Kinetics of thermal death of bacteria.

Kinetics of thermal death of bacteria. Experimental observations on thermal injury and death of bacteria in the stationary phase can be explained by assuming that death results from inactivation of (X(L)) of N critical sites. It is assumed: (i) that inactivation of individual sites occurs at random and follows first-order kinetics, (ii) that the critical sites are identical and of equal heat resistance, and (iii) the bacterial population is homogeneous in heat resistance. A method is described for calculating k (the rate constant for inactivation of individual sites), N (sites per cell), and X(L) (the number which must be inactivated to cause death under the experimental conditions used) from experimental data. Theoretical curves calculated by using this model are identical with experimental curves, providing support for the assumptions used. Calculated values of N and X(L) were 130 and 21.7 for Pseudomonas viscosa and 175 and 2.7 for Salmonella anatum. There is considerable uncertainty in the absolute values of N, but they are probably > 100. It is predicted that X(L) will vary depending on the recovery medium used after heating. This theory is consistent with all experimental observations on thermal injury and death of bacteria.


Effects of essential amino acid starvation in Streptococcus faecalis: structural change in the 50S ribosomal subunit. The 50S ribosomal subunits obtained from exponential-phase and valine-limited cultures of Streptococcus faecalis 9790 differed in protein content. Approximately 35% of the valine-limited subunits showed protein losses when analyzed by CsCl density centrifugation after formaldehyde fixation. Results of density gradient analysis and of acrylamide gel electrophoresis localized the protein to a "split" subunit fraction. No differences could be detected in the protein contents of 30S subunits from exponential-phase and valine-limited cultures.


Rate of ribosome production in Bacillus licheniformis. The ribosome content of exponential-phase cells of Bacillus licheniformis was measured at three different growth rates. The average number of ribosomes per cell was about 92,000, 34,400, or 12,500 70S equivalents in balanced cultures growing at 37 C with generation times of 35, 60, and 120 min, respectively. Since the ribosomal particles were shown to be metabolically stable in exponentially growing cells, these figures implicate large differences in the quantity of ribosomes synthesized per unit of time in an individual cell grown under the various conditions. Nevertheless, the time required for the biosynthesis of a single 50S subunit was constant (about 10 min) and independent of the specific growth rate of the cell (within the limits studied). These results show that ribosome production is not regulated by control of the rate of assemblage of individual ribosomes, but rather by control of the number of the ribosomes in manufacture at a time.


Filterability of streptococcal L-forms.

Filterability of streptococcal L-forms. The filterability of the broth-grown stable L-form derived from Streptococcus faecium F24 was tested by filtration under the influence of varying amounts of applied pressure. A decrease in the pore size of the filter resulted in a corresponding decrease in viable count, but no major effect was noted due to the different pressures applied. Serial filtration of a deoxyribonuclease-treated L-form culture in the mid-logarithmic phase of growth resulted in recovery of viable L-forms from the 0.45-mum filtrate but not from the 0.22-mum filtrate. It is possible that disruption of the L-form bodies with release of small viable elements had occurred. Protoplasts, diluted in an osmotic stabilizer, were filtered similarly; L-forms could be grown from the filtrate passing through the filters of 0.45 mum or greater. Filtration of the parent streptococci gave rise to streptococcal colonies from the 1.2-mum filtrate only.


Sterol requirements of T-strain mycoplasmas. T-strain mycoplasmas are very sensitive to digitonin, amphotericin B, and progesterone. This sensitivity and the relatively high content of cholesterol found in the cells indicated a possible requirement of T-strain mycoplasmas for sterols. This suspected requirement was demonstrated directly in a lipid-poor medium and can be met by cholesterol, as well as by beta-sitosterol and to a lesser degree by 7-dehydrocholesterol, cholestanol, stigmasterol, and ergosterol but not by cholesterol laurate or cholestan-3-one. Coprostanol, epicoprostanol, and epicholestanol inhibited cell growth. This inhibition could be partially reversed by increasing the cholesterol concentration in the growth medium. Because of their sterol requirement and their unique requirement for urea, T-strain mycoplasmas might be classified as the third genus in the order Mycoplasmatales.


Prevention of dry socket with local application of tetracycline.


Reynold F. Brown, A.B., M.D. President, Radiological Society of North America.


Officers, Southern Medical Association1970-1971.


Control of acute mountain sickness.

Control of acute mountain sickness.


A double blind controlled study of the pharmacologic effects of nalbuphine (EN-2234A).


Changed differentiation pattern of parental colony-- forming cells in F1 hybrid mice suffering from graft-versus-host disease.


Restoration of thymectomized irradiated mice by frozen and stored thymus grafts.


Discriminant function in clinical trials.


Psychiatric treatment for geriatric patients: "pub" or drug?


Effectiveness of antidepressant drugs: a triple-blind study comparing imipramine, desipramine, and placebo.


Kenneth George Gray, 1905-1970.

Kenneth George Gray, 1905-1970.


Changes in abutment tooth mobility by wearing partial denture.


An experimental investigation for analyzing the influence of impression precedures in clinical technique.


Bacteriological studies on colonised ventriculoatrial shunts.


Differential drug effects of two phenothiazines. (A controlled comparison of thioridazine and trifluoperazine in chronic schizophrenics).


Comparative therapeutic efficacy of spansule form of phenothiazine and phenothiazine tablets.


Cyril Norman Hugh Long.

Cyril Norman Hugh Long.


Effect of carbamazepine (Tegretol) on the electroencephalograph and ward behaviour of patients with chronic epilepsy.


Effects of infused testosterone on mental performances and serum LH.


In memoriam. Capt. P.B. Mukerji, B.Sc., M.B. (Cal.), F.R.C.S. (Edin.), F.F.R. (Lond.), D.M.R.E. (Camb.), F.I.C.S., F.S.M.F.


Robert Gottsegen, D.D.S., New York, New York, President of the American Academy of Periodontology--1971.


Current titles in periodontology.

Current titles in periodontology.


The application of computer techniques to the laboratory diagnosis. Diseases of the liver and biliary system.


Contralateral upper extremity cooling from a specific cold stimulus.


Earl Rankin Crowder, M.D. 1899-1970.

Earl Rankin Crowder, M.D. 1899-1970.


Howard Robert Ripley, M.D. 1907-1970.

Howard Robert Ripley, M.D. 1907-1970.


Carl Bernard Lechner, M.D. 1908-1970.

Carl Bernard Lechner, M.D. 1908-1970.


George P. Daurelle, Jr., M.D. 1923-1970.


Repair of defects in mandible.

Repair of defects in mandible.


The burns unit in Copenhagen. 8. Bacteriology.


Prevalence of the so-called hyperkinetic syndrome in public school children of Vermont.


Psychomotor assessment and rehabilitation of socio-culturally deprived children.


Learning potential: assessing ability to reason in the educable mentally retarded.


Joseph Jules Guillaume Prick.

Joseph Jules Guillaume Prick.


Antilipolytic effect of serum in relation to obesity and fasting (preliminary report).


90Sr-induced osteosarcomas in radiation chimaeras.


Modification of an incompatible graft-versus-host relationship by admixture of grafts with F1 haemopoietic cells.


Ninety-fourth critical bibliography of the History of Science and its cultural influences (to January 1969).


Control of cell growth in bacteria: experiments with thymine starvation. When cells of Escherichia coli THU were starved for thymine, they continued to grow without division for at least two successive volume doublings at their initial rate. Within experimental error this average rate of volume increase, 0.21 mum(3) per hr, was identical with that observed in control cultures during two generations of growth in the presence of thymine. This growth rate was also independent of the age of the cells at the time of starvation. These results are consistent with the hypothesis, proposed earlier, that growth rates are controlled by uptake sites for binding, transport, or accumulation of compounds into the cell, that the number of these sites is constant throughout most of the cell cycle, and that this number doubles near or at cell division.


Pressure sensitivity of streptococcal growth in relation to catabolism. The sensitivity of Streptococcus faecalis growth to hydrostatic pressures ranging up to 550 atm was found to depend on the source of adenosine triphosphate for growth. Barotolerance of cultures growing in a complex medium with ribose as major catabolite appeared to be determined primarily by the pressure sensitivity of ribose-degrading enzymes. Apparent activation volumes for growth were nearly identical to those for lactate production from ribose, and yield coefficients per mole of ribose degraded were relatively independent of pressure. In contrast, cultures with glucose as main catabolite were less sensitive to pressure; glycolysis was less severely restricted under high pressure than was growth, and yield coefficients declined with pressure, especially above 400 atm. Thus, two distinct types of barotolerance could be defined-one dominated by catabolic reactions and one dominated by noncatabolic reactions. The results of experiments with a series of other catabolites further supported the view that catabolic reactions can determine streptococcal barotolerance. We also found that growing, glucose-degrading cultures increased in volume under pressure in the same manner that they do at 1 atm. Thus, it appeared that the bacterium has no alternative means of carrying out glycolysis under pressure without dilatation. Also, the observation that cultures grown under pressure did not contain abnormally large or morphologically deformed cells suggested that pressure did not inhibit cell division more than cell growth.


Requirements of Salmonella typhimurium for recovery from thermal injury. The heating of Salmonella typhimurium 7136 at 48 C for 30 min produces a population of cells that are incompetent at division on Levine Eosin Methylene Blue Agar containing 2.0% NaCl (EMB-NaCl). When these injured cells were placed in fresh citrate salts medium they recovered, and regained their tolerance to the EMB-NaCl medium and grew out. The addition of the selective inhibitors rifamycin, 5-fluorouracil, 2,4-dinitrophenol, chlorotetracycline, chloramphenicol, and 5-methyl-tryptophan to the recovery medium showed that the recovery process was dependent on ribosomal ribonucleic acid (RNA) synthesis, adenosine triphosphate synthesis, and the synthesis of new protein. These results were substantiated by incorporation experiments, which demonstrated that during recovery no deoxyribonucleic acid synthesis, and hence no cell division, occurred. Ribosomal RNA was synthesized during recovery, but its synthesis was not the rate-limiting step. A small but significant amount of protein was also formed during the latter part of the recovery period.


Growth of streptococcal protoplasts and L-colonies on membrane filters. Membrane filters (Millipore Corp.; pore sizes 1.2 to 0.22 mum) were placed on the surface of L-phase growth medium solidified with agar. The filter and the surrounding medium were inoculated with either protoplasts or stable broth-grown L-phase variants obtained from Streptococcus faecium strain F24. The L-phase inoculum gave rise to viable L-colonies on the filters and on the medium, whereas protoplasts gave colony formation only on the medium. However, when the Millipore filters were covered by a layer of solid L-phase medium, 75 mum or greater in depth, before inoculation with protoplasts, colony formation resulted but with atypical morphology. In contrast, inoculation of protoplasts on Nuclepore and Sartorius membrane filters did give rise to L-colonies on the surface and underneath the filters after 2 days of incubation at 37 C. Submicroscopic, viable L-phase elements produced during colony formation were capable of passing through membrane filters with pore channels as small as 0.22 mum; these elements required transfer from underneath the filters to fresh agar medium in order to develop into L-phase colonies. Membrane filters were also placed on the surface of L-phase growth medium solidified with gelatin. Inoculation of the filters and surrounding medium with a lysozyme-prepared protoplast suspension gave rise to streptococci on the surface of the filters and on the medium. However, inoculation with the stable broth-grown L-phase variants gave rise to atypical colonies on the medium and only small patches of abortive growth on the filters.


Induction of hemolysin synthesis by tranformation in Staphylococcus aureus. A nonhemolytic strain of Staphylococcus aureus was transformed with deoxyribonucleic acid extracted from two hemolytic strains of S. aureus. In each case the hemolysin pattern after transformation was identical to that of the donor strain. However, bacteriophage type, serotypes, and other biological properties of the recipient strain remained unaffected.


Determination of the minimal temperature for growth of Escherichia coli. The minimal temperature for growth of Escherichia coli ML30 in glucose minimal medium is between 7.5 and 7.8 C. After transfer to subminimal temperature, growth occurs but is not sustained.


Gellhorn on humility.

Gellhorn on humility.


Ewan Murray-Will.

Ewan Murray-Will.


Clyde Isaac Davis.

Clyde Isaac Davis.


John Alexander Campbell Bamford.

John Alexander Campbell Bamford.


New laboratory.

New laboratory.


Preparing for Stockholm.

Preparing for Stockholm.


Detecting dependence.

Detecting dependence.


Protein polymorphism as a phase of molecular evolution.


Neovitamin B 12 identified.

Neovitamin B 12 identified.


Photo-oxidation of atmospheric SO2.

Photo-oxidation of atmospheric SO2.


How mosquito pupae escape from the surface.


"New" sense organ of primitive gastropods.


Sizing small organisms.

Sizing small organisms.


Dissociation of the circadian drinking pattern from eating.


Movement as a necessary stimulus of Octopus predation.


Abolition of the response of brain stem neurones to iontophoretically applied d-amphetamine by reserpine.


Free radicals in tobacco smoke.

Free radicals in tobacco smoke.


Difference in haemodynamic response to prostaglandins A and E.


Cortical source locations of pattern-related visual evoked potentials recorded from the human scalp.


Possible wind transport of coffee leaf rust across the Atlantic Ocean.


Freezer failure.

Freezer failure.


Better oral health for the elderly.

Better oral health for the elderly.


Presentation of the Henry Spenadel Award to Dr. Seymour J. Kreshover.


Density gradient separation of marrow cells restricted for antibody class. Primitive cells of (C3H x C57BL/10)F(1) mouse bone marrow, participating with thymocytes in immune responses to sheep erythrocytes, are already committed to the immunoglobulin M or immunoglobulin G antibody class. By equilibrium centrifugation in discontinuous gradients of bovine serum albumin, cells responsible for production of IgM immunocytes migrate to the denser regions, whereas those responsible for IgG immunocytes remain in the lower density regions.


The National Health and Medical Research Council. A review of publications relating to matters of radiation health.


Marginal ulceration of the cornea.

Marginal ulceration of the cornea.


In memoriam. Major General Amir Chand, M.B., F.R.C.P. (Edin.), I.M.S. (R).


Richard Alfred O'Brien.

Richard Alfred O'Brien.


Oswald Jacob Ellis.

Oswald Jacob Ellis.


Identification of small amounts of barbiturate sedatives in biological samples by a combination of gas chromatography and mass spectrometry.


A double-blind study of chlordiazepoxide as a preanesthetic agent in cardiac surgery.


Detection of the cancer prone by the automated-computerized metabolic profile.


The achievement of a scientific activist.


William K. Hamilton, M.D.

William K. Hamilton, M.D.


Critical analysis of the microflora of toweling.


A selected public health bibliography with annotations.


Hydrogen sulfide-negative variant of Citrobacter. The characteristics of 25 hydrogen sulfide-negative strains of Citrobacter were studied. The majority of isolates were from the respiratory tract and usually were of indeterminate clinical significance. All strains were highly susceptible to polymyxin B, gentamicin, kanamycin, nalidixic acid, and nitrofurantoin.


Urease color test medium U-9 for the detection and identification of "T" mycoplasms in clinical material. A urease color test fluid medium (U-9) for the detection and identification of T (T-strain) mycoplasmas in clinical material is described which is sensitive and specific for this group of mycoplasmas. The medium was prepared from commercially available components and contained 95% half-strength, tryptic digest broth (pH 5.5), 4% unheated horse serum, 0.05% highest-purity urea, 0.001% sodium phenolsulfonphthalein, and 1,000 units of potassium penicillin G per ml. The final reaction of medium U-9 was pH 6.0. The overall agreement (positive and negative) between urease reactions in U-9 urease color test medium and culture findings in a standard agar primary culture system among 686 clinical specimens was 98.1%. The disagreement consisted of 13 false-positive urease reactions which were recognized visually as false-positive reactions due to other microorganisms. For specimens from the female genitourinary tract, the inclusion of 2.5 mug of amphotericin B (Fungizone) per ml of medium U-9 is recommended for the suppression of growth of Candida species and filamentous fungi.


Hanging magnetic stirrer which minimizes cell disruption. A magnetic stirring bar enclosed in tubing forms a large paddle which produces good mixing at slow rotational speeds. It is suspended above the bottom of the vessel and cannot grind cells or become misaligned.


Microbiological examination of cocoa powder. Total aerobic plate counts of 36 cocoa powders ranged from 100 to 27,000 per g, with 86% having counts of less than 9,300 per g. Bacillus and Micrococcus were the only genera identified.


Prof. Adam Gruca, M. D.

Prof. Adam Gruca, M. D.


Method of measurement of circulatory and respiratory function based on the electronic technique.


Sequential use of Wright's and Ziehl-Neelsen's stains for demonstrating phagocytosis of bacterial spores.


Measurement of left ventricular pressure by a transseptally introduced tipmanometer in man and determination of instantaneous dP-dt and velocity of shortening of the contractile elements by an analog calculating unit.


Algernon Beverly Reese. An appreciation.


Al Reese.

Al Reese.


Algernon Beverly Reese.

Algernon Beverly Reese.


A double-blind evaluation of a stable aqueous solution of chymotrypsin.


Black cornea secondary to topical epinephrine.


The effect of preirradiation of recipient mice on the proliferation of transplanted hemopoietic stem cells.


Studies of marrow transplantation, chemotherapy and cross-circulation in canine lymphosarcoma.


Renal vein thrombosis after transplantation.


A study of the morphology of the denture space.


A photomicrographer of distinction.

A photomicrographer of distinction.


Current bibliography on allergy and applied immunology.


The role of steroids in penetrating keratoplasty.


Anterior sclerectomy, a controlled trial.


Refractive keratoplasty.

Refractive keratoplasty.


Developing ophthalmic treatment in Afghanistan.


The combined operation of cataract and corneal graft.


Problems in the management of oculomycosis.


Corneal and intra-ocular infection due to Fusarium solani.


Surgery in the management of keratomycosis.


Peri-limbal contact lenses.

Peri-limbal contact lenses.


Tranylcypromine-trifluoperazine combination in the treatment of schizophrenia.


Routine diagnosis by computer.

Routine diagnosis by computer.


Eric Berne 1910-1970.

Eric Berne 1910-1970.


Protection of GSR conditioning by dextroamphetamine.


Tissue typing in relation to transplantation.


The incomparable Ernest Kiekenapp.

The incomparable Ernest Kiekenapp.


Recent observations in Jakob-Creutzfeldt disease.


In memoriam Grete Globus, 1901-1970.

In memoriam Grete Globus, 1901-1970.


Experimental spongiform encephalopathy (Creutzfeldt-Jakob disease) in chimpanzees. Electron microscopic studies.


The life force of Grete Globus.

The life force of Grete Globus.


Presentation of award to Webb Haymaker, M.D. by Matthew T. Moore, M.D.


New dean at Boston University: Ephraim Friedman.


Massachusetts Medical Society.

Massachusetts Medical Society.


Index to the Scandinavian Dental Literature.


Essays in honor of Dr. M. Ralph Kaufman: evolving patterns of General Hospital Psychiatry. Foreword.


Bibliography: M. Ralph Kaufman.

Bibliography: M. Ralph Kaufman.


Mo Kaufman: an appreciation.

Mo Kaufman: an appreciation.


M. Ralph Kaufman's contribution to American Psychiatry.


Comparative studies into the isolation of Salmonella from minced meat in five laboratories. Report from a working group.


Reminiscences of forty-five years dealing with the biliary tract.


The repair of defects of the jaws with cancellous bone chips: experience with forty cases.


ICRF expands.

ICRF expands.


Isolation of the cholinergic receptor protein.


Marriage and fertility in academic life.


Uses of artificial insemination.

Uses of artificial insemination.


Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems.


Can a peripheral retinal ganglion cell respond differentially to images in or out of focus?


Isolation of the cholinergic receptor protein of Torpedo electric tissue.


Implications of torsional potential of retinal isomers for visual excitation.


Role of the pericorneal papillary structure in renewal of corneal epithelium.


Conjecture on the visual estimation of relative radial motion.


Duration of in vivo effects of L-asparaginase on experimental metastasis.


Rapid cell culture assay technic for murine leukaemia viruses.


Changes in adrenal enzymes synthesizing catecholamines in attack behaviour evoked by hypothalamic stimulation in the cat.


Control of glycolipid synthesis in a cultured hamster cell line.


Participation of theta-bearing cell in an in vitro assay of transplantation immunity.


Production of lytic plaques of viral origin in Penicillium.


Induction of lactogenesis and abortion by prostaglandin F2-alpha in pregnant rats.


Segregation of univalents on mini spindles.


Bats and fog.

Bats and fog.


DDE reduces medullary bone formation in birds.


Swedish doctoral dissertations in odontology 1917-1970.


Studies on root canal medicaments. 6. Toxic effect of N2 Medical,  Triolin and Oxpara on HeLa cells in vitro.


Biological effect of root canal filling materials. 8. Toxic effect of Rickert's sealer, Triolin and Oxpara on HeLa cells in vitro.


Susceptibility of mink to Clostridium botulinum type C toxin.


Removal of gagging: a response to variable behavior patterns.


Influence of sulfur on in vitro starch digestion by rumen microorganisms.


Physical factors in retention of complete dentures.


The preparation and evaluation of weting dentures for adhesion and retention.


Factors that nfluence retention of removable partial dentures.


Evaluating the size of dentulous stock trays.


Effects of a palatal lift prosthesis upon the speech intelligibility of a dysarthric patient.


Recording maxillomandibular registrations with maximum retention and stability.


Bertram D. Lewin. 1896-1971.

Bertram D. Lewin. 1896-1971.


Computer audiometry in cats.

Computer audiometry in cats.


Robert William West: he was a great man. Some facts of his life not generally known.


Evaluation of a quantal response model with estimated concentrations.


Paul Kimmelstiel: an appreciation.

Paul Kimmelstiel: an appreciation.


Oskar Vogt. 100th anniversary of his birthday.


Infectious Diseases Society of America Squibb Award for general excellence in the field of infectious diseases awarded to Hans J. Müller-Eberhard, M.D. at the Eighth Meeting of the Society in Chicago, Illinois, October 17, 1970.


Prevention of antibiotic resistance in vitro in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by coumadin.


Incidence, species, and significance of Mycoplasma species in the mouth.


Prevention of bacterial overgrowth.

Prevention of bacterial overgrowth.


Pathogenetic events in intestinal chlamydial infections leading to polyarthritis in calves.


Tetanolysin: in-vivo effects in animals.


Evaluation of phagocytic activity by ingestion of labeled bacteria.


Diagnostic and technical considerations for successful cornea grafting.


Paediatric aspects of transplantations.

Paediatric aspects of transplantations.


Digital computer analysis of respiratory patterns in the neonatal period.


Physical signs in the early diagnosis of thrombophlebitis.


Computers in the identification of cardiac arrhythmias.


Favourable effect of intravenous diazepam on muscular spasms in the lower extremities following iothalamate (Conray) radiculography.


Comparison of the effects of carbon, nitrogen and iron limitation on the growth and on the RNA and DNA content of Mycobacterium smegmatis.


Treatment of primary dysmenorrhea with a combined type oral contraceptive--a double blind study.


Growth of male-specific bacteriophage in Pasteurella harboring F-genotes derived from Escherichia coli. When either the F' lac or the F'Cm plasmid was transferred from Escherichia coli into Pasteurella pseudotuberculosis, the P. pseudotuberculosis (F') strains isolated formed plaques with both ribonucleic acid (RNA)-containing and deoxyribonucleic acid-containing male-specific phages. In contrast, strains of P. pestis harboring E. coli (F') plasmids did not form plaques with male-specific phages, although such strains permitted limited multiplication of phage MS2. The adsorption and burst size of MS2 were approximately the same in both species of Pasteurella, but the per cent of adsorbed MS2 that produced infective centers was much lower in P. pestis than it was in P. pseudotuberculosis. By use of a sib-selection technique of P. pestis (F') cells, we isolated a single clone that could form MS2 plaques. (32)P-labeled MS2 adsorbed equally to and its RNA penetrated equally into both the typical MS2-nonpermissive P. pestis cells and the MS2-permissive P. pestis cells. No host modification occurred after growth of MS2 in Pasteurella. Our data suggest that typical strains of P. pestis inhibit the intracellular development of phage MS2.


Frederick John Clark.

Frederick John Clark.


Stanley Augustine McDonnell.

Stanley Augustine McDonnell.


Lloyd Edgar Buley.

Lloyd Edgar Buley.


Botulism in the United States, 1899-1969.


Use of triethylenethiophosphoramide as an adjuvant to the surgical treatment of gastric and colorectal carcinoma: ten-year follow-up.


Antihypertensive effect of clonidine. Its use alone and in combination with hydrochlorothiazide and guanethidine in the treatment of hypertension.


Experimental design in headache treatment.


Dan Gordon, M.D.

Dan Gordon, M.D.


Pollution in its place.

Pollution in its place.


Royal Commission provides framework for study.


Human breast cancer virus?

Human breast cancer virus?


The search continues.

The search continues.


Search for a human breast cancer virus.

Search for a human breast cancer virus.


Colour and brightness preferences in monkeys.


Decomposition and the determination of fluorine in biological materials.


Neutralization of murine mammary tumour virus by sera of women with breast cancer.


Localizing 3H-GABA in nerve terminals of rat cerebral cortex by electron microscopic autoradiography.


Preparation of highly radioactive bovine anti-mouse lymphocyte antibody.


In vitro assay of cell mediated immunity in human cancer: definition of leukocyte migration inhibitory factor.


Private and public antigens of the mouse H-2 system.


Lentinan, a new immuno-accelerator of cell-mediated responses.


Does virus infection have evolutionary significance?


Hangover effect of hypnotics in man.

Hangover effect of hypnotics in man.


Owen Vivian Davies.

Owen Vivian Davies.


Antigenic conversion by phage P27. I. Mapping of the prophage attachment site on the Salmonella chromosome.


A clinical survey of removable partial dentures after 2 years usage.


The effects of four hypnotic drugs and placebo on normal subjects' sleeping and dreaming at home.


The use of the air turbine in impacted third molar surgery.


Large versus small, single versus multiple computers.


High-density medical data management by computer.


Visual display terminals in a Hospital Information System (HIS).


Computers and doctors: use and consequences.


Prosthesis theory goes into private practice.


The in vitro antibacterial effectiveness of antibiotic-detergent combinations.


Lingual fill-in on lower impression.

Lingual fill-in on lower impression.


On the structure of self-esteem: comments on Ziller's formulation.


A surgical prosthesis retained by magnets: a case report.


Grommets and glue ears: a clinical trial.


Double-blind trial of a combination of chlordiazepoxide, ephedrine and theophylline (brontrium) in bronchospasm.


Gordon David Ley.

Gordon David Ley.


Computers in the service of medicine.

Computers in the service of medicine.


Comparative evaluation of tests in the diagnosis of pulmonary hydatid cysts.


Clinical and physiological evaluation of mucolytic agents nebulized with soproterenol: 10 per cent N-acetylcysteine verus 10 per cent 2-mercaptoethane sulphonate.


Controlled therapeutic trials.

Controlled therapeutic trials.


Immunosuppressive drugs in rheumatoid arthritis.


Clinical trial of malaria prophylaxis in tropical splenomegaly syndrome. A controlled, randomized, double-blind trial of malaria prophylaxis in tropical splenomegaly syndrome showed a significant reduction in spleen size and an improvement of anaemia and symptoms in patients treated with antimalarials compared with control subjects receiving placebo. This study confirms the observations from West Africa and provides further indirect evidence for a malarial aetiology of tropical splenomegaly syndrome.


A doctor's humanity: an obsessive response to a childhood experience.


Maine Medical Association. Official roster.


Directory of otolaryngologic societies.

Directory of otolaryngologic societies.


Accuracy of diagnosis of bacterial diarrheal disease by clinical features.


Mortimer Spiegelman's contributions to public health statistics.


Comparison of oral penicillin G and clindamycin as prophylactic antibiotics in oral surgery.


Conditions for production of 3-ketomaltose from Agrobacterium tumefaciens. Up to 39% yields of 3-ketomaltose were achieved in 18 to 22 hr when Agrobacterium tumefaciens NRRL B-36 was cultured at 25 to 28 C in a simple medium containing 4.0 to 8.0% maltose, 0.09% urea, 0.5% CaCO(3), 0.6% KH(2)PO(4), and 0.025% MgSO(4).7H(2)O. For maximum production of 3-ketomaltose the culture had to be maintained approximately at pH 7.0.


Method for studying particle size and infective potential of infectious bovine rhinotracheitis virus aerosols. A technique is described for estimating the number of potential respiratory infectious loci of aerosolized infectious bovine rhinotracheitis virus.


Biochemical and serological characteristics of a Yersinia enterocolitica isolate. Yersinia enterocolitica was isolated from human mesenteric lymph nodes. Its morphological characteristics and biochemical and serological reactions are described.


Differential identification of Mycobacterium kansasii and Mycobacterium marinum. This report deals with the differential diagnosis between Mycobacterium marinum and M. kansasii. We found that the two species could be differentiated by using six main tests, namely, the nitrate reduction test, the arylsulfatase test, the ability to grow in the presence of 10.0 mug of amithiazone per ml, the ability to grow in the presence of 5.0 mug of kanamycin per ml, the temperature-ratio test, and the rate of growth on solid medium. In contrast to M. kansasii, considerable variation was observed among strains of M. marinum. However, the evidence obtained was not considered sufficient to justify the conclusion that more than one species was represented among the strains identified as M. marinum.


The development of heterologous grafts of the cardiac area (labeled with thymidine-3H) to the caudal area of the chick blastoderm.


Some in vitro observations in cultures of human fetal cerebral cortical tissue.


Morton Hamburger (1907-1970).

Morton Hamburger (1907-1970).


Computer-aided prognosis. II. Development of a prognostic algorithm.


Distribution of intravenously inoculated staphylococci in heart valves and viscera. A study in dogs with and without aortic insufficiency.


Resorption of bone collagen by multinucleated cells.


Use of computers for the diagnosis of diabetes in old age.


Gram-negative bacteria of medical importance. Monograph of simplified tables for their identification.


Obligatory role of the delta 5-bond of cholesterol for steroid formation by adrenal preparations.


Changes in liver and spleen scans of patients during treatment with two hypolipidemic drugs.


Malcolm Maclean Rose Hall, M.D. 1903-1970.


Robert A. Bearor, M.D. 1922-1970.

Robert A. Bearor, M.D. 1922-1970.


Members, State Medical Society of Wisconsin.


Kuru-plaques in a case of Creutzfeldt-Jakob disease.


Haloforms: sweet taste of smell?

Haloforms: sweet taste of smell?


Occupational dermatitis in five European dermatological departments.


Elisabeth Geleerd Loewenstein.

Elisabeth Geleerd Loewenstein.


Hemopoietic environment necessary for an early stage in differentiation of antibody-forming cells: effect of cortisol.


An apparent discrepancy between the number of colony forming units transplanted and survival of busulphan lethally treated rats.


Obituary. Hans Hoff.

Obituary. Hans Hoff.


Paul Leland Kirk.

Paul Leland Kirk.


1970 Nurse of the Year Award.

1970 Nurse of the Year Award.


Bone marrow transplantation.

Bone marrow transplantation. The goals in bone marrow transplantation are its application to the treatment of diseases arising in the blood-forming tissues of man. Techniques for procuring and grafting marrow are of the needle-and-syringe type and are based on the normal physiological processes in which stem cells circulate through blood and other fluids of the mammalian organism. Destruction of bone marrow by irradiation, chemicals, or unknown agencies provides the immediate experimental system for demonstrating the therapeutic value of marrow transplants. Genetic diseases characterized by abnormal marrow function are also modifiable by grafts of blood-forming tissues. Studies with identical twins are critical experiments for showing the clinical value of grafts, even though the transplanted cells cannot be identified by the usual marker techniques. Among the best results seen with marrow grafting is the presumed cure of certain rare hereditary immune-deficiency disorders of children. A major problem in bone marrow transplantation-one that delays its wider clinical application-is the immune reaction from cells growing out of the foreign transplant which attack the host (the graft-versus-host reaction). Attempts to use a graft-versus-host response to eliminate tumor cells is a part of the marrow research program. The history of the processes that led to some of the achieved goals in marrow grafting shows the usual multicentric origin of an idea. Certain individuals play critical roles in developing the idea. Finally, a body of knowledge is accumulated that opens up or limits prospects for the future. In bone marrow transplantati on, future achievements will depend in part on the progress that is made in the areas of cell separation, bone marrow banking, and tissue culture.


American Academy of Optometry. Geographical directory of members United States, Canada, Mexico and overseas.


Experience with information retrieval.

Experience with information retrieval.


In memoriam: Shirley Alma Johnson Greenwalt.


Instrumentation for computerized heart catheterization.


Effects of freeze-drying and sporulation on microbial variation.


Slopes of the carotid pulse wave in normal subjects, aortic valvular diseases, and hypertrophic subaortic stenosis.


Treating anxiety and depression in the elderly. A double blind crossover evaluation of two widely used tranquilizers.


Immunologic investigations of meningococcal disease. I. Group-specific Neisseria meningitidis antigens present in the serum of patients with fulminant meningococcemia.


Modification of bone marrow induced GVH disease with heterologous antisera to gamma globulin or whole serum.


Antiemetic efficacy of benzquinamide. Controlled study.


Panel sanctions amphetamines for hyperkinetic children.


Atraumatic adjustment of copper bands in fixed prosthodontics.


Gingival retraction for crown and bridgework.


Membership list.

Membership list.


Montgomery-Bucks Dental Society membership--1970.


Techniques to stabilize complete dentures.


Air as the sole coolant in operative dentistry.


Tooth supported complete dentures.

Tooth supported complete dentures.


Corrective surgery.

Corrective surgery.


Fixed-prosthesis impressions: a rubber base reline ttechnic.


The intraoral approach to genioplasty.

The intraoral approach to genioplasty.


The posterior palatal seal area in complete denture construction.


Labial bar.

Labial bar.


The geriatric patient and prosthodontic problems.


The SR-Ivotray method. Intraoral registration of the centric relation by the closed mouth impression technique.


Rebuilding the enoodontic tooth in fixed prosthodontics.


Washington State Dental Association membership roster.


Membranous glomerulonephritis with nephrotic syndrome in transplanted kidney.


Early pathogenesis of colitis in neonatal pigs monocontaminated with Escherichia coli. Fine structural changes in the circulatory compartments of the lamina propria and submucosa.


Early pathogenesis of colitis in neonatal pigs monocontaminated with Escherichia coli. Fine structural changes in the colonic epithelium.


Antacids and posttransplant hypophosphatemia.


The heterogeneity of an acid-soluble fraction of casein, a possible subunit of kappa-casein.


The role of sulfhydryl groups in the activity of type A botulinum toxin.


Lipids of bovine enamel and dentin and human bone.


History of Canadian surgery. George Edgeworth Fenwick (1825-1894).


The mechanism of pepsin secretion in the isolated perfused canine stomach.


Clinical experience with the use of a single-layer intestinal anastomosis.


Skin transplantation in horses.

Skin transplantation in horses.


Pediatric urinary tract infections: a review.


Abraham Jacobi, M.D.--1830-1919--pioneer pediatrician.


Spongy degeneration of the central nervous system in infancy.


Bacteriological study of jejunal fluid in idiopathic tropical malabsorption syndrome.


Hospital dietetics in Indonesia.

Hospital dietetics in Indonesia.


The eye chart and Dr. Snellen.

The eye chart and Dr. Snellen.


The pathologic significance of occult blood in feces.


A skin punch technique for equine skin grafting.


Procurement, fixation, and submission of tissue specimens for microscopic examination.


"Hemodynamic studies before and after one hour of total cardio-pulmonary bypass in the dog by the dye-dilution method".


Lens development. V. Histological analysis of the mechanism of lens reconstitution from implants of lens epithelium.


James Syme (1799-1870), a great surgeon who promoted proctology.


A sex difference in immunologic responsiveness.


Burrell O. Raulston 1886-1970.

Burrell O. Raulston 1886-1970.


Richard Hale Young 1906-1970.

Richard Hale Young 1906-1970.


Quarterly Journal of studies on alcohol.


The American Semmelweis.

The American Semmelweis.


Thomas Jefferson and medicine.

Thomas Jefferson and medicine.


Alcoholic cardiomyopathy. Concept of the disease and its treatment.


Fasting--a review with emphasis on the electrolytes.


Successful treatment of Pneumocystis carinii and Nocardia asteroides in a renal transplant patient.


Escherichia coli endotoxemia in the conscious pony.


Comparison of histologic features of ovarian and uterine tissues with vaginal smears of the bitch.


Acquired toxoplasmosis: infection versus diseases.


Identification of "T" mycoplasmas in primary agar cultures by means of a direct test for urease.


Known clinical mycobacterial organisms.

Known clinical mycobacterial organisms.


Further evidence to support the role of infectious agets and-or immunologic sequelae in the causality of the chronic and degenerative disease of man.


Thiamine uptake in Escherichia coli. 3. Regulation of thiamine uptake in Escherichia coli.


Role of potassium in the regulation of polysome content and protein synthesis in Escherichia coli.


Isolation and characterization of a temperature-sensitive mutant of Escherichia coli with a lesion in the acylation of lysophosphatidic acid.


The amino acid sequences of two large glycopeptides derived from the carbohydrate-carrying region of alpha 1-acid glycoprotein.


NH2-terminal methionine in nascent peptides from Neurospora crassa.


The release of chromatin template restrictions by natural polyribonucleotides.


Inhibition of binding of transfer ribonucleic acid to ribosomes by ribosomal proteins.


Interaction of proflavine and 9-aminoacridine with DNA at temperatures below and above the melting temperature.


Anterior cruciate ligament repair in cattle.


Current status of canine urolithiasis.

Current status of canine urolithiasis.


Treatment of Brodie's abscess by means of bone autograft.


Renal allograft in a dog poisoned with ethylene glycol.


Clinico-pathologic conference.

Clinico-pathologic conference.


Validity of the histochemical phosphorylase and uridine diphosphate-glycogen transglucosylase methods.


Effects of bacterial endotoxin and crowding on pine voles and white mice.


Changes in pulmonary extravascular water volume following mitral valve replacement.


Genetics of immunity deficiency syndromes.


The applicability of Bernoulli's law in the process of enlargement and rupture of aortic aneurysms.


Ventilation and perfusion after transplantation of the lung. Studies with intravenous xenon-133.


Progress in rabies research.

Progress in rabies research.


The filter paper disc technique for the detection of antibodies against hog cholera virus.


The laboratory diagnosis of bovine virus diarrhea by fluorescent antibody.


Government investment in health care.

Government investment in health care.


Trematode infections and cestode infections.


The effect of diethyl pyrocarbonate on the biological activity of messenger RNA and transfer RNA.


Circulatory responses to hemorrhage in dogs with cardiac autotransplantation.


Mechanical ventilation of the newborn.

Mechanical ventilation of the newborn.


Blood-brain transfer of glucose and other molecules measured by rapid indicator dilution.


Management of schizophrenia in the Veterans Administration.


Mechanical ventilation of newborn infants. 3. Historical comments and development of a scoring system for selection of infants.


Mechanical ventilation of newborn infants. IV. Technique of controlled intermittent positive-pressure ventilation.


Some selected psychosomatic problems of current interest.


Mechanical ventilation of newborn infants. V. Five years' experience.


Constant positive-pressure breathing and cardiorespiratory function.


Sedative--hypnotics.

Sedative--hypnotics.


Plaque production by hog cholera virus.

Plaque production by hog cholera virus.


Lowering of intraocular tension. Effects of isosorbide and glycerin.


Hamster tumors induced by type I avian adenovirus (CELO). I. Histopathology and neoantigen of virus-induced and transplanted tumors.


Glaucoma.

Glaucoma.


Further observations on the enlargement of synaptic vesicles in degenerating optic nerve terminals of the avian tectum.


Structural identification and distribution of synaptic profiles in the octopus brain using the zinc iodide-osmium method.


Fine structural aspects of the synaptic organization of the spinal trigeminal nucleus (pars interpolaris) of the cat.


No effect of folic acid supplement on CSF folate and serum vitamin B12 in patients on anticonvulsants.


Electron microscopic study of hereditary corneal edema.


Immunological factors in nonspecific stimulation of host resistance to syngeneic tumors. A review.


Painful non-union of a fractre of the fifth metatarsal. A case report.


The use of a bacterial L-amino acid decarboxylase for the control of the degree of racemization of amino acid mixtures obtained from protein hydrolysates.


Degradation of Escherichia coli B deoxyribonucleic acid after infection with deoxyribonucleic acid-defective amber mutants of bacteriophage T7. The degradation of bacterial deoxyribonucleic acid (DNA) was studied after infection of Escherichia coli B with DNA-negative amber mutants of bacteriophage T7. Degradation occurred in three stages. (i) Release of the DNA from a rapidly sedimenting cellular structure occurred between 5 and 6 min after infection. (ii) The DNA was cleaved endonucleolytically to fragments having a molecular weight of about 2 x 10(6) between 6 and 10 min after infection. (iii) These fragments of DNA were reduced to acid-soluble products between 7.5 and 15 min after infection. Stage 1 did not occur in the absence of the gene 1 product (ribonucleic acid polymerase sigma factor), stage 2 did not occur in the absence of the gene 3 product (phage T7-induced endonuclease), and stage 3 did not occur in the absence of the gene 6 product.


T-even bacteriophage-tolerant mutants of Escherichia coli B. I. Isolation and preliminary characterization. A general procedure is described for isolation of T-even phage-tolerant mutants of Escherichia coli. Two such mutants of E. coli B have been examined in some detail. These mutants adsorb T-even phages but are unable to release viable progeny. Under certain conditions, viability of the cells is completely unaffected by phage infection in one mutant, and there is but a slight decrease in colony-forming ability in the other. Phage deoxyribonucleic acid (DNA) is injected into these cells, as shown by the formation of phage-specific enzymes, but it is not degraded to acid-soluble material. Some phage DNA replication occurs in both strains. The mutants are both more resistant to ultraviolet light than is the parent strain.


No right to die?

No right to die?


Nixon buys plan for attk on cancer.

Nixon buys plan for attk on cancer.


Lack of knowledge.

Lack of knowledge.


Continuous requirement for host P10 protein during bacteriophage T4 infection. The Escherichia coli 30S ribosomal protein P10, the product of the str gene, known to be involved only in the initiation of protein syntehsis, is required for all bacteriophage T4 protein synthesis.


Lambda mutants which persist as plasmids. Lambda phages mutated in gene N do not kill sensitive host bacteria, but persist as plasmids. Plasmids are formed by genomes containing cI(+), and also by sus, ts, or c mutants of cI. Bacteria infected with two or more phage particles give rise to clones in which most of the bacteria are carriers. The introduced lambda genomes replicate more than once per bacterial division until there are 10 to 20 lambda plasmids per host genome. In bacteria containing both F and lambda plasmids, both replicate independently, and elimination by growth in acridine orange is also independent. Carriers of lambda Nsus plasmids are not immune, and there is complementation between the plasmids and superinfecting lambda mutants.


Inhibition of host protein synthesis during infection of Escherichia coli by bacteriophage T4. II. Induction of host messenger ribonucleic acid and its exclusion from polysomes. Two gene clusters on the Escherichia coli chromosome were induced at early times after T4 infection when >99% of the cells were infected: the lactose (lac) operon and prophage lambda. Their messenger ribonucleic acid (mRNA) was detected by hybridization to phi80 dlac deoxyribonucleic acid (DNA) and lambdaDNA, respectively. Synthesis of host mRNA could be initiated during the first few minutes after T4 infection, although no beta-galactosidase activity could be detected. Hybridization analyses of selected fractions from sucrose gradients revealed that most of this lac mRNA induced at very early times of T4 infection was not associated with ribosomes. In contrast, virtually all lac mRNA in uninfected bacteria was associated with polysomes. This exclusion affected all host mRNA; about 70% of E. coli(3)H-mRNA, labeled from 2 to 3 min after T4 infection, was excluded from polysomes. Infection even reduced the yield of beta-galactosidase from lac mRNA induced before infection. Gradients from rifampicin-inhibited cells showed the normal growth of lac mRNA polysomes; in contrast, T4 infection prevented growth of the preinduced lac polysomes. It is concluded that T4 infection interferes within seconds with the reassociation of ribosomes to host mRNA.


Origin of satellite DNA.

Origin of satellite DNA.


Advice to advisers.

Advice to advisers.


Clean air act.

Clean air act.


Enterosecretory proteins.

Enterosecretory proteins.


Early DNA replication patterns of the normal sex chromosomes and presumptive X-autosome translocation in cattle (Bos taurus L).


Capacitation of hamster spermatozoa by beta-glucuronidase.


Absence of adrenergic nerves in the human placenta.


The lap-frogging slug.

The lap-frogging slug.


Effects of LSD on receptive fields of single cells in the lateral geniculate nucleus of the cat.


Extensions to the study of science students' divergent thinking ability.


Dr C.N.H. Long.

Dr C.N.H. Long.


Putting drugs in their place.

Putting drugs in their place.


Scientific inofrmation by computer.

Scientific inofrmation by computer.


Ball lightning as an optical illusion.

Ball lightning as an optical illusion.


Meiotic DNA synthesis.

Meiotic DNA synthesis.


Nuclear transplantation in Drosophila melanogaster.


Pre-emption in immunity.

Pre-emption in immunity.


Two types of phototactic behaviour in anuran amphibians.


Biochemistry: IJB and EJB.

Biochemistry: IJB and EJB.


Histidine metabolism.

Histidine metabolism.


Story of the pits.

Story of the pits.


Rehabilitation medicine: definition and origin. Twentieth John Stanley Coulter Memorial Lecture.


Special award. Frank H. Krusen, M.D.

Special award. Frank H. Krusen, M.D.


1970 Gold Key Award. Edward W. Lowman, M.D.


1970 Gold Key Award. Ernest W. Johnson, M.D.


Nucleoside deaminase and adenosine deaminase activities in regenerating mouse liver.


Infrared studies of DNA's, their constituents and analogues. VI. Denaturation of DNA's from microorganisms.


Inactivation of the T7 coliphage by the diepoxybutane stereoisomers.


The replication of bacteriophage phi X174 DNA in vitro. Temperature effects on repair synthesis and displacement synthesis.


Structure of serine tRNA from Escherichia coli. I. Purification of serine tRNA's with different codon responses.


Quantitative analysis of preservatives drug preparations by microbiological assay. The stability of a preservative selected for incorporation into a drug preparation can only be determined by suitable tests applied at regular intervals, preferably over long periods. Chemical tests are available for a number of preservatives and some of them appear to be adequate but difficulties have occurred from time to time and studies were undertaken to develop microbiological tests. Chemical methods are usually more precise than biological assays but do not always measure the antimicrobial activity of the preservative as accurately. It is always possible that a preservative may break down, losing some of its effectiveness even though the chemical determinant upon which the test is based remains intact.Two assay methods were studied. One, a plate-diffusion procedure, was found suitable for assaying formol and preservatives containing mercury. Preservatives such as phenol, benzethonium chloride and others do not diffuse in an agar plate and a tube-plate bacterial count procedure was developed for this group. Procedures for both tests are described and some examples given.


The microstructure of colonies of the Connaught BCG strain. It has previously been shown that there is a certain correlation between the biological properties of BCG strains-properties on which their immunogenicity and allergenicity depend-and the macroscopic appearance of the growth of these colonies on solid and liquid media. To investigate this phenomenon in greater detail, the author examined the microstructure of colonies of the Connaught BCG strain grown on both solid and liquid media. Colonies were fixed in agar, embedded in paraffin, sectioned and stained by the Ziehl-Neelsen technique.A striking finding was the alternation of acid-fast and non-acid-fast zones in colonies grown on bovine-serum agar or Ogawa egg medium; the strata nearest the surface of the solid media were usually more acid-fast than were the deeper strata. Colonies grown in Sula's liquid medium, on the other hand, showed no such stratification and were equally acid-fast at all points. These differences may be the result of genetic factors or of the different nutritional conditions provided by solid and liquid media.


Serum dopamine-beta-hydroxylase activity.


Anencephaly.

Anencephaly.


Testing new drugs for safety. Problems, challenges, responsibilities.


A South Carolina physician, 1693-1697.

A South Carolina physician, 1693-1697.


Streptococci in children's respiratory infections: diagnosis and treatment. Clinical characteristics of pharyngitis related to group A streptococci and practical utility of nose and throat bacteriology in office practice.


Some implications of the circulation theory for disease theory and treatment in the seventeenth century.


Pharaoh Akhenaton of ancient Egypt: controversies among Egyptologists and physicians regarding his postulated illness.


Nicolas Chervin's yellow fever survey, 1820-1822.


Etienne Pariset: a medical career in government under the Restoration.


Etienne Joseph Jacquemin, discoverer of 'Chadwick's sign'.


Charles Donald O'Malley 1907-1970.

Charles Donald O'Malley 1907-1970.


C.D. O'Malley's Vesalius: an appreciation.


Dr. George Sinclaire's patent, 1725.

Dr. George Sinclaire's patent, 1725.


Three generations of Tulane doctors establish enviable reputation in profession.


Ivor John Paull.

Ivor John Paull.


William Sydney Charles Copeman.

William Sydney Charles Copeman.


A history and physical on Napoleon Bonaparte.


A short review on dermatophytoses of animals in Romania.


Simultaneous measurement of quantitative data in neuroanatomy.


A primer for writing medical data base for the clinical decision support system.


Epidemiological investigations or oral Candida albicans.


Computing devices of the second and third generations.


A computer program for the determination of cerebral blood flow using the Kr-85 or Xe-133 intra-arterial injection method.


Treatment of hospitalized alcoholics with doxepin and diazepam. A controlled study.


First woman fellow of The College of Physicians of Philadelphia: memoir of Catharine Macfarlane. 1877-1969.


Ancient Korean medicine.

Ancient Korean medicine.


Robert Meredith Page. February 5, 1919-May 17, 1968. Remembrances of a Mycological Sharpshooter, Trusted Mentor, Blithe Spirit.


S. Weir Mitchell: investigations and insights into neurasthenia and hysteria.


Reminiscences of public health in Pennsylvania: the Cleft Palate Program.


William Gibson, M.D., anatomist, as seen by a student in 1823.


Memoir of Moses Behrend. 1877-1969.

Memoir of Moses Behrend. 1877-1969.


Memoir of Edward L. Bortz. 1896-1970.

Memoir of Edward L. Bortz. 1896-1970.


Memoir of Harry D. Evans, Jr. 1911-1969.


Memoir of C. Calvin Fox. 1892-1969.

Memoir of C. Calvin Fox. 1892-1969.


Memoir of Alvin W. Howland. 1902-1969.

Memoir of Alvin W. Howland. 1902-1969.


Memoir of Henry Bittinger Kobler. 1878-1970.


Classification, diagnosis and treatment of subphrenic abscesses.


Memoir of Albert A. Lucine. 1895-1969.

Memoir of Albert A. Lucine. 1895-1969.


Memoir of Louis Merves. 1912-1969.

Memoir of Louis Merves. 1912-1969.


Memoir of Joseph Walter Post. 1887-1969.


Passive serologic transfer of immunity to skin grafts in allogeneic and isogeneic mice.


Memoir of Manuel Sall. 1906-1969.

Memoir of Manuel Sall. 1906-1969.


Memoir of Albert Carl Sautter. 1878-1966.


Memoir of Creighton H. Turner. 1882-1968.


Recent studies on the active principles of Jamaican medicinal plants.


Study of bacterial populations in natural environments by use of submerged electron microscope grids.


On methane-oxidizing bacteria in fresh waters. II. A method for the estimation and statistical evaluation of the metabolic turnover of gases by methane-oxidizing bacteria.


Motile marine bacteria. IV. Ionic relationships of marine and terrestrial bacteria.


The harp seal, Pagophilus groenlandicus (Erxleben, 1777). 13. The gross and microscopic structure of the auditory meatus.


Studies of physiologically active arthropod secretions. V. Histological studies of the defence mechanism of Narceus annularis (Raf.) (Diplopoda: Spirobolida).


Demonstration of the common precursor for production of IgM and IgG antibodies.


The adenosine triphosphate pool and the adenyl cyclase activity in Escherichia coli strains with different UV sensitivity.


Decomposition of vanillin by soil microorganisms.


The relationship between thymine-less death and growth rate in Escherichia coli 15 TAU.


Some biophysical aspects of E-B virus adsorption to the surfaces of three types of mammalian cells.


Effect of combination treatment with cyclophosphamide and isogeneic or allogeneic spleen and bone marrow cells in leukemic (L1210) mice.


The development of chick-embryo-lethal-orphan (CELO) virus T and V antigens in lytically infected chick kidney cells.


Adhesion of human erythrocytes to glass: the nature of the interaction and the effect of serum and plasma.


Catheterization of the mesenteric and portal vein in calves.


Variation in portal blood flow measured by dye-dilution in young calves.


Chromosome chimerism and skin grafts in bovine twins and a shift in the sex ratio of their progeny.


The doctor's dilemma: whether or not to recommend continuous renal dialysis or renal homotransplantation for the child with end-stage renal disease.


Ataxia telangiectasia with granulocytopenia.


A suggested role of the lysosomal membrane as a part of the defence mechanism against tuberculous infection.


Analysis of host-originated lipids associated with "in vivo grown tubercle bacilli".


Demonstration of mycolic acid and phthiocerol dimycocerosate in "in vivo grown tubercle bacilli".


History of the Medical Society of the District of Columbia. Chapter 8. Pressures for change.


Escherichia coli meningitis--treatment with gentamicin sulfate.


A preliminary study of the effects of cyclandelate.


John Ellis Gillespie.

John Ellis Gillespie.


Frederick Bryant Uther.

Frederick Bryant Uther.


Dr Francis Campbell of Tarban Creek Asylum.


The Medi-Cal cutbacks of 1967 revisited.


Organic-mercury food poisoning.

Organic-mercury food poisoning.


A cell is not an island entire of itself.


Venous thrombosis.

Venous thrombosis.


Adrenaline, digitalis and beta-adrenergic blockade during anaesthesia.


Home health services and health insurance.


Structure of the hinge region of the mu heavy chain of human IgM immunoglobulins. The amino acid sequence around the central disulfide bridge linking the mu heavy chains of the human immunoglobulin M monomer is unlike that in immunoglobulin G. This hinge area contains one of the five oligosaccharides of the mu chain, is low in proline, and is the site of tryptic cleavage to yield Fabmicro and Fcmicro fragments.


Sequential hemodynamic patterns in various causes of shock.


Transsexualism and surgical procedures.

Transsexualism and surgical procedures.


Studies in aerobic cellulose-decomposing bacteria. I. Evaluation of media for enumeration.


Excerpts from the history of postoperative fluid therapy.


Suture technic for the friable mitral annulus.


Gas-liquid chromatography of some irritants at various concentrations.


In vitro DNA synthesis in the presence of antibody to homogeneous E. coli DNA polymerase.


Evidence for peptide nature of LH and FSH-releasing hormones.


Origin of DNA and protein in lambda DNA infected disrupted cell preparations.


Cytolysomes in Tetrahymena pyriformis Gl. I. Synchronized cells dividing in inorganic salt medium.


Canadian Society of Laboratory Technologists. New members and certified members registered in 1970.


Skin, heredity, and cancer.

Skin, heredity, and cancer.


The origin, basis and nature of medical malpractice liability.


The influence of growth temperature on the thermal resistance of E. coli.


Influence of ionic conditions on cell differentiation and morphogenesis of the cellular slime molds.


The growth in vitro of new processes from vestibular neurons isolated from adult and young rabbits.


Synchronization of human cell lines with colcemid.


Microscopy of living epithelial cells upon the intact ocular lens in culture.


Trypanosoma rhodesiense and T. brucei: absence of antibodies in chicken embryos.


Acanthamoeba castellanii: specificity of immobilization test.


Fats in adult nutrition.

Fats in adult nutrition.


Genetic and ecological factors in human growth.


Cytochemical and biochemical observations on the digestive tracts of digenetic trematodes. IV. A radioautographic and histochemical study of iron absorption in Haematoloechus medioplexus.


Immune nephritis in dogs.

Immune nephritis in dogs.


Production of amylase by Thermoascus aurantiacus Miehe.


Antibody response to E. coli urinary tract infection.


Histological study of Gryllodes sigillatus (Walk.).


Grand slam or of the life and achievements of Harry Eagle, scientist. Recorded 65 years after his birth by his friend and admirer.


Harry Eagle.

Harry Eagle.


The action of Mendelian genes in human diploid cell strains.


Construction of a finger plate with delayed contiguous skin-bone pedicle graft for loss of four digits. A case report.


Antinuclear antibodies: their significance in scleroderma.


Classification and pathogenesis of scleroderma.


Sociometry as an adjunct to nurse teaching.


Leopold Kirschner.

Leopold Kirschner.


The treatment of migraine with BC 105 (pizotifen): a double blind trial.


Oral sulphonylureas in the management of diabetes.


The effect of diuretic (Centyl, Leo) on the oedema of the hand following surgical treatment of Dupuytren's contracture.


Time-lapse studies of mitosis and sex chromatin in human fibroblasts.


On the use of ultrasonic diagnosis in ophthalmology and medicine.


Direct preparation of chromosomes from mouse peripheral blood.


A self-learning computer program for cell recognition.


The early diagnosis of uterine cancer by smears.


Odorico Viana and his contribution to diagnostic cytology.


Septal bone graft for correction of saddle nose.


Rudolf Ludwig Carl Virchow (1821 to 1902).


Usefulness of benzoylated naphthoylated DEAE-cellulose to distinguish and fractionate double-stranded DNA bearing different extents of single-stranded regions.


Control of late messenger RNA synthesis during lambda phage development.


Cleavage of Escherichia coli tyrosine tRNA-2 in the S-region and its effects on the structure and function of the reconstituted molecules.


Inhibition of nucleic acid and protein synthesis in Escherichia coli by oxidized polyamines and acrolein.


The effect of guanosine 5'-triphosphate analogues on protein synthesis.


Increased resistance of DNA replication to ultraviolet light damage in amino acid-starved bacteria.


Lipid changes in Salmonella typhimurium on infection with bacteriophage P22.


Lipid metabolism in the parasitic and free-living spirochetes Treponema pallidum (Reiter) and Treponema zuelzerae.


Studies on the oral apparatus of Tetrahymena pyriformis Gl.


Early history of the Steno-Fallot tetralogy.


Combined surgical and radiation injury. V. The effect of bone marrow transplantation.


Adjuvant activity of ricin as measured by Jerne's plaque technique.


Uptake of bacterial H3-DNA into fish embryos.


A probable effect of diabetes mellitus on incorporation of amino acids into proteins catalyzed by isolated rat liver nuclei.


Review article. Current concepts of calcification.


Chronic idiopathic hyperphosphatasia associated with pseudoxanthoma elasticum.


Origin of the Golgi apparatus in embryonic cells of the grasshopper.


Submaxillary gland recovery from obstruction. I. Overall changes and electron microscopic alterations of granular duct cells.


The behavior of HeLa-S3 cells under the influence of supranormal temperatures.


The treatment of arrhythmias following acute myocardial infarction.


Treatment of uncomplicated peptic ulcer disease.


Insulin-independent diabetes mellitus.

Insulin-independent diabetes mellitus.


Hypertensive emergencies.

Hypertensive emergencies.


Diuretic drug therapy of edema.

Diuretic drug therapy of edema.


Therapeutic considerations in selected forms of acute and chronic liver disease.


Management of the obese patient.

Management of the obese patient.


Treatment of arrhythmias: basic considerations.


A comprehensive regimen for osteoarthritis.


Airway obstruction.

Airway obstruction.


Pharmacologic considerations in the treatment of anxiety and depression in medical practice.


Drug interactions.

Drug interactions.


Disorders of potassium metabolism.

Disorders of potassium metabolism.


Nutritional management of kidney disorders.


Cytology of the anterior chamber fluid in eyes with corneal xenografts.


Substrate specificity of Escherichia coli peptidyl-transferase.


Reaction of puromycin with chemically prepared peptidyl transfer RNA.


Studies on extrachromosomal DNA elements. Replication of the colicinogenic factor Col E1 in two temperature sensitive mutants of Escherichia coli defective in DNA replication.


Level of methionyl-tRNA synthetase in merodiploids of Escherichia coli K12.


Miscoding by Escherichia coli tRNAs for methionine, cysteine and valine in the synthesis of rabbit globin.


The influence of gold on the kinetics of plaque-forming cells.


Effect of antigen dose on stimulation of anti-hapten plaque forming cells of different affinities.


The immune response of normal, irradiated and thymectomized mice to fowl immunoglobulin G as detected by a hemolytic plaque technique.


Passive sensitization of tissue cells. IV. Guinea-pig antibodies cytophilic for basophils and Kurloff cells.


Nephrotoxicity of antibodies to species-specific antigens.


The 25-g intravenous glucose tolerance test: a critical appraisal.


Arthur C. Giese.

Arthur C. Giese.


Absence of repair replication following ultraviolet irradiation of an excision-deficient mutant of Escherichia coli.


Presentation of Elizabeth Blackwell Medal to Rosa Lee Nemir, M.D.


The closure of surface defects with free skin grafts and with pedicle flaps.


The analgetic action of dimethyl sulfoxide (DMSO) ointment in arthrosis. A double blind study.


The properties of nickel-chromium casting alloys containing boron and silicon.


Some data about Australia antigen (HAA) in Great Britain.


The forebrain of the prairie dog (Cynomys ludovicianus) in stereotaxic coordinates.


Virus studies in hepatitis.

Virus studies in hepatitis.


Ambroise Paré on dentistry.

Ambroise Paré on dentistry.


Australia antigen in chronic hemodialysis.


Effect of stereotaxic operations on lung function and acid-base equilibrium in Parkinson patients.


The role of the cerebellar nuclei in spasticity.


Akinesis following stereotactic surgery for Parkinsonism. The use of L-dopa.


Stereotactic treatment of different kinds of spasmodic torticollis.


Stereotaxic intracerebral instillation of dopa.


Visual responses to subcortical stimulation in the visual and limbic systems.


Recording of somato-sensory evoked potentials during mesencephalotomy for intractable pain.


The long-term results after the stereotactic implantation of yttrium 90 into the pituitary gland as a treatment for Cushing-syndrome.


Calculation of position of electrode point during penetration in human brain.


The variability of the position and somatotopic relation of the nucleus ventro-oralis thalami.


A method for visualizing the entire third ventricle.


The use of a shadowgraph for stereotactic surgery.


Presentation of a stereotaxic frame designed for the simultaneous introduction of two or more stereotaxic tools.


Intracranial measurements for stereotactic surgery.


Tissue impedance along probe trajectories in thalamotomy.


EEG depth leads during stereotaxic brain surgery. A report on 117 cases (5 target points, effects of 13 different drugs).


Threshold stimulation of a human thalamic-subthalamic target area before and after electrocoagulation.


Olfactory hallucinations evoked from stimulation of human thalamus.


Stereotaxic ablation of the irritable focus in temporal lobe epilepsy.


Thalamotomy in hyperactive and aggressive behavior.


Stereotactic treatment for the alleviation of intractable pain. Reassessements and limitations.


Subthalamotomy in Parkinson's disease.

Subthalamotomy in Parkinson's disease.


Bilateral, three negative, cortical evoked potentials after unilateral stimulation of the thalamic VL nucleus in man.


Stereotaxic amygdalotomy in behavior disorders.


The combined thalamo-subthalamotomy.

The combined thalamo-subthalamotomy.


Pathophysiology of tremor at rest derived from the correlation of anatomical and clinical data.


The relationship of denture complaints and level of neuroticism.


Recent advances in the use of topical fluoride preparations.


An unusual hybrid prosthesis.

An unusual hybrid prosthesis.


Suppression of memory by passive immunization late in the primary response. The acquisition of a capacity to respond well to sheep erythrocytes in the presence of anti-SRBC antibody was taken as an indication of the presence of immunological memory. By the use of passive immunization, both the primary IgG plaque-forming cell response and the establishment of memory were abolished, despite occurrence of a full peak IgM PFC response. Evidence for regarding the aquisition of memory and the IgM PFC and IgG PFC responses as three separate processes was presented. Antibody on day 3 of the response to 1.5 x 10(8) SRBC abolished formation of memory; this effect was less if passive immunization was further delayed and absent by day 10.


In vitro organization of dissociated rat cardiac cells into beating three-dimensional structures. When isolated beating ventricular heart cells from newborn rats were grown in tissue culture on untreated polystyrene surfaces, they showed a striking tendency to grow focally in three dimensions from the single layer cell sheets which were formed early in growth. During this process, they frequently formed miniature spherical heart-like masses, which continued to beat and grow in size. These often were somewhat lobulated in appearance, and grew up to 2 mm in diameter. Histological sections of such structures sometimes revealed evidence of appreciable orientation of the cells to each other, in fiber-like units. Electron microscope sections of such mini-hearts showed structures resembling intercalated discs between myocardial cells. The precise factors which induced the cardiac cells to apparently organize into these heart-like structures are not presently known.


Skin homografts: tolerogenic versus immunogenic influences in mice. In strain combinations involving multiple non-H-2 disparities, neonatal skin grafts may survive significantly longer than adult grafts of similar genotype on normal adult hosts, and repeatedly outlive grafts of adult origin on immunosuppressed recipients. Moreover, newborn grafts of long-standing may render their hosts unresponsive to adult skin grafts from the same donor strain. With some H-2-compatible strain combinations in which homozygous neonatal grafts are rejected, F(1) hybrid (heterozygous) grafts of similar age not only may survive indefinitely, but also may induce tolerance of subsequent adult parental strain homografts. These tolerogenic and gene dosage effects, although much weaker, can likewise be revealed with H-2-incompatible neonatal skin grafts.


Phil H. Jones, MD: in appreciation.

Phil H. Jones, MD: in appreciation.


Books as clinical tools.

Books as clinical tools.


Alfred John Craig.

Alfred John Craig.


Preservation of young canine liver by perfusion.


Attempts at localization of urinary tract infection.


The effect of homologous rabbit antiserum on the growth of Leishmania tarentolae--a fine structure study.


Historic hospitals. An early municipal hospital, Bruges.


Robert W. Hull, 1924-1970.

Robert W. Hull, 1924-1970.


Effects of actinomycin D on the erythropoietic restoring capacity of mouse bone marrow cells.


Psychopharmacology.

Psychopharmacology.


Ingestion of particulate antigens by the intestine of the fowl (Gallus domesticus) stimulated by Escherichia coli.


The intestinal microflora of turkeys.

The intestinal microflora of turkeys.


Therapeutic effect of Linco-Spectin on airsacculitis in chickens.


Fast and slow components of S-100 protein fraction: regional distribution in bovine central nervous system.


Changes of neurones dimensions as a possible morphological correlate of their increased functional activity.


Determinations of nerve and glial cell volumes in histological sections.


An in vitro study on migration activity of spleen cells of allografted and antithymocytic serum treated animals.


Psychiatry and abortion.

Psychiatry and abortion.


Clinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037).


Evaluation of a humoral factor in liver regeneration utilizing liver transplants.


Effect of electrical stimulation of the preoptic area on plasma LH concentrations in proestrous rats.


Effects of hypothalamic and preoptic electrochemical stimulation on gonadotropin and prolactin release in proestrous rats.


Effects of starvation on hypothalamic FSH-RF and pituitary FSH in male rats.


Glucose metabolism of isolated pancreatic islets: difference between fetal, newborn and adult rats.


Effect of potassium on neuron survival in cultures of dissociated human nervous tissue.


Distribution of various protein fractions in central and peripheral myelin.


A re-evaluation of cinnarizine with geriatric in-patients.


Identification of direct hemolytic plaques as IgM or IgG plaques by hapten inhibition. Kinetics of anti-hapten plaque forming cell response in the rabbit.


Antibody-producing cells in bone marrow and other lymphoid tissues during the primary immune response in mice.


Studies on actively allergised cells. 3. Suppression of the allergic response with specific antibody and the effect of this treatment on plaque and rosette-forming cells.


New evidence for an anti-estrogenic action of clomiphene citrate in women.


Growth hormone and cortisol responses to insulin-induced hypoglycemia in thyrotoxicosis.


Enhanced susceptibility to iodide myxedema in patients with Hashimoto's disease.


Fructose induced growth hormone release.


Acute undifferentiated human diarrhea in the tropics. I. Alterations in intestinal micrflora. The microflora of the small and large intestine was determined in 17 adults with acute undifferentiated diarrhea in Calcutta, India. On the basis of bacteriologic findings, the patients could be divided into two groups: those with a predominant flora of Escherichia coli (eight patients) and those with a mixed coliform flora (nine patients). In the former group, E. coli were distributed throughout the small and large bowel. Broth filtrates of these isolates contained an enterotoxin which caused fluid accumulation in the rabbit intestinal loop model. Toxigenic E. coli were cleared rapidly from the small bowel during the acute period; some patients only had the "hot" strains in their fecal effluent. During convalescence, the serotypes of E. coli changed and the new strains did not elaborate enterotoxin. Only one of the eight patients had a serotype previously associated with diarrhea. Acute undifferentiated diarrhea in the remaining cases was apparently caused by untypable E. coli or by typable strains not generally considered pathogenic. Small bowel and fecal cultures from the mixed flora group revealed a heterogeneous mixture of Gram-negative enteric bacilli and a distinct pattern could not be discerned. Further study will be needed to elucidate the cause of diarrhea in these cases.


Studies of opsonic activity in univalent 6.5S rabbit antibacterial antibody.


Passive serologic transfer of allograft immunity in immunologically suppressed mice. II. Effect of graft exposure to immune serum in primary hosts.


The effect of administration of human growth hormone on the plasma growth hormone, cortisol, glucose, and free fatty acid response to insulin: evidence for growth hormone autoregulation in man. The effect of administration of human growth hormone (HGH) (3 mg every 6 hr for 6 days) on the endogenous GH response to insulin-induced hypoglycemia at 8, 12, 24, and 48 hr posttreatment was studied in 11 healthy male adults. Free fatty acid, cortisol, and glucose responses pre- and posttreatment with HGH were evaluated concurrently. Control subjects received saline injections to evaluate relationship of GH responses to the periodicity of insulin tolerance tests. The data were compared for each subject pre- and posttreatment with HGH as well as by comparison of the results of the saline-treated group with those of the HGH-treated group. The mean maximal GH concentration in response to insulin-induced hypoglycemia for all the subjects (n = 16) was 31.1 +/-3.6 ng/ml (+/-SEM) on day 1 of the control period and 23.4 +/-3.1 (SEM) on day 2, not statistically significant.A significant decrease in the maximal peak GH response (n = 8) after insulin-induced hypoglycemia was observed at 8 and 12 hr after HGH administration was terminated with mean peak values for GH of 4.6 +/-1.3 ng/ml and 10.4 +/-1.9 ng/ml, respectively (P < 0.01). A progressive return to control values was noted between 12 and 24 hr. The GH responsiveness of the saline-treated group (n = 5) was unchanged from that observed during the control period. The fasting glucose values were unchanged in the GH-treated group from those of the control period or of the saline-treated controls. Insulin resistance was apparent at 8 hr posttreatment with HGH. No differences in FFA response after insulin-induced hypoglycemia were observed in GH-treated or saline-treated subjects. The rise in plasma cortisol after insulin-induced hypoglycemia was comparable in the GH-treated and saline-treated group. Diurnal variation in plasma cortisol was maintained during the period of GH suppression. These observations support the concept that GH can modulate its secretion by means of an auto-feedback mechanism.


A study of mixed cell interactions between sensitized and allogeneic mouse spleen cells in vitro using the hemolytic plaque assay.


Acute undifferentiated human diarrhea in the tropics. II. Alterations in intestinal fluid and electrolyte movements. The nature and magnitude of fluid and electrolyte loss into the small intestine were defined by the marker perfusion technique in patients with acute undifferentiated diarrhea (AUD) in the tropics. The patients were divided into two groups according to their small bowel bacteriologic findings, namely those with a predominant Escherichia coli flora and those with a mixed flora. 11 normal subjects served as controls. Net jejunal fluid secretion occurred into the lumen in four of seven patients with E. coli flora and three of seven with a mixed flora. The magnitude of secretion in the jejunum was greater in the E. coli flora patients than in those with a mixed flora. Four E. coli patients and one mixed flora patient had net fluid secretion in the ileum, although the magnitude of secretion in this area was less than in the jejunum. Intestinal fluid had higher bicarbonate concentration in the ileum than in the jejunum but was isotonic in both regions. It resembled in composition fluid from the same region of intestine in normal individuals. Recovery of normal fluid and electrolyte absorptive function was usually complete in both jejunum and ileum by 6-8 days after onset of the disease. Increase in unidirectional flux rates for H(3)O and (24)Na occurred in acute E. coli flora diarrhea and returned to normal levels in recovery: increase in J(beta) (plasma to lumen flux) primarily accounted for the increase in fluid loss. Intestinal biopsy revealed no alterations in villous architecture.A relationship between small bowel fluid production and the presence of toxigenic strains of E. coli within the small bowel has been found for E. coli flora patients. In many respects this disease resembles acute cholera. The mixed flora group represents a less defined entity which requires further study.


Use of leukocyte chemotaxis in vitro to assay mediators generated by immune reactions. I. Quantitation of mononuclear and polymorphonuclear leukocyte chemotaxis with polycarbonate (nuclepore) filters.


Detection of antibody-like structures on cell surfaces with chemically modified bacteriophages.


Reappearance and relative importance of immunocompetent cells in the thymus, spleen and lymph nodes following lethal x-irradiation and bone marrow reconstitution in mice.


Genetic control of the immune response in mice. 3. An association between H-2 type and reaction to H-Y.


Lipomas of the spinal cord and cauda equina.


Dr. Theodor Reik: a life devoted to Freud and psychoanalysis.


Cardiothoracic surgery.

Cardiothoracic surgery.


Plastic and reconstructive surgery including burns.


Transplantation.

Transplantation.


Urology.

Urology.


A new operative technique for pilonidal sinus.


Technical considerations in posterior gastropexy.


The transplantation of teeth.

The transplantation of teeth.


Durability of prosthetic heart valves.

Durability of prosthetic heart valves.


Antiarrhythmic drugs.

Antiarrhythmic drugs.


Thomas Shadwell: his exitus revis'd.

Thomas Shadwell: his exitus revis'd.


Depression kinetics of ornithine transcarbamylase in Escherichia coli. A mathematical model for the derepression of ornithine transcarbamylase (OTC) in Escherichia coli strain W was derived from a set of 14 assumptions concerning the arginine regulon. The model assumes that active repressor for the arginine regulon is unstable and is only formed when the level of arginyl-tRNA is in excess of the level necessary to maintain protein synthesis for a given cell doubling time. The presence of active repressor was assumed to inhibit the synthesis of messenger RNA coding for the synthesis of the enzymes of the arginine biosynthetic pathway. Numerical estimates of the model's parameters were made and, by simulation on a digital computer, the model was shown to fit kinetic data for derepression of OTC in E. coli W cells in minimal medium growing in flask culture with a doubling time of 60 min and growing in a chemostat with a generation time of 460 min for an assumed OTC-specific mRNA half-life (t(1/2)) of 9 min. The model was also shown to predict the increase in the size of bursts of OTC synthesis elicited by addition of arginine to cultures of derepressing E. coli cells with the increase in the delay time before arginine addition. Approximate analytical solutions to the model were obtained for the early phase of derepression and for repression of OTC. These were used to derive graphical methods for determining t(1/2) from repression and derepression transient changes in the OTC level.


International comparisons in the study of the functional psychoses.


Michigan Dental Hygienists' Association membership directory.


Respiratory dieease in childhood.

Respiratory dieease in childhood.


Success and failure in human virus disease. IV. Immunization.


Recent advances in surgery of ongenital heart disease. In the cyanotic group palliative procedures for transposition of the great arteries are frequently life-saving in infancy, and the definitive operations such as the atrial baffle, and the Rastelli procedure for those with ventricular septal defect and pulmonic stenosis, are now firmly established. In tetralogy of Fallot shunting procedures continue to be employed in infancy and early childhood, and the complete repair is usually done after the age of five. Corrective operations for total anomalous venous return may have to be staged, and the results are more satisfactory in older children. The various forms of endocardial cushion defects can usually be recognized accurately preoperatively, and where the normal anatomical relationships can be restored, excellent results obtained. Brilliant operative success can now be had in some forms of truncus arteriosus and double outlet right ventricle. It is quite common to find congenital heart disease in adults, frequently after many years of having been treated as rheumatic heart disease. The operative risk in this group is less than 10 percent, and in most instances such patients are restored to their normal physiological age after operation.


Morphinandienone alkaloids.

Morphinandienone alkaloids.


Prenatal diagnosis of lipid storage diseases.


Accuracy in clinical chemistry.

Accuracy in clinical chemistry.


Silvaforming.

Silvaforming.


A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results.


Studies on islet cell regeneration, hyperplasia and intrainsular cellular interrelations in long lasting streptozotocin diabetes in rats.


Trichinella spiralis: enzymes reducing and oxidizing cytochrome c in rat muscles.


The blood and transfusion fluids in shock.


Hepatic changes associated with shock.

Hepatic changes associated with shock.


Calcification of connective tissue.

Calcification of connective tissue.


Former dental school dean honored.

Former dental school dean honored.


G. Coleman promoted to Rear Admiral.

G. Coleman promoted to Rear Admiral.


Essential trace metals in man: selenium.


Penicillin-sensitive enzymatic reactions in bacterial cell wall synthesis.


Title X1X Program.

Title X1X Program.


Prevention of rabies in man.

Prevention of rabies in man.


Gastrin-the natural history of a peptide hormone.


Optimal method for bone cutting in clinical practice.


Michigan state medical society directory.


Bowel sound quantitation to evaluate drugs on gastrointestinalmmotor activity.


Spina bifida; an ever increasing problem.


Studies on the physiological availability and metabolism of sulfonamides. I. Sulfadiazine.


A bunch of grapes: the discovery of staphylococci.


Studies on the physiological availability and metabolism of sulfonamides. II. Sulfisoxazole.


Stereological studies on several ducts and vessels by injection method of acrylic resin. XXV. On the occipital artery in some mammals.


American Academy of Implant Dentistry. Directory of Membership, 1970.


Fenfluramine, a new anorexigenic agent.

Fenfluramine, a new anorexigenic agent.


Spina bifida and the paraplegic service.


Tracheal stenosis following tracheostomy.


Lincomycin administered by intravenous infusion to normal volunteers. I. Tolerance.


Some observations on the lethal effects of near-ultraviolet light on Escherichia coli, compared with the lethal effects of far-ultraviolet light.


Hormonal control of mammalian spermatogenesis.


Roentgen examination of the larynx and hypopharynx.


South African medical and dental council: Suid-Afrikaanse geneeskundige en tandheelkundige raad. Opening address.


Editorial. Escalation of Medicaid spending.


Directory of dentists of Loma Linda University School of Dentistry.


Dr. A. C. De Vet.

Dr. A. C. De Vet.


Symposium on stereotaxic operations in extrapyramidal disturbances organized by the Netherlands Society of Neurosurgeons held in Groningen (The Netherlands), 15 November, 1969. Introduction.


The endothelium in clear and progressively edematous corneal transplants.


Dr. Elisha North and the first eye infirmary in the United States.


Chronic pancreatitis.

Chronic pancreatitis.


Escherichia coli with resistance factors in vegetarians, babies, and nonvegetarians. The prevalence of Escherichia coli carrying resistance factors (R factors) was examined in meat-consuming individuals and in those not consuming meat (vegetarians and babies below the age of 6 months). Assuming that the transport of resistant E. coli from animals through meat and meat products to the human consumer is most important, with regard to the incidence of resistant E. coli in man, we expected a significant difference in the proportions of people with resistant E. coli between the two groups. However, the percentage with resistant E. coli was larger in the group of vegetarians and babies than in the group of meat-eating individuals.


Computer-aided prognosis. I. Organization and coding of data.


Fatty acids and the release of glucagon from isolated guinea-pig islets of Langerhans incubated in vitro.


The simulation, fitting, and testing of a stochastic cellular proliferation model.


The structure of enterochelin and related 2,3-dihydroxy-N-benzoylserine conjugates from Escherichia coli.


A timely correspondence: 1945 (Ray Lyman Wilbur and Gov. Earl Warren).


The 1970 annual meeting of the American Rheumatism Association.


A study of 52 cases of adenocarcinoma of the bladder.


The results and complications of scrotal-flap urethroplasty for stricture.


Parasitological review. Nippostrongylus brasiliensis: a review of immunity and host-parasite relationship in the rat.


Action of anesthetics on somatic evoked activities.


The control of samonellae affecting swine and man.


Biological responses to antibacterial feed additives in diets of meat producing animals.


Addendum to the Biographical Directory of Members of the International Association for Dental Research.


Sensory processes and age effects in normal adults.


Chelsea pensioners. Original watercolor by Isaac Robert Cruikshank (1789-1856).


Current dental care plans and the Indiana dentist.


Casting force in several casting methods. I. Casting pressure produced by gaseous pressure cating apparatus and speed of revolution of centrifugal casting machine.


Antibacterial factors in the sipunculid worms Golfingia gouldii and Dendrostomum pyroides.


Casting force in several casting methods. 2. Comparison of casting time in several casting methods.


Experimental study on the alveolar ridge reconstruction with bone transplantation.


Tooth supported lower complete denture.

Tooth supported lower complete denture.


Clinicopathologic conference. Jakob-Crettzfeldt disease.


The curse of Saint Thomas.

The curse of Saint Thomas.


The interaction of an I-like R factor and transfer-deficient mutants of Flac in E. coli K 12.


Detrick left hanging.

Detrick left hanging.


How to avoid sloppy dentures?

How to avoid sloppy dentures?


Advances in surgery.

Advances in surgery.


Personal reminiscences of Bertram W. Sippy and the "Sippy service".


From medical topography to epidemiology.


Abnormal regional myocardial performance in coronary artery disease.


Noninvasive techniques in acute myocardial infarction.


The value and limitations of coronary care monitoring.


The pathologic basis of sudden death.

The pathologic basis of sudden death.


Mechanisms of sudden death and their implications for prevention and management.


Improved method for construction of cast chromium-cobalt skeleton prostheses.


Restoration of abraded crowns and abutments.


In vitro recognition of diethylstilbestrol by anti-azobenzoyl estradiol IgG.


Marihuana in man: three years later.

Marihuana in man: three years later. The past 3 years of renewed research on the effects of marihuana in man has added little not previously known about the clinical syndromes produced by the drug. The major advance has been a quantification of dose in relation to clinical phenomena, and a beginning of an understanding of the drug's metabolism. The crucial clinical experiments in regard to the social questions about marihuana, such as the possible deleterious effects from chronic use, cannot be answered by laboratory experiments. These must be settled by close observations made on those who experiment on themselves. It should be possible, within a relatively short time, to determine whether marihuana has any medical utility, but the future would appear to be no more promising than the past in this regard. The mechanisms by which marihuana alters mental functions are not likely to be answered in man, nor even answered soon by animal studies. As marihuana may be unique among drugs in that more experimentation has been accomplished in man than in animals, it may be necessary to look to additional animal studies to provide leads for pertinent future studies in man.


Ophthalmological Society of the United Kingdom. List of members of the society.


The Harry G. Armstrong Lecture. Decompression sickness: advances and interpretations.


Acute stimulation of cortisol metabolism by pentobarbital in man.


The sacral part of the sympathetic trunk in human fetuses and newborns.


A review of the nutrition of Japanese quail.


The interaction of nitrogen dioxide with monomolecular films of cholesterol, dihydrocholesterol, and cholesteryl acetate.


Temperature responses of mice to Escherichia coli endotoxin.


The two varieties of lymphoid tissue "reticulosarcomas", histiocytic and histioblastic types. On the basis of histological sections and cytological smears in 110 cases, the "reticulosarcoma" (exclusive of Ewing's sarcoma and reticulosarcomas of bone marrow) were divided into two varieties: histiocytic types and histioblastic types.The correlation between the histological and cytological evaluation was excellent in each case; only those tumours classified as histiocytic presented a continuous and abundant network of reticulin.The histioblastic type predominated in the male sex. The difference in the clinical expressions of the two varieties is not statistically significant, except as to the frequency of cutaneous lesions: 27.7% in the histiocytic type and 2.6% in the histioblastic type.While the duration of their evolution is not different, only the histioblastic type is transformed into leukaemia, which is of the "monoblastic" type: this transformation was observed in 17.5% of cases, while it was never observed in histiocytic type.


Coxsackie virus B4 pericarditis in mice.


Bladder function in infants and children.


The cultivation and identification of anaerobic bacteria in the Veterinary Diagnostic Laboratory.


Chlorine gas poisoning in farm livestock: case report and review.


Methods for detecting antibody.

Methods for detecting antibody.


The theory of supervision in psychoanalytic education.


Crystalline pyruvate oxidase from Escherichia coli. 3. Phospholipid as an allosteric effector for the enzyme.


Enzymatic modification of proteins. V. Protein acceptor specificity in the arginine-transfer reaction.


Nucleotide activation of cauliflower alpha-ketoglutarate dehydrogenase.


Subunit structure of aspartate transcarbamylase from Escherichia coli.


Patterns of ribonucleic acid synthesis in T5-infected Escherichia coli. IV. Examination of the role of deoxyribonucleic acid replication.


Patterns of ribonucleic acid synthesis in T5-infected Escherichia coli. V. Formation of stable, discrete, degradation products during turnover of phage-specific ribonucleic acid.


Polymerization of deoxyribonucleoside diphosphates with an enzyme from an Escherichia coli mutant lacking deoxyribonucleic acid polymerase activity.


The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action.


The nephrotic syndrome and Plasmodium malariae in the Yemen Arab Republic.


Coliforms and fecal coliforms in an oyster--growing area.


Malaria in a heroin user.

Malaria in a heroin user.


Whooping cough is first described as a disease sui generis by Baillou in 1640.


Multiple organ transplantation and the creation of surgical siblings.


On a peculiar form of infantile convulsions (hypsarrhythmia) as described in his own infant son by Dr. W.J. West in 1841.


The treatment of rickets, as suggested by Boerhaave and Glisson and interpreted by Dr. John Theobald of Londin in 1764.


The book of accidents. Excerpt IV: Burns.


The development of the sensory epithelium of the cristae ampullares in the rabbit.


The Bühner method for control of chronic vaginal prolapse in the cow. (Review and evaluation).


Further field studies on the fluorescent antibody test in the diagnosis of ovine abortion due to toxoplasmosis.


Studies on the immunity of the calf to colibacillosis. I. The influence of colostral whey and immunoglobulin fractions on experimental colisepticaemia.


New York State computerized proficiency testing program in exfoliative cytology development.


Fellows and members of The International Academy of Cytology as of January 1, 1971.


The communicating branch of the facial nerve to the lesser petrosal nerve in human fetuses and newborns.


Ultraviolet light-induced purine modified DNA.


A new intermediate in naphthoquinone and menaquinone biosynthesis.


The intestinal microflora of turkeys: comparison of apparently healthy and bluecomb-infected turkey poults.


A direct complement-fixation test for detection of mycoplasma antibodies in chicken serum.


Reversible inhibition of RNA phage replication and macromolecular synthesis by levorphanol.


A suggested reclassification of avian mycoplasma serotypes.


Transfer RNA methylase inhibitors in neoplastic and normal rat tissue.


Pathogenesis and histopathology of airsacculitis in turkeys produced by experimental inoculation of day-old poults with Mycoplasma meleagridis.


Lesions of Marek's disease in a Great Horned owl.


Salmonellosis in the horse.

Salmonellosis in the horse.


Adaptation and propagation of avian infectious bronchitis virus in embryonic turkey kidney cell cultures.


Prosthetics in dental practice.

Prosthetics in dental practice.