Research report 1952-1970 of the tissue bank.


Urea content and pH of pilocarpine stimulated rat saliva.


The effect of human supragingival calculus formation of acetohydroxamic acid.


Association of certain variables with the performance of spring vs. fall-born lambs.


Conventional selection indexes for birth and weaning traits in beef calves.


Estimated direct and correlated response to selection for performance traits in closed Hereford lines under different types of environments.


Genetic relationships among growth and carcass traits of beef cattle.


Genotype-environment interaction in sheep. I. Ewe productivity.


Tryptophan requirement of growing chicks as affected by dietary protein level.


Effect of feeding, fasting and infusion of energy substrates on plasma growth hormone levels in cattle.


Effects of age and gonadotropin treatment on superovulation in the calf.


Metabolities of 1-( -methylallylthiocarbamoyl)-2-methylthiocarbamoylhydrazine (methallibure) in swine.


Physiology of pregnancy in tropically adapted cattle. I. Morphological changes in the cow in relation to fetal development.


[Puberty and related phenomena in Angoni (short horn Zebu) bulls].


Seasonal changes in the ejaculate characteristics of Angoni (short horn Zebu) bulls.


Serum biochemical and hematological measurements of heat tolerant (Zebu) and cold tolerant (Scotch Highland) heifers.


Chemical additives in rumen fermentations: in vivo effects of two antiprotozoal compounds on rumen volatile fatty acids.


Effect of dehydrated alfalfa products on the utilization of urea nitrogen in beef cattle.


Effects of various levels of sulfur upon cellulose digestion in purified diets and lignocellulose digestion in corn fodder pellets in vitro.


Limited protein and energy for wintering yearling steers on standing Kentucky bluegrass.


Nutrient digestibility using fecal collection apparatus and indicator method for steers fed ad libitum.


Ovine lactic acidosis: intraruminal and systemic.


Pesticides, environment, and pollution. An interdisciplinary course for the interim.


Isolation of yeast invertase by sephadex gel chromatography. A biochemistry laboratory experiment.


Structure activity relationships of methylenedioxynaphthyl derivatives as synergists of carbaryl in house flies.


Assaying the oral toxicity of organophosphates to house flies without body contact with the insecticides.


Status of carbaryl and DDT resistance in laboratory-reared Egyptian cotton leafworm.


Chemosterilization of the yellow-fever mosquito. 1. Laboratory evaluation of aziridinyl compounds by larval and pupal treatments.


Chemosterilization of the yellow-fever mosquito. 2. Laboratory evaluation of phosphoramides by larval and pupal treatments.


Comparative effectiveness of fast neutrons and gamma rays in producing sterility in house flies.


In vitro microsomal epoxidase activity and susceptibility to carbaryl and carbaryl-piperonyl butoxide combinations in house crickets of different age and sex.


Cholinesterase studies of a malathion-susceptible and a resistant strain of house flies.


An oviposition pheromone associated with the egg rafts of Culex tarsalis.


Insecticide resistance in the house fly: effect of a modifier gene in combination with major genes which confer resistance.


Preliminary investigations on dieldrin accumulation in an insect food chain.


Hempa and metepa as chemosterilants of imagos of the European corn borer.


Competitiveness of gamma-sterilized males of the Mediterranean fruit fly.


Differences in percentages of fatty acids in triglycerides and phospholipids larvae of the bollworm and the tobacco budworm as possible factors in their tolerance to insecticides.


Sterilization of the beet leafhopper: induction of sterility and evaluation of biotic effects with a model sterilant (OM-53139) and  60 Co irradiation.


Toxicity of insecticides to the cowpea curculio in the laboratory.


Toxicities of aldrin and dieldrin to the freshwater ostracod Chlamydotheca arcuata.


Response of German cockroaches to spray constituents.


Fly control, chronic toxicity, and residues from feeding Rabon to laying hens.


Testing of insecticides against the tropical horse tick in the laboratory.


Further evaluation of animal systemic insecticides, 1970.


Susceptibility of immature horn flies to toxins of Bacillus thuringiensis.


Aerial ULV and LV applications of insecticides for control of the stable fly and the horn fly.


Preliminary evaluation of three systemic insecticides in baits for control of fleas of wild rats and rabbits.


Efficacy of insecticides and methods of insecticidal application for control of stable flies in Nebraska.


Tests of aerosols of deet for protection of livestock from biting flies.


A new method of cockroach control on submarines.


The synthetic juvenile hormone for control of Bovicola limbata on Angora goats.


Malathion on milling fractions of three varieties of rough rice: duration of protection and residue degradation.


Response of corn to granular insecticides applied to the row at planting.


Mortality of tephritids attracted to guava foliage treated with either malathion or naled plus protein-hydrolysate bait.


New insecticides for Asiatic rice borer control in paddy rice.


Codling moth catches in sex and light traps after exposure to 0, 25, or 40 krad of gamma irradiation.


Methyl bromide fumigation combined with storage for control of codling moth in apples.


Thixcin E as an extender of poisoned male lures used to control fruit flies in Hawaii.


Fumigation with methyl bromide plus refrigeration to control infestations of fruit flies in agricultural commodities.


Large-scale field tests of soil applications of aldicarb for suppression of populations of boll weevils.


Concrete impregnated with chlordane or dieldrin not tubed over by subterranean termites.


Comparison of commercially produced Bacillus thuringiensis var. thuringiensis with two bioassay techniques based on toxicity units.


Studies on leech repellents.

Studies on leech repellents.


Trunk implantations of dicrotophos for cone-insect control in slash pine seed production stands.


Effects of sublethal doses of naled, carbaryl, malathion, and acetone on the migratory grasshopper.


Field comparisons of insecticidal sprays for control of four tomato insects in south Texas.


Effect of carbon dioxide gas on respiration of the confused flour beetle.


Effects of fractionated dose of gamma irradiation on fecundity, mortality, and longevity of the lesser grain borer.


Toxicity of Zectran to western spruce budworm as a function of application site.


Selection for polygamy and the sterile-insect technique.


Effect of malathion on Indian meal moth egg production and time of deposition under warehouse conditions.


Effect of pollen availability on poisoning of honey bees by carbaryl applied to sweet corn.


Feeding of American and oriental cockroaches on baits imbedded in paraffin.


Effect of in-furrow treatments of three systemic insecticides on grain sorghum emergence.


Effectiveness of carbofuran against strawberry root weevils in peppermint.


DDT-resistant red flour beetles from a Georgia peanut sheller.


Cabbage looper control on collards in Florida.


Sexual competition of gamma-sterilized male cowpea weevils.


Greenbug control on winter wheat with phorate in South Dakota.


Insecticide resistance in Heliothis: tolerance in larvae of H. virescens as compared with H. zea to organophosphate insecticides.


High potassium and low sodium contractures in sheep cardiac muscle. Contractures develop in sheep atrial trabeculae if Tyrode's solution is rapidly replaced by a solution containing elevated potassium, reduced sodium, or both. Two phases of the contracture can be identified on the basis of differences in physiological behavior: a rapid and transient phase that predominates during the first few seconds of the contracture, and a slowly developed phase that is responsible for the steady level of tension reached later in the contracture. The transient phase is particularly prominent if the muscle is stimulated rapidly before the contracture, and reduced or absent if the muscle is not stimulated or if calcium is not present before the contracture. Recovery of the transient phase after a contracture parallels the recovery of twitches. This transient phase appears to reflect the depolarization-induced release of activator (calcium) from an internal store, possibly the same store that is involved in the normal contraction. The slowly developed tension is dependent on the contracture solution used, and is decreased if the calcium concentration is reduced or if the sodium concentration is increased. It does not depend on conditions before the contracture and does not require time to recover. This phase of the contracture may be due to entry of calcium from the extracellular solution.


Equivalent circuit of frog atrial tissue as determined by voltage clamp-unclamp experiments. The equivalent circuit that has been used in the analysis of nerve voltage-clamp data is that of the membrane capacity in parallel with the membrane resistance. Voltage-clamp experiments on frog atrial tissue indicate that this circuit will not suffice for this cardiac tissue. The change in membrane current associated with a step change in membrane potential does not show a rapid spike of capacitive current as would be expected for the simple parallel resistance-capacitance network. Rather, there is a step change in current followed by an exponential decay in current with a time constant of about 1 msec. This relatively slow capacitive charging current suggests that there is a resistance in series with the membrane capacity. A possible equivalent circuit is that of a series resistance external to the parallel resistance-capacitance network of the cell membranes. Another possible circuit assumes that the series resistance is an integral part of the cell membrane. The data presented in this paper demonstrate that the equivalent circuit of a bundle of frog atrial muscle is that of an external resistance in series with the cell membranes.


Two inward currents in frog atrial muscle. The double sucrose-gap voltage-clamp technique was applied to frog atrial tissue to investigate the ionic currents responsible for the action potential in this tissue. Membrane depolarization elicited two distinct components of inward current when the test node was exposed to normal Ringer solution: a fast inward current and a slow inward current. The fast inward current appeared to be carried by sodium ions, since it was rapidly abolished by exposure of the fiber to Na(+)-free solution or tetrodotoxin but persisted on exposure to Ca(++)-free solution. In contrast, in the majority of the preparations the slow inward current appeared to be primarily carried by calcium ions, since it was abolished on exposure of the fiber to Ca(++)-free solution but persisted on exposure to Na(+)-free solution. Action potential data supported the voltage-clamp findings. The normal action potential shows two distinct components in the upstroke phase: an initial rapid phase of depolarization followed by a slower phase of depolarization reaching the peak of the action potential. Abolition of the fast inward current resulted in abolition of the initial rapid phase of depolarization. Abolition of the slow inward current resulted in abolition of the slow phase of depolarization. These data support the hypothesis that two distinct and different ionic mechanisms contribute to the upstroke phase of the action potential in frog atrial tissue.


Intensity characteristics of the noctuid acoustic receptor. Spiking activity of the more sensitive acoustic receptor is described as a function of stimulus intensity. The form of the intensity characteristic depends strongly on stimulus duration. For very brief stimuli, the integral of stimulus power over stimulus duration determines the effectiveness. No response saturation is observed. With longer stimuli (50 msec), a steady firing rate is elicited. The response extends from the spontaneous rate of 20-40 spikes/sec to a saturated firing rate of nearly 700 spikes/sec. The characteristic is monotonic over more than 50 db in stimulus intensity. With very long stimuli (10 sec), the characteristics are nonmonotonic. Firing rates late in the stimulus decrease in response to an increase in stimulus intensity. The non-monotonic characteristics are attributed to intensity-related changes in response adaptation.


Two light-induced processes in the photoreceptor cells of Limulus ventral eye. The dark-adapted current-voltage (I-V) curve of a ventral photoreceptor cell of Limulus, measured by a voltage-clamp technique, has a high slope-resistance region more negative than resting voltage, a lower slope-resistance region between resting voltage and zero, and a negative slope-resistance region more positive than 0 v. With illumination, we find no unique voltage at which there is no light-induced current. At the termination of illumination, the I-V curve changes quickly, then recovers very slowly to a dark-adapted configuration. The voltage-clamp currents during and after illumination can be interpreted to arise from two separate processes. One process (fast) changes quickly with change in illumination, has a reversal potential at +20 mv, and has an I-V curve with positive slope resistance at all voltages. These properties are consistent with a light-induced change in membrane conductance to sodium ions. The other process (slow) changes slowly with changes in illumination, generates light-activated current at +20 mv, and has an I-V curve with a large region of negative slope resistance. The mechanism of this process cannot as yet be identified.


Fine structure of extra-nodal transitional cardiocytes in rat left atrium.


Miniature end-plate potentials in neuromuscular disease: an electrophysiological investigation of motor-point muscle biopsies. A technique is described for the electrophysiological investigation of motor-point muscle biopsies and the data from 13 biopsies are reported. It was not possible to demonstrate any influence of disease upon the resting potentials of individual biopsies, but resting potentials were in general lower than those reported for limb muscle in vivo. Miniature end-plate potentials (MEPPs) in clinically normal limb muscle were smaller and more frequent than those previously described in isolated intercostal muscle. In two biopsies from myasthenic patients very small amplitude MEPPs were recorded and, in one of these, MEPPs were also of very low frequency, possibly associated with the severity of the disease. The frequency and amplitude of MEPPs in muscular dystrophy and neurogenic disease have been reported and the possible significance of these findings is discussed.


Mechanical properties of dystrophic mouse muscle. A physiological method of estimating the number of motor units in normal and dystrophic muscles has revealed a large reduction in the number of motor units in dystrophic muscles. Anatomical confirmation of the results has been obtained. Dystrophic muscles also exhibit a `myasthenic-like' response to high frequency stimulation. It is suggested that the nerve fibre is primarily affected in murine dystrophy.


Myasthenia gravis occurring in twins.

Myasthenia gravis occurring in twins. Myasthenia gravis in one member each of two sets of twins is described. A 17 year old girl developed generalized myasthenia gravis at the age of 14 years, while her monozygotic twin sister has remained in good health during a three year period of observation. Another patient was a 19 year old woman with the onset of generalized myasthenia gravis at the age of 11 years, and her dizygotic twin sister has been in good health.Myasthenia gravis has been described in 13 sets of monozygotic twins, seven sets of dizygotic twins, and one set of twins with undetermined zygosity. Both members of twins were affected in five sets of monozygotic twins and one set of twins with undetermined zygosity, and only one twin was affected in the remaining sets of twins. Occurrence of myasthenia gravis in both members of monozygotic twins and in none of dizygotic twins, and frequent familial occurrence of the disease suggest the role of a genetic factor in the pathogenesis of this disease.


Prognosis of pituitary adenomas with arteriographic abnormal vascularization. A case report and five additional cases from the literature of angiographically demonstrated abnormal vascularization of chromophobe adenomas are presented. The appearance is that of a fine network of vessels appearing in the arterial phase and a homogeneous blush beginning in the capillary phase and lasting throughout the venous phase. The network is derived from dilated branches of the extradural internal carotid artery and is seen in the arterial phase. The stain, appearing in the venous phase, is due to filling of tiny sinusoidal channels and thin-walled vessels throughout the stroma. All the patients had large, actively growing tumours which compressed and infiltrated surrounding structures. Complete tumour removal was not possible in the patients operated upon. The combined morbidity-mortality rate was 83% and was due to the large tumour size, adherence to vital centres, extreme vascularity during surgical removal, and propensity to bleed spontaneously. The appearance of abnormal vascularity in a pituitary adenoma suggests a poor prognosis.


Ependymal cyst of the spinal cord: case report. A subarachnoid ependymal cyst of the spinal cord is rarely reported. A 44 year old man with a cyst compressing the lower spinal cord and conus medullaris is described. Excellent functional recovery followed excision of the lesion. The cells lining the cyst were histologically indistinguishable from normal ependymal cells, but, unlike the normal ependymal cells which are related to subependymal glial tissue, the cells lining the cyst abutted directly on the connective tissue forming the cyst wall. This is in contrast with ependymal lined cysts occurring within the conus medullaris, and intradural teratomatous cysts which consistently contain intracytoplasmic mucinous material. It is postulated that an ependymal cyst could result from isolation of ependymal cells from either the roof or floor plates during embryogenesis of the neural tube.


Buphthalmia in the rabbit: glucose metabolism.


Altered thermal sensitivity in injured and demyelinated nerve. A possible model of temperature effects in multiple sclerosis. Electrophysiological studies were performed on frog and guinea-pig peripheral nerves to determine the effect of temperature on conduction at the site of pressure and demyelinating lesions. An increased susceptibility to thermally-induced conduction blockade has been demonstrated. In pressure-injured frog and guinea-pig nerves, conduction blocks occur at temperatures approximately 6°C lower than in normal nerves. A similar phenomenon occurs in guinea-pig demyelinated nerve (experimental allergic neuritis) and in some cases at temperatures around 15°C lower than in controls. It is suggested that these effects are the result of a critical lowering by temperature of an already markedly depressed conduction safety factor. In support of this, it has been shown that calcium ion depletion, which would be expected to increase the conduction safety factor by lowering the threshold for excitation, counteracts the increased thermal sensitivity of frog pressure-injured nerve. These findings are discussed in relation to well-known temperature effects in multiple sclerosis. They add support to an earlier proposed hypothesis that the changes in signs and symptoms with a change of body temperature in multiple sclerosis may be caused by an effect of temperature on axonal conduction.


Orthostatic hypotension and the Holmes-Adie syndrome. A study of two patients with afferent baroreceptor block. Two patients who presented with symptoms due to orthostatic hypotension were found on examination to have the Holmes-Adie syndrome. Physiological investigation suggested that they both had an afferent block from baroreceptors in contrast to the efferent autonomic block found in most other cases of idiopathic orthostatic hypotension, including the cases of multisystem disease, now often called the Shy-Drager syndrome.


Common carotid ligation for the treatment of ruptured posterior communicating aneurysms. Sixty-four consecutive cases of ruptured posterior communicating aneurysms were investigated. Fifty-one cases were treated by abrupt ligation of the common carotid artery with no operative mortality and a small temporary operative morbidity.


Effect of folic acid by mouth on cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentration. Administration of 30 mg folic acid by mouth caused a significant fall in cerebrospinal fluid homovanillic acid concentration in 11 subjects. There was no significant change of 5-hydroxyindoleacetic acid concentration. The fall was less marked in five patients on anticonvulsant medication and failed to reach statistical significance. Neither homovanillic acid nor 5-hydroxyindoleacetic acid concentrations changed significantly when 15 mg folic acid was given in divided dosage for one, two, and four weeks. The effect appeared to be related to the height of serum-folate levels reached and to be independent of cerebrospinal fluid-folate levels, which did not change significantly. Possible mechanisms and their potential therapeutic application are discussed.


Karyotype of the American red fox (Vulpes fulva).


Response of cereborspinal fluid pressure to hyperbaric oxygenation. The response of cerebrospinal fluid pressure (CSFP) to hyperbaric oxygenation (OHP) was investigated in 13 patients with acute cerebral damage and in dogs with or without experimentally produced cerebral damage. To elucidate the mechanism of the CSFP response, continuous measurements of carotid blood flow, arterial blood pressure, central venous pressure, and superior sagittal sinus pressure and CSFP were made before, during and after OHP. There was considerable variation in the response of CSFP to OHP in the patients, but three main patterns emerged; type I (nine cases), CSFP decreased at the beginning and rose again at the end of OHP, type II (two cases), CSFP fell with OHP and remained significantly lower than pretreatment level after it, and type III (two cases), CSFP showed little change with OHP. An animal without cerebral damage commonly showed a type I response of CSFP to OHP; the changes of CSFP at the beginning and end of OHP are mainly due to the changes of the cerebral blood flow. There may be two different actions of OHP on cerebral oedema, one decreasing cerebral oedema and another (mainly affecting the normal brain) producing cerebral oedema. Information obtained from the response of CSFP to OHP may be useful in judging the severity and pathophysiological state of cerebral damage.


Non-uniform response of regional cerebral blood flow to stimulation of cervical sympathetic nerve. Regional cerebral blood flow (CBF) was measured by an autoradiographic method in nine adult cats, using antipyrine-(14)C as a diffusible indicator. In seven of the cats, CBF measurements were made during stimulation of a cervical sympathetic trunk. Stimulation caused minor regional decreases of CBF in at least five of these seven cats. The decreases were non-uniform and occurred almost exclusively in cortical structures. Although constriction of cervical arteries probably accounts for some of the effects of sympathetic stimulation, the present study indicates that there is also an effect on cerebral regulatory arterioles. However, there is no convincing evidence that function of the autonomic nervous system is necessary for the normal regulation of the cerebral circulation.


Human flexor reflexes.

Human flexor reflexes. One type of flexor reflex, that recorded from the tibialis anterior muscle in response to electrical stimulation of the sole of the foot, was studied in normal subjects and patients with several neurological disorders. Normally this reflex consists of two components, the second of which is related to the actual withdrawal. The first component, normally of lower threshold, is difficult to evoke in patients with chronic spinal cord or discrete cerebral lesions, whereas it has an unusually low threshold and is very clearly seen in those with Parkinson's disease. In patients with spinal cord disease, the exaggerated flexor reflexes are seen at long latencies after relatively small stimuli. During the early phase of recovery from spinal transection, both components may be seen and are, therefore, spinal in origin. Studies of patients with the sensory neuropathy of Friedreich's ataxia suggest that the afferent fibres responsible for these flexor reflexes are the small myelinated fibres. Recovery curves demonstrate very long-lasting changes in flexor reflex excitability in normal subjects and patients with `spasticity' from spinal lesions. This differs in patients with `spasticity' from lesions rostral to the brain-stem. Examples in man of such physiological phenomena as reciprocal inhibition, local sign, habituation, temporal and spatial summation are discussed.


Scoliosis: a rare manifestation of intrinsic tumours of the spinal cord in children. Three cases are described of apparent idiopathic scoliosis in childhood which were shown subsequently to be due to intramedullary spinal cord tumour. The possibility of this underlying lesion should be considered in any child who develops scoliosis without an obvious cause.


Effect of selenium, synthetic antioxidants, and vitamin E on the incidence of exudative diathesis in the chick.


Biological half-life of phenobarbital in human babies.


Temporal arteritis in Rochester, Minnesota, 1951 to 1967.


The Aboriginal infant mortality rate.

The Aboriginal infant mortality rate.


[Present-day antitubercular therapy].

[Present-day antitubercular therapy].


[Cases of psychomotor epilepsy appearing in the first 3 years of life].


Synthetic pelvic floor sling to decrease small bowel complications after total exenteration.


A joint x-ray radiation survey in Puerto Rico, 1968.


Gross radioactivity in surface waters of the United States, February 1971.


Radioactivity in California waters, January-December 1969.


Radioactivity in airborne particulates and precipitation.


Radiostrontium in tap water, July-December 1970.


Tests of vitamin B 12  absorption.

Tests of vitamin B 12  absorption.


The repair of incisional and inguinal hernias.


Coccidioidomycosis.

Coccidioidomycosis.


The ambulance--friend or foe.

The ambulance--friend or foe.


Practical applications for the computer in the physician's office today.


Prolonged partial bypass for correction of recurrent coarctation of the aorta in a patient with unilateral renal agenesis.


A report of an anomalous bifurcation of the right axillary artery in man.


Subclavian steal syndrome.

Subclavian steal syndrome.


The thoracic outlet compression syndrome--a reappraisal.


Paradoxical effect on peripheral blood flow after sympathetic blockades in patients with gangrene due to arteriosclerosis obliterans.


Woven teflon aortic grafts. An unsatisfactory prosthesis.


Pre-operative phlebography in peripheral vascular reconstruction.


Thick filaments in a freeze-etched vertebrate smooth muscle.


Electron microscopy and electron microscopical measurements of collagen mineralization in hard tissues.


Atherosclerosis in Africa--studies of coronary arteries, blood lipids and coagulation factors in Uganda.


Atherosclerosis in Rhodesia.

Atherosclerosis in Rhodesia.


Atherosclerosis and lipid metabolism in the Masai of East Africa.


Chemical and structural aspect of atherosclerosis.


Effect of mild hypothermia and surgery on adrenocortical function in man.


Cytoplasmic inclusion bodies in pulmonary tumors: an electron microscopic study.


Encephalopathy and fatty degeneration of the viscera: a clinicopathologic analysis of 40 cases.


Corynebacterium vaginale vaginitis in pregnant women.


Coarctation of the aorta, rheumatic valvulitis, and infectious endocarditis: report of a case.


Patterns of enzyme activity following myocardial infarction and ischemia.


Determination of mammalian serum  -amylase levels with a radioactive-substrate assay.


Evaluation of a chemistry kit system: comparison of the performances of trained and untrained persons.


A semiquantitative method for the detection of cold agglutinins at room temperature.


Hemoglobin function in stored blood. VI. The effect of phosphate on erythrocyte ATP and 2,3-DPG.


The use of closed circuit television in chromosome analysis.


Collection of large amounts of platelets from a single donor for testing in vitro.


Semiautomated fluorometric assay for submicrogram quantities of morphine and quinine in human biological material.


A program of statistical designs for optimizing specific transfer ribonucleic acid assay conditions.


Fluorometric methods for analysis of acid and alkaline phosphatase.


Fluorometric determination of submicrogram quantities of antimony.


A new approach to the microdetermination of fluoride. Adsorption-diffusion technique.


Rapid and simplified method for liquid scintillation counting of radioactive proteins utilizing aquasol.


New spectrophotometric method for determination of formaldehyde.


Thin layer chromatography of hexosamines on copper impregnated sheets.


Gas-liquid chromatography of the optical isomers of threonine and allothreonine.


Effect of estradiol on 7,12-dimethylbenz(a)anthracene-induced adrenocortical necrosis. A histochemical study.


Effect of solvent upon the fluorescence decay of indole.


Hb Ft. Worth: a27Glu changed to Gly(B8). A variant present in unusually low concentration.


The hemichromogen form of the isolated subunits of hemoglobin.


DEAE-cellulose chromatography of human transferrin: the effect of increasing iron saturation and copper(II) binding.


On the chemical iodination of tyrosine with protein sulfenyl iodide and sulfenyl periodide derivatives. The behaviour of the thiol protein-iodine systems.


Purification and properties of cytochrome c 3  of Desulfovibrio vulgaris, Miyazaki.


Physicochemical properties of some acyl derivatives of  -casein.


Isolation and properties of  -lactalbumin from various sources.


Human liver arylamidase: molecular weight and subunit structure.


The reaction of  -,  -, and acetylated- -chymotrypsin with radioactive formaldehyde.


Fractionation of histones from chicken erythrocyte and sea urchin sperm by CM-cellulose chromatography with ethanolic formic acid.


Behaviour of mouse H-2 specificities on polyacrylamide gel electrophoresis and polyacrylamide gel electrofocussing.


Studies on adrenaline-induced leucocytosis in normal man. I. The role of the spleen and of the thoracic duct.


Folate analogues in normal mixed diets.

Folate analogues in normal mixed diets.


Persistent mixed-field polyagglutination.


The chromosomes of bone-marrow cells of haematologically normal men and women.


The oxygen affinity of haemoglobin in chronic renal failure.


Haematological effects in mice of partially purified colony stimulating factor (CSF) prepared from human urine.


Metabolic fate of d-cis-3-acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride (CRD-401).


Studies on antitumor substances. XI. Reactions of Bunte salts with nucleophiles.


Synthesis and characterization of nuclear RNA induced by radix ginseng extract in rat liver.


C-2 hydroxylation of 2-deuterioestrogen in the rat. Lack of "NIH" shift".


Stimulating effect of Panax ginseng extract on RNA polymerase activity in rat liver nuclei.


Inhibition of guanine deaminase with derivatives of imidazole.


Substrate induced difference spectrum of microsomal P-450 in human liver.


Tremorgenic toxins from Aspergillus fumigatus Fres.


The relationship of some intermediary metabolites to the production of volatile fatty acids by adult Fasciola hepatica.


Partial purification and properties of glucose-6-phosphate dehydrogenase from Macracanthorhynchus hirudinaceus (Acanthocephala).


Polymorphism in fowl serum albumin. I. Characterization of two genetic variants of fowl serum albumin and definition of peptide differences.


The hemoglobins of Myxine glutinosa L. I. Preparation and crystallization.


Inhibition by actinomycin D of the initiation of chitin biosynthesis in the crayfish.


Energetics of ion transport in the gills of the crayfish Astacus leptodactylus esch.


Serum lipoproteins of killer whales.

Serum lipoproteins of killer whales.


A study of the effects of gonadal hormone administration on some enzymes of amino acid metabolism in the oviduct of the immature domestic fowl.


Glycogen phosphorylase levels in spontaneously beating turtle hearts.


Monitoring the critically ill patient with the aid of a digital computer.


Some observations on the economics of computer systems for monitoring electrocardiographic rhythms.


On-line processing of the video-image for left ventricular volume determination.


A videometric technique for automated processing of pressure-volume-diagrams.


A PVC detection program.

A PVC detection program.


P-wave detection by digital computer.

P-wave detection by digital computer.


Detection of premature ventricular contractions with a clinical system for monitoring electrocardiographic rhythms.


Computer improvement of anger camera images.


A note on filtering electrocardiograms.

A note on filtering electrocardiograms.


An efficient method for multiexponential fitting with a computer.


Bayes' theorem applied to chromosome classification.


Intensive care units.

Intensive care units.


[Work-seat catalog as a new organizational form of central clinical laboratory].


Morpho-topochemical architecture of the nervous system after transplantation of Crocker sarcoma. I. Golgi apparatus and glycogen in sensory and motor neurons after transplantation of sarcoma 180.


Dermal scutes in certain genera and species of the family Scincidae.


Morpho-topochemical architecture of the nervous system after transplantation of Crocker sarcoma. II. Cytochemistry of nucleic acids and different proteins in sensory and motor neurons after transplantation of sarcoma 180.


Oxidase activity of leucocytes in different animals and man.


Analgesic effect of some monoamine oxidase inhibitors.


Pharmacological and haemostatic investigations on Sphaeranthus indicus Linn.


Conditioned learning in pregnancy.

Conditioned learning in pregnancy.


Studies on the sensation of taste.

Studies on the sensation of taste.


Age-dependant variation in ribonucleic acid content of the rat diaphragm.


Vagal inhibition of heart in hypoxic dogs.


Intramolecular interactions in aromatic amino acids and model compounds.


Stretched-film spectra and transition moments of nucleic acid bases.


Stereochemistry of nucleic acids and their constituents. 18. Conformational analysis of alpha nucleosides by x-ray crystallography.


Proton magnetic resonance study on adenine dideoxynucleoside monophosphate with emphasis on the furanose conformation.


Syntheses and properties of adenine and thymine nucleoside alkyl phosphotriesters, the neutral analogs of dinucleoside monophosphates.


Total synthesis of dl-Y base from yeast phenylalanine transfer ribonucleic acid and determination of its absolute configuration.


Denatured hemoproteins as catalysts in lipid oxidation.


Fat oxidation at low oxygen pressure. 3. Kinetic studies on linoleic acid oxidation in emulsions in the presence of added metal salts.


Marketing considerations for improved protein food products.


The functional requirements of proteins for foods.


Castor meal antigen deactivation--pilot plant steam process.


The docosahexaenoic acid of marine organisms.


Measurements of low levels of phosphate in detergents.


Hypothalamus and its effects on the viscera.


Selective left atrial cineangiography in the recognition of atrial thrombus. (A preliminary report on 18 cases).


Congenital absence of the left pericardium. (A case report).


Chronic pyelonephritis. (A clinicopathological study).


Lactase activity in irritable colon syndrome.


Metronidazole in intestinal amoebiasis and its complications. (Further observations).


Metronidazole in amoebic liver abscess.

Metronidazole in amoebic liver abscess.


Respiratory function and right heart haemodynamics in chronic cor pulmonale.


Infra-pulmonary pleural effusion.

Infra-pulmonary pleural effusion.


Primary alveolar hypoventilation.

Primary alveolar hypoventilation.


Characterization of a thermolabile sulfite reductase from Salmonella pullorum. The biochemical basis for sulfite accumulation by sulfate-using revertants of Salmonella pullorum was determined. All of the sulfate-using mutants isolated from wild-type S. pullorum accumulated sulfite when grown at 37 but not at 25 C. The specific activity of reduced nicotinamide adenine dinucleotide (NADPH)-dependent sulfite reductase (H (2)S-NADP oxidoreductase, EC 1.8.1.2) and of reduced methyl viologen (MVH)-dependent sulfite reductase (H (2)S-MV oxidoreductase), in extracts prepared from cells incubated at 37 C, declined as the incubation period lengthened. However, the specific activity of both reductases from cells incubated at 25 C did not decline. Thermolability of cell-free NADPH-dependent sulfite reductase from cells of S. pullorum incubated at 37 C was greater than the lability of this enzyme either from cells of S. typhimurium incubated at 37 C or from cells of S. pullorum incubated at 25 C. Cells cultured at 37 C continued to accumulate sulfite when the incubation temperature was shifted to 25 C; cells cultured at 25 C and shifted to 37 C accumulated no sulfite, whereas these cells shifted to 41 C accumulated sulfite. It was concluded that the configuration of the sulfite reductase of S. pullorum strain 6-18 is a function of the incubation temperature at which synthesis occurs.


Purification and properties of an polygalacturonic acid trans-eliminase produced by Bacillus pumilus. A strain of Bacillus pumilus produced an extracellular pectic enzyme with polygalacturonic acid as the substrate. This enzyme, with optimal activity at pH 8.0 to 8.5, produced reaction products that strongly absorbed light at 232 nm, indicating the presence of a pectic acid trans-eliminase (PATE). Neither pectin esterase nor polygalacturonase was detected in the cell-free culture fluid. Chromatographic examination of the end products revealed the presence of large quantities of unsaturated oligouronides unlike those found with B. polymyxa. It was found that the PATE was produced extracellularly during the negative logarithmic death phase of the organism. The filtrate from sonically treated cells did not show any activity for PATE or hydrolases for lower oligogalacturonides at any time during the growth cycle. The enzyme was inducible. Pectin, National Formulary (NF) was the best inducer, followed by polygalacturonic acid and galacturonic acid. Enzyme activity was markedly stimulated by calcium and other divalent ions. Copper and cobalt ions were inhibitory. The partially purified enzyme showed no significant activity on pectin containing a high methoxyl content (96% esterified). However, pectin NF with a lower methoxyl content (68% esterified) was attacked to a degree by the partially purified and crude enzyme preparations. The initial rate of PATE activity increased up to 60 C, about 16-fold higher than that observed at room temperature. The activation energy was calculated as 12,183 cal/mole. A protective action of calcium chloride against heat inactivation of the PATE was observed. Degradation of polygalacturonic acid by this enzyme produced several unsaturated oligouronides soon after its addition to the substrate. The major endproduct was thought to be different from that of other known PATE enzymes. Paper chromatographic studies and viscosity measurements disclosed the random cleaving nature of the enzyme an endo-PATE.


Genetic order of the galactose structural genes in Saccharomyces cerevisiae. The galactose structural genes of Saccharomyces cerevisiae were ordered by determining the genotypes of mitotic and meiotic recombinants from crosses heterozygous for the three genes. The most probable order is centromere-gal7-gal10-gal1. Nonreciprocal recombination was more frequent than reciprocal exchange, and both mitotic and meiotic co-conversions involving mutant sites in all three genes were observed.


Metabolism of phosphatidylglycerol, lysylphosphatidylglycerol, and cardiolipin of Staphylococcus aureus. Staphylococcus aureus accumulated cardiolipin (CL) and lost phosphatidylglycerol (PG) during the stationary phase of growth. The minor lipids, phosphatidylethanolamine and phosphatidylglucose, also accumulated, whereas the lysylphosphatidylglycerol (LPG) content of the membrane remained constant as stationary phase continued. During exponential growth, the proportions and total content of phospholipids per cell remained constant. The metabolism of the phospholipids was examined under these conditions. In pulse-chase experiments, the phospholipids lost (14)C from the glycerols slower than (32)P. When the phospholipids were labeled with (14)C glycerol, the unacylated glycerols of PG and LPG lost (14)C, whereas the diacylated glycerols either accumulated or did not lose (14)C. In all experiments, the PG showed a more rapid metabolism than the LPG. When staphylococcal CL was hydrolyzed by Haemophilus parainfluenzae CL-specific phospholipase D into phosphatidic acid (PA) and PG, the incorporation of (32)P into both of the phosphates of CL was found to be parallel at both the PG and PA ends of the molecule. However, the specific activity of the (32)P at the PA end was twice that at the PG end of the molecule. The PG end of the CL apparently came from a portion of the cellular PG pool with about 20% the specific activity of the total cellular PG. The turnover of two of the glycerols of the PG portion of CL was like that of the cellular PG. The diacylated glycerol of the PG and of CL and of the membrane PG showed neither turnover nor incorporation of (14)C. Half of the radioactivity was lost from the middle glycerol of CL and the free glycerol of the cellular PG in one bacterial doubling. The diacylated glycerol from the other end of the CL molecule (the PA end) lost radioactivity almost as rapidly as the middle glycerol for 10 min. After the initial rapid loss, the turnover slowed to a rate 10 times slower than the middle glycerol, indicating that the (14)C was actually accumulating at this end of the molecule. The phosphates and glycerols involved in the hydrolysis and resynthesis of the CL molecule during exponential growth in S. aureus apparently come from different pools of PG.


Regulation and self-inhibition of Microsporum gypseum Macroconidia germination. Germination of Microsporum gypseum macroconidia was accompanied by the release of alkaline protease, calcium ions, and inorganic phosphate into the germination fluid. The rate of germination was greatest during the first 2 hr, decreasing thereafter. This decrease in rate was accompanied by a decrease in protease activity, which was caused by an interaction of the enzyme with the inorganic phosphate released from the spores and accumulated in the germination medium after 2 hr. Germination of high spore densities was regulated by the ratio of released phosphate to protease protein, resulting in a constant percentage of germination at both high and low spore densities. A germination-defective mutant strain failed to germinate normally and released excessively high concentrations of phosphate into the germination medium during the initial 2 hr of incubation. Addition of calcium ions to germination mutant macroconidia stabilized spore morphology, prevented protease inactivation, and allowed normal germ-tube outgrowth. The germination of macroconidia appears to be regulated by the release of phosphate ions, which then inhibit the alkaline protease.


Effect of growth temperature on the lipid composition of Thermus aquaticus. The complex lipids of Thermus aquaticus include phospholipids, glucolipids, carotenoids, and vitamin K(2) isoprenologues. The phospholipids account for 30% of the total lipids and have been identified as phosphatidylethanolamine (4%), phosphatidylglycerol (3%), phosphatidylinositol (10%), cardiolipin (3%), and phosphatidic acid (1%). The major phospholipid contained three fatty acids, a long-chain unsaturated amine, and one glycerol per phosphate and accounted for 80% of the lipid phosphate. The carotenoids accounted for 60% of the membrane lipid. The majority of the carotenoids were very polar. Mono- and diglucosyldiglyceride and the 35-, 40-, and 45-carbon vitamin K(2) isoprenologues were also identified. All these lipids were localized in the membrane of T. aquaticus. When the growth temperature was increased from 50 to 75 C and measured at 5 C intervals, there was a progressive increase in the total lipid content. The phospholipids increased 2-fold, the carotenoids increased 1.8-fold, and the glucolipids increased 4-fold between cells grown at 50 C and 75 C. The vitamin K(2) level did not change. The proportions of the individual lipids within each lipid class remained constant as the temperature of growth was raised. Metabolic studies indicated turnover of the diacyl phospholipids during pulse-chase experiments at rates comparable with mesophilic bacteria. The major phospholipid and the carotenoids did not turn over.


Growth of Aerobacter aerogenes on D-arabinose: origin of the enzyme activities. Mutants of Aerobacter aerogenes can be selected which are capable of utilizing d-arabinose as a sole source of carbon and energy for growth. Mutants can also be selected which are capable of using l-xylose. The mutational event permitting the utilization of d-arabinose results in the constitutive synthesis of certain enzymes of the l-fucose catabolic pathway. l-Fucose isomerase catalyzes the first reaction in the degradation of d-arabinose: the isomerization of d-arabinose to d-ribulose. No other type of mutation appears to be required to initiate growth on d-arabinose, and wild-type cells induced for the enzymes of the l-fucose catabolic pathway are capable of growth on d-arabinose. The first reaction in the catabolism of l-xylose, the isomerization of l-xylose to l-xylulose, also appears to be catalyzed by constitutively synthesized l-fucose isomerase.


Utilization of glucose and the effect of organic compounds on the chemolithotroph Thiobacillus ferrooxidans. The utilization of glucose by the chemolithotroph Thiobacillus ferrooxidans results in a repression of the ability to oxidize iron, the substrate for autotrophic growth. An assay with resting cells was used to measure iron oxidation rates. Concomitant with the decreased iron oxidation rates, the enzyme responsible for carbon dioxide fixation, ribulose diphosphate (RuDP) carboxylase, was also repressed. Maximum iron oxidation rates precede peak RuDP carboxylase levels, consistent with the role of these processes in autotrophic metabolism in nonrepressed cells. The degree of iron oxidation repression depends on the organic substrate supplied, as does the level of RuDP carboxylase. The uptake of glucose parallels an increase in synthesis of glucose-6-phosphate dehydrogenase and the accumulation in cells of poly-beta-hydroxybutyrate. The organism is also capable of growing on glucose and other organic supplements in the absence of its inorganic energy source; growth rates depend on the organic substrate supplied.


Metabolism of D-arabinose by Aerobacter aerogenes: purification of the isomerase. In Aerobacter aerogenes, the mutational event permitting the utilization of d-arabinose as a source of carbon and energy is a regulatory mutation resulting in the constitutive synthesis of certain enzymes of the l-fucose catabolic pathway. l-Fucose isomerase catalyzes the isomerization of d-arabinose to d-ribulose. This enzyme was purified to homogeneity as indicated by a single band in disc-gel electrophoretic columns and single peaks with column chromatography and ultracentrifugation from the wild-type PRL-R3 strain, induced with l-fucose and two constitutive mutants, 502 and 510. The ratios of the activities of this isomerase on d-arabinose and l-fucose remained constant throughout all purifications. The apparent K(m) of the isomerase from the wild-type strain induced with l-fucose and from the constitutive mutant strains was 5.0 x 10(-2)m for l-fucose and 1.5 x 10(-1)m for d-arabinose. A strain 531 possessing an apparent alteration in the isomerase was isolated from the strain 502. This altered isomerase exhibited a lowered K(m) for d-arabinose.


Neutral lipids in the study of relationships of members of the family  micrococcaceae. The organisms studied were those of the family Micrococcaceae which cannot participate in genetic exchange with Micrococcus luteus and those whose biochemical and physiological characteristics appear to bridge the genera Staphylococcus and Micrococcus. The hydrocarbon compositions of M. luteus ATCC 4698 and Micrococcus sp. ATCC 398 were shown to be similar to those previously reported for many M. luteus strains, consisting of isomers of branched monoolefins in the range C25 to C31. However, Micrococcus sp. ATCC 398 differed somewhat by having almost all C29 isomers (approximately 88% of the hydrocarbon composition). Micrococcus spp. ATCC 401 and ATCC 146 and M. roseus strains ATCC 412, ATCC 416, and ATCC 516 contained the same type of hydrocarbon patterns, but the predominant hydrocarbons were within a lower distribution range (C23 to C27), similar to Micrococcus sp. ATCC 533 previously reported. The chromatographic profile and carbon range of the hydrocarbons of an atypical strain designated M. candicans ATCC 8456 differed significantly from the hydrocarbon pattern presented above. The hydrocarbons were identified as branched and normal olefins in the range C16 to C22. Studies of several different strains of staphylococci revealed that these organisms do not contain readily detectable amounts of aliphatic hydrocarbons. The members of the family Micrococcaceae have been divided into two major groups based on the presence or absence of hydrocarbons. With the exception of M. candicans ATCC 8456, this division corresponded to the separation of these organisms according to their deoxyribonucleic acid compositions.


Transfer ribonucleic acid methylases during the germination of Neurospora crassa. Transfer ribonucleic acid (tRNA) methylases were studied during the germination of spores in Neurospora crassa. The total methylase capacity and base specific tRNA methylase activities were determined in extracts from cells harvested at various stages of germination. Germinated conidia have a 65% higher methylase capacity than ungerminated conidia. Three predominant methylase activities were found in the extracts, and the relative amount of each activity was different at the various stages. Enzymes from vegetative cells catalyzed significant hypermethylation of tRNA from conidia, whereas conidial enzymes were much less active on tRNA from vegetative cells. The results indicate differences in the tRNA methylase content and tRNA species of conidia and vegetative cells.


Biphasic growth of Acetobacter suboxydans on a glycerol-limiting medium. Dihydroxyacetone was quantitatively produced from glycerol during the primary exponential growth phase and depleted during the secondary exponential phase. Although no growth was detected on the basal medium, growth occurred upon addition of dihydroxyacetone.


Analysis of a model for multiseptation in bacteria. The predictions of a model for multiseptation in bacteria recently proposed by Paulton are derived mathematically. It is shown that independent of the growth rate, the time between septum formation and cell division is given by t(s) = S . t, where S is the average number of successive division sites and t is the generation time. This result is in good agreement with the experimental data.


Complementation and genetic recombination in Candida lipolytica. Nutritional requirements were introduced into wild-type, heterothallic strains of Candida lipolytica by exposing the cells to X rays. Complementing hybrids were recovered from mixtures of the auxotrophic strains, and genetic recombination was observed in individually isolated ascospores from the hybrid strains.


On the interaction between specimen and testing machine in mechanical testing procedures.


The determination of a creep modulus for articular cartilage from indentation tests of the human femoral head.


Flexure of layered cranial bone.

Flexure of layered cranial bone.


Nystatin-resistant mutants of yeast: alterations in sterol content. Mutants of the genes nys1 and nys3 differ from sensitive strains (nys(+)) in their sterol content. Ultraviolet absorption spectra of the nonsaponifiable material extracted from cells of nys(+) demonstrated the presence of ergosterol and 24(28)-dehydroergosterol. In nys1 mutants, the spectrum suggests the presence of a new sterol. The absorption spectrum of extracts from nys3 mutants indicates absence of both ergosterol and 24(28)-dehydroergosterol and presence of another new sterol. Conversion of nys(+) and nys3 to petite results in loss of 24(28)-dehydroergosterol in the former and the new sterol in the latter, whereas the new sterol in nys1 is only reduced. The sterols in ethanol-grown cells of all genotypes are essentially the same as is found for growth on glucose. With the exception of nys3 grown on ethanol, the mutants do not appear to be at a disadvantage compared to wild type.


Measurements of mass diffusivity of gases in plasma and reaction velocity constant in bloods.


Experimental studies of the dissolution of gas bubbles in whole blood and plasma. I. Stationary bubbles.


Experimental studies of the dissolution of gas bubbles in whole blood and plasma. II. Moving bubbles or liquids.


Peristaltic carrying and mixing of chyme in the small intestine (an analysis of a mathematical model of peristalsis of the small intestine).


Comparison of different models of the heart muscle.


Hormonal iodine in the dog.

Hormonal iodine in the dog.


Determination of plasma oestriol in normal pregnancy and labour using gas-liquid chromatography.


Acute effects of synthetic porcine calcitonins on the renal excretion of magnesium, inorganic phosphate, sodium and potassium.


Effects of stilboestrol on growth hormone secretion and pituitary cell proliferation in the male rat.


Synthesis of androgens in vitro by testes of rats acclimatized to a hot environment.


Inhibition of ovulation by an anti-pig-luteinizing hormone serum.


The effect of cortisol on the tolerance to glucose of thyroidectomized calves.


Rates of incorporation of ( 3 H)leucine into protein of the pars intermedia of the pituitary in the amphibian Xenopus laevis after change of background colour.


The estimation of plasma 11-deoxycorticosterone in man using gas-liquid chromatography with electron capture detection.


Effects of oestrogen and progesterone on the development, oviductal transport and uterine retention of eggs in hypophysectomized pregnant rats.


Neurophysins of the human pituitary gland.


Glucagon in the foetal sheep.

Glucagon in the foetal sheep.


Ovarian 20 -hydroxysteroid dehydrogenase in the parturient mouse.


Isolation of rat neurohypophysial proteins and their tentative identification as neurophysins.


Lack of effect of the uterus on the luteolytic effect of luteinizing hormone in the rat.


The effects of the smoking process on cannabinols.


Murder or suicide? A case report.

Murder or suicide? A case report.


Some perspectives in 'cot death'.

Some perspectives in 'cot death'.


Exsanguinating hemoptysis due to a ruptured syphilitic aneurysm.


Role of the epiglottis in anaesthetic deaths.


Psychiatry sociopathy and the XYY chromosome syndrome.


Rifampin and other drugs for treatment of tuberculosis.


Acetaminophen, valadol, and analgesic renal injury.


Hospitals in Sweden. Karolinska Hospital is site of Swedish computer study.


Hospitals in Sweden. Computer at Danderyd will help provide health care by the numbers.


Hospitals in Sweden. Huddinge Hospital:  200 million of health care.


Swedish hospital products help improve quality of care.


Leasing: a way to use equipment without buying it.


New furnishings system says "Hang it all".


Rent-a-nurse for hospital or home care.

Rent-a-nurse for hospital or home care.


Rx: drug information center.

Rx: drug information center.


Turning point? Study indicates hosptial utilization declining.


Errors in handling can make sterile disposables unsafe.


Written record of telephone messages helps reduce errors and misunderstandings.


More myths about mismanagement.

More myths about mismanagement.


Liability nightmares: power fails in the O.R., patient refuses transfusion.


Buyer's guide to laws of title, fraud, arbitration, leasing.


What you need to know before job interview.


New hospital will offer private accommodations in a semi-private room.


The natural history of congestive heart failure: the Framingham study.


Acute hemolytic anemia with rigid red cells in hypophosphatemia.


On the "principles of the heart" and the psychiatric insights of Zen.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 51-1971.


New cultures and sensitivities.

New cultures and sensitivities.


Hazards of indiscriminate screening for sickling.


Achlorhydria and ulcer.

Achlorhydria and ulcer.


Hyperglycemia after diazoxide.

Hyperglycemia after diazoxide.


Diagnosis of cryptococcal meningitis.

Diagnosis of cryptococcal meningitis.


Bartter's syndrome in blacks.

Bartter's syndrome in blacks.


Hyperuricemia and levodopa.

Hyperuricemia and levodopa.


Urethral stone managed with Fogarty catheter.


Granulated sugar as treatment for hiccups in conscious patients.


Diameter of testicles.

Diameter of testicles.


Sleep and depressive syndromes.

Sleep and depressive syndromes.


Female feldshers fusilladed.

Female feldshers fusilladed.


Disenchantment with SAMA.

Disenchantment with SAMA.


Careers in nursing. Join the Army and see the world.


Infanticide.

Infanticide.


Aftermath of retention with overflow.

Aftermath of retention with overflow.


A chance for the nursing profession?

A chance for the nursing profession?


Sit down and listen.

Sit down and listen.


What makes an addict?

What makes an addict?


The learning process in student nurses. 2.


Lysistrata takes another look at health visitors.


Notes on motivations for war. Toward a psychoanalytic social psychology.


Depersonalization and the masochistic wish.


Wrist scratching as a symptom of anhedonia: a predepressive state.


Teaching the beginner. 'Baptism by fire'.


A new cystographic method with 'uro spray'.


Two rare variants of the arteries in the circle of Willis.


Cerebral angioautotomography.

Cerebral angioautotomography.


Automated exposures in contemporary radiography.


The plight of radiologic technology: quantity and quality.


The bronchial brushing procedure.

The bronchial brushing procedure.


Improved silver recovery equipment.

Improved silver recovery equipment.


Hard hats in space.

Hard hats in space.


High voltage warning device for color television.


Opaque medication.

Opaque medication.


Seatbelts and frail humans.

Seatbelts and frail humans.


Mathematics and the medical profession.

Mathematics and the medical profession.


Squamous carcinoma of the paranasal sinuses in the Bantu.


Cephalexin: clinical and laboratory studies.


Bladder emptying flow rate as a function of bladder volume.


Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart.


Experimental endocarditis. 3. Natural history of catheter induced staphylococcal endocarditis following catheter removal.


Spontaneous pubertal breast growth in a castrated patient with the syndrome of testicular feminization.


[Stability of the personality structur in children based on questionnaire (Q) data measurements].


Preparation and chemical analyses of a lipoprotein concentrate from niger seed (Guizotia abyssinica Cass.).


Syringobulbia--prolonged survival.

Syringobulbia--prolonged survival.


Selective angiography of the external carotid artery and its branches by catheterization of the superficial temporal artery.


Isolation, purification, and characterization of a maltotetraose-producing amylase from Pseudomonas stutzeri.


Marine bacterial proteases. II. Peptide specificity of an endopeptidase produced by Vibrio B-30.


Peroxidase catalyzed reactions of iodide at low pH.


The purification and properties of the glycoproteins of pig gallbladder bile.


Changes in oxidation-reduction potential of cytochrome b observed in the presence of antimycin A.


Studies of adrenal steroid hydroxylation. I. Purification of the microsomal 21-hydroxylase system.


The glucose-glucose 6-phosphate exchange catalyzed by yeast hexokinase.


Characterization of zonal fractions of calf thymus DNA.


The removal of organic phosphates from hemoglobin.


Effect of pyridine on the light-induced pH rise and postillumination ATP synthesis in chloroplasts.


On the comparison of the qualities of thermographic apparatuses.


Biochemical aspects of the visual process. XIV. The binding site of retinaldehyde in rhodopsin studied with model aldimines.


RNA metabolism in rat intestinal mucosa of normal and vitamin A-deficient rats.


Regulation of porphyrin biosynthesis in the harderian gland of inbred mouse strains.


Dry cleaning polyesters.

Dry cleaning polyesters.


Localization of trehalase in flight muscle of the blowfly Phormia regina.


Purification of  -L-fucosidase from the liver of a marine gastropod, Turbo cornutus, and its action on blood group substances.


Effects of 5'-adenylic acid on firefly luciferase.


Exposure of formulating plant workers to DDT.


Biosynthetic L-threonine deaminase from Bacillus stearothermophilus. I. Catalytic and regulatory properties.


Aldrin and Dieldrin in human blood components.


Evidence of antitumorigenic effects of DDT.


Occurrence of alkylmercury compound in caustic soda factory.


Trace metal content of hair. I. Zinc and copper content of human hair in relation to age and sex.


Regional variation in percutaneous penetration in man. Pesticides.


Effect of oxygen lack on tracheal ciliary activity in vivo and in vitro.


Prevalence of chronic respiratory disease. Asbestosis in ship repair workers.


Preventive medicine in a private group practice setting. A new department: community medicine.


The status of byssinosis in the United States. A summary of the National Conference on Cotton Dust and Health and the recommendations of the organizing committee.


Isoniazid prophylaxis and BCG vaccination in the control of tuberculosis. High-risk groups.


Fine structure of 7,12-dimethylbenz(a)anthracene-induced rhabdomyoblastoma in Syrian hamster.


Oxygen availability in the human myocardium recorded with chronically implanted electrodes.


Oxidation of several aromatic hydrocarbons using dimethyl sulfoxide exposed to the atmosphere.


Multiple control mechanisms for succinate dehydrogenase in mitochondria.


Bleaching of rhodopsin in the dark.

Bleaching of rhodopsin in the dark.


Construction of a three-dimensional iso-density map of the low-density lipoprotein particle from human serum.


Independent synthesis of small and large subunits of myosin in vivo.


Purification of dihydrofolic reductase from chicken liver by affinity chromatography.


Mass spectra of antibiotics, deoxynigericin and nigericin.


Interaction of erythrocyte apoprotein with bimolecular lipid membranes.


The effect of solvent on the fluorescence of Schiff bases of pyridoxal 5' phosphate.


A correlation of intracellular cerebroside sulfatase activity in fibroblasts with latency in metachromatic leukodystrophy.


The purification of S-adenoxyl-L-methionine decarboxylase from rat liver: inability to separate decarboxylation from spermidine synthesis.


Effect of inositol hexaphosphate and other organic phosphates on the cooperativity in oxygen binding of human hemoglobins.


Amino acid sequence of  -bungarotoxin from the venom of Bungarus multicinctus.


Conformational and activity changes on subtilisin cleavage of carboxypeptidase A.


Isolation and characterization of a peptide synthesized in mitochondria.


An unusual citrate synthase from mango fruit.


On the specificity of tryptic catalysis.


Crystalline kynureninase from Pseudomonas marginalis.


Naphthol AS-D chloroacetate esterases in granule extracts from human neutrophil leukocytes.


The nature of complex formation. In: molecular properties of drug receptors.


The production of lymphocyte mitogenic factor and migration-inhibition factor by antigen-stimulated lymphocytes of subjects with grass pollen allergy.


The bubble point in membrane characterization.


Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases.


Elimination of contamination from personnel in sterile manufacturing areas.


Effect of ileal resection on bile salt metabolism in patients with ileostomy following proctocolectomy.


On the mechanism of hyperkalaemia due to hyperosmotic expansion with saline or mannitol.


The plasma clearance and liver uptake of iron from transferrin of low and high iron saturation.


Thermodynamic and kinetic aspects of parenteral benzodiazepines.


Considerations in the production and control of virus vaccines.


The effect of ammonium salts on cerebral and hind-limb consumption of oxygen and glucose in the ventilated dog.


Rates of absorption by rat intestine of pancreatic hydrolysates of proteins and their corresponding amino acid mixtures.


The reflex stimulation of catecholamine secretion during the acute stage of myocardial infarction in the dog.


The role of vasopressin and urea in the renal concentrating defect of patients with cirrhosis of the liver.


Seasonal influence on insulin secretion in man.


The excretion of salicylate in salicylate poisoning.


Civilian colonic injuries and current surgical management.


Anxiety, depression and psychotropic drugs.


Effect of corticosteroid treatment on lymph oxygen tension in hemorrhagic shock.


The relationship between haemodynamic changes and some aspects of cardiac metabolism during hemorrhagic shock in the unanaesthetized dog.


Regional blood flow studies with labelled microspheres of different sizes in dogs with and without occlusion of the common bile duct.


The effect of sulfhydryl compounds on the stability of cell membranes of the lens and red cells and of the lens capsule.


Protein-SH and protein-bound sugar in the lens.


Histochemistry of protein sulfhydryl and disulfide groups in the lens.


Proteins in human endometrial washings--a preliminary report.


Biochemistry of cervical mucus: a comparative analysis of the secretion from preovulatory, postovulatory, and pregnancy periods.


Mating, fertilization, and ovum viability in the anovulatory, persistent-estrus rat.


On the mechanism of action of oral contraceptives. I. Effect of lynestrenol on ovum implantation and oviductal morphology in the rat. 2 experiments on virgin female rats (average weight 200 gm) were performed to study the effects of small doses of lynestrenol on the early pregnancy of the rat.  In both experiments, the rats were caged with a mate overnight and if, on the following morning, spermatozoa were found on the vaginal smear, that day became Day 1 of pregnancy.  In Experiment 1, the test group (15) received .1 mg lynestrenol sc and the control group (14) 1 ml propyleneglycol on Days 2, 3, 4, and 5 of pregnancy.  Experiment 2 differed in that the rats received 1 mg dosages of lynestrenol.  On Day 7 of pregnancy, Experiment 1 rats were killed and their ovaries and genital tracts were examined.  In Experiment 2, the rats were permitted to live until Day 23 to see if they would achieve full-term pregnancy.  If delivery did not occur, they were killed (Day 25) and examined for fetuses.  In Experiment 1, the dose did not significantly increase the number of lost ova (20% in controls), as indicated by the implanted embryos/recent corpora lutea ratio counted on Day 7.  There was an increase in the number of ciliated cells in the epithelium and a diminution of the deciduoid tissue of the stroma.  No histological changes were seen in the ovaries, embyros, or uteri.  The 1 mg dosage of lynestrenol prevented pregnancy in all of the rats.  Doses were smaller than those needed to inhibit ovulation, and the time of administration of the doses excluded any action on sperm transport, capacitation, or penetration.  Lynestrenol would appear to act on the pregnant rat's genital tract, as oviducts displayed evidence of estrogen stimulation.


Reproductive ability and progeny of F 1  lead-toxic rats. The relationship of chronic lead ingestion and reduced reproductive performance was investigated with regard to the relative paternal and maternal effect of lead as measured by the progeny of F-one lead toxic rats.  Paternal lead-toxic effect on pups' development was manifested by a retardation of embroynic growth and a reduction in the number of weaned pups per litter.  The maternal effects of lead toxicity were seen in reduced litter size, retardation of fetal development and impaired postnatal survival.  When both maternal and paternal effects of lead toxicity coexisted, all previously identified components were manifested and resulted in the birth of a few, precariously small pups which had a 30% survival rate.  The effects of lead upon reproduction in the rat can be classified as gametotoxic, intrauterine and extrauterine.


Chromatin-negative Klinefelter's syndrome with normal testes and serum gonadotropins and testosterone.


Enzyme activities in the seminal plasma of patients with sex-chromosome abnormalities.


Mode of formation of giant cells in testicular hyperthermia.


The Veterans Administration Cooperative Study on Gastric Ulcer. 10. Resume and comment.


Neural crest origin of the endocrine polypeptide (APUD) cells of the gastrointestinal tract and pancreas. A method of labelling known to be appropriate for the demonstration of endocrine polypeptide (APUD) cells was found to label the cells of the neural crest in the chick embryo after as little as 72 hours' development. The method depends on the production, from an exogenous precursor, of an amine which is stored in specific granules and which is convertible by treatment with hot formaldehyde vapour into a fluorescent derivative. The whole technique is described as APUD-FIF. The application of APUD-FIF to mouse embryos shows that at the 7-8 somite stage (eight days) labelled neural crest cells migrate in large masses in a ventrad direction. At around the ninth day they colonize the developing foregut and its derivatives, including pharynx, stomach, duodenum, ultimobranchial body, and pancreas. In subsequent stages of development (up to 12 days) the cells are seen in comparatively large numbers in the gastrointestinal tract and in the pancreas. Complete proof that these early APUD cells, which demonstrably arise from the neural crest, are the precursors of all the endocrine polypeptide cells of the adult pancreas, stomach, duodenum, and small and large intestine, is not at present available. Notwithstanding a great deal of earlier evidence to the contrary, the premise seems likely to be true.


Intramural cysts of the ileum.

Intramural cysts of the ileum. A case of intramural cysts of the ileum is described for the first time. The clinical presentation and pathological findings are presented and the possible aetiology is discussed.


Incidence of small-intestinal mucosal abnormalities and of clinical coeliac disease in the relatives of children with coeliac disease. Evidence is presented of a higher than normal incidence both of clinical coeliac disease and of small-intestinal mucosal abnormalities in relatives of children with coeliac disease. In such relatives the incidence of mucosal abnormality may differ from the incidence of clinical coeliac disease. The data show an absence of any simple Mendelian pattern of inheritance: in place of the hypothesis that inheritance is through a dominant gene of reduced penetrance, it is argued that the pathogenesis of coeliac disease is multifactorial, the genetic basis of susceptibility being polygenic and interacting with environmental factors. On this hypothesis the relative contributions of inheritance and environment to liability to the clinical condition are estimated, the genetic component being 45% +/- 9. Environmental factors appear more important in the development of mucosal abnormality.


The fate of pentagastrin.

The fate of pentagastrin. Pentagastrin is rapidly removed from the circulation of the dog. It is excreted by the liver into the bile, largely in an inactivated form. Preliminary results indicate that it meets the same fate in man.


Potassium transport in the human small bowel. Factors influencing transport of potassium in the human small bowel were studied using perfusion techniques in normal subjects and in patients with ileostomies.  In the small intestine of normal subjects and in the ileum of ileostomy patients, potassium is distributed across the mucose in a passive transport process.  Potassium transport in the jejunum was influenced to a large degree by solvent drag.  The mucosa of the jejunum seems more permeable to potassium than to sodium, and this permeability was apparently unaffected by calcium in the lumen in concentrations of 1.15-7.25 mEq/liter. Potassium transport in the ileum was influenced by luminal sodium concentration, suggesting that this is a passive consequence of the change in electrical potential induced by the change in sodium concentration.  In this way, the electrical potential is thought to be a sodium diffusion potential.  Therefore, all evidence points to a purely passive behavior of the small intestine toward potassium.


Portal hypertension in primary biliary cirrhosis. Evidence of portal hypertension was found in 50 out of 109 patients (47%) with primary biliary cirrhosis, and of these 32 bled from oesophageal varices. In four patients portal hypertension was the initial manifestation of the disease and this complication was recognized in a further 17 within two years of the first symptom of primary biliary cirrhosis. The development of portal hypertension was associated with a poor prognosis and death could frequently be attributed to variceal bleeding; the mean duration of survival from the time that portal hypertension was recognized was 14.9 months. Portal decompression operations may have improved the immediate prognosis in some patients but did not otherwise influence the progression of the disease. In 47 patients the histological findings in wedge biopsy or necropsy material were correlated with the presence or absence of varices. An association between nodular regeneration of the liver and varices was confirmed, but, in the absence of nodules, no other histological cause for portal venous obstruction could be found.


Gastroenterostomy--an obsolete operation?


The breakdown of dietary cellulose in man.


Ultra-active treatment of haematemesis and melaena.


The influence of amino acids on sodium and water absorption from the small intestine.


Effects of prostaglandin E1 on net and unidirectional movements of water and electrolytes across the jejunal mucosa in man.


Effects of bile acids on small intestinal absorption of glucose, water, and sodium.


Sugar absorption studied by an exsorption technique.


The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat.


Preoperative prediction of success or failure of gastric surgery.


Genetic factors in the development of duodenal ulcer in childhood.


Some genetic aspects of coeliac disease and dermatitis herpetiformis.


Diagnostic tests for the stagnant loop syndrome.


Intrajejunal volatile fatty acids in gastrointestinal disease.


Fatal malabsorption unresponsive to gluten-free diet in the adult.


Autoantibodies to reticulin in patients with various gastrointestinal diseases and their relationship to immunoglobulins and dietary antibodies.


Studies of cellular immunity of liver diseases.


Incidence and pathogenesis of multisystem involvement in chronic liver disease.


Effect of insulin hypoglycaemia on plasma gastrin concentration and gastric acid secretion in normal subjects.


Glucagon and the gut.

Glucagon and the gut.


Pancreozymin and secretin in the control of pancreatic exocrine secretion.


Amylase secretion and calcium efflux from isolated rat pancreas.


Hepatic structure and function in psoriasis before and after treatment with methotrexate.


Quantitative analysis of the ultrasonic liver scan.


The production and transport of ammonia in the human colon.


The effect of acute biliary obstruction on hepatic cholesterol biosynthesis in the cholesterol-fed rat.


Treatment and prognosis in diffuse jejuno-ileitis.


Crohn's disease of the mouth and lips.

Crohn's disease of the mouth and lips.


The anal lesion as the sole presenting symptom of intestinal Crohn's disease.


Does highly selective vagotomy preserve antral motility?


The prevention of post-vagotomy diarrhoea.


Evidence for partial vagal reinnervation of the stomach after highly selective vagotomy without a drainage procedure (HSV) for duodenal ulcer in man.


Studies in the rates of epithelial cell exfoliation from the gastric mucosa in normal and in ulcer subjects.


The demonstration of polypeptide hormone-secreting cells in the gastrointestinal tract.


Histopathology of cathartic colon.

Histopathology of cathartic colon.


Scientific subcommittee of the British Society of Gastroenterology. Study of severity in ulcerative colitis; interim report.


Experimental ulceration of the colon induced by non-algal sulphated products.


Intravascular coagulation in acute hepatic necrosis: clinical and experimental studies into the deposition of microthrombi and the effect of treatment.


Further observations on the Lundh test meal in the diagnosis of pancreatic disease.


Gastrointestinal iron losses in atrophic gastritis, postgastrectomy states and adult coeliac disease.


Congenital athetosis, mental deficiency, dwarfism and laxity of skin and ligaments.


Syndrome of phocomelia with mandibular hypoplasia.


The effect of the ingestion of acetylsalicylic acid on platelet function in normal children.


Surgical progressive care unit.

Surgical progressive care unit.


Hospital shared services.

Hospital shared services.


Preadmission testing.

Preadmission testing.


Drug abuse programs: are hospitals too late and too square?


Volunteers: role in alcoholism program.

Volunteers: role in alcoholism program.


Hospital schools of nursing.

Hospital schools of nursing.


Clinical pharmacy training.

Clinical pharmacy training.


Electrical shock hazards. 2.

Electrical shock hazards. 2.


Food service: research on assembly-serve systems.


Guidelines for purchasing convenience foods.


Gas sterilization and packaging.

Gas sterilization and packaging.


The virulence of original and derived strains of Semliki forest virus for mice, guinea-pigs and rabbits.


Reovirus: analysis of proteins from released and cell-associated virus.


The structure, origin, isolation, and composition of the tubular mastigonemes of the Ochromas flagellum. The structure, assembly, and composition of the extracellular hairs (mastigonemes) of Ochromonas are detailed in this report. These mastigonemes form two lateral unbalanced rows, each row on opposite sides of the long anterior flagellum. Each mastigoneme consists of lateral filaments of two distinct sizes attached to a tubular shaft. The shaft is further differentiated into a basal region at one end and a group of from one to three terminal filaments at the free end. Mastigoneme ontogeny as revealed especially in deflagellated and regenerating cells appears to begin by assembly of the basal region and shaft within the perinuclear continuum. However, addition of lateral filaments to the shaft and extrusion of the mastigonemes to the cell surface is mediated by the Golgi complex. The ultimate distribution of mastigonemes on the flagellar surface seems to be the result of extrusion of mastigonemes near the base of the flagellum, and it is suggested that mastigonemes are then pulled up the flagellum as the axoneme elongates. Efforts to characterize mastigonemes biochemically after isolation and purification on cesium chloride (CsCl) followed by electrophoresis on acrylamide gels have demonstrated what appear to be a single major polypeptide and several differentially migrating carbohydrates. The polypeptide is not homologous with microtuble protein. The functionally anomalous role of mastigonemes in reversing flagellar thrust is discussed in relation to their distribution relative to flagellar anatomy and to the plane of flagellar undulations.


Studies with avian influenza A viruses: cross protection experiments in chickens.


The incorporation of  14 C-leucine into the proteins of plucked wool follicles.


Structural organization of the stratum corneum in certain scaling disorders of the skin.


The isolation of dimethyl sulfoxide soluble components from human epidermal preparations: a possible mechanism of action of dimethyl sulfoxide in effecting percutaneous migration phenomena.


The effect of actinomycin D on the incorporation of labeled vitamin A acid in normal and tumor epithelium.


The biochemical property and physiologic significance of deoxyribonuclease in the epidermis. I. Partial purification and properties of DNase isolated from cow snout epidermis.


Oxygen supply and stability of chromosomes in mouse embryo cells in vitro.


Growth inhibition of rat mammary carcinoma induced by cis-platinum diamminodichloride-II.


Spontaneous feline fibrosarcomas: transmissibility and ultrastructure of associated virus-like particles.


Histopathology of renal lipomatous tumors in rats treated with the "natural" products, pyrrolizidine alkaloids and  , -unsaturated aldehydes.


Effect of neuraminidase on growth of a 3-methylcholanthrene-induced fibrosarcoma in normal and immunosuppressed syngeneic mice.


Age at menarche and breast cancer.

Age at menarche and breast cancer.


Some neglected leads to cancer causation.


Effect of cytosine arabinoside and 1,3-bis(2-chloroethyl)-1-nitrosourea on hematopoietic precursors in the mouse.


Undergraduate curriculum: a success.

Undergraduate curriculum: a success.


The romance is floundering.

The romance is floundering.


Crises of the deaf.

Crises of the deaf.


The forgotten concept.

The forgotten concept.


Consumer participation.

Consumer participation.


Bureaucracy. Threat or challenge?

Bureaucracy. Threat or challenge?


[Fracture of the femur neck in coxa valga. Apropos of 45 cases].


Sanity in research and evaluation of environmental health.


Mercury in a Greenland ice sheet: evidence of recent input by man. The increased mercury content in a Greenland ice sheet over the last several decades suggests the dissemination of this element about the earth's atmosphere through the activities of man. The mercury content in the atmosphere appears to result primarily from the degassing of the earth's crust. Increased flux may come about as a result of the enhancement of this degassing process through the actions of man.


Viral RNA polymerases: electron microscopy of reovirus reaction cores. The Kleinschmidt technique has been used to observe reovirus cores that have synthesized messenger RNA. Some individual viral cores probably synthesize all ten messenger RNA molecules in vitro. Each messenger RNA molecule appears to be attached to a different site on the core surface, implying that there are probably a number of different enzymic sites in each core.


Acridine orange potentiation of actinomycin D uptake and activity. Acridine orange enhances the uptake of [(3)H]actinomycin D in disrupted and intact human lymphocytes, as measured by liquid scintillation and autoradiography. Proflavine, quinacrine, chloroquine, and ethidium bromide are not effective. In mice, acridine orange increases the capacity of actinomycin to reduce spleen weight. Type II acridine binding to DNA may be a prerequisite for actinomycin enhancement.


Adult hemoglobin synthesis by reticulocytes from the human fetus at midtrimester. The synthesis of adult-type hemoglobin was measured in small samples of peripheral blood cells from 9- to 18-week human fetuses. Hemoglobin indistinguishable from hemoglobin A was identified by ion-exchange chromatography, electrophoresis at pH 8.6, tryptic peptide analysis, and the insensitivity of its synthesis to the action of O-methylthreonine. Synthesis of hemoglobin A accounted for 8 to 14 percent of total hemoglobin synthesis and was demonstrated in as little as 10 microliters of fetal blood. These studies provide sensitive methods for the detection of beta chain types in hemoglobin synthesized by the human fetus at midtrimester. If methods to obtain small quantities of fetal blood at midtrimester become available, these techniques should be applicable to the antenatal detection of sickle cell anemia and related hemoglobinopathies.


Polymorphism of human constitutive heterochromatin. Genetic polymorphism has been demonstrated in man for many characteristics including blood groups, serum proteins, tissue enzymes, and hemoglobins. A class of chromosomal polymorphism involving constitutive heterochromatin has now been found. Through the use of a special technique that permits visualization of heterochromatin, seven heterochromatin variants have been found among four individuals. These results suggest a very high frequency of variability of heterochromatin in the population.


Herpesvirus type 2 isolated from cervical tumor cells grown in tissue culture. A herpesvirus has been isolated from spontaneously degenerating cultures of cervical tumor cells grown in vitro. The virus was identified as a type 2 herpesvirus on the basis of biologic properties, including plaque morphology and microtubule formation in infected HEp-2 cells, and of immunologic specificity as determined by neutralization. Herpesvirus antigens and virus particles were not seen in duplicate cultures of viable cervical tumor cells.


Mendelian and uniparental alterations in erythromycin binding by plastid ribosomes. Erythromycin binds specifically to the 52S subunit of the chloroplast ribosome of Chlamydomonas reinhardi. A number of erythromycin-resistant mutants whose ribosomes have lost their affinity for the antibiotic have been isolated, but the sedimentation properties of their ribosomes are indistinguishable from those of the wild-type strain. These mutants represent at least three genetic loci. Two of them show Mendelian inheritance, and one of them is inherited in a uniparental manner.


Creation of "amyloid" fibrils from Bence Jones proteins in vitro. "Amyloid" fibrils have been created from some human Bence Jones proteins by proteolytic digestion under physiologic conditions. These fibrils with an antiparallel, beta-pleated sheet conformation consist of only a portion of the variable region of the immunoglobulin light polypeptide chain and share the physical properties of amyloid fibrils. The relation between amyloidosis and immunoglobulins is thus more firmly established and a pathogenetic mechanism for amyloid fibril formation is suggested.


Ascorbic acid: a culture requirement for colony formation by mouse plasmacytoma cells. Plasmacytoma stem cells explanted from mice formed colonies in culture only in the presence of L-ascorbic acid; this vitamin was not needed for the formation of granulocytic colonies. Isomers of L-ascorbic acid with less antiscorbutic activity also promoted plasmacytoma colony formation, but less effectively. Other redox compounds without antiscorbutic activity and an antioxidant were ineffective.


The brain as a parallel coherent detector. Knowledge of the bioelectric signal-to-noise ratios in rat brain makes it possible to demonstrate for the first time that the brain functions as a coherent signal detector, an important class of detectors that are explicitly formulated within the statistical theory of communication. Within an afferent neuronal channel of a single modality, the brain functions as a parallel signal processor.


Phenothiazine effects on auditory signal detection in paranoid and nonparanoid schizophrenics. The differential effects of phenothiazine medication on auditory signal detection performance were compared in two types of schizophrenic subjects and in normal subjects. With increasing phenothiazine dosage a decrease in efficiency of signal detection performance occurred among nonparanoid schizophrenics and an increase in efficiency occurred among paranoid schizophrenics. These and related findings were interpreted in terms of differences in neuropsychological response and information processing characteristics in the two types of schizophrenics. The primary deficit in information processing in nonparanoid schizophrenics may be related primarily to their hypersensitivity to sensory stimuli, whereas in paranoids it may be related primarily to their impaired focusing of attention. Phenothiazines appear to decrease sensitivity to stimuli in nonparanoids but increase the ability to focus attention in paranoids. The possibility of treatment regimens which take into account the differential effects of phenothiazine medication was suggested.


Major plasma lipids and their fatty acid composition in multiple sclerosis and other neurological diseases.


The relation of retinal periphlebitis to multiple sclerosis and other neurological disorders.


The prevalence of multiple sclerosis in New Zealand.


The time-course of intracranial hypertension as recorded in conscious rabbits after treatment with different amounts of intracisternally injected kaolin.


Relation between intracranial pressure and ventricular size at various stages of experimental hydrocephalus.


Brain concentrations of dopamine, noradrenaline, 5-hydroxytryptamine, and homovanillic acid during intracranial hypertension following traumatic brain injury in rabbit.


Nervous system manifestations after gastric surgery.


Virus serology and serum IgE levels in children with asthmatoid bronchitis.


Plasma calcium fractions in normal subjects from birth to adult ages.


Metabolic alkalosis in infants: role of water depletion and changes in composition of stool. Review of a physiological problem.


Concentration of purine nucleotides in erythrocytes of patients with the Lesch-Nyhan syndrome before and during oral administration of adenine.


Anaphylaxis and red cell survival studies in a child with insulin-resistant diabetes mellitus.


An epidemiological study of child health and nutrition in a northern Swedish county. 3. Medical and anthropometrical examinations.


The incidence of Pku in Finland.

The incidence of Pku in Finland.


Renal function tests in nonacute recurrent urinary tract infections in children.


Influence of long term growth hormone therapy on glucose tolerance and insulin secretion.


Studies on maturity in newborn infants. I. Birth weight, crown-heel length, head circumference and skull diameters in relation to gestational age.


The influence of orotic acid on the serum bilirubin level of mature newborn.


Control of sodium homeostasis in children with recurrent urinary tract infections and reduced glomerular filtration rates.


Adhesions of labia minora (synechia vulvae) in childhood. A review and report of fourteen cases.


Congenital leukaemia.

Congenital leukaemia.


Identification of the Y chromosome by the fluorescence technique in an XY-X0 gonadal dysgenesis.


Recurrent abdominal pain in children: a review of somatic aspects.


Recurrent abdominal pain in children: psychiatric aspects.


Acute suprarenal cortical insufficiency in infancy. A case of congenital isolated hypoaldosteronism.


Infections with mycoplasma pneumoniae in children.


Radiographic changes in acyanotic heart disease in infants.


Demonstration of four patients with good recovery from infantile spasms and hypsarrhythmia.


Malformations of the urinary tract in children with urinary infections.


Vesico-ureteric reflux in children.

Vesico-ureteric reflux in children.


Necrosis of tumour cells related to circulatory insufficiency in pulmonary tumour embolism.


Histology of the induction phase of the primary immune response in lymph nodes of germfree mice.


Primary sarcoma of the heart. A case report.


The intrarenal vascular alterations in radiation nephritis and their relationship to the development of hypertension.


Hepatic changes in dogs and rats induced by xylidine isomers.


Adenoma of the nipple with carcinomatous development.


Karyotypic profile alterations in Ehrlich ascites tumour cells during development of resistance to daunorubicine.


Lung biopsy diagnosis of secondary vascular lesions in congenital heart disease.


Nodular fasciitis.

Nodular fasciitis.


Basal cell adenomas of salivary glands.

Basal cell adenomas of salivary glands.


The microembolism syndrome.

The microembolism syndrome.


C-cell hyperplasia in a case with primary hyperparathyroidism.


Parathyroid cell growth and proliferation in nephrectomised rats.


Changes in the vagus nerve in diabetes mellitus.


Methylcholanthrene-induced skin carcinogenesis modified by treatment with polyinosinic:polycytidylic acid (poly I:C).


Chemical epidemiological aspects of pesticides.


[Accidental intra-arterial injection during a sclerosing treatment of varicose veins: apropos of a case].


[Medical control of health insurance in the German Federal Republic (its development)].


[Acute cryptoleukosis of benzene-induced refractory anemia (2 further cases)].


A crude nuclease preparation suitable for use in DNA reassociation experiments.


The effect of calcium on in vitro polyphenylalanine synthesis by rice ribosomes.


Cytoplasmic and nuclear basic protein synthesis during early sea urchin development.


Free and bound hepatic polyribosomes after partial hepatectomy: pool sizes and sedimentation patterns.


Contrast of liver and lymphoid tissue ribonucleases.


Uptake and release of free amino acids by starfishes.


Blood lymphocyte replicating ability as a measurement of radiation dosage.


Blood flow and volume measurements in the radiation depopulated testis of the rat.


The area ration of normal aortic junctions. Aortic configuration and pulse-wave reflection.


The radiological assessment of disease of the profunda femoris artery.


The use of ultrasound in the diagnosis of renal disease.


Combined pancreas and liver scanning using a double isotope technique.


Adult multicystic renal disease.

Adult multicystic renal disease.


The optimum injection-to-scan interval for spinal scans using  87 Sr m .


Renal carcinoma diagnosed by cyst puncture: a case of mistaken identity.


Spring-operated injector in intravenous urography.


Calculus in a Meckel's diverticulum--a preoperative radiological diagnosis.


Manufacture of lead shields.

Manufacture of lead shields.


Thermography as an aid in the diagnosis of tumours and detection of metastatic bone disease.


A comparison of conventional skeletal radiography with isotope bone scans mainly using  87 Sr m .


The relative merits of thermoscanning and gamma scanning in the detection of metastatic bone disease.


Radiological evaluation of bony metastases from breast cancer.


Percutaneous nephrostomy.

Percutaneous nephrostomy.


The role of excretion urography in clinical practice.


Renography and the distinction between renovascular and non-renovascular hypertension.


Xerographic recording of x-ray images.

Xerographic recording of x-ray images.


Some aspects of phlebographic technique.


Stereoscopic measurement in mammography.


Three-dimensional x-ray images using holographic techniques.


An integrated system for x-ray records and film sorting.


The development of the  252 Cf radiotherapy programme.


Radiobiological background for use of  252 Cf sources--the data available at present.


Californium--rads, rems and riddles.

Californium--rads, rems and riddles.


Experience with  252 Cf in radiotherapy.

Experience with  252 Cf in radiotherapy.


252 Cf dosimetry.

252 Cf dosimetry.


Proposals for the clinical assessment of  252 Cf in Manchester.


Introduction: attributes of human cancer to be considered in seeking animal models.


Clinical evidence suggesting host defence mechanisms in Burkitt's lymphoma and Kaposi's sarcoma.


The reckoning of host defence against cancer.


The plateau phase culture as an in vitro model for human cancer.


General methods of evaluating absorbed dose.


Comparison of responses of animal tumours and human tumours to various treatments with ionizing radiations.


The acquisition and analysis of biological and human data.


Microscopic dose distribution due to  125 I in the thyroid.


Application of cavity theory to the dosimetry of bone-seeking radioisotopes.


Dosimetry of  3 H and  14 C compounds.

Dosimetry of  3 H and  14 C compounds.


Clinical progression of ocular syphilis and neurosyphilis despite treatment with massive doses of penicillin. Failure to demonstrate treponemes in affected tissues.


Variations in serum concentrations of penicillin after injections of aqueous procaine penicillin G with and without oral probenecid.


Present state of gonorrhoea control.

Present state of gonorrhoea control.


Anal warts and anal coitus.

Anal warts and anal coitus.


Factors with increase the spread of gonorrhoea.


Epidemiological trend of gonorrhoea in recent years.


Epidemiological aspects of gonococcal infections in Dakar.


Epidemiological and therapeutic data on gonorrhoea in Genoa and other parts of Italy.


Considerations on gonorrhoea in the Middle East.


Problems concerning gonorrhoea in Austria.


Aspects of the present problem of gonorrhoea in Spain.


Influence of gonococcal urethritis in men and their psychiatric state.


Experience in the treatment of gonorrhoea with penicillin.


Single-dose treatment of gonorrhoea with penicillin or thiamphenicol and its effect on T. pallidum in experimental syphilis.


Results of the 'minute' treatment of gonorrhoea.


Treatment practices in gonorrhoea in the United Kingdom.


Studies on stability of drugs in frozen systems. 3. The hydroxyl ion-catalyzed decomposition of benzylpenicillin sodium in frozen aqueous solution.


An improved method for the determination of human pregnancy serum oxytocinase activity.


Origin and termination of cuneocerebellar tract.


Organization of afferent connections to cuneocerebellar tract.


Physiological responses of frog vestibular fibers to horizontal angular rotation.