The relation between infecting ndosage and median survival in tuberculous guinea pigs.


The induction of a dehydrogenase activity for branched chain amino acids in Bacillus subtilis.


Pseudomonas chest infection.

Pseudomonas chest infection.


A comparative study of adrenal steroid biosynthesis in two species of monkeys.


The conformation of an atypical IgG myeloma protein and its papain fragments.


An immunological and chromatographic comparison of human intrinsic factor and the acid-stable gastric esterase VI A.


Stimulation of common endothelium during autoimmune induction in the mouse.


Interaction between ABO and rhesus blood groups, the site of origin of gastric cancers, and the age and sex of the patient. ABO and Rhesus blood group data have been examined for 1,680 patients treated for gastric cancer in four London hospitals. The risk of developing gastric cancer was estimated to be 16% higher for group A subjects than for group O subjects, in close agreement with many previous reports throughout the world. More detailed analysis failed to support the suggestion that there was any special correlation between either ABO or Rhesus blood groups and the site of origin of the tumour within the stomach or the sex or age of the patient. Male predominance among the patients was noted to be greater at ages 40-69 years than at other ages and greater for tumours of the upper two thirds of the stomach than for tumours that arose distally.


Elevation of IgA and other changes in sera with antibodies to Chlamydiae.


The serum concentration of the third component of complement beta-1C-beta-1A in liver disease. Serum C(3) (beta(1C)/beta(1A)) has been measured in normal individuals and the range found is in agreement with findings of other authors (85-370 mg/100 ml). In 18 patients with acute hepatitis and massive necrosis serum C(3) was consistently reduced to below 50% of normal. In other patients with acute hepatitis the serum C(3) concentration was normal. In the majority of the 150 patients with chronic liver disease serum C(3) concentration was normal. However, 10 patients (six with active chronic hepatitis, four with cryptogenic cirrhosis) had hypocomplementaemia. The reason for the depression is not clear but could reflect either decreased synthesis or increased consumption, or a combination of the two.


Pulmonary retention of zirconium oxide ( 95 Nb) in man and beagle dogs.


Human antibodies against bovine immunoglobulin M in IgA deficient sera.


Punishment for errors and visual-discrimination learning by monkeys with inferotemporal cortex lesions.


Role of adipose tissue in diabetic ketosis.


The pathogenesis of junctional nodules in schistosomiasis.


Perinatal listeriosis.

Perinatal listeriosis.


Disc electrophoretic separation of proteins in neuronal, glial and subcellular fractions from cerebral cortex.


Cross-linking of elastin in human atherosclerotic aortas. I. A preliminary study.


Renal fate of staphylococcal enterotoxin B.


Five-year follow-up of primates exposed to 55 MeV protons.


The diagnosis and treatment of acute meningitis, excluding tuberculosis, in infancy and childhood.


Nucleic acid metabolism in normal and leukemic cells. Introduction.


Regulation of deoxyribonucleotide synthesis by ribonucleotide reductase in leukemic leukocytes.


Repeated sequences in human leukemic DNA.


Synthesis and metabolism of DNA and DNA precursors by human normal and leukemic leukocytes. A summary of recent information.


Metabolism of RNA in normal and leukemic cells.


RNA metabolism of circulating lymphocytes studied in man after autotransfusion and in vitro 3 H-cytidine labeling.


Autoradiographic studies on the kinetics of nuclear-cytoplasmic transfer of RNA in blast cells of acute leukaemia.


Impaired  of ribosomal precursor RNA in blast cells of acute leukemia.


Rifampin: characteristics and role in the chemotherapy of tuberculosis.


Encephalocele, polycystic kidneys, and polydactyly as an autosomal recessive trait simulating certain other disorders: the Meckel syndrome.


Inhibition of hepatic drug-metabolizing enzymes by pyridoxine-5-disulfide 2HCl-2H 2 O(pyrithioxine).


Complete purification and some properties of phospholipase C from Bacillus cereus.


Cysteine and S-sulphocysteine biosynthesis in bacteria.


Conditional cardiac and suppression responses after lesions in the dorsomedial thalamus of monkeys.


Behavioral deficits in monkeys after selective lesions within the middle third of sulcus principalis.


An epidemiological analysis of cancer vaccines.


Further analysis of visual discrimination deficits following foveal prestriate and inferotemporal lesions in rhesus monkeys.


Primate cutaneous thermal nociceptors.

Primate cutaneous thermal nociceptors.


Cell-mediated immunity and antibody responses in the respiratory tract after local and systemic immunization. The cell-mediated immune response on the secretory surface of the lower respiratory tract was investigated and compared to the systemic cell-mediated immune response and to the secretory and systemic antibody responses. Guinea pigs were immunized either parenterally or locally with dinitrophenylated human IgG. The effect of rendering animals tolerant on the local cell-mediated response and on the local antibody response was also studied. The antibody response in the bronchial washing fluids was predominantly of the IgA class. In the animals rendered tolerant by administering large doses of the antigen intravenously, the secretory antibody response was significantly reduced to about 40% of the levels in the animals which were not tolerant. Cellular immunity was assayed using the inhibition of macrophage migration. In animals which were immunized subcutaneously, splenic lymphocytes strongly inhibited the migration of normal guinea pig macrophages; however cells obtained from bronchial washings from the same animals exhibited little or no inhibition of macrophage migration in the presence of antigen. In the animals which were immunized by nose drops, splenic lymphocytes showed virtually no inhibition of macrophage migration; however, bronchial washing lymphocytes strongly inhibited the migration of normal macrophages. Thus, nose drop immunization gave rise to a significantly greater local cellular immune response than did parenteral immunization. In those animals which were immunized by nose drops after a tolerizing dose of antigen, there was virtually no inhibition of macrophage migration by either the cells from the spleens or bronchial washings. Studies were done which demonstrated that a substance similar to macrophage-inhibition factor was liberated by the bronchial washing cells on incubation with the antigen. Studies were also done which indicated that secretory antibody played no role in the inhibition of macrophage migration when bronchial washing lymphocytes were used. Lymphocytes were purified from bronchial washings and were found to inhibit normal macrophage migration in the presence of antigen to the same extent that the mixed population of lymphocytes and pulmonary macrophages did. Thus this study supports the concept that local cellular immunity can be initiated independently of systemic cellular immunity.


Diverticulosis and muscular hypertrophy of the small intestine of horses, pigs and sheep.


Protocol for the dosimetry of x- and gamma-ray beams with maxi um energies between 0-6 and 50 MeV. Scientific Committee on Radiation Dosimetry (SCRAD) of the American Association of Physicists in Medicine.


The recoil proton dose across a bone-tissue interface due to fast neutrons.


An ionization chamber for the dosimetry of 14 MeV neutron beams.


The use of commercially available ionization chambers for absorbed dose calibrations of high energy x-rays and electron beams.


An instrument for measuring small differences in dose rate at points in a radiation beam.


Subunit structure of the phycobiliproteins of blue-green algae. The phycobiliproteins of the blue-green algae Synechococcus sp. and Aphanocapsu sp. were characterized with respect to homogeneity, isoelectric point, and subunit composition. Each of the biliproteins consisted of two different noncovalently associated subunits, with molecular weights of about 20,000 and 16,000 for phycocyanin, 17,500 and 15,500 for allophycocyanin, and 22,000 and 20,000 for phycoerythrin. Covalently bound chromophore was associated with each subunit.


Quantitative two-dimensional ultrastructural distribution of Rh  o (D) antigenic sites on human erythrocyte membranes. A method is described for determining the two-dimensional distribution of specific antigens on cell surfaces, and is applied to the D antigen of the Rh antigenic system. Rh-positive human erythrocytes are allowed to react with purified (125)I-labeled human anti-Rh(o)(D) gamma-globulin antibodies, and the sensitized cells are then lysed at an air-water interface. The residual cell membranes are spread flat by surface forces, and are picked up on a carbon-strengthened collodion-coated electron microscope grid. The membranes are then stained with ferritin-conjugated goat antibodies directed against human gamma-globulins. Only Rh-positive cells sensitized with anti-Rh(o)(D) antibodies bind the ferritin-conjugated antihuman gamma-globulins. The ferritin particles are found in small clusters on the membrane surface, and the number of such clusters per unit area agrees with the number of (125)I-labeled anti-Rh(o)(D) antibodies bound per unit area. The Rh(o)(D) antigenic sites appear to be molecularly dispersed on the membrane surface, but in a random two dimensional array.


Interchain and intrachain disulfide bridges of a human immunoglobulin M: detection of a unique fragment. Studies of the amino acid sequences around half-cystine residues in an immunoglobulin M have revealed an unexpectedly high number. At least 14 different sequences were found in the mu chain (V(HIII) subclass). Four of these were involved in interchain disulfide bridges and at least 10 in intrachain bridges. Five came from the kappa chain (kappa(III) subclass, Inv b). Several others, although having a high degree of homology, were not identical with those of either the mu or kappa chains. These results support the concept of an additional fragment in gammaM molecules, although its function and localization remain to be determined.


Immunological evidence for an inactive precursor of collagen proline hydroxylase in cultured fibroblasts. A specific antibody to rat collagen proline hydroxylase has been used to measure the amount of "enzyme" protein in cultured mouse fibroblasts (L-929 cells) during normal growth, and under other conditions that cause an increase in enzyme activity. Collagen proline hydroxylase activity per mg of cell protein increased 24-fold as the cells progressed through the logarithmic to the stationary phase of growth, while the cellular concentration of immunologically reactive protein changed only slightly. Similar results were obtained with cells in early log phase in which enzyme activity was stimulated severalfold by cell concentration or lactate treatment without a corresponding change in cellular antigen. It has also been shown that the enzymatically inactive antigen in these fibroblasts competes effectively for antibody-binding sites with partially purified enzyme. It is concluded that early-log-phase fibroblasts contain an inactive form of collagen proline hydroxylase which may be a precursor of the functional enzyme.


Serological and structural properties of Mason-Pfizer monkey virus isolated from the mammary tumor of a Rhesus monkey. We describe here serological and structural properties of a virus, Mason-Pfizer Monkey Virus (M-PMV), isolated from a simian mammary tumor. This virus is morphologically similar to the known oncogenic RNA viruses (oncornaviruses). It has a 60-70S RNA, and its replication is inhibited by actinomycin. Antisera prepared against the virus isolated by density-gradient centrifugation identify at least two viral structural antigens. Immunodiffusion studies show that this virus is serologically unrelated to three types of simian foamy viruses, visna virus, and the known oncornaviruses. Immunofluorescence reveals that the structural proteins of the virus are synthesized cytoplasmically. Although M-PMV productively infects human cells in vitro, serological analysis does not show the presence of M-PMV antigens in human neoplasia.


Serum immunoglobulin D and malaria antibodies in South Vietnamese residents.


A possible technique for testing gametocidal drugs.


A variable-deadspace device for use with the Engström respirator.


Lead poisoning.

Lead poisoning.


Cellular responses determining the effectiveness of fast neutrons relative to x-rays for effects on experimental tumours.


Counterelectrophoresis for detection of hepatitis--associated antigen: methodology and comparison with gel diffusion and complement fixation.


The binding of Bacillus subtilis alkaline proteinases to alpha-2-macroglobulin.


Syntheses of pyroglutamylhistidylprolinamide and unusual mass fragmentation.


Hemifacial microsomia--oculo-auriculo-vertebral dysplasia. A patient with overlapping features.


Nitroglycerin tablets. Loss of potency.

Nitroglycerin tablets. Loss of potency.


The National Library of Medicine.

The National Library of Medicine.


Pathophysiology and differential diagnosis of cardiac pain.


Cerebrospinal fluid production by the choroid plexus and brain. The production of cerebrospinal fluid and the transport of (24)Na from the blood to the cerebrospinal fluid were studied simultaneously in normal and choroid plexectomized rhesus monkeys. Choroid plexectomy reduced the production of cerebrospinal fluid by an average of 33 to 40 percent and the rate of appearance of (24)Na in the cerebrospinal fluid and its final concentration were proportionately reduced. In both normal and plexectomized animals, (24)Na levels were found to be markedly greater in the gray matter surrounding the ventricles and in the gray matter bordering the subarachnoid space. That sodium exchanges in these two general areas of the brain may be linked to the formation of the cerebrospinal fluid is discussed here.


Recovery of function after serial ablation of prefrontal cortex in the rhesus monkey. Rhesus monkeys with one-stage or serial ablation of sulcus principalis (prefrontal association cortex) were compared on three spatial tasks. On all tests, the serial monkeys made fewer errors than did the monkeys with onestage lesions. These results indicate that partial recovery of function can occur after extensive destruction of association cortex in the mature primate brain if the damage is distributed over a number of operations.


Evaluation of food additives. Specifications for the identity and purity of food additives and their toxocological evaluation: some extraction solvents and certain other substances; and a review of the technological efficacy of some antimicrobial agents. Fourteenth report of the joint FAO-WHO Expert Committee on Food Additives. Geneva, 24 June-2 July 1970.


Studies on dog saliva. II. Observations on arylaminopeptidase activity.


The effect of cordycepin on nuclear RNA synthesis in nerve and glial cells.


Tissue reactions in the temporomandibular joint resulting from anterior displacement of the mandible in the monkey.


Pulpal response following anterior maxillary osteotomy.


Effect of methyltestosterone on the apolipoprotein and lipid composition of canine serum lipoproteins.


Studies on fraction-I protein. 3. Comparison of the primary structure of the large and small subunits obtained from five species of Nicotiana.


Protective cross-immunity between Trypanosoma cruzi and T. lewisi.


Some immunochemical properties of beef liver esterase.


Immunoglobulin IgA in bovine mammary secretions and serum of the neonatal calf.


Occurrence, isolation and interchain bridges of natural 7-S immunoglobulin M in human serum.


Comparative studies of alpha-crystallin during development of the bovine lens.


Solubilization and chemical and immunochemical characterization of sparingly soluble canine gastric mucin.


The partial structure of human plasma prealbumin and retinol-binding protein.


Rifampicin with ethambutol for drug-resistant tuberculosis.


Transformation with sonicated DNA.

Transformation with sonicated DNA.


Toxicity of nitrosamines: their possible human health hazards.


Naturally-occurring autoantibodies to mouse thymocytes.


Epidemiological and experimental aspects of lead and mercury contamination of food.


Treatment with chlorpropamide-phenformin combination in adult, obese, ketosis-resistant diabetics.


"Comparison of antimuscarinic actions of anticholinergic agents in normal human volunteers".


Prefrontal cortical unit activity and delayed alternation performance in monkeys.


Activity of pallidal neurons during movement.


Baboon flexor and extensor fusimotor neurons and their modulation by motor cortex.


Neonatal hypoglycemia: a discussion.

Neonatal hypoglycemia: a discussion.


Blood-pool imaging of the placenta with short-lived radioisotopes.  113m Indium-gelatin Vs  131 RISA and  99m technetium-albumin.


Acetone in uncontrolled diabetes.

Acetone in uncontrolled diabetes.


Prophylactic antibiotics in cesarean section.


The prevention of hepatitis in haemodialysis units.


Ammonia production in germ-free Eck fistula dogs.


Prolonged respiratory support in newborn infants with a membrane oxygenator.


Immunodiffusion tests with Rh antigens and antibodies.


Another example of an albumin auto-agglutinin.


Morphological studies on Herpesvirus saimiri in subhuman and human cell cultures.


Regan isoenzyme: a carcinoplacental antigen.


Light-induced shifts in pigment absorption in green, red and blue-green algae.


A transmissible feline fibrosarcoma of viral origin.


Urinary and biliary excretion of the 2,4-diaminoquinazoline antifolate, methasquin, in rats and dogs.


Activity of alkaline phosphatase and carbonic anhydrase in male and female zinc-deficient rats.


Enzymology of experimental liver disease in marmoset monkeys. I. Patterns of enzyme activity in liver, other organs and serum of marmosets, compared to man and other mammals.


The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. The effect of 2-oxobutyrate upon the enzyme activity.


Isolation of the human retinol binding protein by affinity chromatography.


An electron cytochemical study of glucose-6-phosphate dehydrogenase activity in erythrocytes of malaria-infected mice, monkeys and chickens.


Genetics of the Meckel syndrome (dysencephalia splanchnocystica).


The selective inactivation of an ESF-generating factor (EGF) in the presence of erythropoietin (ESF).


Saccharin metabolism in Macaca mulatta.

Saccharin metabolism in Macaca mulatta.


Effect of the interferon stimulator polyinosinic-polycytidylic acid on experimental Trypanosoma cruzi infection.


Effects of norepinephrine infusions on mesenteric arterial blood flow and its tissue distribution.


The exocellular lipase from Rhizopus arrhizus.


Serological specificity of type E botulinal toxin.


The anti-complement fluorescent antibody technique for the identification of mycobacteria.


Epidemiology of trypanosomiasis in man.

Epidemiology of trypanosomiasis in man.


The blood-brain barrier to protein tracers in focal cerebral ischemia and infarction caused by occlusion of the middle cerebral artery.


Direct observations of the canine sphincter of Oddi.


Ischemia potentiating cryosurgery of primate liver.


Spontaneous rupture of the esophagus: Boerhaave's syndrome.


Thymus involution in tumour-bearing hosts: mechanisms and possible significance.


Plasma renin activity in chronic plumbism. Effect of treatment.


Australia antigen and viral hepatitis in drug abusers.


Techniques for measring histamine formation in mice. 1. Formation of (14)C-histamine from (14)C-L-histidine was studied in mice using various inhibitors of histamine catabolism; these included aminoguanidine, pargyline and methylhistamine, inhibitors of diamine oxidase, monoamine oxidase, and the histamine-methylating enzyme, respectively.2. Four general approaches were used: inhibiting diamine oxidase and the histamine-methylating enzyme and measuring (14)C-histamine in tissues or urine, or inhibiting diamine oxidase and monoamine oxidase and measuring (14)C-methylhistamine in tissues or urine. In some tests mice with normal concentrations of histidine decarboxylase were used; in others the enzyme was activated by pretreating mice with Freund's adjuvant.3. Methylhistamine pretreatment increased (14)C-histamine in several tissues of mice but aminoguanidine had no significant effect; it was concluded that endogenously formed histamine is inactivated almost entirely by methylation.4. There was no evidence of parallelism between the ability of tissues to form histamine and to inactivate endogenous histamine.5. Effects of Freund's adjuvant on tissue concentrations of (14)C-histamine were tested in mice with or without inhibitors of histamine catabolism. Results were essentially parallel in both cases but higher in the former.6. The method of choice is measurement of (14)C-histamine in tissues of mice given aminoguanidine and methylhistamine, followed by (14)C-L-histidine.7. Other approaches listed above may be useful but require improvement, for example, a more specific assay for (14)C-methylhistamine and a stronger, longer-lasting inhibitor of histamine-methylation.


Isolation of thyroidal acid protease and immunological analysis of its antibody.


Availability in the dog of radionuclides in nuclear debris from the Plowshare Excavation Cabriolet.


Disodium cromoglycate and inhibition of passive cutaneous anaphylaxis.


The cardiac auto-immune system.

The cardiac auto-immune system.


Double blind single crossover clinical evaluation of disodium cromoglicate in bronchial asthma.


Biochemical studies of lymphocyte cytotoxicity.


Chemotherapy in nephrolithiasis.

Chemotherapy in nephrolithiasis.


Zeroing of microelectrodes to targets within the brain.


A hydrophilic polymer-coated antimicrobial urethral catheter.


A policy for biomedical research. Report of an Ad Hoc Committee of the Council of Academic Societies of the Association of American Medical Colleges.


The effect of increased intracranial pressure on cerebrovascular hemodynamics.


Intracranial midline anterior fossae ossifying fibroma invading orbits, paranasal sinuses, and right maxillary antrum. Case report.


Hypopharyngotomy.

Hypopharyngotomy.


A contribution to the study of the haematozoon parasites of bats. A new mammalian haemoproteid, Polychromophilus deanei n. sp.


Pulsatile echoencephalography: correlations with K-complexes and epileptic discharges.


Physiological studies on the development of obstructive hydrocephalus in the monkey.


Central neurogenic control of cerebral blood flow.


Chronic Listeria monocytogenes meningitis and normotensive hydrocephalus. Case report and review.


Chemical induction of tubal blockade in the monkey. The ability of the retrograde transtubal instillation of toxic agents to produce isthmic tubal occlusion was studied at laparotomy in 8 healthy, parous pigtail monkeys.  The agents used were silver nitrate in 2 hydrophilic concentrations, hydrophilic ointment with 50% zinc chloride, and methyl alpha-cyanoacrylate with about 5% zinc chloride.  An acute and chronic inflammatory response was observed to extend through about 33% of the isthmic tubal wall in all animals.  Tubes treated with cyanoacrylate differed from the others in that a giant-cell reaction occurred around the agglomerated polymer.  A gradual invasion of the tubal lumen by plump, active fibroblasts was evident at 5-7 weeks.  Tubes instilled with silver nitrate showed the greatest rate of fibrosis.  By 7 weeks, all treated tubes showed hematological evidence of closure.  In other studies, repeated tubal injury by electrocoagulation or instillation of phenol, silastic, or quinacrine resulted in tubal occlusion.  Experiments with tubal-occluding agents hold the prospect of developing occlusive agents that can be administered transcervically in humans.


Electroencephalographic activation with intravenous methohexital in psychomotor epilepsy.


Intrauterine fetal transfusion in the management of Rh disease.


Nonimmunologic hydrops fetalis and congenital abnormalities.


Unilateral function and the temporomandibular joint in rhesus monkeys.


Functional anatomy of the shoulder complex. A review.


The uptake of 35S sulfadiazine by sulfonamide-sensitive and resistant Neisseria meningitidis with reference to its mode of action.


Monoexponential extrapolation of tracer clearance curves in kinetic analysis.


Occurrence of 22Na in medium-sized animals.


Results of the whole-body counting of patients with known amount of injected thorotrast.


The exponential decrease of  137 Cs in man from mid-1965 through mid-1968 and its significance.


Ultrasonic threshold dosages for the mammalian central nervous system.


A system for continuous mointoring of potential dose rate to the gastrointestinal tract from drinking water.


Glucosylation of lipopolysaccharide in Salmonella: biosynthesis of O antigen factor 12 2 . I. Over-all reaction.


The effect of tyrosyl modification on the activity of  -lactalbumin in the lactose synthetase reaction.


Immunochemical properties of ovine interstitial cell-stimulating hormone subunits.


The glycogen phosphorylase of Tetrahymena pyriformis. II. Inhibition and inactivation by EDTA and ATP and other kinetic properties.


Urinary excretion of kidney antigens in rats with experimental glomerulonephritis and pyelonephritis.


The response of the hypothalamus to high doses of monosodium glutamate in mice and monkeys. Cytochemistry and ultrastructural study of lysosomal changes.


Separation and characterization of two fibrinolytic inhibitors from human placenta.


A new laboratory for whole-body counting.


Monitoring for internal contamination of nuclear energy personnel.


137 Cs levels of different population groups in Sweden.


Levels of  137 Cs in agricultural products in Norway and in the population 1964-1965.


Control of a lysine-biosynthetic step by two unlinked genes of Saccharomyces.


Elastolytic activities of Clostridium histolyticum.


Does the elimination rate of cesium in humans change with the seasons?


Evaluation of accidental personnel exposure to plutonium-238: whole body counting and bioassay results.


"Total" and "exchangeable" sodium studies in swine and sheep using activation analysis and isotopic dilution.


Studies on mitomycins. V. Synthesis of indolequinone and their activities.


3',4'-dideoxy-kanamycin B active against kanamycin-resistant Escherichia coli and Pseudomonas aeruginosa.


The Australia antigen in viral hepatitis: a changing concept.


The oral microbiota of man from birth to senility.


Unexpected death in young epileptics.

Unexpected death in young epileptics.


A simple method for long-term intestinal and intravenous cannulation in animals.


Angiographic and microangiographic observations in experimental cerebral infarction.


Decorticate versus decerebrate rigidity in subhuman primates and man.


Cooperating clinics committee. Cyclophosphamide therapy of rheumatoid arthritis.


Incidence of antibodies to double-stranded RNA in systemic lupus erythematosus and related diseases.


Listings of health care institutions.

Listings of health care institutions.


Determination of proteins in biological fluids by electroimmunodiffusion and two-directional immunoelectrophoresis.


Actin: immunochemical and immunofluorescence studies.


Properties of the cytoplasmic membrane of Bacillus megaterium KM dissolved in various reagents.


Transcription and degradation of messenger ribonucleic acid for a glucose transport system in Neurospora.


Claim for improved food as civil right of persons injured by accident.


Presence of the Mycobacterium tuberculosis in the milk of experimentally reproduced sheep tuberculosis.


Activation and inhibition of the activities of bovine liver acontiase.


Biosynthesis of thiamine in plants. II. Biosynthetic pathway of thiamine monophosphate from pyrimidine and thiazole moieties.


Disintegration and storage of nitroglycerin tablets.


The serologic diagnosis of parasitic disease.


A new anticonvulsant in the management of minor motor seizures.


Effects of hypoxia on protein synthesis by cerebral ribosomes in monkey.


Coup and contrecoup cerebral contusions: an experimental analysis.


Osmotic inhibition of single neurons in the supraoptic nucleus of the unanesthetized monkey.


Bilateral acoustic neuroma (central neurofibromatosis): clinical and genetic studies.


Comparison of in vitro reactivity of cerebral and somatic arteries.


Studies on ceruloplasmin in Wilson's disease.


Protein synthesis in isolated nerve endings and brain mitochondria.


Anterior temporal cortex and maternal behavior in monkey.


Projected effects in focal epilepsy.

Projected effects in focal epilepsy.


The effect of delayed hyperventilation and experimental middle cerebral occlusion.


Angiographic changes in patients with seizures.


Demonstration of a nonspecific cholinesterase in retinal Müller cell.


The corneal reaction to selected chemical agents in the rabbit and squirrel monkey.


X-linked colobomatous microphthalmos and other congenital anomalies. A disorder resembling Lenz's dysmorphogenetic syndrome.


Assessment of ocular damage thresholds for laser radiation.


Glial nodules of the inner retina.

Glial nodules of the inner retina.


Demonstration of birch pollen allergen from isolated pollen grains using immunofluorescence and a single radial immunodiffusion technique.


Antigen in feed as cause of antibody in unimmunized animals.


A radial immune-gel filtration method for characterization and quantitation of macromolecules.


Interactions of Bacillus subtilis alkaline proteinases with alpha  2 -macroglobulin and alpha 1 -antitrypsin.


Clinical, immunochemical and serological studies of dementia paralytica (GPI).


Studies on the origins of 'tissue' antigens and enzymes in normal human urine.


Immunochemical studies on human chorionic gonadotropin (HCG). I. Characterization of HCG.


Antibody induced lysis of PPD-coated chicken erythrocytes by spleen cells of non-immunized guinea pigs.


Fatty acid composition of depot fat of the cow.


Morphological studies of the pelvic plexus of the pig.


Radiological, anatomical and histological studies of the mammary gland of the one-humped camel (Camelus dromedarius) I. The teat (papilla mammae).


Ultrastructure of transplantable melanotic and amelanotic melanoma of hamsters.


A critical study of monkey sera for the presence of antibody against the Marburg virus.


Concomitant occurrence of circumvallate placenta with single disc and bidiscoid placentas.


New approaches to preventing brain damage during asphyxia.


Use of ethanol in prevention of premature delivery.


Second look surgery after radiation therapy for advanced stages of cancer of the ovary.


A simple bolus mould for increasing surface dose with high energy beams.


Synchronous shielding and field shaping for megavolt irradiation of advanced cervical carcinoma.


Tissue maximum-dose ratio (Tmr) for 8 MV X rays.


Effect of nitrogen mustard on hyaluronate.


Genetic variation and evolution in the red cell carbonic anhydrase isozymes of macaque monkeys.


A sex-limited serum protein variant in the mouse: hormonal control of phenotypic expression.


Stimulation in vitro of microsomal aniline hydroxylation by 2,2'-bipyridine.


A new antibiotic?

A new antibiotic?


Protein toxins of Pasteurella pestis. Subunit composition and acid binding.


Serologic specificities of methylated base immune systems.


Penicillin-sensitive DD-carboxypeptidase from Streptomyces strain R 61.


Prenatal diagnosis and the prevention of birth defects.


Cyclic vaginal cytologic patterns in the Macaca mulatta.


A comparison of a new antigen from amastigotes of Trypanosoma cruzi and an antigen from epimastigotes for the diagnosis of Chagas' disease by the indirect immunofluorescence test.


Testicular dehydrogenases in toads after malonate treatment.


A histochemical investigation of non-specific esterase in brain tumours.


Contribution to the histochemistry of the carbonhydrates in the wall of the cardiac lymph vessels in bulls.


Histochemical studies on the enzymes of the uropygial gland.


Successful pregnancy following artificial hyperimmunization to hr'(c).


Intestinal malabsorption in macroglobulinemia.


Concerning the journal's abortion issue.


Cystic fibrosis: economic impact upon the family.


Model reactions for oxidative phosphorylation: sulfur compounds as carriers of the phosphoryl group.


Dual role of pyridoxal 5'-phosphate as chemical and conformation-determining active group in glycogen phosphorylase.


The 1968 outbreak of dengue in Vellore, Southern India.


Resistance of penicillins and cephalosporins to beta-lactamases from Gram-negative bacilli: some correlations with antibacterial activity.


Clinical significance of protein binding of the penicillins.


Clinical pharmacology of ampicillin and hetacillin.


Penicillin neurotoxicity.

Penicillin neurotoxicity.


Laboratory control of antibiotic therapy in urinary tract infection.


Clinical assessment of hetacillin in acute diarrhea of malnourished infants.


Effect of two brain specific proteins (S100 and 14.3.2) on cation diffusion across artificial lipid membranes.


Isolation of apolipoprotein-free lipoprotein lipase from human post-heparin plasma.


Multiple forms of  -1,4 glucan synthetase from spinach leaves.


T4-coliphage infection of Escherichia coli with defective cell envelopes.


Computer-based derivation of rate equations for enzyme-catalyzed reactions. I. Effects of modifiers on kinetics of multireactant systems.


The effects of sodium alginate on the absorption and retention of several divalent cations.


Sterility indicator with artificial resistance to ethylene oxide.


Temperature effects on the sorption of radionuclides by freshwater algae.


Glycoprotein coat of the TA 3  cell. I. Removal of carbohydrate and protein material from viable cells.


The formation of basal bodies (centrioles) in the Rhesus monkey oviduct. Basal body replication during estrogen-driven ciliogenesis in the rhesus monkey (Macaca mulatta) oviduct has been studied by stereomicroscopy, rotation photography, and serial section analysis. Two pathways for basal body production are described: acentriolar basal body formation (major pathway) where procentrioles are generated from a spherical aggregate of fibers; and centriolar basal body formation, where procentrioles are generated by the diplosomal centrioles. In both pathways, the first step in procentriole formation is the arrangement of a fibrous granule precursor into an annulus. A cartwheel structure, present within the lumen of the annulus, is composed of a central cylinder with a core, spoke components, and anchor filaments. Tubule formation consists of an initiation and a growth phase. The A tubule of each triplet set first forms within the wall material of the annulus in juxtaposition to a spoke of the cartwheel. After all nine A tubules are initiated, B and C tubules begin to form. The initiation of all three tubules occurs sequentially around the procentriole. Simultaneous with tubule initiation is a nonsequential growth of each tubule. The tubules lengthen and the procentriole is complete when it is about 200 mmicro long. The procentriole increases in length and diameter during its maturation into a basal body. The addition of a basal foot, nine alar sheets, and a rootlet completes the maturation process. Fibrous granules are also closely associated with the formation of these basal body accessory structures.


A dynamic model of the vertebrate retina.


Detection of bacterial deconjugation of bile salts by a convenient breath-analysis technic.


Growth and development of the fetal Rhesus monkey.


Cerebrovascular diseases: prevention, treatment, and rehabilitation. Report of a WHO meeting.


The presence of penicillin-G destroying enzymes among different bacteria.


The immunology of schistosomiasis.

The immunology of schistosomiasis.


A preliminary report on the interaction between concanavalin A and soluble extracellular polysaccharides produced by mutans- and sanguis streptococci.


A matter of personal and national values.


Effect of carotid sinus nerve stimulation on the heart of a patient with angina pectoris.


Identification of two lysine tRNA cistrons in Bacillus subtilis by hybridization of lysyl-tRNA with DNA.


The acceleration ballistocardiogram in relation to left ventricular flow in the baboon.


Carboxy-terminal structure of the   chain of human IgA myeloma proteins.


Skin response to a point source of fissioned uranium-235 carbide.


Comparative metabolism of radionuclides in mammals. V. Retention of  192 Ir in the mouse, rat, monkey and dog.


Experience with a low-cost chair-type detector system for the determination of radioactive body burdens of M.I.T. radiation workers.


Rectal cancer--to burn or not to burn.

Rectal cancer--to burn or not to burn.


Occurrence of pyruvic acid in capsular polysaccharides from various Klebsiella species. Capsular polysaccharide materials from several different klebsiella serotypes were demonstrated to contain an alpha-keto acid characterized as pyruvic acid. Linkage to the capsular polysaccharides was shown to be acid labile and alkali stable, suggesting ketosidic rather than ester linkages.


Dielectric study of the physical state of electrolytes and water within Bacillus cereus spores. Dielectric measurements revealed that dormant spores of Bacillus cereus have extremely low conductivities at high frequencies (50 MHz) and so must contain remarkably low concentrations of mobile ions both within the core and in the surrounding integuments. Activation, germination, and outgrowth were all accompanied by increases in conductivity of the cells and their suspending medium, and this result indicated that intracellular electrolytes had become ionized and leaked from the spores. High-frequency dielectric constants of spores were consistent with normal states for cell water. These values increased during successive stages of development from dormant spore to vegetative bacillus, and they could be directly related to increases in cell water content. In all, the results refuted a model of the dormant spore involving freely mobile, ionized electrolytes and supported a model involving electrostatically bound electrolytes.


Spore refractility in variants of Bacillus cereus treated with actinomycin D. Refractility as indicated by light microscopy, electron microscopy of thin sections, and freeze fracture etching was increased and maintained in a cortexless mutant, A(-)1, of Bacillus cereus var. alesti by the addition during sporulation stage 4 of actinomycin D, which prevents the terminal lysis of spore core associated with sporulation in this organism. (45)Calcium uptake levels and dipicolinic acid (DPA) content were similarly maintained. The location of these components appears to be in the spore protoplast. In the parent A(-), treated with actinomycin D during stage 4, spore particles with similar morphology to the mutant, that is without a cortex and with the characteristics of refractility, were obtained. A major difference in sensitivity to actinomycin D between the processes of (45)Ca uptake and DPA synthesis was observed. Some heat resistance in A(-) made cortexless by actinomycin D could be observed. These studies indicate that the role of the cortex is not to produce the dehydrated refractile spore state but to maintain it.


Protected environment units for the cancer patient.


Subarachnoid alcohol block in the control of pain.


Apparent lack of control by repression of arginine metabolism in blue-green algae. Five anabolic and two catabolic enzymes of arginine metabolism were neither repressed nor induced after inclusion of arginine in the growth medium of Anabaena variabilis.


The pathology of tumors. 2. Biopsy and diagnostic cytology.


Effect of sulfhydryl reagents on the ribosomes of Bacillus subtilis. The effect of various sulfhydryl reagents on the ribosomes of Bacillus subtilis was studied. The 70S ribosomes were completely dissociated into 30S and 50S subunits by appropriate concentrations of p-chloromercuribenzoic acid (PCMB) and 5,5'-dithio-bis-(2-nitro-benzoic acid). The N-ethylmaleimide and iodoacetamide failed to dissociate the ribosomes even at relatively high concentrations. The rate of dissociation of ribosomes by PCMB varied with the concentration of ribosomes. A progressive decrease in the rate of dissociation was observed as the concentration of ribosomes in the reaction mixture was increased. The PCMB-induced ribosomal subunits were unable to reassociate into 70S monomers unless they were dialyzed against buffer containing beta-mercaptoethanol. On the average, four molecules of PCMB per 70S ribosome and two molecules of PCMB per each 30S and 50S subunit were bound. The number of PCMB molecules bound per ribosome did not change with increasing concentrations of PCMB, even though higher concentrations of PCMB resulted in dissociation of ribosomes into subunits.


The submembranous fibrils of human blood platelets.


Streptomycin resistance in Bacillus megaterium.


Inhibition of mitochondrial protein synthesis in vivo by erythromycin in Schizosaccharomyces pombe and Saccharomyces cerevisiae.


Meningitis due to Listeria monocytogenes. A review of 25 cases.


Rescue of genetic markers from bacteriophage phi 29 DNA fragments.


The  -lactamases of gram-negative bacteria and their transfer by R-factors.


A stereotaxic method for repeated sessions of central unit recording in the paralyzed or moving animal.


Some effects of insecticides on hepatic microsomal enzymes in various animal species.


Regional blood-flow changes during 72-hour avoidance schedules in the monkey. Systemic and regional blood-flow measurements were made in five restrained monkeys before and during 72 hours of continuous work on an avoidance schedule. Systemic arterial pressures were elevated throughout the stress, initially owing to an increase in cardiac output, and after 72 hours owing to an increase in total peripheral resistance. Changes in the resistance in skeletal muscle blood vessels were closely related to these changes in total peripheral resistance.


Recommendations for parenteral nutrition.


A serological survey for Australia antigen and antibody.


Serratia marcescens bacteremia. Clinical observations and studies of precipitin reactions.


Psychopharmacology of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in squirrel monkey and rat.


Pharmacology of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam; Wy 4036).


Myelinated dendritic segments in the monkey olfactory bulb.


The fate of 2,5-dimethoxy-4-methylamphetamine (STP, DOM) in monkey and rat brains.


Efferent fiber connections of the dorsal and deep tegmental nuclei of Gudden. An experimental study in the cat.


Isoelectric separation of proteins after in vitro cultivation of sublingual tissue.


A clinical comparison of molindone hydrochloride with trifluoperazine in psychotic outpatients.


Combined administration of thioridazine and nicotinic acid in the treatment of geriatric patients.


A pilot study on the use of AL-1021 in the treatment of acute schizophrenics.


Anxious-depressed adults and problem children treated with thioridazine in private practice.


Evaluation of gentamicin with carbenicillin in infections due to gram-negative bacilli.


Treatment of pseudomonas infections in leukemic children with carbenicillin and colistin.


Pervenous fixed endocardial pacing: A short-term study in ten dogs.


Short-term use of oral and depo methylprednisolone in allergic rhinitis and asthma.


Effect of antacids on the Bernstein test in esophagitis.


The isolation of purified nuclear and chromatin fractions from chick intestinal mucosa.


Studies on cell deformability. Some rheological considerations.


Synchronized beating of and electrotonic transmission between myocardial cells mediated by heterotypic strain cells in monolayer culture.


Nonviability of sodium tetraphenylboron-dissociated cells.


Modification of alkylating agent-induced mutation frequencies in Bacillus subtilis.


Use of mutagens in the improvement of production strains of microorganisms.


A novel selective method for the production of Bacillus subtilis var. niger spores.


Selective media in air sampling: a review.


Symposium on microbial changes in foods. Application of microbial proteases to soybean and other materials to improve acceptability, especially through the formation of plastein.


Genetic transformation in Bacillus with respect to antibiotic production.


Ultrastructure of ciliary microtubules after critical point drying.


Source of the nonlinear dependence of bacteriophage SP82 transfection on deoxyribonucleic acid concentration. Extracts of competent cells of Bacillus subtilis exhibited nuclease activity on radioactively labeled cell deoxyribonucleic acid (DNA). The activity was not decreased when Mg was omitted from the reaction mixture but was decreased to zero by addition of ethylenediaminetetraacetic acid. Of the other metals tested, only Ca increased nuclease activity more than Mg. Addition of 1.5 x 10(-3)m Ca to transfection mixtures increased the nonlinearity of the relationship between number of transfectants and DNA concentration. The inferred role of the Ca-activated nuclease was checked by showing that the ultraviolet enhancement of transfection is reversed by addition of Ca. It was also shown, by testing in three different laboratories, that the Ca ion in water is the likely source of the different nonlinear relationships found in different laboratories.


Biliary lipid secretion and bile composition after acute and chronic interruption of the enterohepatic circulation in the Rhesus monkey. IV. Primate biliary physiology. Bile salts and phospholipids are both required to solubilize biliary cholesterol. Since interruption of the enterohepatic circulation (EHC) depletes bile of bile salts, we have examined in the rhesus monkey the effects of controlled interruption of the EHC on biliary secretion of bile salt, phospholipid, and cholesterol and on the relative proportions of these components in bile. Immediately after complete interruption of the EHC, bile secretion and bile composition remained normal for 2-3 hr. During the next 3 hr, however, secretion of all components decreased. Bile salt decreased to a greater extent than phospholipid and cholesterol, and the bile was now supersaturated with cholesterol. 12-24 hr after interruption of the EHC, a new steady state was reached in which there was a relative deficiency of bile salt and a relative increase in phospholipid and cholesterol. The resulting bile, although somewhat more saturated with cholesterol, was not supersaturated with cholesterol but was stable with respect to cholesterol solubility. Thus, bile instability conducive to gallstone formation occurs transiently within hours after interruption of the EHC. Prolonged large interruptions in the steady state animal also produce a relative bile salt deficiency, but in this situation cholesterol remains soluble in the bile of these animals because there occurs a concomitant relative increase in phospholipid. When the EHC was only partially interrupted, secretion rates and the relative concentration of bile salt, phospholipid, and cholesterol did not change significantly from control values until more than 20% of the bile was diverted. Modest changes in the relative composition of bile occurred when 33 and 66% of the bile was diverted, and these changes were very similar to those produced by resection of the distal small bowel.


Transformation of murine cells by two "slow viruses," visna virus and progressive pneumonia virus. Visna and progressive pneumonia virus (PPV), two antigenically related, non-oncogenic "slow viruses" which have ribonucleic acid (RNA)-dependent deoxyribonucleic acid (DNA) polymerase activity, were examined for their ability to transform cells. Murine cells which had been exposed to either visna or PPV developed foci of altered, spindle-shaped cells 3 to 4 weeks after infection. Visna and PPV transformed lines were established from these cultures. There was no evidence that other oncogenic DNA or RNA viruses were involved in the observed transformation. Visna or PPV could be "rescued" from all transformed lines by co-cultivation with normal sheep testis cells. "Rescued" virus was identified as visna or PPV, and they retained the capacity to transform mouse cells. These experiments may have important implications in the understanding of both viral carcinogenesis and "slow" viral infections.


Inhibition of ribonucleic acid bacteriophage release from its host by rifampin. Rifampin, in addition to interfering with intracellular growth of the ribonucleic acid-containing phage MS2, also inhibits the release of mature phage particles from Escherichia coli cells.


Radiotherapy as initial treatment for epidermoid carcinoma of tonsil and base of tongue.


Gentamicin, theoretical and applied microbiology.


South American Trypanosomiasis (Chaga's disease) within the concepts of immunopathology.


Neuron activity related to short-term memory. Nerve cells in the monkey's prefrontal cortex and nucleus medialis dorsalis of the thalamus show changes of firing frequency associated with the performance of a delayed response test. Most cells increase firing during the cue presentation period or at the beginning of the ensuing delay; spike discharge highler than that in intertrial periods is present in some cells throughout the delay. These changes are interpreted as suggestive evidence of a role of frontothalamic circuits in the attentive process involved in short-term memory


Variation and homology in the mu and gamma heavy chains of human immunoglobulins. Sequence analysis of an 1gM immunoglobulin shows that the variable regions of hunman micro and gamma1 heavy chainis may have twice as much homology as their constant regions and that evolutionary divergence of micro and gamma1 heavy chain genes occurred not long after the separation of heavy and light chain genes.


WHO expert Committee on Malaria. Fifteenth report.


Application and dispersal of pesticides. Eighteenth report of the WHO Expert Committee on Insecticides.


Summary of recent abstracts. VII. Rickettsial diseases.


Preparation and standardization of an Australia antigen antibody of equine origin. A horse has been immunized with Australia antigen (Au/SH) purified 20-fold by a procedure employing gel filtration of Cohn fraction IV derived from an Au/SH-positive human plasma pool. Hyperimmunization was initiated by the intramuscular injection of 20 ml of a mixture of equal parts of purified Au/SH and complete Freund's adjuvant. The 20-ml volume was divided into four 5-ml doses, two of which were administered on each side of the horse's neck. Booster doses of antigen alone were given as follows: 10 ml intravenously 30 days later and 5 ml intramuscularly on each of days 77 and 205. Au/SH antibody formed readily, beginning on day 17, and was demonstrated by the agar gel double-diffusion technique and the complement fixation test during the subsequent 6 months. Antihuman plasma protein antibodies were effectively removed from the horse serum by one absorption with 1 to 3 volumes of normal human plasma. Abrupt rises in anticomplementary activity observed shortly after the third and fourth antigen injections, when the horse had developed elevated and steady levels of Au/SH antibody, could possibly be due to formation of antigen-antibody complexes. After optimal conditions were determined, an Au/SH antibody reagent pool which met official requirements was prepared. It was found equally suitable for the agar gel double-diffusion, complement fixation, and counterimmunoelectrophoresis test procedures.


Virulence and pathogenesis of yellow fever virus serially passaged in cell culture. Viscerotropic virulence of the Asibi strain of yellow fever virus (YFV) for monkeys has been known to be lost after serial passage in HeLa cell monolayers. This phenomenon was investigated in several other mammalian and insect tissue cell lines. Assay in monkeys of original seed virus and of virus after 7 and 11 passages in a porcine kidney cell line (PK) indicated essentially equal infectivity and mortality. Moreover, monkeys receiving the passaged virus exhibited more rapid onset of disease and death than animals infected with original seed virus. Histological changes in animals inoculated with passaged virus were identical to those in animals receiving the seed virus. Virus from later passages in PK cells was also lethal for approximately 50% of the monkeys; however, evidence for progressive attenuation was seen in these preparations. Similar results were obtained with a mosquito (Aedes aegypti) cell line. In contrast to results obtained in PK and mosquito cells, YFV became essentially avirulent (nonlethal and less infective) for monkeys after only seven passages in HeLa cell cultures.


Resistance of Pseudomonas to quaternary ammonium compounds. II. Cross-resistance characteristics of a mutant of Pseudomonas aeruginosa. Tube dilution experiments showed that benzalkonium chloride (BC)-resistant mutants of Pseudomonas aeruginosa grown in the presence of 1,000 mug of BC per ml were at least 20 times more sensitive to polymyxin B and colistin sulfate than the BC-sensitive (BCS) parent strain. BCS cells selected for resistance to 500 mug of polymyxin B per ml remained sensitive to BC. There was little difference in the amount of carbenicillin, gentamicin sulfate, or rifampin needed to prevent growth of either the BCS or BC-resistant (BCR) strains. Growth of BCR cells was inhibited by ethylenediaminetetraacetate at a concentration of 400 mug/ml or less, whereas the BCS strain grew at ethylenediaminetetraacetate levels of 10,000 mug/ml. Phenylmercuric acetate and thimerosal inhibited growth of BCR and BCS cells at concentrations of 10 mug/ml or less. BCR cells were cross-resistant to >1,000 mug/ml concentrations of five other quaternary ammonium compounds, including three with C(16) alkyls and two with alkyl groups of shorter length. The BCS strain was also resistant to >1,000 mug/ml concentrations of the three quaternary ammonium compounds with C(16) alkyl groups but, in addition to BC, was inhibited by 200 mug/ml levels or less of the two quaternary ammonium compounds containing alkyl groups of less than 16 carbon atoms.


Effect of toxin concentration on the heat inactivation of staphylococcal enterotoxin A in beef bouillon and in phosphate buffer. The slope of the thermal inactivation curve of enterotoxin A in beef bouillon (initial pH 6.2) was found to be approximately 27.8 C (50 F) with three different concentrations of toxin. Inactivation by heat was dependent on the concentration of enterotoxin A heated. Enterotoxin A was inactivated by less heat in a pH 7.2 phosphate buffer than in beef bouillon as detected by serology. Results indicate that natural (usually low) levels of toxin rather than concentrated enterotoxin A should be used in heat inactivation studies.


Selective mycobacteriophage isolation with membrane filters. A simple technique is described whereby mycobacteriophages are selectively isolated by adsorption on mycobacteria layered within membrane filter sandwiches before standard enrichment procedures.


Self-sterilizing inoculating loop.

Self-sterilizing inoculating loop. A self-sterilizing inoculating loop consisting of a step-down transformer and an adjustable timing circuit are described.


Attempts to demonstrate hemagglutination and hemadsorption by respiratory syncytial virus. Extensive attempts to demonstrate a hemagglutinin of respiratory syncytial virus by both hemagglutination and hemadsorption tests failed. Hemagglutination tests were performed with red blood cells from 12 different animal species and at various temperatures and pH.


Antigenic analysis of Rhizobium japonicum by immunodiffusion. Immunodiffusion reactions were studied with seven strains of Rhizobium japonicum and three strains of the cowpea miscellany by using antisera against eight of the strains. Most strains yielded only weak precipitin bands when untreated cell suspensions were used as antigens in the diffusions. Ultrasonic disruption or heat treatment of the cells led to stronger bands, and immersion in boiling water for 20 min was used as the standard procedure for preparing these bacteria for immunodiffusion analysis. Heat-labile antigens were detected in only a few strains; the major antigens of all of the strains appeared to be heat-stable. Many of the strains cross-reacted, sometimes in a nonreciprocal manner; unheated cell suspensions cross-reacted more widely but more weakly than the heated suspensions. Heat-treated crushed nodule preparations reacted well in immunodiffusions. The antigens of cultured cell and nodule extract (bacteroid) forms of three strains were compared. In one of these strains, an antigen present in the cultured cells was absent from the bacteroids. Unknown strains present in soybean root nodules were readily identified by immunodiffusion.


Treatment of lead poisoning at Yale-New Haven Hospital 1970.


A choice for hospital administrators: minimizing costs or maximizing benefits.


Absorption studies on intraluminal thio-tepa for topical cytostatic treatment of low-stage bladder tumors.


Studies of cardiac muscle with a high permeability to calcium produced by treatment with ethylenediaminetetraacetic acid. Thin strips of frog ventricle were isolated and bathed for 15 min in a solution containing 140 mM KCl, 5 mM Na(2)ATP, 3 mM EDTA, and 10 mM Tris buffer at pH 7.0. The muscle was then exposed to contracture solutions containing 140 mM KCl, 5 mM Na(2)ATP, 1 mM MgCl(2), 10 mM Tris, 3 mM EGTA, and CaCl(2) in amounts to produce concentrations of free calcium from 10(-4.8)M to 10(-9)M. The muscles developed some tension at approximately 10(-8)M, and maximum tension was achieved in 10(-5)M Ca(++). They relaxed in Ca(++) concentrations less than 10(-8)M. The development of tension by the EDTA-treated muscles was normalized by comparison with twitch tension at a stimulation rate of 9 per min before exposure to EDTA. In 10(-5)M Ca(++) tension was always several times the twitch tension and was greater than the contracture tension of a frog ventricular strip in KCl low Na-Ringer. Tension equal to half-maximum was produced at approximately 10(-6.2)M Ca(++). Intracellular recording of membrane potential indicated that after EDTA treatment the resting potential of cells in Ringer solution with 10(-5)M Ca or less was between 5 and 20 mv. Contracture solutions did not produce tension without prior treatment with EDTA. The high permeability of the membrane produced by EDTA was reversed and the normal resting and action potentials restored in 1 mM Ca-Ringer. Similar studies of EDTA-treated rabbit right ventricular papillary muscle produced a similar tension vs. Ca(++) concentration relation, and the high permeability state reversed with exposure to normal Krebs solution.


Bacterial hitch-hikers.

Bacterial hitch-hikers.


The flavin-sensitized photooxidation of nucleotides. II. The participation of the flavin triplet state.


Sensitivity of Neisseria meningitidis to rifampin, penicillin, and sulfadiazine.


Purification and properties of unicellular blue-green algae (order Chroococcales).


Radiocesium retention by rats as affected by L-thyroxine and propylthiouracil.


A developmnetal scintillation counter for detection of plutonium in vivo.


Estimation of  241 Am body burdens by analysis of whole-body scanning, excreta, and body weight data.


Body elimination rates of  134 CDs,  60 Co and  203 Hg.


Serological reactions in growing pigs to infections with Hyostrongylus rubidus. I. Precipitating antibody.


An experimental examination of the scrapie agent in cell membrane mixtures. 3. Studies of the operational size.


The analysis of spatial distributions in mixed cell populations: a statistical method for detecting sorting out.


The identification of seminal stains by immunodiffusion on cellulose acetate.


A case of sero-positive primary syphilis of the tonsil.


Primary carcinoma arising in the epiphrenic esophageal diverticulum.


Influence of level of ligation on the results of vena caval interruption.


Pyocine typing of Pseudomonas aeruginosa: association between antigenic structure and pyocine type.


Hyperglycaemia due to phenytoin toxicity.


Atypical mycobacteria isolated from diagnostic material.


Raised serum IgM levels in neonatal endemic diarrhoea.


Prophylaxis of epidemic infantile pneumocystosis with a 20:1 sulfadoxine+pyrimethamine combination.


Effects of clonidin and chlorthalidone on blood pressure and glucose tolerance in hypertensive patients.


The treatment of urinary tract infections with sulfacytine, a new soluble sulfonamide.


Agreement on specificity of psychotropic drugs.


The clinical effects of intramuscular thiothixene and trifluoperazine in chronic schizophrenia: a comparative study.


Senilex in the treatment of geriatric patients.


The treatment of psychoneurotic states: a study of thioridazine in an office practice.


Ketipramine fumarate as compared to imipramine in depressed outpatients.


Radioimmunoassay of triiodothyronine in unextracted human serum.


Immunochemical studies on serum lacking in thyroxine-binding globulin.


A ase report of perforated jejunal diverticulum.


The diagnosis and treatment of fat embolism.


Relationship of arterial blood gases and pulmonary radiographs to the degree of pulmonary damage in experimental pulmonary contusion.


2,3-diphosphoglycerate affects enzymes of glucose metabolism in red blood cells.


Does 'care' cure?

Does 'care' cure?


Malaria and other febrile conditions.

Malaria and other febrile conditions.


Amoebic and bacillary dysentery and the enteric fevers.


Trypanosomiasis and leishmaniasis.

Trypanosomiasis and leishmaniasis.


The polypeptide composition of influenza A viruses.


[Anatomy and histoenzymology of the thalamus].


The vascularization of the human thalamus.


A potential clinical use for methylphenidate with tricyclic antidepressants.


Isolation and characterization of nucleic acids from Volvox carteri.


Long-term group work with hospitalized aged.


Defective deiodination of 131-I-labeled L-diiodotyrosine in a family with cases of euthyroid goiter and hyperthyroidism.


Comparative studies of the Lp(a)-lipoprotein and low density lipoproteins of human serum.


Isolation and partial characterization of  -glucuronidase from murine mastocytoma cells.


Sen. Kennedy explains his Health Security Act.


The relative concentration of infective intact virus and RNA of four strains of tobacco mosaic virus as influenced by temperature.


Treatment of gonorrhea.

Treatment of gonorrhea.


Serum cholesterol in monkeys with chronic epileptic foci.


Experiences in laboratory diagnosis of mumps virus infections in routine medical practice.


Constant production of type C virus particles in a continuous tissue culture derived from pleural effusion cells of a lymphoma patient.


Brief lapses of consciousness in children.


Evaluation of retinal thresholds for C.W. laser radiation.


Clinical pharmacologic studies with minocycline.


Effect of age on erythrogram values of thoroughbred horses from 1 to 12 months of age.


Complications in halothane anaesthesia of cattle.


Troxonium tosylate in drug-induced Parkinsonism: a controlled comparative study.


Effect of chloral hydrate and related compounds on the activity of several enzymes in extracts of rumen microorganisms.


Effects of (2-chloroethyl)-trimethylammonium chloride on the electrocardiogram of the rabbit.


Inheritance of some of the economic traits of Italian Friesian cattle. I. Heritability of age at first calving, first lactation yield and first lactation length.


Studies on chemical constituents of bull semen. IV. Semen cholesterol in normal and PMSG treated bulls.


Some biochemical and pharmacological actions of  -methylphenylalanine.


Inhibition of histidine decarboxylase and diamine oxidase by 4-bromo-3-hydroxybenzyloxyamine.


Interference of barbiturates with pyrimidine incorporation. 3. Studies on the mechanism of the amobarbital-orotate relationship.


Interaction of serotonin with the catecholamines. I. Inhibition of dopamine and norepinephrine oxidation.


Interaction of serotonin with the catecholamines. II. Activation and inhibition of adrenochrome formation.


Purification and characterization of monkey placental lactogen.


Effect of protein deficiency on plasma progesterone levels during the menstrual cycle of adult rhesus monkeys.


Thyroid hormone binding proteins and acute psychniatric illness.


14 C-5-hydroxytryptamine and  3 H-D-amphetamine: uptake and contraction by the rat stomach fundus in vitro.


Hypothalamic mediation of growth hormone and adrenal stress response in the squirrel monkey.


Estrogen and progesterone regulation of carbonic anhydrase isoenzymes in guinea pig and rabbit uterus.


Membrane-associated protein synthesis of mammalian cells. I. The two classes of membrane-associated ribosomes.


Stimulation of 14-C-glucosamine and 14-C-alanine incorporation into thyrotropin by synthetic thyrotropin-releasing hormone.


Membrane-associated protein synthesis of mammalian cells. II. Isopycnic separation of membrane-bound polyribosomes.


Attempts to modify the intestinal villus architecture in mice.


Viral and bacterial meningitis.

Viral and bacterial meningitis.


Primary carcinoma in diverticulum of female urethra.


Infections of Scribner and Brescia arteriovenous shunts. The incidence of infections of Scribner shunts and Brescia fistulae in patients receiving intermittent haemodialysis was compared. In both groups infection was most commonly due to Staphylococcus aureus and was associated especially with carriage of this organism on the skin of the limb where the shunt or fistula was sited. The incidence of local infection was much less with the Brescia fistula but this was accompanied by a relatively higher incidence of septicaemia.


Bone density and long-term anticonvulsant therapy.


Psychogeriatric care.

Psychogeriatric care.


Influence of V.D.S. (diffusible killed antitubercular vaccine Salvioli) on the course of experimental tuberculosis in guinea-pigs evoked by H 37 Rv strain bacilli.


Effects of prostaglandins and a prostaglandin antagonist on intraocular pressure and protein in the monkey eye.


The use of various extracts of Brucella abortus for haemagglutination test in brucellosis.


Methadone treatment of narcotic addiction.


Critical issues in continuing education in nursing: determining needs and priorities.


Extending the nursing role in a patient care setting.


New aspects of hepatitis.

New aspects of hepatitis.


Bacillus subtilis septicemia: report of two cases.


Kinetics of the two-sited enzyme. I. Activation and inhibition by substrate.


Rationale for a hospital-wide department of educational resources.


From a mustard seed.

From a mustard seed.


Hemolytic anemia associated with cephalothin.


Issues in continuing education in nursing.


A midwest organization forms to promote continuing nursing education.


Extended care.

Extended care.


Continuing education--whose responsibility?


An interprofessional approach to continuing education in the health sciences.


On the unified laws of excitability, activity and interactivity of physiological systems.


The Rhesus Unit at Lewisham. II.

The Rhesus Unit at Lewisham. II.


Obvious seizures from carbenicillin.

Obvious seizures from carbenicillin.


Role of Rho(D) immune globulin in induced abortions.


Studies on tuberculous-like lesions in slaughtered camels.


An internist looks at myocardial revascularization.


Absorption, excretion, and biotransformation of procainamide-C 14  in the dog and rhesus monkey.


Changes in saccadic eye movements produced by cerebellar cortical lesions.


The structure of viscosin, a peptide antibiotic. I. Syntheses of D- and L-3-hydroxyacyl-L-leucine hydrazides related to viscosin.


Homotopic and nonhomotopic interhemispheric cortical projections in the squirrel monkey.


Antitumor activity of 5-substituted 3-(1'-anilinoethylidene)pyrrolidine-2, 4-dione.


Diuresis and prostatectomy.

Diuresis and prostatectomy.


Properties of   1 -acid glycoprotein from ascitic fluids.


Lymphographic procedure in cats and rhesus monkeys.


Alterations of red-cell glycolytic intermediates and oxygen transport as a consequence of hypophosphatemia in patients receiving intravenous hyperalimentation.


The chick embryo neutralization test in the assay of meningococcal antibody. 3. Dynamics and specificity of the sero-protection test.


Pathogenicity of vegetative cells of Bacillus popilliae fro mice.


Hemifacial microsomia.

Hemifacial microsomia.


The effect of caffeine and light on killing of the blue-green alga Anabaena doliolum by ultraviolet radiation.


Pulmonary oxygen toxicity. A review of the evidence for acute and chronic oxygen toxicity in man.


Mathematical relationship of in vitro release rates and biological availability of controlled-release nitroglycerin (nitrong).


Studies on the non-collagenous proteins of bone.


Bone remodeling after tooth extraction.

Bone remodeling after tooth extraction.


Structural and ultrastructural organization of biological hard and soft tissues. A unified concept.


Proteinuria and renal protein clearances in patients with renal tubular disorders.


Induced abortion.

Induced abortion.


Experimental infections of Rickettsia prowazeki among domestic livestock and ticks.


Rate of destruction of Schistosoma mansoni eggs and adult worms in the tissues of rhesus monkeys.


A study of sociopsychologic needs of institutionalized chronically ill and aging patients.


Long-term intravenous hyperalimentation.


Clinic for patients with long-term diseases (LT-patients).


An ergot preparation (hydergine) in the treatment of cerebrovascular disorders in the geriatric patient: double-blind study.


Experimental hypertensive retinopathy: circulatory changes.


A new human virus in cultures from a nasopharyngeal carcinoma.


Histochemical studies of growing human cartilage in Morquio's disease.


Experimental hypertensive retinopathy: ultrastructure.


Cortisol production in epileptic patients treated with diphenylhydantoin.


Peripheral intravenous alimentation of the small premature infant.


Propranolol and other anti-anginal drugs.


Morphogenesis of the palate in the baboon (Papio cynocephalus).


Plasmodium vivax infections in Aotus trivirgatus.


Pichindé virus, a new virus of the Tacaribe group from Colombia.


Introducing a new drug into clinical practice.


The gonococcal arthritis-dermatitis syndrome.


Bacillemia in primary tuberculosis.

Bacillemia in primary tuberculosis.


Some implications of conditioning theory for problems of drug abuse.


A rapid method for removal of zinc from the metallo neutral proteases.


Utilization of deoxyribonucleoside triphosphates in the cellular synthesis of DNA by Bacillus subtilis.


Experimental aeromonas hydrophila infection in rabbits.


Erythrocyte sedimentation rate studies in sheep, dog, and horse.


Studies on passive cutaneous anaphylaxis in the rat with disodium cromoglycate. II. A comparison of the rat anti-dnp 7S  2  and rat reagin induced cutaneous reactions.


Observations on the reactions between D-positive red cells and ( 125 I)IgM anti-D molecules and subunits.


Comparison of the latex slide agglutination and complement fixation tests for the diagnosis of Chagas' disease.


Analyses of supernatant fluids from exsheathing infective Haemonchus contortus cayugensis larvae.


The effect of antibody on the permeability control of larval Taenia taeniaeformis.


Centrifugal elutriation for the removal of leukocytes from malaria-infected monkey blood.


Nosematosis in carnivores.

Nosematosis in carnivores.


Ultrastructure of mammalian spermiogenesis. II. Elimination of the nuclear membrane.


The rhesus unit at Lewisham. 1.

The rhesus unit at Lewisham. 1.


Prophylaxis of gonococcal ophthalmia.

Prophylaxis of gonococcal ophthalmia.


Traumatic epilepsy with reflex and conditioned paroxysms.


Biologicl activity and synthesis of an encephalitogenic determinant. A 45-residue fragment of the basic protein of myelin is encephalitogenic in the rabbit and monkey but relatively inactive in the guinea pig. Synthetic peptides containing the sequence of a tryptic peptide of the fragment Thr-Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys are moderately encephalitogenic.


Invagination of the stomach into the esophagus in a dog.


Growth regulation in mouse epidermis. I. G 2 -inhibitor present in the basal cell layer.


Fine structural aterations of thyroid C-cells in response to diet-induced hypocalcemia and vitamin D in adult cows.


Tubular damage caused by local thermal injury or microembolization of the rat testis.


Circadian variations of DNA synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver.


Growth of elementary blood vessels in diffusion chambers. II. Electron microscopy of capillary morphogenesis.


Ultrastructural modifications of mitochondria and rough endoplasmic reticulum of liver and spleen after a period of hypoxia.


Cytomembrane differentiation in a ciliate, Tetrahymena pyriformis. I. Endoplasmic reticulum and dictyosomal equivalents.


Gonococcal arthritis in an adolescent girl.


Ultramicroanalysis of pH, p CO2 and carbonic anhydrase activity at calcifying sites in cartilage.


Transspecific variability of phosphohexose isomerase (E.C.:5.3.1.9) in primates.


Considerations from a bacterial ecorelation viewpoint in an acute respiratory infection focus.


Hypersensitivity pneumonitis related to a home furnace humidfier.


Precipitins and the diagnosis of a hypersensitivity pneumonitis.


Rabbit secretory IgA. I. Isolation of secretory component after selective dissociation of the immunoglobulin.


Immunochemical studies on bovine carboxypeptidases A.


Studies on the absorption, distribution and excretion of propranolol in rat, dog and monkey.


Coronary vasodilatation produced by dopamine after adrenergic blockade.


Comparative profile of L 3428 and other antianginal agents on cardiac hemodynamics.


The renal mechanisms for the excretion of m-hydroxybenzoic acid in Cebus monkeys: relationship to urate transport.


Nalorphine-induced changes in morphine self-administration in rhesus monkeys.


Effects of two tetrahydrocannabinols and of pentobarbital on cortico-cortical evoked responses in the squirrel monkey.


Effects of lanthanum on  45 Ca movements and on contractions induced by norepinephrine, histamine and potassium in vascular smooth muscle.


Pharmacologic analysis of the hypothermic responses of the morphine-dependent rhesus monkey.


Hemodynamic effects of nitroglycerin and amyl nitrite in the conscious dog.


Vascular disease in the intensive care unit.


Endocrine emergencies: diagnosis and intensive care.


Chromosom replication in toluenized Bacillus subtilis cells.


Correlation of 30S ribosomal proteins of Escherichia coli isolated in different laboratories.


Enzymatic preparation of L-tyrosine and 3,4-dihydroxyphenyl-L-alanine.


Studies on inosine-5-phosphate dehydrogenase of Bacillus subtilis. Purification and general properties.


A kinesthetic deficit after partial transection of a pyramidal tract in monkeys.


Solubilization, purification, and properties of a hepatic epoxide hydrase.


Delta-aminolevulinic acid dehydratase of Mycobacterium phlei.


The relevance of natural stimulus patterns for sensory information processes.


Response properties of auditory cortical cells.


Human visual evoked potentials (VEPs) to pattern stimuli.


Perception of naturalistic stimuli in patients with focal brain lesions.


Effects of frontal eye-field ablation on visual fields and on fixation in rhesus monkeys.


Veridical and paradoxical interocular transfer of left-right mirror image discriminations.


Experimental alterations of neurofilaments and neurotubules by calcium and other ions.


Transient production of anti-LW by LW-positive people.


Increasing the crown-root ratio with endodontic pin implants.


Dental responsibilities for senior citizens.


The Arbitration Committee.

The Arbitration Committee.


Multiple cementomas. Case report.

Multiple cementomas. Case report.


A G.P. observes blade-vent implants.

A G.P. observes blade-vent implants.


Professional liability insurance. Cancellation or continuation. Current status of malpractice insurance.


Ethanol induced notochord and spinal cord duplications in the embryo of the zebrafish, Brachydanio rerio.


Management of acute oral infections.

Management of acute oral infections.


Home care - whose decision? Fiscal intermediary viewpoint.


Experimental transfusion reactions and disseminated intravascular coagulation produced by incompatible plasma in monkeys.


A short revue of oculo dental syndromes.


Carcinoma of the bladder. Cystectomy after supervoltage therapy.


A case of acute glomerulonephritis and severe uraemia, treated with heparin and corticosteroids.


The effects of chelating agents on the tissue distribution and excretion of lead.


Toxicity evaluation of trisodium nitrilotriacetate.


Metabolism of nitrilotriacetic acid (NTA).


Hypothalamic controls on feeding behavior as revealed by a "disconnection" method.


Motor disorders following medullary pyramidal tract section in the monkey.


The descending trigeminal tract as a mechanism for intersegmental sensory facilitation.


Central neurogenic control of cerebral blood flow.


Stiff muscles and bony tendons.

Stiff muscles and bony tendons.


Question of transcallosal facilitation of motor recovery: stroke implications.


Temporary focal ischemia in the monkey.

Temporary focal ischemia in the monkey.


Movements of the brain and brain stem from impact induced linear and angular acceleration.


Trimodal inattention following parietal lobe ablations.


The termination of callosal fibers in the rhesus monkey.


The pathophysiology of obstructive hydrocephalus in the monkey.


An experimental model of "petit mal epilepsy" in the monkey: additional studies of the anterior premotor area.


Nucleus of the accessory optic tract: electron microscopic analysis in normal and eye-enucleated monkeys.


Electroimmunodiffusion: a simple, rapid, reliable, and valid method for the simultaneous determination of cerebrospinal fluid and serum immunoglobulin-G and albumin.


An ultrastructural study of lesions induced by sodium azide in the primate brain.


Analysis of deaths in Parkinson patients on long-term levodopa therapy.


Experimental ammonia encephalopathy in the primate.


Hypothalamic osmosensitive single neurons in the waking monkey.


Proton tunneling and enzyme catalysis.

Proton tunneling and enzyme catalysis.


Hierarchy of organization in eukaryotic chromosomes (a review).


Tumorous head in Drosophila.

Tumorous head in Drosophila.


Fractionation of staphylococcal enterotoxin B by isoelectric focusing.


Isolation and characterization of subunit polypeptides from apoproteins of rat serum lipoprotein.


Purification and quantitation of the human plasma lipoprotein carrying the Lp(a) antigen.


The reaction of 4-(p-trimethylammoniumphenylazo)-2-hydroxymercuriphenol with the thiol groups of proteins.


In vitro labeling of polynucleotides by photoreduction.


A procedure for rapidly extracting and estimating the nuclear and cytoplasmic DNA components of yeast cells.


Studies on Christmas disease: investigation and treatment of a familial acquired inhibitor of factor IX.


The role of macromolecular components in anti-gamma, alpha, mu, kappa, lambda, C3 and C4 antiglobulin sera.


Rh antibody quantitation in amniotic fluid.


The use of modified cells to indice an anti-Rh response.


Bacteria in cream.

Bacteria in cream.


Renal artery dysplasia with hypertension in neurofibromatosis.


Multiple molecular forms of avian aldolases. V. Purification and molecular properties of chicken (Gallus domesticus) liver aldolase.


Method of removing abnormal protein rapidly from patients with malignant paraproteinaemias. On 48 occasions large quantities of abnormal protein were removed from the blood of 11 patients with malignant paraproteinaemias (plasmacytomas) by exchanging their plasma with reconstituted blood bank plasma. The IBM continuous flow blood cell separator was used to exchange the plasma, a procedure that is safe, very rapid, and with clinical benefits which are much better than can be obtained by conventional plasmapheresis. In addition, the constituents of reconstituted plasma correct deficiencies in normal immunoglobulins found in these patients. Clearly for the management of some patients with paraproteinaemia a cell separator is essential.


Multiple molecular forms of avian aldolases. VI. Enzymatic properties and amino acid composition of chicken liver aldolase and comparative immunochemical properties.


The clinical development of prolonged endotracheal intubation.


Tissue testing of polymers.

Tissue testing of polymers.


Plastics for tracheal tubes.

Plastics for tracheal tubes.


Rubber for tracheal tubes.

Rubber for tracheal tubes.


Prolonged endotracheal intubation in children: a perspective.


Tissue toxicity from rubber endotracheal tubes.


Prolonged tracheal intubation for facilitation of tracheobronchial toilet and the treatment of atelectasis.


A new assay for histaminase activity: measurement of tritiated water from beta (side chain label)-H 3-histamine.


Effect of nitroglycerin and dipyridamole on epicardial and endocardial oxygen tension--further evidence for redistribution of myocardial blood flow.


Morphology and distribution of intracellular schizonts in chickens experimentally infected with Akiba caulleryi.


Catalase and peroxidase activity of INH-sensitive and INH-resistant tubercle bacilli.


Gossypol: subcellular localization and stimulation of rat liver microsomal oxidases.


An investigation into the teratogenic potential of captan, folpet, and Difolatan in nonhuman primates.


Studies on the thermal dissociation of glycerol dehydrase.


Stress disorders of modern life.

Stress disorders of modern life.


Molecular weight of bovine fibrinogen by sedimentation equilibrium.


Purification and properties of an inhibitor of microbial alkaline proteinases from barley.


Comparative studies on structural and catalytic properties of enolases.


The problem of somatic plasticity in the theory of evolution.


Pancreatitis complicated by pericardial effusion and cardiac tamponade. Recovery after prolonged cerebral anoxia.


Biosynthesis of cardiolipin in liver mitochondria.


A purified killed Brucella abortus vaccine.


The growth of the virus of epidemic diarrhoea of infant mice (EDIM) in organ cultures of intestinal epithelium.


The design of a practical fast neutron therapy equipment for routine clinical use.


Subcutaneous emphysema and pneumomediastinum in diabetic keto-acidosis.


Considerations on the use of 14 MeV neutrons for radiotherapy.


A 14 MeV neutron tube for radiotherapy.

A 14 MeV neutron tube for radiotherapy.


William Murrell, physician and practical therapist.


Neurofibromatosis with leukaemia.

Neurofibromatosis with leukaemia.


Lactoferrin in milk from different species.


Serum esterase diversity in mice of the genus Peromyscus.


Diisocyanates for reappraisal.

Diisocyanates for reappraisal.


Photolysis of 1-alpha-methylallylthiocarbamoyl-2-methylthiocarbamoylhydrazine (methallibure) to a thiadiazole in the presence and absence of rumen microorganisms.


Immunisation of laboratory animals and cattle with non-agglutinogenic extracts of Brucella abortus strain 45-20.


The demonstration and significance of synergism between  -lactam antibiotics.


Studies of the geographical spread of drug-resistant tubercle bacilli in a city.


Antibodies to gonococcal lipopolysaccharides in patients with gonorrhoea.


Amelioration of cyclophosphamide-induced cystitis.


Characterisation of the Pseudomonas aeruginosa factor that inhibits mouse-liver mitochondrial respiration.


Chronic manganism. Neurologic and laboratory studies during treatment with levodopa.


[The effects of antituberculosis chemotherapy in vitro under various conditions inadequate for the growth of tubercle bacilli. II. Antituberculosis activity of INH and SM in vitro after exposure to PAS].


Drug sensitivity pattern of mycobacteria isolated in Pondicherry.


Mechanism of antiviral activity in vivo of polycarboxylases which induce interferon production.


Ultrastructural changes in the parathyroid gland of the rabbit following EDTA (ethylenediamine tetraacetic acid) injection.


Immunohistochemical study on alkaline phosphatase in the bovine intestine: a preliminary report.


The M. transversus thoracis in man and monkey.


Appetite suppression and central nervous system stimulation in the rhesus monkey.


Health aspects of the supply and use of non-human primates for biomedical purposes. Report of a WHO scientific group.


WHO Expert Committee on Biological Standardization. Twenty-third report.


Statistical indicators for the planning and evaluation of public health programmes. Fourteenth report of the WHO Expert Committee on Health Statistics.


Methods of fertility regulation: advances in research and clinical experience. Report of a WHO Scientific Group.


Studies on cerebral lipidosis. Enzymatic study of G M2 -gangliosidosis.


Studies on pulmonary arterial pressure curve in children with left to right intracardiac shunts.


Osseous sporotrichosis. Failure of treatment with potassium iodide and sulfadimethoxine and success with amphotericin B.


Detection of serum fibrinogen and fibrin degradation products. Comparison of six technics using purified products and application in clinical studies.


Active muscle vasodilation in primates homologous with sympathetic vasodilation in carnivores.


Mechanisms of drug resistance. The beta-lactamases of gram-negative bacteria including pseudomonads.


Training monkeys by LINC-8 computer.

Training monkeys by LINC-8 computer.


Pain reactivity of monkeys after lesions to the dorsal and lateral columns of the spinal cord.


Purification and properties of an arylsulfatase from Aspergillus oryzae.


Antischistosomal activity of a nitrovinylfuran derivative (SQ 18,506) in rhesus monkeys.


Membrane sialic acid and the mechanism of insulin action in adipose tissue cells. Effects of digestion with neuraminidase.


Effects on experimental animals of long-term inhalation exposure to carbon monoxide.


Pharmacokinetics of distribution and metabolism of ataractic drugs and an evaluation of the site of antianxiety activity.


The metabolism of certain drugs and food chemicals in man.


Salicylate metabolism in man.

Salicylate metabolism in man.


Bilirubin: a model for studies of drug metabolism in man.


Suxamethonium sensitivity.

Suxamethonium sensitivity.


Plasma protein binding, plasma concentrations, and effects of diphenylhydantoin in man.


The pharmacology of 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydro-homopyrimidazol-methylsulphate (MZ-144), a new, potent, non-narcotic analgesic. 3. Analysis of the central and peripheric effects.


The pharmacology of 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydro-homopyrimidazol-methylsulphate (MZ-144), a new, potent, non-narcotic analgesic. IV. The fate of MZ-144 within the organism.


Lysosomal enzyme levels in the blood of arthritic rats.


Studies on the functional significance of carbonic anhydrase in central nervous system.


Asymmetric audiogenic seizures in mice: a possible analogue of focal epilepsy.


Efferent cortico-cortical projections of the prefrontal cortex in the rhesus monkey.


A representation of the visual field in the caudal third of the middle tempral gyrus of the owl monkey (Aotus trivirgatus).


Antibodies to spermatozoa. 3. Responses in rabbits and guinea-pigs to immunization with guinea-pig sperm cells.


Immune complex cryoglobulinaemia in lepromatous leprosy: a pathogenetic approach to some clinical features of leprosy.


Comparative performance of epileptic and nonepileptic children and adolescents. (On tests of academic, communicative and social skills).


The Hiletron: new era in cancer treatment.


Impairment of cell-mediated immune responses by Pseudomonas aeruginosa.


Studies on short-lived internal  -emitters in mice and rats. I.  224 Ra.


Fate of preformed immune complexes in rabbits and rhesus monkeys.


Stapedial processes in tympanic cavities of capuchin monkeys (Cebus).


Occurrence of -globulin complexes in serum and joint fluid of rheumatoid arthritis patients: use of monoclonal rheumatoid factors as reagents for their demonstration.


C1g precipitins in the sera of patients with systemic lupus erythematosus and other hypocomplementemic states: characterization of high and low molecular weight types.


Hydergine effect on cerebral circulation in cerebrovascular disease.


Technique for unilateral isolation of the subdural space in the intact primate. Technical note.


Spinal arachnoid diverticula.

Spinal arachnoid diverticula.


Intracerebral fibroma in an 11-month-old infant. Case report.


Remarks on incomplete hypotheses for the control of cerebral circulation.


Preliminary observation on the hemodynamics of the internal carotid artery following bilateral external carotid ligation in the monkey.


K-shell fluorescence for the study of regional cerebral blood flow.


Bacteriological examinations of the pus from patients in the surgery wards of Dr. Soetomo Hospital, Surabaja, Indonesia.


Myoglobinemia after a single dose of succinylcholine.


Hypothalamic hypothyroidism.

Hypothalamic hypothyroidism.


Effects of anoxia on cerebrospinal fluid sodium and potassium concentrations.


Mastocytoma in a pig.

Mastocytoma in a pig.


EEG of rhesus monkeys following prolonged low-level feeding of pesticides.


Acute toxicity of aflatoxin B 1  in monkeys.


Ultrastructure of circulatory changes in the pars distalis of the hypophysis of hepatectomized mice.


Correlation between histological and biochemical parameters of isolated perfused rat liver.


The ultrastructure of the interfollicular epidermis of the hairless (hr/hr) mouse. I. Basal and granular layer.


Nuclear changes in glial cells after aluminum hydroxide.


Hyperglycemia, polyol accumulation, and increased intracranial pressure.


Experimental studies on the carbonic anhydrase activity. 13. Effect of aldosterone and actinomycin D in vivo on renal and hepatic carbonic anhydrase in mice.


Experimental studies on the carbonic anhydrase activity. XIV. Effect of aldosterone and actinomycin D in vitro on carbonic anhydrase from liver and kidney of mice.


Kinin-forming activity of human lymphocytes.


Topical treatment of psoriasis with triethylenethiophosphoramide (Thio-Tepa).


Present pattern of antibiotic sensitivity of gonococcal strains isolated in Bombay.


Absence of deconnexion syndrome in two patients with partial section of the neocommissures.


Polyester sponge swabs to facilitate examination for genital infection in women.


The transfer of human IgG subclasses from mother to foetus.


The quantitation of C6 in rabbit and human sera.


The activity of single trochlear nerve fibers during eye movements in the alert monkey.


The effect of hyperbaric oxygenation on retinal ischemia.


Lead poisoning in dogs.

Lead poisoning in dogs.


In vitro release of monkey pituitary growth hormone by acromegalic plasma.


Measurement of medroxyprogesterone acetate (Provera ) by radioimmunoassay.


Radioimmunoassay for triiodothyronine (T 3 ): I. Affinity and specificity of the antibody for T 3 .


Particulate and solubilized fucosyl transferases from mouse brain.


Regional changes in brain catecholamines after proton irradiation of the striate cortex in the squirrel monkey.


A primate model for the experimental production of Cushing's disease.


Distribution of tyrosine hydroxylase in human and animal brain.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 38-1971.


On the affinity of 3 different strains of bacteria, indigenous in infants' intestines, to the mucosal epithelial cells of the small intestines of white rat fetuses.


Transplantation of the primate uterus.

Transplantation of the primate uterus.


Atypical mycobacteria and uveitis.

Atypical mycobacteria and uveitis.


Resistance to aqueous outflow in the rhesus monkey eye.


Experimental retinal detachment in the owl monkey. 8. Photoreceptor protein renewal in early retinal reattachment.


Intrascleral smooth muscle in coloboma of the optic disk. Electron microscopic verification.


Rapid estimation of 241 Am content in plutonium.


Heart-rate change as a component of the orienting response in monkeys.


Stimulus generalization within the geniculostriate system of the monkey.


Family with hepatitis-associated antigen. Spectrum of liver pathology.


[The failure of nucleic acids to prevent the destruction of neurons in Chagas' disease].


Immunologic and immunotherapeutic studies with human sarcomas.


Distribution of systemic blood flow during total cardiopulmonary bypass in rhesus monkeys.


Determinants of implant flow through internal mammary artery.


Pseudomonas sepsis in gnotobiotic rats.

Pseudomonas sepsis in gnotobiotic rats.


Extended preservation of the primate liver by simple cooling and orthotopic auto transplantation.


Prevention of hepatic injury after jejuno-ileal bypass by supplemental jejunostomy feedings.


Maintenance of dogs without splanchnic portal organs.


Delayed hyperventilation in the treatment of experimental cerebral vascular occlusion.


Endotoxic shock in the baboon: some effects of glucocorticoid therapy.


Graded cryohypophysectomy in the rhesus monkey.


Mechanism and pathophysiology of experimentally induced cervicval spinal cord injuries in adult rhesus monkeys.


The ultrastructure of sheep pulmonary adenomatosis.


Light coagulation in presumed histoplasmic choroiditis. Controlled clinical study.


Ocular blood flow measurement by nuclide labeled microspheres.


Aerobic metabolism of  -amino-n-butyric acid by Pseudomonas putida.


Spontaneous perforation of bladder diverticula.


Gluconeogenic enzymes in sheep liver. Intracellular localization of pyruvate carboxylase and phosphoenolpyruvate carboxykinase in normal, fasted and diabetic sheep.


Automated immunochemical procedures for measurement of immunoglobulins IgG, IgA, and IgM in human serum.


Coulometric titration of blood glutathione.


Human secretory immunoglobulins. VI. Association of free secretory piece with serum IgA in vitro.


Immunoglobulins of normal human urine and urethral secretions.


Serum agglutinators in families with twins.


Physico-chemical properties of an agent that induces parthenogenesis in Rana pipiens eggs.


The effect of inoculum size on the immune response to BCG infection in mice.


Multiple forms of tyrosinase in rodents and lagomorphs with special reference to their genetic control in mice.


Dissociation of hemoglobin into subunits. Monomer formation and the influence of ligands.


Dissociation of hemoglobin into subunits. Ligand-linked dissociation at neutral pH.


Formymethionyl transfer ribonucleic acid transformylase: the specific interaction of the enzyme with its transfer ribonucleic acid substrate.


Cockayne's syndrome: case report.

Cockayne's syndrome: case report. The clinical features in a new non-familial case of Cockayne's syndrome comprised the usual components: dwarfism with microcephaly, severe mental subnormality, progeria-like appearance of the face, pigmented retinopathy, and severe perceptive deafness. The patient also suffered from grand mal epilepsy and died in status epilepticus at the age of 22 years. The neuropathological findings were severe microencephaly, widespread calcifying vasopathy with some secondary degenerative changes in the contiguous tissue, and granular ependymitis.


The syndrome of isolated epileptic status. Within a group of 23 patients who presented with status epilepticus a syndrome is defined in which sudden unheralded status occurs in apparently healthy individuals. Recovery from the attack is complete and no other evidence of cerebral pathology may be found at the time. In seven of nine such cases studied the final diagnosis at follow-up, either by necropsy or by operation, was of cerebral tumour. In five of the seven the fronto-temporal region was the site of pathology. It is suggested that the occurrence of isolated status indicates a possible cerebral tumour for which careful search should be made and, if negative, follow-up study arranged. Of 20 of our patients with status epilepticus in whom the site of lesion was definite, nine were exclusively frontal and a further six had some frontal involvement. This confirms previous evidence that symptomatic status epilepticus indicates a frontal lesion.


[Correlations of insulin stabilization quality and angiography in long-term insulin treated diabetics].


Ultrastructural study on cell-virus relationships in the thyroid of a salamander (Ambystoma macrodactylum Baird).


Adrenergic innervation of the oesophagus in the cat (Felis domestica) and Rhesus monkey (Macacus rhesus).


The anomalous temperature dependence of enzyme-catatlyzed reactions.


Bone disease in pet monkeys.

Bone disease in pet monkeys.


Panophthalmitis associated with diplococcic septicemia in a rhesus monkey.


The effect of the absence of rumen ciliate protozoa on growing lambs fed on a roughage-concentrate diet.


Indirect inguinal hernia in two rhesus monkeys.


Listeriosis associated with canine distemper in a gray fox.


Toxic enteritis in woolly monkeys.

Toxic enteritis in woolly monkeys.


What is your diagnosis?

What is your diagnosis?


An epizootic of brucellosis in mink.

An epizootic of brucellosis in mink.


Polypeptide chains from human red blood cell membranes.


Elasmobranch carbonic anhydrase. Purification and properties of the enzyme from two species of shark.


The role of RH antibodies in causing haemolytic disease of the newborn and in preventing it.


Clinical uses and control of rifampicin and clindamycin.


Liquor examination in the management of RH isoimmunization.


Thermal lysis of bacterial membranes and its prevention by polyamines.


Australia antigen and heaptitis: a review.


Alteration of fungal morphology induced by a substance from Bacillus cereus.


Mapping the  -aminolaevulinic acid synthetase locus in Bacillus subtilis.


Fatty acid nature and adjuvant activity of wax D from Mycobacterium tuberculosis.


Diaminopimelic acid and lysine auxotrophs of Pseudomonas aeruginosa 8602.