Interaction of cis-dichlorodiammineplatinum (II) with DNA.


The genetic relationship to two quantitative characters in Drosophila melanogaster. I. Responses to selection and whole chromosome analysis.


The genetic relationship of two quantitative characters in Drosophila melanogaster. II. Location of the effects.


The genetic structure of natural populations of Drosophila melanogaster. X. Developmental time and viability.


Nitroglycerin: the explosive drug.

Nitroglycerin: the explosive drug.


Interaction between carbenicillin and beta-lactamases from Gram-negative bacteria.


A study of specificity of cores fro group D streptococci.


Co-ordinate control of tryptophan, histidine and tyrosine enzyme synthesis in Bacillus subtilis.


Origin and composition of hepatic lymph proteins in the dog.


Specific detection of antigen-binding cells by localized growth of bacteria. A new method for the enumeration of lymphoid cells with specific surface-receptors for antigen is described, based on the use of beta-D-galactosidase (EC 3.2.1.23), either directly as an antigen or as a conjugated antigen. Binding of beta-D-galactosidase is revealed by its activity in releasing riboflavin from a synthetic substrate, riboflavin-beta-D-galactopyranoside. The riboflavin, inactive as a vitamin in the galactosidic form, becomes active when released by the enzyme, and can be detected by bioassay. Hence, lymphoid cells with receptors for beta-D-galactosidase on their surface can be detected after they have been exposed to the enzyme, washed, and then plated in agar containing riboflavin-beta-D-galactopyranoside, streptomycin, riboflavin-deficient medium, and a streptomycin-resistant strain of Streptococcus faecalis that requires riboflavin. Release of riboflavin is signalled by the growth of characteristic bacterial colonies over the cell that bound beta-D-galactosidase.


Production of albumin and other serum proteins by clonal cultures of normal human liver. Clonal cell strains have been isolated from normal human liver. These cells, while resembling fibroblasts morphologically, function as hepatocytes, as shown by their ability to synthesize and secrete an antigen identical to human serum albumin. Human diploid and aneuploid cell lines from nonliver sources do not exhibit this property. The spectrum of serum proteins synthesized varied from clone to clone and cell line to cell line.


RNA polymerases of maize: partial purification and properties of the chloroplast enzyme. A DNA-dependent RNA polymerase has been solubilized and partially purified from washed chloroplasts prepared from maize seedlings. The purified enzyme was completely dependent on added DNA after purification by phospho- or DEAE-cellulose chromatography. On glycerol density gradients, the enzyme ran ahead of a marker with a sedimentation constant of 18 S, indicating a molecular weight of 500,000 or more. The instability of the highly purified enzyme made intensive study difficult, but the properties of the enzyme purified by phosphocellulose chromatography are reported. Template specificity varied during purification but the activity was always higher with denatured than with native DNA and the preference for maize DNA over calf-thymus DNA increased during purification. The enzyme required magnesium for optimal activity, was inhibited by salt concentrations in excess of 0.1 M, and had a temperature optimum of 48 degrees C. The chloroplast enzyme differed from similar activities so far reported from maize or other sources, particularly in the high salt concentrations needed to elute it from phosphocellulose. The soluble, DNA-dependent enzyme was not inhibited by either alpha-amanitin or by rifamycin-SV under the assay conditions used.


Evidence for position-effect suppression of the ribosomal RNA cistrons in Drosophila melanogaster. Unambiguous evidence is presented that two X-chromosome inversions produce lethality in X/O males because of position-effect suppression of genes in the basal heterochromatin. The data support the hypothesis that the ribosomal RNA cistrons are the genes suppressed. There is evidence for a region in the X basal heterochromatin that may act as a regulator of rDNA activity.


Chloroplast RNA populations in dark-grown, light-grown, and greening Euglena gracilis. RNA preparations from dark-grown, light-grown, and greening Euglena gracilis have been compared by polyacrylamide gel electrophoresis and by hybridization to Euglena chloroplast DNA. Chloroplast ribosomal RNA is not detected in dark-grown cells; its abundance increases in greening cells over a 72 hr period until the concentration characteristic of light-grown cells is reached. Other RNA species complementary to chloroplast DNA are present in comparable abundance in light-grown, dark-grown, and greening cells.


Imaginal disc abnormalities in lethal mutants of Drosophila. Late lethal mutants of Drosophila melanogaster, dying after the larval stage of development, were isolated. The homozygous mutant larvae were examined for abnormal imaginal disc morphology, and the discs were injected into normal larval hosts to test their capacities to differentiate into adult structures. In about half of the mutants analyzed, disc abnormalities were found. Included among the abnormalities were missing discs, small discs incapable of differentiating, morphologically normal discs with limited capacities for differentiation, and discs with homeotic transformations. In some mutants all discs were affected, and in others only certain discs. The most extreme abnormal phenotype is a class of "discless" mutants. The viability of these mutant larvae indicates that the discs are essential only for the development of an adult and not of a larva. The late lethals are therefore a major source of mutants for studying the genetic control of disc formation.


Plaque formation of dengue viruses in LLC-MK 2  cell cultures.


Genetic red cell abnormalities in Trengganu and Perlis (West Malaysia).


Current laboratory patterns of typhoid fever.


Mechanism of haemolysis in monkeys infected with Plasmodium coatneyi.


Inflammatory cellular reaction in hypertensive vascular disease.


Variations in gastrointestinal functions influencing the absorption of drugs.


A role for folic acid conjugase in the regulation of methionine synthesis by Coprinus lagopus.


Australia antigen--Rhodesia. 1. Pilot survey.


Specific antibodies to human prostatic acid phosphatase.


HL-A antibodies and some immunological problems of pregnancy.


The "sensitivity" of resting and dividing cells.


Outbreak of malignant lymphoma in rhesus monkeys.


A comparison of the cardiovascular actions of daunomycin, adriamycin and N-acetyldaunomycin in hamsters and monkeys.


Spirolactone inhibition of aldosterone induced nuclear RNA synthesis in toad urinary bladder.


Inhibition of anti-streptokinase antibody formation.


Heat resistance of vegetative form and spore antigens of Bacillus megaterium "in situ" and in "solution".


Experience with serologic tests for amebiasis.


Studies of carcino-fetal proteins. 3. Development of a radioimmunoassay for  -fetoprotein. Demonstration of  -fetoprotein in serum of healthy human adults.


Effect of withaferin A on ehrlich ascites tumor cells. II. Target tumor cell destruction in vivo by immune activation.


The effect of a progestational agent on ureteral physiology.


Species variation in the renal distribution of antibacterials.


Antigenic profiles of proteinpolysaccharide complex from human costal cartilage. I. Antigenicity of sialoprotein moiety.


Sex ratio compensation in Drosophila melanogaster.


The I blood group system of rhesus monkeys.


The J, K, L, M, N, and O blood group systems of Rhesus monkeys.


Genetic effects of low frequency stress on Drosophila melanogaster.


Paired ionization chambers for measurement of neutrons and gamma rays.


A new technique for manipulation and study of Drosophila melanogaster.


Lysine decarboxylase activity in broth and agar media. Four lysine decarboxylase media were studied by testing them with 305 Enterobacteriaceae and 42 nonfermenting bacilli. A comparison was made between lysine decarboxylase broth medium (Moeller base) and Johnson's semisolid agar without lactose and Bachrach's broth medium and lysine-agar slants which contain lactose. The nonlactose media, lysine decarboxylase broth and the semisolid medium of Johnson, were the best media for use with all of the bacteria studied. The exclusion of lactose from lysine decarboxylase medium seems desirable to extend the usefulness of this medium among members of the Enterobacteriaceae. When the results with lysine decarboxylase broth and Johnson's semisolid medium without lactose were compared, a 6% difference existed between the results obtained with lysine decarboxylase broth and Johnson's semisolid agar. When the results with Bachrach's broth and lysine-agar slants with lactose were compared, a 1% difference existed between Bachrach's broth and the agar slant method. At times, reading and interpretation were difficult because of intermediate degrees of color change. The inability of Pseudomonas aeruginosa or Herellea to utilize glucose under the anaerobic condition of the medium makes the lysine decarboxylase test an undesirable procedure for these organisms. Of the four test media used, the lysine-lactose-agar slants seemed to be the least desirable because of the more frequent occurrence of indistinct color reactions and shifts in color.


Intracellular proteases of Bacillus stearothermophilus. Cell-free extracts of Bacillus stearothermophilus have been shown to exhibit proteolytic activity toward casein as well as specific activity to catalyze the hydrolysis of furylacryloylglycyl-l-leucine amide, furylacryloylglycine, and carbobenzoxyl-glycine-p-nitrophenyl ester, indicating the presence of a neutral proteinase, a carboxypeptidase-like enzyme, and an alkaline proteinase. The neutral proteinase and carboxypeptidase-like activities were separated by gel filtration over Bio-Gel P-60, and both were reversibly inhibited by 1, 10-phenanthroline. The esterase activity was inhibited by diisopropylfluorophosphate, which did not affect other enzymatic activities and was insensitive to 1, 10-phenanthroline and ethylenediaminetetra-acetic acid.


Comparison of three methods used to isolate dengue virus type 2. During the 1969 dengue epidemic in Puerto Rico, human sera and Aedes aegypti mosquitoes were collected for virus isolation and identification. Three methods of isolation were used and compared. In the first method, we inoculated newborn mice by the intracranial route, noted any signs of illness, and serially passed specimens in mice until virus was isolated. In the second method, we inoculated tube cultures of LLC-MK(2) cells, noted any cytopathic effect (CPE), and assayed fluids for virus by plaque formation in LLC-MK(2) cell monolayers. The third method was different from the second only in that the original specimens were first inoculated into fluid cultures of Singh's A. albopictus cells. No significant CPE was seen in LLC-MK(2) cultures; however, distinct syncytial CPE was observed in A. albopictus cells. About the same number of virus isolates were made in each isolation system. Virus isolates from both sera and mosquitoes were identified as dengue type 2 by a plaque-reduction neutralization test in LLC-MK(2) cells. The utility of the three methods, individually or in combination, is discussed and related to diagnostic and epidemic situations.


Growth of respiratory syncytial virus in suspension cell culture. Respiratory syncytial virus, Burnett strain, adsorbed efficiently and grew to high titers in suspension cultures of HEp-2 and MA-160 cells. Our results compared favorably with previous experience with the growth of respiratory syncytial virus in monolayer cell cultures. The use of suspension cell cultures provides a convenient and simple procedure for producing high-titering respiratory syncytial virus pools.


Effect of relative humidity on formaldehyde decontamination. Death rate studies were conducted to determine the effect of varying the concentration, humidity, and type of surface on the sporicidal activity of formaldehyde gas. Washed and unwashed spores were similarly exposed to detect the influence of residual nutrient growth medium upon the rate of kill. The results indicated that the sporicidal activity of formaldehyde gas varies directly with its concentration. Relative humidities (RH) over 50% proved essential for sterility. Spores on a porous surface (cotton cloth) were more readily killed at lower RH than those on a nonporous surface (glass). The reverse occurred at very high RH. At 75% RH, the unwashed spores on glass were killed faster than the washed spores.


Substituted diazenes: effect on the growth of enterobacteria and possible use as selective agents for isolation of pseudomonads. Incorporation of various diazenes into Trypticase soy media appeared selectively to permit the growth of pseudomonads while inhibiting the growth of a variety of enterobacteria. One of these diazenes, diamide (diazenedicarboxylic acid bisdimethylamide), was shown to be bactericidal for pure cultures of Escherichia coli, Proteus sp., and Salmonella enteritidis and to cause a 1- to 2-hr delay in the growth of Pseudomonas aeruginosa. When mixtures of these four organisms were inoculated into Trypticase soy broth or Trypticase soy agar (TSA) containing diamide, P. aeruginosa grew in overnight cultures. TSA containing diamide was also used successfully to isolate pseudomonads from soil, clinical urine specimens, fish, ground beef, ground pork, and ground veal.


Counter-immunoelectrophoresis: rapid method for detecting group-specific antigen and antibodies associated with oncogenic ribonucleic acid viruses. Counter-immunoelectrophoresis was used for the quantitation of group-specific antigen and antibodies of C-type ribonucleic acid leukemia and sarcoma viruses.


Tobramycin (nebramycin factor 6): in vitro activity against Pseudomonas aeruginosa. Tobramycin (factor 6 of the nebramycin complex) is a new aminoglycoside antibiotic isolated from Streptomyces tenebrarius which is active against S. aureus, Enterobacteriaceae, and Pseudomonas aeruginosa. Susceptibility to tobramycin of 96 strains of P. aeruginosa, including 45 recent isolates from blood, was studied by using agar and broth dilution methods. The minimum inhibitory concentration (MIC) for 83 of 96 strains was 3.12 mug/ml or lower in Mueller Hinton agar; MIC values were two to eight times lower in Mueller Hinton broth tests. Agar dilution MIC values were generally lower than those obtained in parallel tests with gentamicin. Killing curves obtained from serial sampling of broth cultures showed a 100- to 10,000-fold decline in viability of log-phase organisms within 30 min of exposure to the drug. Two-dimensional agar dilution tests with carbenicillin and tobramycin with 79 strains showed additive or synergistic effects; no antagonism was documented. Seventy-eight of 79 strains were inhibited by a combination of 50 mug of carbenicillin per ml and 1.56 mug of tobramycin per ml, blood levels which seem attainable in man. Tobramycin appears to be a potent, rapidly bactericidal antibiotic against P. aeruginosa and merits clinical evaluation.


Prototype of a fully automated device for determination of bacterial antibiotic susceptibility in the clinical laboratory. A completely automated system for the performance of antibiotic susceptibility tests in the clinical laboratory is described. With a modicum of personnel involvement, data on 40 specimens tested against 13 antibiotics are obtained every hour after an initial 3-hr period. The step by step explanation of the functioning of this prototype system, based on a thoroughly tested manual model, is presented. The system compares well with the standard diffusion test and has a potential for application to other endeavors of the clinical microbiology laboratory with a comparable saving in time and labor.


Evaluation of methods used to purify acid-extracted group A streptococcal M protein. The literature includes descriptions of both acid-soluble and acid-insoluble M protein in the preparation of "hot acid-extracted group A streptococcal M protein." We present evidence for the contamination of crude type 1 acid-insoluble M protein. The purification of preparations of crude and partially purified acid-soluble type 1 and type 12 M protein is described. Our quantitative criteria for purification were recovery of M precipitin activity, improvement in specific activity, and removal of carbohydrate. Exclusion of nucleic acid is also discussed. Greater purification in a single passage was found with a carboxymethylcellulose column (with acidic elution) than with hydroxyapatite, diethylaminoethyl-Sephadex, or carboxymethyl-cellulose (with neutral elution) columns or with ammonium sulfate fractional precipitation. Carboxymethylcellulose with acidic elution was found to be a satisfactory standard laboratory procedure for the preparation of purified acid-extracted (acid-soluble) group A streptococcal M protein.


Production of L-arginine by arginine hydroxamate-resistant mutants of Bacillus subtilis. l-Arginine hydroxamate inhibited the growth of various bacteria, and the inhibition was readily reversed by arginine. l-Arginine hydroxamate (10(-3)m) completely inhibited the growth of Bacillus subtilis. This inhibitory effect was prevented by 2.5 x 10(-4)ml-arginine, which was the most effective of all the natural amino acids in reversing the inhibition. l-Arginine hydroxamate-resistant mutants of Bacillus subtilis were isolated and found to excrete l-arginine in relatively high yields. One of the mutants, strain AHr-5, produced 4.5 mg of l-arginine per ml in shaken culture in 3 days.


Presence of hemagglutinin in the vaccinia virion.


Zika virus infection of the central nervous system of mice.


Studies of laryngotracheitis virus in avian tissue cultures. IV. Effect of diethylaminoethyl-dextran on adsorption and elution.


Non-specific serum inhibitors are irrelevant in adenovirus haemagglutination. Brief report.


Studies on rubella virus hemagglutination. I. Activation by various treatments.


Sedimentation constant of hepatitis-associated antigen. Brief report.


The repeated transfer RNA genes of animal cells in culture.


The effect of trypsin on  30 -S and  50 -S ribosomal subunits of Escherichia coli.


Analogies in protein pattern and conformation among ribosomes from different classes of vertebrates.


Comparative and immunochemical studies of bovine adenosine deaminases.


Protein and enzyme variation in Drosophila.


Protein synthesis in a cell-free preparation from Tetrahymena pyriformis GL.


Horseradish peroxidase in plasma studied by gel filtration.


Evaluation of new active forms of chlormphenicol palmitate in the treatment of typhoid and paratyphoid fevers in children.


Asymptomatic bacteriuria in pregnancy in Assiut, Upper Egypt. I. Report on the first one thousand cases investigated.


Serology of rumen bacteroides.

Serology of rumen bacteroides.


The rapid detection and determination of sparse bacterial populations with radioactively labelled homologous antibodies.


Effect of dilution rate on the outcome of chemostat mixed culture experiments.


Reproductive systems of the North Indian langur (Presbytis entellus entellus Dufresne).


DNA density of oncogenic and non-oncogenic simian adenoviruses.


Degradation of brome mosaic and tobacco mosaic viruses in bentonite.


Some environmental influences on metafemale viability in Drosophila melanogaster.


Differential response of prunus necrotic ringspot and Tulare apple mosaic viruses to stabilizing agents.


Early and late gene function in bacteriophage SP82.


Structure and synthesis of a lipid-containing bacteriophage. IX. Serological disparity between bacteriophage PM2 and its host cell components.


Demonstration of genetic control of esterase-A in Drosophila melanogaster.


Differences in thymidine kinase-inducing ability of herpesvirus types 1 and 2.


On the fate of adenovirus DNA in KB cells.


Hydrogen ion effects on the thermal inactivation of cowpea mosaic virus.


A mathematical model of the equilibrium distribution of chemical complexes and the biological effects of chemical binding.


Pulmonary ossification in a cow.

Pulmonary ossification in a cow.


Role of endogenous glutathione in the metabolism of glyceryl trinitrate by isolated perfused rat liver.


Effects of fluorouracil on RNA synthesis in Bacillus cereus.


Quinine: effect of Tetrahymena pyriformis. 3. Energetics of isolated mitochondria in the presence of quinine and other antimalarial drugs.


Effect of a hostile environment on Pseudomonas aeruginosa.


Paratyphoid in a 13 year old girl.

Paratyphoid in a 13 year old girl.


Cardiac catheterization and angiocardiography.


Lesions of the central nervous system in multiple neurofibromatosis.


VCN--inhibited strains of Neisseria gonorrhoeae.


Precipitation in gel test in diagnosis of smallpox.


Sympathectomy in the management of frostbite: an experimental study.


Conversion of (4- 14 C)progesterone to androsterone by female rhesus monkeys (Macaca mulatta).


Ribosomal proteins. XXV. Immunological studies on Escherichia coli ribosomal proteins.


Clearance of iodinated human follicle-stimulating hormone in Macaca mulatta.


Determination of carbaryl as an amide derivative by electron-capture gas chromatography.


Motor control functions of the lateral hypothalamus and adjunctive behavior.


Metabolites of carbaryl (1-naphthyl methylcarbamate) in chicken urine.


Lactoferrin--specific localization in the nuclei of human polymorphonuclear neutrophilic leukocytes.


Isolation of foamy virus types 1 and 2 from primary rhesus monkey brain cultures.


In vitro isolation and characterization of the GA strain of feline sarcoma virus.


Degradation of 1-naphthol in sea water.

Degradation of 1-naphthol in sea water.


ST feline sarcoma virus. Biological characteristics and in vitro propagation.


Degradation of aldrin and heptachlor in field soils during a ten-year period. Translocation into crops.


Alpha chain disease.

Alpha chain disease.


Studies of an unusual biclonal gammopathy: implications with regard to genetic control of normal immunoglobulin synthesis.


Pathologic conditions associated with plasma cell dyscrasias: a study of 806 cases.


Immunochemistry of the Rh system. V. Determination of Rh agglutinating activity and IgG content of sequential eluates for the assay of Rh antibody.


Antagonism limit of penicillin G and chloramphenicol against Neisseria meningitidis.


The mode of hypotensive action of newly synthesized sydnonimine derivatives.


Synthesis of poly (d(A-s 4 T)-d(A-s 4 T)) by Bacillus subtilis DNA polymerase.


Trypanosoma cruzi: agglutination activity of enzyme-treated epimastigotes.


Babesia canis and Babesia gibsoni: soluble and corpuscular antigens isolated from blood of dogs.


Studies on vitelline cell of monogenea. II. Characterization of o-diphenol oxidase.


Ascaris suum: immunoglobulin responses in mice.


Methods for transfecting cells with nucleic acids of animal viruses: a review.


The effects of temperature and aging of Drosophila males on the frequencies of XXY and XO progeny.


DNA macromutant identified as Flavobacterium. Total lack of immunologic relationship to Flavobacterium.


Effect of prostaglandin E 1  on adjuvant arthritis.


Human IgG subclasses in maternal and fetal serum.


Health education in health aspects of family planning. Report of a WHO Study Group.


Fingerprints and the determination of zygosity in twins.


Two orinetational features of compact bone as predictors of split-line patterns.


The population structure of south-central Bougainville.


A review of cell culture contaminations.


The distal femoral anatomy of Australopithecus.


Metric variability of the postcanine dentition in colobus monkeys.


Frequency of Au-SH antigen and antibody in blood donors.


The musculature of the ureter in mammals. A comparative study.


Recent developments in light and electron microscope radioautography.


Isolation of Montana snowshoe hare serotype of California encephalitis virus group from a snowshoe hare and Aedes mosquitoes.


Ciliary-iris hormone regulates eye tension.


Blood parasitism of some fishes from Montana and Yellowstone National Park.


Osseous metaplasia in the adrenal cortex of a two-toed sloth.


These are the big problems--and there are no solutions.


Nuttallia meri sp.nov.--a new piroplasm from Psammomys obesus in the lower Jordan Valley.


The effects of supervoltage and intracavitary radiotherapy.


Increased concentration of radio-labeled histamine in the venous effluent of dog gracilis muscle during reflex dilatation.


Ascorbate oxidase formation in the cucumber seedling.


Gene therapy: a potentially invaluable aid to medicine and mankind.


The phenoloxidases of the ascomycete Podospora anserina. Microheterogeneity of laccase II.


Australia antigen: physical and chemical properties.


Further studies on the protein bound to the messenger RNA in mammalian polysomes.


Observations on the pharmacology of barbiturates in monkeys (Macaca mulatta) exposed to gamma-neutron radiations.


The distribution of ABO and Rh blood groups in North Indian populations.


Further data on the genetic linkage relations of the adenosine deaminase locus.


Unusual albumin variants in Indonesians and Malayan aborigines.


German health insurance: the evolution and current problems of the pioneer system.


Serum  -lipoprotein polymorphism in Greenlanders. Frequency of the Ag(x) factor.


Social security for medical care: is it justified in developing countries.


The British National Health Service: professional determinants of administrative structure.


Social security and health care patterns in Chile.


Federal-provincial insurance for hospital and physician's care in Canada.


Changes induced in the ultrastructure of the cytoplasmic and intracytoplasmic membranes of several Gram-positive bacteria by variations in OsO 4  fixation.


A micromethod for the anaerobic utilization of glucose by staphylococci.


Effect of immunosuppression on the development of the adjuvant-induced granuloma in mice.


Chlorpromazine effects on macromolecular syntheses in synchronized tetrahymena.


Behavioral effects of prolonged partial social isolation in the rhesus monkey.


Food-motivated behavior in three species of macaques.


The development of studies in health manpower. Report of a WHO scientific Group.


Expenses for hospital and institutional care during the last year of life for adults who died in 1964 or 1965.


Interaction of Escherichia coli ribosomes with natural and synthetic templates.


Familial partial thyroxine-binding globulin deficiency.


Shock effects on Euglena gracilis: the effect of the pressure duration.


Kynurenine localization in the egg of Drosophila melanogaster.


Enzymatic reactions in the presence of non-ionic polymers.


Role of autolysins in the killing of bacteria by some bactericidal antibiotics. The rapid lysis of Bacillus licheniformis NCTC 6346 and B. subtilis 168 trp caused by vancomycin and d-cycloserine can be inhibited by stopping protein synthesis. Protein synthesis must be stopped for more than one doubling time of the cells before addition of wall inhibitors. Poorly lytic mutants (lyt(-)) of B. licheniformis required 10 to 20 times the concentration of vancomycin or cycloserine to be added to growing cultures to cause even slow lysis. At lower concentrations growth of the mutants is stopped, but the bacteria remain fully viable. Sensitivity of mucopeptide synthesis to vancomycin is the same in both mutants and parent. Sensitivity to the action of d-cycloserine is slightly less in the mutant than in the parent.


Regulation of two aspartokinases in Bacillus subtilis. When grown on minimal glucose medium, transformable Bacillus subtilis strains contained two distinct aspartokinases (ATP:l-aspartate 4-phosphotransferase, EC 2.7.2.4). One of these enzymes was inhibited by l-lysine (Lys), whereas the other was insensitive to inhibition but was activated by l-leucine. None of the other amino acids tested had any effect, and the addition of l-threonine did not enhance the inhibition by Lys, in contrast to the concerted inhibition observed for other bacilli. At the end of exponential growth, the Lys-sensitive aspartokinase activity decreased, whereas the Lys-insensitive activity remained relatively constant throughout the stationary phase. The two activities were separated by (NH(4))(2)SO(4) fractionation and Sephadex G-200 chromatography. Growth in the presence of Lys reduced the specific activity of aspartokinase by about 50% and eliminated the inhibition by Lys. In extracts of these cells, only Lys-insensitive activity was found upon (NH(4))(2)SO(4) fractionation and Sephadex G-200 chromatography. Lys apparently repressed the synthesis of the Lys-sensitive enzyme.


Evidence suggestive of compartmentalization of deoxyribonucleic acid-synthesizing systems in freeze-treated Bacillus subtilis. Freezing of Bacillus subtilis in liquid nitrogen results, upon thawing of the cells, in an enhanced deoxyribonucleoside triphosphate and reduced thymidine (Tdr) incorporation into cellular deoxyribonucleic acid (DNA). The DNA synthesized from thymidine triphosphate (TTP) was made by a "repair"-type system as determined by density transfer experiments. The mono- and diphosphate precursors were also incorporated by a "repair"-type synthesis. When Tdr was used as the radioactive precursor in the assay mixture, the product was only that expected from a semiconservative synthesis. Superlethal ultraviolet light exposure of the freeze-treated cells stimulated incorporation of phosphorylated precursors into DNA. Tdr uptake was greatly reduced by ultraviolet exposure, and only repair synthesis was observed. TTP and Tdr do not compete with one another in this system. The possibility that two DNA synthesizing systems exist in separate, non-mixing cellular compartments is considered.


Detection of a rapidly metabolizing portion of the membrane cardiolipin in Haemophilus parainfluenzae. Heterogeneity in the metabolism of cardiolipin (CL) has been detected in Haemophilus parainfluenzae. Pulse-chase experiments showed that a portion of the total CL incorporated and then lost (32)P much more rapidly than the rest of the CL in the cells. The metabolism of each phosphate of the CL differed. The phosphate of the phosphatidyl glycerol (PG) portion of the CL had a more active metabolism than the phosphate of the phosphatidic acid portion of the molecule. Only a portion of the PG pool contributed to the formation of CL. Ethylenediaminetetraacetic acid inhibited the CL-specific phospholipase D in vitro and, when added to growing cells, resulted in more rapid PG metabolism, suggesting that CL hydrolysis contributed to the PG pool.


The management of Hodgkin's disease: evolution of radiotherapy concepts.


Regulation of the mandelate pathway in Pseudomonas aeruginosa. The pathway of mandelate metabolism in Pseudomonas aeruginosa is composed of the following steps: l(+)-mandelate --> benzoylformate --> benzaldehyde --> benzoate. These three steps are unique to mandelate oxidation; the benzoate formed is further metabolized via the beta-ketoadipate pathway. The first enzyme, l(+)-mandelate dehydrogenase, is induced by its substrate. The second and third enzymes, benzoylformate decarboxylase and benzaldehyde dehydrogenase, are both induced by benzoylformate. The same benzaldehyde dehydrogenase, or one very similar to it, is also induced by beta-ketoadipate, an intermediate in the subsequent metabolism of benzoate. This dehydrogenase may also be induced by adipate or a metabolite of adipate. These conclusions have been drawn from the physiological and genetic properties of wild-type P. aeruginosa strains and from the study of mutants lacking the second and third enzyme activities.


Polysaccharides of type 6 Klebsiella.

Polysaccharides of type 6 Klebsiella. Water-extractable type 6 Klebsiella antigens were separated into a type 6-specific acidic polysaccharide and a neutral polysaccharide. The neutral polymer was devoid of type 6 activity although it was serologically active. The type 6-specific polymer contained fucose, glucose, and mannose, and pyruvic, galacturonic, and possibly glucuronic acids. The neutral polymer contained glucose, galactose, and mannose.


Division mutants of Bacillus subtilis: isolation and PBS1 transduction of division-specific markers. A procedure for the isolation of Bacillus subtilis mutants that appear to be defective in septum synthesis has been described. Fourteen mutants isolated with this technique were found to be located at four distinct loci on the B. subtilis chromosome. These have been designated divA, divB, divC, and divD. The four mutants in the divA group synthesize septa; however, they do so with a high frequency of error resulting in minicell production. Mapping data were obtained by scoring cotransduction frequencies using PBS1-transducing lysates. Thus, some of the genes apparently involved in septum synthesis and their order on the genome have been established. The results of a study by electron microscope of some of the mutants is also presented.


Genetics of the mandelate pathway in Pseudomonas aeruginosa. The linkage of genes governing synthesis of enzymes functional in the conversion of l(+)-mandelate to benzoate in Pseudomonas aeruginosa was studied. These genes were found to be linked in a fashion consistent with regulatory mechanisms known to govern synthesis of this inducible pathway. Surprisingly, linkage was also observed between the mandelate genes and those governing the synthesis of functionally related enzymes that participate in the catabolism of anthranilate and benzoate. These latter genes are grouped in at least three regulatory units. Some theoretical explanations for high intensity of linkage among functionally related genes whose expression is not induced by a common metabolite are discussed.


Mutants of Rhodospirrillum rubrum obtained after long-term anaerobic, dark growth. Rhodospirillum rubrum S(1) cells were grown for more than 100 generations under strict anaerobic, dark conditions in liquid medium with sodium pyruvate. During this time, growth became nonpigmented. When cells were streaked onto the surface of solid growth medium in anaerobic bottles and placed in the dark, a few light-red colonies developed, but the majority was nonpigmented. Mutants were obtained from colonies selected on the basis of pigmentation and bacteriochlorophyll a content. The growth, ultrastructure, and light reactivity of two mutants were examined. Mutant C synthesized bacteriochlorophyll a (7.2 mumoles per mg of protein), altered membrane structures, and chromatophores during dark growth. Examination of light-induced changes of the absorption spectrum of this mutant suggested that only an electron transport pathway, which included the low potential cytochrome-like pigment C428, could be detected. Mutant C grew anaerobically in the light, whereas mutant G1 was light sensitive and produced only trace amounts of bacteriochlorophyll a (0.6 mumole per ml of protein). Poorly pigmented G1 cells contained unusual membrane structures. When dark-grown G1 colonies were placed in the light, deep-red colored papillae developed in the nonpigmented colonies. During anaerobic, dark growth with sodium pyruvate, both C and G1 synthesized poly-beta-hydroxybutyrate and produced acetate, carbon dioxide, and hydrogen gas.


Morphologic studies on the spinal cord of Macaca cyclopis (Swinhoe).


Experimental infection of Anisakis larvae in Taiwan monkeys with results of examinations of marine fishes of Taiwan for the parasite.


Incorporation of radioactive macromolecular precursors into intact cells and osmotically stabilized "protoplasts" of Streptococcus faecalis. Growing "protoplasts" of Streptococcus faecalis were shown to incorporate newly administered radioactive precursors in the same manner as growing intact streptococci. No observable differences could be found between the size of the leucine precursor pools of the two cultures. The extent of turnover of protein and ribonucleic acid in both "protoplast" and streptococcal cultures appeared to be identical. Finally, the absolute rate of macromolecular biosynthesis was found to be equivalent whether determined on the basis of "new" or "old" label incorporation.


Caffeic acid metabolism by bacteria of the human gastrointestinal tract. The metabolism of caffeic acid, previously shown to be carried out by the intestinal microbiota of man and experimental animals, has now been examined in a number of bacteria isolated from human feces. It has been found that of the 12 organisms isolated none has the ability to catalyze more than one reaction of the series leading from caffeic acid to either m-hydroxyphenylpropionic acid or 4-ethylcatechol.


Factors neutralizing the bacteriocidal effect of lysolecithin.


Genetic aspects of the complement system.


Residues of DDE and PCB in eggs from herrring gull (Larus argentatus) and common gull (Larus canus) in Norway.


The infectivity of Theileria mutans, Eperythrozoon wenyoni and E. teganodes to sheep and of E. ovis to cattle.


Forane (compound 469): 2. Biochemical effects of repeated administration to animals, response to bleeding, and compatibility with epinephrine.


Forane (compound 469)). 3. Comparative effects of prolonged anaesthesia on mature beagle dogs and young rhesus monkeys.


Comparison of the immunosuppressive properties of two related dimethanesulfonates.


Evidence that protein is bound to the rapidly labelled RNA in polyribosomes in vivo.


Separation of rhesus monkey juveniles of the same sex.


Biogenesis of the crystalline inclusion of Bacillus thuringiensis during sporulation.


Tissue distribution of channel catfish virus.


Central nervous system actions of some synthetic tetrahydrocannabinol derivatives.


A rational basis for the treatment of gonorrhoea.


Measurement of  226 Ra in mice.

Measurement of  226 Ra in mice.


Measurement of radioactivity in body organs. Report of a panel of experts of the International Atomic Energy Agency.


Immunoglobulins in clinical chemistry.

Immunoglobulins in clinical chemistry.


Attempted replication of, and selective breeding for, instrumental conditioning of Drosophila melanogaster.


The effects of 13 days maternal separation on infant rhesus monkeys compared with those of shorter and repeated separations..


Significance of bound dye and glutathione for aminoazo dye hepatocarcinogenesis.


Bacteriophages of Bacillus subtilis: comparison of different isolation techniques and possible use for classification of Bacillus subtilis strains.


Amphetamine: a pharmacological profile.

Amphetamine: a pharmacological profile.


Galactose metabolism of mammalian erythrocytes.


Influence of culture pH on photo-inhibition of division in Euglena gracilis.


Two-step growth curve from undisturbed cultures of Tetrahymena pyriformis.


Synthesis of high molecular weight polyphosphate with a partially purified enzyme from Salmonella.


'Don't talk to me about permeability'. The tenth Marjory Stephenson memorial lecture.


Immunochemistry of the carbohydrate antigens of some Streptococcus salivarius strains.


Isolation of T-mycoplasmas from dogs and squirrel monkeys: biological and serological comparison with those isolated from man and cattle.


Macaque photopic spectral sensitivity.

Macaque photopic spectral sensitivity.


Spectral sensitivity of non-opponent cells in the lateral geniculate nucleus.


Experimentally induced amaurosis and amblyopia in monkey.


Immunologic analysis of Mycobacterium leprae antigens by means of diffusion-in-gel methods.


Two types of ciliary resorption.

Two types of ciliary resorption.


Role of transfer kinetosomes in the gemmation of Protozoa.


Immunoelectrophoresis of extracts from bovine corneal epithelium using antisera specific to individual protein fractions.


Demonstration of a tissue specific antigen in bovine corneal epithelium by immunodiffusion.


Ankylosing spondylitis. Report of one case studied with histology, tetracycline bone labelling, microradiography and scanning electron microscopy.


Degree of expression of the tox +  gene introduced into corynebacteria by phages derived from diphtheria bacilli having different capacities to produce toxin.


Fractionation of staphylococcal enterotoxin C 2 by isoelectric focusing.


Lipids of antibiotic-sensitive and -resistant strains of Pseudomonas aeruginosa.


Observations on the conversion of an inactive precursor protein to the antibiotic nisin.


Heterogeneity of staphylococcal enterotoxin B.


Purification and properties of a phenol carboxylic acid acyl esterase from Aspergillus flavus.


Simple excision or biopsy plus radiation therapy as the primary treatment for potentially curable cancer of the breast.


The response of the toad intestine to prolonged starvation: a morphological, functional and metabolic study.


Effects of low- and high-LET cyclotron-accelerated alpha-particles on longevity of Drosophila melanogaster.


Effects of nitrites on arterial collateral vessels of dogs.


Studies on the antigenic activities of yeasts. VII. The reaction between concanavalin A and the mannans isolated from five species of yeasts including two serotypes of Candida and Saccharomyces cerevisiae.


Enhancement of rubella virus replication in swine testicle cells by co-infection with hog cholera virus.


Difference in sensitivity of suppression of cellular DNA synthesis by ultraviolet-irradiated adenoviruses among three cell types.


Heat- and acid-labile virus-inhibiting factor or interferon induced by Rift Valley fever virus in mice.


Nuclear changes during ultraviolet light-induced depression of ribonucleic acid and protein synthesis in human epidermis.


Advances in medicine.

Advances in medicine.


Advances in the treatment of diabetes mellitus.


Antenatal detection of genetic enzyme defects.


Digenetic trematodes: quinone tanning system in eggshells.


The effect of fat on calcium absorption from a mixed meal in normal subjects, patients with malabsorptive disease, and patients with a partial gastrectomy. The absorption of (47)Ca Cl(2) taken with a milk and porridge meal was measured in normal subjects, patients with a partial gastrectomy, and patients with malabsorption. The addition of palm oil to the meal depressed calcium absorption, whereas the addition of medium-chain triglyceride had no effect. The contrasting effect of the two fats on calcium absorption was most marked in patients with a partial gastrectomy and least marked in patients with malabsorption. In patients with malabsorption, impairment of calcium absorption was most marked in the patients with a significant increase in faecal fat excretion. Absorption of calcium was greater in patients with a partial gastrectomy than in normal subjects.


Immunochemical isolation of vaccinia-virus antigens.


Enzymatic breakdown of Fab fragment by a cathepsin-rich subcellular fraction.


Enzymic and immunochemical properties of lysozyme. V. Derivatives modified at lysine residues by guanidination, acetylation, succinylation or maleylation.


Distribution of developing and mature Brugia malayi in Rhesus monkeys and in the jird, Meriones unguiculatus, after a single infection.


Eimeria palustris sp. n. and Isospora hammondi sp. n. (Coccidia: Eimeriidae) from the marsh rice rat, Oryzomys palustris (Harlan).


Morphology of the spores of Myxosoma cerebralis (Hofer, 1903) and M. cartilaginis (Hoffman, Putz, and Dunbar, 1965).


Two new Myxosporida, Henneguya gambusi sp. n. and Myxosoma pharyngeus sp. n., in the mosquitofish, Gambusia affinis (Baird and Girard).


Trichospirurosis in South American monkeys.


Pathology of liver transplantation.

Pathology of liver transplantation.


[Epidemiologic features of diphtheria from 1963 to 1969 in the Kirovograd region].


Waste stabilization ponds.

Waste stabilization ponds.


Vascular effects of dihydrogenated ergot alkaloids. Comparative effects of dihydroergostine and dihydroergotamine on the blood flow and the capacitance vessels in the human calf studied by plethysmography.


Urinary phenolic compounds in gnotobiotic and conventional rats on a free diet, and before and after L-DOPA loading on a milk diet.


Estimation of the albumin binding capacity in Rh immunization. Practical and theoretical interest. Personal experience.


Developmental malformations induced by cadmium. A study of timed injections during embryogenesis.


Fetal growth retardation produced by experimental placental insufficiency in the rhesus monkey. II. Chemical composition of the brain, liver, muscle and carcass.


Subunit composition of DNA-dependent RNA polymerase of Anacystis nidulans.


Sterol biosynthesis in Euglena gracilis Z. Sterol precursors in light-grown and dark-grown Euglena gracilis Z.


The PCB story unfolds.

The PCB story unfolds.


Nitrofurantoin media for the isolation of Pseudomonas aeruginosa.


Characterization of nonfermentative nonfastidious gram negative bacteria encountered in medical bacteriology.


Papillosphincteroplasty: comments on the diagnosis of papillitis and presentation of a new technical procedure.


Studies on the physical linkage of antibiotic resistance markers to ribosomal RNA genes in Bacillus subtilis.


Sporozoite transmission and serial blood passage of Plasmodium vivax in squirrel monkeys (Saimiri sciureus).


Immunoglobulin levels in the Kaiapit and Upper Watut areas of New Guinea with special reference to the tropical splenomegaly syndrome.


A presumptive case of naturally occurring Plasmodium knowlesi malaria in man in Malaysia.


Progesterone levels in amniotic fluid and plasma from women. II. Levels during pregnancies complicated by Rh-immunization or hepatosis gravidarum.


Peptic ulcer in pregnancy. Report of two cases of surgically treated bleeding duodenal ulcer.


Regulation of the proteinase production in two strains of Aeromonas.


Immune precipitation of not cell-bound antigen of Mycoplasma pneumoniae.


Utilization of thymine, thymidine and TMP by Neisseria meningitidis. 2. Lack of enzymes for specific incorporation of exogenous thymine, thymidine and TMP into DNA.


IgA and IgM reacting with staphylococcal protein A.


Antigenic studies on Staphylococcus epidermidis.


A polysaccharide antigen of an anaerobic oral filamentous microorganism (Eubacterium saburreum) containing heptose and 0-acetyl as main constituents. 1. Isolation and chemical characterization of the antigen.


Influence of cultural milieu on the replication of pseudomonas bacteriophages.


Studies on the precipitinogenic relationships between different serotypes of M. avium and M. intracellulare.


Photodynamic action in Spirostomum ambiguum.


Identification of lactobacillus as the source of bacterial histidine decarboxylase in rat stomach.


The anatomy of the resonating mechanism in howling monkeys.


Goeldi's monkey Callimico goeldii Thomas 1904 preying on snakes.


Hydronephrosis of pregnancy: a naturally occurring disorder in non-human primates closely resembling that in man.


Observations on baboons, Papio anubis, in an arid region in Ethiopia.


Behaviour of the adult males in a troop of free-ranging Chacma baboons (Papio ursinus).


Social entrainment of the feeding behavior in monkeys.


Red cell and serum proteins of talapoin, patas and vervet monkeys.


An in vitro assay plate assembly for use in toxicity screening.


Separation of different serological activities associated with immunoglobulins from sera of rabbits immunized with rat erythrocytes.


Antibacterial activity of dihydro-1,3-oxazine derivatives condensed with aromatic rings in positions 5,6. 1. The antibacterial activity in vitro of dihydro-1,3-oxazine derivatives with aromatic rings condensed in positions 5, 6 was examined.2. Of more than thirty compounds examined, two (T 615 and T 638) showed marked activity against various strains of Mycobacterium tuberculosis at concentrations below 2 mug/ml.3. These two compounds also showed marked activity against Escherichia coli, Clostridium pneumoniae and Salmonella typhi.4. Both showed marked activity in vivo against tuberculosis produced in mice and guinea-pigs by various strains of Mycobacterium such as human strain ;Sz', bovine ;An 5' and H37Rv non-resistant and resistant to isonicotinic acid hydrazide (INH), streptomycin (SM) and p-aminosalicylic acid (PAS).


Density distribution of red cells infected by Plasmodium knowlesi and plasmodium coatneyi.


Echinostoma lindoense: larval antigens from the snail intermediate host, Biomphalaria glabrata.


Schistosoma mansoni: immunity in Macaca mulatta.


Alabama diphtheria outbreak, 1967.

Alabama diphtheria outbreak, 1967.


Mortality trends in carcinoma of the cervix uteri.


Lack of effect of immunosuppression on scrapie infection in mice.


Distribution of triatomine-transmitted trypanosomiasis in Colombia and new records of the bugs and infections.


Serum concentrations of  G,  A, and  M immunoglobulins in patients with carcinoma, melanoma, and sarcoma.


Tube feeding syndrome (protein intoxication), (a report of three cases).


The use of methohexitone in EEG studies on epileptic patients.


Transmission of microsporidian infection in the snail Indoplanorbis exustus in west Malaysia.


Metabolism of  131 I-fibrinogen in normal humans and monkeys.


Amyloidosis of the islets of Langerhans in a crab-eating monkey (Macaca fascicularis).


Ophthalmic lesions in non-human primates.


Streptococcal bacterial endocarditis in chickens. Associated lesions of the central nervous system.


Comparison of the effects of different carbohydrate administration on plasma free amino acids in relation to blood glucose and plasma insulin responses in abdominal surgery.


Studies on surface antigens on cultured cells.


Immunofluorescent detection of autoantibodies in the sera of acute infective hepatitis patients.


Autoantibodies in some bullous diseases.


Intercellular antibodies in a patient without clinical pemphigus.


Immunofluorescence studies of IgE in periodontal disease.


Flourescent antibody studies of pemphigus-like antibodies in burn sera.


The relative distribution of cytotoxic lymphocytes and of alloantibody-forming cells in albumin density gradients.


Environmental effects on Segregation-distorter in Drosophila melanogaster: irradiation of SD- 72  at the onset of spermatogenesis.


Apparent enzyme inhibition through enzyme-induction studies as a possible mode of action of certain cobalt compounds.


Collagen as a vitreous heterograft.

Collagen as a vitreous heterograft.


The use of proteic and enzymatic coatings and-or membranes for oxygenators.


Implantation of an artificial cornea employing full thickness onlay sclera and a sliding conjunctival graft.


WHO Expert Committee on Yellow Fever. Third report.


Some properties of WY 22811, a new analgesic compound.


Pharmacology of bovine pulmonary vein anaphylaxis in vitro. 1. The bovine pulmonary vein contracts in response to acetylcholine, histamine, 5-hydroxytryptamine and bradykinin. The tissue is particularly sensitive to 5-hydroxytryptamine (>0.1 ng/ml). Specific Schultz-Dale reactions were elicited in the pulmonary vein in response to horse plasma.2. The Schultz-Dale reaction is inhibited both by antihistaminics and by the anti-5-hydroxytryptamine agent methysergide, but not by atropine.3. Sodium meclofenamate inhibited anaphylactic contraction but showed a strong tendency to antagonize many agonists indiscriminately.4. Disodium cromoglycate (DSCG: 100 mug/ml) which inhibits some immunological reactions of mast cells, and diethylcarbamazine citrate (DECC: 50 mug/ml) which inhibits slow-reacting substance of anaphylaxis (SRS-A) elaboration, each inhibited anaphylaxis incompletely (50% or less). However, a combination of DSCG and DECC virtually abolished the Schultz-Dale reaction in this preparation. It is tentatively suggested that the component of the anaphylactic contraction which is resistant to cromoglycate but sensitive to diethylcarbamazine could be due to SRS-A.5. The bovine pulmonary Schultz-Dale reaction appears to be a complex interaction of histamine, 5-hydroxytryptamine, SRS-A and possible other agents including kinins.


Stimulation of rabbit lymphocytes in vitro by a protozoan factor.


A chromosomal analysis of x-ray induced genetic variance of wing length in Drosophila melanogaster.


Biological and physical properties of a human  m-cryoglobulin and its monomer subunit.


Circulating antibodies in human favus.

Circulating antibodies in human favus.


Metabolism of radio-iodinated IgG in patients with abnormal IgG levels. I. Hypergamma-globulinaemia.


DNA biosynthesis.

DNA biosynthesis.


Protein synthesis by ribosomes from eggs of normal and thiotepa-chemosterilized house flies.


Biochemical aspects of oögenesis in Drosophila melanogaster.


Ultrastructure and contractures of the pigeon iris striated muscle. 1. The ultrastructure of adult pigeon iris muscle fibres has been described with emphasis on the distribution of the sarcoplasmic reticulum (SR). Contractures due to superfusion with solutions of different [K(+)] (3-150 mM) and acetylcholine (ACh) and their modification by alteration of external [Ca(2+)] and [Mg(2+)] were studied in isolated pigeon iris.2. The arrangement of the contractile myofilaments was like that of vertebrate skeletal fibres. The SR is well developed in the I-band and sparse at the A-band level. Tubular elements (T-system) which form triads with the SR were seen at all levels of the sarcomere though usually adjacent to the A-I junction.3. K(+) contractures developed monotonically to a steady level which was maintained for the duration of the high [K(+)] superfusion. The response to a standard [K(+)] stepwise change was not altered by conditioning the preparation with various [K(+)].4. Decreasing external [Ca(2+)] from 20 mM to Ca(2+)-free (i.e. no Ca(2+) added), enhanced iris contractures at all [K(+)] and in ACh enriched solutions. The K(+) response was abolished when the iris was superfused with Ca(2+) free solution plus EDTA (2 mM) for 45 min. Increasing [Mg(2+)] had little or no effect on iris contracture.5. Reducing external [Ca(2+)] from 3 to 0.3 mM caused a reduction of 3-7 mV in resting membrane potential and an increase from 3 to 10 mM-Ca(2+) caused 3 to 7 mV membrane hyperpolarization. Muscle fibre input resistance was not affected.6. It is concluded that in the pigeon iris, Ca(2+) required for contractile activation is obtained from internal stores, that membrane potential determines the degree of contractile activation and that the maintenance of the contracture is dependent on the failure of the Ca(2+) releasing mechanism to inactive. In addition, it is speculated that because the iris muscle has only sparse SR at the A-band level of the sarcomere, there may be slow Ca(2+) reaccumulation.


Mast cells and mast cell-sensitizing (homocytotropic) antibodies.


Tissue-specific patterns of histones and non-histone acid-soluble proteins in rat liver and brain nucleoprotein.


Isolation of 2-demethylphytylplastoquinone from Euglena gracilis.


Conjugates of phenylacetic acid with taurine and other amino acids in various species.


Propionate resistance in blue-green algae.


The intracellular localization of glycollate oxidoreductase in Euglena gracilis. 1. Lowering of the concentration of carbon dioxide in air available to phototrophically growing Euglena cultures from 5% to the normal value (0.03%) resulted in an increased specific activity of glycollate oxidoreductase. 2. The effects of chloramphenicol and cycloheximide suggested that this increase in activity was due to enzyme synthesis de novo on cytoplasmic ribosomes. 3. The K(m) for glycollate oxidation by the enzyme in crude cell extracts was 3.0x10(-3)m. 4. Differential centrifugation established that glycollate oxidoreductase present in phototrophically grown Euglena is a particulate enzyme. The enzyme was partially solubilized by the non-ionic detergent Triton X-100. 5. Sucrose-density-gradient centrifugation achieved the separation of the particulate glycollate oxidoreductase from chloroplasts and mitochondria. 6. Glutamate-glyoxylate aminotransferase was associated with particulate glycollate oxidoreductase.


Induction of cyst coat protein synthesis by starvation in the ciliate Colpoda steinii. 1. At 28 degrees C, synthesis of protein cyst coat in ciliates of Colpoda steinii is induced by washing with water and, as judged by glutamic acid assays and incorporation studies with l-[U-(14)C]leucine, starts about 30min after the cells have stopped swimming and is largely complete 90min later. During this time up to 70% of the protein synthesized by the cell is coat protein. 2. When cells were placed in l-[U-(14)C]leucine at low concentrations (0.25-0.76mm) during the period of coat synthesis there was no lag in uptake. Only a small proportion of the leucine incorporated into the coat was from the external substrate, implying that the rate of radioactive isotope incorporation measured the rate of transport of amino acid into the cell. Transport of l-[U-(14)C]leucine into the cell was markedly stimulated by l-glutamic acid and l-lysine. 3. When cells were placed in l-[U-(14)C]leucine at high concentrations (38mm) the rate of incorporation was considered to measure the rate of protein synthesis, but because the latter may have been affected by substrate it is concluded that such measurements are of doubtful value.


Lipoxygenase from potato tubers. Partial purification and properties of an enzyme that specifically oxygenates the 9-position of linoleic acid. A lipoxygenase (EC 1.13.1.13) was partially purified from potato tubers and was shown to differ from previously characterized soya-bean lipoxygenases in the positional specificity and pH characteristics of the oxygenation reaction. The potato enzyme converted linoleic acid almost exclusively (95%) into 9-d-hydroperoxyoctadeca-trans-10,cis-12-dienoic acid. The 13-hydroperoxy isomer was only a minor product (5%). Linolenic acid was an equally effective substrate, which was also oxygenated specifically at the 9-position. The enzyme had a pH optimum at 5.5-6.0 and was inactive at pH9.0. A half-maximal velocity was obtained at a linoleic acid concentration of 0.1mm. No inhibition was observed with EDTA (1mm) and cyanide (1mm) or with p-chloromercuribenzoate (0.2mm). Haemoproteins were not involved in the lipoxygenase activity. The molecular weight of the enzyme was estimated from gel filtration to be approx. 10(5). Preliminary evidence suggested that the enzyme oxygenated the n-10 position of fatty acids containing a penta(n-3, n-6)diene structure.


The interrelation of phosphatidylethanolamine and glycosyl diglycerides in bacterial membranes.


Regeneration, duplication and transdetermination in fragments of the leg disc of Drosophila melanogaster.


The pattern of replication of cortical units in Tetrahymena.


Synthesis of 3'.4'-dideoxyneamine active aginst kanamycin-resistant E. coli and P. aeruginosa.


Enzymatic inactivation of gentamicin C components by cell-free extract from Klebsiella pneumoniae.


Development of isometric tension in simian extraocular muscle. 1. Isometric tension resulting from electrical stimulation of the abducens nerve was measured in the lateral rectus muscle of anaesthetized monkeys.2. The lateral rectus showed no increase in maximum tension at stimulus frequencies greater than 400/sec.3. However, at frequencies between 400 and 600/sec, the rate of change of tension increased so that maximum tension was achieved more rapidly.4. Rates greater than 600/sec caused no further increases in the rate of change of tension and actually resulted in a decrease of maximum tension.5. Since, in addition, single fibre recordings from ocular motor nerves reveal maximum discharge rates of less than 600/sec, units in the abducens nucleus that fire at greater than 600/sec are likely interneurones.6. Stimulation at rates of 30/sec, the frequency at which feline slow or slow twitch fibres produce fused contraction, produced no measurable tonic component of tension. Therefore, the force contributed by slow muscle fibres probably plays an insignificant role during eye movements.


The effect of metal ions and antidiuretic hormone on oxygen consumption in toad bladder. 1. The sodium-dependent oxygen consumption of pieces of toad bladder (Bufo marinus) has been investigated using an oxygen electrode.2. The effect of polyvalent cations (Ca(2+), Sr(2+), Mg(2+), Eu(3+), La(3+) and Mn(2+)) on sodium-dependent oxygen consumption has been measured. All cations inhibited oxygen consumption, the order of effectiveness being Ca(2+) > Sr(2+) > Mg(2+) > Mn(2+) > Eu(3+) > La(3+).3. Treatment of bladder pieces with antidiuretic hormone (50 m-u./ml.) decreased the effectiveness of Ca(2+) and Sr(2+) as inhibitors of sodium-dependent oxygen consumption. Mn(2+), Eu(2+) and La(2+) were more effective after hormonal treatment, while the effectiveness of Mg(2+) was unaltered.4. The results have been interpreted in terms of a model in which sodium entry to the transporting mechanisms of the epithelium is controlled by Ca(2+), and in which antidiuretic hormone alters Ca(2+) binding and so affects sodium transport.


Survivor curves of selected Salmonella enteritidis serotypes in liquid whole egg homogenates at 60oC.


Preparation of human cells for the assay of serum fibrinogen degradation products using haemagglutination inhibition.


"Fibrinogen Amsterdam" another hereditary abnormality of fibrinogen.


Comparison of the Tanned Red Cell Hemagglutination Inhibition Immuno-assay and radial immunodiffusion for the quantitation of fibrinogen-related antigen in urine concentrates.


A sensitive and rapid quantitive determination of fibrin split products in serum.


Immunochemistry of Mycococcus and its position within actinomycetales.


Genetic organization in Drosophila melanogaster: complementation and fine structure analysis of the deep orange locus.


Aberrant sex ratios among the tumorous-head strains of Drosophila melanogaster.


Heat-induced exchange in the fourth chromosome of diploid females of Drosophila melanogaster.


Competition in drosophila. I. A case of stabilising selection.


A clinico epidemiological study of animal bites with reference to rabies.


Total serum thyroxine in thyroidectomized beagles, using  125 I-labeled thyroxine, and comparison of T-3 and T-4 tests.


Human skin--antibacterial in vitro?

Human skin--antibacterial in vitro?


Neurofibromatosis and leprosy.

Neurofibromatosis and leprosy. Two patients with neurofibromatosis and leprosy are reported. Both had active lepromatous leprosy and generalized neurofibromata. The bacilli appear in huge numbers within the cytoplasm of the cells making up the neurofibromata, which become distended and resemble lepra cells. Since these cells are believed to derive from Schwann cells, the findings in these patients support the idea that leprosy affects nerves initially by proliferating in Schwann cells and producing changes within them.


Fructose in medicine. A review with particular reference to diabetes mellitus.


A redescription of Mesocoelium monas (Rudolphi, 1819) Freitas, 1958, and specific determination in genus Mesocoelium Odhner 1910 (Trematoda, Digenea).


Active chronic hepatitis and haemolytic anaemia associated with Rh-specific antibodies.


Methods and problems associated with the routine preparation of anti-Rh immunoglobulin.


The future of Rh immune globulin.

The future of Rh immune globulin.


Some epidemiological aspects of the prevention of Rh isoimmunization.


Some residual problems concerning Rh prophylaxis.


Prevention of Rh immunization: some failures and the possibility of overcoming them.


Will some cases of Rh immunization occur despite administration of adequate amounts of anti-Rh o (D) IgG?


Incidence of Rh immunization in primigravidae and risk of immunization in multiparae.


A new assay for Rh o (D) immunoglobulin by measuring rosette-forming antibodies. Quantitative studies on rosette-forming antibodies in Rh o (D) immunoglobulin.


Successful prophylaxis of Rh immunization using small doses of intravenous anti-D IgG.


Thoughts and questions on the role of the D u  factor in Rh prophylaxis.


Cellular events involved in middle ear fluid production.


Circular-dichroism studies on two  -lactamases from Bacillus cereus. The circular-dichroism (CD) spectra of beta-lactamases I and II from Bacillus cereus 569/H are reported, along with that of the beta-lactamase II free from carbohydrate. The results show that carbohydrate makes an appreciable contribution to the optical activity of beta-lactamase II in the far-ultraviolet, and that removal of carbohydrate greatly affects the optical activity of several aromatic side chains of the protein moiety. Both tyrosyl and tryptophanyl residues are affected, showing that some of these residues must be near to the surface of the protein moiety, close to the site of attachment of the carbohydrate. Although the far-ultraviolet CD spectrum of beta-lactamase II resembles that of a protein containing some beta-structure, it can be shown that this is a consequence of the optical activity of carbohydrate in this region of the spectrum, and that the protein is likely to contain alpha-helix rather than beta-pleated sheet structure. The overall structures of the protein components of beta-lactamases I and II are similar, but not identical, as shown by the dissimilarity of the CD spectra when calculated on a mean residue basis.


Pteroylglutamate derivatives in Pisum sativum L. Biosynthesis of cotyledonary tetrahydropteroylglutamates during germination. 1. The concentrations of pteroylglutamate derivatives in the cotyledons of pea (Pisum sativum L.) seedlings were determined by microbiological assay by using Lactobacillus casei (A.T.C.C. 7469), Streptococcus faecalis (A.T.C.C. 8043) and Pediococcus cerevisiae (A.T.C.C. 8081). During germination the pteroylglutamate content of the cotyledons increased rapidly from 0.2mug/g dry wt. to 4.0mug/g dry wt., the maximum values being reached approx. 120h after imbibition. 2. Approx. 50% of the pteroylglutamate pool of 3-day-old seedlings was accounted for by highly conjugated derivatives. The concentrations of such derivatives were greatest when precautions were taken to inactivate endogenous enzymes before extraction of the tissues. 3. Individual derivatives present in the tissue extracts were separated by chromatography on DEAE-cellulose. Synthesis of the major derivative, 5-methyltetrahydropteroylmonoglutamate, was inhibited by administration of 0.1mm-aminopterin and -amethopterin solutions during imbibition. Under these conditions pteroylglutamic acid accumulated in the tissues. 4. Feeding experiments employing [2-(14)C]pteroylglutamic acid and 5[(14)C]-methyltetrahydro-pteroylmonoglutamic acid revealed that both compounds were incorporated into conjugated and unconjugated derivatives of the pteroylglutamate pool.


Effect of electrolytes and of distilled water on antigen-antibody complexes. Specific immune precipitates dissolve in concentrated solutions of alkali-metal halides, and of alkaline-earth-metal halides and thiocyanates. The quantity of protein dissolved depends on the nature of the antigen-antibody system, on the proportion of the antigen in the precipitate, and on the avidity of the antibody. The extent of solubilization is a function of the temperature, of the volume of solution used and of the concentration of the ions in the solution, and also depends on the nature of these ions. The dissolving power of bivalent cations is greater than that of monovalent ones, and is as follows: Mg(2+)[unk]Ba(2+)[unk]Ca(2+)[unk]Sr(2+). Antigen-antibody complexes and free antibodies, but no free antigen, are detected in supernatants of specific precipitates dissolved in solutions of electrolytes of low ionic strength. Antigen-antibody complexes, free antibodies and also free antigen are detected in supernatants of specific precipitates dissolved in solutions of electrolytes of high ionic strength. Comparable results are obtained when the electrolyte solutions are studied for their effect on the bonds formed between an antibody and its corresponding immunosorbent. Moreover, in the latter case, 50% of the fixed antibodies could be recovered by elution with distilled water.


Studies on antigen-antibody reaction in the kidney caused by anti-placental serum in pregnant and puerperal rabbits. 1. Light microscopic studies on renal changes.


RNA metabolism during puff induction in Drosophila melanogaster.


India and the yellow fever problem.

India and the yellow fever problem.


Immunofluorescent localization of trypsin-like esteropeptidases in the mouse submandibular gland.


Isolation of a virus belonging to the Phlebotomus fever virus group from febrile cases in Aurangabad.


A study of immunity status against diphtheria among children below five years in a rural population in Lucknow district.


Sanguinarine potentiating factor in argemone oil.


Evidence of qualitative differences in learning processes among primates.


Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens.


The evolution of spastic paraplegia following cortical ablation in infant monkeys.


Differential recovery of proximal and distal motor power after cortical lesions.


Spinal cord blood flow compartments.

Spinal cord blood flow compartments.


Visna virus: a "slow" neurotropic agent with tumor virus properties.


The three-dimensional appearance of regional specialization in the ventricular walls: a scanning electron microscopic study.


A fluorescence histochemical survey of monoaminergic innervation of cerebral blood vessels in primate and humans.


Evidence for cyclic development and short-lived maturity in the gametocytes of Plasmodium falciparum.


The effects of some immunosuppressive agents in experimental chronic Chagas's disease.


Anopheles elegans, a natural vector of simian malaria in Ceylon.


The use of a fibre-optic system in malarial immunofluorescence tests.


Some characteristics of pectolytic bacteria associated with potato in Tasmania.


Bacteria and actinomycetes antagonistic to fungal root pathogens in Australian soils.


Antiepileptic and psychotropic effect of carbamazepine (Tegretol) in the treatment of psychomotor epilepsy.


Clinical applications of the agar culture technique for haemopoietic cells.


Pseudomonas aeruginosa with exceptionally high resistance to gentamicin in hospital wards. Susceptibility and phage typing.


Quantitation of immunoglobulins in biological fluids by electro-immunodiffusion.


Separation and properties of isozymes of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthetase from Saccharomyces cerevisiae.


Kinetics of transport of glucose, fructose, and mannitol by Pseudomonas aeruginosa.


Interspecies correlation of plasma concentration history of methotrexate (NSC-740).


The "sensitivity" of resting and dividing cells.


Improved microbiological assay for cytosine arabinoside (NSC-63878).


Virus hepatitis of geese. II. Host range of goose hepatitis virus.


Calcium transport in Bacillus megaterium.


X-linked hypogammaglobulinemia. Additional observations in a previously reported family.


The effect of the immunosuppressive agent cyclophosphamide on IgG levels and parasite number in experimental trypanosomiasis.


Preliminary histopathological study of a new quartz-filled composite dental restorative material.


Evaluation and testing of drugs for mutagenicity: principles and problems. Report of a WHO Scientific Group.


Antibacterial activity of dental restorative materials.


Particulate nature of glycolate dehydrogenase in euglena: possible localization in microbodies.


Response of the primate dental pulp to a concentrated stannous fluoride solution.


Activity of a new synthetic tetrapeptide in hypothalamic luteinizing and follicle stimulating releasing hormone assay systems.


On the structure of the hypothalamic luteinizing releasing hormone. Evidence for the presence of arginine, tyrosine, and tryptophan by inactivation.


Studies on plasma membranes. 13. Co 2+ -activated aminopeptidase(s) in the globular units locally coating rat-liver plasma membranes.


Acetic acid as a solvent for erythrocyte membrane proteins.


The control of membrane-bound Ca 2+  by ATP.


Incorporation of penicillinase into reaggregated mycoplasma membranes.


Langmuir adsorption behavior with cation-induced voltages across bimolecular lipid membranes.


Inhibition of cilia regeneration by antineoplastic agents.


Microbiological assay for cytosine arabinoside (NSC-63878) in biologic materials containing other antitumor or antibacterial drugs.


Initial clinical trial of dibromodulcitol (NSC-104800) in patients with advanced cancer.


Pharmacological comparison of prostaglandin F 2a' serotonin and norepinephrine on cerebrovascular tone of monkey.


Amplifying and suppressive effect of thymus cells.


Isolation and characterization of the basic, diagnostic IgG globulin in the rare gammopathy, papular mucinosis.


Crystalline thymidylate synthetase from dichloromethotrexate resistant Lactobacillus casei.


Studies on the structure of thyrotropin: its relationship to luteinizing hormone.


Spontaneous hyperglycemia and-or obesity in laboratory rodents: an example of the possible usefulness of animal disease models with both genetic and environmental components.


Use of antibodies for characterization of gonadotropins and steroids.


Hyperexcretion of cathecholamines induced by indomethacine.


Observations on nerve cells in human, mammalian and avian cardiac ventricles.


Human secretory immunoglobulins. VII. Concentrations of parotid IgA and other secretory proteins in relation to the rate of flow and duration of secretory stimulus.


Studies on production and some properties of antiserum against erythropoietin.


Cholesterol ester content of the serum: alterations due to simple and complex carbohydrate diets in nonhuman primates (Cebus albifrons, Macaca arctoides, and Macaca mulatta).


Pyrogen and enzyme release from rabbit blood leukocytes promoted by endotoxin and polyinosinic polycytidylic acid.


Control of glucose phosphorylation in Euglena gracilis. I. Partial characterization of a glucokinase.


Electron microscope studies of gonococci in the urethral secretions of patients with gonorrhoea.


Single-dose oral treatment of gonorrhea in men and women, using ampicillin alone and combined with probenecid.


Total body potassium in protein calorie malnutrition.


Some observations on the effects of time curtailing on the parameters of decaying exponentials fitted to biomedical data.


Effects of brief separations from mothers during infancy on behaviour of rhesus monkeys 6-24 months later.


Nitroglycerol on the isolated ear artery of the rabbit.


Joint FAO-WHO Expert Committee on Nutrition. Eighth report. Geneva, 9-18 November 1970.


Enzymatic conversion of l-decene to decyl alcohol by Candida rugosa JF 101.


Denture stomatitis. IV. An experimental model in monkeys.


A rapid method for synchronization of Staphylococcus aureus and Bacillus subtilis.


Inactivation of L-lysine decarboxylase by L-lysine bromomethyl ketone.


Investigation of the mechanism of ligand binding with cobalt(II) human carbonic anhydrase by  1 H and  19 F nuclear magnetic resonance spectroscopy.


Studies on the mechanism of action of aldosterone: hormone-induced changes in lipid metabolism.


A study of the breakdown of carbohydrate by redox-generated free radicals.


Properties of a CMP-N-acetylneuraminic acid: glycoprotein sialyltransferase in human serum and erythrocyte membranes.


Studies in valine biosynthesis. IX. The enzymes in photosynthetic and autotrophic bacteria.


The universal prevention of Rh immunization.


Care of the mother of the high-risk infant.


Visual discrimination performance in the monkey: the effect of unilateral removals of temporal cortex.


The anatomical organization of the suprasylvian gyrus of the cat.


The measurement of the value of the clinical process to individuals by age and income.


Clinical studies on apexcardiogram. II. Cardiac movement in thyroid dysfunction and coronary heart disease from the point of apexcardiogram.


Clinical studies on apexcardiogram. 3. Effects of low oxygen inhalation and various pharmacological tests on the apex beat in cardiac patients.


Neuroendocrine control of the pituitary TSH secretion. IV. Biological action of synthetic thyrotropin releasing factor (TRF) in vivo and in vitro.


Neuroendocrine control of the pituitary TSH secretion. V. Mode of action of synthetic TRF with special reference to interaction between TRF and thyroxine.


Transsection of supraalveolar fibers on orthodontically rotated teeth in monkeys.


The postnatal growth of the cranial base in Macaca rhesus analyzed by the implant method.


Population genetic studies on carbonic anhydrase polymorphism of cattle.


Immunological study of rabbit cysticercosis. 3. The precipitin response to experimental infection with Cyscitercus pisiformis (Bloch 1780).


Modification of lincomycin.

Modification of lincomycin.


Effects of certain iron-chelators and antibiotics on the interaction of succinate dehydrogenase and cytochrome b in ubiquinone-depleted submitochondrial particles.


Intramitochondrial distribution of magnesium.


Effect of anions on chloroplast particles.


Immunological studies on glycogen storage diseases type 3 and V. Demonstration of the presence of an immunoreactive protein in one case of muscle phosphorylase deficiency.


Chromosome-membrane association in Bacillus subtilis. I. DNA release from membrane fraction.


Ornithine transcarbamylase: steady-state kinetic properties.


Synergistic effects of a membrane protein (spectrin) and Ca 2+  on the Na +  permeability of phospholipid vesicles.


Further studies on the effect of aldosterone on glucose metabolism in toad bladder.


The effect of EDTA on the electrical activity of rat jejunum.


The methyl viologen-catalyzed Mehler reaction and catalase activity in blue-green algae and Chlamydomonas reinhardi.


Action of pure phospholipase A 2  and phospholipase C on human erythrocytes and ghosts.


Cytochrome c 3 . A class of electron transfer heme proteins found in both photosynthetic and sulfate-reducing bacteria.


The P700-chlorophyll  -protein of a blue-green alga.


Control of excitation transfer in photosynthesis. V. Correlation of membrane structure to regulation of excitation transfer between two pigment systems in isolated spinach chloroplasts.


Anomalies in polysome profiles caused by contamination of the gradients with Cu 2+  or Zn 2+ .


Evidence for cortical control of macronuclear behavior in Stentor.


An inhibitor of protein synthesis in cytoplasmic extracts of density inhibited cells.


Reversed-phase thin-layer chromatography and partition coefficients of penicillins.


Informofer-like protein in polyribosomes.


The effect of substrate analogues on the iodine sensitivity of penicillinase from B. cereus.


Effect of electrolytes on the activity and iodine sensitivity of penicillinase from B. cereus.


John Hunter, A.A. Berthold, and the origins of endocrinology.


I.R.I. after glucagon administration in groups of obese subjects, with no family history of diabetes, with normal glucose tolerance test, with chemical diabetes, or with mild not ketotic diabetes mellitus.


The ultrastructural aspect of A-cells of non-ketotic and ketotic diabetic animals: indications for stimulation and inhibition of glucagon production.


A hydrophobic protein from the cell envelope of Hydrogenomonas facilis.


Streptomycin biosynthesis. I. Existence of two amidinotransferase activities in Streptomyces griseus.


Pyruvate kinase isozymes in adult tissue and eggs of Rana pipiens. II. Physical and kinetic studies of purified skeletal and heart muscle pyruvate kinases.


3-Deoxy-D-arabino-heptulosonate-7-phosphate synthase of Streptomyces aureofaciens Tü 24. I. Partial purification and properties.


Purification, general properties and two other catalytic activities of  -ketoglutarate:glyoxylate carboligase of Mycobacterium Phlei.


3-D-eoxy-D-arabino-heptulosonate-7-phosphate synthase of Streptomyces aureofaciens Tü 24. II. Repression and inhibition by tryptophan and tryptophan analogues.


Physiopathology of Chagas' heart disease: correlations between clinical and experimental findings. In penetrating the heart and developing in it, Trypanosoma cruzi produces an immunoallergic reaction that leads to changes in the histological structure of the myocardium; these changes alter the fundamental properties of the heart, causing fundamental dynamic disorders and morphological changes in the organ.In Chagas' cardiomyopathy, the velocity of impulse propagation diminishes in the auricular and ventricular musculature, altering the activation mechanism, this being shown by changes in the P-wave and in ventricular focal blocks.The functional refractory period (FRP) is shortened in the auricular and ventricular tissue and constitutes, together with changes in conductivity, the physiopathological basis that explains the circus movement-the fundamental factor of the arrhythmias of this stage of the disease. Localization of the inflammation in the A-V conduction system increases the duration of the FRP, producing all types of A-V block.The oedema and the cellular interstitial infiltration seen during this acute phase reduce the distensibility of the fibres; this, in turn, limits their contractility, producing a decrease in systolic volume and an increase in the final diastolic pressure in the chambers of the heart-fundamental factors in reducing kinesia and in increasing the heart's volume.In the chronic phase, destruction of the contractile tissue and fibroblastic proliferation bring into play compensatory mechanisms that maintain the strength of cardiac contractions; the elongation of the fibres and the nature of the dynamic pressure-volume curves explain the dilatation of the chambers of the heart and the dynamic changes seen in this phase of the disease.


Bacteria in laundered fabrics.

Bacteria in laundered fabrics.


Measurements of concentrations of human serum immunoglobulins.


A limonin-degrading enzyme in citrus albedo.


Reduced incidence of x-ray induced leukemia after treatment with anti-lymphocyte serum.


Annealing studies of transcription in B. Subtilis.


Comparative cytological studies of the carotid body. 1. Demonstration of monoamine-storing cells by correlated chromaffin reaction and fluorescence histochemistry.


A simple outfit for the detection of bacteriuria.


An evaluation of the heat precipitation method for plasma fibrinogen estimation. A rapid heat precipitation micromethod for the estimation of plasma fibrinogen is described. Its validity and reproducibility have been extensively tested. The method correlates well with a more generally used thrombin-clotting technique over a wide range of fibrinogen levels.


Differences in chemical nature of the endotoxins derived from Pseudomonas aerugiuosa, strain P1-3.


2,4-Diamino-6-arylethylpteridines as Streptococcus faecium growth inhibitors.


A method of obtaining a pure fluid culture of dissociant strain of Pseudomonas aeruginosa, strain N 10.


A lytic enzyme(s) acting on Lactobacilli.


Specific establishment of lactobacilli in the digestive tract of germ-free chickens.


Mercury derivatives of the Fab and Fc fragments of a human myeloma protein.


Structure studies on chromatin and nucleohistones. Thermal denaturation profiles recorded in the presence of urea.


Public welfare and family planning.

Public welfare and family planning.


A purine and pyrimidine requiring mutant of Drosophila melanogaster.


Spirochaete-mediated abnormal sex-ratio (SR) condition in Drosophila: a second virus associated with spirochaetes and its use in the study of the SR condition.


An estimate of heterosis in Drosophila melanogaster.


Treatment of joint injuries by immediate mobilization. Based upon the spinal adaptation concept.


Influence of some nitrofurans on carcinogenesis in rats fed 4-(dimethylamino) azobenzene.


Plaque characteristics of coxsackie A7 virus.


Innervation of the nasopharynx in Macaca fascicularis.


Limits in tuberculosis chemotherapy as revealed by experimental study in mice.


The need for a standardised cell substrate for virus vaccine production.


Suggested criteria for the acceptability of a passaged diploid cell population as substrate for virus vaccine production.


Cortical focal epilepsy in child. Electro-clinical correlations.


The use of cannabis. Report of a WHO scientific group.


Personal health care and social security. Report of a joint ILO-WHO committee.


Thianosine, an antibiotic produced by Bacillus thiaminolyticus.


Production of monkey antiserum against mouse growth hormone.


Purification of human placental lactogen and its clinical application by single radial immunodiffusion.


Influence of preimaginal environment on fecundity and ageing in Drosophila melanogaster hybrids. 3. Developmental speed and life-span.


Influence of preimaginal environment on fecundity and ageing in Drosophila melanogaster hybrids. II. Preimaginal temperature.


Renal erythropoietic factor (REF) assays in anephric and intact baboons following varied erythropoietic stimuli. A preliminary report.


Photodynamic mutagenic activity of riboflavin for transforming deoxyribonucleic acid and accelerative effect of adenine.


Recognition and management of common sprains in athletes.


Experimental granulomatous myocarditis: genesis and immunological aspects.


Action of nalidixic acid and hydroxyurea on two blue-green algae.


Biochemical analysis of bacterial macromutations.


A kinetic study of microencapsulated bovine carbonic anhydrase.


Involvement of tyrosine in the binding of carcinogenic aminoazo dyes to rat-liver proteins in vivo.


Two specific azodye-carcinogen-binding proteins of the rat liver. The identity of amino acid residues which bind the azodye.


Iron(3)-exchange between transferrin and chelates in vitro.


Cytotoxic and mutagenic activation of urethane by N-hydroxylation and O-esterification.


Mitotic responses to partial hepatectomy in preneoplastic rat liver.


Recent advances in the pharmacology of tetrahydrocannabinols.


Retention of oral  47 calcium in acromegaly.


Glybenclamid (HB 419) and the prediabetes of subtotally pancreatectomized rats.


Bacteriological diagnosis of pulmonary tuberculosis. A comparative study of gastric wash, laryngeal swab and lung puncture.


Elevated serum IgA globulin in anaphylactoid purpura.


Treatment of cyanide poisoning.

Treatment of cyanide poisoning.


Insulin treatment of diabetes mellitus.

Insulin treatment of diabetes mellitus.


Diabetic ketoacidosis.

Diabetic ketoacidosis.


Non-ketotic coma and diabetes mellitus.

Non-ketotic coma and diabetes mellitus.


Infections and diabetes.

Infections and diabetes.


Obstetrical management of the pregnant diabetic.


Intestinal lactase deficiency in adult nonhuman primates: implications for selection pressures in man.


Role of acetyl coenzyme A carboxylase in the control of fatty acid synthesis.


The integrity of the 25-S ribosomal RNA from Euglena gracilis 87-S ribosomes.


Enhanced DNA uptake and transfection in Escherichia coli cells grown in low-phosphate medium.


Protein content and biological activity of ribosomal particles from ascites carcinoma Krebs II cells.


The amino acid sequence of Streptomyces griseus protease A: the peptic peptides.


The purification and some properties of soluble trehalase and sucrase from Drosophila melanogaster.


On the diagnostic and prognostic value of the bromsulphthalein test in patients with hepatic cirrhosis.


Dynamics of heart contraction in chronic cor pulmonale with heart failure II-a Degree before and after treatment as revealed through phase analysis of the mechanical systole.


Characteristics of the atherosclerotic changes in the aorta and the coronary arteries in rheumatic fever. (Morphometric investigation).


Changes in the level of TSH under the influence of ultrasound energy.


Our first saprophytic leptospiral strains antigen analysis. 3d communication.


Histologic and some histochemical changes of the lumbar intervertebral discs in patients with discogenic sciatica.


Diabetic acidosis and emotional stress. A case report.


Immunogenicity of a toxoid of Habu (Trimeresurus flavoviridis) venom in various animal species including man.


Bacillary dysentery in cynomolgus monkeys following the administration with Shigella flexneri 2A by the anal route.


Cytogenetics of nucleolus-rranspositions in Drosophila melanogaster.


Genetic analysis of a meiotic mutant resulting in precocious sister-centromere separation in Drosophila melanogaster.


Molecular heterozygotes in Bacillus subtilis and their correction.


Modified Sauton medium for Tuberculin production.


Quantitation of red cell and heme production and destruction using radioisotope kinetics.


Drosophila cell culture and its application for the study of genetics and virology. I. Drosophila cells in vitro: behavior and utilization for genetic purpose.


II. Established diploid cell lines of Drosophila melanogaster as potential material for the study of genetics of somatic cells.


3. Arbovirus multiplication in an established diploid cell line of Drosophila melanogaster.


V. The SR condition in Drosophila bifasciata: in vivo and in vitro growth.


IV. Characterization and identification of insect cell cultures.


II. Drosophila neuron differentiation in vitro.


VI. Comparative lipid analysis of Aedes aegypti and monkey kidney cells (MK-2) cultivated in vitro.


The cytochemistry of hypotrichous-ciliates Onychodromus and Euplotes.


Auditory generalization gradients for response latency in the monkey. Two monkeys were trained to press and hold a response key in the presence of a light and to release it at the onset of a pure tone. Initially, all responses with latencies shorter than 1 sec were reinforced without regard to the frequency of the pure tone, and the intensity of the pure tone that resulted in equal latencies at each frequency was determined. The second stage of the experiment consisted of discrimination training, during which releases to one pure-tone frequency (positive stimulus) were reinforced and releases to a second frequency (negative stimulus) were extinguished. Median latencies to the negative stimulus slowly increased as did the variability of the latency distribution for the negative stimulus. There was no evidence of a concurrent decrease in latencies to the positive stimulus indicative of behavioral contrast. The third part of the experiment consisted of determining maintained generalization gradients by increasing the number of nonreinforcement stimuli. The gradients that eventually resulted showed approximately equal latencies to all frequencies of the negative stimulus and shorter latencies to the positive stimulus frequency.


Cytochemical and biochemical demonstration of an alkaline phosphatase in human red cells.


Lankesterella alencari n. sp., a Toxoplasma-like organism in the central nervous system of Amphibia (Protozoa, Sporozoa).


The impact of national health insurance on delivery of health care.


Comparative treatment technologies and health care patterns in institutions for mentally retarded.


Structure of the peptidoglycan from vegetative cell walls of Bacillus subtilis.


Further studies of the lipid composition and biochemical properties of Tetrahymena pyriformis membrane systems.


Lactobacillus plantarum exoribonuclease. Further purification and characterization.


Lactobacillus plantarum exoribonuclease. Effect of urea treatment on the processive mode of degradation.


Studies on the role of calcium in thermolysin.


Rare earth metal ions as substitutes for the calcium ion in Bacillus subtilis  -amylase.


Development and complementation of lethal mutations at the dumpy locus of Drosophila melanogaster.


Characterization of the reactive sulfhydryl groups in carbamyl phosphate synthetase of Escherichia coli.


The physiological control of gene action in the eyeless and eyegone mutants of Drosophila melanogaster.


Metabolism of the schistosomicidal agent hycanthone by rats and rhesus monkeys. The absorption, distribution, and excretion of hycanthone were studied with rats and rhesus monkeys using tritiated materials at the therapeutic dose recommended for man (3.0+/-0.5 mg/kg). Nine pairs of each species received single intramuscular doses of randomly tritiated (specific activity 193.7 mCi/mmol) hycanthone methanesulfonate and were then sacrificed at intervals between 15 min and 72 h after medication. Peak blood and tissue concentrations occurred 30-60 min after administration (plasma half-life-45 min). The highest concentrations were observed in the liver, spleen, kidneys and adrenals, but decreased rapidly (more than 80% of the dose was excreted in 48-72 hours). In monkeys a high concentration of the compound was found in the bile (hours 1-8), probably conjugated to glucuronic acid.Radiochromatography showed only unchanged drug in the blood and tissues, except in the liver where rapid conversion occurred to sulfoxide in the rat and to the deethyl analogue in the monkey.


Effective protection of monkeys against death from street virus by post-exposure administration of tissue-culture rabies vaccine. Three series of experiments on rabies vaccines were carried out on rhesus monkeys using suckling-mouse-brain vaccine, rabbit-brain vaccine, duck-embryo vaccine, and purified, concentrated tissue-culture vaccine. The latter was prepared in a human diploid cell strain and inactivated with beta-propiolactone, and consisted of tissue-culture fluid concentrated 200-fold with a final infectivity titre of 10(9.8) plaque-forming units per ml before inactivation. In the first two series of experiments, several vaccines were tested for relative immunogenicity on a pre-exposure basis. In the third series, a successful model was developed in which a single inoculation of the tissue-culture vaccine administered after exposure to rabies virus, with or without accompanying standard doses of antirabies serum, was evaluated as a method of prevention. A single dose of the tissue-culture vaccine protected 7 out of 8 monkeys from death by street virus. Homologous or heterologous antirabies serum alone gave poor results. The results indicate great promise for prophylaxis in man with one dose, or perhaps a few doses, of highly concentrated, purified tissue-culture vaccine.


Correlation of chemical structure of phenothiazines with their coronary dilator and antiarrhythmic activities.


Mutagenic action of edeine in bacteria. II. Induction of streptomycin resistance in Escherichia coli and Bacillus subtilis.


Intraocular pseudotumours in Denmark. A clinical and histopathological analysis and correlation of cases in children from 1942 to 1966.


Quantitative analysis of IGG, IGA and IGM immunoglobulins acute and chronic granulocytic leukemia, polycythemia vera and osteomyelosclerosis syndrome.


Acid-base balance of the blood in patients with hepatic cirrhosis.


Blastic transformation of lymphocytes in some proliferative diseases of the leukocytic system.


Histochemical investigations of some enzymes in the liver in ulcerative disease of the stomach and duodenum.


A rare finding as hernial content in the inguinal hernia in suckling's age.


The renal cortex index and its value in the diagnosis of chronic pyelonephritis.


A method and an apparatus for indirect lighting up by mediastinoscopy.


Finger print pattern types of Bulgarian Mohammedans.


Kinetics of lead metabolism and action of chelating agents.


Intravenous hyperosmolar alimentation. Advantages and complications.


Family planning in health services. Report of a WHO Expert Committee.


Tuberculous lymph nodes and dental infection.


Trimethoprim-sulphamethoxazole.

Trimethoprim-sulphamethoxazole.


Infection and disease in a group of South Indian families. 13. Skin sensitivity to six mycobacterial antigens.


Clinical evaluation of gentamicin in Pseudomonas pyocyaneus infection of the urinary tract.


Isolation of dermatophytes and other keratinophilic fungi from apparently healthy skin coats of domestic animals.


Choice of anti-coagulant in determination of packed cell volume.


Brain abscess due to Listeria monocytogenes in a patient with cirrhosis of the liver.


Unreliability of ultrastructural demonstration of enzymes which depend upon hydrogen peroxide production from action on their substrates.


An isolated dog or monkey heart preparation for studying cardioactive compounds.


Transient kinetic studies of DOPA oxidation by polyphenoloxidase.


Sex differences in emotional behaviour: a reply to Gray and Buffery.


Non-pancreatic proteases of the chymotrypsin family. II. Two proteases from a mouse mast cell tumor.


Some properties of proteinase b in the venom of Agkistrodon halys blomhoffii.


Effect of manganese on the quaternary structure of human liver arginase.


Partial purification and properties of L-phenylalanine ammonia-lyase from Streptomyces verticillatus.


Effect of urea on the two iodine inactivation reactions of Bacillus cereus penicillinase.


Measles immunity in infants.

Measles immunity in infants.


Relationship of lysogeny and megacinogeny in bacillus megaterium.


Effect of pyrazocillin on the induced penicillinase synthesis of Bacillus cereus.


Water limited reaction of Bacillus cereus penicillinase in nonaqueous solvent.


Some properties of the membrane-bound penicillinase of Bacillus cereus 569.


Metabolite analogs as genetic and biochemical probes.


Acute viral infections of the respiratory tract.


Diabetic ketoacidosis.

Diabetic ketoacidosis.


Teratologic evaluation of metaproterenol in the rhesus monkey (Macaca mulatta).


The effects of a heterogeneous environment on the genetics of natural populations.


The metabolism of palmitic acid-1- 14 C in fetal tissue.


From thought to therapy: lessons from a primate laboratory.


Morphological changes of conidiophores and mycelium of some hyphomycetes.


The genus Candida Berkhout. XII. Chemical composition of polysaccharides isolated from cell walls of three strains of Candida guilliermondii (Cast.) Langeron et Guerra and their immunochemical properties.


Active synthesis of IgA in newborn precolostral piglets.


Fine structure of Streptomyces aureofaciens producing tetracycline.


Solid wastes disposal and control. Report of a WHO Expert Committee.


Is our knowledge sufficient about the regulation of protein metabolism?


Measurement of the rehological properties of biological fluids. II.