Variations in the permeability properties of the inhibitory post-synaptic membrane of the crayfish neuromuscular junction when activated by different concentrations of GABA. 1. The membrane conductance of the crayfish muscle was measured with intracellular micro-electrodes. Increase in the membrane conductance induced by various concentrations of gamma-amino butyric acid (GABA) was measured in the Br(-), NO(3) (-), I(-) and CNS(-) solutions and compared with that in Cl(-) solution. When the membrane was activated by lower concentrations of GABA, the resulting membrane conductance in NO(3) (-) and I(-) solutions was larger than in Cl(-) solution, while the membrane conductance activated by higher concentrations in NO(3) (-) and I(-) solutions were smaller than in Cl(-) solution. The membrane conductance activated by GABA was larger in Br(-) solution and smaller in CNS(-) solution than the membrane conductance activated in Cl(-) solution, throughout the concentration range of GABA examined.2. The reversal potential of inhibitory junctional potentials (i.j.p.s) was measured shortly after replacing Cl(-) by foreign anions: Br(-), NO(3) (-), I(-) and CNS(-). In I(-) solution the i.j.p.s produced by lower stimulation frequencies showed a reversal potential at a more hyperpolarized level than those produced by higher stimulation rates.3. Shortly after replacing Cl(-) by I(-), the GABA potential induced by iontophoretic application showed a triphasic potential change at the ;reversal' potential. The reversal level of the GABA potential produced by smaller doses was at a more hyperpolarized level than that produced by larger doses.4. Possibilities of a concentration effect of GABA are discussed. It is suggested that the relative permeability of the crayfish inhibitory membrane to anions changes depending on the concentration of GABA.


Spontaneous and evoked activity of neurones in the somatosensory thalamus of the waking cat. 1. Adult cats were prepared for chronic micro-electrode recording in the nucleus ventralis posterolateralis (VPL) of the ventrobasal complex (VB) of the thalamus. Spontaneous and evoked activity of single neurones was recorded extracellularly while the animal stood in a hammock. The behavioural state of the animal and the electroencephalogram (e.e.g.) were observed and recorded.2. Three hundred and twenty-five single neurones sensitive to movement of hairs, depression of skin or movement of claws were isolated and studied. Peripheral receptive fields were on the contralateral surface of the body. They remained constant in size and location over long periods of time and despite changes in the behavioural state of the animal. Most of the receptive fields covered a cutaneous area at least as large as an entire paw and many covered an entire limb and extended on to the trunk. These fields are larger than those described by other investigators using natural stimulation in anaesthetized or paralysed animals.3. Moving hairs or touching skin in the peripheral receptive field elicited a burst of spikes at frequencies between 100 and 150/sec. Repeated stimulation did not result in obvious alteration or habituation of the response. There was no apparent change in responsiveness of neurones to peripheral stimulation when the animal was asleep.4. Except for claw-sensitive units, all neurones were active in the absence of intentional stimulation of the receptive field. When the animals were awake, VPL neurones fired more regularly than during sleeping. In slow sleep, with e.e.g. slow waves and spindles, firing patterns were characterized by the presence of more high-frequency bursts of spikes and more long interspike intervals than in waking. Claw-sensitive units, silent during waking, fired in bursts during sleep. When small doses of barbiturate were injected intravenously while recording the activity of neurones, the firing pattern changed to one in which all of the activity occurred in the form of high-frequency bursts. Interburst intervals were variable.5. The level of spontaneous activity in VB in conscious cats is greater than in sensory and sensorimotor cortex to which it projects. The pronounced effect of behavioural state on spontaneous activity of these neurones suggests that the background activity in somatosensory systems may play some role in the processing of afferent input.


Projection from low-threshold muscle afferents of hand and forearm to area 3a of baboon's cortex. 1. The precentral and postcentral banks of the Rolandic fissure of the arm area of the baboon's cortex have been probed to their depths with extracellular micro-electrodes under nitrous oxide and oxygen anaesthesia, supplemented by minimal intravenous pentobarbitone or chloralose.2. Afferent volleys were sent in from the deep (motor) radial nerve and the deep palmar (motor) branch of the ulnar nerve. Their entry into the central nervous system was timed at the dorsal root entry zone. The nerves were stimulated in continuity and the effects of stimuli below threshold for the motor axons were investigated.3. Area 3a, in the depths of the postcentral bank, which is cytoarchitectonically transitional between areas 3 and 4, is the receiving area for afferent impulses from muscle.4. Evoked potential waves and unitary discharges began 4 msec, and the majority of units discharged between 5 and 10 msec, after the afferent volley reached the dorsal root entry zone.5. Similar responses were elicited by a brief pull (70 mu in 1 msec) or brief vibration (50 mu at 250-400 Hz) applied to the tendons of m. extensor digitorum communis.6. No potential waves were evoked in area 4, even in the depths adjacent to area 3a, by muscle afferent volleys.


Different types of extrafusal muscle fibres in snake costocutaneous muscles. 1. Tonic and twitch muscle fibres were identified physiologically in m. costocutanei superiores and inferiores of garter snakes and grass snakes.2. Tonic fibres were multiterminally innervated and showed s.j.p.s in response to nerve stimulation. They did not show propagated A.P.s. They were innervated by motor axons with lower conduction velocities than those to twitch fibres, and often gave a contraction and developed tension in response to a single shock to the nerve. Intracellular square pulse analysis showed that C(m) = 1 muF/cm(2) and R(m) = 40,000 Omega cm(2).3. Twitch fibres showed a conducted action potential in response to nerve stimulation, and focal, as opposed to diffuse, innervation. They showed a variety of isometric twitch contraction times (times-to-peak of about 30-65 msec). Groups of similar motor units contained fibres of approximately similar contraction times. Slow twitch (and tonic) fibres often appeared silvery under dark field illumination, while faster twitch fibres appeared clear. No difference in C(m), R(m) or lambda was found between faster and slow twitch fibres. Values were approximately 3-4 muF/cm(2), 3000-4000 Omega cm(2) and 2 mm respectively.


Induction of labor. I. An invitational symposium.


Computer analysis of labor progression. II. Distribution of data and limits of normal.


Rhodopsin kinetics in the human eye.

Rhodopsin kinetics in the human eye. 1. Rhodopsin has been measured by Rushton's method of reflexion densitometry in a retinal region 18 degrees temporal to the fovea, using a wavelength of measuring light (555 nm) so far into the long wave part of the spectrum that possible blue absorbing intermediates (e.g. transient orange) do not interfere.2. Rhodopsin was bleached by a strong light for 10 sec and then held steady by a weaker light. During a 10 sec bleach, no regeneration occurs and the rate of bleaching is proportional to the quantum catch. The proportionality constant is about 10(-7) (td sec)(-1).3. From 2, the rate of photolysis at equilibrium produced by the steady light was calculated. Since conditions were at equilibrium, photolysis matched regeneration. It was found that the rate of generation was proportional to the amount of pigment still bleached. The proportionality constant was about 0.0025 sec(-1).4. It was found by several different methods that the constant in 3 is the same in the light or dark and hence regeneration occurs independently of bleaching.5. Therefore, the results from bleaching and regeneration experiments can be combined to give the general equation [Formula: see text], where p is the fraction of rhodopsin, t is time in sec and I is the retinal illuminance.6. This equation describes the results of partial bleaching and regeneration experiments under a variety of different exposure intensities of moderately long (at least 10 min) exposure durations.7. The dark adaptation curve in a peripheral region of the rod monochromat's retina where there are few cones follows a simple exponential course over nearly 7 log(10) units. Rhodopsin regeneration and log threshold for this region are described by the same curve with a time constant of about 400 sec. Each log unit fal in threshold is accompanied by 0.835% increase in rhodopsin. This time constant is in agreement with Rushton's (1961) finding, but appreciably longer than that reported by Ripps & Weale (1969a).8. The Ripps & Weale result was, however, obtained by bleaching with a very short bright xenon flash (as they did). Under these conditions, blue absorbing intermediate(s) is (are) formed, the time constant of regeneration of rhodopsin is much faster than after long tungsten bleaches, and the kinetic equation is not valid.9. The general equation, together with the relation found in 7, successfully accounts for results previously published by others of the effect of duration and intensity of bleaching on the recovery of rod threshold in the dark, provided only that more than 5% of the rhodopsin was bleached at the beginning of dark adaptation.


Sustained and transient neurones in the cat's retina and lateral geniculate nucleus. 1. Cat retinal ganglion cells may be subdivided into sustained and transient response-types by the application of a battery of simple tests based on responses to standing contrast, fine grating patterns, size and speed of contrasting targets, and on the presence or absence of the periphery effect. The classification is equivalent to the ;X'/;Y' (linear/nonlinear) subdivision of Enroth-Cugell & Robson which is thus confirmed and extended.2. The sustained/transient classification applied to both on-centre and off-centre cells.3. Lateral geniculate neurones may be similarly classified by the same tests. Occasional concentrically organized cells had a mixture of sustained and transient properties.4. A technique for simultaneous recording from a geniculate neurone and one or more retinal ganglion cells providing its excitatory input showed that the connexions were specific with respect to the sustained/transient classification as well as the on-centre/off-centre classification. Most geniculate neurones are excitatorily driven only by retinal ganglion cells of the same functional type. In a few cases the inputs were mixed but only with respect to the sustained/transient classification.5. Sustained retinal ganglion cells had slower-conducting axons than the transient type. The same was true for lateral geniculate neurones but in this case the distributions showed considerable overlap.6. The sustained/transient classification is the functional correlate for the well-known segregation of optic nerve fibres into two conduction groups.7. The pathways carrying sustained and transient information remain essentially separate from retina through the lateral geniculate nucleus to the striate cortex.


Cytogenetic evidence for materno-fetal transfusion of polymorphonuclears.


Nutritional status of low income pregnant teen-agers.


The effect of dietary lipids and alpha-tocopherol on RES activity in choline deficiency. Res and fatty livers.


Carbohydrate metabolism in the human platelet.


Lymphocyte--lymphocyte interactions in normai bovine thoracic duct lymph.


Interaction of mast cells and macrophages in vitro.


Effect of beta-3-thienylalanine on antibody synthesis. VI. Ultrastructural changes in spleen cells of immunized rats.


The effect of 'aging' of an inhibitor of spontaneous tumors in mice. II. Observations at aging from 101-1346 days.


Acute intestinal ischemia shock and reticuloendothelial system function.


Adenocarcinoma and transitional cell carcinoma occurring simultaneously in the urinary bladder (mixed tumor).


Cost effectiveness in the post-treatment follow-up of cancer patients.


Pitfalls in the diagnosis of metastatic carcinoma.


Pattern of lymphatic spread in pharyngeal cancer.


Cancer of the tongue in young persons.

Cancer of the tongue in young persons.


Psychological considerations in the attainment of esophageal speech.


The stimulation and inhibition of the growth capacities of spontaneous tumors of mammary gland origin in mice (adenocarcinomata).


Combination of chemotherapy with dual antagonists and radiotherapy in the treatment of neoplastic disease.


Glucose intolerance in hepatic schistosomiasis.


Epidemiology of rheumatic heart disease in Iran. Observations on 10,676 Iranian school children.


Methodology of experiments on the perception of synthesized vowels.


Curriculum development in the medical schools.


Acute bronchiolitis following provocative inhalation of "alcalase"--a proteolytic enzyme used in the detergent industry.


Perception of electronically gated speech.


Transferable multiple antibiotic resistance amongst shigella strains isolated in melbourne between 1952 and 1968.


Popliteal cysts and their rupture in the rheumatoid arthritis simulating thrombophlebitis.


Appendicectomy: a personal series with no mortality and low morbidity.


Fifty consecutive cases of circumcision with the "plastibell" circumcision device.


Racial differences in associative style.


An effect of one German-language course on English.


Synthetic vowel categorization and dialectology.


The febrile response in the aged.

The febrile response in the aged.


Dilemmas facing curriculum framers.

Dilemmas facing curriculum framers.


Sound symbolism in words relating to proximity and distance.


A new medical education and training programme based on five years of undergraduate study and two years of graduate study.


New medical course in Adelaide.

New medical course in Adelaide.


Effects of context, intonation and voice on the reaction time to sentences.


Vocabulary and pronunciation acquisition among bilinguals and monolinguals.


The syntactic location of hesitation pauses.


Undergraduate medical education six years or five?


The undergraduate curriculum in medicine. A criticism of current trends.


Phenylketonuria: a multidisciplinary approach to management.


Recurrence risk of mental retardation in sibs.


Haemoglobin Norfolk: another example in Sydney.


The aqueous fluid and the iris.

The aqueous fluid and the iris.


Health care in Australia: an impending crisis.


The elderly in present-day society.

The elderly in present-day society.


Processing and recall of compatible and incompatible question and answer pairs.


National Health Service: referral of patients.


General practice.

General practice.


Monoglyceride hydrolase in adipose tissue of obese hyperglycemic mice.


Adipose tissue fat cell size and number in relation to metabolism in randomly selected middle-aged men and women.


Glucose kinetics and fatty acids in dogs on matched insulin infusion after glucose load.


Autosomal recessive inheritance of renal glycosuria.


Unified hypothesis for early biochemical sequence of events in steroid hormone action.


[Follow-up study of chronic nephritis: chronic nephritis with normal renal function and hypertension].


[Round table discussion: topics on neuromuscular disease].


Polymethylmethacrylate in hip reconstruction.


Medicine in Yugoslavia--a student's view.


Herpes simplex infection of the central nervous system. Survival without IUDR therapy.


Drug therapy. 13. Adverse drug reactions.


Relative invluence of diet and genotype on fat deposition.


The mentally handicapped--a survey of current services.


The role of the physiotherapist in the special training school.


Forces and directions in the future of plastic surgery.


The assessment and care of the deaf-blind child.


Reduction mammaplasty by the Dufourmentel-Mouly method.


Alternate case study of topical sulfamylon and silver sulfadiazine in burns.


Improved technique for one-stage repair of bilateral cleft lip.


Temporal muscle transfers to the incompetent soft palate. A progress report.


An internal wire splint for adduction contracture of the thumb.


Eye socket reconstruction with composite grafts.


Performance of cosmetic surgery by plastic surgical residents in city hospitals.


Total reconstruction of the ear in congenital microtia.


Elephantiasis of female genitalia. Case peport.


Cervical esophageal reconstruction after a laryngectomy and subtotal esophagectomy. Case report.


A simple and inexpensive dermabrader.

A simple and inexpensive dermabrader.


A new method for permanent preservation of anatomical specimens.


A new bipolar forceps for electrocoagulation.


Renal function in Bos taurus and Bos indicus-crossbred cows under conditions of normal hydration and mild dehydration.


Experimental erysipelothrix arthritis. II. Observations on rabbits following systemic administration of live E. rhusiopathiae or an intra-articular injection of non-living substances including inactivated organisms.


A low molecular weight protein in bovine serum with similar electrophoretic mobility to IgG 2 .


Milk-ejection activity in goat plasma during parturition.


Erythrocyte and leukocyte parameters in newborn lambs.


Vaso-active drugs and the occurrence of intra-muscular ecchymotic haemorrhages in the electrically stunned rat.


Establishment of a limited rumen microflora in gnotobiotic lambs.


Deep freeze preservation of nematode larvae.


Estimating erythrocyte 6-phosphogluconate dehydrogenase by a new method.


A method for obtaining cerebrospinal fluid from mice.


The isolation and characterization of a herpesvirus from calf kidney cell cultures.


Glomerulonephritis in a dog. A histological and electron microscopical study.


The anthelmintic activity of nitroxynil (4-hydroxy-3-iodo-5-nitrobenzonitrile) against parasitic nematodes in ruminants.


Ecologic illness. Investigation by provocative tests with foods and chemicals 1963-1970.


Bacterial endocarditis on a prosthetic aortic valve.


Doctor. When should you retire?

Doctor. When should you retire?


How smoking causes lung cancer.

How smoking causes lung cancer.


Rubella vaccination in the puerperium.

Rubella vaccination in the puerperium.


Dupuytren's contracture. Analysis of 100 consecutive surgical cases.


Anticoagulants in acute coronary disease. Relapse after termination of therapy.


Lupus erythematosus--multiple hematologic abnormalities.


General hospital services of the Colorado State Hospital.


Scanning in cerebral vascular disease.

Scanning in cerebral vascular disease.


Scanning in diseases of the subdural space.


Value of the vertex view in brain scanning.


The importance of brain scanning to the neurologist and neurosurgeon.


Intravenous and intracarotid radionuclide cerebral angiography.


Differentiation of brain and bone tumors with combined radionuclide technique.


Radionuclide cisternography.

Radionuclide cisternography.


Problems in the diagnosis and management of pulmonary embolism.


Role of the scan in bronchogenic carcinoma.


The scintillation camera with diverging collimator: physical parameters and a clinical evaluation.


Camera studies of lung ventilation and perfusion.


Fluorodensimetric evaluation of regional ventilation in chronic obstructive pulmonary disease.


Temporal lobe dysrhythmia and impulsive or suicidal behavior: preliminary report.


Otologic problems in submucous cleft palate.


Amniography.

Amniography.


Facial fractures in small children.

Facial fractures in small children.


The computer as a tool in clinical medicine.


Serum ionized calcium: some factors influencing its level.


Psychoses in the general hospital.

Psychoses in the general hospital.


Barium-burger roentgen study for unrecognized, clinically significant, gastric retention.


Treatment of procidentia of the rectum.

Treatment of procidentia of the rectum.


Cavernous sinus thrombosis and orbital cellulitis.


Treatment of psoriasis by hydroxyurea.

Treatment of psoriasis by hydroxyurea.


Training for special education.

Training for special education.


Differences in educational needs.

Differences in educational needs.


Renovascular hypertension in pregnancy.

Renovascular hypertension in pregnancy.


Terry: a problem and two answers.

Terry: a problem and two answers.


Asthma and the School child.

Asthma and the School child.


Policyholder mortality declines.

Policyholder mortality declines.


Tuberculosis mortality in the United States, Canada, and Western Europe.


Detecting disease by biochemistry of blood.


Development of a vocational adjustment rating scale for the mentally retarded.


Memory and learning.

Memory and learning.


Modification of hyperactive behavior of a brain-damaged, emotionally disturbed child.


Attitudes towards a photograph of a mildly and severely mentally retarded child.


Motor skill development in the profoundly retarded.


Bilateral coccidioidal choroiditis. A clinicopathologic case report.


Juvenile sex-linked retinoschisis: clinical and genetic studies.


Von Hippel's angiomatosis retinae and pheochromocytoma.


Acute scleral necrosis: a hitherto unrecognized complication of retinal detachment surgery.


Electron microscope autoradiographic studies on the effect of chloroquine on the uptake of nucleosides by Plasmodium berghei.


Surface wrinkling retinopathy in eyes enucleated at autopsy.


A physico-chemical explanation for the clumping of malaria pigment by chloroquine.


Slowly progressive ischemic optic neuropathy. A clinicopathologic case report.


Trypanosoma musculi infection in intact and thymectomized CBA mice.


Basic concepts of color vision.

Basic concepts of color vision.


Morphology of Trypanosoma brucei in chick embryos.


The computer's impact in education.

The computer's impact in education.


DNA of stercorarian trypanosomes.

DNA of stercorarian trypanosomes.


Intracellular development in vitro of Trypanosoma dionisii of bats.


The problem of the medical record.

The problem of the medical record.


The size range of Balantidium coli.

The size range of Balantidium coli.


The attitude of the Joint Commission toward computerized medical records.


Symposium: color vision. Introduction.

Symposium: color vision. Introduction.


Cultivation of a pleomorphic variant of Trypanosoma (Trypanozoon) evansi and its transmission by Glossina morsitans.


The American physician's responsibility.


Listing of audiometers.

Listing of audiometers.


Endogenous development of the coccidian parasite Toxoplasma gondii.


The outer membrane of Schistosoma mansoni.


Symposium: computer assistance in health service. Summary.


Office cryotherapy for oral leukoplakia.


The ultrastructure of the cuticle of some filarial worms.


The transmission of immunity against Trichinella spiralis from mother to filial mice.


Mesenteric abscess caused by threadworm infection.


Flagellar adhesion in Crithidia fasciculata.


An epidemiologic study of presumed ocular histoplasmosis.


A simple electrical method for containing cockroaches.


A novel apparatus for determining odour-preference in head lice.


The McArthur microscope--open university model.


The distribution of Toxocara larvae in the central nervous system of the mouse.


Epidemiology of tropical nutritional neuropathy in Nigerians.


Haemoglobin A 2  in malaria patients.

Haemoglobin A 2  in malaria patients.


A study of poliovirus antibody level in Accra.


Comparison of a counting chamber and thick smear methods of counting microfilariae.


A note on the prevalence of umbilical hernia in South African preschool children.


Sickle cell anaemia in Zambia.

Sickle cell anaemia in Zambia.


Concurrent infection of white mice with T. cruzi and S. mansoni.


Strongyloides stercoralis infection presenting as necrotizing jejunitis.


A drop method for the Sabin-Feldman dye test using rodent serum as a source of accessory factor.


Use of sentinel animals in epidemiological studies of cutaneous leishmaniasis.


Chloroquine in amoebic dysentery.

Chloroquine in amoebic dysentery.


Ascaris in the lacrimal duct.

Ascaris in the lacrimal duct.


Oculopharyngeal muscular dystrophy treated by inferior constrictor myotomy.


Carcinoma of the palatine arch. A review of 73 patients.


Complications of Rubella vaccine inoculation among 8,051 school children.


Drug interactions.

Drug interactions.


Community German measles testing.

Community German measles testing.


Women who want to be women.

Women who want to be women.


Student evaluation of medical preceptorships. University of Wisconsin Medical School.


A review of therapeutic abortions at a southern university hospital.


Clinical studies in sex pre-determination.


Cardiovascular findings in children with acute rheumatic fever and rheumatic heart disease.


Pingelap and Mokil Atolls: migration.

Pingelap and Mokil Atolls: migration.


Pingelap and mokil atolls: genealogy.

Pingelap and mokil atolls: genealogy.


Calculations for changes in sickle-cell trait rates.


Patterns of D chromosome involvement in human (DqDq) and (DqGq) Robertsonian rearrangements.


Dominant piebald trait (white forelock and leukoderma) with neurological impairment.


Autoradiography of terminal DNA replication of the G group autosomes of man: homologue asynchrony of the later-replicating G pair.


Multiple abnormalities due to possible genetic inactivation in an X-autosome translocation.


Genetic variation of soluble glutamic-oxaloacetic transaminase in man.


Human salivary amylase: genetics of electrophoretic variants.


Quantitation and adaptation of gas chromatography to clinical blood gas analysis.


Simultaneous determination of carbon dioxide and chloride by the autoanalyzer.


A new look at the blood platelet.

A new look at the blood platelet.


Determination of human serum alkaline phosphatase by semi-solid state fluorimetric analysis.


Upper extremity bracing of the severely athetoid mental retardate.


Treatment in Taiwan.

Treatment in Taiwan.


Differences in electrical activity of the biceps brachii and brachioradialis muscles performing isometriclike supination and pronation exercises.


Territorial imperatives and the boundaries of professional practice in rehabilitation.


The occupational therapist as a school consultant for perceptual-motor programming.


You've got to know the territory: on territoriality and professional boundaries.


Upper extremity functional bracing: a follow-up study.


Haptic perception in preschool children. II. Object manipulation.


Follow-up study of wrist-driven flexor-hinge-splint use.


Nursing, medicine, and occupational therapy.


Psychology, social work, and medicine.

Psychology, social work, and medicine.


Organization concepts. II. Communication.


Medicine, nursing, and physical therapy.


Bilateral upper extremity valet.

Bilateral upper extremity valet.


Occupational therapy, nursing, and physical therapy.


Physical therapy, medicine, and occupational therapy.


A summary: on the delineation of boundaries of professional practice in rehabilitation.


Hyperbaric treatment of pressure sores.

Hyperbaric treatment of pressure sores.


Computerized unit for a cardiac rehabilitation program.


Psychologic effect of acute physical activity.


Peripheral neuropathy in acute intermittent porphyrias.


Words.

Words.


A proportionally controlled externally powered hand splint.


Anaesthesia for caesarean section.

Anaesthesia for caesarean section.


Effects of osmotic diuretics on C.S.F. pressure.


Depressed lymphocyte function in carcinoma of the breast.


Vagotomy for gastric ulcer combined with duodenal ulcer.


Human breast carcinoma culture: the effects of hormones.


Should the gastric antrum be vagally denervated if it is well drained and in the acid stream?


Prognosis after ileal resection for Crohn's disease.


Surgical techniques in giant goitres.

Surgical techniques in giant goitres.


The incidence and pathogenesis of tracheal injury following tracheostomy with cuffed tube and assisted ventilation. Analysis of a 3-year prospective study.


The intestinal response to surgery. The effect of operation upon the intestinal handling of water and electrolytes.


The handling of water and electrolytes by the small bowel following the relief of intestinal obstruction.


Prediction of success of failure of gastric surgery.


Use of a computer in duodenal ulcer surgery.


The delayed insulin test and recurrent duodenal ulceration.


On-line computing in surgery.

On-line computing in surgery.


The value of radiotherapy in the management of squamous oesophageal cancer.


Cancer of the stomach and oesophagus. Data concerning management and results.


Doctor in the lab.

Doctor in the lab.


The solitary thyroid nodule.

The solitary thyroid nodule.


Bronchial mucocoele.

Bronchial mucocoele.


Accidents at work.

Accidents at work.


Verdict on CS.

Verdict on CS.


New studies of strokes.

New studies of strokes.


Drugs for Ceylon.

Drugs for Ceylon.


On the risk of multiple sclerosis according to age at immigration to South Africa. In a national prevalence study of multiple sclerosis (M.S.) in the Republic of South Africa based on census day 1960 there were 118 individuals with M.S. who were born in Northern Europe (United Kingdom and other parts of North and Central Europe) and who had emigrated to the Republic by 1960. Their prevalence rate was 49 per 100,000 immigrants in comparison with a prevalence of 11 per 100,000 among native-born English-speaking white South Africans.To study the possible effect of age at immigration it was necessary to relate the M.S. immigrants to the appropriate denominator-the population at risk according to age at immigration. The population at risk by age at immigration has been estimated by two methods in an indirect fashion with the assistance of the Bureau of Census (1960) and by surveys of the population at risk 1968-9. Both studies suggest that the risk of developing M.S. was reduced to less than a third of the expected risk among those who immigrated under the age of 15 or 16.This study is further evidence that M.S. is an acquired exogenous disease, the precise nature of which is still not certain but, according to present knowledge, has as its leading contender the class of slow, latent, or temperate viruses.


Relationship between leucocyte and plasma ascorbic acid concentrations. Leucocyte and plasma ascorbic acid values were measured in healthy students, adult factory employees, and old people not receiving supplementary vitamin C and in healthy old people receiving 500 mg of vitamin C daily. Significant positive correlations between leucocyte and plasma ascorbic acid were found in all the groups. The regression lines differed significantly between one another within the sexes, but the pooled lines for each sex did not differ significantly in the unsupplemented groups. The relationship between plasma and leucocyte ascorbic acid values in the supplemented group differed significantly from that in the pooled unsupplemented groups.There was a limited range of variation in leucocyte ascorbic acid values compared with the range in plasma values in the supplemented group, whereas there was a wider range of variation in the leucocyte values in the unsupplemented groups. Leucocytes can therefore achieve a saturation level of ascorbic acid. Measurement of leucocyte ascorbic acid concentrations alone does not provide a reliable guide for the estimation of tissue status of ascorbic acid in normal individuals. Leucocyte concentrations provide a measure of the availability of ascorbic acid for storage, and plasma levels give an indication of its metabolic turnover rate. When these values are related the regression lines provide information about the storage and metabolism of ascorbic acid in normal individuals.


Fatal complications of central venous catheters.


Epidemic listeriosis in the newborn.

Epidemic listeriosis in the newborn. Within a three-month period 13 cases of listeriosis in the newborn were seen at the National Women's Hospital, Auckland. Eleven presented in the first 24 hours of life, the most common feature being respiratory difficulty in low birth weight infants. Meconium-stained liquor was noted in nine cases. The constant finding in all cases was an aspiration pneumonia which appeared to be of intrauterine origin from an infected amniotic cavity. There was also evidence of septicaemia in nine cases, and two infants survived meningitis which developed at 1 week. Maternal symptoms were mild and variable, and in only one case were they proved to be due to listerial infection. The mothers came from different suburbs of Auckland and no common source of infection was found.


Pharmaceuticals management in Ceylon.

Pharmaceuticals management in Ceylon.


New test for the detection of peripheral arteriovenous fistulae.


Removal of corneal foreign bodies by disposable needle.


Prevention of accidents.

Prevention of accidents.


Disposing of the undisposable.

Disposing of the undisposable.


Addiction or dependence?

Addiction or dependence?


Evidence to the coroner.

Evidence to the coroner.


Fibrin/fibrinogen degradation products in glomerulonephritis.


Arteriosclerosis, duodenal ulcer, blood group, and secretor status.


Dermatoglyphics and chromosomes in cat-eye syndrome.


An XYY individual of average height.

An XYY individual of average height.


Flatulence.

Flatulence.


Survival in severe congenital heart disease.


Abortion or contraception?

Abortion or contraception?


Destruction of case records.

Destruction of case records.


Sauce, spices, and the kidney.

Sauce, spices, and the kidney.


"Clinical" and "administrative" pharmacists.


Cremation regulations.

Cremation regulations.


Periodic haemorrhages in haemophilia A.

Periodic haemorrhages in haemophilia A.


Air embolism during hemodialysis.

Air embolism during hemodialysis.


Air embolism during hemodialysis. 2.

Air embolism during hemodialysis. 2.


On the occurrence of hitherto unknown proteins in the urine of an apparently healthy subject.


Excretion of L-carnitine in man.

Excretion of L-carnitine in man.


Biochemical studies of the placental alkaline phosphatase.


The measurement of non-esterified fatty acids in icteric body fluids.


Factors affecting serum creatine phosphokinase levels in the general population: the role of race, activity and age.


Influence of plasma preparation technique on the amount of recovered B 12 -binding proteins.


Collagen reutilization in normal and hypersomatotrophic rats.


Studies on the uptake of (I- 14 C)ascorbic acid and (I- 14 C)-dehydroascorbic acid by platelets of guinea pigs.


The validation of biochemical assays by recovery data with special reference to serum iron.


Some characteristics of trichloroacetic acid-precipitated proteins and their effects on biochemical assay.


Urinary excretion of testosterone and epitestosterone in men, women and children, in health and disease.


-N-acetylglycyl-lysine methylesterhydrolase and plasminogen activator in urine. Method of determination and some considerations.


Diagnostic value of electrophoretical isoenzyme determination of L-lactate dehydrogenase in affected quadriceps muscle of patients with neuromuscular diseases.


Influence of non-protein nitrogen substances on the indophenol reaction.


Serum gamma-glutamyl transpeptidase in muscle disease.


Isomaltose and maltose in the urine of severely injured humans.


Improved method for the determination of iodine in urine.


Separation and identification of barbiturates and glutethimide by thin-layer chromatography.


Automatic determination of ornithine carbamyltransferase.


The determination of ethosuximide in serum by gas chromatography. Preliminary results of clinical application.


Prealbumin proteins in serum.

Prealbumin proteins in serum.


In vivo incorporation of dietary ( 14 C)cholesterol in rat serum lipoproteins and transfers in connective tissue.


Sex-chromosome mosaicism in pouch young of marsupials Perameles and Isoodon.


Chromosome abnormalities in 16- to 18-hour chick embryos.


Cytogenetic analyses of wild sheep populations in northern Iran.


Multiple screening.

Multiple screening.


Manpower and the National Health Service.


The idiogram of the Venezuelan vole mouse, Akodon urichi venezuelensis Allen (Rodentia, Cricetidae).


Record linkage and the community.

Record linkage and the community.


The Brighton Project as seen from the university.


A community-based medical computing system.


Pigs feed us.

Pigs feed us.


More sinned against than sinning. An introduction to new systems in medical care.


The Brighton Project as seen from general practice.


Three major deficiencies: a critical look at medicine.


Association of pulmonary sequestration and duplication of the stomach.


Phlegmasia cerulea dolens.

Phlegmasia cerulea dolens.


Tubal ligation through the posterior fornix with the aid of the culdoscope.


Surgical treatment of peptic ulcer.

Surgical treatment of peptic ulcer.


Genital prolapse in pregnancy and labor.


Obstetric consequences of amputation of the uterine cervix.


Volume backscattering in the South China Sea and the Indian Ocean.


Effect of phagocytosis on membrane transport of nonelectrolytes. The activities of specific transport systems were determined before and after large portions of the surface membrane had been interiorized by phagocytosis of inert particles. In five separate transport systems in rabbit polymorphonuclear leukocytes (adenosine and two adenine transport systems) and alveolar macrophages (adenosine and lysine transport systems), the rate of transport was unaffected even after an estimated 35-50% of the membrane had been internalized. Studies of the kinetics of lysine and adenosine transport, exchange diffusion of lysine transport in alveolar macrophages, and the specificities of adenine transport in polymorphonuclear leukocytes indicate that the nature of the membrane transport systems is not altered by phagocytosis. Therefore the constancy of transport indicates that the number of carriers remains the same before and after phagocytosis. It was also shown that this constancy of transport did not depend on the introduction into the surface of new transport sites during phagocytosis. Therefore transport sites are preserved on the surface during the internalization of membrane which accompanies phagocytosis. The results are best explained by the concept that the membrane is mosaic in character with geographically separate transport and phagocytic sites.


Disengagement among professors.

Disengagement among professors.


The development of hypersensitive lymphocytes in cell culture. An in vitro cell-mediated immune response to pokeweed mitogen (PWM) is described. Rat lymphocytes were stimulated by PWM, by phytohemagglutinin (PHA), and by concanavalin A (ConA). In the presence of PWM only a fraction of the lymphocytes underwent blastogenesis. This was in contrast to the apparent total blastogenesis obtained in response to PHA or ConA. When blast cells derived from each of the mitogens were plated on rat fibroblast monolayer in the absence of mitogen they differentiated into a distinct type of lymphocyte termed "secondary lymphocyte." Addition of mitogens to cultures of these lymphocytes resulted in a retransformation to blast cells. The secondary lymphocytes were tested for their ability to effect lysis in the presence of each of the three mitogens. In. the presence of PWM, lysis of fibroblasts produced by PWM-lymphocytes was considerably more efficient than lysis obtained by ConA- or PHA-lymphocytes. No difference in effect on target fibroblasts was obtained when the three types of secondary lymphocytes were tested in the presence of either PHA or ConA. The stimulating action of PWM on lymphocytes was shown to be immunologically specific. No such specificity was found in the case of PHA or ConA. The results are interpreted to indicate that PWM combines with cell membranes and acts on the lymphocytes as a "transplantation antigen." Lymphocytes capable of responding to "PWM-transplantation antigen" transform to blast cells capable of specifically lysing PWM-conjugated fibroblasts. In the absence of the mitogen, PWM-induced blast cells differentiate to lymphocytes hypersensitive to PWM.


Free radical theory of aging: effect of the amount and degree of unsaturation of dietary fat on mortality rate.


Serum tocopherol levels and vibratory threshold changes with age.


The effect of egg laying on the longevity of the adult female house fly, Musca domestica, L.


The impact of relocation upon mortality rates of institutionalized aged persons.


Calcium metabolism in aging mice.

Calcium metabolism in aging mice.


Metabolism of hyaluronic acid in the skin of aging mice.


Protein metabolism in aging mice.

Protein metabolism in aging mice.


Asphyxiating thoracic chondrodystrophy. Association with renal disease and evidence for possile heterozygous expression.


Concordance for amyotrophic lateral sclerosis in a pair of dizygous twins of consanguineous parents.


Presumptive 46,XX-46,XY-47,XXY mosaicism in a hermaphrodite.


Trisomy of chromosome 16 in a neonate, 47XY,?16+.


Phenylketonuria.

Phenylketonuria.


An inherited kidney disease of mice resembling human nephronophthisis.


Chromosome surveys in penal institutions and approved schools.


Congenital cleft lip. A genetic study of 496 propositi.


Familial incidence of cerebrovascular disease.


Genetic-epidemiological studies in progressive muscular dystrophy.


The Smith-Lemli-Opitz syndrome in a profoundly retarded epileptic boy.


Methodological problems with ecological variables.


Gene deletion and duplication effects on phenotype and gamma globulin levels.


Pathological observations on a male patient with D-ring chromosome.


Rectification in instantaneous potassium current-voltage relations in Myxicola giant axons. 1. Measurements of the instantaneous K current, under voltage clamp, were obtained using paired de- and hyperpolarizing clamp pulse sequences. The instantaneous potassium current-voltage relations so obtained showed constant field type rectification.2. The zero current potential of the instantaneous K current-voltage relation, when examined as a function of the K concentration, [K](o), behaved like a Nernst concentration cell potential for K. It was concluded that during the generation of the delayed current, the membrane shows substantial selectivity for K.3. The equivalent of the ;Frankenhaeuser-Hodgkin space' in Myxicola was found to be more difficult to load with K ions than in squid. The thickness of the space may be taken as effectively about seven times larger than in squid.4. Myxicola axons were found to show little or no long time constant delayed current inactivation as has been described for squid.5. In high [K](o) a negative steady-state conductance was observed which was predictable from the independence principle with a suitable scaling factor.


Catecholamine synthesis and excretion in rats exposed intermittently to cold. Previous findings have shown a turnover of nuclear DNA, a condition related to the functional activity of these cells, in the adrenal medullae of rats intermittently exposed to cold. Striking differences have been observed between various strains of rats, particularly Italico and Wistar rats. In order to evaluate the function of the adrenal medullary cells, the content of catecholamines in the organ and their urinary excretion have been evaluated, with the fluorimetric method, in rats of Italico and Wistar strains kept at room temperature and exposed intermittently to cold. The results show that (i) at room temperature the levels of excretion are lower in Italico than in Wistar rats in spite of the equal amine contents of the adrenal medullae, (ii) the first exposure to cold causes a large increase in the urinary excretion and a decrease of adrenaline and noradrenaline content of the adrenal glands in both strains, (iii) after 3 days the catecholamine content in the organ was higher than normal in Wistar rats, whereas in the Italico strain it continued to decrease, and (iv) a new steady state at higher levels is reached after 20 days of exposure, when not only the catecholamine content but also the urinary excretion is equal in both strains. These differences between the two strains of rats during intermittent cold exposure are discussed in relation to the behaviour of DNA.


Fever produced by prostaglandin E1.

Fever produced by prostaglandin E1. Prostaglandin E(1) (PGE(1)) produces a rise in rectal temperature when injected into the cerebral ventricles of unanaesthetized cats, rabbits and rats. An effect is obtained with as little as 20, and sometimes even with 10 ng.


Methyl histamines and gastric secretion. 1. The previous findings that N-methylhistamine and N-dimethylhistamine are more potent stimulators of gastric secretion than histamine have been confirmed in dogs with Heidenhain pouches or gastric fistulas.2. In cats with gastric fistulas, doses of N-methylhistamine of 0.25 or 0.5 mumole/hr produced 1.4-1.6 times as much HCl as equimolar doses of histamine.3. The maximal HCl outputs of dogs with Heidenhain pouches to histamine, N-methylhistamine, and N-dimethylhistamine were not significantly different, though lesser doses of the N-methyl derivatives were required to produce the maxima. At the one-half maximal level, N-dimethylhistamine showed a twofold greater potency than histamine.4. When given slowly or quickly via arteries supplying blood to the stomach of dogs or cats with gastric fistulas or via the artery to a Heidenhain pouch in a dog, 0.1-1.0 mumole N-methylhistamine or N-dimethylhistamine produced 4.1-13.9 times as much HCl as equimolar doses of histamine.5. Injection of histamine or N-methylhistamine via the portal vein in two dogs with gastric pouches stimulated less secretion of HCl than injection of the same doses via a systemic vein.6. The results allow the conclusion that N-methylhistamine and N-dimethylhistamine are more potent stimulators of acid gastric secretion than histamine in dogs and cats, particularly when delivered directly via the arterial route to the gastric mucosa, and support the prospect that N-methylhistamine or N-dimethylhistamine or both are natural chemostimulators of the parietal cells.


Daily changes in amniotic and allantoic fluid during the last three months of pregnancy in conscious, unstressed ewes, with catheters in their foetal fluid sacs. 1. Catheters were inserted into the maternal and foetal vasculatures of ten ewes, 100-139 days pregnant, and daily samples of uterine and umbilical blood and maternal jugular vein blood were taken for periods of 5-27 days after operation.2. Catheters were inserted into the fluid sacs of nineteen foetuses, 60-97 days post-conception, and daily samples were withdrawn for up to 90 days from amniotic sacs (eleven foetuses) and for up to 70 days from allantoic sacs (eight foetuses). Maternal jugular plasma was obtained 3 times weekly and an approximation from its composition to that of uterine and umbilical plasma was made using results from the ewes and foetuses with vascular catheters.3. The pH, osmolality, [Na(+)], [K(+)], [Cl(-)], [urea] and [amino acid] of all samples were measured.4. The nutritional status of all ewes was monitored throughout pregnancy. Most lambs were born naturally at approximately 147 days post-conception and their subsequent progress was observed.5. Results at operation and from acute experiments were compared with those from conscious ewes and foetuses of the same gestational age to assess the nature and extent of the influence of the operative procedures on foetal fluid composition. The composition of amniotic fluid was influenced mainly by the anaesthetic and surgical procedures while that of allantoic fluid was affected largely by starvation of the ewe.6. Changes during recovery from operation were followed and indicated that maternal and foetal plasma required about 3 days and the foetal fluids up to 7 days before stability of composition was achieved.7. After recovery from operation, daily changes in the composition of each foetal fluid showed the same general pattern in all foetuses, but the absolute values of constituents sometimes showed large differences.8. It is suggested that flow of foetal urine into the amniotic sac increased from 80 days gestational age, that urine flow into the allantoic sac decreased until about 100 days but did not cease thereafter, and that relative to foetal urine the influence of foetal pulmonary fluid on amniotic fluid composition was not great.9. A relative impermeability of the amnion appeared to be a major factor influencing amniotic fluid composition, whereas pumping mechanisms in the chorioallantois seem to have been responsible largely for changes in the composition of allantoic fluid.10. The quantity of solute relative to that of water within each sac appears to be a major determinant of changes in foetal fluid volumes.11. Changes in the [Na(+)] and [K(+)] of allantoic fluid during the normal course of pregnancy were consistent with an increasing action of mineralo-corticoids on pumping mechanisms in the chorioallantois. Similar but more rapid changes seemed to be associated with acute and chronic episodes of maternal hypoglycaemia. Under these circumstances foetal hypoglycaemia may effect a relative increase in the secretion of foetal corticosteroids having an action on the chorioallantois.12. The results from this study demonstrate clearly the value of using chronically catheterized animals, and it is suggested that their use in physiological studies on the conceptus must eventually supersede that of acute, anaesthetized preparations.


Storage of ATP and 5-hydroxytryptamine in blood platelets of guinea-pigs. 1. By density gradient centrifugation of homogenized blood platelets of guinea-pigs, subcellular organelles have been isolated which exhibit much higher concentrations (mumole/mug protein) of ATP than the whole platelets.2. The organelles also store endogenous 5-HT whose concentration is, however, considerably inferior to that of ATP.3. Investigated by electron microscopy most of the isolated organelles look empty and only very few show dense osmiophilic cores indicating the presence of 5-HT. Accordingly the occurrence of dense osmiophilic organelles in the whole platelets is also very rare.4. Exogenous 5-HT taken up by the platelets markedly accumulates in the subcellular fraction containing the organelles storing ATP. Concomitantly, the platelets show a rise in the number of osmiophilic organelles and the frequency of osmiophilic cores in the isolated organelles is increased.5. From these and previous in vitro experiments it is concluded that the so called 5-HT storage organelles of blood platelets primarily store ATP and only subsequently accumulate 5-HT.


The resting membrane potential of the somatic muscle cells of Ascaris lumbricoides. 1. The resting membrane potential of Ascaris muscle fibres, which is normally relatively insensitive to ion changes in the medium, has been measured under a wide variety of conditions.2. The results have been interpreted in terms of a form of the constant field equation containing additional terms for the contribution of ions and charged groups other than potassium, sodium and chloride.3. Normally the contribution of the additional terms is large and tends to outweigh the contributions of potassium, sodium and chloride.4. The contribution of the additional terms is considerably reduced in the absence of sodium and in the presence of gamma-amino butyric acid and acetylcholine.5. It is suggested that the additional terms may represent the contribution of an electrogenic active transport mechanism to the factors determining the membrane potential.


The mechanics of sprint running.

The mechanics of sprint running. 1. The effect of the velocity of shortening on the power developed by the muscles in sprint running was studied by measuring the mechanical work done to accelerate the body forward from the start to about 34 km/hr.2. The work was measured at each step from the data obtained by means of a platform sensitive to the force impressed by the foot.3. Almost the totality of the positive work done during the first second from the start is found as an increase of the kinetic energy of the body. However, as the speed of the run rises, air resistance and particularly the deceleration of the body forward, taking place at each step, rapidly increase, limiting the speed of the run.4. The average power developed by the muscles during the push at each step increases with the velocity of running reaching 3-4 h.p. at the maximal speed attained.5. At low speed the contractile component of the muscles seems to be mainly responsible for the power output, whereas at high speed (25-34 km/hr) an appreciable fraction of the power appears to be sustained by the mechanical energy stored in the ;series elastic elements' during stretching the contracted muscles (negative work) and released immediately after in the positive work phase.


Effect of microcirculation changes on brain tissue oxygenation. 1. A new, 2 mu tip, oxygen micro-electrode and a constantly circulated Beckman oxygen gas analyser were used to measure tissue and blood P(O) (2) in anaesthetized, curarized cats under positive pressure breathing. As a parameter for the ability of the circulation to oxygenate tissue, the ;reoxygenation time' (defined as the time required to reach the previous P(O) (2) level after a short period of anoxic anoxia) was determined on blood and cerebral cortex.2. First, it was found that haemorrhage (from 15-25 c.c./kg) alone or haemorrhage combined with sludging of the blood (by the I.V. administration of high molecular weight Dextran, 1 g/kg) markedly diminished P(O) (2) levels in blood and tissue.3. Further, the reoxygenation time was significantly affected by these procedures. Sludging markedly prolonged the reoxygenation time, an effect counteracted by the use of an anti-adhesive drug breaking up the red cell aggregates.4. Bleeding prolonged the reoxygenation time up to four times that found in the same animals previous to the bleeding.


The form and distribution of the receptive fields of Pacinian corpuscles found in and around the cat's large foot pad. 1. Firing thresholds of Pacinian corpuscles situated within or close to the large pad of the cat's hind foot have been determined following step displacements applied to various points on the pad surface.2. The most sensitive positions on the receptive fields of thirty-one corpuscles were distributed unevenly over the pad. About half were situated close to the interlobular crease lines, and most of the others were at the edge of the pad.3. Threshold receptive fields were usually of complex form, with more than one region of low threshold.4. The approximate locations of a number of Pacinian corpuscles whose fields had been mapped were determined by dissection.5. The most sensitive position on the pad was usually at the closest point to the corpuscle. If the corpuscle was situated outside the pad itself, it was therefore usually most easily excited from some point at the edge of the pad. However, a minority of Pacinian corpuscles were most easily stimulated from some region other than that closest to them.6. It is suggested that previous estimates of the ability of this population of receptors to transmit information about the positions of stimuli (Gray, 1966) must be re-evaluated in the light of the non-uniform distribution and asymmetry of their cutaneous receptive fields.


Scanning electron microscopy of mammalian spermatozoa.


Dysplasia following podophyllin treatment of vulvar condyloma acuminata. A case report.


How the Kaiser-Permanente Medical Care Complex enhances medical care and education.


Does betterment follow innovations in hospital planning? A positive response with centralized surgery/obstetrics.


Emergency room vacuum curettage for incomplete abortion.


Cryocauterization for preinvasive cervical neoplasia.


Prevalence and incidence rates of cervical atypia. A computerized file analysis of 148,735 patients.


The study of fetal growth by serial cephalometry and estriol measurements.


Spontaneous rupture of the liver during pregnancy. Report of a case.


Proceedings of the Association of Professors of Gynecology and Obstetrics, New Orleans, Lousiana, March 2, 1971.


The role of the medical journal in undergraduate education.


In deense of the written word: the textbook.


The scope and potential of outpatient care in obstetrics and gynecology.


Intracranial complications of ear, nose, and throat infections.


The otological aspects of whiplash injuries.


Nasal septum: experimental and clinical correlation of surgery or injury.


Ketamine anesthesia in minor otologic procedures.


Autograft and homograft incus transpositions in chronic otitis media.


Sudden deafness and round window rupture.


Clues to the life history of carcinoma in situ of the larynx.


Delayed contralateral cervical metastases with laryngeal and laryngopharyngeal cancers.


Carcinoma of the hypopharynx--a study of distant metastases, treatment failures, and multiple primary cancers in 215 male patients.


Distant metastases from carcinoma of the larynx.


Comparative application of revised (1971 "T") classification, pathological findings, and five-year end results in surgically treated cancer of the larynx.


Epithelial papillomas--benign or malignant? Interesting findings in laryngeal papilloma.


Facial palsy caused by facial nerve tumor.


Three-dimensional uniform flow in an oxygenator.


The design of modern instrumentation for the measurement of gas expired from the lung.


A mathematical model of the electrocardiographic QT-RR relationship.


The measurement of intracranial echo pulsations.


Digital computer simulation of pulse wave transmission in arteries.


A-scan echo-encephalography at the cross-roads: art or science.


Computer analysis and simulation of human gastroduodenal electrical activity.


Statistical monitoring techniques.

Statistical monitoring techniques.


Multichannel storage spectrophotometer.

Multichannel storage spectrophotometer.


A new simple detector for Achilles reflex measurement.


Calibration of contact microphones applied to the human chest wall.


Power for artificial arms from normal walking.


A staircase signal-generator for telemetry standardization.


An instrument for measuring the vibration transmissibility of vehicle seats.


A 24-channel electrocardiographic preamplifier.


Total internal reflection light chamber.


A cooling device for the cold-blocking of nerves.


Phase calibration of a physiological motion detector.


EMG burst envelope detector.

EMG burst envelope detector.


Cardiomyopathy associated with heredofamilial neuromyopathic diseases.


Have nurses a part to play?

Have nurses a part to play?


Notes on the social and community services. Family planning.


Nursing care study: head-injury rehabilitation.


Is interviewing enough?

Is interviewing enough?


New clinical specialist--a growing breed.


Hiatus hernia in adults.

Hiatus hernia in adults.


Drugs and hypertension.

Drugs and hypertension.


'What hope can I have'?

'What hope can I have'?


Standards of care today.

Standards of care today.


Infant feeding in the maternity hospital.


Impaired spermatogenesis and tubular fibrosis in testes of New Guineans: a post-mortem study.


An Australian case of coccidioidomycosis?


Hydrencephaly in a baby after an aircraft accident to the mother: case report and autopsy.


A method for ultrastructural examination of tissue cultures.


Osteofluorosis in the rabbit: microradiographic studies.


Enzyme electrode probes.

Enzyme electrode probes.


Assessment of time of onset of parturition in goats by means of daily recording of rectal temperatures.


The Animals Act of 1971.

The Animals Act of 1971.


The site of replication of infectious bronchitis virus in the oviduct of experimentally infected hens.


Britain, Europe and the World.

Britain, Europe and the World.


Background to Europe.

Background to Europe.


Scientific contacts in Europe in the veterinary field.


The international Veterinary Students' Association and Europe.


Some aspects of small-animal practice in the E.E.C.


Acid responses to histamine, pentagastrin and human gastrin I in conscious cats with gastric fistulas and Heidenhain pouches.


Effect of anticholinergic agents on the intestinal absorption of  59 Fe ferrous citrate.


Bile-rich duodenal fluid as an indicator of biliary lipid composition and its applicability to detection of lithogenic bile.


Acute massive hepatic necrosis with fatal liver failure.


Lactose intolerance in Jewish patients with ulcerative colitis.


Effect of physiologic concentration of lactose on prevention of postweaning decline of intestinal lactase.


Colonic electrical activity recording and total fiberoptic colonoscopy. Two new applications of transintestinal intubation.


Adenocarcinoma occurring in Crohn's disease of the small intestine.


Hepatitis induced by methyldopa (aldomet). Report of a case and a review of the literature.


Cutaneous manifestations presenting prodromal symptoms of ulcerative colitis. Report of three cases.


The radiology corner. Ischemic colonic disease associated with carcinoma of the colon.


Status of duodenal ulcer patients ten years or more after vagotomy-pyloroplasty (V-P).


A new role for the pharmacist in the detection and evaluation of adverse drug reactions.


A role for the hospital pharmacist in toxicology and drug blood level information.


Statement on clinical pharmacy and its relationship to the hospital.


Physician reaction to a clinical pharmacist.


Computer concepts.

Computer concepts.


Selective gastric vagotomy with antrectomy or pyloroplasty.


Experience with a new technic of intestinal bypass in the treatment of morbid obesity.


Total hip replacement.

Total hip replacement.


Suboccipital transmeatal microneurosurgical resection of acoustic tumors.


A clinical investigation of the portacaval shunt. V. Survival analysis of the therapeutic operation.


Biliary tract disease in sickle cell anemia: surgical considerations.


Congenital cystic disease of the liver and biliary system.


Naphthylamidase in ameloblasts during enamel maturation.


Studies of the mechanism of biological calcification. II. Evidence for a multi-step mechanism of calcification by tendon matrix.


Ultrastructural observations on the inorganic-organic relationships in early cartilage calcification.


Dentin matrix collagen: evidence for a covalently linked phosphoprotein attachment.


Acute toxic effects of sodium selenate on the epiphyseal plate of the rat.


Species specificity of osteogenesis induced by WISH cell line and bone induction by vaccinia virus transformed human fibroblasts.


Community development--a world view.

Community development--a world view.


Medicare and the public health professional.


Nutritional status of British Columbia Indians. I. Dietary studies at Ahousat and Anaham reserves.


Control measures for physicians' fee payments under provincial health insurance schemes.


Mis-aid to the Third World: disease repercussions caused by ecological ignorance.


Stress, cigarette smoking and snacking behaviour in adolescent males.


A brucellosis survey in Isfahan, Iran.

A brucellosis survey in Isfahan, Iran.


Physician's substitute--the role of the nurse in the North.


Multiple Sclerosis Society of Canada.

Multiple Sclerosis Society of Canada.


Community health commentary. Northern seminar, 1971.


Nutrition in adolescence.

Nutrition in adolescence.


Public health nurses in Quebec and the Castonguay-Nepveu Report.


Ulcerative colitis in Finland. I. Cases treated at central hospitals, 1956-1967.


Traumatic injuries to the colon: a review of five years' experience.


Tuberculosis of the anal canal: report of a case.


Regional ileitis with free perforation into the peritoneal cavity twice: report of a case.


Ulcerative colitis in Finland. II. One-year incidence in all hospitals.


Loop colostomy. Bar versus rod.

Loop colostomy. Bar versus rod.


Quantitative characterization of unit response in the visual system.


Sequential change in receptive fields of striate neurons in dark adapted cats.


Quantitative variation in striate receptive fields of cats as a function of light and dark adaptation.


Role of the pia mater in the transfer of substances in and out of the cerebrospinal fluid.


Mortality of ageing people (males) by social groups in gainfully employed population in Bulgaria during 1965-1966.


On becoming an exdriver: prospect and retrospect.


Walking as a means of transportation for retired people.


Politics through the life cycle.

Politics through the life cycle.


Some political consequences of senior center and other old age group memberships.


Excess disabilities of mentally impaired aged: impact of individualized treatment.


Personality traits in the mentally-impaired aged and their relationship to improvements in current functioning.


Changes in hearing with age.

Changes in hearing with age.


Some problems in milieu treatment of the chronic older mental patient.


Social aging, disorganization, and loss of choice.


A social role analysis of senility.

A social role analysis of senility.


Special report on Ontario--the host province for the 1970 scientific meeting of Gerontological Society. The role of the Ontario government in the care of the aged.


Effect of lactulose on cerebral metabolism in patients with chronic portosystemic encephalopathy. Cerebral blood flow and cerebral metabolism were studied in six patients with moderately severe portosystemic encephalopathy before and after a 10-day course of lactulose. As a result of therapy there was a mean increase in cerebral oxygen utilization but no changes in either mean glucose consumption or in mean cerebral blood flow. It appears therefore that the abnormalities in cerebral metabolism that have been previously described in patients with hepatic encephalopathy can be improved by the oral administration of lactulose.


Influence of diet on flatus volume in human subjects. Ten flatulent but otherwise healthy subjects were studied while consuming two or three different diets. Flatus collections showed that a bean-containing, high crude-fibre diet produced more flatus (mean 49.4 ml/hr) than either a diet with a restricted crude-fibre content (mean 26.7 ml/hr) or a liquid chemically defined diet (mean 10.9 ml/hr). There was a close correlation between the crude-fibre content of the diet and the production of flatus. The results are consistent with the conclusion that flatus is not the result of swallowing air, but arises mainly from bacterial fermentation of indigestible carbohydrate, eg, cellulose, passing into the colon.


Further observations concerning the effects of hypophysectomy on the gastric mucosa of the rat. Hypophysectomy in rats markedly reduced the weight and surface area of the stomach as well as the volume (mass) of the gastric mucosa and the total parietal and total peptic cell populations. The parietal cell population was reduced by about 50%, and this effect was due entirely to the reduction that occurred in the total surface area of the stomach (50%); the average number of parietal cells per unit area, which reflects the number of parietal cells in the gastric glands, was not affected. The peptic cell population was reduced by about 90%, the factors responsible being a reduction in the average number of peptic cells per unit area (70%) as well as the reduction that occurred in the surface area of the stomach. The disproportionate effect of hypophysectomy on the cell populations was thus due to the reduction in the number of peptic cells per unit area; this effect implies that hypophysectomy had caused a reduction in the number of the peptic cells in the gastric glands.Whatever the mechanisms involved these results were due to a direct effect of pituitary deprivation on the stomach, since they could not be accounted for simply by the inhibition of somatic growth that follows hypophysectomy in rats. Thus the experiment included a group of sham hypophysectomized rats whose somatic growth was inhibited to the same extent as that of the hypophysectomized animals by deliberate underfeeding. While underfeeding reduced the surface area of the stomach (20%) and the total peptic cell population (25%), as well as exerting a marginal effect on the parietal cell population, these effects were much smaller in magnitude than those of hypophysectomy; moreover underfeeding did not affect the number of peptic cells in the gastric glands. The results confirm that the pituitary gland exerts a strong influence on the growth of the gastricmucosa.


A comparison between spectrophotometric and titrimetric methods of estimating trypsin. The spectrophotometric method described is quick and effective and a reliable alternative to a titrimetric method for measuring trypsin activity in duodenal juice.


Sensory evaluation after median nerve repair.


An extension to an operating table for hand surgery.


A useful hand table.

A useful hand table.


Gripping surfaces for artificial hands.

Gripping surfaces for artificial hands.


The future of powered hand prostheses.

The future of powered hand prostheses.


Ulnar deviation splints.

Ulnar deviation splints.


De Quervain's disease--a clinical review.


The hand in quadriplegia.

The hand in quadriplegia.


Enzymic fasciotomy.

Enzymic fasciotomy.


The synovial structures of the normal and rheumatoid digital joints.


The zig-zag deformity in the rheumatoid hand.


Trigger finger syndrome in rheumatoid arthritis not caused by flexor tendon nodules.


The relationship of wrist motion to ulnar phalangeal drift in the rheumatoid patient.


Editorial: the British Society for Surgery of the hand.


Some new thoughts on hand prostheses.

Some new thoughts on hand prostheses.


Carpal tunnel syndrome in pregnancy.

Carpal tunnel syndrome in pregnancy.


Minimum number of proteases occurring in culture media of Aspergillus oryzae.


A simple chemical method for labelling phosphatidylcholine and sphingomyelin in the choline moiety.


Metabolism of sphingosine bases. XVI. Studies on the stereospecificity of the introduction of the hydroxy group of 4D-hydroxyspinganine (phytosphingosine).


Molecular weight of yeast pyruvate kinase.


Free-flow electrophoretic separation of lymphocytes. Evidence for specific organ distributions of lymphoid cells.


-chymotrypsin: selective hydrolysis of tyrosyl-tRNA Tyr  and phenylalanyl-tRNA Phe .


Modification of the single arginine residue in insulin with phenylglyoxal.


Vitamin A degradation products encountered on vitamin A analysis. I. The structures of retrovitamin A, anhydrovitamin A, and isoanhydrovitamin A.


The effect of thyroid activity on the enzymes of vitamin A metabolism and on the stability of lysosomes.


The relationship between the storage forms of vitamin K and dietary phylloquinone in the dog.


Studies on the intestinal absorption and metabolism of phytylubiquinone-(1',2'- 3 H) (hexahydroubiquinone-4) in man.


Gas chromatography--mass spectrometry of hexahydroubiquinone-4 and related compounds. A critical examination of analytical procedures.


In vivo incorporation of L-(U- 14 C) lysine and L-(U- 14 C) leucine into brain proteins in pyridoxine deficiency.


Erythrocyte transaminase activity in human vitamin B 6  deficiency.


Erythrocyte glutamic oxaloacetic transaminase activity in patients with oral lesions.


The relationship between leucocyte ascorbic acid concentrations and the total white blood cell count.


The relationship between leucocyte ascorbic acid and haemoglobin levels at different ages.


Regulation of erythropoiesis in the fetal rat.


Erythropoiesis inhibiting factor in urine.


Erythropoietin formation in rats bearing congenital hydronephrosis.


Adsorption of diacetyl by lactose and other sugars.


Regulation of erythropoiesis in the newborn rat.


The hemagglutination-inhibition assay for erythropoietin. Its specificity, reproducibility and sensitivity.


Thermoregulatory control in cattle exposed to the natural climate.


Retention and transfer of mediation set in paired-associate learning of educable retarded children.


A radioimmunoassay for human urinary erythropoietin.


Erythropoietin production and utilization in fetal goats and sheep.


Inhibition of erythropoiesis by plasma from newborn infants.


The effect of erythropoietin and erythroid hyperplasia on the response of rabbit bone marrow to actinomycin D.


Effects of verbal and pictorial elaborations on associative learning and response learning in a children's paired-associate task.


The feedback regulation of erythroid clones from adult and fetal origin.


Interaction among anxiety, stress, response mode, and familiarity of subject matter on achievement from programmed instruction.


Adjustment of Anglo-American and Mexican-American pupils in self-contained and team-teaching classrooms.


Erythropoietic effect of testosterone administered to male rats by the percutaneous or subcutaneous route. Comparison between the renotrophic, androgenic and erythropoietic effect of the hormone.


Erythropoietic islands in rat bone marrow in different functional states. I. Changes in primary hypoxia.


Differences between in vivo and in vitro activities of various erythropoietin preparations.


Microscopic fat cell size measurements on frozen-cut adipose tissue in comparison with automatic determinations of osmium-fixed fat cells. Diameters of fat cells in adipose tissue slices, floating in an isoosmolar solution, were measured under a microscope. The slices were obtained from percutaneous biopsies by freeze-cutting after brief formaldehyde fixation. All cells in a given part of the slice were measured, thus avoiding selection. A normal distribution of fat cell diameters could be demonstrated with this method, as has been found with previously described methods. The error of the method was 2.6% for diameter and 8.0% for weight determinations. Storage of adipose tissue at 4 degrees C for 48 hr had no effects on cell size determinations. Results with this microscopic method were compared with those obtained from a previously described method for automatic determinations of osmium-fixed fat cells. The latter method was slightly modified by using a viscous electrolyte, which prevented sedimentation of large fat cells, and by using sonication to complete cell separation. The methods agreed closely. A method for calculating mean fat cell weight using osmium-fixed fat cells is described, which makes determinations of sample wet weight and ratio of lipid to wet weight unnecessary.


Partial characterization of an antiserum to erythropoietin.


Effect of uremia on the in vitro response of human marrow cells to erythropoietin.


Lipid composition of rat brain myelin in triethyl tin-induced edema. Chronic triethyl tin intoxication was induced in young adult rats by oral feeding of triethyl tin sulfate. Progressively severe brain edema developed during the 3-month experimental period. The yield of myelin from the brains of the experimental animals decreased to almost half normal per brain, but the isolated myelin appeared morphologically normal. The analysis of whole brain showed corresponding decreases in proteolipid protein and total lipid, particularly galactolipids. The proportions of the major constituents of isolated myelin (chloroform-methanol-insoluble residue, proteolipid protein, and total lipid) were unchanged despite the low yield. However, the proportion of cholesterol increased from 16 to 21% dry weight, and that of total galactolipid decreased from 21 to 15%, as the yield of myelin decreased. This decrease of total galactolipid was mainly due to the decrease in cerebroside. Total phospholipid remained constant initially but showed a slight decrease toward the end of the experiment, due mostly to decreased ethanolamine phospholipid. There was no preferential loss or preservation of phosphatidalethanolamine. The fatty acid composition of sulfatide showed statistically significant shifts to less long-chain fatty acids and less monoenoic acids, but cerebroside and sphingomyelin did not show significant changes in the fatty acid composition. There was no increase in esterified cholesterol. These findings generally support our hypothesis of nonspecific chemical abnormalities of the myelin sheath undergoing secondary degeneration. In an acute experiment, a single intraperitoneal injection of triethyl tin sulfate produced acute and transient brain edema. There were slight decreases in the yield of myelin, but no detectable changes in the chemical composition.


Extrarenal erythropoietin production.

Extrarenal erythropoietin production.


Mechanisms of erythropoietin production.


An electron microscopic study of endogenous very low density lipoprotein production in the intestine of rat and man. Previous studies have shown that in the absence of dietary lipid, intestinal lymph contains endogenous very low density lipoproteins (VLDL) which are identical to those in plasma in size, flotation rate, composition, and electrophoretic mobility. In order to document that these particles are produced in the mucosa of the small intestine itself, electron microscopic studies of rat and human intestinal mucosa were carried out. Small intestinal absorptive cells from rats fasted and restrained for 48 hr were rich in osmiophilic particles of the size of VLDL (300-1000 A). These particles were present in the endoplasmic reticulum and Golgi apparatus, and in intercellular spaces and lacteals; they were most abundant in mucosa from mid-jejunum. Similar particles were seen in jejunal mucosal biopsy specimens obtained from normal human volunteers after a 40-hr fast. After 6 hr of bile diversion or cholestyramine administration to fasted rats, the VLDL-sized particles virtually disappeared from the mucosa, suggesting that they were produced in the mucosa itself and depended upon the absorption of endogenous intralumenal lipid. These studies provide further evidence for the production of VLDL in absorptive cells of fasting rat and human intestine, and support the concept that the small intestine is a source of endogenous plasma VLDL.


Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat. The effect of feeding a semipurified diet high in sucrose on serum lipid and lipoprotein concentrations was studied. In rats fed this diet the serum triglyceride concentration doubled, and liver triglyceride concentration increased by 30%. A fivefold increase in VLDL protein concentration and a small but significant increase of HDL protein concentration was also observed. In these rats there was increased incorporation of labeled amino acids into the proteins of plasma VLDL and HDL. Fatty livers developed in the animals receiving 4-aminopyrazolopyrimidine, and levels of serum triglyceride and cholesterol fell markedly. The concentration of all lipoprotein classes decreased, with VLDL showing the most marked effect. Incorporation of labeled amino acids into lipoproteins and other plasma proteins was depressed.


Micellar properties of sodium fusidate, a steroid antibiotic structurally resembling the bile salts. The properties of sodium fusidate micelles were determined by a spectral shift technique, surface tension measurements, and ultracentrifugal analysis. The critical micellar concentrations, mean molecular areas, and apparent aggregation numbers were estimated as a function of the concentration of counterion (0.001-1.0 m Na(+)) at 20 degrees C. The critical micellar concentrations were studied over a temperature range of 10 degrees C to 40 degrees C at one counterion concentration (0.001 m Na(+)), and from these data the standard thermo-dynamic functions of micellization were calculated. The ability of sodium fusidate solutions to solubilize the insoluble swelling amphiphiles, lecithin and monoolein, was investigated, and the results were compared with the solubilizing properties of sodium taurocholate. The critical micellar concentrations of sodium fusidate approximated those of sodium taurocholate. The values fell in the range of 1.44-4.56 mm, varying with the technique used, counterion concentration, and temperature. The percentage of counterions bound to fusidate micelles in water, calculated from the log critical micellar concentration-log Na(+) curve, was estimated to be negligible, which compares with sodium taurocholate micelles. The critical micellar concentration of sodium fusidate exhibited a minimum at 20 degrees C, a phenomenon observed with other ionic detergents and with bile salts. Micelle formation in sodium fusidate solutions was shown to be primarily entropy-driven at 10 degrees and 20 degrees C, whereas at 30 degrees and 40 degrees C the enthalpy factor predominated. From the surface tension measurements the molecular areas of sodium fusidate and sodium taurocholate were calculated. The mean molecular area of fusidate was 101 A(2), whereas sodium taurocholate possessed a molecular area of 88 A(2). It was demonstrated that the sodium fusidate molecule, like a bile salt molecule, lies with its longitudinal axis horizontal at an air-water interface. The apparent aggregation number of sodium fusidate micelles increased from 5 to 16 as the concentration of counterion increased from 0.01 to 0.60 m Na(+). These values are slightly larger than the corresponding aggregation numbers of sodium taurocholate micelles.


Utilization of exogenous free fatty acids for the production of very low density lipoprotein triglyceride by livers of carbohydrate-fed rats. High carbohydrate diets enhance the hepatic output of very low density lipoprotein triglycerides. The fatty acids of these triglycerides could come from exogenous sources (i.e., diet or adipose tissue) or from de novo fatty acid synthesis in the liver. The role of exogenous free fatty acids was evaluated in rats fed Purina Chow or diets containing 10% fructose for up to 14 wk. In carbohydrate-fed rats, serum triglycerides were twice normal, and VLDL accounted for about 60% of the increases. Pre-beta-lipoprotein was increased and alpha- and beta-lipoprotein were decreased. Phospholipid and cholesterol levels were unchanged. Livers were perfused with glucose and free fatty acids. Perfusate free fatty acids rose from 180 to 1800 micro eq/liter as the infused acids increased from 0 to 992 micro eq/3 hr; simultaneously, net free fatty acid uptake rose from < 1 to 18 micro eq/g/hr and triglyceride output by the liver doubled. However, rates of secretion of triglyceride became constant, and triglyceride accumulated in liver at uptakes of free fatty acids > 13 micro eq/g/hr. More lauric and myristic acid appeared in the perfusate than was infused, suggesting the hepatic discharge of free fatty acids. Livers of fructose-fed rats secreted twice as much oleate-(14)C-labeled triglyceride as controls at all levels of free fatty acid uptake. The ratios of the specific activities of perfusate triglyceride to free oleate-(14)C were unaffected by diet and were about 0.6 and 1.0 at low and high triglyceride secretion rates, respectively. Thus, carbohydrate feeding did not result in altered uptakes of free fatty acids or preferential secretion of triglycerides containing endogenously synthesized fatty acid. Instead, the increased secretion of triglyceride was accomplished by enhanced formation of VLDL triglyceride from exogenous free fatty acids.


Utilization of fatty acids in perfused hypothermic dog kidney. Utilization of oleic acid in whole dog kidneys perfused in vitro for 24 hr at 10 degrees C was studied, and the data were correlated with results on the utilization of oleic acid in kidney slices incubated in the same perfusate at 10 degrees C. Kidneys perfused without added oleate lost 35% of their total lipid content and 27% of their phospholipids. Addition of serum albumin-bound oleate to the perfusate prevented the loss of neutral lipid and reduced the loss of phospholipid to 8%. The kidney slices incorporated 29% of the added oleate into lipid and oxidized 3.2% to CO(2). Oleate apparently largely replaces endogenous fatty acids which are oxidized to meet the energy requirements of the kidney. The loss of phospholipid from the perfused organ is taken as an indication of cell damage, which may be reduced but is not prevented by the addition of oleate to the perfusate.


Mass spectrometry of the phosphatidylcholines: fragmentation processes for dioleoyl and stearoyl-oleoyl glycerylphosphorylcholine. Mass spectra for the various phosphatidylcholines, together with accurate mass measurements on the more abundant fragment ions, have been described in a previous paper (Ref. 5). No detailed fragmentation sequence was proposed on the evidence available. In the case of dioleoyl glycerylphosphorylcholine, some question arose as to whether certain ions were produced by electron impact or by pyrolysis. In this paper, results are reported which enable a more detailed fragmentation sequence to be proposed. By observing metastable transitions in the first field free region of a double-focusing mass spectrometer, it can be shown that the major ions in the spectrum are produced by electron impact processes, and not by pyrolysis; moreover, many of these ions are directly related to one another by metastable processes. In particular, it has been demonstrated that the ions at m/e 603 for dioleoyl glycerylphosphorylcholine and at m/e 604 for stearoyl-oleoyl glycerylphosphorylcholine are derived from the appropriate molecular ions by an electron impact-induced process. From measurements of the metastable ion intensities, as well as from the appearance potentials and ionization efficiency curves, conclusions may be drawn about many of the fragmentation mechanisms, allowing a distinction to be made between rearrangement and cleavage reactions.


Loss of lipid to plastic tubing.

Loss of lipid to plastic tubing. 14C-labeled oleic acid and (3)H-labeled monoether in a bile salt solution were perfused through three types of plastic tubing. Large proportions of lipid were lost to the walls of silicone rubber and polyvinyl chloride tubes. The major portion of the lipid lost was recoverable only when chloroform-methanol was perfused through the tubings. On the other hand, very little lipid was lost to the wall of polyethylene tubing. Polyethylene tubing should therefore be used in perfusion studies involving lipid-soluble compounds.


Artifacts produced by boron trifluoride methanolysis of a synthetic lecithin containing cyclopropane fatty acids (1-2-dihydrosterculoyl-3-sn-phosphatidylcholine). It is shown that methanolysis of dihydrosterculoyl lecithin with boron trifluoride-methanol introduces artifacts which are absent if the methyl ester is prepared by saponification of the lipid followed by treatment with diazomethane.


Tooth replacement in the red-backed salamander, Plethodon cinereus.


Structure and sensory apparatus of oral remnants of the nasopalatine canals in the fin whale (Balaenoptera physalus L.).


Light microscopic studies on the pineal organ in teleost fishes with special regard to its function.


Comparative cardiac anatomy of the reptilia. I. The chambers and septa of the varanid ventricle.


Hexose phosphate levels in testes of galactose-fed rats.


Effects of seminal plasma on the fertilizing capacity of rabbit spermatozoa in relation to the time of ovulation.


Serum luteinizing hormone during the pregnancy of a Zebu cow.


Elimination of spermatozoa in the urine of isolated male rats.


Selective chemotaxis of macrophages towards human and guinea-pig spermatozoa.


The relation of the proteolytic activity of human seminal plasma to various semen characteristics.


Output of oestriol in relation to duration of human labour.


Menstrual blood loss and haematological indices.


The effect of a single dose of cadmium chloride on the phospholipid fatty acids of the rat testis.


Effect of storage at 5 degrees C on the disc electrophoretic patterns of ovine and bovine seminal proteins.


Distribution of cholinergic vasomotor nerves to the parametrial arteries of some laboratory and domestic animals.


Arteriographic evidence for a cholinergic dilator mechanism in uterine hyperaemia of pregnancy in the guinea-pig.


An association of endoplasmic reticulum with the Golgi apparatus in golden hamster spermatids.


Gonadotrophin excretion in ovariectomized bitches.


Protein metabolism of the rat uterus during the oestrous cycle, pregnancy and pseudopregnancy, and as affected by an anti-implantation compounds, ICI 46,474.


Sperm production of boars as measured from epididymal sperm reserves and quantitative testicular histology.


Effects of 10 weeks of endurance training on left ventricular intervals.


Varied responses to severe physical training demonstrated by three middle-aged men.


The comparison of the W 170  values during growth.


Effect of calisthenics on strength, muscular endurance and total body reaction and movement times.


Personality profiles of non-swimmers among university women.


Energy requirements during exercise in the water.


The effect of acetylsalicylic acid on free fatty acids in blood and possible relationship to aerobic performance.


Anabolic steroid effects on body composition in normal young men.


A country medical examiner's office: the roles of physicians in private practice and the hospital-based pathologist.


The viewbox. Pericardial lipoma.

The viewbox. Pericardial lipoma.


Elevations of the serum alkaline phosphatase after infusions of albumin.


Renal lesions in streptococcal pyoderma.


Atrial fibrillation and hypokalemia.

Atrial fibrillation and hypokalemia.


Perinatal tips.

Perinatal tips.


50 students learn at Michigan community hospitals; MSMS project.


Economist outlines alternatives for attacking health problems.


Guilmet v. Campbell. Crisis? Confusion? Comedy?


Drugs and folic acid utilization.

Drugs and folic acid utilization.


Considerations in agricultural planning.


Fetal bradycardia after paracervical block.


Surface ultrastructure of human amnion and chorion in early pregnancy: a scanning electron microscope study.


Assessment of fetal size and growth rate by ultrasonic echoscopy.


Biochemical studies of the fetus. V. Fetal pCO 2  and Apgar scores.


Induction of labor with prostaglandin.

Induction of labor with prostaglandin.


Carcinoma of the corpus uteri: a 10-year review of 225 patients.


Perinatal genital hematomas.

Perinatal genital hematomas.


Outcome of illegitimate conceptions in a black population. Field interviews were conducted to gather data on pregnancy wastage and illegitimacy among 990 urban black women in a North Carolina Standard Metropolitan Statistical Area.  The sample range in age from 15-39, was at least gravida 1, and was at the poverty level (based on relationship of family size to income).  90% of births were illegitimate with little influence from economic status or income, but higher educational levels were associated with a greater percentage of conceptions resulting in illegitimate live births.  The older the women, the lower was the proportion of illegitimate conceptions resulting in illegitimate births.  In groups aged 15-24, and 30-39, there was a positive relationship between education and percentage of illegitimate live births, possibly due to general good health, awareness of health facilities for the more educated, and a reluctance to  view abortion as acceptable.  In this group aged 25-29, higher education was negatively related to illegitimate births, possibly explained by the relatively better health of this group, regardless of knowledge or availability of health care, and their tendency to view  abortion as acceptable.  Only 4% saw having children as a handicap to getting married.  Only 9.7% of all conceptions which were terminated could have been via abortion, which is indicative of the corresponding attitudinal survey where 77% of the sample were opposed to abortion under any circumstances.


Serum iron-TIBC in the diagnosis of iron deficiency anemia during pregnancy.


Leiomyosarcoma of the uterus. A clinicopathologic study.


Leiomyosarcoma of the uterus.

Leiomyosarcoma of the uterus.


Risk of rubella vaccination during pregnancy.


The internal os--a neglected sign.

The internal os--a neglected sign.


Cholesterol biosynthesis in human fetal liver and adrenal.


Metabolism of 1-dehydroandrostanes in man. I. Metabolism of 17 -hydroxyandrosta-1,4-dien-3-one, 17 -cyclopent-1'-enyloxyandrosta-1,4-dien-3-one (quinbolone) and androsta-1,4-diene-3,17-dione (1).


Liquid-gel chromatography on hydrophobic Sephadex and competitive protein binding of 17 -hydroxyprogesterone in plasma.


The prediction of standard curves and errors for the assay of estradiol by competitive protein binding.


Reactions of HL-A antissera in three populations.


The inheritance of the blood group gene M k  and some considerations on its possible nature.


Discelectrophoretic variation of human serum lipoproteins (LDL). Further family data on the inheritance of the E1(C) system.


Tr: a canine red cell antigen related to the A-antigen of human red cells.


Low incidence of erythrocyte G-6-P D deficiency in Vietnamese and Montagnards of South Vietnam.


Production of antibody against Australia antigen in horses.


A technique for lymphocyte preparation from stored heparinized blood.


The ultrastructure of the epidermis and associated structures in the metacercaria cercaria and sporocyst of Diplostomum phoxini (Faust, 1918).


Fine-grained secretory cells in the intestine of the lancelet, Branchiostoma (Amphioxus) laneceolatum studied by light microscopy.


Ultrastructure of the enlargec cecum in germfree rats.


Spatial specificity of local habituation to cold.


A fifth modality of taste.

A fifth modality of taste.


Aspects of the cardiovascular nervous control in a mammalian diver (Myocastor coypus).


Stability of (Mg 2+ ) in cerebrospinal fluid during plasma changes and during hypercapnia in young and in adult rats.


Changes in cerebral blood volume of mice at various time-periods after superior cervical sympathectomy.


Osteopoikilosis: a case report and a suggestion of its pathogenesis.


A new approach to the excision of Dupuytren contractures in the hand.


On the relation between the chorda tympani nerve response, arterial oxygen tension and blood flow in the tongue of the rat.


Alterations in intracranial pressure, blood-brain barrier, and brain edema after sub-chronic implantation of a cannula into the brain of conscious animals.


Influence of changes in microcirculation on the excitability of the sensory unit in the tooth of the cat.


Studies on cardiac ventricular receptors. A preliminary report.


Lipids of the sympathetic nerve trunk vesicles. Comparison with adrenomedullary vesicles.


Field study of transport aircrew workload and rest.


Clinical use of radiostrontium in evaluation of orthopaedic diseases.


Decompression sickness: a fundamental study of "surface  excursion" diving and the selection of limb bends versus C.N.S. symptoms.


Pulmonary capacity for dissipation of venous gas emboli.


Study of reactivity of the organism exposed to transverse accelerations and radioprotectants.


Effect of increased pressures of normoxic helium, nitrogen and neon on EEG and reaction time in man.


[Effect of acclimatization to altitude and cold on basal heart rate, blood pressure, respiration and breath-holding in man].


Noise and aircrew effectiveness.

Noise and aircrew effectiveness.


Studies on dysbarism. IV. Production and prevention of decompression sickness in "non-susceptible" animals.


Changes in human urine and blood chemistry during a simulated oxygen-helium dive to 1,500 feet.


Vascular and extravascular fluid changes during six days of bedrest.


Heat acclimatization by the prevention of evaporative cooling.


Physiological responses to cooling the head and neck versus the trunk and leg areas in severe hyperthermic exposure.


Epidemiology of USAF spatial disorientation aircraft accidents, 1 Jan 1958-31 Dec 1968.


Aeromedical consultation service case report: exercise-induced bronchospasm.


Clinical cases of sickle cell trait.

Clinical cases of sickle cell trait.


Vaginal adenocarcinoma arising in vaginal adenosis.


Radioimmunoassayable plasma luteinizing hormone in primary amenorrhea. Plasma luteinizing hormone (LH) was detectable by radioimmunoassay in 35 patients, all with female external genitalia, who had never menstruated spontaneously.  Patients were grouped as follows: 11 with hypogonadotropic hypogonadism (1 pituitary dwarf, all with normal sex chromatin) 16 with gonadal dysgenesis (5 XO, 5 XX, 2 XY, 3 mosaics), and 8 with uterovaginal atresia (normal karyotypes.)   Radioimmunoassay was performed with rabbit anti-human chorionic gonadotropin labeled with iodine-125, by the polystyrene tube method, on plasma samples taken at 9-11 a.m.  Hypogonadism patients had mean 9.1 mI.U.  LH (range 0-18); gonadal dysgenesis patients had mean 61.5 (range 23-103); uterovaginal atresia patients had 11.9 (0-35).  It was noteworthy that no overlap was observed between primary gonadal failure (gonadal dysgensis), and secondary (hypogonadism), and that LH values in 2 other patients with polycystic ovaries, LH was 16 and 34 mI.U. and FSH was not  increased.


Rape: the medical, social, and legal implications.


In vitro binding of progesterone by the human endometrium during the menstrual cycle and by hyperplastic, atrophic, and carcinomatous endometrium.


Congenital toxoplasmosis: a prospective study of 4,048 obstetric patients.


Optimal dosage of buccal oxytocin for the induction of labor.


The role of toxoplasmosis in abortion.

The role of toxoplasmosis in abortion.


The effect of prostaglandin F 2 and E 2 on blood glucose and plasma insulin levels during pregnancy.


Observations of maternal weight behavior during the puerperium.


Quantitative amino acids in amniotic fluid and maternal plasma in early and late pregnancy. Preliminary report.


The metabolic effects of a hypertonic fructose infusion on the mother and fetus during labor.


Action potential of human myometrial fibers.


Spontaneous rupture of the kidney associated with pregnancy.


Observation of fetal cardiac motion by M-mode ultrasonic cardiography.


Unilateral control of uterine blood flow in the ewe.


Pregnancy and nephrotic syndrome due to renal amyloidosis.


The forgotten pessary: a medical oddity.


An incisional hernia containing an incarcerated twin pregnant uterus.