Attempt on determination of biologically active lead in organism in experimental poisoning.


Incidence of antiprotozoal and antivermal antibiotics in fungi. II. Class Oomycetes.


Incidence of antiprotozoal and antivermal antibiotics in fungi. I. Class Fungi imperfecti.


Incidence of antiprotozoal and antivermal antibiotics in fungi. 3. Genus Penicillium.


Listeria monocytogenes meningitis in an adult Nigerian female.


Thyroxine binding proteins of human serum at physiological pH.


Thyroxine binding proteins of mouse serum at physiological pH.


Atrial specific granules in various mammals.


The effect of propranolol in the long-term treatment of angina pectoris.


Propranolol in angina pectoris.

Propranolol in angina pectoris.


Jaundice associated with bacteremia.

Jaundice associated with bacteremia.


Thiobarbituric acid test as an index of phospholipid peroxidation.


Serum amylase as a measure of salivary gland radiation damage. Hyperamylasaemia following fractionated exposure to 4 MV X rays delivered in high pressure oxygen, and effects of certain steroids on this response.


Protection of the eye in megavoltage radiotherapy.


Californium 252 as an external source of neutrons for radiotherapy treatment.


Maternal Rh immunization.

Maternal Rh immunization.


Hazard of self-inflating resuscitation bags.


Comparison of trifluperidol, trifluoperazine and chlorpromazine in preschool schizophrenic children: the value of less sedative antipsychotic agents.


Prazepam in the treatment of psychoneurotic outpatients: a brief report.


Clinical trial with thiothixene parenteral in agitated schizophrenic patients.


Preliminary report of a longitudinal study of the effects of lithium on iodine metabolism.


Hydergine for treatment of symptoms of cerebrovascular insufficiency.


Carica papaya as ancillary therapy for athletic injuries.


Anti-inflammatory effect of AHR-1911.

Anti-inflammatory effect of AHR-1911.


Tetracycline and renal tubular function.


The galactose binding protein and its relationship to the beta-methylgalactoside permease from Escherichia coli.


Multiple combination therapy in cancer chemotherapy in Japan.


Antibiotic MSD-819. Preparation and properties of biologically active derivatives.


Glaucoma therapy simplified.

Glaucoma therapy simplified.


Trisomy D1 (13-15) associated with XO-XY mosaicism.


Genetic control of gamma chain synthesis: a chemical and evolutionary study of the Gm(a)factor of immunoglobulins.


Model catalysts which simulate penicillinase. IV. Steric and electronic effects in the catalysis of hydrolysis of penicillins and cephalothin by aminoalkylcatechols.


Kinetic analysis of penicilloic acid and penicilloamides in combinattion: application to products of reaction of penicillin with tromethamine (tris) and poly-L-lysine.


Aggression and epilepsy rage in children with temporal lobe epilepsy.


The short-term effects of chondroitin sulfates A and C on coronary atherosclerotic subjects: With reference to its anti-thrombogenic activities.


Psychopharmacological aspects of aggression: a review of the literature and some new experiments.


Serologic survey with the sera of monkeys in regard to their natural infection with measles virus.


Cross immunity of mouse mononuclear phagocytes induced by immunization and by transfer agent.


Lysosomes in tuberculous infection.

Lysosomes in tuberculous infection.


Application of the spot method to the quantitative assay of anti-bacterial antibody to several bacterial genera.


Hepatomegaly and allergic responses in helminthic infections transmitted from animals.


Post mortem studies of systemic candidiasis: I. Diagnostic validity of precipitin reaction and probable origin of sensitization to cytoplasmic candidal antigens.


Principles for the testing and evaluation of drugs for carcinogenicity. Report of a WHO scientific group.


Specifications for the identity and purity of food additives and their toxicological evaluation: some antibiotics. Twelfth report of the Joint FAO-WHO Expert Committee on Food Additives. Geneva, 1-8 July 1968.


Characteristics of 45Ca binding in vascular smooth muscle.


A method for preparation of experimental autologous cerebral emboli.


A thermolabile direct hemolysin of Vibrio parahaemolyticus.


A common antigenic substance of Vibrio parahaemolyticus. I. Isolation and purification.


Immunochemical studies on O-antigens of Vibrio parahaemolyticus. 1. Preparation, specificity and chemical nature of the antigens.


Discovery of modification of the synthetic tripeptide-sequence of the thyrotropin releasing hormone having activity.


Germination-induced repair of single-strand breaks of DNA in irradiated Bacillus subtilis spores.


An enzyme system for aliphatic methyl ketone oxidation.


Pig liver esterase. Physical properties.


Partial sequences of six macroglobulin light chains. Absence of sequence correlates to functional activity.


Studies on a lipopolysaccharide from Escherichia coli. Heterogeneity and mechanism of reversible inactivation by sodium deoxycholate.


Adjunctive antibacterial instillation in radiotherapy of carcinoma of the bladder.


Gonococcal salpingitis.

Gonococcal salpingitis.


Sensitivity of Neisseria gonorrhoeae to penicillin and other antibiotics. Studies carried out in Toronto during the period 1961 to 1968.


Relationships between the sensitivities in vitro of Neisseria gonorrhoeae to spiramycin, penicillin, streptomycin, tetracycline, and erythromycin.


Gonococcal ulceration of the tongue in the gonococcal dermatitis syndrome.


Partial characterization of an antigen in spontaneous murine mammary tumors.


A primate corral.

A primate corral.


Adrenalectomy of the rhesus monkey (Macaca mulatta): anatomy and surgical technique.


Acute pyometra in a rhesus monkey (Macaca mulatta).


Pneumococcal meningitis and peritonitis in rhesus monkeys.


Systemic cryptococcosis in 2 monkeys.

Systemic cryptococcosis in 2 monkeys.


Melioidosis with spontaneous remission of osteomyelitis in a macaque (Macaca nemestrina).


Pulmonary nocardiosis in a vervet monkey.


An epizootic of shigellosis in a monkey colony.


Atypical fatal pulmonary botryomycosis in two guinea pigs due to Pseudomonas aeruginosa.


A mite infestation in squirrel monkeys (Saimiri sciureus).


An ameloblastic odontoma in a cebus monkey (Cebus albifrons).


Acute bloat syndrome (gastric dilatation) in Macaca mulatta.


Segmental hypertrophy of the colon in a rhesus monkey.


The nephrotic syndrome associated with glomerulonephritis in a rhesus monkey (Macaca mulatta).


Coenurosis in a gelada baboon (Theropithecus gelada).


Denamycin, a new antibiotic.

Denamycin, a new antibiotic.


Stdies on streptomycetes. Lateriomycins A and B, new antitumor and antibacterial antibiotics produced by Streptomyces griseoruber, strain No. 71070.


Attempted isolation of hepatitis viruses in marmosets.


Shigellosis in cynomolgus monkeys (Macaca irus). VII. Experimental production of dysentery with a relatively small dose of Shigella flexneri 2a in ascorbic acid deficient monkeys.


The postpartum menstruation of cynomolgus monkeys kept under the laboratory conditions.


Regulation of serum thyroxine values.

Regulation of serum thyroxine values.


Febrile illnesses in the tropics (Vietnam).


Catino D: Investigations on acute febrile illness in American servicemen in the Mekong Delta of Vietnam.


Surgical research in the United States Army (Japan, Communication Zone) II.


Leprosy in the military services.

Leprosy in the military services.


In vitro susceptibility of Neisseria gonorrhoeae to different antibiotics.


Scleroderma and amyloidosis.

Scleroderma and amyloidosis.


An incidence study of military personnel engaging in suicidal behavior.


A case of Gilles de la Tourette's disease on active military duty.


Association between chloramphenicol, hypoplastic anemia and acute myeloblastic leukemia: a case report.


Field medical problem.

Field medical problem.


Analytic indication of the impracticability of incapacitating an attacking shark by exposure to waterborne drugs.


Why "military" medicine?

Why "military" medicine?


On smoking and the uses of adversity.

On smoking and the uses of adversity.


Partial thyroxine-binding globulin deficiency in a family.


Thyroid function in the term fetus.

Thyroid function in the term fetus.


An electron microscopic study of non-phagocytic reticulum cells in human bone marrow. I. Cells with intracytoplasmic fibrils.


Histochemical demonstration of nonspecific esterase on the secretion of goblet cells in the guinea pig's small intestine.


The electroretinogram of juvenile patients with retinal detachment.


Juvenile retinal detachment.

Juvenile retinal detachment.


Experimental retinal detachment and reattachment: I. Methods, clinical picture and histology.


Experimental retinal detachment and reattachment: II. Electron microscopy.


The original haemorrhagic fever: yellow fever.


Antilymphocytic serum.

Antilymphocytic serum.


Effects of dietary methionine and vitamin B12 deficiency on folate metabolism.


Simulated subarachnoid haemorrhage in monkeys under pentobarbital-halothane anaesthesia, with particular reference to monitoring during cerebral angiography.


Distribution of diamine oxidase and imidazole-N-methyltransferase along the gastrointestinal tract.


Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV x-rays. I. Effects of single exposures.


Inhibition of carbonic anhydrase by mercaptans.


The "golden" mulatta macaque (Macaca mulatta): developmental and reproduction characteristics in a controlled laboratory environment.


Adrenal cortical rests of the ovarian hilus of the patas monkey.


Communication during initial contact: a comparison of squirrel and rhesus monkeys.


Pathogenesis of oncogenic simian adenoviruses. IV. The histopathology and ultrastructure of intraperitoneal neoplasms induced by SV20.


Electron microscopic demonstration of carbonic anhydrase activity in mouse liver cells.


Regulation of purine ribonucleotide synthesis by end product inhibition. II. Effect of purine nucleotides on phosphoribosylpyrophosphate amidotransferase of Bacillus subtilis.


Kinetics and mechanism of transfer action of saccharifying alpha-amylase of Bacillus subtilis. Maltose--phenyl alpha-glucoside system.


Studies on chemically modified cytochrome c. 3. The 22-acetyl-cytochrome c.


The development and treatment of deformity in pseudoachondroplastic dwarfs.


Preparation of acylated protein from rat liver mitochondria.


What about medical care cost?

What about medical care cost?


Bradykinin in cerebral angiography. Experimental observations in monkeys.


Immunoelectrophoretic-chemical investigation of erythrocyte aspartate aminotransferase.


Immunological studies on plasma proteins excreted in the normal human urine.


Separation of SK-plasminogen-complex in sera and euglobulin solution of cat and monkey by gel filtration using sephadex G-200.


Immunological specificites of polysaccharides and proteins from Salmonellae of group C.


Size constancy in monkeys with inferotemporal lesions.


Cellular organization in the subodontoblastic zone of the dental pulp. I. A study of cell-free and cell-rich layers in pulps of adult rat and deciduous monkey teeth.


Dextranase and dental caries.

Dextranase and dental caries.


Pharmacology for the dental practitioner. 7. Systemic disease and dental practice (continued).


Midgets, dwarfs and their fickle lot.

Midgets, dwarfs and their fickle lot.


The micro-slide gel double diffusion test for the detection and assay of staphylococcal enterotoxins.


Intersociety committee methods for ambient air sampling and analysis: Tentative method of analysis for sulfur dioxide content of the atmosphere (colorimetric) 42401-01-69T.


Effect of inferotemporal lesions upon processing of visual information in monkeys.


Motivation, regulation, and the control of meal parameters with oral and intragastric feeding.


Hepatic schistosomiasis as a research model.


Loss of potency in male rhesus monkeys when paired with females receiving contraceptive steroids.


Serological reactions of bovine diarrhoea viruses with anticellular and antivirus sera produced in rabbits.


Characterization of lytic bacteriophages of Bacillus thuringiensis.


Characterization of temperate bacteriophages of Bacillus thuringiensis.


Studies on human gastric intrinsic factor. 3. Immunological observations of vitamin B12 binders in human gastric juice and other body fluids.


An increased sensitivity to alcohol in rabbits treated with a certain factor contained in a microsomal subfraction of the brain.


The report of the Director-General of Health.


The fetus and the newborn.

The fetus and the newborn.


Interspecies comparison of drug effects in primates.


Pre-clinical drug evaluation and method development.


Polynucleotide sequence analysis by sequential base elimination: 3'-terminus of phage Q-beta RNA. The nucleotide sequence of a 3'-terminal fragment obtained by ribonuclease T(1) hydrolysis of the ribonucleic acid from bacteriophage Qbeta has been determined by an improved method of sequence analysis which involves sequential removal of bases by periodate oxidation and beta-elimination. The results obtained from ten such oxidation-elimination cycles and from the alkaline hydrolysis of the remaining oligonucleotide indicate that the first 16 nucleotides at the 3'-terminus of this ribonucleic acid have the sequence: -G-C-C-C-U-C-U-C-U-C-C-U-C-C-C-A.


Feline leukemia virus: occurrence of viral antigen in the tissues of cats with lymphosarcoma and other diseases. Felinie leutkemia viruts antigen is demonstrable by immunodiffusion with rabbit precipitating antiserum to purified felinie leukemia virus. The felinie leukemia virus antigen was found in the tissues of 25 of 33 cats with lymphosarcoma and of 5 of 13 cats with infectious peritonitis. Its presence was correlated with the occurrence of felinie leukemia virus demonstrable by electron microscopy. The one clinically normal cat giving a positive test for feline leukemia virus antigen belonged to a household in which two cats had developed lymphosarcoma. With the exception of a dog with lymphosarcoma induced by feline leukemia virus, the antigent was absent from lymphosarcoma and nonlymphomatous tumors of other species (man, dog, cow, goat, or pig).


Response to treatment with isoniazid plus PAS of tuberculous patients with primary isoniazid resistance.


Rifampicin in daily and intermittent treatment of experimental murine tuberculosis, with emphasis on late results.


Rifampicin in treatment of experimental tuberculosis in mice.


A sputum swab culture method for tubercle bacilli using cetrimide compared with two other swab culture methods and the concentration culture method.


Characteristic changes in Mycobacterium tuberculosis induced by some tensides (surface-active agents).


The changing pattern of Neisseria Meningitidis 1966-1969.


Right atrial and pulmonary artery pressure as indicators of left atrial pressure during fluid therapy following hemorrhagic shock in the baboon.


Rate of recovery from acute hypocalcemia as a measure of calcium homeostatic efficiency in the dog.


Effect of lipid and ketone infusions on insulin-induced growth hormone elevations in rhesus monkeys.


In vitro response of the rat pituitary to gonadotrophin-releasing factors and to ions.


Stimulation of DNA synthesis in cartilage of hypophysectomized rats by native and modified placental lactogen and anabolic hormones.


Effect of a carbonic anhydrase inhibitor (Diamox) on the progesterone-stimulated rabbit uterus.


Nucleolar and mitotic abnormalities produced by thioacetamide and hydroxylamine in monkey kidney cells cultivated in vitro.


The effect of chronic alcohol adminstration on the immune responsiveness of rats.


Antigenic relation between house dust and a dust mite, Dermatophagoides farinae Hughes, 1961, by a fractionation method.


Effects of variations of thyroxine-binding globulin capacity on the disappearance of triiodothyronine from the plasma.


The immunogenicity of dinitrophenyl amino acids. Numerous dinitrophenyl amino acid preparations injected intradermally induced contact hypersensitivity to dinitrochlorobenzene, delayed type skin reactions to DNP-amino acids, and anti-DNP antibodies in guinea pigs. Some DNP-amino adds induced precipitating anti-DNP antibodies in rabbits as well. Some of the DNP-ammo acids studied were regularly immunogenic, possible immunogenic impurities having been excluded by extensive purification procedures. Others were either constantly nonimmunogenic or irregularly immunogenic, e.g., their immunogenicity varying from one preparation lot to another. By means of extensive chemical analyses and the establishment of dose-response curves, we were able to demonstrate in most cases that the immunogenicity was not due to contamination with unreacted dinitrofluorobenzene or other DNP derivatives, to photodecomposition or other degradation products, or to DNP-protein contaminants. Nevertheless, the irregular immunogenicity of several DNP-amino acid preparations can only be explained by a highly immunogenic impurity (or impurities) which we were unable to detect analytically. The regular immunogenicity of some other DNP-amino acids (e.g. di-DNP-L-histidine) appears to be based on a "transconjugation" phenomenon, the DNP group being able to split off from its amino acid carrier and to conjugate secondarily with proteins in vivo and in vitro. Accordingly, the interpretation of some recent data concerning the immunogenicity of low molecular weight hapten-amino acids may have to be reevaluated.


Binding between components of the tubercle bacillus and humoral antibodies. Studies were undertaken to find a substance or substances for use in primary binding types of tests to detect humoral antibodies in rabbits and monkeys exposed to the tubercle bacillus that would distinguish between strains of mycobacteria. The antigen employed was a component of the 5159 strain of Mycobacterium tuberculosis that was obtained following sonification, ultracentrifugation, electrophoresis, and elution from a preparative polyacrylamide column. When the antigen was labeled with (131)I, specific binding was observed in sera from immunized rabbits and BCG-protected rhesus monkeys by the radio-gel electrophoresis and ammonium sulfate tests. This component was partially characterized, and its major antigenic determinants were associated with anionic mucopolysaccharides. Electrophoretically at pH 8.3 it migrated anodally to albumin, its molecular weight was between 9,000 and 12,000, and it was soluble in 50% saturated ammonium sulfate. Binding to antibody was destroyed after treatment with Pronase, but not after DNase or RNase. Inhibition of the reaction, as measured by the ammonium sulfate test, between the (131)I-labeled component and antisera from rabbits that had been immunized with sonicated 5159 organisms, was studied. These experiments demonstrated a capacity to define subtle similarities and differences among different mycobacteria and mycobacterial components. Some microorganisms not clearly related to mycobacteria also partially inhibited this reaction, suggesting that they shared antigenic groups with the component derived from 5159 organisms. The studies described suggested the advisability of using direct primary tests and purified components of mycobacteria to differentiate further the antigenic groups between individual pathogenic mycobacteria and between pathogenic and nonpathogenic organisms.


Responses of dorsal horn cells of M. mulatta to cutaneous and sural nerve A and C fiber stimuli.


Response of striate cortex neurons to stimuli during rapid eye movements in the monkey.


Comparison of effects of eye movements and stimulus movements on striate cortex neurons of the monkey.


Collection, gross characteristics and freezing of baboon semen.


New methods of treatment for renal allotransplants using the baboon as a primate experimental model.


The significance of the isolated positive urine culture in genitourinary tuberculosis.


Macroglobulinemia associated with subcutaneous tumors: report of two cases.


Some aspects of protein histochemistry in the parathyroid gland of the rabbit.


Physiologic approach to the treatment of angina pectoris.


Virus-like structures in lupus erythematosus.


A rational method of financing health care.


Genetic polymorphism of rhesus thyroxine-binding prealbumin: evidence for tetrameric structure in primates. Polymorphism in primate thyroxine-binding prealbumin was investigated with agarose gel electrophoresis at pH 8.6. In the rhesus monkey (Macaca mulatta), three forms of this protein were found in random sera: a single rapidly migrating band similar to that in human and other primate sera, a single slowly migrating band cathodal to rhesus albumin, and a five-banded form, the most rapid and slowest bands of which corresponded to the other two forms. The frequencies of occurrence of these three forms were consistent with the hypotheses that rhesus prealbumin is under the control of two codominant autosomal alleles, PA(F) and PA(S), and that the protein occurs naturally in serum as a tetramer composed of similar subunits.It was possible, by simple mixing in vitro, to produce five-banded prealbumin patterns from rhesus PA SS serum and rhesus PA FF serum, M. arctoides serum, P. hamadryas serum, and human serum. Thyroxine was bound by all the hybrid molecules produced in this fashion.


Zenker's diverticulum in Japan.

Zenker's diverticulum in Japan.


The corneal endothelium.

The corneal endothelium.


Lipid metabolism in tissue culture cells.


Effect of acute cardiac tamponade on the cardiovascular dynamics.


Anion-binding to liver alcohol dehydrogenase, studied by rate of alkylation.


Gastric secretory response to chronic hypothalamic stimulation in monkeys.


Gastric phycomycosis. Report of a case and review of the literature.


Niacin test for differentiation of Mycobacterium tuberculosis var. hominis from other acid-fast bacilli. X. Clinical and bacteriological examination of the 2 cases with pulmonary tuberculosis which had excreted niacin test negative mycobacterium tuberculosis var. hominis for a long period. I. Clinical observation.


Genetical control of the concentration of ME7 scrapie agent in mouse spleen.


Niacin test for differentiation of Mycobacterium tuberculosis var. hominis from other acid-fast bacilli. XI. Clinical and bacteriological examination of the 2 cases with pulmonary tuberculosis which had excreted niacin test negative mycobacterium tuberculosis var. hominis for a long period. II. Some properties of the acid-fast bacilli detected.


Niacin test for differentiation of Mycobacterium tuberculosis var. hominis from other acid-fast bacilli. XII. Clinical and bacteriological examination of 2 cases with pulmonary tuberculosis which had excreted niacin test negative Mycobacterium tuberculosis var. hominis for a long period. 3. Animal inoculation of the detected acid-fast bacilli.


Reticulum cell sarcoma in a Sykes monkey (Cercopithecus albogularis).


Intrauterine choriocarcinoma in a rhesus monkey.


Clinical and laboratory findings in an epidemic of type 9 ECHO virus meningitis in the Tokushima area, Japan.


Exanthematous disease due to ECHO 5 virus.


Coloboma of eyelid and harelip. A case report.


Experiences about some means of avoiding enucleation for suspected intraocular tumours.


Ultrastructural pathology of an acute fatal enteritis of captive cottontail rabbits. Search for a viral etiologic agent.


The involvement of histamine in malaria.


A reinvestigation of the substrate specificity of pig kidney diamine oxidase.


Open fractures of talus.

Open fractures of talus.


Automation in the blood transfusion laboratory. II. ABO grouping, Rh and Kell typing, antibody screening, and VD testing of blood donations in the autoanalyzer.


A simple method for the preparation of agarose.


Increased intracranial pressure.

Increased intracranial pressure.


Diabetic ketosis: elevated serum glutamic-oxaloacetic transaminase (SGOT) and other findings determined by multi-channel chemical analysis.


Trehalase: induction in Bacillus cereus.


Certain observations on post dysenteric non-ulcerative colitis.


Preliminary observations on the intestinal bacterial flora of wild Rhesus monkeys with special reference to shigellosis, salmonellosis and vibriosis.


Mitochondrial vulnerability and lipid metabolism. Brain and pancreatic mitochondria.


Depression of respiratory activities in the liver mitochondria of diabetic rats and the restorative action of insulin.


The genetic and developmental regulation of hepatic delta-aminolevulinate dehydratase in mice.


Structural and catalytic properties of lobster muscle glycogen phosphorylase.


4HPyran-2,6-dicarboxylate as a substitute for dipicolinate in the spolation of Bacillus megaterium.


Studies of the proteins in human plasma very low density lipoproteins.


Phenogenetics of the eyeless-dominant mutant f Drosophila melanogaster. I. Development of the lethal larvae.


Electrophoretic variations of tyrosinase in follilar melanocytes during the hair growth cycle in mice.


Studies on the selective toxicity. VII. Nematocidal activities of thiol esters.


Permanent care of elderly people in institutions.


Zinc in relation to DNA and RNA synthesis in regenerating rat liver.


Responses to Rh challenge.

Responses to Rh challenge.


Use of maternal blood for intrauterine transfusions.


Posterior subcapsular cataract in children on long term corticoid therapy.


Bone marrow depression in the pelvis after megavoltage irradiation. A study with radioisotope scanning.


Cercopithecoid canine tooth honing mechanisms.


Intrauterine fetal transfusions. Experience with 101 transfusions in 48 mothers.


ltrastructure of meningeal sheaths. Normal human and monkey optic nerves.


Effects of chronic cholinesterase inhibitor treatment. I. The pharmacological and physiological behavior of the anti-ChE-treated monkey (Macaca mulatta) iris.


Penetration of gentamicin. Administered intramuscularly and subconjunctivally into aqueous humor.


Partial Klüver-Bucy syndrome produced by cortical disconnection.


On antigenic differences between nerve cells and glia.


Studies on the stability of drugs in biological media. 2. Relationship between the stability in culture media and anti-bacterial activity of some isoniazid derivatives.


Comparative toxicological, chemotherapeutic and pharmacokinetic studies with sulphormethoxine and other sulphonamides in animals and man.


Hospital utilization and cost trends in Canada and the United States.


Distraction and habituation in monkeys with limbic lesions.


Unilateral frontal lesions and learning by rhesus monkeys.


Lisfranc dislocations.

Lisfranc dislocations.


pH-Partition behavior of tetracyclines.

pH-Partition behavior of tetracyclines.


Biological activity of furanoses. I. Tetrafuranosyl adenines.


Tropical bacterial pyoderma in Vietnam. An improved therapeutic regimen.


Classification and treatment of myoclonus.


Presidential address.

Presidential address.


Delayed incomplete traction palsy of the lateral popliteal nerve.


Protection of burned mice challenged with pseudomonas by peritoneal exudate cells.


Intracellular ribonuclease of Bacillus subtilis; specific inhibition by ATP and dATP.


Carbenicillin resistance in Pseudomonas aeruginosa.


Macromolecular forms of aspartate transcarbamylase in rat liver.


Studies on plasminogen. 8. Species specificity of streptokinase.


Alveolar soft part sarcoma.

Alveolar soft part sarcoma.


Therapeutic irradiation of the chest and electrocardiographic changes.


Duplication of the bacterial cell and its initiation.


Enhancement of fibrinolysis and blood clotting: role of microvascular changes.


Effects of phytic acid and ethylenediaminetetraacetic acid (EDTA) on the chick's requirement for magnesium.


Esophageal atresia. II. Anastomotic disruption following primary surgical management.


The reproductive capacity of rhesus monkeys following x-irradiation of the ovaries.


The velocity of the pulse wave distribution and arterial piesography in adult Hamadryas baboons and rhesus monkeys.


A study of haemolytic disease of the foetus and the newborn occurring in Hamadryas baboons under natural conditions.


Antibodies in nonhuman primate to selected bacterial antigens.


The enhancement of interferon production by endotoxin.


Studies to determine the presence of neutralizing antibody in sera and kidneys from swine recovered from African swine fever.


Attenuation of duck plague virus and its propagation in cell culture.


Restoration of laryngeal function after laryngectomy. Experimental research in animals.


Structural constituents of Venezuelan equine encephalitis virus.


Relationship between chemical structure and platelet-aggregation activity of prostaglandins.


Complement-fixation tests for simultaneous isolation and identification of Dengue viruses, using tissue cultures.


The extractable lipids of Pseudomonas aeruginosa.


The effect of a corrective orthopedic program in severely mentally retarded children.


Biologic effects of heterologous antisera to canine heart.


The specificity of hemagglutinating bean and seed extracts (lectins). Implications for the nature of A-B-H agglutinins.


Relationships between antibodies and experimental allergic encephalomyelitis. I. Production of hemagglutinating and gel-precipitating antibodies in rabbits and guinea pigs.


Pneumoencephalographic changes in Kluver-Bucy syndrome: a case report.


Effects of immunization of baboons with human thyroid tissue.


7S-gamma-1, 7S-gamma-2 and IgM immunoglobulins in the deer mouse (Peromyscus maniculatus).


Model systems for the study of drug hypersensitivity. I. The specificity of the rabbit anti-aspiryl system.


Immunoenzymology of AMP-deaminase.

Immunoenzymology of AMP-deaminase.


Spontaneous thyroiditis in the obese strain of chichens. I. Demonstration of circulating autoantibodies.


Passive cutaneous anaphylactic and Schultz-Dale reactions elicited in guinea pigs by chemically univalent dinitrophenyl-derivatives of bacitracin A and papain.


Effect of 2-mercaptoethanol on 7S rabbit antibodies to various homologous and heterologous antigens.


The binding reactions of antibodies specific for the 2,6-dinitrophenyl group.


Purification of the first component of complement by zonal ultracentrifugation.


Differences in anti-protein A activity among IgG subgroups.


Chagas' disease and chronic chagasic cardiomyopathy in Venezuela.


Coronary heart disease. Hemodynamic response to exercise before and after nitroglycerin.


Cell-culture synthesis of a factor VIII-like activity.


Hereditary blood and serum types, PTC test and level of the fifth fraction of serum lactatedehydrogenase in females with gynecological cancer. I. (Communication).


Hereditary blood and serum types, PTC test and level of the fifth fraction of serum lactatedehydrogenase in females with gynecological cancer. II. (Communication).


Early hospital discharge of patients with active tuberculosis.


Preliminary report. Antigenicity of the mice Ehrlich ascitic tumor cell nuclei.


Suppression of progestational uterine mucosal activity by anthrarufin.


Pharmacological studies on reflex renal vasodilatation.


Susceptibility of mycobacterial D-alanyl-D-alanine synthetase to D-cycloserine.


An autoclavable medium for the isolation of mycobacteria.


Studies on the intestinal flora. II. Bacterial flora of the small intestine in patients with gastrointestinal disorders. The type and distribution of bacteria in the jejunal juice of patients with a variety of gastrointestinal conditions that might affect the small intestinal flora were examined. Bacterial colonization of the jejunum defined, in this context, as the occurrence of a bile salttolerant flora consisting of both aerobic and anaerobic bacteria qualitatively resembling that of faeces, was observed only in patients with some form of blind loop. Prominent among the bacteria isolated from these colonized juices were non-sporing anaerobic bacteria, most usually Bacteroides, able to hydrolyse bile salts. No simple correlation between the patient's fat excretion and bacterial colonization of the jejunum could be demonstrated.


Oesophageal manometric studies in patients with chronic Chagas disease and megacolon. Intraluminal manometric studies performed on 12 patients with chronic Chagas disease and megacolon without clinical or radiological abnormalities of the oesophagus showed no alteration in oesophageal physiology under basal conditions when compared with a control group of 30 healthy subjects. Oesophageal peristalsis was unimpaired. Patients with chronic Chagas disease and megacolon differed from normals in their reaction to a small dose of a cholinergic drug. This agent induced an isolated but significant increase in resting pressure at the level of the oesophagogastric sphincter, accompanied in most cases by an increase in spontaneous activity but not by a change in resting pressure in the body of the oesophagus. This is interpreted as a subclinical expression of oesophageal pathology related to Chagas disease.


The epidemiology of human brucellosis in haryana with regard to 215 strains of brucella isolated from man and animals.


Blood groups and leprosy.

Blood groups and leprosy.


Hematopoietic neoplasms of slaughter animals.


Spontaneous hematopoietic neoplasms of nonhuman primates. Review, case report, and comparative studies.


Canine mast cell diseases.

Canine mast cell diseases.


Comparative aspects of the mastocytoses.


Susceptibility of chickens of different ages to sporozoites of Akiba caulleryi at various doses.


Varsity football. Knee and ankle injury.


Thoracic manifestations of Recklinghausen's disease. Malignant potential.


No excuse for Rh failure.

No excuse for Rh failure.


Elastase activity of Pseudomonas aeruginosa isolates frm hospital patients.


Morphine: conditioned increases in self-administration in rhesus monkeys. Operant responding in three monkeys was maintained by intravenous presentations of morphine. Nalorphine produced reliable increases in morphine-reinforced responding. With successive daily nalorphine injections there was a decreased latency of self-administration responding for morphine, and substituted saline injections produced conditioned increases in morphine-reinforced responding.


Hemoglobins A and A2 in New World primates: comparative variation and its evolutionary implications. Hemoglobin A(2) (alpha(2)delta(2)) in New World primates represents about 1/160 to 1/16 of total hemoglobin and, by virtue of this low proportion, is presumed to be functionally unimportant. Nonetheless, A(2) exhibits genetic polymorphism by electrophoresis in three out of five genera, whereas the major component, hemoglobin A (alpha(2)beta(2)), is electrophoretically invariant. Moreover, in four genera, including man, the evolutionary accumulation of mutations has been greater in delta than in beta Such findings suggest that both polymorphism and evolutionary changes can accrue to an effectively functionless and thus selectively nearly netutral gene.


Mouse transplantable tumor induced by human spinal meningioma implant in mice inoculated with human thymus antiserum.


Limitations of he Dixon plot for ascertaining  naure of enzyme inhibition.


Isolation of all tryptic peptides from the aminoethylated beta polypeptide chain of adult hemoglobin from Japanese monkey (Macaca fuscata fuscata) and their amino acid compositions.


Isolation of all soluble tryptic peptides from the alpha polypeptide chain of adult hemoglobin from Japanese monkey (Macaca fuscata fuscata) and their amino acid compositions.


The N-terminal structure of adult hemoglobin from Japanese monkey (Macaca fuscata fuscata) and the N-terminal amino acids of all the tryptic peptides from its alpha and beta polypeptide chains.


Iron excretion in thalassemia after the administration of chelating agents.


Immunological activity of ribonucleoproteins. II. Immune diffusion studies of ribonucleoproteins extracted from guinea pig liver.


Immunological activity of ribonucleoproteins. 3. Changes in mammalian ribonucleoproteins upon the effect of whole body x-irradiation.


Transformation of phage resistance.

Transformation of phage resistance.


The structure and biosynthesis of hemoglobins A and A2 in the new world primate Ateles paniscus: a preliminary account.


Primary inoculation complex (tuberculous chancre).


Control of excitation transfer in photosynthesis. II. Magnesium ion-dependent distribution of excitation energy between two pigment systems in spinach chloroplasts.


The energy-linked nature of respiration-dependent bromothymol blue color decrease in submitochondrial particles.


Characterization of placental alkaline phosphatase from three primates: African green and rhesus monkey and baboon.


Subtyping haptoglobins with precipitating antisera. II.


Cross reactivities in lepromin.

Cross reactivities in lepromin.


Antigenicity of wax D. IV. Its relationship to other hemagglutination reactions.


Studies on subsporin. I. Isolation and characterization of subsporins A, B and C.


Studies on the nephritogenecity of hemolytic streptococcus.


Clinical management of shock.

Clinical management of shock.


Combat surgery in communication zone. I. War wound and bacteriology (preliminary report).


A rapid method of performing quantitative wound cultures.


Maxillofacial injuries sustained in the Vietnam conflict.


Psychiatric management of combat reactions with emphasis on a reaction unique to Vietnam.


Suicide attempt with Azo Gantanol resulting in methemoglobinemia.


Nephrotic syndrome and acute hepatitis in secondary syphilis.


Electrocardiographic abnormalities in acute pancreatitis: two patients studied by selective coronary arteriography.


Aeromedical evaluation--a philosophy.

Aeromedical evaluation--a philosophy.


Abnormal post-exercise electrocardiogram due to iatrogenic hyperthyroidism.


Effects of morphine and nalorphine on the phenylquinone-induced syndrome in monkeys.


Reliability of biologic autoclave sterilization indicators.


The rapid papainisation of red cells for the detection of Rh antibodies.


Subtyping of human haptoglobins with precipitating antisera I.


Identification of an asaccharolytic Neisseria strain causing meningitis.


Treatment of acute renal failure with intravenous essential L-amino acids.


High caloric glucose-nitrogen infusions. Postoperative management of neonatal infants.


Drug induced changes of abnormal movements in monkeys with central nervous system lesions.


Enzymatic hydrolysis of N-substituted aminoacyl transfer ribonucleic acid in yeast.


Endonuclease II of Escherichia coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid.


Two species of Bacillus subtilis tyrosine transfer ribonucleic acid. Biological properties and alteration in their relative amounts during growth.


Pleiotrophy in a cysteine-requiring mutant of Samonella typhimurium resulting from altered protein-protein interaction.


The utility of superoxide dismutase in studying free radical reactions. I. Radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen.


Hemoglobin Richmond, a human hemoglobin which forms asymmetric hybrids with other hemoglobins.


Properties of purine nucleoside phosphorylases from spores and vegetative cells of Bacillus cereus and their modification by orthophosphate.


Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver.


Comparison of the effects of divalent ion chelating agents on complement-mediated hemolysis in rabbit and human serum.


Serologic classification of chimpanzee adenoviruses by hemagglutination and hemagglutination inhibition.


Structural localization of isotypic markers on mouse myeloma gamma G globulins.


Two anticomplementary factors in cobra venom: hemolysis of guinea pig erythrocytes by one of them.


Immunochemical studies on the poly-gamma-D-glutamyl capsule of Bacillus anthracis. VI. The in vivo fate and distribution to immunized rabbits of the polypeptide in immunogenic and nonimmunogenic forms.


Evoked aggressive behavior in Cebus apella: a new world primate.


Impairment of delayed matching in monkeys by chlorpromazine and pentobarbital.


Radiotherapy in cancer of the breast.

Radiotherapy in cancer of the breast.


Extrinsic adrenergic innervation of the extrahepatic biliary duct system in guinea-pigs, cats and rhesus monkeys.


Investigations on iodine metabolism of normal and goitrous dogs.


Micromorpholigical studies on the coronary vessels of the buffalo (Bos-Bubalus-bubalis L.). I. Micromorphology of the coronary arteries in buffalo-fetuses.


Prenatal growth of some organs in the Egyptian water buffalo (Bos-Bubalus-bubalis-L.). Relation between body weight and brain, thymus, stomach and oesophagus weights.


Prenatal growth of some organs in the camel (Camelus dromedarius). Relation between body weight and brain, thymus, stomach and oesophagus weights.


The pathology of strychnine hydrochloride poisoning in dogs.


Dose rates and field homogeneity of Siemens 42 MeV betatron.


The place of prophylactic antibiotic in peritoneal dialysis.


Lysis inhibition of phi-X174-, M12-, and Q-beta-infected Escherichia coli bacteria by magnesium ions.


Myogenic tone in isolated perfused vessels. Occurrence among vascular beds and along vascular trees.


A permanent change in brain function resulting from daily electrical stimulation.


Effects of high hydrostatic pressures on the activity and behaviour of the ciliate Spirostomum.


The nigrostriatal pathway: a correlative study based on neuroanatomical and neurochemical criteria in the cat and the monkey.


Immunoglobulin determinations for the detection of perinatal infections.


Serum gamma-M globulin responses in acute neonatal infections and their diagnostic significance.


Immunoglobulin M determinations in neonates and infants as an adjunct to the diagnosis of infection.


Erythropoietin release from baboon renal allografts treated with subcellular kidney cell fractions.


Motion picture: simple operation for cure of diverticula of female urethra.


Lactose-chloride ratio of different milks.


Comparative studies on the prenatal growth of the brain, thymus, stomach and oesophagus in the camel (Camelus dromedarius) and Egyptian water buffalo (Bos-Bubalus-bubalis L.).


The trend of infection with drug-resistant strains of Mycobacterium tuberculosis among untreated patients. I. Isoniazid.


Analyzing the roles of the partners in a behavioral interaction--mother-infant relations in rhesus macaques.


Sewage sludge conditioning and disinfection by gamma irradiation.


Effects of separation from mother on the emotional behavior of infant monkeys.


Fragmental organization of emotional behavior in the monkey brain.


The open field: some comparative data.

The open field: some comparative data.


Hyperactive states related to the metabolism of norepinephrine and similar biochemicals.


Autonomic and behavioral responses of the rhesus monkey to emotional conditioning.


Fever therapy technique in syphilis and gonococcic infections.


Perinal mortality associated with mode of induction of labour in R-immunized patients.


Recent studies on acquired immunity in tuberculosis.


Lack of specificity of some commercial antiglobulin conjugates in indirect immunofluorescence tests.


The pathology of an erosive stomatitis and enteritis in West-African dwarf goats.


The metabolic significance of exchangeable cellular thyroxine.


Psychopharmacological activity of the active constituents of hashish and some related cannabinoids.


Clinical evaluation of carbenicillin in pseudomonas infections of the urinary tract.


Malignant pheochromocytoma.

Malignant pheochromocytoma.


Immunological paradoxes: theoretical considerations in the rejection or retention of grafts, tumors, and normal tissue.


Proline transport by Pseudomonas aeruginosa.


Immunological methods in brucellosis research. I. In vitro procedures.


Steroid metabolism in vitro by the adrenal cortex from male and female monkeys, Macca mulatta.


Plasma diamine oxidase activity after single or chronic administrations of histamine.


An immunologic study of the relationships of non-human primates to man.


Fluorescence of dermostatin.

Fluorescence of dermostatin.


Iso-antigens of serum proteins of the chicken.


A specific antiserum to lysosomal cathepsin D.


Metabolism of macromolecules in bacteria treated with virginiamycin.


The action of virginiamycin on nucleic acid and protein synthesis in Bacillus subtilis infected with bacteriophage 2C.


The role of amine buffers in EDTA toxicity and their effect on osmotic shock.


Characteristics of two lysine-independent strains of Streptococcus faecalis.


Butyramide-utilizing mutants of Pseudomonas aeruginosa 8602 which produce an amidase with altered substrate specificity.


Opposite effect of illumination and d-amphetamine upon activity in the squirrel monkey (Saimiri) and owl monkey (Aotes).


Further observations on human anti-LDL antibodies: serological behaviour, frequency and mode of formation.


The protein moiety of the endotoxin of Pseudomonas aeruginosa.


The application of autoradiography to the study of soluble compounds.


Basic nuclear aspects of autohistoradiography (with suggestions concerning color autoradiography).


A simple method for determination of absolute "specific acitivity" in individual cells.


Biological implications of DNA-turnover in higher organisms.


Contribution of histoautoradiography to the study of nucleic acids and proteins in cells.


Effects of a passive administration of humoral antibodies, sensitized polymorpholeukocytes and immunologically competent lymphocytes in rabbits supporting transparent inter-lamellar chicken corneal grafts.


Bone dysplasias, including Morquio's syndrome, studied in skin fibroblast cultures.


Persistent atrial standstill in a family with myocardial dease.


Serum thyroxine specific activity (T4SA) in the diagnosis of thyroid dysfunction.


Experimental production of pigmented villonodular synovitis in the knee and ankle joints of rhesus monkeys.


Timely topics in microbiology: Mycobacteria 1967-1968.


Cutaneous diphtheria: a laboratory note.


Rare primary orbital sarcomas.

Rare primary orbital sarcomas.


Glucose intolerance in monkeys following head injury.


Recell iso-antigens of Rhesus monkeys.

Recell iso-antigens of Rhesus monkeys.


Ultracentrifugal characterization of a lipoprotein occurring in obstructive jaundice.


The use of quantitative immunoelectrophoresis to investigate thyroxine-binding human serum proteins.


Review article. Tuberculosis in childhood.


Eosinophil granule lysis in vitro induced by soluble antigen-antibody complexes.


Bacterical activity of rabbit serum containing immnoconglutinin.


Species distribution of ribonucleoprotein-derived brain antigens.


Anti-inflammatory activity of Semecarpus anacardium Linn. A preliminary study.


Immunoreactive basement membrane antigens in normal human urine and serum. Using a sheep antiserum to human glomerular basement membrane (GBM), studies of urine from healthy adults showed the presence of two cross-reactive antigens. These antigens were purified partially by preparative electrophoresis and electrofocusing, and separated on G-200; both appeared to be acidic, of high molecular weight, and carbohydrate rich. Their immunologic relationship to human GBM solubilized by several techniques was deduced from lines of identity with the native GBM digests in double diffusion analyses. These antigens will combine with homologous anti-GBM antibodies and block their fixation to human kidney sections, and will evoke heterologous anti-GBM antibody production in the rabbit. Fractionation studies of normal human serum indicated the presence of trace amounts of basement membrane antigens in the circulation. Although the serum antigens appear immunologically identical to the urinary antigens, the precise anatomic structures from which both are derived is not certain. Demonstration of immunoreactive basement membrane antigens in the circulation provides a plausible source of immunogen for the potential development of anti-GBM antibody-mediated glomerulonephritis as well as a clue to a mode for reestablishment of tolerance in such an autoimmune disorder.


Immunological effects of thermal injury. I. Inhibition of spermatogenesis in guinea pigs. In the present study, controlled burns of 1 testis have induced the formation of testis-specific antibodies in Hartley guinea pigs.  The antibodies reacted with autologous as well as homologous testicular extracts.  In addition, pathological changes have been noted in the germinal components of the contralateral testis, which were similar to those observed after the induction of experimental allergic orchitis by active immunization with testicular  tissue.  Results of the study indicate that thermal injury to guinea pig testes can induce an autoimmune response similar to that observed after immunization with autologous or homologous testicular tissue.  The antibodies formed were organ-and species-specific against a testicular antigen.  Thermal injury may be associated with autoimmunization of the host by the injured organ.


Calcium disodium edetate nephrosis in female rats of varying ages.


Hydroxyanisole depigmentation: in-vitro studies.


Renal artery rupture in a pregnant woman with neurofibromatosis.


Histological changes evoked in mice by Freund's complete adjuvant.


Characterisation of antisera to a growth-hormone-like placetal antigen (human placental lactogen): immunofluorescence studies with these sera on normal nd pathological syncytiotrophoblast.


Inhibition of S-91 mouse melanoma metastases and growth by D-penicillamine.


Current therapy for carcinoma of the bladder.


The development of the baboon (Papio sp.) placenta during the fetal period of gestation.


The villous period of placentogenesis in the baboon (Papio sp.).


Two classes of spermatogonial stem cells in the monkey (Cercopithecus aethiops).


Cyclic changes in ovarian morphology during the menstrual cycle in Macaca mulatta.


Approach to fetal research--present and future.


Species specificity of ribosomal proteins in eucaryotic and procaryotic organisms.


Effect of calcium ion on S-100, a protein of the nervous system.


Molecular and catalytic properties of aldolase C.


Allotypes and isozymes of rabbit alpha-1-aryl esterase. Allelic products with different enzymatic acitivities for the same substrates.


Specificity in self-assembly of bacteriophages Q beta and MS2.


Studies on the chemical modification of staphylococcal enterotoxin B. I. Alkylation and oxidation of methionine residues.


Studies on the chemical modification of staphylococcal enterotoxin B. II. Carboxyl residues.


Phosphoproteins from calf-thymus nuclei: studies on the method of isolation.


Metabolic and molecular heterogeneity of marrow ferritin.


The association of hyaluronic acid with protein in human synovial fluid.


Tyrosyl residues and immunochemical properties of glycoproteins.


A milk clotting assay for E.D.T.A. bromelin.


The alkaline denaturation of DNA.

The alkaline denaturation of DNA. A kinetic study of the alkaline transition of DNA, in clearly defined physico-chemical conditions, is presented, which allows us to identify, within the alkaline transition region, different pH ranges, corresponding to different ratelimiting factors. This analysis brings into consideration three distinct intervals of time which characterize the whole process, namely the time necessary for full hyperchromicity to be reached, the time required for strand separation in the case of a single DNA molecule, and the time for complete denaturation to be reached in the case of a DNA solution.THE RESULTS OBTAINED FROM ULTRACENTRIFUGAL, AND SPECTROPHOTOMETRIC MEASUREMENTS, INVOLVING RAPID MIXING EXPERIMENTS, SEEM TO INDICATE THE FOLLOWING CONCLUSIONS: whereas, in the lower pH ranges considered within the transition region, the denaturation process is limited by the first time constant, this same constant becomes extremely short at higher pH. On the other hand the fact that, in the higher pH range, the second and third time constants do not coincide (the time to unwind a single T2 DNA molecule being at least one order of magnitude shorter than the time required for bulk denaturation to be reached) suggests that in this pH range the overall denaturation rate is limited by a statistical process governing the initiation of unwinding.These observations are discussed in terms of a model in which the unwinding energy is given by the electrostatic repulsions which originate in the deprotonated DNA molecule. The model itself suggests some experiment which seem to confirm it.


Electron microscopic observations on a "C"-type virus in cell cultures derived from a tumor-bearing viper.


Lack of carcinogenic activity of 3-methyl-cholanthrene in the squirrel monkey.


Histochemical detection of L-gulonolactone: phenazine methosulfate oxidoreductase activity in several mammals with special reference to synthesis of vimin C in primates.


Current trends in the prevention of bacterial endocarditis in susceptible patients receiving dental care.


Synovial chondromatosis of temporomandibular joint. Report of a case.


The effect of restricted intake of a barley diet on rumen fermentation in cattle.


The incorporation of intravenously injected 14C-labelled glucose and fructose into the serum glycerides of male and female baboons.


Operant conditioning of increases in blood pressure.


Denver's neighborhood health program.

Denver's neighborhood health program.


Use of the survey technique to achieve a highly immunized preschool population.


Trends in hospital use.

Trends in hospital use.


Alcohol level and home accidents.

Alcohol level and home accidents.


Occurrence of leprosy in U.S. veterans after service in endemic areas abroad.


Predictors of innovative behavior among local health officers.


Parenteral medroxyprogesterone as a contraceptive agent.


Epidemiology of rabies vaccinations of persons in Illinois, 1967-68.


The relevance of Yoruba medicine men in public health practice in Nigeria.


Epidemiology of human exposure to rabid animals in Illinois.


Operative needle cholangiography.

Operative needle cholangiography.


Effect of improved sanitary facilities on infant diarrhea in a Hopi village.


Urban health crisis: management of the public's health investment.


Pharmacological studies on flurazepam hydrochloride (RO 5-6901), a new psychotropic agent of the benzodiazepine class.


Anacidotic hyperglycemia and focal seizures.


A new approach to the analysis of hybridization of bacterial nucleic acids. Analysis of the ribosomal ribonucleic acids of Bacillus subtilis. A new graphical analytical technique is described for the hybridization of bacterial RNA with denatured homologous DNA immobilized on cellulose nitrate membrane filters. To a constant amount of DNA, various amounts of bacterial RNA were added and the percentage of input RNA bound was plotted against the DNA/RNA weight ratio in a given experiment. When RNA samples were used that hybridize to denatured DNA as a single species, the resulting curves (RNA-hybridization-efficiency curves) could be analysed to show the percentage of the DNA capable of specifically binding the RNA and could also be used to detect the presence of minor RNA contaminants in a purified specimen. The method could also estimate the relative amounts of two species of RNA in a mixture when these were hybridized independently to different DNA cistrons or cistron groups. As an example of RNA that can be studied in this way, the 16s and 23s ribosomal RNA species of Bacillus subtilis were chosen. These each behave in DNA-RNA hybridization as a single species and bind independently to different groups of DNA cistrons. The results obtained from hybridization-efficiency curves were compared with those obtained by the more usual method of saturating the specific DNA regions with excess of ribosomal RNA (hybridization-saturation curves). It was confirmed by both approaches that 0.15 (+/-0.02)% of B. subtilis DNA would hybridize with 16s ribosomal RNA, 0.30 (+/-0.02)% would hybridize with 23s ribosomal RNA, and 0.46 (+/-0.02)% would hybridize with (16s+23s) ribosomal RNA. This agreement suggested that mass-action equilibria between hybridized and free RNA had a negligible effect on the hybridization curves over the range of DNA and RNA concentrations employed.


The effect of magnesium ion deprivation on the synthesis of mucopeptide and its precursors in Bacillus subtilis. 1. Mg(2+) or Mn(2+) starvation causes suspensions of Bacillus subtilis strain W 23 to accumulate bound amino sugars that are soluble in trichloroacetic acid. 2. The presence of chloramphenicol or puromycin produces higher intracellular concentrations of amino sugars during Mg(2+) starvation, but neither compound can stimulate the accumulation when Mg(2+) is present. 3. The major component of the amino sugar fraction extracted from cells deprived of Mg(2+) is a nucleotide containing uridine, phosphorus, N-acetylmuramic acid, alanine, glutamic acid and alphain-diaminopimelic acid in the molar proportions of 1:2:1:3:1:1. This compound represents at least 80% of the bound N-acetylhexosamine extracted by trichloroacetic acid. 4. Studies of the binding of this nucleotide with vancomycin support the proposal that it is the mucopeptide precursor UDP-N-acetylmuramyl-l-alanyl-d-glutaminyl- alphain-diaminopimelyl-d-alanyl-d-alanine. 5. A method is described for the isolation of this material labelled with [(3)H]alphain-diaminopimelic acid. 6. When Mg(2+) is supplied to cells previously starved of Mg(2+), the accumulated pool of amino sugars rapidly decreases. 7. The biosynthesis of mucopeptide is inhibited by 35-50% under conditions of Mg(2+) starvation. The presence of EDTA increases this inhibition to 70%. The amount of N-acetylhexosamine that accumulates is balanced exactly by the associated fall in mucopeptide synthesis. 8. ;Chase' experiments show that the accumulated N-acetylhexosamine compound is utilized in mucopeptide synthesis.


Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. 1. The methods for the assay of choline acetyltransferase were based on the reaction between labelled acetyl-CoA and unlabelled choline to give labelled acetylcholine. 2. Both synthetic acetyl-CoA and acetyl-CoA formed from sodium [1-(14)C]acetate or sodium [(3)H]acetate by incubation with CoA, ATP, Mg(2+) and extract from acetone-dried pigeon liver were used. 3. [1-(14)C]Acetylcholine was isolated by extraction with ketonic sodium tetraphenylboron. 4. [(3)H]Acetylcholine was precipitated with sodium tetraphenylboron to remove a ketone-soluble contaminant in sodium [(3)H]acetate and then extracted with ketonic sodium tetraphenylboron. 5. The values of choline acetyltransferase activity obtained in the presence of sodium cyanide or EDTA and synthetic acetyl-CoA were similar to those obtained with acetyl-CoA synthesized in situ. 6. The assay of acetylcholinesterase was based on the formation of labelled acetate from labelled acetylcholine. The labelled acetylcholine could be quantitatively removed from the acetate by extraction with ketonic sodium tetraphenylboron. 7. The methods were tested with samples from central and peripheral nervous tissues and purified enzymes. 8. The blank values for choline acetyltransferase and acetylcholinesterase corresponded to the activities in 20ng. and 5ng. of brain tissue respectively.


Immunoglobulin synthesis in neonatal nurse sharks (Ginglymostoma cirratum).


Evidence for two molecular forms of streptococcal erythrogenic toxin. Conversion to a single form by 2-mercaptoethanol.


The induction of yolk protein synthesis in the fat body of an insect, Leucophaea maderae, by an analog of the juvenile hormone.


Review article. Experimental studies of ageing in rotifers.


Effect of photooxidation on hum caeruloplasmin.


Incidence of malformations in dead poultry embryos.


The effect of ethylenediaminetetra-acetate washing on the structure of spinach thylakoids.


Immunological studies on leukemia with special reference to the circulating antibodies against the human leukemic antigens in human sera.


Cyclical transmission of Chesson vivax malaria in subhuman primates.


The cost of disease.

The cost of disease.


Evaluation of a silicone lubricant injected spinally.


Ethylene glycol toxicity in the monkey.

Ethylene glycol toxicity in the monkey.


The toxicologic and pharmacologic properties of amantadine hydrochloride.


Stability of blood in commonly used anticoagulants. Use of refrigerated blood for quality control of the Coulter Counter Model S.


A soluble antigen fluorescent antibody test for the serodiagnosis of Mycobacterium tuberculosis infection.


Pharmacology of SR 720-22.

Pharmacology of SR 720-22.


The effect of rifampin on the production of beta22 phage by Bacillus subtilis.


Action of some antibiotics on the extra-hepatic biliary tract. V. Aminosidin.


The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide.


Studies on acid deoxyribonuclease from brain.


Squamous cell carcinoma arising in a pharyngoesophageal diverticulum.


Generalized melanosis secondary to malignant melanoma. Report of a case with serum and tissue tyrosinase studies.


Therapeutic implications from a mathematical model characterizing the course of breast cancer.


Studies of patients in a laminar air flow unit.


Prospects for the control of metastases.


Systemic chemotherapy as an adjuvant to surgery in the treatment of breast cancer.


Cancer of the breast. Statistical and epidemiological data.


Formate: cytochrome oxidoreductase of Desulfovibrio vulgaris.


Studies on the purine-sensitive mutants of Bacillus subtilis. I. Properties of an adenosine-sensitive mutant.


Comparative studies on muscle aldolases purified from rat, rabbit, human, pigeon, and hen.


Atrophic cortical sclerosis associated with status marmoratus in a perinatally damaged monkey.


Histochemical studies on the morphology of the Golgi apparatus and on the relationship between the Golgi apparatus and lysosomes in the cellular elements of the rabbit area postrema with the thiamine pyrophosphatase and acid phosphatase methods.


Non-specific esterases and cholinesterases in the human dental pulp.


An integrating apparatus for microinterferometry.


Changes in the histochemical behaviour of cultured cells due to differences in the serum component of the medium.


Histochemical researches on the hepatocyte in experimental re-feeding conditions following starvation. On the activity of some oxido-reducing enzymes.


Histochemical studies on ribonuclease activity in the adipose tissue of rat.


The oxidative enzymes in the wall of the small and large intestine of young rats during postnatal development.


Changes in the distribution of neutral lipid in liver of tadpoles at various stages of development of larval life.


Purification and properties of lactase from monkey kidney.


Purification and properties of rat liver AMP deaminase.


Beta-radioactivity of herbs from the region of Balkans Central Sredna Gora.


Temporary disability to work caused by diseases of the upper respiratory tract in the tobacco industry of Plovdiv.


Professor Svetlana Bojkikeva. (Biographical sketch).


Syndrome of Paget-Schröetter (thrombosis) of v. subclavia.


The isolation of IgG from mammalian sera with the aid of caprylic acid.


Substrate-like inhibitors of diamine oxidase: some relations between the structure of aliphatic aminoketones and their inhibitory effect.


Rhesus sensitization and abortion.

Rhesus sensitization and abortion.


Central sympathetic discharge and mean arterial pressure during halothane anaesthesia.


Avian-Battey mycobacteria infection.

Avian-Battey mycobacteria infection.


Enzymatic inactivation of parathyroid hormone by rat kidney homogenate.


Immunological adjuvants. 3. A preliminary report about the mode of action of mycobacterial adjuvants and further confirmation of adjuvant activity of acetylated wax D.


Effects of autonomic blocking agents on growth hormone, insulin, free fatty acids and glucose in baboons.


Arthritogenicity of unaltered and acetylated cell walls of mycobacteria.


Relationship between the latent form and the active form of the autolytic enzyme of Streptococcus faecalis. A 10-hr starvation of Streptococcus faecalis ATCC 9790 for the amino acids methionine and threonine results in cells which are resistant to autolysis and which contain greatly reduced quantities of both active and latent (proteinase activable) forms of the autolytic enzyme (an N-acetyl-muramide glycanhydrolase). Cell walls were isolated from cells harvested at various times during the recovery from such starvation and were assayed for active and latent forms of the autolysin. Within 10 min of recovery the latent enzyme began to increase. Only after 30 to 60 min did the active enzyme begin to increase; after a similar lag, the cells' proneness to lysis markedly increased. The intracellular localization of both forms of the autolysin was examined, using as an experimental tool the ability of added cell wall to bind autolysin. (14)C-lysine-labeled, inactivated cell walls were added to exponential-phase cells, which were then disrupted, and the mixed wall population was isolated. Measurement of the (14)C release during wall autolysis indicated that the active enzyme in the cells was not available for binding to the added (14)C-labeled walls and was therefore wall-bound in vivo. In contrast, up to 85% of latent autolysin activity was found to have been efficiently bound to the added (14)C walls. The results obtained suggest (i) cellular autolysis is a reflection of the level of active enzyme and not of latent enzyme, and (ii) autolysin is synthesized and mainly located in the cytoplasm as an inactive latent precursor (proenzyme) which is transported to sites on the cell wall associated with wall biosynthesis, where it becomes activated.


Identification of Bacillus subtilis NRRL B-3275 as a strain of Bacillus pumilus. The physiological and biochemical properties of a species of Bacillus previously identified as B. subtilis NRRL B-3275 (B-3275) were compared with those of seven strains of B. pumilus and five strains of B. subtilis. The biotin requirement of B-3275, its inability to hydrolyze starch, and its failure to reduce nitrate indicate that the organism is more closely related to the B. pumilus strains than to those of B. subtilis. Hybridization of deoxyribonucleic acid (DNA) from B-3275 with that of the strains of B. pumilus showed a binding efficiency (compared with the homologous reaction) of 58 to 99%, depending on the strain. Hybridization with the DNA from any of the strains of B. subtilis did not exceed 24%. DNA from B-3275 was unable to transform two amino acid auxotrophic markers to prototrophy in a highly competent strain of B. subtilis 168. We conclude that B-3275 is a strain of B. pumilus which we designate as B. pumilus NRRL B-3275.


Raffel S, Ferraresi RW: Delayed hypersensitivity in relation to suppression of growth of Listeria monocytogenes by guinea pig macrophages. Prototypes of delayed hypersensitivity (tuberculin allergy, graft rejection immunity, and contact dermatitis) were established in guinea pigs. The macrophages from peritoneal exudates of such animals were examined for their capacities to suppress the growth of Listeria monocytogenes in vitro. Only the macrophages from animals sensitized to BCG clearly exhibited this property.


Specific loss of newly replicated deoxyribonucleic acid in nalidixic acid-treated Bacillus subtilis 168. Bacillus subtilis 168 thyA, thyB cells degrade and lose from 20 to 30% of their deoxyribonucleic acid (DNA) in 3.5 hr of exposure to 20 mug of nalidixic acid per ml. Degradation appears to be initiated at the replication point and to proceed sequentially along the chromosome from the most recently synthesized DNA to "older" DNA. Both DNA strands appear to be degraded equally, and essentially all of the products of degradation are soluble in cold acid.


Effect of inhibitors on phenoloxidase of Mycobacterium leprae. Previous results had shown that the human leprosy bacilli possess a phenoloxidase, which, when compared with the enzyme from mammalian and plant sources, seemed unique in the range of substrates utilized and in the nature of the products formed. The effect of several inhibitors on the enzyme in Mycobacterium leprae was tested. Compounds which bind copper were found to be more effective than substrate analogues. Diethyldithiocarbamate penetrated the bacillus and completely suppressed its phenolase activity. Diasone (a derivative of diaminodiphenylsulfone used in the treatment of leprosy) proved to be a potent inhibitor of phenoloxidase of mammalian and plant origin. However, it was less efficient in the case of M. leprae. A biochemical peculiarity of M. leprae was observed in its ability to metabolize mimosine and penicillamine. These compounds produced total inhibition of tyrosinase in melanoma extract and of mushroom tyrosinase. Nontoxic inhibitors of phenoloxidase in the leprosy bacilli may be of value in developing a rational approach to chemotherapy of the disease.


Cholera toxins: immunogenicity of the rabbit ileal loop toxin and related antigens. A method of assay of immunogenic potency of the cholera gut toxin is described; it is based on the relation of dose of antigen to neutralizing antibody titer produced in the rabbit under defined conditions and allows quantification of immunogenicity as immunogenic units per milligram of protein. Evidence, based on immunogenicity and rabbit ileal loop toxicity, is presented which indicates that the positively charged fraction of liquid-culture supernatant fluid eluted in deionized water from diethylaminoethyl Sephadex, or in electrolyte from carboxymethyl Sephadex, is a complex made up of a nonantigenic toxic moiety, a nontoxic protein component which elicits the formation of toxin-neutralizing antibody, and an inactive fraction. The complex may also be dissociated in high-salt concentrations with apparent recombination of the toxic moiety with a nondialyzable constituent of peptone to give a negatively charged complex. The immunogenic component is found in nontoxic supernatant fluids of cultures grown at pH 6.5 or in media deficient in peptone. It is also present in the nontoxic fraction eluted from diethylaminoethyl Sephadex in electrolyte or in deionized water from carboxymethyl Sephadex. When separated from the positively charged toxic moiety, the net charge of the antigen is reduced as shown by immunoelectrophoresis. On primary fractionation, the antigen may be associated with a minor antigenic component of the negatively charged complex containing a major antigen eliciting vibriocidal antibody formation, but antisera to the toxin antigen preparations, either in this form or freed of antigenic contamination by recycling, do not contain vibriocidal antibody. It is suggested that this antigen be designated the T (toxin) antigen, and the antigen producing vibriocidal antibody the V antigen. These two antigens would appear to represent the major antigenic specificities associated with the antitoxic and antibacterial elements of the immune response to infection.


Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine trihosphate.


Effects of bilirubin on mitochondrial reactions.


Formation of enzyme-substrate complexes with protocollagen proline hydroxylase and large polypeptide substrates.


Streptococcal related glomerulonephritis.


An electron microscopic characterization of classes of synaptic vesicles by means of controlled aldehyde fixation. Examination of variables of aldehyde fixation that may affect the shape of agranular synaptic vesicles has revealed that even brief storage of aldehyde-perfused nervous tissue pieces in cacodylate buffer, prior to hardening in osmium tetroxide, has an unusually severe flattening effect on agranular vesicles of a particular type. These are the vesicles of peripheral cholinergic axon endings, and of certain central synaptic bulbs. Types of synaptic bulbs can now be further defined on the basis of shape of agranular synaptic vesicles under controlled conditions of aldehyde fixation. Previously described "S" bulbs in the spinal cord contain uniformly spheroid vesicles, which are wholly resistant to flattening. Previously described "F" bulbs contain somewhat smaller agranular vesicles that are flattened after aldehyde fixation, even when this is followed by prompt hardening in osmium tetroxide solution. A third type, previously characterized as having irregularly round agranular vesicles after the above treatment, contains only severely flattened vesicles when the osmium tetroxide hardening is preceded by even a brief wash with sodium cacodylate buffer containing sucrose. Moreover, the "third" type is characteristic of all cholinergic peripheral axon endings examined, as well as the large axosomatic ("L") synaptic bulbs of the spinal cord.


Isoenzyme characterization of animal cell cultures.


Correlation between immunoreactive growth hormone and prolactin activity in human and simian pituitary cell cultures.


Antimicrobial activity of catalase at acid pH.


Biological characteristics and viral susceptibility of an African green monkey kidney cell line (Vero).


Chimpanzees: self-recognition.

Chimpanzees: self-recognition. After prolonged exposure to their reflected images in mirrors, chimpanzees marked with red dye showed evidence of being able to recognize their own reflections. Monkeys did not appear to have this capacity.


Statistics of health services and of their activities. Thirteenth report of the WHO Expert Committee on Health Statistics.


Triiodothyronine binding affinity for thyroxine-binding globulin in serum from normal subjects and from hyperthyroid, hypothyroid and pregnant patients.


Ocular myopathy with pre-pubertal functional castration syndrome.


Tests on ticks from wild birds collected in the eastern United States for rickettsiae and viruses.


Distribution of mature trophozoites and schizonts of Plasmodium falciparum in the organs of Aotus trivirgatus, the night monkey.


Isolation of Trypanosoma cruzi from blood of acutely and chronically infected mice in tissue culture.


Effects of an anion exchange resin (cholestyramine) on atherogenesis in rhesus monkeys.


Ultrastructure of human and monkey lamina cribrosa and optic nerve head.


Slow viruses and inborn metabolic errors. Summary of a workshop sponsored by the National Institutes of Health.


Collagen implants in the vitreous.

Collagen implants in the vitreous.


Thyroid and steroid hormones and metabolic parameters in myocardial infarction.


Some observations on hepatic ossification in a goose.


Morphological and pharmacohistochemical characteristics of adrenergic retinal neurons of some mammals.


Unusual laboratory findings in a case of haemolytic disease of the newborn.


Inheritance of human alpha-1-acid glycoprotein (orosomucoid) variants. Although variants of sialic acid-free alpha(1)-acid glycoprotein have been described in human beings, the mode of inheritance of these types has not been reported previously. With the use of a new technique of immunofixation after agarose gel electrophoresis of neuraminidase-treated whole serum, the present study demonstrates that the types of alpha(1)-acid glycoprotein variants in family members are consistent with inheritance as autosomal traits with codominant expression. Gene frequencies have been determined for several ethnic groups. Of a total of 11 maternal-cord serum pairs, seven were discordant types, indicating that the fetus synthesizes alpha(1)-acid glycoprotein and confirming a previous report that there is no significant transplacental passage of this protein.


A mucoid strain of Pseudomonas aeruginosa.


Immunochemical studies in four cases of alpha chain disease. Studies of a number of properties of the pathological gammaA-proteins in the first four cases of the recently recognized alpha-chain disease demonstrate that, as in gamma-heavy-chain disease, the abnormal protein is devoid of light chains and represents a portion of the alpha-heavy chain related to the Fc-fragment. In two patients, serum electrophoresis showed a broad abnormal band, whereas in the two others the pathological protein was not noticeable on the electrophoretic pattern. The diagnosis of alpha-chain disease can be established without purification of the protein by immuno-electrophoresis and gel diffusion experiments using selected antisera to gammaA and a reference alpha-chain disease protein. All four proteins belonged to the alpha1-subclass, displayed electrophoretic heterogeneity, and showed a strong tendency to polymerize. The polymers occurred in vivo and were held together both by disulfide bonds and by strong noncovalent forces. Two of the three purified proteins had a very high carbohydrate content. The abnormal protein was always found in concentrated urines in variable but generally low amounts. It was not detected in parotid saliva but was present in significant amounts in jejunal fluid of all four patients. The alpha-chain disease protein was shown to be associated with the secretory piece in external secretions of two patients. The clinicopathological features were strikingly similar in the four patients. All patients were affected with a neoplastic and mostly plasmacytic proliferation involving primarily the whole length of the small intestine and the mesenteric nodes and all exhibited a severe malabsorption syndrome. While Israeli authors have emphasized the frequency of this type of abdominal lymphoma in young Arabs and non-Ashkenazi Jews, two of our patients were Kabyles, one a Syrian Arab, and one an Eurasian. Cellular studies showed that the pathological protein was synthesized by the proliferating cells in the lymphoid tissue of the digestive tract and in the mesenteric nodes, and that there was no detectable light-chain synthesis at the intracellular level.


Mycobacterium tuberculosis strain H37Rv.


Uptake of DNA by competent bacteria--a possible mechanism.


"Abacterial" and bacterial pyelonephritis. Immunofluorescent localization of bacterial antigen.


Influence of enzyme activators and inhibitors, present in an enzyme preparation, on the relations between reaction rate and enzyme concentration.


Absorption and distribution of ethylenediaminetetraacetic acid (EDTA) ingested by the chick.


Effects of phytic acid and ethylenediaminetetraacetic acid (EDTA) on the chick's requirements for magnesium.


Gastrointestinal transit-times in normal and bluecomb diseased turkeys.


A molecular time scale for human evolution. We discuss published molecular evidence concerning the relationship of man to African apes and Old World monkeys. Quantitative comparisons of their serum albumins, transferrins, hemoglobins, and DNA show that man is genetically much more similar to the African apes than to the Old World monkeys. The amino acid sequences of hemoglobins from humans, chimpanzees, gorillas, and rhesus monkeys are consistent with the hypothesis that the probability of an amino acid substitution occurring in a given interval of time is the same for every hemoglobin lineage. This allows the use of these data as a hemoglobin evolutionary clock, just as we have previously done with the albumins. It is shown that concordance exists between the hemoglobin and albumin results and that both support the suggestion that the human lineage diverged from that leading to the African apes far more recently than is generally supposed. Considering both the albumin and hemoglobin data, we would set the most probable date at 4 to 5 million years.


The effects of centrally acting drugs on tremor in monkeys with mesencephalic lesions. The effects of centrally acting drugs on tremor were investigated in monkeys with ventromedial tegmental lesions exhibiting hypokinesia or hypokinesia and tremor. In monkeys with resting tremor, the administration of DL-5-HTP (5-hydroxytryptophan) or of DL-DOPA (3,4-dihydroxyphenylalanine) relieves the tremor, but the simultaneous administration of DL-5-HTP or DL-DOPA and atropine results in a much more pronounced relief. These results point to an imbalance between the cholinergic and adrenergic-serotonergic systems in parkinsonism. In monkeys exhibiting hypokinesia, the administration of harmaline evokes a marked resting tremor of the extremities contralateral to the tegmental lesion. The production of tremor by harmaline is not abolished by lowering the striatal amine levels with specific inhibitors of amine synthesis. Administration of DL-5-HTP protects monkeys from tremors induced by harmaline, which might affect the functions of the central nervous system by interaction with receptors for serotonin. The present results further demonstrate the apparent role of biogenic amines in the extrapyramidal dysfunctions.


On the proportions between some areas of the first cervical segment of the spinal cord of primates. It has been generally supposed that the dorsal funiculi occupy a relatively larger part of the highest segments of the spinal cord in man than in any other primate. We have taken planimetric measurements of the total area of the cord, dorsal funiculi, and total gray in the uppermost segments of the spinal cord of a wide variety of primates. Our results indicate that the largest values for the proportions dorsal funiculi/total white matter and dorsal funiculi/ventrolateral funiculi are found in gorilla, chimpanzee, and orang, rather than in man. Moreover, man has, on the average, smaller dorsal funiculi in relation to either the total white or ventrolateral funiculi than any of the three great apes.


The control of schistosomiasis in Patillas, Puerto Rico.


The participation of optometrists in New York City's Medicaid program.


Relating health and social contacts to the morale of elderly persons.


A study of the application of laminar flow ventilation to operating rooms.


A proposal for revision of curriculums of schools of public health.


Low birth weight and perinatal mortality.


Awareness of sickle cell anemia among negroes of Richmond, Va.


Visual acuity and field of vision of urban and rural Egyptians.


Tribal community health representatives of the Indian Health Service.


Malformations recorded on birth certificates following A2 influenza epidemics.


Comparative study of two therapies for gonorrhea.


Preliminary report of a recall program for persons with inactive tuberculosis.


Social status and subjective perceptions of 250 men after myocardial infarction.


Role of the community health aide in public health programs.


Allergic alveolitis in maltworkers. A clinical, mycological, and immunological study.


The ultrastructure of free intestinal cells isolated with EDTA.


Studies on plasma histaminase levels in normal and allergic individuals.


Comparison of mesoridazine and chlordiazepoxide in psychoneurotic patients.


A controlled trial of a new analgesic (Z.424) in experimental and pathological pain in comparison with codeine and aminopyrine.


Hydroxyzine, amitriptyline and their combination in the treatment of psychoneurotic patients.


Comparison of trifluoperazine and molindone in chronic schizophrenic patients.


The effect of calcium on behavior and drug-induced extrapyramidalism.


Plasma salicylate concentrations following chronic administration of aspirin as conventional and sustained-release tablets.


Hetacillin potassium oral solutions: absorption of pediatric formulations.


Comparison of serum and urine concentrations of doxycycline and tetracycline phosphate complex.


A comparison of irritative and allergenic properties of adhesive bandages.


Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas.


The ocular effects of repeated dermal applications of dimethyl sulfoxide to dogs and monkeys.


The effect of N-gamma-phenylpropyl-N-benzyloxy acetamide (W-1372) on experimental atherosclerosis and hypercholesteremia.


Anthranilic acid as precursor of alkaloids.


Chromosomal changes in 20-methylcholanthrene induced sarcomas in mice in relation to time of appearance of the tumours.


Delayed inhibition of epidermal DNA synthesis after injection of an aqueous skin extract (chalone).


Simultaneous respiratory and histological studies on mouse skin during carcinogenesis with DMBA.


Cell proliferation and time of appearance of sarcomas induced with 20-methylcholanthrene in mice.


Follow-up studies of Cebus apella exposed to heavy infections with Schistosoma mansoni.


Adrenergic retinal neurons of some new world monkeys.


The pancreatic islet system of the mouse (Mus musculus). Ultrastructural report of six new cell types.


Medical certification of civil pilots following head trauma.


Pathogenesis of oncogenic simian adenoviruses VI. An ultrastructural investigation of SV30 replication.


Time course of the negative feedback control of cholesterol synthesis in rats.


Mycoplasma pneumonia.

Mycoplasma pneumonia.


Complement components required for virus neutralization by early immunoglobulin antibody. Virus neutralization by early antisera usually requires or is enhanced by the presence of complement. The particular components of the complement system which are needed for neutralization of Newcastle disease virus by early IgM antibodies were studied. It was found in this system that participation of only the first four of the nine complement components (C1, C2, C3, and C4) was necessary and sufficient for neutralization to occur. It was concluded that the role of complement in neutralization was most likely that of contributing bulk in the form of large protein molecules to the virus-antibody complex.


Structure of the peptidoglycan of bacterial spores: occurrence of the lactam of muramic acid. Six major oligosaccharides were released from the peptidoglycan of spores of Bacillus subtilis by lysozyme treatment. They were isolated and characterized as a disaccharide, tetrasaccharide, and hexasaccharide composed of equal amounts of muramic acid and glucosamine and containing two, three, and four acetyl groups, respectively. Three of the compounds were substituted by a single L-alanine residue, and the other three by a single tetrapeptide substituent on the acetylmuramic acid residue at the reducing end of each compound. The other muramic acid residue in the tetrasaccharides (and two of the three in the hexasaccharides) were shown to be present as muramic lactams, a sugar not previously found in nature and, hence, a unique spore constituent. Other features of the structure of spore peptidoglycan are discussed.


Heterogeneous circular DNA elements in vegetative cultures of Bacillus megaterium. DNA preparations from two strains of Bacillus megaterium, one which produces megacin and another that is megacin sensitive, were analyzed by dye-buoyant density centrifugation, cesium chloride gradient equilibrium centrifugation in the absence of dye, zone sedimentation in sucrose, and electron microscopy. Both strains were found to contain a substantial proportion of their total DNA as circular, covalently closed, double helical molecules. These DNA elements were heterogeneous in size and appeared slightly less dense than chromosomal DNA. The physiological role and origin of these elements is unknown at present.


Ribosomal RNA genes in bacteria: evidence for the nature of the physical linkage between 16S and 23S RNA genes in Bacillus subtilis. The nature of the arrangement of 16S and 23S ribosomal RNA genes on the Bacillus subtilis chromosome was studied by means of a Cs(2)SO(4) density gradient centrifugation technique after complexing DNA-(ribosomal) RNA hybrids with mercuric ions. It was observed that the same fragments of single-stranded DNA with an average molecular weight of 1.9 x 10(6) which hybridize with 23S RNA also hybridize with 16S RNA. This indicates that genes for both these species of ribosomal RNA are physically linked on such DNA fragments. Some evidence suggests that the two types of genes are interspersed with each other, perhaps in sets, each of which contains a 16S and a 23S ribosomal RNA gene.


The nerve growth factor: purification as a 30,000-molecular-weight protein. The nerve growth factor protein was purified over 100-fold from adult mouse salivary glands. The first step was a gel filtration on Sephadex G-100 at pH 7.5 of the aqueous gland extract. After gel filtration, most of the NGF activity was eluted in the 80,000-90,000-molecular-weight region (G-100 pool). The G-100 pool was dialyzed at pH 5.0 and fractionated by CM52 cellulose chromatography at pH 5.0. Recovery from CM52 cellulose columns was quantitative for protein and ranged 80-100 per cent for the nerve growth factor activity; the latter was almost completely carried by a protein which did not show any heterogeneity when examined by several analytical tests. The purified nerve growth factor showed an S(20,w) = 2.43, a D(20,w) = 7.30 and a 30,000 molecular weight. The over-all recovery was about 45 per cent.


Evaluation of esterases from livers of beef, pig, sheep, monkey and chicken for detection of some pesticides by thin-layer chromatographic-enzyme inhibition technique.


Ossification of a tuberculoma of cerebellum: report of a case.


Listeria monocytogenes endocarditis: a clinical and bacteriological report.


Microassay of hepatic UDP-glucuronyl transferase.


Quantitation of antigen in radial immunodiffusion plates.


Dependence of radial immunodiffusion of fibrinogen on time and antigen concentration.


Observations on a histaminase of invertebrate origin: a contribution to the study of cephalopod amine oxidases.


Response of monkey biorhythms to changing photoperiods.


Analog computer simulation of log(K)-pH profiles.


Communications. N-terminal residues of heavy chains of human IgA myeloma proteins.


Maintenance of venous polyethylene catheters to reduce risk of infection.


The ritualization of agonistic behavior as a determinant of variation along the neuroticism/stability dimension of personality.


A study of some disease hazards which could be associated with the system of applying cattle slurry to pasture.


Studies of vesical diverticula.

Studies of vesical diverticula.


An evaluation of gonorrhea case findings in the chronically infected female.


Effect of heparin, protamine sulfate and antigen on histaminase (diamine oxydase) activity of the guinea pig liver.


Action of some antibiotics on the extra-hepatic biliary tract. VI. Spiramycin.


Antagonism of prostaglandin E2 by 1-acetyl-2-(8-chloro-10,11-dihydrodibenz (b,f) (1,4) oxazepine-10-carbonyl) hydrazine (SC-19220).


Lipid synthesis in relation to the cell cycle of Bacillus megaterium KM and Escherichia coli. Lipid synthesis during the cell duplication cycle of Bacillus megaterium KM and Escherichia coli was studied by glycerol incorporation both in synchronized cultures and in unsynchronized exponentially growing populations subsequently fractionated according to size (and age). A large transient increase in the rate of incorporation per unit cell mass was observed around the time of cell division, probably reflecting the synthesis of the division septum.


Planning health services, American style.


Hydrolysis of penicillins and related compounds by the cell-bound penicillin acylase of Escherichia coli. 1. A method is given for the preparation of penicillin acylase by using Escherichia coli N.C.I.B. 8743 and a strain selected for higher yield. The enzyme is associated with the bacterial cells and removes the side chains of penicillins to give 6-amino-penicillanic acid and a carboxylic acid. 2. The rates of penicillin deacylation indicated that p-hydroxybenzylpenicillin was the best substrate, followed in diminishing order by benzyl-, dl-alpha-hydroxybenzyl-, 2-furylmethyl-, 2-thienylmethyl-, d-alpha-aminobenzyl-, n-propoxymethyl- and isobutoxymethyl-penicillin. Phenylpenicillin and dl-alpha-carboxybenzylpenicillin were not substrates and phenoxymethyl-penicillin was very poor. 3. Amides and esters of the above penicillins were also substrates for the deacylation reaction, as were cephalosporins with a thienylmethyl side chain. 4. For the deacylation of 2-furylmethylpenicillin at 21 degrees the optimum pH was 8.2. The optimum temperature was 60 degrees at pH7. 5. By using selection A of N.C.I.B. 8743 and determining reaction velocities by assaying yields of 6-amino-penicillanic acid in a 10min. reaction at 50 degrees and pH8.2, the K(m) for benzylpenicillin was found to be about 30mm and the K(m) for 2-furylmethylpenicillin, about 10mm. The V(max.) values were 0.6 and 0.24mumole/min./mg. of bacterial cells respectively.


Penicillins and other acylamino compounds synthesized by the cell-bound penicillin acylase of Escherichia coli. 1. The penicillin acylase of Eschericha coli N.C.I.B. 8743 is a reversible enzyme. Reaction rates for the two directions have been determined. 2. Measurements of the rates of enzymic synthesis of penicillins from 6-aminopenicillanic acid and various carboxylic acids revealed that p-hydroxyphenylacetic acid was the best substrate, followed by phenylacetic, 2-thienylacetic, substituted phenylacetic, 3-hexenoic and n-hexanoic acids. 3. The rate of synthesis of penicillin improved when amides or N-acylglycines were used; alpha-aminobenzylpenicillin and phenoxymethylpenicillin were only synthesized when using these more energy-rich compounds. 4. Phenyl-acetylglycine was the best substrate for the synthesis of benzylpenicillin compared with other derivatives of phenylacetic acid. 5. The enzyme was specific for acyl-l-amino acids, benzylpenicillin being synthesized from phenylacetyl-l-alpha-aminophenylacetic acid but not from phenylacetyl-d-alpha-aminophenylacetic acid. 6. alpha-Phenoxyethylpenicillin was synthesized from 6-aminopenicillanic acid and alpha-phenoxypropionylthioglycollic acid non-enzymically, but the rate was faster in the presence of the enzyme. 7. The E. coli acylase catalysed the acylation of hydroxylamine by acids or amides to give hydroxamic acids, the phenylacetyl group being the most suitable acyl group. The enzyme also catalysed other acyl-group transfers.


Some properties of cytochrome b5 from liver microsomes of man, monkey, pig and chicken. 1. Cytochrome b(5) was released from liver microsomes of man, monkey, pig and chicken by incubation with a crude lipase preparation. 2. By using DEAE-cellulose chromatography, ammonium sulphate fractionation, Sephadex-gel filtration and a final gradient elution on DEAE-Sephadex A-50, cytochromes b(5) were obtained from the four species studied, all possessing similar spectral properties. 3. Stokes radii of the cytochromes were measured by gel filtration. 4. N-Terminal amino acids for the different cytochromes were serine for man and monkey, alanine for pig and glycine for chicken. 5. Amino acid analyses of the cytochromes are presented. 6. Peptide ;fingerprint' patterns of tryptic digests of the different cytochromes are discussed and clearly show increasing similarity for more closely related species.


Some properties of two cell-bound beta-lactamases from Bacillus cereus 569-H.


Accumulation of inhibitors of protein synthesis after valine starvation. II. Effect on polyphenylalanine synthesis and the binding of phenylalanyl transfer RNA.


Enzymatic synthesis of carbonic anhydrases by human reticulocytes.


Interactions in vitro between gibberellins and DNA.


Effect of furanomycin on the synthesis of isoleucyl-tRNA.


Deoxyribonuclease-resistant DNA in the terminal stages of the RNA polymerase reaction.


Pseudo-inhibitor of aminoacyl transfer RNA formation from Bacillus subtilis.


Metal ions and ribosomal conformation.

Metal ions and ribosomal conformation.


Histidine decarboxylase in gastric mucosa of various mammals.


Proteinuria in the rat: a comparison of tissue components in the voided and renal pelvic urine.


Morphine as inhibitor of prostaglandin E1 on the isolated guinea-pig intestine.


Autoantibodies in cancine neoplasms. I. Reactivity of autologous 7S gamma-globulins with tumor cells.


Autoantibodies in canine neoplasms. II. Tumor tissue specificity and lack of cross-reactivity with embryonic antigens.


Observations on certain biological markers of dengue viruses. (With a note on the relationship between virus dose and survival time in mice).


Assessment of immuno-gel diffusion technique and fibrin degradation flocculation test in fibrinolysis investigations.


A serological study of anti-human globulin (Coombs) sera.


Modification of neurotoxicity of methylglucamine diatrizoate (hypaque 75 per cent) by intra-arterial instillation of vasoactive drugs.


Electrical properties of cells isolated from blastula stages of the South African toad Xenopus laevis.


Isolation and estimation of pure monkey serum kallikrein.


Does chagas' disease exist in Asia? (Further contribution to this problem).


Evaluation of chloramphenicol acid succinate therapy of induced typhoid fever and rocky mountain spotted fever.


Hereditary prothrombin deficiency.

Hereditary prothrombin deficiency.


Aegyptianella pullorum Carpano 1928--fine structure and taxonomy.


A note on the defence reactions of insects to Protozoa.


The blood picture resulting from Nuttallia (=Babesia) rodhaini and Nuttallia (=Babesia) microti infections in rats and mice.


Biosynthesis of mycobacillin, an antifungal peptide. IV. Effect of chloramphenicol isomers.


Localization of alkaline phosphatase isozymes in mouse duodenum by immunofluorescence microscopy.


Physical properties of the skull and their significance in the mechanism of the temporobasal fractures.


A method of analysis for the individual tetracyclines of a mixture in biological fluids.


The development of immunoproteins in the pre- and postnatal time.


The prognostic value of the electrocardiographic features of chronic Chagas' disease.


Development cycle and cytochemistry of the sporadic bovine encephalomyelitis agent in fathead minnow cell culture.


Transfer ribonucleic acids.

Transfer ribonucleic acids.


Sorption promotors in biopharmaceutics.

Sorption promotors in biopharmaceutics.


Myocardial changes and kidney transplantation. Lesions in patients receiving immunosuppressive therapy.


The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus.


Adsorption of vancomycin by sensitive and resistant organisms.


Regulation of synthesis of 2,3-dihydroxybenzoic acid in Bacillus subtilis by iron and a biological secondary hydroxamate.