Detection of a beta-lactamase markedly active against carbenicillin in a strain of Pseudomonas aeruginosa. Examination of the substrate profile of a number of beta-lactamases synthesized by strains of Pseudomonas aeruginosa has shown the presence of at least two distinct types of enzyme, one of which is more active against carbenicillin than against benzyl penicillin.


Resistance of Escherichia coli to penicillins. 8. Physiology of a class II ampicillin-resistant mutant. Class II ampicillin-resistant mutants of Escherichia coli are defined as having a twofold increase in penicillinase-mediated ampicillin resistance when determined by colony formation tests on plates. In this paper, one class II mutant has been compared to its parent strain. In liquid medium, the mutant was less resistant than the parent strain both in the absence and in the presence of R1 and R-factor mediating penicillinase activity. The penicillinase activity was found to be almost completely bound to the cells in the parent strain, whereas it was excreted to a great extent in the class II mutant strain. In liquid medium, resistance was well correlated to the cell-bound penicillinase activity, whereas the excreted penicillinases were also of great importance for survival on ampicillin plates. The mutant also had a changed resistance to a great number of other antibacterial drugs. The mutant was found to be more sensitive than the parent strain to osmotic shock, especially when treated with ethylenediaminetetraacetic acid or washed with sodium ions. However, the osmotic stability was restored by the presence of 1 mm Mg(2+) ions. The class II mutant was more sensitive than the parent strain to sodium cholate, and it adsorbed the phages T4 and T3-1 at a slower rate than did the parent strain. The two strains adsorbed T6 at the same rate. The class II phenotype could be gradually reversed by increasing concentrations of divalent cations. The pleiotropic changes in the phenotype are apparently unrelated to the specific targets for the antibacterial agents tested. They are secondary consequences of a cell envelope mutation. The findings indicate that the class II mutation mediates a structural change in the lipopolysaccharide of the cell envelope.


Comparative allostery of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthetase as a molecular basis for classification. The allosteric pattern of control for 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAHP) synthetase has previously been shown to be strongly conserved among the member species of a given genus in bacteria. The implications of this finding as a procedural tool of bacterial phylogeny were pursued by a study of two organisms, Sporosarcina ureae and Aeromonas formicans, the taxonomic positions of which have been historically controversial. S. ureae has characteristics of both Bacillaceae and Micrococcaceae, and A. formicans has characteristics of both Enterobacteriaceae and pseudomonads. Since the patterns of control for DAHP synthetase in all four of these microbial groups are different from one another but internally homogeneous within each group, the results obtained from the two test organisms were unambiguous. It was concluded that S. ureae is properly classified within Bacillaceae, probably deserving generic rank, and that A. formicans belongs with the family Enterobacteriaceae.


Quantitive autoradiographic study of competence and deoxyribonucleic acid incorporation in Bacillus subtilis. The relationships among deoxyribonucleic acid (DNA) uptake, transformation, and autoradiographic labeling were investigated. It is shown that: (i) autoradiography is a good method for measuring the total fraction of competent cells able to incorporate transforming DNA; in our best experiment that fraction was 11.5%. (ii) Computation of the fraction of competent cells in a culture of Bacillus subtilis, by comparing the frequencies of single and double transformants for two unlinked markers, gives values which are somewhat different from those obtained by auto-radiography. (iii) On the average, a competent cell of B. subtilis irreversibly takes up from 0.9 x 10(-10) to 1.4 x 10(-10) mug of DNA; this amount represents about 1/55 to 1/35 of the bacterial chromosome weighing 5 x 10(-9) mug, and corresponds to three to six DNA molecules having a molecular weight of 1.6 x 10(7).


Isolation of mutants of Staphylococcus aureus lacking extracellular nuclease activity. Suspensions of Staphylococcus aureus Foggi strain were exposed to nitrosoguanidine and screened on deoxyribonucleic acid-acridine orange-agar plates for loss of extracellular nuclease activity. All nuclease-deficient mutants lacked cross-reacting material when tested with antinuclease antibody. Coagulase and beta-hemolysin were also lost in nuclease-deficient mutants, and all three enzyme functions were regained together upon reversion with ethyl methane sulfonate. These observations are consistent with the suggestion that the synthesis or the release, or both the synthesis and release, of certain extracellular enzymes may be subject to coordinated control mechanisms.


The use of pronase in tissue culture: a comparison with trypsin.


Some observations on the circulation of phenosulfonpthalein in cerebrospinal fluid: normal flow and the flow in hydrocephalus.


Serological relationship of the Tacaribe complex of viruses to lymphocytic choriomeningitis virus. By means of the indirect fluorescent-antibody test, cross serological reactivity was demonstrated between lymphocytic choriomeningitis (LCM) virus and the viruses of the Tacaribe complex. Antisera to all members of the Tacaribe complex reacted with LCM virus; LCM antisera gave significant staining of Amapari virus, but minimal or inconsistent reactions with Tacaribe virus, and no reaction with two other viruses of the Tacaribe complex. A low level cross-reaction was observed in complement fixation tests of Machupo and Pichinde antisera against LCM antigen. Immunization with Tacaribe and Amapari viruses did not protect mice against challenge with LCM virus. Because of the identical appearance of the virions, the sharing of antigens, and the many biological similarities between LCM and the Tacaribe complex viruses, it is proposed that they be considered as constituting a new taxonomic group of viruses.


Programme for the care of mentally subnormal children and disturbed children.


Estriol excretion with erythroblastosis.


Pulp capping in deciduous and newly erupted permanent teeth of monkeys.


Microcirculation of the perioral regions in the Macaca rhesus. I.


Placental clearance and fetal oxygenation.


Juvenile migraine, presenting as an acute confusional state.


Monkey-hand wringer injury. An experimental study.


Depression and stimulation of host defense mechanisms after severe burns.


Optimum physical performance capacity in adults: Report of a WHO Scientific Group.


Active vasodilatation evoked by stimulation of sinus nerves in the conscious dog.


The release of 5S RNA from reticulocyte ribosomes.


Energy dependent changes in the oxidation-reduction potential of cytochrome b.


Isolation and characterization of uridine diphosphate-N-glycolylmuramyl-L-alanyl-gamma-D-glutamyl-meso-alpha,alpha'-diaminopimelic acid from Mycobacterium tuberculosis.


Oxidation processes in relation to the induction of enzymes in Jerusalem artichoke tuber slices.


Techniques for the demonstration of myoglobin in biological materials.


Physicochemical and kinetic properties of mushroom tyrosinase.


Histidine regulation in Salmonella typhimurium. VII. Purification and general properties of the histidyl transfer ribonucleic acid synthetase.


Threonine deaminase from Bacillus subtilis. I. Purification of the enzyme.


Threonine deaminase from Bacillus subtilis. II. The steady state kinetic properties.


Threonine deaminase from Bacillus subtilis. 3. Pre-steady state kinetic properties.


Diagnostic significance of scalp and depth EEG findings in patients with temporal and frontal lobe epilepsy.


The case against heroic hyperalimentation.


Cybernetic concepts in population dynamics.


Possibilities and limitations of functional analysis of circadian rhythms.


Periodic oviposition in the freshwater snail Lymnaea stagnalis: a new type of endogenous rhythm.


The cytologic diagnosis of transitional cell tumors of the urinary bladder and its histologic basis. A study of 567 cases of urinary-tract disorder including 170 untreated and 182 irradiated bladder tumors.


Right aortic arch with aberrant left subclavian artery and aneurysm of right subclavian artery. Report of a case.


Biliary duct cysts.

Biliary duct cysts.


Inomycin a new antibiotic of the cycloheximide group. II. Isolation and characterization of the antibiotic.


Mechanism of decreased venous return. Subhuman primate-administered endotoxin.


Enteroliths and perforation of duodenal diverticula.


Active immunization of dogs with a non virulent strain of Trypanosoma cruzi.


The effect of oral treatment with prednisone on T. cruzi parasitemia of patients with chronic Chagas' heart disease.


Salmonella surveillance in Czechoslovakia. IV. The occurrence of salmonella serotypes in veterinary material in the year 1965.


Investigation and appplication of the USSR AMS live measles vaccine from the ESC strain for mass vaccination against measles.


Participation of nonspecific factors in the destruction of type M 12 streptococcus in vitro. I. Nonspecific absorption of anti-M 12 bactericidal activity.


Studies on the invitro formation of monoiodotyrosine by soluble supernatant of pigeon thyroid gland.


Traumatic pseudodiverticulum of the esophagus in the newborn infant.


Action of mutagenic chemicals on Anacystis nidulans. IV. Acridine dyes.


Loss of calcium from Azotobacter cysts.

Loss of calcium from Azotobacter cysts.


Early Paget's disease of the labyrinthine capsule. Case report and bone study.


Partial purification and characterization of an acid dipeptide naphthylamidase (carboxytripeptidase) of the rat skin.


Partial purification and characterization of an alkaline dipeptide naphthylamidase (Arg-Arg-NAase) of the rat skin.


Experimental cholesterol granuloma.

Experimental cholesterol granuloma.


Studies on antigenic and catalytic sites of the semen acid phosphatase.


The prevention of coronary arteriosclerotic heart disease with chondroitin sulfate A: preliminary report.


Solution of the Rh-Hr nomenclature problem.


A comparative study of the activity patterns and behavior of Alouatta villosa and Ateles geoffroyi.


Reproductive cycles of the mangabey Cercocebus albigena.


Defective infants in a feral monkey group.


The effects of sterigmatocystin on a primary cell culture.


Determination of integral doses in a non-homogeneous medium.


Serologic surveys of human cancer patients for antibody to adenovirus T antigens.


The serum hepatitis related antigen (SH) in illicit drug users.


Immunochemical methods for detection and quantitation of Kunitz soybean trypsin inhibitor.


Subsite mapping of enzymes. Studies on Bacillus subtilis amylase.


Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver.


Edetic acid therapy.

Edetic acid therapy.


The controlled dissociation of proteins from rat liver ribosomes by potassium chloride.


Chemoprophylaxis in large bowel surgery. 2. In vitro study of penicillin on penicillin-resistant organisms.


Similarity of cardiac CR forms in the rhesus monkey during several experimental procedures.


LDH isoenzymes in serum, urine and amniotic fluid in Rh-immunization and in normal pregnancy.


Experiences with intrauterine blood transfusions.


The ratio between the skin temperature and the acid-base balance of the newborn during the first munutes of life.


Isoenzymes of bacterial beta-galactosidases: purification and characterization of a nonisoenzyme forming beta-galactosidase of Aerobacter cloacae.


The isoenzymes of human parotid amylase.


Retinopathy in primary macroglobulinaemia.


Blood dyscrasias and central retinal vein occlusion.


A mathematical model for bladder neck function.


Firing patterns of abducens neurons of alert monkeys in relationship to horizontal eye movement.


Oculomotor unit behavior in the monkey.

Oculomotor unit behavior in the monkey.


Out of sight, out of mind.

Out of sight, out of mind.


Regulation of cholesterol metabolism. I.


Immunological distinction between fraction I protein and protochlorophyllide holochrome.


Electron-beam technique and skin reaction of postoperative irradiation of axilla and supraclavicular nodes in breast carcinoma.


The evolution of photosynthesis.

The evolution of photosynthesis.


Inactivation of human serum plasminogen antiactivator by synthetic fibrinolysis inducers.


The activity of some hydrolytic enzymes in mesencephalic trigeminal neurons of developing rat.


Immunohistochemical identification of amyloid deposits.


Prevention of glycogen polarization and other morphological changes in rat liver cells by increased solute concentration during formaldehyde fixation. A light and electron microscopic study.


Histochemical detection of unmyelinated terminals of autonomic nervous ramification on paraffin sections.


The effect of MSI on the activity of acid phosphatases.


Precipitation and counting of minute quantities of labeled nucleic acids as cetyltrimethylammonium salt.


Purification and characterization of alpha 1-acid glycoprotein from ascitic fluid.


Purification and properties of laccase and stellacyanin from Rhus vernicifera.


Proteins released from chick embryo fibroblasts in culture. I. Partial characterization of the proteins.


Vigilance, the psychological refractory period, and brain stem multiple-unit activity.


Projections from the body of the caudate nucleus in the rhesus monkey.


Nystagmus evoked by utricular stimulation.


Properties of a blue-green algal sheath.


Distribution and elimination of exogenous alpha1-antitrypsin.


Characterization of ovine hypothalamic hypophysiotropic TSH-releasing factor.


Recoverable temperature-sensing implant. SAM-TR-69-69.


The occipital emissary channel and increased intracranial pressure.


Proportion of tubercle bacilli resistant to drugs in an isolate.


Public health evaluation of active cases of tuberculosis.


Interdivisional nuclear changes. Microphotometric studies on DNA synthesis in Chilodonella cucullulus (O. F. Müller).


The interaction of hormones and blood proteins. A nephelometric method for the estimation of the binding power of thyroxine to blood proteins.


Interactions of hormones and blood proteins. In vitro effect of thyroid--influencing drugs upon the binding of thyroxine to plasma proteins.


Erythropoietin release in renal allografted baboons, with and without immunosuppression.


Erythropoietin alterations in the presence of dimethylnitrosamine liver injury in canine and simian species.


Acute renal and systemic effects after experimental coarctation of the aorta in the baboon.


Fatigue fracture of the tarsal navicular.


Bowler's thumb. Perineural fibrosis of the digital nerve.


Inhibition of pancreatic lipase by tetracyclines.


Diester waxes in surface lipids of animal skin.


A bacteriological study of strains of Corynebacterium diphtheriae isolated in Victoria and New South Wales.


Bacterial hydrocarbons: occurrence, structure and metabolism.


Pathogenesis of scrapie in the mouse: the role of the spleen.


Interferon required for viral resistance induced by poly I.poly C.


Assessment of Rh disease by ratios of bilirubin to albumin and hemopexin to albumin in amniotic fluid.


Regulation of cholesterol metabolism.

Regulation of cholesterol metabolism.


Evaluation of fetal hemolysis.

Evaluation of fetal hemolysis.


Meningococcal meningitis: repeat case.

Meningococcal meningitis: repeat case.


Comparative studies of blood and uterus calcium levels, alkaline phosphatase and carbonic anhydrase activities in White Leghorn and White Plymouth Rock hens, in relation to shell quality and production rate.


Radiation effects on the eye.

Radiation effects on the eye.


In vitro and in vivo studies of streptomycin-dependent cholera vibrios. Streptomycin-dependent cholera vibrio strains were derived from Inaba, Ogawa, and NAG vibrios by the method of Mel. These phenotypes grew more slowly and attacked fermentable substances after a longer period of time than the streptomycin-sensitive parent strains. Rabbits injected with streptomycin-sensitive strains and their streptomycin-dependent forms showed homologous agglutinin production. Patas monkeys fed with 10(9) streptomycin-dependent strains shed them for 1 to 2 days without ill effect, whereas the same number of streptomycin-independent organisms caused disease. The possibility of the application of multiple doses of streptomycin-dependent organisms in oral immunization against cholera was considered.


Influence of pH and aeration on bacterial formation of amylase. Amylase production by a Bacillus subtilis strain can occur without aeration after reaching the stationary phase of growth, provided the pH is controlled.


New antibacterial agent isolated from the avocado pear. A group of eight new long-chain aliphatic compounds recently isolated from the avocado and some derivatives thereof were tested for antibacterial activity on 13 different species of bacteria and a yeast. Some of these compounds inhibited the growth of microorganisms. 1,2,4-Trihydroxy-n-hepadeca-16-en was found to be the most active, inhibiting certain gram-positive bacteria at 4 mug/ml.


Adaptation of a roller-tube apparatus to accommodate cultivation of cells in roller-bottles. We have adapted the standard roller-tube apparatus to production of large scale cell culture by modifying the drum to accept bottles.


Use of Vero cells for titration of rinderpest virus and its neutralizing antibody. Primary bovine embryonic kidney cell was successfully replaced by the green monkey cell line (Vero) for the isolation and seroneutralization of rinderpest virus.


Continuous monitoring of oxygen concentrations in air-purged shake-flask fermentations. Continuous monitoring of the oxygen concentrations in the gas and liquid phases in air-purged shake-flask fermentations was accomplished by means of steam-sterilizable oxygen probes.


Suction drainage. A study in wound healing.


Primary immunization of Rh-negative volunteers. To determine the best method for the production of high-titre anti-D serum primary immunization was carried out in two groups of Rh-negative male volunteers with washed group O R(2)R(2) cells. The first group of six men were given 5 ml. of packed cells, and the second group of five men were given 0.5 ml. of packed cells, in each instance by intravenous injection. Only one individual in each group failed to develop anti-D following the primary inoculation, and it has been concluded that 0.5 ml. of packed R(2)R(2) cells is probably a satisfactory dose for this purpose.There was a delay of several weeks before anti-D could be shown to have developed. The initial antibodies which appeared in the serum comprised 7S gammaG immunoglobulins, with, in about half the cases, a minor 19S gammaM component.


Electrochemical determination of apparent ionized serum calcium using a calcium-selective electrode: the method and values in normal humans and a comparison to total serum calcium.


Antibacterial activity of resperin vapours.


The mechanism of mycobacterial resistance to penicillins and cephalosporins.


Drug resistance in M. tuberculosis cultures determined by the Steenken MIC and Canetti proportion tests.


Intercomparison of high energy electrons and x-rays in Japan by use of Fricke dosimeter.


The effective molecular titration of the early components of dog complement.


Prostaglandins: the inhibition of hepatic cholesterol ester synthesase in the rat.


A technique for immunoassay of human IgG.


Interactions between endotoxic lipopolysaccharides and the complement system in the sera of lower vertebrates.


Nuclear inclusions observed by electron microscope in Cynomolgus monkey kidney cells infected with influenza virus.


Characterization of Mount Elgon bat virus, a new member of the rhabdovirus group.


Improving the agar-diffusion method for assaying aminosidine, neomycin, and streptomycin.


Effect of Peruvosid (CD412) on excitability and functional refractory period of atrial and ventricular tissues in cardiomyopathy caused by Trypanosoma cruzi. Attempts were made to produce myocarditis by Trypanosoma cruzi inoculation in healthy dog puppies 6 to 8 weeks old. Significant electrocardiographic abnormalities were produced, coinciding with interstitial inflammatory processes in the cardiac tissue and with degenerative changes in the myocardial fibres. In puppies showing these changes, profound changes in the excitability and the functional refractory period of the atrial and ventricular muscular tissue were observed. The administration of Peruvosid in doses of 0.0240 to 0.0647 mg./kg. tended to diminish the excitability, previously increased by the inflammatory process, at the same time increasing the functional refractory period duration which had previously been shortened. The fact that Peruvosid corrects these fundamental factors in the genesis of cardiac arrhythmias suggests that the drug may be useful in the treatment of cardiac insufficiency produced by Chagas' myocardiopathy, in which arrhythmias are one of the basic characteristics.


Pathology of cardiomyopathy from South India. Seven cases of cardiomyopathy are presented with detailed macroscopical and microscopical studies. There are some differences and also similarities between this group and those described by Davies from Uganda. Myocytolysis was present in all cases, and appeared earlier than endocarditis. The earliest endocardial lesion was smooth muscle hyperplasia. Feeding of monkeys with plantains for more than 8 months failed to produce any changes in the heart.


Bronchogenic carcinoma in a 14-year-old boy.


Carcinoma in a pharyngeal diverticulum.

Carcinoma in a pharyngeal diverticulum.


Evaluation of Thyopac-3 test in the in-vitro assessment of thyroid function. Thyopac-3, a new commercial test kit for the in-vitro assessment of thyroid function, has been appraised in a group of 411 patients. The Thyopac-3 test was found to be simple and rapid to perform and accurate in diagnosis. Of 117 patients shown to be euthyroid by other criteria, 5% had Thyopac-3 values outside the normal range (derived from a group of 135 normal patients), and 10 of 79 thyrotoxic and 4 of 37 hypothyroid patients had values within the normal range.In a direct comparison in 190 patients with the resin uptake test the Thyopac-3 test emerged very favourably in regard to diagnostic accuracy and was technically easier and quicker to carry out. There was a non-linear negative correlation between results from the two procedures.


Raised serum IgG levels in hypertension. Serum IgG levels were significantly higher in 118 severely hypertensive patients compared with a group of 163 normotensive blood donors, matched for age and sex. Serum IgA and IgM were the same in both groups. Raised levels of serum IgG were found in patients who had never been treated for hypertension, as well as in those who were treated with methyldopa or other hypotensive drugs.It is suggested that the raised levels of serum IgG may be an index of vascular damage induced by hypertension.


Isolation, purification and physico-chemical characteristic of Shigella sonnei phase I free endotoxin.


The social worker in the long-term care facility.


Outpatient group psychotherapy with sex offenders.


An attempt to examine the perception of self and hospital among chronically ill mental patients.


Immunofluorescent localization of ornithine aminotransferase in rat liver.


Beta-hexosaminidases in the nervous system: the quantitative histochemistry of beta-glucosaminidase and beta-galactosaminidase in the cerebellar cortex and subjacent white matter.


Whole body measurements of 131-I-tetracycline as an index of skeletal growth.


Synthesis and antibacterial activity of 1-styryl-3,4-dihydroisoquinolines.


Laparo-uterotomy in squirrel monkey (Saimiri sciureus).


The lexan calvarium for the study of cerebral responses to acute trauma.


DNA replication in mammalian cells. I. The size of newly synthesized helices. The newly synthesized DNA of heteroploid human cells cultured in vitro has a single-stranded molecular weight of approximately 1 x 10(5) following 30- to 60-second pulses of labeling with tritiated thymidine. With increasing pulse times the amount of radioactive DNA having a low single-stranded molecular weight remains approximately constant, whereas increasing amounts of label are found associated with the bulk DNA. After removing the label from the medium, the radioactivity associated with the small molecular weight DNA is chased into high molecular weight material. These findings are analogous to what is observed in microorganisms and suggest a basically common organization of the growing point of DNA in bacterial and in mammalian cells.


Doxynucleotide-polymerizing enzymes of calf thymus gland. IV. Inhibition of terminal deoxynucleotidyl transferase by metal ligands. The polymerization of deoxynucleoside triphosphates, catalyzed by terminal deoxynucleotidyl transferase from calf thymus gland, is strongly inhibited by various metal chelators. The reaction appears to be first order with respect to enzyme, deoxynucleoside triphosphate, and initiator, indicating that there is only one catalytic center for each enzyme molecule. The presence of metal chelator does not affect the molecular state of the enzyme or the order of reaction. An analysis of the kinetics of o-phenanthroline inhibition demonstrates that the ligand is noncompetitive with nucleoside triphosphate substrate and strictly competitive with oligodeoxynucleotide initiator. These results, obtained in the presence of millimolar Mg(++), suggest that the initiator binds to the enzyme through a transition metal atom and ligand inhibition occurs at that site. The precise spatial arrangement of the coordination orbitals around a metal atom provides a model to visualize the specificity of the enzyme for the 3'-OH end of the growing polynucleotide chain.


Template properties of complementary fractions of denatured microbial deoxyribonucleic acids. DNA preparations from seven bacterial species and from E. coli phage T4, and also the complementary L and H fractions into which these DNA specimens, after denaturation, were separated by chromatography on methylated albumin-kieselguhr columns, were studied as templates in the RNA polymerase system, and the nucleotide composition of the RNA products was determined. The RNA transcripts of the separated L and H fractions were found to be faithful copies of the respective DNA fractions. This suggests "transcription analysis" as a sensitive and reliable analytical technique for the determination of the base composition of denatured DNA. The L and H fractions of T4 DNA were shown, both by temperature-absorbance profiles and by transcription analysis, to be mutually complementary. The RNA products formed with intact DNA as the template were not exact copies of the latter; their composition indicated that under our experimental conditions the "heavy" DNA strand is transcribed preferentially.


Aspects of suxamethonium hydrolysis in man and animals.


Spinal cord angiography.

Spinal cord angiography.


Biliary tract obstruction and duodenal diverticula.


The ribosome dissociation factor and the ribosome-polysome cycle.


Gamma-phosphoryl ester of glu-tRNA-GLN as an intermediate in Bacillus subtilis glutaminyl-tRNA synthesis.


Ribosomal proteins of E. Coli: stoichiometry and implications for ribosome structure.


Characterization of messenger RNA for hemoglobin.


DNA-dependent in vitro synthesis of bacteriophage enzymes.


Giant retinal tears. II. Experimental production and management with intravitreal air.


The genetics of ribosomes in Bacillus subtilis.


Late ocular syphilis: transfer of infection from man to experimental animals.


Fluid compartment alterations in the monkey with staphylococcic B enterotoxemia.


X-chromosomal-linked diseases affecting the eye: status of the heterozygote female.


Treatment of eruptive xanthomas in Cori type I glycogenosis.


Dental Medicaid (Title XIX) implemented in Arkansas.


The interdental stimulator--its use and abuse.


The practice of dental hygiene: a privilege implying attendant responsibilities.


School of Dental Hygiene. Director's report.


Glutaminase from pig renal cortex. I. Purification and general properties.


Modification of the single tryptophan residue of staphylococcal nuclease by a new mild oxidizing agent.


Studies on the protein-protein and protein-ligand interactions involved in retinol transport in plasma.


Solubilization and partial purification of cellulose synthetase from Phaseolus aureus.


The amino-terminal residues of Bacillus subtilis proteins made in vitro.


Natural precipitating proteins in insect haemolymph.


Changing pattern in communicable diseases and reappraisal of the communicable disease prevention.


Amygdalectomy in the free-ranging vervet (Cercopithecus aethiops).


Biology of the mycobacterioses. Distinct circulating antibodies demonstrated in tuberculous patients, correlation between changes in the antibody content of the serum, and clinical evolution.


Ion-exchange separation and automated assay of complex mixtures of amino acids and hexosamines.


Biology of the mycobacterioses. Pathogenesis of tuberculosis in man.


Biology of the mycobacterioses. The macrophage-tubercle bacillus relationship and resistance to tuberculosis.


Biology of the mycobacterioses. Experimental models for study of immunity in tuberculosis.


Biology of the mycobacterioses. Simian tuberculosis: immunologic aspects.


Biology of the mycobacterioses. Statement of questions.


Biology of the mycobacterioses. Structure and biological functions of mycobacteria.


Haptoglobin determinations in the study of hemolytic anemia.


Biology of the mycobacterioses. Chemical and immunological studies on peptides and polysaccharides from tubercle bacilli.


Biology of the mycobacterioses. Metabolism of in vivo grown mycobacteria.


Morphologic adaptations secondary to the production of experimental cleft palate in primates.


Heterogeneity of erythrocyte glucose-6-phosphate dehydrogenase (G6PD, E.C. 1.1.1.49) activity and electrophoretic patterns among representatives of different classes of vertebrates.


The effect of growth inhibitors on postembryonic development in the free-living nematode, Pangrellus silusiae.


Life with a transplanted kidney.

Life with a transplanted kidney.


Effect of ethylenediamine tetraacetic acid on penicillinase inducibility in Staphylococcus aureus.


Ribosomes from spores of Bacillus cereus T. Data from analytical ultracentrifuge studies suggest that polymers of ribosomes exist in dormant spores of Bacillus cereus T.


Clinical studies with tubercidin administered after absorption into human erythrocytes.


The mitogenic activity of a C57BL-10 mouse transplantable lyhoma.


Transplantable thyroid tumors in the rat: development of normal-appearing thyroid follicles in the differentiated tumors, and development of differentiated tumors from iodine-deficient, thyroxine-involuted goiters.


D-norgestrel combined with ethinyl oestradiol as an oral contraceptive.


Doxepin in the treatment of psychoneurotic patients.


A comparison of doxepin and chlordiazepoxide in the therapy of anxiety.


Doxepin versus chlordiazepoxide: a double-blind study on anxious outpatients.


A comparative evaluation of doxepin and chlordiazepoxide in the treatment of psychoneurotic outpatients.


CI-601, a butyrophenone derivative, in the treatment of chronically withdrawn schizophrenic patients.


A controlled study of the effects of gamfexine in phenothiazine-treated patients.


Treatment of severe generalized psoriasis with oral methotrexate. (A case report).


Further study of the effect of dextran on experimental hyperlipemia in rabbits.


Clinical neuropathological conference.

Clinical neuropathological conference.


An improved procedure for thin-layer and column chromatography of xanthones on silica gel.


Serologic evidence of Rickettsia canada infection of man.


Cutaneous reactions and antibody response to meningococcal group C polysaccharide vaccines in man.


Specificity of immunoglobulin G in rhesus monkeys infected with Schistosoma mansoni, Plasmodium knowlesi, and Trypanosoma brucei.


Persistent viruria due to reovirus in a patient treated for Hodgkin's disease in a protected environment.


Revival of antibacterial immunization: meningococcal vaccines prove promising.


News from the Federal Trade Commission.

News from the Federal Trade Commission.


Synthetic schistosomicides. XVI. 5-(mono- and dialkylamino)-2-nitrosophenols, 2-amino-5-(dialkylamino)phenols, and related compounds.


Preparation and activity of the 4'-thio derivatives of some 6-substituted purine nucleosides.


Rat liver glutamate formiminotransferase activity in B12 deprivation and germfree conditions.


Protein deficiency and liver injury.

Protein deficiency and liver injury.


Nucleoplasmic ribonucleoprotein particles of rat liver. I. Selective degradation by nuclear nucleases.


Increased urinary excretion of chondroitin sulfate A and C in Hunter's syndrome.


Studies of (3H)folic acid uptake by Lactobacillus casei.


Interaction of environmental agents and drugs.


Difficulties in extrapolating the results of toxicity studies in laboratory animals to man.


Blood group isoantigen receptors of human fetal epidermal cells.


Kanamycin as treatment of acute gonorrhea in females.


Locomotor delayed response in frontally ablated monkeys.


Impairments on locomotor task involving spatial opposition between cue and reward in frontally ablated monkeys.


Histochemical observations concerning the transport of lipids into the developing oocyte of primates.


Experimental retinal branch vein occlusion.


The carbonic anhydrases of some guinea-pig tissues.


Studies on isozymes of fructose-1,6-diphosphate aldolase during amphibian development. II. Characterization of isozymes in the egg of Rana pipiens.


In vivo studies on histamine catabolism and its inhibition. 1. Histamine catabolism in vivo was studied in mice subjected to various forms of pretreatment; tissues from mice killed 2.5 min after intravenous injection of (14)C-histamine were assayed for (14)C-histamine, (14)C-methylhistamine and total (14)C.2. Pretreatment of mice with aminoguanidine, an inhibitor of diamine oxidase, strongly increased levels of (14)C-histamine in intestine; pretreatment with aminoguanidine plus a monoamine oxidase inhibitor strongly increased levels of (14)C-methylhistamine in liver. Effects in other tissues are reported and discussed.3. Pretreatment of mice with non-isotopic methylhistamine increased levels of (14)C-histamine in liver. Methylhistamine is the first known inhibitor of histamine-methylation in vivo.4. Pretreatment of mice with inhibitors of protein synthesis, drugs which reduce the basal activity of histidine decarboxylase and which block its activation, failed to affect histamine catabolism.5. Pretreatment of mice with endotoxin or with Freund's adjuvant, irritants known to cause activation of histidine decarboxylase, failed to affect histamine catabolism.6. There was no evidence of parallelism between the histamine-destroying enzymes and the histamine-forming enzyme, histidine decarboxylase, either in distribution or ability to undergo changes in activity. No support was obtained for the view that histamine-catabolizing enzymes play a role in the local control of responses to newly formed histamine.


Neural coding in the sense of touch: human sensations of skin indentation compared with the responses of slowly adapting mechanoreceptive afferents innvervating the hairy skin of monkeys.


Topography of the retina and striate cortex and its relationship to visual acuity in rhesus monkeys and squirrel monkeys.


Tissue of hyaline cartilage in the relief image under the light and electron microscope.


Phylogenetic differences in pattern and composition of dorsal finger aponeurosis.


Immunochemical studies on bovine trypsin and trypsinogen derivatives.


Further studies on single radial immunodiffusion. IV. Quantitation of heterologous antigens by means of cross-reacting antisera.


Interaction of concanavalin A with polysaccharides of Salmonellae.


Effect of reduction upon the PCA-blocking activity of immunoglobulin E.


Hormones and reproductive behaviour in rheusus and talapoin monkeys.


Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects. Studies of the possibility that thyroxine (T4) is converted to 3.5,3'-triiodo-L-thyronine (T3) in the extrathyroidal tissues in man have been conducted in 13 patients, all but two of whom were athyreotic or hypothyroid, and all of whom were receiving at least physiological replacement doses of synthetic sodium-L-thyroxine.T3 was found in the sera of all patients, in concentrations ranging between 243 and 680 ng/100 ml (normal range 170-270 ng/100 ml). These concentrations were far in excess of those which would have been expected on the basis of the T3 contamination of the administered T4, as measured by the same technique employed in the analysis of serum. When oral medication was enriched with (125)I-labeled T4 for 8 or more days, labeled T3 and tetraiodothyroacetic acid (Tetrac or TA(4)) were found in the serum to the extent of approximately 2-5% of total radioactivity, as assessed by unidimensional paper chromatography. The same results were obtained with a specially purified lot of radioactive T4 containing less than 0.1% T3 as a contaminant. The identities of the (125)I-labeled T3 and TA(4) were verified by two-dimensional chromatography as well as by specific patterns of binding in serum. The labeled T3 isolated was bound by albumin and by T4-binding globulin (TBG), but not by T4-binding prealbumin (TBPA): in contrast the labeled TA(4) was bound by albumin and TBPA, but not by TBG. To exclude the possibility that the conversion of T4 to T3 was a peculiarity of the oral route of administration, the sera of two additional patients were obtained 48 hr after 7-day courses of daily intravenous injections of a mixture of stable and (125)I-labeled T4. Both stable and labeled T3 were likewise found in these sera. In contrast to earlier experiments in humans in which (131)I-labeled T3 was not definitively demonstrated in serum after a single intravenous injection of (131)I-labeled T4, the present findings are taken to provide conclusive evidence of the extrathyroidal conversion of T4 to T3 in man. These results raise once again the question of the extent to which the metabolic effect of T4 is mediated through the peripheral generation of T3.


Vital statistics and census tract data used to evaluate family planning. In an estimated total eligible population of 50,000 disadvantaged women, mostly nonwhite, living in Fulton and DeKalb Counties, Georgia, 12,000 to 15,000 were new contraceptive patients in a postpartum clinic at Grady Memorial Hospital in the  Emory University Family Planning Program from September 1962 to the end of 1966.  Attempts to determine whether the Program influenced the birth rate, especially among nonwhites (90% of the new clients), were made using vital statistics and census tract data.  For Fulton County, which included 80-95% of the eligible population, crude birth rates for whites and nonwhites declined yearly at an average 2.8% and 3.9%, respectively, for 1960-1967.  The greatest yearly declines were in 1965-1967.  Oral contraceptives and the IUD were introduced in the Program in mid-1963 and late 1964, respectively.  The decline of the white birth rate is due in part to the aging of the white population of Fulton County resulting mainly from the exodus of its younger members to suburban counties.  Since among nonwhites both emigration from Atlanta to the north and immigration to the Atlanta area from rural southern areas occurred, it is unlikely that the age composition of the nonwhite population changed significantly.  The IUD seems to have been a particularly important means of nonwhite contraception.  Some problems were found in using intercensal population data for relatively small areas.


Time loss and indirect economic costs caused by disease among Indians and Alaska Natives. A comparison with the general U.S. population.


Coccidioidomycosis in Los Angeles County.


Attitudes of married college students on overpopulation and family planning. A 1968 study of family size aspirations and attitudes toward contraception and the effects of overpopulation was conducted by interviewing 20 randomly selected third-year medical students and their wives from the University of California and  20 San Francisco State College students and their wives.  Couples in the 2 groups were compared to each other, as were persons desiring small families (2 or fewer children) to those wanting large families (4 or more children).  Although more medical students expected large families than State college couples (50% compared to less than 20%), a majority of both groups expected more children than they considered ideal for the average American family (a mean of 2.5  children).  Overpopulation was considered almost unanimously to be a problem, but much of the blame for crowding in the U.S.  was placed on members of lower socioeconomic classes.  All couples practiced contraception.  Those expecting large families (75% medical students) expressed less concern about future overpopulation problems and financial disadvantages of large families.  A change in basic attitude towards responsibility of population growth seems necessary on the part of many affluent Americans, represented by these students.


Vision testing by parents of 3 and one-half-year-old children.


Effect of heavy medical expenditures on low income families.


Incidence of obesity and overweight among Honolulu police and firemen.


Effects of health education methods on appointment breaking.


Internal Revenue Service policy on medical practice groups.


DDT and DDE in blood and DDA in urine of men exposed to 3 percent DDT aerosol.


Sarcocystis: development in cultured avian and mammalian cells. Sarcocystis, a protozoan that parasitizes muscle tissue of reptiles, birds, and mammals, including man, developed in avian and mammalian cell cultlures. Mctile banana-shaped organisms, released from cysts in grackle muscle, entered cells and transformed into enlarged ellipsoid or oblong stages, which developed into either multinucleate or cyst-like stages, or both.


Electron therapy with 6 MeV linear accelerator.


Computation of distribution of absorbed dose and absorbed dose rate from a scanning electron beam.


Changes in rhesus monkey fetal and maternal acid-base measurements following amniotic fluid bicarbonate of tris infusions.


Nutrition in surgical patients.

Nutrition in surgical patients.


Introduction to a formal theory of the dosage regimen calculation in intermittent chemotherapy of tuberculosis.


Classical eyelid border sign of neurofibromatosis.


Effect of organic nitrates on myocardial oxygen consumption in vitro. 1. Mannitol hexanitrate (MANHN), iditol hexanitrate and sorbitan tetranitrate, all at 442 muM, stimulate oxygen uptake by isolated rabbit atrial tissue.2. At the same concentration, glyceryl trinitrate decreased oxygen uptake, while isosorbide dinitrate and erythrityl tetranitrate had no effect.3. No simple correlation was found between the lipoid solubility or per cent nitration of these compounds and their effects on oxygen uptake.4. The stimulating effect of MANHN and its possible role as an uncoupler of oxidative phosphorylation is discussed.


Immunodiffusion reaction in equine infectious anemia.


Kinetic analyses of calcium movements in cell cultures. IV. Effects of phosphate and parathyroid hormone in kidney cells.


Introduction to viral diseases of dairy cattle.


Studies on the liver, lung, brain and blood of experimental animals infected with Toxocara canis.


The treatment of chronic subglottic stenosis by long-term intubation.


Echovirus as a cause of meningism.

Echovirus as a cause of meningism.


Those gaps.

Those gaps.


The role of rehabilitation in leprosy control.


Leucine-sensitive hypoglycaemia.

Leucine-sensitive hypoglycaemia.


The effect of tolylene diisocyanate on certain laboratory animals.


The heterogeneity and interrelationship of the precipitating antigens of the brucei subgroup trypanosomes.


The serology of amoebiasis.

The serology of amoebiasis.


Plasmodium falciparum infection induced in the black spider monkey, Ateles Fusciceps, and black howler monkey, Alouatta villosa.


Sarcocystis sp. in the slow loris, Nycticebus coucang.


Fine structure of Frenkelia microti and F. glareoli compared with that of Toxoplasma and Sarcocystis.


Urogenital lesions in 2 baboons (Papio anubis) infected with Schistosoma haematobium.


Fine structure in Thelohania parasites of Simulium larvae.


The preparation of free malaria parasites by nitrogen cavitation.


The viscosity of equine blood plasma: a new non-specific test.


Elimination of contamination from ophthalmic solutions for intraocular surgery.


Immunity to malaria: studies with Plasmodium knowlesi.


Health aspects of family planning. Report of a WHO Scientific Group.


The use of disodium edeta in endodontics.


Use of ion-exchange resin in preparing erythrocytes for magnesium determinations.


In vitro formation of ammonia in blood of g and man.


The sensitivity to complement of strains of Escherichia coli related to their K antigens.


The equilibrium constants of anti-D immunoglobulin preparations made from pools of donor plasma.


Distribution of organ antigens over the surface of thyroid cells as examined by the immunofluorescence test.


The orbital branches of the pterygopalatine ganglion and their relationship with internal carotid nerve branches in primates.


Properties of penicillinase from Bacillus cereus 569.


Purification and properties of follicle-stimulating hormone from sheep pituitary glands.


Identification of an apoceruloplasmin-like substance in the plasma of copper-deficient rats.


Some characteristics of human, bovine, and horse carbonic anhydrases as revealed by inactivation studies.


The anticonvulsant effects of phenobarbital, diphenylhydantoin and two benzodiazepines in the baboon, Papio papio.


Antagonism of the antiavoidance effects of various agents by anticholinergic drugs.


Influence of atherosclerosis on the composition, synthesis, and esterification of lipids in aortas of squirrel monkeys (Saimiri sciureus).


Lack of nucleotide sequence relationship among the temperate bacteriophage SPO2, Bacillus subtilis, and virulent bacteriophages beta 3 and beta 22. Radiolabeled phage SPO2 fragments were tested for the abiity to form interspecies deoxyribonucleic acid (DNA) duplexes with DNA from Bacillus subtilis and from phages beta3 and beta22. No reassociation, above control values, occurred between the DNA of phage SPO2 and that of its host or either of the virulent B. subtilis phages. It appears that extensive nucleotide sequence similarities between portions of host and phage DNA species are not necessary for the formation of the lysogenic state. The thermal elution profile of reassociated SPO2 DNA exhibited a normal distribution, indicating no heterogeneity in base composition. This differs from temperate enterophages whose DNA molecules contain regions of differing base composition.


Morphology and development of bovine ephemeral fever virus. The development of the virus of bovine ephemeral fever in mouse brain has been studied by electron microscopy. The virus particles are bullet-shaped, 70 by 145 nm, and slightly tapered toward the rounded end. The outer envelope is closely apposed to an electron-dense shell, about 12 nm thick, but no other internal structure is visible. The virus strains studied bud from the marginal membranes of neurones, but intracytoplasmic development, possibly aberrant, was also observed with one strain. Ephemeral fever virus is thus obviously a rhabdovirus, with points of resemblance to vesicular stomatitis, Flanders-Hart Park, and Kern Canyon viruses on the one hand, and to rabies virus on the other, but is structurally distinct from any of these.


Evaluation of stroma free hemoglobin solution: effects on renal function in cynomolgus monkeys. Rep No 838.


Urinary and faecal iron excretion in thalassaemia syndromes.


Megakaryocytes and platelets in central venous and arterial blood.


Quantitative study of the hemopoietic recovery after a sublethal X-irradiation in the mouse.


The nature of Rh blocking antibodies.

The nature of Rh blocking antibodies.


Presence of two Ph1 chromosomes in cells with 49 clone from patient in blast crisis of granulocytic leukaemia.


Gamma globulin levels in newborn with spina bifida cystica.


Plasma hemopexin and haptoglobin in hemolytic diseases of the newborn.


Bilirubin excretion in newborn infants. II. Conjugated bilirubin as a possible trigger for bilirubin excretion.


A medical care program for patients with cystic fibrosis in Maine--the first ten years.


Antenatal transplacental hemorrhage. Case report.


Production of complementfixation test antigen for serodiagnosis of theileriasis in white-tailed deer (Odocoileus virginianus).


Immunologic characterization of thyroactive iodinated casein.


Automatic analysis of amino-acid sequences in proteins and  peptides.


Treatment of baboon renal allotransplants with subcellular kidney cell fractions.


Radiobiological measurements with californium w52.


Multiple sclerosis: disturbed kappa: lambda chain ratio of immunoglobulin G in cerebrospinal fluid.


Practical applications of psychodrama: an action therapy for chronic patients.


DMOGRAP OF TUMORS OF HE CENTRAL NERVOUS YSTEM AMONG THE  Btu (African) population of the Transvaal, South Afric.


Iron concentratio n bal ganglia and cerebral cortex obtained by overloading rabbits and monkeys with iron dextran.


Fractured surfaces of myocardial cells.

Fractured surfaces of myocardial cells.


Ultrastructure of macroglobulinemia cells.


A study of the effects of possible toxic metabolites of uraemia on red cell metabolism.


Hereditary methemoglobinemia due to diaphorase deficiency. Report of a case of heterozygote presenting with cyanosis after birth.


Swiss type hereditary persistence of foetal haemoglobin in a case of acquired haemolytic anaemia.


Disseminated extrapulmonary nocardiosis presenting as a renal abscess.


Synthesis and relationship of L-glutaminyl-L-histidyl-L-prolinamide to the thyrotropin releasing hormone.


Characterisation of the hydroxy acids of Pseudomonas aeruginosa 8602.


Doxycycline treatment of gonorrhoea in cases with decreased penicillin susceptibility of gonococci.


Effects of high intensity impulse noise and rapid changes in pressure upon stapedectomized monkeys.


Evaluation of intrinsic and extrinsic penicilloyl-specific immunogenicity of penicillins. The use of penicillin hydrolysis catalyzed by 3,6-bis-(dimethylaminomethyl) catechol.


Rhesus erythrocyte agglutination in infectious mononucleosis.


The zeta potential and hemagglutination with Rh antibodies. A physiochemical explanation.


Characterization of a major allergen (cod.) chemical composition and immunological properties.


Reversible conformational changes in a leucine-binding protein from Escherichia coli.


Anatomical connections of viral system with limbic cortex of monkey.


Nigrofugal connections in the primate brain.


Subcortical projection of the magnocellular medial geniculate body of monkey.


Morphology and cytoarchitecture of the red nucleus of the domestic pig (Sus scrofa).


Rapid detection of Australia antigen by counterimmunoelectrophoresis.


The in vitro transfer of delayed hypersensitivity to rhesus monkey and human lympocytes with transfer factor obtained from rhesus monkey peripheral white blood cells.


Inhibition of natural cytotoxic rabbit antibody by human IgM: production of nontoxic rabbit serum for use as complement source.


Structural and antigenic relationships between avian immunoglobulins. II. Properties of papain- and pepsin-digested chicken, pheasant and quail IgG-immunoglobulins.


Measurement of rubella antibody by hemagglutination inhibition. II. Characteristics of an improved HAI test employing a new method for the removal of non-immunoglobulin HA inhibitors from serum.


Comparative study of antibodies to native and denatured DNA.


Some effects of parasitism by Babesia caballi on the tropical horse tick, Dermacentro (=Anocentor) nitens.


Reaginic activity associated with immunoglobulins other than IgE.


Programmes of analysis of mortality trends and levels. Report of a Joint United Nations WHO Meeting.


Histopathological lesions of Rhesus monkeys and chimpanzees infected with Schistosoma japonicum.


Fluorescent antibody techniques with mycobacteria. 3. Investigation of five serologically homogenous groups of mycobacteria.


Reticulocyte generation time and rate of discharge from the marrow.


Pre-leukaemic acute myelogenous leukaemia.


Characteristics of the RNA synthesized in vitro by human erythroblasts.


Eosinophil leucocytes and recovery from severe hypoxia.


Haemoglobin O Indonesia (alpha 116 Glu leads to Lys) in an Italian family.


A Ghanaian adult, homozygous for hereditary persistence of foetal haemoglobin and heterozygous for elliptocytosis.


Congenital deficiency of fibrinogen in two sisters. A clinical and haematological study.


Disturbances of hemostasis in acute myeloblastic leukemia.


Fine structural features of lymphocyte transformation induced by mercuric salts.


Sickle cell disease in Saudi Arabs.

Sickle cell disease in Saudi Arabs.


Identity of erythroblast precursors in bone marrow.


Effects of -calledsub-clinical spontaneous generalized and focal temporal epileptic EEG discharges on slow vertex-negative expectancy waves (CNV).


The effect of modern anaesthetic drug on the clinical EEG.


Oxygen dissociation curves of Macaca speciosa. Affinities of adult and fetal blood in vivo and in vitro.


The effects of rhesus-monkey erythrocyte stromata and hemolysate in experimental murine schistosomiasis mansoni.


The changing ecology of murine (endemic) typhus in Southern California.


Phosphorylation of bound adenosine monophosphate in the electron transfer particle.


The degradation of ribosomal RNA in E. coli by mitomycin C and AF-5, preferential inhibitors of DNA synthesis.


Isolation and characterization of nucleoprotein, "nuclear fraction," from Bacillus subtilis.


Studies on the structure of bovine kininogen: cleavages of disulfide bonds and of methionyl bonds in kininogen-II.


The effects of an acute load of thyroxine on the transport and peripheral metabolism of triiodothyronine in man. In order to examine the question of whether thyroxine-binding globulin (TBG) influences significantly the peripheral metabolism of 3,3',5-triiodo-L-thyronine (T(3)) in vivo, paired studies of the effects of a large intravenous load of L-thyroxine (T(4)) on the kinetics of (131)I-labeled T(3) metabolism were carried out in five normal subjects. After the T(4) load, both the early distributive loss of labeled T(3) from serum and the volume of T(3) distribution, observed after distribution equilibrium had been attained, were greatly increased. These alterations were consistent with those to be expected from displacement of T(3) from its extracellular binding sites. After the T(4) load, however, the fractional rate of T(3) turnover was decreased. This finding is ascribed either to competition between T(3) and T(4) for common intracellular pathways of degradation or excretion or to displacement of T(3) from sites of more rapid to sites of less rapid metabolism. These effects of alterations in the binding activity of TBG on the peripheral metabolism of T(3), together with those previously reported by others, are consistent with the interpretation that T(3) is significantly bound by TBG in vivo. However, it is suggested that the effects of alterations in the T(3)-TBG binding interaction on the metabolism of T(3) are obscured by alterations in the extracellular-cellular partitioning of T(4) that would result from concurrent alterations in T(4)-binding by TBG.


The measurement of the exchangeable pools of cholesterol in the baboon. Five male baboons were fed cholesterol-1alpha-(3)H until an isotopic steady state was approached in which the ratio of serum to dietary cholesterol specific activity was constant. The animals were then given single intravenous injections of cholesterol-4-(14)C, and the disappearance curves of the (14)C from the circulation were followed for 70-85 days. The total exchangeable cholesterol pools under these conditions were determined by carcass analysis at the end of the experiment and were shown to agree closely with the sums of the two exchangeable cholesterol pools as predicted from analysis of the die-away curve in terms of a two exchangeable pool model, assuming that entry into and exit from the system occur predominantly through the more rapidly exchanging of the two pools. These results have been interpreted as support for the validity of a model consisting of two exchangeable pools and one nonexchangeable or very slowly exchangeable pool as an approximation of over-all cholesterol metabolism in this species. In addition, an anatomical and chemical dissection of these pools was performed. While the three pool model is not applicable to every tissue, it has been possible to show that its general applicability in the intact animal stems from the fact that the major portions of the three cholesterol pools of the body lie within a limited number of tissues.


Studies of pancreatic alpha cell function in normal and diabetic subjects. The development of a glucagon radioimmunoassay with a relatively high degree of specificity for pancreatic glucagon made possible studies of alpha cell function in healthy nondiabetic subjects and in patients with diabetes mellitus. In the former group mean fasting plasma glucagon averaged 108 mumug/ml (SEM +/-10). In 12 juvenile-type diabetics fasting glucagon averaged 110 (+/-9) and in 33 adult-type diabetics the average was 114 (+/-8). The diabetic averages did not differ significantly from the nondiabetic subjects; however, when hyperglycemia was induced by glucose infusion in the nondiabetic subjects so as to simulate the fasting hyperglycemia of the diabetics, mean glucagon fell to 57 mumug (+/-8), which was significantly below the diabetic mean. In 28 healthy subjects the infusion of arginine elicited a rise in glucagon of at least 100 mumug/ml with a peak level averaging 331 mumug/ml (+/-22) at 40 min. This response to arginine was diminished but not abolished during hyperglycemia induced by simultaneous glucose infusion. In everyone of 45 diabetic subjects tested the infusion of arginine elicited a rise in glucagon of at least 140 mumug/ml to levels significantly greater than in nondiabetics. The peak glucagon level in juvenile-type diabetics averaged 458 mumug/ml (SEM +/-36) and in adult-type diabetics averaged 452 mumug/ml (SEM +/-38). The glucagon response to arginine was unrelated to duration of diabetes, to body weight, type of diabetic treatment, or to other known factors. Marked hyperresponsiveness of glucagon to arginine infusion was observed in two patients with advanced Kimmelsteil-Wilson disease. Glucagon levels were markedly elevated in certain patients with severe diabetic ketoacidosis before treatment with insulin. The findings suggest that alpha cell function is inappropriately increased in diabetes mellitus and could play a significant role in the diabetic syndrome.


The nature of colicin K from Proteus mirabilis. The colicinogenic factor K has been transferred from E. coli K 235 to Proteus mirabilis. The DNA of the colicinogenic Proteus has been shown to contain a small amount of a satellite DNA which presumably harbors the Col K factor. In the presence of mitomycin C the colicinogenic Proteus secretes colicin K into the growth medium. The bacteriocin has been purified by chromatography and obtained as an immunologically homogeneous substance unconjugated with other antigens of the Proteus bacillus. Proteus colicin K is a protein of relatively low molecular weight. It contains all of the usual amino acids except cysteine and is free of lipids and polysaccharides. The bacteriocin can be separated by electrofocusing into two major components. The latter have the same biological properties but differ in their specific electrical charges.


The proliferative and anamnestic antibody response of rabbit lymphoid cells in vitro. II. Requirement for adherent and nonadherent cells of the responses to particulate antigens in spleen cell cultures. Both primary and secondary responses to sheep erythrocytes and to Brucella abortus antigen have been obtained in cultures of dispersed rabbit spleen cells. Removal of adherent cells by repeated incubation of spleen cells on absorbent cotton diminished the ability of the spleen cell suspensions to give secondary as well as primary responses in vitro. When comparing cultures made in dishes and in tubes, the loss of responsiveness after incubation on cotton was much more evident in the dish cultures. It was concluded that the cell-to-cell interaction needed for immune responses to particulate antigens in vitro was more readily interfered with when the cells were spread over a larger surface area. The proliferative response to antigen, as measured by uptake of (3)H-thymidine in tube cultures of the sensitive spleen cells, appeared particularly resistant to the depletion effect of adherent cell removal. Dispersed spleen cells from sensitized mice gave a secondary response to sheep erythrocytes. This response was readily abolished by one incubation on absorbent cotton when the cells were cultured in dishes.


Soluble antigens obtained from influenza virus by treatment with non-ionic detergent. Highly purified influenza virus was degraded using anionic and non-ionic detergents. Best results were obtained using the non-ionic detergent Triton N 101. Tests showed that virus extracts contained neuraminidase and a substance that reacted specifically with rabbit antibody to virus haemagglutinin (specific serum blocking substance). Haemagglutination-inhibiting antibody was produced when virus extracts were inoculated into guinea-pigs. Immunodiffusion tests showed that extracts were complex. Host-specific material was regularly found. Under appropriate conditions S-antigen was detected as a single line pattern component. Two or more virus-specific materials were also present. One of these was probably neuraminidase and the other the specific serum blocking substance.


Male antifertility compounds: efficacy of U-5897 in primates (Macacamulatta).


The mechanism of perception.

The mechanism of perception.


The epidemiology of severe haemolytic disease of the newborn.


Gastrointestinal neurofibromatosis. A rare cause of chronic anemia.


A pharmacological analysis of aspirin.

A pharmacological analysis of aspirin.


Aflatoxin-induced hepatic injury in the African monkey.


Aflatoxin-induced fatal hepatitis? A case report from Uganda.


Haemodialysis cost reduction by artificial kidney storage: a simple, effective technique for re-use of coil kidneys. A simple method of storing and re-using coil dialysers was used in over 700 dialysers without serious complications but mantaining the efficiency of the dialyser. The method can reduce the expense of coil and tubing by as much as 70%, while the total cost of home or hospital dialysis can be reduced by as much as 15 to 25% even when the coil is re-used only once. Coils were re-used as many as 14 times, making the potential reduction in cost much larger. This technique deserves further evaluation in both hospital and home dialysis programmes.


Over-all evaluation of chemotherapy for ovarian cancer.


Postoperative irradiation for ovarian carcinoma with the cobalt-60 moving strip technique.


A double-blind evaluation of capuride (Pacinox) as a presurgical aid to sleep.


Clothiapin in the treatment of chronic schizophrenia.


A clinical evaluation of clopenthixol.

A clinical evaluation of clopenthixol.


Antipsychotic properties of loxapine succinate.


Treatment of children of lithium-responding parents.


The effects of newer sulfonamides on the protein binding of bilirubin.


Hyperbaric treatment of experimental tetanus in Swiss mice.


Variations in response to severe alloxan diabetes in arteriosclerotic and nonarteriosclerotic rats.


Histopathologic responses to severe alloxan diabetes in arteriosclerotic and nonarteriosclerotic rats.


Tumors in the urinary bladder of a monkey: induction with 2-nitronaphthalene.


Histochemical studies on urate oxidase in several mammals with special reference to uricolytic ability of primates.


Ossification in the region of the posterior longitudinal ligament as a cause of cervical myelopathy.


Quantification of antibody adsorption by cells and tissue residues.


Bronchial blood flow in pulmonary tuberculosis.


Origin and kinetics of monocytes and macrophages.


Autoantibodies to vitreous body in sheep.


The monocyte in cellular immunity.

The monocyte in cellular immunity.


An improved method for electrophoretic characterization of globin chains from hemolyzates, purified hemoglobins, and fractions selected from chromatographic separations of chains.


Thymic myoid cells and myasthenia gravis.


The self-assembly of RNA free protein subunits from bacteriophage MS-2.


The combining sites of yeast fructose diphosphate aldolase.


Dynamic interactions between cell wall polymers, extracellular proteases and autolytic enzymes.


Synthesis of a factor stimulating transcription in outgrowing Bacillus cereus spores.


Survival rates of nasopharyngeal cancer in California. A review of 516 cases from 1942 through 1965.


A specific colorimetric 5'-nucleotidase assay utilizing the Berthelot reaction.


Renal autotransplantation without ureteral division: an experimental study and case report.


Transfer RNA and cell differentiation.

Transfer RNA and cell differentiation.


Effect of nonsteroidal compounds on fertility.


Mechanism of perforation of the heart with production of hydropericdium by a venous catheter and its prevention.


Gonorrhea.

Gonorrhea.


Terpene compounds as drugs. 8. Bacteriological and pharmacological properties of terpenyl penicillins.


Treatment of severe pseudomonas infections of the bronchi. Experience in treating 81 patients with severe bronchial infection with Pseudomonas aeruginosa is described. For those who were desperately ill high doses of intravenous carbenicillin (18g. or more daily) were successful, even when initial carbenicillin resistance was present. For those who were less desperately ill lower doses of carbenicillin together with high doses of gentamicin (given both intramuscularly and by aerosol) comprised the treatment of choice. Gentamicin alone or colistin gave little or no benefit and cannot be recommended.


The control of DNA synthesis in macronuclei and micronuclei of a hypotrich ciliate: a comparison of normal and regenerating cells.


Sensitivity reactions to iron-dextran. Failure to detect precipitin type of antibodies by agar gel diffusion test.


Endotoxin-induced kinin (bradykinin) formation: activation of Hageman factor and plasma kallikrein in human plasma.


cid-soluble materialof adenovirus.

cid-soluble materialof adenovirus. Two methods are described for adenovirus capsid disruption and extraction of acid-soluble proteins from the viral core. The acid-soluble material of adenovirus consisted of three major proteins, one of them being selectively extracted after mild disruption of the virus particle. Some chemical properties of these proteins are reported.


Ultrastructure of secretory and high-polymer serum immunoglobulin A of human and rabbit origin. Electron micrographs of immunoglobulins A from human and rabbit colostrum, which were purified on tall agarose columns, revealed Y-shaped molecules (125 by 140 angstroms). The linear dimensions of the arms were 55 to 75 by 25 to 30 angstroms. A molecular model is postulated in which two immunoglobulin A monomers are superimposed on each other in a close-packed state with the secretory piece inserted in the constant region of the alpha-chains. High-polymer (11 or 13S) immunoglobulin A molecules (total span 100 to 110 angstroms) from human serum were composed of four arms (50 to 55 by 20 angstroms) joined at a contrast-rich center.


Physiological responses of infant rats to separation from their mothers. Decreases of 40 percent in cardiac and respiratory rates occur during the first 12 to 16 hours after 2-week-old rat pups are separated from their mothers. These rates decrease without significant alteration in activity level and despite maintenance of body temperature, of nutrition by intubation, of an intact litter, and of the home cage nest.


Genetic factors in congenital malformations. Report of a WHO Scientific Group.


Fixed eruption due to penicillin allergy.


The ultrastructure of the marine blue green alga, Trichodesmium erythraeum, with special reference to the cell wall, gas vacuoles, and cylindrical bodies.


Glucose 6-phosphatase deficiency: mechanisms of genetic control and biochemistry.


Acatalasemia in the mouse and other species.


Estimation of the molecular size of C-reactive protein and CX-reactive protein in serum.


Red cell enzymes of primates (Anthropoidea).


Thyrotropin secretion in rats after hypothalamic electrical stimulation or injection of synthetic TSH-releasing factor. Plasma thyroid-stimulating hormone (TSH) levels, as measured by radioimmunoassay, begin to rise within 5 minutes after initiation of electrical stimulation of the medial-basal hypothalamus, become significantly elevated at 10 minutes, and reach a peak at 10 to 25 minutes. Intravenous administration of synthetic thyrotropin-releasing factor induces a marked rise in plasma thyroidstimulating hormone which is maximal within 5 minutes after administration. These data are interpreted to indicate that there are neuronal structures within the medial-basal hypothalamus which release preformed thyrotropin-releasing factor. The claim (based on bioassay data) that pyroglutamyl-histidyl-proline amide is a potent thyrotropin-releasing factor has also been confirmed by using a highly specific immunoassay system.


Suppression and elimination of an island population of Culex pipiens quinquefasciatus with sterile males. The release of 8,400 to 18,000 males per day of Culex pipiens quinquefasciatus Say which had been exposed to a sterilizing agent (thiotepa), suppressed and eliminated an indigenous population of this mosquito on an island off the coast of Florida in a 10-week period. Sterile males were effective in seeking out and mating with females on the island.


Infection of Pseudomonas aeruginosa spheroplasts by RNA from a pilus phage.


Effects of photosensitization on plant virus protein.


Reptilian C-type virus: biophysical, biological, and immunological properties.


Morphogenesis of a virus in cats with experimental feline infectious peritonitis.


A lambda light chain cold agglutinin-cryomacroglobulin occurring in Waldenström's macroglobulinemia.


Human diploid cell cutures in diagnosis of echovirus 30 meningitis.


Reduced complement activity in sera of patients with Waldenström's macroglobulinemia.


Target cells of human ragweed-binding antibodies in monkey skin. I. Immunofluorescent localization of cellular binding.


The G4 subclass in IgG fractions prepared by ion-exchange chromatography.


Target cells of human ragweed-binding antibodies in monkey skin. II. Immunologlobulin nature of ragweed-binding antibodies with affinity for monkey skin mast cells.


Selectivity of proteinuria: an evaluation of the immunochemical and gel filtration techniques.


The endoscopic treatment of pharyngeal pouches and webs.


Effects of bilateral cervical vagotomy in primates.


Sublingual isosorbide dinitrate therapy versus sublingual acebo in angina pectoris.


Simulation of the thyroid hormone-binding protein interactions in human plasma.


Studies on obesity. II. Slow-moving thyroxine binding globulin in the sera of normal and obese subjects.


Professional health care costs.

Professional health care costs.


Comprehensive health planning and its relation to cost.


Government participation in health care costs.


Mechanism for financing health care costs.


Rising costs of medical care.

Rising costs of medical care.


Ibaraki virus, an agent of epizootic disease of cattle resembling bluetongue. 3. Experimental inoculation of cell cultures, embryonated eggs and laboratory animals.


Comparison of the protective effects of cholestyramine and ileal bypass in rhesus monkeys on an atherogenic regimen.


Determination of immunosuppressive activity in antilymphocyte sera.


Induction of immunologic tolerance to antilymphocyte globulin in man.


Immunologic consequences of human being and baboon cross circulation.


Eck's fistula encephalopathy: long term studies in primates and germfree dogs.


Effects of nutrition on intestinal adaptation following massive small bowel resection.


The effects of cervical sympathetic stimulation on cerebrovascular hemodynamics.


The site of action of carbon dioxide on cerebral circulation.


Distortion and displacement of the brain in experimental head injuries.


Spinal cord injury: sequential morphology and hypothermic stabilization.


Microvascular response to experimental spinal cord trauma.


Intracranial pressure measurements during whiplash.


Cerebrospinal fluid oxygen tension in hypoxia.


Fate of experimental incus autografts and homografts.


Immunologic sequelae of experimental thermal injury to the testis.


Periureteral reimplantation of the ureter into the bladder of dogs.


Effect of hyperglycemia on survival of bacteria.


Surface structure of normal human platelets.


Primary drug-resistant tuberculosis in active-duty military personnel: 1959-1968.


Primary drug-resistant tuberculosis in Vietnam veterans.


The reaction of Concanavalin-A with mycobacterial culture filtrates.


Comparison of three mediums for rifampin-susceptibility tests of mycobacteria.


Maintenance of virulence of Mycobacterium tuberculosis and Mycobacterium kansaii.


Somato-dendritic and dendro-dendritic synapses in the squirrel monkey lateral geniculate nucleus.


Delayed response deficit by cryogenic depression of frontal cortex.


A comparative study on hippocampal seizure discharges induced by direct and by indirect hippocampal stimulation in the cat and in the monkey.


Synthesis of a cyclic decapeptide corresponding to tyrocidine E.


Bacterial mutants of Hydrogenomonas lacking poly-beta-hydroxybutyric acid.


Concerning collagen and elastin in aortas of nine different species.


Assessing the health care needs of the aged.


Directional correlation studies of anomalous water in carbonic anhydrase.


Properties of 4-methylumbelliferyl-beta-galactosidase activities in human liver.


A methodological study of human leucocyte adhesiveness to glass beads.


Effect of prostaglandin E1 on forearm blood flow.


Renal inulin clearance versus total plasma clearance of 51Cr-EDTA.


Determination of diamine oxidase activity in normal human blood serum.


The electrophoretic pattern of alkaline phosphatase in schizophrenic females under long-term treatment with neuroleptic drugs and in young and old healthy women.


Presence of (alpha)-1-lipoprotein in patients with familial plasma lecithin: cholesterol acyltransferase deficiency.


Diamine oxidase isoenzymes in human blood plasma.


The effect of temperature, mabolic inhibitors, andEDTA on pgocytosis of polystyrene latex particles by human leucocytes.


Studies in metabolic nutrition employing chemically defined diets. II. Effects on gut microflora populations.


Nutrient demands imposed by surgery of the liver.


Comparison of the composition of arterial, venous, and capillary blood of the fetal monkey during labor.


Immunochemical comparison of human placental lactogen and placental proteins from other species.


The fine strucure of the placentalilli of the rhesus monkey (Macaca mulatta).


Dysoria, a new dimension of pathology.

Dysoria, a new dimension of pathology.


Corynebacterium diphtheriae carriership in Ugandan children.


Fractionation of ribonucleic acid and binding studies on columns of polylysine kieselguhr.


Dependence of experimental focal epilepsy on cyclic changes of vigilance.


Chemical disinfection in conjunction with ultrasonic energy.


Effects of stage of the menstrual cycle and gonadotrophins on luteinization of rhesus monkey granulosa cells in culture.


Stereoselectivity in the boron trifluride catalyzed rearrangement of a 1, 1-disubstituted ethylene oxide. Structural studies on penicillin derivatives. IV. A novel rearrangement of penicillin V sulfoxide.


Arthrography of the ankle.

Arthrography of the ankle.


Partial rupture of the tendo calcaneus with heterotopic ossification. Report of a case.


Purification of leucyl transfer ribonucleic acid synthetase from Escherichia coli.


Effect of Edta on Bacterial Resistance to antibiotics. A bacteriological and clinical study.


On some pharmacological and toxicological effects of a protozoan toxin "sarcocystin".


Defective lymphocyte transformation and delayed hypersensitivity in Wiskott-Aldrich syndrome.


In vitro determination of Bacillus thuringiensis, Bacillus cereus, and related bacilli.


Autogenous whole-joint replacement (the effect of the capsule).


Football injuries in the very young athlete.


Short-lived infection with enterococci of mouse oviduct following mating.


Studies of base-sequence homology among some cytoplasmic deoxyriboviruses of vertebrate and invertebrate animals. Relationships among some cytoplasmic deoxyriboviruses were investigated by deoxyribonucleic acid/ribonucleic acid hybridization experiments. Evidence of base-sequence homology between nucleic acids of different viruses was found within, but not between, the poxvirus and iridescent virus groups. Viruses of the vaccinia subgroup of poxviruses were 30 to 100% related, and the degree of relatedness was correlated with serological relatedness. Relationships within the iridescent virus group depended on the laboratory of origin and passage history of the virus strains used. None of these viruses was related to a superficially similar virus of frogs.


Viral and host deoxyribonucleic acid synthesis in Shope fibroma virus-infected cells as studied by means of high-resolution autoradiography. Incorporation of (3)H-thymidine by BSC-1 cells infected with Shope fibroma virus was studied by means of high-resolution electron microscopic radioautography. One-hour pulses with the radioactive precursor were given at various times after infection, during a one-step growth cycle of the virus. In the cytoplasm of infected cells, reacted grains occurred over foci of viroplasm; these foci are believed to represent the true sites of viral deoxyribonucleic acid (DNA) replication. Shope fibroma virus DNA synthesis began before 3 hr postinfection, reached a maximum at 8 to 9 hr, and then declined rapidly. It was demonstrated that the decline in (3)H-thymidine uptake is correlated with the onset of viral morphogenesis. In comparison with the noninfected culture, the nuclear labeling, which reflects host DNA metabolism, was slightly reduced by 4 hr postinfection. Inhibition became more marked as infection progressed, and host DNA synthesis was almost completely suppressed in late stages of viral development.


Morphological and cytochemical studies on lymphocytic choriomeningitis virus. Lymphocytic choriomeningitis (LCM) virus was observed by electron microscopy in thin sections of infected tissue cultures. The particles were pleomorphic and varied greatly in size. The smaller particles (50 to 200 nm) appeared to be spherical, whereas the largest (over 200 nm) were often cup-shaped. All particles contained one to eight or more electron-dense granules which were removed by ribonuclease. The particles were formed by budding from the plasma membrane and appeared to have spikes. The morphological evidence suggests that LCM should be considered as belonging to the presently unclassified group of lipoprotein-enveloped ribonucleic acid viruses.


Controlling costs of medical care by expanding insurance coverage. Study of a paradox.


An unusual form of fertilization in the malaria parasite of the Himalayan flying squirrel.


Pharmacological aspects of intracerebral spasm secondary to cerebral hemorrhage. Experimental observations.


The detection of Chagas' disease. A rapid haemagglutination test for special use in blood banks and epidemiological studies.


Insecticide resistance and vector control. Seventeenth Report of the WHO Expert Committee on Insecticides.


Baroreceptor responses and sympathetic activity during anaesthesia.


Clonal analysis of tumorigenesis of bovine adenovirus type 3 and isolation of a nontumorigenic variant.


Separation and characterization of products of two measles virus variants.


Derepression of tyrosinase synthesis in Neurospora by amino acid analogs.


Serological studies of two hybrid sea urchins.


Determination of spermatozoan motility.

Determination of spermatozoan motility.


Urinary estrone and plasma progesterone levels during the menstrual cycle of the rhesus monkey.


Origin of ovarian venous progesterone in the rhesus monkey.


Preparation and immunochemical investigation of Shigella polysaccharide labelled with 32P.


Muscle abscesses in children.

Muscle abscesses in children.


The identification of echoviruses by haemagglutination inhibition.


A study of gel diffusion test and immunoelectrophoresis on Brucella antigen--sonic extract.


Carbonic anhydrase from parsley leaves.

Carbonic anhydrase from parsley leaves.


The bacteriology of ear, nose and throat diseases.


Heading off health care costs through consumer education.


Metabolic products of adult Clonorchis sinensis: their composition and antigenic potential.


An electron microscopic study of mesosomes in Bacillus subtilis.


Monoamine oxidase activity in various tissues of monkey and rat.


The problem isn't how little we spend on the poor, but how badly we spend.


Secretory piece linked to IgM in individuals deficient in IgA.


In vitro reactivity of lymphocytes to particulate and soluble antigens.


Isolation of a protein responsible for aggregation of avian embryonic cells.


Factors affecting the density of intracellular infection of tissue culture cells by Trypanosoma cruzi.


Eukaryotes versus prokaryotes: an estimate of evolutionary distance. The divergence of nucleated organisms and bacteria was 2.6 times more remote in evolution than the divergences of the nucleated organisms into sparate kingdoms, as evidenced by genetic changes in cytochrome c and transfer RNA. The development of the genetic code through the differentiation of transfer RNA's for different amino acids was still more remote in evolution. The overall states of transfer RNA evolution in bacteria and nucleated organisms were comparable.


Brain mechanisms and vision; subcortical systems.


Ultrastructural study of microsporidian development. I. Nosema sp. Sprague, 1965 in Callinectes sapidus Rathbun.


Distribution of radioactive local anesthetics following intravenous regional anesthesia.


Cold reacting antibody in NZB-B1 mice.

Cold reacting antibody in NZB-B1 mice.


Hemostatic defects in dysproteinemias.

Hemostatic defects in dysproteinemias.


Ocular hazards of the Q-switched erbium laser.


Initial changes in burns: tissue changes in burned and unburned skin of rhesus monkeys.


The turnover rate of orosomucoid in burned patients.


The hemodynamic rationale of propranolol and nitroglycerin in the management of angina pectoris.


Esophageal diverticula in infants and children.


Surgical management of tuberculous enteritis.


Adrenergic innervation of blood vessels in the lung of some mammals.


The effect of immunosuppressive therapy of the murine lymphocytic choriomeningitis virus infection.


Immunochemical studies of oral Fusobacteria. 3. Purification of a group reactive precipitinogen.


Influence of inhibitors of DNA and protein synthesis on the kinetics of DNA uptake in Neisseria meningitidis transformation.


Serological properties of aqueous ether extracted endotoxin from Neisseria gonorrhoeae.


Serological cross-reactions of aqueous ether extracted endotoxin from Neisseria gonorrhoeae strains.


Effect of antilymphocyte serum on adoptive immunization of lymphocytic choriomeningitis virus carrier mice.


Structural basis for cardiac function.

Structural basis for cardiac function.


Pathogenesis of lesions of the autonomic nervous system of the mouse in experimental acute Chagas' disease. Light and electron microscope studies.


Alveolar macrophages: depression of protein synthesis during phagocytosis.


Specific irreversible enzyme inhibitors.


Pharmacology of viruses.

Pharmacology of viruses.


Toxicity of ozone, oxygen, and radiation.


Dissociation of beta-lactoglobulin near neutral pH.


Purification and properties of dihydroxy acid dehydratase from soluble and mitochondrial fractions of Neurospora crassa.


Species differences in drug metabolism.

Species differences in drug metabolism.


An immunochemical study of ovine pituitary follicle-stimulang hormone (FSH).


Release in vitro of 5-hydroxytryptamine from spindle cells of the domestic fowl.


Reovirus antibodies in animals in India.


In vitro susceptibility of gram-negative bacilli against gentamicin.


Metabolic fate of N-gamma-phenylpropyl-N-benzyloxy acetamide (W-1372) in rats, dogs, and monkeys.


Ethylene oxide penetration of the silicone coating used as a lubricant on disposable syringe rubber plunger tips and hypodermic needles.


Extrarenal and renal erythropoietin levels in human beings and experimental animals in the intact, anephric or renal allotransplanted state.


Keloid scars. Analysis of 89 patients.

Keloid scars. Analysis of 89 patients.


Gastrointestinal response fo malnutrition and starvation.


Thyroid C cells in experimental hyper- and hypomagnesaemia.


Hypoglycin--from ackee: a review.

Hypoglycin--from ackee: a review.


Allogenic heterotopic canine liver homotransplantation. 3. Technique of transplantation and general considerations.


Nomenclature of the brachial artery branches in the antebrachium of the domestic cat and dog.


Pharmacological, rheological and surgical attempts to improve myocardial blood flow during coronary occlusion in dogs.


Some further comparative histochemical studies of the vertebrate kidney.


Connection between structure and dry mass concentration of collagen fibre. I. Alteration in dry mass concentration of collagen fibres during aeging.


Some histochemical observations on the lipofuscin of vertebrate liver, kidney and cardiac muscle.


Flavin as a component of lipofuscin.

Flavin as a component of lipofuscin.


Assessment of subnormal urinary glucose as an indicator of bacteriuria in population studies. An investigation of 3,911 subjects between the ages of four and sixty-five years.


Simultaneous measurements of endolymphatic and perilymphatic fluid pressures before and during anaphylaxis and associated changes in cerebrospinal fluid, venous and arterial pressures.


Functional disorders of the pharynx and esophagus.


Immunochemical studies of oral fusobacteria. 5. Serological characterization of a group reactive antigen.


Nitrogen chlorosis in blue-green algae.

Nitrogen chlorosis in blue-green algae.


Combined induction of penicillinase in Bacillus cereus by means of various inducers. 3. Penicillinase induction in B. cereus by a single inducer after preincubation with another inducer.


The ultrastructure of the spiral ligament in the Rhesus monkey.


On the synthesis of heme.

On the synthesis of heme.


Primary resistance to the major drugs in tuberculous patients, in 1961-1966.


Urinary ketosteroids in the rhesus monkey.


Teratogenic compounds in Veratrum californicum (Durand) IX. Structure-activity relation.


Teratogenic compounds of Veratrum californicum (Durand) X. Cyclopia in rabbits produced by cyclopamine.


Study of the activity of erythrocyte carbonic anhydrase exposed to a high pressure gas environment.


Epistatic selection in the rhesus and MNS blood groups.


Epidemiological observations on bovine viral diarrhea-mucosal disease virus-induced congenital cerebellar hypoplasia and ocular defects in calves.


Blood groups and plasma substitutes (dextran and plasmagel).


Gargoylism in two families from north India.


Lethal factors in Pseudomonas aeruginosa.


Atherosclerosis research in non-human primates--with particular reference to Macaca mulatta.


A proposal for the management of Hodgkin's disease at The University of Alabama Medical Center Birmingham, Alabama.


Polyriboadenylate polymerase and its relationship with RNA polymerase.


R-factor mediated beta-lactamase in Pseudomonas aeruginosa.


In vitro cytotoxic test for detecting cell mediated immunity to soluble antigen.


Von Recklinghausen's disease associated with pheochromocytoma and carcinoid tumor.


Laryngeal swab method for the detection of tubercle bacilli in pulmonary tuberculosis.


The selective elimination of immunologically competent cells from bone marrow and lymphocyte cell mixtures. 3. In vitro test for detection of immunocompetent cells in fractionated mouse spleen cell suspensions and primate bone marrow suspensions.


Rapid collection of human leukocytes or lymphocytes from peripheral blood.


Modification of effects of proton and gamma radiation on the rectal mucous membrane by localypoxia.


Acute respiratory failure in the surgical patient.


On Oscillatoria redkei Van Goor.

On Oscillatoria redkei Van Goor.


Cyttoxic and cancerostatic activity of isothiocyanates and related compounds. V. ITC with sulphide and sulphone groups.


Trypanosomiasis cruzi in Aruba and Curaçao.


Epidemiological data for mental health planning. IV. Trends in "chronicity" in the New York State mental hospitals.


Autoimmunity in chronic brain syndrome. A preliminary report.


Transmission of African horse-sickness in mice.


Genetic recombination between plaque-purified mutants of influenza A-NWS and A-2-Singapore viruses.


Incidence of antibodies to adenovirus-associated viruses in patients with tumours or other diseases.


Observations on mice infected congenitally or neonatally with lymphocytic choriomeningitis (LCM) virus.


Subclassification of enteroviruses and ECHO virus type 34. Brief report.


Reactions of G-myeloma sera with rheumatoid arthritis sera.


Immunoglobulin A in the pig. I. Preliminary characterization of normal pig serum IgA.


Symposium on bacterial spores: X. Heat resistance of spore enzymes.


Symposium on bacterial spores: II. Genetics of sporulation in Bacillus subtilis Marburg.


Symposium on bacterial spores: XV. Spores in milk: problems associated with UHT processing.


Symposium on bacterial spores: I. Cytology of spore formation and germination.


Characterization of proteinases excreted by Bacillus subtilis Marburg strain during sporulation.


Physiological studies on early-blocked sporulation mutants of Bacillus subtilis.


Effect of the method of presentation of the medium on the germination and growth of single spores of Bacillus subtilis.


Symposium on bacterial spores: 3. Biochemical studies of spore core and coat protein synthesis.


Spontaneous closure of traumatic pancreatoduodenal fistulas with total intravenous nutrition.


Immunological determinants of pseudomonas infections of man accompanying severe burn injury.


Electroanesthesia currents: a comparison.


Obstruction of lacrimal sac caused by topical epinephrine.


Incontinentia pigmenti: Block-Sultzburger, Block-Seimens disease.


Allogeneic transplants using cobalt-60-irradiated teeth in monkeys.


Microcirculation of the perioral regions in the Macaca rhesus. II.


Biological nitrogen fixation in Lake Erie. Biological nitrogen fixation, as determined by acetylene reduction, occurs in Lake Erie. Fixation potential by blue-green algae in situ in water and by bacteria in collected sediments was demonstrated. Nitrogen-fixing activity occurred from June through November suggesting that it is significant over the extremes of seasonal variation in light, temperature, and nutrients.


Selective destruction of target cells by diphtheria toxin conjugated to antibody directed against antigens on the cells. Monkey-kidney cells bearing new surface antigens induced by infection with mumps virus were lysed selectively by diphtheria toxin conjugated to antibody against mumps antigens.


In vitro assay of suppressive properties of antilymphocyte sera on lymphocyte stimulation.


Serological and phage typing of Pseudomonas aeruginosa invading a municipal water supply.


Amino acid utilization by serologically grouped Pseudomonas aeruginosa strains.


Comparative studies on the taxonomic relationship between Mycobacterium abscessus and Mycobacterium borstelense. Incidence of Mycobacterium abscessus in monkeys.


Microbioassay of antimicrobial agents.

Microbioassay of antimicrobial agents. A previously described agar-diffusion technique for microbioassay of antimicrobial agents has been modified to increase sensitivity of the technique and to extend the range of antimicrobial agents to which it is applicable. This microtechnique requires only 0.02 ml of an unknown test sample for assay, and is capable of measuring minute concentrations of antibiotics in buffer, serum, and urine. In some cases, up to a 20-fold increase in sensitivity is gained relative to other published standardized methods and the error of this method is less than +/-5%. Buffer standard curves have been established for this technique, concurrently with serum standard curves, yielding information on antimicrobial serum-binding and demonstrating linearity of the data points compared to the estimated regression line for the microconcentration ranges covered by this technique. This microassay technique is particularly well suited for pediatric research and for other investigations where sample volumes are small and quantitative accuracy is desired. Dilution of clinical samples to attain concentrations falling with the range of this assay makes the technique readily adaptable and suitable for general clinical pharmacological studies. The microassay technique has been standardized in buffer solutions and in normal human serum pools for the following antimicrobials: ampicillin, methicillin, penicillin G, oxacillin, cloxacillin, dicloxacillin, cephaloglycin, cephalexin, cephaloridine, cephalothin, erythromycin, rifamycin amino methyl piperazine, kanamycin, neomycin, streptomycin, colistin, polymyxin B, doxycycline, minocycline, oxytetracycline, tetracycline, and chloramphenicol.


Evaluation of three cell culture systems as substrates for influenza virus assay. The propagation of various influenza virus strains in primary rhesus monkey kidney (RMK), primary hamster kidney (HK), and the MDCK-USD canine kidney (CK) cell cultures was compared. Virus-infected cultures were examined for cytopathic effect (CPE) and by performing the hemadsorption (HAd) technique. The highest HAd titers were found most often in HK, followed by RMK and CK. However, the CK cell line provided the best substrate for detecting CPE. Although influenza B strains tended to grow to higher titers, these strains produced less CPE than did the A strains.


Effect of pH of medium and size of inoculum on activity of antibiotics against group D Streptococcus (Enterococcus). Seventy-one clinical isolates of 5 species of group D Streptococcus (Enterococcus) were tested for susceptibility to 15 antibiotics at pH 5.0, 7.4, and 8.5. Penicillin G, ampicillin, cephalothin, cephaloridine, and novobiocin were considerably more active against all strains at pH 5.0 than in the more alkaline media. On the other hand, lincomycin, clindimycin, erythromycin, and gentamicin were moderately to markedly more active at pH 8.5. No important differences were noted in the susceptibility of the strains to kanamycin and streptomycin, at the pH levels tested, but the organisms were quite resistant to them in these tests. The various species differed quantitatively in their susceptibility to the individual drugs and in the effects of pH. The size of the inoculum also had a variable effect on susceptibility, depending on the species of Enterococcus, the antibiotics, and the pH of the test medium. The data suggest that, in the antibiotic treatment of urinary tract infections caused by Enterococcus, attempts should be made to achieve the optimum pH in the urine, particularly in view of the fact that organisms of this group are often resistant to several antibiotics in the usual tests.


Pulmonary absorption and retention of kanamycin after repeated inhalation administration of kanamycin aerosol. The absorption and retention of kanamycin by the pulmonary system was evaluated after aerosol administration to rats. Tissue level concentrations of the drug were assayed by the agar-plate bioassay method. Mean concentrations of 6.58 mug/g and 3.52 mug/g were found in the lung and kidney homogenates, respectively, 26 hr after the final exposure period. No detectable level was found in the plasma.


A new isolation and structure for the endotoxin from Microcystis aeruginosa NRC-1.


Production of high titers of enterotoxins for the routine testing of staphylococci. The cellophane-over-agar technique has been shown to give high titers of enterotoxins A, B, and C for routine testing of staphylococci for enterotoxigenicity.


Neurological development in infants of diabetic mothers.


Pulmonary hypersensitivity reactions.

Pulmonary hypersensitivity reactions.


Time-dependent Michaelis-Menten kinetics for an enzyme-substrate-inhibitor system.


Some aspects of the problem of regulating food intake and obesity.


Bacterial and fungal infections complicating parenteral alimentation in infants and children.


Intravenous dextrose-amino-acid feeding: the metabolic response in the surgical neonate.


Primary drug resistance in tuberculosis.


Basic problem of infected burn.

Basic problem of infected burn.


Parenteral nutrition: the age of the catheter.


Radio-immunoassay of gastrin using antiserum to porcine gastrin.


Optimal conditions for isolation of a neurotropic measles virus from brain tissue.


The induction of immediate and delayed sensitivity in the marmoset.


Immunologic test for chorionic gonadotropin in serum of the pregnant monkey (Macaca mulatta).


Hemagglutination properties of adenovirus types 20, 25, and 28.


Specificities of human antibodies to Australia antigen.