Progressive supranuclear palsy (the Steele-Richardson-Olszewski syndrome). A report of 9 cases with particular reference to the mechanism of the oculomotor disorder.


Morphological studies on normal and diseased human muscle in culture.


Avitaminosis E: organ distribution of aryl sulfatase elevation.


Proten composition of white matter myelin in subacute sclerosing panencephalitis.


An electron microscopic comparison of motor end-plates of slow and fast skeletal muscle fibres of the mouse.


( 131 I)Triiodothyronine transport into rat cerebral cortex slices.


An electron microscopic study of the changes induced by botulinum toxin in the motor end-plates of slow and fast skeletal muscle fibres of the mouse.


Changes in the electron microscopic structure of slow and fast skeletal muscle fibres of the mouse after the local injection of botulinum toxin.


The clinical and roentgenological course of deep-vein thrombosis.


Experiences with a doctor-manned ambulance service in Oslo.


Editorial: treatment of girls with urinary infection and nothing else.


Pheochromocytoma associated with parathyroid adenoma. Report of a case and review of literature.


Postoperative renal vein thrombosis in a solitary kidney.


Renal papillary necrosis: management by ureteral catheter drainage.


The renal lymphatic system during obstructed urine flow.


Traumatic renal sequestration with segmental hydronephrosis: report of a case.


Percutaneous femoral vein catheterization in patients requiring hemodialysis.


Gold leaf in urologic surgery: clinical application.


Pseudo-tumors of the kidney secondary to anticoagulant therapy.


Spontaneous rupture of the renal collecting system caused by unsuspected hypernephroma presenting as ureteral calculus disease.


Clear cell carcinoma of the free wall of a simple renal cyst.


General treatment, mistreatment and complications of ureteroceles.


Congenital mid-ureteral stricture in a solitary kidney.


Symptomatic ureteral stumps.

Symptomatic ureteral stumps.


Ureteral guide to aid in spatulation of ureter and placement of sutures for uretero-intestinal anastomosis.


Bladder carcinoma in rubber workers.

Bladder carcinoma in rubber workers.


Internal urethrotomy with hydraulic urethral dilatations.


Carcinoma of the cervix involving the upper urinary tract.


Androblastoma (Sertoli-cell tumor).

Androblastoma (Sertoli-cell tumor).


Prednisone in the treatment of acute epididymitis: a cooperative study.


The value of preoperative lung scanning in the assessment of postoperative perfusion abnormalities.


Myeloma of the prostate: a case report.

Myeloma of the prostate: a case report.


Carcinoma of the prostate with metastases to the prepuce.


Vesicoureteral reflux in children.

Vesicoureteral reflux in children.


Incomplete lambda bacteriophage heads produced by a gene F mutant. The defective head subassembly produced when lambdasusF423 grows in a nonpermissive host is made functional by a factor in other mutant lysates.


Temperature-shift analysis of bacteriophage phi 29 gene expression in Bacillus amyloliquefaciens. Temperature shift-up experiments with conditional lethal mutants of Bacillus phage phi29 have allowed placement of early, middle, and late functions on the linear phi29 genetic map Most of the phi29 cistrons are late and are found at the ends of the map.


Performance of single letters and pairs of letters in short-term recognition experiments.


Comment on feedback training of parietal-occipital alpha asymmetry in normal human subjects.


Drug abuse of the innocents.

Drug abuse of the innocents.


Diagnosis: gas in the fetal circulation.


Neonatal heroin (diacetylmorphine) addiction.


The treatment and rehabilitation of heroin addicts.


The psychodynamics of the 'bad trip'.

The psychodynamics of the 'bad trip'.


Detroit anesthesiologists challenge statements of halothane article.


Health care delivery in he United States.


MSMS survey shows physicians' earnings rising slower than costs of practice.


Changing patterns of amphetamine abuse: the role of the physician.


Pharmacokinetics of Cytembena in man.

Pharmacokinetics of Cytembena in man.


Contribution to elucidation of biochemical action mechanism of Cytembena.


Cytembena administered in combination with cyclophosphamide in Yoshida ascitic sarcoma.


Cytembena treatment of advanced gynaecological carcinomas.


Cytembena treatment of advances and relapsing uterine cervix carcinoma.


Local effect of Cytembena and Bucky's rays on superficial basaliomas and Bowen's disease.


Fluoxydin. (Preliminary report on clinical evaluation).


Further study of artificial heterogenization of tumours in the course of chemical carcinogenesis.


The effect of dibromodulcitol (NSC 104800) on intravenously induced cytemia of rats.


The activity of serum alkaline phosphatase in menopausal patients with endometrial carcinoma (II communication).


An improved needle set for fistula hemodialysis.


Renal transport of diatrizoate in the rabbit, dog, and rat.


Sinus pericranii--angiographic demonstration.


Primary enlarged "empty" sella.

Primary enlarged "empty" sella.


Abeyance of haemorrhage by (LN2) "cryospray" during meningioma removal.


Cavernous sinus carotid aneurysm treated by artificial embolization.


The kininogen content of rat plasma after intravenous or subplantar administration of glass powder, kaolin or carrageenin.


Pharmacological receptors in the rat stomach fundus. Considerations on the thermal alteration.


Effect of aethimizol on water and electrolyte excretion.


Modification of polypeptide activity by cysteine analogs: structure-activity relationship.


[Cardiac tamponade in advanced chronic renal failure. Current experience. Apropos of 6 cases].


High risk infant facilities.

High risk infant facilities.


Primary congenital malignant mesenchymoma of the eyelid.


Maple syrup urine disease.

Maple syrup urine disease.


Psoriasis vulgaris as an immune-deficiency condition. Its etiology, pathogenesis, and specific vaccine therapy.


A working model of clinical research in private practice.


The effect of two tetrahydrocannabinols, (  9 -THC and   8 -THC) on conditioned avoidance learning in rats and its transfer to normal state conditions.


Behavioural and physiological effects of cigarette smoking in a monotonous situation.


Effects of haloperidol, trifluperidol, nitrazepam and chlordiazepoxide upon conditioned midbrain behavioral responses.


Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli.


Ethanol intake in the absence of concurrent food reinforcement.


Effect of hashish smoke sublimate on hypothalamic noradrenaline studies by the fluorescence method.


The effects of different amino acid diets on a fast-induced performance decrement in mice.


Joint effects of medial septal lesions and amylobarbitone injections on resistance to extinction in the rat.


Factors affecting the rate of hydrated electron attack on polynucleotides.


Distribution of  134 Cs in the conceptus of pregnant rat.


Induction of heteroallelic reversions and lethality in Saccharomyces cerevisiae exposed to radiations of various LET ( 60 Co   rays, heavy ions and   -  mesons) in air and nitrogen atmospheres.


Alteration of taste thresholds in the rat following low dose x-irradiation.


Radiation effects on water permeability and distribution in frog muscle cells.


Effectiveness of tranquilizing drugs in rats exposed to mixed gamma-neutron radiations.


Mechanisms of acute injury in the  -irradiated chicken. In vivo studies of dose protraction effects on the microvasculature.


Toward the reduction of unwanted pregnancy. An assessment of current public and private programs.


Protein methylation.

Protein methylation.


Kidney: primary source of plasminogen after acute depletion in the cat. The kidney was the primary source of plasminogen to restore normal plasma levels, after acute plasminogen depletion was produced by injection of streptokinase in cats. The concentration of plasminogen in the hepatic vein remained below that in the artery during the time when concentrations in the artery and renal vein were returning to normal.


Diethylamide of thujic acid: a potent repellent of Aedes aegypti. A series of novel, representatively substituted amides of thujic acid were prepared and screened for insect repellent and attractant potential. In repel-lency tests the N,N-diethylamide was the most potent compound, surpassing the activity of the standard repellents dimethyl phthalate and fencholic acid. In contrast, the N-monoethylamide displayed attractant activity.


Binding of DDT to lecithin.

Binding of DDT to lecithin. An interaction between DDT and lecithin is indicated by the reciprocal effects of each compound on the proton magnetic resonance spectrum of the other. The phosphoryl choline moiety of the lecithin and the benzylic proton of the DDT seem to be involved. The most pronounced response in the proton magnetic resonance spectrum of the lecithin produced by increasing concentration s of DDT was a change in the chemical shift of the resonance peak due to the protons of the choline methyl groups. Increasing concentrations of lecithin produced changes in the chemical shift of the resonance peaks of the benzylic proton and adjacent ring protons of the DDT. Equilibrium constant of 0.597 +/-0.015 molal(-1) was obtained for this interaction.


Amino acid composition of proteins as a product of molecular evolution. The average amino acid composition of proteins is determined by the genetic code and by random base changes in evolution. Small but significant deviations from expected composition can be explained by selective constraint on amino acid substitutions. In particular, the deficiency of arginine in proteins has been caused by constraint, during evolution, on fixation of mutations substituting arginine for other amino acids.


Xeroderma pigmentosum: a rapid sensitive method for prenatal diagnosis. When normal human cells, capable of repairing ultraviolet-induced lesions in their DNA, are incubated in the thymidine analog 5-bromodeoxyuridine after ultraviolet irradiation, the analog is incorporated into the repaired regions. When such repaired cells are subsequently irradiated with 313-nanometer radiation and placed in alkali, breaks appear in the DNA at sites of incorporation of 5bromodeoxyuridine, inducing a dramatic downward shift in the sedimentation constant of the DNA. Cells from patients with the disease xeroderma pigmentosum, which causes sensitivity to ultraviolet, are incapable or only minimally capable of repair; such cells incorporate little 5-bromodeoxyuridine into their DNA under these conditions and, upon 313-nanometer irradiation and sedimentation in alkali, exhibit only minor shifts in DNA sedimentation constants. When fibroblasts developed from biopsies of normal skin and of skin from patients with xeroderma pigmentosum, as well as cells cultured from midtrimester amniotic fluid, were assayed in this fashion unequivocal differences between normal and xeroderma pigmentosum cells were shown. Xeroderma pigmentosum heterozygotes are clearly distinguishable from homozygous mutants, and results are available 12 hours after irradiation.


Iron- and riboflavin-dependent metabolism of a monamine in the rat in vivo. n-Pentylamine enters into intermediary metabolism by the action of monoamine oxidase. [1-(14)C] Pentylamine injected into rats is rapidly converted to (14)CO(2). The rate of catabolism decreases progressively in the course of nutritional iron deficiency, reaching about 60 percent of control values in 3 weeks. Feeding with iron yields control levels within 6 days. The catabolism of amyl alcohol, which shares a common pathway with n-pentylamine by way of valeric aldehyde, is not significantly affected by the deficiency. The results demonstrate that the maintenance of normal monoamine oxidase activity in vivo depends upon an adequate supply of dietary iron.


Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells. Each clone of BALB/c mouse embryo cells that has been tested can be induced to form C-type virus. The individual cells therefore contain a complete copy of the genetic information for making the murine RNA tumor viruses.


Hemispheric asymmetry of electrocortical responses to speech stimuli. In a group of normal adults, averaged cortical evoked responses to natural speech stimuli were recorded from scalp electrodes placed symmetrically over the two cerebral hemispheres at frontal, Rolandic, and temporoparietal leads. The amplitude of the most prominent component was consistently larger in left hemisphere derivations, with the major hemisphere difference observed in the temporoparietal records. These electrophysiological measures may be sensitive indicators of hemispheric specialization of function.


Structure and synthesis of a lipid-containing bacteriophage. VI. The spectrum of cytoplasmic and membrane-associated proteins in Pseudomonas BAL 31 during replication of bacteriophage PM2.


Inhibition of cauliflower mosaic virus multiplication by actinomycin D.


The biological basis and public health aims of young child feeding.


Cultural differences and the feeding of young children in the Caribbean.


Family incomes and nutrient cost of foods in the Caribbean area.


Preparation for breast feeding.

Preparation for breast feeding.


Nutritional requirements in pregnancy and lactation.


Dietary deficiency and pre-eclamptic toxaemia--a preliminary communication.


The feeding of the newborn in hospital--an obstetrician's view.


Feeding of the newborn in hospital--paediatrician's view.


Minerals and vitamins.

Minerals and vitamins.


Some information about feeding practices in the Eastern Caribbean.


Transition to family diet in Jamaica and Barbados.


Weaning practices from Guyana, rural Trinidad (Fishing Pond Village) Grenada, Montserrat and Antigua.


Pattern of weaning in Dominica.

Pattern of weaning in Dominica.


A study on tissue tolerance for medical grade tubings--a contribution to a safer conduct of intra-arterial chemotherapy.


Fine structure of averaged potentials in man.


Orthopaedic--surgical prophylaxis of secondary arthroses of the hip.


Performance efficiency of men breathing oxygen-helium at depths between 100 feet and 1500 feet.


Noise: a hazard to divers and hyperbaric chamber personnel.


Application of college and flight background questionnaires as supplementary noncognitive measures for use in the selection of student naval aviators.


Cortical evoked response and inert gas narcosis in man.


Apollo 14 food system.

Apollo 14 food system.


Biochemical and physiological consequences of the Apollo flight diet.


Heart rate and respiration rate response to parachuting: physiological studies of military parachutists via FM-FM telemetry. II.


Effect of chronic microwave irradiation on the blood forming system of guinea pigs and rabbits.


Comments on Sjöberg's hypothesis for the mechanism of the inversion illusion under zero-gravity conditions.


Acceleration and opening shock forces during free-fall parachuting: physological studies of military parachutists via FM-FM telemetry. 3.


Case report of student aviator with unusual psychosomatic symptoms.


Report of a rapid decompression of a Boeing 707.


Hazard rate of recurrence in patients with malignant melanoma.


Disposable keratome blade and its use in cataract surgery.


Scleral depressor. Marker for retinal detachment surgery.


Reactions following intravenous fluorescein.


Influence of various agents on corneal permeability.


Incorporation of radioactive sulphate by corneal stroma during cryopreservation.


Intraocular pressure changes during hemodialysis.


Effect of ocular pigmentation on hypotensive response to pilocarpine.


A technique for conjunctivo-dacryocystorhinostomy.


Dermatophytosis affecting the periorbital region.


Iridogoniodysgenesis with cataract.

Iridogoniodysgenesis with cataract.


Catecholamine metabolite formation in the iris and ciliary body in vivo.


Sympathetic ophthalmia and lymphocyte transformation.


Sympathetic ophthalmitis.

Sympathetic ophthalmitis.


Evulsion of the optic nerve.

Evulsion of the optic nerve.


Modified ceiling-mounted zoom operating microscope.


Retinal changes in congenital poikiloderma.


Localization of the human visual evoked response. Early components specific to visual stimulation.


Modified Landolt rings and Sloan letters in adult visual acuity screening.


Carcinoma of the thyroid: review of fifteen years' experience. 1. Origin of spindle and giant cell carcinoma. 2. Occurrence of thyroid cancer in ectopic thyroid tissue.


Technic for resection of localized bullous disease of the lung.


Examination of the hand.

Examination of the hand.


Use of large and small bowel segments in urologic surgery: experiences with 396 segments.


Surgical correction of flexion deformities in hemophilia.


A university department of surgery.

A university department of surgery.


The status of permanent pacing of the heart in the United States and Canada.


Long-term cardiac stimulation in Belgium and Holland during 1969.


Survey of long-term stimulation techniques in Great Britain.


A survey of the long-term cardiac pacing in Japan.


Experience in permanent pacemaker implantation in Israel.


Survey of pacemaker treatment in Denmark, Finland, Norway and Sweden, in 1969.


Results of permanent cardiac pacing with Soviet implantable pacemakers.


Prevention and treatment of stimulation failures through the pervenous approach.


Comparison of function time of different pacemaker systems.


Atrial rate as an indicator for optimal pacing rate and the pacemaking syndrome.


Clinical experience of a biogalvanic pacemaker.


Atrial synchronized pacing using a new transvenous technique.


Clinical application of right atrial alternating current.


The development and evaluation of a nuclear powered pacemaker.


The American nuclear powered pacemaker.

The American nuclear powered pacemaker.


Long-term sequential atrial and ventricular pacing.


An aluminium silver-silverchloride biogalvanic cell.


Current status of atrial pacing.

Current status of atrial pacing.


Transvenous pacing in the child.

Transvenous pacing in the child.


Resistance of mice to Ehrlich ascites tumour after immunisation with live Salmonella enteritidis 11RX.


Enzyme treatment of colony stimulating factor: evidence for a peptide component.


QRS-triggered pacemaker and arrhythmias related to early systolic stimulation.


Cobalt-selenium interactions in the nutrition of the rat.


The vagal and sympathetic innervation of the heart of the lizard Tiliqua rugosa.


The pacemaker clinic of the University of Groningen (the Netherlands).


Toxicity of ouabain to embryonic chick lens.


Operation of a pacemaker clinic via telephone.


Variants in human serum albumin and caeruloplasmin in populations from Australia, New Guinea, South Africa and India.


The metabolism of cyclohexanol by Nocardia globerula CL1. 1. Nocardia globerula CL1, isolated by enrichment on cyclohexanol and grown with it as carbon source, oxidized it with a Q(o2) of 39mul/h per mg dry wt. and the overall consumption of 2.2mumol of oxygen/mol of substrate. Cyclohexanone, 2-hydroxycyclohexan-1-one dimer and cyclohexane-1,2-dione were oxidized with Q(o2) values similar to that for cyclohexanol whereas in-caprolactone and 6-hydroxycaproate were oxidized very slowly and adipate not all. 2. Disrupted cell suspensions could not be shown to catalyse the conversion of cyclohexanol into cyclohexanone. 3. A cyclohexanol-induced cyclohexanone oxygenase (specific activity 0.55mumol of NADPH oxidized/min per mg of protein) catalysed the consumption of 1mol of NADPH and 1mol of O(2) in the presence of 1mol of cyclohexanone. NADPH oxidation did not occur under anaerobic conditions. The only detected reaction product with 25000g supernatant was 6-hydroxycaproate. 4. Extracts of cyclohexanol-grown cells contained a lactone hydrolase (specific activity 15.6mumol hydrolysed/min per mg of protein), which converted in-caprolactone into 6-hydroxycaproate. 5. Incubation of 6-hydroxycaproate with 25000g supernatant in the presence of NAD(+) resulted in NAD(+) reduction under anaerobic conditions, oxygen consumption under aerobic conditions and the conversion of 6-hydroxycaproate into adipate. 6. Cyclohexanone oxygenase fractions devoid of in-caprolactone hydrolase catalysed the stoicheiometric formation of in-caprolactone from cyclohexanone in the presence of excess of NADPH. 7. The reaction sequence for the oxidation of cyclohexanone by N. globerula CL1 is: cyclohexanol --> cyclohexanone --> in-caprolactone --> 6-hydroxycaproate --> adipate. 8. It is suggested that the adipate may be further dissimilated by beta-oxidation.


The cellulase of Fusarium solani. Purification and specificity of the  -(1-4)-glucanase and the  -D-glucosidase components. 1. Cell-free culture filtrates of the fungus Fusarium solani were examined for homogeneity with respect to beta-d-glucosidase and C(x) activities. 2. o-Nitrophenyl beta-d-glucoside and cellobiose were both used as substrates for beta-d-glucosidase activity. 3. No evidence for the non-identity of nitrophenyl beta-d-glucosidase and cellobiase activities could be found, either by heat treatment, gel filtration on Sephadex G-100 or by isoelectric focusing. 4. The beta-d-glucosidase component was also a feeble exo-beta-glucanase: it had a molecular weight of approx. 400000. 5. The fall in viscosity of a solution of CM-cellulose, the formation of reducing sugars in a solution of CM-cellulose and the solubilization of phosphoric acid-swollen cellulose (Walseth cellulose), were all used for the measurement of C(x) activity. 6. The ratio of the two types of CM-cellulase activity was not changed after gel filtration on Sephadex G-100 or after chromatography on DEAE-Sephadex. 7. Three peaks of C(x) activity were obtained after electrofocusing, but all three possessed the same ratio of the two types of CM-cellulase activity as well as the same CM-cellulase/Walseth activity ratio, as the unfractionated enzyme; all three isoenzymes (isoelectric points, 4.75, 4.80-4.85 and 5.15) acted in synergism with a mixture of the C(1) and the beta-d-glucosidase components to the same extent in the solubilization of cotton fibre. 8. The molecular weight of the C(x) component was approx. 37000.


Chronic threshold measurement.

Chronic threshold measurement.


Chromatographic separation of mononucleotides derived from transfer ribonucleic acids. 1. A method is described for fractionating alkaline and enzymic hydrolysates of ribonucleic acids and oligonucleotides on DEAE-cellulose columns by using a constant-composition eluent. 2. The relative partition coefficients of the four major and several minor nucleotides present in nucleic acid digests are given. 3. The influence of pH and of molarity of the buffer on the separation is described. 4. Relations for the quantitative determination of the major nucleotides from their absorption zone areas on the chromatographic record are derived. 5. Hydrolysis of oligonucleotides with T2 ribonuclease yields solely the nucleoside 3'-monophosphates, thereby simplifying the subsequent chromatographic separation. 6. Examples of the qualitative and quantitative analysis of oligonucleotides from enzymic hydrolysates of RNA are given.


The present status of pacemaker clinics in England.


The inactivation of monamine oxidase by clorgyline (M & B 9302).


A monamine oxidase-tetrazolium reaction for locating aromatic amino acid decarboxylases in electrophoretic media.


The effects of salicylate of the activity of tryptophan pyrrolase in rat liver.


Calf N-acetylhexosaminidases.

Calf N-acetylhexosaminidases.


The metabolism of methoxyethylmercury salts. The metabolism of methoxy[(14)C]ethylmercury chloride in the rat has been investigated. After a single subcutaneous dose a small proportion is excreted unchanged in urine and a larger amount in bile with some resorption from the gut. The greater part of the dose is rapidly broken down in the tissues with a half-time of about 1 day to yield ethylene and inorganic mercury. Ethylene is exhaled in the breath and the mercury migrates to the kidney and is excreted in urine. A small proportion of the dose appears as carbon dioxide in the breath and about 12% in urine as a mercury-free metabolite. It is possible that the breakdown of methoxyethylmercurychloride to ethylene and inorganic mercury is not catalysed by an enzyme system.


Homoserine and diaminobutyric acid in the mucopeptide-precursor-nucleotides and cell walls of some plant-pathogenic corynebacteria. The nucleotide precursors of cell-wall mucopeptide were prepared by vancomycin inhibition of Corynebacterium insidiosum and Corynebacterium poinsettiae. The amino acid in the third position in the former peptide was shown by optical rotatory dispersion of the bisdinitrophenyl derivative to be l-diaminobutyric acid. Homoserine in the nucleotide from C. poinsettiae was catalytically oxidized to aspartic acid, which was then shown to be the l-isomer by optical rotatory dispersion of the trinitrophenyl compound. The sequence for C. insidiosum was UDP-N-acetylmuramyl-glycyl-isoglutamyl- (gamma-acetyl)-diaminobutyryl-alanyl-alanine. The cell walls of C. insidiosum and Corynebacterium sepedonicum contained diaminobutyric acid that was optically inactive. It is proposed, therefore, that the primary peptide chain contains the l-isomer with its gamma-amino group blocked by acetylation and that cross-linking is achieved by means of the d-isomer, analogous to d-ornithine in C. poinsettiae.


The effect of organic anions on the biliary excretion of tri (14C) methyl-(3-hydroxyphenyl) ammonium O-glucuronide.


The biochemical mode of action of the fasciolicides nitroxynil, hexachlorophane and oxyclozanide.


Biochemical effects of hypoglycaemic compound diphenyleneiodonium in rat liver mitochondria: inhibition of adenosine triphosphate synthesis.


N-carbamoyl-2-(p-hydroxyphenyl)glycine from leaves of broad bean (Vicia faba L.). 1. dl-2-(p-Hydroxyphenyl)glycine was resolved through the bromocamphorsulphonate to give its d-isomer. The N-carbamoyl derivatives of these amino acids were synthesized. Circular-dichroism studies on these and related compounds, reported in a deposited Annex, helped to establish the optical configuration. 2. N-Carbamoyl-dl-2-(p-hydroxyphenyl)glycine was isolated from broad-bean leaves. It amounted to about 0.1% of the leaf dry matter. Racemization may or may not have occurred during the isolation. There were indications of the same compound in chicory and in savoy cabbage. Under weakly acidic conditions it was converted gradually into 5-(p-hydroxyphenyl)hydantoin. Both these compounds yielded 2-(p-hydroxyphenyl)glycine on acid hydrolysis. 3. The occurrence is discussed of 2-phenylglycine derivatives in Nature and of N-carbamoyl-amino acids and hydantoins in plants. 4. Gradient elution from anion-exchange resin with acetic acid, besides proving useful for the present work, gave useful separations of pyrrolidonecarboxylic acid and of some N-acetyl-amino acids. 5. Supplementary material (Annex 1: details of experimental work other than ultraviolet and circular-dichroism spectra; Annex 2: ultraviolet absorption and circular dichroism of d-2-phenylglycine and some related compounds) has been deposited as Supplementary Publication SUP 50003 at the National Lending Library for Science and Technology, Boston Spa, Yorks. LS23 7BQ, U.K., from whom copies can be obtained on the terms indicated in Biochem. J. (1971), 121, 7.


Biochemical effects of the hypoglycaemic compound diphenyleneiodonium in rat liver mitochondria: anion-hydroxyl ion exchange.


The amino acid sequence of sesame (Sesamum indicum L.) and castor (Ricinus communis L.) cytochrome c. The amino acid sequences of sesame (Sesamum indicum L.) and castor (Ricinus communis L.) cytochrome c were determined by using 1.5mumol of protein from each species. Both molecules consist of a single chain of 111 amino acid residues and are homologous with other mitochondrial cytochrome c molecules. Both have an N-acetylated ;tail' of eight amino acids and two in-N-trimethyl-lysine residues, as also reported for wheat germ (Delange, Glazer & Smith, 1969) and mung-bean cytochrome c (Thompson, Laycock, Ramshaw & Boulter, 1970). Two different preparations of castor cytochrome c differed by one residue. This was glutamic acid for glutamine in position 100. The results for sesame and castor cytochrome c led to a re-examination and subsequent correction to the N-terminal region of the mung-bean cytochrome c sequence, as given by Thompson et al. (1970).


The biosynthesis of valine from isobutyrate by peptostreptococcus elsdenii and Bacteroides ruminicola. 1. Growing cultures of Peptostreptococcus elsdenii and Bacteroides ruminicola incorporate (14)C from [1-(14)C]isobutyrate into the valine of cell protein. With P. elsdenii some of the (14)C is also incorporated into leucine. 2. Crude cell-free extracts of both organisms in the presence of glutamine, carbon dioxide and suitable sources of energy and electrons incorporate (14)C from [1-(14)C]isobutyrate into valine but not into leucine. 3. With extracts of P. elsdenii treated with DEAE-cellulose the reaction is dependent on ATP, CoA, thiamin pyrophosphate, molecular hydrogen and a low-potential electron carrier (ferredoxin, flavodoxin or benzyl viologen). 4. The same extracts incorporate (14)C from NaH(14)CO(3) into valine in the presence of isobutyrate plus ATP, CoA, glutamine and ferredoxin; isobutyryl-CoA or isobutyryl phosphate plus CoA will replace the isobutyrate plus CoA and ATP. With acetyl phosphate in place of isobutyryl phosphate, (14)C is incorporated into alanine. With isovalerate or 2-methylbutyrate in place of isobutyrate, (14)C is incorporated into leucine and isoleucine respectively. 5. When carrier 2-oxoisovalerate is added to the carboxylating system (14)C from [1-(14)C]isobutyrate passes into the oxo acid fraction. 6. It is concluded that these two organisms form valine from isobutyrate by the sequence isobutyrate-->isobutyryl-CoA-->2-oxoisovalerate-->valine and that the reductive carboxylation of isobutyrate is catalysed by a system similar to the pyruvate synthetase of clostridia and photosynthetic bacteria.


Formation of malate from glyoxylate in animal tissues. 1. Incubation of rat liver homogenate with [1-(14)C]glyoxylate, ATP and acetate shows a rapid sequential incorporation of radioactivity into malate, oxaloacetate and citrate. 2. In liver from normal rats the rate of the formation of each substance in question is higher than that in liver from thiamin-deficient rats. 3. The net accumulation of malate is greater with liver from thiamin-deficient rats. Its further metabolism is retarded, it is suggested, by inhibitors formed by a condensation of glyoxylate and oxaloacetate.


The biosynthesis of gangliosides. The incorporation of galactose, N-acetylgalactosamine and N-acetylneuraminic acid into endogenous acceptors of subcellular particles from rat brain in vitro. Gangliosides bound to subcellular particles from rat brain were labelled by incubation of the particles (i) with CMP-N[(3)H]-acetylneuraminic acid and (ii) simultaneously, with CMP-N[(3)H]-acetylneuraminic acid and UDP-N-acetyl-[(14)C(1)]galactosamine or with CMP-N[(3)H]-acetylneuraminic acid and UDP-[U-(14)C]-galactose. Analysis of the labelled gangliosides showed that in (i), (a) the labelling was mostly in the neuraminidase-labile sialyl groups, (b) rigid relationships exist between the enzymes and the sialyl acceptors; the enzymes are not free to interact with all the specific substrates present in the preparation and (c) the precursor of the trisialoganglioside was the major disialoganglioside with a sialyl 2-->8 sialyl group. In (ii), (a) precursor-product relationships between the main pools of each ganglioside apparently do not exist, (b) for the labelling of Tay-Sachs ganglioside the amount formed from hematoside was at least 2.5 times that from aminoglycolipid and (c) the major monosialoganglioside was the precursor for the major disialoganglioside with a sialyl 2-->8 sialyl group.


Effect of thyroid hormone on metabolic compartmentation in the developing rat brain. 1. The effects of treatment with thyroid hormone (tri-iodothyronine) and of neonatal thyroidectomy on the cerebral metabolism of [U-(14)C]leucine were investigated during the period of functional maturation of the rat brain extending from 9 to 25 days after birth. 2. Age-dependent changes in the labelling of brain constituents under normal conditions appear to depend on changes in the availability of blood-borne [(14)C]leucine resulting from differential rates of growth of body and brain; but developmental changes in the pool size of free leucine and in the rates of protein synthesis and oxidation of leucine are also involved. 3. Treatment with thyroid hormone had no significant effect on the conversion of leucine carbon into proteins and lipids; and the age-dependent changes in the concentration and specific radioactivity of leucine were similar to controls. On the other hand there was an acceleration in the conversion of leucine carbon into amino acids associated with the tricarboxylic acid cycle. These observations indicate that leucine oxidation was the process mainly affected. 4. The specific radioactivity of glutamine relative to that of glutamate was used as an index of metabolic compartmentation in brain tissue. Treatment with thyroid hormone advanced the development of metabolic compartmentation. 5. Neonatal thyroidectomy led to a marked decrease in the conversion of leucine carbon into proteins and lipids and to a significant increase in the amount of (14)C combined in the amino acids associated with the tricarboxylic acid cycle. The age-dependent increase in the glutamate/glutamine specific-radioactivity ratio was strongly retarded. 6. The increased conversion of leucine carbon into cerebral amino acids applied to glutamate and aspartate, but not to glutamine and gamma-aminobutyrate. This observation facilitated the understanding of the effects of thyroid deprivation on brain metabolism and provided new evidence for the allocation of morphological structures to the metabolic compartments in brain tissue. 7. In contrast with the marked effects of the thyroid state on metabolic compartmentation, it had relatively little effect on the developmental changes in the concentration of amino acids in the brain. 8. The rate of conversion of leucine carbon into the ;cycle amino acids' both under normal conditions and in thyroid deficiency indicated a special metabolic relationship between glutamate and aspartate on the one hand, and glutamine and gamma-aminobutyrate on the other.


Factors controlling aminoacyl-transfer-ribonucleic acid synthesis in vitro by a plant system. 1. Factors affecting aminoacyl-tRNA synthesis in vitro by cell-free preparations from bean leaves were investigated. 2. Evidence was obtained that optimum concentrations as well as correct ratios of Mg(2+) and ATP are required for aminoacyl-tRNA synthesis in the bean-leaf system. 3. The results indicated that pH is a controlling factor having differential effects on the formation of individual aminoacyl-tRNA species. The possible micro-regulatory function of pH in protein synthesis in vivo is discussed with special reference to alanyl-tRNA formation. 4. Very low rates of alanine-stimulated pyrophosphate exchange were observed in the absence of tRNA. This observation is discussed relative to proposals about the mechanism of aminoacyl-tRNA synthesis.


The arrangement of ribosomes in ribosome tetramers from hypothermic chick embryos. 1. Ribosomes and the tetramer arrangement peculiar to the tissues of chick embryos exposed to low temperatures were separated by sucrose-density-gradient centrifugation, and the effects of variation of the concentrations of Mg(2+), Ca(2+) and K(+) studied. 2. Lowering of the Mg(2+) concentration from standard buffer conditions caused a reversible dissociation of tetramers into monomers and of these into subunits. 3. Ca(2+) replaced Mg(2+) in causing the re-formation of tetramers and monomers from subunits after dissociation in low Mg(2+) concentrations. 4. Ca(2+) also caused an almost complete conversion of monomers into dimers in the presence of Mg(2+). 5. The effect of Ca(2+) on the formation of dimers was abolished by pretreatment of the ribosomes with ribonuclease, but the re-formation of tetramers was unaffected. 6. Increase of the K(+) concentration from that of the standard buffer caused dissociation of monomers and dimers into subunits. 7. Raised K(+) concentration also caused a stepwise alteration of the tetramer from a particle with a sedimentation coefficient of 197S, which constitutes the bulk of the tetramer at low K(+) concentrations, first to a 184S peak and finally to material with a sedimentation coefficient of about 155S. 8. The implications of these results on hypotheses of the arrangement of the individual monomers in the tetramer are discussed and a new model for the structure is proposed.


Metabolism of camphanediols.

Metabolism of camphanediols. 1. The metabolism of the camphane-2,3-diols and camphane was investigated in rabbits. All the compounds increased the content of glucuronide in the urine. 2. Both trans- and cis-diols gave rise to ketols; the cis-diols gave rise to trans-diols, but not vice versa; camphorquinone gave cis-diol, ketols and trans-diol; camphane did not give rise to diols. 3. The possibility is discussed that an enediol is the intermediate for ketol interconversions in the present series of compounds and in other series such as hydroxyoestrones and hydroxyindanones.


Preparation of D-glycerate 3-O-sulphate, DL- glycerate 3( 35 S)-O-sulphate and D-glucose 6-O-sulphate.


Haem synthesis during mitochondrogenesis in yeast. The activities of delta-aminolaevulate synthetase and delta-aminolaevulate dehydratase have been assayed in Saccharomyces cerevisiae during glucose repression and de-repression. delta-Aminolaevulate dehydratase increased concomitantly with the increase in oxygen uptake during the de-repression phase caused by the depletion of glucose in the medium. delta-Aminolaevulate synthetase showed an oscillatory behaviour and a spurt in its activity always preceded the increase in oxygen uptake. The activity of both the enzymes was lowered if the cells were incubated with glucose or cycloheximide, but not with chloramphenicol.


Sulphur utilization during growth of pseudomonas fluorescens on potassium D-glucose 6-O-sulphate. Pseudomonas fluorescens N.C.I.B. 8248 was adapted to grow on potassium d-glucose 6-O-sulphate as the sole carbon and sulphur source. Adapted bacteria grew optimally at 37 degrees C on 1.6% (w/v) sulphate ester and growth coincided with the disappearance of the ester from the culture medium at a rate of 2.4mg/h per ml. Three sulphated compounds were detected in the culture fluid at the termination of growth. One of these was present in traces only and has not been identified. The second was present in somewhat greater amounts and was identified as the 6-O-sulphate ester of d-gluconate, and the major metabolite was identified as d-glycerate 3-O-sulphate. Sulphur utilization by the organism was not associated with the appearance of a glycosulphatase enzyme in the cells. However, a novel enzyme system (or systems) was present that liberated inorganic (35)SO(4) (2-) ions from dipotassium d-gluconate 6[(35)S]-O-sulphate and from dipotassium dl-glycerate 3[(35)S]-O-sulphate. Activity towards the latter substrate could not be detected when the adapted or parent Pseudomonas strain was cultured on d-glucose and potassium sulphate as respective carbon and sulphur sources. Some properties of the enzyme acting on the glycerate ester are recorded.


Studies on the composition of egg-white ovomucin. 1. Purified ovomucin was isolated as an insoluble glycoprotein complex from thick egg white. 2. A homogeneous glycoprotein, designated alpha-ovomucin, of molecular weight 210000 and containing N-acetylglucosamine (6.7%, w/w), N-acetylgalactosamine (0.6%, w/w), galactose (1.8%, w/w), mannose (4.6%, w/w), N-acetylneuraminic acid (1.0%, w/w) and sulphate (0.7%, w/w), was isolated from preparations of reduced ovomucin by sedimentation equilibrium in a density gradient of caesium chloride formed in the presence of 4m-guanidine hydrochloride. 3. A carbohydrate-rich fraction, designated beta-ovomucin (which is homogeneous by sedimentation-velocity analysis in 5m-guanidine hydrochloride but which is heterogeneous by analytical sedimentation equilibrium in a density gradient of caesium chloride in the presence of 4m-guanidine hydrochloride), containing N-acetylglucosamine (11.0%, w/w), N-acetylgalactosamine (8.7%, w/w), galactose (19.2%, w/w), mannose (4.1%, w/w), N-acetylneuraminic acid (13.8%, w/w) and sulphate (2.7%, w/w), was also obtained from preparations of reduced ovomucin by the density-gradient method. 4. Mild acid hydrolysis of the unfractionated ovomucin complex showed that N-acetylneuraminic acid occupied a terminal position of the oligosaccharide chains. 5. Alkaline beta-elimination reactions with the unfractionated ovomucin complex indicated that N-acetylgalactosamine was linked by alkali-labile bonds to hydroxy amino acids.


The computed distribution of copper(II) and zinc(II) ions among seventeen amino acids present in human blood plasma. The equilibrium distribution of copper(II) and zinc(II) ions among a mixture of 17 amino acids has been computed from stability-constant and blood-plasma-composition data. At pH7.4, 98% of the copper(II) in the simulated plasma solution is co-ordinated to histidine and cystine, predominantly as the mixed-ligand complexes [Cu.His.Cystine](-) and [Cu.H.His.Cystine]. Approximately half of the zinc(II) is co-ordinated to cysteine and histidine, but appreciable complex-formation occurs with most of the other amino acids. Stability constants are given for copper(II) and zinc(II) amino acid complexes, including some mixed-ligand species, at 37 degrees C and I=0.15m.


Rapid-sweep polarography of cystine.

Rapid-sweep polarography of cystine.


A new type of reagent for the detection of molecular varieties of some hydrolytic enzymes: detection of  -amylase isoenzymes.


Carlens endobronchial catheter versus regular endotracheal tube during thoracic surgery: a comparison of blood gas tensions and pulmonary shunting.


Effects of different oxygen concentrations during general anaesthesia for elective caesarean section.


Ketamine for dilatation and curettage.

Ketamine for dilatation and curettage.


Plasma levels of antidiuretic hormone in man during halothane anaesthesia and surgery.


The electroencephalogram and the site of action of pentazocine on the brain.


Hyperbaric treatment of cerebral air embolism: a report of a case following cardiac catheterization.


Fatal complication of subclavian catheter.


Intensive care in the neurosurgical unit.


An inexpensive thermistor temperature monitor.


Endotracheal intubation for 31 days in a tetanus patient.


Incorporation of Na-1- 14 C-acetate into the fatty acids of two insect parasites (Hymenoptera) reared on different hosts.


Attempts at chemotherapy of echinococcus multilocularis infections in rodents. II. A study of some parasiticides and cytostatic agents.


Observations on parasite-host relationships of Echinococcus multilocularis Leuckart, 1863, in North Dakota.


Neurosecretion and water balance in Cenocorixa bifida (Hung.) (Hemiptera, Corixidae).


The salivary glands of Aedes aegypti (L.): an electron microscope study.


The postembryonic development of the indirect flight muscles in Oncopeltus fasciatus (Dallas) (Hemiptera: Lygaeidae).


The postembryonic development of the indirect flight muscles in Cenocorixa bifida (Hung.) (Hemiptera: Corixidae).


The occurrence of Paruterina candelabraria (Goeze, 1782) and Cladotaenia globifera (Batsch, 1786) in Manitoba.


Dreams that precede a psychosomatic illness.


A clinical study of post-traumatic amnesia.


Object concept and object relations in childhood psychosis. A pilot study.


Psychotherapy supervision--a videotape technique.


A controlled study of the aversion relief treatment of phobias.


Capgras' syndrome. A case report.

Capgras' syndrome. A case report.


Sodium transfer to cerebrospinal fluid in functional psychiatric illness.


Clinical indications for transluminal dilatation in the management of atheromatous leg ischemia.


Aortic and peripheral arterial aneurysms.


The arteriospastic diseases: clinical significance and management.


Dissecting aortic aneurysm.

Dissecting aortic aneurysm.


Sudden arterial occlusion: medical aspects.


Sudden arterial occlusion: surgical aspects.


Medical management of extracranial vascular disease: indications and results.


Instrumental methods for studying the peripheral arterial circulation.


A digital rheoplethysmographic study of the vasomotor response to 'simulated diving' in man.


Venous thromboembolism.

Venous thromboembolism.


Lymphedema: recognition and management.

Lymphedema: recognition and management.


Use and abuse of direct current shock.

Use and abuse of direct current shock.


Intermittent claudication.

Intermittent claudication.


The natural history of arteriosclerosis obliterans.


Influence of the respiratory cycle on the configuration of the heart and vessels in the chest x-rays of children.


Arteriosclerosis obliterans in the lower extremities: correlation of clinical and angiographic findings.


Medical management of chronic occlusive arterial disease of the extremities.


Studies on transplantation immunity. II. The effect of different routes of sensitisation upon the response to allogeneic  51 Cr-labeled lymphoid cells.


Cytotoxin(s) produced by human lymphocytes: inhibition by anti-inflammatory steroids and anti-malarial drugs.


Cell recognition: reactions of the sea star (Asterias vulgaris) to the injection of amebocytes of sea urchin (Arbacia punctulata).


Interspecies differences in the inhibitory effect of ouabain on lymphocyte transformation.


The esophagogastric sphincter.

The esophagogastric sphincter.


Coordination of college and hospital respiratory therapy educational programs.


Coronary embolism in patients with mitral valve prosthesis.


Clinical evaluation of persons positive to stabilized tuberculin but negative to nonstabilized tuberculin.


Angiographic method for volume estimation of right and left ventricles.


Chalasia, peptic esophagitis, and hiatal hernia. A common syndrome in patients with central nervous system disease.


Acoustic, mechanical and electric alternans in hemopericardium of occult leukemic origin.


Negatively charged aerosols. Effect on pulmonary clearance of inhaled  239 PuO 2  in rats.


Roentgenogram of the month: pulmonic stenosis, chronic heart failure and cardiopericardial calcification.


The friction rubs of pericarditis.

The friction rubs of pericarditis.


Malignant tumor of the trachea.

Malignant tumor of the trachea.


Functional and transient trifascicular block due to aberrant premature atrial beats in a normal adult.


Intermittent left posterior hemiblock.

Intermittent left posterior hemiblock.


Suppression by a prominent T-wave: an unusual cause of malfunction of a transvenous demand pacemaker.


Calcification in chickenpox pneumonia.

Calcification in chickenpox pneumonia.


Intrathoracic lipomas.

Intrathoracic lipomas.


Pacemaker-induced supernormal atrioventricular conduction.


Traction-induced fracture of a central venous pressure catheter.


Deaths from subclavian vein catheterization.


The subunit structures and the molecular basis of the multiple hemoglobins of two species of trout, Salmo gairdneri and S. clarki clarki.


Comparative studies on the blood of monotremes and marsupials. I. Haematology.


The distribution of acid phosphatase in the Tasmanian devil, Sarcophilus harrisii (Marsupialia; Dasyuridae).


Biochemical properties of the blood of three equines.


Adolescent maternity services: a team approach.


Phosphoglucomutase polymorphism in pacific ocean perch, Sebastodes alutus.


Influence of chicken and rat plasma on in vitro activity of chicken and beef insulin.


Parallel temperature-induced changes in membrane fatty acids and in the transport of amino acids by the intestine of goldfish (Carassius auratus L.).


Liver serine dehydratase levels in the developing rat.


Caring for children with sickle cell anemia.


The presence of high ornithine-urea cycle enzyme activity in the teleost Opsanus tau.


Comparative enzymology of molluscan enolases.


Progress in early diagnosis of sickle cell disease.


Reduction in ChE during shock avoidance learning in the cockroach CNS.


Urea biosynthesis and excretion in freshwater and marine elasmobranchs.


An usual form of acquired aphasia in children.


Head shape and size of newborn infants.

Head shape and size of newborn infants.


Head shape and size of pre-term low-birthweight infants.


Developmental assessment of Jamaican infants.


A new graphic method for the evaluation of sexual maturity in girls.


The evolution of the EEG in two patients with maple syrup urine disease (branched-chained ketonuria).


Bilateral thrombosis of the middle cerebral artery in a child aged 14 months.


An unusual inheritane pattern for spinal muscular atrophy.


Vein of Galen malformation with atypical manifestations: a case report.


Operant procedures to eliminate drooling behavior in a cerebral palsied adolescent.


The future of the cerebral palsied child.


Heart-rate variability in a group of cerebral palsied children.


Shufflers with spastic diplegic cerebral palsy: a confusing clinical picture.


A pneumoencephalographic demonstration of brain atrophy following status epilepticus.


The relation of trophic influences to diseases of muscle.


Chromatin-positive Klinefelter's syndrome in children.


'Low-pressure hydrocephalus'.

'Low-pressure hydrocephalus'.


The classification of mental deficits.

The classification of mental deficits.


Neurological disease among hospitalised children.


Disturbed children under reduced auditory input: a pilot study.


Effectiveness of individualized instruction for kindergarten children with a developmental lag.


The hyperactive child in elementary school: a 5 year, controlled, followup.


Color discriminability for partially seeing children.


Incentives affecting behavior changes in the retarded.


Teacher observations on using ear protectors for disturbed children.


Modification of teachers' attitudes toward exceptional children.


Effects of perceptual-motor training on the educable mentally retarded.


Hippocampal control of behavioral arousal: duration of lesion effects and possible interactions with recovery after frontal cortical damage.


Recovery following sensorimotor cortical damage: evoked potentials, brain stimulation and motor control.


Energy reserves and chemical changes in denervated anterior and posterior latissimus dorsi muscles of the chicken.


Pattern discrimination in monocularly reared cats.


Amygdala unit activity during sleep and waking.


Electron microscope study of mouse cerebellum in tissue culture.


Dorsal column contributions to motor behavior.


Comments on "radiation quantities and their significane in health physics-- 1 and 2".


Denigration and sensorimotor disability induced by ventral tegmental injection of 6-hydroxy-dopamine in the cat.


Mobile CCUs.

Mobile CCUs.


Computers in medicine.

Computers in medicine.


Sampling techniques.

Sampling techniques.


Operating room environment.

Operating room environment.


The president-elect of the American Hospital Association discusses some of the trends that he sees in the delivery of health care.


Electrical shock hazards. 1.

Electrical shock hazards. 1.


Menu planning for the geriatric patient.


Combination telephone systems.

Combination telephone systems.


Nursing: automated proficiency reports.

Nursing: automated proficiency reports.


Liability for contaminated blood.

Liability for contaminated blood.


Variables influencing ovarian cycles in postpartum dairy cows.


Effect of pretreating heifers with human chorionic gonadotropin and estradiol on subsequent in vitro luteal tissue progesterone biosynthesis. The use of in vivo treatments of human chorionic gonadotropin (HCG), estradiol, or HCG plus estradiol was investigated as a method to provide large amounts of LH-sensitive luteal tissue for more extensive in vitro studies.  HCG (total dose 11,000) treatments to heifers on Days 1 to 7 of the estrous cycle produced tissue that was senitive to LH added in vitro, but Day 11 corpora lutea of the heifers were only slightly larger than normal.  Total doses of 13,000 and 15,000 IU HCG increased the weight of the corpora by factors of 2 and 3, but reduced or abolished the LH response in vitro.  Treatment with 5000 IU HCG on either Day 8 or 9 did not substantially increase the weight of the corpora.  Basal Day 11 in vitro progesterone synthesis was high, probably due to the recent in vivo luteotrophic treatment.  However, the tissue was not capable of further stimulation with LH in vitro.  Pretreatment with HCG plus estradiol in 2 experiments resulted in tissues with poor in vitro LH sensitivity.  Pretreatment with 3 mg estradiol at 4, 6.5, or 12.5 hours before removal of the corpus on Day 11 also reduced the sensitivity of the tissue to LH IN vitro.  These data support the theory that in vivo luteotrophic treatment may deplete a preformed precursor of progesterone, which reduces or abolishes LG sensitivity in vitro.  However, results obtained when estradiol was given at levels and times used in these experiments did not support the idea that estradiol reduces endogenous gonadotropins.


Effect of fasting, gestation, lactation and exercise on glucose turnover in horses.


Drylot feeding patterns for the reproducing beef cow.


Reproductive steroids in the bovine. VII. Changes postpartum.


Effects of added urea and ammonium polyphosphate to corn stover silages on animal performance.


Effects of cyclophosphamide in rams.

Effects of cyclophosphamide in rams.


Performance of two lines of Hereford cattle in two environments.


Certain aspects on the utilization of carbohydrates by the neonatal pig.


Digestion coefficients, blood glucose levels and molar percentage of volatile acids in intestinal fluid of ponies fed varying forage-grain ratios.


Effects of corn selenium content and drying temperature and of supplemental vitamin E on growth, liver selenium and blood vitamin E content of chicks.


Binding of copper by certain milk proteins as measured by equilibrium dialysis.


Effect of dietary oleates on lymph lipids in the young bovine.


Responses of dairy calves to oral doses of aflatoxin.


Children's recall strategies in dichotic listening.


Evidence for competition and coordination between vocal and manual responses in preschool children.


The effects of visually represented cues on learning of linear function rules.


Methodological study of form constancy development.


The effects of the environment upon state cycles in the human newborn.


Visual and haptic cue utilization by preschool children: the recognition of visual and haptic stimuli presented separately and together.


The use of verbal mediation in the retarded as a function of developmental level and response availability.


A study of occupational brucellosis.

A study of occupational brucellosis.


Testicular torsion.

Testicular torsion.


Hypercalcaemia with sarcoidosis and hyperparathyroidism.


Drugs and their abuse. X. The misuse of drugs in postnatal women.


'Neither up nor down'.

'Neither up nor down'.


Review of 100 elderly surgical patients.


Pelvic pneumography.

Pelvic pneumography.


Pilonidal cyst.

Pilonidal cyst.


Unusual location of carcinoid.

Unusual location of carcinoid.


Gallop rhythm.

Gallop rhythm.


Maine's Hill-Burton program.

Maine's Hill-Burton program.


Acetylcholine and experimental brain injury.


Relative susceptibility of elements of the cerebral cortex to mechanical trauma in the rat.


Discography and myelography in acute injuries of the cervical spine.


Excision of pineal tumors.

Excision of pineal tumors.


Longitudinal myelotomy in the treatment of spasticity of the legs.


Circling and rotational automatisms in patients with frontotemporal cortical and subcortical lesions.


Ruptured intracranial aneurysms in the first two decades of life. A study of 58 patients.


Detailed anatomy of the intracranial portion of the trigeminal nerve.


Intracranial aneurysm on a persistent primitive trigeminal artery. Case report.


Chondroblastoma of the skull. Case report.


Intracerebral oligodendroglioma with metastatic involvement of the spinal cord. Case report.


Large leptomeningeal cyst of the brain. Case report.


Evaluation of the patient with chronic glomerulonephritis.


Diet therapy of uremia.

Diet therapy of uremia.


Corticosteroid and immunosuppressive therapy of idiopathic nephrotic syndrome.


Neighboring-group participation in carbohydrate chemistry. II. Neighboring-group participation of the N,N-diethylamido group in a nucleophilic displacement of a 5-tosylate.


A deoxyketose via two-carbon chain extension of mannose.


Anodic decarboxylation of glycidic acids.


Dimensions of trait preferences and personality type.


Attempted leadership in the leaderless group discussion as a function of motivation and ego involvement.


Response competition, recognition, and affect.


Validation of feeling, belief, and intention to act as three components of attitude and their contribution to prediction of contraceptive behavior.


Influence of future choice importance and arousal upon the halo effect.


Effect of leadership style on the performance of small classroom groups: a test of the contingency model.


The results of laminectomy in patients with incomplete spinal cord injuries.


Stability of spinal fractures and fracture dislocations.


Spinal cord trauma in children.

Spinal cord trauma in children.


Post-traumatic syringomyelia.

Post-traumatic syringomyelia.


Psycho-social aspects of sexuality in spinal cord injury patients.


Sexual function and dysreflexia.

Sexual function and dysreflexia.


Dilemmas of leadership in community mental health.


Depression, anxiety and hostility.

Depression, anxiety and hostility.


Supervision of the first-year psychiatric resident. II. Exploring meanings.


Social class and patients' perceptions of mental illness.


The adolescent inpatient: patterns of depersonification.


Patients' attitudes toward society.

Patients' attitudes toward society.


Clinical observations on parricide.

Clinical observations on parricide.


Exhibitionism: genesis, dynamics and treatment.


Demographic and mental status profiles. Patients with homicidal, assaultive, suicidal, persecutory and homosexual ideation. The Missouri Automated Standard System of Psychiatry.


The relevance of psychoactive agents to psychotherapy.


What we should know about X-ray intensifying screens.


Restructuring the education of radiologic technologists.


Academic cheating: a problem in perspective.


Lesson plans for a course in nursing procedures.


Complications of psychotropic medications in high dosage.


Paraplegic management in rural India.

Paraplegic management in rural India.


First national platform for elderly deaf.


Paint by mouth not by numbers.

Paint by mouth not by numbers.


The lodge program. A peer group treatment program for the rehabilitation of the chronic mental patient.


Research utilization in other lands.

Research utilization in other lands.


Mike Finlay: a new definition of winner.


The quadriplegic in a university setting.


Breaking workshop exit barriers.

Breaking workshop exit barriers.


MR institutionalizations cut by evaluations.


The biomedical engineer--the roles he can play.


Crystal structure of a naturally occurring dinucleoside monophosphate: uridylyl (3',5') adenosine hemihydrate. The crystal structure of uridylyl (3',5') adenosine hemihydrate has been analyzed by x-ray diffraction. The two independent molecules found in the asymmetric unit exhibit conformations that differ significantly from those found in double-helical RNA. The conformational information obtained from this analysis provides considerable insight into the possible conformations of nonhelical "loop" regions of transfer RNA, as well as single-stranded regions of nucleic acids in general.


Brain serotonin content: increase following ingestion of carbohydrate diet. In the rat, the injection of insulin or the consumption of carbohydrate causes sequential increases in the concentrations of tryptophan in the plasma and the brain and of serotonin in the brain. Serotonin-containing neurons may thus participate in systems whereby the rat brain integrates information about the metabolic state in its relation to control of homeostatis and behavior.


Limulus lateral eye: properties of receptor units in the unexcised eye. Single receptor units in the compound eye of the horseshoe crab were illuminated, and their impulse discharges were recorded without removing the eye from the animal. The receptors were spontaneously active in darkness and responded without saturation over a light intensity range of 10(10) to 1. When the eye was excised, the receptors did not discharge in darkness and had an intensity range of 10(5) to 1, as is usually found. Experiments show that these and other differences result from cutting off the blood supply to the eye when it is excised. In addition, the range and shape of the intensity characteristic suggest that more than one receptor mechanism encodes light intensity in this eye.


Unstirred water layers in intestine: rate determinant of fatty acid absorption from micellar solutions. Bile acid and fatty acid uptake from micellar solutions by intestinal cells fails to reflect the incremental free energy changes expected for permeation that is rate limited by cell membranes. However, altering the size of the diffulsing particle or the thickness of tle unstirred water layer does change uptake. These observations show that the unstirred water layer is rate limiting for intestinal absorption of lipids from micellar solutions.


Melanin pigmentation: an in vivo model for studies of melanosome kinetics within keratinocytes. The phagocytosis of latex beads by epidermal cells is proposed as a model for stludies on melanosome kinetics within the epidermis. Large latex beads (0.8 micrometer) are ingested singly, whereas, small beads (0.1 micrometer) are taken up in groups, results showing that the uptake mechanism depends on the size of thze indlividual particles. This size-dependency may explain the different distribution patterns of melanosomes and thus the differences of skin color in the Caucasoid and Negroid races.


Genetic polymorphisms in varied environments. Thirteen experimenital populationis of Drosophila willistoni were maintained in cages, in some of which the environments were relatively constant and in others varied. After 45 weeks, the populations were assayed by gel electrophoresis for polymorphisms at 22 protein loci. The average heterozygosity per individual and the average unmber of alleles per locus were higher in populations maintained in heterogeneous environments than in populations in more constant enviroments.


Formaldehyde and ammonia as precursors to prebiotic amino acids.


Stability in zoological nomenclature.

Stability in zoological nomenclature.


Sex differences in I.Q. pattern of children with congenital heart defects.


Multiple genotypes in individuals of Claytonia virginica.


Solubilization of H-2 histocompatibility antigens of the mouse by Triton X-100 and butanol.


Bile salt depletion in the runting syndrome.


Migration of lymph node cells during the primary immune response.


Decreased longevity of mice following thymectomy in adult life.


Occurrence of cytotoxic antibodies during pregnancy.


An acquired B antigen associated with Proteus vulgaris infection.


E red cell system in pigs: irregular genetic transmission.


The HL-A antigen, LND (=W15).

The HL-A antigen, LND (=W15).


Alterations of red blood cell osmotic fragility during storage of blood drawn on ACD solution.


Universality of anti-A and anti-B human isolysins.


Clinical reactions to cryoprecipitated factor VIII.


The preservation of laboratory panel cells.


Identification of further antigens on red cells and lymphocytes. Association of B g  b  with W17 (Te57) and B g  e  with W28 (Da15,Ba).


The Kell system studied with radioactively-labelled anti-K.


Observations on a haemagglutinin from the freshwater mussel Anodonta anatina.


Lifespan of preserved red cells.

Lifespan of preserved red cells.


A hematological study of snow, blue, and Canada geese.


Blood collection in the sea lion.

Blood collection in the sea lion.


Vaccination of porpoises (Tursiops truncatus) against Erysipelothrix rhusiopathiae infection.


Toxoplasmosis in captive saiga antelope.


The agglutinin response in sockeye salmon vaccinated intraperitoneally with a heat-killed preparation of the bacterium responsible for salmonid kidney disease.


Ultrastructure of the epiphyseal plate of the normal guinea pig.


Adrenergic innervation of the alimentary canal.


Vasomotor innervation in the hind limb muscles of the normal and 6-hydroxydopamine treated cat. A formol fluorescence, histochemical and fine structural study.


Myocardial infarction in subjects with normal coronary arteriograms.


Hemodynamics and evaluation for surgery of patients with complete transposition of the great arteries and ventricular septal defect.


Prognosis of transient atrioventricular conduction disturbances complicating open heart surgery for congenital heart defects.


Characteristics of ventricular recovery of defined by the vectorcardiographic T loop.


Cardiac catheterization during anticoagulant therapy.


Familial cardiomyopathy. A review of 11 families.


The Eisenmenger syndrome. A clinical and physiologic reappraisal.


Normal coronary arteriogram following myocardial infarction in a 17-year-old boy.


Myocardial infarction in the absence of coronary occlusion.


Transposition of the great arteries. I. Clarification or further confusion?


Left ventricular intramural fibroma.

Left ventricular intramural fibroma.


Transposition of the great arteries. II. Transposition clarified.


Feedback circuits in the control of stem cell differentiation.


Depressed tuberculin sensitivity in Darier's disease.


Pityriasis lichenoides et varioliformis acuta (Mucha-Habermann).


Necrotizing vasculitis (erythema elevatum diutinum).


Pemphigus vulgaris.

Pemphigus vulgaris.


Disseminate and recurrent infundibulo-folliculitis.


Cutaneous cryptococcosis. A sentinel of disseminated disease.


Acid-fast bacteria in scleroderma and morphea.


Transient acantholytic dermatosis. Electron microscope study.


Prolonged oral treatment of chronic mucocutaneous candidiasis with Amphotericin B.


CSF imaging (cisternography) in pediatric patients.


Ichthyosiform erythroderma, hair shaft abnormalities, and mental and growth retardation. A new recessive disorder.


Lichen planus pemphigoides with extensive melanosis. Occurrence in a patient with malignant lymphoma.


Increased protocollagen proline hydroxylase activity in sclerodermatous skin.


Lichen sclerosus et atrophicus involving the palms.


Hypomelanosis from an antioxidant in polyethylene film.


Allergic contact dermatitis from ragweeds (Ambrosia species). The role of sesquiterpene lactones.


Cutaneous stigmas of heroin addiction.

Cutaneous stigmas of heroin addiction.


Fixed eruption due to glutethimide.

Fixed eruption due to glutethimide.


Local changes at the site of pentazocine injection.


Buffered glutaraldehyde solution for warts.


Basal cell carcinoma at the base of cutaneous horn (cornu cutaneum).


Keratosis.

Keratosis.


Benign mucous membrane pemphigoid.

Benign mucous membrane pemphigoid.


Chromomycosis. Treatment with thiabendazole.


Efficacy of "dermatophyte test medium". Comparison of two commercial preparations with laboratory-prepared Sabouraud-antibiotic medium.


Junctional activity recurring over an incompletely removed balloon cell nevus.


Giant apocrine hidrocystoma.

Giant apocrine hidrocystoma.


Malignant hidroacanthoma simplex.

Malignant hidroacanthoma simplex.


Contact dermatitis to a plastic solvent in eyeglasses. Cross-sensitivity to ethyl acetate.


Atherothrombotic emboli in the lower extremities.


Lichen nitidus of the palms and soles.

Lichen nitidus of the palms and soles.


Toxoplasmosis. A complication of corticosteroid-and cyclophosphamide-treated lupus erythematosus.


Acid-fast bacteria in scleroderma.

Acid-fast bacteria in scleroderma.


Relationships of microorganisms to psoriasis--toxic or allergic?


Systemic lupus erythematosus, miliary tuberculosis, and bilateral herpes zoster occurring in a Chinese woman.


Hydroxyurea and macrocytosis.

Hydroxyurea and macrocytosis.


The Mobin-Uddin inferior vena caval filter.


Amebic perforation of the colon.

Amebic perforation of the colon.


Total hip replacement. First year's experience.


Ultrasonic arteriography.

Ultrasonic arteriography.


Percutaneous transhepatic cholangiography.


Complications in the application of the inferior vena cava umbrella technique.


Abdominal implants of strontium 90-Americium 241/beryllium sources. Stimulation of radiation fields from nuclear powered artifical hearts.


Potentiation between intestinal and gastric phases of acid secretion in Heidenhain pouches.


The effect of selective proximal vagotomy and pyloroplasty on gastric secretion and motility in the dog.


Experimental pancreatitis in pigs.

Experimental pancreatitis in pigs.


Importance of nutrition in the pathogenesis of experimental pancreatitis in the dog.


Serum enzymes in experimental ballistic injury to extremities.


Femoral-axillary bypass for cerebral vascular insufficiency.


Renal artery embolectomy.

Renal artery embolectomy.


The hand in Maffucci syndrome.

The hand in Maffucci syndrome.


Cancer following treatment of an autonomously functioning thyroid nodule with sodium iodide I-131.


Diospyrobezoar of the jejunum in a postgastrectomy patient.


The Doppler ultrasonic flowmeter in the management of the dialysis arteriovenous fistula.


Skin and subcutaneous metastases from gastrointestinal carcinoid tumors.


Mixtures of chlorphenamidine with other acaricides for the control of organ ophosphorus-resistant strains of cattle tick Boophilus microplus.


The influence on subsequent performance of time between the hatching of broiler chickens and their access to feed and water.


The formation of verdohaemochrome from pyridine ferrihaemochrome by boiled extracts of fish liver.


Effect of protein content of diet on lysine oxidation by the rat.


Formation of N-acetyl-L-alanine and N-acetylglycine from glucose by Candida tropicalis OH 23 .


The effect of cortisone on hexosamine metabolism in the rat.


Some effects of cholesterol on the metabolism of Pythium sp. PRL 2142.


Solid-phase method for peptide synthesis using macroreticular copolymers.


2-Aminoethylphosphonic acid: distribution in human tissues.


Chromosomal problems of intrauterine diagnosis.


Chelation of some bivalent metal ions by racemic and enantiomeric forms of tyrosine and tryptophan.


Problems in the use of cultured amniotic fluid cells for biochemical diagnoses.


Amniocentesis and abortion: methods and risks.


Psychosocial aspects of selective abortion.


Symposium on intrauterine diagnosis. Discussion of symposium papers.


Public health and long-term genetic implications of intrauterine diagnosis and selective abortion.


Symposium on intrauterine diagnosis; held at Indianapolis, Indiana, October 13 and 14, 1970. Introductory remarks.


Indications for amniocentesis in the early prenatal detection of genetic disorders.


Value of electrocardiogram in population surveys. An attempt to improve interpretation.


Incidence of acute rheumatic fever.

Incidence of acute rheumatic fever.


Systematization and embryological and anatomical study of mirror-image dextrocardias, dextroversions, and laevoversions.


Spontaneous closure of ventricular septal defect after banding of pulmonary artery.


Congenital coronary artery fistula. Analysis of 17 cases.


Clinical significance of the coronary arteriogram.


Electrocardiographic abnormalities during exercise 3 weeks to 18 months after anterior myocardial infarction.


Plasma glycerol concentration in patients with myocardial ischemia and arrhythmias.


Auscultatory and phonocardiographic findings in autologous fascia lata valves.


Clinical, electrocardiographic, and haemodynamic effects of long-term use of propranolol in Prinzmetal's variant angina pectoris.


Continuous murmur in pulmonary atresia with reference to aortography.


Simple method of evaluating vectorcardiographic loops in children.


Vectorcardiographic T loop analysis in ischaemic heart disease.


Treatment of chronic heart block with the Lucas induction coil pacemaker.


Reversion of ventricular tachycardia by pacemaker stimulation.


Hyperventilation test for diagnosis of left-to-right circulatory shunts.


Ventricular aneurysms after cardiac surgery.


Facilitation of conduction in left bundle of His.


Atrioventricular and associated intraventricular conduction disturbances in acute myocardial infarction.


Mitral valve replacement in a patient with severe respiratory insufficiency.


Bacterial endocarditis over prosthetic valves treated with trimethoprim-sulphamethoxazole combination.


Immunotolerance to insulin and Freund's adjuvant.


A gastric inhibitory polypeptide. II. The complete amino acid sequence.


Erythrocyte lipids of Atlantic cod, Gadus morhua.


The reaction of hemoglobin with the complex formed from haptoglobin and hemoglobin alpha-subunits.


Interaction of [4-14C]estradiol and its metabolites with polynucleotides in the presence of peroxidase.


An immunoglobulin light chain of subgroup III-1 of lambda type with a free sulfhydryl group.


Agents affecting lipid metabolism. XL. Effect of ethyl chlorophenoxyisobutyrate on liver lipids and serum lipoproteins in rats.


Studies on the biosynthesis of mitomycin C by Streptomyces verticillatus.


Cholesterol metabolism and vitamin B6. 3. The stimulation of hepatic cholesterogenesis in the vitamin B6-deficient rat.


An atypical substrate-inhibitor-rate relationbship for the action of antimycin A on the succinate-ferricyanide reductase activity of beef heart electron transfer particles.


Esterification of linoleate by rabbit reticulocytes.


Properties of a purified carnitine palmitoyltransferase, and evidence for the existence of other carnitine acyltransferases.


Preparation of methyl derivatives of some organic acids for analysis by gas-liquid chromatography.


Biosynthesis of furanochromones.

Biosynthesis of furanochromones.


DNA polymerases of newborn rat brain and liver.


Acetyl-CoA holocarboxylase synthetase of rat adipose tissue.


The effect of preganglionic stimulation on the acetylcholine and choline content of a sympathetic ganglion.


Supraesophageal ganglia influences on Limulus heart rhythm: confirmatory evidence.


The effects of cold and prostaglandin  E1  on lipid mobilization in the chicken.


The effect of added external resistance on regional pulmonary filling and emptying sequences.


The effect of ouabain on substrate metabolism in the isolated perfused rat heart.


Effects of bilateral vagotomy on renal function in the rat.


Fatty acid composition of carcass, heart, liver, and blood lipids in young lambs fed diets containing vegetable or animal fats.


Electrical resistance and volume flow in glass microelectrodes.


Factors affecting the inactivation of insulin-125-I by rat adipose tissue.


The effect of lidocaine on twitch potentiation and repetitive neural activity produced by soman and neostigmine.


A study of the renal excretion of calcium by the production of a constant level of hypercalcemia in normal and abnormal human subjects.


Inhibition of human platelet aggregation by a dibenzazepine compound (GP 44296) and by N-(2,6-dichlorophenyl)-o-aminophenylacetic acid (GP 45840).


The effect of acute ethanol administration on parathion toxicity and in vitro parathion degradation in the rat.


Perfusion of the anterior septal artery in the canine heart.


An eserine-like action of chloroquine.

An eserine-like action of chloroquine.


A simple quantitative procedure for the partition of free and esterified fatty acids from fecal lipids.


The role of nurses in the delivery of health care.


What are you doing about pollution?

What are you doing about pollution?


Setting up a free clinic for transient youth.


The seven-day fortnight.

The seven-day fortnight.


The dish--a gift of love.

The dish--a gift of love.


Glyoxalase activity in sham- and partially hepatectomized rats.


Some determinants of camptothecin responsiveness in leukemia L1210 cells.


Binding of estradiol-17-beta to human cancer tissue of the female genital tract.


Effect of pregnancy, lactation, and pituitary isografts on the genesis of spontaneous mammary gland tumors in the mouse.


Difference in effects of proflavine and actinomycin D on mammalian cell nucleoli.


Biological and biochemical differences between tubercidin (7-deazaadenosine) and its 5'-phosphate methyl ester.


Structure-activity relationships in DNA binding and nuclear effects of aflatoxin and anlogs.


Carcinogenicity of derivatives of 7,12-dimethylbenz(a)anthracene.


Effect of mammary tumor virus infection on in vivo oxidation of glucose-1-14C and glucose-6-14C in C3H mice.


Interference of daunomycin and adriamycin on the growth and aggression of murine sarcoma virus (Moloney) tumors in mice.


Acute ultrastructural effects of benzo[a]pyrene and ferric oxide the hamster tracheobronchial epithelium.


Alterations in morphology and growth pattern in a transplantable leukemia of rats.


Differences in the immunogenicity of leukemia L1210 sublines in DBA-2 mice.


Spontaneous regression of chemically induced malignant lymphoma in Swiss mice.


The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.


Statistical estimation of prognosis for children with neuroblastoma.


The ultrastructure of target L-cells and immune macrophages during their interaction in vivo.


Differential effects of melphalan on mouse myeloma (adj. PC-5) and hemopoietic stem cells.


Increase of leukemia L1210 immunogenicity by Vibrio cholerae neuraminidase treatment.


Ribosome monomers in rat liver following administration of dimethylnitrosamine.


Effect of culture media on self-organization and protein synthesis of neural retina cells.


Characterization of lactate dehydrogenase of Helisoma antrosum (Mollusca: basommatophora): enzyme assays, polyacrylamide-gel electrophoresis and isoelectric focusing.


Ammonia forming mechanisms: deamination of 5'-adenylic acid (AMP) by some polychaete annelids.


The lactic dehydrogenase activity of trypanosomes and platelets isolated from ray rat blood.


The transferrins and hemoglobins of wild Iranian sheep (Ovis linnaeus).


The transferrins and hemoglobins of bighorn sheep (Ovis canadensis), dall sheep (Ovis dalli) and mouflon (Ovis musimon).


The prehypnotic suggestion.

The prehypnotic suggestion.


Tropomyosin B from the African civet, Civettictis civetta.


Let us not confound the schizophrenic's family.


Effect of amphetamine or chlorpromazine on achievement strivings scores derived from content analysis of speech.


A conceptual outline for day treatment center practice.


Role of liaison psychiatrist in teaching medical students.


A perspective on self-esteem.

A perspective on self-esteem.


Distinguishing features of patients who discharge themselves from psychiatric ward.


The dysvascular amputee: surgery and rehabilitation.


Phenomenology: an alternative approach to diagnosis of mental disease.


Cephalic phase of insulin secretion in obese adolescents.


Evaluation of age-adjusted criteria for potential diabetes.


Diabetic retinopathy: new vessels arising from the optic disc. I. Grading system and natural history.


Diabetic retinopathy: new vessels arising from the optic disc. II. Response to pituitary ablation by yttrium 90 implant.


Glucagon and the insulin: glucagon ratio in diabetes and other catabolic illnesses.


Learning deficiency versus developmental conceptions of mental retardation.


A noncategorical consortium program.

A noncategorical consortium program.


A sociolinguistic approach to functional mental retardation.


Some aspects of transport and digestion in the lens of the normal young adult rat.


Sodium leakage in cattle rod outer segments.


The role of the epithelium in control of corneal hydration.


Properties of a ribonuclease inhibitor from bovine lens.


Effects of catecholamines on the ocular tension of normal and sympathetically denervated rabbit eyes.


Ultrastructural changes associated with loss of transparency in the primary spectacle and cornea of spawning sea lamprey.


Selective binding of aged alpha-crystallin to lens fibre ghosts.


Near ultraviolet light effects on dogfish retinal rods.


theoretical considerations on the mechanism of the aqueous outflow.


Fate of human lens soluble protein during cataractogenesis.


Retention of ascorbic acid by the guinea pig eye lens.


The effect of electrical stimulation of the ciliary nerves on systemic blood pressure.


Permeability of the lens capsule to tryptophan.


Lactate dehydrogenase (LDH) isoenzymes in the retina of the sheep and changes associated with progressive retinal degeneration (Bright Blindness).


Formation of giant cells in the corneal endothelium during its regeneration after destruction by freezing.


Regulation of hearing aid dealers.

Regulation of hearing aid dealers.


Dose-dependent influence of topically instilled adrenergic agents on intraocular pressure and outflow facility in the rabbit.


Outpatient cataract surgery.

Outpatient cataract surgery.


Physical diagnosis of temporal arteritis.


Television and the team approach to microsurgery.


Microangiopathy in diabetics with hearing disorders.


Preoperative thyroid scanning in children with neck masses.


A study of some physical criteria for the assessment of prematurity.


The effect of various biological factors on birth weight.


Management of the child with allergic asthma.


Antirachitic activity in sera of patients with vitamin-D deficiency rickets.


Cerebral palsy in children. A report of 50 cases.


Cystic meningioma in a child.

Cystic meningioma in a child.


Alterations in serum lactate dehydrogenase activity and its isoenzyme pattern after massage of the prostate. Value in differentiating carcinoma from benign hyperplasia of the prostate.


The Riker method for determining formaldehyde in the presence of methenamine.


Total replacement of the ureter with a bladder flap.


The significance of the renal pelvis and intrarenal veins in renal lymph formation.


Serum enzymes after experimental acute renal infarction.


In vitro maintenance of human hyperplastic prostate tissue.


Ultrastructural and biochemical study of neuroblastoma and ganglioneuroblastoma.


The effect of vesicoureteral reflux on renal growth and development in puppies.


Comparison of reactivity of leached versus dipped latex surgical materials in laboratory rats.


The kinematic anatomy of skeletal muscle fibres. 1. Basic principles and swing muscles.


A plea for the routine use of operative cholangiography at cholecystectomy.


Adenocarcinoma of the uterine body following use of intrauterine contraceptive device.


Effect of frusemide on serum calcium.

Effect of frusemide on serum calcium.


President's address. The promise of action.


The right to health security through health reform.


Effects of a piperazine-carbon disulfide-phenothiazine preparation on hemoglobin and packed cell values of horses.


Effect of porosity of heterogeneous poly(glycol monomethacrylate) gels on the healing-in of test implants.


Perm-selective dialysis membranes. I. Films based on dimethylaminoethyl methacrylate copolymers.


Permeability studies with cellulosic membranes.


The pressure dependence of the elastic constants of dental amalgam.


The elastic constants of the constituent phases of dental amalgam.


A composite model of the elastic behavior of dental amalgam.


Resistance of erythrocytes of hibernating mammals to loss of potassium during hibernation and during cold storage. In two species of hibernators, hamsters and ground squirrels, erythrocytes were collected by heart puncture and the K content of the cells of hibernating individuals was compared with that of awake individuals. The K concentration of hamsters did not decline significantly during each bout of hibernation (maximum period of 5 days) but in long-term bouts in ground squirrels (i.e. more than 5 days) the K concentration of cells dropped significantly. When ground squirrels were allowed to rewarm the K content of cells rose toward normal values within a few hours. Erythrocytes of both hamsters and ground squirrels lose K more slowly than those of guinea pigs (nonhibernators) when stored in vitro for up to 10 days at 5 degrees C. In ground squirrels the rate of loss of K during storage is the same as in vivo during hibernation, and stored cells taken from hibernating ground squirrels also lose K at the same rate. The rate of loss of K from guinea pig cells corresponded with that predicted from passive diffusion unopposed by transport. The actual rate of loss of K from ground squirrel cells was slower than such a predicted rate but corresponded with it when glucose was omitted from the storage medium or ouabain was added to it. Despite the slight loss of K that may occur in hibernation, therefore, the cells of hibernators are more cold adapted than those of a nonhibernating mammal, and this adaptation depends in part upon active transport.


Temperature adaptation of active sodium-potassium transport and of passive permeability in erythrocytes of ground squirrels. Unidirectional active and passive fluxes of (42)K and (24)Na were measured in red blood cells of ground squirrels (hibernators) and guinea pigs (nonhibernators). As temperature is lowered, "active" (ouabain-sensitive) K influx and Na efflux were more greatly diminished in guinea pig cells than in those of ground squirrels. The fraction of total K influx which is ouabain sensitive in red blood cells of ground squirrels was virtually constant at all temperatures, whereas it decreased abruptly in guinea pig cells as temperature was lowered. All the passive fluxes (i.e., Na influx, K efflux, and ouabain-insensitive K influx and Na efflux) decreased logarithmically with decrease in temperature in both species, but in ground squirrels the temperature dependence (Q(10) 2.5-3.0) was greater than in guinea pig (Q(10) 1.6-1.9). Thus, red blood cells of ground squirrel are able to resist loss of K and gain of Na at low temperature both because of relatively greater Na-K transport (than in cells of nonhibernators) and because of reduced passive leakage of ions.


The interaction between steroid hormones and lipid monolayers on water. The interaction of progesterone, testosterone, androsterone, and etiocholanolone with insoluble lipid films (cholesterol and saturated hydrocarbons containing either alcohol, ester, acetamide, phosphate, amine, or carboxyl groups) was studied. In addition to surface pressure and surface potential measurements of the surface films, radioactive tracers were used to measure the concentration of adsorbed steroid in the lipid films. In general, steroids form mixed films with the insoluble lipid films. Compression of the insoluble lipid films to their most condensed state leads to complete ejection of adsorbed steroid from the surface in all cases except with the amine, for which a small amount of steroid is still retained in the surface. Interactions between the steroids and insoluble lipids are primarily due to van der Waals or dispersion forces; there were no significant contributions from dipole-dipole interactions (except possibly with the amine). Specific interactions between cholesterol and the soluble steroids were not observed. Evidence suggests that low steroid concentrations influence structure of lipid films by altering the hydration layer in the surface film. In contrast to a specific site of action, it is proposed that steroid hormones initiate structural changes in a variety of biological sites; this model of steroid action is consistent with the ubiquity of many steroid hormones.


Conductance change associated with receptor potentials of gustatory cells in rat. The electrical properties of gustatory cells and cells which do not respond to chemical stimuli in the taste bud of fungiform papillae in rats were studied by means of intracellular microelectrodes. Neither of these cell types showed spike electrogenesis. Gustatory cells showed a depolarization, the receptor potential, associated with an increase in the membrane conductance in response to NaCl, sucrose, and HCl, whereas quinine produced a decrease in the conductance together with an increase in the receptor potential magnitude. The reversal point of the receptor potential in response to NaCl or KCl was close to zero membrane potential, but in the case of quinine it was at a more negative potential level than the resting potential. From these results two receptive processes are postulated in the gustatory cell membrane. When the gustatory cells were stimulated for a long duration by concentrated NaCl or sucrose, receptor potentials showed adaptation with decrease in magnitude, but adaptation of the responses to HCl and quinine were hardly detected. Adaptation of the receptor potential was not correlated with conductance change.


The radial variation of potential in the transverse tubular system of skeletal muscle.


Divalent ions and the surface potential of charged phospholipid membranes. Phospholipid bilayer membranes were bathed in a decimolar solution of monovalent ions, and the conductance produced by neutral carriers of these monovalent cations and anions was used to assess the electric potential at the surface of the membrane. When the bilayers were formed from a neutral lipid, phosphatidylethanolamine, the addition of alkaline earth cations produced no detectable surface potential, indicating that little or no binding occurs to the polar head group with these ions. When the bilayers were formed from a negatively charged lipid, phosphatidylserine, the addition of Sr and Ba decreased the magnitude of the surface potential as predicted by the theory of the diffuse double layer. In particular, the potential decreased 27 mv for a 10-fold increase in concentration in the millimolar-decimolar range. A 10-fold increase in the Ca or Mg concentration also produced a 27 mv decrease in potential in this region, which was again due to screening, but it was necessary to invoke some specific binding to account for the observation that these cations were effective at a lower concentration than Ba or Sr. It is suggested that the ability of the alkaline earth cations to shift the conductance-voltage curves of a nerve along the voltage axis by 20-26 mv for a 10-fold increase in concentration may be due to essentially a screening rather than a binding phenomenon.


The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.


The immunologic release of constituents from neutrophil leukocytes. II. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces.


Role of basophilic leukocytes in cellular immunity to vaccinia virus infection.


Latent measles virus infection of the hamster central nervous system.


The effect of excision of the site of application on the induction of delayed contact sensitivity.


Isolation of the anticomplementary protein from cobra venom and its mode of action on C3.


The DNA synthetic response of adoptively transferred thymocytes in the spleens of lethally irradiated mice. I. Effects of varying antigen and thymocyte doses.


Immune adherence reactions of human erythrocytes sensitized with complement in vitro and in vivo.


Amino terminal sequences of heavy and light chains of chicken anti-dinitrophenyl antibody.


Noncovalent interaction between immunoglobulin (Ig) polypeptide chains. II. Absence of hybrid molecule formation between Ig Classes.


A polypeptide chain from leopard shark 19S immunoglobulin analogous to mammalian J chain.


Lymphoproliferative cycles in the thymus cortex.


An epidemiologic test of the "spectrum of disease" concept in cervical neoplasia.


Functional capacity of bone marrow modified by contact with antigenic substances.


Hyperplastic and inflammatory nodules in the canine mammary gland.


Demonstration of cellular immunity against urethan-induced lung adenomas of mice.


Occurrence of tumors in domestic animals. Data from 12 United States and Canadian colleges of veterinary medicine.


Role of interferon in the protective effect of the double-stranded polyribonucleotide against murine tumors induced by Moloney sarcoma virus.


Megakaryocyte quantitation after reticuloendothelial system blockade with carbon.


The effect of metabolic inhibitors on the migration of guinea pig macrophages.


Enhancement of metastases by L-asparaginase in a mouse tumor system.


New directions for wastewater collection and disposal.


Kinetic studies of macrophages. I. Distributional characteristics of radiolabeled peritoneal cells.


The economic feasibility of treating textile wastes in municipal systems.


Rotating disks with biological growths prepare wastewater for disposal or reuse.


Evaluation criteria for granular activated carbons.


Use of polyelectrolytes in treatment of combined meat-packing and domestic wastes.


Effluent quality control at a large oil refinery.


Treatment of cold-mill wastewater by ultra-high-rate filtration.


Forms of organic nitrogen in domestic wastewater.


Hydrogen isotope ratios in a recycling system.


Treatment of wastes from a sole leather tannery.


Life style and disease.

Life style and disease.


Health in the Western Pacific, 1970-1971.


Cereborvascular disease occurrence in Australia.


The prevalence of wheezing and other respiratory symptoms in schoolchildren aged six to eleven years from Perth, Western Australia.


Postoperative management of a narcotic addict.


War liver trauma.

War liver trauma.


Therapeutics--a neglected speciality?

Therapeutics--a neglected speciality?


Australian pharmacology--a suitable case for treatment.


Clinical pharmacology in New Zealand.

Clinical pharmacology in New Zealand.


Teaching practical classes in clinical pharmacology.


Methaqualone: efficacy as a hypnotic and side effects.


Possible allergic skin reaction to Michel clips.


Transferable drug resistance.

Transferable drug resistance.


Tobispray.

Tobispray.


National Health Service.

National Health Service.


General practice.

General practice.


Sigmoid myotomy for diverticular disease of the colon.


Diagnostic aids in the treatment of pancreatic disease.


Surgical treatment of oesophageal hiatus hernia.


Prognosis of cancer of the breast.

Prognosis of cancer of the breast.


Management of deep vein thrombosis.

Management of deep vein thrombosis.


Diagnosis and management of pulmonary embolus.


Arterial embolectomy and venous thrombectomy.


Treatment of shock. News New concepts and old shibboleths.


Management of dissecting aneurysms.

Management of dissecting aneurysms.


Surgical treatment of coronary artery disease.


REcurrent swelling of the parotid gland (recurrent parotitis).


Topical use of 5-fluorouracil cream for skin cancer.


MAlignant tumours of the paranasal sinuses with emphasis on primary surgical resection.


Current trends in surgery for peptic ulcer.


Radiotherapy of oesophageal cancer.

Radiotherapy of oesophageal cancer.


Results of treatment of carcinoma of the colon and rectum.


Rectal prolapse.

Rectal prolapse.


Chronic atrial pacing to control paroxysmal junctional tachycardia.


Ocular hazards of visible light.

Ocular hazards of visible light.


Notes on digestive diseases. I. Duodenal ulcer.


Simplified technique in submental lipectomy.


Trial of a sternoclavicular whole joint graft as a substitute for the temporomandibular joint.


One-stage reconstruction of the lacrimal apparatus.


Malignant degeneration of basal cell carcinomas of the face; basal-squamous carcinoma.


Excerpts from chairman's address to the American Board of Plastic Surgery.


Successful replantation of a traumatically amputated glans penis. Case report.


The addition of adhesive backing to nasal splints.


Congenital nasal tip retrusion and three little composite ear grafts. Case report.


Crossed-denuded flap as a complement to the Millard technique in the correction of cleft lip.


Solute aberrations in traumatic shock.

Solute aberrations in traumatic shock.


Nutrition, the red cell and burns.

Nutrition, the red cell and burns.


[Hodgkin's disease: response of lymphocytes to PHA].


A two-stage liver resection combined with longterm intraportal 5-FU infusion.


The new biology: what price relieving man's estate?