Crohn's disease. A clinical study based on 186 patients.


Effect of a duodenal tube on the gastric secretion of acid and pepsin in man.


Uptake of radioactive strontium (SR-85) in an inflamed mastoid process.


Recent trials in the treatment of maxillary sinus carcinoma, with special reference to the chemical potentiation of radiation therapy.


An enquiry on the morphological characteristics and possible changes with age in the olfactory region of man.


Continuous norethindrone, 0.35 mg., as an oral contraceptive agent.


Antifertility effects of intrauterine progesterone in the rabbit.


The effect of human chorionic gonadotropin on castrated postmenopausal women.


Gonadoblastoma occurring in a female with XO-XY fragment gonadal dysgenesis.


Treatment of vulvar dystrophies with topical testosterone propionate.


Gonadotropin-inhibiting factor in pregnancy, lactation, and menopause.


Effects of maternal hyperoxia on the fetus. I. Oxygen tension.


Intravascular coagulation in abruptio placentae.


Correlation of gestational age with maternal human chorionic somatomammotropin and maternal and fetal growth hormone plasma concentrations during labor.


Primary carcinoma of the cervix appearing in immunosuppressed renal transplant recipient.


Calcium carbonate deposition on intrauterine contraceptive devices.


The prevalence of chronic bronchitis, chronic airway obstruction, and respiratory symptoms in a Colorado city.


Serum IgA deficiency in a man with desquamative interstitial pneumonia.


Disseminated nodular pulmonary ossification in the Hamman-Rich lung.


Rib cage and abdomen-diaphragm in bronchial asthma: relative contributions to air displacement.


Nebulization of amphotericin B.

Nebulization of amphotericin B.


Muscle surface pH as an index of peripheral perfusion in man.


Subclavian vein catheterizations: a prospective study. I. Non-infectious complications.


Periodic variation in the antibacterial function of human neutrophils and its relationship to sepsis.


Influence of ambient temperature on patient temperature during intraabdominal surgery.


Rectal reaction following radiation therapy of cervical carcinoma: particular reference to subsequent occurrence of rectal carcinoma.


Carcinoma of the male breast.

Carcinoma of the male breast.


Sweat gland carcinoma: a clinico-pathologic study of 83 patients.


Wilkie's syndrome.

Wilkie's syndrome.


Severe ischemia of the hand.

Severe ischemia of the hand.


Blood lactate in the prognosis of various forms of shock.


Bilateral diaphragmatic hernia from blunt injury causing a Budd-Chiari syndrome: use of liver and spleen scan in demonstrating the defects.


Median arcuate ligament compression of the celiac and superior mesenteric arteries.


Urinary excretion of DDA following ingestion of DDT and DDT metabolites in man.


Wind flow and respiratory mortality in Los Angeles.


Chrysotile asbestos in the lungs of persons in New York City.


Chromosome studies in workers exposed to benzene or toluene or both.


Sulfur dioxide: Sulfite. Interaction with mammalian serum and plasma.


Comment on toxic substances and DDT.

Comment on toxic substances and DDT.


Seizures and recurrent subarachnoid hemorrhage due to a cryptic vascular malformation.


Ataxia-telangiectasia: report of a case.


Neuroclinical-pathology conference.

Neuroclinical-pathology conference.


Interaction of hemoglobin with ions. Binding of ATP to human hemoglobin under simulated in vivo conditions.


Bovine erythrocyte cupro-zinc protein. 1. Isolation and general characterization.


Bovine erythrocyte cupro-zinc protein. 2. Physicochemical properties and circular dichroism.


Curvilinearity between dream content and death anxiety and the relationship of death anxiety to repression-sensitization.


Effect of pretherapy information on learning in psychotherapy.


Reinforcing values of interpretations and reflections in a quasi-therapeutic interview.


Mental illness and the ipact of believing others know about it.


Social influence and counterinfluence within families of four types of disturbed adolescents.


Role of attentional focus in pain perception: manipulation of response to noxious stimulation by instructions.


Discrimination learning in juvenile delinquents.


The A-B scale and empathy, warmth, genuineness, and depth of self-exploration.


Response to cutaneous pain in mental hospital patients.


Verbal-nonverbal conflict in parental messages to normal and disturbed children.


Relationship of familial and social factors to socialization in middle-class college students.


Conceptual shifting in chronic alcoholics.


ECS disruption of time-dependent processes in discriminated-avoidance conditioning in rats: incubation or consolidation?


Population differences and learning proficiency.


Sentence structure and retention in good and poor readers.


Weber in the classroom.

Weber in the classroom.


Perceptual attenuation of an irrelevant auditory verbal input as measured by an involuntary verbal response in a selective-attention task.


Identification, organization, and reading comprehension for good and poor readers.


Perceptual-motor performance under rotation of the central field.


The impact of surgical diseases on an Appalachian community.


Hemorrhage. A persistent source of obstetrical emergency.


Potassium-losing nephropathy of childhood.


Cholera: an imported case in Australia, 1969.


A spear in the brain.

A spear in the brain.


Envenomation by the Australian common brown snake--Pseudonaja (Demansia) textilis textilis.


Monitoring value of serial chest x-ray examinations with portable equipment.


Outlook in childhood leukaemia.

Outlook in childhood leukaemia.


The increase in venereal disease.

The increase in venereal disease.


Analgesic nephropathy. Changes in various parameters of renal function following cessation of analgesic abuse.


Home dialysis in Victoria.

Home dialysis in Victoria.


The nephrotic syndrome of quartan malaria.


Aneurysmal bone cysts penetrating the tibial epiphysis after curettage.


Haemangioendothelial sarcoma of the liver.


Ball variance complicating prosthetic replacement of the aortic valve.


Carcinoma of the thyroid.

Carcinoma of the thyroid.


Malabsorptive diseases of childhood no longer.


Differential diagnosis of liver abscess.


Physician response to delegation of well child care.


Aortocoronary bypass vein grafts: angiographic and clinical results at one year.


Norepinephrine and potassium fluxes in cardiac Purkinje fibers.


Circuit parameters of carotid collaterals.


Hemodynamic effects of isoproterenol on the pulmonary and systemic circulations in dogs.


Thermoregulatory adjustments of skin blood flow in chronically spinalized dogs.


Sodium and potassium balance during the administration of desoxycorticosterone in dogs with differing dietary sodium intakes.


Men, women and diabetes.

Men, women and diabetes.


The secretion of insulin.

The secretion of insulin.


Forty years of looking at diabetics' eyes.


Obesity and coronary heart disease.

Obesity and coronary heart disease.


Dietary factors in the aetiology of heart disease.


Experiences of coronary intensive care in a district hospital.


The cybernetics of "self": a theory of alcoholism.


Some moral dilemmas encountered in psychotherapy.


Goal-directed fantasy and the performance of hypnotic test suggestions.


Understanding reactive depression.

Understanding reactive depression.


Bronchial fracture following blunt chest trauma.


Porphyria in Hodgkin's disease.

Porphyria in Hodgkin's disease.


Alcohol.

Alcohol.


The incidence of syphilis in the Bantu: survey of 587 cases from Baragwanath hospital.


Gonadal dysgenesis, Turner's syndrome and phenotype in the South African Bantu.


The role of advice in child psychiatry.

The role of advice in child psychiatry.


The preponderance of chronic medical diseases and the value of continuing socio-medical care.


Tuberculoma of the liver in a child.

Tuberculoma of the liver in a child.


Walk or jog for health. I. The energy costs of walking or running at different speeds.


Walk of jog for health. II. Estimating the maximum aerobic capacity for exercise.


Advanced abdominal pregnancy: three cases with a review of the literature.


The delayed film in Hirschsprung's disease.


Nest predation affecting the breeding season of the clay-colored robin, a tropical song bird. Predation seems more important than food availability in determining the reproductive period of the clay-colored robin Turdus grayi. It breeds in the dry season when food resources are low. The rainy season brings more food but breeding stops, possibily because of greatly increased nest predation.


The extraction of vascular plasminogen activator from human cadavers and a description of some of its properties.


The May-Hegglin anomaly: ultrastructure of the granulocytic inclusion.


Acute aleukemic megakaryocytic leukemia: report of a case.


Translocation mongolism with virilizing adrenal hyperplasia.


Cancer of the uterine cervix. Janeway lecture, 1970.


Analysis of the treatment of stage I and stage II carcinomas of the uterine cervix.


Post-irradiational recurrent epidermoid carcinoma of the uterine cervix.


Dosage tolerance of pelvic structures with cobalt 60 rotation radiation therapy.


Ureteral strictures after radiation therapy for carcinoma of the uterine cervix.


Virulence indices and lymph nodes in cancer of the cervix.


The value of pelvic venography and lymphography in the clinical staging of carcinoma of the uterine cervix. Analysis of 105 proven cases by surgery.


The value of the inlet and outlet views of the pelvis in lymphography.


A review of experience with irradiation of brain metastasis.


Survival after surgical excision of single metastatic brain tumors.


Glioblastoma multiforme. An analysis of the results of postoperative radiotherapy alone versus radiotherapy and concomitant 5-fluorouracil. (A prospective randomized study of 32 cases).


Radiotherapy of primary lymphoma of the orbit.


Roentgenologic features of pulmonary carcinomatosis from carcinoma of the prostate.


Bone metastases in cancer of the esophagus.


Extra nodal spread of Hodgkin's disease.


Advanced, recurrent and-or unusual metastases in childhood malignancies. Illustrations of a "philosophical" approach to the use of radiation therapy.


Evaluation of a laboratory means of estimating respiratory water loss using the T-piece system.


The physician and the law.

The physician and the law.


Colistimethate and curare: a case report.


Unusual problems in airway management. II. The influence of the temporomandibular joint, the mandible, and associated structures on endotracheal intubation.


Gallamine in anesthesia for patients with chronic renal failure undergoing bilateral nephrectomy.


The obstetric anesthesioloist: his role in coagulation disorders in the parturient.


Prolonged shock resulting from pulmonary embolism: physiologic, diagnostic, and therapeutic considerations.


Evaluation of premedicants as protective agents against convulsive (LD50) doses of local anesthetic agents in rats.


Thoughts about medical writing. 3. The law.


Effect of methoxyflurane analgesia by "analgizer" on pain threshold, blood levels, electroencephalogram, and blood gas.


Systemic reaction to succinylcholine: a case report.


Capillary PO2 as a measure of sympathetic blockade.


Acute hypersensitivity reaction to penicillin during general anesthesia: a case report.


A grip to facilitate the insertion of epidural needles.


Successful treatment of malignant hyperthermia.


Allergic giant cell myocarditis complicating tuberculosis chemotherapy.


Studies in pain with the analgesic-demand system.


Acid-base response of the newborn to major surgery.


Changes in power spectra of electroencephalograms during anesthesia with fluroxene, methoxyflurane and ethrane.


Perforation and extravasation during transurethral surgery.


Left ventricular obstruction caused by metastatic sarcoma.


Hereditary elliptocytosis in a Chinese family.


Blood gases during intubation following two types of oxygenation.


Prisms and fiber optics for laryngoscopy.


The importance of preoperative pulmonary-function evaluation.


Facilities for treating terminal renal failure.


Children of divorce.

Children of divorce.


Diffusion hypoxia following nitrous oxide anesthesia.


Dissociative anesthesia for the severely burned child.


Anesthesia and Bell's palsy.

Anesthesia and Bell's palsy.


Effect on the incidence of postoperative sore throat of 1 percent cinchocaine jelly for endotracheal intubation.


Chlorpropamide in diabetes insipidus.

Chlorpropamide in diabetes insipidus.


Nephroblastoma and neuroblastoma in children.


Effect of psychiatric intervention in attempted suicide: a controlled study. All patients presenting at the casualty department of King's College Hospital during the first six months of 1968 with deliberate self-poisoning or self-injury were followed up. Of 211 patients 204 (97%) were traced after a mean interval of 18 months (range one to two years). Despite official hospital policy, 22% had not been seen by a psychiatrist before discharge; these 44 untreated patients were compared with the remaining 160 who had received either brief (one or two interviews) or more prolonged psychiatric and social help.Subsequent suicidal attempts occurred significantly more often among untreated than among treated patients, prolonged treatment being associated with the best prognosis. The same trend was observed in respect of actual suicide, though the numbers were small and differences did not reach statistical significance. These findings held good when the untreated and treated groups were controlled for other variables which were found to be correlated with outcome. These results indicate that psychiatric intervention is associated with a significant reduction in subsequent suicidal behaviour.


Prevention of postoperative deep venous thrombosis and pulmonary embolism. Two series of patients observed clinically and by phlebography suggest that one agent known to produce a reduction in platelet aggregation in vitro might be useful in reducing the incidence of deep venous thrombosis and pulmonary embolism postoperatively. The agent used in this study was hydroxychlorquine sulphate.


Effect of disodium cromoglycate on exacerbations of asthma produced by hyperventilation. The prophylactic inhalation of disodium cromoglycate lessens the exacerbations which occur in some asthmatic patients after voluntary hyperventilation. Reasons are given for considering this to be a possible mechanism for certain types of emotional exacerbation of the disease and for disodium cromoglycate giving sypmtomatic relief of asthma disproportionate to the improvement in routine measurements of ventilatory capacity. It is suggested that one clinical indication for giving disodium cromoglycate is to observe whether a fall in FEV(1) occurs after two minutes hyperventilation.


Gross oedema in the nephrotic syndrome treated with frusemide in high dosage. Five grossly oedematous patients with nephrotic syndrome required frusemide in doses of 250 mg/day or more. Two cases needed albumin infusions to initiate the diuresis. As oedema was removed renal function improved in four cases. There were no side effects. It is concluded that frusemide in the high doses used is a safe and effective diuretic.


Renal failure and glucocorticoid therapy.


Dysmenorrhoea.

Dysmenorrhoea.


Role of sympathectomy for hyperhidrosis.


Infectious mononucleosis.

Infectious mononucleosis.


Peritonitis in hyperosmolar non-ketotic diabetic coma.


Small drumsticks and long Y chromosomes.


Pancytopenia and meprobamate.

Pancytopenia and meprobamate.


Auditory memory for one and two tones.

Auditory memory for one and two tones.


The acoustic stapedius reflex in relation to critical bandwidth.


Pulmonary tuberculosis follow-up.

Pulmonary tuberculosis follow-up.


Loudness-intensity relations under various levels of contralateral noise.


Perception of coarticulated nasality.

Perception of coarticulated nasality.


Phonological oppositions in children: a perceptual study.


A conformational study of yeast phenylalanine transfer ribonucleic acid.


Medical care at the grass roots.

Medical care at the grass roots.


Inhaled foreign bodies in childhood. A review of 230 cases.


In-vitro thyroid tests in children.

In-vitro thyroid tests in children.


Factors which influence the effectiveness and complications of the Lippes loop.


Atypical case of leucinosis (maple syrup urine disease).


Regional enterocolitis (Crohn's disease). Clinical signs.


Ultrasoundcardiography in infancy and childhood.


Epilepsia termobalnearis--an unusual case of reflex epilepsia.


EEG and the clinical course after cerebral hypoxia in childhood.


Acid lysis of red blood cells in normal children.


L-asparaginase treatment of acute leukaemia in children.


Reconstruction of oesophagus with colonic transposition.


Lymphoblastic transformation, chromosome pattern and delayed-type skin reaction in ataxia telangiectasia.


Bilateral non functionning thecoma of the ovary in epileptic children under anticonvulsant therapy.


The behaviour of some indices of calcium-phosphate metabolism in Turner's syndrome.


Arteriovenous fistula for haemodialysis in children.


Trisomy 18 with ovarian dysgenesis.

Trisomy 18 with ovarian dysgenesis.


Arterial anomalies causing compression of the trachea and-or the oesophagus. A report of 30 symptomatic cases.


Foreign bodies in the gastrointestinal tract.


The child's place in the car.

The child's place in the car.


Temporomandibular joint disorders.

Temporomandibular joint disorders.


Surgical management of diverticulitis in the elderly.


Depression or disappointment?

Depression or disappointment?


The future of an illusion.

The future of an illusion.


Thyroid nodularity in Southwestern Utah school children exposed to fallout radiation.


International approach to nutritional anemias.


Lessons for the federal effort against hunger and malnutrition--from a case study.


The relationship of socioeconomic status to health.


The plan and the reality: training and utilization of paraprofessionals for service to the retarded.


Pregnancy testing as a fertility measurement technique: a preliminary report on field results.


Urban salmonellosis.

Urban salmonellosis.


Objective tinnitus aurium and dural arteriovenous malformations of the posterior fossa.


The averaged inion response evoked by acoustic stimulation: its relation to the saccule.


Staggered spondaic word test: support.

Staggered spondaic word test: support.


The use of a palatal stimulator to decrease velopharyngeal gap.


On foreign bodies and perforations of the esophagus.


Anomalous fusion of the malleus to the tympanic ring.


Vestibular influences on internuclear ophthalmoplegia.


Intraluminal pressure changes of the human esophagus.


Surgery in malignant tumors of the thyroid gland. A review of 15 years' experience with 225 cases.


Thromboembolism after Starr valve replacement.


Evaluation of pacing for heart block in myocardial infarction.


Repetitive tachycardia. Effects of exercise tests and amyl nitrite.


Cardiac tumours in infancy and childhood.


Atrioventricular dissociation in acute rheumatic fever.


Congenital heart disease in Nigeria. Necropsy study of 47 cases.


Pulmonary atresia with cyanosis. Report of two cases with ventricular septal defect and increased pulmonary blood flow.


Natural history of Ebstein's anomaly of the tricuspid valve in childhood and adolescence.


Fate of fixed membranous subartic stenosis after resection.


Mitral valve replacement using homograft semilunar valves.


Ischaemic heart disease risk factors in young managers.


Congenital coronary artery fistula: report of 17 cases with a note on natural history of legion.


Reversed reciprocal rhythm.

Reversed reciprocal rhythm.


Haemodynamic changes during paroxysmal tachycardia in a patient with Wolff-Parkinson-White syndrome.


Electrical alternation of T wave without change in QRS complex.


Drainage of left hepatic vein into coronary sinus associated with other systemic venous anomalies.


Rheumatic tricuspid stenosis. A haemodynamic correlation.


Aortic stenosis, sudden death, and the left ventricular baroceptors.


Effect of exercise and acclimatization on displacement apex cardiogram in normal young subjects.


Ebstein's anomaly. Clinical study of 32 patients in childhood.


Two contrasted cases of complete heart block observed over many years.


Hypertrophic cardiomyopathy with unusual features in a family.


Long-term pacing with an inductive coupling system.


Influence of body position on exercise tolerance, heart rate, blood pressure, and respiration rate in coronary insufficiency.


Coronary atherosclerosis in Nigeria.

Coronary atherosclerosis in Nigeria.


Bacteriuria again.

Bacteriuria again.


Plasma concentrations of digoxin after oral administration in the fasting and postprandial ste. After the oral administration of 0.5 mg of digoxin in tablet form to fasting subjects peak plasma levels were reached in 30 to 60 minutes. Levels then fell to reach a plateau at six to eight hours. When the same dose was given after food the peak plasma concentrations were significantly lower, but the concentrations reached in samples obtained from two to eight hours after the dose did not differ appreciably from corresponding samples obtained in the fasting experiments.In a four-week cross-over study of 21 patients on maintenance therapy, digoxin taken regularly in the fasting state produced plasma concentrations similar to those obtained when the drug was taken after meals.The rapid appearance of digoxin in the blood suggests that the oral route of administration is adequate for most patients who require rapid digitalization, and the timing of maintenance dosage in relation to meals is unimportant.


Intracarotid phenoxybenzamine for cerebral arterial spasm. Phenoxybenzamine was injected into the carotid artery of 23 patients after operations on their cerebral arterial aneurysms. Rapid improvement was seen in three cases with pronounced neurological disability. The other 20 were treated prophylactically in an attempt to prevent the onset of spasm. These results would appear to indicate that intracarotid phenoxybenzamine may be of value in the treatment of cerebral arterial spasm, provided that it is given before irreversible infarction of the brain has occurred. Until more is known about its action it would be best to give the drug only after operation.


Painful enlargement of left subtrapezoid lymph nodes in Graves's disease.


Drug interaction.

Drug interaction.


Pelvic pain.

Pelvic pain.


General practitioners and medical television.


Early walking of geriatric amputees.

Early walking of geriatric amputees. After amputation geriatric patients have been enabled to get up and walk with the help of a prosthesis, an "early walking aid." The physiotherapist measures the patient, fits the early walking aid, and instructs him in walking. The prosthesis is simple to make, easy to apply, and allows early walking with the use of a walking frame or sticks. Thus the geriatric amputee can walk as soon after operation as his general condition allows and the surgeon wishes.


Well-woman clinic in general practice.

Well-woman clinic in general practice. During a four-year period 1,169 women attended a well-woman clinic in a group practice. Eight positive smears were detected, together with one case of breast carcinoma, 94 cases of anaemia, and a number of other abnormalities. The clinic is part of a practice cervical-screening programme aimed at regular tests for women in the practice aged between 25 and 64. Patients appear to prefer attending screening clinics run by their own family doctor, and if more practices would adopt such a programme a higher proportion of the female population might be screened, and at a lower cost.


Xanthinuria discovered in population screening.


Urinary hydroxyproline and thyroid disease.


Cowpox in okapis Okapia johnstoni at Rotterdam zoo.


The pathogenesis of demodicosis in cattle in East Africa.


Limited insulin responses in older non-obese control subjects without glucose intolerance.


Mycotoxins and their role in oncogenesis, with special reference to blood diseases.


Combined surgical and medical treatment in geriatric surgery.


Final results of sixty-five cases of scoliosis treated by alloplasty of muscles.


Diabetes-like glucose and insulin patterns in a control population.


Drug dosage and remission duration in childhood lymphocytic leukemia.


On the origin of Ewing's tumor.

On the origin of Ewing's tumor.


Lysosomal enzyme activity in liver tissue, kidney tissue, and tumor tissue from patients with renal carcinoma.


Chronic granulocytic leukemia responding to melphalan.


Treatment of spinal cord compression in Hodgkin's disease.


Major surgery after radical radiotherapy. Indications and complications.


Depression of immunologic reactivity of patients with acute leukemia.


The Brenner tumor. A clinicopathologic study of 57 cases.


An intense clinicopathologic study of 305 teratomas of the ovary.


Invasion of the brain by a cellular blue nevus of the scalp. A case report with light and electron microscopic studies.


The clinical trial of an alkylating agent with a short half-life designed for intra-arterial chemotherapy.


A proposed staging for children with neuroblastoma. Children's cancer study group A.


Cultivation in vitro of cells derived from a human osteosarcoma.


A cell line from a human salivary gland mixed tumor.


Para-endocrine hypercalcemia in ovarian neoplasms. Report of mesonephroma with hypercalcemia and review of literature.


Disappearance of a tumor-associated antigen in malignant melanoma after imidazole carboxamide therapy.


Extreme squamous metaplasia in Hashimoto's thyroiditis.


Classification of fibroma and the coma of the ovary. An ultrastructural study.


Regional pulmonary function in metastatic carcinoma to the lung studied with xenon-133.


Effect of prior splenectomy on hematologic tolerance during total lymphoid radiotherapy of patients with Hodgkin's disease.


Deaths from phosphostigmine poisoning in Denmark. An analysis of the medico-social and medico-legal aspects.


Amphibian cells in vitro. I. Growth of Xenopus cells in a soft agar medium and on an agar surface.


Satellite DNA in calf heterochromatin.

Satellite DNA in calf heterochromatin.


Causal analysis of embryonic differentiation. I. Responsiveness of presumptive ectoderm as a regulating factor in RNA function.


Causal analysis of embryonic differentiation. II. Dual function of exogenous RNA in differentiation of presumptive ectoderm.


Zinc-calcium interrelationships in recurrent renal stone formation.


Pancreatic deoxyribonuclease. The role of dimerization in the reversible thermal inactivation at acid pH.


Hepatic sulfite oxidase. A functional role for molybdenum.


Hepatic sulfite oxidase. The nature and function of the heme prosthetic groups.


Assessing the risk associated with behavior patterns.


Value of bed rest in patients with rheumatoid arthritis.


Obstetrical delivery after jejuno-ileostomy for obesity.


Immunologic reactions of bronchial tissues in asthma.


Heart block in polymyositis.

Heart block in polymyositis.


The thalidomide tragedy in Germany: the end of a historic medicolegal trial.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 9-1971.


Dental extraction in hemophiliacs.

Dental extraction in hemophiliacs.


Pesticide residue analysis in the presence of polychlorobiphenyls (PCB's).


Spontaneous abdominal aorto-vena caval fistula. A mechanism for acute intractable cardiac failure.


Melanoma in Utah.

Melanoma in Utah.


Hypospadias. One-stage repair.

Hypospadias. One-stage repair.


Hypospadias. Two-stage repair.

Hypospadias. Two-stage repair.


What's the rhythm?

What's the rhythm?


Maternal mortality. Coagulopathies.

Maternal mortality. Coagulopathies.


Compromised renal function secondary to spontaneous retroperitoneal hemorrhage.


Interposition of the colon between the liver and diaphragm.


Colorado tick fever. Clinical and epidemiologic features and evaluation of diagnostic methods.


Tumor conference from University of Colorado Medical Center. Chemodectomas of the ear.


Iridocyclectomy. A review. Gleanings from the literature.


A clinicopathologic report on treated retinoblastoma.


Total unilateral visual loss following orbital surgery.


Hemorrhagic complications of drusen of the optic disk.


Hereditary macular degeneration and amino-aciduria.


Fluorescein studies of choroidal sclerosis.


Jamaican optic neuropathy in immigrants to the United States.


Fluoroangiographic pattern of macular edema and retinal swelling in postmortem eyes.


Treatment of intraretinal angiomas.

Treatment of intraretinal angiomas.


Restriction in upward gaze with advancing age.


Management of persistent hypotony after planned or inadvertent cyclodialysis.


Iris mechanics. I. Influence of pupil size on dynamics of pupillary movements.


Refraction of patients with incipient cataract.


Mooren's ulcer.

Mooren's ulcer.


Bilateral peripapillary staphyloma with normal vision.


Amazonian ophthalmology.

Amazonian ophthalmology.


Exaggerated cold-pressor response in patients with atherosclerotic vascular disease.


Femoral steal syndrome.

Femoral steal syndrome.


Aspirin: effect on thrombus formation time and prothrombin time of human subjects.


Angiographic and plethysmographic assessment of graduated physical exercise in the treatment of chronic occlusive arterial disease of the leg.


The neurologically intact brain injured (2 degrees to missiles): an approach to treatment.


Congenital coronary arteriovenous fistulas.


Mustard procedure as a second stage for total correction of transpositions with previous Baffes operation.


A comparative study of lung compliance and pulmonary surfactant activity in human subjects.


Extending operability in lung cancer involving the heart and great vessels.


Current concepts of thoracic surgery in the management of lymphoma.


Persistent left superior vena cava draining into the left atrium with absent right superior vena cava.


Left atrial inferior vena cava with atrial septal defect.


Intraoperative evaluation of surgical systemic-to-pulmonary artery shunts.


Acute traumatic rupture of the thoracic aorta with secondary necrosis of the esophagus.


Additional kinetic distinctions between normal pyruvate kinase and a mutant isozyme from human erythrocytes. Correction of the kinetic anomaly by fructose-1,6-diphosphate.


Use of oxprenolol in cardiac arrhythmias associated with acute myocardial ischaemia. Oxprenolol, a new beta-receptor blocking drug with intrinsic sympathomimetic activity, was used to treat 63 episodes of cardiac arrhythmia occurring in 43 patients with acute myocardial infarction or myocardial ischaemia. The drug was most effective in abolishing ventricular ectopic beats and supraventricular tachycardia. The best method of administration was by continuous intravenous infusion and the most satisfactory bolus does was 6 mg. The main side effect was hypotension, which occurred in 59% of episodes of arrhythmia that had responded previously to intravenous administration. Oxprenolol was often effective in lignocaine-resistant arrhythmia. The two main advantages of oxprenolol over propranolol are the reduced likelihood of adversely affecting myocardial function and the diminished tendency to produce bronchospasm.


Incidence of side effects from levodopa during the introduction of treatment. Twenty patients with Parkinsonism were investigated in order to establish whether the gradual introduction of treatment with levodopa allows a higher dose to be tolerated than can be achieved if treatment is introduced rapidly. No indication was obtained that slow introduction of treatment offers an advantage in maximum tolerated dose, and patients aged 65 and over responded similarly in this respect to those under 65. The maximum tolerated dose is slightly lower in the elderly patient. The incidence of the different side effects does not appear to be affected by the rate of increasing the dose of levodopa.


Drug-induced pulmonary hypertension?

Drug-induced pulmonary hypertension? Of 40 patients with obstructive pulmonary hypertension studied in Basle, Switzerland, during the period 1966-68, 32 had been taking an anorectic drug, aminorex fumarate. Rapidly progressing exertional dyspnoea, central chest pain, and syncope on effort were characteristic features. The absence of the usual causes of pulmonary vascular disease seems to suggest the possibility of drug-induced pulmonary hypertension. Further studies are necessary, however, to clarify the role of aminorex fumarate in this condition.


Gynaecological examination and equipment in the surgery.


Intraperitoneal insulin for control of blood sugar in diabetic patients during peritoneal dialysis. We have added insulin to peritoneal dialysis fluid in three uraemic diabetic patients. The hyperglycaemia and pronounced fluctuations in blood glucose which complicate peritoneal dialysis in diabetic subjects have not occurred with this technique. Studies with (131)I-labelled insulin showed that less than 5% of the intraperitoneally administered insulin was absorbed during a one-hour exchange. While the physiology of the procedure needs further evaluation, this procedure has reduced the morbidity of peritoneal dialysis in diabetic patients and made its management easier.


Success and failure in human virus diseases. I. Aetiology.


Myotonia. A review of its clinical implications.


Q fever in Los Angeles County. Serological survey of human and bovine populations. Q fever is endemic and enzootic in Los Angeles County. A serological survey conducted in 1949 is compared with a current survey. Infection in dairy herds is now almost universal, while the prevalence of positive complement fixation titers in man only increased from 1.2 percent to 2.3 percent (p <0.10). The relative stability in man is accounted for by the increase in temperature requirements for milk pasteurization, the decrease in consumption of raw milk and the decrease in the number of dairy farm foci.


Congestive heart failure after acute myocardial infarction. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs. Sydney E. Salmon and Robert W. Schrier, Assistant Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.


Foramen of Bochdalek hernia with acute tension of displaced organs.


Further words about DDT.

Further words about DDT.


Mithramycin as a possible cause of toxic epidermal necrolysis (Lyell's syndrome).


Effects of intermittent noise on the performance of a complex psychomotor task.


Vision and driving: a report on research.


On the conservation of simple concepts: generality of the affirmation rule.


The use of trimethoprim and sulphamethoxazole in the management of chronic and recurrent upper and lower urinary tract infection.


Ventricular septal defect caused by a penetrating wound of the heart.


A case of organophosphorus-induced psychosis.


Epidemic polyarthritis in Eastern Australia, 1959-1970.


Studies in depression. 1. Cingulo-tractotomy in the treatment of severe affective illness.


Blood acid-base status in acutely water-depleted rats.


Electrical activity of a single fibre of the human embryonic heart.


The influence of lissamine green on tubular reabsorption of electrolytes and water in rats.


Control by insulin of sodium potassium and water excretion by the isolated dog kidney.


Deformability and migration speed of red cells centrifuged at low g-values.


Decreased red-cell deformability after severe burns, determined with the chlorpromazine test.


The effect of veratridine on Helix pomatia neurones.


Slow changes of membrane permeability in giant neurones of Helix pomatia.


Significance of diffusion loss of oxygen in determining respiration of isolated, perfused organs.


Psychiatric aspects of therapeutic abortion.


Diagnostic resources available to the physician.


Variability of facial and dental characteristics in trisomy G.


Psychologic findings associated with the XO, XXY, and XYY anomalies.


Growth deficiency: a new classification into primary cellular growth deficiency and secondary humoral growth deficiency.


Autosomal aberration syndromes.

Autosomal aberration syndromes.


Pancreatitis--cause, etiologic factors, and complications.


Prospects for biochemical treatment of genetic disorders.


Prevention of experimental and of naturally occurring ovine abortion due to toxoplasmosis.


Ovine abortion due to experimental toxoplasmosis.


Metabolic profiles.

Metabolic profiles.


The aerobic bacterial flora of the reproductive tract of the mare.


The liver-fluke Platynosomum fastosum in domestic cats.


Pathological changes in the central nervous system of a bull affected with spastic paresis.


Declawing the domestic cat: the technique of onychectomy.


Feline rabies.

Feline rabies.


Tetanus in cattle.

Tetanus in cattle.


Myasthenic-like response in patients with neuropathy.


Assessment of motor performance in brain injury. A bio-engineering method.


Conscious control of motor units in a tonic muscle. The effect of motor unit training.


Are the ranks closed? Attitudinal social distance and mental illness.


Depressive disease: familial psychiatric illness.


Casual versus heavy use of marijuana: a redefinition of the marijuana problem.


Induced abortion for psychiatric indication.


Drug use in a black ghetto.

Drug use in a black ghetto.


Assault and homicide associated with amphetamine abuse.


Mania and the use of lithium: a three-year study.


On acquiring a kidney.

On acquiring a kidney.


After transplantation--the child's emotional reactions.


Social and emotional adaptations of children with transplanted kidneys and chronic hemodialysis.


Suicidal behavior in chronic dialysis patients.


Suicide in chronic hemodialysis patients from an external locus of control framework.


Who should be dialyzed?

Who should be dialyzed?


Medical student radicals: conflict and resolution.


Group psychotherapy: its effects on mothers who rate social performance of retardates.


Unipolar and bipolar affective illness. Differences in clinical characteristics accompanying depression.


Pseudocyesis. A paradigm for psychophysiological interactions.


A study of personality assets in a rural community.


Agranulocytosis, leukopenia, and psychotropic drugs.


Acetophenazine and diazepam in anxious depressions.


Television violence. Guidelines for evaluation.


Mexican-American bilingualism and the perception of mental illness.


Surgery for large glomus jugulare tumor. The combined suboccipital, transtemporal approach.


Vertical, subtotal laryngectomy and laryngoplasty. Review of experience.


Control of hypoparathyroidism after extensive neck surgery.


Malignancies of the parotid gland.

Malignancies of the parotid gland.


Survival rates in cancer of the tongue, tonsil, and hypopharynx.


Epidermoid carcinoma of the floor of the mouth. Analysis of 108 cases.


Intelligibility of the esophageal speaker. Relationship of intelligibility to overall ratings.


Electrical stimulation of the human cochlea. A preliminary report.


Pathologic quiz case 1.

Pathologic quiz case 1.


Sarcoidosis of the skin and larynx.

Sarcoidosis of the skin and larynx.


Pathologic quiz case 2.

Pathologic quiz case 2.


Porcine mycotic abortion caused by Aspergillus fumigatus.


Haemolytic disease of newborn calves in a dairy herd in Queensland.


Rabies in Great Britain.

Rabies in Great Britain.


Leptospira hardjo in Tasmania.

Leptospira hardjo in Tasmania.


Biological significance, genetics and evolutionary origin of variability in behaviour within and between inbred strains of mice (Mus musculus). A behaviour genetic study.


Children's judgements of duration.

Children's judgements of duration.


The factorial structure of juvenile delinquency: a study of self-reported acts.


A study of regenerated synovium after synovectomy of the knee in rheumatoid arthritis.


Information processing in schizophrenia: the effect of varying the rate of presentation and introducing interference.


Chronic synovitis as a manifestation of calcium crystal deposition disease.


The effect of speed on comprehension in schizophrenia.


Decision processes and obsessional behavior.


Acute arthritis complicating rubella vaccination.


The use of the MMPI for personality study of Singapore students.


Treatment with colchicine of the periarticular inflammation associated with sarcoidosis: a need for continued appraisal.


Abuses of sensitivity training on the American campus.


Treatment of the adolescent with borderline syndrome. A problem in separation-individuation.


Canine rheumatoid arthritis; a case report.


Anemia as a presenting manifestation of giant cell arteritis.


Electrophoretic properties of pituitary gonadotropins as studied by electrofocusing.


Blood flow and progestin levels in the ovaries of the pregnant rabbit.


Levels of prolactin, LH and FSH in the serum of intact and pelvic-neurectomized rats.


The effects of vocal mediating responses on visual motor tasks with deaf and hearing children.


Behavioral and academic gains of conduct problem children in different classroom settings.


The role of nonprofessional persons in teaching language skills to mentally retarded children.


Language of the mildly mentally retarded: cognitive deficit or cultural difference?


The child oriented resource room program.


Classroom exclusion in a children's psychiatric hospital.


Rhinosporidiosis in Raipur Madhya Pradesh, India.


Treatment of sinusitis with a nitrofurazone--phenylephrine preparation.


Steroid dependent asthma.

Steroid dependent asthma.


A general intellectual factor affected by temporal lobe dysfunction.


Group size, occupational status and psychological symptomatology in an extreme environment.


The stability of chronic schizophrenic speech on a standardized video-tape interview.


Mental illness and peer group popularity.


Unilateral brain damage and patterns of age-corrected WAIS subtest scores.


Differentiation of schizophrenia and brain damage with the WAIS.


An investigation of the Sherman Mental Impairment Test: a normative study.


Factor analytic structure of the short form MMPI items in a VA hospital population.


False positives galore: the application of standard MMPI criteria to a rural, isolated, Negro sample.


A cross-validation of Gilberstadt and Duker's 1-2-3-4 profile type.


An MMPI comparison of three groups of criminals.


Age and sex differences on MMPI factor scales ER-0 and EC-5 in a medical population.


Personality dimension and the Self-Rating Depression Scale.


CPI correlates of stimulus-seeking in male alcoholics.


Projected "eye" responses and sensitivity to the opinions of others.


Feminine tendencies in figure drawings by male homosexual retarded dyads.


The use of the Draw-A-Man test with borderline retarded children without pronounced pathology.


Perceptual development at the kindergarten level.


The effects of therapist focus on patient anxiety source and the interaction with therapist level of accurate empathy.


Dimensions of psychotherapy: a factor-analytic study of ratings of psychotherapy sessions.


Effects of modeling and reinforcement on adult chronic schizophrenics.


A multimethod factor analysis of behavioral and objective measures of psychopatholog.


Schizophrenic short-term memory: the role of organization at input.


Susanville: a community helps itself in mobilization of community resources for slef-help in mental health.


Effects of failure on the self-esteem of depressed and nondepressed subjects.


Modes of temporal orientation and psychopathology.


Personality antecedents and correlates of drinking patterns in women.


Temporal correlates of dogmatism.

Temporal correlates of dogmatism.


An experimental analog of public speaking.


Binding of ribonucleic acids to the RNP-antigen protein of influenza viruses.


Investigation of plaque formation in chick embryo cells as a biological marker for distinguishing herpes virus type 2 from type 1.


Effects of arginine deprivation on polyoma virus infection of mouse embryo cultures.


Infections of the human central nervous system by myxovirus-paramyxovirus following the attenuated measles virus vaccine.


Dominant olivopontocerebellar atrophy with dementia and extrapyramidal signs: report of a family through three generations.


Superficial siderosis of the central nervous system.


Virus like filaments and phospholipid accumulations in a case of chronic myopathy.


Isolation and preliminary characterization of Alzheimer plaques from pre-senile ans senile dementia.


Preliminary isolation and fine structure analysis of the Alzheimer neurofilament.


Qualitative and quantitative differences in sulfatase A which distinguish different forms of classical metachromatic leukodystrophy (MLD).


Neuronal fibrous protein in human pathology.


Relationships among self-ideal congruence, adjustment, and fear-of-failure motivation.


Personality and discrepancies between verbal reports and physiological measures of private emotional experiences.


Embarrassment, facework, and eye contact: testing a theory of embarrassment.


Facilitating effects of daily contact between partners who make a decision to cut down on smoking.


Effect of stress, knowledge of results, and proactive inhibition on verbal recognition memory (d') and response criterion (Lx).


Anxiety, defensiveness, and differential prediction of performance in stress and nonstress conditions.


Birth order and mother-child interaction in an achievement situation.


Effects of aggressiveness habit strength on behavior in the presence of aggression-related stimuli.


Opportunity for information search and the effect of false heart-rate feedback.


Sociopathy and serial learning of CVC combinations with high and low social content ratings.


Serotyping and genetic analysis in the selection of related renal-allograft donors.


Serum IgE concentrations and skin reactivity to anti-IgE antibody in IgA-deficient patients.


Postoperative psychosis in cardiotomy patients. The role of organic and psychiatric factors.


Improved glucose tolerance with high carbohydrate feeding in mild diabetes.


Torulopsis glabrata fungemia during prolonged intravenous alimentation therapy.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1971.


Psychologic processes and ischemic stroke (occlusive cerebrovascular disease). I. Observations on 32 men with 35 strokes.


Anorexia nervosa in the male.

Anorexia nervosa in the male.


The role of body attitudes and acquiescence in epinephrine and placebo effects.


Short-term treatment in child psychiatry.


Behavior modification in the treatment of obesity.


Radioisotope organ imaging in tumor diagnosis and management.


Exocrine pancreatic function in patients with amyotrophic lateral sclerosis.


Learned control of cardiovascular integration in man through operant conditioning.


Role of the duodenum in vitamin D3 absorption in man.


Effect of nausea on human gastric secretory responses.


Simple fecal tests of absorption. A prospective study and critique.


Detection of molecular motion in lyophilized myelin by nuclear magnetic resonance. Proton resonance spectroscopy was used to determine the state of the hydrocarbon regions in lyophilized and resuspended samples of nerve myelin. Measurements of the resonance line width indicate considerable freedom of motion within the hydrocarbon moiety of the myelin samples. Sharp thermal transitions of the line width were observed, suggesting that lyophilized myelin is in a liquid crystalline state.


Local inhibition of ruffling during contact inhibition of cell movement.


Temperature effects on multi-enzyme systems in single living ascites cells.


Growth-stimulating activities of mouse submaxillary esteropeptidases on chick embryo fibroblasts in vitro.


Radioautography technique for human and rat seminiferous tubules mounted in toto.


RNA synthesis during lens cell differentiation.


Isolation of protoplasts from the placental cells of Lycopersicum pimpinellifolium Mill.


Egg white avidin. II. Isolation, composition, and amino acid sequences of the tryptic peptides.


Egg white avidin. 3. Sequence of the 78-residue middle cyanogen bromide peptide. Complete amino acid sequence of the protein subunit.


Elongation of the disulfide bonds of bovine pancreatic ribonuclease and the effect of the modification on the properties of the enzyme.


Identification of essential carboxyl groups in the specific binding site of bovine trypsin by chemical modification.


N-acetylneuraminic acid analogues. I. Preparation of the 8-carbon and 7-carbon compounds.


Radioactive labeling of proteins in vitro.


Dimensions of the normal adult spleen scan and prediction of spleen weight.


Uptake of 85Sr by an osteosarcoma metastatic to lung.


Thyroid nodule scans made with pertechnetate and iodine may give inconsistent results.


Current evaluation and treatment of headache.


Local anesthetic toxicity in obstetrics. Case report.


A need for pediatric guidance.

A need for pediatric guidance.


Immunofluorescent and histologic findings in the hemolytic uremic syndrome.


Stiff skin syndrome.

Stiff skin syndrome.


The use of buffered L-arginine in the treatment of cystic fibrosis.


Nitrogen dioxide and lower respiratory illness.


Chronic illness in childhood. I. Epidemiological and clinicl characteristics.


Utilization of services at a neighborhood health center.


Psychosocial study of childhood poisoning: a 5-year follow-up.


Studies of the school age child with meningomyelocele. I. Physical and intellectual development.


Selective hearing loss: clues to early identification.


Intraspinal neurilemoma in association with the Rubinstein-Taybi syndrome.


Annual summary of vital statistics--1969.


Antinauseant drugs in treatment of epidemic or virus gastritis?


Bronchography outmoded? A radiologist comments.


Scleroderma and the subcutaneous tissue. Our study revealed that as observed with both light and electron microscopy the most specific abnormality in sclerodermna skin is the replacement of the subcutaneous tissue by markedly abnormal connective tissue.


Possible etiology of schizophrenia: progressive damage to the noradrenergic reward system by 6-hydroxydopamine. Single or repeated intraventricular injections of 6-hydroxydopamine caused marked and long-lasting deficits in brain self-stimulation and other rewarded behaviors in the rat. The behavioral deficits, as well as the depletion of brain norepinephrine induced by 6-hydroxydopamine, were prevented by prior treatment with chlorpromazine. Episodic or continuous formation of endogenous 6-hydroxydopamine in man as a result of a genetically determined enzymatic error could selectively damage the binding capacity and, eventually, the structural integrity of the noradrenergic reward mechanism. Such damage might cause the fundamental symptoms and long-term downhill course of schizophrenia.


Toxaphene toxicity in protein-deficient rats.


The influence of certain factors on the healing time of leg ulcers in ambulant patients.


Bleeding disorders due to platelet dysfunction.


Chediak-Higashi syndrome in a child with Hodgkin's disease.


Secondary amyloidosis in ocular leprosy.


"Holes" in Bruch's membrane.

"Holes" in Bruch's membrane.


Glutamine synthetase in the normal human retina.


Intraocular involvement in Burkitt's lymphoma.


Juxtapapillary retinal pigment epithelial tumor. Adenocarcinoma vs reactive hyperplasia.


Registry of interesting cases. Transient cortical blindness and cerebellar ataxia associated with mumps.


Pigmentary epitheliopathy and erythema nodosum.


Basaloid tumors of anal region.

Basaloid tumors of anal region.


Brown spider bites in Arizona.

Brown spider bites in Arizona.


Problems of exercise testing.

Problems of exercise testing.


Parasternal chest wall involvement in Hodgkin's disease.


Use of single-stage exercise test with individually adjusted work load in electrocardiographic diagnosis of ischemic heart disease.


Bronchopulmonary lavage in asthma and chronic bronchitis: clinical and physiologic observations.


Calcification of the pulmonary valve.

Calcification of the pulmonary valve.


Retrograde ventriculoatrial conduction in patients with acute myocardial infarction.


Left bundle branch block and left ventricular hypertrophy: electrocardiographic-pathologic correlations.


Idiopathic hypertrophic subaortic stenosis; surgical treatment.


Plasma insulin response to an oral glucose load in noncoronary heart disease.


Rapid intravenous calcium infusion test in sarcoidosis.


Near drowning in humans. A report of 36 patients.


Endocarditis after cardiac valvular replacement.


Left atrial parasystole.

Left atrial parasystole.


Fever, anemia and mediastinal mass.

Fever, anemia and mediastinal mass.


Carcinoma of the esophagus engrafted on lye stricture.


Tricuspid valve subacute bacterial endocarditis complicating tetralogy of Fallot.


Massive hemothorax complicating heparin therapy for pulmonary infarction.


On the mechanism of hemoglobin-haptoglobin complex formation.


A congenital aural deformity and its correction.


The action pattern of mammalian deoxyribonuclease IV.


Fluoresceinangiographic features of the limbus and perilimbal vessels.


Air embolism.

Air embolism.


Sensory innervation of the skin and mucosa of some parts of the head in the domestic fowl.


Isolation versus grouping effects on adrenal and gonadal function in albino mice. I. The male.


Lawsuit involving source of hepatitis outbreak.


Impact of TV violence on children.

Impact of TV violence on children.


Effects of desegregation of a state hospital system on rates of treated mental illnesses.


Trends and patterns of dental care in an urban area before medicaid.


The management of adolescent pregnancy and prevention of repeat pregnancies.


Epidemiology of exogenous estrogens.

Epidemiology of exogenous estrogens.


A physician visits Little Diomede.

A physician visits Little Diomede.


Smallpox occurrence in the município of São Paulo, Brazil, 1945-69.


Use of aides in preventing an outbreak of diphtheria in a housing project.


Agoraphobia: a case study in hypnotherapy.


The effect of hypnotically induced and nonhypnotic mood changes on the Rorschach test.


The affect bridge: a hypnoanalytic technique.


Cattle behavior on subalpine range in southcentral Alaska.


Maintenance of unilateral pregnancy in the pig with induced corpora lutea.


Response of lactating dairy cows to high levels of dietary molybdenum.


From the files of the Committee for the Study of Maternal Mortality.


Giant cell reparative granuloma.

Giant cell reparative granuloma.


Vascular tumors of the neck.

Vascular tumors of the neck.


Amputation in hemophilia.

Amputation in hemophilia.


Periarteritis nodosa presenting as mass in testis.


Xanthogranulomatous pyelonephritis: a comprehensive review with report of 4 additional cases.


Clinical effectiveness of intramuscular sodium nitrofurantoin against urinary tract infections.


Serum creatine phosphokinase levels following endoscopic urologic procedures.


Nocturnal functional bladder capacity in eneuretic children.


Pre-school urinary tract diversion for children with neurogenic bladder from myelomeningocele.


Testicular tumors in infants and children: report of 5 cases and evaluation of different modes of therapy.


Human homotransplantation of normal and neoplastic tissue from the same organ.


Acute renal failure in multiple myeloma.


Renal angiomyolipoma (hamartoma): review of the literature and report of 7 cases.


Non-idiopathic retroperitoneal fibrosis.


Spontaneous disappearance of iatrogenic renal arterio- venous fistula: report of a case.


Delayed ureteral fistula from high velocity missiles: report of 3 cases.


Ten cases of vesicoureteral reflux in young women with urinary tract infection.


The cutaneous vesicostomy reappraised.

The cutaneous vesicostomy reappraised.


Ureteral injury secondary to lumbar disk operation.


Vesical dysfunction caused by protruded lumbar disk.


The management of bladder tumors in a community hospital.


Ectopic prostatic tissue in urethra: a clinocopathological entity and a significant cause of hematuria.


The Michigan physician: his use and evaluation of the professional meeting and pg course.


Prosthetic replacement of the aortic valve: a current assessment of operative results.


Perinatal tips.

Perinatal tips.


Delta-aminolevulinic acid dehydratase activity in circulating blood cells. A sensitive laboratory test for the detection of childhood lead poisoning.


Hydatidiform mole--a cause of clinical hyperthyroidism. Report of two cases with evidence that the molar tissue secreted a thyroid stimulator.


Hazard to health--liquid lye.

Hazard to health--liquid lye.


Altruism in disrepute. Medical versus public attitudes toward the living organ donor.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 11-1971.


Accidental poisoning and the law.

Accidental poisoning and the law.


Lactation as a denial of separation.

Lactation as a denial of separation.


Temporal anniversary manifestations: hour, day, holiday.


The fee as a therapeutic tool.

The fee as a therapeutic tool.


Altered states of consciousness: an experimental case study.


Schizophrenia: conflict and deficiency.

Schizophrenia: conflict and deficiency.


Closed circuit tv monitor and culture chamber incubator for tissue culture studies.


Intracytoplasmic hyaline inclusion bodies in the nerve cells of the hypoglossal nucleus in human autopsy material.


Skeletal muscle capillary basement membranes in humans.


Results of counterpulsation in patients with coronary artery disease.


Clinical management ancillary to phase-shift balloon pumping in cardiogenic shock. Preliminary comments.


The circulation time in the aged.

The circulation time in the aged.


Blood volume changes in cyanotic congenital heart disease.


Pulmonary alveolar hemorrhage. A common finding in patients with severe cardiac disease.


Renal trauma and hypertension.

Renal trauma and hypertension.


Use of bretylium tosylate in the management of acute myocardial infarction.


Interrupted aortic arch: surgical treatment.


Anomalous origin of left coronary artery from pulmonary artery. Treatment by aorto-left coronary saphenous vein bypass.


Traumatic aneurysm of the left coronary artery.


Temporary pervenous pacing catheter insertion through a tricuspid prosthetic valve.


Surgical findings in van der Hoeve's syndrome.


Homograft tympanic membrane in tympanoplasty.


Malignant lymphomas of the major salivary glands.


Changes in hearing associated with the glycerol test.


A new concept of the pathogenesis of presbycusis.


Fibrinous laryngotracheobronchitis in children.


Extracorporeal cardiopulmonary bypass and hearing.


Surgery of Stensen's duct.

Surgery of Stensen's duct.


Autosomal recessive deafnessassociated with short stature, vitiligo, muscle wasting and achalasia.


Anesthesiology 1969.

Anesthesiology 1969.


Pathologic quiz case 1.

Pathologic quiz case 1.


Pathologic quiz case 2.

Pathologic quiz case 2.


Cancer in Africa.

Cancer in Africa.


A pilot graduate seminar concerning speech and hearing problems of the chronically ill and the aged.


Hypertension.

Hypertension.


Validation of screening procedures.

Validation of screening procedures.


Early environmental influences on the development of intelligence.


Pneumoconiosis and coal dust exposure.

Pneumoconiosis and coal dust exposure.


The epidemiological importance of childhood cancers.


Effects of treatment on tyrosine tolerance in thyroid disease. A modified tyrosine assay.


Rheumatic complaints.

Rheumatic complaints.


The life cycle and seasonal variation of Davainea tetraoensis Fuhrmann 1919, a cestode parasite of ruffed grouse, Bonasa umbellus (L.).


Normal clinical chemical values for pregnant women at term.


A simple method for separate determination of delta 4- and delta 1,4-corticosteroids in urine.


Measurement of "free" thyroxine in serum.


Comparison of laboratory test results for assessing thyroid function in normal subjects and treated and untreated hyper- and hypothyroid patients.


Serum cholinesterase variants: examination of several differential inhibitors, salts, and buffers used to measure enzyme activity.


A manual and automated procedure for measuring serum cholinesterase activity and identifying enzyme variants. Differentiation by means of Tris and phosphate buffers.


Serum lipid concentrations in patients with coronary arteriosclerosis demonstrated by coronary arteriography.


Diabetes detection with a comparison of screening methods.


Insulin secretion in relation to adipose tissue in men.


Influence of nutritional factors on prevalence of diabetes.


Haloperidol in 60 criminal psychotics.

Haloperidol in 60 criminal psychotics.


The quality of life before and after renal transplantation.


Long term camping for emotionally disturbed boys.


Chlorprothixene-enforced sleep for newly admitted patients with acute mental decompensation.


Depression, back pain, and disc protrusion. Relationships and proposed psychophysiological mechanisms.


Epinephrine-cyclizing enzyme in schizophrenic serum. Preliminary report.


Clinical neuropathological conference.

Clinical neuropathological conference.


The fine structure of cells in the rat metrial gland.


Surface characteristics of human articular cartilage--a scanning electron microscope study.


The development, structure and growth pattern of the human mid-palatal suture.


Valve replacement in active bacterial endocarditis.


Infection with Vibrio fetus in the immunologically immature fetal calf.


Cholera reinfection in man.

Cholera reinfection in man.


Meningococcal carriage in a population of "normal" families.


Mycoplasma pneumoniae disease: clinical spectrum, pathophysiology, epidemiology, and control.


The retained gastric antrum: clinical considerations.


Clinical experience with acute peptic gastrointestinal ulcers.


Femoral shortening for leg-length discrepancy.


On the increased association of Graves' disease with pernicious anemia.


Truncus arteriosus with interruption of the aortic arch: report of a case successfully repaired.


Clinical experiences with permanent demand pacemakers.


45,X cell lines in adult men: loss of Y chromosome, a normal aging phenomenon?


Inhibition of influenza RNA polymerase by specific antiserum.


An avian leukosis virus related to RSV(O): properties and evidence for helper activity.


Ontogeny of behaviour and psychiatry. An accounting for the symposium theme.


Noninfectious RSV deficient in DNA polymerase.


Isolation of the nucleic acid of feline leukemia virus.


Intracellular structures involved in Sendai virus replication.


Observation of exploratory behaviour of preschool children alone and in the presence of the mother.


Experience with the sensation-seeking-scale by Zuckerman in speech disorders.


Children in restricted environments.

Children in restricted environments.


Early experience and the development of social behaviour in junglefowl.


The diurnal rhythm of adrenaline secretion in subjects with different working habits.


Interindividual differences in diurnal variations in alertness, performance, and adrenaline excretion.


Temperature regulation during continuous and intermittent exercise in man.


Transient dynamics of ventilation and heart rate with step changes in work load from different load levels.


Daily walking exercise in treatment of intermittent claudication: it works.


Connective tissue composition of human coronary artery and its relationship to divalent cation context.


Vasomotor tone and vascular responses to local cold in primary Raynaud's disease.


The quantitative analysis of occlusive peripheral arterial disease by a non-intrusive ultrasonic technique.


An experimental technique for the study of unconscious conflict.


Cigarette smoking: natural history of a dependence disorder.


The home background of the severely subnormal child: a second study.


On disillusionment: the desire to remain disappointed.


The motivation and emotional state of 91 cases of attempted suicide.


Cognitive dysfunction in childhood and adult psychosis.


Patterns of masochism: an empirical study.


A parsimonious theory of overinclusive thinking and retardation in schizophrenia.


Emergency treatment of accidental hypothermia.


Training children to work productively in classroom groups.


Techniques for screening conduct disturbed children.


Children with learning problems: academic history, academic prediction, and adjustment three years after assessment.


Materials to prepare children for hospital experiences.


The not so specific learning disability population.


Ethnic and social status characteristics of children in EMR and LD classes.


Psychoeducative considerations of physical handicapping conditions in children.


Academic achievement and minimal brain dysfunction in mentally retarded children.


Attitudes concerning undergraduate programs for the preparation of teachers of the emotionally disturbed.


Hemiblock and cardiac arrhythmias.

Hemiblock and cardiac arrhythmias.


The U waves in cardiac arrhythmias.

The U waves in cardiac arrhythmias.


Beta-blocking agents in the management of cardiac arrhythmias.


Importance of compulsory mass x-rays for early diagnosis of lung cancer.


Management of bleeding oesophageal varices by draining lymph from the thoracic duct. The thoracic duct was cannulated in six patients who were actively bleeding from varices and had not responded to conservative treatment but draining lymph from the thoracic duct did not control bleeding in five patients. There was no drop in intrasplenic pulp pressure following this procedure when recorded in three of these patients. Bleeding stopped in one patient after lymph had been drained for nine and a half hours, and there was only a modest change in intrasplenic pressure. The therapeutic use of this technique to control oesophageal varices could not be substantiated.


A cytohormonal study of postmenopausal women.


Drug usage and related patterns of behavior in university students. I. General survey and marihuana use.


Constipation in infants and children.

Constipation in infants and children.


Weight lifting injuries.

Weight lifting injuries.


Tropical pulmonary eosinophilia.

Tropical pulmonary eosinophilia.


Comparison of diagnostic tests for infectious mononucleosis.


A successfully treated case of Mendelson's syndrome.


Drugs--a report on a study in Dublin. Post-primary schoolchildren, 1970.


Proteins and glycoproteins of paramyxoviruses: a comparison of simian virus 5, Newcastle disease virus, and Sendai virus. The polypeptides of three paramyxoviruses (simian virus 5, Newcastle disease virus, and Sendai virus) were separated by polyacrylamide gel electrophoresis. Glycoproteins were identified by the use of radioactive glucosamine as a carbohydrate precursor. The protein patterns reveal similarities among the three viruses. Each virus contains at least five or six proteins, two of which are glycoproteins. Four of the proteins found in each virus share common features with corresponding proteins in the other two viruses, including similar molecular weights. These four proteins are the nucleocapsid protein (molecular weight 56,000 to 61,000), a larger glycoprotein (molecular weight 65,000 to 74,000), a smaller glycoprotein (molecular weight 53,000 to 56,000), and a major protein which is the smallest protein in each virion (molecular weight 38,000 to 41,000).


Synthesis and cleavage of influenza virus proteins. The NWS strain of influenza virus grows rapidly in and kills the MDCK dog kidney cell strain. Within 1 to 2 hr, the virus inhibits host cell protein synthesis and for 3 to 4 hr more it directs the synthesis of influenza virus proteins at a rate about twice that of uninfected cell synthesis. The rates of virus ribonucleic acid (RNA) and protein synthesis reach a maximum within the first few hours after infection and then drop. Plaque assays exhibit a linear dose-response, indicating that only one virion is necessary for productive infection. We have confirmed earlier reports regarding the fragmented nature of the RNA genome of purified influenza virions. However, high resolution gel electrophoresis indicated that each size class of viral RNA is heterogenous, so that there are at least 10 and probably more fragment sizes of RNA in these virions. Repeated attempts to detect infectivity in preparations of extracted viral RNA were completely negative (over a 10(8)-fold loss of infectivity after extraction). Even infection of the "infectious" RNA-treated cells with intact, related, influenza viruses failed to support infectivity of the isolated RNA or to rescue a host range genetic marker of the RNA. Purified influenza virions exhibit only three major protein peaks based on separation according to molecular weights. These three major virion proteins are the only major virion proteins synthesized in infected cells. This is true throughout the infectious cycle from several hours after infection until the cells are dying. However, the molecular weight of these virion proteins differs slightly depending upon the cell type in which the virus is grown. No host membrane proteins are incorporated into the virions as they bud through the cell membrane. Pulse-chase labeling early after infection or prolonged chase experiments indicate that influenza virus proteins are cleaved from one or more precursor polypeptides. In fact, each of the three major peaks seems to be a heterogeneous mixture of polypeptides in various stages of cleavage. Peptide analysis confirms that the three major peaks share common peptides, but the exact precursor product relationships are not clear. There may be one or several precursor proteins. Also there could be overlapping messenger RNA molecules of varying length giving rise to polypeptides of various sizes and overlapping sequences. Late in infection, amino acid labeling shows a preponderance of internal nucleocapsid protein synthesis, indicating that either this protein is much more stable to cleavage in infection or it is made from a more stable messenger. There is no obvious relationship between virion RNA fragments and viral protein sizes, so these fragments may be artifacts.


Cells persistently infected with Newcastle disease virus. 3. Thermal stability of hemagglutinin and neuraminidase of a mutant isolated from persistently infected L cells. Data were obtained which indicated the possible cause of the defective elution from erythrocytes of the mutant virus (NDV(pi)) isolated from L cells persistently infected with the Herts strain of Newcastle disease virus (NDV(o)). The chicken erythrocyte receptors for the mutant and wild-type viruses were equally sensitive to the action of Vibrio cholera filtrate neuraminidase; this suggests that the failure of NDV(pi) to elute from chicken erythrocytes is not due to a specific neuraminidase-resistant receptor for this virus on the erythrocyte membrane. There was no difference in the enzyme content of the intact virions of NDV(o) and NDV(pi) when tested with a soluble substrate, indicating that the inefficient elution of NDV(pi) was not due to a reduced enzyme content. The neuraminidase activity of intact NDV(pi) virions was significantly more stable at 55 C than the enzyme of NDV(o) virions, whereas the dissociated enzymes of the two viruses were inactivated at the same rate. On the basis of these findings, it seems likely there is a structural difference between the two viruses. The neuraminidase protein of the mutant NDV(pi) may be incorporated into the viral envelope in such a manner that it is prevented from reacting with the substrate in the erythrocyte membrane, although it can react with a soluble substrate. The hemagglutinin activity of both intact and disrupted NDV(pi) was significantly more resistant to thermal inactivation than that of the wild-type NDV(o). This finding suggests a genetic difference in the hemagglutinin protein of the two viruses.


Lipid composition of purified vesicular stomatitis viruses. Methods are described for the production of vesicular stomatitis (VS) virus of sufficient purity for reliable chemical analysis. VS virions released from infected cells were concentrated and purified at least 150-fold by sequential steps of precipitation with polyethylene glycol, column chromatography, rate zonal centrifugation, and equilibrium centrifugation. The Indiana serotype (VS(Ind) virus) propagated in L-cells was found to contain 3% ribonucleic acid, 64% protein, 13% carbohydrate, and 20% lipid; the molar ratio of cholesterol to phospholipid was 0.6 or greater. Thin-layer chromatography revealed no unusual neutral lipids or phospholipids and gas-liquid chromatography revealed no unusual fatty acids incorporated into VS virions. The antigenically distinct New Jersey serotype (VS(NJ) virus) grown in L-cells showed a similar lipid profile except that the proportion of neutral lipids was larger than in VS(Ind) virus also grown in L-cells. This differences was less pronounced when the lipid composition of VS(Ind) and VS(NJ) viruses grown in chick embryo cells was compared, but VS(NJ) virus grown in either cell type always contained larger amounts of neutral lipids other than cholesterol than did VS(Ind) virus. The lipid composition of both VS(Ind) and VS(NJ) viruses grown in L-cells or chick embryo cells more closely resembled that of plasma membrane than of whole cells. A consistent finding was the relatively large amounts of phosphatidylethanolamine and sphingomyelin and the relatively small amounts of phosphatidylcholine in both VS viruses compared with uninfected whole L-cells and chick embryo cells or their plasma membranes. The methods available for isolation of plasma membranes were inadequate for conclusive comparison of the lipids of VS virions with the lipids of the plasma membranes of their host cells. Nevertheless, the data obtained are consistent with two hypotheses: (i) the lipid composition of VS viruses primarily reflects their membrane site of maturation, and (ii) the newly synthesized viral proteins inserted into cell membranes influence the proportions of phospholipids and neutral lipids selected for incorporation into the viral membrane.


Human renal allografts. The role of vascular injury in early graft failure.


Giant cell arteritis: including temporal arteritis and polymyalgia rheumatica.


Action and reaction.

Action and reaction.


A mental health program for industry.

A mental health program for industry.


The Occupational Safety and Health Act of 1970.


Self-understanding in counseling.

Self-understanding in counseling.


"Cri du Chat" syndrome. Report of a case.


Maternal deaths due to anesthesia.

Maternal deaths due to anesthesia.


Nutritional osteomalacia: a case report.


Recurrent convulsions in Cape Town children.


The prevention of complications in vaginal hysterectomy.


Pigmentation of the sole of the foot in Rhodesian Africans.


A newly prevalent type of beta hemolytic Streptococcus in Chicago.


A nationwide serum survey of Argentinian military recruits, 1965-1966. I. Description of sample and antibody patterns with arboviruses, polioviruses, respiratory viruses, tetanus and treponematosis.


Neutralizing antibody responses in the major immunoglobulin classes to yellow fever 17D vaccination of humans.


Venezuelan equine encephalomyelitis: surveys of human illness during an epizootic in Guatemala and El Salvador.


Vector-host studies of an epizootic of Venezuelan equine encephalomyelitis in Guatemala, 1969.


Hair trace metal levels and environmental exposure.


Unusual focal mesenteric venous thrombosis associated with contraceptive medication: a case report.


Long-term results of autogenous tissue coverings on prosthetic heart valves.


Infusion catheter sepsis: an increasing threat.


Transthoracic ligation of intercostal arteries for arteriovenous malformations of the spinal cord.


Use of a standard fatty meal as a test for fat absorption.


Mammary cancer subsequent to aspiration of cysts in the breast.


Immunotherapy for the patient with cancer.


Acid-base status of seriously wounded combat casualties. II. Resuscitation with stored blood.


Lung abscess. Initial and late results of medical therapy.


Ileostomy for granulomatous ileocolitis.


The kidney in acute rheumatic fever. Clinicopathological correlations.


Extreme hyperbilirubinemia.

Extreme hyperbilirubinemia.


Lymphosarcoma of the spleen. Results of diagnostic splenectomy in 11 patients.


Blood pressure in patients with spinal cord injury.


Carotid artery obstruction following LSD capsule ingestion.


Budd-Chiari syndrome caused by a right atrial tumor.


Culture of an Osler's node. A diagnostic tool.


Acromegaly, pheochromocytoma, toxic goiter, diabetes mellitus, and endometriosis.


Denaturation of globular proteins. 3. A comparative study of the interaction of urea with several proteins.


Human collagens: differences in glycosylated hydroxylysines in skin and bone.


Studies on complex formation between alpha-lactalbumin and the UDPgalactose-glucose galactosyltransferase of the bovine lactose synthesizing enzyme.


Crystalline insulin-ribonuclease. The presence of large molecular aggregates.


Role of O-acetyl groups in the interaction of Vi antigen with protein.


Large-scale preparation and preliminary characterization of human thrombin.


Hazards of deep-sea fishing.

Hazards of deep-sea fishing.


Absence from work in relation to length and distribution of shift hours.


The selection of juvenile entrants to mining.


Chronic manganese poisoning in the dry battery industry.


Cerebral blood changes in migraine.

Cerebral blood changes in migraine.


Effects of insulin from normal and diabetic human pancreas on RNA labeling in fibroblast cultures.


Studies on a cephalalgia extinction test.


The primary structure of bovine thyrotropin. I. Isolation and partial sequences of cyanogen bromide and tryptic peptides.


The primary structure of bovine thyrotropin. II. The amino acid sequences of the reduced, S-carboxymethyl alpha and beta chains.


Comparisons between the alpha chain of bovine thyrotropin and the CI chain of luteinizing hormone. Compositions of tryptic peptides, cyanogen bromide fragments, and carbohydrate moieties.


Activity of bovine pancreatic deoxyribonuclease A with modified amino groups.


Qualitative and quantitative studies of cytotoxic immune cells.


Comparisons of the specificities of cell-mediated and humoral immune responses. I. Cytolytic lymphocytes and plaque-forming cells following immunization with dinitrophenylated human IgG.


Depressed cellular and humoral hemolysin responses of rabbits injected intraperitoneally with mineral oil before immunization.


Anti-TNP antibody responses in vitro: augmented primary responses of carrier-primed spleen cells.


Immune response to alloantigens of thymus studied in mice with plaque assay.


Estrogenic status of menstruating and menopausal women assessed by cervicovaginal smears.


Comparative study of live, attenuated rubella virus vaccines during the immediate puerperium.


Postpartum rubella immunization. Results with the HPV-77 strain.


Rubella antibody determination among pregnant women in US military communities in Europe.


Trophoblastic disease. A correlative ultrastructural and biochemical study.


Hydatidiform mole in a clomiphene-related pregnancy. A case report.


Incipient microinvasive carcinoma of the uterine cervix. Morphology and clinical data of 22 cases.


Pelvic pneumoperitoneum in intersex disorders. Asymmetrical gonadal dysgenesis.


Genetic counseling. Secondary nondisjunction in partial trisomy 13.


Trisomy-D in cyclops. A case report.

Trisomy-D in cyclops. A case report.


Pseudo-pseudohypoparathyroidism and pregnancy. A case report.


Creation of a neovagina by the Frank nonoperative method.


Correlation of amniotic fluid estriol with fetal age and well-being.


One-day oral ampicillin-treatment of gonorrhea in young adults.


Vaginal aspirate studies in children. An atraumatic method.


Heparin for septic abortion and the prevention of endotoxic shock.


Lipid soluble weak organic acid buffers as "substrate" for pancreatic secretion.


Kinetics of Na inactivation in frog atria.


Long term liver blood flow measurements in rats under physiological conditions.


The electrocardiogram (ECG) and impulse conducting system (ICS) of the Asian musk shrew, Suncus murinus.


Secretory transmembrane potentials in acinar cells from the cat submandibular gland during perfusion with a chloride-free sucrose solution.


Correction of persistent truncus arteriosus.


Recurrent pleural effusion, protein-losing enteropathy, malabsorption, and mosaic warts associated with generalized lymphatic hypoplasia.


Cardiopulmonary bypass in hereditary spherocytosis: a case report.


Decortication of the heart for staphylococcal pericarditis.


Late results of oesophageal and oesophagogastric resection in the treatment of oesophageal cancer.


Lung scanning in carcinoma of the bronchus.


Cardiac output and arterial CO2 response during intermittent positive pressure breathing with oxygen. A comparison of patients with chronic airflow obstruction and controls.


Right heart pressures on bronchial asthma.


Transfer factor for CO during exercise in children.


Opacities of the middle and upper lobes in combination.


A search for mycoplasma infections in patients with chronic bronchitis.


Bronchial atresia with corresponding segmental pulmonary emphysema.


Diffuse malignant pleural mesothelioma and asbestos exposure.


Long-term result after operative correction of funnel chest.


Treatment of reflux strictures of the oesophagus by the Nissen-Rossetti operation.


Myocardial damage and valve replacements.


A new method of autologous fascia lata replacement for aortic valvular disease.


Histones and RNA metabolism in Ehrlich ascites cells infected with Maus-Elberfeld virus.


Suspended particulate air pollution. Relationship to mortality from cirrhosis of the liver.


Treatment of young delinquent boys with diphenylhydantoin sodium and methyphenidate. A controlled comparison.


The effects of blood donation on serum iron and hemoglobin levels in young women.


Effects of carbohydrate metabolism upon respiratory gas exchange in normal men.


Inherited propionyl-Coa carboxylase deficiency in "ketotic hyperglycinemia". Cultured fibroblasts from a young girl with ketotic hyperglycinemia were unable to oxidize propionate-(14)C to (14)CO(2), but oxidized methylmalonate-(14)C and succinate-(14)C normally. This block in propionate catabolism was shown to result from a lack of propionyl-CoA carboxylase activity. The carboxylase deficiency was not due to the presence of an intracellular inhibitor and it was not corrected by biotin, a known cofactor for the enzyme. Both of her parents' fibroblasts had approximately 50% of normal propionyl-CoA carboxylase activity. These results demonstrate that ketotic hyperglycinemia and propionicacidemia are the same disease, caused by a mutation of the propionyl-CoA carboxylase apoenzyme, which is inherited as an autosomal recessive trait. This enzymatic localization provides an explanation for the remarkable clinical and chemical similarity between ketotic hyperglycinemia and methylmalonicaciduria and offers a potential means of antenatal detection of this disorder.


Ethanol-induced hyperlacticacidemia: inhibition of lactate utilization. The effects of oral ethanol administration on blood glucose and lactate concentrations, lactate inflow and outflow rates, and lactate incorporation into glucose were investigated in eight human volunteers. Lactate incorporation into glucose, lactate turnover, and lactate inflow and outflow rates were determined during an 8 hr constant infusion of 100 muCi of lactate-U-(14)C. Ethanol was administered by mouth at hourly intervals, 60 ml of bonded whiskey initially and 30 ml/hr thereafter. Blood lactate concentrations increased precipitously after the administration of ethanol, reached a plateau within 120-180 min, and remained constant thereafter despite the continued administration of ethanol. Before ethanol, the lactate turnover rate was 0.76 mmoles/kg per hr +/-0.05 (SEM) and lactate inflow and outflow rates were closely balanced. During the administration of ethanol, the lactate inflow rate was unchanged, but the lactate outflow rate was significantly inhibited, decreasing to 50% of the inflow rate. Despite the continued administration of ethanol, equilibrium between lactate inflow and outflow was restored within 120-180 min and coincided temporally with establishment of a constant blood lactate concentration. Lactate oxidation was unaltered by ethanol, but lactate incorporation into glucose was significantly inhibited. Lactate incorporation into glucose was reduced within 30 min of the administration of ethanol, and nadir values were reached within 120-180 min. Lactate incorporation into glucose remained constant thereafter at rates that were only 30% of those observed in the absence of ethanol. The results of these studies indicate that ethanol-induced hyperlacticacidemia is due to decreased lactate disposal rather than increased lactate production.


Glucose-lactate interrelationships: effect of ethanol. The effect of ethanol on the interrelationship of lactate and glucose metabolism was investigated in eight human volunteers. Lactate and glucose kinetics and intervconversion rates were determined by the sequential administration of L-(+) lactate-U-(14)C and glucose-1-(14)C over an 8 hr period. After a 12 hr fast, the glucose turnover and recycling rates were 94.0 +/-3.8 (SEM) and 13.7 +/-1.1 mg/kg per hr, respectively. Approximately 50% of the glucose turnover or 40.7 +/-2.1 mg/kg per hr was converted to lactate, accounting for 50% of the lactate turnover rate. Lactate turnover and lactate conversion to glucose were 81.8 +/-6.2 and 16.7 +/-1.1 mg/kg per hr, respectively. Approximately 20% of the glucose turnover was derived from lactate under these conditions. During the administration of ethanol, the blood lactate concentration doubled and the lactate turnover rate declined slightly. Lactate conversion to glucose was markedly inhibited, decreasing from 16 to 5 mg/kg per hr, and the per cent of the glucose turnover derived from lactate decreased from 18 to 6. Despite the marked inhibition of lactate conversion to glucose, neither the blood glucose concentration nor the glucose turnover rate changed. Both glucose recycling and glucose conversion to lactate were decreased, indicating that ethanol inhibited peripheral glucose utilization. There was no difference in the degree of inhibition of lactate incorporation into glucose produced by ethanol when nonfasted subjects were compared with two subjects who had fasted for 48-72 hr despite the presence of hypoglycemia in the latter. These results indicate that starvation is not a prerequisite for ethanol inhibition of gluconeogenesis from lactate in humans but is necessary for the development of hypoglycemia. Inhibition of lactate incorporation into glucose in nonfasted subjects is probably masked by a concomitant increase in glycogenolysis which prevents hypoglycemia. Ethanol decreases glucose conversion to lactate as well as lactate conversion to glucose, thus inhibiting the Cori cycle.


Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude. To determine whether chronic exposure to hypoxia during adulthood produces alterations in the control of ventilation, measurements of the resting ventilatory response to hypoxia and hypercapnia, as well as ventilatory response to hypoxia during exercise, were carried out in a group of 10 long-term (3-39 yr) non-native residents of Leadville, Colo. (elevation 3100 m). A group of 8 subjects native to Leadville was also studied and 10 low altitude subjects of Denver, Colo. (elevation 1600 m) served as controls. Hypoxic ventilatory drive was measured as the shape parameter A of isocapnic VE-PA(o2) curves. In the non-native high altitude resident this parameter averaged 43% of the value for low altitude controls (P<0.05) denoting a diminished ventilatory response to hypoxia. The degree of attenuation was related to the length of time spent at high altitude. In the high altitude natives the parameter A averaged 9.6% of control (P<0.01). Similarly hypercapnic ventilatory drive as measured by the slope of the isoxic VE-PA(co2) lines was reduced in the non-native residents to 65% of control (P<0.05) and in the natives averaged 54% of control (P<0.01). In contrast with these findings at rest induction of hypoxia during exercise produced an increase in ventilation comparable to that in the controls in both groups of highlanders. Hence chronic exposure to hypoxia during adulthood in man results in marked attenuation of the ventilatory response to hypoxia at rest and this is a function of the length of exposure to hypoxia. This attenuation of the ventilatory response to hypoxia was associated with a decrease in hypercapnic ventilatory drive. The fact that hypoxic ventilatory drive was almost completely absent while hypercapnic drive was only partially reduced parallels closely the more important role of the peripheral chemoreceptors in mediating ventilatory responses to hypoxia than to hypercapnia. This suggests that the alterations in ventilatory control at altitude are due to failure of peripheral chemoreceptor function.


Erythropoietic protoporphyria: evidence for multiple sites of excess protoporphyrin formation. A patient with erythropoietic protoporphyria was studied to determine the sites of excess protoporphyrin formation. The patient's protoporphyrin was pulse labeled by the simultaneous administration of the precursors 2-glycine-(14)C and 3,5-delta-aminolevulinic acid-(3)H; delta-aminolevulinic acid preferentially labels the hepatic pool. Blood and feces were studied at intervals for the next 14 days. Protoporphyrin was extracted from erythrocytes, plasma, and feces, identified by thin-layer chromatography, and quantitated spectrophotometrically, and its specific activity was determined by liquid scintillation spectrometry. Analysis of the kinetic and isotopic data indicated at least two sources of protoporphyrin, one localized in the erythroid cells, a second in the liver. The liver was responsible for the majority of the excess protoporphyrin. This report thus provides evidence of a genetic porphyria exhibiting an abnormality of porphyrin biosynthesis in at least two tissues. We propose that the disease, erythropoietic protoporphyria, be renamed erythrohepatic protoporphyria.


On the mechanism of renal potassium wasting in renal tubular acidosis associated with the Fanconi syndrome (type 2 RTA). The mechanism of renal potassium wasting in renal tubular acidosis associated with the Fanconi syndrome (type 2 RTA) was investigated in 10 patients, each of whom had impaired proximal renal tubular reabsorption of bicarbonate as judged from a greater than 15-20% reduction of renal tubular bicarbonate reabsorption (THCO(3) (-)) at normal plasma bicarbonate concentrations. When the plasma bicarbonate concentration ([HCO(3) (-)]p) was experimentally increased to normal levels in three patients with a fractional potassium excretion (C(K)/C(in)) of less than 1.0 during acidosis, C(K)/C(in) and urinary potassium excretion (U(K)V/C(in)) increased strikingly and concurrently with a striking increase in urinary sodium (U(Na)V/C(in)) and bicarbonate (U(HCO3-)V/C(in)) excretion. When [HCO(3) (-)]p was increased to normal levels in two patients with a C(K)/C(in) of greater than 1.0 during acidosis and in whom U(Na)V/C(in) and U(HCO3-)V/C(in) were already markedly increased, C(K)/C(in) did not increase further. When [HCO(3) (-)]p was decreased to subnormal levels in a patient given ammonium chloride, U(K)V/C(in), C(K)/C(in), and U(HCO3-)V/C(in) decreased concurrently. In the six patients in whom [HCO(3) (-)]p was maintained at normal levels (oral alkali therapy) for 2 months or longer, C(K)/C(in) was directly related to the urinary excretion rates of sodium and bicarbonate, hence was directly related to the magnitude of reduction of THCO(3) (-) at normal [HCO(3) (-)]p; C(K)/C(in) was greater than 0.55 in all six patients and greater than 1.0 in four. In eight patients with classic RTA (type 1 RTA), proximal renal tubular reabsorption of bicarbonate was largely intact as judged from a trivial reduction of THCO(3) (-) at normal [HCO(3) (-)]p. When [HCO(3) (-)]p was either increased from subnormal to normal levels, or decreased from normal to subnormal levels, U(HCO3-)V/C(in) remained essentially constant, and U(K)V/C(in) did not change significantly. When correction of acidosis was sustained, U(HCO3-)V/C(in) remained a trivial fraction of that filtered, and C(K)/C(in) was consistently less than 0.55. These results provide evidence that renal potassium wasting in type 2 RTA is physiologically separable from that in type 1 RTA and in part the result of a reduction in the rate at which the proximal tubule reabsorbs bicarbonate and the distal delivery of supernormal amounts of sodium bicarbonate. With an increased stimulus to distal sodium reabsorption, indicated by the finding of hyperaldosteronism, delivery to the distal nephron of supernormal amounts of sodium with the relatively impermeant bicarbonate anion would be expected to increase intraluminal negativity in the distal nephron, and as a consequence, increase potassium secretion and promote renal potassium wasting.


Resting transmembrane potential difference of skeletal muscle in normal subjects and severely ill patients. The resting membrane potential difference (Em) of skeletal muscle was measured in 26 normal human subjects, 7 patients with mild illness, and 21 patients with severe, debilitating medical disorders. A closed transcutaneous approach to the muscle was made by needle puncture and the Em was measured utilizing standard Ling electrodes. Measurements revealed an Em of -88 +/-3.8 mv in healthy subjects and -89 +/-2.1 mv in patients hospitalized for minor medical problems. The mean Em in 21 in-hospital patients, judged to be severely ill clinically from a variety of causes, was -66.3 +/-9.0 mv. Open deltoid muscle biopsies were performed in 7 of the healthy subjects and in 13 of the severely ill group. Estimation of the intra-extracellular water partition was made by calculating the chloride space from the previously measured Em. Analysis of the muscle samples revealed no significant difference in the intra-extracellular potassium ratios of the two groups biopsied. Intracellular Na(+) concentrations were uniformly increased in the muscle samples of the severely ill subjects and averaged 42.3% higher than those of the normal subjects. The mechanisms which might account for the elevation of intracellular Na(+) and a depression of Em independent of changes in intra-extracellular K(+) ratios are discussed and it is suggested that this defect may be a generalized cellular abnormality which is a common quality of serious illnesses.


Capacity of human subjects to utilize keto analogues of valine and phenylalanine. Three adult human subjects were maintained for 7 days (period I) on a protein-free formula diet containing the minimum daily requirements of the eight essential amino acids plus 40 g glycine. During the last 5 days of this period, the average daily nitrogen balances for the three subjects were +0.52, +0.71, and +0.30 g, respectively. During the next 7 days (period II), valine was withdrawn from the diet, and the glycine ration increased by an equimolar amount. During the last 5 days of period II, average daily nitrogen balances declined to -1.82, -1.61, and -1.87 g, respectively. In the final period of 7 days (period III), the keto analogue of valine, alpha-ketoisovaleric acid, was added to the diet in a quantity equimolar to the minimum daily requirement of valine. During the last 5 days of this period, average daily nitrogen balances improved to -0.02, -0.18, and -0.83 g, respectively. Analogous experiments in three subjects involved the withdrawal from the diet of phenylalanine (period II) and replacement by its keto analogue, phenylpyruvic acid (period III). The average daily nitrogen balances were as follows: period I: +1.04, +0.96, and +0.53 g; period II: -1.45, -1.83, and -1.94 g; period III: +0.07, +0.11, and -0.52 g. The data demonstrate that man can convert alpha-ketoisovaleric acid and phenylpyruvic acid to the corresponding essential amino acids, valine and phenylalanine. The efficiency of these conversions is considerably less than 100%.