The computer in the diagnosis of thyroid disease.


A practical compromise in bone scanning.


Low probability of allergic reaction to albumin microspheres.


Serum agglutinins to commercially prepared albumin.


Production and evaluation of a formalin-killed Chikungunya vaccine.


Activity in vitro of lymphocytes and macrophages in delayed hypersensitivity.


Characterization of immunoglobulin G anti-glomerular basement membrane antibodies eluted from kidneys of patients with glomerulonephritis. II. IgG subtypes and in vitro complement fixation.


Isolation and purification of a peptido-rhamnomannan from the yeast form of Sporothrix schenckii. Structural and immunochemical studies.


Spontaneous reoxidation of the subunits of immunoglobulin M (IgM).


Anti-neuraminidase antibody response in serum and nasal secretions following intranasal or subcutaneous inactivated A2-Hong Kong-68 influenza virus vaccine.


Antigenic competition between mouse thyroglobulin and bovine serum albumin demonstrated by adoptive transfer.


C3b inactivator of man. II. Fragments produced by C3b inactivator cleavage of cell-bound or fluid phase C3b.


Arthritis associated with induced rubella infection.


Precipitating antibody to group A streptococcal polysaccharide in humans.


Immunochemical studies on infectious mononucleosis. I. Isolation and characterization of heterophile antigens from hemoglobin-free stroma.


Degradation of human IgM by pepsin: characterization of a high molecular weight fragment.


Immunoglobulin D concentration in pregnant women.


Gene expression during outgrowth of Bacillus subtilis spores. The relationship between gene order on the chromosome and temporal sequence of enzyme synthesis.


Periodontitis in the baboon (Papio anubis).


Pharmacokinetics of fenclozic acid in animals and man.


An evaluation of early bone changes after the insertion of mental endosseous implants into the jaws of rhesus monkeys.


Intralingual injection site for emergency stimulant drugs.


The effect of different demineralizing agents on oral mucous membrane.


Suppression of food intake with intragastric loading: relation to natural feeding cycle. Rats were infused through chronically implanted intragastric tubes with 100 percent of their normal total daily food intake. The infusion was given either continuously over 24 hours or divided into discrete meals programed to simulate the rats' natural eating pattern. The same diet was also available for consumption by mouth. In neither case did the animals completely stop eating. During slow infusions excessive consumption ranged from 30 to 50 percent. During simulated meal infusion of the same total quantity of diet, they compensated far better, overeating by only 2 to 18 percent. Periodic filling of the stomach between scheduled meals was no more effective than a continuous slow infusion. Therefore, factors related to the natural feeding cycle make a significant contribution to the effectiveness of food in maintaining satiety and controlling food intake.


Molecular weight and amino acid composition of Macaca irus parotid alpha-amylase.


Pseudomonas aeruginosa: growth in distilled water from hospitals. Pseudomonas aeruginosa can grow relatively fast in distilled water obtained in hospitals and achieve high cell contaminations which remain stable for long periods of time. Cells grown in distilled water react quite differently to chemical and physical stresses than cells grown in standard laboratory culture media.


Pulmonary changes following treatment for hemorrhagic shock: saline versus colloid infusion.


Profundus tendon blood supply within the digital sheath.


Preserved composite tendon allografts: a comparative study of changes in length, elasticity, and anastomotic and lineal tensile strength.


Postoperative positive nitrogen balance: effects on wound and plasma protein synthesis.


Metabolic evaluation of high calorie alimentation in surgical patients.


The proteins of Japanese encephalitis virus.


Fate of parental phi X174-DNA upon infection of starved thymine-requiring host cells.


Influenza viral RNPs newly synthesized during the latent period of viral growth in MDCK cells.


RNA synthesis during bacteriphage SPO1 development. II. Some modulations and prerequisites of the transcription program.


The infection of Pseudomonas aeruginosa by RNA pilus phage PP7: the adsorption organelle and the relationship between phage sensitivity and the division cycle.


Control of DNA synthesis in Bacillus subtilis by phage phi e.


The effect of phage T4 infection on phospholipid hydrolysis in Escherichia coli.


Studies on the nature of acquired immunity against leukemia in guinea pigs.


Serum iron-binding capacity in pregnancy.


Microspectrophotometric and electron microscopic studies of bone marrow in hereditary sideroblastic anaemia.


Normal human red cells treated in vitro with cephalothin. A scanning electron microscope study.


Haemoglobin K Woolwich (alpha 2, beta 2 132 lysine leads to glutamine) in Ghana.


The kinetics of plaque-forming cells in experimental hypersplenism.


The effect of certain lipid substances on sickling.


Infant gavage feeding.

Infant gavage feeding.


Bone grafting in the body of the mandible. Report of cases.


Genetic linkage between a locus for 6-PGD and the Rh locus: evaluation of possible heterogeneity in the recombination fraction between sexes and among families.


Nosema juli n. sp., a microsporidian parasite in the millipede Diploiulus londinensis caeruleocinctus (Wood) (Diplopoda: Julidae).


Visual field defects after frontal eye-field lesions in monkeys.


Estrogen induction of LH release in the rhesus monkey.


Release of TSH by TRF infused directly into a pituitary stalk portal vessel.


The distribution of radioactivity following the administration of labeled thyrotropin-releasing hormone (TRH) in rats and mice.


Factors influencing the levels of the alkaline phosphatases in maternal serum and cord serum.


Growth of Pseudomonas pseudomallei & Ps. aeruginosa on petroleum fractions.


Detection of Brucella antibodies in the whey of cows & buffaloes by gel-precipitin test.


Occurrence of ascorbic acid in mycobacterium tuberculosis H 37 R v .


Ocular colobomas in domestic cats.

Ocular colobomas in domestic cats.


What is your diagnosis?

What is your diagnosis?


Body composition in the growing rat as affected by dietary lactose, calcium, buffering capacity and EDTA.


Subperiosteal or cortical cyst and intramedullary neurofibromatosis--uncommon manifestations of neurofibromatosis. A case report.


Viruslike particles in Drosophila: constant appearance in imaginal discs in vitro.


Effects of immunization on the LD50 of two pathogens of Galleria mellonella.


Aspects of the fine structure of symbiotes and related host tissues in nephridia of Allolobophora caliginosa typica (Annelida: Lumbricidae).


Development of Pleistophora sp. (Microsporidian) in eggs of the polychaete Armandia brevis.


Chemicals affecting the encapsulation of foreign material in an insect.


Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma.


Base-exchange reactions for the synthesis of phospholipids in nervous tissue: the incorporation of serine and ethanolamine into the phospholipids of isolated brain microsomes.


Neurologic disorders and liver disease.

Neurologic disorders and liver disease.


Social olfaction: a review of the role of olfaction in a variety of animal behaviors.


Self-punishment for responding by monkeys during extinction of discriminated avoidance: effects of previous stimulus change reinforcement.


Glucose absorption from the dialysis fluid during peritoneal dialysis.


Exophthalmus in chronic renal insufficiency.


Renal arteriovenous fistula following puncture biopsy. A hemodynamic and functional study in four cases.


Ultrastructure of the microvasculature in experimental cerebral infarction.


Degeneration and regeneration in teased nerve fibres. I. Leprous neuritis.


Von Recklinghausen's disease associated with multiple neurolemomas.


Scabies.

Scabies.


Metabolism of nitroglycerin in man: influence of phenobarbital.


Organic nitrates: tolerance at the level of the vascular smooth muscle.


Whole-body and regional brain distribution of diazepam in newborn rhesus monkeys.


Carbenicillin: activity in vitro and blood levels after intravenous administration.


IgM heavy chain fragments in Waldenström's macroglobulinemia.


Macular cherry-red spot, corneal clouding, and beta-galactosidase deficiency. Clinical, biochemical, and electron microscopic study of a new autosomal recessive storage disease.


Hypokalaemia as a consistent feature of fulminant meningococcal septicaemia.


Radical radiation therapy for cancer of the lung.


A clinical trial of pentazocine analgesia in acute myocardial infarction and acute coronary insufficiency.


Fiorinal with codeine as a postoperative analgesic in dental surgery.


Effect of guanethidine and reserpine on glucose tolerance.


A multi-center clinical evaluation of epicillin.


Angina prophylaxis by chewable isosorbide dinitrate.


A double-blind clinical study--DMSO for acute injuries and inflammations compared to accepted standard therapy.


Combined administration of thioridazine, nicotinic acid, and fluoxymesterone in the treatment of geriatric patients.


Combined intramuscular administration of depot fluphenazine and benztropinemesylate in chronic schizophrenic patients.


A pilot study of GP-45795 in chronic schizophrenics.


Tissue concentrations of antibiotic following oral doses of tetracycline phosphate complex.


Cognitive function in children with epilepsy.


The chemistry of the cell walls of rod mutants of Bacillus subtilis.


Thermoactinomyces sacchari sp. nov., a thermophilic actinomycete causing bagassosis.


Effects of ethionamide and isoxyl on mycolic acid synthesis in Mycobacterium tuberculosis BCG.


An electron microscopic study of the corpus cardiacum of adult Drosophila melanogaster and its afferent nerves.


The fine structural morphology of adrenal cortices of normal and stressed squirrel monkeys.


157 Dy-HEDTA for skeletal imaging.

157 Dy-HEDTA for skeletal imaging.


Prostaglandin-induced myometrial activity inhibited by progesterone.


Acquisition of human antigens by Schistosoma mansoni during cultivation in vitro.


The effect of some spasmolytic drugs on the choledocho-duodenal junction in man.


The effect of testosterone in pharmacological doses on plasma volume and on some serum proteins in patients with sickle cell anemia and in sexually impotent men.


Humeral fractures in monkeys.

Humeral fractures in monkeys.


Comparative studies on the adsorption of vitamin B 12  to intestinal mucosa homogenate of adult and unweaned rats.


A simple method for preparation of anti-Australia antigen serum.


The effect of disodium cromoglycate on nasal provocation tests in children with seasonal allergic rhinitis.


Plasmodium falciparum malaria. Ultrastructure of parasitized erythrocytes in cardiac vessels.


A study of inapparent infection in smallpox.


The use of therapeutic antibiotics as feed additives.


Antigenic compositions of enzyme-containing preparations of Bacillus subtilis origins.


Extended care.

Extended care.


Levels of care.

Levels of care.


Direct evaluation of pituitary thyrotopin reserve utilizing synthetic thyrotopin releasing hormone.


Separation of thyroxine-binding proteins in human serum at pH 7.4. II. Effect of pH and temperature on the bindng capacities of thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA).


Hemolytic anemia in agammaglobulinemic chickens: a model of "autoimmune" disease in immune deficiency.


Delayed hypersensitivity to ribosomal protein from BCG.


Procholeragenoid: an aggregated intermediate in the formation of choleragenoid.


Immunity to Hemophilus influenzae type b. I. The isolation, and some physicochemical, serologic and biologic properties of the capsular polysaccharide of Hemophilus influenzae type b.


Treatment of pulps of monkeys with vancomycin and calcium hydroxide.


Immunologic investigations of naturally occurring canine thyroiditis.


The lymphocytotoxic reaction: the mechanism of rabbit complement action.


A simple method for quantitation of haptens using "indirect" single radial immunodiffusion.


Mechanisms of passive sensitization. II. Presence of receptors for IgE on monkey mast cells.


The use of human F(ab') 2  fragments as blocking agents in the mixed lymphocyte reaction.


Presidential remarks to the A.M.A.

Presidential remarks to the A.M.A.


The radioisotope skeletal survey.

The radioisotope skeletal survey.


Kinetic studies of hyperimmune 7S globulins in allogenic rats bearing Walker 256 tumors.


A prospective study of closed pleural biopsies.


A unique combination of developmental defects.


Rheumatic polymyalgia. Long-term treatment with steroids.


'Progress' in the treatment and prevention of coronary heart disease.


The effects of ultraviolet on the eye.

The effects of ultraviolet on the eye.


Some observations on the genetics of isoniazid resistance in the tubercle bacilli.


A reference system for antigens of Mycobacterium tuberculosis.


Salivary IgA children with atopic diseases.


In vitro cultivation of exoerythrocytic stages of Leucocytozoon simondi.


The 1970 epidemic of diphtheria in San Antonio.


Increased circulating IgE in trichinosis.


Interdependence of age and alpha rhythmicity on epileptiform discharges and seizures.


Distribution of inhaled radionuclides in the respiratory tract.


Comparative metabolism of radionuclides in mammals. VI. Retention of 95 Nb in the mouse, rat, monkey and dog.


The relative utility of various methods of personnel monitoring in a nuclear medicine laboratory.


Nonvenereal transmission of gonococcal infections to children.


Feeding the low-birth-weight infant.

Feeding the low-birth-weight infant.


Liver and spleen scintigraphy in staging Hodgkin's disease.


Biological testing of antilymphocyte sera and globulin in the baboon.


"Intal" intake.

"Intal" intake.


Evidence for genetic transformation in blue-green alga Anacystis nidulans.


Ossifying spinal arachnoiditis.

Ossifying spinal arachnoiditis.


Hypothermia produced by nicotine perfused through the cerabral ventricles of the unanaesthetized monkey.


A quantitative electroencephalographic comparison of some benzodiazepines in the primate.


Preventing maternal sensitization to Rho antigen.


Spectral analysis of long eeg samples for comparative purposes.


Menstrual cycle of the baboon. I. Clinical features, vaginal cytology and endometrial histology.


Menstrual cycle of the baboon. II. Endometrial ultrastructure.


Serum haptoglobin in patients with ovarian malignancies.


Amniotic fluid fetal maturity score.

Amniotic fluid fetal maturity score.


Influence of chelating agents on utilization of calcium, iron and manganese by the chick.


The effect of repeated mumps skin tests on the induction of antibody.


Serologic abnormalities associated with L-dopa therapy.


Analyses of a 6.5 S cryoglobulin.

Analyses of a 6.5 S cryoglobulin.


Automated red cell antibody analysis. A parallel study. II. Identification of serological specificity.


The CDe rhesus gene complex; some considerations revealed by a study of a Danish family with an antigen of the Rhesus gene complex (C) D (e) defined by a 'new' antibody.


Slow virus diseases of the central nervous system.


Virus, cell surface, and self: lymphocytic choriomeningitis of mice.


Sensitivity of Pseudomonas aeruginosa to sulfamethoxazole.


Serum immunoglobulin levels in premature and full-term infants.


The antibacterial stability of chlorobutanol stored in polyethylene bottles.


Pathogenesis and pathologic changes of experimentally induced listeriosis in newborn pigs.


Hematologic changes associated with intravenous johnin testing in cattle.


Characteristics of some 100-year-old tissue serologically identified as ovine.


The financial cost of chronic childhood asthma.


Acute renal failure. Treatment without dialysis by total parenteral nutrition.


Long term prophylaxis of childhood asthma using cromolyn sodium.


Effects of radiation on populations of Drosophila melanogaster with different genetic structures. I. Changes in fitness and productivity.


Effects of radiation on populations of Drosophila melanogaster with different genetic structures. II. Temporal changes in the sex ratio.


Effects of radiation on populations of Drosophila melanogaster with different genetic structures. 3. Interaction with population size.


Effects of human alimentary secretions on  64 Cu diffusion in an in vitro system.


Evaluation of the role of nitrogen dioxide in the development of respiratory diseases in man.


The effect of mitomycin C on the pyocine typing patterns of hospital strains of Pseudomonas aeruginosa.


Utilization of glyoxylate by acetate-grown Bacillus megaterium KM.


Pure red cell aplasia and thymoma: loss of serum inhibitor of erythropoiesis following thymectomy.


Haemophilus vaginalis 594, a gram-negative organism?


Diabetic glomerulosclerosis in children.


Immunodiffusion studies on the myxoviruses. 3. Identification of the structural antigens of Myxovirus influenza A-PR8.


Effects of some metabolic inhibitors on the electrical potential difference and short-circuit current across the lens of the toad Bufo marinus.


Influence of intraocular pressure and trabeculotomy on aqueous outflow in enucleated monkey eyes.


Long-term care for the elderly: optimums, options and opportunities.


Postparalytic hemifacial spasm: pathogenetic problems.


Fatty acid-requiring mutant of bacillus subtilis defective in branched chain alpha-keto acid dehydrogenase.


Purification and properties of Bacillus subtilis nucleoside diphosphokinase.


Occurrence and biosynthesis of beta-glucuronidic linkages in heparin.


The characterization of a discrete series of low density lipoproteins in the disease, hyper-pre-beta-lipoproteinemia. Implications relating to the structure of plasma lipoproteins.


Estimation of blood phenylalanine from a dried blood spot using the Guthrie test.


Technology of a regional Guthrie test service. Investigations were undertaken to discover the effect and importance of technical factors in the Guthrie test and to determine the most satisfactory materials available. These findings were used in setting up the screening service for phenylketonuria for the South West Metropolitan Region.


Fate of polychlorinated biphenyls in dairy products processed from the milk of exposed cows.


Bovine secretory immune system.

Bovine secretory immune system.


Immunological response of cows to Brucella antigens.


The effect of lactated Ringer's solution on blood and urine levels of lactate isomers.


Inappropriate release of ADH in subdural hematoma.


Explosion fractures of the distal tibia with major articular involvement.


The Australian rifampicin trial.

The Australian rifampicin trial.


Ethyl methanesulfonate-induced mutations of the Sh1 protein in maize.


The proportion of complete mutations, mosaics and instabilities induced by ethylnitrosourea in Drosophila melanogaster.


Interaction of chromosome breaks in spermatids and spermatocytes of Drosophila melanogaster.


Identification of neisseria.

Identification of neisseria.


Unknown effects of viral vaccines.

Unknown effects of viral vaccines.


Metabolic implications of polymorphism as an adaptive strategy.


The effects of a tubercle bacillary lipid on lympho-reticular tissue and on the natural haemolysin to sheep red cells in the rabbit.


The 1971 Presidential Address.

The 1971 Presidential Address.


An evaluation of the techniques used for the detection of Australia antigen and antibody.


Oral iron with succinic acid in the treatment of iron deficiency anaemia. An evaluation based on measurements of iron absorption using a whole body counter and a double radioiron technique.


Release reaction in washed platelet suspensions induced by kaolin and other particles.


Radiobiologic determination of the total dose in radiotherapy.


Effect of single dose or fractionated proton irradiation on pulmonary tissue and Vx2 carcinoma in lung of rabbit.


Intestinal absorption of radioiodine labelled human serum albumin, mono-iodotyrosine and di-iodotyrosine following abdominal radiation therapy.


Radiation for immunosuppression in human organ transplantation. II. Clinical experience.


Dosimetric measurements at the nordic medical accelerators. I. Characteristics of the radiation beam.


Treatment of cancer of the vulva with high energy electrons.


Hydrops fetalis and stillbirth in a male glucose-6-phosphate dehydrogenase-deficient fetus possibly due to maternal ingestion of sulfisoxazole; a case report. A woman pregnant with her second child was given sulfisoxazole (Gantrisin) during her eighth month of pregnancy for a urinary tract infection.  Her 34-week-old male infant was stillborn with hydrops fetalis and severe anemia.  The mother was found to be glucose-6-phosphate-dehydrogenase (G-6-PDH) deficient.  Ingestion of the drug which is known to produce hemolysis in G-6-PDH-deficient people may have compromised the male infant by creating an abundance of bilirubin via massive hemolysis and also retarding its elimnation by competing with  bilirubin for albumin-binding sites.  This case identifies a newly recognized danger in the use of sulfonzmides in the third trimester of pregnancy.


A radioligand assay for plasma unconjugated estriol in normal and abnormal pregnancies.


Quantitative distribution of IgG, IgM and IgA immunoglobulins in lymphocytic thyroiditis of the Hashimoto type.


Growth and photosynthesis in an extreme thermophile, Synechococcus lividus (Cyanophyta).


Serological studies with Agrobacterium radiobacter, A.tumefaciens, and Rhizobium strains.


Irreversible change of the pattern of carcinogenic aminoazo dye-binding proteins in rat liver during continous feeding of 3'-methyl-4-dimethylaminoazobenzene.


The effects of phleomycin on mouse L-cells.


Children and youth projects and related comprehensive health care programs. Implications for the future.


Diagnosis of gonorrheal infection by culture of the external ear canal in the newborn.


Detection of snake venom in tissue.

Detection of snake venom in tissue.


Investigation on the denaturation effect of large doses of gamma rays upon the vegetal globulins isolated from sunflower seeds.


Experimental transplantates in diffusion chambers from thyroid gland after freezing and preservation at low temperatures.


Large hernia of the umbilical cord (omphalocele) in a child at the age of one day, operated in one stage.


Biological and immunochemical studies with growth hormone in pituitary extracts of holostean and chondrostean fishes.


Listeria monocytogenes meningo-encephalitis. (Report of a fatal case).


Evolutionary biology of prolactins and somatotropins. I. Electrophoretic comparison of tetrapod prolactins.


Bicarbonate requirement for elimination of the lag period of Hydrogenomonas eutropha. Carbon dioxide and oxygen concentrations have a profound effect on the lag period of chemoautotrophically grown Hydrogenomonas eutropha. Minimum lag periods and high growth rates were obtained in shaken flask cultures with a prepared gas mixture containing 70% H(2), 20% O(2), and 10% CO(2). However, excessively long lag periods resulted when the same gas mixture was sparged through the culture. The lag period was shortened in sparged cultures by decreasing both the pO(2) and the pCO(2), indicating that gas medium equilibration had not occurred in shaken cultures. The lag period was completely eliminated at certain concentrations of O(2) and CO(2). The optimum pO(2) was 0.05 atm, but the optimum pCO(2) varied according to the pH of the medium and physiological age of the inoculum. At pH 6.4, the pCO(2) required to obtain immediate growth of exponential, postexponential, and stationary phase inocula at equal specific rates was 0.02, 0.05, and 0.16 atm, respectively. With each 0.3-unit increase in the pH of the medium, a 50% decrease in the CO(2) concentration was needed to permit growth to occur at the same rate. The pCO(2) changes required to compensate for the pH changes of the medium had the net effect of maintaining a constant bicarbonate ion concentration. Initial growth of H. eutropha was therefore indirectly related to pCO(2) and directly dependent upon a constant bicarbonate ion concentration.


Molecular sieving by the Bacillus megaterium cell wall and protoplast. Passive permeabilities of the cell wall and protoplast of Bacillus megaterium strain KM were characterized by use of 50 hydrophilic probing molecules (tritiated water, sugars, dextrans, glycols, and polyglycols) which varied widely in size. Weight per cent uptake values (R(w)) were measured at diffusional equilibrium under conditions that negated the influences of adsorption or active transport. Plots of R(w) for intact cells as a function of number-average molecular weight ( M(n)) or Einstein-Stokes hydrodynamic radius ( r(ES)) of the solutes showed three phases: a protoplast uptake phase with a polydisperse exclusion threshold of M(n) = 0.6 x 10(3) to 1.1 x 10(3), r(ES) = 0.6 to 1.1 nm; a cell wall uptake phase with a polydisperse exclusion threshold of M(n) = 0.7 x 10(5) to 1.2 x 10(5), r(ES) congruent with 8.3 nm; and a total exclusion phase. Isolated cell walls showed only the latter two phases. However, it became evident that the cell wall selectively passed only the smallest molecules in a heterodisperse polymer sample. When the molecular-weight distributions of polyglycol samples ( M(n) = 1,000, 1,450, and 3,350) were determined by analytical gel chromatography before and after uptake by intact cells or isolated cell walls, a quasi-monodisperse exclusion threshold was obtained corresponding to M(n) = 1,200, r(ES) = 1.1 nm. The permeability of isolated protoplasts was assessed by the relative ability of solutes to effect osmotic stabilization. An indefinite exclusion threshold, evident even with monodisperse sugars, was attributed to lengthwise orientation of the penetrating rod-shaped molecules. Altogether, the best estimate of the limiting equivalent porosity of the protoplast was 0.4 to 0.6 nm in radius and of the cell wall, 1.1 nm.


Isolation and characterization of a phosphatidylethanolamine-deficient mutnt of Bacillus subtilis. A mutant of Bacillus subtilis ATCC 6051 deficient in phosphatidylethanolamine, an important membrane lipid, was isolated by a combination of nitrosoguanidine mutagenesis and penicillin concentration of auxotrophs employing phosphatidylethanolamine as a supplement. The mutant was compared to the parent strain with regard to lipid composition, growth, osmotic fragility, and staining character and differed substantially in each category. In addition to scant amounts of phosphatidylethanolamine, the mutant contained phosphatidylglycerol, cardiolipin, lysyl phosphatidylglycerol, and diglucosyldiglyceride, though in amounts differing from those found in the parent strain. The mutant was unable to grow appreciably on synthetic media, had enhanced osmotic fragility of protoplasts, and resisted decolorization in staining.


Unusual effects of reducing agents on 0-diphenoloxidase of Mycobacterium leprae. Reducing agents had no effect on the oxidation of 3,4-dihydroxyphenylalanine (DOPA) to quinone by Mycobacterium leprae; no quinone formation by o-diphenoloxidase of mammalian or plant origin was detected under similar experimental conditions. Ascorbic acid and reduced glutathione prevented further oxidation and polymerization of the quinone to melanin by M. leprae; cysteine was less effective. In the presence of reducing agents, the quinone (indole-5,6-quinone) formed from DOPA by M. leprae was not reduced back to diphenol. On the other hand, the quinone (dopachrome) produced from DOPA by mammalian or plant phenolase was rapidly decolorized by reducing agents. Oxidized glutathione and cystine had little effect on o-diphenoloxidase from all of the three sources. Cyanide, which completely inhibited mammalian and plant phenolases, had only a partial effect on the enzyme in the bacilli. Various lines of evidence suggest that the properties of o-diphenoloxidase in M. leprae are different from those of similar enzymes obtained from other sources.


Citrate cycle and related metabolism of Listeria monocytogenes. The growth response of Listeria monocytogenes strains A4413 and 9037-7 to carbohydrates was determined in a defined medium. Neither pyruvate, acetate, citrate, isocitrate, alpha-ketoglutarate, succinate, fumarate, nor malate supported growth. Furthermore, inclusion of any of these carbohydrates in the growth medium with glucose did not increase the growth of Listeria over that observed on glucose alone. Resting cell suspensions of strain A4413 oxidized pyruvate but not acetate, citrate, isocitrate, alpha-ketoglutarate, succinate, fumarate, or malate. Cell-free extracts of strain A4413 contained active citrate synthase, aconitate hydratase, isocitrate dehydrogenase, malate dehydrogenase, fumarate hydratase, fumarate reductase, pyruvate dehydrogenase system, and oxidases for reduced nicotinamide adenine dinucleotide and reduced nicotinamide adenine dinucleotide phosphate. The alpha-ketoglutarate oxidation system, succinate dehydrogenase, isocitrate lyase, and malate synthase were not detected. Cytochromes were not detected. The data suggest that strain A4413, under these conditions, utilizes a split noncyclic citrate pathway which has an oxidative portion (citrate synthase, aconitate hydratase, and isocitrate dehydrogenase) and a reductive portion (malate dehydrogenase, fumarate hydratase, and fumarate reductase). This pathway is probably important in biosynthesis but not for a net gain in energy.


Phospholipid metabolism in the absence of net phospholipid synthesis in a glycerol-requiring mutant of Bacillus subtilis. A glycerol-requiring auxotroph of Bacillus subtilis showed no net synthesis of phospholipid when deprived of glycerol. Although there was no net synthesis of phospholipid, we found that: (i) fatty acids and (32)P were slowly incorporated into phospholipid; (ii) in pulse-chase experiments, both (32)P and (14)C in the glycerol portion of the phospholipids were lost from phosphatidlyglycerol (PG) and lysylphosphatidylglycerol and accumulated in cardiolipin (CL); (iii) the proportions of the phospholipids in the membrane changed with a loss of PG and an accumulation of CL. The addition of glycerol to the glycerol-deprived cells resulted in a rapid incorporation of glycerol and restoration to the predeprivation metabolism and PG to CL ratio.


Protease activities during the course of sporulation on Bacillus subtilis. Three proteolytic enzymes have been isolated from sporulating cultures of Bacillus subtilis. These activities were, respectively, a protease inhibited by ethylenediaminetetraacetic acid (EDTA) but not phenylmethylsulfonyl fluoride (PMSF), a protease active on both protein and ester substrates, and an ester-active enzyme with low activity on proteins. The latter two enzymes were inhibited by PMSF but not by EDTA. The specific activity of each was determined both intra- and extra-cellularly during growth and sporulation in a single-defined medium. All three enzymes were shown to exhibit a rapid increase in specific activity at a time coinciding with the appearance of refractile bodies in cells.


Bacterial inactivation of transforming deoxyribonucleate. Competent and noncompetent bacteria are able to bind deoxyribonucleate (DNA). The consequence of this binding is different for the two types of bacteria. Competent bacteria are able to utilize the DNA for transformation. DNA exposed to noncompetent bacteria loses its biological activity with a coincident reduction in the double-stranded molecular weight. The reduction in molecular weight does not appear to be sufficient to account for the loss of biological activity observed.


Evaluation of ankle injury.

Evaluation of ankle injury.


Calling our own shots.

Calling our own shots.


President Nixon's freeze and health care economics.


Human-baboon cross-circulation for treatment of hepatic coma.


Detection of Australia antigen in various fractions of frozen blood.


Effects of amphetamine and chlorpromazine on second-order escape behavior in squirrel monkeys.


WHO's work in cardiovascular diseases: a brief review.


Telemetering pressure and flow from the pulmonary circulation of the intact, free-ranging animal.


Benign orbital neurilemoma. Sarcomatous transformation in von Recklinghausen's disease.


Middle ear epithelium of squirrel monkey.


Disputed parentage.

Disputed parentage.


Platelet transfusions.

Platelet transfusions.


Striate cortex-superior colliculus projection in squirrel monkey.


Influence of the population genetic background on the persistency of a recessive lethal in Drosophila melanogaster.


Environmental influences on puffing in the salivary gland chromosomes of Drosophila melanogaster.


Gene conversion in higher organisms: non-reciprocal recombination events at the rosy cistron in Drosophila melanogaster.


Chromosome transfer in Pseudomonas aeruginosa mediated by R factors.


Comparative metabolism of radionuclides in mammals. VII. Retention of  106 Ru in the mouse, rat, monkey and dog.


A human radioactivity counter and medical van.


Planning models for tuberculosis control programs.


Average length of stay in long-term institutions.


Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. The effect of oral administration of antibiotics on the intestinal flora of conventional mice and their resistance to colonization by orally introduced Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa was studied. Colonization resistance (CR) was expressed as the log of the oral bacterial dose followed by a persistent take in 50% of the contaminated animals. The intestinal flora was virtually eliminated by the antibiotics and this elimination was accompanied by a precipitous fall of CR. CR gradually returned to normal values during the period of repopulation of the intestinal tract by the organisms surviving the treatment. Antibiotic treatment resulted in the disappearance of Enterobacteriaceae, enterococci, staphylococci and yeasts and, under appropriate housing conditions, the animals remained free of these organisms indefinitely. Germ-free mice contaminated with the intestinal flora of an antibiotic-treated animal and their offspring housed in a germ-free isolator showed high values of CR. Their intestinal flora consisted of anaerobic bacteria only. Apparently, these anaerobes are responsible for CR in these and in conventional mice.


Adenomyomatosis and prominent Aschoff-Rokitansky sinuses of the gallbladder.


Effects of anticoagulants and containers (glass and plastic) on the blood count.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 45-1971.


Reduction of copper (II) in fungal laccase by hydrated electrons.


The nature and measurement of radioactivity.


Chicken serum proteins: comparison of electrophoretic techniques and localization of transferrin.


Cholestatic phenomenon in hepatic allograft rejection in the primate.


Renal and skin xenografts from baboons to macaques: effect of antilymphocyte globulins.


Primate cephalic transplantation: neurogenic separation, vascular association.


Successful 24-hour experimental kidney preservation.


Autoperfusing heart-lung preparation: prolonged survival by extracorporeal symbiosis.


Prolonged rhesus skin allograft survival produced by antihuman thymocyte serum.


Increasing effectiveness of antilymphocytic globulin by prevention of antibody formation to horse IgG.


Glomerular damage after intravenous administration of antilymphocyte globulin (ALG) in man and rhesus monkeys.


Immunosuppression by antihuman lymphocyte globulin: correlation of human and animal assay systems with clinical results.


Antithymocyte antisera theapy in nonsurgical immunologic disease.


In vitro stimulation or inhibition of lymphocyte activation by antilymphocyte serum.


Congenital diverticulum of the right ventricle. Association with pulmonary stenosis and ventricular septal defect.


Structural proteins of adenoviruses. VII. Purification and properties of an arginine-rich core protein from adenovirus type 2 and type 3.


Prophylaxis of maternal RH-sensitization by means of anti-D immunoglobulin.


Apparent serologic reaction between bacterial cell components and blood components.


The role of bacterial antagonism and isoantagonism in the pattern of infection in chronic osteitis.


The occurrence of Co ++ -activated acylase in animal tissues.


Toxicity of carbamates for mammals.

Toxicity of carbamates for mammals. Toxicity studies have been carried out with a number of monomethylcarbamates, most of which reached an advanced stage in the World Health Organization insecticide evaluation programme. Both quantitative and qualitative distinctions have been found between the carbamates studied, and certain common characteristics that distinguish them in several important aspects from organophosphorus insecticides have been demonstrated.


Biological and nonbiological modifications of carbamates. Methylcarbamate insecticides undergo hydrolysis, oxidation, dealkylation, and conjugation in animals, plants, and insects to form similar or identical products. Carbaryl is hydroxylated in biological systems to form hydroxy, dihydro-dihydroxy, and N-hydroxymethyl carbaryl and is hydrolysed to form 1-naphthol. The products are conjugated, stored, or excreted. Carbofuran is hydroxylated at the 3 position and propoxur at the 5 position to form hydroxylated derivatives. N-hydroxymethyl derivatives of these two carbamates may also be formed. Hydrolysis appears to be the major metabolic pathway of carbofuran in the animal. Aldicarb is oxidized to its sulfoxide and then hydrolysed to the oxime sulfoxide in animals and plants. Plants hydrolyse the oxime sulfoxide to form the corresponding aldehyde, which is an intermediate in the formation of 2-methyl-2-(methyl-sulfinyl)propanol. Methomyl, which is structurally similar to aldicarb, is metabolized in plants to acetonitrile, carbon dioxide, and methylamine. Bux and Meobal undergo hydrolysis and hydroxylation to form N-hydroxy methylcarbamates, as well as hydroxybutylphenyl and hydroxymethylphenyl methylcarbamates. Zectran, which contains a dimethylamino group, is converted to the methylamino, amino, and methylformamido derivatives by insects and plants. In soil and water, methylcarbamate insecticides are hydrolysed to their respective phenols or oximes.


Species specificity of phosphate triester anticholinesterases. Two widely distributed enzyme systems degrade phosphate triester anticholinesterase agents to inactive phosphate diesters by nonhydrolytic mechanisms. The substrate specificity of these enzymes is discussed and the level of activity in various mammalian livers is described. The distribution of these enzymes is an important factor in accounting for the species specificity of at least some anticholinesterase agents.


The effects of MP virus infection in lymphoma.


Distribution and determination of cholinesterases in mammals. This paper reviews the distribution of cholinesterases in the central nervous system, the ganglia, the striated muscle, and the blood of mammals, and discusses the correlation between the histochemical localization and the function of neuronal cholinesterase.Different methods for the determination of cholinesterase levels are reviewed, with particular reference to their practical value for field work. The Warburg method and the Tintometer and Acholest colorimetric methods are compared on the basis of cholinesterase levels determined in normal persons and in those suffering from parathion intoxication.


Pneumoconioses among the workers from the metal working enterprises--Plovdiv.


Selective angiography of A. coeliaca in cirrhoses with splenomegalic syndrome.


Reutilization of amino acids in protein synthesis in HeLa cells.


Bacilli in milk. 2. Sweet curd formation.


Synthesis and degradation of malic enzyme in chick liver.


Laboratory tests for hepatitis-associated antigen.


Spore removal by centrifugation and its effect on ultra-high temperature commercial sterilization of milk.


Studies on hepatic polyribosomes and protein synthesis in rats force-fed a protein-free diet.


Effect of iron on lipid metabolism of Tetrahymena pyriformis.


The induction by x-rays of double mosaics involving the Y-chromosome, supporting first cleavage segregation in Drosophila melanogaster.


The genetics of chemotaxis in Drosophila melanogaster: selection for repellent insensitivity.


Ossifying fibromas of the frontal-ethmoid sinuses.


A functional assessment of an isolated liver-kidney perfusion system.


The occurrence of whirling disease (myxosomiasis) in Norway.


Residues of polychlorinated biphenyls (PCB) and organochlorine insecticides in liver tissue from terrestrial Danish predatory birds.


Lipoprotein analysis: a comparative study.


Immunological determination of hemopexin in human serum.


Transvaginal human sterilization: a preliminary report.


The inhibition of mitochondrial respiration and oxidative phosphorylation by serum from malaria-infected animals. II. The inhibitory activity of serum ultrafiltrates from Plasmodium knowlesi-infected monkeys.


The inhibition of mitochondrial respiration and oxidative phosphorylation by serum from malaria-infected animals. 3. Sephadex separation of inhibitory serum ultrafiltrates from Plasmodium knowlesi-infected monkeys and Plasmodium berghei-infected mice.


Bovine babesiasis: estimation of infection rates in the tick vector Boophilus microplus (Canestrini).


Experimental transmission of Trypanosoma gambiense to domestic animals.


Enzootic cutaneous leishmaniasis in Eastern Panama. I. Investigation of the infection among forest mammals.


Ultrasonic synergistic effects in liquid-phase chemical sterilization. New methods of sterilization employing a chemical with moderate heat and ultrasonic energy have been devised. Inactivation of high-density bacterial spore suspensions is achieved by treatment with low concentration aqueous acid glutaraldehyde solutions at temperatures above or about 54 C. Low (20 kHz) or high (250 kHz) frequency ultrasonic energy is synergistic with glutaraldehyde. Rapid inactivation may also be achieved by using ultrasonic energy and aqueous alkalinized glutaraldehyde solutions at low (25 C) or moderate (55 C) temperatures. If compared to present room temperature techniques, "surface sterilization" time for contaminated objects can be reduced from hours to minutes.


Streptomyces torulosus sp. n., an unusual knobby-spored taxon. Several strains of a streptomycete with unusual spore wall ornamentation were isolated from Iowa soils. They are further characterized by coiled chains of spores, gray aerial mycelium, melanin-like pigments, and the production of antibacterial and antifungal antibiotics. Spore wall ornamentations, as seen with the transmission electron microscope, do not correspond with any of the four generally recognized categories of spore wall ornamentation-smooth, warty, spiny, or hairy-but seem to represent an intermediate position between warty and spiny. This unusual ornamentation consists of blunt projections rising out of an otherwise smooth surface and is termed "knobby." To obtain further information on the nature of the knoblike projections and their possible status in representing a defined spore wall ornamentation category, scanning electron micrographs and transmission electron micrographs representing all sporewall ornamentation categories were compared. Differentiation between the several categories was more difficult with the scanning electron microscope than with the transmission electron microscope.


Effect of relative humidity and temperature on airborne Venezuelan equine encephalitis virus. Inactivation of airborne Venezuelan equine encephalitis (VEE) virus disseminated from liquid suspensions or from lyophilized preparations as 1- to 5-mum particles was investigated under various conditions of relative humidity and temperature in a 2,500-liter static aerosol chamber. Relative humidity ranging from 18 to 90% at 24 C and temperature ranging from -40 to 24 C had no marked effect on the biological decay rate or the recovery of viable airborne VEE virus disseminated from liquid suspensions. However, at 49 C a significant increase in the biological decay rate and decrease in aerosol recovery of the VEE virus were observed. Airborne lyophilized VEE virus was significantly affected by relative humidity. An increase in relative humidity from 20 to 90% resulted in progressive decrease in aerosol recovery of viable VEE virus. A twofold reduction in aerosol recovery of the lyophilized virus was observed at and above 29 C as compared to the lower temperatures studied. However, the differences among biological decay rates of lycphilized VEE virus were not significant within temperature range of -40 to 38 C.


Analysis of staphylococcal enterotoxin B by the polyacrylamide electrophoresis technique. The electrophoretic mobility of enterotoxin B was investigated through the use of the disc electrophoresis technique. Ideal patterns were developed with a 7.5% acrylamide gel system (pH 4.3). The toxin can be separated and identified from other complex proteins such as serum or suspect samples of foods by this technique. The technique can be used as an assay method for the toxin as well as to elucidate physical changes in the toxin due to temperature. The method should not be considered exclusive for enterotoxin B.


Surface decontamination in an autoclave chamber with formaldehyde gas. A simple device for the conversion of a standard steam autoclave into a formalde-hyde gas sterilization chamber is described.


Quantitative genetic variation in carbonic anhydrase isozymes from tissues of the pig-tailed macaque, Macaca nemestrina.


Beta hemolysin: a persistent impurity in preparations of staphylococcal nuclease and enterotoxin. Purified staphylococcal nuclease and enterotoxin B from several sources contained beta hemolysin whose physicochemical resemblances to the other two proteins make its elimination difficult.


Kinetics and thermodynamics of the reactions of acyl-papains. Effects of pH, temperature, solvents, ionic strength, and added nucleophiles.


Comparative study of appearance of water-soluble antigens and brain esterase fractions in ontogenesis of two strains of rats.


Monosaccharides as specific precipitinogens of eel anti-human blood-group H(O) antibody.


Initiation of spore germination in Bacillus cereus: a proposed allosteric receptor.


Essentials in the management of juvenile diabetic ketoacidosis.


A prospect of computer implementation of radiotherapy.


The pathology of tumors, part three: frozen section, gross and microscopic examination, ancillary studies.


The changing patterns of cervix cancer.

The changing patterns of cervix cancer.


Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia. The distribution of peripheral blood lymphocytes that contain surface Ig has been studied by means of immunofluorescence in humans. Normal individuals, individuals with sex-linked and acquired agammaglobulinemia, selective IgA deficiency, cellular immune deficiencies, and individuals with chronic lymphatic leukemia (CLL) were studied. Approximately 28% of the peripheral blood lymphocytes from normal individuals contained surface Ig. On an average 15% contained IgG, 6%, IgA, and 8%, IgM; and the kappa: lambda ratio was 2:1. Lymphocytes from patients with CLL appeared to be "monoclonal" in that the cells from a given individual had a single Ig associated with them (e.g., kappa IgM). In three-quarters of the cases the H chain class was IgM; in the remaining one-quarter no H chain could be detected on the cell surface. The L chain class was kappa in 12 cases and lambda in 8. Four patients with sex-linked agammaglobulinemia and one with "acquired" agammaglobulinemia had markedly decreased numbers of cells with surface Ig (0-4%). In contrast, the three patients with selective IgA deficiency and no detectable serum IgA contained normal numbers of cells (6-8%) with surface IgA. Five patients with cellular deficiency states, including two with Wiskott-Aldrich syndrome, contained a normal or low percentage of cells with surface Ig.


Effect of carbon dioxide inhalation on the pattern of gaseous metabolism in ischaemic zones of the primate cortex. An experimental study of the 'intracerebral steal' phenomenon in baboons. The cortical circulation of the baboon has been studied during ischaemia produced by middle cerebral occlusion. Evidence of reactive hyperaemia did not occur in hypercapnia. Metabolic studies as a whole present evidence of increased interference with gaseous metabolism during hypercarbic occlusion, despite raised venous pO(2) during hypercarbia. The significance of these findings is discussed.


Enzymatic characteristics of the monkey endometrium during ovulatory and anovulatory cycles and under hormonal contraception treatment.


Sir James Paget (1814-1899).

Sir James Paget (1814-1899).


Isomers of alpha-tocopheryl acetate and their biological activity.


Radionuclidic imaging procedures in the diagnosis of cancer.


Distribution and metabolism of two orally administered esters of tocopherol.


Unproven methods of cancer management: Contreras methods.


The Rhesus factor in pregnancy.

The Rhesus factor in pregnancy.


Treatment of Listeria monocytogenes meningitis.


Acute hypokalemia occurring during the treatment of diabetic acidosis.


Presidential address.

Presidential address.


Prevention of Rh sensitization. Report of a WHO Scientific Group.


Mast cells in human peripheral nerve.

Mast cells in human peripheral nerve.


An unusual case of aberrant pancreas in the stomach. A roentgenographic and gastrophotographic demonstration.


Doxycyclinum NFN: a pharmacological and bacteriological investigation.


Intramural lesions of the gallbladder.

Intramural lesions of the gallbladder.


Cutaneous streptococcal infections in Vietnam.


Epiglottitis in adults.

Epiglottitis in adults.


Average weekly wages and the cost of medical care.


Chondrosarcoma of the maxilla. Report of a case responding to supervoltage irradiation and review of the literature.


Detection of monomeric IgM by acrylamide disc gel electrophoresis followed by agar gel immunodiffusion.


Differential fluorescent staining of Drosophila chromosomes with quinacrine mustard.


Calcium and chelate loading tests in evaluation of hormonal regulation of plasma calcium level in various patients.


Influence of constant light on the hypothalamic regulation of pituitary function in the baboon.


Meningitis due to a group A sulfonamide-resistant Meningococcus in Ethiopia.


Penicillin sensitivity of Neisseria gonorrhoeae isolated in Addis Ababa.


Menstrual disturbances after interruption. Of 148 women in Bulgaria who were aborted by curettage, 54% had a delay of the first postoperative menstrual period.  In over 30% of the patients, there was menorrhagia.  In a large portion of the women, the successive menstruations were changed in duration or in quantity.  A statistical comparison with changes in menstruation after vacuum aspiration shows fewer instances of prolongation of menstruation, abundant menstruation, more painful menstruation or changes in the periods.  All differences between vacuum and curettage are highly significant.


A case of atypical hernia in infancy.

A case of atypical hernia in infancy.


Double leptospira-carrying in a single individual of Micromys minutus.


A radiotracer assay for carbonic anhydrase.


The fine structure of the mycetome symbiotes of the aphids Brevicoryne brassicae, Myzus persicae, and Macrosiphum rosae.


Polycystic kidneys associated with malformations of the brain, polydactyly, and other birth defects in newborn sibs. A lethal syndrome showing the autosomal-recessive pattern of inheritance.


Rh immunization following incompatible blood transfusion and a possible long-term complication of anti-D immunoglobulin therapy.


X-linked spondyloepiphyseal dysplasia tarda: clinical and linkage data.


Feto-tumor serum antigens. Serologic studies with the Walker 256 tumor-rat model.


Discharge characteristics of single units in superior colliculus of the alert rhesus monkey.


A rapid safe technique for removal of a large vesical diverticulum.


Trenimon-induced chromosomal damage in bone-marrow cells of six mammalian species, evaluated by the micronucleus test.


The toxicity of parenteral iron preparations in the rabbit and pig with a comparison of the clinical and biochemical responses to iron-dextrose in 2 days old and 8 days old piglets.


Pathological changes in experimental copper poisoning in chickens.


Effect of age at first calving and first lactation yield on life time production in Italian buffaloes.


Sinus paranasalis of the Egyptian buffalo, Bos(Bubalus)bubalis L.


In vitro and in vivo effects of cadmium chloride on isoenzymes of carbonic anhydrase in rat testes and erythrocytes.


Culture of two- and four-cell rabbit embryos to the blastocyst stage in serum and serum extracts.


A comparative study of the effects of electrosurgery and cryosurgery in the management of benign oral lesions.


Neurofibromatosis with leukaemia.

Neurofibromatosis with leukaemia.


The validity of measurement of mean whole body intracellular hydrogen ion activity using 5,5-dimethyl-2,4-oxazolidinedione.


Iron metabolism in patients with chronic renal failure on regular dialysis treatment.


Saturnism, pediatric and adult lead poisoning.


Recent advances in techniques for freezing red cells.


Antigen development in neonatal rat liver.


Synthesis of stage specific serum proteins and tissue antigens by early neonatal rat liver.


Macronuclear development in Euplotes woodruffi following conjugation.


The mucocysts of Tetrahymena pyriformis: localization of the TCA-ethanol-soluble protein.


A semi-quantitative method for determining the levels of carbonic anhydrase isozymes in individual red blood cells.


Mutants of Pseudomonas aeruginosa bblocked in nitrate or nitrite dissimilation.


Salivary chromosome bands and the frequency of crossing over in Drosophila melanogaster.


The effects of some physical and biotic environments on heterosis of direct and associate genotypes in Drosophila melanogaster.


Pseudomonas infections in man and animals.


Effects of nitroglycerin on regional myocardial blood flow in coronary artery disease. Regional myocardial blood flow before and after sublingual nitroglycerin was measured in 10 patients with coronary artery disease. During thoracotomy, (133)Xe was injected directly into the subepicardium in diseased regions of the anterior left ventricular wall, and washout rates were recorded with a scintillation counter. All disappearance curves were closely approximated by two exponential decays analyzed as two parallel flow systems by the compartmental method. The appearance of a double exponential decay pattern in diseased regions suggests that the slow phase was associated with collateral blood flow, although nonhomogeneous myocardium-to-blood partition coefficients for xenon cannot be excluded. Nitroglycerin increased the rapid phase flow in 9 of 10 patients and the slow flow in 7 of 10 patients. Average flow increased in 9 of the 10 patients (P < 0.01). Mean rapid phase flow in the control state was 110 ml/100 g per min and after nitroglycerin increased to 132 ml/100 g per min (P < 0.01); slow phase flow increased from 12 ml/100 g per min to 15 ml/100 g per min (P < 0.05). It is concluded that, under these conditions, nitroglycerin improves perfusion in regions of diseased myocardium in patients with coronary artery disease.


Tyrosinase isolated from mouse melanoma melanosome.


Left ventricular performance and coronary flow after coronary embolization with plastic microspheres. Coronary flow, left ventricular circumference, and left ventricular pressure were observed in the isovolumically contracting, isolated canine heart supported with arterial blood from a donor. Systolic pressure, heart rate, and coronary perfusion pressure were held constant while the coronary bed was progressively embolized with either large (average 865 mu) or small (average 10 mu) polystyrene microspheres. During embolization with large microspheres, coronary flow diminished progressively. After sufficient embolization, decreased ventricular performance was indicated by a rise in end-diastolic pressure. During embolization with small microspheres, coronary flow initially increased, which suggests the effective release of a vasodilator substance. Return of coronary flow to control levels occurred only after the end-diastolic pressure rose, on the average, to above 30 mm Hg. After embolization with both sizes of microspheres, ventricular diastolic pressure-volume relationships showed decreased ventricular compliance. This was attributed, in part, to edema of the ventricular wall and, in part, to focal shortening of the sarcomeres where the circulation was compromised. Embolization with both sizes of microspheres ultimately caused a decrease in ventricular performance, although when the systolic pressure was increased the usual relationship between peak developed wall stress, and end-diastolic pressure showed less of a descending limb than that found in the nonembolized, isolated heart. It is felt that the data summarized above have bearing on ventricular performance and coronary flow in clinical situations where hearts are perfused through pump oxygenator systems and are thereby subject to embolization from aggregated clumps of platelets and fibrin.


Transferable drug resistance.

Transferable drug resistance.


Changes in body temperature of the unanaesthetized monkey produced by sodium and calcium ions perfused through the cerebral ventricles. 1. In the unanaesthetized Rhesus monkey, solutions containing sodium, calcium, potassium or magnesium in excess of the normal concentration of extracellular fluid were perfused from a lateral to the fourth ventricle through chronically implanted cannulae.2. Sodium (11.0-88.0 mM in excess of the physiological concentration) perfused through the ventricles, caused an immediate rise in body temperature which was accompanied by vasoconstriction, piloerection and shivering. The latency of the hyperthermia was related directly to the rate of perfusion and the concentration of sodium, whereas the magnitude of the response depended upon the concentration only. When the perfusion was terminated, shivering ceased and the temperature of the monkey returned to the base line level.3. When calcium ions were perfused in concentrations 2.5-47.9 mM in excess of that of extracellular fluid, a fall in the temperature of the animal occurred. The magnitude of the decreases depended upon the concentration of calcium in the perfusion fluid. Vasodilatation, sedation and a reduction in withdrawal reflexes accompanied the calcium-induced hypothermia. After the perfusion ended, the temperature continued to fall until the monkey began to shiver and vasoconstriction was observed in many skin areas.4. The perfusion through the cerebral ventricles with modified Krebs solution alone or with the Krebs solution which contained potassium or magnesium ions in concentrations five to ten times normal had virtually no effect on the temperature of the monkey.5. Since the temperature of the monkey was unchanged as long as the physiological ratio of sodium to calcium in the perfusion fluid remained constant, we conclude that the balance between these two essential cations within the brain stem could determine the neural mechanism whereby the set-point for body temperature of the primate is established.


Experience with disodium cromoglycate in the treatment of asthmatic children.


Inhibition of triiodothyronine (T3) binding to thyroxine-binding globulin by sodium salicylate and its application to immunoassay of T3 in human serum.


Nature of the nerve lesion caused by a pneumatic tourniquet.


Temporal distribution of equine arteritis virus in respiratory mucosa, tissues and body fluids of horses infected by inhalation.


Dimethyl sulphoxide in the low-temperature preservation of Babesia bigemina.


Radiochemistry of macroaggregated albumin and newer lung scanning agents.


Exo-erythrocytic schizogony of Plasmodium vivax in Aotus monkeys.


The effect of steroid hormones on self-stimulation, central and peripheral.


Electron cytochemical study on glucose-6-phosphate dehydrogenase activity in erythrocytes of Aotus monkeys infected with Plasmodium falciparum.


A rapid method for the complete removal of white cells from large batches of monkey blood infected with the trophozoite- and schizont-stages of Plasmodium knowlesi.


Non-ultrafiltrable inhibitory substances in serum from P. knowlesi-infected monkeys.


1. Metabolic studies on a chloroquine-resistant P. berghei derived from a sensitive strain. 2. Further studies on the carbohydrate metabolism of malaria parasites.


Action of some antimalaria compounds against Plasmodium berghei in vitro.


Blood parasites of scaly-tailed flying squirrels in the Ivory coast.


A microsporidan infection of Lacerta muralis.


The effects of cordycepin on malaria parasites.


Chemistry and specifications of pesticides. Nineteenth report of the WHO Expert Committee on Insecticides.


Prostaglandin inhibition with a dibenzoxazepine hydrazide derivative and morphine.


Prostaglandin antagonism by polymeric phosphates of phloretin and related compounds.


Synthesis and biological activity of prostaglandins and prostaglandin antagonists.


Extraluteal effects of prostaglandins.

Extraluteal effects of prostaglandins.


Prostaglandin induction of luteolysis.

Prostaglandin induction of luteolysis.


Action of prostaglandin in the pregnant woman.


Prostaglandins and reproduction in the rhesus monkey.


Aggression: instinct or symptom?

Aggression: instinct or symptom?


Effect of prostaglandins on uterine activity in pregnant rhesus monkeys.


Factors affecting the metabolic expenditure of surgical patients.


A new approach for quantitative and semi-quantitative determinations of enzymatic activities with simple laboratory equipment. Detection of  -amylase.


Hydrolysis of a water-insoluble substrate incorporated into solidified medium by enzyme  -amylase contained in normal human urine.


Health care in a longitudinal panel before and after Medicare.


Blood serum antibacterial activity after simultaneous administration of gentamycin and carbenicillin.


Human thyroxine-binding globulin and thyroxine-binding pre-albumin: dissociation rates. 1. A simple method is described for estimating the rate of thyroxine dissociation from binding sites in plasma.2. At tracer concentrations in human plasma thyroxine dissociates at two distinct exponential rates. These are due to the two thyroxine-binding proteins present in human plasma.3. The t((1/2)) for thyroxine dissociation from thyroxine-binding globulin is 8.1 +/- 0.7 (S.E.) min at room temperature and 38.6 +/- 2.1 sec at 37 degrees C.4. The t((1/2)) for thyroxine dissociation from thyroxine-binding pre-albumin is 53 +/- 5.0 sec at room temperature and 7.9 +/- 0.3 sec at 37 degrees C.5. Dissociation of thyroxine from both proteins is a single exponential process, suggesting that each protein has only one type of specific binding site.6. These results indicate that the minute pool of free thyroxine in plasma is turning over about 100 times each second, with about two thirds of this flux being due to release and binding of the hormone by pre-albumin.


The mechanism of thyroxine transfer from plasma to tissue binding sites. 1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine-binding globulin (TBG) and thyroxine-binding pre-albumin (TBPA).2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyroxine dissociation for both TBG and TBPA.3. It is concluded that thyroxine transfer from plasma to tissue-binding sites involves its initial release into the free state and not, as has been suggested, directed exchange.


Jejunal diverticulosis.

Jejunal diverticulosis.


Azidocillin--a new penicillin derivative. 1. Clinical investigation in treatment of scarlet fever.


The concentration of penicillin V in serum and middle ear exudate in acute otitis media in children.


Serum immunoglobulin levels in the course of acute pneumonia.


Sulphonamide-resistant meningococci after sulphonamide prophylaxis among vaval recruits in Norway.


The current status of parenteral hyperalimentation.


Preparation of sterile parenteral hyperalimentation solutions by membrane filtration.


I. The avirulence of the cultivated Y strain of Trypanosoma cruzi.


Immunosuppression, liver injury, and hepatitis in renal, hepatic, and cardiac homograft recipients: with particular reference to the Australia antigen.


The effect of disodium cromoglycate on asthma in children. A double blind study on seven asthmatics during the pollen season.


Minor epilepsies of childhood.

Minor epilepsies of childhood.


Kinetics of calcium metabolism in lactation.


Medical and health aspects of reproduction in the adolescent.


Diagnosis and management of the Rh-immunized patient.


Amniotic fluid analysis.

Amniotic fluid analysis.


The diagnosis of hydrops fetalis.

The diagnosis of hydrops fetalis.


Intrauterine transfusion: indications and results.


The economics of health.

The economics of health.


Treatment of acute lead intoxication--choice of chelating agents and supportive therapeutic measures.


On the variability of tr. coeliacus and its ramifications according to our 107 selective angiographies.


Tissue culture titration of low concentrations of diphtheria antitoxin.


Operative treatment of the severe deformations of the lower extremities in osteochondrodystrophy.


About a new medium for culture of Trichomonas vaginalis.


On the pathogenesis of pterygium.

On the pathogenesis of pterygium.


Comparative toxicity of uncomplexed and complexed chromium: chromic- -glycerophosphate.


Motility of the sigmoid colon and rectum: contribution to the physiopathology of megacolon in Chagas' disease.


Small bowel in typhoid fever.

Small bowel in typhoid fever. Twenty-eight patients with typhoid fever and one patient with paratyphoid fever were subjected to intestinal function tests (faecal fat and D-xylose) and jejunal biopsy soon after recovery from the acute phase of the disease in order to assess the residual functional and morphological status of the small bowel. The results indicate that almost 50% (14/29) initially had defective D-xylose absorption which recovered rapidly. No patient had steatorrhoea. Jejunal biopsies of eight patients out of 22 showed increased chronic cell infiltration; there was, however, no specific lesion. It appears that intestinal injury following salmonellosis results only in mild functional derangement of the bowel which recovers rapidly.


Dacron--silicone prosthesis for the metacarpophalangeal and interphalangeal joints.


Isolation and characterization of peroxisomes from potato tubers.


Segmental distribution of nucleotides in the DNA of bacteriophage lambda.


Conversion of Bacillus subtilis DNA to phage DNA following mitomycin C induction.


Properties of the defective phage of Bacillus subtilis.


Transforming activity in single-stranded DNA from Bacillus subtilis.


Striated visceral muscle of drosophila melanogaster.


Detection and determination of 5,6-dihydrouridine and 4-thiouridine in transfer ribonucleic acid from different sources.


A single amino acid substitution responsible for altered flagellar morphology.


An immunological cross reaction between monkey gonadotrophin preparations and antisera to human gonadotrophins.


The formation and development of the cylindrical bodies in the mammalian epididymis.


An individualized technique for inducing ovulation in the bonnet monkey, Macaca radiata.


Rh iso-immunization following abortion.

Rh iso-immunization following abortion.


Antibodies to spermatozoa. II. Spermagglutination techniques for guinea-pig and human cells.


Clinical and pathologic evaluation of serum immunoreactive human placental lactogen (IR-HPL) in abnormal pregnancy.


Cytotoxic effects of various sera on primary cultures of placentas and ovarian tumors.


Haemophilus influenzae in acute otitis media. Susceptibility of strains from healed cases and from cases with therapeutic failure, treated with penicillin V.


Steroids in primates: 5-androstene-3 , 16 , 17 -triol excretion by a pregnant irus monkey (Macaca fascicularis).


Spheroplast infections of the urinary tract.


The inheritance of the Rh blood groups. I. Frequencies in 1,000 unrelated Caucasian families consisting of 2,000 parents and 2,806 children.


Australia antigen detection by a rapid automated complement fixation method.


Methodology for family studies of genetic factors. Report of a WHO Scientific Group.


Auto-immune hemolytic anemia caused by anti-U.


The ecology, bionomics, and behaviour of Haemaphysalis (Aboimisalis) punctata tick in central Europe.


Bone density changes in a Macaca nemestrina monkey during the biosatellite 3 project.


Management of the severely affected Rh-isoimmunized patient.


Placental transmission and fetal distribution of saccharin.


The development of the idea of fetal transfusion.


A double-blind study of disodium cromoglycate for prophylaxis of bronchial asthma.


Are urban mental health centers worth it? II.


Relationship of dermal and pulmonary sensitivity to extracts of Candida albicans.


Antigens of Histoplasma capsulatum. I. Conditions for assay of teast-phase precipitinogens.


Antigens of Histoplasma capsulatum. II. Separation and characterization of yeast-phase precipitinogens.


Serologic response in squirrel monkeys exposed to nitrogen dioxide and influenza virus.


Disodium cromoglycate in the treatment of seasonal allergic rhinoconjunctivitis in children.


Purification and properties of DNA-dependent RNA polymerase from Bacillus subtilis vegetative cells.


Purification and properties of a catechol-o-methyltransferase of human liver.


[Experience with the intrauterine transfusion in severe rhesus erythroblastosis].


The synthesis of microtubule and other proteins of the oral apparatus in Tetrahymena pyriformis. Several proteins, including microtubule proteins, have been isolated from the oral apparatus of the ciliate Tetrahymena. The synthesis of these proteins has been studied in relation to formation of this organelle system by the cell. Electron microscopy has shown that the isolated oral apparatus consists primarily of basal bodies, pellicular membranes, and a system of subpellicular microtubules and filaments. Cilia were removed during the isolation; therefore none of the proteins studied was from these structures. Evidence was obtained from the study of total oral apparatus protein which indicates that at least some of the proteins involved in formation of this organelle system may be synthesized and stored in the cytoplasm for use over long periods. This pattern of regulation was found for three individual proteins isolated from the oral apparatus fraction after extraction with a phenol-acetic acid solvent. A different pattern of regulation was found for microtubule proteins isolated from the oral apparatus of Tetrahymena. The data suggest that microtubule proteins, at least in logarithmically growing cells, are not stored in a cytoplasmic pool but are synthesized in the same cell cycle in which they are assembled into oral structures.


Phycobilisomes of the thermophilic blue-green alga Synechococcus lividus.


Hybridization properties of DNA sequences directing the synthesis of messenger RNA and heterogeneous nuclear RNA. The relationship of the DNA sequences from which polyribosomal messenger RNA (mRNA) and heterogeneous nuclear RNA (NRNA) of mouse L cells are transcribed was investigated by means of hybridization kinetics and thermal denaturation of the hybrids. Hybridization was performed in formamide solutions at DNA excess. Under these conditions most of the hybridizing mRNA and NRNA react at values of D(o)t (DNA concentration multiplied by time) expected for RNA transcribed from the nonrepeated or rarely repeated fraction of the genome. However, a fraction of both mRNA and NRNA hybridize at values of D(o)t about 10,000 times lower, and therefore must be transcribed from highly redundant DNA sequences. The fraction of NRNA hybridizing to highly repeated sequences is about 1.7 times greater than the corresponding fraction of mRNA. The hybrids formed by the rapidly reacting fractions of both NRNA and mRNA melt over a narrow temperature range with a midpoint about 11 degrees C below that of native L cell DNA. This indicates that these hybrids consist of partially complementary sequences with approximately 11% mismatching of bases. Hybrids formed by the slowly reacting fraction of NRNA melt within 4 degrees -6 degrees C of native DNA, indicating very little, if any, mismatching of bases. Hybrids of the slowly reacting components of mRNA, formed under conditions of sufficiently low RNA input, have a high thermal stability, similar to that observed for hybrids of the slowly reacting NRNA component. However, when higher inputs of mRNA are used, hybrids are formed which have a strikingly lower thermal stability. This observation can be explained by assuming that there is sufficient similarity among the relatively rare DNA sequences coding for mRNA so that under hybridization conditions, in which these DNA sequences are not truly in excess, reversible hybrids exhibiting a considerable amount of mispairing are formed. The fact that a comparable phenomenon has not been observed for NRNA may mean that there is less similarity among the relatively rare DNA sequences coding for NRNA than there is among the rare sequences coding for mRNA.


RNA dependent DNA polymerase in C type particles from normal rat thymus cultures.


Sulphonamide-resistant meningococci in Norwegian naval recruits. An epidemiological study in connection with penicillin prophylaxis.


Evaluation of the in vitro sensitivity of Neisseria catarrhalis to antibiotics with respect to acute otitis media.


Tuberculous meningitis in Nigerians. A study of 194 patients.


Comparative sensitivity of procedures for hepatitis-associated antigen detection.


Hepatitis-associated antigen and antibody in cold ethanol fractionates of human blood.


Radioimmune-complement test for hepatitis-associated antigen.


Studies of the heterogeneity of Streptomyces griseus protease. I. Polyacrylamide gel electrophoresis of commercial pronase-P, derived from Streptomyces griseus K1.


Neisseria gonorrhoeae. Colony variation I.


Cell division in a chain-forming envA mutant of Escherichia coli K12. Fine structure of division sites and effects of EDTA, lysozyme and ampicillin.


Protein A from Staphylococcus aureus XI. Fixation of human complement and of complement from guinea pig and rabbit.


Comparative electrophoretic and serological analyses of Vibrio comma and Aeromonas liquefaciens proteinases.


Antigen analysis on serum from cattle with leucotic tumours.


Distributive pairing in man?

Distributive pairing in man?


The effects of acute crowding on aggressive behavior of Japanese monkeys.


Ventral temporal lobe lesions and visual oddity performance.


Problems of maintenance haemodialysis.

Problems of maintenance haemodialysis.


Immunoglobulin studies in gastrointestinal dysfunction with special reference to IgA deficiency.


Disseminated tuberculosis in elderly patients. A report on three cases diagnosed intra vitam.


Blood lactate and ketone bodies in diabetic ketoacidosis.


Isolation of transmissible enteritis agent of turkeys in avian embryos.


Immobilization and immunodiffusion tests for determination of antibodies against spirochetosis in the yolk of convalescent fowls.


Planning for the development of a community mental health center. II. Planning of services.


A novel form of initiation factors from escherichia coli which binds formyl methionyl tRNA and GTP: "F2-F3 complex".


Classification of avian mycoplasmas by gel-diffusion and growth-inhibition tests.


A new technique of contact lens storage, soaking and cleaning.


Incorporation in vitro of ( 14 C)leucine into the mitochondrial protein of Lucilia cuprina. 1. Basic requirements.


Effects of alteration of biliary pressure on bile composition--a method for study: primate biliary physiology. V.


Clinical and immunological studies in a case of nodular lymphoid hyperplasia of the small bowel.


The etiology of pancreatitis.

The etiology of pancreatitis.


Experimental production of auto-immune liver damage and its correlation with humoral antibodies.


Inhibition of prostatic growth in rabbits with antiovine prolactin serum.


Psychological and neurological correlates of seizure disorders.


Mutation in the structural gene for diphtheria toxin carried by temperate phage  .


The semantic differential as a measure of the patients' image of their therapist.


Radiotherapy of reticulum cell sarcoma of bone.


The megavoltage therapy of urogenital tumors with the 43 MeV betatron. Methods and first results.


Rubella antibodies in infants whose mothers had rubella during the second and third trimesters of pregnancy.


A comparative study of blood concentrations after peroral benzathine (DBED) penicillin V and potassium penicillin V.


Hematologic effects of endotoxin on the macaque monkey.


Skeletal defects induced by cyclophosphamide (endoxan-asta) in chick embryos--preliminary report.


Association of veterinary medical services with reporting of bovine leukemia in selected Minnesota dairy herds.


The assimilation of nucleic acid precursors by intact cells and protoplasts of the blue-green alga anacystis nidulans.


Effects of albumin on the radio-immune assay for determining the anti-Rh o (D) immune globulin.


Immunoglobulins in multiple sclerosis and infections of the nervous system.


Magnesium and calcium ions enhance barotolerance of Streptococci.


Cerebrospinal fluid electroimmunodiffusion. An easy, rapid, sensitive, reliable, and valid method for the simultaneous determination of immunoglobulin-G and albumin.


Effect of chronic methamphetamine intoxication in Rhesus monkeys.


Functional development of the prefrontal cortex in early life and the problem of neuronal plasticity.


A quantitative protamine assay by diffusion in agarose gels containing DNA.


Studies on the attachment and release of 5 s ribosomal RNA from the large ribosomal subunit.


Radiation therapy of skin carcinoma.

Radiation therapy of skin carcinoma.


Serology of coccidioidomycosis.

Serology of coccidioidomycosis.


Preparation and standardization of antigens of Histoplasma capsulatum and Coccidioides immitis.


Development of vaccines for coccidioidomycosis.


Spatial discrimination in the cytoplasm during microtubule morphogenesis.


Identification of primate sexual pheromones and the properties of synthetic attractants.


HL-A antigens on human trophoblast cells.


Mycobacterium abscessus infection in an owl monkey (Aotus trivirgatua).


Prolonged color blindness induced by intense spectral lights in rhesus monkeys. Prolonged exposure of rhesus monkeys to intense blue light produces long-term changes which are consistent with loss of response of those cones that contain a photopigment with peak absorption at 445 nanometers. The 90 percent reduction of spectral sensitivity in the blue region has lasted more than 5 months. Reduced sensitivity to long wavelengths is produced by adaptation to light of 520 nanometers. This reduced sensitivity, which lasts no more than 30 days, is attributed to a temporary loss of response of the cones containing a photopigment with peak absorption at 535 nanometers.


The simultaneous determination in children of glomerular filtration rate and effective renal plasma flow by the single injection celarance technique.


Antibody responses in spider monkeys following single and double infections with group B arboviruses.


Oral D-penicillamine and intramuscular BAL+EDTA in the treatment of lead accumulation.


Rehabilitating the alcoholic.

Rehabilitating the alcoholic.


Feeding jejunostomy.

Feeding jejunostomy.


Deviation of the ureters due to giant bladder diverticula.


Melanosomal acid phosphatase.

Melanosomal acid phosphatase.


Experimental induction of tumors of the large bowel of rats. A review of the experience with 3-2' dimethyl-4-aminobiphenyl.


Colon carcinogens: their metabolism and mode of action.


The assessment and management of the injured hand.


Levels of  -ketoglutarate and glutamate in stimulated pancreatic  -cells.


Retention of  47  calcium administered orally in patients with primary hyperparathyroidism.


Changes in the numbers of neurons and glial cells in the lateral geniculate nucleus of the monkey during retrograde cell degeneration.


An analysis of antibody response to Australia antigen in man.


Paradoxical synergism and antagonism between serum and the antibacterial activity of colistin.


In-vitro and in-vivo studies of resistance to rifampin in meningococci.


Initiation of persistent lymphocytic choriomeningitis infection in adult mice.


Pyelonephritis. XII. Comparison of penicillin, ampicillin, and streptomycin in enterococcal infection in rats.


Hepatitis-associated antigen in chimpanzees.


Purification and characterization o;f a hemolysin produced by Vibrio parahaemolyticus.


Nutrition and ischemic heart disease.

Nutrition and ischemic heart disease.


Mutability at specific euchromatic and heterochromatic loci with alkylating and nitroso compounds in Drosophila melanogaster.


Fine-structure analysis of the chromosome recombinational patterns at the base of the X-chromosome of Drosophila melanogaster.


Increased rate of asporogenous mutations following treatment of Bacillus subtilis spores with ethyl methanesulfonate.


Detection of alpha, kappa and lambda chains in mammalian immunoglobulins using fowl antisera to human IgA.


Mechanical response of skeletal muscle following oral administration of pesticides.


Pharyngeal diverticulum.

Pharyngeal diverticulum.


Relaxant effect of prostaglandin E 1 on the isolated intestine of the toad (Bufo melanostictus).


The management of long term airway problems in infants and children.


Association between serum and secretory immunoglobulins and chronic otitis media in Indian children.


Neuronal cytoplasmic globules in the brain in Morquio's syndrome.


Metachromatic leukodystrophy (MLD). X. Immunological studies of the abnormal sulfatase A.


Biological role of heterologous antibodies against cartilage protein-polysaccharide complex light fraction (PP-L).


Primate hemoglobins: Some sequences and some proposals concerning the character of evolution and mutation.


The effect of calcium deficiency on healing of experimental fractures in the avian tarsus as determined by the fracture repair ratio.


Bone cell response to serum calcium altering drugs.


Glibenclamide, a new sulphonylurea: whither oral hypoglycaemic agents?


Measurement of glomerular filtration rate.


Development of muscle specific proteins in amphibian embryos as studied by means of antisera against total muscle extract and immunofluorescence.


Effects of temperature on selection for scutellar bristles.


Variations in mating propensities in strains of Drosophila melanogaster with different scutellar chaeta numbers.


Effects of  -ecdysone on RNA metabolism of imaginal disks of Drosophila melanogaster.


The synthesis of the immobilization antigens in Paramecium aurelia: in situ localization of immobilization antigen using fluorescein- or ferritin-conjugated antibodies.


Elimination of magnesium ions as an absolute requirement for the native conformation of tryptophan transfer ribonucleic acid.


Renoprival erythropoietin responsiveness in subhuman primates.


Effect of prostaglandin E 1  on platelet aggregation in vitro and in hemorrhagic shock.


The effect of prolactin on organ weights and zinc-65 uptake in male baboons.


Deoxyribonucleic acid polymerase activity associated with a plasma particulate fraction from patients with chronic lymphocytic leukemia. Plasma from two cases of chronic lymphocytic leukemia have been examined for deoxyribonucleic acid (DNA) polymerase activity. In both cases, detectable enzyme activity was present. In the plasma from a patient known to have chronic lymphocytic leukemia for 10 years, the enzyme activity was sufficiently high to study product formation, buoyant density of the enzyme activity, deoxyribonucleoside triphosphate requirements, and kinetics of DNA synthesis. These studies are presented in this report.


The G and H Rhesus monkey blood group systems.


Australia antigen and viral hepatitis: a brief review and a preliminary Australian report.


Epistasis in eye colors of Drosophila melanogaster.


Clinical value of immunoelectrophoresis in multiple myeloma.


Morphologic alterations in the transplanted primate lung.


A new model for producing experimental fecal peritonitis.


Safeguards in the repair of pharyngoesophageal diverticulum.


The effects of X-irradiation on the cerebral cortex of the monkey.


Characteristics of pontine pathways for conjugate horizontal gaze.


Application of rabbit cortex antisera on mirror foci in rabbits.


Observations on the discrepancy between the clinical and the laboratory effects of anti-petit mal drugs.


Bilateral symmetrical epileptogenic foci in monkey cerebral cortex: regional variations in capacity for synchronous discharge and mechanisms of interaction.


Experimental myoclonus of thalamic origin.


Cerebellar dentatectomy in primates and humans.


Oxygen tension dynamics in the cerebrospinal fluid.


Experimental petit mal.

Experimental petit mal.


Cerebral metabolism and blood flow during induced epilepsy.


Double-stranded viral RNA.

Double-stranded viral RNA.


Effects of anions on sodium transport in toad urinary bladder.


Uric acid metabolism in Cebus monkeys.

Uric acid metabolism in Cebus monkeys.


Functional evaluation of esophageal reconstructions.


Radiometric method for detection of bacteremia. A study was performed with simulated blood cultures to evaluate the production of (14)CO(2) as an index of bacterial growth. With a range of inoculum sizes from 4 to 4,250 colony-forming units, it was not possible to detect (14)CO(2) within 6 hr after inoculation in 59 separate experiments. In a limited trial with patients' blood cultures, the radiometric method failed to provide any earlier evidence of bacteremia than did routine broth cultures.


Growth and cultivation of the unusual generalized transducing Bacillus bacteriophage SP-15. Additional properties of SP-15, a generalized transducing bacteriophage notable for the ability to transfer an unusually large fragment of deoxyribonucleic acid (DNA) to Bacillus subtilis and B. licheniformis, are presented together with improved methods that enhance its utility. Simple means have been found to provide the rigid control over moisture that is necessary for the assay of plaque-forming units (PFU). Reproducible procedures for propagating transducing phage, which depend upon an appropriate mixing of PFU with uninfected bacteria, have replaced less reliable methods that utilized infected spores. Transduction of B. subtilis W-23 increased linearly when MgSO(4) in recipient cell-SP-15 mixtures was increased from 0.005 to 0.03 m. Methods have been developed that protect SP-15 from the damaging effects of CsCl and of osmotic shock subsequent to dilution. Evidence that the PFU and transducing particles of lysates decay at the same slow rate during extended storage suggests that the decay is a result of damage to protein rather than to DNA. One-step growth experiments, in which SP-15 was propagated on B. subtilis W-23-S(r)/1 mg, indicated a latent period of 100 min, a rise period of 60 min, and a burst size of 25 to 34 PFU per infected cell. These findings suggest explanations for some of the technical difficulties SP-15 has presented.


Role of carbon and nitrogen sources in bacterial growth and sporulation. A simple growth medium is reported, in which Bacillus megaterium forms heat-stable spores, heat-labile spores, or only vegetative cells by changing the carbon and nitrogen source. Studies carried out in such media could be very useful in elucidating biochemical events which lead to bacterial sporulation.


Effect of the method of agitation on the accumulation of protective antigen in cultures of Bacillus anthracis. Accumulation of protective antigen was essentially independent of culture volume, provided the organisms were kept in suspension by stirring. Agitation by orbited shaking was unsatisfactory.


Comparison of media for isolation of salmonellae and shigellae from fecal specimens. Five transport media, eight plating media, and three enrichment broth media for the isolation of salmonellae and shigellae were evaluated. Eight laboratories in widely separated regions of the United States participated in this evaluation by submitting 490 fecal specimens in the transport media provided. The results suggest that the newer transport media may not offer any advantage over the use of buffered glycerol-saline in the isolation of these enteric pathogens. Shigellae were best isolated by direct inoculation, whereas salmonellae were isolated in greater numbers after tetrathionate (without Brilliant Green) enrichment with subsequent culturing on the plating medium. The use of a variety of plating media is recommended for the recovery of a larger number of these enteric pathogens.


Biochemical responses to provocative chelation by edetate disodium calcium.


Antigenic variation in strains of avian infectious bronchitis virus.


Antigens of Pasteurella tularensis: preparative procedures. Ether-water (EW) extraction of Pasteurella tularensis produced better antigens than five other chemical procedures. EW extracts produced from stationary-phase, liquid-grown, saline suspensions of strain SCHU S4 cells regularly induced agglutinin and precipitin formation in rabbits. Mice, guinea pigs, and monkeys also responded to EW extracts but with lower antibody levels. The use of strains of lower virulence, acetone-dried cells, organisms grown on a solid medium, and abbreviated extraction conditions all resulted in extracts with a diminished antigenicity, but logarithmic-phase and stationary-phase cells yielded equivalent EW extracts. The use of adjuvant, hyperimmunization, and large doses of antigen increased the precipitin responses of rabbits without appreciably altering the agglutinin response. By the appropriate combination of centrifugal fractionation of EW extracts, use of adjuvant, and vaccination schedule, rabbit antisera with either predominantly agglutinating or precipitating activities were obtained.


Inactivation of thirty viruses by gamma radiation. Decimal reduction values (D value) for 30 viruses were determined. The weighted D values of the viruses suspended in Eagle's minimum essential medium ranged from 0.39 to 0.53 Mrads. It was necessary to increase the radiation dose by a factor of >3 to inactivate virus suspended in Eagle's minimum essential medium as compared to the same virus suspended in distilled water. The destruction rate curves were of a first-order reaction.


Heterogeneous viral population chromatography of ECHO virus type 11 on distinction of several fractions by calcium phosphate and kinetic neutralization test.


An evaluation of bovine albumin and sodium glutamate in the lyophilization of Neisseria gonorrhoeae.


An evolutionary approach to research on the life cycle.


Relationships between relative binding affinity and electrophoretic behavior of rabbit antibodies to streptococcal carbohydrates. After repeated intravenous injections with Group C streptococcal vaccine, most rabbit antisera were shown to contain one or more IgG antibody components, as revealed by microzone electrophoresis. A procedure for the fractionation of multiple IgG antibody components from such streptococcal antisera is described. Separation is achieved on the basis of differences in relative binding affinities of the antibody components to immunoabsorbent columns. The evidence suggests that the electrophoretic mobility, and thus the net charge of an antibody, bears a reciprocal relationship to its binding affinity for the streptococcal Group C antigens. Furthermore, the relative binding affinity affords another means to assess the functional homogeneity of streptococcal antibodies. A possible relationship between light chain variable-region subclasses and binding affinities of streptococcal antibodies is discussed.


Spontaneous and tryptic degradation of virus particles and structural components of adenoviruses.


[Syphilis serodiagnosis, with special reference to FTA-ABS and TPHA].


The effect of K+-sparing diuretics on ion transport across the excised toad bladder.


Placental transfer of diazepam- 14 C in mice, hamsters and monkeys.


Segregation following interchange induced by irradiating mature oocytes of Drosophila melanogaster.


Induction of recessive lethals in Drosophila melanogaster by aflatoxin B 1 .


Inactivation of genetic markers in transforming DNA of Bacillus subtilis by an enzyme which preferentially splits the guanine-guanine bonds in DNA.


Genetic effects of LSD in Drosophila melangoaster sperm.


Titration of oral nicotine intake with smoking behaviour in monkeys.


Nonencapsidated infectious DNA of adeno-satellite virus in cells coinfected with herpesvirus. Adeno-associated satellite viruses produce antigen detectable by immunofluorescence but not infectious virus in tissue culture cells coinfected with herpes simplex virus. Analysis of DNA extracts from these infected cells shows that large amounts of infectious satellite virus DNA are produced but not encapsidated in the system. This result indicates that satellite virus may be defective at the maturation step.


Analysis of cutaneous warm and cold fibres in primates.


Premature cessation of neurogenesis and gliogenesis in rats showing runt syndrome.


Effects of acetazolamide on cerebral ischemia and infarction after experimental occlusion of middle cerebral artery.


Isolation and characterization of some humic acid decomposing bacteria and fungi from soil.


Pentose-phosphate pathway of erythrocytes in metabolic diseases.


Adenosine-5'-monophosphate aminohydrolase of human placenta.


Red-cell catalase and the production of methaemoglobin, Heinz bodies and changes in osmotic fragility due to drugs.


Erythropoietic cell proliferation in different clinical states of  -thalassaemia.


The incidence of  -thalassemia and abnormal hemoglobins in Turkey.


Stable suspension of erythrocytes suitable for calibration of the electronic counters.


Kinetics of erythroid bone marow cells of normal and porphyric calves in vitro.


Megaloblastic anemia due to folic acid deficiency in a young woman on oral contraceptives.


Parenteral nutrition for the surgical patient. A review of indications and current practice.


"Triiodothyronine (T 3 ) toxicosis". Its role in Graves' disease.


Pseudomonas septicemia. Illustrated evolution of its skin lesion.


Pet animal infestations and human skin lesions.


Skin flora of infants with napkin rash.

Skin flora of infants with napkin rash.


Effects of medullary pyramidotomy in the monkey. I. Clinical and electromyographic abnormalities.


On the intracerebral origin of homovanillic acid of the cerebrospinal fluid of experimental animals.


IgD plasma cell neoplasia: clinical manifestations and characteristic features. Three patients, one with plasma cell leukemia and clinically asymptomatic hypernephroma and meningioma, and two others with multiple myeloma, had M-components of IgD/lambda type. In the first case, IgD globulin was found in the serum, ascitic and pleural fluids. Including our patients, 50 cases of IgD myeloma have been reported in the literature. A review of this group showed some significant differences from the other classes of multiple myeloma. IgD myeloma seems to involve a larger proportion of younger people, 66% being less than 59 years of age. The involvement of internal organs and renal damage were more frequent in IgD myeloma than in other classes. Serum total protein was frequently not increased, the relative concentration of M-component was often low and in 12% there was no spike in electrophoresis. The diagnosis therefore was sometimes difficult. In a quarter of the cases Bence Jones proteinemia was found and in 15% there were multiple spikes, both these manifestations being rare in IgG or IgA classes of myeloma. In 89%, IgD globulin had lambda type light chain, clearly contrasting with the figure of approximately 30% in other classes. Bence Jones protein was found in the urine in 91%. The survival time seemed to be shorter than in other myelomas.


Cellular dynamics of pattern duplication in imaginal discs of drosophila melanogaster.


Incorporation of amino sugars into walls during heterocyst differentiation.


Aldehyde oxidase in Drosophila melanogaster: a system for genetic studies on developmental regulation.


Pulmonary acariasis in rhesus monkeys: electron microscopy study.


The effect of insulin deficiency, hypothyroidism, and hypertension on atherosclerosis in the squirrel monkey.


Topographical relationships between the anatomy and physiology of the rabbit visual system.


Use of the coulter counter to count cells of Streptococcus faecalis.


Preliminary observations on the effects of a synthetic thyrotropin releasing factor (Ro 8-6270-2) in normal and endocrinopathic subjects.


The effects of bile salts media and the age of inocula in quantitative studies of populations of Erwinia carotovora var. carotovora and E. carotovora var. atroseptica.


Thermal and metabolic responses in the Japanese monkey at temperatures of 5-38 degrees C.


Automated method for continuous determinations of protein and fluorescein in cerebrospinal fluid.


Disodium cromoglycate in the treatment of bronchial asthma: a controlled clinical trial.


Large-scale isolation and fractionation of organs of Drosophila melanogaster larvae. Methods for the mass isolation of diverse organs from small animals are described. They involve novel devices: a mechanical dissecting system, a centrifugal agitator for the separation of fibrillar from globular particles, and a settling chamber for the fractionation at unit gravity of particles with sedimentation velocities above the useful range for centrifugation. The application of these methods to the isolation of polytene and nonpolytene nuclei from Drosophila melanogaster larvae is described.