Development of an originality scale for the Franck Drawing Completion Test.


Obese individuals' perception of body image.


The initialmanagement of ureteral injuries: a report f 78 cases.


Simplified operation for stress incontinence.


Clyde Leroy Deming 1885-1969.

Clyde Leroy Deming 1885-1969.


Experience with arteriovenous fistula in chronic hemodialysis.


The saphenous vein bypas graft in the treatment of renovascular hypertension.


Henry Oliver Mertz 1884-1969.

Henry Oliver Mertz 1884-1969.


Evaluation of the scrotal inlay procedure (Turner-Warwick) for strictures of the deep urethra.


Presentation of Barringer Medal to Dr. Victor F. Marshall.


Summary of recent abstracts. IX. Helminthiasis.


The role of slow-reacting substance in asthma.


Studies of hepatic blood flow and hepatic function after ligation of the hepatic artery and portal vein.


Inverted versus everted gastrointestinal anastomoses: the role of the everted mucosa in anastomotic breakdown.


Functional and angiographic vasculature in healing wounds.


Immunologic response, virus excretion, and joint reactions with rubella vaccine. A study of adolescent girls and young women given live attenuated virus vaccine (HPV-77:DE-5).


Improved 18-hour methyl red test.

Improved 18-hour methyl red test. Standard methods for the methyl red (MR) test are not practical for routine use in clinical laboratories because of the necessarily prolonged incubation period. When read after overnight incubation, the usual MR test is often equivocal or falsely positive. The present study demonstrates the importance of standardizing the total volume of broth, the size of the vessel in which the cultures are incubated, and the density of the inoculum. In very small volumes of broth, cultures are better exposed to atmospheric oxygen, and thus MR-negative organisms tend to revert the initial acidic pH much more quickly than in deeper, large-volume broth cultures. In the proposed technique, a single colony was inoculated into a 0.5-ml amount of MR-Voges Proskauer (VP) broth (13- by 100-mm tube), and, after 18 to 24 hr at 37 C, one drop of MR was added. With this technique, the broth cultures produced either a definite red (positive) or yellow (negative) color, whereas various shades of orange were frequently observed when larger volumes of broth were tested after only 1 to 2 days of incubation. With 6.0-ml broth cultures, 18-hr MR tests were totally unreliable, but 18-hr tests in 0.5 ml of broth were comparable to the standard MR test performed after 5 days of incubation and superior to those performed after 48 hr in 6.0-ml broth cultures. With the proposed technique, the MR test can be incorporated readily into the routine scheme for identification of Enterobacteriaceae.


Infectious complications after cardiac transplantation in man.


Identification of members of the family Enterobacteriaceae by the R-B system. The R-B system was evaluated in parallel with conventional bacteriological procedures for the identification of members of the family Enterobacteriaceae by using bacterial strains from a variety of clinical specimens and from stock cultures. The R-B tests found to be reliable were, in decreasing order, the reactions for phenylalanine deaminase, hydrogen sulfide, and indole, the production of gas from glucose, and the decarboxylation of ornithine. The reactions in the R-B system found to be unreliable were motility, the decarboxylation of lysine, and the fermentation of both glucose and lactose. In addition, the reactions of the R-B system were more difficult to read and interpret than those of the conventional system. On the basis of this evaluation, it was concluded that the R-B system is not an acceptable alternative to the conventional methods in the identification of the Enterobacteriaceae.


One-day fluorescent-antibody procedure for detecting salmonellae in frozen and dried foods. The indirect fluorescent-antibody technique was used to examine 422 food samples for the presence of salmonellae. A cultural phase involving a 16-hr preenrichment in buffered nutrient broth-milk medium followed by a 4- to 5-hr subculture into fresh medium of the same composition was evaluated. This procedure yielded a sufficient population of salmonellae so that no false-negative results were obtained. Of the 31 false-positives obtained, 12 samples yielded positive cultural results upon extensive subculture of the original enrichment broths. Yeast cells and both vegetative and spore forms of bacilli were observed to fluoresce when stained with anti-Salmonella serum. Efforts to ascertain the cause of these cross-reactions and several alternate explanations are discussed.


Inhibitory action of tetrathionate enrichment broth. Tetrathionate enrichment broth is a complex mixture of salts including iodides and other polythionates, but only thiosulfate (0.0736 m) and tetrathionate (0.0236 m) in combination were toxic for Escherichia coli. Individually, these two salts were not lethal. The lethal action of this thiosulfate-tetrathionate mixture affected only growing cells. A possible relationship between the lethality of the thiosulfate-tetrathionate mixture for a culture and its ability to reduce tetrathionate is suggested.


Method for the isolation of proteolytic marine bacteria. A two-layer plate consisting of a lower indicator layer of milk-agar and an upper nutrient agar layer was developed for isolating proteolytic marine bacteria.


Effect of glucose and low oxygen tension on L-asparaginase production by a strain of Escherichia coli B. Cultural and nutritional requirements for maximum l-asparaginase synthesis were determined. Conventional aerobic and anaerobic fermentations were not satisfactory. The former yielded larger quantities of cells containing minimal amounts of l-asparaginase, whereas the latter supplied only minute amounts of bacteria that contained an abundance of enzyme. However, the combination of these classical methods, i.e., allowing growth to proceed aerobically until the mid to late exponential phase and then forcing the facultative microbial cells toward anaerobic metabolism by static incubation, produced 2.6 international units of enzyme per ml of fermentation broth when glucose was present. Enzyme synthesis was not induced by terminating aeration-agitation in the absence of glucose, nor was it induced in the presence of glucose when aeration was continued. Use of 0.2 m phosphate buffer resulted in a constant pH near the optimum value of 7.5 during l-asparaginase formation. Addition of 0.05% l-asparagine prior to induction was also beneficial, but other amino acids or their catabolites failed to increase biosynthesis of l-asparaginase.


Studies in uveal physiology. II. Clinical studies of the anterior chamber clearance of isotopic tracers.


Phosphenes resulting from stimulation of the midbrain in man.


The first ophthalmoscope? Adolf Kussmaul 1845.


Pharmacology and toxicology of ophthalmic drugs.


The development of crystallographic enzymology.


Intermediary metabolism of animal tissue between 1911 and 1969.


A retrospect on liquid chromatography.

A retrospect on liquid chromatography.


Methods for determining sequences in RNA.


he development of gas-liquid chromatography.


The primary structure of proteins.

The primary structure of proteins.


Some remarks on the history of molecular biology.


A comparison of analgesic therapies for the relief of acute otalgia.


Autoantibodies in dermatitis herpetiformis.


Fibrinolytic activity in lesions produced by monochromator ultraviolet irradiation in various photodermatoses.


History of dermatology in Northern Ireland.


Indirect immunofluorescence technique as compared with other methods for investigating the renal carrier state of leptospira in pigs.


Degradation of endotoxin by Salmonella typhimurium.


Quantitative studies of haemopoietic spleen colonies in rats treated with cytotoxic chemicals.


A controlled trial of oral contraceptives in haemophilia.


[Comparative studies of 5 BCG substranins. I. Residual virulence of the French, Soviet, Swedish, Japanese and Rumanian substrains].


The degradation of lignin and quantitative aspects of ruminant digestion.


External arteriovenous shunts for intermittent long-term hemodialysis: five years' experience.


Malignant tumours following immunosuppressive therapy. Two cases of malignant disease occurring during immunosuppressive therapy, one a leiomyosarcoma of bowel metastatic to the liver, the other, carcinoma in situ of the cervix uteri, are reported. The possible roles of immunosuppression and immunosuppressive therapy in the pathogenesis of these neoplasms are discussed. It is suggested that the incidence of neoplasms in immunologically suppressed patients is greatly increased and that further investigation into the relation of immunosuppression to cancer is urgently needed.


Atrial septal defect in the older patient. A clinical and hemodynamic study in patients operated on after age 35.


Left ventricular pressure-volume alterations and regional disorders of contraction during myocardial ischemia induced by atrial pacing.


The regulation of cerebral blood circulation in subclavian steal syndrome.


Regression of body compositional abnormalities of heart failure after intracardiac operations.


IgG immunoglobulin in the wall of post-capillary venules: possible relationship to lymphocyte recirculation.


The induction of haemolysin producing cells in vitro: inhibition by antiglobulin antisera.


Do we need a new way to treat diabetes mellitus?


Personality correlates of DAP facial expression.


Discrepancies in estimates of children's intelligence: WISC and human figure drawings.


Philip Harold Jones, MD, PhD, 1896-1970.


Repair of radiation-induced damage in Escherichia coli. I. Effect of rec mutations on post-replication repair of damage due to ultraviolet radiation.


Ribosomal protein synthesis during amino acid starvation and chloramphenicol treatment.


Vitamins.

Vitamins.


Tryptophan messenger ribonucleic acid elongation rates and steady-state levels of tryptophan operon enzymes under various growth conditions.


Charing Cross Hospital--yesterday and tomorrow.


Control of synthesis of glucosyl transferase and lysozyme messengers after T4 infection.


Marker-specific effects in genetic recombination.


Cell-free synthesis of bacteriophage T4 glucosyl transferase.


Evidence for the order promoter-operator-first structural gene in the tryptophan operon of Salmonella.


Effects of amino acid starvation on constitutive tryptophan messenger ribonucleic acid synthesis.


Uncoupling of late transcription from DNA replication in bacteriophage T4 development.


Assembly of bacteriophage T4 tail fibers. II. Isolation and characterization of tail fiber precursors.


More mutant tyrosine transfer ribonucleic acids.


Biosynthesis and distribution of ribosomal particles in the cellular slime mould, Dictyostelium purpureum.


Coupling of late transcription to viral replication in bacteriophage T4 development.


The development of the college journal.

The development of the college journal.


The story of two stethoscopes.

The story of two stethoscopes.


Some historical notes on indecent exposure and exhibitionism.


Lupus erythematosus and herpes zoster.

Lupus erythematosus and herpes zoster.


Prognosis of stage I lymphosarcoma and reticulum-cell sarcoma.


Septicemia from intravenous infusions.

Septicemia from intravenous infusions.


Right ovarian vein syndrome.

Right ovarian vein syndrome.


Dr. Paul Kimmelstiel.

Dr. Paul Kimmelstiel.


Replication of influenza A virus in suspensions of Ehrlich ascites tumor cells kept in vitro. Results obtained by the fluorescent antibody technique.


Assessment of enteric-coated phenylbutazone in general practice.


Opipramol and chlordiazepoxide in the treatment of anxiety in general practice.


Local treatment with a corticosteroid-antibiotic preparation in infections of the ear.


Writ in water. James Manby Gully, M.D. 1808-1883.


Jane Addams and the rescue fantasy.

Jane Addams and the rescue fantasy.


Diseases of Jews.

Diseases of Jews.


The biochemical basis for the drug actions of purines.


Robert Schumann's life.

Robert Schumann's life.


The parotid puzzle: a review of the literature on human salivation and its applications to psychophysiology.


The place of roentgen diagnosis in treatment planning for cancers of the nasopharynx, paranasal sinus, and laryngopharynx.


Roentgen examination of the oropharynx and oral cavity.


Osteosarcoma of the jaw bones.

Osteosarcoma of the jaw bones.


The dissemination of tumors of the head and neck via the cranial nerves.


Radiologic diagnosis of salivary gland tumors.


The radiologic aspects of medullary (solid) thyroid carcinoma.


Neutralization of Vipera palestinae hemorrhagin by antibody fragments.


Relation of donor age to success in penetrating keratoplasty.


A procedure for lower lid reconstruction.


Repair of cicatricial entropion of upper eyelids.


Liquid silicone impregnantion of the corneal stroma. Use in corneal transplantation.


Biosynthesis of N-acetylanthranilic acid by aromatic auxotrophs of Aerobacter aerogenes and Escherichia coli.


Susceptibility to proteolysis as a probe of the conformation of ferritin and apoferritin in solution.


Strategy and tactics in protein chemistry.


Effect of streptomycin on lipid composition with particular reference to cyclic depsipeptide biosynthesis in Serratia marcescens and other micro-organisms. The addition of low concentrations of streptomycin (5-10mug/ml of medium) to Serratia marcescens caused significant alterations in the lipid composition of this organism, but neither growth nor pigmentation was affected. The acetone-soluble cyclic depsipeptides, which comprise on average 15% of the total lipid, were decreased almost to zero and the total lipid phosphorus was more than doubled in the presence of streptomycin. Most of the phospholipid increase was due to an increase in phosphatidylethanolamine. Cyclic depsipeptides were not leached from the cell in the presence of streptomycin, indicating a definite inhibition of the biosynthetic pathway. The effect of streptomycin on the reported peptidolipids of Rhodopseudomonas spheroides, Halobacterium halobium, Nocardia asteroides and Pseudomonas tabaci was investigated. In the case of the only strictly comparable cellular cyclic depsipeptide (that of N. asteroides) the biosynthesis was strongly inhibited by streptomycin, but cell weight was maintained or even slightly increased. A possible mode and site of action of low concentrations of streptomycin on bacterial lipids is discussed.


General practice trial of flucloxacillin in common respiratory tract infections.


A comparative trial of fenfluramine and diethylpropion inbesity.


Synchronous cine-pressure-flow cystography: a method of routine urodynamic investigation.


Controlled trial of amitriptyline in general practice. A controlled double-blind trial of amitriptyline at two dosage levels (75 and 150 mg/day), amylobarbitone (150 mg/day), and an inert substance for a period of four weeks was conducted on four matched groups of women attending their general practitioners and suffering from a depressive illness. Improvement at 7 and 28 days was noted on several measures of depression and anxiety in all treatment groups. Of these treatments amitriptyline 150 mg/day was the most consistent in relieving depression and anxiety. Troublesome side effects were equally distributed among the four treatments.


Medazepam compared with amylobarbitone in treatment of anxiety. A double-blind crossover comparison of medazepam 10 mg three times a day against amylobarbitone 60 mg three times a day in outpatients with neurotic anxiety showed that medazepam was superior in relieving symptoms. At this dose of medazepam drowsiness or ataxia was rarely a problem.


Azathioprine in treatment of bullous pemphigoid. Azathioprine was given to 11 patients with pemphigoid who had been on long-term maintenance therapy with prednisone or prednisolone. In nine of these prednisone therapy was withdrawn and all were maintained symptom-free on azathioprine alone, while in two the dose of prednisone was considerably reduced. One patient who had never received corticosteroids was controlled by azathioprine alone during the initial acute phase of the illness. Since azathioprine acts slowly, it is recommended that corticosteroids should be used together with azathioprine during the acute stage. Thus azathioprine is valuable in long-term management of pemphigoid, particularly in patients showing corticosteroid toxicity or in whom the minimum maintenance dose is dangerously high.


Survey for trypanosome infections in domestic cattle and wild animals in areas of East Africa. 3. Salivarian trypanosome infections in cattle in relation to the Glossina distribution in Busoga District, Uganda.


Howard B. Burchell, M.D.

Howard B. Burchell, M.D.


The cyclamate story unfolds.

The cyclamate story unfolds.


Latst work on dieldrin.

Latst work on dieldrin.


Phenacetin as a carcinogen: an unsatisfactory picture.


Ben Jonson's tawney weed.

Ben Jonson's tawney weed.


More light on beryllium.

More light on beryllium.


More about isonicotinic acid hydrazide toxicity.


High-resolution electrocardiography.

High-resolution electrocardiography.


The effect of pH, temperature, and organic solvents on the kinetic parameters of Escherichia coli alkaline phosphatase.


Instrumentation in criminalistics.

Instrumentation in criminalistics.


The role of migrant population in studies of selected cancer sites: a review.


Psychologic and social precursors of coronary disease. (II).


Co-operation for hemodialysis programs.

Co-operation for hemodialysis programs.


Surgical construction of the vagina and labia in male transsexuals.


Ten years with the palatal island flap.

Ten years with the palatal island flap.


Immediate reconstruction with bipolar scalp flap after excisions of huge cheek cancers.


Carl Ferdinand von Graefe (1787-1840).

Carl Ferdinand von Graefe (1787-1840).


Reconstruction of a stenosed and crushed laryngeal airway.


Xeroderma pigmentosum--five-year arrest after total resurfacing of the face.


Frederick A. Figi 1892-1970.

Frederick A. Figi 1892-1970.


Physiological records from the ventrolateral thalamus during stereotactic operations on Parkinsonian patients. Report from a multidisciplinary team.


The type of lesion produced in stereotactic operations.


The production and distribution of milk in the 19th century.


Portable 90Sr-90Y applicator with interchangeable plastic shunt for extracorporeal blood irradiation.


Psychological examination before and after stereotactic operations in Parkinson patients.


Reaction to socio-documentary film research in a mental health clinic.


Long-term results of stereotactic operations for Parkinson's disease.


Pemphigus and other diseases.

Pemphigus and other diseases.


Folic acid deficiency complicating malaria.


Bullous pemphigoid in childhood. Immunofluorescent studies.


The immunologic properties of free endotoxin of Shigella sonnei.


Attempted culture of pathogenic Treponema pallidum in the presence of various bacteria and in their culture filtrates.


A study on labeling Reiter treponemes and Treponema pallidum with 14C.


Peptidase activity in Reiter treponemes.


Immunosuppression of the donor in order to affect chronic secondary disease of the recipient.


The nature of experimental second-set kidney transplant rejection. 1. The role of coagulation in hyperacute (second-set) renal allotransplant rejection in dogs.


Demonstration of a virus-like agent contaminating material containing the Stockholm substrain of the Nichols pathogenic Treponema pallidum.


Attempts at immunization against syphilis with avirulent Treponemma pallidum.


The screening of atherosclerotic patients: a new epidemiological approach.


Studies in non-gonococcal urethritis therapy. The long-term value of tetracycline.


Robert Allen Cleghorn, M.D., the well-tempered psychiatrist.


Twenty-five years of biochemical psychiatry.


High doses of spironolactone (Aldactone, SC-14266, Verospirone) alone and in combination with triamterene and-or diuretics in the treatment of refractory edema associated with secondary hyperaldosteronism.


The dream of Charles Dickens.

The dream of Charles Dickens.


Effect of colcemid on the locomotory behaviour of fibroblasts.


Structural alteration of intracellular phiX174 DNA following infection of host cells in which protein synthesis is inhibited.


Colicin E3-directed changes in ribosome function and polyribosome metabolism in Escherichia coli K12.


Replication of bacteriophage M13. IV. Synthesis of M13-specific DNA in the presence of chloramphenicol.


Model for the elongation of polynucleotide chains by polynucleotide phosphorylase.


Contribution of the bacterial recombination function to replication of bacteriophage P2.


Asymmetric segregation of the complementary sex-factor DNA strands during conjugation in Escherichia coli.


Some remarks on revascularisation of the leg arteries.


Regulation of early RNA synthesis in bacteriophage T4-infected Escherichia coli cells.


Clustered genes for ribosomal ribonucleic acids in Escherichia coli.


The lac repressor-operator interaction. 3. Kinetic studies.


On the process of cellular division in Escherichia coli. 3. Thermosensitive mutants of Escherichia coli altered in the process of DNA initiation.


Effect of incubation conditions on the nucleotide sequence of DNA products of unprimed DNA polymerase reactions.


Reconstitution of a functional membrane enzyme system in a monomolecular film. I. Formation of a mixed monolayer of lipopolysaccharide and phospholipid.


A preferred origin and direction of bacteriophage T4 DNA replication. I. A gradient of allele frequencies in crosses between normal and small T4 particles.


Reconstitution of a functional membrane enzyme system in a monomolecular film. II. Formation of a functional ternary film of lipopolysaccharide, phospholipid and transferase enzyme.


Sequential steps in the in vivo assembly of the RNA bacteriophage fr.


System theoretic analysis of models: computer simulation of a living cell.


An unusual lac repressor mutant.

An unusual lac repressor mutant.


The antibiotic sensitivity of 100 isolates of Escherichia coli, with special reference to the domiciliary treatment of urinary tract infections.


Matthew Joseph Slattery.

Matthew Joseph Slattery.


Guy Austin Lendon.

Guy Austin Lendon.


William Joseph Newing.

William Joseph Newing.


The acromegalic jaw: a novel source of bone.


A lodge agreement.

A lodge agreement.


Stereology: applications to biomedicalresearch.


The clinical trial: an exercise in logic.


The influence of the individual in clinical trials.


Some problems of measurement in clinical trials of physiotherapy, with particular reference to the assessment of pain.


Guidelines to research.

Guidelines to research.


After the planners.

After the planners.


Reconstruction of midline skin defects of the nose.


Lethal midline granuloma of the face. Case report.


Intra-osseous anchorage of dental prostheses. I. Experimental studies.


Streptomycin plus pyrazinamide in the retreatment of pulmonary tuberculosis--second report. A co-operative study in East African hospitals, clinics and laboratories with the collaboration of the East African and British Medical Research Councils.


The efficiency of methods of diagnosing pulmonary tuberculosis: an investigation in a chest clinic in Algiers.


BCG vaccination: a comparison of post-vaccination tuberculin sensitivity after oral and intradermal vaccination of newborn infants.


The fluorescent antibody test in human tuberculosis: a pilot study.


Study on the monthyl requirements of calories and the supply of essential nutrients in the rural population of different countries.


Water and life.

Water and life.


Nutritional and epidemiologic factors related to heart disease.


Cellulose and cellulolysis.

Cellulose and cellulolysis.


Olfactory and gustatory problems. An introduction to the technological, nutritional and physiological aspects of the organoleptic assessments of food characteristics.


The spherical implant.

The spherical implant.


Influence of cooking on foodstuffs.

Influence of cooking on foodstuffs.


Role of the ruminant in world food supply.


Composite reconstruction of the open mastoidectomy ear.


Food allergy. The chemical nature of the substances eliciting symptoms.


Nutrition and the nervous system in farm animals.


The Iowa enucleation implant.

The Iowa enucleation implant.


The control of ovarian function.

The control of ovarian function.


Red cell and platelet electrophoresis in coronary heart disease.


Platelets in thromboembolic disease.

Platelets in thromboembolic disease.


Platelet pharmacology in relation to thrombosis.


Platelet aggregation in diabetes mellitus.


Fibrinolytic activity in human coronary arteries review and quantitative studies.


Pathogenesis of coronary thrombosis, intramural and intraluminal hemorrhage.


Fibrinolysis and its pharmacological enhancement in occlusive vascular disease.


The search for an anti-thrombotic agent.


Current status of diastolic augmentation for circulatory support.


Vascular endothelial damage and thrombosis.


Osteochondritis dissecans of the knee-joint. Description of an operative technique.


Physical factors in arterial sclerosis and stenosis.


An explanation for variations in distribution of stroke and arteriosclerotic heart disease among populations and racial groups.


Isolation of Salmonella typhi-murium from municipal water, Riverside, California, 1965.


A waterborne epidemic of salmonellosis in Riverside, California, 1965. Epidemiologic aspects. A collaborative report.


Effect of vagotomy and-or antrectomy on gastric secretion stimulated by intravenous infusion of bethanechol chloride. Study on rats with gastric fistula.


Evaluation of methods and clinical applications of plasma progesterone assays.


The gamut of histoplasmosis.

The gamut of histoplasmosis.


Electron capture detection of steroids isolated from biological samples.


Alterations in immunologic mechanisms in diseases of the gastrointestinal tract.


Genetic determination of bacteriocin production by Enterobacter aerogenes.


Occurrence of normal agglutinins for various serologic types of staphylococci.


Marijuana and the Assassins, an etymological investigation.


Pepsin digestion of human G-myeloma proteins of different subclasses. I. The characteristic features of pepsin cleavage as a function of time.


Notes on the large scale preparation and on the properties of anti-lymphocyte serum for use in mice. Techniques.


Suppression of autoimmune disease in New Zealand mice associated with infection with malaria. I. (NZBxNZW) F1 hybrid mice.


The effect of pertussis vaccine on the immune response of mice to sheep red blood cells.


A simple method to obtain the mycococcus form of Mycobacterium phlei.


The relationship between controlled projection responses and sociometric status.


Tissue transplantation-the universal donor and blood group antibodies.


Factors concerned in the lysis of bacteria in the alimentary tract of sheep.


The N.M.A. from the terrace of 75 years. President's inaugural address.


The Diamond Jubilee of the National Medical Association.


The president-Elect of the National Medical Association, Dr. Emerson Coleman Walden.


Dr. Earl Belle Smith awarded Distingusihed Service Medal for 1970.


William Henry Harris, M.D., 1867-1934, with notes on the Georgia State Medical Association.


Progestagens in bitches: a review.

Progestagens in bitches: a review.


Further genetic characteristics of methionine mutants and their suppressors in Aspergillus nidulans.


General practitioners' forum. Flucloxacillin in the treatment of skin and soft-tissue infections.


Efficacy of cephalexin in common infections in general practice.


Beethoven: a medical view.

Beethoven: a medical view.


Adsorption of triazine herbicides on soil organic matter, including a short review on soil organic matter chemistry.


Movement of s-triazine herbicides in soils.


Microbial degradation of s-triazine herbicides.


Introduction to triazine-soil interactions.


Persistence of triazine herbicides in soils.


Nonbiological detoxication of the s-triazine herbicides.


Factors influencing the adsorption, desorption, and movement of pesticides in soi.


Ways and means to influence the activity and the persistence of triazine herbicides in soils.


Quantitative determination of triazine herbicides in soils by bioassay.


Mechanisms of adsorption of s-triazines by clay colloids and factors affecting plant availability.


Quantitative determination of triazine herbicides in soils by chemical analysis.


An old manuscript recipe book.

An old manuscript recipe book.


The influence of lyophilized bne and cartilage grafts on regeneration of alveolar bone in parodontopathy.


Treatment of chronic irreversible renal insufficiency by means of repeated peritoneal dialysis.


High frequency low tidal volume positive pressure ventilation.


Ultrastructure of calcifying tissues.

Ultrastructure of calcifying tissues.


Abraham Jacobi award address.

Abraham Jacobi award address.


Hypophosphatemia with muscle weakness due to antacids and hemodialysis.


Forerunners of The American Journal of Occupational Therapy.


The American Journal of Occupational Therapy. Official publication of The American Occupational Therapy Association.


Molecular weight of Escherichia coli beta-galactosidase in concentrated solutions of guanidine hydrochloride. The molecular weight of Escherichia coli beta-galactosidase was determined in 6m- and 8m-guanidine hydrochloride by meniscus-depletion sedimentation equilibrium, sedimentation velocity and viscosity. Sedimentation equilibrium revealed heterogeneity with the smallest component having a molecular weight of about 50000. At lower speeds, the apparent weight-average molecular weight is about 80000. By use of a calculation based on an empirical correlation for proteins that are random coils in 6m-guanidine hydrochloride, sedimentation velocity gave a molecular weight of 91000, and the intrinsic viscosity indicated a viscosity-average molecular weight of 84000. Heating in 6m-guanidine hydrochloride lowered the viscosity of beta-galactosidase in a variable manner.


The control of ribonucleic acid synthesis in bacteria. Steady-state content of messenger ribonucleic acid in Escherichia coli M.R.E. 600. 1. The technique of DNA-RNA hybridization was used to follow changes in the amount and average lifetime of unstable messenger RNA in Escherichia coli M.R.E. 600 over a wide range of different growth conditions. The method of analysis was based on the kinetics of incorporation of exogenous labelled nucleic acid bases into the RNA of steadily growing cultures, as described by Bolton & McCarthy (1962). 2. The ratio of the average lifetime of messenger RNA to the mean generation time of E. coli cultures was constant over the temperature range 25-45 degrees C in a given medium, but the constant varied with the nature of the growth medium. For cultures growing in sodium lactate-salts or glucose-salts media the ratio was 0.046+/-0.005 and in enriched broth it was 0.087+/-0.009. Measurements of the amounts of transfer RNA, ribosomal RNA and messenger RNA were also made. The results confirmed earlier reports that the ratio of the amount of messenger RNA to the amount of ribosomes in the cells is virtually constant. On the other hand, the ratio of the amount of transfer RNA to the amount of ribosomal RNA decreased with increasing growth rate at a given temperature. 3. In cultures at temperatures higher than necessary for optimum rates of growth the average lifetime of messenger RNA lengthened in harmony with the increased time required for cell division. It seems that suboptimum growth rates at higher temperatures cannot be explained simply as a combination of increased rates of synthesis and breakdown of messenger RNA with a grossly decreased efficiency of translation. The absolute rate of messenger RNA synthesis was lowered, and its amount in the cells was typical of all other cultures grown at lower temperatures in the same medium. 4. The rate of entry of exogenous labelled uracil into unstable messenger RNA and stable ribosomal RNA was constant in all media at all temperatures in the approximate ratio 1:2. In media supporting a lower rate of growth, e.g. lactate-salts or glucose-salts media, the messenger RNA fraction constituted 2.2+/-0.3% of the total cellular RNA. In enriched broth 3.6+/-0.3% of the total RNA was messenger.


Menstrual difficulties in colonial Mexico.


Some observations of France in the late eighteenth century (Arthus Young).


Effects of atmospheric electricity (Thomas M. Madden).


Columbia alumni serving as naval surgeons in the War of 1812.


The personalities of two pioneer medical women: Elizabeth Blackwell and Elizabeth Garrett Anderson.


Simple adaptations to relaxation chairs.


Tumor hemorrhagic properties of surface components of Salmonella typhimurium mutants.


Molecular vital statistics: the significance of shape. A review article.


Amniotic fluid.

Amniotic fluid.


Some current concepts of urinary tract infections.


Different species of 70S ribosomes of Escherichia coli and their dissociation into subunits.


Antigenic changes in Shigella flexneri following conjugation with Escherichia coli HfrC.


Wild-type Gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice. The pathogenesis of the spontaneous glomerulonephritis of NZB and (NZB x NZW) F(1) hybrid mice is related at least in part to the formation of natural antibody against antigens of the G (Gross) system, and apparently to the deposition in the glomeruli of immune complexes of G natural antibody with G soluble antigen (GSA), type-specific antigen specified by wild-type Gross leukemia virus. G natural antibody and GSA are detectable in the acid-buffer eluate of the kidneys of NZB mice during the course of the glomerulonephritis. (NZB x NZW) F(1) hybrid mice develop glomerulonephritis and produce GSA and free G natural antibody earlier in life than do NZB mice. The proteinuria manifestation of the gomerulonephritis of (NZB x NZW) F(1) hybrid mice becomes increasingly prevalent as GSA undergoes immune elimination from the circulation. Gross leukemia virus-specified antigens together with bound immunoglobulins are located in the glomerular lesions of (NZB x NZW) F(1) hybrid mice, both in the mesangium as observed in NZB mice and also in the wall of the peripheral capillary loops of the glomeruli.


Immunosuppressive and graft-rejecting anti--bodies in heterologous anti-lymphocytic serum. Skin allografts survived longer on ALS-treated, complement-deficient (C5 negative) recipients than on ALS-treated, complement-competent (C5 positive) recipients. Administration of C5-positive serum to C5-negative, ALS-treated recipients resulted in reduced graft survival. A percentage of grafts from ALS-treated, C5-positive donors was rejected when transferred to untreated syngeneic recipients; this was not observed when C5-negative, syngeneic animals served as ALS-treated donors and untreated recipients. It was concluded that ALS has graft-rejecting properties which are promoted by late acting complement components. Unlike ALS-mediated graft rejection, ALS-mediated immunosuppression appeared to be independent of the late acting complement components. The effect of ALS on the humoral response to sheep erythrocytes was examined in complement-deficient and complement-competent mice. Immune-suppression was determined by ALS treatment of C5-competent and C5-deficient mice and also by transfer of in vitro ALS-treated spleen cells from C5-negative and C5-positive donors to cyclophosphamide-treated recipients. The ability of ALS to depress the humoral response to sheep cells and to decrease immunological competence of spleen cells was the same in the presence as in the absence of C5.


Ergot poisoning.

Ergot poisoning.


Studies on mitochondrial tRNA from animal cells. II. Hybridization of aminoacyl-tRNA from rat liver mitochondria with heavy and light complementary strands of mitochondrial DNA.


Frameshift mutation in the lysozyme gene of bacteriophage T4: demonstration of the insertion offour bases and the preferential occurrence of base addition in acridine mutagenesis.


Inactivation and degradation of messenger ribnucleic acid from the lactose operon of Escherichia coli.


Inactivation and reactivation of ribosomal subunits: the peptidyl transferase activity of the 50 s subunit of Escherihia coli.


Crystallization and preliminary crystallographic data for thioredoxin from Escherichia coli B.


The Kornberg polymerase and the repair of irradiated T4 bacteriophage.


Limited exposure in cerebral surgery. Technical note.


Total removal of large global meningiomas at the medial aspect of the sphenoid ridge. Technical note.


Neurogenic bladder in parkinsonism: effect of thalamotomy.


Veno-arterial shunting in experimental pulmonary embolism.


Further studies in Bart's hydrops foetalis in Singapore.


Techniques for general anesthesia in miniature pigs.


Endotoxin effect on respiration of rat liver mitochondria.


Plants used against cancer. A survey.

Plants used against cancer. A survey.


The treatmnt of osteoporosis.

The treatmnt of osteoporosis.


Preservation of cadaver kidneys before transplantation.


A study on the interpretation of freeze-etched animal tissues and cell organelles.


Effects of a counterirritant on muscular distress in patients with arthritis.


Oral aspects of aging.

Oral aspects of aging.


A method of analysis of radiation response based on enzyme kinetics.


On the time scale for radioprotection by and permeation of glycerol in anoxic cells of E. coli B.


Stanford School of Medicine. I. Problems over more than money. Since World War II the American medical school has become a highly complex institution and, like other American institutions today, the medical school is being challenged to respond to diverse and often conflicting demands. In part the pressure comes from activists who insist that the medical school more fully meet the needs of the community by reforming both training and the delivery of medical care. But another sort of pressure is exerted as a result of changes in internal relationships that have occurred in the last two decades in large measure because of the federal support of biomedical research. As in most institutional conflicts the dispute is expressed in contests over power and money, but, at a more fundamental level, what is involved is the value and reward system of academic medicine and the question of how the medical school is to be governed. This is the first of three articles which will attempt to discuss these issues in the context of the development of one medical school-Stanford's. The first article will describe the pattern and policies of expansion since World War II, and the other two will examine the effects of internal and external pressures for change.


Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin. A cytoplasmic enzyme from guinea pig brain was shown to transfer methyl groups from S-adenosylmethionine to only one of 19 arginine residues in the basic protein from human brain. The products were omega-N-monomethylarginine and omega-N,N'-dimethylarginine. These methylated arginines are adjacent to the main encephalitogenic determinant in the protein. Methylation may aid in the transfer of this region of the protein into the nonpolar environment within myelin and in maintaining the integrity of myelin.


Equal rights for women: voices from the past.


Synthesis of ribonucleic acid in purine-deficient Escherichia coli and a comparison with the effects of amino acid starvation. 1. Experiments with rifampicin and stringent strains of Escherichia coli (pro(-)purB(-)rel(+)) indicate that purine deficiency does not decrease and may considerably increase the potential for RNA synthesis by RNA polymerase molecules that are bound to DNA and have already commenced transcription. 2. DNA-RNA hybridization experiments indicate that purine starvation increases the distribution of bound RNA polymerase molecules between the cistrons for mRNA and those for stable RNA. 3. Synthesis of beta-galactosidase mRNA is more dependent on the ability to synthesize guanine nucleotides than on the ability to synthesize adenine nucleotides. 4. Amino acid starvation tends to decrease the potential for RNA synthesis by RNA polymerase molecules bound to DNA. 5. Since this effect differs from that due to purine starvation, amino acid control of RNA synthesis does not appear to operate solely by causing a deficiency of purine nucleotides. 6. The results are discussed in terms of the ability to initiate RNA chains and to extend them under different circumstances.


Barbiturate abuse and addiction and their relationship to alcohol and alcoholism.


Limitations of computers in medicine.

Limitations of computers in medicine.


Professor G.H. Cooray, O.B.E, M.D., F.C. Path., F.R.C.P.


Host range & plaque size characters of wild type colidysentery phages of Escherichia coli strain B.


The nature of diabetes mellitus. A point of view.


Changes in blood and plasma volumes during growth.


Significance of borderline counts in screening programs for bacteriuria.


Late-onset hypogammaglobulinemia with cellular immune deficiency.


The electrocardiogram in the newborn period. II. The infant with disease.


More on renal transplantation.

More on renal transplantation.


The pulmonary surfactant content of the inclusion bodies found within type II alveolar cells.


Washington's blood letting.

Washington's blood letting.


Streptococcal skin infection and acute glomerulonephritis.


Anaemia and skin disease.

Anaemia and skin disease.


The clinical significance of cutaneous xanthomas.


Cutaneous manifestations of visceral malignancy.


Altered repression behaviour in a feedback insensitive mutant of Escherichia coli K12.


A message of congratulations to Tadao Takatsu. On the occasion of age-imposed retirement.


AMA policy and Medicaid.

AMA policy and Medicaid.


A selected public health bibliography with annotations.


Evaluating changes in symptoms during acute alcohol withdrawal.


Motor disorders induced by neuroleptics: a proposed new classification.


Chemical mutagens as a possible genetic hazard in human populations.


An outline of dental history.

An outline of dental history.


Beta-hydroxylation of tyramine by cockroach hemolymph.


Replacement of normal reflex behavior with misdirected reflexes in skin-grafted Ronidae.


Effect of pertussis antigen and cyclophosphamide on myeloma tumor.


Combined dihydralazine and propranolol in the treatment of hypertension.


Extrarenal effects of diuretic agents.

Extrarenal effects of diuretic agents.


Scientific contributions of Wendell H. Griffith to our understanding of the function of choline.


Beta receptor antagonism in hypertension; comparison with the effect of adrenergic neurone inhibition on cardiovascular responses.


Effect of age on the response to propranolol.


International Symposium on Clinical Pharmacology. Closing address.


Riot control agents. Introduction.

Riot control agents. Introduction.


Current trends in clinical pharmacology in the USA.


Chemical injuries of the cornea.

Chemical injuries of the cornea.


Clinical pharmacology in paediatrics.

Clinical pharmacology in paediatrics.


Practical pharmacokinetics as part of clinical pharmacology.


International Symposium on Clinical Pharmacology. Introduction.


The present status of clinical pharmacology in Yugoslavia.


Metabolic relationships in the transfer of methyl groups.


Biochemical interactions and metabolic fate of riot control agents.


The role of biometrics in clinical pharmacology.


Regulation of the tRNA methylases.

Regulation of the tRNA methylases.


Representative individual case and double blind tests.


The significance of properly designed pre-clinical studies in the clinical evaluation of new drugs.


Hyman Louis Naterman (1906-1969).

Hyman Louis Naterman (1906-1969).


The significance of plasma renin determinations for differential diagnosis of hypertensiony.


Contact dermatitis to chloroacetophenone.


Experimental study of the immunogenic and allergenic activity of different batches of Czechoslovak and Danish BCG vaccine in guinea pigs.


The significance of the total-body hematocrit in measurements of blood compartments.


Ureteral kinking and hydronephrosis in a transplanted kidney mimicking the rejection phenomenon.


Psychiatric changes in patients treated with levodopa. I. The clinical experiment.


Mechanisms of action of steroid hormones.


Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders.


Double-blind, placebo-controlled study of levodopa therapy in Parkinson's disease.


Heart transplantation.

Heart transplantation.


A trial of chemoprophylaxis of natural influenza infection with U.K. 2371.


Doctors prominent in museum development.


Orthotopic transplantation of the pig heart.


Current concepts of colitis. 1.

Current concepts of colitis. 1.


Current concepts of colitis. 2. Crohn's disease.


The development of renal surgery.

The development of renal surgery.


A historical review of chest diseases.

A historical review of chest diseases.


Some aspects of fish inspection and public health.


Tubular and interstitial nephritis produced by homologous heart homogenate in rabbits. 2. Anti-heart antibodies.


Immuno-fluorescent studies of renal biopsies in acute polyradiculitis.


Gout.

Gout.


Johannes Heinrich Schultz, M.D., 1884-1970.


A review of recent developments in veterinary sciences in the Federal Republic of Germany.


Nitrogen-retaining steroids and their application in disease.


Minority--group status and fertility: an extension of Goldscheider and Uhlenberg.


A new instrument for rapid measurement of blood oxygen saturation and Hb concentration.


An industrial view of current practice in predicting drug toxicity.


Versatility of the Haloxair apparatus.

Versatility of the Haloxair apparatus.


The role of immunology in human cancer research.


Acoustic phenomena in pericardial disease.


Sequential effect of angiographic contrast agent on canine renal and systemic hemodynamics.


Method, design, and analysis of a comparative study of analgetics.


Bone marrow and lymph node cells in the rejection of skin allografts in mice.


Comparative blood level study of different brands of chlordiazepoxide hydrochloride and their coadministration with chymotrypsin.


A comparative evaluation of intramuscular atropine, dicyclomine and glycopyrrolate using healthy medical students as volunteer subjects.


A case study of the Charles Manson group marriage commune.


Clinical implications of maternal employment: a review of research.


Alfred Adler and the fulfillment model of personality theorizing.


The utility of behavior management techniques in changing interracial behaviors.


Clinical trial of glybenclamide, a hypoglycaemic agent.


Burton's Anatomy of Melancholy.

Burton's Anatomy of Melancholy.


Two Philadelphia psychiatrists and a theory of American psychiatry.


The problem of the hit or myth approach to community mental health planning: reflections on George Albee's paper.


Hypoparathyroidism.

Hypoparathyroidism.


Academy critic shoots wildly but hits sore spot.


B-o-o-a-a-r-r-r-d-d. Dr. Bill Bowman finds relaxation in model trains.


Cytoplasmic inheritance in metazoa and its relationship to cell phenotype. I. Hypothesis.


Who originated the Z-plasty? (Charles Pierre Denonvilliers).


A new protein synthesis factor from Escherichia coli. A new factor that effects protein synthesis by Escherichia coli extracts was partially purified from the 1 M NH(4)Cl wash of E. coli ribosomes. This factor stimulates the binding of aminoacyl-tRNA to 30S ribosomes, and it increases the rate of synthesis of polyphenylalanine in the presence of 30S and 50S subunits.


Adler's theory of birth order.

Adler's theory of birth order.


Cataract extraction: section, sutures and lens delivery.


Australian College of Ophthalmologists: Officers of the Society and list of members.


Australian College of Ophthalmologists. Presidential address: an inevitable development.


Hereditary granular corneal dystrophy and associated aminoaciduria.


James Aloysius Flynn.

James Aloysius Flynn.


"Hidden" cellular electrolyte responses to hemorrhagic shock and their significance.


Prophylactic treatment in the management of predisposing retinal lesions.


Memoir of Earl Danford Bond (1878-1968).


Memoir of Thomas Klein. 1891-1970.

Memoir of Thomas Klein. 1891-1970.


Memoir of Benjamin D. Parish, Sr. 1877-1968.


Dr. A. M.-M. Payne.

Dr. A. M.-M. Payne.


The action of nitrofurantoin: inhibition of growth of Escherichia coli K 12 and of IPTG-induced beta-galaotosidase synthesis.


Anaesthetic and metabolic problems of liver transplantation.


Mechanical or spontaneous ventilation in the sitting position for neurosurgery?


The evaluation of mucolytic drugs in chronic bronchitis.


N-(5'-phosphoribosyl)anthranilate isomerase-indol-3-ylglycerol phosphate synthetase of tryptophan biosynthesis. Relationship between the two activities of the enzyme from Escherichia coli. Further evidence is presented to confirm the previous conclusion that the enzyme from Escherichia coli catalysing the two sequential reactions in tryptophan biosynthesis, N-(5'-phosphoribosyl)anthranilic acid (PRA) --> 1-(o-carboxyphenyl-amino)-1-deoxyribulose 5-phosphate (CdRP) --> indol-3-ylglycerol phosphate (InGP)+CO(2)+H(2)O, consists of a single polypeptide chain. The kinetic properties of the enzyme demonstrate that intermediate CdRP formed from PRA must dissociate from the enzyme before it can be converted into InGP. It is concluded that there are two distinct and non-overlapping catalytic sites on the enzyme for the two reactions. The expected complementation between a mutationally altered form of the enzyme lacking the first reaction and a mutationally altered form lacking the second reaction has been demonstrated in vitro by InGP formation from PRA. This system thus exhibits intracistronic complementation with a non-oligomeric protein gene product.


Inflammation and haemostasis in paraproteinaemias.


The significance of gastric antibodies.

The significance of gastric antibodies.


Allopurinol in psoriasis.

Allopurinol in psoriasis.


Replacement of the mitral valve with a mitral or aortic valve homograft.


Evidence for a refractory period in the neuroendocrine mechanism for the release of prolactin.


Relative efficacy of pinealectomy, hypothalamic and amygdaloid lesions in advancing puberty.


Inhibition of ovarian compensatory hypertrophy in the rat by intrahypothalamic implantation of methallibure.


Views of practicing physicians on the Mississippi medicaid program.


Behaviour of different endogenous pyrogens in a Biogel column.


Abortion: yes or no?

Abortion: yes or no?


Bubonic plague in the Southwestern United States. A review of recent experience.


The effect of counting geometry on the significance of myocardial blood flow measurements by the injection method.


Sensry deprivation as a field of study.

Sensry deprivation as a field of study.


The management of corneal lacerations.

The management of corneal lacerations.


The use of adhesives in anterior segment surgery.


Oral contraceptives and eye changes.

Oral contraceptives and eye changes.


Unilateral papilledema and the swinging flashlight test.


Unusual tumors in and around the eye.

Unusual tumors in and around the eye.


Management of orbital rhabdomyosarcoma.

Management of orbital rhabdomyosarcoma.


Ocular toxoplasmosis.

Ocular toxoplasmosis.


Simultaneous contrast in after images.

Simultaneous contrast in after images.


Modern indications for sinus surgery.

Modern indications for sinus surgery.


Voice therapy for hyperfunctional voice problems.


Reinnervation of the facial muscles following extratemporal facial nerve resection.


The evaluation of hearing impairment in the young deaf child.


The evaluation of the neuro-otologic patient.


The use of intravitreal air for the therapy of giant retinal tears.


Postoperative management of retinal detachment patients.


Photocoagulation coreplasty.

Photocoagulation coreplasty.


Vision substitution by tactile image projection.


Recent advances in bilirubin formation, transport, metabolism and excretion.


The characteristics of mixed micellar solutions with particular reference to bile.


Biochemical mechanisms of liver injury.

Biochemical mechanisms of liver injury.


The role of theliver in drug metabolism.


Some aspects of the interaction between natural and synthetic female sex hormones and the liver.


Measurement of portal pressure and its clinical application.


Hepatic fibrosis. Correlation of biochemical and morphologic investigations.


Convection, air mixing, and ultraviolet air disinfection in rooms.


Room air disinfection by ultraviolet irradiation of upper air. Air mixing and germicidal effectiveness.


Dr. LeClair--the man and the challenge.

Dr. LeClair--the man and the challenge.


The pathogenesis of hyperuricemia and gout in sickle cell anemia.


Studies of isolated synovial living cells of rheumatoid and nonrheumatoid synovial membranes.


Arteriovenous anastomosis.

Arteriovenous anastomosis.


Behavior in culture of three types of chondrocytes, and their response to ascorbic acid.


Terminal lens cell differentiation. 3. Initiator activity of DNA during nuclear degeneration.


In vitro radioprotection of mouse tail bones by dimethyl sulphoxide, glycerol and anoxia.


On the nature of reparable and non-reparable lethal damage in E. coli and bacteriophage induced by the photodynamic action of acridine orange.


Report on the University of Michigan Twenty-Third Conference on Aging.


Tophectomy and bone-grafting for extensive tophi of the feet.


Another way to manage the split-thickness skin donor site.


Osteomyelitis in the patient with sickle-cell disease.


The relationship between different transmissible plasmids introduced by F into the same strain of Escherichia coli K12.


Transfer factors in Escherichia coli with particular regard to their incidence in enteropathogenic strains.


Genetic mapping of a locus for triosephosphate isomerase on the genome of Escherichia coli K12.


Biochemical and genetical studies on ribose catabolism in Escherichia coli K12.


Mutants of Escherichia coli with altered surface properties which are refractory to colicin E2, sensitive to ultraviolet light and which can also show recombination deficiency, abortive growth of bacteriophage lambda and filament formation.


Medical education in Evansville--yesterday today and tomorrow.


Co-transduction with serB of a pleiotropic mutation affecting colicin E2 refractivity, ultraviolet sensitivity, recombination proficiency and surface properties of Escherichia coli K12.


Synthesis of messenger ribonucleic acid after bacteriophage T1 infection. Synthesis of host-specific and phage-specific messenger ribonucleic acid (mRNA) was studied in bacteria infected by unmodified (T1 . B) or modified [T1 . B(P1)] bacteriophage T1. In a "standard" infection of Escherichia coli B by T1 . B (no host-controlled modification involved), the rate and amount of T1 mRNA synthesis was intermediate between those values reported for infections by a virulent phage such as T4 or a temperate phage such as lambda. The initial rate of mRNA synthesis was slightly increased after T1 . B(P1) infection of E. coli B in comparison with T1 . B infection of the same host. Little or no phage mRNA synthesis could be detected in T1 . B infection of E. coli B(P1). Phage mRNA synthesis in T1 . B(P1)-infected E. coli B(P1) cells was approximately the same in amount as that seen in T1 . B(P1) infection of E. coli B. Synthesis of host-specific mRNA continued throughout the latent period in all infections studied. However, the enzyme beta-galactosidase could not be induced, except after T1 . B infection of E. coli B(P1). In an attempt to understand the apparent differences in mRNA synthesis after infection of E. coli B by phages T1 . B or T1 . B(P1), the effect of altered T1 deoxyribonucleic acid (DNA) methylation on mRNA synthesis was studied. Methyl-deficient T1 DNA, made in cells infected with ultraviolet-irradiated phage T3, inhibited (14)C-uridine incorporation more strongly than normal T1. One passage of methyl-deficient T1 through E. coli B restored uracil incorporation rates to those seen with ordinary T1. This suggests that methylation of T1 DNA can influence the rate of phage mRNA synthesis. However, attempts to relate the difference in mRNA synthesis seen between T1 . B and T1 . B(P1) in E. coli B to the activity of the P1 modification gene were not conclusive.


T3 and T7 bacteriophage deoxyribonucleic acid-directed enzyme synthesis in vitro. The T3 phage enzymes S-adenosyl methionine cleaving enzyme and lysozyme and the T7 lysozyme were synthesized in a deoxyribonucleic acid (DNA)-dependent, cell-free system derived from uninfected Escherichia coli. The data presented suggest that these enzymes are encoded in that portion of the DNA which is transcribed early after infection.


Bacteriophage tail components. 3. Use of synthetic pteroyl hexaglutamate for T4D tail plate assembly. The assembly of T4D tail plates occurring during in vitro complementation reactions was found to be stimulated by pteroyl hexaglutamate. Neither the pteroyl pentaglutamate nor the pteroyl heptaglutamate substituted for the hexaglutamate. A small stimulation of the rate and amount of T4D tail plate assembly was observed in untreated extracts. A greater stimulation occurred when activated charcoal-treated bacterial extracts were used. Charcoal treatment inhibited complementation only when no preformed tail plates were present in the extracts, and the inhibition was reversed by the addition of 9 x 10(-6)m chemically synthesized pteroyl hexaglutamate. The stimulation is apparently due to a requirement for the pteroyl hexaglutamate for tail plate assembly.


Stabilization of 70S ribosomes by spermidine.


Localization of two recognition sites in yeast valine tRNA I.


Inhibition of host protein synthesis during infection of Escherichi coli by bacteriophage T4. 3. Inhibition by ghosts. Deoxyribonucleic acid (DNA)-less T2 "ghosts" were prepared by osmotic shock and purified by KBr density gradient centrifugation. Escherichia coli B was treated with these ghosts in inorganic salts-glycerol medium to see which features of phage infection could be elicited by ghosts. At a multiplicity that was just sufficient to block induction of beta-galactosidase (EC 3.2.1.23), 89% of the bacteria were killed and the rates of ribonucleic acid (RNA) and DNA synthesis were about 10 to 15% of normal. However, protein synthesis was almost completely blocked but resumed after 30 min. During this period, it was possible to induce messenger RNA (mRNA) from the lactose operon, although this mRNA could not be translated into active beta-galactosidase. These results suggest to us that the viable cells surviving ghost infection synthesize nucleic acids at close to a normal rate but are temporarily blocked in protein synthesis. The continued formation of untranslated host mRNA mimics the pattern of bacterial synthesis just after whole-phage infection, and is consistent with the interpretation that the immediate block in the initiation of host translation by these viruses is due to their attachment.


Capsid size and deoxyribonucleic acid length: the petite variant of bacteriophage T4. A mutant which produces a small-headed ("petite") variant of bacteriophage T4 is described. The mutation (E920g) maps in a new gene (66) between genes 23 and 24. Petite phage particles composed up to 70% of the phage yield. The petite phage was nonviable upon single infection but produced progeny when two or more infected a cell. Its genome was shortened by a random deletion of about 30%, and deoxyribonucleic acid (DNA) extracted from the particles was 0.68 the length of normal T4 DNA. The reduction in DNA length was accompanied by a proportional reduction in head volume. Double mutants between E920g and head-defective mutants in gene 21 produced unusually high frequencies of spherical capsidlike structures (tau-particles).


Synthesis by ribosomes of viral coat protein containing ester linkages.


Infantile cortical hyperostosis and skull defects.


A Cambridge eccentric. Robert Glynn, M.D., 1719-1800.


Antidepressant effects of tranquillizers.


Anti-diarrhoeal agents.

Anti-diarrhoeal agents.


Sensitivity to inflation of the respiratory system in the chicken.


Plasmodium falciparum in ascitic fluid.

Plasmodium falciparum in ascitic fluid.


A double-blind study to determine the maximum tolerated dose of ethionamide, when administered twice-weekly to patients with pulmonary tuberculosis.


Prophylactic and sporontocidal treatment of chloroquine resistant Plasmodium falciparum from Malaya.


Screening for atypical mycobacteria.

Screening for atypical mycobacteria.


Electron microscopy of surface of two strains of Streptomyces aureofaciens during tetracycline biosynthesis.


Antagonistic relations in some marine psychrotrophic bacteria and enterobacteria.


The biosynthesis of corrinoids by Propionibacterium shermanii 1 in the cheese-whey medium.


Ileo-cutaneous ureterostomy in children. 1. Indications and results.


The indirect estimation of arterial carbon dioxide using the rebreathing method during anaesthesia with controlled respiration.


Denaturation of DNA after x-irradiation in vitro.


Presumed anticodon structure of glutamic acid tRNA from E. coli: a possible location of a 2-thiouridine derivative in the first position of the anticodon.


Activation of phosphoenolpyruvate carboxylase of Escherichia coli by free fatty acids or their coenzyme A derivatives.


Evidence for the early synthesis of T4 bacterio- phage-coded transfer RNA.


Identification of filamentous micro-organisms of the human dental plaque by immuno-fluorescence.


Histological appearance and chemical composition of enamel proteins from mature human molars.


Acquired organic integuments of human enamel: a comparison of analytical studies with optical, phase-contrast and electron microscope examinations.


Hemagglutinin, hemolysin, and bactericidin response of dogs with bladder pouch infection.


The effect of autogenous urine on leukocytic defenses in man. II. The response to varied concentrations of saline, urea, and urine.


Effects of oral contraceptives on urinary bacterial growth rate.


James C. Kimbrough (1887-1956).

James C. Kimbrough (1887-1956).


Antibody synthesis in lymphoid organs of two ma- rine teleosts.


Polyribosome formation in relation to accumulation of plasma cells.


5 days with a heart transplant team.

5 days with a heart transplant team.


Azathioprine and prednisone in the treatment of adults with lupus nephritis. Clinical, histological, and immunological changes with therapy.


Mutations in the galactose-operator.

Mutations in the galactose-operator.


A review of cyanide concentrations found in human organs. A survey of literature concerning cyanide metabolism, 'normal', non-fatal, and fatal body cyanide levels.


Gal transduction by phage lambda: on the origin and nature of LFT transducing genomes.


A bacterial mutation which affects recognition of the N gene product of bacteriophage lambda.


Dominance study with rifampicin-resistant mutants of E. coli K 12.


DNA synthesis in F- cells treated with filtrates of male strains of E. coli K 12.


Genetic locations of uvrD and pol genes of E. coli.


The history of meat hygiene and inspection in New Zealand up to the formation of the Meat Division in 1963.


Edinburgh's obstetrical heritage: some names from the past.


The past and present of the General Medical Council.


Deep vein thrombosis.

Deep vein thrombosis.


Weber and Freud: on the nature and sources of authority.


Indices of inflammatory activity. Relationship between isotope studies and clinical methods.


When a defective infant is born.

When a defective infant is born.


On Medicaid.

On Medicaid.


Human territoriality and its cathexis.

Human territoriality and its cathexis.


Esophageal hiatus hernia.

Esophageal hiatus hernia.


Beta cell secretion--from the standpoint of a pathobiologist.


Analysis of psychotic language--a review.


Action of RNA polymerase from Escherichia coli. Homopolymerization with ATP and -or UTP as substrates in the absence of template.


The AFDE Scholarship Program for Negro students.


Current publications in gerontology and geriatrics.


Methotrexate therapy for P vivax malaria.


Fear of enlightenment.

Fear of enlightenment.


Professor G. Hübscher.

Professor G. Hübscher.


How Henoch treated children with encopresis.


The relation of explaining and understanding in psychoanalysis: demonstrated by one aspect of Freud's approach to literature.


List of nursing schools and colleges in the Philippines.


The Philippines' Medicare--a challenge to our hospitals.


Management of burns in the multiple inury patient.


Topical therapy.

Topical therapy.


The surgical treatment of mitral insufficiency associated with torn chordae tendineae.


[Outline of treatment of tooth defects and tooth replacement].


Applications of germ-free animals to problems in comparative medicine.


Lupinosis.

Lupinosis.


Studies of alpha-methyl-para-tyrosine, L-dopa, and L-tryptophan in depression and mania.


Lithium in pregnancy: a review with recommendations.


1970 anniversaries.

1970 anniversaries.


On the language of pain.

On the language of pain.


Samuel Nickles, dry and quaint: a landmark of Western medicine. The life of Dr. Samuel Nickles 1833-1908, medical practitioner and teacher in Cincinnati, Ohio, is written almost entirely from information found in a collection of letters, personal papers, clippings from newspapers and journals, and other personal possessions donated to the author by Martha Nickles, Samuel's 89-year-old daughter.


Mechanization of library procedures in the medium-sized medical library. X. Uniqueness of compression codes for bibliographic retrieval. Two-word compression techniques, the University of Chicago experimental search code and a phonetic code similar to the SOUNDEX coding system, were tested as search codes on a data base of 7,464 bibliographic records. These codes were automatically generated and tested for uniqueness. A modified version of the University of Chicago search code produced the best results with a uniqueness factor of 98.83 percent. The algorithms for generating these codes are explained, and implication of the findings for medium-sized libraries are discussed.


The surgeon and cancer research. Bruce Memorial Lecture.


Bone and skeletal blood flow in man measured by a radioisotopic method.


The Bruce Lecture.

The Bruce Lecture.


The first twenty years of the association of bone and joint surgeons.


Skeletal complications of kidney disease.


Organ culture method using a modified Grobstein raft technic.


Effects of vitamin C and sulfite on embryonic mouse radii grown in organ culture.


Isolation of viable neurons from embryonic spinal ganglia by centrifugation through albumin gradients.


Heterologous DNA nuclear uptake by mouse DNA fibroblasts in vitro and its early fate.


Beacon light for fifty years.

Beacon light for fifty years.


Editorial. Anniversary appreciation.

Editorial. Anniversary appreciation.


President Otto W. Brandhorst.

President Otto W. Brandhorst.


Electron microscopic observation of cerebro-spinal fluid cells--a new method for embedding of CSF cells.


The role of occlusion in preservation and prevention in complete denture prosthodontics.


Alveolar bone resorption under complete dentures.


Fulcrum and retention lines in planning removable partial dentures.


Maintaining supporting structures with a removable partial prosthesis.


Cast shell veneer crowns.

Cast shell veneer crowns.


Te histological response of the dental pulp to cresatin.


An evaluation of five inlay investing techniques employed with different types of wax patterns.


Health services research in dentistry.

Health services research in dentistry.


The "Fruit-Tree Experiment" as a measure of retarded children's preferences of fruit trees under varied conditions of color availability.


Anxiety indicators in the Draw-A-Person Test for clinic and nonclinic boys and their parents.


The potato--worth its weight in gold.

The potato--worth its weight in gold.


Santa Claus drawings by Negro and white children.


Editorial. No excuses appearappropriate.


Treatment of fractured and avulsed teeth.


Abdominal surgery. I.

Abdominal surgery. I.


Salmonella infection: diagnosis and control.


Sponges, cancer chemotherapy, and cellular aging.


Worldwide somatic comparisons among contemporary human groups of adult females.


Boerhaave's syndrome: a review of six cases of spontaneous rupture of the esophagus secondary to vomiting.


Lack of acceleration of healing with zinc sulfate.


Halsted at Bellevue: 1883-1887.

Halsted at Bellevue: 1883-1887.


Late suture failure in the pathogenesis of anastomotic false aneurysms.


Duodenal atresia and stenosis in infants.


Stimulation of glucose utilization by thioctic acid in rat diaphragm incubated in vitro.


2-thiouridine 5'-phosphate and its inhibition of aspartate transcarbamylase.


Effects of furazolidone on the macromolecular synthesis and morphology of Vibrio cholerae cells.


Bacterial glycolipids.

Bacterial glycolipids.


Evidence for channeling of homoserine in Salmonella typhimurium.


Major malformations of the central nervous system in Hungary.


A graphic guide for clinical management of latent syphilis. A graphic luetic record form is used as a guide to physicians in diagnosis and management of latent syphilis. The form provides a uniform method of recording laboratory and clinical findings as well as treatment. It facilitates checking progress and forwarding of information necessary to assure continuity in treatment of patients with latent syphilis who are transferred to other medical facilities. It is designed primarily as a guide to the clinician who does not specialize in the treatment of syphilis.


Secondary syphilis misdiagnosed as a lymphoma.


The hyperlipoproteinemias. A simplified classification and approach to therapy. It is now clear that the various hyperlipidemias represent a heterogenous group of disorders, each having various clinical and laboratory characteristics, prognosis and treatment. The three disorders commonly associated with premature atherosclerotic vascular disease are Type II (hyperbetalipoproteinemia), Type III ("broad beta" or "floating beta" disease) and Type IV (hyperprebetalipoproteinemia or, endogenous hypertriglyceridemia). The diagnosis of each of these three disorders can be suggested by the fasting serum cholesterol level and the appearance of the fasting serum after it has remained overnight in a refrigerator. Type II disease is characterized by a clear serum and a pronounced to moderate hypercholesterolemia. It is treated by reducing dietary cholesterol and saturated fats, increasing dietary polyunsaturated fats, and cholestyrmine. Type IV disease is characterized by a turbid serum indicating hypertriglyceridemia and a normal or only slightly elevated serum cholesterol level. It is treated with weight reduction, a low carbohydrate diet and clofibrate. Type III disease is characterized by both a turbid serum and increased cholesterol levels. It is treated with weight reduction, a low cholesterol diet and clofibrate. With the treatment of all disorders the lipid values should improve; however, with the treatment of Type III disorder both triglyceride and cholesterol levels return to normal, xanthoma resorb and there is an improvement in the peripheral blood flow, indicating that there has been amelioration of the atherosclerotic process.


Progress in the treatment of heart disease.


Personalized impression trays. 1.

Personalized impression trays. 1.


The sequence around the active-center tyrosyl of porcine carboxypeptidase B.


Pyruvate dehydrogenase component subunit structure of the Escherichia coli K 12 pyruvate dehydrogenase complex.


Sir Charles James Martin--A biographical sketch (1866-1955).


Family tension in the search for a kidney donor.


Aromatic amino acid biosynthesis in Trichophyton rubrum. 3. Exogenous studies: absence of the shikimic acid pathway.


Disseminated blastomycosis in hamsters. II. Effect of sex on susceptibility.


Hydrophobic areas on the active surface of cholinesterases.


Immunological disorders in the aetiology of lymphoreticular neoplasms.


Conditioning of allogeneic skin grafts recipients with crude and water soluble H-2 antigens derived from BP-8 murine tumor cell membranes.


Ferencz Schwartzer, pioneer of psychiatric care in Hungary. In memory of the 80th anniversary of his death.


Preliminary report: Vineland Ego Development Profile.


A modified scoring procedure for the Machover Draw A Person Test in assessing the self concept of mentally retarded subjects.


Light and electron microscopic investigations on the endocrine pancreas of the newt (Triturus v. vulgaris (L.).


Glutethimide (Doriden) poisoning. Controversies in treatment.


The intracellular transport and distribution of cysteamine phosphate derivatives. Radioautography and extractive techniques were used to analyze the transport of cysteamine phosphate and its derivatives in salamander oocytes. The quantitative relations among the processes involved - membrane permeation, enzymatic dephosphorylation, binding through mixed disulfide formation, and cytoplasmic diffusion - were elucidated. Within the detection limits, all of the intracellular material is present as dephosphorylated derivatives. Cytoplasmic diffusion is effectively slowed by binding (the "chromatographic" effect) and makes an appreciable contribution to cellular flux rates. As a consequence, one can observe by radioautography a cortical diffusion ring which spreads inward as a function of influx time, while also increasing in peak density because of the finite membrane permeability. Good agreement was found between the transport parameters determined by radioautography and those from influx data for the whole oocyte. The ratio of nuclear to cytoplasmic concentrations of the cysteamine phosphate derivatives at equilibrium is about 0.4. The nuclear membrane is, however, a negligible barrier to transport, and the asymmetry appears to arise primarily from the quantity and sulfhydryl content of the binding proteins in the two compartments.


Immunocytochemical localization of the ovine immunoglobulins IgA, IgG1, IgG1-A and IgG2: effect of gastro-intestinal parasitism in the sheep.


Is azathioprine a better immunosuppressive than 6-mercaptopurine?


A correlative study of immunological phenomena in pernicious anaemia.


The antigen-induced degranulation of basophil leucocytes from atopic subjects, studied by phase-contrast microscopy.


Immunofluorescent studies on human spermatozoa. I. The detection of different spermatozoal antibodies and their occurrence in normal and infertile women.


An improved holder for transfer of brain slices during in vitro incubation.


Quantitative culture of urine. A comparative study of semiquantitative method with the quantitative pour plate method.


Utilisation of the anticoagulant citrate from plasma by some strains of Enterobacteriaceae.


Coronary atherosclerosis. A comparison of lesions between North Indian and South African Indians.


Hepatic ascariasis.

Hepatic ascariasis.


Master of Dental Surgery: the nineteenth century degree of the Dental Society of the State of New York.


Studies on the DNA-dependent synthesis of RNA with RNA polymerase.


Clinical evaluation of a rectangular field collimating device for periapical radiography.


The stud attachment overlay denture and proprioception.


Meprobamate therapy for the myofascial pain-dysfunction (MPD) syndrome: a double-blind evaluation.


On the natural history, treatment, and prognosis of Hodgkin's disease.


The development and use of an extracellular RNA replicating system.


Chorismate mutase-prephenate dehydratase. Evidence for distinct catalytic and regulatory sites.


Marvin Curtis Korengold, M.D.

Marvin Curtis Korengold, M.D.


Effect of triamcinolone on scalp homograft tolerance.


History of the Medical Society of the District of Columbia. VII. Doctors in Court.


Parenteral medication for amnesalgesia in dentistry. A review.


The life cycle of a single-stranded DNA virus (phi-X-174).


Stereological studies on several ducts and vessels by injection methd of acrylic resin. XXVI. Arterial distribution of the parotid gland in some mammals.


Stereological studies on several ducts and vessels by injection method of acrylic resin. XXVII. Arterial distribution of the masseter muscle in some mammals.


Stereological studies of several ducts and vessels by injection method of acrylic resin. 28. On the superficial temporal artery in some mammals.


Interconvertible forms of Escherichia coli RNA polymerase. Escherichia coli RNA polymerase exists in two different forms, one less active than the other under standard assay conditions. Conversion of the active to the inactive form requires ATP-Mg(++). The reverse, inactive to active enzyme conversion, requires Mg(++). Covalently bound adenylic acid residue(s) are contained in the inactive form.


Multiple molecular species of Escherichia coli DNA polymerase. DNA polymerase activity from Escherichia coli can be demonstrated in various sized molecules ranging in molecular weight from about 10,000 to 120,000 or higher. The characterization of the smaller species is difficult because of their pronounced tendency toward aggregation; the smallest apparently aggregates most readily. The results indicate the following molecular weight classes: 10,000-20,000; 40,000-50,000; 75,000-85,000, and 100,000-120,000. The same classes were obtained with several methods of analysis of material that had been purified in a number of ways, one of which is a new DNA-acrylamide gel chromatographic procedure. The lowest molecular weight species shows no exonucleolytic activity. A proteolytic inhibitor, phenylmethyl sulfonylfluoride, did not eliminate the small active molecules, although proteolysis of high molecular weight DNA polymerase (109,000) has been shown by others to produce fragments of about 75,000 molecular weight. Either there is a naturally occurring polymerase protein of about 20,000 molecular weight, capable of aggregation with itself and with certain other molecules (e.g., exonucleases), or there are certain bonds in a large, native polymerase molecule that are especially susceptible to proteolysis without destroying activity.


Strand-specific supercoiled DNA-protein relaxation complexes: comparison of the complexes of bacterial plasmids ColE1 and ColE2. Certain bacterial plasmids can be isolated as unique complexes of supercoiled circular DNA and protein. These complexes are distinguished by the conversion of the supercoiled DNA to the relaxed or open-circular DNA form upon treatment with ionic detergents, proteases, or alkali. This report demonstrates that the open-circular DNA resulting from the pronase-induced relaxation of the complexes of colicinogenic factors E(1) (ColE(1)) and E(2) (ColE(2)) possesses a strand-specific break. In each case this break is found in the heavy strand of the DNA as defined by CsCl centrifugation in the presence of poly(U,G). In addition, the ColE(1) and ColE(2) complexes exhibit certain properties that are plasmid specific. Heat treatment, and to a lesser extent pronase treatment, inactivates the ColE(2) complex, making it insensitive to agents that formerly were capable of inducing relaxation (conversion of the DNA to the open-circular form). In contrast, the ColE(1) complex is not inactivated by these treatments. The potential role of these strand-specific relaxation complexes in DNA replication is discussed.


Chemical modifications of transfer RNA species. Desulfurization with Raney nickel. A single, modified nucleoside in Escherichia coli tRNA, 6-(3-methyl-2-butenylamino)-2-methyl-thio-9-beta-D-ribofuranosylpurine, has been desulfurized with Raney nickel to afford its probable biosynthetic precursor. The limitations of the reaction at the nucleoside and tRNA levels and its lack of inhibition of the amino acid acceptor activity of tRNA are described.


The folded genome of Escherichia coli isolated in a protein-DNA-RNA complex. The DNA of Escherichia coli has been isolated in a compact structure containing small amounts of protein and RNA and having a sedimentation coefficient of approximately 3200 S. The molecular weight of the DNA in the complex is very large (probably higher than 10(9)); the protein is predominantly core RNA polymerase; the RNA is chiefly nascent messenger and ribosomal chains. Solutions containing the complex have low viscosities; this plus its sedimentation rate suggest that the DNA is in a tightly folded conformation. The DNA unfolds after exposure to RNase or heat; this indicates that an RNA component of the complex is involved in stabilizing the structure.


Proliferation of donor spleen and bone-marrow cells in the spleens and bone marrows of unirradiated and irradiated adult mice.


Plaque-forming-cell response to H-2 antigens of mice.


Augmentation of pituitary responsiveness to LH-releasing hormone (LH-RH) by estrogen.


Evaluation of low temperature grown influenza A2-Hong Kong virus in volunteers.


Fate and effect of endotoxin derivtives in tumor-bearing mice.


The effects of streptozotocin on glucose oxidation by isolated islets of Langerhans.


The sixtieth birthday of the outstanding American physiologist Professor Samuel A. Corson.


Mycoplasma diseases of plants and insects.


Structural defects of T-even bacteriophages.


Virus-induced polykaryocytosis and the mechanism of cell fusion.


The self-assembly of spherical plant viruses.


Structure and assembly of simple RNA bacteriophages.


Modification of the American Public Health Association procedure for counting yeast and mold in cottage cheese. The American Public Health Association method for counting low numbers of yeast and mold in cottage cheese was unsatisfactory due to altered pH of the culture medium. A modification of this method is presented.


Gastric secretory and splanchnic blood flow studies in man after severe trauma and hemorrhagic shock.


Colicin typing as an epidemiological tool in the investigation of outbreaks of Shigella sonnei. Shigella sonnei has become the most frequently reported cause of shigellosis in the United States. Since Shigella subgroup D has no other serotypes, colicin production has been used as a basis for differentiating and identifying epidemiologically related strains. The results of colicin typing 115 cultures of S. sonnei from eight outbreaks of shigellosis occurring in widely separated regions of the United States support the usefulness of this technique. In each outbreak, the cultures were either of the same colicin type or were uniformly untypable. Unrelated cases yielded a variety of types. Definitions of the relative frequencies and geographic distributions of the various strains of S. sonnei in the United States await an accumulation of experience with the method.


Outer cell envelope glycoprotein from two strains of Serratia marcescens. Cell envelope glycoproteins were extracted with sodium dodecyl sulfate from isolated cell walls of two strains of Serratia marcescens and purified by gel filtration column chromatography on Sepharose 4B. There was no significant difference in the chemical composition. Both fractions contained approximately 50% proteins and 10% carbohydrates. Glucosamine and glucose were identified as the only sugar components in the carbohydrate moiety. Immunochemically they shared at least one common antigenic component with each other and possibly with their corresponding lipopolysaccharide fractions.


Identification of a pea component stimulatory for heat-stressed putrefactive anaerobe 59-123 spores. Pea extract contains a factor which improves recovery counts of heat-stressed putrefactive anaerobe spores in a complex medium up to threefold. The factor is heat-stable and nondialyzable. Most of the active principle is found in the precipitate which forms during storage of pea extract at 4 C. The precipitate disperses upon heating, is high in starch content, and retains activity after extraction with organic solvents and water. Treatment of pea extract with alpha-amylase results in complete destruction of the active principle. These observations indicate that starch is the factor in pea extract responsible for increased recovery counts of heat-stressed putrefactive anaerobe spores.


Inhibition of injured Escherichia coli by several selective agents. A population of Escherichia coli ML30 cells was exposed to a quaternary ammonium compound, and injury to the cells was measured by a comparison of counts on Trypticase Soy Agar and Violet Red Bile Agar. Substantial injury could not be detected with a minimal medium. The ingredients of Violet Red Bile Agar were tested against damaged cells. The bile salts mixture alone in the medium prevented as many injured cells from growing as did any combination of the selective agents and inhibited as many injured bacteria as were inhibited by Violet Red Bile Agar itself. These dyes and salts were similarly assayed in minimal agar, and comparable results were obtained. Individual bile salts and other potential selective agents were added to the minimal medium, and the media were tested for inhibition of injured E. coli. Sodium deoxycholate was the bile salt most inhibitory to damaged E. coli cells.


In vitro studies of alpha-carboxyl-3-thienylmethyl penicillin, a new semisynthetic penicillin. The activity of a new semisynthetic penicillin, alpha-carboxyl-3-thienylmethyl penicillin (BRL-2288) was determined against 535 clinical isolates of gram-negative bacilli, by using the tube dilution technique. Nearly 80% of isolates of Proteus spp. were inhibited by 3.12 mug or less of this antibiotic per ml. BRL-2288 was as active as ampicillin against Escherichia coli. It was slightly more active than carbenicillin or 6-(d-alpha-sulfoaminophenylacetamido)-penicillanic acid against Pseudomonas sp., with over half of the isolates being inhibited by 50 mug or less of BRL-2288 per ml. Isolates of Klebsiella sp. were routinely resistant to this antibiotic. The drug was bactericidal against most sensitive organisms. BRL-2288 was less active against large inocula. A strain of Pseudomonas sp. which developed resistance to carbenicillin also developed resistance to BRL-2288 simultaneously.


Uptake of 3H-Tetracycline by resistant and sensitive Escherichia coli. The uptakes of (3)H-tetracycline by 12 tetracycline-sensitive and 24 tetracycline-resistant Escherichia coli hospital cultures were found to be 270 and 75 nmoles of tetracycline per milliliter of cell water per 20 min, respectively. This confirms reports by other investigators who, by using only one or two cultures, suggested a relationship between tetracycline uptake and tetracycline resistance. However, minimum inhibitory concentrations of tetracycline for the cultures bore no relation to the tetracycline uptake values, suggesting that loss of tetracycline uptake may not be the primary cause of resistance. In addition there were three resistant cultures with uptake values greater than 140 and two sensitive cultures with uptakes lower than 180, raising the question of how these tetracycline-resistant cultures could grow with tetracycline at concentrations nearly as high as those found to inhibit growth of sensitive organisms. Of the tetracycline-resistant cultures, 15 were able to transfer tetracycline resistance to a recipient organism and 9 were not. Two of the cultures transferred TC-resistance to a recipient with no modification-restriction system (E. coli C) but did not transfer resistance to a recipient with a known modification-restriction system (E. coli K-12).


Reagent strips and conventional tests for acid production from mannitol and coagulase activity of Staphylococcus: a comparative study. A total of 244 Staphylococcus strains were tested simultaneously for acid production from mannitol and for coagulase activity with reagent-impregnated paper strips and with their conventional counterparts. Significant correlation was obtained with 97.9% of the strains for mannitol and with 95% for the coagulase test. The paper strip method is a combined test for both mannitol and coagulase tests, thus making it more convenient and simpler than conventional methods. The results are obtained rapidly within 6 hr by the paper strip method. However, as the paper strip method is designed for the aerobic system, the conventional tests were also carried out under aerobic conditions to compare the results.


Effects of atractyloside on the incorporation of radioactive precursors into DNA in isolated rat liver mitochondria.


Studies on the ability of norleucine to replace methionine in the initiation of protein synthesis of E. coli.


The thiol groups of Jack Bean urease.

The thiol groups of Jack Bean urease.


Pseudomonas denitrificans cytochrome cc'.


Chloride NMR studies on the zinc-binding site in E. coli alkaline phosphatase.


Behçet's syndrome.

Behçet's syndrome.


Reticulum cell lymphoma.

Reticulum cell lymphoma.


Systemic amyloidosis complicating dermatoses.


Immunofluorescent "band" test for lupus erythematosus. II. Employing skin lesions.


Relationship of long-acting thyroid stimulator to pretibial myxedema.


Dissociating activity of purified colicin E2 on the isolated membrane complex of Escherichia coli.


A portrait of the colonial physician.

A portrait of the colonial physician.


Abnormal responses of the systolic time intervals to exercise in patients with angina pectoris.


Analysis of left ventricular function by atrial pacing.


Force and kindred notions in eighteenth-century neurophysiology and medical psychology (concluded).


Chemical structure and pharmacological action: a chapter in the history of 19th century molecular pharmacology.


Non-venereal treponematosis in colonial North America.


Huglings Jackson's first encounter with the work of Paul Broca: the physiological and philosophical background.


The application of immunofluorescent technique for the identification of C. albicans.


The role of the spleen in thrombokinetics.


Black is beautiful: a reexamination of racial preference and identification.


One-stage replantation of both lungs in the dog.


Enzymatic solubilization of fish protein concentrate: batch studies applicable to continuous enzyme recycling processes.


Skiing down through the years.

Skiing down through the years.


Ribosomal proteins. XVI. Altered S4 proteins in Escherichia coli revertants from streptomycin dependence to independence.


Ribosomal proteins. XVII. Comparative studies on ribosomal proteins of four strains of Escherichia coli.


The molecular structure of the transducing particles of Salmonella phage P22. II. Density gradient analysis of DNA.


Reversion of a streptomycin-dependent strain of Escherichia coli.


Dermal mastopexy.

Dermal mastopexy.


Rotation finger flaps in reconstruction of burned hands.


Prolonged renal allograft survival in the rat across a major genetic barrier, without the use of drugs.


Observation on a congenital division of the soft palate and the uvula cured by means of an operation similar to that for a hare-lip.


Demonstration of mycobacterial lipids in bacilli separated from infected tissue.


Oral reflections of infectious diseases. II.


The year of the plague in Cape Town.

The year of the plague in Cape Town.


Everting and inverting anastomoses. An experimental study of comparative safety.


Elevated serum alkaline phosphatase levels after the administration of certain preparations of human albumin.


Computer diagnosis in gynaecology.

Computer diagnosis in gynaecology.


Retrospect on the biochemistry of plant viruses.


Lessons learnt from small molecules.

Lessons learnt from small molecules.


Cytologic studies of tumors. L. clonal proliferation of four stemlines in three hematopoietic tissues of a patient with reticulosarcoma.


Primary coliform peritonitis in an adult.


Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. The antiviral effect of 5% idoxuridine in dimethyl sulphoxide intermittently applied and of 40% idoxuridine in dimethyl sulphoxide continuously applied for four days to the lesions in patients with zoster of recent onset was studied in two double-blind controlled trials. Most, but not all, of the patients receiving intermittent active treatment had pain for a short period only. The effect of continuous treatment was striking: pain had disappeared within nine days in all the patients and healing was accelerated. The results were statistically significant.


Cerebral malaria and intravascular coagulation.


Polyamines and protein synthesis. VII. Effect of spermine on the binding of polyuridylic acid to 30S ribosomal subunits.


Factor VIII (anti-hemophilic factor).

Factor VIII (anti-hemophilic factor).


Health in the medical and other learned professions.


Salmonellosis in general practice. Observations of cases and their household in Enfield. Nine hundred and seventeen Salmonella infections in 580 households were confirmed during a laboratory study of diarrhoea in general practices in a large urban area during the years 1953-68. This was an annual incidence of about 2/10,000 population. Salmonellas were found in nearly 2% of new cases of diarrhoea investigated. Plural infections were found in 36% of the households studied and 18% of all contacts examined were shown to be infected. Among these contacts the infection rate was higher for children (24%) than for adults (16%). The duration of infection was longer than 2 months in nearly a quarter of the cases followed up, and intermittent excretion was observed in one-fifth. The commonest serotype was Salmonella typhimurium, but its incidence in the district declined especially after 1964. S. typhimurium infection provoked a severer enteritis but less general symptoms than did other salmonellas. Children were more susceptible than adults to salmonella infection, to illness and to prolonged excretion, but symptoms in index cases were as severe in adults as in children.


Salmonella isolations in abattoirs in Greece. The prevalence of salmonellas in drain swabs from three abattoirs of Athens was studied with the use of conventional methods of Salmonella isolation as well as with a new procedure which involves secondary enrichment from the usual selenite broth or Muller-Kauffmann's tetrathionate broth in Rappaport's medium slightly modified.In all groups studied the secondary enrichment in Rappaport's medium led to an increase in the number of positive swabs, in the number of Salmonella serotypes, and in the total number of strains isolated.The frequency of Salmonella isolations was higher in samples from abattoirs killing only pigs and lower in samples from abattoirs killing only cattle or only sheep.The predominant serotype in abattoirs dealing with cattle was Salmonella tennessee, and S. typhimurium in abattoirs dealing with sheep. No predominant serotype was found in samples from abattoirs dealing mostly with pigs.S. abony, S. drypool, S. emek, S. indiana, S. muenchen and S. tennessee were isolated for the first time in Greece.


Serotypes of sex pili.

Serotypes of sex pili. There are situations in which direct observation of the attachment of antibody molecules may be the simplest method of detecting antigen-antibody reactions. Applied to the study of the sex pili determined by a number of transmissible bacterial plasmids, the method has distinguished four serotypes in the F-like class and two in the I-like class. Antibody was usually attached haphazardly to the pili; however, in a few cases a regular periodicity could be observed. When few antibody molecules were attached, they could frequently be individually resolved and in certain antibody-pilus combinations large antibody molecules, tentatively identified as IgM, could be seen to predominate.


Renal transplantation in Australia.

Renal transplantation in Australia.


Escherichia coli mutants with temperature-sensitive synthesis of DNA.


Hyperacute renal rejection in goats.

Hyperacute renal rejection in goats.


The Melkerssen syndrome.

The Melkerssen syndrome.


Teratology Society membership.

Teratology Society membership.


Helminthiasis. Nematode infections.

Helminthiasis. Nematode infections.


Toxicity and naturally occurring chemicals in food.


Studies in postmortem bacteriology. I. Necropsy sterility in three patients as long as thirty-five days postmortem.


Food allergies.

Food allergies.


Carl Bernard Lechner, M.D. 1908-1970.

Carl Bernard Lechner, M.D. 1908-1970.


Conflicting reports in medical literature.


Infectious bovine keratoconjunctivitis induced by different experimental methods.


Swine abscesses caused by Lancefield's group E streptococci. 8. Specificity of the precipitin test for their detection with relation to streptococcal antigens of groups A and G.


Bacteriolysis and inhibition of gram-positive bacteria by components of Streptococcus zymogenes lysin. The ability of the A and L components of Streptococcus zymogenes lysin to cause lysis or to inhibit growth of a variety of gram-positive bacteria has been examined. Frank lysis of some, but not all, strains of S. faecalis, S. faecium, and S. liquefaciens by L component alone was demonstrated. None of the strains of these species was lysed by A component alone. S. durans was not lysed by either component. Inhibition of growth of all enterococcal strains by both A substance-producing and L substance-producing mutants of S. zymogenes was also demonstrated. However, inhibition by the A substance producer was markedly less than by the L substance producer. Inhibition of the growth of a number of other gram-positive genera by both A and L mutants was also noted.


Mycotoxins. A menace of moulds.

Mycotoxins. A menace of moulds.