The localization of spectrin on the inner surface of human red blood cell membranes by ferritin-conjugated antibodies. Spectrin, a major protein constituent of mammalian red blood cell membrane preparations, has been localized on the inner surface of human red blood cell membranes by techniques that utilized specific ferritin-conjugated antibodies and fixation of membranes shortly after hemolysis so as to allow penetration of the ferritin-antibody labels. The labeling of spectrin was shown to be specific by the following criteria. (a) Nonhomologous ferritin-conjugated antibodies did not specifically bind to either membrane surface. (b) Blocking the membrane-bound spectrin with excess unconjugated antispectrin antibodies prevented ferritin-antibody labeling. (c) Removal of spectrin by treating the membrane preparation with a low ionic strength buffer containing ethylenediaminetetraacetate and beta-mercaptoethanol prevented labeling by specific ferritin-conjugated antibodies.


Photically evoked unit activity in the tectum opticum of the squirrel monkey.


Listeriosis in humans: an evaluation.

Listeriosis in humans: an evaluation.


Australia antigen immune complexes in patients with different forms of hepatitis.


Development and persistence of antibody to hepatitis-associated (Australia) antigen in patients with hemophilia.


Human listeriosis in the United States, 1967-1969.


Erythrocyte velocity and fluorescein transit time in the cerebral microcirculation of macroglobulinemic mice: differential effect of a hyperviscosity syndrome on the passage of erythrocytes and plasma.


The mode of development of urinary infection in intermittently catheterised male paraplegics.


Familial pubic bone maldevelopment.

Familial pubic bone maldevelopment.


Vesicoureteral reflux causing improved visualization on the delayed excretory urogram.


Operant conditioning of specific patterns of neural and muscular activity. In awake monkeys we recorded activity of single "motor" cortex cells, four contralateral arm muscles, and elbow position, while operantly reinforcing several patterns of motor activity. With the monkey's arm held semiprone in a cast hinged at the elbow, we reinforced active elbow movements and tested cell responses to passive elbow movements. With the cast immobilized we reinforced isometric contraction of each of the four muscles in isolation, and bursts of cortical cell activity with and without simultaneous suppression of muscle activity. Correlations between a precentral cell and specific arm muscles consistently appeared under several behavioral conditions, but could be dissociated by reinforcing cell activity and muscle suppression.


Recent advances in the use of prosthetics in neonatal surgery.


Pulmonary changes in treated and untreated hemorrhagic shock. I. Early functional and ultrastructural alterations after moderate shock.


Current management of corrosive esophagitis.


Changes in the fluorescence patterns of translocated Y chromosome segments in Drosophila melanogaster.


Lithium and rubidium: a role in the affective disorders.


Long-term administration of Doxepin (Sinequan). (Clinical and laboratory survey of 40 patients).


Synthesis of neomycin by washed mycelium of Streptomyces fradiae and some physiological considerations.


Genetic heterogeneity among the founders of laboratory populations of Drosophila. IV. Scutellar chaetae in different environments.


Meiosis. 8. Segregation matrix methods applied to meioic drive in Drosophila melanogaster males with an SC 4 -SC 8 inverted X.


Recombination in the X chromosome of Drosophila melanogaster females heterzygous for two autosomal translocations.


Rabbit platelet bactericidal protein.

Rabbit platelet bactericidal protein. The heat-stable antibacterial activity of rabbit serum against Gram-positive microorganisms has been shown to reside in a cationic protein fraction of platelet lysosomal granules. The activity is released during platelet aggregation. No plasma or serum component is required for the bactericidal effect. The platelet bactericidin resembles the antibacterial proteins of leukocyte granules both in cellular localization and in biochemical characteristics. It can be differentiated from platelet factor 4, the antiheparin factor, which is also a basic protein in platelet granules. The antibacterial effect of the platelet bactericidin may be related to the metabolic activity of the organisms. This antibacterial activity of platelets may represent another means by which platelets can participate in host inflammatory defense reactions.


Iron absorption in hemochromatosis before and after phlebotomy therapy.


Cerebrospinal fluid scanning with  111 In.


The problem of the frontal lobe: a reinterpretation.


Connections of the parietal lobe.

Connections of the parietal lobe.


Idea of a new anatomy of the thalamus.

Idea of a new anatomy of the thalamus.


Specificity of responses of cells in the visual cortex.


Emotion revisited.

Emotion revisited.


Aggressive behavior of chimpanzees and baboons in natural habitats.


Effect of host cell on distribution of a lysosomal enzyme during virus infection. The time of appearance of a lysosomal enzyme, beta-glucuronidase, in the medium of cells infected with either measles virus or echovirus 6 varied with the host cell system. Replication and release of virus preceded leakage of beta-glucuronidase from green monkey kidney cells. In contrast, extracellular enzyme appeared before replication and release of virus in human amnion cells. Hydrocortisone depressed enzyme leakage but did not retard replication of measles virus or viral-induced cytopathology. The intracellular distribution of beta-glucuronidase in uninfected and measles virus-infected cells was also studied. Measles virus infection altered the position of particulate-bound beta-glucuronidase in linear sucrose gradients prior to substantial release of this enzyme intra- and extracellularly. At early stages in infection, most of the cell-associated virus banded with particulate-bound enzyme in the middle of the gradient. As infection progressed, separation of measles virus infectivity from enzyme activity occurred, and intracellular virus was recovered near the meniscus of sucrose gradients.


Abortive infection of sporulating Bacillus subtilis 168 by phi 2 bacteriophage. Bacteriophage phi2 is unable to replicate in Bacillus subtilis 168. Although some phage deoxyribonucleic acid (DNA) synthesis can occur, the DNA made is not biologically active and sedimentation analysis reveals that it is smaller in size than that of mature DNA or DNA isolated from phi2-infected permissive hosts. Messenger ribonucleic acid hybridizable with phi2 DNA is also synthesized in phi2-infected cells of 168. Mutants of 168 which are permissive hosts for phi2 have been isolated. These mutants are defective in sporulation and possess the phenotype of "early sporulation mutants." The majority map in two locations, one near the lys locus opposite the trp locus (spoA locus) and the other tightly linked to a phe locus.


Effect of fenfluramine on the electrical activity of the hypothalamic feeding centers.


The incidence of Haemoproteid parasites in New Guinea bats.


Malaysian primate trypanosomes: intra-cytoplasmic pigment.


Lysogeny of a blue-green alga, Plectonema boryanum.


The use of oblique illumination in microscopic observations of living protozoa.


Replication of tobacco mosaic virus. I. Isolation and characterization of double-stranded forms of ribonucleic acid.


The assembly of RNA-free mixed-coat capsids of small spherical viruses.


The potentiation of type 1 adeno-associated virus by temperature-sensitive conditional-lethal mutants of CELO virus at the restrictive temperature.


Prenatal antibody screening and use of Rho(D) immune globulin (human).


Preparation and some properties of the nucleic acid of tobacco streak virus.


On the identity of two simian hemorrhagic fever virus strains (Sukhumi and NIH).


An electron microscopic study of the permeability of iris capillaries to horseradish peroxidase in the vervet monkey (Cercopithecus aethiops).


The production and effectivity of rabbit antiserum against Vespa orientalis venom.


Evaluation of disodium cromoglycate in asthmatic children.


Prophylactic antibiotics in asthmatic children.


Tobacco sensitivity in the allergic patient.


Food allergy, anaphylactic shock and neurological symptoms.


Protective effect of disodium cromoglycate on the allergen provocation of the nasal mucosa.


Prolongation of rabbit xenograft survival with antimacrophage serum in rats.


Studies in ageing. 8. Hormonal concentration and homeostatic adjustment in Drosophila.


Cell size and cell number in the wing of Drosophila melanogaster as related to parental ageing.


Influence of phenacon on the mono- and polysynaptic spinal reflexes.


The mastocyte reaction in pterygium.

The mastocyte reaction in pterygium.


A false myasthenic-like early depression in the electromyogram of M. tibialis anterior by repetitive supramaximal electrical stimulation of the supplying nerve.


[Work expert evaluation of roentgenomorphological changes in pneumoconioses].


Arteriovenous fistule of the liver in liver cirrhosis with carcinoma.


The effect of osmotic flow on the distribution of horseradish peroxidase within the intercellular spaces of toad bladder epithelium.


Studies on epithelial cells isolated from guinea pig small intestine. Sheets of mucosal epithelial cells were released from guinea pig small intestine after incubation with ethylenediaminetetraacetate. Cells in sheets retained their columnar shape for 24 hr at room temperature, and exclusion of nigrosine suggested they had intact plasma membranes. When sheets were disaggregated individual cells had normal morphology for at least 4 hr. During isolation 16% of the total protein and 24% of the total lactic dehydrogenase were lost from the cells, but subsequent enzyme leakage was low. Leakage increased with shaking, incubation at 37 degrees C, or increasing the oxygen tension of the suspending medium, but was minimal when the Na(+):K(+) ratio in the medium was 8:1 and the osmolarity was high. Losses of particulate enzyme activities were negligible. Respiration was constant for up to 4 hr and was insensitive to calcium, bicarbonate, oxygen tension, and pH. It was inhibited by cyanide and iodoacetate and varied with the Na(+):K(+) ratio of the extracellular fluid and the structural integrity of the cells. All preparations concentrated potassium and excluded sodium, but lost this ability if ouabain was added or cells were broken. Potassium-42 uptake was also sensitive to temperature, ouabain, and structural integrity. The preparations are being used to study cell metabolism in the intestinal epithelium.


L-asparaginase and complement.

L-asparaginase and complement.


Experiences with children and their families during extended hemodialysis and kidney transplantation.


Outer mitochondrial membrane continuous with endoplasmic reticulum.


Drinking and the social behavior of rhesus monkeys.


The Australia-SH antigen: detection methods and clinicl significance.


Ionic dependence of the third phase of the light-evoked response from amphibian pigment epithelium cells.


Pseudarthrosis of the lateral malleolus.


Boric acid--a useful preservative for urine samples.


In vivo properties of attenuated rubella virus, "Cendehill" strain.


A simple plaque assay for influenza A 2  viruses and its application to antiviral screening.


The topographical distribution of interhemispheric projections in the corpus callosum of the rhesus monkey.


Epileptiform activity evoked by intracerebral injection of anti-brain antibodies.


The aetiology of bacterial meningitis in Karamoja.


The coat protein gene of tobacco mosaic virus. I. Location of the gene by mixed infection.


On the arrangement of genes for 28 s and 18 s ribosomal RNA's in Drosophila melanogaster.


Significance of the free 70 s ribosomes in Escherichia coli extracts.


Translation and polarity in the histidine operon. IV. Relation of polarity to map position in hisC.


Messenger RNA in rat liver polyribosomes: evidence that it exists as ribonucleoprotein particles.


The influence of zinc gluconate and casein hydrolysate on the fluid and tissue kinetics of zinc-65 in the baboon prostate.


The effects of uremia on erythropoietin activity.


Sequential liver scanning.

Sequential liver scanning.


The effect of depostat (SH 582) on the baboon prostate.


Histopathological changes in autotransplanted baboon kidneys after 24-hour hyperbaric, hypothermic preservation perfusion.


Use of a whole-body counter in bone scanning.


Simultaneous bilateral radical neck dissection following high-level radiation therapy.


Ultrastructural alterations of Trypanosoma cruzi kinetoplast induced by the interaction of a trypanocidal drug (hydroxystilbamidine) with the kinetoplast DNA.


A study of the oxidation-reduction state of synthetic 3,4-dihydroxy-DL-phenylalanine melanin.


Investigations on aerobic oral and nasal flora of university students.


Nosematosis as an accompanying infection of plasmacytoma ascites in Syrian golden hamsters.


Study of oral, nasal and skin flora in an investigation on hospital infection.


Subacute sclerosing panencephalitis, measles, rabies and progressive multifocal leukoencephalopathy.


Transmission and characterization of the agents of spongiform virus encephalopathies: kuru, Creutzfeldt-Jakob disease, scrapie and mink encephalopathy.


The sigma factors of RNA polymerase.

The sigma factors of RNA polymerase.


Xenogeneic storage of primate hearts.

Xenogeneic storage of primate hearts.


Basement membrane antigens in serum and urine.


Streptococcal-related glomerulonephritis in the Rhesus monkey.


Molecular-genetic approaches to the classification of animals.


Role of streptococcal and other heterologous antigens in transplantation.


Experimental islet cell grafting: a transplantation model.


Radiation chimeras.

Radiation chimeras.


Comparative physiologic studies in primates.


The Cape Western baboon in organ allotransplantation.


Organ transplantation between widely disparate species.


Human origins: an immunological view.

Human origins: an immunological view.


Labyrinthine and extra-labyrinthine effects on ocular counter-rolling.


Middle ear epithelium in the presence of experimental effusion.


Direct beam control in radiotherapy with high energy photons.


Red and white muscle.

Red and white muscle.


Diagnostic mycoserology by immunoelectroosmophoresis: a general, rapid, and sensitive microtechnic.


Variation of specificity of autoantibodies in autoimmune hemolytic anemia.


Carbenicillin-induced alterations in the surface morphology of bacteria: a scanning-beam electron microscope study.


Antimicrobial studies in vitro with CIBA 36278-Ba, a new cephalosporin derivative.


BL-P 1654, a new broad-spectrum penicillin with marked antipseudomonal activity.


Inhibition of meningococci by new antimicrobial agents in vitro and recognition of a class of sulfones with a unique mechanism of antibacterial activity.


Relationship of colonization with Pseudomonas aeruginosa to development of Pseudomonas bacteremia in cancer patients.


In vitro evaluation of nifuratrone.

In vitro evaluation of nifuratrone.


Relationship of Pseudomonas aeruginosa immunotypes to antibiotic susceptibility patterns.


Streptococcal pharyngitis therapy: comparison of cyclacillin, cephalexin, and potassium penicillin V.


Penicillin-resistant oral streptococci.

Penicillin-resistant oral streptococci.


Surveillance of Pseudomonas aeruginosa infections in a Children's hospital.


In vitro studies of a semisynthetic penicillin, 6-(D(-)- -carboxy-3-thienylacetamido) penicillanic acid (BRL 2288), active against Pseudomonas.


-carboxy-3-thienylmethylpenicillin (BRL 2288), a new semisynthetic penicillin: in vitro evaluation.


-carboxy-3-thienylmethylpenicillin (BRL 2288), a new semisynthetic penicillin: in vivo evaluation.


-amino-p-hydroxybenzylpenicillin (BRL 2333), a new semisynthetic penicillin: in vitro evaluation.


-amino-p-hydroxybenzylpenicillin (BRL 2333), a new broad-spectrum semisynthetic penicillin: in vivo evaluation.


Application of four methods to the study of the susceptibility of yeast to 5-fluorocytosine.


Enterococcal resistance to antibiotic synergism.


Susceptibility of Proteus species and Pseudomonas aeruginosa to penicillins and cephalosporins.


In vitro susceptibility of meningococci to antimicrobial agents.


Rapid microassay for circulating nephrotoxic antibiotics.


Autolysis of Bacillus cereus cell walls and isolation of structural components. Autolysis of Bacillus cereus N.R.R.L. 569 cell walls was accompanied by hydrolysis of the majority of the 4-O-beta-N-acetylglucosaminyl-N-acetylmuramic acid linkages in mucopeptide, presumably by an endo-beta-N-acetylglucosaminidase. Hydrolysis of the N-acetylmuramyl-l-alanine linkages by an amidase also occurred. Free d-alanine residues were detected in isolated cell walls and the proportion of these residues increased during autolysis, presumably due to d-alanine carboxypeptidase action. Fractionation and analysis of the products of autolysis confirmed these results. Among the products originating from mucopeptide were a disaccharide, N-acetylmuramyl-N-acetylglucosamine, and a tetrapeptide of sequence l-Ala-d-Glu-meso-Dap-d-Ala (Dap=diaminopimelate). A dimer fraction containing a d-Ala-meso-Dap cross-link was also isolated. Two polysaccharides were obtained from the products of autolysed cell walls and from walls made soluble by Chalaropsis B glycosidase. A neutral polysaccharide accounted for about 40% of the wall and contained N-acetylglucosamine, N-acetylgalactosamine and glucose. The neutral polysaccharide isolated from wall autolysates was attached to a part of the glycan moiety of mucopeptide. The molecular weight of the complex was approx. 28000. Stoicheiometric amounts of phosphorus were present, possibly in linkages between the polysaccharide and mucopeptide moieties. The second polysaccharide accounted for 12% of the wall and was very acidic. After acidic hydrolysis of the polysaccharide, glucosamine, galactosamine and unidentified acidic substances were detected. The acid polysaccharide isolated from wall autolysates contained only traces of mucopeptide constituents and no phosphorus.


Phospholipids of Listeria monocytogenes.


Egg proteins in cod serum. Natural occurrence and induction by injections of oestradiol 3-benzoate. 1. Before the uptake of water that precedes spawning, eggs of cod (Gadus morhua L.) contained 30% dry matter, of which 80% was protein. Some 75% of this protein was soluble in 0.5m-sodium chloride. The major components in the extract were two similar lipoproteins, of molecular weight about 400000, containing 21% lipid, some two-thirds of which was phospholipid, and about 0.5% protein phosphorus. 2. These lipoproteins were identified by immunochemical methods in the serum of female cod with developing ovaries, but not in the serum of male or of immature female fish. 3. The concentrations of egg proteins in the serum of female cod were determined by a serial-dilution double-diffusion immunological method, and were shown to increase with development of the ovaries, reaching a value of about 32mg/ml when the weight of the ovaries was 10% of the weight of the fish. 4. Immature male and female cod were injected intramuscularly with a solution of oestradiol-17beta 3-benzoate in oil and the concentration of egg proteins in their serum was measured by the immunodiffusion method. The serum contained no detectable egg proteins before injection of the fish, but 30mug of oestradiol benzoate/kg gave rise to detectable amounts of egg proteins in 10 days, and with 300mug or 1mg of oestradiol benzoate/kg the concentration of egg proteins rose to 32mg/ml. The values for male and female cod were similar and represented about one-half of the total serum protein. 5. With a dose of 1mg of oestradiol benzoate/kg, egg proteins were first detected in the serum 2 days after injection and the concentration increased up to 10 days. 6. Serum samples taken before and 10 days after an injection of 1mg of oestradiol benzoate/kg were fractionated by gel-filtration on Sephadex G-200. The difference curves obtained from fractionation curves after and before injection confirmed the values of the concentrations of egg proteins obtained from the immunodiffusion test and showed that the concentrations of the normal serum components fell by 20-50% of the initial value, the high-molecular-weight globulins showing the most marked fall. 7. Egg proteins were detected in the liver and testes of the injected fish, but not in the ovaries.


Osteogenic sarcoma of the breast.

Osteogenic sarcoma of the breast.


Action of lecithin-cholesterol acyltransferase on sonicated dispersions of lecithin and cholesterol and on lecithin-cholesterol-protein complexes.


Ecological adaptation and mammalian reproduction.


Convergent input from the striate cortex (area 17) to the cortex of the superior temporal sulcus in the rhesus monkey.


Transport and binding of galactose by Streptococcus faecalis.


The accumulation of phenolic acids and coproporphyrin by iron-deficient cultures of Bacillus subtilis.


Antibody production in goat milk serum after virus instillation of goat mammary gland. V. Biochemical isolation and further characterization of antibodies to various influenza and mumps viruses.


Genetic evidence for heterozygotes in mixed culture of Bacillus cereus.


Metabolic activity of acetate-grown Bacillus megaterium KM.


Selective inhibition of certain enteric bacteria by selenite media incubated at 35 and 43 C.


Alkaline phosphatase localization and spheroplast formation of Pseudomonas aeruginosa.


Avian Lankesterella infections in Algonquin park, Ontario.


The mechanism of iron uptake in Bacillus subtilis.


Clindamycin in the treatment of soft tissue infections.


Determination of tranquillizers by GLC in biological fluids.


Effectiveness of erythromycin plus alkalinization and of nitrofurantoin in the treatment of urinary tract infections.


Respirophonographical measurements into the effect of bromhexine in the treatment of chronic bronchitis.


Further experience with "minidosage" in fibrinolytic treatment.


Haloperidol as a treatment of anxiety in psychoneurotic patients.


A clinical trial of SCH-12041 with chronic alcoholic patients.


Treatment of emotional symptoms and insomnia with plexonal.


GP-45795: A new dibenzothiepin antipsychotic agent.


Automatic ultrasonic blood pressure measurement in children: a feasibility study.


Accuracy of an ultrasound blood pressure instrument in neonates, infants, and children.


Respiratory effects of diviminol, a new analgesic.


Active transport of iron in Bacillus megaterium: role of secondary hydroxamic acids. Kinetics of radioactive iron transport were examined in three strains of Bacillus megaterium. In strain ATCC 19213, which secretes the ferric-chelating secondary hydroxamic acid schizokinen, (59)Fe(3+) uptake from (59)FeCl(3) or the ferric hydroxamate Desferal-(59)Fe(3+) was rapid and reached saturation within 3 min. In strain SK11, which does not secrete schizokinen, transport from (59)FeCl(3) was markedly reduced; the two ferric hydroxamates Desferal-(59)Fe(3+) or schizokinen-(59)Fe(3+) increased both total (59)Fe(3+) uptake and the (59)Fe(3+) appearing in a cellular trichloroacetic acid-insoluble fraction, although 10 min was required to reach saturation. Certain characteristics of transport from both ferric hydroxamates and FeCl(3) suggest that iron uptake was an active process. The growth-inhibitory effect of aluminum on strain SK11 was probably due to the formation of nonutilizable iron-aluminum complexes which blocked uptake from (59)FeCl(3). Desferal or schizokinen prevented this blockage. A strain (ARD-1) resistant to the ferric hydroxamate antibiotic A22765 was isolated from strain SK11. Strain ARD-1 failed to grow with Desferal-Fe(3+) as an iron source, and it was unable to incorporate (59)Fe(3+) from this source. Growth and iron uptake in strain ARD-1 were similar to strain SK11 with schizokinen-Fe(3+) or the iron salt as sources. It is suggested that the ferric hydroxamates, or the iron they chelate, may be transported by a special system which might be selective for certain ferric hydroxamates. Strain ARD-1 may be unable to recognize both the antibiotic A22765 and the structurally similar chelate Desferal-Fe(3+), while retaining its capacity to utilize schizokinen-Fe(3+).


Wax D from different bovine strains of Mycobacterium. Wax D(P), a peptido-glycolipid found in extracts of Mycobacterium tuberculosis var. hominis, was not found in extracts of three strains of still-grown M. tuberculosis var. bovis (BCG, Marmorek and Dupray). However, extracts from three other bovine strains (Behring, LA and BB) did yield waxes D(P), and these did not differ as to their molar ratios of alanine/glutamic acid/diaminopimelic acid from human waxes D(P).


Bactericidal action of 2-hydroxy-3-(cyclohexylpropyl)-1,4-naphthoquinone on Bacillus megaterium. The antimalarial drug, 2-hydroxy-3-(cyclohexylpropyl)-1,4-naphthoquinone (NQ), at concentrations of approximately 10(-5)m (3 mug/ml), was bactericidal for the gram-positive bacterium, Bacillus megaterium. Only a few other gram-positive bacteria were sensitive to this drug. All growth inhibitory concentrations of NQ were also bactericidal for B. megaterium, and even resting suspensions of cells were killed. The incorporation of radioactive-labeled leucine, thymidine, uracil, and diaminopimelic acid into protein, deoxyribonucleic acid, ribonucleic acid, and the cell wall polymer was arrested immediately and completely upon addition of NQ to cultures in exponential growth. NQ produced a delayed effect on aerobic respiration and no change in the rate of oxygen consumption was observed at a time when all major biosyntheses had failed. (3)H-NQ was demonstrated to bind strongly and preferentially to the bacterial cell membrane. This simultaneous shutdown of all major categories of in vivo macromolecular syntheses points to an effect of NQ upon membrane-centered energy supplying reactions or transport of essential nutrients, or both.


Complementary functioning of nitrogenase components from a blue-green alga and a photosynthetic bacterium. Nitrogenases from Anabaena cylindrica and Chloropseudomonas ethylicum were partially purified into two components. A. cylindrica fraction I protein complemented fraction II protein from C. ethylicum. However, the reciprocal cross between C. ethylicum fraction I and A. cylindrica fraction II was negative.


Observations on replication and cell division in synchronous cultures of the blue-green alga Anacystis nidulans. A second synchrony induction treatment, half-way through the deoxyribonucleic acid replication process of an already synchronized culture, resulted in defective subsequent cell growth. This supports a previous explanation for the partial loss of viability after synchrony induction.


Folate replacement by tetrahydrohomopteroate in triazine-resistant bacteria. Tetrahydrohomopteroate, which inhibits the growth of Streptococcus faecium (Streptococcus faecalis ATCC 8043), replaces folate as a growth factor in chlorguanide triazine-resistant strains of this organism.


Phonocardiographic studies during experimental hypo- and hypervolemia in the healthy newborn.


Ribonucleic acid synthesis in bacteria treated with toluene. Escherichia coli and Bacillus megaterium rendered permeable to ribonucleoside triphosphates by toluene treatment retain the capacity to synthesize discrete ribonucleic acid species.


Analysis of prognostic factors in patients with primary breast carcinoma.


Conformational analysis of DNA-poly-L-lysine complexes by optical rotatory dispersion.


Messenger RNA-protein complexes and newly synthesized ribosomal subunits: analysis of free particles and components of polyribosomes.


A new phage of Bacillus subtilis with infectious DNA having separable strands.


First of all do no harm.

First of all do no harm.


Fungal septicemia in patients receiving parenteral hyperalimentation.


Chagasic myocardiopathy.

Chagasic myocardiopathy.


Synthetic thyrotropin-releasing hormone. A potent stimulator of thyrotropin secretion in man.


Listeria monocytogenes meningitis during immunosuppression.


Molecular evolution in the descent of man.


Hypothalamic control of food intake.

Hypothalamic control of food intake.


The effect of environmental temperature on the metabolism and nutrition of burned patients.


Post-operative parenteral nutrition.

Post-operative parenteral nutrition.


Feeding the unconscious patient.

Feeding the unconscious patient.


Membrane potentials in Stentor coeruleus.


Rhesus lymphocyte alloantigens. I. Identification of a major alloantigen system.


LSD: induction of mosaic mutations in the spermatozoa of Drosophila melanogaster.


Different reaction of focal and diffuse epileptic EEG activity to psilocybin.


Cerebral ATP and lactate levels in the squirrel monkey following occlusion of the middle cerebral artery.


An attempt to detect drug abuse.

An attempt to detect drug abuse.


Clinical experience with determination of fibrinogen degradation products.


Impetigo contagiosa.

Impetigo contagiosa.


Differential reactivity of the myoendometrial and placental vasculatures: vasodilatation.


Effects of betahistine HCl, nicotinic acid, and histamine on basilar blood flow in anesthetized dogs.


Uranyl salts as fixatives for electron microscopy. Study of the membrane ultrastructure and phospholipid loss in bacilli.


The effect of dimethylsulphoxide on the permeability of the lysosomal membrane.


Interaction of lymphocytes and phytohaemagglutinin: inhibition by chelating agents.


Cytoplasmic pools of guanine derivatives in euglena?


Properties of microtubule proteins in different organelles in Tetrahymena pyriformis.


Synthesis and assembly of microtubule proteins in Tetrahymena pyriformis.


Changes in the properties of cell-substrate adhesion during cultivation of chicken fibroblasts in vitro in a serum-free medium.


Synchrony in Tetrahymena by heat shocks spaced a normal cell generation apart.


The role of two retina antigens in production of experimental allergic uveitis and its suppression by mycobacteria.


The cardiac auto-immune system. IV. Rat anti-rat heart auto antibodies, and plasma protein allotypic differences between two colonies of Sprague-Dawley rats.


In vitro diagnosis of atopic allergy. IV. Seasonal variations of IgE antibodies in children allergic to pollens.


An antigenic relationship between kidney and certain Escherichia coli strains.


The effect of total nephrectomy on hematopoiesis in patients undergoing chronic hemodialysis.


Atomic absorption determination of lead in blood and urine in the presence of EDTA.


Potential folic acid antagonists. 5. Synthesis and biologic evaluation of N 10 -deazapteroic acid and N 10 -deazafolic acid and their 9,10-dehydro derivatives.


Relationship of firing patterns of units in face area of monkey precentral cortex to conditioned jaw movements.


Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey. II. Response to sinusoidal stimulation and dynamics of peripheral vestibular system.


Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey. I. Resting discharge and response to constant angular accelerations.


Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey. 3. Variations among units in their discharge properties.


Some effects of stimulus intensity on response of auditory nerve fibers in the squirrel monkey.


Cricopharyngeal myotomy in dysphagia.

Cricopharyngeal myotomy in dysphagia.


Intranasal intal (disodium cromoglycate).


Hypoprothrombinaemia in patients undergoing prolonged intensive care.


Surgical applications of hyperbaric oxygen therapy in the Royal Navy.


Spike-wave paroxysms and information processing.


Tracheal lesions following tracheostomy.


Fibrinolysis in animals.

Fibrinolysis in animals.


Causes and prevention of sepsis due to gram-negative bacteria. Ecology of the infecting organisms.


Causes and prevention of sepsis due to Gram-negative bacteria. Common-source outbreaks.


Control of infection with gram-negative bacteria in patients at special risk.


Bowel colonization of hospital patients by Pseudomonas aeruginosa and Escherichia coli.


The fine structure of ultimobranchial secretory cells in the anurans: Rana temporaria L. and Bufo bufo L.


The effects of methoxamine and ephedrine in normotensive pregnant primates.


Lentiginosis profusa syndrome (multiple lentigines syndrome).


Six cases of gall-bladder adenomyomatosis (cholecystitis glandularis proliferans).


Decreased calcium uptake by rat fundal strips after pretreatment with neuraminidase or LSD in vitro. Effect of serotonin, D-amphetamine and eledoisin on the uptake.


Effect of 1,10-phenantroline and EDTA on bradykinin assay on the guinea-pig ileum.


Aflatoxin B induced inhibition of liver protein synthesis in vivo and its role in fatty liver.


Chemical modification of the fluorescent base in phenylalanine transfer ribonucleic acid.


Urinary estrogen excretion in pregnant rhesus monkeys.


Effect of incubating chicken semen in the hen's oviduct on sperm enzyme activities, semen pH, motility, and fertility.


A fluorescence staining method for studying sperm membranes.


Chemical studies on the exudate and developing sclerotia of Sclerotinia sclerotiorum (Lib.) DeBary.


Isolation and preliminary characterization of an extracellular protease of Cytophaga sp.


Immunological relationships between capsid components of adenoviruses of different host cell species origin.


The assessment of whole-body dose, using personal dosemeters.


Thorotrast quantities and whole-body counts.


A new human allotype carried by the  G3 subclass: Gm(25).


Thoracic force-deflection studies in primates.


A comparison of the elasticity of live, dead, and fixed brain tissue.


Mechanical properties on cranial bone.

Mechanical properties on cranial bone.


Thoracic force-deflection studies in living and embalmed primates.


Studies on the sterility phenotype of the pleiotropic mutant fused of Drosophila melanogaster.


Bilateral posterior fracture-dislocation of the shoulder and other trauma caused by convulsive seizures.


Anterior displacement of the mandible in adult rhesus monkeys: long-term observations.


Heterotopic ossification and the surgical treatment of serious contractures.


Screening for urinary tract infection.

Screening for urinary tract infection.


Pneumocystis carinii pneumonia.

Pneumocystis carinii pneumonia.


Isolated fractures of the posterior tibial lip at the ankle as demonstrated by an additional projection, the "poor" lateral view.


Cerebral angiographic changes in the drug abuse patient.


IgA: presence in meconium obtained from patients with cystic fibrosis.


Spondylometaphyseal dysplasia (Kozlowski). Report of affected mother and son.


Cerebral vascular changes secondary to amphetamine abuse in the experimental animal.


Effect of dimethyl sulfoxide on experimental cytosiderosis.


Degradation of DNA by cysteine.

Degradation of DNA by cysteine.


Argininosuccinase from bovine kidney: comparison of catalytic, physical, and chemical properties with the enzyme from bovine liver.


Modification of the active site of isocitrate lyase from Pseudomonas indigofera.


On the active site of diamine oxidase: kinetic studies.


The purification and properties of aspartase from Escherichia coli.


A testicular isoenzyme of carbonic anhydrase.


Interaction of transferase II with polynucleotides and inhibition of the interaction by guanosine nucleotides.


Synthesis of aldehydes and their interactions during the in vitro aging of collagen.


DNA content of mastocytoma cells in cell culture after inhibition of RNA synthesis with 6-azauridine.


Report of Inter-Society Commission for Heart Disease Resources. III. Cardiovascular Disease--long-term care. Guidelines for the detection, diagnosis and management of hypertensive populations.


The use of cyclandelate in chronic brain syndrome with arteriosclerosis.


Comparative virology of primates.

Comparative virology of primates.


A technique in the evaluation of psychotropic medication based on a patient demand schedule: comparison of the efficacy of oxypertine, diazepam and placebo in anxiety.


When is a tranquillizer an antidepressant?


Doxepin in the treatment of psychoneurotic inpatients.


Evaluation of the antipsychotic activity of an indole analogue, AL-1612.


Absorption of "slow Fe" measured with a total body counter.


Clinical evaluation of tralonide ointment, a new topical steroid.


Quantitative polygraphic evaluation of emotional tension in the study of a new benzodiazepine.


Statistical summary of 10,000 male cases using Afrodex in treatment of impotence.


Juxta-ampullar duodenal diverticula as cause of bilio-pancreatic disease.


Intal in asthma and hay fever.

Intal in asthma and hay fever.


The Scottish Hospital Advisory Service. The first year.


Media for selective isolation of mycobacteria.


Efficacy of mycobacterial cell walls as a vaccine against airborne tuberculosis in the Rheusus monkey.


Serum antibody response in renal versus bladder bacteriuria.


Currents in tuberculosis research.

Currents in tuberculosis research.


Biosynthesis of coenzymes Q by malarial parasites. 2. Coenzyme Q synthesis in blood cultures of monkeys infected with malarial parasites (Plasmodium falciparum and P. knowlesi).


Schistosomicides. 1. Derivatives of 2-aminomethyl-1,2,3,4-tetrahydroquinoline.


Interaction of ergothioneine with metal ions and metalloenzymes.


Gentamicin antibiotics. 4. Some condensation products of gentamicin C2 with aromatic and aliphatic aldehydes.


Industry's role in the delivery of health care.


The pre-employment examination--worth its cost?


Collaborative study of aerobic media for sterility testing by membrane filtration.


Disseminated intravascular coagulation and renal failure: Production in the monkey with autologous red blood cell stroma.


Production of arterial hemosiderosis in rhesus monkeys following the ingestion of  -aminopropionitrile.


Protein-induced bleeding.

Protein-induced bleeding.


Early blocked asporogenous mutants of Bacillus subtilis 168. I. Isolation and characterization of mutants resistant to antibiotic(s) produced by sporulating Bacillus subtilis 168.


Oxygen tension, acid-base status and electrolytes in human amniotic fluid.


Fatal infections in childhood leukemia.

Fatal infections in childhood leukemia.


Incontinentia pigmenti (Bloch-Sulzberger syndrome). A report of four additional cases.


Acute appendicitis with perforation.

Acute appendicitis with perforation.


Effect of feeding selenium-deficient ration to the subhuman primate (Saimiri sciureus).


Avian brucellosis: a case report of natural transmission from cattle.


The decerebrate state in the primate. I. Studies in monkeys.


Infantile spasms and hypopigmented macules. Early manifestations of tuberous sclerosis.


Dodecylamine in the isolation of bacterial DNA.


Nephrotic syndrome in monkey infected with human quartan malaria. A splenectomized aotus monkey infected with human quartan malaria (Plasmodium malariae) developed oedema and proteinuria. Histological examination revealed a generalized diffuse glomerulonephritis and immunofluorescent staining showed granular deposits of IgM in the glomeruli. The pathological picture resembled that shown by human patients with the quartan malaria nephrotic syndrome.


A physiological basis for "hysterical" analgesia.


Use of sheep insulin in insulin allergy.


Intravascular sickling associated with diabetic ketoacidosis.


An automated complement fixation procedure for detecting antibody to N. gonorrhoeae.


Prenatal immunization of the lamb to brucella; secondary antibody response in utero and at birth.


The isolation of ox red cell membrane antigens: antigens associated with sialoprotein.


The primary structure of the beta-polypeptide chain of adult hemoglobin of the Japanese monkey (Macaca fuscata fuscata).


The antimicrobial activity of human colostral antibody in the newborn.


Correlated studies of a recombinant influenza-virus vaccine. 3. Protection against experimental influenza in man.


Quantitation of hepatitis-associated antigen with a modified Ouchterlony precipitin test.


Transmission of human hepatitis to marmosets: further coded studies.


Novel schistosomicides. S-2-((2-(2-thiazolylcarbamoyl)ethyl)amino)ethyl hydrogen thiosulfate and related compounds.


Neuropharmacological profile of 1-azaphenothiazine-10-thiolcarboxylates.


Antibacterial nitrofuran derivatives. 4. 5-Nitro-2-furaldehyde hydrazoniumacethydrazones.


Prophylactic use of antibacterial drugs following cystoscopy: a double-blind controlled study of demeclocycline hydrochloride and sulfamethoxypyridazine.


Restoration of fertility following unilateral orchiectomy and radiation therapy for testicular tumors.


The diagnostic use of radioactive isotopes in haematology.


Drug resistance of urinary tract pathogens cultured from ambulatory patients in the community in 1969.


Antiviral chemotherapy.

Antiviral chemotherapy.


Immunoglobulin deficiencies in Burkitt's lymphoma.


Biologic activity of adriamycin (NSC-123127) in microbial systems.


Phase I study of phenesterin (NSC-104469).


Histoplasmosis--quo vadis?

Histoplasmosis--quo vadis?


Neurofibroma of the recurrent laryngeal nerve.


IgM antibodies of the monkey: specificity to chlamydia agents.


Genetic polymorphism of glycerol-3-phosphate dehydrogenase (E.C.: 1.1.1.8). I. Transspecific variability of G-3-PD subunit B in Primates.


Cell culture of three antibody-producing murine plasmacytomas.


Transspecific variability of glutamic oxaloacetic transaminase (E.C. 2.6.1.1) in Primates.


Abnormal size profiles of soluble macromolecules from azo-dye liver tumors.


Surveillance of the fetus during the intrapartum period.


Determinants of body representation in postcentral gyrus of macaques.


Transfection of Escherichia coli and Salmonella typhimurium spheroplasts: host-controlled restriction of infective bacteriophage P22 deoxyribonucleic acid. Under proper conditions, one infective center was obtained for 3 x 10(8) molecules of P22 phage deoxyribonucleic acid (DNA) when lysozyme-ethylenediaminetetraacetic acid spheroplasts of Escherichia coli were transfected in the presence of 25 mug of protamine sulfate per ml. A 3- to 50-fold B-specific and K-specific E. coli restriction of the incoming P22 DNA was observed. When P22 DNA-infected E. coli spheroplasts were plated with infertile r(LT) (+)m(LT) (+)Salmonella typhimurium indicator, an additional 70-fold restriction was observed. In the presence of protamine sulfate, penicillin spheroplasts of S. typhimurium SB1330 could be transfected b P22 DNA with efficiencies sometimes approaching those obtained with the E. coli spheroplasts; thus, facilitation of transfection by protamine sulfate is not limited to E. coli or to lysozyme-ethylenediaminetetraacetic acid spheroplasts. The application of these results to studies of transfection among other genuses and to studies of in vitro host-controlled restriction and modification for the two loci in S. typhimurium and the one locus in E. coli is discussed.


Comparison of Bacillus cereus bacteriophages CP-51 and CP-53. Transducing bacteriophages CP-51 and CP-53 were compared. Unlike CP-51, CP-53 appeared to be a lysogenizing phage. CP-51 gave greater frequencies of co-transduction for linked markers than did CP-53. CP-51 was found to be a larger phage which carried more deoxyribonucleic acid (DNA) than CP-53. CP-51 DNA contained about 43% guanine plus cytosine and in addition contained 5-hydroxymethyluracil in place of thymine. CP-53 DNA contained no unusual bases; its guanine plus cytosine content was 37%.


Review of research related to work activities for aged residents of long-term-care institutions.


The effect of intermaxillary elastic force on the temporomandibular articulation in the growing macaque monkey.


Heterotopic ossification in the paraplegic patient.


Studies on prostaglandin antagonists.

Studies on prostaglandin antagonists. 1. Three prostaglandin antagonists have been examined for their ability to block PGE(2) and PGF(2alpha) on human, guinea-pig and isolated rat gastrointestinal muscle.2. 7-oxa-13-Prostynoic acid was either a non-selective antagonist, or was ineffective on the tissues studied; it had marked spasmogenic activity on the rat fundus.3. 1-Acetyl-2-(8-chloro-10,11-dihydrodibenz (b,f)(1,4) oxazepine-10-carbonyl) hydrazine selectively antagonized the excitatory effects of PGE(2) and PGF(2alpha) in guinea-pig and rat tissues, but not in human muscle.4. Polyphloretin phosphate selectively antagonized the excitatory effects of prostaglandins in both human and guinea-pig muscle preparations, but it caused stimulation of the rat fundus.5. All the antagonists lowered the tone in many tissues. They also reduced contractions caused by potassium.6. None of the compounds blocked the inhibitory effect of PGE(2) on intestinal circular muscle.7. The implication of these results on the nature of prostaglandin receptors, and the value of each compound as a prostaglandin antagonist are discussed.


Comparative dominant lethal studies with phenylbutazone, thio-TEPA and MMS in the mouse.


Template preference of polymerases and its relevance to oncogenic RNA virus replication.


-aminooxy-acid derivatives with potent antituberculotic effect.


Scanning electron microscopy of the lung.


On the teratogenic effect of thymidine and its suppression by deoxycytidine in Drosophila melanogaster.


Quantitative structure--activity relationships in leucomycin and lincomycin antibiotics.


Studies on the absorption and metabolism of folic acid. I. Folate absorption in the dog after exposure of isolated intestinal segments to synthetic pteroylpolyglutamates of various chain lengths. Folic acid absorption was studied in anesthetized dogs by determining the amount and chemical nature of folate in venous blood emerging from isolated intestinal segments containing free folic acid and/or pteroylpolyglutamates of a known chain length. Chromatographically pure test materials placed in the lumen were prepared by unambiguous solid phase synthetic methods. This synthetic procedure not only yields compounds of known structure, it also provides a means by which glutamic acid residues at any given position in the gamma glutamyl chain can be made radioactive. For example, teropterin (pteroyltriglutamate) was synthesized in such a way that (14)C was present only in the middle glutamic acid unit. Suitable placement of label permitted assessment of the extent of peptide cleavage. The action of plasma conjugase was inhibited by copper chloride. Plasma samples were analyzed by Lactobacillus casei and Streptococcus faecalis assay, by column chromatography, and by quantitative measurement of pteridine-bound radioactivity. It was observed that biologically active folate appeared in the mesenteric vein with either pteroylmono-, di-, tri-, penta-, or heptaglutamate in the lumen. Generally speaking the absorption rate appeared to be inversely related to the length of the gamma glutamyl side chain. Roughly twice as much folic acid appeared in the circulation from (3)H-labeled pteroylmonoglutamate as from (14)C-labeled pteroylpentaglutamate when equimolar amounts of each were placed simultaneously in a single intestinal segment. Pteroylmonoglutamate appeared to be the predominant form entering the blood from each of the precursors tested. However, evidence was obtained that pteroyldiglutamate may enter the mesenteric vein soon after placing pteroyldi-, or triglutamate in the lumen, but not with the higher polyglutamates. Comparison of radioactivity and biological activity patterns suggests little conversion, if any, to reduced or methylated forms during the first 30 min of passage through the intestinal mucosa. We conclude that both pteroylmonoglutamates and pteroyldiglutamates may across the intestinal mucosa of the dog, and that reduction and methylation are not essential to the absorption process.


A preservative for urine specimens in transit to the bacteriological laboratory.


Excretion and metabolism of a nonsteroidal antiinflammatory agent, 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxanilide 1,1-dioxide, in rat, dog, monkey, and man.


A new cetrimide medium for the detection of Pseudomonas aeruginosa.


Comparison of Hoyle's medium and Billings' modification of tinsdale's medium for the bacteriological diagnosis of diphtheria.


Septic arthritis due to Pseudomonas aeruginosa.


Long-term treatment of hyperlipidemic patients with clofibrate.


Psychiatric side effects of levodopa in man.


Presence of neutralizing antibody against the 229E strain of coronavirus in the sera of residents of Sendai.


What's new-1970.

What's new-1970.


Acute leukemia, following treatment with irradiation and alkylating agent.


Neurofibromatosis, polycystic kidneys, and hypernephroma.


President's address. A conscience--its anatomy and its application to the practice of medicine.


Insurance and medicine--the changing scene.


Transplantation in protozoa.

Transplantation in protozoa.


A lipoprotein characterizing obstructive jaundice: isolation and analysis.


Specificity of aggregation in Porifera.

Specificity of aggregation in Porifera.


Cell aggregation: molecular specificity in outer cell surface materials.


Immunity in insects.

Immunity in insects.


Human carbonic anhydrases. VII. A new C type isozyme in erythrocytes of American Negroes.


A new RNA synthesis mutant of E. coli.

A new RNA synthesis mutant of E. coli.


Echo- and electro-encephalography in ruptured cerebral arterial aneurysms.


Structural and activational zinc in Escherichia coli alkaline phosphatase.


Isolation, amino acid composition and physical properties of chloroplast thylakoid protein from Euglena gracilis.


Rate studies of polysaccharide biosynthesis from guanosine diphosphate  -D-glucose and guanosine diphosphate  -D-mannose. With enzyme preparations from Phaseolus aureus seedlings, the initial rate of (14)C-labelled polysaccharide formation from GDP-alpha-d-[(14)C]glucose is not increased by additions of GDP-alpha-d-mannose. However, final incorporation is increased by addition of GDP-alpha-d-mannose, since the total reaction-time is extended. In contrast, the initial rate of (14)C-labelled polysaccharide formation from GDP-alpha-d-[(14)C]mannose is increased by all concentrations of GDP-alpha-d-glucose that are less than that of the GDP-alpha-d-[(14)C]mannose. Maximum stimulation of the initial rate occurs at a GDP-alpha-d-[(14)C]mannose/GDP-alpha-d-glucose concentration ratio of about 4:1. However, eventual incorporation from GDP-alpha-d-[(14)C]mannose is decreased by the addition of GDP-alpha-d-glucose, since the reaction rate falls off sharply after about 2min. Reciprocal plots of (14)C-labelled polysaccharide formation from GDP-alpha-d-[(14)C]mannose result in biphasic graphs. The two straight-line portions of the plot are joined by a curved line in the concentration range between 2-3 and 50mum. Extrapolated K(m) values for the two linear components are 0.4-1.0 and 700-1500mum. The effect of GDP-alpha-d-glucose on the kinetics of (14)C-labelled polysaccharide formation from GDP-alpha-d-[(14)C]mannose is complex, and depends on relative concentrations of the two sugar nucleotides. (14)C-labelled polysaccharide formation from GDP-alpha-d-[(14)C]glucose also results in biphasic reciprocal plots. One component appears to have K(m) about 2-3mum, the other about 200-400mum. In this reaction, GDP-alpha-d-mannose appears to be a competitive inhibitor with K(i) 20-30mum. With particulate preparations of P. aureus, GDP-alpha-d-[(14)C]glucose appears to be a precursor for the synthesis of one polysaccharide, a glucomannan, the mannose moieties of which are derived from an intermediate existing in the particulate preparation. From the rate results, GDP-alpha-d-[(14)C]mannose appears to be a precursor for at least two polysaccharides, one of which is a glucomannan.


Chemotaxonomy and biosynthetic relationships of Boletineae pigments.


The binding of calcium ions by human erythrocytes.


Motion detection in man and other animals.


Pathological aspects of cerebral accidents in arterial hypertension.


The cerebellum of Galago and Tupaia. II. The early postnatal development.


Congenitally malformed female infant with hairy pinnae.


Enzymatic catalysis in solidified media.


Studies on inherited antigenic variation of human serum  -lipoprotein by passive hemagglutination. 3. Screening for antibodies in sera from multiply transfused patients.


Comparative study of argon and ruby retinal damage thresholds.


Human carbonic anhydrase B. Location of tyrosine residues that react with tetranitromethane.


The interconvertibility of various bacterial transfer ribonucleic acids between an active and an inactive stable configuration.


The subunit structure of human thyroxine-binding prealbumin.


Evidence for multiple thyroxine-binding sites in human prealbumin.


Fetal and maternal features of antenatal bacterial infections.


The role of growth hormone in the pathogenesis of diabetes mellitus in childhood.


Unnecessary and preventable hospitalizations: report on an internal audit.


Carbenicillin and gentamicin: pharmacologic studies in patients with cystic fibrosis and pseudomonas pulmonary infections.


Health care in America: a heretical diagnosis.


Experimental infection with Pseudomonas aeruginosa in mice. II. The fate of highly and low virulent strains in the peritoneal cavity and organs of mice.


Replication and synthesis of Japanese encephalitis virus ribonucleic acids in Vero cells.


Slime production by Pseudomonas aeruginosa. I. Conditions for slime production by the cellophane plate method.


Studies on the persistent infection with measles virus in HeLa cells. II. The properties of carried virus.


Studies on the persistent infection with measles virus in HeLa cells. 3. Immunolysis of cells in carrier state by anti-measles sera.


Impairment of recent memory by marihuana and THC in rhesus monkeys.


Antigens of developing Drosophila melanogaster.


Survival of microorganisms in a simulated Martian environment.


Survival of blue-green algae under primitive atmospheric conditions.


Autolytic nature of iridescent lysis in Pseudomonas aeruginosa.


Substrate specificity of the paraffin hydroxylase of Pseudomonas aeruginosa.


Enzyme purification by electrodecantation. 1. Electrodecantation has been applied to the initial fractionation from crude material of pig kidney beta-d-glucosidase and sheep testicular N-acetylglucosaminidase. 2. The isoelectric points determined by isoelectric focusing were pH4.9 for the beta-d-glucosidase and pH6.3 for the N-acetylglucosaminidase. 3. Electrodecantation of pig kidney extract and sheep testicular extract was carried out at pH4.9 and 6.3 respectively. 4. A six- to ten-fold increase in specific activity could be obtained with good recoveries after a single cycle of electrodecantation. 5. The technique has also been used to purify further an extracellular Bacillus subtilis protease preparation. 6. Attempts to use electrodecantation for the concentration of very dilute enzyme solutions resulted in considerable loss of activity. 7. The limitations and potential use of the technique in laboratory-scale enzyme preparation are discussed.


Carbohydrate content of insoluble elastins prepared from adult bovine and calf ligamentum nuchae and tropoelastin isolated from copper-deficient porcine aorta. 1. Insoluble elastin has been prepared by several different methods from adult bovine and calf ligamentum nuchae. Highly purified tropoelastin has been prepared from copper-deficient porcine aorta. 2. Amino acid analyses indicated that all preparations, except that obtained from calf ligamentum nuchae by using an EDTA extraction followed by collagenase digestion (preparation E6), were typical of pure elastin having high concentrations of hydrophobic and low concentrations of hydrophilic amino acids. Preparation E6 was found to contain approx. 40% collagen. 3. The determination and composition of the carbohydrates associated with these preparations is reported. With the exception of preparation E6, the insoluble elastins contained only trace amounts of neutral sugars (0.13-0.35%, w/w) and amino sugars (0.01-0.06%, w/w). The porcine tropoelastin contained virtually no carbohydrate. 4. The results suggest that carbohydrate analyses can yield valuable information about the purity of elastin preparations.


The  -amylase of the Beetle Callosobruchus chinensis. Properties. C. chinensis larval amylase is activated by Ca(2+) and inhibited by Cl(-) and EDTA (K(i) 6.7x10(-3)m). GSH and 2-mercaptoethanol activate, presumably at different sites, as 2-mercaptoethanol interferes with Ca(2+) activation, whereas GSH enhances it. The inhibition by iodoacetic acid and N-ethylmaleimide (K(i) 1.55x10(-2)m) suggest that free thiol groups are essential for activity. The pH optimum of 5.2-5.4 is moved to 5.6-5.8 by Ca(2+) and 2-mercaptoethanol. The activation energy is 7270 cal/mol, and is not affected by Ca(2+) and 2-mercaptoethanol. K(m) for soluble starch is 2.3mg/ml.


Effect of osmotic shock on tetracycline resistance in Escherichia coli bearing an R-factor. 1. Escherichia coli with an R-factor conferring resistance to tetracycline was induced to high-degree resistance by pre-exposure to the antibiotic. The degree of resistance was drastically lowered by subjecting the cells to osmotic shock. 2. Resistance to tetracycline was rapidly restored by incubating the shocked cells in a glucose-salts medium containing shock proteins prepared from tetracycline-sensitive and -resistant cells. Resistance was also restored by incubating the cells in a complex medium without shock protein. 3. The initial recovery of resistance was followed by a secondary fall in resistance when the cells were cultured in complex medium; this secondary fall was largely prevented by the addition of a low concentration (10mug/ml) of tetracycline to cells. The secondary fall was significantly less in shocked E. coli cells harbouring a mutant R-factor in which tetracycline resistance is largely constitutive. 4. Tetracycline resistance was also transiently depressed by treating R-factor-bearing cells with EDTA in tris buffer. 5. The significance of these results in relation to the mechanism of tetracycline resistance in R-factor-bearing cells is discussed.


The anionic polymers in the cell wall of Bacillus subtilis var. niger grown in phosphorus-limiting environments supplemented with increasing concentrations of sodium chloride.


Surface ionization ratios for electrons in the energy range 3-11 MeV and the implications for treatment of superficial lesions.


Histochemical and physiological study of chromaffin cells in the skin of the medaka, Oryzias latipes.


Intermarriage patterns and blood group gene frequencies of the Bundi people of the New Guinea highlands.


Analysis of the delayed-alternation deficit produced by dorsolateral prefrontal lesions in the rhesus monkey.


Biochemical basis for depigmentation of skin by phenolic germicides.


Experimental vasospasm, acute and chronic, due to blood in the subarachnoid space.


Pathological findings in acute experimental spinal cord trauma.


Microangiographic observations of the experimentally traumatized spinal cord.


Pain threshold alterations by brain stimulation in the monkey.


Influence of ischemia and hypothermia on the ability of the transplanted primate lung to provide immediate and total respiratory support.


On identification of hypothalamo-hypophysial control and feedback relationships with the thyroid gland.


Reconstructive surgery for the treatment of mitral incompetence. Early and late results in 91 patients.


Platelet aggregation during progressive hemorrhagic shock in pigs. Possible effects on the postperfusion syndrome.


Disodium cromoglycate (Intal).

Disodium cromoglycate (Intal).


Haemolytic disease of the newborn due to small c incompatibility.


Epilepsy: practical medical treatment.

Epilepsy: practical medical treatment.


Osteoarthritis.

Osteoarthritis.


An intravenous hyperalimentation cart.

An intravenous hyperalimentation cart.


Recurring patterns during development in primitive organisms.


Interrelationships of intussusception and the integumentary system.


Paraformaldehyde and s-collidine--a fixative for preserving large blocks of tissue for electron microscopy.


The ubiquity and significance of human ferritin.


The life expectancy of head injured men with and without epilepsy.


The role of the histidine side chains in the catalytic activity of B. cereus expopenicillinase.


PHA short-term culture of lymphocytes in acute leukemia during remission. Relation with therapy.


Maturation of leukaemic blast cells.

Maturation of leukaemic blast cells.


Granulocyte function in patients with brain damage and anoxia.


Diagnosis of quinine hypersensitivity, use of platelet factor 3 and acid phosphatase availability tests.


Sickle cell trait in a caucasian population. Proportion of hemoglobin S in hemolysates from Saudi Arabs.


Study of hemoglobins in a population of Yucatan. Comparison with other Mexican groups.


Hemolytic anemia associated with decreased concentration of reduced glutathione in red cells.


The value of the platelet adhesiveness test in the assessment of abnormalities of platelet function.


Pentose-phosphate pathway of leucocytes.


Enzyme cytochemistry of the energy metabolism in the cells of normal human bone marrow.


Aplastic anemia: some clinical and laboratory aspects and an evaluation of the androgen-glucocorticoid treatment.


Toxoplasmosis. With special reference to transmission and life cycle of Toxoplasma gondii.


Managing ulcerative and granulomatous bowel disorders.


Structure and function of amylases. I. The subunit structure of porcine pancreatic  -amylase.


Properties and subunit structure of the B component of Pseudomonas putida tryptophan synthetase.


A thiol-dependent cathepsin IV in rat liver lysosomes.


The effect of ergosterol on the fatty acid composition of Tetrahymena pyriformis.


Infectious influenza virus-antibody complex.


The binding of thiophenols to bovine carbonic anhydrase.


Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide.


The reaction of Pseudomonas azurin with hydrated electrons.


pH control of the chlorophyll a fluorescence in algae.


Albumin synthesis by the perfused rat liver. A comparison of methods with special reference to the effect of dietary protein deprivation. 1. Isolated perfused rat livers were used to study synthesis of albumin after donors had been fed on normal or protein-free diets. 2. Methods of determining the liver's ability to produce albumin included incorporation of [(14)C]carbonate, [(3)H]lysine and [(14)C]arginine, as well as a direct method based on a heterologous perfusing system of rat erythrocytes and rabbit plasma. 3. Livers from protein-deprived rats were found to form extremely little urea and not to incorporate (14)CO(2) into [(14)C]urea, but they were capable of producing [(14)C]urea from [(14)C]arginine and of incorporating the latter and [(3)H]lysine into albumin. 4. By immunological means these lives were found to synthesize less albumin than normal, but their ability was only slightly impaired when related to body weight or liver weight. 5. These findings are consistent with a block in urea-cycle enzymes with relative integrity of arginase activity and of amino acid activation.


Excellence need not cost more. Relating a free clinic's services to the patient's convenience and feelings.


Some features of the bacterial membrane studied with the aid of a new fractionation technique. Membranes of Bacillus megaterium and other bacteria were bound to crystals of cadmium lauroylsarcosinate and were resolved into nine lipoprotein fractions by elution with potassium chloride and sodium deoxycholate solutions. The fractions differed widely in protein/lipid ratio. Some major protein species were probably common to all the fractions, but the phospholipid composition showed some variation. Electron-microscopic examination after negative staining revealed that material in certain fractions was in the form of particles of diameter about 12nm, and other fractions consisted of amorphous aggregates. The composition of the membrane in terms of the nine fractions was influenced markedly by the conditions of culture of the bacteria. Radioactive-labelling experiments suggested that some fractions served as precursors of others, and one fraction appeared to contain the attachment points of the DNA.


Evoked responses after hemispherectomy.

Evoked responses after hemispherectomy.


Treatment of pneumonia in children with Cleocin palmitate.


Chlorpropamide in diabetes insipidus in childhood.


Pyrosis and pregnancy.

Pyrosis and pregnancy.


A controlled study of a weight reduction regimen.


Biphenabid (Probucol): a new hypocholesterolemic agent.


Evaluation of clinical efficacy of pimozide as maintenance therapy in chronic schizophrenic patients.


A pilot study of pimozide in chronic schizophrenic patients.


Clinical, toxicological and electroencephalographic study with SCH-12,679 in chronic schizophrenics.


Unusual electroencephalographic and clinical evolution of a case of meningioma of the left temporo-occipital convexity.


Borderline cases of petit mal status.

Borderline cases of petit mal status.


Intestinal trehalase activity in man and nonhuman primates.


Herpesvirus neutralization: the role of complement.


Acute viral infection: tissue injury mediated by anti-viral antibody through a complement effector system.


Induction of thyroiditis in the rabbit by intravenous infection of papain-treated rabbit thyroglobulin.


Effect of antigen variation on production of antibody in canine tracheal secretions.


Immunobiology of human lymphoid cell lines. I. Immunoglobulin biosynthesis in cultures from Hypogammaglobulinemias and paraproteinemias.


Immunoglobulin classes in aquatic mammals. Characterization by serologic cross-reactivity, molecular size and binding of human free secretory component.


Antibody production in normal children receiving penicillin at birth.


Effect of selected lipids and surfactants on immunogenicity of several bacterial antigens.


Release of macrophage migration inhibitory factor by virus-infected spleen cells.


Schistosomal egg antigen-induced lymphocyte blastogenesis in experimental murine Schistosoma mansoni infection.


Nitrofuryl heterocyclics. 2.

Nitrofuryl heterocyclics. 2.


Biotransformation of the sedative 1-(p-chlorophenyl)-2,2-dimethyl-1,3-propanediol 3-carbamate in humans and five animal species.


Synthetic biologically active polymers. 8. Antibacterial activity of some sulfonamide-dimethylolurea copolymers.


2-(5-nitro-2-thienyl)cinchoninic acids.

2-(5-nitro-2-thienyl)cinchoninic acids.


Gelfilm-induced neotympanic membrane in tympanoplasty.


Simultaneous transmission of three stable genotypes in Drosophila melanogaster.


Molecular aspects of lipopolysaccharides.


L-dopa and behavior.

L-dopa and behavior.


A miniaturized pump oxygenator for evaluation of peripheral circulatory changes induced by long-term weightlessness in rats.


Basic studies on Hirudo medicinalis for a space experiment. I. Behavior of Hirudo medicinalis in natural environment.


Optimizing thermal and radiation effects for bacterial inactivation.


Light and electron microscope studies of the autonomic nervous system in experimental and human American trypanosomiasis.


Studies on bilirubin in amniotic fluid with special reference to liver function tests.


Immunoglobulin A and M levels in premature infants with gastroenteritis.


Pulpal changes following the reimplantation of teeth in dogs: a histological study.


A basic study in semi-buried implants and osseous attachments for application to amputation prosthetic fitting.


Bulk separation of neurones and glia: aa comparison of techniques.


Elderly people and their tubercle bacilli.


Post-transfusion hepatitis: a review and prospectus.


Studies of the EB virus-related antigens of human leukocyte cell lines.


Macroglobulinemia. Report of first three cases from India.


Excitatory effects following habituation of prey-catching activity in frogs and toads.


Agglutinins in Widal, Weil-Felix and Brucella agglutination test.


Charting the Indiana health care dollar.


Mycobacteria from sputa in Surat with special reference to atypical varieties.


Serial pulmonary perfusion scanning in radiation therapy for bronchogenic carcinoma.


Fast neutron activation analysis of the major body elements.


Cyclotron-produced 157Dy compared with 18F for bone scanning using the whole-body scanner and scintillation camera.


Pharmacological studies on new potent central depressants, 8-chloro-6-phenyl-4H-s-triazolo [4,3a][1,4] benzodiazepine (D-40tA) and its 1-methyl analogue (D-65MT).


Significance of ATP-splitting activity of rat peritoneal mast cells in the histamine release induced by exogenous ATP.


Rabbit liver beta-glucuronidase. I. Purification and its properties.


An introduction to general anaesthesia of experimental animals.


Oculo-genital disease.

Oculo-genital disease.


Intranasal Intal (disodium cromoglycate).


Ferritin synthesis by free and membrane-bound (poly)ribosomes of rat liver.


Isolation of Mycoplasma arginini from commercial bovine sera and its implication in contaminated cell cultures.


Atropine influence on altered hemodynamics of the primate kidney in hemorrhagic shock.


Autoimmunity in methylcholanthrene-induced and spontaneous thyroiditis in Buffalo strain rats.


The effect of cyanogen iodide and mercuric chloride on the permeability of cells of Pseudomonas aeruginosa and the antagonistic action of sulfhydryl compounds.


Serological response of rhesus monkeys (Macaca mulatta) to immunization and infection with Pasteurella pestis.


Plasma lipid levels during pregnancy in the rhesus monkey (Macaca mulatta).


An Rh gene complex which results in a "new" antigen detectable by a specific antibody, Anti-Rh 33.


An approach to diagnosis and therapy of thyroid tumors.


I-, MN- and Pr1/Pr2-activity of human erythrocyte glycoprotein fractions obtained by ficin treatment.


Zonal centrifugation of soluble immune complexes. 2. Analysis of antigen-antibody mixtures at equilibrium over various parts of the precipitin curve.


Allotypes of serum alpha2-macroglobulin beta-lipoprotein and immunoglobulins in the domesticated sheep (Ovis aries).


Characterization of virus-specific antigen in cell culture infected with lymphocytic choriomeningitis virus.


Antigen-induced lymphocyte transformation in vitro during primary immunization in man. 1. Development and course.


Attempts to establish Neisseria meningitidis in gnotobiotic animals.


Antigen-induced lymphocyte transformation in vitro during primary immunization in man. 2. Correlation with development of cellular and humoral hypersensitivity.


Studies on antibody-containing cells in lymph nodes and the lymph of rabbits immunized with human immunoglobulin G according to various schedules.


Trimethoprim for the prevention of overgrowth by swarming Proteus in the cultivation of gonococci.


Sorption of DNA and RNA during transformation of Neisseria meningitidis.


Inhibition of transformation in Neisseria meningitidis by acriflavin and ethidium bromide.


Antibodies in bronchial secretions following natural infection with Mycoplasma pneumoniae.


Observations on the caudal end of the spinal cord.


Mechanism of enhancement of Newcastle disease virus growth in cultured cells by co-infecting hog cholera virus.


Purification of rabies virus from tissue culture.


Molecular properties of the multiple aspartate aminotransferases purified from rat brain.


Enzymatic repair of DNA. 3. Properties of the UV-endonuclease and UV-exonuclease.


Molecular weight, buoyant density, and composition of active subunits of rat liver ribosomes.


The effect of season on occurrence of ovulation in the rhesus monkey.


Precipitation of  125 I-labeled lipoproteins with specific polypeptide antisera. Evidence for two populations with differing polypeptide compositions in human high density lipoproteins.


Studies on phytohemagglutinins. VII. Effect of Mn 2+  and Ca 2+  on hemagglutination and polysaccharide precipitation by phytohemagglutinin of Pisum sativum l.


The cervical mucus secretion of the bonnet monkey (M. radiata): anatomical basis and physiological regulation.


Reduction of perinatal mortality from Rh isoimmunization.


The effects of dithiocarbamoylhydrazine derivative upon ovarian function and structure in the bonnet monkey (Macaca radiata).


Incidence of hepatitis-associated antigen in a Toronto hospital.


Evaluation of mitogillin (NSC-69529) in the treatment of naturally occurring canine neoplasms.


On the timing and place of action during embryogenesis of the female-sterile mutants fused and rudimentary Drosophila melanogaster.


The mechanism of pattern reconstruction by dissociated imaginal discs of Drosophila melanogaster.


Congenital rubella syndrome: clinical, virological and immunological aspects.


Identification of Corynebacterium diphtheriae by immunofluorescence during a diphtheria epidemic. During a large epidemic of diphtheria, the technique of immunofluorescence was applied to specimens obtained from 310 patients, 77 of whom were diagnosed clinically as having the disease. The technique made use of commerical fluorescent antisera prepared against the somatic antigens of Corynebacterium diphtheriae. The results obtained by immunofluorescence of slides prepared directly from swabs were found to be unsatisfactory but when the swabs were subjected to prior incubation in a growth medium the results of immunofluorescence and bacterial culture agreed in 95% of specimens. Immunofluorescence applied to bacterial colonies obtained on primary isolation agreed completely with definitive bacterial identification. These two methods for the rapid identification of C. diphtheriae appeared to be as reliable as formal cultural and biochemical methods and could be usefully and economically applied to the examination of large numbers of clinical specimens during an epidemic.


Specificity of antibodies against human IgG myeloma proteins precipitating neither Fab nor Fc fragments.


Quantitative estimation of protein by electroimmunodiffusion on Cellogel acetate membranes.


Pitfalls of Australia antigen detection and screening.


A study of the nascent polypeptides synthesized on the free polyribosomes of rat brain in vivo.


Isolation of two pantotheine-containing acidic proteins from monkey brain.


Amniotic fluid: its physiology and pathology.


The value of  67 Ga scanning in the evaluation of liver involvement in Hodgkin's disease: comparison with  99m Tc-sulfur colloid.


Survival of micro-organisms in space. Results of Gemini-IX-A, Gemini-XII, and Agena-8 satellite-borne exposure and collection experiments.


Release of microbial contamination from fractured solids.


Evaluation and comparison of serological procedures for hepatitis-associated antigen (HAA).


Rh blood groups of Australian aborigines in the tribe containing the original Rh-null propositus.


In vitro potency results from a collaborative study of RhO(D) immune globulin reference preparation.


Observations of the number of available c,D, and E antigen sites on red cells.


Early 'enzyme' Rh antibodies and second pregnancies.


The occurrence of hyaluronic acid and-or hyaluronidase labile substances in the salivary gland cells of insects with adverse feeding habits.


Epididymal luminal contents labelling after  14 C- or  3 H-lysine administration in the mouse.


Cytochemical studies on the appearance of lysosomal enzymes in unusual structures of rat liver cells.


A simple new synthesis of cytidines.

A simple new synthesis of cytidines.


The present position of hemoglobin research.


Effect of serum on the yield of lymphocytic choriomeningitis virus in baby hamster kidney cells. The yields of the Armstrong and WE strains of lymphocytic choriomeningitis virus in baby hamster kidney (BHK) cells cultivated in either bovine, calf, fetal bovine, or horse serum were investigated. Lines of BHK cells were established in these sera. When the infected cell lines were observed by immunofluorescence, the per cent fluorescing cells for a given virus strain did not vary. However, for both strains, the extracellular virus yields per cell were significantly greater in the fetal bovine-cell line than in the other serum-cell lines.


Chromomycin A 3 , an antitumor antibiotic: tissue distribution studies in mice as measured by microbial assay. A microbiological assay has been developed for chromomycin A(3), an antitumor antibiotic showing promise in human trials. The assay bacterium is a derived strain of Streptococcus faecalis resistant to methotrexate. Studies with mice revealed that relatively high concentrations of this antibiotic were maintained in the blood, kidneys, and liver of mice after a single-dose intraperitoneal injection of the drug.


L-Asparaginase from Proteus vulgaris.

L-Asparaginase from Proteus vulgaris. To produce an immunologically and enzymologically new type of l-asparaginase, 108 strains of bacteria were screened for enzyme production. As a result, 13 bacteria belonging to the genera Alcaligenes, Bacterium, and Proteus were found to produce l-asparaginases in high levels. Among these l-asparaginases, partially purified l-asparaginases from B. cadaveris and P. vulgaris showed antitumor activity. A partially purified l-asparaginase preparation of P. vulgaris did not react with the antibody of Escherichia colil-asparaginase on the Ouchterlony agar plate. Culture conditions for the production of l-asparaginase by P. vulgaris were investigated in detail. The enzyme was produced in high yields when cells were grown aerobically in a medium containing sodium fumarate and corn steep liquor. The addition of glucose or ammonium ion to the medium, however, resulted in depressed production of l-asparaginase. Under the optimum conditions, 3,700 international units of l-asparaginase was obtained from 1 liter of culture medium.


Simultaneous use of contrasting fluorochromes to separate measles and canine distemper viruses in a common system. Measles and canine distemper viruses were grown together in a Vero monkey kidney cell line. Each virus could be identified and individually titrated by using the color contrast produced by the reddish tetra-methyl rhodamine isothiocyanate-tagged antimeasles conjugate and the green fluorescein isothiocyanate-tagged antidistemper conjugate. Both blue light and green light were used for the excitation of the fluorochromes. Incident light was transmitted to the specimen by a vertical illuminator of the Ploem type.


Repair of injury in freeze-dried Salmonella anatum. Repair of injury induced by freeze-drying Salmonella anatum in nonfat milk solids occurred rapidly after rehydration. Injury in surviving cells was defined as the inability to form colonies on a plating medium containing deoxycholate. Death was defined as inability to form colonies in the same medium without this selective agent. The rate of repair of injury was reduced by lowering the temperature from 35 C to 10 C and was extremely low at 1 C. Repair was independent of influence of pH between 6.0 and 7.0. Repair did not require synthesis of protein, ribonucleic acid, or cell wall mucopeptide, but did require energy in the form of adenosine triphosphate (ATP) synthesized through oxidative phosphorylation. The requirement for ATP was based on dinitrophenol or cyanide interference with repair. Dinitrophenol activity was pH-dependent; no repair occurred at pH 6.0 and some repair was observed at pH 6.5 and above. Injured cells were extremely sensitive to low concentrations of ethylenedinitrilotetraacetate. This indicated that freeze-drying injury of S. anatum may involve the lipopolysaccharide portion of the cell wall and that repair of this damage requires ATP synthesis.


Subtyping of pyocin type 1 Pseudomonas aeruginosa: one year of experience. Subtyping of pyocin type 1 Pseudomonas aeruginosa strains has increased the sensitivity of an epidemiological tool used by the Hospital Infection Committee in surveillance studies.


Antibacterial activity of ronidazole.

Antibacterial activity of ronidazole. Ronidazole, a nitroimidazole that has in vivo antiparasitic and antimycoplasmal activity, also has some in vivo antibacterial activity.


The systemic and coronary hemodynamic effects of iproveratril.


Gastric secretory and serologic studies on patients with neoplastic and immunologic disorders.


Primary sequence of tRNA-Val-1 from Escherichia coli B. II. Isolation of large fragments by limited digestion with RNases, and overlapping of fragments to reduce the total primary sequence.


Metabolic pathways in Tetrahymena: distribution of carbon label by reactions of the tricarboxylic acid and glyoxalate cycles in normal and desmethylimipramine-treated cells.


Content of  -tocopherol in some blue-green algae.


Alterations in the structure of deoxyribonucleic acid on chemical methylation.


Crotonic acid, an artefact in screening for organic acidaemias.


Augmentation of the hexose monophosphate shunt in leukemic lymphocytes after plasma fractionation.


Specific and non-specific precipitins in the serum of patients suffering from "pigeon breeders' disease".


Facial parasympathetic innervation of the choroidal blood vessels in monkeys.


Effects of longstanding stepwise increments in eye pressure on the rate of aqueous humor formation in a primate (Cercopithecus ethiops).


Obstetrical analgesia and anesthesia and resuscitation of neonates.


Driving point impedance characteristics of the head.


Periodontal effect of nonfunction in monkeys.


Behaviour of sonicated actin polymers: adenosine triphosphate splitting and polymerization.


Autogenous bone grafts: osseous coagulum and osseous retrograde procedures in primates.


Experience with silastic U-tube nephrostomy.


A search for a new method of urinary diversion.


Determinants of susceptibility to experimental enterococcal pyelonephritis.


A genetic study of temperature-sensitive mutants of the Bacillus subtilis bacteriophage phi 29.


TMV-RNA associated with ribosomes of tobacco leaves infected with TMV.


Viruses and renal carcinoma of Rana pipiens. X. Comparison of herpes-type viruses associated with Lucké tumor-bearing frogs.


Atypical band keratopathy in glaucomatous patients.


Norrie's disease. Congenital progressive oculo-acoustico-cerebral degeneration.


Drive and performance modification following multiple (dark-dark) shifts in the photoperiod.


Cardiac pacemaker experience. 1961-1970.


Effects of monamine oxidase inhibitors on qualitive alterations ( Transformation ) of the catalytic properties of amine oxidases.


Inhibition of rat and mouse brain monamine oxidases by (+)-amphetamine.


Antibiotic production and sporulation in Bacillus subtilis.


Speciation, transmission, and schizogony of leucocytozoon in corvid birds.


A and non- A immune response after oral and parenteral immunization of the hamster.


Pneumomediastinum in diabetic ketoacidosis: comments on mechanism, incidence, and management.


Listeria bacteremia with acute pericarditis.


Electrophoretic properties of haptoglobin and hemoglobin in four species of whales.


Control possibilities of implanted cardiac pacemakers.


Temperature optimum of alkaline phosphatases in some homeothermic and poikilothermic species.


Ferritin from different organs of man, rat, rabbit and pig.


Photo-oxidation of bovine oxymyoglobin in frozen solutions. The effect of redox active inorganic elements in muscle extracts.


Sweet-sensitive protein from the rat tongue: its interaction with various sugars.


The sensory cortex and tactile sensitivity.


Cervicothalamic tract in the rhesus monkey.


Conduction block of monkey dorsal rootlets by water and hypertonic saline solutions.


The early phase of reflex activity after spinal cord transection.


Trends in health delivery.

Trends in health delivery.


Hepatitis. 2: the scientific advances.

Hepatitis. 2: the scientific advances.


Influence of temperature on the growth of psychrophilic strains of Bacillus.


Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone.


Management of medical services.

Management of medical services.


Magnetically actuated pulse width control for implantable pacemakers. Its significance for the follow-up of patients and the reduction of current drain.


Coup and contre-coup injury: observations on the mechanics of visible brain injuries in the rhesus monkey.


Experimental radiofrequency telethermohypophysectomy.


Neurological involvement in the nevoid basal cell carcinoma syndrome.


Subdivision of the trigeminal sensory root. Experimental study in the monkey.


Subhuman primate diploid cells: possible substrates for production of virus vaccines. Results of a program for development of new cell lines suggest that it it possible to establish cell lines from both rhesus and African green monkeys which are comparable to diploid lines of human origin, and that these monkey lines should be candidates for use in the production of virus vaccines.


A scheme for screening blood samples to acquire lymphocyte cytotoxic antisera for tissue typing and results of an initial screening programme.


IgM lymphocytotoxic antibodies following multiple transfusion.


Evaluation of the effectiveness of hepatitis screening tests.


Water soluble I blood group substance in the secretions of rhesus monkeys.


Maternal serum and amniotic fluid Rh-D antibody levels in erythroblastosis fetalis.


Hemolytic disease of the newborn due to anti-Di b .


Studies on trypsin treatment of red cells with special reference to differences between trypsin preparations.


Serum antigens of cattle. 3. Immunologic assay of cattle haptoglobin.


Anti-D concentration in mother and child in haemolytic disease of the newborn.


What constitutes adequate routine Rh typing on donors and recipients?


Some measurements on amphibian oocyte nucleoli.


Morphogenesis and nature of the pigment granules in the adult human retinal pigment epithelium.


Immunologic studies in familial cardiomyopathy.


Cosmetic allergy. A comprehensive study of the many groups of chemical antimicrobial agents.


Multiple congenital giant nevocellular nevi with halos. A clinical and electron microscopic study.


The growth of Candida albicans in nutritive solutions given parenterally.


An occupational hazard--tuberculous paronychia. Report of a case.


A study of iron transfer from rabbit transferrin to reticulocytes using synthetic chelating agents.


The role of peroxidase in catalyzing oxidation of polyphenols.


The effects of gamma-hydroxybutyric acid on spontaneous locomotor activity and dopamine level in a selected strain of Drosophila melanogaster.


Species differences in the physiological disposition of 3-tritylthio-L-alanine (NSC83265).


Structure, function and evolution of primate hemoglobins. II. A survey of the oxygen-binding properties.


ACcumulation of polyglucose (CHO) in heat synchronized Tetrahymena pyriformis GL and its interaction with RNA.


Comparison of gamma-crystallins from frog and newt.


The distribution and composition of serum lipoproteins in eighteen animals.


The animal cell culture collection.

The animal cell culture collection.


the preparation of human kininogen. II. Further characterization of purified human kininogen.


The importance of theta and Ig hearing cells in the immune response to various antigens.


Endocrine secretion in vitro: prolactin.


Quantitation of the cell-mediated immune response. I. The number of cytolytically active mouse lymphoid cells induced by immunization with allogeneic mastocytoma cells.


Anthrax indirect microhemagglutination test.


Leukemia virus-induced immunosuppression. 8. Rapid depression of in vitro leukocyte migration after infection of mice with Friend leukemia virus.


The use of polyacrylamide gel as an immunoadsorbent for anti-2,4-dinitrophenyl antibodies.


The complement-fixation reaction in eguine infectious anemia: demonstration of inhibition by IgG (T).


Suppression of in vitro antigen-induced lymphocyte transformation by carrageenan, a macrophage-toxic agent.


Measurements of concentrations of human serum immunoglobulins.


The carcinogenic hydrocarbon benzo[a]pyrene in the soil.


A critical examination of bathing water quality standards.


Workshop on comparative pathology of hematopoietic and lymphoreticular neoplasms.


Determinants of cholesterol cholelithiasis in man and animals.


Spontaneous cleft lip and palate in a living nonhuman primate, Macaca mulatta.


Passive immunotherapy of leukemia and other cancer.


Social dominance and reproductive behavior in male rhesus monkeys.


The descending projections from the cortical visual fields of Macaca mulatta with particular reference to the question of a cortico-lateral geniculate-pathway.


Relative brain size: a critique of a new measure.


Paternalistic behavior in four species of Macaques.


Parameters of the wing imaginal disc development of Drosophila melanogaster.


Hypothalamic growth hormone releasing activity (GRA): characterization by the in vitro rat pituitary and radioimmunoassay.


Cryobiology of Neurospora crassa. II. Alteration in freeze response of Neurospora crassa conidia by additives.


Synthetic TRF (thyrotropin releasing factor) analogues. II. pGlu-N3imMe-His-Pro-NH2: a synthetic analogue with specific activity greater than that of TRF2.


Uptake of alanine, arginine and leucine by mammalian pancreatic beta-cells.


Play-mothering: the relations between juvenile females and young infants among free-ranging vervet monkeys (Cercopithecus aethiops).


Social behavior and 'agonistic buffering' in the wild barbary macague Macaca sylvana L.


Observations on copulation and seasonal reproduction of two species of spider monkeys, Ateles belzebuth and A. geoffroyi.


On the Recessus mesocoelicus in some primates.


The chromosomes of Aotus trivirgatus Humboldt 1812.


A note on the chromosomes of Aotus trivirgatus Humboldt 1812.


Evolution of acid phosphatase-1 in the genus Drosophila as estimated by subunit hybridization I: methodology.


The effect of radiation on small competing populations of Drosophila melanogaster. IV. Changes in longevity.


Pseudomonas septicemia. Ecthyma gangrenosum successfully treated with gentamicin and carbenicillin.


Cohesive properties of mammalian epididymal spermatozoa.


Microbial subterminal oxidation of alkanes and alk-1-enes.


Mechanism of eosinophilia and mast cell disruption in rats infected with the parasite Amplicaecum robertsi.


Clinical and neuropathological investigations of four cases of holoprosencephaly with arhinencephaly.


Chronic melioidosis: a case in Sydney.

Chronic melioidosis: a case in Sydney.


Vascular permeability responses in hypersensitivity. I. The tuberculin reaction.


Anti-red cell activity of lymphocytotoxic antibodies: an in vitro and in vivo evaluation.


Morphine tolerance and dependence induced by intraventricular injection. Injection of small quantities of morphine into the cerebral ventricular system of awake, relatively unrestrained, monkeys depressed or abolished operant food-reinforced lever pressing. After repeated injections progressively higher doses of morphine were needed to depress responding. Also, dependence could be demonstrated in these animals by precipitating specific abstinence signs with an antagonist.


Closed-circuit extracorporeal filtration of thoracic duct lymph.


Characteristics of animals maintained without splanchnic portal organs.


Chloroplast structure and biogenesis.

Chloroplast structure and biogenesis.


RNA polymerase.

RNA polymerase.


Peptide transport and metabolism in bacteria.


Morphology and distribution of diet-induced atherosclerosis in rhesus monkeys.


Woolsorters' disease. An experimental model.


The role of lymphocytes and other factors in antimicrobial cellular immunity.


Treatment of lead poisoning.

Treatment of lead poisoning.


Blood groups, myocardial infarction and angina pectoris among 10,000 adult males.


Diagnosis of adrenal disease by visualization of human adrenal glands with  131 I-19-iodocholesterol.


Inheritable and congenital hyperbilirubinemia. Models for the study of drug metabolism.


Rheumatic fever, throat cultures, and penicillin.


Population pressure on families: family size and child spacing.


The treatment of burns: a comparative trial of antibiotic dressings.


Hemodilution and distribution of systemic blood flow during total cardiopulmonary bypass in rhesus monkeys.


Hyperacute renal allograft rejection in presensitized monkeys.


Reinnervation of cardiac transplants.

Reinnervation of cardiac transplants.


Plasma gastrin levels in conscious rhesus monkeys.


The effects of surgery on bile secretion and composition.


Experimental spinal cord injury in monkeys: comparison of steroids and local hypothermia.


Effects of anesthesia and hypercarbia on the subcortical local blood flow in the monkey brain.


Diffuse head cooling as a method for producing a gradient of brain hypothermia and decreased blood volume.


Regional cerebral blood flow and increased intracranial pressure produced by simulated hydrocephalus, mass lesion, and cerebraal edema.


Arterial pCO 2  reduction in the treatment of acute increased intracranial pressure.


Intercosto-sacral neural anastomosis.

Intercosto-sacral neural anastomosis.


The time facctor in antibiotic prophylaxis of penetrating wounds of the abdomen.


The hydrolysis of synkavite by prostatic acid phosphatase.


Hypophosphatemia with hypophosphaturia in hyperalimentation.


Beneficial effects of immediate postoperative total parenteral nutrition.


Fat and carbohydrate metabolism during hemorrhagic shock in the unanesthetized baboon.


Planning for national health care delivery.


Serum lactic dehydrogenase and other enzymes in malignant disease. Comparison with an immunodiagnostic test for cancer.


Plasma alkaline phosphatase isozymes: isolation and characterization of isozymes.


The effect of glucose on the glomerular filtration rate in normal man. A preliminary report.


Ascaris cuticle collagen: on the antigenic specificity of the subunits.


Rat enterokinase: the effect of ions and the localization in the intestine.


Purification and biochemical characteristics of urease from Proteus rettgeri.


Methylation of arginine and lysine residues of cerebral proteins.


Toxicologic studies of the 2,4-diamino-quinazoline antifolate, methasquin (NSC-122870).


Leukemia L1210 therapy trials with antileukemia serum and Bacillus Calmette-Guérin.


Serum and urinary protein alterations in C57BL-10 lymphoma-bearing mice.


Demonstration in serum of two physiological forms of the human retinol binding protein.


Effects of prostaglandin on blood flow in the rabbit eye.


Further studies on the effect of prostaglandin on intraocular pressure in the rabbit.


Aqueous humor dynamics in monkeys (Macaca irus and Cercopithecus ethiops).


Further studies on ticks of wild monkeys of Kyasanur Forest Disease area Shimoga District.


The hydrational effect of alkaline-earth chlorides and selected non-electrolytes on the Rh-anti-Rh system.


Experimental neurolathyrism in monkeys.

Experimental neurolathyrism in monkeys.


Unusual structures of specific periodicity in the midgut of aged drosophila melanogaster.


Correlations between amino acid sequence and conformation of immunoglobulin light chains. I. Hydrophobicity and fractional charge.


The removal and restoration of stimulus control. When a well-learned circle versus ellipse discrimination was made impossibly difficult for the subjects (rhesus monkeys), the controlling stimulus-response topographies were replaced by competing topographies. The identification of two training conditions sufficient to reinstate the original discrimination permitted the following inferences: the original controlling topography had merely decreased in probability of occurrence, whereas the "strength" of the stimulus-response relation remained unchanged; discriminations along the apparently continuous circle-ellipse dimension actually involved several distinct stimulus-control topographies.


Ultrastructural localization of a soluble collagen antigen.


Drug activity against trematodes.

Drug activity against trematodes.


The mechanisms of drug resistance in malaria parasites.


Behavioral temperature regulation in the squirrel monkey: effects of midbrain temperature displacements.


Behavioral temperature regulation in Cynomolgus and pig-tailed macaques.


Impulse coding in primate cutaneous thermoreceptors in dynamic thermal conditions.


Eco-physiological patterns of thermoregulation and the shivering thermogenesis.


The relation between behavior and physiology in the thermoregulatory response of the squirrel moneky.


Present trends in the laboratory diagnosis of N. gonorrhoeae.


Hypertonic parenteral alimentation in infants and children.


The role of disodium cromoglycate in its treatment.


Centrencephalic myoclonic-astatic petit mal. Clinical and genetic investigation.


Further experience with Forrest tests in obstetrics.


A technique of tubeless gastrostomy for use in newborn and small animals.


Levodopa.

Levodopa.


Osteomyelitis in heroin addicts.

Osteomyelitis in heroin addicts.


Some properties of the phage of the Corynebacterium diphtheriae Park Williams No. 8 strain.


Biological and antigenic analyses of newly isolated strains of Echovirus type 7.


The binding of cholic acid and its taurine conjugate to serum proteins.


Chemical measurements of serum hormonal iodine.


Ss protein: search for cross-reacting substances in different species.


Induction of mutations by the indirect effect of ionizing radiation in oocytes of Drosophila melanogaster.


Aerobic microbes isolated from slaughtered pigs and their public health importance.


Sterility control.

Sterility control.


Thermophilic aminopeptidases from Bacillus stearothermophilus. I. Isolation, specificity, and general properties of the thermostable aminopeptidase I.