Effectiveness of live or killed plague vaccines in man. While the safety of the available live plague vaccine EV 76 (Paris) continues to be the subject of further study, the USP formol-killed, virulent Pasteurella pestis (Yersinia pestis) suspension capable of protecting 60% of non-human primates, particularly Hanuman langurs (Presbytis entellus), warrants further clinical tests and field trials. Inoculated in a dosage of 2x10(9) killed plague bacilli (1 ml), followed by a booster of 400 million organisms (0.2 ml) in 1-3 months, this vaccine stimulates the appearance of passive mouse-protection antibodies (below an index of 10) and passive haemagglutinins in 60%-65% of human subjects. Recent experiences in Viet-Nam demonstrate that personnel vaccinated with the USP vaccine, although frequently exposed, enjoy almost complete freedom from the disease. One of the 4 known and confirmed cases of bubonic plague in North Americans occurred in an unvaccinated individual. Among individuals inoculated with the USP vaccine, 2 confirmed cases of pneumonic plague and 1 case of asymptomatic pharyngeal plague have been recorded. The incidence of plague in the Republic of Viet-Nam during the past 3 years is estimated at 13 263 cases in a population in part vaccinated with a live plague which exhibited inadequate immunogenic efficacy in experimental tests.


Effect of massive doses of bacteriophage on excretion of vibrios, duration of diarrhoea and output of stools in acute cases of cholera. Each member of a group of 8 patients with acute cholera was treated with a mixture of four cholera bacteriophage preparations containing over 2 x 10(12) phage particles/ml. These massive doses were intended to kill immediately all vibrios in the intestine by "lysis from without". The numbers of Vibrio cholerae were drastically reduced rapidly. In 4 patients, V. cholerae was completely eliminated from the stools early in the treatment; the total stool volume and after-treatment of diarrhoea were reduced in comparison with a control group but were higher than in a group of patients treated with tetracycline. In the other 4 patients treated with phage, vibrios disappeard more slowly from the stools and there was no apparent clinical effect of the phage. In all the patients treated with phage, the duration of diarrhoea was longer than in patients in a control group who excreted vibrios for a similar length of time although the stool output was similar. This was interpreted as being due to the persistence of vibrios in foci of infection in the upper intestine.It is concluded that treatment of cholera with massive doses of bacteriophage is not as effective as treatment with tetracycline. However, phage can selectively eliminate the majority of vibrios without affecting the other intestinal flora and without any apparent toxic effect on the patient. Phage might therefore be useful as a research tool.


The causation and importance of nervous lesions in American trypanosomiasis. The final cause of nerve-cell destruction during infections with Trypanosoma cruzi has not yet been definitively established. It seems that a cytotoxic or cytolytic substance contained within the leishmania forms is probably liberated after their disintegration and acts, mainly at a short distance and in high concentrations, on the ganglion cells in the vicinity of the ruptured pseudocysts. Recent studies with the electron microscope favour this hypothesis.The destruction of nerve cells in the central or perpipheral nervous systems or in both is responsible for the so-called "late manifestations" of Chagas' disease, which therefore represent "neuropathies" or Chagas' syndromes, i.e., sequelae of the acute phase of the T. cruci infection.


Demonstration of type-specific influenza antibody in mammalian and avian sera by immunodiffusion. The detection of antibody against the ribonucleoprotein antigen of influenza virus is useful because its type-specificity allows the use of serological surveys to detect evidence of recent infections. Antigenic differences between strains limit the usefulness of the techniques, such as the haemagglutination-inhibition test, that detect antibody against surface antigens.This paper describes an agar-gel precipitation (AGP) test that will detect type-specific antibody in avian or mammalian sera. Convalescent levels of antibody against either type A or B influenza virus were demonstrated in human sera. Positive but inconsistent results were obtained with swine sera. The antigens used in the AGP test are non-infectious and stable. The test is easy and economical to perform. Its sensitivity compares favourably with that of the complement-fixation test using human and equine sera.While not a replacement for any of the serological tests at present in current use, the AGP test should prove useful in a variety of diagnostic and research situations.


Immunodiffusion studies of EB virus (herpes-type virus)-infected and-uninfected hemic cell lines.


Myasthenia gravis and epilepsy.

Myasthenia gravis and epilepsy.


Chlorophyll formation in Euglena gracilis var. bacillaris: effect of chelating agents.


Nomi virus, a virus isolated from an apparently new epizootic respiratory disease of cattle.


Excessive emotion about detergents.

Excessive emotion about detergents.


Transmissible mink encephalopathy: experimental transmission to the squirrel monkey. A progressive, fatal spongiform encephalopathy developed in three squirrel monkeys 11 months after inoculation with primate-passaged transmissible mink encephalopathy agent. The clinical symptoms and histopathologic and electron microscopic findings suggest that this naturally occurring disease of mink has been transmitted experimentally to squirrel monkeys.


Myeloperoxidase: contribution to the microbicidal activity of intact leukocytes. Azide and, to a lesser extent, cyanide inhibit the microbicidal activity of myeloperoxidase and of intact normal leukocytes, but they have little or no effect on peroxidase-negative leukocytes. The contribution of the azide-sensitive (peroxidase-dependent?) systems to the total microbicidal activity of normal leukocytes is considerable. The azide-insensitive antimicrobial systems are more highly developed in peroxidase-negative leukocytes than in normal leukocytes, thus suggesting an adaptation.


Alleviation of pain and prevention of infection after tonsillectomy.


X-ray diffraction and infrared spectroscopy on the callus bone.


Boron trifluoride-methanol for histochemical methylation.


The postnatal differentiation of the Golgi apparatus in the neurons of the hippocampal area of the rat. A histological and histochemical study.


Unidirectional scanning for the microspectrophotometric investigation of enzyme reactions in squamous epithelium.


The ultrastructure of Plasmodium falciparum in splenectomized Aotus trivirgatus monkeys.


Intestinal absorption in malaria. I. The absorption of an amino acid (AIB-i-14C) across the gut membrane in normal and in Plasmodium knowlesi-infected monkeys.


Studies on bovine schistosomiasis in the Sudan.


The immune response of sheep to Trypanosoma vivax.


Ultra-violet induced mutations to growth factor requirement and penicillin resistance in a blue-green alga.


Regulation of the chorismic acid branch-point in aromatic acid synthesis in blue-green and green algae.


Behavioral effects of lesions or cholinergic blockade of the dorsal and ventral caudate of rats.


Accumulation of an organ-specific protein during development of the embryonic chick brain.


Some requisites in systems leading to hybrid formation between bacterial endotoxins.


Tryptophan metabolism during infectious illness in man.


Review of the literature on cryopreservation of bone.


A variance in hamster pouch carcinogenesis in tissue irradiated with 200 KVP x-rays and cobalt-60 x-rays.


Application of lyophilized homogenous osseous-dental transplants to large bones in rabbits and monkeys.


Behavior of microbial aerosols in a -30 degrees C environment.


Electrical activity of vertebrate photoreceptors.


Medical grand rounds from the University of Alabama Medical Center.


Canadian medical economics.

Canadian medical economics.


The clinical use of the Dextrostix method for blood sugar.


The preparation and properties of horse antihuman lymphocyte serum and globulin.


Oxytetracycline microfluorescent comparison of orthodontic retraction into recent and healed extraction sites.


Laser photocoagulation of the iris.

Laser photocoagulation of the iris.


Experimental amblyopia in monkeys. I. Behavioral studies of stimulus deprivation amblyopia.


Lymphoma as a cause of hyphema.

Lymphoma as a cause of hyphema.


Chaplains and long-term care.

Chaplains and long-term care.


Effect of Thiotepa upon clearance of radioactive gold colloid by the reticuloendothelial system.


Macroglobulinemia with hyperviscosity syndrome in a dog.


Synthesis by a clonal line of rat glial cells of a protein unique to the nervous system.


pH dependence of the effect of adenosine triphosphate and ethylenediaminetetraacetate on sodium and magnesium binding by cellular membrane fragments.


The bionomics of Lankesteria culicis and Aedes aegypti.


Radioimmunoassay of human plasma retinol-binding protein. A radioimmunoassay for human plasma retinol-binding protein (RBP) has been developed utilizing a double antibody precipitation technique. RBP was purified 1500- to 2000-fold by procedures described previously. A specific anti-human RBP antiserum was prepared in rabbits by three once-weekly injections of purified RBP emulsified with Freund's adjuvant. RBP was iodinated with (131)I and the RBP-(131)I was purified by gel filtration on Sephadex G-100 after complex formation with human plasma prealbumin. The RBP-(131)I was completely (> 95%) immunoprecipitable in the presence of an excess of specific antiserum, it was not (< 5%) immunoprecipitable in the absence of specific antiserum, and it could be completely displaced from antibody by excess unlabeled RBP. The standard curve obtained in the immunoassay with normal plasma was identical to that with pure RBP. Duplicate samples differed from their mean by 5 +/-5% (+/-SD). There was a quantitative recovery of pure RBP added in varying amounts to normal plasma. The immunoassay accurately measured RBP in amounts of 10-100 ng per assay tube. There was no significant difference in the immunoreactivity of apo-RBP as compared to holo-RBP. The mean plasma values (+/-SEM) for a group of 76 normal subjects were 47.2 +/-1.6 mug/ml for males and 41.6 +/-1.6 mug/ml for females. Plasma RBP levels were markedly depressed (15 +/-2.3 mug/ml) in 14 patients with acute viral hepatitis. There was a highly significant correlation between the plasma levels of RBP and of vitamin A in both normal subjects and patients with hepatitis. In all subjects plasma RBP was generally saturated with retinol. The data suggest that under normal circumstances RBP circulates almost exclusively as the holoprotein.


Inherited human cancer.

Inherited human cancer.


Experimental investigation of the effects of intra-articular hydrocortisone and high condylectomy on the mandibular condyle.


Treatment of oral ulcerations with Bacid (Lactobacillus acidophilus).


Biologic effects of endodontic procedures on developing incisor teeth. I. Effect of partial and total pulp removal.


The morphogenesis of the vascular supply to the permanent teeth of Macaca rhesus.


Erythrocyte life span and label elution in monkeys (Macaca mulatta) and cats (Felis catus) determined with chromium-51 and diisopropyl fluroophosphate-32.


Comparison of the lymphocyte transformation test with the tuberculin test in rhesus monkeys and chimpanzees.


Posterior paravertebral ossification in the cervical region--in a Caucasian patient.


Role of the intracellular distribution of hepatic catalase in the peroxidative oxidation of methanol.


Amphotericin B oral suspension in the treatment of thrush.


Duration of estrogenic effect following oral and intramuscular quinestrol administration.


A controlled study of the safety and efficacy of acetylcysteine-isoproterenol combination.


A collaborative investigation of fenfluramine. Anorexigenic with sedative properties.


The antitussive activity of diviminol (Z.424).


Preliminary experience with glyburide (HB-419).


Clinical evaluation of doxepin and amitriptyline in depressed patients.


The action of L-dopa on schizophrenic patients (a preliminary report).


The use of SU 17595 A in the treatment of psychiatric disorders.


Serum concentrations and recovery in urine of four tetracycline analogues.


The molecular constancy of fibrinopeptides A and B from 125 individual humans.


Cross-reactions between human and animal plasma proteins. 3. The relations between ontogenetic and phylogenetic development.


Serological studies in pigs with Mycoplasma hyopneumoniae.


Two men with lead poisoning.

Two men with lead poisoning.


Immunosuppressive methods and antilymphocytic serum.


A new method for the determination of serum nucleotidase. IV. Evaluation of the conditions for assays using adenosine deaminase.


Phosphorylase activity of the subendocardial myofibrils in infarction and in strangulation.


A clinical comparison of cluster headache and migraine.


Evidence for the viral etiology of leukemia in the domestic mammals.


Accounting for the rise in selected medical care expenditures, 1929-1969.


The surgical aspects of multiple neurofibromatosis.


A plaque assay of equine arteritis virus in BHK-21 cells.


Salmonid viruses: double infection of RTG-2 cells with Egtved and infectious pancreatic necrosis viruses.


Sulphonamide complexes of human carbonic anhydrases. Ultraviolet difference spectroscopy.


Studies on the elastase-serum protein interaction. II. On the digestion of human a2-macroglobulin, an elastase inhibitor, by elastase.


Water intoxication and grand mal seizure due to oxytocin.


The importance of immunochemical analysis in the differential diagnosis of microglobulinic myelomas.


(51Cr)EDTA, (hydroxymethyl-14C) inulin and inulin-T for the determination of glomerular filtration rate.


Experimental radiotherapy of a rat rhabdomyosarcoma with 15 meV neutrons and 300 kV x-rays. II. Effects of ractionated treatments, applied five times a week for several weeks.


An investigation of the reversal of the hepatic venous circulation in the isolated perfused dog liver.


Kinetics of complex formation between human carbonic anhydrases and aromatic sulfonamides.


Ultrastructural localisation of carbonic anhydrase in rat stomach parietal cells.


Reimplantation of teeth in the baboon.

Reimplantation of teeth in the baboon.


Biosynthesis of 3-hydroxy-3-methylglutarate and mevalonate by rat liver homogenates in vitro.


A method for preparing monospecific antisera to Cl esterase (Cls): microheterogeneity of purified Cls.


American trypanosomiasis. An historical and a human lesson.


Bacteriuria in pregnancy.

Bacteriuria in pregnancy.


X-ray studies of crystalline proteins.

X-ray studies of crystalline proteins.


The rate of the chloride shift of respiration studied with a rapid filtration method.


Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity. Erythrocytes infected with chloroquine-sensitive Plasmodium falciparum bind chloroquine with an apparent intrinsic association constant of 1.5 x 10(7) liters per mole. Such high-affinity binding of chloroquine is absent or deficient in uninfected erythrocytes and in erythrocytes infected with chloroquine-resistant Plasmodium falciparum.


Rapid screening test for detecting hepatitis-associated antigen. Hepatitis-associated antigen can be detected within 2 hours by using an electrophoretic technique and cellulose acetate membranes saturated with antibody. The speed of the technique now allows testing of blood intended for transfusion on the day of collection, and the sensitivity of the method compares favorably with standard immunodiffusion.


Nasal mites parasitic in nasal and upper skull tissues in the baboon (Papio sp.). Nasal mites (Rhinophagus sp.) were found within the mucosal and submucosal nasal tissues and bone marrow of the upper skull in two of five adult baboons (Papio sp.).


Prolactin localization in the primate pituitary by immunofluorescence. Cells which contain prolactin were clearly distinguished from those which contain growth hormone in adult monkey pituitary glands by means of histologic and fluorescent antibody techniques. The results indicate that in primates, as well as in other mammals, prolactin is immunochemically distinguishable from growth homone.


Phylogeny and morphogenesis in the algae.


Trypanosomiasis.

Trypanosomiasis.


On biological nitrogen fixation in nature, particularly in blue-green algae.


Identification and characterization of phospholipase D in a unicellular red alga (Porphyridium cruentum).


The slow spike-wave complex as a correlate of frontal and fronto-temporal post-traumatic epilepsy.


Demonstration of diffusible antigen from field cases of rinderpest in Nepal.


The lipids of Mycobacterium tuberculosis BCG: fractionation, composition, turnover and the effects of isoniazid.


Hepatitis-associated antigen (Australia antigen) in mother and infant.


Rifampin in the treatment of drug-resistant mycobacterium tuberculosis infections.


Development of glomerular filtration rate and electrolyte and osmolal clearance in the late-embryonic and newly hatched chicken.


Evidence for control of synthesis of the varible regions of the heavy chains of immunoglobulins G and M by the same gene. Previous work indicated that the light chains of a monotypic immunoglobulins G2-K and M-K from a single patient (Ti1) are identical. Our present data show that the monotypic immunoglobulins G and M share idiotypic determinants not present in their isolated light chains or in any of a large number of other immunoglobulins tested, and that amino acid sequences of the first 27 residues from the NH(2)-terminal end of the gamma- and mu-chains are identical. These results support the hypothesis that at least two genes control the synthesis of each heavy and light chain and suggest that the monotypic immunoglobulin G and monotypic immunoglobulin M of this patient share three of the four genes involved. It is proposed that, during normal immunoglobulin synthesis, different cells of a single clone synthesize immunoglobulins M and G, and that the light chains and the variable segments of the heavy chains of the proteins of the two classes are identical within the clone. A genetic switching mechanism is suggested.


Bacillus subtilis mutant altered in spore morphology and in RNA polymerase activity. A Bacillus subtilis mutant, that was selected for rifampin resistance produces spores with an altered morphology. The mutant spores are pleomorphic and differ both in shape and size from the wild-type spores. They frequently have an exosporium that is usually absent from wild-type spores. The mutant spores are similar to the wild-type spores in heat resistance, dipicolinic acid content, and density, but exhibit a slower rate of germination, outgrowth, and growth. In vitro studies show that the RNA polymerase of the mutant is resistant to rifampin inhibition, whereas the wild-type enzyme is completely inhibited by low concentrations of the antibiotic. Rifampin resistance and the altered spore morphology are contransformed with 100% frequency, suggesting that the altered morphology is caused by an alteration in the RNA polymerase.


Effects of combined frontal and temporal lesions on learned behaviors in rhesus monkeys. Delayed response ability, and to a lesser extent visual discrimination performance, is seriously impaired by extensive bilateral damage to the frontal lobes. Reciprocal anatomical connections between the frontal and temporal lobes suggested that massive lesions in both lobes might produce an impairment more complete than that resulting from frontal lobectomy alone. Five monkeys were given combined bilateral frontal and anterior-temporal lesions, and were found to be inferior to both frontal lobectomized monkeys and to unoperated controls on the object discrimination task. The combined lesion did not increase the deficit on delayed response over that obtained after only bilateral frontal lobectomy. Results indicate that the anterior-temporal neocortex is involved in the mediation of visual discrimination ability.


A fatal complication of hyperalimentation: a case report.


Production of extracellular proteolytic enzymes from two strains of oral streptococci.


Toxoplasma gondii in tissue culture and maintenance at low temperatures.


Vascular supply to the optic nerve of primates.


Fluorescein angiography in experimental ocular hypertension.


Ocular pathology of Patau's syndrome with an unbalanced D-D translocation.


Ocular and cerebral abnormalities in chromosome 18 deletion defect.


Kidney function in the squirrel monkey before and after hemorrhagic hypotension.


Passive transfer of hypersensitivity by cells enclosed in membrane chambers.


Evaluation of model systems for study of airway epithelium, cilia, and mucus.


The validity of the indicator dilution method for measuring the capillary diffusion capacity for 51Cr-EDTA in hyperaemic skeletal muscle.


Placenta biloba in uterus arcuatus with special investigation of the fetal membranes.


Hyperactivity of Aedes aegypti (L.) males induced by chemosterilization with thiotepa.


A note on the sarcoptid mites of Primates.


Determination of in vivo alterations in a phenotype of human spermatozoa.


Assay of algal nitrogen fixation in the marine subtropics by acetylene reduction.


Possible evolutionary significance of polyunsaturated fatty acids in blue-green algae.


High-titer anti-D plasma for the prevention of Rh isoimmunization.


Rho (D) immune prophylaxis. A double-blind cooperative study.


Endometrial carbonic anhydrase after diethylstilbestrol as a postcoital antifertility agent.


Chronically impaired uterine artery blood flow. Effect on uteroplacental circulation and pregnancy outcome.


Critical decisions in liver trauma. Experience based on 604 cases.


Changes in plasma and extracellular fluid volumes in patients with essential hypertension during long-term treatment with hydrochlorothiazide.


A study in clinical cancer immunotherapy.


Biosynthesis of ubiquinone-10 from p-hydroxybenzoic acid by leucocytes of the human and rhesus monkey.


Vitamin B6-amino acid-peptide interrelationships in Streptococcus faecium 0 51.


Effects of bilateral lesions of the frontal granular cortex on the social behavior of rhesus monkeys.


Fine structure of spermatogonia and intercellular bridges in Macaca nemestrina.


The rubro-olivo-cerebello-rubral loop and postural tremor in the monkey.


Chronic hemodialysis unit.

Chronic hemodialysis unit.


Altered absorption of drugs from the rat small intestine by carbonic anhydrase inhibition.


Spermagglutinating activity in some human sera.


Laboratory diagnosis and management of bacterial infections.


Quantitative urine culture. An attempt to preserve the status quo of bacterial counts in urine samples by the use of disodium calcium edathamil.


Is a new physiopathologic interpretation of obstructive diseases of the arteries possible? Two cases of thromboangiitis obliterans treated with polarizing solution and coronary vasodilators.


Pharyngoesophageal diverticulum in each of three sisters. Report of cases.


Prepackaged tube feedings.

Prepackaged tube feedings.


Variability of pseudocholinesterase.

Variability of pseudocholinesterase.


Drugs in the management of angina pectoris.


Ultrastructural studies on the long term effects of sodium glutamate on the rat retina.


Liver ultrastructure and RNA labelling after partial hepatectomy in protein-fed and protein-deprived rats.


Electron microscopic studies of cytoplasmic filaments and fibers in different cell types of fracture callus in the rat.


Oxygen consumption and histological studies of mouse skin during the induction of cutaneous sarcoma with methylcholanthrene.


Comparative observations on the production of fever by bacterial pyrogens and leucocytic pyrogen in goats and rabbits.


Reversible inhibition in bimolecular rapid equilibrium random order enzyme systems. The effect of substrate-substrate and inhibitor-substrate interactions. A model is presented that accounts for all types of reversible inhibition by a single inhibitor molecule in bimolecular rapid-equilibrium random-order enzyme systems. The characterization of inhibition mechanisms by graphical methods is examined, and a system of nomenclature is suggested.


Human listerial infection: four cases of meningitis and a review.


Studies on mammalian glucoamylases with special reference to monkey intestinal glucoamylase. 1. Highly purified preparations of glucoamylase were obtained from liver, spleen and intestine of the monkey. The enrichment factor was lower for intestine (60-fold) compared with that of liver (1200-fold) and of spleen (2000-fold) but the final specific activities were of a similar magnitude. 2. The liver and spleen enzymes had maximum activity at pH4.8 whereas the intestinal enzyme showed an optimum at pH5.8. The K(m) values for both starch and maltose with spleen and liver enzymes were higher than for the intestinal enzyme. With the intestinal enzyme, the V(max.) values were higher for both starch and maltose than those of the spleen and liver enzymes. 3. Gel filtration on Sephadex G-200 under identical conditions revealed that liver and spleen enzymes emerge from the columns much later than the intestinal enzyme. 4. Evidence is presented that the glucoamylase activity of the intestinal mucosa is exhibited by the maltase II fraction. 5. Tris, pentaerythritol and turanose inhibited glucoamylase from all the three tissues, but turanose inhibited the spleen and liver enzymes to a higher degree than the intestinal enzyme.


Trimethoprim-sulphamethoxazole in enteric fevers. Clinical improvement was rapid in all 13 patients with enteric fever and one with Brucella abortus infection treated with trimethoprim-sulphamethoxazole. There were no side-effects of the treatment and it was found easy to administer to toxic and delirious patients.


Prophenolase and the role of Mehlis' gland in helminths.


Some characteristics of the "lymphoid tumour" inducing agent of Xenopus laevis.


Correlation between electrophoretic mobility and heavy chain sub-classes of residual IgG from patients with severe hypogammaglobulinaemia.


Giant duodenal ulcer.

Giant duodenal ulcer. Twenty-five cases of benign giant duodenal ulcer have been studied. In every case a barium meal examination showed an ulcer crater with a radiographic diameter of at least 2 centimetres. Abdominal pain was the commonest symptom but less than half of the patients had had pain characteristic of chronic peptic ulcer. Haemorrhage from the ulcer occurred in a large majority of them. The radiological appearances are described, and it has been shown that the giant ulcer may be missed through being mistaken for the duodenal cap or else misdiagnosed.It appears that the death rate in this condition has been falling but it is still high. The management of patients with giant ulcers is discussed.


On the class specificity of anti-immunoglobulin antisera.


Immunological studies of insoluble lipoproteins. 3. Characterization of the lipoprotein-bound thyroid gland-specific antigen.


Bilateral tibiotarsal fracture in a wallaby.


Trichospirura leptostoma, a nematode of the pancreatic ducts of marmosets (Saguinus spp.).


Epizootic of acanthocephaliasis among primates.


Dysphagia in a woolly monkey (Lagothrix lagotricha) following a caustic esophageal burn.


Tuberculosis in an owl monkey (Aotus trivirgatus).


Fluke (Gastrodiscoides hominis) infection in a rhesus monkey with related intussusception of the colon.


Surgical removal of the maxillary canine tooth in the rhesus monkey (Macaca mulatta).


Atypical mycobacterial infection in the pig-tailed Macaque (Macaca nemestrina).


Fatal asphyxiation in a baboon (Papio anubis) caused by a laryngeal peduncular fibroma.


Healing of severed human arterial ends and re-establishment of circulation without arterial suture.


Nitrogen balance during parenteral administration of racemic and 1-isomeric amino acids.


Some principles of modern parenteral nutrition.


The value of parenteral nutrition in patients with gastro-intestinal diseases.


Some remarks concerning parenteral nutrition.


Clinical and experimental studies on complete parenteral nutrition.


Studies on aldosterone biosynthesis in vitro.


Experimental amblyopia in monkeys. II. Behavioral studies in strabismic amblyopia.


Discussion on new methods of glaucoma surgery.


V. General discussion of glaucoma surgery.


The fine structure of Leucocytozoon simondi. II. Megaloschizogony.


Measurement of erythrocyte survival during open-heart surgery.


Genetic and base sequence homologies in bacillus.


Synthetic schistosomicides. XVII. N-(benzylidene and cinnamylidene)-N'-[2-(diethylamino)ethyl]-1,4-naphthalenediamines and related Schiff bases.


Synthetic schistosomicides. 18. N-(4-[2-(diethylamino)ethyl]amino-1-naphthyl)amides, N-5,6,7,8-tetrahydro-4-[(3-piperidinopropyl)amino]-1-naphthyl amides, and related amide and urea derivatives.


Osmotic fragility and mouse virulence in enterococcal L-forms.


Release of membrane components from viable Haemophilus parainfluenzae by ethylenediaminetetraacetic acid-tris(hydroxymethyl)-aminomethane. Logarithmically growing Haemophilus parainfluenzae lost 15 to 20% of the phospholipids, demethyl vitamin K(2), cytochrome b, and cytochrome c, and 50% of the lipopolysaccharide when incubated in ethylenediaminetetraacetic acid (EDTA)-tris-(hydroxymethyl)aminomethane (Tris) for 10 min. This loss of membrane components occurred without loss in viability, and the lost components were recovered as membrane fragments in the surrounding buffer. The phospholipids recovered in the membrane fragments had a slightly lower specific activity than the phospholipids in the residue. Lysis of a portion of the cells could not account for the release of membrane components, as the cells lost neither glucose-6-phosphate dehydrogenase activity not deoxyribonucleic acid. The treated cells were osmotically stable and contained the same proportions of the individual phospholipids as pretreatment cells. Prolongation of the EDTA-Tris treatment did not induce further loss of phospholipid or demethyl vitamin K(2), but caused a decrease in viability. If the cells were returned to the growth medium after 10 min, the cells immediately resumed growth at the pretreatment rate. During growth in the recovery period, the phospholipids increased logarithmically in the pretreatment rate. During growth in the recovery period, the phospholipids increased logarithmically in the pretreatment proportions, although there was a marked decrease in the turnover and a shift from the use of extracellular lipid precursors to the use of intracellular pools of precursors.


The fate of penicillin-damaged enterococci in the mouse kidney.


Experimental bacterial mastitis in the mouse.


Sensitivity of meningococci to sodium sulphadiazine and six antibiotics.


The growth of Neisseria gonorrhoeae on unenriched nutrient agar.


Early intracellular events in the replication of T4 bacteriophage deoxyribonucleic acid. VII. 32P suicide stabilization. The relationship between (32)P suicide stabilization and deoxyribonucleic acid (DNA) replication during infection of Escherichia coli by bacteriophage T4 was reinvestigated. Replication of the parental phage DNA was detected at early stages of stabilization.


A low molecular weight tyrosinase isoenzyme.


Unification of foetal and neonatal immunology.


The superficial dorsal muscle group in Formosan monkey. II. Second layer of the superficial muscle group (Mm. atlantoscapulares anterior et posterior and M. rhomboideus).


The suprahyoid muscle group (Mm. suprahyoidei) in Formosan monkey.


Infectivity of infectious bursal disease virus for embryonating eggs.


Quantitation of the coagulation inhibition in vivo due to breakdown products of fibrin.


A preliminary investigation of the effects of near infrared radiation on visual performance. Rep No. 588.


Immunoglobulin therapy in piglets. A methodological and experimental study.


Skin-sensitizing antibodies.

Skin-sensitizing antibodies.


The influence of structure and function in the surgery of the biliary tract.


Inhibition of growth of measles virus by mycoplasma in cell-cultures and the restoring effect of arginine.


The proteins of adenovirus type 5.

The proteins of adenovirus type 5.


Glycoprotein II. The isolation and characterization of a major antigenic and non-haemagglutinating glycoprotein from Phaseolus vulgaris.


Blue skin.

Blue skin.


Organoid naevus syndrome.

Organoid naevus syndrome.


Purification and some properties of hemorrhagic principle I in the venom of Trimeresurus flavoviridis.


Rat epididymal adipose tissue acetyl-CoA carboxylase.


Redistribution of cardiac output during hemorrhage in the unanesthetized monkey.


Heritable disorders of connective tissue. Surgical and anesthetic problems.


Pharmacological significances of peptidase and proteinase in the brain. 4. Effect of bradykinin on the central nervous system and role of the enzyme inactivating bradykinin in mouse brain.


Histochemical studies of conversion of tyrosine and DOPA to melanin mediated by mammalian peroxidase.


Vital biological tool.

Vital biological tool.


Sphingolipid metabolism. II. The biosynthesis of 3-keto-dihydrosphingosine by a partially-purified enzyme from rat brain.


Solubilization and partial purification of human leukaemic specific antigens.


Resistance of mice and rats to challenge by Babesia rodhaini after inoculation with irradiated red cells infected with B. rodhaini.


The serratus posterior inferior in monkey and man, in particular the structure of the digitations of this muscle and their nerve supply.


Carbenicillin (Pyopen) in treatment of severe systemic infections and pyelonephritis due to Pseudomonas aeruginosa and Proteus.


Management of incompatibility in pregnancy according to optical density measurements of the amniotic fluid and serological tests.


Evolution of higher-organism DNA.

Evolution of higher-organism DNA.


Pulmonary hemorrhage in hamsters after exposure to proteolytic enzymes of Bacillus subtilis. Single exposures of Syrian hamsters by aerosol inhalation or intratracheal instillation to proteolytic enzymes of Bacillus subtilis produced massive pulmonary hemorrhage within the first week. Of 46 animals exposed, eight died as a result of extensive hemorrhage. The remainder made uneventful recovery with no apparent residual pulmonary disease 6 weeks after exposure.


Genetically controlled total deficiency of the fourth component of complement in the guinea pig. Guinea pigs with a total deficiency of the fourth component of complement (C4) have been discovered. There was no evidence for the presence of a C4 inhibitor in the serum of these animals. Mating studies indicate that C4 deficiency is transmitted as a simple autosomal recessive trait. A colony of these animals is being established at the National Institutes of Health. They will provide an opportunity to more precisely define the role of complement in immune phenomena and the defense against disease.


Diurnal variation of spontaneous uterine activity in nonpregnant primates (Macaca mulatta). Diurnal variations in the average intrauterine pressure and in the average frequency of contraction were demonstrated in four nonpregnant rhesus monkeys. Uterine activity is lowest between 0400 and 0700 hours and highest between 1400 and 1700 hours. There is statistically significant correlation between uterine activity and diurnal variation in core temperature.


DDT metabolites and analogs: ring fission by Hydrogenomonas. A Hydrogenomonas cleaved one of the rings of p,p'-dichlorodiphenylmethane, a product of DDT metabolism, to yield p-chlorophenylacetate and further metabolized the latter compound. Products of microbial degradation of other diphenylmethanes were also identified. Substituents on the methylene-carbon and para-chloro substitution are critical factors governing resistance of DDT and related compounds to aerobic metabolism and decomposition by the bacterium.


Disc electrophoresis as an aid in the identification of piroplasms.


Degeneration of arterial smooth muscle cells: ultrastructural study of smooth muscle cell death in control and cholesterol-fed animals.


A reversible neutrophil bactericidal defect associated with a mixed cryoglobulin.


Removal of IgM from serum by ultrafiltration.


The enzymic cleavage of the carbon-phosphorus bond: purification and properties of phosphonatase.


Melanosome and lysosome. I. Lysosomal activity in relation to growth of melanoma.


Some aspects of fluid therapy in practice.


Variation of Lf value of tetanus toxin depending on the reference antitoxins for flocculation.


Adjuvant effect and structure of wax D, a lipopolysaccharide of M. tuberculosis.


Oxygen consumption during the initial stage of human leucocyte phagocytosis of polystyrene latex particles.


Quantitation of red cell carbonic anhydrase B. A diagnostic test for hyper and hypothyroidism.


A new finding in Chagas' disease: increased natriuresis during acute saline loading.


Fulminating meningitis with Waterhouse-Friderichsen syndrome due to Neisseria gonorrhoeae.


Isolation of the group-specific polysaccharide of Mycobacterium tuberculosis.


Androgen secretion by the fetal and neonatal rhesus monkey.


Levels of estrogens, progestogens and luteinizing hormone during the menstrual cycle of the baboon.


Thyrotropin and growth hormone releasing activity in hypophysial portal blood.


A study of orally-administered degraded carrageenan in the baboon.


Efficacy of bleomycin in the protection of rice sheath blight disease.


On the mode of action of multhiomycin. I. Effects of multhiomycin on macromolecular syntheses.


Hyperparathyroidism with Albright's osteodystrophy: Case report and a proposed new classification of parathyroid disease.


Purification of hypothalamic releasing hormones of human origin.


Interconvertibility of two different moieties of thyroxine binding alpha-globulin on starch gel electrophoresis.


Comparison of chorionic gonadotrophin in primates.


The antigenicity and cellular localization of human chorionic somatomammotrophin.


Kinetic studies of the in vivo exchange of ribosome subunits in Bacillus megaterium.


Pipe line model of the ribosome cycle.

Pipe line model of the ribosome cycle.


Description of a Naegleria sp. isolated from two cases of primary amoebic meningo-encephalitis, and of the experimental pathological changes induced by it.


Epididymal physiology. I. Specificity of antisera against bull spermatozoa and reproductive fluids.


Morphology of the rhesus monkey ovary near the time of ovulation.


Precipitating antigens of the normal human prostate.


On random fluctuations in EEG and evoked potentials.


Three ectoparasites of veterinary interest communicable to man.


Generalized lymphoedema with yellow nails, pleural effusions, and macroglobulinemia.


Studies of the articular cartilage following infarction of the capital femoral epiphysis in the puppy.


SoME THOUGHTS AND SPECULATIONS ON THE VOICE.


Effect of cobra and rattlesnake venoms on the central nervous system of the primate.


Abortion in cattle associated with Bacillus licheniformis.


Mycoplasmata in poultry-strains WS7 and WR1.


Analysis of corticosteroids.

Analysis of corticosteroids.


Characterization of an acid active deoxyribonuclease from the larval salivary gland of Drosophila hydei.


Incorporation of 35S into mammalian 4-S RNA.


An effect of temperature on the Bacillus subtillis transfer RNA's which respond to codons beginning with U and A correlation with cytokinin activity.


ATP-inhibited ribonuclease of Bacillus subtilis. II. Effect of adenosine triphosphate and other compounds.


Trichophyton phaseoliforme (Dante Borelli & Feo--1966) in Romanian soil.


Selection, characterization and iron-reducing capacity of nitrate reductaseless (nit-) mutants of iron-reducing bacteria.


Natural infection of Rattus rattus by Trypanosoma cruzi in Panamá.


Lesions caused by eggs of the Changhua strain of Schistosoma japonicum in the liver of Formosan monkeys.


Toxocara canis infections in baboons. II. Distribution of larvae and histopathologic responses.


Hong Kong influenza in U.S. military airmen in Thailand.


Prevalence of serum-hepatitis-related antigen (SH) in different geographic regions.


Synchronous cell divisions in Anacystis nidulans Richter.


Serum hepatitis and the Australia antigen.


Receptor sites on human monocytes for complement: binding of red cells sensitized by cold autoantibodies.


Specificity of acquired haemolytic anaemia autoantibodies and their serological characteristics.


Adenosine diphosphate-induced platelet aggregation in suspensions of washed rabbit platelets.


A "new" congenital haemorrhagic condition due to the presence of an abnormal factor X (factor X Friuli): study of a large kindred.


Differences between Rh(D) negative subjects in response to Rh(D) antigen.


5(or 4)-(3,3-bis(2-chloroethyl)-1-triazeno)imidazole-4(or 5)-carboxamide (NSC-82196): microbiologic evaluation and assay.


Insulin levels in primates by immunoassay. Only trace amounts of insulin were detected by an immunoassay system with guinea pig antibody to pork insulin in the New World primates Cebus and Saimiri. The system found insulin levels in the Old World primates rhesus and chimpanzee which were quite like those of human beings. The findings suggest important structural differences in the insulins of the two primate divisions.


Nitrogen balance in patients on maintenance peritoneal dialysis.


The artificial gut in hospital and home. Technical improvements.


An erroneous exclusion of paternity in a Chinese family exhibiting the rare MNSs gene complexes Mk and Ms3.


Uncommon Gm gene complexes.

Uncommon Gm gene complexes.


A rapid radioimmunoassay for measuring nanogram levels of antigens.


The A-B-O blood groups in a baboon colony in France.


A study of the antigenic complexes of intracellular components of beta hemolytic streptococci.


Fetal chephalometry by ultrasound in normal and complicated pregnancy.


Immunochemical determination of serum transferrin in patients with anaemia of pregnancy.


Carbenicillin therapy of Pseudomonas and other gram-negative bacillary infections.


Carbenicillin: a clinical and laboratory evaluation.


Gonococcal arthritis complicating gonorrheal pharyngitis.


Variation in the fixation image of "structured granules" in Anabaena.


Complications of gonorrhea.

Complications of gonorrhea.


Assay and properties of diaminopimelate epimerase from Bacillus megaterium. 1. Diaminopimelate epimerase from a soluble extract of Bacillus megaterium N.C.I.B. 7581 was purified about 25-fold by fractionation with ammonium sulphate and chromatography on calcium phosphate gel-cellulose. The product was impure but was unstable on further purification. 2. Quantitative assay methods for the enzyme were devised in which meso- or ll-diaminopimelic acid may be the substrate. 3. Between 25 degrees and 45 degrees at pH7.0 enzyme action leads to an equilibrium mixture containing 65% meso-isomer and 35% ll-isomer. 4. The initial rate of epimerization was 2-3 times as fast with ll-diaminopimelic acid as substrate as with the meso-isomer; a number of other amino acids were not racemized by the enzyme. The Michaelis constants at 37 degrees were 6.7mm (ll-isomer) and 100mm (meso-isomer); with both substrates enzyme activity was maximal at pH7-8. The relative rates of epimerization of ll-diaminopimelic acid at 25 degrees , 37 degrees and 45 degrees were 0.77:1.00:1.15. 5. A thiol compound (of which 2,3-dimercaptopropan-1-ol was the most effective) was needed as an activator of the purified enzyme. 6. Carbonylbinding reagents and several other compounds did not inhibit diaminopimelate epimerase. 7. Pyridoxal phosphate did not stimulate enzymic activity even in preparations that had been almost completely freed of derivatives of vitamin B(6) (as shown by microbiological assay).


Infantile gastroenteritis.

Infantile gastroenteritis.


Studies on a nucleoprotein prepared from rat liver polysomes by digestion with T1 ribonuclease. 1. Treatment of rat liver polysomes in a buffer containing 2.5mm-magnesium chloride with T(1) ribonuclease at a concentration of 330units/ml. of reaction medium at 37 degrees for 2hr. leads to the production of an insoluble nucleoprotein. 2. On the bases of analysis for protein and RNA and of u.v.-absorption spectra the nucleoprotein appears to have lost approx. 60% of the structural RNA originally present in the ribosome. Degradation of (3)H-labelled polysomes (structural RNA labelled with orotic acid) with T(1) ribonuclease leads to nucleoprotein preparations retaining approx. 30% of the radioactivity originally present in the polysomes. By means of sucrose-density-gradient centrifugation it is shown that the nucleoprotein preparations are free of single 73s ribosomes and ribosomal subunits. No evidence for the presence of 28s and 18s structural RNA was obtained on examination of extracted nucleoprotein-particle RNA by means of sucrose-density-gradient centrifugation. 3. Digestion of washed polysomes carrying (14)C-labelled nascent peptide chains with T(1) ribonuclease gives a nucleoprotein particle that retains approx. 70% of the original labelled chains. Treatment of labelled nucleoprotein particles with 1mm-puromycin in the absence of transfer factors releases 20% of the labelled chains. Addition of GTP (0.48mumole) increases this release to 37%. 4. Treatment of nucleoprotein particles carrying (14)C-labelled peptide chains with either EDTA (50mm) or ammonium chloride (0.5m) brings about a small release of labelled material (approx. 15%). 5. Disruption of nucleoprotein particles carrying (14)C-labelled peptide chains with either sodium dodecyl sulphate or 2m-lithium chloride, followed by addition of transfer RNA as marker and chromatography on Sephadex G-200, show in both cases that considerable amounts of labelled peptide material move well ahead of the added transfer RNA marker. Further, if nucleoprotein particles carrying labelled peptide chains are treated with 0.3m-potassium hydroxide at 20 degrees for 24 hr., neutralized to pH7.6, and then chromatographed on Sephadex G-200, the labelled peptide material moves much closer to the added transfer RNA marker. These results suggest that a proportion of the nascent (14)C-labelled peptides on the nucleoprotein are attached to transfer RNA or large fragments of transfer RNA. 6. [(3)H]Polyuridylic acid binds to nucleoprotein particles in 1mm-magnesium chloride. The rate of binding is rapid when measured at 20 degrees .


Hypothermia, abdominal pain, and lactic acidosis in phenformin-treated diabetic.


Infection in the nursery.

Infection in the nursery.


Cleaning of haemodialysis tubing.

Cleaning of haemodialysis tubing.


Treatment of typhoid.

Treatment of typhoid.


Posthypoxic jugular venous hyperoxia.

Posthypoxic jugular venous hyperoxia.


Regional cerebral blood flow during acute ischemia. Correlation of autoradiographic measurements with observations of cortical microcirculation.


Method for recording and analyzing visual fixations in the unrestrained monkey.


Experimental effects of amphetamine: supplementary report.


Utilization of Egyptian raw by-products for the erythromycin production by Streptomyces erythreus.


Isolation of Listeria monocytogenes from faeces of clinically healthy humans and animals.


Intrauterine transfusion and fetal death. Relationship of intraperitoneal pressure to umbilical vein blood flow.


Extrachorial (circumvallate) placentas in rhesus monkeys.


Amniotic fluid antibody titers and other prognostic parameters in erythroblastosis.


[The role of the auditory projection region of the cerebral cortex in discriminating acoustic signals].


Long-term care of patients with neurological disorders.


Isolation of Brucella abortus from vaginal mucus samples.


Control of rabies.

Control of rabies.


Factors in determining the level of biomedical research support.


Health manpower and research support.

Health manpower and research support.


Further studies on the treatment of streptococcal skin infection.


Endochondral ossification in achondroplastic dwarfism.


Renovascular hypertension in children.

Renovascular hypertension in children.


Ambulatory treatment of lead poisoning: report of 1,155 cases.


Care of the critically ill child: intravenous alimentation.


Study of carbonic anhydrase using perturbed angular correlations of gamma radiation. The angular correlation of the 150-247 kev gamma-ray cascade of (111m)Cd is strongly perturbed when this nucleus is bound to the enzyme carbonic anhydrase. A comparison of the perturbed angular correlation for the apoenzyme with that for native carbonic anhydrase confirms that the (111m)Cd binds at the active region of the enzyme. These results provide good evidence that the perturbed angular correlation reflects the effective molecular rotational correlation time at the metal binding site, and that this radioactive nucleus can be used as a rotational tracer to label biological macromolecules. The qualitative dependence of the perturbed angular correlation of the (111m)Cd cascade on the molecular rotational correlation time at the metal binding site is illustrated using a cadmium-complex solution at various temperatures.


Mechanism of DNA chain growth. IV. Direction of synthesis of T4 short DNA chains as revealed by exonucleolytic degradation. T4 nascent short chains labeled at their growing ends with H(3)-thymidine and uniformly with C(14)-thymidine were prepared, separated into complementary strands, and degraded by E. coli exonuclease I in the 3' to 5' direction or by B. subtilis nuclease in the 5' to 3' direction. The kinetics of release of H(3) and C(14) labels by both enzymes was consistent with the conclusion that the H(3) label is at the 3' end of the nascent short chains of both strands and that the short chains are products of discontinuous synthesis in the 5' to 3' direction along the two template strands.


Sulphonamide-susceptibility of meningococci isolated from patients in the Netherlands, before, during and after an epidemic of meningococcal disease.


Orbital phycomycosis.

Orbital phycomycosis.


Microbodies (peroxisomes) in the toad, Bufo marinus. A cytochemical study.


Hyperlipemia in ponies.

Hyperlipemia in ponies.


Canine Cushing's syndrome.

Canine Cushing's syndrome.


The effect of estrogen and progesterone on the glycogenetic response to prolactin in ovariectomized mice.


Micromorphological studies on the coronary vessels of the camel (Camelus dromedarius). I. Micromorphology of the coronary arteries in camel fetuses.


Techniques for single unit recording in behaving monkeys.


A method for chronic intravenous drug administration in squirrel monkeys.


The etiology of scoliosis.

The etiology of scoliosis.


Inactivation of the scrapie agent by near monochromatic ultraviolet light.


Encephalitis in newborn hamsters after intracerebral injection of attenuated human measles virus.


Somatosensory cortical unit responses of long duration.


Growth of porcine transmissible gastroenteritis (TGE) virus in organ cultures of pig tissue.


Inherited decrease of the binding capacity of thyroxine-binding globulin (TBG).


Comparative studies on the properties of LATS and TSH.


Elevation of the serum alkaline phosphatase coincident with ectopic-bone formation in paraplegic patients.


Mycetoma due to Nocardia brasiliensis.

Mycetoma due to Nocardia brasiliensis.


Determination of Pseudomonas aeruginosa by biochemical test methods. II. Acylamidase test, a modified biochemical test for the identification of Pseudomonas aeruginosa.


Determination of Pseudomonas aeruginosa by biochemical test methods. 3. Utilization of Tween 80 by Pseudomonas aeruginosa.


Health aides. Introduction to a series of papers by authors who have worked with these paraprofessionals.


The development of interaction as an approach to training.


The importance of training for effective performance.


Selected annotated bibliography on health aides.


Guidelines for effective use of nonprofessionals.


Perception of functions of health aides by aides themselves and by others.


Aides--pain or panacea?

Aides--pain or panacea?


Supervision, the key to success with aides.


Podiatry screening project for children in the District of Columbia.


Manual for scoring socioeconomic status for research on health behavior.


Hepatitis associated with illicit use of intravenous methamphetamine.


Evaluating health programs.

Evaluating health programs.


Consumers' motivation and acceptance of urinary screening of school children.


Survival of salmonellae in soft agar.

Survival of salmonellae in soft agar.


Treatment of postnecrotic cirrhosis with 6-mercaptopurine--with a special view to the possible value of long-term treatment with small doses.


Australia-SH-antigen and diseases of the liver. Preliminary investigations of Danish drug addicts and patients with chronic liver diseases.


The pathological diagnosis of acute ischaemic heart disease. Report of a WHO scientific group.


Comparative studies on antigen extracts from some Bulgarian leptospira strains.


Solitary mastocytoma.

Solitary mastocytoma.


Cervical esophagostomy in head and neck cancer.


Characterization of protein bound to rapidly-labelled RNA in polyribosomes from rat liver.


Regulation of purine ribonucleotide synthesis by end product inhibition. 3. Effect of purine nucleotides on succino-AMP synthetase of Bacillus subtilis.


Serum accessory factors in the measurement of arbovirus neutralization reactions.


Ketamine hydrochloride (Ketalar).

Ketamine hydrochloride (Ketalar).


Effect of organic mercury compounds in serological tests on some isometric plant viruses.


Effects of N-ethoxycarbonyl-3-morpholinosyndnonimine (SIN-10) on the cardiovascular system.


Effect of immunosuppressive drugs on infection in mice by M. marinum (balnei), M. tuberculosis and M. leprae.


External megavoltage radiation therapy in the treatment of carcinoma of the cervix.


A review of 806 caesarean operations performed at the Queen Victoria Maternity Hospital, Adelaide, in the years 1965-1969.


Rapid diagnosis of Candida albicans.

Rapid diagnosis of Candida albicans.


Absorption of 51Cr-EDTA in ulcerative colitis following rectal instillation.


Resistance to cycloserine.

Resistance to cycloserine.


Experiences of the cycloserine sensitivity tests performed at the second chemotherapy trial of the IUAT.


Tubercle bacilli resistance to cycloserine.


In vitro studies of the possibility of using cycloserine as a tuberculostatic in combination with intermittent therapy of tuberculosis.


Experimental comparative study of the concentration of cycloserine in the serum and viscera in conventional laboratory animals and in the monkey.


Pharmacological considerations on cycloserine.


Anatomo-histological effect of cycloserine on experimental tuberculosis lesions.


Bacteremia following dental extraction and its prophylaxis.


Ovarian hormones and female sexual invitations in captive rhesus monkeys (Macaca mulatta).


A fluorescent antibody method to distinguish vegetative cells from spheroplasts of an Escherichia coli strain.


Elimination of mycoplasma from various cell cultures.


Purification of allantoicase from Pseudomonas aeruginosa.


Improved automatic inoculator for bacterial cultures. A simple automatic inoculator which allows the simultaneous inoculation of several cultures with identical or different inocula is described. The use of Teflon spaghetti tubing allows great flexibility in handling and placing of components. The inoculator can be adapted to handle aerobic and anaerobic bacteria.


Dubos oleic acid agar medium in the differentiation of meningococci and gonococci. Growth on Dubos oleic acid agar plates, incubated for 48 hr at 37 C in candle jars, provides a method for differentiating meningococci from gonococci. All of our 54 strains of meningococci, but none of the 49 strains of gonococci, grew on this medium.


Pesticinogeny: a characteristic useful for presumptive identification and isolation of Pasteurella pestis. Current methods of identifying Pasteurella pestis rely heavily on tests specific for detecting fraction I, the envelope antigen. Pesticin I, a bacteriocin inhibitory for P. pseudotuberculosis, has been demonstrated in nearly all tested strains isolated from human infections. The results of using this characteristic as an identifying trait for P. pestis were compared with results reported for detecting fraction I by fluorescent-antibody and antiserum-agar techniques. Data indicate that, although certain atypical strains of P. pestis fail to react in one system or the other, a combination of these tests provides positive identification in all cases. Detection of P. pestis in contaminated materials is greatly facilitated, and the simplicity of this test makes it a valuable tool in the study of plague infections and an important adjunct to methods currently in use. The use of the pesticin I assay is not intended to replace other accepted techniques, but rather to supplement them and increase the effectiveness of plague investigation.


Plaque assay for Q fever and scrub typhus rickettsiae. The plaque assay procedure developed for spotted fever and typhus group rickettsiae is also appropriate for scrub typhus and Q fever rickettsiae. The plaque titers of suspensions of Rickettsia tsutsugamushi and Coxiella burnetii compared favorably with end points obtained by titrations in mice.


Comparison of cephalexin, penicillin V, and ampicillin in streptococcal infections in monkeys. Intravenous inoculation of a group A hemolytic streptococcus caused lethal infections in all of 11 untreated monkeys. Daily intragastric administration of either 25 or 50 mg per kg per day, given in two equal morning and afternoon doses, yielded similar results in monkeys treated with cephalexin, penicillin V, and ampicillin; all eight monkeys in each therapy group survived. At dose levels of 12.5 mg per kg per day, six of eight, four of eight, and one of eight receiving cephalexin, penicillin V, and ampicillin, respectively, died. The differences observed at the lower dose level between cephalexin and ampicillin could be attributed, in part, to differences in the minimal inhibitory concentrations (MIC) of cephalexin (MIC = 0.24 mug/ml) and ampicillin (MIC = 0.01 mug/ml). The differences in results between penicillin V, which had the same MIC as ampicillin, could perhaps be attributed, in part, to shorter duration of antibacterial activity and higher protein binding of penicillin V. These studies support previous observations that cephalexin at 25 to 50 mg/kg doses is effective in severe streptococcal sepsis in monkeys.


Numerous multiple hairs.

Numerous multiple hairs.


Sulfolipid I of Mycobacterium tuberculosis, strain H37Rv. I. Purification and properties.


Sulfolipid I of Mycobacterium tuberculosis, strain H37Rv. II. Structural studies.


Inhibition of prostaglandin biosynthesis by 8cis, 12trans, 14cis-eicosatrienoic acid and 5cis, 8cis, 12trans, 14cis-eicosatetraenoic acid.


Role of cobra venom direct lytic factor and Ca2+ in promoting the activity of snake venom phospholipase A.


Observations with a variant of lymphocytic choriomeningitis virus in mouse tumors.


On protein targets of chemical carcinogens: dissimilar molecular sizes of the principal protein conjugates.


Purification of rat liver acetyl coenzyme A carboxylase and immunochemical studies on its synthesis and degradation.


Inhibition and modification of human carbonic anhydrase B with bromoacetate and iodoacetamide.


Reduction of cytochrome c by ferrous ions and ethylenediaminetetraacetic acid in acid solution.


Complement fixation and immunodiffusion tests for assay of hepatitis-associated "Australia" antigen and antibodies.


Frequency of single spleen cells from hyperimmune rabbits producing antibody of two different specificities.


Receptor sites for complement on certain human peripheral blood lymphocytes.


Patterns of serologic specificity of human gamma-G erythrocyte autoantibodies. Correlation of antibody specificity with complement-fixing behavior.


Molecular taxonomy of Triatominae (Hemiptera: Reduviidae).


Hyalomma (Hyalommina) rhipicephaloides Neumann (Ixodoidea: Ixodidae): its identity, hosts, and ecology, and Rickettsia conori, R. prowazeki, and Coxiella burneti infections in rodent hosts in Egypt.


Membrane-complement fixation test for hepatitis associated antigen.


Phenolase inhibitors.

Phenolase inhibitors.


Heparin therapy in septicemia with disseminated intravascular coagulation.


Immunology of Bacillus cereus beta-lactamases.


Monkey uricase.

Monkey uricase.


Clinical, radiographic, histologic, and electron microscopic observations of plastic tooth implantations in baboons.


Microfilarial infection of the oral structures in the cotton top marmoset (Saguinus oedipus).


Dental health education. Report of a WHO Expert Committee.


Subcellular localization of individual mannose-containing phospholipids in Mycobacterium tuberculosis.


Simplified method for obtaining cell wall tuberculins from mycobacteria.


Influence of the medium on the in vitro susceptibility of Mycobacterium tuberculosis to ethambutol.


Terminal synthesis of xanthommatin in Drosophila melanogaster. I. Roles of phenol oxidase and substrate availability.


Hydrazine toxicology--another episode.

Hydrazine toxicology--another episode.


Quantitative determination of C-reactive protein (CRP) by micro-double diffusion technic.


Mixed monoclonal-polyclonal gammopathy.

Mixed monoclonal-polyclonal gammopathy.


Metabolism of histidine in x-irradiated rats in relation to histamine and diamine oxidase.


A new method for determining the distribution of allergenic fractions in biological materials: its applications to grann pollen extracts.


Acetic acid for quantitiative gel radial immunodiffusion determination.


Techniques and interpretations in the serological diagnosis of brucellosis in man.


Long-chain mutants of Streptococcus faecalis induced by ultraviolet irradiation.


The effects of a new drug (hexobendine) on cerebral hemodynamics and oxygen consumption.


The detection of the Rh antigens C, Cw, c, D, E, e and the antigen S of the MNSs system, in bloodstains.


Effects of long-term continuous inhalation of ozone on experimental animals.


Oral toxicology studies with lapachol.

Oral toxicology studies with lapachol.


The absorption, distribution, and excretion of 3-trifluoremethyl-s-triazolo(3,4-alpha)isoquinoline.


Air cleaning devices for reduction in number of airbone bacteria.


Primary drug resistance: a continuing study of drug resistance in tuberculosis in a veteran population within the United States. VII. September 1965 to September 1969.


Psychiatric and mental health nursing. Hope for the chronic patient in the community mental health center.


Investigation of nephrotoxic effects of adenine and its metabolic product, 2,8-dioxyadenine, on primates (Macaca irus).


Sequence of events after pulp exposure in monkeys.


Concrements resulting from suture material in the biliary tract. A clinical and experimental study.


Purification of a blue-green algal deoxyribonucleic acid photoreactiving enzyme. An enzyme requiring light as a physical cofactor to perform its catalytic function.


Reassembly in vitro of a serum high-density lipoprotein.


Relation to taraxein to schizophrenia.

Relation to taraxein to schizophrenia.


Biosynthesis of isoleucine and valine in Mycobacterium tuberculosis H37Rv. II. Purification and properties of acetohydroxy acid isomerase.


Intraocular fluid dynamics. I. Steady-state concentration gradients of magnesium, potassium and calcium in relation to the sites and mechanisms of ocular cation transport processes.


Peroxidase passage through the outflow channels of human and rhesus eyes.


Effects of norepinephrine, isoproterenol and sympathetic stimulation on aqueous humour dynamics in vervet monkeys.


51Cr EDTA and 51Cr DTPA: renal diagnostic agents influence of the method of preparation on their biological behaviour.


Frass and infection in relation to juvenile characteristics in adult Tenebrio molitor.


Observations on the maturation of thyroid function in early fetal life. Serum samples were obtained from 21 normal human fetuses after therapeutic abortion for psychiatric indications. Fetal crown-rump length ranged from 5.2 to 22.5 cm, corresponding to the gestational age of 65-168 days.Serum thyroxine, assayed by a modification of the Murphy-Pattee method, was identified in the second smallest fetus examined at 78 days gestation. Thereafter it increased rapidly, maintaining a significant linear correlation with crown-rump length until term (r = 0.800, P < 0.001). Free thyroxine (FT4) also increased in a linear relation to gestational age (r = 0.908, P < 0.001), but reached term levels by 18-20 wk. Radioimmunoassayable thyroid-stimulating hormone (TSH) was detected at 78 days gestation. Levels increased rapidly with advancing gestation, so that by 16 wk almost all were within the range of term infants. After 16 wk gestation, levels were usually greater than 4.0 muU/cc, higher than that seen in normal children. No correlation was demonstrated between the serum TSH levels and total thyroxine. TSH and FT4, however, increased in a parallel manner with a significant positive correlation. This suggested that fetal TSH secretion was responsive to FT4 levels from very early in gestation, possibly as early as 11 wk.Thyroxine-binding globulin (TBG) was detected in a fetus of 78 days gestation (1.4 mug/100 ml). Levels increased rapidly, paralleling the rise in serum thyroxine and maintaining a linear correlation with crownrump length (r = 0.864, P < 0.001). Thyroxine-binding prealbumin binding capacity (TBPA) in fetuses 14-24 wk gestation was comparable with that seen at term. When examining the distribution of tracer amounts of thyroxine-(131)I (T4-(131)I) between the thyroxine-binding proteins, it was found that a major fraction was bound to TBPA and albumin during the early part of gestation. This decreased linearly with maturation of the fetus as the fraction bound to TBG increased. By 20 wk gestation fetal TBG was able to bind 78% of tracer despite a TBG capacity of only 7.7 mug/100 ml. This appeared to be the result of relatively low concentrations of TBPA and albumin during this period of gestation. The theoretical association constant calculated for fetal and newborn TBG was found to be similar to that estimated for normal adult males and females.


The action of oxyphenylbutazone on immunological responses.


Whose dollars for health?

Whose dollars for health?


Social workers and the long-term care facility: a social service sampler.


Oxygen utilisation and metabolic acidosis after exercise in pigs.


Inhibition of Bacillus megaterium by a trimethylamine oxide-associated browning reaction product. Heated combinations of trimethylamine oxide (TMAO) and culture media (tryptone, glucose, yeast extract broth or a defined minimal medium), or heated TMAO and glucose, contained substance(s) that inhibited growth of Bacillus megaterium. Inhibition was expressed primarily as an increase of the lag phase of growth; the logarithmic growth rate was comparable to control cultures. The addition of unheated TMAO to the culture media had no effect on growth. Results suggested that TMAO was decomposed during heating and that dimethylamine, one of the degradation products, reacted with glucose by a Maillard-Amadori reaction to produce the inhibitory substance(s).


Survey of the sensitivity of microorganisms to rubratoxin B. Of the 133 microorganisms tested, Tetrahymena pyriformis and Volvox aureus were the most sensitive to rubratoxin B, being inhibited at 25 and 50 mug/ml, respectively.


Antigenic variation in group A streptococci: types 11 and 9. A strain of group A Streptococcus which was virulent but M-nontypable was isolated from patients in a hospital nursery during an epidemic. This strain, Boston 11, reacted in T-agglutination tests with antisera for types 9 and 11, an unusual combination. A comparison of this strain with Lancefield's M-11 strain (NCDC SS-721) and Alabama 11 (Provisional 61) revealed three serologically related but distinct strains. Antiserum produced with the Boston 11 strain exhibited similar reactivity with all three "11" strains as well as with M-9 (SS-501) as demonstrated in precipitin tests. Immunodiffusion studies indicated that the Boston 11 antigen was partially identical with the M-11 and M-9 strains and shared at least one antigen with the Alabama 11 strain. The Boston 11 antiserum could be made specific for precipitin tests, but bactericidal activity for the Alabama 11, M-11, and Boston 11 strains was essentially negative.


Simplified procedure for preparation of specific antibodies to gamma globulins. Antibodies were prepared to rhesus monkey, rabbit, dog, and hamster gamma globulins which had been purified by agar-block electrophoresis. Immunoelectrophoretic analysis demonstrated that these antisera were specific for gamma globulin components in whole serum. The use of these antisera as secondary serological reagents was examined.


Australia antigen in a closed adult population monitored for serum glutamic oxalacetic transaminase. A study of the presence of Australia antigen (Au/SH) was conducted over a period of 21 weeks among volunteer plasma donors living in a prison and being monitored for serum glutamic oxalacetic transaminase (SGOT). A good correlation was observed between the level of SGOT and presence of Au/SH, the latter being present in 33% of donors with SGOT values higher than 101 Karmen units and in 12% of those with SGOT values of 41 to 100 units. Furthermore, none of the 87 donors with all SGOT values below 40 was found positive for Au/SH. It should be noted, however, that single specimens only were tested from 72 of the 87 individuals. Au/SH was detected with equivalent efficiency by both agar gel precipitation and complement fixation procedures. Implications of these findings in the prognostication of hepatitis carrier state are discussed.


Homogenous bacterial aerosols produced with a spinning-disc generator. Aerosols composed of viable particles of a uniform size were produced with a commercial spinning-disc generator from aqueous suspensions of Bacillus subtilis var. niger spores containing various amounts of an inert material, dextran, to regulate aerosol particle size. Aerosols composed of single naked spores having an equivalent spherical diameter of 0.87 mum were produced from spore suspensions without dextran, whereas aerosols produced from suspensions containing 0.001, 0.01, 0.1, and 1% dextran had median diameters of 0.90, 1.04, 1.80, and 3.62 mum, respectively. Such aerosols, both homogeneous and viable, would be useful for calibrating air sampling devices, evaluating air filter systems, or for employment wherever aerosol behavior may be size-dependent.


Susceptibility of Pseudomonas aeruginosa to gentamicin sulfate in vitro: lack of correlation between disc diffusion and broth dilution sensitivity data. Seventy-eight of 420 clinical isolates of Pseudomonas aeruginosa yielded zones of inhibition of less than 12 mm in diameter around 10-mug discs of gentamicin sulfate when tested by the standardized Bauer-Kirby disc diffusion method. Of 153 strains chosen from these isolates, one strain (0.65%) required 25 mug of gentamicin per ml for inhibition; the remainder (99.35%) were inhibited by 6 mug/ml or less of the antibiotic. It is recommended that those isolates of P. aeruginosa that yield zones of inhibition less than 12 mm in diameter be disc susceptibility-tested once more; those isolates that give zones of inhibition of less than 12 mm upon repeated examination should then be subjected to the broth dilution test before they are designated as sensitive or resistant to gentamicin.


Interactions between an influenza A-2 virus and rhesus monkey kidney cells.


Bovine ephemeral fever. I. Characteristics of the causative virus.


Buoyant density studies on equine arteritis virus.


Action of amino acids on the viability of thymine starved Bacillus subtilis cells.


Properties and state of particulate tyrosinase of xanthic goldfish.


Purification and properties of deoxyriboaldolase from human erythrocytes.


The isolation of arylsulphatase isoenzymes from Pseudomonas aeruginosa.


Double-blind comparison between 4-allyloxy-3-chlorophenylacetic acid (alclofenac) and phenylbutazone in osteoarthritis.


Antibiotic suppositories in childhood infections.


A controlled evaluation of the analgesic activity of diviminol (Z424) based on the responses to the ischaemic test.


Urinary tract infections in children: experience with nalidixic acid.


Prevention of recurrent weight gain with large doses of synthetic thyroid hormones.


Differential drug effects on social and symptomatic behaviors.


A comparative study of fluphenazine-amitriptyline combination and amitriptyline alone in the treatment of depressed psychiatric patients.


Loxapine: a controlled evaluation in chronic schizophrenic patients.


Pimozide in the treatment of chronic schizophrenic patients.


Fluspirilene in the treatment of chronic schizophrenic patients.


Clinical evaluation of mazindol in chronic schizophrenics.


Comparison of theophylline blood levels: tablet vs. liquids.


The effect of treatment on obesity. A follow-up investigation of a material treated with complete starvation.


An improved one-dimensional thin-layer chromatographic separation of neutral lipid classes.


The influence of pH in buffered reversed-phase thin-layer chromatography of penicillins and cephalosporins.


Two Bence Jones proteins in a macroglobulinaemic patient.


The concentration of prealbumin in human fetal and infant sera.


The Mm. prevertebrale in Formosan monkey.


Treatment of acute maxillary sinusitis. A comparison of four different methods.


Implications of the Vietnam war for tuberculosis in the United States.


Factors influencing the establishment of the neonatal bacterial flora. I. The role of host factors.


Respiratory system flow resistance with digital computer techniques. Measured in cynomolgus monkeys and guinea pigs.


Lymphocytic choriomeningitis in the mouse. 3. Comparative titrations of virus strains in inbred mice.


Plaque formation of rubella virus in clones of SIRC cells.


Differences between phage infection and transfection in Bacillus subtilis.


The haemagglutinin of ecbovirus SA 1. (Brief report).


Mutations of Anacystis nidulans that affect cell division.


Identification and analysis of a lipopolysaccharide in cell walls of the blue-green alga Anacystis nidulans.


Virulence of Pseudomonas infection in burned rats and mice. Comparative efficacy of silver sulfadiazine and mafenide.


A note on the problem of retinal projections to the inferior pulvinar nucleus of primates.


Neurofibromatosis of bladder: case report and review of literature.


Metabolic fate of mineral oil adjuvants using 14C-labeled tracers. I. Mineral oil.


Metabolic fate of mineral oil adjuvants using 14C-labeled tracers. II. Mannide monooleate.


Anhydrotetracycline and 4-epianhydrotetracycline in market tetracyclines and aged tetracycline products.


Mutation of growth of leptospires in Shenberg's medium.


Antimicrobial activity of some beta-nitrostyrenes.


Bursa of Fabricius containing virus-like particles. An electron microscopic observation.


A long-term epizootiological study of chicken salmonellosis on a farm with reference to elimination of paratyphoid infection by cloacal swab culture test.


Sheep, minks, savages and presenile dementia. The story of slow viruses.


Carcinoma in epiphrenic diverticula.

Carcinoma in epiphrenic diverticula.


Relative sensitivity of various areas of the retina to laser radiation.


Increased blood supply of the heart muscle after sustained action-nitroglycerin.


Projection fibers from the main sensory trigeminal nucleus and the supratrigeminal region.


Differential metabolism of RNA in neuronal-enriched and glial-enriched fractions of rat cerebrum.


Direction of blood flow in the primate cervical spinal cord.


Electrical impedance of the pituitary gland.


Tobacco and health. Report of Scottsdale Research Conference.


Use of rare and threatened species of nonhuman primates as subjects in biomedical research.


Renal amino acid reabsorption in hyperphenylalaninemic monkeys infused with beta-2-thienylalanine.


The use of carrageenan as a granuloma-producing agent in Freund's adjuvant.


Serum tocopherol measurement: effect of unsuspected impurities in water.


Thymidine kinase activity and DNA synthesis in cells infected with the parvovirus, H-1.


Detection of the heterozygous state in bovine porphyria: analysis of urinary coproporphyrin isomers.


Evaluation of effects of bursa Fabricius extracts on development of immunocompetence in neonatally bursectomized cockerels.


The generalized Shwartzman phenomenon in rabbits with denervated kidneys.


Quantification of individual proteins by immunodiffusion.


Esophageal leiomyoma associated with an epiphrenic diverticulum and hiatus hernia.


Number of Purkinje cells in patients with grand-mal epilepsy treated with diphenylhydantoin.


Electro-convulsive therapy in the treatment of bizarre psychogenic movements.


Morphological studies on transmissible feline fibrosarcoma.


Transfer RNA patterns in livers of rats fed diets containing 3'-methyl-4-dimethylaminoazobenzene.


A note on the harvesting of large numbers of Trypanosoma cruzi blood forms in adult dogs.


Pulmonary clearance of Pseudomonas aeruginosa.


Healing after anterior maxillary osteotomy.


An examination of antibiotic prophylaxis in oral and maxillofacial surgery.


Quantitative histological study of the medial thickness of the pulmonary trunk and muscular pulmonary arteries in the vervet monkey.


Experimental allergic asthma in guinea pigs.


The relative frequency of the Hurler and Hunter syndromes.


Technic of parenteral nutrition.

Technic of parenteral nutrition.


Babesiosis in a Massachusetts resident.

Babesiosis in a Massachusetts resident.


Parasites disentangled.

Parasites disentangled.


The present status and future of megavoltage radiation therapy.


Biochemistry of cell and virus multiplications.


Hodgkin's disease clinical trial.

Hodgkin's disease clinical trial.


Experimental hypertensive retinopathy in the monkey.


Fluorescence angiography.

Fluorescence angiography.


A technique of keratoplasty for aphakic bullous keratopathy.


Congenital colobomata of the lids.

Congenital colobomata of the lids.


Trabeculectomy "ab externo".

Trabeculectomy "ab externo".


Is history alone sufficient for the diagnosis of coronary artery disease?


Distribution and disappearance rates of infused cortisol on acute hyper- and hypocalcemic dogs.


Foot-and-mouth disease: the agar gel diffusion precipitin test for antibody to virus-infection-associated (via) antigen as a tool for epizootiologic surveys.


The determination of traces of beryllium in human and rat urine samples by gas chromatography.


Sensitivity of hospital strains of Ps. aeruginosa to sulfamylon acetate.


Intrapleural chemotherapy for effusion from metastatic breast carcinoma.


Systemic chemotherapy for advanced breast cancer.


2,2'-(9,10-anthrylenedimethylene)bis[2-thiopseudourea], dihydrochloride, dihydrate (NSC-56054)--clinical brochure.


Dibromodulcitol (NSC-104800)--clinical brochure.


Cytosine arabinoside (NSC-63878)--clinical brochure.


5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide (NSC-82196)--clinical brochure.


Porfiromycin (NSC-56410)--clinical brochure.


The distribution of serum albumin in the diseased human nephron as demonstrated by immunofluorescence.


Formation of spore-specific DNA photoproducts in UV-irradiated bacterial spore-spheroplasts but not in ruptured spheroplasts.


Optical isomers of miscellaneous strong analgetics.


Tibial dyschondroplasia in the fowl.

Tibial dyschondroplasia in the fowl.


Aflatoxins and liver injury in the rhesus monkey.


Epidermal growth factor: high and low molecular weight forms. In crude homogenates of the submaxillary gland of the male mouse, epidermal growth factor (EGF) activity was found almost entirely in a high molecular weight complex (about 74,000 daltons). This high molecular weight form may be reversibly dissociated into EGF and an EGF-binding protein. EGF was found to have a molecular weight of approximately 6400. The EGF-binding protein has a molecular weight of 29,000, and shows arginyl-esterase activity.


Toxic substances and the nervous system.


Regulation of cerebral circulation.

Regulation of cerebral circulation.


The surgical significance of six anomalies of the biliary duct system.


Haemophilus influenzae in cultures of cerebrospinal fluid. Noncapsulated variants typable by immunofluorescence.


The nevus sebaceous of Jadassohn. A neurocutaneous syndrome and a potentially premalignant lesion.


Pseudomonas aeruginosa: serogroups and antibody response in patients with neoplastic diseases.


The influence of uterine blood flow on the acid-base status of the rhesus monkey.


Postoperative radiotherapy in the treatment of breast cancer: results of the NSABP clinical trial.


Mandelic acid racemase from Pseudomonas putida. Purification and properties of the enzyme.


Distribution of commissural axon terminals in the rat neocortex.


Immunochemical distinction between the Escherichia coli polypeptide chain elongation factors Tu and Ts.


Phosphorylation of ribosomal proteins in rabbit reticulocytes. Characterization and regulatory aspects.


Cutaneous reflexes and pathways affecting them in the monkey, Macaca mulatta.


Increases in auditory middle frequency discrimination thresholds after cortical ablations.


Different effects of temporal lobe lesions on learning of visual pattern discriminations and of a visuomotor coordination task.


The binding of 4-hydroxy-3-nitrobenzenesulfonamide, a reporter group labeled inhibitor, to carbonic anhydrases.


Metabolic effects of ethacrynic acid in the aged.


Bactericidal properties of Tego 103 S and Tego 103 G. The bactericidal activity of Tego 103S was compared with that of chlorhexidine in ethanol, and Tego 103G with Halamid. The activity was determined on Pseudomonas aeruginosa, Staphylococcus aureus and Achromobacter anitratus by various methods. Tego 103S in 1% solution was less active than chlorhexidine 0.5% in 70% ethanol, and Tego 103G in 1% solution was less active than Halamid 0.3%. The presence of serum did not noticeably influence the activity of the Tego preparations.


Studies on the serological relationships between avian pox, sheep pox, goat pox and vaccinia viruses. By using neutralization, complement fixation and immunogel-diffusion tests, it has been demonstrated that cross-reactions occur between various avian pox viruses and between sheep pox and goat pox viruses. No such reactions were demonstrated between avian pox viruses and vaccinia virus or between avian pox and sheep pox and goat pox viruses. Furthermore, no serological relationship was demonstrable between vaccinia virus and sheep pox and goat pox viruses.


The extracellular antigens of Micropolyspora faeni: their significance in farmer's lung disease. A serological analysis of the extracellular antigens of Micropolyspora faeni by immunodiffusion with a combination of sera revealed 29 individual antigens. A survey was made of the incidence of precipitins to the antigens in sera from patients with clinical farmer's lung disease (FLD) and other respiratory diseases. Precipitating antibody was found in 75% of farmer's lung cases and in 20% of other cases who had been exposed to the same environment. More precipitin reactions were seen in sera from severe forms of FLD than from milder forms. The distribution of precipitins to individual antigens was not significantly affected by severity of disease.Most of the patients with precipitins to M. faeni, but without the symptoms of FLD, were suffering from mild or moderate symptoms of other respiratory diseases with a history of chronic onset of symptoms. The distribution of precipitins to individual antigens in this group was similar to that in clinical FLD patients but the incidence was considerably lower.The significance of these results is discussed.


Antigenic differences within the species Mycoplasma hominis. Membrane and soluble fractions of one genital and two oral strains of Mycoplasma hominis were compared by immunodiffusion and polyacrylamide gel electrophoresis. Differences were demonstrated between the membrane antigens of the three strains by immunodiffusion, and the membrane proteins also gave dissimilar patterns in polyacrylamide gel electrophoresis. The soluble fractions gave identical lines in immunodiffusion tests and similar patterns in polyacrylamide gel electrophoresis.When the strains were cross-titrated in metabolic inhibition (MI) and indirect haemagglutination (IHA) tests, statistical analysis of the results revealed significant differences between the strains. Previously, growth-inhibition, MI and IHA activity was shown to be associated with the membrane antigens of M. hominis, so the intraspecies differences revealed by MI and IHA correlate with the differences in the membrane antigens demonstrated by immunodiffusion. Growth-inhibition tests, which might also have been expected to show intraspecies differences, did not do so, probably because of the insensitivity of the test. In contrast to MI and IHA, complement-fixation (CF) tests revealed a high degree of relatedness between the strains. This is consistent with the observation that the soluble antigens of M. hominis participate in the CF reaction, and that the soluble antigens of different strains are identical in immunodiffusion tests.


Veins of the spinal cord. Anatomic details; suggested clinical applications.


Angiographic changes in focal motor epilepsy.


Looking to see: some experiments on the brain mechanisms of attention in perception.


Eye catching in adults, children and monkeys: some experiments on orienting and observing responses.


Treatment of lateral ligamentous injuries of the ankle.


Double-blind study comparing the intramuscular usage of an acridan derivative, SK&F 14336, to chlorpromazine.


A pilot study of AHR-1900 in chronc schizophrenic patients.


Case study; paratyphoid B.

Case study; paratyphoid B.


The arrangement of the axonemal microtubules and links of Echinosphaerium nucleofilum.


N-substituted N'-hydroxythioureas.

N-substituted N'-hydroxythioureas.


Substituted N-phenylanthranilic acid hydrazides as potential antimalarial and antimirobial agents.


Action of toyocamycin on nucleolar fine structure and function.


Chronic paranoid schizophrenia complicated by epilepsy.


The effect of a Class II intermaxillary force on the dentofacial complex in the adult Macaca mulatta monkey.


Synthesis and properties of a protoplast-bursting factor from Bacillus amyloliquefaciens.


Experimental studies on carbonic anhydrase activity in the gastric mucosa and on the fine structure of the parietal cell.


A comparative review of the results of neuropsychological research on man and monkey.


The binding of 1-triiodothyronine to plasma proteins. Cross-linked high molecular polysaccharide sorption of 1-triiodothyronine as a method of evaluating a clinical T3-test and to characterize 1-triiodothyronine-protein binding.


Ossification of semilunar cartilage. Report of a case.


Long-stay psychiatric hostels run by private enterprise in South Australia.


Experimental tuberculosis of the central nervous system.


The intracavitary irradiation of carcinoma of the cervix uteri, using a linear distribution of sources.


Insect bites in white and Negro children: a comparison.


Antigenic relationship of various house dust antigens.


Studies on the Bacillus subtilis neutral-protease- and Bacillus thermoproteolyticus thermolysin-catalyzed hydrolysis of dipeptide substrates.


Characterization and partial purification of a lipase from Pseudomonas aeruginosa.


Immunochemical relationships of chicken pepsinogens and pepsins.


The purification and properties of oxidized derivatives of L-histidine ammonia-lyase.


[Synthesis of 3,4-dihydro-3-amino-7-hydroxycoumarin from S-methyl-l-cysteine and resorcinol by crystalline-beta-tyrosinase].


A functional tyrosyl residue in arginine kinase, studied by nitration with tetranitromethane.


Recent clinical and experimental results concerning vestibular and oculomotor mechanisms.


Matchamycin: a new antibiotic produced by Streptomyces E-753.


Biochemical studies on gentamicin resistance.


Purification and properties of glycerol dehydrase.


Automated blood group serology.

Automated blood group serology.


Physical and chemical changes in isolated chylomicrons: prevention by EDTA. When washed chylomicrons obtained from the lymph of rats, which had been fed corn oil, were maintained at 0-4 degrees C in 0.9% NaCl, the following physical and chemical changes were observed to occur: increased polarity of chylomicron lipids, increased ultraviolet absorption of chylomicron lipids at 232 nm, decreased linoleic acid content, and aggregation. These alterations occurred more rapidly at room temperature and were found to be associated with an increased lipid peroxide content. The behavior of isolated olive oil chylomicrons was qualitatively similar. All observed changes in the properties of washed chylomicrons were prevented by 0.25 mm EDTA; when tested, 25 micro m EDTA was equally effective. The changes were also prevented by 0.02% hydroquinone. The alterations in chylomicron lipids appear to result from the autoxidation of esterified linoleic acid. Studies with linoleic acid-U-(14)C-labeled chylomicrons indicated that cleavage of the linoleic acid carbon chain did not accompany the physicochemical changes. These results demonstrate the usefulness of EDTA in preventing these specific and progressive alterations in chylomicrons dispersed in aqueous systems.


Primate grooming as a tension reduction mechanism.


Hepatitis-associated antigen in blood donor populations. Relationship to posttransfusion hepatitis.


Giant cell formation in lymphoid tissues of monkeys inoculated with various strains of measles virus.


Studies of the serum therapy of type E botulism. 3.


Protein constituents in exudates of delayed hypersensitivity skin lesions.


Enhancement by tetrahydrouridine of 1-beta-D-arabinofuranosylcytosine (cytarabine) oral activity in L1210 leukemic mice.


Electron density studies on quinoline analogs of N, N'-dimethyl-p-phenylazoaniline.


Cyclophosphamide regimens in rhesus monkey with and without marrow infusion.


Degeneration of the cardiac nerves in Chagas' disease. Further studies.


Therapy of angina pectoris with propranolol and long-acting nitrates.


Observations on circular and longitudinal gingival collagen fibres in the rhesus monkey.


Studies on the mucogingival junction.

Studies on the mucogingival junction.


Sodium and potassium levels in Blepharisma Intermedium.


Whole body sterol metabolism in squirrel monkeys (Saimiri sciureus).


Laboratory anticoccidial evaluation trials: review of designs, variables, criteria, and predictive value for field use.


Carbon monoxide-aggravated atherosclerosis in the squirrel monkey.


Diseases which can and should be detected early.


Complications of total hip replacement.

Complications of total hip replacement.


Insulin allergy and insulin resistance. Case report with immunologic studies.


An animal model of a hypersensitivity pneumonitis.


Allergic bronchopulmonary aspergillosis: characterization of antibodies and results of treatment.


Role of surface-active agents in drug absorption.


Pressure-volume curves of air- and liquid-filled excised lungs-surface tension in situ.


Effect of hypothalamic temperature waveforms on peripheral blood flow in the baboon.


Carbenicillin: how useful?

Carbenicillin: how useful?


Factors influencing the metabolic actions of catecholamines.


In-vitro activity of carbenicillin and results of treatment of infections due to Pseudomonas with carbenicillin singly and in combination with gentamicin.


Intravenous administration of carbenicillin for septicemia due to Pseudomonas aeruginosa following thermal injury.


Use of carbenicillin in patients with cystic fibrosis.


Clinical and microbiologic studies of carbenicillin.


A study of the mechanism of action and role of a natural inhibitor of dopa autoxidation isolated from guinea pig skin.


Isolation and partial characterization of the natural inhibitor of dopa autoxidation in skin.


A method for evaluating sunscreen protection from longwave ultraviolet.


A case of listeriosis of the newborn.

A case of listeriosis of the newborn.


Catecholamines in epidermis, dermis and whole skin.


Ultrastructural cytochemistry of Bacillus subtilis.


Diverticulum of the female urethra: clinical aspects and presentation of a simple operative technique for cure.


Temperature-sensitive steps in the biosynthesis of Venezuelan equine encephalitis virus. In contrast to Eastern equine encephalitis virus, the replication of Venezuelan equine encephalitis (VEE) virus was strongly inhibited at 44 C in chick embryo cells. The inhibited steps were analyzed by shifting the incubating temperatures up or down, and by determining during the shifts the rate and extent of infectious ribonucleic acid (RNA) synthesis, intact virus synthesis, and formation of complement-fixing antigen or of antigen detectable by a direct fluorescent-antibody technique. The inhibition appeared to be due to two temperature-sensitive steps involved in the synthesis of VEE virus in chick embryo cells. The first step of inhibition at 44 C occurred early in virus replication and could be completely reversed simply by transferring cultures to 37 C. The inhibition appeared to take place at some point between the time when the virus entered the cell and was uncoated and the beginning of viral RNA synthesis. The second temperature-sensitive step in VEE virus synthesis was irreversible; it occurred at a point after the synthesis of viral RNA, and before the formation of virus protein measured as complement-fixing antigen or as antigen that could be stained with fluorescent antibody.


Effect of polyions on the infectivity of rabies virus in tissue culture: construction of a single-cycle growth curve. The infectivity of fixed rabies virus in a number of cell lines has been shown to be markedly enhanced by the addition of protamine or diethylaminoethyl dextran to the virus inoculum. The polycations appear to exert their influence at a very early stage (adsorption or penetration or both) of virus-cell interaction. Immune globulin blocked infection completely when added up to 5 min after exposure and almost completely when added 5 to 15 min after infection. Antibody had no effect on adsorption and penetration when added to the inoculum 30 min or more after cells were exposed to the virus. Irradiation of BHK/21 cell monolayers with ultraviolet light increased their sensitivity to rabies virus. The events occurring after synchronous infection of cells in both irradiated and nonirradiated cell monolayers were followed by means of fluorescent-antibody staining and by intracerebral titration in mice. Virus-specific fluorescent antigen first appeared between 8 and 9 hr after infection, and in irradiated cultures there was a further lag period of 3 hr before infectious virus was produced intracellularly. Virus was first detected in the medium 12 to 15 hr after infection, and maximal yield of infectious virus was observed 48 hr after exposure. In nonirradiated cultures, formation of infectious virus was delayed, and the final yield of virus was also reduced.


Physical assay and growth cycle studies of a defective adeno-satellite virus. Electron microscopic particle counting of the defective adeno-satellite virus (ASV), by use of pseudoreplication and negative staining with phosphotungstic acid, was shown to be a reproducible quantitative assay procedure. Particles of satellite type 4 that were counted in fluids from infected cultures had the same morphology as particles that banded at a buoyant density of 1.43 g/cc in cesium chloride. Other satellite virus serotypes examined in the same manner had a buoyant density of 1.37 to 1.38 g/cc. A comparison of satellite titers obtained by complement fixation and by particle counting demonstrated that an increase in satellite particles resulted in a corresponding increase in CF titers; however, electron microscopy was at least 10 times more sensitive than complement fixation for detecting satellite virus. Growth cycle studies of satellite virus in cells co-infected with adenovirus, as assayed by particle counting, indicated that the kinetics of satellite virus production closely followed the kinetics of its helper adenovirus production, with an eclipse period of 12 to 16 hr. The eclipse period of the satellite remained the same when cultures were preinfected with satellite 24 hr prior to adenovirus inoculation. However, when cultures were infected with adenovirus 12 hr before satellite virus, the eclipse period of the satellite was shortened to between 4 and 6 hr. Thus, satellite virus replication seems dependent upon a relatively late event in the adenovirus replication cycle. When cells were co-infected with adenovirus and its defective satellite, the yield of adenovirus was markedly reduced from that obtained in cells singly infected with adenovirus.