Contributions to the history of psychology. XII. Wayward history: F.C. Donders (1818-1889) and the timing of mental operations.


DNA ligase mutants of Escherichia coli.

DNA ligase mutants of Escherichia coli. A procedure is described for the isolation of Escherichia coli mutants with either excess or deficient DNA ligase activity. A mutant that overproduces DNA ligase supports the growth of ligase-defective (gene 30 mutant) T4 phages. Even T4 rII-gene 30 double mutants, which are able to grow in normal E. coli, cannot grow in cells deficient in DNA ligase. A functional DNA ligase, supplied either by the phage or the host, thus seems to be required for T4 growth. An E. coli strain that makes a temperature-sensitive DNA ligase becomes radiation-sensitive at high temperature, but otherwise grows normally and shows no obvious defect in DNA replication.


Diazepam as an induction agent for patients with cardiopulmonary disease.


The ultrastructure, based on stereoscan observations, of the oral sucker of the cercaria of Schistosoma mansoni with special reference to penetration.


Heat resistance in milk of some strains of group D streptococci from pasteurised milk and the influence exerted on their growth by selective media.


Another type of Clostridium botulinum.

Another type of Clostridium botulinum.


An in vitro comparison of colicines K and V and some therapeutic antibiotics.


Mechanism of conjugation in bacteria. I. Effect of chloramphenicol on conjugation in Escherichia coli K-12.


Isolation of a rare biochemical variant of Shigella boydii 1.


A simple micromethod of preparing peripheral leukocytes and platelets for electron microscopy.


Isoelectric focusing of Clostridium botulinum type A toxin.


Studies on the antimalarial property of 4-methoxy-6-sulfanilamido-pyrimidine monohydrate (sulfamonomethoxine: DJ-1550) and on its effect on the chloroquine-resistant malaria.


Detection in chicken and human sera of antibody against herpes type virus from a chicken with Marek's disease and EB virus demonstrated by the indirect immunofluorescence test.


Propagation of herpes type virus isolated from chickens with Marek's disease in Japanese quail embryo fibroblasts.


Melting of DNA: its study and application as a research method.


The tRNA pyrophosphorylase activity of Escherichia coli. A study on substrate specificity.


Replication of the single stranded DNA bacteriophage M 13. Intracellular flow of parental DNA and transfer to progeny particles.


Urinary infections: a selective review and some observations.


Inability of Escherichia coli B to incorporate added deoxycytidine, deoxyandenosine, and deoxyguanosine into DNA.


Hyponatremia secondary to ultrasonic aerosol therapy in the newborn infant.


Treatment of childhood acute lymphocytic leukemia.


Beethoven's deafness.

Beethoven's deafness.


The red cell, 2,3-diphosphoglycerate, and tissue oxygen release.


The chemical compositions of the cell wall of Salmonella typhimurium affecting the clearance-rate in mouse; influence of specific antibody.


Integration of chloramphenicol-resistance genes of an R factor into various sites of an Escherichia coli chromosome.


Effect of Escherichia coli and its endotoxin on the intravenous infection of mice with Nocardia asteroides.


A bacteriocin induced from a strain of Shigella sonnei.


Doctors afield. Charles Robinson.

Doctors afield. Charles Robinson.


Physiologic jaundice: the enterohepatic circulation of bilirubin.


Howard Burnham Sprague, 1895-1970.

Howard Burnham Sprague, 1895-1970.


The role of ammonia production and excretion in regulation of acid-base balance.


John Hilton's contributions on atlanto-axial disease--a forgotten chapter in the history of neurosurgery.


Chemical and bacteriological studies of the photochemical reaction product of ammonium hexachloroiridate. IV.


Retention of human properties by a xenografted human colonic tumor, GW-77, propagated in unconditioned hamsters.


Death of Mycobacterium leprae in mice, and the additional effect of dapsone administration.


An immunofluorescent focus assay for gross leukemia virus.


Inhibition of platelet adhesion to collagen by sulfhydryl inhibitors.


Circadian pattern of bioassayable and radiommunoassayable growth hormone in the pituitary of female rats.


Growth and maintenance of glomerular cells in vitro.


Interrelated transformations of Rousseau's life and of western culture of his time.


The Dalbo resilient hinge joint.

The Dalbo resilient hinge joint.


Important news for your patient, to whom you have just given his first denture.


In memoriam: Julius Nelson, 1896-1969.

In memoriam: Julius Nelson, 1896-1969.


Use of attachments in the anchorage of full dentures.


The advantages of precision attachments in the construction of unilateral distal extension partial prosthesis.


Rescuing removable partial denture abutments.


The distal extension removable partial denture: abutment tooth considerations.


Silver plated dies in crown and bridge construction.


Case reports: uses of internal clip attachment.


Use of hollow plastic sprues in casting procedures.


Directory Chicago Dental Society.

Directory Chicago Dental Society.


Permeation of testosterone through silicone rubber membranes.


Temporary occlusion of ductus deferens.

Temporary occlusion of ductus deferens.


Experimental ascending Escherichia coli pyelonephritis in the rat.


Jean Zuléma Amussat (1796-1856): forerunner of modern urologic instruments.


Membership Directory--1970 California Dental Association.


Karl Friedrich Burdach and his place in the history of neuroanatomy.


A disposable radiopaque grid for percutaneous renal biopsy.


Refluxing ureteral stump with pseudocyst formation: a complication of renal homotransplantation.


Antibacterial activity of rat vesical mucosa.


Experimental investigations of bladder regeneration using teflon-felt as a bladder wall substitute.


On the nature of cystitis follicularis.

On the nature of cystitis follicularis.


Familial vesicoureteral reflux.

Familial vesicoureteral reflux.


The severed canine posterior urethra: a study of two distinct methods of repair.


Surgical correction of vesicoureteral reflux in children: results with the use of a single standard technique.


American Academy of Implant Dentistry. Directory of Membership.


Meningitis: special techniques in treatment.


The telescopic system in the dental practice. Maxillary telescope denture.


Disinfection with ultraviolet rays.

Disinfection with ultraviolet rays.


Preprosthetic mandibular augmentation.

Preprosthetic mandibular augmentation.


Veterans Administration dental fee schedule.


Cast dowel and core techniques.

Cast dowel and core techniques.


A prophet honored. Lillian D. Wald.

A prophet honored. Lillian D. Wald.


Books of the year.

Books of the year.


Otoplasty goals and principles.

Otoplasty goals and principles.


Hair transplants. Long-term results and new advances.


Vascular pedicled island flaps. Use in head and neck reconstructive surgery.


Flaps and grafts in head and neck surgery.


A controlled study of adenotonsillectomy.


The arms of the colleges of surgeons. I. The arms and mace of the Royal Australasian College of Surgeons.


Sphere of influence: the surgeon in a developing country.


Kidney preservation for transportation. IV. Eight-thousand-mile international air transport.


Sudden death in a mare due to a malignant lymphoma.


The history of the University of Sydney, the Faculty of Veterinary Science and the Post-Graduate Foundation in veterinary science.


Effects of decaborane on gastric secretion in the Shay rat.


Malakoplakia of the bladder with recurrent passage of pseudo-tumour fragments over eight years.


Some effects of Escherichia coli enterotoxin on fluid and electrolyte transfer in calf small intestine.


Benign tracheal stenosis.

Benign tracheal stenosis.


Conquest of microbic disease by drugs.

Conquest of microbic disease by drugs.


New drugs and changing mortality from non-infectious disease in England and Wales.


The predictive value for man of toxicological tests of drugs in laboratory animals.


Social implications of recent advances in psychopharmacology.


Problems of food additives, with special reference to cyclamates.


Possible hazards to man from the use of drugs in and on animals.


The conduct of initial drug studies in man.


Standards and specifications for drugs.

Standards and specifications for drugs.


Pattern of drug-induced disease in the community. An unsolved enigma.


Abuse of drugs by the public and by doctors.


Deaths in asthma: a therapeutic misadventure?


The role of the Committee on Safety of Drugs.


The preparation of insoluble, matrix-supported derivatives of asparaginase for use in cancer therapy.


A comparison between granulomatosis and lymphoreticular neoplasia in Diemictylus viridescens and Xenopus laevis.


The leukemogenic action of phorbol.

The leukemogenic action of phorbol.


Renin excretion in patients with renal disease.


Sequelae following the use of eugenol or non-eugenol dressings after gingivectomy and subgingival curettage.


Functional evaluation of immediately replanted and 24 hour preserved and replanted lungs after longer than one year.


Further investigations of actinomycetes by scanning electron microscopy.


The medical practitioner in Anglo-Saxon England.


The ultrastructure of the juxtaglomerular apparatus as disclosed by three-dimensional reconstructions from serial sections. The anatomical relationship between the tubular and vascular components.


Charles George McDonald.

Charles George McDonald.


The use of hypnosis in general and obstetric practice.


Zacharias Wechsler.

Zacharias Wechsler.


The discovery of childhood. A background to paediatrics.


Histopathological examination of the myocardium after homotransplantation in dogs.


Adult burns in Melbourne. A five-year survey.


Louis Jabour.

Louis Jabour.


The sociology of technology.

The sociology of technology.


Unmaking otiose proteins.

Unmaking otiose proteins.


In vivo degradation of nonsense fragments in E. coli.


Gastrin and its activities.

Gastrin and its activities.


In vivo degradation of mutant lac repressor.


Temperature sensitive mutant of the DNA replication system in Escherichia coli.


Facilitation of rat mammary tumour growth by BCG.


Skin grafting and the treatment of burns.


Salmonellosis of mice: some characteristics of a heat-treated Salmonella typhimurium vaccine.


Otoneurology.

Otoneurology.


Epilepsy.

Epilepsy.


The autonomic nervous system.

The autonomic nervous system.


Cerebrospinal fluid.

Cerebrospinal fluid.


Surgery of the spinal column and cord.

Surgery of the spinal column and cord.


Trauma to the central nervous system.

Trauma to the central nervous system.


Brain tumors.

Brain tumors.


Clinical psychiatry.

Clinical psychiatry.


Criminal psychopathology.

Criminal psychopathology.


Child psychiatry.

Child psychiatry.


Regional physiology of the central nervous system.


Family therapy.

Family therapy.


Psychosomatic medicine.

Psychosomatic medicine.


Psychoanalysis.

Psychoanalysis.


Effects of infused tryptamine in man.

Effects of infused tryptamine in man.


Flow of ribosomal precursor RNA along different structural sites during chloramphenicol treatment of E. coli.


Human corneal donor material. A method of examination before keratoplasty.


Suture toxicity in the germfree guinea pig.


History of the section on ophthalmology of the American Medical Association. A progress report.


The orbit.

The orbit.


Haloacetol phosphates. Characterization of the active site of rabbit muscle triose phosphate isomerase.


Studies with aspartate transcarbamylase.


Synthesis of muramic acid 6-phosphate (2-amino-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucose 6-(dihydrogen phosphate)).


Interchain disulfide bridges of guinea pig gamma-2-immunoglobulin.


Some sources of error in the use of the projective method for the measurement of moral judgement.


Circulation of amniotic fluid: a review.


A retrospective study of bacillary dysentery.


The life of Gregor Johann Mendel--tragic or not?


The immunoglobulin class of autoantibody-containing cells in the gastric mucosa.


"To speke of phisik and of surgerye".

"To speke of phisik and of surgerye".


Level of aspiration, risk-taking behavior, and projective test performance: a search for coherence.


Evaluation of the figure drawing technique: reliability, factorial structure, and diagnostic usefulness.


Psychodiagnostic training in the academic setting: past and present.


Inactivation of bacterial spores by hydrostatic pressure.


The distribution of 2-keto-3-deoxy-octonic acid in bacterial walls.


The nutrition of Zymomonas anaerobia.

The nutrition of Zymomonas anaerobia.


Recent developments in the study of feeding and drinking in animals.


Overall controls on the biosynthesis of ribosomes in growing bacteria.


Hydrocortisone and phytohemagglutinin effect upon the RNA synthesis in the aggregate enzyme of human lymphocytes.


Purification of 3-phosphoserine-alpha-ketoglutarate transaminase from Escherichia coli B.


Computer calculation of two target trajectory during stereotaxic surgery.


Current concepts of iron metabolism and the iron deficiency anemias.


Nutrition and mental development.

Nutrition and mental development.


Nutrition and liver disease. Practical considerations.


Current concepts on trace minerals. Clinical considerations.


Nutrition and endocrine disease.

Nutrition and endocrine disease.


Metabolic studies of human obesity.

Metabolic studies of human obesity.


Measurement of cardiac output by thermal dilution. II. A new computer for rapid, convenient determinations.


New knowledge of nutrition and dental health.


Play--the language of children.

Play--the language of children.


Amitriptyline in emotional states at the menopause.


The surface tension of saliva.

The surface tension of saliva.


Fetal and maternal outcome in asymptomatic bacilluria of pregnancy. Effects on isohemagglutinin titers.


Factors influencing skin graft survival from donors with Ehrlich ascites tumor.


Presentation of the Howland Award of Josef Warkany.


Acceptance of the Howland Award.

Acceptance of the Howland Award.


Computers in medicine in the decade of the 1970's.


ECG reporting by computer.

ECG reporting by computer.


Flow charts, diagnostic keys, and algorithms in the diagnosis of dysphagia.


Laboratory identification of etiologic agents of bacterial meningitis.


Effect of insulin antibodies on glucose metabolism and on islets of Langerhans in neonatal rats.


The fine structure of fetal Tay-Sachs disease.


A histologic reappraisal of the thymus in myasthenia gravis. A correlative study of thymic pathology and response to thymectomy.


Studies on the reaction of the aminoacyl-tRNA-Tu-GTP complex with ribosomal subunits.


Inhibition of adsorption and replication of the RNA-phage MS-2 in Escherichia coli C 3000 by levallorphan.


Effects of the host-cell repair system on bacteriophage reproduction.


DNA polymerase as a requirement for the maintenance of the bacterial plasmid colicinogenic factor E1.


The occurrence of polyadenylate sequences in bacteria and yeast.


Complex formation of fusidic acid with G factor, ribosome and guanosine nucleotide.


A new DNA polymerase activity of Escherichia coli. I. Purification and properties of the activity present in E. coli polA1.


A new DNA polymerase acitvity of Escherichia coli. II. Properties of the enzyme purified from wild-type E. coli and DNA-ts mutants.


Limited genetic and functional participation in multiple infections by UV-irradiated wild-type T4 phages in competition with one unirradiated helper phage.


The eccentricity of vermilion deficiencies in Drosophila melanogaster.


Infected infarcts of the testis: a study of 18 cases preceded by pyogenic epididymoorchitis. Eighteen cases of infected infarcts of the testis are presented, and evidence is put forward that these result from venous occlusions in the epididymis and cord. The venous lesions probably result from thrombosis during the course of an attack of epididymoorchitis. Granulomatous orchitis was present in some part of half of the orchidectomy specimens, and the clinical histories, bacteriological findings, and histological data all suggest that this form of inflammation results from pyogenic infection of the testicle. What the factor is which determines whether the inflammation is granulomatous or not is unknown.


A dehydration and celloidin impregnation cycle for central nervous system material using tissue-processing apparatus (Histokinette).


D.W.W. Henderson, 1903-1968.

D.W.W. Henderson, 1903-1968.


Effect of aliphatic polyamines on growth and macromolecular syntheses in bacteria.


A comparison of two techniques for counting cellulolytic rumen bacteria.


Recovery of bacteria from damages induced by heat.


Chromosomal location of host specificity in Salmonella typhimurium.


Maternal modification of antigenicity: an immunologic mechanism to ensure survival of mammalian fetuses.


Pet association with selected human cancers: a household questionnaire survey.


The significance of bronchial circulation in lung transplantation.


"Dark-field" illumination for micro-surgical operations on chick blastoderms in vitro.


Further genetic mapping of the phoA-phoR region for alkaline phosphatase synthesis in Escherichia coli K 12.


Pleiotropic effects of de-repressed bacterial sex factors on colicinogeny and cell wall structure.


Current concepts: marihuana--a medical review.


Viability and function of preserved red cells.


A prediction fulfilled.

A prediction fulfilled.


Purification and properties of initiation factor F3.


Transfer RNA methylases and cancer.

Transfer RNA methylases and cancer.


Activity of initiation factor F3 in dissociating Escherichia coli ribosomes.


Incidence of river water of Escherichia coli containing R factors.


Specific in vitro cytotoxicity of thymus-derived lymphocytes sensitized to alloantigens.


Isolation of chloroplast envelope membranes.


Citation idiosyncrasies.

Citation idiosyncrasies.


Professor T.K. Walker.

Professor T.K. Walker.


Semiconductor nuclear radiation detectors.


Chemotherapy of chronic respiratory infections using cephaloridine.


Clinical experience with cephalexin in New Zealand.


A method for inducing experimental urinary tract infections in the rat and its use in experimental chemotherapy.


Clinical evaluation of cephalexin in urinary tract infection.


The effect of some cephalosporins on Escherichia coli.


The treatment of urinary infection by means of a single dose of cephaloridine.


Cephalexin in chronic and recurrent urinary infections: laboratory and clinical studies.


Combining cephaloridine and streptomycin for the treatment and prophylaxis of neonatal infections.


Some cephalosporins in clinical use and their structure-activity relationships.


Obesity: some current views regarding its aetiology.


Preparation of antigen for the indirect fluorescent antibody test in diagnosis of mycoplasma pneumoniae infection (A technical report).


Influence of intestinal strangulation fluid from rats on the serum sensitivity of E. coli.


The inflammatory reaction and urinary leucocytes in ascending urinary-tract infections. An experimental study on rabbits infected with Proteus vulgaris X 19 and Escherichia coli 06.


Host defence reactions during intestinal strangulation obstruction in germfree rats.


Immunoelectrophoretic patterns of extracts from all Excherichia coli O and K antigen test strains.


Comparison of different methods for serial dilution used in serological routine work.


The demonstration of Treponema pallidum with fluorescent antibody techniques in the primary stage of syphilis.


A comparison between chemical and bacteriological tests for bacteruria.


Bacteria that can be isolated and aren't.


Timely topics in microbiology: mycology, 1967-1969.


Hemodynamic effects of low doses of norepinephrine in the conscious dog.


Morphology of renal medulla in water diuresis and vasopressin-induced antidiuresis.


Computer analysis in surgical investigation facilitated by optically scanned input.


Pancreatic function after normothermic ischemia. II. Cadaveric transplantation.


Late sequelae of blind intestinal pouches.


Primary carcinoma of the gallbladder. A ten year review.


A review of international microwave exposure guides.


Direct and indirect fluorescent antibody staining of Ophiobolus graminis Sacc. in culture and in the rhizosphere of cereal plants.


Hyphomicrobia and the oxidation of manganesse in aquatic ecosystems.


Iron deficiency and porphyrin formation by Arthrobacter globiformis.


Growth of a water strain of Leptospira in synthetic media.


A comparison of some methods for estimating the area under a dye dilution curve.


Folic acid in folate-deficient patients with epilepsy. A double-blind trial using folic acid 15 mg. daily and identical placebo was carried out in 51 epileptic patients having a serum folate level below 3.6 ng./ml. Treatment was for a minimum of six months and in 41 patients was for more than one year. There were no significant changes in the frequency of seizures, behaviour, and personality, or in a number of cognitive functions.


Fine continuous-feed aneurysm needle.

Fine continuous-feed aneurysm needle.


Immunosuppressive drugs. I.

Immunosuppressive drugs. I.


Allergy to iprindole (prondol) with hepatotoxicity.


Continuous ventilation and oedema.

Continuous ventilation and oedema.


Correlation of toxic and non-toxic strains of Clostridium botulinum by DNA composition and homology.


The presence of N2-fixing bacteria in the intestines of man and animals.


In memoriam, H.W. Florey: an episode.

In memoriam, H.W. Florey: an episode.


Mutants of Streptomyces coelicolor defective in sporulation.


A safe peritoneal access device for repeated peritoneal dialysis.


Nicholas Copernicus and the inception of bread-buttering.


Supplemental folates in the therapy of Plasmodium falciparum malaria.


Tropical diarrhea in Vietnam--a controlled study of cholestyramine therapy.


The computer as a consultant.

The computer as a consultant.


No new interactions.

No new interactions.


Long erm persistence of parathion in soil.


Incomplete knowedge.

Incomplete knowedge.


Specific chromosome anomaly associated with autonomous and cancerous development in man.


Host specificity of Brazilian strains of Pasteurella pestis.


Rupture of the aorta produced in the hamster by anti-ovulatory progestogens.


Incorporation of uridine into polysomes of mouse brain during extinction.


Olfactory imprinting in a precocial mammal.


Turnover of basic protein of rat brain.

Turnover of basic protein of rat brain.


Denervation in murine dystrophy.

Denervation in murine dystrophy.


Ultrastructural localization of pemphigus autoantibodies within e epidermis.


Evaporation of DDT.

Evaporation of DDT.


DDT movement from adipocyte to muscle cell during lipid utilization.


Of mice and mens.

Of mice and mens.


Darin shares with Eve and Adam.

Darin shares with Eve and Adam.


Cleaning up for Sweden, 1972.

Cleaning up for Sweden, 1972.


Harvard's criteria.

Harvard's criteria.


Th origins of hypodermic medication.

Th origins of hypodermic medication.


Historical aspects of burn management.

Historical aspects of burn management.


The metabolic sequelae of burn trauma.

The metabolic sequelae of burn trauma.


The response of the reticuloendothelial system to thermal injury.


Caloric and fluid losses through the burn wound.


The body-weight burn budget. Basic fluid therapy for the early burn.


Indications for early excision.

Indications for early excision.


Absolute isolation in burn care.

Absolute isolation in burn care.


The use of mesh grafting in treating burns.


A reduction of Pseudomonas septicemias in burned patients by the immune process.


The role of physical medicine in the treatment of burns.


Child abuse by burning.

Child abuse by burning.


Present concepts in the management of major electrical injury.


Specialized burn care.

Specialized burn care.


National Burn Information Exchange.

National Burn Information Exchange.


Quin's corner is vacant.

Quin's corner is vacant.


Hormonal control of fetal development and metabolism.


Disaccharidase deficiency.

Disaccharidase deficiency.


Physiological aspects of mammalian breath-hold diving: a review.


AAO President Terry addresses Argentina Congress.


A consideration of two assumptions underlying Fiedler's contingency model for prediction of leadership effectiveness.


Pseudo-intermittent claudication.

Pseudo-intermittent claudication.


Biometric guides to the design of complete dentures.


Surgery in haemophilia and allied disorders.


The specificity of molecular hybridization reactions.


Multienzyme systems.

Multienzyme systems.


Automated counting of microbial colonies. The time required for direct counting of colonies on agar plates for estimating population density of viable microorganisms has precluded studies requiring measurement of such a parameter. Bowman, Blume, and Vurek have described a photo-electrical capillary tube scanner which automates the counting. Results obtained with an instrument similar to that of Bowman et al. have been intensively analyzed with respect to precision and accuracy. The sources of "errors" have been ascertained, and the instrument's potentialities and limitations are discussed.


Specific substrates for isolation and differentiation of Azotobacter vinelandii.


Purification and properties of the cyclodextrinase of Bacillus macerans.


A monstrous growth: an historical note on carcinoma of the scrotum.


Erythema nodosum.

Erythema nodosum.


Amyloid.

Amyloid.


Dentistryand Medicaid.

Dentistryand Medicaid.


Gout and uric acid metabolism.

Gout and uric acid metabolism.


The finishing touch.

The finishing touch.


Summary of recent abstracts. V. Leishmaniasis.


Summary of recent abstracts. VI. Plague.


Dietary--tension associated with removable prosthodontics.


The blood flow measurement in the human external iliac vein.


Nasopharyngeal carcinoma (NPC). I. Types of cultures derived from tumour biopsies and non-tumorous tissues of Chinese patients with special reference to lymphoblastoid transformation.


Effect of vitamin C supplementation upon the physiological response to exercise in trained and untrained subjects.


Award of Excellence to Dr. Robinson.

Award of Excellence to Dr. Robinson.


Franciscus Maurolycus and his Photismi de Lumine, a chapter in late medieval optics.


Synthesis of protein in the mammalian epidermis.


Freud and hypnotherapy.

Freud and hypnotherapy.


Inferences from natural occurring variations in caries prevalence.


Evaluation of nutritional and dietary factors that modify animal caries.


A quantitative determination of phosphonate phosphorus in naturally occurring aminophosphonates.


International cooperative study on cardiovascular epidemiology.


Glyoxylate metabolism in the rat.

Glyoxylate metabolism in the rat.


Mothers separated from their newborn infants.


Formula feeding of normal term and low birth weight infants.


Coagulation problems in the newborn infant.


Myoglobin-facilitated oxygen diffusion: role of myoglobin in oxygen entry into muscle.


Reconstruction of saddlenose by cartilage overlay. Dr. von Mangoldt, Dresden, Germany. (Deutsche Gesell. f. chir., 29: 460, 1900).


John Keats's psychology of creative imagination.


Nonverbal, extraverbal, and autistic verbal communication in the treatment of a child tiqueur.


The chemical pathology of the affective disorders.


Herbicides in Vietnam: AAAS study finds widespread devastation.


Localization of coronary arteriovenous fistula by indicator-dilution curves.


Myocardial blood flow in coronary artery disease. Correlation with severity of disease and treadmill exercise response.


Geographic aspects of malignant lymphoma and multiple myeloma. Select comparisons involving Japan, England and the United States.


Howard T. Karsner, M.D., 1879-1970.

Howard T. Karsner, M.D., 1879-1970.


Adrenocortical lipid hyperplasia induced in rats by aniline. A histologic and electron microscopic study.


The morphogenesis of virulent Newcastle disease virus in the chick embryo. An ultrastructural study.


Caffey's disease.

Caffey's disease.


Cell-free protein synthesis at 0 degrees. An activating factor from ribosomes of a psychrophilic microorganism.


Mitochondria and calcium ion transport.

Mitochondria and calcium ion transport.


Polyamines and protein synthesis. VI. Role of spermine in aminoacyl-tRNA formation.


Mutant Hfr strains defective in transfer: restoration by F-like and I-like de-repressed R factors.


Characteristics of E. coli K12 strains carrying both an F prime and an R factor.


Genetics of a chain-forming mutant of Escherichia coli. Transduction and dominance of the envA gene mediating increased penetration to some antibacterial agents.


The sex ratio in anencephaly.

The sex ratio in anencephaly.


Dominance of streptomycin sensitivity over dependence in Escherichia coli K12 merodiploids.


Electrophoretic study of Salmonella typhimurium-Salmonella montevideo hybrids.


Isolation, characterization, and genetic analysis of osmotic mutants of Neurospora crassa.


Molecular characterization of the Drosophila genome.


Argon laser phototherapy of pseudomonas corneal ulcers.


Autotransplantation of the pancreas in sheep: insulin secretion from the transplant.


Ultrastructure of the neurohypophysis as shown by freeze-etching.


Population cytogenetics, assignment of gene loci in autosomes, karyotype-phenotype correlations. A progress report on human cytogenetics.


The isolation and properties of non-restricting mutants of two different host specificities associated with drug resistance factors.


Stability of DNA in dark-repair mutants of Escherichia coli B treated with nalidixic acid.


In vitro induction of sulfanilic acid-specific antibodies by RNA extracted from rat spleen.


Procarbazine as an immunosuppressant in animals.


Pursuing toxoplasma.

Pursuing toxoplasma.


The growth of fetal mouse skin in cell culture and transplantation to F1 mice.


Action spectrum of ultraviolet light-induced damage to nuclear DNA in vivo.


Proliferation and differentiation of pigment cells in vitro.


Reflections on abnormal colour vision and theories of colour.


Recent developments concerned with the mode of action of disodium cromoglycate (Intal).


Nursing theory, levels of nursing, and curriculum development.


Spina bifida: mother-child relationship.


Frederic David Zeman, M.D. 1894-1970.

Frederic David Zeman, M.D. 1894-1970.


Cell survival and X-ray-induced DNA degradation in Micrococcus radiodurans.


A project of complex diagnostic service using automatic computer.


Benjamin Eliasoph, M.D. 1899-1970.

Benjamin Eliasoph, M.D. 1899-1970.


Visuo-perceptive and visuo-motor performance of children with reading disabilities.


Weight as a correlate of clinical response to psychotropic drugs.


Synthesis of polypeptides directed by the RNA of phage Q beta.


The morphogenesis of bacteriophage lambda. II. Identification of the principal structural proteins.


The association of host and phage DNA with the membrane of Escherichia coli.


Synthesis of vaccinia virus "early" and "late" messenger RNA in vitro with nucleoprotein structures isolated from infected cells.


Weight changes with schizophrenic psychosis and psychotropic drug therapy.


Morphological proteins of phage lambda: identification of the major head protein as the product of gene E.


Repressor function of late phage gene.

Repressor function of late phage gene.


Multiplication of adenovirus in heterokaryocytes produced by fusion of infected permissive and nonpermissive cells.


Infection of Hyperomyzus lactucae by sowthistle yellow vein virus.


A new case of defective induction of the prophage.


The high titer extraction of T2 bacteriophage grown on cellulose membranes.


An electron microscope study of the distribution of tomato spotted wilt virus in systemically infected Datura stramonium leaves.


Training generalized imittion: variations on an historical theme.


Studies on histocompatibility in skin allotransplantaion in rabbits.


The diagnostic and epidemiologic significance of nephropathogenic Escherichia coli serotypes.


The influence of hydrochloric acid on the cell wall of Shigella sonnei phase. I.


Serologic changes in Shigella flexneri bacilli as a result of recombination with E. coli K12.


Resection of the spermatic cord in selected inguinal hernias. Twenty years of experience.


Gram-negative sepsis following operation for congenital heart disease. Diagnosis, management, and results.


Antibiotic sensitivity of bacteria isolated in the years 1966-1968.


Blood supply of healing wounds: functional and angiographic.


The genetics of the HL-A system in a caucasian Australian population and its relationship to renal transplantation.


A simple ex vivo method for evaluating the function of preserved kidneys.


Antibody-producing cells in antigenically stimulated mammary glands and in the gastro-intestinal tract of sheep.


Crushed leg (Case P70).

Crushed leg (Case P70).


Dr. Patrick J. Whelan.

Dr. Patrick J. Whelan.


Patient personality and demographic factors as predictors of early response to psychotropic drug treatment.


Enzymes in the wash-tub: pure white toxicology.


Alcohol: another intoxicating instalment.


Pesticides and proteins.

Pesticides and proteins.


DDT: friend or foe.

DDT: friend or foe.


Continuing the copper saga.

Continuing the copper saga.


The unsolved mysteries of lathyrism.

The unsolved mysteries of lathyrism.


Pathological malpraxis.

Pathological malpraxis.


Determination of cardiac output by ether dilution.


Inhibition by phenylalanine of thiazole biosynthesis in Escherichia coli. Phenylalanine inhibited thiazole biosynthesis in a thiamine-regulatory mutant of Escherichia coli, and the inhibition was overcome by tyrosine.


Pulmonary mean-transit-time blood volumes in anesthetized dogs.


Gamma-ray-induced spore germination of Dictyostelium discoideum. (60)Co gamma rays can induce germination of the spores of the cellular slime mold, Dictyostelium discoideum, in the absence of heat shock, amino acids, or bacteria food source. About 65% amoebae emergence occurs by 13 hr after a dose of 180 krad.


Purification and properties of colicin K. Colicin K was purified from Escherichia coli K-235 (Col K) as a single protein free from polysaccharide. Its molecular weight was estimated at 70,000.


Nalidixic acid-resistant auxotrophs of Escherichia coli. purB and ctr mutants of Escherichia coli are resistant to low levels of nalidixic acid.


Variant of penicillinase mediated by an R factor in Escherichia coli. The penicillinase from an Escherichia coli strain harboring an R factor R(GN823) was purified and its properties were compared with those of a known type I penicillinase mediated by R factors. The molecular weight and S(20,w) of the enzyme were 22,600 and 2.42S, respectively. The isoelectric point of the enzyme was 6.9. These values are clearly different from those of type I penicillinase. The specific activity of the enzyme was 84,700 units per mg of the purified enzyme protein, which is about 20 times higher than that of the type I penicillinase. However, similarities were observed between the enzyme and the type I-penicillinase at optimal pH (6.5 to 7.0), optimal temperature (40 to 45C), substrate specificity, Michaelis constants for penicillins and cephaloridine, and effect of inhibitors. Furthermore, antiserum against type I penicillinase showed cross-reaction against this enzyme. The enzyme was named type Ib penicillinase, and the original type I penicillinase was renamed type Ia-penicillinase.


Iron transport in Salmonella typhimurium: mutants blocked in the biosynthesis of enterobactin. A number of mutants of Salmonella typhimurium were isolated which are blocked in the biosynthesis of enterobactin, an iron chelator that is secreted by the wild-type bacteria when they are grown on low iron media. One class of these enb mutants accumulates the enterobactin precursor 2,3-dihydroxybenzoic acid, and another class does not accumulate any detectable catechol precursor. The enb mutants grow very well on a glucose-mineral salts medium. Addition of citrate, itself an iron chelator, to the medium drastically inhibits growth unless the medium is supplemented with enterobactin or iron salts. Citrate inhibits iron uptake from the medium by enb mutants; enterobactin counteracts this inhibition and also, by itself, increases iron uptake. Thus, the apparent function of enterobactin is to promote the absorption of iron from the medium by the bacteria. Transduction experiments showed that the genes for enterobactin biosynthesis are closely linked on the S. typhimurium chromosome. It is suggested that they form an operon which is repressed by the presence of iron. S. typhimurium can utilize the iron chelate ferrichrome. (Deferriferrichrome is a cyclic hexapeptide that is produced by some fungi but not by S. typhimurium.) The enb mutants use ferrichrome as an effective growth factor.


Cation transport in Serratia marcescens and Serratia marinorubra. The sodium, potassium, and magnesium ion contents of Serratia marcescens and those of its salt-tolerant relative, S. marinoruba, were determined by atomic-absorption spectrometry. The intracellular K(+) and Mg(2+) contents of both microorganisms were found to be dependent on the ionic strength of the growth or suspending medium. The Mg(2+) content of S. marinoruba was generally greater than that of S. marcescens. The Na(+) content of the cells was normally low and did not increase as the cells aged or when the cells were grown in media of high ionic strength. The transport of K(+) by resting cells suspended in hypertonic solution was studied by chemical and light-scattering techniques and was found to be more rapid in S. marcescens than in S. marinorubra. The slower rate of K(+) transport in S. marinorubra is probably related to the lower glycogen reserves found in resting cells of this microorganism. K(+) transport was found to have a pH optimum of 5.5 to 6.1 for S. marcescens, and the K(m) for K(+) was approximately 1.6 mm. Na(+) and Mg(2+) were not taken up by the cells, although the presence of Mg(2+) tended to decrease rates of K(+) uptake. Tris-(hydroxymethyl)aminomethane, routinely used for resuspending the cells, was apparently taken up by the cells at pH >7.


Conservation and transfer of Escherichia coli genetic segments by partial diploid Hfr strains of Salmonella typhosa. Heterozygous, partial diploid hybrids were obtained in a Salmonella typhosa Hfr strain by using it as the recipient in a mating with the Escherichia coli Hfr donor WR2004 (O...proA...leu). Three of these S. typhosa Hfr hybrids were observed to mobilize and transfer the diploid E. coli genes, at high frequencies, to an E. coli recipient. The gradient of transfer frequencies of E. coli markers from these S. typhosa Hfr hybrids was similar to that observed with E. coli Hfr WR2004, from which they were derived. Interrupted matings with one of these S. typhosa Hfr hybrids, designated WR4272, showed the entry times for the proA, thr(-)leu, and argB E. coli diploid markers to be identical to the times obtained for these markers with E. coli Hfr WR2004. Also, the pattern of unselected inheritance of the diploid E. coli markers of S. typhosa Hfr hybrid WR4272 was similar to that observed with the chromosomal markers of E. coli Hfr WR2004. It was concluded that S. typhosa Hfr hybrid WR4272 contains, in addition to its Salmonella genome, a physically continuous E. coli chromosomal segment which is genetically complete from proA to at least the strA locus. The two other S. typhosa Hfr hybrids, on the basis of transmission frequency gradients, appeared to contain a continuous E. coli diploid segment complete from proA through the fuc locus. Other classes of S. typhosa Hfr hybrids, derived from mating with E. coli Hfr WR2010 (O...tna...xyl), were also observed to transfer E. coli genes at high frequency.


Metabolic regulation in glucose-limited chemostat cultures of Escherichia coli. Glucose-limited chemostat cultures of Escherichia coli, growing at dilution rates above 0.3/hr, continue to grow at the restricted rate after removal of glucose restriction. In a glycogenless strain, the specific rates of increase of mass, protein, and ribonucleic acid (RNA) were equal before and after supplementation with 0.05% glucose and did not increase detectably until after 30 to 60 min. The unrestricted specific growth rate was reached after two to three doublings of cell mass. Supplementation with glucose plus 20 amino acids, but not with glucose plus vitamins or ribosides, produced an immediate increase in the specific rates of mass and RNA synthesis followed by an increase in the specific rate of protein synthesis. In a wild-type strain, synthesis of protein and RNA continued at the restricted rate after glucose supplementation, but the specific rate of increase of mass immediately increased due to rapid synthesis of glycogen. At dilution rates less than 0.3/hr, the specific rates of increase of mass, protein, and RNA increased immediately after supplementation with glucose, but did not immediately attain the unrestricted growth. The results at dilution rates greater than 0.3/hr are interpreted to mean that the regulation of a number of enzymatic reactions is entirely through control of enzyme synthesis, without modulation of enzyme function. The levels of such enzymes are controlled so that operation with zero-order kinetics precisely meets the demands for balanced growth. It was shown that glutamic dehydrogenase and glutamic-oxalacetic transaminase are regulated in this manner.


Partial purification and properties of D-desthiobiotin synthetase from Escherichia coli. d-Desthiobiotin synthetase, an enzyme that catalyzes the synthesis of d-desthiobiotin from dl-7,8-diaminopelargonic acid and HCO(3) (-), was purified 100-fold from cells of a biotin mutant strain of Escherichia coli. Adenosine triphosphate and Mg(2+) were shown, especially in purified extracts, to be obligatory for enzyme activity, although concentrations higher than 5 mm caused severe inhibition of the reaction with unpurified cell-free extracts. Adenosine diphosphate and adenosine monophosphate were shown to inhibit the reaction, but fluoride (up to 50 mm) had no detectable effect. The product of the enzyme reaction was identical to d-desthiobiotin on the basis of biological activity and chromatography. Furthermore, when H(14)CO(3) (-) was used as a substrate, the radioactive product was shown to be (14)C-desthiobiotin labeled exclusively in the ureido carbon.


Regulation of S-adenosylmethionine synthetase in Escherichia coli. Addition of methionine to the growth medium of Escherichia coli K-12 leads to a reduction in the specific activity of S-adenosylmethionine (SAM) synthetase. Thus the enzyme appears to be repressible rather than inducible. Mutant strains (probably metJ(-)) are constitutive for SAM synthetase as well as for the methionine biosynthetic enzymes, suggesting that the regulatory systems for these enzymes have at least some elements in common. Cells grown to stationary phase in complete medium, which have low specific activities of the enzymes, were routinely used for derepression experiments. The lag in growth and derepression when these cells are incubated in minimal medium is shortened by threonine. Ethionine, norleucine, and alpha-methylmethionine are poor substrates or nonsubstrates for SAM synthetase and are ineffective repressors. Selenomethionine, a better substrate for SAM synthetase than methionine, is also slightly more effective at repression than methionine. Although SAM is considered to be a likely candidate for the corepressor in the control of the methionine biosynthetic enzymes, addition of SAM to the growth medium does not cause repression. Measurement of SAM uptake shows that too little is taken into the cells to have a significant effect, even if it were active in the control system.


Interaction between histidyl transfer ribonucleic acid and the first enzyme for histidine biosynthesis of Salmonella typhimurium. Previous studies showed that the enzyme (phosphoribosyltransferase) which catalyzes the first step of the histidine pathway in Salmonella typhimurium plays a role in regulation of the histidine operon. Since histidyl transfer ribonucleic acid (His-tRNA) is required for repression of the histidine operon, we considered the possibility that the role of phosphoribosyltransferase might be realized through an interaction with His-tRNA. One prediction inherent in this idea is that the enzyme should interact with His-tRNA in vitro. Evidence is presented for such an interaction. Binding of (3)H-His-tRNA to purified phosphoribosyltransferase was tested on Sephadex columns and on nitrocellulose filters. The enzyme was found to have a high affinity for tRNA. Comparing the binding of (3)H-His-tRNA with that of tRNA aminoacylated with other (3)H-amino acids disclosed that the binding of the histidyl species of tRNA is favored over that of other species and is dependent upon magnesium-ion concentration.


Isolation and mapping of phosphotransferase mutants in Escherichia coli. Mutants of Escherichia coli K-12 defective in enzyme I or Hpr, the two common components of the phosphoenolpyruvate-dependent phosphotransferase system, were isolated by a simple, direct method. The ptsI locus, the structural gene for enzyme I, and the ptsH locus, the site of mutations leading to loss of Hpr activity, are adjacent genes and could be part of a single operon. These two genes lie between the purC and supN markers in the order: strA... guaB-purC-ptsI-ptsH-supN-dsdA... his.


Response of an Escherichia coli-bound fluorescent probe to colicin E1. The fluorescent probe, 8-anilino-1-napthalenesulfonate (ANS) binds to Escherichia coli, showing an enhanced fluorescence. The interaction of colicin E1 with sensitive cells causes an increase of about 100% in the fluorescence of the bound ANS, and this change at equilibrium has an apparent "all-or-none" nature as a function of E1 multiplicity. Approximately 6 to 8% of the ANS is bound to the cells at equilibrium. The colicin E1-induced fluorescence increase can be attributed partly to an increase in ANS binding and partly to an increase in the fluorescence yield of the bound ANS. The kinetics of the E1-induced fluorescence increase in sensitive cells are very similar to those of the adenosine triphosphate decrease. The phosphorylation uncoupler p-trifluoromethoxy-carbonylcyanidephenylhydrazone also causes a large change in the fluorescence of bound ANS. Colicin E2 or E3 does not cause any fluorescence change, nor does colicin E1 cause fluorescence change with a colicinogenic strain. ANS appears to be a probe of structural or conformational change in the cell envelope that is closely associated with the colicin E1-induced adenosine triphosphate decrease.


Elimination of sex factors in Escherichia coli by urea. Eliminatory action of urea on the sex factor (F) in Escherichia coli K-12 strains is reported. Growth of E. coli harboring F or F'8 (F-gal) factors in Penassay Broth containing urea led to the loss of these genetic elements and yielded F(-) cells. Appearance of F(-) cells among survivors was already observed when the culture was in the very early stage of exponential phase. However, frequencies of F(-) cells formed did not increase much as a function of the incubation time. Unusual F(+) or F'8 cells which retained the ability of genetic transfer but showed resistance to M12 phage were also isolated. Addition of sucrose to broth with urea led to the favorable growth of cells in the culture and the increase, if little, of elimination frequencies of F factors by urea. These findings, coupled with other observations, suggest that urea has two separate actions in enhancing the frequency of F(-) bacteria, namely, (i) to inactivate F by direct action, such as mutation, and (ii) to select the F(-) variants by differentially inhibiting the growth of F(+).


Examination of the protein composition of the cell envelope of Escherichia coli by polyacrylamide gel electrophoresis. An envelope preparation containing the cell wall and cytoplasmic membrane of Escherichia coli was obtained by breaking the cells with a French pressure cell and sedimentating the envelope fraction by ultracentrifugation. This fraction was prepared for polyacrylamide gel electrophoresis by dissolving the protein in an acidified N,N'-dimethylformamide, removing lipids by gel filtration in the same organic solvent and removing the solvent by dialysis against aqueous urea solutions. More than 80% of the total protein of the envelope fraction was recovered in soluble form. Electrophoresis on sodium dodecyl sulfate-containing gels yielded from 20 to 30 well-resolved bands of protein. One major protein band was observed on the gels. This protein had a molecular weight of 44,000 and accounted for as much as 40% of the total protein of the envelope fraction. A double-labeling technique was used to examine the protein composition of the envelope fraction from cells grown under different sets of conditions which result in large changes in the levels of membrane-bound oxidative enzymes. These changes in growth conditions resulted in only minor alterations in the protein profiles observed on the gels, suggesting that this organism is able to adapt to changes in growth environment with only minor modifications of the major proteins of the cell envelope.


Gliding motility mutants of Myxococcus xanthus. Two gliding motility mutants of Myxococcus xanthus are described. The semimotile mutant (SM) originated by high-frequency segregation from the motile FB(t) strain. Segregation was enhanced by acridine dye treatment. SM cells glide only when apposed to other cells in a swarm. The nonmotile strain (NM) originated by mutation from SM. NM cells neither glide individually nor cooperatively. FB(t), SM, and NM are indistinguishable with respect to fine structure, vegetative growth rate, glycerol-induced microcyst formation, spheroplasting, bacteriophage sensitivity, and responses to light. The motility mutants are more resistant to penicillin and more sensitive to actinomycin D than is the gliding wild type. The NM mutant is also a morphogenetic mutant; it is unable to form fruiting bodies.


Genetic and molecular characteristics of X-ray-sensitive mutants of Escherichia coli defective in repair synthesis. Alleles responsible for X-ray-sensitive characteristics of three mutants of Escherichia coli B, which were also sensitive to ultraviolet (UV) irradiation, were mapped near metE locus, and named res-1, res-2, and res-3. All the res(-) mutants showed no host cell reactivability (Hcr(-)) for transducing deoxyribonucleic acid (DNA) of P1 phage irradiated by UV but they were Hcr(+) for infective DNA of P1 phage. Furthermore, they showed no detectable activity of DNA polymerase. Characteristics of allele res-1 were studied in detail. The mutant res-1 uvr(+) showed an extensive degradation of DNA after UV irradiation. Double mutants carrying res-1 uvrA(-), res-1 uvrB(-), and res-1 uvrC(-) showed no marked increase in UV sensitivity beyond that of the uvr(-) single mutants and only negligible UV-induced DNA degradation. The uvr(-) mutations showed no such suppressive effect on DNA degradation induced by X rays in these double mutants. It is concluded that res(-) mutants are defective in the second step (repair synthesis) of the excision repair process and that DNA polymerase is partly responsible for the assumed resynthesis step.


Xanthomatosis associated with hyperlipoproteinemia.


Influence of pancreatic duct anastomosis on function of autotransplanted canine pancreatic segments.


Inert organic liquid as a biological oxygen carrier.


Brow presentation, Royal Hospital for Women, Paddington, 1950-1965, and review of literature.


Thrombolytic therapy with streptokinase.


Thermodynamics, chemical reactions and molecular biology.


New method for measuring density of seawater.


Lymphocytes in rheumatoid arthritis.

Lymphocytes in rheumatoid arthritis.


Decreased proliferative activity of erythroblasts in granulocytic stem cell leukemia.


Mitochondrial changes in preoptic neurons after capsaicin desensitization of the hypothalamic thermodetectors in rats.


Competitive hybridization with brain RNA fails to confirm new RNA induced by learning.


The in vivo effects of semipermeable microcapsules containing L-asparaginase on 6C3HED lymphosarcoma.


Selective neurone death as a possible memory mechanism.


Preparation of biologically active plague murine toxins labelled with 75Se-methionine.


Additive Edman degradation to sequence small peptides.


Detection of latent fingerprints with 35SO2.


Distribution of pethidine and chlorpromazine in maternal, foetal and neonatal biological fluids.


Sensory feedback in regulation of body weight: is there a ponderostat?


Environmental DDT and the genetics of natural populations.


Effects of imprinting on uracil incorporation into brain RNA in the "split-brain" chick.


Human blastocysts grown in culture.

Human blastocysts grown in culture.


Excretion of p-methoxyamphetamine administered to humans.


Medical and ecological considerations of L-dopa and 5-HTP in seeds.


In vivo difficulties.

In vivo difficulties.


Definition of intelligence.

Definition of intelligence.


Methadone increases mouse brain 5-hydroxyindoleacetic acid.


Dr. J. E. Falk.

Dr. J. E. Falk.


Clouds of smoke, confusion and oblivion.


Vital amendment.

Vital amendment.


Dissent blooms at AAAS circus.

Dissent blooms at AAAS circus.


Chemical evolution.

Chemical evolution.


Cycles in social behaviour.

Cycles in social behaviour.


Translational repression in the arginine system of Escherichia coli. Translation of bacterial mRNA, divorced from transcription, has been obtained for enzymes of arginine synthesis; evidence has been acquired for repression by arginine at the level of translation. mRNAs for acetylornithinase and ornithine transcarbamylase were accumulated by arginine starvation of argR(+) and argR(-) arginine auxotrophs derived from Escherichia coli K12. Further transcription was inhibited with rifampicin or miracil D, and enzyme formation was measured in the presence of either an excess of, or a restricted supply of, arginine. For the argR(+) strain 961, little mRNA was found without starvation; for the argR(-) strain 977, a considerable amount of mRNA was demonstrated even without starvation. There was relatively little translation for the argR(+) strain, but not for the argR(-) strain, in the presence of excess arginine, apparently due to an accelerated degradation of mRNA in the argR(+) strain under repressive conditions.


Adenosine triphosphate: glutamine synthetase adenylyltransferase of Escherichia coli: two active molecular forms. Two active forms of purified ATP:glutamine synthetase adenylyl-transferase from Escherichia coli are apparent on polyacrylamide gel electrophoresis at pH 8. The slower migrating component, which is identical to the P(I)-protein fraction of the glutamine synthetase deadenylylating enzyme system, has S(20.w) congruent with 5.1 S and a molecular weight of about 130,000. The more rapidly migrating adenylyltransferase component has S(20.w) congruent with 4.0 S and a molecular weight of about 70,000. During storage at 4 degrees C, the larger adenylyltransferase component (P(I)) converts to the smaller active unit with a concomitant loss of both P(I) deadenylylating activity and soluble protein. It is concluded that the low-molecular weight form of the adenylyltransferase is a subunit of the deadenylylating P(I)-protein.


Uptake of transfer ribonucleic acid by normal and leukemic cells. Uptake of tRNA (Escherichia coli) was demonstrated in the murine leukemia, L1210 and in a human lymphoblast (NC-37) cell lines. In both cell lines, uptake of tRNA was rapid, reaching a maximum within 45 sec, and was linear with concentration up to about 50 mug/ml. This uptake of exogenous tRNA apparently was not due to altered membrane permeability or impaired cell viability, nor to ribonuclease degradation of the macromolecule. Furthermore, about 20% of the tRNA taken up by the cells remains functional and apparently intact. This was demonstrated by: (a) acylation with E. coli aminoacyl-tRNA synthetases; (b) methylation with leukemic cell tRNA-methylases, and (c) demonstrating (14)C-labeled 4S RNA in the cytoplasmic fraction of the leukemic cells after the addition of E. coli [(14)C]tRNA. The results demonstrate that tRNA can enter mammalian cells and suggest that an energy independent, carrier-mediated, mechanism may be operative.


Ribosomal proteins. 8. Molecular weights of isolated ribosomal proteins of Escherichia coli. Molecular weights of the isolated proteins from the 30S and 50S ribosomal subunits of Escherichia coli were determined by two independent methods: polyacrylamide gel electrophoresis with sodium dodecylsulphate and equilibrium sedimentation. The values for the molecular weights determined by gel electrophoresis range from 10,900 to 65,000 for the proteins of the 30S subunit and from 9,600 to 31,500 for those of the 50S subunit, with number averages of 19,000 and 16,300, respectively, in agreement with those obtained by equilibrium sedimentation.


S100 brain protein: correlation with behavior. The brain-specific acidic protein, S100, in the pyramidal nerve cells of the hippocampus was investigated as a possible correlate to learning during transfer of handedness in rats. The amount of S100 increased during training. Intraventricular injection of antiserum against the S100 protein during the course of training prevented the rats from further increases in learned behavior but did not affect motor function in the animals. Antibodies against the S100 protein could be localized after injection by immunofluorescence, in hippocampal structures, penetrating presumably through slight ependymal lesions caused by the injection. By contrast, control animals subjected to the same training and injected with S100 antiserum that had been absorbed with S100 protein or with other antisera against gamma-globulins showed no decrease in their ability to learn. The conclusion is that the brain-specific protein, S100, is linked to the learning process, at least within the training used.


Glycyl-tRNA synthetase: an oligomeric protein containing dissimilar subunits. Glycyl-tRNA synthetase from Escherichia coli is a tetramer containing two small (33,000 daltons) and two large (80,000 daltons) subunits. The subunits can be separated and then reassembled to form active enzyme. Genetically altered glycyl-tRNA synthetases are modified in either the large or the small subunit. Wild type activity can be reconstituted in vitro by mixing extracts containing enzymes with modifications in different subunits.


Abdominal-transsacral resection and anastomosis for midrectal carcinoma.


Intestinal segments and pouches in gastrointestinal surgery.


Blood flow through different regions of long bone measured by a bone-seeking radioisotopic method.


Pulmonary capillary blood volume and lung water in pulmonary edema.


John E. Gary, M.D. 1916-1970.

John E. Gary, M.D. 1916-1970.


The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds.


A dynamic mathematical model of the chemostat.


Phillip Eisenberg, M.D.

Phillip Eisenberg, M.D.


A comparison of the number of nucleotides per unit length in Escherichia coli and phage T4 chromosomes. The grain density produced in radioautographs by fully labeled bacteriophage T(4) chromosomes was compared with the grain densities produced by fully labeled and half-labeled exponential phase Escherichia coli chromosomes. Taking into account the differing molar proportions of thymidine in E. coli and T(4) chromosomes, it was seen that the two types of chromosomes have approximately equal numbers of nucleotides per unit length, indicating that their structures are the same. Using molecular weight estimates in the literature for the T(4) and related T(2) chromosomes, and the lengths obtained in the radioautographs, the T(4) chromosome was estimated to have between 1.9 and 3.6 nucleotides/3.4 A. On the basis of these values alone, the E. coli and T(4) chromosomes could be either one Watson-Crick helix in a form about equal to or more condensed than the B form, or two helices more stretched out than the B form. The length of the T(4) chromosome was 48.7 +/- 4.1 mu when dried on the dull side of Millipore membranes and 42.3 +/- 4.8 mu on the shiny side, under the conditions used. Thus, the supporting surface apparently affects the configuration of a chromosome. Further evidence is also presented in support of the conclusion that the E. coli chromosome undergoes semi-conservative replication.


Determination of serum vitamin B12 by an isotopic method.


The history of anesthesiology in Poland.


Indications for high dose chlorpromazine therapy in chronic schizophrenia.


Feasibility of evaluating psychopharmaceutical agents in cooperative studies in private practice.


Effect of urea on the peptic proteolysis of ovalbumin.


Initiation and termination events in double stranded phi-x-DNA replication.


Regulation of the lysine biosynthetic pathway of Escherichia coli K12. Isolation, molecular weight and amino acid analysis of the lysine sensitive aspartokinase.


Deoxyribonucleoside catabolism and thymine incorporation in mutants of Escherichia coli lacking deoxyriboaldolase.


Structural investigations on the core polysaccharide of Salmonella typhimurium and the mode of attachment of the O-specific chains.


Structure of cell wall lipopolysaccharide from Salmonella typhimurium. Further studies on the linkage between O side chains and R core.


Structure of cell wall lipopolysaccharide from Salmonella typhimurium. Structure of lipopolysaccharide from a Semirough mutant.


Comparison of the lethal effects of 32P and 33P decay in E. coli and in bacteriophages.


Human bone as buried implant after enucleation.


Surgical treatment of hyperkinetic and behavior disorders.


Organization of the tonoplast in frozen-etched root tips.


A freeze-etching study of rabbit spermatozoa with particular reference to head structures.


Release of nuclear DNA template restrictions by specific polyribonucleotides. Certain synthetic homo- and copolyribonucleotide polymers are capable of releasing the DNA template restriction of isolated nuclei of rat liver cells when assayed with an excess of or in the absence of exogenous DNA polymerase. The purine homopolyribonucleotides are far more effective than are the pyrimidine polymers.


Carcinogen and microsomal membrane interactions: changes in membrane density and ability to bind nucleic acids. DNA and synthetic copolymer polyribocytidylic-polyriboguanylic acid bind to microsomal membrane. The nucleic acid-membrane complex may be detected by centrifugation in cesium chloride density gradients. The density of the nucleic acid-membrane complex and, in certain cases, the amount of nucleic acid associated with the membrane was changed in the presence of various carcinogenic chemicals.


Autoradiographic differentiation of free, bou, pure, and impure thymidine-3H.


An all-glass assembly, from commercially available parts, for fluid processing of 1-2 mm tissue blocks.


Commercial fabric softeners for facilitating sectioning of refractory paraffin-embedded tissues.


Vascular changes in the pancreaticoduodenal allograft.


The role of renal transplantation in experimental aterial hypertension in dogs.


Sterility of platelet concentrates stored at 25 C.


Bacteriologic study of platelet concentrates prepared and stored without refrigeration.


Enameloma in a prehistoric Indian skull.


Circulatory and diuretic effects of hydrochlorothiazide and reserpine in man.


Supracricoid laryngectomy.

Supracricoid laryngectomy.


The diagnosis and surgical management of congenital tracheoesophageal fistula without atresia of the esophagus.


Reconstructive surgery related to laryngology.


Santiago Riesco-MacClure, M.D. 1910-1970.


DOET (2,5-dimethoxy-4-ethylamphetamine), a new psychotropic drug. Effects of varying doses in man.


Contingent negative variation and individual differences. A new approach in brain research.


On the fidelity of phage T4-induced polynucleotide ligase in the joining of chemically synthesized deoxyribooligonucleotides.


Thiolated bases in ribosomal RNA of E. coli.


The identification of epsilon-N-(gamma-L-glutamyl)-L-lysine cross-links in native wool keratins.


Inhibition of peptide chain initiation in Escherichia coli by fusidic acid.


Evidence for preferential breakage of the minus strand of phi-X174 replicative form DNA by a T4-induced endonuclease.


A 12-S and 9-S RNA species in Strongylocentrotus purpuratus eggs.


Interference between the rec A product and an ATP-dependent exonuclease in extracts of E. coli.


Lysis of the cell membrane of Escherichia coli K12 by ionic detergents.


Cumulative effect of repeated doses of Clostridium botulinum toxin in mice and mink.


Pulpal response to dental techniques and materials.


An evaluation of the modern dental lounge chair.


Panoramic radiography.

Panoramic radiography.


Dental handpieces and rotary cutting instruments.


Dental porcelain.

Dental porcelain.


Modern concepts for the amalgam restoration.


Newer materials and techniques in prosthetic resin materials.


Restorative materials and cavity preparation design.


Elastic impression materials.

Elastic impression materials.


The estimation of the postmenstrual age: a comprehensive review.


A phase contrast cinemicrographic analysis of elevated oxygen tension effects on cell dynamics in strain L cells.


Biochemical studies on cells isolated from adult rat liver.


Bacteriuria--a diagnostic problem.

Bacteriuria--a diagnostic problem.


Weight gain with cyproheptadine hydrochloride ('Periactin'). A double blind trial in underweight medical students.


Experimental lamellar corneal grafting in buffalo calves (Bos bubalis).


George A. Dean (1904-1970).

George A. Dean (1904-1970).


Promising new drug.

Promising new drug.


Changing dinosaurs--but not in mid-stream.


L-asparaginase and human malignant disease.


Ecology of the brontosaurs.

Ecology of the brontosaurs.


Isolation and proof of structure of wildfire toxin.


Dimerization of Biebrich scarlet and the monomer-alha-chymorypsin interaction.


Handedness and birth order.

Handedness and birth order.


Patterned response to song in cricket central auditory neurone.


Trials with a transponding acoustic fish tag tracked with an electronic sector scanning sonar.


Measurement of antitumour activity of actinomycin D.


New model for schistosome granuloma formation using a sluble egg antigen and bentonite particles.


Anaemia in bursectomized irradiated chickens.


Content of ATP andADP in rabbit blastocysts.


Effects of serotonin on spontaneous ovulation in rats.


Control of accept and reect reflexes in the octopus.


Sharp increase in free circulating oestrogens immediately before parturition in sheep.


Transduction processes of movement and position sensitive cells in a crustacean limb proprioceptor.


LSD and learning.

LSD and learning.


The biologist's dilemma.

The biologist's dilemma.


Reprint communication.

Reprint communication.


Transplantation and the local physician.


Points in the experiental study of pulpalresponse to rstorative materials.


Kidney transplantations.

Kidney transplantations.


Kidney transplantation and fibrinolytic split products in serum and urine.


Immunological memory involving weak histocompatibility barriers in urodele amphibians.


Significance of allelic dosage and graft size on tolerance induction by H-1-incompatible skin grafts.


Macrophage aggregation in vitro. A model for transplantation immunity.


Route of administration of antilymphocyte serum to mice.


The migration-inhibitory factor (MIF). Effect of antilymphocytic serum on formation and performance of MIF in murine in vitro experiments.


Prognosis of renal allotransplants in patients with bilateral renal cortical necrosis.


Skin allograft survival in mice after radioprotection with sodium S-(2-aminoethyl) phosphorothioate and supralethal total body X-irradiation.


Plasma renin activity after allogenic kidney transplantation in man.


Sucrose and raffinose breakdown by Escherichia coli.


Isolation of Hfr derivative by the use of Shigella flexneri 4b-modified F factor.


Body fluid distribution in manic and depressed patients treated with lithium carbonate.


The deaf writer in America from Colonial times to 1970. II.


The entity of hemorrhagic necrosis of the intestine.


Tonogram reading by digital computer.

Tonogram reading by digital computer.


Corneal transplantation in the anterior chamber cleavage syndrome.


Congenital keratolenticular adhesion.

Congenital keratolenticular adhesion.


Research related to malocclusion. A "State-of-the-Art" workshop conducted by the Oral-Facial Growth and Development Program, The National Institute of Dental Research.


Aerobic gram-negative rods isolated from bovine udder infections.


The incidence and nature of space closure following the premature extraction of deciduous teeth: a literature study.


Hemodynamic alterations in the anesthetized pony produced by slow intravenous administration of Escherichia coli endotoxin.


Endotoxemia induced by rapid intravenous injection of Escherichia coli in anesthetized ponies.


Persistent infection of an established porcine kidney celline with selected strains of hog cholera virus.


Phage types of Escherichia coli isolated from swine.


Entebbe bat salivary gland virus: electron microscopic study of morphology and development in new born mice.


Coxsackievirus infection in skeletal muscles of mice. An electron microscopic study. I. Cell- and nucleus alterations.


Coxsackievirus infection in skeletal muscles of mice. An electron microscopic study. II. Appearance and fate of virus progeny.


Influence of cell age on production and assay of mouse interferon in L-cells.


Folate absorption and metabolism.

Folate absorption and metabolism.


Reproduction in L-phase of group A beta Haemolytic streptococci.


Nathan Clark Morse, surgeon and author, Eldora, Iowa 1877-1919.


Letter to the editor: a comparative study of shade-matching procedures.


A measurement of clasp forces on teeth.

A measurement of clasp forces on teeth.


The effect of partial denture clasp design on abutment tooth movement.


The load factor in complete denture intolerance.


Rubber-base impressions over a rubber dam.


Clinical and research advancements in cast-gold restorations.


The clinical use of polymer-coated metal pins as endosteal implants.


Acquired coronary artery fistula from nonpenetrating chest injury.


Gametocytemia in falciparum malaria. Eradication of gametocytemia with primaquine.


Peer review.

Peer review.


Surgery in Viet Nam.

Surgery in Viet Nam.


Hemodynamics and lung function during continuous positive pressure ventilation (CPPV) in acute respiratory failure.


Menstrual cycle and reproductive potential after kidney transplantation. Report of 2 patients.


The history of the tricarboxylic acid cycle.


Autobiographical sketch.

Autobiographical sketch.


Paréian and Listerian slants on infection in wounds.


Florence Nightingale: new lamps for old.


Future-time perspectives in alcoholics and normals.


Infectious infantile enteritis, yesterday and today.


Forerunner of molecular biology.

Forerunner of molecular biology.


FDA: clinically meaningful data.

FDA: clinically meaningful data.


Medical association sues California over cuts in care.


Electrical activity of the hypothalamus effects of intraventricular catecholamines. The injection of epinephrine into the third ventricle of the rat brain causes a biphasic elevation and depression in the integrated multiple-unit electrical activity of the median eminence. Activity in the arcuate nucleus decreases after the injection of the catecholamines. These changes in the integrated multiple-unit electrical activity may be related to the secretion of hormones by the anterior pituitary gland.


The surgical management of decubitus ulcers by muscle transposition.


Cause and repair of large incisional hernias.


Amphetamine abuse.

Amphetamine abuse.


Pyloric closure for difficult gastrectomies.


Ischiopagus tripus conjoined twins: case report of a successful separation.


Improved incisional biopsy technique for lesions of the head of the pancreas: construction of pancreaticoduodenostomy at biopsy site.


Osler and Philadelphia.

Osler and Philadelphia.


Memoir of Earl A. Daugherty. 1902-1968.

Memoir of Earl A. Daugherty. 1902-1968.


A tribute to Ella N. Wade.

A tribute to Ella N. Wade.


Memoir of Walter Hirst Lindsey. 1894-968.


Memoir of Leon Nathaniel Prince. 1906-1970.


Memoir of Joseph A. Scarano. 1901-1970.

Memoir of Joseph A. Scarano. 1901-1970.


Memoir of Philip F. Williams. 1884-970.

Memoir of Philip F. Williams. 1884-970.


Memoir of Samuel Simkins. 1907-1969.

Memoir of Samuel Simkins. 1907-1969.


Benjamin Rush, M.D.--1970.

Benjamin Rush, M.D.--1970.


Daniel Blain, M.D.: a biographical sketch.


Dean Winternitz and the rebirth of the Yale Medical School in the 1920's.


Effect of varying dosages of ethynodiol diacetate upon serum luteinizing hormone.


A new simple immunoassay for human chorionic gonadotropin.


Plasma lipid and lipoprotein changes during "pill-a-month" contraceptive steroid administration.


Signs and symptoms of electrolyte disorders.


Universal health insurance is the wave of the future.


Factors affecting mortality of gram-negative rod bacteremia.


Echinococcus in a zebra. Extracted and reprinted from Huxley TH: "On the anatomy and development of Echinococcus veterinorum". Zool Soc Proc 20:110-126, 1852.


Percutaneous aspiration lung biopsy.

Percutaneous aspiration lung biopsy. A total of 182 percutaneous trans-thoracic aspiration biopsies were performed in 164 patients over a three-year period. In malignant neoplasms arising in the lung the diagnostic accuracy rate was 84%. In the non-malignant localized parenchymal lesions the accuracy drops considerably unless the lesion is cystic or cavitary. Some patients with non-parenchymal lesions were selected to assess further the value of this procedure. It proved much less rewarding in lesions of the chest wall, diaphragm and also in diffuse parenchymal disease. These lesions may be more accurately identified by other methods of biopsy. Lesions presenting as a mediastinal mass are an intermediate group and in selected cases helpful information can often be obtained by small-bore needle aspiration, particularly if a pericardial, bronchogenic or thymic cyst is suspected. Recent reports have shown that the aspiration of pulmonary lesions can be utilized to obtain viable tumour cells for chemosensitivity testing. The aspiration of nodular pulmonary lesions should be considered when a diagnosis is not forthcoming from the usual investigative means, since there has been little morbidity and no mortality in the series.


On the relation between effector concentration and the rate of induced enzyme synthesis. The Jacob and Monod scheme for the regulation of enzyme formation leads to the following relation between the relative rate of enzyme synthesis alpha and cellular effector concentration E (the lower sign is for repressible systems): log (alpha/1 - alpha - alpha(b)) = +/- n log [E] + log alpha(b) +/- log K(1). This equation permits linear plotting of experimental data and the evaluation of three quantities: n, the number of effector molecules combining with a repressor molecule, K(1), the dissociation constant of this interaction and K(2)/R(t), the ratio of repressor-operator dissociation constant to total repressor concentration. Measurements on the repression of alkaline phosphatase in Escherichia coli as a function of phosphate concentration are reported and fit the proposed equation with n = 1, indicating that the binding of a single phosphate to the repressor species may be sufficient to cause repression. K(1) of this interaction was found to be 0.58 +/-0.11 x 10(-3) M. The available data regarding the enzymes of the lac operon in a variety of E. coli strains, and several other enzymes are analyzed. It is confirmed that the lac repressor interacts with 2 isopropyl thiogalactoside (IPTG) molecules to relieve repression with a K(1) = 50 +/-20 x 10(-12) M(2). In some strains, separate binding constants for the first and second IPTG molecules can be evaluated.


The fate of autoplastic and alloplastic implants in the bovine stifle joint.


The pharmacology of immunosuppressive agents.


Adverse effects of LSD: a current perspective.


Carbon monoxide and phenobarbitone: a comparison of effects on auditory flutter fusion threshold and critical flicker fusion threshold.


Development of care of elderly: tracing the history of institutional facilities.


Neota Larson Memorial Lecture Series on Social Planning and Gerontology. Foreword.


Psychological observations of obese adolescens during starvation treatment.


A review of the zinc polycarboxylate cements.


Experimental osteogenesis in embryonic and adult bone explants.


Primary prevention of rheumatic fever in Jerusalem schoolchildren. 3. Screening for heart disease by means of the PhonoCardioScan.


An aesthetic clasp for acrylic partial dentures.


Reconstruction of a mandibular defect with a homogeneous bone graft: report of case.


Angiokeratoma corporis diffusum (Fabry's disease) with renal, ocular and possibly cardiac involvement.


Halothane and hepatotoxicity: a retrospective review.


Henry H. Turner 1892-1970.

Henry H. Turner 1892-1970.


The effect of divided calcium intake on calcium metabolism.


The effect of weight loss on the growth hormone response to arginine infusion in obesity.


Rhinocerebral mucormycosis following kidney transplantation.


Triiodothyronine withdrawal test--a test of thyroid-pituitary adequacy.


Metabolic and thermal responses to Piromen in man.


Effects of HCG and human pituitary LH on steroid secretion and functional life of the human corpus luteum.


Relationship of sweat sodium concentration to blood pressure in control subjects and in patients with essential and renal hypertension.


Administration of LH-releasing hormone of human origin to man.


Projective fantasy on the CAT and CAT-H.


Projective techniques in crisis.

Projective techniques in crisis.


The relationship between the Repression-Sensitization Scale and the Incomplete Sentences Blank.


Sentence completion correlates of airline pilot attitude and proficiency.


Judging whether a patient is white or black by his Draw-A-Person Test.


Furosemide and ethacrynic acid in renal insufficiency.


Management of essential hypertension.

Management of essential hypertension.


The conservative management of acute oliguric renal failure.


Conservative management of chronic renal failure.


Peritoneal dialysis and hemodialysis.

Peritoneal dialysis and hemodialysis.


Proteinuria.

Proteinuria.


Psychiatric observations in a chronic hemodialysis program.


Anemia of renal failure.

Anemia of renal failure.


Hypertension and renal disease in pregnancy.


Diagnosis and treatment of lupus nephritis.


A clinical trial of trihydroxyethylrutoside ("varemoid") in the treatment of haemorrhoids.


Psychological factors relating to activation and inhibition of the adrenocortical stress response in man: a review.


Quarterly journal of studies on alcohol.


Immunofluorescent cross-absorption tests for detecting antigenic differences between Bedsonia isolates.


Ego boundaries.

Ego boundaries.


Febrile and local reactions to two highly concentrated trachoma vaccines with and without adjuvant.


An evaluation of the fluorescent antibody technic in the diagnosis of trachoma and inclusion conjunctivitis.


Immunoglobulin levels and TRIC-antibody levels in acute and chronic TRIC infections.


Sialography of the sublingual gland. A modified technique enabling subtraction.


Angiographic diagnosis of tumors arising from the pancreatic islets.


Experimental lymphography in cardiac arrest, electrical ventricular fibrillation and deep hypothermia.


Angiographic diagnosis of rejection and tubular necrosis in human kidney allografts.


Human gastric mucosa: correlation of structure and function.


Intestinal adaptation to small bowel resection.


Development of structure and function in the fetal and newborn stomach.


Digestion, maldigestion, and the gastrointestinal hormones.


The epithelial "membrane" of the small intestine.


Dietary regulation of small intestinal enzyme activity in man.


Celiac disease.

Celiac disease.


Mechanism of the hydrogen peroxide hemolysis  test and its reversal with phenols.


Structural specificity of coenzyme A for phosphotransacetylase.


Albert Cook 1870-1951: Uganda pioneer.

Albert Cook 1870-1951: Uganda pioneer.


Value of prospective tissue typing in kidney transplantation between HL-A identical siblings. The predictability of leucocyte typing in kidney transplantation was assessed by an analysis of 37 kidney transplants from sibling donors. Recipients who were identical for the HL-A antigens with their donors gave highly predictable results. In comparison with those siblings who were incompatible or compatible but not identical their grafts functioned earlier, they required less immunosuppression, and had never had any rejections. They also appeared to have less postoperative morbidity. These results indicate that less immunosuppression than is current in many transplant centres could well be used with benefit in HL-A identical sibling transplants. This could reduce the risk of infection and possibly minimize the adverse effects of steroids on wound healing in these patients.


Immunosuppressive drugs. II. Clinical use of immunosuppression.


Labelled fibrinogen in renal transplantation.


Ultrastructure of a marine psychrophilic Vibrio.


Radiation survival of bacterial spores in neutral and acid ice.


The DNA content of single cells of Micrococcus radiodurans.


Infectious vaginopathies in pregnancy.

Infectious vaginopathies in pregnancy.


Pregnancy, pyelonephritis and prematurity.


Use of antibiotics in obstetric practice.


Chorioamnionitis.

Chorioamnionitis.


Septic abortion and septic shock.

Septic abortion and septic shock. Septic shock in obstetric cases is described, and patient management is discussed.  Cases of septic abortion complicated by septic shock differ from those resulting from bacterial shock.  During the 10 years prior to 1968, Boston City Hospital had a yearly average of 550-600 abortions, and about 26% were septic.  Septic shock developed in 3.8% of patients.  During 1968 and 1969, the number of abortions dropped to 491 and 461, respectively, with 107 septic for 1968 and 73 for 1969; during these years, only 4 cases had septic shock, but these resulted in 2 maternal deaths.  Both of these cases had been mistreated due to inappropriate diagnosis.  The pathophysiology and management of these cases are described.  Most septic abortions complicated by septic shock result from gram-negative organisms which produce endotoxin; in addition, 2 gram-positive organisms, Clostridium welchii and C. perfringens, are frequently responsible for septic shock.  Often, illegal abortion was the cause for septic abortion and shock, but it can also occur with prolonged ruptured membranes and chorioamnionitis in the last trimester.  These patients presented with a variety of clinical symptoms, including septic shock.  They required intensive therapy; about 95% of all septic abortions can be controlled and respond favorably to adequate antibiotic therapy and evacuation of uterine contents.  If the patient fails to respond to this form of therapy, septic shock is frequently a complication.  Under these circumstances, immediate surgical intervention, in the form of total abdominal hysterectomy and bilateral salpingo-oophorectomy, is performed, and the vaginal cuff is left open to allow for adequate drainage.  Without such treatment, mortality rates increase to 60%.  The use of vasopressors if central venous pressure is very low is recommended by this hospital group, Isuprel in particular.  Exchange transfusion is advocated to combat hemolysis.


Utero-ovarian pathology in dysfunctional uterine bleeding.


Surgical management of dysfunctional uterine bleeding.


Differential diagnosis and clinical analysis of dysfunctional uterine bleeding.


Viral hepatitis and the Australia antigen.


Abnormal uterine bleeding at puberty and climacteric.


Anaesthesia in irreversible renal failure.


Vaginal hysterectomy.

Vaginal hysterectomy.


Statistical correlations between total coliform and enterococcus counts in water supply of Tarai region.


Osteopathic hospitals.

Osteopathic hospitals.


Lamellar keratoplasty in the dog: use of the animal laboratory in resident training.


Ultraviolet reactivation in bacteriophage lambda.


Body proportions in children's drawing of a man.


Automatic vacuum systems for paraffin wax impregnation of tissues.


Sacred cows and helpful mice or the transmission and spread of leprosy.


Mycobacterium leprae in the striated muscle of patients with leprosy.


Summary of the results of a search of the skin surface for Mycobacterium leprae.


Activated charcoal. A neglected antidote.


Poisoning from common household products.


Alpha-1-antitrypsin deficiency and disease.


Group A streptococcal infections in newborn nurseries.


Hybrid computer studies of ventilatory distribution and lung volume. I. Normal newborn infants.


Low birth weight and prenatal nutrition: an interpretative review.


Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI).


Investigation into the possible influence of chlorinated amphetamine derivatives on 5-hydroxytryptamine synthesis in man.


A clinical assessment of light and heavy forces in the closure of extraction spaces.


Origins of the word "phrenology".

Origins of the word "phrenology".


The occurrence and spread of ephemeral fever of cattle in Queensland.


Histology and ultrastructure of recurrent glomerulonephritis in human allotransplanted kidneys.


The role of complement in antibody-mediated red-cell destruction.


Report from the Washington office.

Report from the Washington office.


The state boards and dental education.

The state boards and dental education.


Dental Service Plans Insurance Company holds first meeting; Dr. Clarence D. Honig elected president.


Pressure injection of local anesthetics: clinical evaluation of an instrument.


The growth of Salmonella choleraesuis in various enrichment broths.


Further studies on the phage sensitivity and the determination of phytopathogenic Pseudomonas spp.


Pseudomonas viridiflava (Burkholder, 1930; Clara 1934).


A simplified method for quantitative microbiological examination of deep frozen seafoods.


The effect of hibernation on the caecal flora of the thirteen-lined ground squirrel (Citellus tridecemlineatus).


Further studies on long term preservation of marine bacteria.


Aerobic bacterial flora of the Bahama bank.


The evaluation of media used to enumerate sulphate reducing bacteria.


An improved nephelometer culture flask.

An improved nephelometer culture flask.


A colorimetric bioassay method for colicins.


Residual bactericidal action of wool blankets laundered with formaldehyde: a hospital trial.


The assessment of aerosol concentration by means of the Andersen sampler.


The late detection of respiratory syncytial virus in cells of respiratory tract by immunofluorescence. Paired nasopharyngeal secretions were studied in 27 infants infected with respiratory syncytial virus, one taken at onset of illness and one about 7 days later. Both specimens were examined by immunofluorescence and tissue culture for respiratory syncytial virus. In 25 out of 27 (93%) specific fluorescence was still present in cells of the convalescent specimen but was much duller. Virus was difficult to isolate in convalescent specimens; only 8 out of 27 (26%) proved to be positive. Eight single secretions which were taken late in a respiratory illness were also shown to have this altered fluorescence with absence of virus isolation. Preliminary experiments using antihuman globulin suggest that the findings may be due to the attachment of local secretory antibody to the cells causing ;blocking' of staining reaction.


The alpha thalassemia genes.

The alpha thalassemia genes.


Infectious drug resistance among pathogenic enteric bacilli isolated in Thailand.


Carrier rates of intestinal pathogens in restaurant personnel of Bangkok.


Use of loop pyeloplasty in a horseshoe kidney.


Infectious drug resistance in enterobacteria.


The electrocardiogram in the newborn period. I. The normal infant.


Residencies and fellowships.

Residencies and fellowships.


Recipent of the Alpha Omega Fraternity Achievement Medal. Dr. Maynard K. Hine.


Hypersecretion of insulin after the administration of L-leucine to obese children.


The use of autogenous hip marrow in the treatment of juvenile periodontosis. A case report.


The effect of a strontiumhloridetoothpaste on root hypersensitivity in a controlled clinical study.


Incidence of immunoglobulins in fluids of the rabbit genital tracts and the distribution of IgG-globulin in the tissues of the female tract.


Mechanism of action of negamycin in Escherichia coli K12. I. Inhibition of initiation of protein synthesis.


Mechanism of action of negamycin in Escherichia coli K12. II. Miscoding activity in polypeptide synthesis directed by synthetic polynucleotide.


Isolation, purification, and characterization of anticapsin.


Prof. Mikhail Shemyakin, obituary.

Prof. Mikhail Shemyakin, obituary.


Left ventricular volume and cardiac output of the canine heart. Application of a mathematical two compartment model and a new dye dilution technique.


Genetic studies of he ribosoml proteis in Escherichaoli. V. Mapp-ing of erythromycin resistance mutations which lea to alteration of a 50s ribosomal protein component.


Geneti studies of the ribosomal proteins in Escherichi coli. VI. Determination of chromosomal loci for several ribosomal protein components using a hyrid strain between Escherchia coli and Salmonell typhimurium.


Genetic analysis of mutants producing defective beta-galactosidase which can be activated by specific antibodie.


Functional heterogeneity of the 30S ribosomal subunit of E. coli.


Patterns of antibody response of children with infections of the urinary tract.


Light intensity variation. A novel approach to subtraction technique.


In memoriam. John Everett Gary, M.D. 1916-1970.


Some psychiatric aspects of tissue transplanttion.


In memoriam. J. Edward King, M.D. 1897-1970.


Epilepsy and the law in South Africa.

Epilepsy and the law in South Africa.


The caesarean operation.

The caesarean operation.


Cancer chemotherapeutic studies with microcinematographic methods.


A technique of interlacing vascular suture: experimental study in the dog.


The current status of operation for gastric carcinoma in Japan and some suggestions for improvement of operative results.


Festschrift for Dr. Howard C. Taylor.

Festschrift for Dr. Howard C. Taylor.


Family planning comes of age.

Family planning comes of age.


The development of a regional maternity service.


Ovarian cystectomy: a neglected operation.


Evaluation of the effects of isoprenaline and salbutamol aerosols on airways obstruction and pulse rates of children with asthma.


Austin S. Weisberger.

Austin S. Weisberger.


The prepuce used for the repair of a stricture of the bulbous and membranous urethra.


In vivo bactericidal activity of mouse complement against Escherichia coli.


Large doses of steroids in septicaemic shock.


L-dopa in Parkinsonism and the influence of previous thalamotomy. A double-blind cross-over trial over 24 weeks (10 weeks on the active remedy, 4 weeks off treatment, and 10 weeks on placebo) of the effect of L-dopa on idiopathic Parkinsonism (paralysis agitans) has shown no difference in the response obtained in patients who had undergone previous stereotaxic ventrolateral thalamotomy and in those who had not. Of the 34 patients (18 men and 16 women) in the trial 18 had been operated on (nine unilateral, nine bilateral operations) and 16 had not. All patients entering the trial were taking anticholinergic drugs in stable dosage and these were continued throughout. The only factor which seemed to limit the response to treatment was pre-existing hypertension. Of 31 patients who completed the 10-week treatment period, 12 showed marked improvement, 15 moderate improvement, and 4 and mild or negligible change. It seems that previous ventrolateral thalamotomy affords some protection against the development of L-dopa-induced involuntary limb movements on the side contralateral to the operation. As found by others, maximum benefit was seen in bradykinesia and rigidity and related features but a significant reduction in tremor was also noted during treatment. Side effects (nausea, hypotension, and involuntary movements) were common but rarely limited the therapeutic response.


Coronary artery disease. I. Management of the acute episode.


Coronary artery disease. 2. Surgical treatment.


Pedicled homo-skin grafting; an experimental study in animals.


Methods of transplanting nuclei from single cultured cells to unfertilized frogs' eggs.


A recombination function essential to the growth of bacteriophage P22.


Molecular weights of coliphages and coliphage DNA. I. Measurement of the molecular weight of bacteriophage T7 by high-speed equilibrium centrifugation.


Molecular weights of coliphages and coliphage DNA. IV. Molecular weights of DNA from bacteriophages T4, T5 and T7 and the general problem of determination of M.


A supernatant fraction from rat liver capable of replacing G factor in a bacterial cell-free system.


Lactation and lactational amenorrhoea with post-partum IUCD insertions.


Synergism between LH and FSH in the induction of ovulation.


Identification of Actinomyces and related bacteria in dental calculus by the fluorescent antibody technique.


Investigation of copper-manganese-nickel alloys for dental purposes.


An outbreak of type B botulism occurring in Miyazaki Prefecture.


Hemorrhagic necrosis in bone marrow produced by endotoxin and a relation between activities of endotoxin and K-antigen.


Galactorrhea and Parkinson-like syndrome: an adverse effect of alpha-methyldopa.


Stereotactic thrombosis of intracranial aneurysms.


The treatment of hyperlipidemia.

The treatment of hyperlipidemia.


Angiography in the diagnosis of parathyroid carcinoma.


Challenges in rheumatology. A tribute to Nobel Laureate Philip Hench, M.D., F.A.C.P.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 4-1971.


The central lymphoid tissues of rabbits. I. Functional studies in newborn animals.


Complications of anterior cervical disc operation and their treatment.


Sepsis in human renal transplantation.

Sepsis in human renal transplantation.


Kidney transplantation from living donors with bilateral double renal arteries.


Omphalocele--an appraisal of therapeutic approaches.


Loss of fluid and blood to the peritoneal cavity during abdominal surgery.


An inexpensive bedside analogue computer for measuring respiratory work and certain other parameters.


A clinical evaluation of the effct of Ascoxal T on plaque formation and gingivitis.


Some observations on the fine structure of fluorosed dental enamel.


Scanning electron microscopic study of the collagen bundles of the skin in the Ehlers-Danlos syndrome.


Changes in the sedimentation characteristics of DNA due to methylmercuration.


Evidence for the existence of the colicinogenic factors E2 and E3 as supercoiled circular DNA-protein relaxation complexes.


Genetic approaches to determination of enzyme quaternary structure.


The binding of aminoacyl-tRNA and poly U to a soluble factor (S) extracted from ribosomes.


A seven-month double-blind trial of amitriptyline and diazepam in ECT-treated depressed patients.


Estrogen-induced synthesis of histones and a specific nonhistone protein in the uterus.


A comparative double blind trial of pimozide and fluphenazine in chronic schizophrenia.


Perfusion of the isolated pig liver. Functional assessment under control normothermic conditions.


Albert Victor Neale, M.D., F.R.C.P., D.P.H.


On the history and growth of the Bristol Medicl School Library.


Paul Armstrong Christie: 1920-1970.

Paul Armstrong Christie: 1920-1970.


Mortality of perforated duodenal ulcer treated by simple suture.


Kenneth G. Gray 1905-1970.

Kenneth G. Gray 1905-1970.


The concept of crisis.

The concept of crisis.


Dr. Clarence B. Farrar: 1874-1970.

Dr. Clarence B. Farrar: 1874-1970.


Paroven.

Paroven.


In vitro induced disappearance of nucleoli in cells treated with LSD-25.


Newer data on the role of complement system in toxcity of endotoxin.


Antigenic changes during the life cycle of Plasmodium falciparum.


Antitesticular immunity. Role of the basement membrane.


Degree of allogeneic histoincompatibility assayed by the hemolytic plaque technique.


New developments in the therapy of amoebiasis.


Congenital malformations of the central nervous system among Glasgow births 1964-68.


Specificity of blast transformation. II. Studies with erythrocyte antigens.


Gastrointestinal polyposis.

Gastrointestinal polyposis.


Membrane differentiation in the Golgi complex of Micrasterias denticulata Bréb. visualized by freeze-etching.


Some effects of Escherichia coli enterotoxin on net fluid, glucose and electrolyte transfer in calf small intestine.


Properties of recombination-deficient mutants of bacteriophage lambda.


Studies on polynucleotides. XCIV. Transcription of DNA's with repeating nucleotide sequences.


Circular dichroism spectra of oriented and unoriented deoxyribonucleic acid films--a preliminary study.


Circular dichroism of DNA films: reversibility studies.


Glycine transfer RNA of Escherichia coli. I. Structural genes for two glycine tRNA species.


Glycine transfer RNA of Escherichia coli. II. Impaired GGA-recognition in strains containing a genetically altered transfer RNA; reversal by a secondary suppressor mutation.


Feline pancreatic islet cell hyalinosis associated with diabetes mellitus and lowered serum-insulin concentrations.


The vibrios.

The vibrios.


Secondary hyperparathyroidism in chronic renal failure. Effects of renal homotransplantation.


Carl Koller.

Carl Koller.


A typical FTA-ABS test fluorescence in lupus erythematosus.