chromatographic separation. By activation at 0 degrees C and pH2, a corresponding series of pepsins is formed. These enzymes were separated by hydroxyapatite chromatography at pH5.7. All the pepsins have N-terminal valine, C-terminal alanine and are free from carbohydrate. Again the only difference detected among them is in their organic phosphate content. The pepsins of high phosphate content are converted by an acid phosphatase in vitro into pepsins of low phosphate content.


Repeated assessment of results in clinical trials of cancer treatment.


A case of chronic myeloid leukaemia in a patient previously treated with radiotherapy for localized reticulum cell sarcoma.


Problems regarding the history of psychiatry.


DNA-strand breaks in two strains of Escherichia coli after exposure to  -rays.


The radiosensitivity of the bone-forming process of heterotopically-grafted rat bone-marrow.


Survival and DNA breakdown after gamma-irradiation in synchronously-growing Escherichia coli B.


Reinnervation of the reimplanted canine lung.


The distribution of 2,4-dinitrophenyl groups in guinea pig skin following surface application of 2,4-dinitrochlorobenzene: an immunofluorescent study.


Control of metabolism and synthesis of macromolecules in normal and ischemic heart.


A model and computer program for biological networks.


Insulin and the heart.

Insulin and the heart.


Retirement of Mr. J. H. Noldt.

Retirement of Mr. J. H. Noldt.


Mandrax: no significant side effects.

Mandrax: no significant side effects.


Serum lipid transport systems: recent advances.


Jonathan Martin, the York Minister incendiary. Historical note.


David Ernest Trumpy.

David Ernest Trumpy.


Diagnosis and management of common headache problems.


The shaking patient and advances in the therapy of Parkinsonism.


Infection of the central nervous system. Advances in treatment.


Recent advances in neurodiagnostic laboratory procedures. I. Electroencephalography, electromyography and echoencephalography.


Recent advances in neurodiagnostic laboratory procedures. II. Radioisotope studies.


Diagnostic approach to hemolytic anemias.


Hemolytic anemias associated with hemoglobinopathies.


The red cell membrane in hemolytic anemia.


Immune hemolytic anemias.

Immune hemolytic anemias.


Hemolytic anemias in infants and children.


Enzyme-deficient hemolytic anemias. Mechanisms, diagnosis and treatment.


Incisions, amputations, and skin grafting in the hand.


Local flaps for surgery of the hand.

Local flaps for surgery of the hand.


The distant pedicle flap in surgery of the hand.


Management of the burned hand.

Management of the burned hand.


Electrical and cold injuries of the hand.


Management of nerve injuries in the forearm and hand.


Reconstruction of the athlete's injured knee: anatomy, diagnosis, treatment.


Biochemical and metabolic aspects of osteoarthritis.


Biomechanical aspects of the hip joint.

Biomechanical aspects of the hip joint.


Osteotomy of the hip.

Osteotomy of the hip.


Replacement endoprostheses in the treatment of the damaged hip.


Further studies on the radioresistance of antibody producing cells: characterization of the survival curve.


Reduced production of spleen colonies and granulocytes in antibiotic-treated irradiated mice transplanted with syngeneic bone marrow.


Effect of gamma radiation on Serratia marcescens. Comparison of the radiosensitivity of pigmented and nonpigmented cells.


Effect of quinacrine on x-ray sensitivity and the repair of damaged DNA in Escherichia coli K-12.


The pagan roots of western hospitals.

The pagan roots of western hospitals.


Pulmonary artery-portal vein shunt and its surgical application.


Transcriptional regulation in mammalian chromosomes.


Cyclophosphamide and whole organ transplantation in human beings.


Information transfer between nucleus and cytoplasm during differentiation.


Hormonal regulation of metamorphosis.

Hormonal regulation of metamorphosis.


Control mechanisms of protein synthesis in the unfertilized egg and early development of sea urchins.


The control of enzyme formation in plants.


Inductive interactions in kidney development.


Extrinsic and intrinsic information transfer in early differentiation of amphibian embryos.


Control of form and pattern in the vertebrate limb.


Wall pattern formation in angiosperm microsporogenesis.


Some aspects of differentiation in plants.


Cell development in the cellular slime mould Dictyostelium discoideum.


Clonal basis of mammalian differentiation.


The design of the mouse blastocyst.

The design of the mouse blastocyst.


The organization of the insect segment.

The organization of the insect segment.


Positional information and pattern regulation in regeneration of hydra.


A model of early amphibian development.

A model of early amphibian development.


The scale of pattern formation.

The scale of pattern formation.


Models for the control of development.

Models for the control of development.


Organization of structure, synthesis and transport within the plant during cell division and growth.


Electron microscopy applied to the study of macromolecular components assembled to form complex biological structures.


Specificities in the structure and function of interphase chromosomes.


Aneurysm of the aortic arch.

Aneurysm of the aortic arch.


A new stereoencephalotome.

A new stereoencephalotome.


New chromatographic method for the separation of single-stranded DNA, double-stranded DNA and RNA.


Examination of laser-inactivation on T7 phages.


Whom do children believe?

Whom do children believe?


Anorexia nervosa. An illness of two generations?


Professor Sven Evert Donner.

Professor Sven Evert Donner.


Metabolism of 1,1,2,2-tetrachloroethane- 14 C in the mouse.


Metabolism of  14 C-pentachlorophenol in the mouse.


Studies of lymph in certain disorders of the liver, pancreas and small intestine.


Placebo gastric analysis.

Placebo gastric analysis.


The German contribution to the control of the major endemies in Africa.


History of the control of endemic diseases in the Netherlands Overseas Territories.


The British contribution to the fight against African trypanosomiasis.


Brief history of trypanosomiasis research in East Africa and the development of E.A.T.R.O.


The reactions of the sulfhydryl groups on the elongation factors Tu and Ts.


Physical characterization of deoxyribonucleic acids in Dictyostelium discoideum.


The effect of D 2 O substitution for H 2 O on the melting temperature of E. coli ribosomes.


Further studies on the role of factors Ts and Tu in protein synthesis.


A comparative study of the multiple forms of pig heart lipoyl dehydrogenase.


Methylcobalamin as a substrate at a separate site on Escherichia coli B N 5 -methyltetrahydrofolate-homocysteine cobalamin methyltransferase.


Studies on the structure of rabbit muscle aldolase. 3. Primary structure of the BrCN peptide containing the active site.


Disulfide bonds of pepsinogen and pepsin: identification of the disulfide bonds which can be reversibly reduced and reoxidized.


The inhibition of f2 RNA directed E. coli protein synthesis by poly rI-rC in vitro.


The ribosomal-RNA synthesis factor psi-r in Escherichia coli infected with RNA bacteriophage R23.


The control of ribonucleic acid synthesis in bacteria. The synthesis and stbility of ribonucleic acid in rifampicin-inhibited cultures of Escherichia coli. A study was made of the kinetics of labelling of the stable ribonucleic acids (rRNA+tRNA) and the unstable mRNA fraction in cultures of Escherichia coli M.R.E.600, inhibited by the addition of 0.1g of rifampicin/l. Labelling was carried out by adding either [2-(14)C]- or [5-(3)H]-uracil as an exogenous precursor of the cellular nucleic acids. From studies using DNA RNA hybridization, the kinetics of the synthesis and degradation of mRNA was followed in the inhibited cultures. Although a considerable proportion of the mRNA labelled in the presence of rifampicin decayed to non-hybridizable products, about 25% was stabilized beyond the point where protein synthesis had finally ceased. It therefore seems unwise to extrapolate the results of studies on mRNA stability in rifampicin-inhibited cultures to the situation existing in the rate of steady growth, where there appears to be little, if any, stable messenger. The kinetics of labelling of RNA in inhibited cultures indicated that the clapsed time from the addition of rifampicin to the point at which radioactivity no longer enters the total cellular ribonucleic acids is a measure of the time required to polymerize a molecule of rRNA. At 37 degrees C, in culture grown in broth, glucose-salts or lactate salts media, exogenous [2-(14)C]uracil entered rifampicin-inhibited cells and was incorporated into RNA for 2 3min after the antibiotic was added. Taking this time as that required to polymerize a complete chain of 23S rRNA, the polymerization rate of this fraction in the three media was 25, 22 and 19 nucleotides added/s to the growing chains. Similar experiments in cultures previously inhibited by 0.2g of chloramphenicol/l showed virtually identical behaviour. This confirmed the work of Midgley & Gray (1971), who, by a different approach, showed that the polymerization rate of rRNA in steadily growing and chloramphenicol-inhibited cultures of E. coli at 37 degrees C was essentially constant at about 22 nucleotides added/s. It was thus confirmed that the rate of polymerization of at least the rRNA fraction in E. coli is virtually unaffected by the nature of the growth medium and therefore by bacterial growth rate.


The control of ribonucleic acid synthesis in bacteria. The synthesis and stability of ribonucleic acid in chloramphenicol-inhibited cultures of Escherichia coli. The rate of polymerization of ribosomal ribonucleic acid chains was estimated for steadily growing cultures of Escherichia coli M.R.E.600, from the kinetics of incorporation of exogenous [5-(3)H]uracil into completed 23S rRNA molecules. The analytical method of Avery & Midgley (1971) was used. Measurements were made at 37 degrees C, in the presence or the absence of chloramphenicol, in each of three media; enriched broth, glucose-salts or sodium lactate-salts. The rate of chain elongation of 23S rRNA was virtually constant in all media at 37 degrees C, as 24+/-4 nucleotides added/s. Accelerations in the rate of biosynthesis of rRNA by chloramphenicol in growth-limiting media are due primarily to an increase in the rate of initiation of new RNA chains, up to the rates existing in cultures growing rapidly in broth. Thus, in poorer media, only a small fraction of the available DNA-dependent RNA polymerase molecules are active at any given instant, since the chain-initiation rate is limiting in these conditions. In cultures growing rapidly in enriched broth, antibiotic inhibition caused a rise of some 12% in the rate of incorporation of exogenous uracil into total RNA. This small acceleration was due entirely to the partial stabilization of the mRNA fraction, which accumulated as 14% of the RNA formed after the addition of chloramphenicol. In cultures growing more slowly in glucose-salts or lactate-salts media, chloramphenicol caused an immediate acceleration of two- to three-fold in the overall rate of RNA synthesis. Studies by DNA-RNA hybridization showed that the synthesis of mRNA was accelerated in harmony with the other affected species. However, just over half the mRNA formed after the addition of chloramphenicol quickly decayed to acid-soluble products, whereas the remainder was more stable and accumulated in the cells. The mRNA fraction constituted about 6% of the total cellular RNA after 3h inhibition. A model was suggested to explain the partial stabilization and accumulation of the mRNA fraction and the acceleration in the rate of synthesis of mRNA when chloramphenicol was added to cultures in growth-limiting media.


The inhibition of pepsin-catalysed reactions by structural and stereochemical product analogues. 1. The inhibition of pepsin-catalysed hydrolysis of N-acetyl-l-phenylalanyl-l-phenylalanylglycine by products and product analogues was studied. 2. Inhibitors of the l-configuration give rise to linear non-competitive inhibition, whereas those of the d-configuration show linear competitive behaviour. 3. Non-competitive inhibition by the product N-acetyl-l-phenylalanine indicates an ordered release of products, which supports a common mechanism (involving an ;amino-enzyme') for pepsin-catalysed transpeptidation and hydrolysis reactions. 4. The differences in the types of inhibition caused by product analogues of the l- and d-series emphasize the stereospecificity of the binding of these inhibitors to free enzyme and to the putative amino-enzyme intermediate. 5. The results suggest that it is the anion of the acyl product that is released first in the hydrolytic reaction (see Kitson & Knowles, 1971).


The pathway of pepsin-catalysed transpeptidation. Evidence for the reactive species being the anion of the acceptor molecule. 1. The inhibition of pepsin-catalysed hydrolysis of N-acetyl-l-phenylalanyl-l-phenylalanylglycine by the acyl product and product analogues was studied at pH4.3. 2. The acyl product, N-acetyl-l-phenylalanine, gives rise to linear competitive inhibition at pH4.3, whereas at pH2.1 it shows linear non-competitive behaviour. 3. The extent of transpeptidation to N-acetyl-l-[(3)H]phenylalanine during the pepsin-catalysed hydrolysis of N-acetyl-l-phenylalanyl-l-phenylalanyl-glycine is significant at pH4.7, but is undetectable at pH1.3. 4. Both the inhibition and transpeptidation experiments are consistent with the anion of the acceptor molecule being the substrate in pepsin-catalysed transpeptidation. This conclusion supports the formulation of pepsin-catalysed reactions put forward by Knowles et al. (1970).


Observations on the range of efficacy of L-dopa.


Peripheral influences on VPM-VPL thalamic nuclei in the human. A study on evoked potentials.


Somatomotor response in torticollis.

Somatomotor response in torticollis.


George K. Wharton, M.B., 1904-1971.

George K. Wharton, M.B., 1904-1971.


Evidence for an enterogastric reflex for the inhibition of acid secretion.


An experimental study of lasers as excitation sources for automated fluorescent antibody instrumentation.


Immunofluorescent detection of bacteria and proteins embedded in acrylamide gel.


Antibody-mediated suppression of the immune response: effect on the development of immunologic memory.


Antibody response in genetically thymus-less nude mice injected with normal thymus cells.


Studies on rabbit lymphocytes in vitro. XIV. Fractionation of rabbit peripheral blood lymphocytes by antibody-coated polyacrylamide beads.


Effect of blocking cell receptors on an immune response resulting from in vitro cooperation between thymocytes and thymus-independent cells.


Isolation of 7S IgM and kappa chains from the surface membrane of tissue culture cells derived from a Burkitt lymphoma.


Immunosuppression by leukemia viruses. VII. Stimulatory effects of Friend leukemia virus on pre-existing antibody-forming cells to sheep erythrocytes and Escherichia coli in non-immunized mice.


Bone marrow-derived cells as target cells for polynucleotide adjuvants.


7S IgM and IgA influenza fluorescent antibodies in serum.


Chemistry of cephalosporin antibiotics. 23. 2-Methyl- and 2-methylenecephalosporins.


Effect of 2-anilinopyridines on protein synthesis.


A stable, biologically active indoxyl.

A stable, biologically active indoxyl.


Synthetic trypanocides. 2. Substituted 5,6-dihydro(c)benzocarbazoles.


An improved synthesis of diaveridine, trimethoprim, and closely related 2,4-diaminopyrimidines.


Nomarski Differential Interference Contrast of the normal and pathologic guinea pig organ of Corti.


Tympanoplasty: areolar tissue graft.

Tympanoplasty: areolar tissue graft.


Function of the rel gene in Escherichia coli.


Permeability of the skin.

Permeability of the skin.


Morphology, histochemistry, and biochemistry of human ovarian compartments and steroid hormone synthesis.


On the usefulness of the placebo and of the double-blind technique in the evaluation of psychotropic drugs.


Early clinical drug evaluation units reports.


Electrophysiological investigations on the pigeon's optic tectum.


The effect of positive pressure breathing on the cerebral circulation and the content of catecholamines in hypothalamus and adrenals.


Water cooled garments: a review.

Water cooled garments: a review.


Vascular dynamics. Impedance plethysmograph study during a standardized tilt table procedure.


Ultrastructural study of calcium distribution in cardiac muscle cells.


Biometric analyses of normal skeletal muscle.


Classic pages in obstetrics and gynecology. Joe Vincent Meigs and John W. Cass. Fibroma of the ovary with ascites and hydrothorax. With a report of seven cases.


Glucose and intestinal absorption in man.


Surgical treatment of gastric ulcer.

Surgical treatment of gastric ulcer.


The transverse strength of repairs in polymethyl methacrylate.


Aetiology of transient neonatal diabetes.


Fluoride ion release from dentifrices and caries inhibition in a clinical trial.


Bruxism: the changing situation.

Bruxism: the changing situation.


Origins of hypodermic medication.

Origins of hypodermic medication.


Harry Taylor Hardy.

Harry Taylor Hardy.


Complications of urinary drainage following renal transplantation.


Differential efferent projections from the ventral and dorsal hippocampus of the cat.


The organization of the thalamo-cortical visual pathways in the cat. An experimental degeneration study.


Endoskeletal structures for lower-extremity prostheses.


Cerebello-pontine reverbearating circuit.


Variants of the PTB (patellar-tendon-bearing) below-knee prosthesis.


1945-1970--and then?

1945-1970--and then?


Veterans Administration Prosthetics Center research report.


The Veterans Administration's standards program in prosthetics, orthotics, and orthopedic aids.


Development and evaluation of externally powered upper-limb prosthesis. Summary of research project activities July 1, 1959--December 31, 1959.


Prosthetic parallelometer.

Prosthetic parallelometer.


New license rule for nursing home administrators.


Bibliography, perceptions of aging.

Bibliography, perceptions of aging.


Social security chief looks at medicare future.


Perceptions of old people: a review of research methodologies and findings.


Vascular tumors of bone.

Vascular tumors of bone.


The automation of clinical diagnosis.

The automation of clinical diagnosis.


The extractable pancreatic insulin content and histopathology of islets of Langerhans in diabetics.


The old pathology building--Hoosier medicine's "little red schoolhouse".


Caries prevention through sealing of pits and fissures.


Biomedical engineering in an historical setting.


A double-blind trial of a new anti-inflammatory drug in the management of osteo-arthritis of the hip-joint.


Physicians services and the intermediate care facility.


The early days of MAG.

The early days of MAG.


The Borden Award. Dr. Joseph Willis Beard.


The Abraham Flexner award. Dr. Carl V. Moore.


Lipid metabolism in the rabbit choroid plexus.


Sources of gamma camera image inequalities.


Analytical approach to dynamic radioisotope recording.


Physician-computer interaction as a clinical research technique.


Plastic draping materials.

Plastic draping materials.


Renal vein thrombosis distal to patent splenorenal shunt.


An epidemic of chronic skin ulceration in rats.


Some common parasites of small laboratory animals.


The effect on rabbit intestinal microflora of diets which influence serum cholesterol levels.


Cardiac surgery past and present.

Cardiac surgery past and present.


Cytotoxic therapy in rheumatoid disease.


The disputed value of fluoride given during pregnancy.


Michael Schneider.

Michael Schneider.


George Palmai.

George Palmai.


Gerschwin--his last six months.

Gerschwin--his last six months.


The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with the myeloproliferative syndrome.


Heart failure in valvular heart disease.


Body composition in cerebral palsy.

Body composition in cerebral palsy.


Gold posts. Common problems in preparation and technique for fabrication.


Current concepts of endodontic treatment for teeth with incompletely formed apices: a literature review.


Usher Parsons, M.D. [1788-1868]: naval surgeon in Battle of Lake Erie.


Paul Gerson Unna, M.D. [1850-1929]: Pioneer dermatologist and creator of modern dermatopathology.


Charles John Gates.

Charles John Gates.


Ira James Cunningham.

Ira James Cunningham.


Wm. C. Barry, M.R.C.V.S.

Wm. C. Barry, M.R.C.V.S.


Photobiological effects of metal ions. Photosensitizing action of uranyl acetate on Escherichia coli K-12.


Documentation of our past.

Documentation of our past.


Effect of thyroid hormone on stored kidney preservation for further transplant.


Effect of neonatal thymectomy and antithymocytic serum on susceptibility of rats to mycobacterium leprae infection.


Corticosteroids in endotoxic shock.

Corticosteroids in endotoxic shock.


Bone marrow repopulation of subcutaneously grafted mouse femurs.


Immunologic responses of neonatally thymectomized rats to sheep red blood cells and to flagellin from Salmonella adepaide.


How to track bacteria.

How to track bacteria.


Treatment of diffuse toxic goiter with 131-I.


The effect of pregnancy on rejection of allotransplanted hearts in the rabbit and rat.


The phagocytic activity of polymorphonuclear leucocytes from germfree and conventional rats.


Cytomorphometry of skeletal muscle: the influence of age and testosterone on the rat m. levator ani.


Henry C. Schumacher. Born July 6, 1893; died February 14, 1971. President, American Orthopsychiatric Association, 1942-43.


An improved method of counting radioactive acrylamide gels.


Autoradiographic method for characterization of DNA and RNA polymerases after gel electrophoresis.


Fractionation by column chromatography in aqueous methanol of partial Ustilago sphaerogena nuclease digests of RNA.


Freeze-etch observations of rat lung.

Freeze-etch observations of rat lung.


Effects of cyclophosphamide on lesions induced by persistent LCM virus infection in gnotobiotic mice.


Half-of-the-sites reactivity and the conformational states of cytidine triphosphate synthetase.


Cytidine triphosphate synthetase. Covalent intermediates and mechanisms of action.


The carbohydrate composition of immunoglobulins G.


Vitamin B 12  and methionine synthesis in Escherichia coli.


Exploration of site(s) of action of progesterone in inhibiting ovulation in rats.


Temperature dependence of the aminoacylation of tRNA by Bacillus stearothermophilus aminoacyl-tRNA synthetases.


Sugar intake and coronary heart disease.


Sucrose in the diet and coronary heart disease.


Tendon lacerations of the hands (case P75).


The determination of inorganic sulfate by an isotope dilution technique.


Molecular genetics and developmental biology.


Immune responses after intralymphatic injection of  32 P-chromium phosphate in the dog.


Prolonged survival of skin allografts after treatment with direct current.


Preliminary experiments of canine isolated lung perfusion for storage.


An apparatus for hypothermic perfusion of isolated kidneys.


Ludwik Komczyński.

Ludwik Komczyński.


In memoriam Josif Abramovitch Kassirsky 1898-1971.


Leonard Colebrook. Reminiscences on the occasion of the 25th anniversary of the Birmingham Burns Unit.


Subcortical cancellous bone-grafting (Phemister-Charnley) in the treatment of delayed union. An experimental study on dogs.


Anterior fusion for fractures and dislocations of the cervical spine.


Analogs of respiratory mechanics.

Analogs of respiratory mechanics.


The use of analogs in the teaching of the pharmacokinetics of the inhalation anesthetic agents.


Miscellaneous analogs: pharmacokinetics, cardiovascular system, respiratory system.


Possible impact of government drug program on community pharmacies.


A method for studying antibiotic concentrations in inflammatory exudate. A new technique is described for studying antibiotic concentrations in an experimental inflammatory exudate in vivo. In most exudates concentrations of four antistaphylococcal drugs which were of potential therapeutic significance could be assayed, and fucidin appeared to diffuse best. Higher concentrations of all antibiotics gained access to the lesion in the first two hours of inflammation, suggesting that their mobility did not depend on binding to cells during the inflammatory response. The technique may ultimately help to elucidate the relationship between antibiotics and host defences at the primary sites of infection.


Immunofluorescent staining of rat gastric parietal cells.


Colicine types of Shigella sonnei isolated in Hong Kong. Two-hundred and twenty-five strains of Shigella sonnei isolated from sporadic cases of bacillary dysentery were subjected to colicine typing. The result showed that types 15 and 12 were the prevailing types in Hong Kong and two new types which did not fit in with the colicine patterns of the current types were observed. A marked increase in the numbers of strains concurrently resistant to chloramphenicol, tetracycline, and streptomycin occurred in recent years. However, there was no correlation between drug resistance or biochemical pattern and colicine types. Consistency of colicinogenicity was confirmed by the fact that even a rough variant of a smooth strain had not changed its colicine pattern.


The Franck Drawing Completion Test as a measure of creativity.


Brain acyl-coenzyme A hydrolase: distribution, purification and properties.


Effect of tranexamic acid (AMCA) in menorrhagia with intrauterine contraceptive devices.


Chronic viral infections of the central nervous system.


Medical education in the United States. 1970-1971. VII. Programs in medical education sponsored by government agencies.


Privileged communication after death.

Privileged communication after death.


The "David" of Michelangelo or (why the foreskin?).


Autoantibody-secreting plaque forming cells in spleen and thymus of NZB and normal mice.


Induction of "low dose" tolerance to a bacterial somatic antigen in neonatal mice.


Vascular surgery. A decade of progress.

Vascular surgery. A decade of progress.


Medicare requires more detailed itemization of claims before payment.


The commercial exploitation of seaweeds, with special reference to alginate manufacture.


Portal hypertension in childhood. A study of 24 cases.


Spontaneous perforations of the biliary tract in infancy.


Infantile pyloric stenosis. Historical aspects and current surgical concepts.


The small kidney.

The small kidney.


The use of synthetic polymeric materials as suture substitutes and their place in pediatric surgery.


Serratia marcescens septicemia complicating splenectomy in a child.


Current status of chemical studies on the origin of life.


Effect of local cooling on the fine structure of the cerebral and cerebellar cortex.


Effect of septal lesion on exploratory activity, passive avoidance learning and pituitary-adrenal function in the rat.


Variations in the metal content of some commercial media and their effect on microbial growth. The cation content in commercial media obtained from two manufacturers showed considerable variation. Even different batches of the same make were found to be inconsistent in the content of metal ions. With cultures of Cytophaga sp. and Yersinia pseudotuberculosis in base media, growth stimulation was dependent on additions of certain commercial media. It could be demonstrated that this stimulation was derived solely from increased Mg(2+) concentration in the media.


Evaluation of accuracy of multitest micromethod system for identification of Enterobacteriaceae. The Analytab system of 20 biochemical tests for identification of Enterobacteriaceae was evaluated in parallel with conventional tests on 128 Enterobacteriaceae, 5 Aeromonas, and 1 Yersinia enterocolitica. The results of tests for H(2)S and indole production, citrate utilization, lysine and ornithine decarboxylase, arginine dihydrolase, nitrate reduction, beta-galactosidase, and fermentation of arabinose, rhamnose, mannitol, and glucose showed almost complete agreement between the two systems. Eighty-eight per cent of Enterobacteriaceae were correctly speciated with the Analytab system; on repeat testing with heavier inocula of organisms failing to ferment glucose initially, the proportion of Enterobacteriaceae correctly speciated became 93%.


False-positive anti-Toxoplasma fluorescent-antibody tests in patients with antinuclear antibodies. The indirect fluorescent-antibody (IFA) method for diagnosis of toxoplasmosis is widely used and is considered to be as specific as the Sabin-Feldman dye test. After observing a patient with systemic lupus erythematosus (SLE) who had a positive toxoplasma IFA test but a negative dye test, we studied sera with high titers of antinuclear antibodies from 16 SLE patients and from 2 with rheumatoid arthritis for Toxoplasma antibodies in the immunoglobulin G and M (IgG and IgM) IFA tests and the dye test. Results of these tests were compared with titers of antinuclear antibodies, precipitating antibodies to single-strand deoxyribonucleic acid (DNA), and binding antibodies by use of DNA labeled with (3)H-actinomycin D. Of 18 patients, 11 had IgG and 4 had IgM IFA Toxoplasma antibodies; only 2 had antibodies detectable in the dye test. The immunofluorescence patterns in the Toxoplasma IFA test were indistinguishable from those obtained in patients with toxoplasmosis without antinuclear antibodies. Absorption of SLE sera with DNA did not result in a decrease in Toxoplasma IFA titers. When SLE sera were absorbed with live T. gondii, a marked drop in IgG IFA titer was observed as well as a decrease in titers of antinuclear antibodies and (3)H-DNA binding. Treatment of Toxoplasma cells with deoxyribonuclease and ribonuclease did not decrease their fluorescence. These results suggest that T. gondii nuclear antigens can absorb antinuclear antibodies but do not have exposed substrates for deoxyribonuclease. Tests in which organisms containing "nuclear" antigens for IFA detection of antibodies to these organisms are used may result in "false-positives" with sera containing antinuclear antibodies.


Scopafungin, a crystalline antibiotic produced by Streptomyces hygroscopicus var. enhygrus var. nova. Scopafungin (U-29,479) is a crystalline, nonpolyenic antimicrobial agent obtained from the culture broth of Streptomyces hygroscopicus var. enhygrus var. nova UC-2397. Scopafungin inhibits, in vitro, a variety of pathogenic fungi, yeasts, and gram-positive bacteria.


Characterization of an unusual strain of proteus rettgeri associated with an outbreak of nosocomial urinary-tract infection. An outbreak of nosocomial urinary-tract infection was caused by a strain of Proteus rettgeri that fermented lactose overnight and was resistant to all antimicrobial drugs tested. The nonmotile isolates shared an O (somatic) antigen that differed from those of wild-type P. rettgeri. The organisms proved markedly serum-sensitive. In rats, the isolates elicited an acute interstitial nephritis with associated transient bacteriuria. Attempts to transfer the lac(+) trait and drug-resistance markers to recipient strains of Escherichia coli K-12 failed; exposure of the isolates to acridine orange yielded small numbers of non-lactose-fermenting variants which, however, were still as drug-resistant as before. Epidemiological studies failed to uncover the source of this unique strain and appeared to indicate exogenous spread of infection.


Soft-shell clam, Mya arenaria, a convenient laboratory animal for screening pathogens of bivalve mollusks. Attempts to introduce infectious or foreign material into oysters and other bivalve mollusks usually involve force or trauma because of immediate, prolonged adduction of the tightly closing valves. The soft-shell clam, Mya arenaria, is unable to seal its valves completely and relaxes readily, exposing soft tissue and a large siphon. This species is free from fouling organisms and is readily available at all seasons in the New England and mid-Atlantic areas. Suspensions of five strains of Vibrio sp. that cause bacillary necrosis in larval and juvenile bivalve mollusks were injected into the heart, siphon tissue, and the incurrent and excurrent siphon lumina of soft-shell clams. All vibrio strains caused significant mortality, usually within 2 days. Heaviest losses resulted from heart and excurrent siphon injections. No mortality occurred in control clams injected with seawater, broth, Serratia sp., and Escherichia coli. The soft-shell clam appears to be a useful animal for testing the pathogenicity of marine microorganisms for bivalve mollusks.


Two-tube test for the rapid identification of prompt lactose-fermenting genera within the family Enterobacteriaceae. One hundred and fifty-nine prompt lactose-fermenting strains of Enterobacteriaceae were tested for H(2)S production, ornithine decarboxylase activity, motility, and citrate utilization by using two different sets of test media. It was shown that the three tests first mentioned could be carried out in a single tube, the results being as reliable as when each was done separately. Simmons medium was preferred for the detection of citrate utilization. Since these four tests require only two tubes, they are considered more convenient in routine diagnostics. A combined medium for the detection of H(2)S production and motility is described.


Monitoring of low-level virus in natural waters. The insoluble polyelectrolyte technique for concentrating virus is extended to extremely low virus levels. The effectiveness of this method employing a coliphage T2 model is a constant 20% over a range of virus levels from 10(3) to 10(-4) plaque-forming units/ml. The efficiency of the method is dependent upon pH control during the concentration phase. Although the study was initiated to develop a method for quantitating the effectiveness of water and wastewater treatment methods for the removal of viruses from waters at low concentrations, the potential of the technique for efficient monitoring of natural waters is apparent.


Effect of plate size and location of disc on zone diameter in the disc antimicrobial susceptibility test. An established standard antimicrobial disc susceptibility test recommends the use of a 150-mm petri dish. Many workers substitute 100-mm plates and use various types of mechanical dispensers. A comparison of zone diameters was made by testing Staphylococcus aureus and Escherichia coli against penicillin and chloramphenicol with the use of these different sized plates and dispensers. Zone diameters were consistently smaller at the edges of plates than in the center (0.4 to 1.2 mm). Significant small differences of up to 1.2 mm or no differences were observed when the mean diameters from these various plates were compared. All of the zone diameter measurements fell within accepted values for analytical variability in this procedure. There is no evidence that any individual combination of plates, dispensers, or disc locations provides greater precision in zone diameter measurement. More difficulty was encountered in measuring zones at the periphery of small plates. This suggests that busy clinical laboratory workers might not produce work of comparable quality with the smaller plates.


Specific distribution of R factors in Serratia marcescens strains isolated from hospital infections. Serratia marcescens strains from three hospitals in the city of New York were tested for antibiotic susceptibility patterns and the presence of transmissible antibiotic resistance factors. There appears to be a pattern characteristic for each hospital with regard to the sensitivity to nalidixic acid, tetracycline, chloramphenicol, and sulfonamides, whereas the resistance to ampicillin, cephalothin, and streptomycin is similar in the strains isolated from all three hospitals. In one hospital, a single type of R factor was found which transfers resistance to streptomycin, kanamycin, ampicillin, and sulfonamides, whereas strains isolated from a second hospital transfer only ampicillin resistance. No R factors could be detected in multiply resistant Serratia strains isolated in a third hospital. The presence of a single type of R factor probably reflects the relative ecological isolation of S. marcescens and could be useful for epidemiological studies of hospital infections with Serratia.


Quantitative nasal culture: a tool in antibiotic research. The use of the quantitative nasal culture was investigated as a means of evaluation of new antimicrobial drugs in man. Cyclacillin was somewhat more active in vitro than penicillin G against penicillin G-resistant organisms. Cyclacillin was highly effective in suppressing staphylococci susceptible to penicillin G in nasal carriers but did not suppress staphylococci resistant to penicillin G. Although in previous studies by others cyclacillin was effective in treating mice infected with penicillin G-resistant staphylococci, in the present studies cyclacillin was not effective in suppressing nasal penicillin G-resistant staphylococci in man at doses which markedly suppressed penicillin G-sensitive organisms.


Bacteriology of dehydrated space foods.

Bacteriology of dehydrated space foods. The initial bacteriological requirement established in 1964 for space foods by the U.S. Army Natick Laboratories are: a total aerobic plate count (</= 10,000 per g), a total coliform count (</= 10 per g), fecal coliforms (negative per gram), fecal streptococci (</= 20 per g), coagulase-positive staphylococci (negative in 5 g) and salmonellae (negative in 10 g). Of the space foods and prototypes tested during 1968 and 1969, 93% complied with the total aerobic plate count, 98% had less than 1 coliform per g, and 99% were negative for fecal coliforms; 88% complied with the streptococci requirement; 100 and 98% were negative for staphylococci and salmonellae, respectively. Nineteen food samples which did not comply (as indicated parenthetically by actual counts per gram) with the requirements were (i) total aerobic plate count: beef soup and gravy base (18,000), chicken soup and gravy base (57,000), spaghetti with meat sauce (12,100 and 14,000), sugared coffee (> 300,000), chocolate ice cream cubes (20,000), and each of four samples of chocolate candy (12,000 to 61,000); (ii) coliforms: two out of three vanilla milk drinks (16 and 127) and one beef hash bar (14); (iii) fecal coliforms: one sample of chicken soup and gravy base positive; (iv) fecal streptococci: two samples of peanut cubes (40 and 108), coconut cubes (75), chicken soup and gravy base (2,650), beef soup and gravy base (33), and five out of six flavored milk drinks (23 to 300); (v) salmonellae: one each of chicken and beef soup and gravy base were positive.


Control of contamination in psittacosis specimens by antibiotics. Diluent containing a combination of vancomycin, kanamycin, and streptomycin is shown to be more effective than diluent previously used for isolating Chlamydia psittaci from bird tissue specimens.


Multi-biochemical test system for distinguishing enteric and other gram-negative bacilli. A multi-biochemical test system consisting of nine tests, entitled Enterotube, was evaluated in parallel with conventional tests to determine its value in the identification of enteric and certain other gram-negative bacilli. The 242 bacterial strains studied were from a variety of pathological specimens and from our culture collection. When the results with individual tests represented in both test systems were compared, no discrepancies were noted in the indole test, and one discrepancy was recorded for dextrose. In 7 of 242 hydrogen sulfide tests, 3 of 242 phenylalanine tests, 22 of 242 urease tests, 15 of 242 dulcitol tests, 12 of 242 lactose tests, 27 of 217 lysine decarboxylase tests, and 5 of 242 citrate tests, the Enterotube results were contrary to those obtained with conventional methods. The lysine decarboxylase test in the Enterotube posed a problem of interpretation and readability and is not an acceptable alternative to the conventional methods. Fifteen of the strains studied were incorrectly identified by the Enterotube system and four could not be differentiated from other closely related strains. Salmonella could be identified as to group, whereas Shigella strains were frequently misidentified as Escherichia. The Enterotube method is simple and convenient, and all media are inoculated at once from a single colony.


Mechanical method of inoculating plates for antibiotic sensitivity testing. A mechanical method of inoculating culture plates for antibiotic sensitivity testing is described. This method, which involves the use of a modified laboratory centrifuge, is rapid and provides a homogeneous distribution of organisms.


Inhibition of gastric motility by endotoxin (bacterial lipopolysaccharide) in conscious goats and modification of this response by splanchnectomy, adrenalectomy or adrenergic blocking agents.


Changes in the diagnostic process during 40 years of clinicopathologic conferences.


Current studies regarding diabetes.

Current studies regarding diabetes.


Hybridization of membranes by sonic irradiation.


The use of quantitative immunofluorescence to measure immunoglobulin levels in mouse myleoma cells during the cell cycle.


Differential sensitivity of haemolytic plaque methods at various stages of the immune response.


The bronchodilator effects of orciprenaline and salbutamol: a double-blind study.


Site of airway closure in dog lungs.

Site of airway closure in dog lungs.


Incidence of cells simultaneously secreting IgM and IgG antibody to sheep erythrocytes.


Cytotoxic interaction of phytohemagglutinin-stimulated blood lymphocytes with monolayer cells: a study by light and electron microscopy.


Reconstitution of the T-cell pool after irradiation of mice.


Method for evaluation of systemic to pulmonary artery pre-capillary shunts.


For exercise testing, please. A review of procedures available to the clinician.


Microsurgery.

Microsurgery.


Hemorrhagic shock.

Hemorrhagic shock.


Renal transplantation.

Renal transplantation.


Structural effects on blood proteins at the gas-blood interface.


Platelet adhesion to artificial surfaces: consequences of flow, exposure time, blood condition, and surface nature.


Role of an artificial boundary in modifying blood proteins.


Addition of nucleotides to parental DNA early in infection by bacteriophage T4.


Role of deoxynucleotide strand age or polarity in determining asymmetric chromosome replication after thymine starvation of Escherichia coli 15T - .


Certain aspects of blood interfacial phenomena--red blood cells.


Biochemistry of DNA-defective amber mutants of bacteriophage T4. II. Intracellular DNA forms in infection by gene 44 mutants.


Physical studies of ribosomes from Escherichia coli.


Purification of initiator C from Escherichia coli: a protein which binds messenger RNA and initiator tRNA to the 30 s ribosome.


Vomiting frequency in children administered nitrous oxide-oxygen in analgesic doses.


Miscoding caused by 5-fluorouracil.

Miscoding caused by 5-fluorouracil.


Calcifying epithelial odontogenic tumor: report of case and review of literature.


Familial dysautonomia: a case report.

Familial dysautonomia: a case report.


Bilateral nephrectomy: its role in management of the malignant hypertension of end-stage renal disease.


Renal emphysema and retention of renal function.


The transplantation of a cadaver kidney with ureteral duplication: a case report.


Speech problems in children.

Speech problems in children.


The public interest and the dental profession.


Isolation of corynebacteria from non-specific urethritis.


Intraoral bacterial changes with various pedodontic-orthodontic appliances.


T-even bacteriophage-tolerant mutants of Escherichia coli B. II. Nucleic acid metabolism. T-even bacteriophage-tolerant mutants are strains of Escherichia coli which can adsorb T-even phages but cannot support the growth of infective virus. Under some conditions, the infected cells are not killed. Mutant cells infected by phage T6 are able to carry out several metabolic functions associated with normal virus development, including arrest of bacterial nucleic acid and protein synthesis, incorporation of isotopic precursors into viral nucleic acids and proteins, synthesis of early enzymes of deoxyribonucleic acid (DNA) metabolism, formation of rapidly sedimenting DNA intermediates, and formation of normal levels of early and late messenger ribonucleic acid species. Phage are unable to mutate to forms capable of growth on these mutants. The nature of the biochemical alteration leading to tolerance is still unknown.


Effect of rifampin on the development of ribonucleic acid bacteriophage Q . The drug rifampin, when added at the time of infection, inhibits synthesis of the phage Qbeta. Both viral ribonucleic acids and viral proteins are made in nearly the same amount as in the absence of rifampin, but the rate of assembly into phage particles is low.