"Essential" hypernatremia due to ineffective osmotic and intact volume regulation of vasopressin secretion. A physiological explanation for sustained hyperosmolality was sought in a patient with histiocytosis. During 23 days of observation with only sodium intake regulated at 100 mEq daily, elevation (mean 310 mOsm/kg of water) and fluctuation (range 298-323) of the fasting plasma osmolality were recorded. The presence of endogenous vasopressin was indicated by the patient's ability to concentrate the urine to as high as 710 mOsm/kg of water with a creatinine clearance of 84 cc/min, and by dilution of the urine in response to alcohol. The failure of increasing fluid intake to as high as 6.2 liters daily to lower the plasma osmolality indicated that deficient fluid intake was not solely responsible for the elevated plasma osmolality. Hypertonic saline infusion during water diuresis resulted in the excretion of an increased volume of dilute urine. The water diuresis continued despite a rise in plasma osmolality from 287 to 339. An isotonic saline infusion initiated during hydropenia resulted in a water diuresis which continued despite a rise in the plasma osmolality from 303 to 320. Stable water diuresis induced during recumbency by either oral ingestion of water or intravenous infusion of normal saline was terminated by orthostasis and resumed with the return to the recumbent position. Antecedent alcohol ingestion blocked the antidiuresis of orthostasis. The data are interpreted as indicating impairment of the osmoreceptor mechanism as the primary cause of the hyperosmolar syndrome. They also indicate that vasopressin secretion was regulated primarily by changes in effective blood volume. Chlorpropamide was found to be an effective treatment for the syndrome.


A family with high-tonal objective tinnitus.


Methods for early detection of hearing loss in infants.


Sarcoma of the ethmoid in children.

Sarcoma of the ethmoid in children.


Primary lingual tuberculoma.

Primary lingual tuberculoma.


A pedunculated tonsillar lymphangioma.

A pedunculated tonsillar lymphangioma.


Antimicrobial therapy of gram-negative infections.


Ejection time before and after aortic valve replacement.


Radiographic heart size and left ventricular volume in aortic valve disease.


The effect of corrective surgery on left heart volume and mass in children with ventricular septal defect.


Evaluation of patients with tetralogy of Fallot and Potts anastomosis.


The clinical diagnosis of acute severe mitral insufficiency.


Intramuscular lidocaine in the therapy of ventricular arrhythmias.


Parachute mitral valve. Further observations and associated lesions.


Successful replacement of aortic and mitral valves with ball valve prostheses in a patient with rehumatic heart disease and SC hemoglobinopathy.


Postventriculotomy aneurysm in patients with idiopathic hypertrophic subaortic stenosis.


Dysrhythmic dilemmas in coronary care.

Dysrhythmic dilemmas in coronary care.


Acute cholecystitis with perforation into the peritoneal cavity.


Recurrence of varicose veins after the stripping operation.


Benign hypertrophy of the masseter muscles and mandibular angles.


A surgical follow-up and home visit program.


Tracheal replacement with autologous esophagus for tracheal stricture.


Trans-T-tube catheterization. Its use in the treatment of postoperative obstruction of the common bile duct.


Fistula between an interposed colon and the left ventricle.


An adjustable pulmonary artery band.

An adjustable pulmonary artery band.


Salmonella osteomyelitis of both hands and the hand-foot syndrome.


Splenosis. A disease or a beneficial condition?


Dissecting aneurysms in turkeys and man.


Pulmonary edema following blood transfusion reaction.


The asymptomatic mediastinal mass.

The asymptomatic mediastinal mass.


2-Keto-4-hydroxyglutarate aldolase of bovine liver. Schiff-base formation with 2-keto-4-hydroxyglutarate, pyruvate, and glyoxylate.


Studies on the allosteric properties of nuclear exoribonuclease from Ehrlich ascites tumor.


Henoch-Schönlein Purpura.

Henoch-Schönlein Purpura.


Dull in tooth and mind.

Dull in tooth and mind.


Effect of actinomycin D on Paget's disease of bone. Four patients with active Paget's disease were treated with the RNA inhibitor actinomycin D. Three were clinically improved after treatment; the fourth had multiple collapsed vertebrae and showed no symptomatic improvement. Striking changes took place in urinary calcium and hydroxyproline, in serum alkaline phosphatase, and to a less extent in serum calcium and phosphate. These studies are continuing and are being compared with the effects of mithramycin.


Tropical splenomegaly syndrome in Zambia: further observations and effects of cycloguanil and proguanil. Nineteen Zambian patients with the tropical splenomegaly syndrome and sinusoidal lymphocytosis on liver biopsy were studied. The association of macrobulinaemia with the tropical splenomegaly syndrome has again been confirmed. Sixteen patients were treated with antimalarials-12 with cycloguanil pamoate alone, 3 with cycloguanil and proguanil, and 1 with proguanil alone. Twelve patients were observed for periods of sufficient length for the drug effect to be assessed, and in 11 there was a good response in terms of decrease in spleen size.Cycloguanil pamoate may be of value both for prophylaxis and treatment in areas where tropical splenomegaly syndrome is endemic.


Systemic phycomycosis.

Systemic phycomycosis.


Termination of pregnancy with intra-amniotic hypertonic saline. Successful therapeutic abortion was performed consecutively by an intra-amniotic injection of hypertonic saline in 102 out of 110 patients in whom the size of the uterus corresponded with a pregnancy of 16 weeks or more.A spontaneous abortion of the fetus followed the injection alone in 92 of the cases, and the overall injection-delivery interval was 39.75 (range 11-98) hours. In 10 women intravenous oxytocin injection was used as an additional uterine stimulant because contractions were not established after 48 hours. Complete spontaneous expulsion of the placenta occurred in 71 cases, and evacuation of the placenta under general anaesthesia was required in the other 31.No major complication occurred among the 110 patients.


von Hippel-Lindau's disease and phaeochromocytoma.


Unusual complication of B.C.G. vaccination.


Halothane hepatitis--a preventable disease? Eleven patients with acute hepatitis following multiple anaesthetics with halothane have been seen at two hospitals during the last four years. Six had massive hepatic necrosis and died. Unexplained fever occurred in nine of the patients; two of these and one other had had previous episodes of jaundice after halothane anaesthesia. Thus, in ten patients the disease could have been avoided.


Minor gynaecological outpatient operations. Altogether 143 patients had minor gynaecological operations performed under general anaesthesia in the outpatient department. This method proved to be very acceptable to patient, gynaecologist, and anaesthetist. No complications occurred requiring admission to hospital, and the short recovery time confirmed the safety of early discharge from hospital. This procedure had a beneficial effect on the waiting list, and expensive beds were used more efficiently for major surgical cases. It is recommended that this procedure should be more widely practised, provided that the patients are adequately screened.


Primary coliform peritonitis.

Primary coliform peritonitis.


Epidemiology of the Hong Kong-68 variant of influenza A2 in Britain. Two influenza epidemics in Britain in 1968-9 and 1969-70, were due to the Hong Kong/68 variant of influenza A2 virus. The first epidemic was prolonged with low morbidity and mortality rates; the second was sharp with high rates. The difference between total morbidity and mortality in the two epidemics, however, was less than it appeared to be-the estimated excess morbidity and mortality due to all causes in 1969-70 was only about 50% greater than in 1968-9.Antibody studies showed that about one-quarter of two groups of adults investigated were infected in the first epidemic and about one-third in the second. After the two epidemics about one-third still had no antibody to the A2/Hong Kong/68 virus.


Analgesic nephropathy: clinical syndrome and prognosis. Over a five-year period 86 patients presented to a renal unit with a history of prolonged analgesic abuse and no other obvious cause of renal damage. Anaemia and peptic ulceration were common, and neurological states suggestive of chronic analgesic intoxication occurred in 22 patients. Thirty-two patients died during follow-up, but the prognosis was much better in patients who ceased abuse of compound analgesics, and improvement could occur even in advanced renal failure. While 84 patients had taken mixtures containing both aspirin and phenacetin, papillary necrosis was also found in two patients who had abused only aspirin, and when phenacetin was withdrawn from several leading compound analgesics, renal function continued to deteriorate in patients ingesting those preparations.


Septic gonococcal dermatitis.

Septic gonococcal dermatitis. The overall incidence in gonorrhoea of septic gonococcal dermatitis was found to be 1.9% (3% for the females and 0.7% for the males). In 23 patients the common presenting symptoms were arthritis or arthralgia and bouts of fever, but the characteristic skin lesions served as an early clue to the diagnosis, and Neisseria gonorrhoeae was isolated from the genitourinary tract or from the blood. With the use of immunofluorescent techniques gonococci were also found in smears prepared from the skin lesions. An immune response to gonococci was found with the complement fixation technique in 90% of the patients. The response to treatment with penicillin was prompt, with complete relief from joint pains and fever, usually within two to seven days. The skin lesions faded within a few days, but scars could be observed for up to four weeks.


Plasma propranolol levels associated with suppression of ventricular ectopic beats. The plasma propranolol levels associated with the abolition of chronic, stable ventricular ectopic beats have been studied. Racemic propranolol (DL) suppressed the ectopic foci at plasma levels of 40-85 ng/ml in eight patients, but levels of 70-200 ng/ml were unsuccessful in four patients. Dextro-(D) propranolol levels of 180-310 ng/ml were ineffective in four patients who had previously responded at levels of 60-75 ng/ml of racemic propranolol. The significance of the sympathetic nervous system in the genesis of ectopic beats is discussed. It is concluded that propranolol is clinically effective by virtue of its beta-adrenergic blocking activity.


Intracranial tuberculosis resembling Hand-Schüller-Christian disease.


Prolapse. I. Aetiology and diagnosis.

Prolapse. I. Aetiology and diagnosis.


Safety-pin swallowers.

Safety-pin swallowers.


Method of controlling epistaxis.

Method of controlling epistaxis.


The usefulness of an improved calcium electrode in the measurement of ionized calcium in serum.


Solubility of skin collagen in normal human subjects and in patients with generalised scleroderma.


Urinary and faecal excretion of metabolites of tyrosine and phenylalanine in a patient with cystic fibrosis and severely impaired amino acid absorption.


Dopa and 3-O-methyldopa in cerebrospinal fluid of Parkinsonism patients during treatment with oral L-dopa.


Acetic and benzoic acids in the urine of patients with chronic schizophrenia.


Proteolytic activity of serum bound with alpha 2-macroglobulin in diseases with reduced thrombin formation in clotting blood.


Automatic column chromatographic analysis of urinary and serum imidazoles in patients with histidinaemia and normals.


The alpha 1-antitrypsin and alpha 2-macroglobulin content and the protease-inhibiting capacity of normal and pathological sera.


Quantitative levels of the constituents of acid mucopolysaccharides and other carbohydrate polymers in dialyzed normal human urine.


Radioimmunoassay of human growth hormone using a charcoal-dextran separation procedure.


A simple and reliable method for the determination of oestriol in urine.


The acid glycosaminoglycan-degrading activity of normal human serum.


Further studies on multiple forms of peptidases in mammalian tissues including intestinal mucosa from children with treated and untreated coeliac disease.


The determination of trace elements in human fingernails by atomic absorption spectroscopy.


On the mode of action of reserpine on dopamine metabolism in the rat striatum.


Spontaneous umbilical fistula in granulomatous (Crohn's) disease of the bowel.


The effect of atropine on plasma gastrin response to feeding.


Ammonia absorption from the human colon. The role of nonionic diffusion.


The Micro-Kolmer complement fixation test in routine screening for soil ameba infection.


Long-term precision of the N2O method for coronary flow during heavy upright exercise.


Studies with ion exchange calcium electrodes. 3. The state of serum calcium in patients with cirrhosis.


Effect of prolonged bed rest on renal diluting capacity in normal man.


Comparison of cardiovascular responses to steady- and unsteady-state exercise.


Occurrence of organic heart disease in association with the Wolff-Parkinson-White syndrome--analysis of 29 cases.


Aortic valve replacement during treatment for active bacterial endocarditis.


Pediatric open heart surgery.

Pediatric open heart surgery.


Epidemiologic patterns of viral hepatitis in eastern Europe in the light of recent findings concerning the serum hepatitis antigen.


Precipitin responses to rubella vaccine RA 27-3.


Strategy of rubella vaccination.

Strategy of rubella vaccination.


Lead poisoning survey--Portland, Maine. July-August, 1970.


Hematuria in children.

Hematuria in children.


Epidemiology of viral and mycoplasmal agents associated with childhood lower respiratory illness in a civilian population.


Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice.


Exchange transfusion with citrated whole blood for disseminated intravascular coagulation.


An analysis of the results of therapy in 67 cases of the hemolytic-uremic syndrome.


Coagulation findings in the hemolytic-uremic syndrome of infancy: similarity to hyperacute renal allograft rejection.


Radiographic determination of total lung capacity in patients with cystic fibrosis.


Sporadic hypoglycemia: abnormal epinephrine response to the ketogenic diet or to insulin.


Hypohidrotic ectodermal dysplasia. A study of sweat pores in the X-linked form and in a family with probable autosomal recessive inheritance.


Urinary amino acid excretion in phenylketonuric, hyperphenylalaninemic, and normal patients.


Wilson-Mikity syndrome followed by "idiopathic" pulmonary hemosiderosis.


Self-mutilative behavior as a feature of the de Lange syndrome.


Pancreatitis, malabsorption, and IgA deficiency in a child with diabetes.


Neonatal thrombocytopenia and chorangioma.


The effect of chemotherapy on acute myelogenous leukemia in children.


Leukemia presenting as aplastic anemia.

Leukemia presenting as aplastic anemia.


Aspirin, platelets, and bleeding.

Aspirin, platelets, and bleeding.


Pseudomonas mastoiditis.

Pseudomonas mastoiditis.


Modified radical and radical mastoidectomy: long-term results.


Selection of the patient for conservation surgery of the larynx.


Symptomatic hyperirritable carotid sinus mechanism.


Rheoencephalography in the evaluation of the vertiginous patient.


The surgical management of the laryngeal complications of prolonged intubation.


Tuberculosis: a continuing problem.

Tuberculosis: a continuing problem.


Clinicopathological conference. Post-traumatic abdominal pain, icterus and anemia in 20-year-old man.


Influence of medium-chain triglycerides on steatorrhea--in maldigestion, malabsorption and primary exudative enteropathy.


Relative adrenal insufficiency.

Relative adrenal insufficiency.


Comparison of various methods for preparation of viral serological antigens from infected cell cultures.


The characteristic electrocardiogram of accidental hypothermia.


Microangiopathic hemolysis and thrombocytopenia related to penicillin drugs.


Aminocaproic acid treatment of prolonged hematuria following renal biopsy.


Cutaneous sporotrichosis. Beer, bricks, and bumps.


Preparing a child for hospital stay--a community project.


Clinical studies with an antigonadotropin-Danazol.


New findings relating to the gross and microscopic morphology of the uterine cervix in the rhesus monkey.


The public health investigator's expanding role.


Medical aspects of childhood lead poisoning.


Suicidal behavior among college students.


Retrospective survey of congenital rubella syndrome in the state of Washington, 1963-68.


Short-term group social service project for pregnant, indigent, unwed teenagers.


Shigellosis in Sitka, Alaska, 1968.

Shigellosis in Sitka, Alaska, 1968.


The economic costs of cigarette smoking.


Influenza in Los Angeles County, 1968-69.


Diabetes mellitus--present problems and new research.


Food information of homemakers and 4-H youths.


Amino acid balance in the treatment of phenylketonuria.


Food budgeting for adequate nutrition in Tehran, Iran.


Ground beef quality at the retail level.


In vitro responses of lymphocytes from cancer-bearing patients to autochthonous tumor tissues.


The role of beta-lipoprotein, cholesterol, and various sera in tissue culture intracellular lipidosis.


The cell site of the immunological defect in tumor-bearing mice.


Luteotropic and luteolytic effects of rat chorionic mammotropin.


A plaque assay for chick-embryo-lethal-orphan (CELO) virus.


Immunofluorescence in chronic TRIC infections of American Indians and Tunisians: influence of trauma on results of tests.


The control of gastrointestinal hemorrhage by selective mesenteric arterial infusion of vasopressin.


Comparison of methods for acceleration of small intestinal radiographic examination.


The radiological diagnosis of Strongyloides stercoralis enteritis.


A radiological sign in the diagnosis of enterogenous cysts.


Hemophilic pseudotumor of the stomach.

Hemophilic pseudotumor of the stomach.


Accentuation of celiac compression by the median arcuate ligament of the diaphragm during deep expiration.


Arteriovenous fistula, a complication of lumbar disk surgery. Angiographic demonstration.


Chylous lymphocyst.

Chylous lymphocyst.


Complications of hemophilic disorders affecting the renal tract.


Aortico-left ventricular tunnel.

Aortico-left ventricular tunnel.


Inferior subluxation of the humeral head: the drooping shoulder.


The clinical usefulness of magnification. Cerebral angiography.


Combined inferior vena cavography, iliac venography, and lung imaging with 99mTc albumin macroaggregates.


Traumatic intrapericardial herniation of the transverse colon masquerading as a pericardial effusion on the scan. Case report.


Effects of tri-ortho-cresyl-phosphate on spinal ganglia and peripheral nerves of chicken.


The perineurium as a diffusion barrier to protein tracers. Differences between mature and immature animals.


Studies on vascular permeability in peripheral nerves. IV. Distribution of intravenously injected protein tracers in the peripheral nervous system of various species.


Embryonal and postnatal development of mast cells in rat peripheral nerve.


The XY female.

The XY female.


Antigenicity of ovarian and cervical malignancies with a view toward possible immunodiagnosis.


Narcotic addiction in pregnancy.

Narcotic addiction in pregnancy.


Additional electron microscopic observations on two cases of Batten-Spielmeyer-Vogt disease. (Neuronal ceroid-lipofuscinosis).


Hepatic metabolic activity related to reproduction.


Increased blood-group A activity in urine of patients with renal disease.


Treatment of cervical cancer. A randomized study of operation and radiation.


Contraceptive use among single college students. A preliminary report. A 1968 survey of 446 college students ages 19-20 shows only 50% of the sexually active males and 60% of the females consistently use some contraceptive method.  Although students know of contraception, their motivation to use it may be weakened by difficulties in securing contraceptives, fear of detection by parents or others, and misunderstanding the risk of pregnancy.  Also, attitudes which sanction spontaneity as the appropriate circumstance for premartial intercourse make it difficult to take realistic action to prevent pregnancy.


Trends in laparoscopy.

Trends in laparoscopy.


Glycogen content of rabbit tubular genitalia from mating through implantation.


Immunohistochemical localization of IgE in asthmatic lungs.


The normal human liver cell. Cytochemical and ultrastructural studies.


Serum potassium changes after succinylcholine in patients with acute massive muscle trauma.


Hemodynamic and blood-gas effects of Innovar in patients with acquired heart disease.


Diagnostic features of fat embolism--results in six cases.


The effects of halothane anesthesia on reflex cardiovascular responses to simulated diving and the Valsalva maneuver.


Problems related to aldosteronism during cesarean section.


Subacute combined degeneration of the spinal cord. No association with vitamin B12 deficiency.


Infarction of spinal cord. Two cases of selective gray matter involvement secondary to asymptomatic aortic disease.


Subclinical "electrical status epilepticus" induced by sleep in children. A clinical and electroencephalographic study of six cases.


Anatomic relationships of the right subclavian vein. A radiologic study pertinent to percutaneous subclavian venous catheterization.


Familial lymphohistiocytosis of the nervous system.


Intestinal infarction. A complication of gastroenteritis and endotoxic shock in children.


Neurilemoma. A review of the literature with six case reports.


The value of preoperative abdominal arteriography.


Isolated left-sided vena cava and abdominal aortic aneurysm.


Paradoxical catheter embolism.

Paradoxical catheter embolism.


Chronic retroperitoneal hematomas in children.


Intrahepatic biliary disruption. Report of two cases occurring during use of balloon-tipped biliary catheters.


Symptomatic accessory lobe of the liver associated with absence of the left lobe.


Stenosing lesions of the colon secondary to pancreatitis.


Nonlinear kinetics of glutamate dehydrogenase. Studies with substrates--glutamate and nicotinamide-adenine dinucleotide.


Activity and fluorescent derivatives of aminotyrosyl trypsin and trypsinogen.


Tyrosyl and lysyl residues involved in the reactivity of catalytic and regulatory sites of crystalline beef liver glutamate dehydrogenase.


Isoelectric focusing behavior of bovine plasma albumin, mercaptalbumin, and beta-lactoglobulins A and B.


Preparation of bovine mercaptalbumin and an investigation of its homogeneity.


Optical activity of insulin. I. On the nature of the circular dichroism bands.


Altered conformational effects of phosphorylated lysine-rich histone (f-1) in f-1--deoxyribonucleic acid complexes. Circular dichroism and immunological studies.


Amebiasis--a symposium.

Amebiasis--a symposium. This is the transcription of the regular teaching conferences in infectious diseases held weekly at Harbor General Hospital, Torrance. These transcriptions are edited by Drs. J. A. Turner, I. Ziment and L. B. Guze.


Complications of rubella immunization in children. A rubella vaccine, prepared in dog kidney cell culture, was given to 4,734 primary school children in one California county in May, 1970. Adverse reactions of arthritis, arthralgia and paresthesia were reported two to eight weeks later. Paresthesia was a very prominent complaint and showed a peculiar diurnal pattern. Objective findings in a group of symptomatic children who came to medical attention were limited to tender, swollen, small joints. Rubella virus was isolated from throat swabs from two children with symptoms 38 and 43 days after immunization.A sample telephone survey of immunized and non-immunized children was conducted two to three months after the vaccination program to estimate the frequency, type, and distribution of reactions. Approximately 7 percent of inoculated children had symptoms subsequent to vaccination. Almost no reactions were found in the control group. There was a preponderance of girls affected, but symptoms appeared to be more severe in boys. The highest complication rate was found in the youngest age group. These reactions should be brought to the attention of medical groups and the public, but since these reactions are usually mild and self-limited, ongoing immunization programs need not be altered.


Metachronous development of regional enteritis of the colon in a patient with ulcerative colitis.


Clinical value of cadaveric renal homotransplantation. Cadaveric renal transplantation was found to be potentially applicable to 80% of a uremic population as observed over a six-year period. Death prior to presentation of a donor kidney occurred in 25%, 40% have received transplants and 15% are awaiting transplantation. Transplantation resulted in restoration of near normal renal function and homograft survival rates of 45% at one year, 40% at two years and 17% at four years. Failure of the therapeutic procedure resulted more often from death of the patient than from failure of the donor organ. Patient death was most frequently ascribed to complications of the immunosuppressive therapy, but cardiovascular accidents were also a significant cause. Early renal failure was due to hyperacute or acute rejection, while the cause of late renal failure remains unproved. Re-transplantation was effective treatment for late failure and, as a result, the four-year patient survival is nearly 40% compared to four-year initial kidney survival of 17%.


Diagnostic significance of physical signs produced during ECT.


Aseptic meningitis, Montreal, 1969: a clinical and laboratory study. During the summer and fall of 1969 an outbreak of aseptic meningitis occurred in Montreal and its environs. Forty-four patients were admitted to the infectious disease ward of The Montreal Children's Hospital in August, September and October. Half of the patients were in the age group 6 to 10 years. The ratio of males to females was two to one. Patients showed the typical signs and symptoms of aseptic meningitis, namely fever, vomiting, headache, neck stiffness and pleocytosis of the cerebrospinal fluid.Viruses were recovered from 19 (43%) of the 44 cases. The predominant virus in the outbreak was a non-hemagglutinating strain of echovirus 6. Other virus types isolated in the outbreak were echovirus 7, coxsackievirus A9 and coxsackievirus B4. Serological investigations confirmed the validity of the echovirus isolations and identified additional cases.


Crush injury of the thigh (Case P56).

Crush injury of the thigh (Case P56).


Antitrypsin deficiency.

Antitrypsin deficiency.


Glue sniffing: report of a fatal case.

Glue sniffing: report of a fatal case.


Toxic psychosis induced by Asthma-Dor.

Toxic psychosis induced by Asthma-Dor.


Urinary incontinence associated with thioridazine administration.


Position of the methionine residue in bovine neurophysin II.


Red cell metabolism in positive direct Coombs test after cephalothin therapy.


Medical versus surgical management of esophageal perforation.


Occlusive vascular disease in nonhemorrhagic stroke patients: clinical study of 145 patients.


Benign vascular shadows in chest X-rays.


Hand radioactivity after intravenous injection of 47Ca.: effect of age and femoral neck fracture.


Dermatologic surgery in aging skin.

Dermatologic surgery in aging skin.


Possible linkage between uncoiler chromosome Un 1 and amylase polymorphism Amy 2 loci.


Studies of enzymes connected with erythrocyte glutathione metabolism in a rural tropical population.


69,XYY sporadic triploidy in an adult.

69,XYY sporadic triploidy in an adult.


Father and son with karyotype 47,XY,?Yq-.


Cytological and cytogenetical studies on brain tumors. II. Hyperdiploidy, a rare event in human primary meningiomas.


Hereditary congenital coxa vara with dominant inheritance?


Endophthalmitis due to Toxocara.

Endophthalmitis due to Toxocara.


Persistent hypoglycaemia and severe hyponatraemia in a case of acute fatty liver of pregnancy.


Mental illness in Ireland--some further observations.


The incidence and importance of antibiotic-resistant bacteria in livestock in the Republic of Ireland.


Spontaneous electrical activity in muscle. Description of two patients with motor neurone disease.


Muscular pseudohypertrophy due to cysticercosis.


Conduction velocity in the ulnar nerve in hemiplegic patients.


A conspectus of research on protein requirements of man.


The morphogenesis of hydranencephaly.

The morphogenesis of hydranencephaly.


Facial fractures--associated injuries and complications.


Closure of large meningomyelocele defects by composite skin-muscle flaps.


Arthroplasty of the first carpometacarpal joint with a silicone implant.


Pleomorphic adenoma arising in the maxillary sinus. Case report.


Effectiveness of functional retraining for patients with quadriplegia.


Alpha and kappa electroencephalogram activity in eyeless subjects. Several reports have cast doubt on the cerebral origin of alpha and kappa electroencephalogram activity by charging that they are artifacts related to eye activity. Data are cited which eliminate the corneoretinal potential of the eyeball, tremor of the extraocular muscles, eye position, accommodation, and eye flutter as sources of alpha and kappa electroencephalogram activity. A subject with both eyes removed showed normal alpha and kappa electroencephalogram activity. Marked left-right differences in alpha activity were not found in one-eyed subjects whose eyes and extraocular muscles were completely removed on one side.


Partial purification of a beef adrenal delta-5-3-ketosteroid isomerase and studies of its mechanism of action.


Autotransplantation of the kidney in the treatment of renovascular hypertension.


Carcinoid tumors of the rectum in children: a review of the literature and report of a case.


Aortic debridement: long-term follow-up.


Changes in serum potassium and pH during clinical and experimental liver transplantation.


Chromosomal abnormalities of the E group and surgical anomalies in neonates.


Hiatal hernia in infants and children: results of surgical treatment.


Removal of intravascular and endobronchial foreign bodies by nonoperative snare technique.


The mischief: is it in drugs or in people?


Muscular torticollis: late results of operative treatment.


Popliteal artery occlusion by subadventitial pseudocyst: case report and summary of world literature.


Blood cysts of the cardiac valves of calves and cattle.


Advantages of the Beall valve prosthesis.


Isoniazid toxicity: reports of lactic acidosis and keratitis.


Relationships between ischemic heart disease and chronic diffuse pulmonary disease.


Intralobar bronchopulmonary sequestration with bronchial communication.


Echinococcosis of the heart.

Echinococcosis of the heart.


Cystic fibrosis of the pancreas--a comparison of the pulmonary manifestations in children and young adults.


Objective assessment of pericardial tamponade. Right heart catheterization at the bedside.


Triplication and quadruplication of the second sound.


Atrial flutter with 2:1 A-V conduction and Mobitz type II-like block in the left bundle branch.


Mechanically induced cardiac arrhythmia following open heart surgery.


Spontaneous disappearance of a calcified solitary pulmonary nodule.


Electrical and mechanical alternation in pericardial effusion.


Effect of the prone position on the phases of the cardiac cycle.


Intracardiac catheter as a foreign body of six years' duration resulting in endocarditis.


The Austin Flint murmur and the a wave of the apexcardiogram in aortic regurgitation.


Ventricular septal defect and ventricular aneurysm secondary to acute myocardial infarction. Report of four cases with successful surgical treatment.


Use of aortic valve homografts for aortic valve replacement.


Relationship between cardiac output and peripheral resistance in borderline hypertension.


Blood flow in the diabetic leg.

Blood flow in the diabetic leg.


Banding of the pulmonary artery. Results in 111 children.


Atrial pacing and exercise in the evaluation of patients with angina pectoris.


Recreational activity and career choice recommendations for use by physicians counseling physical education directors, vocational counselors, parents and young patients with heart disease. Ad Hoc Committee on Habilitation of the Young Cardiac, Council on Rheumatic Fever and Congenital Heart Disease, American Heart Association.


Diphenylhydantoin in the prevention of recurring ventricular tachycardia.


A brief rating scale for antidepressant drug trials.


Determinants of initial use of opioids.

Determinants of initial use of opioids.


Reported sleep characteristics: effects of age, sleep length and psychiatric impairment.


The psychotherapy of work.

The psychotherapy of work.


Action of alpha chymotrypsin, trypsin and certain specific activators on human plasminogen.


On the mechanism of acceleration of carboxypeptidase A activity.


Psychotherapeutic groups for alcoholics and relatives in an outpatient setting.


Genetic and constitutional influences on serum-uric-acid in a tropical rural population.


A profile of group psychotherapy practice among A.G.P.A. members.


The group as link between sick and healthy community.


The treatment of homosexuals in heterogeneous groups.


Use of multifamily counseling groups in treatment of male narcotic addicts.


A technique for overcoming resistance to group therapy in psychotic patients on a community mental health service.


Evaluation of group therapy with preadolescent girls: assessment of therapeutic effects based on Rorschach records.


An attempt to combine clinical and educational resources: a report on the first year's experience of a therapeutic school.


Spasmus nutans: a syndrome of auto-arousal.


Psychiatric aspects of cardiac surgery in a child.


The psychoanalysis of a young adolescent girl.


Conversion reactions in childhood: a clinical study on childhood neuroses.


The capacity to love: a possible reformulation.


A therapeutic approach to speech phobia: elective mutism reexamined.


Studies of thrombin formation with an insoluble derivative of prothrombin.


Deoxyribonucleic acid-dependent ribonucleic acid polymerase of Pseudomonas putida.


Bovine glutamate dehydrogenase. Loss of allosteric inhibition by guanosine triphosphate and nitration of tyrosine-412.


Spectrophotometric titration of tyrosine residues in human lysozyme.


Studies on human proinsulin. Isolation and amino acid sequence of the human pancreatic C-peptide.


Mechanisms of sulfur transfer catalysis. Sulfhydryl-catalyzed transfer of thiosulfonate sulfur.


Enzymatic modification of proteins. 4. Arginylation of bovine thyroglobulin.


Spontaneous fibrinolysis in pulmonary embolism. This study correlated levels of activated fibrinolysis with the presence, extent, and rate of resolution of angiographically documented pulmonary emboli. Pulmonary emboli demonstrable by angiography were associated with detectable fibrin split products in the serum of 24 of 25 patients. In the absence of increased fibrin split products, pulmonary emboli large enough to be demonstrated by angiography were found in only 2 of 25 positive pulmonary angiograms. Spontaneous resolution of pulmonary emboli could not be correlated with the the concentration or persistence of fibrin split products but did correlate well with the presence of a reversible precipitating cause. Thrombophlebitis in the absence of clinical evidence of pulmonary embolism was not associated with increased concentrations of fibrin split products in eight of nine patients. The one patient with increased fibrin split product concentration had evidence on lung scan of silent pulmonary embolism.


Liver galactose-1-phosphate uridyl transferase: activity in normal and galactosemic subjects. The kinetic characteristics of galactose-l-phosphate uridyl transferase have been determined in homogenates of human liver biopsies obtained from control subjects and in 50-fold purified enzyme preparations from liver obtained at autopsy. A standardized assay procedure employing linear kinetics was used to assess the enzyme activity in homogenates of liver biopsy specimens from five control subjects and four patients with congential galactosemia with demonstrated absence of the enzyme activity in red blood cells. Activity of control specimens ranged from 11.8 to 17.2 mmumoles of UDPgalactose formed per min mg of protein. Liver of two galactosemic patients, both Caucasian, possessed no detectable enzyme activity (less than 1-2% of normal). The tissue of two others, both Negro, who are known to be capable of metabolizing intravenously administered galactose, contained easily detectable enzyme at approximately 10% of the controls. No alternate enzymatic activity for formation of UDPgalactose was found in the liver of Negroes with galactosemia that was as active as the residual galactose-l-phosphate uridyl transferase. The data suggest that the residual liver enzyme activity accounts for the ability of Negroes with galactosemia to metabolize limited but significantly large quantities of galactose.


Hypoxemia in pulmonary embolism, a clinical study. The cause of hypoxemia was studied in 21 patients with no previous heart or lung disease shortly after an episode of acute pulmonary embolism. The diagnosis was based on pulmonary angiography demonstrating distinct vascular filling defects or "cutoffs." It was found that virtually all of the hypoxemia in patients with previously normal heart and lungs could be accounted for on the basis of shunt-like effect. The magnitude of the shunting did not correlate with the percent of the pulmonary vascular bed occluded nor with the mean pulmonary artery pressure. The shunts tended to gradually recede over about a month after embolism. Patients without pulmonary infarction were able to inspire 80-111% of their predicted inspiratory capacities, and this maneuver temporarily diminished the observed shunt. Patients with pulmonary infarcts were able to inhale only to 60-69% of predicted inspiratory capacity, and this did not reverse shunting. These data suggest that the cause of right-to-left shunting in patients with pulmonary emboli is predominantly atelectasis. When the elevation of mean pulmonary artery pressure was compared to cardiac index per unit of unoccluded lung, it fell within the range of pulmonary hypertension predicted from published data obtained in patients with exercise in all except one case. This observation suggests that pulmonary vasoconstriction following embolism is not important in humans, although these data are applicable only during the time interval in which our patients were studied and in patients receiving heparin.


Left ventricular function in acute myocardial infarction. Left ventricular catheterization was carried out in 40 patients with acute myocardial infarction. Left ventricular end-diastolic pressure (LVEDP) was elevated in 85% of the patients studied. In 14 patients with apparently uncomplicated infarcts, LVEDP averaged 15 mm Hg, and cardiac index (2.98 liter/min/m(2)), stroke volume (38.3 ml/m(2)), and stroke work (49.2 g-m/m(2)) were within normal limits. In 12 patients with clinical signs of left ventricular failure, LVEDP averaged 29.9 mm Hg, cardiac index was at the lower limit of normal (2.79 liter/min/m(2)), but stroke volume (31.6 ml/m(2)) and stroke work (37.3 g-m/m(2)) were reduced. In 14 patients with clinical signs of shock, LVEDP averaged significantly lower than in the heart failure group (21.1 mm Hg), but cardiac index (1.59 liter/min/m(2)), stroke volume (16.5 ml/m(2)), and stroke work (11.1 g-m/m(2)) were markedly reduced. A large presystolic atrial "kick" (average amplitude 9.5 mm Hg) was an important factor in the high LVEDP in the patients with heart failure but not in those with shock. The first derivative of left ventricular pressure was significantly lower in shock than in the nonshock group. Although right atrial pressure (RAP) and LVEDP were significantly correlated (r = 0.49), wide discrepancies in individual patients rendered the RAP an unreliable indicator of the magnitude of left ventricular filling pressure. THESE DATA SHOW THE FOLLOWING: (a) LVEDP is usually elevated in acute myocardial infarction, even in absence of clinical heart failure; (b) cardiac output apparently is supported by increased LVEDP and compensatory tachycardia; (c) in patients with shock, left ventricular function usually is markedly impaired, but inadequate compensatory cardiac dilatation or tachycardia could contribute to the reduced cardiac output in some individuals; (d) lower LVEDP in shock than in heart failure may represent differences in left ventricular compliance.


Continuing C3 breakdown after bilateral nephrectomy in patients with membrano-proliferative glomerulonephritis. Serum levels of complement components and of C3 nephritic factor (C3NeF) were measured serially in two patients with membrano-proliferative glomerulonephritis who were subjected to bilateral nephrectomy and maintained by peritoneal dialysis for 2 wk before renal transplantation. In both patients, low levels of C3 and high levels of preformed alpha 2D, a C3 breakdown product, were present before nephrectomy and remained essentially unchanged during the anephric period. With transplantation, C3 levels rose towards normal and alpha 2D disappeared from the serum. The serum of both patients contained detectable amounts of C3NeF, a factor which has been shown to react with a cofactor found in normal serum to form an enzyme, designated C3 lytic nephritic factor (C3LyNeF), which will cleave C3 to form the breakdown products, beta1A and alpha 2D. The level of C3NeF was high in one patient before nephrectomy, increased somewhat during the anephric period, and fell after transplantation. In the other patient, the C3NeF level was initially lower, remained relatively constant during the anephric period, and was not significantly affected by transplantation. In both patients, levels of C4 and C5 were either normal or elevated over the period of the study and bore no relationship to the C3 level. The following conclusions can be drawn from the data. The high levels of alpha 2D during the anephric period and the disappearance of this protein as C3 levels approach normal at the time of transplantation indicate that the low C3 levels were largely the result of C3 breakdown rather than diminished synthesis. The presence of C3NeF in detectable amounts in both patients suggest that C3LyNeF, formed by the reaction of C3NeF and cofactor, was responsible for the low C3 levels. Finally, the lack of effect of nephrectomy on C3, alpha 2D, and C3NeF levels indicate that the site of C3 breakdown was extrarenal and that C3NeF and cofactor are at least in large part of extrarenal origin.


Incorporation of L-leucine-14C into immunoglobulins by jejunal biopsies of patients with celiac sprue and other gastrointestinal diseases. Incorporation of L-leucine-(14)C into proteins and immunoglobulins in vitro was determined in jejunal biopsy specimens from normal volunteers, patients with celiac sprue before and after introduction of gluten into the diet, patients with Whipple's disease in remission, and patients with immune deficiency states. Values for incorporation of L-leucine-(14)C into total and soluble protein by biopsies from five celiac sprue patients on a gluten-free diet were within, or slightly above, the 95% confidence limits for control data. One patient with celiac sprue and with normal intestinal histology had a normal value for incorporation into IgA; the other four patients with flat mucosas had elevated values. In Whipple's disease in remission, values for incorporation into total protein and IgA were within the control limits, whereas incorporation into soluble protein was increased. Patients with hypogammaglobulinemia or IgA deficiency had normal or elevated values for incorporation into total and soluble proteins; in these cases, however, no incorporation into IgA was detected. Biopsies from the four celiac sprue patients studied revealed that with introduction of gluten into the diet (a) incorporation into total protein, soluble protein, or both, increased; (b) incorporation into IgA increased in all patients, and in two instances the increase was greater than the increase in incorporation into total protein; and (c) incorporation into IgM increased in all patients. The changes during gluten administration usually occurred before changes in gastrointestinal absorptive function or in concentration of IgA in serum could be detected. These results indicate that gluten challenge stimulates increased local intestinal synthesis of immunoglobulins in patients with celiac sprue. The reaction occurs within days and it is possible that it plays a primary role in the pathogenesis of the disease.


Etiology of hyperparathyroidism and bone disease during chronic hemodialysis. I. Association of bone disease with potentially etiologic factors. The present study was prompted by the observation that, in patients with chronic renal failure being followed at this center, renal osteodystrophy developed almost exclusively in those who were treated by chronic hemodialysis at home rather than in our center. A systematic comparison was made between the 10 patients with roentgenographic evidence of the bone disease and 18 patients without demonstrable bone disease. The two groups were similar in age, sex, nature of renal disease, and duration of dialysis. The mean duration of kidney disease was almost 2 yr longer in the patients without bone disease than in those with bone disease. Other significant differences related to where the hemodialysis was performed and to the calcium concentration in the dialysate (6.0-7.4 mg/100 ml in the hospital and 4.9-5.6 mg/100 ml at home). If the unknown factors related to where the dialysis was performed were of no consequence, the major factor contributing to the production of bone disease observed in these patients was the use of a dialysate with a calcium concentration less than 5.7 mg/100 ml.


Glucose and lipid homeostasis in the absence of human growth hormone. To clarify the role of insulin and growth hormone (HGH) in regulating substrate production for body fuel during prolonged starvation, 6 normal subjects and 10 HGH-deficient dwarfs were fasted for 6 days. Four of these dwarfs received HGH during the fast. Blood glucose concentration decreased a mean 15 mg/100 ml in both controls and HGH-treated dwarfs, but decreased 50 mg/100 ml in untreated dwarfs. The final level at which the blood glucose stabilized was significantly higher in the former two groups (65 +/-1.0 mg/100 ml and 88 +/-19 mg/100 ml, respectively, versus 39.0 +/-4.0 mg/100 ml in the untreated dwarfs). The decline in plasma insulin concentration showed a comparable pattern, decreasing from a similar basal level to 7.7 +/-0.4 muU/ml in controls, 8.8 +/-1.1 muU/ml in dwarfs treated with HGH, and to a significantly lower level of 3.8 +/-1.1 muU/ml in untreated dwarfs. When glucose concentrations were plotted against paired insulin values, the correlation in both dwarfs and normals was significant. In normals, no correlation existed at any time between plasma HGH levels and plasma concentration of either glucose or free fatty acid. Free fatty acid, beta-hydroxybutyrate, and acetoacetate increased respectively in normals to peak concentrations in plasma of 1.55 +/-0.11, 2.87 +/-0.23, and 0.77 +/-0.09 mmoles/liter. Untreated dwarfs had significantly greater values of all three (mean maximal concentration: FFA = 2.16 +/-0.17 mmoles/liter, beta-hydroxybutyrate = 4.11 +/-0.34 mmoles/liter, and acetoacetate = 1.16 +/-0.10 mmoles/liter). Values returned toward normal in HGH-treated dwarfs. The cahnges in plasma concentrations of beta-hydroxybutyrate and acetoacetate were not due to changes in renal excretion. In starvation, the relation between insulin on the one hand and glucose and free fatty acid on the other hand is maintained in the absence of HGH. However, the setting of blood glucose concentration at which this relation takes place is decreased in the absence of HGH. This results in a lower than normal insulin level and, consequently, in a higher than normal free fatty acid concentration.


Diurnal fluctuations in triglyceride, free fatty acids, and insulin during sucrose consumption and insulin infusion in man. Serial changes in circulating triglyceride, free fatty acids (FFA), insulin, and glucose have been measured in human subjects fed sucrose as the sole source of calories for 2- or 3-day periods. The sucrose was given either during the day with overnight fasting (19 subjects) or as continual 3-hour meals during the day and night (seven subjects). Insulin was infused overnight in five additional subjects on the day-feeding regimen to determine the effect on triglyceride concentration. The concentration of triglyceride increased during the study in all subjects, but there was a clear diurnal pattern in the response which was present even in the continual feeding studies. The rise in triglyceride occurred mainly overnight, and during the day there was frequently a fall in the concentration. The overnight increase was significantly less when insulin was infused. There were also diurnal fluctuations in FFA and insulin in both daytime and continual feeding regimens. The plasma FFA, like triglyceride, rose during the night and fell during the day while the insulin rose during the day and fell overnight. Separate statistical analysis of the daytime and overnight changes revealed that the changes in triglyceride were significantly but negatively correlated with changes in insulin during both periods. The changes in triglyceride and FFA were positively correlated during the day but not significantly related during the night. The data show that when sucrose is eaten for 2 or 3 days, there is a general increase in triglyceride concentration upon which are superimposed major diurnal fluctuations in the concentrations of triglyceride, insulin, and FFA. It is suggested that the highly significant inverse relationship between changes in triglyceride and insulin may be mediated through an effect of insulin on triglyceride removal.


Effects of thyroid disease on glucose oxidative metabolism in man. A compartmental model analysis. Glucose oxidation to CO(2) in man at the fasted, steady state has been investigated in normal, hypothyroid, patients by monitoring the specific activity of plasma glucose and expired CO(2) after intravenous injection of glucose-1-(14)C, glucose-6-(14)C, and sodium bicarbonate-(24)C in tracer amounts. Making certain stoichiometric assumptions about the oxidation of the C-1 and C-6 carbons of glucose to CO(2), the data are incorporated into a multicompartmental model describing the kinetics of plasma glucose, plasma bicarbonate, and the conversion of glucose to CO(2) by the hexose monophosphate pathway and all other series and parallel pathways which oxidize glucose carbon to CO(2) (EMP-TCA). This formulation separates the distribution kinetics of glucose and bicarbonate from the kinetics of glucose oxidation to CO(2). It allows the calculation of a minimal fraction (varphi(t)) of glucose irreversibly oxidized to CO(2) which is based entirely on the duration of the experimental data. This calculation is independent of the extrapolative implications of the model beyond the experimental interval and of the particular model chosen to fit the data. All modeling and data fitting were performed on a digital computer with the SAAM program. Based on a 300 min experiment the analysis suggests that in hypothyroidism there is a decrease in the rate of glucose metabolized irreversibly (rhoG). There is also a decrease in the minimal fraction (varphi(300)) which is completely oxidized to CO(2) by way of the EMP-TCA. rhoG and varphi(300) are 0.56 and 0.42 mmole/min respectively as compared to 0.89 and 0.50 mmole/min respectively in normals. However, the fraction of the C-1 of glucose metabolized irreversibly which undergoes oxidation to CO(2) by the hexose monophosphate pathway (Psi) is not different from normal (0.07 and 0.07 respectively). The hyperthyroid studies suggest that rhoG and varphi(300) are within the normal range (1.01 and 0.46 mmoles/min respectively as compared to 0.89 and 0.50 mmole/min respectively in normals). However, Psi is decreased to less than half the normal value (0.03 as compared to 0.07 in normals).


Rupture of the spleen during pregnancy.

Rupture of the spleen during pregnancy.


Renal potassium wasting in renal tubular acidosis (RTA): its occurrence in types 1 and 2 RTA despite sustained correction of systemic acidosis. IN TWO PATIENTS WITH CLASSIC RENAL TUBULAR ACIDOSIS (RTA) AND IN TWO PATIENTS WITH RTA ASSOCIATED WITH THE FANCONI SYNDROME, RENAL POTASSIUM WASTING PERSISTED DESPITE SUSTAINED CORRECTION OF ACIDOSIS: (a) during moderate degrees of hypokalemia, daily urinary excretion of potassium exceeded 80 mEq in each patient; (b) during more severe degrees of hypokalemia, daily urinary excretion of potassium exceeded 40 mEq in two patients and 100 mEq in another. These urinary excretion rates of potassium are more than twice those observed in potassium-depleted normal subjects with even minimal degrees of hypokalemia. The persistence of renal potassium wasting may have resulted in part from hyperaldosteronism, since urinary aldosterone was frankly increased in two patients and was probably abnormally high in the others relative to the degree of their potassium depletion. The hyperaldosteronism persisted despite sustained correction of acidosis, a normal sodium intake, and no reduction in measured plasma volume, and was not associated with hypertension; its cause was not defined. In the two patients with classic RTA, neither renal potassium wasting nor hyperaldosteronism could be explained as a consequence of a gradient restriction on renal H(+) - Na(+) exchange because the urinary pH remained greater than, or approximately equal to, the normal arterial pH or considerably greater than the minimal urinary pH attained during acidosis. The findings provide no support for the traditional view that renal potassium wasting in either classic RTA or RTA associated with the Fanconi syndrome is predictably corrected solely by sustained correction of acidosis with alkali therapy.


The prognostic value of EEG sleep recordings in carbon monoxide intoxication.


Erysipeloid infection of digits.

Erysipeloid infection of digits.


Selective reticulocyte destruction in erythrocyte pyruvate kinase deficiency. Radioisotope studies of bilirubin turnover, ferrokinetics, and red cell survival ((51)Cr) in a patient with erythrocyte PK deficiency have provided evidence for prompt reticulocyte sequestration and destruction by the reticuloendothelial system. More mature erythrocytes appeared to survive well despite their deficiency of PK. PK-deficient reticulocytes, dependent upon oxidative phosphorylation for ATP production, are exquisitely sensitive to cyanide- or nitrogen-induced mitochondrial inhibition. If oxidative phosphorylation is unavailable, ATP levels decline rapidly, producing alterations in the cell membrane which allow massive losses of potassium and water. The result is a shrunken, spiculated, viscous cell whose rheologic properties would favor its sequestration by the reticuloendothelial system. Those reticulocytes with particularly low levels of PK exhibit very low glycolytic rates and thus are uniquely reliant upon oxidative phosphorylation. Other reticulocytes, better endowed with PK activity, can meet the increased ATP requirements of young erythrocytes. Upon reaching maturity, such cells have diminished ATP needs and can, therefore, survive despite their enzyme deficiency.


Development and distribution of immunoglobulin-containing cells in the chicken. An immunofluorescent analysis using purified antibodies to mu, gamma and light chains.


Disseminated intravascular coagulation. Postpartum hemolytic-uremic syndrome with recovery of renal function.


Murmurs--innocent or otherwise? The innocent cardiac murmurs of childhood.


Borderlands of epilepsy. Current status of some problems in the borderlands of epilepsy.


The elastic constants of the human lens. 1. When the lens is spun around its antero-posterior polar axis in an apparatus designed for the purpose, high speed photography can be used to record its changing profile. By this method a variable radial centrifugal force can be applied to the lens which mimics the pull of the zonule.2. If the lens is not stressed at its centre beyond 100 Nm(-2) it behaves as a truly elastic body. When stressed beyond this limit visco-elastic strain is produced at its poles.3. The human lens has isotropic elastic properties at the extremes of life, but at the other times Young's Modulus of Elasticity varies with the direction in which it is measured.4. Young's Modulus of Elasticity of the lens varies with age, polar elasticity and equatorial elasticity, at birth being 0.75 x 10(3) and 0.85 x 10(3) Nm(-2) respectively, while at 63 years of age both are equal to 3 x 10(3) Nm(-2).5. A comparison of Young's Modulus of the young human lens with that of the rabbit and cat shows that the polar elasticity of the lenses of these animals was 5 times greater in the young rabbit, and 21 times greater in the adult cat. Equatorial elasticities of the rabbit and human lens were equal, while in the cat the equatorial elasticity was four times greater.6. A mathematical model showing the lens substance possessing a nucleus of lower isotropic elasticity than that of the isotropic elastic cortex surrounding it, accounts for the difference between polar and equatorial elasticity of the intact adult lens.7. The implications of these findings are discussed in relation to:(i) accommodation and the rheological properties of the lens;(ii) possible differences in the physical state of the lenticular proteins in the cortex and nucleus which may account for the senile variations in Young's Modulus of Elasticity in these regions of the lens;(iii) the loss of accommodation due solely to an increase in Young's Modulus of Elasticity of the lens between the ages of 15 and 60. This would amount to 44% of the total observed in vivo.


Pulmonary embolism prophylaxis in surgical cases.


Rubella-induced congenital defects and rubella immunization.


Acute iliofemoral venous thrombosis and polycythemia vera.


Complications of smallpox vaccination in Washington, 1968.


Lead poisoning.

Lead poisoning.


American children with reading problems can easily learn to read English represented by Chinese characters. With 2.5 to 5.5 hours of tutoring, eight second-grade inner-city school children with clear reading disability were taught to read English material written as 30 different Chinese characters. This accomplishment eliminates certain general interpretations of dyslexia, for example, as a visual-auditory memory deficit. The success of this program can be attributed to the novelty of the Chinese orthography and to the fact that Chinese characters map into speech at the level of words rather than of phonemes. It is proposed that much reading disability can be accounted for in terms of the highly abstract nature of the phoneme (the critical unit of speech in alphabetic systems) and that an intermediate unit, such as the syllable, might well be used to introduce reading.


Myocardial infarction associated with the use of oral contraceptives.


Muscular subaortic stenosis. Changing obstruction with atrioventricular dissociation.


The occurrence of Salmonella infection in market swine in Southwestern Ontario.


Pulmonary aspergillosis in a mare.

Pulmonary aspergillosis in a mare.


Bovine ketosis: principles of therapy.

Bovine ketosis: principles of therapy.


Diphallia in a Holstein bull.

Diphallia in a Holstein bull.


Alaria arisaemoides in Saskatchewan dogs.


A hereditary skeletal growth defect in purebred Alaskan Malamutes.


Transport and accumulation of triazenoimidazoles by L1210 cells.


The allergic family and pets.

The allergic family and pets.


The food processing front of the seventies.


Tenderizing effect of wine vinegar marinade on beef round.


Radiographic diagnosis of a tracheal neoplasm in a dog.


Epizootiology of tropical canine pancytopenia in Southeast Asia.


Paroxysmal atrial fibrillation in the dog.


Effects of vitamin A deficiency on the pituitary-gonad axis of the California quail, Lophortyx californicus.


The effects of 5-bromodeoxyuridine on yolk sac erythropoiesis in the chick embryo. The effects of the thymidine analog, 5-bromodeoxyuridine (BUdR), on the formation of red cells in the yolk sac of the chick embryo were examined. The prospective area opaca vasculosa from a definitive primitive streak embryo was excised, disaggregated, and deposited into a cell clump, and the cell clump was placed in organ culture. Hemoglobin synthesis is detectable after about 16 hr in culture. The formation of erythropoietic foci and incorporation of (55)Fe into heme were used to measure the extent of erythropoiesis. Exposure to 40 microg/ml of BUdR within 6 hr after explantation almost completely eliminated red cell formation; subsequent transfer to thymidine medium showed that the inhibition was reversible, and there was no histological evidence of analog toxicity. Between 6 and 12 hr after initiation of organ culture, the tissue became completely refractory to BUdR. DNA synthesis, as monitored by thymidine-(3)H and BUdR-(3)H pulses, was extensive both during and after the period of BUdR sensitivity. Hence, during both BUdR sensitive and insensitive periods the analog was incorporated into DNA of cells which had not yet synthesized hemoglobin. It is proposed that between 6 and 12 hr a crucial regulatory event for terminal differentiation is perturbed by the presence of BUdR in the chromosomes.


Development and chromosomal constitution of nuclear-transplants derived from male germ cells.


The production of congenital defects in rats using antisera.


Cleavage furrow formation in a telolecithal egg (Loligo pealii). II. Direct evidence for a contraction of the cleavage furrow base.


Regulative development in a spiralian embryo as shown by cell deletion experiments on the Acoel, Childia.


Nandrolone phenylpropionate, as a hysterotropic steroid.


Cat scratch disease. Report of a case presenting as an intra-oral mass.


Effect of a short period of fluoride ingestion on dental fluorosis in cattle.


Redescription of oocysts of the bovine coccidium Eimeria brasiliensis Torres and Ramos, 1939.


Gross and histopathologic changes of duck plague (duck virus enteritis).


In vitro cell association of Marek's disease herpesvirus.


Glycopeptides isolated from bovine submaxillary mucin.


Histone phosphorylation in synchronized mammalian cell cultures.


Studies on the functional properties of fish hemoglobins. II. The oxygen equilibrium of the isolated hemoglobin components from trout blood.


Human radiation exposures from nuclear power reactors.


Binding of water and solute to DNA.

Binding of water and solute to DNA.


Effect of housing conditions on corticosterone levels in mice.


PMR characterization of alfalfa and soybean ferredoxins: the existence of two ferredoxins in soybean.


Clinical aspects of fluorosis in horses.


Relationship of milking machine design and function to udder disease.


Intraocular cryptococcosis in two cats.

Intraocular cryptococcosis in two cats.


Eosinophilic leukemia in a cat.

Eosinophilic leukemia in a cat.


Patent ductus arteriosus in an aged dog.


A horseman's veterinary practice.

A horseman's veterinary practice.


Progressive retinal atrophy (rod dysplasia in the Norwegian Elkhound.


Lens-induced uveitis and secondary glaucoma in a dog.


Radiologic diagnosis of foreign body of tongue and salivary cyst in a dog.


Surgical closure of cleft soft palate in a dog.


Inclusions in neutrophils of cats with feline infectious peritonitis.


Arteriovenous fistula of the temporal branches of the external carotid artery in a dog.


Radiographic diagnosis of a hepatic cyst in a cat.


Congestive heart failure in dogs.

Congestive heart failure in dogs.


Injury to the cervical spinal cord in the dog.


Patent persistent urachus associated with urolithiasis in a cat.


Strychnine poisoning in horses.

Strychnine poisoning in horses.


Blood serum concentrations of various benzyl penicillins after their intramuscular administration to cattle.


Radiographic diagnosis of alveolar periostitis in the molar tooth of a horse.


Canine seizure disorders.

Canine seizure disorders.


Surgical correction of collapsed trachea in dogs.


Inapparent hip dysplasia.

Inapparent hip dysplasia.


Histochemical differentiation of Dirofilaria immitis and Dipetalonema reconditum.


Multiple myeloma in a cat.

Multiple myeloma in a cat.


Characterization of dogs with salivary cyst.


Dental anomalies in caribou, Rangifer tarandus.


A clinical, bacteriologic, and histologic survey of infertile cows.


Radiographic diagnosis of a bladder neoplasm in a dog.


Behavioral relationships between two sympatric voles (Microtus): relevance to habitat segregation.


Censuses of pinnipeds breeding on the California Channel Islands.


The evolutionary significance of the cervid labial spot.


Sexual dimorphism in beaver neutrophils.


Underwater copulation of the Weddell seal.


Dolphin feeding out of water in a salt marsh.


Mandibular variation with sex and age in white-tailed deer in Canada.


Carbohydrate metabolism in the isolated fetal rat heart.


Photocoagulation through the Goldmann contact glass. V. Further experience with a quasi-continuous ruby laser source: long-term observations of clinical efficiency.


The release of high molecular weight DNA from a mammalian cell (L-5178Y). Attachment of the DNA to the nuclear membrane.


Characterization of the mitochondrial DNA of the slime mold Physarum polycephalum.


The inhibition of deoxyribonuclease I by hydroxybiphenyls.


Genu recurvatum, uterine retroversion and dysmenorrhea. Relation to fetal position.


Histone acetylation in synchronized mammalian cell cultures.


Late onset of disease in congenital toxoplasmosis.


Human ecology and medical care.

Human ecology and medical care.


Olfactory coding in olfactory bulb and medial forebrain bundle of normal and castrated male rats.


Further leptospiral isolations in the Sepik district, Territory of Papua and New Guinea.


Female masturbation--more common than we think.


Some effects of organic acid supplementation on utilization of ammonium compounds by three pathogenic fungi.


Paradoxical effects of estrogen on brain differentiation.


Slow inward current and action potential in cardiac Purkinje fibres. The effect of Mn plus,plus-ions.


The dependence of cardiac contraction on depolarization and slow inward current.


Measurements of the critical PO2 of renal mitochondria.


Experiments concerning the transfer specificity of brain extracts in the taste discrimination of goldfish.


Transfer of taste preference from trained goldfish (Carassius auratus) into untrained recipients.


Reference Centre for Avian Malaria Parasites.


Electron microscope study on neural crest cells and adjoining cells in mice, with special reference to the melanosome formation.


Electron microscope studies on the endocrine cells of the human gastric fundus.


Application of the scanning electron microscope to the study of the fine distribution of the blood vessels.


Fine structure of autonomic ganglion in the chicken pancreas.


Neurologic disease in reindeer (Rangifer tarandus tarandus) introduced into Ontario.


Range expansion of Brewer's blackbird: phenetics of a new population.


Dispersal and range expansion by the cardinal: an analysis of banding records.


Aspects of histophysiology of the spermathecal gland of Sitophilus granarius (L.) (Coleoptera).


Fascioloides magna (Bassi, 1875) Ward, 1917 (Trematoda) in woodland caribou, Rangifer tarandus caribou (Gmelin), of northeastern Quebec, and its distribution in wild ungulates in Canada.


The number of immunologically activated cells after repeated immunization. (A mathematical model).


Acute effect of endotoxin on nucleic acid content of the mammary gland.


Chloride ion activity electrode for the detection of abnormal milk.


Determination of aflatoxins B1 and M1 in milk.


Ethanol intoxication in calves fed certain milk replacers.


Biopsy of liver, adipose tissue and mammary gland of lactating cows.


Alterations in blood and milk lipids produced by administration of triton WR-1339.


Disc electrophoresis of Weber-Edsall extract and actomyosin from skeletal muscle.


Body weights of dairy cattle with and without access to water.


Growth of multicell spheroids in tissue culture as a model of nodular carcinomas.


Recovery of Moloney murine sarcoma virus added to bovine milk.


Radioautographic analysis of 7,12-dimethyl-benz(a)anthracene-3H incorporation and cell survival of Syrian hamster embryo cells during exposure to nucleic acid inhibitors.


Triglycerides in wheat germ as chemical stimuli eliciting aggregation of the confused flour beetle, Tribolium confusum (Coleoptera: Tenebrionidae).


Vitamin A content of the livers of huskies and some seals from Antarctic and subantarctic regions.


Organic mercury identified as the cause of poisoning in humans and hogs. Atomic absorption spectrophotometry and neutron activation analysis showed the presence of mercury in organic extracts of seed grain and in tissues of hogs fed the contaminated grain. Mercury was also found in the urine, serum, and cerebrospinal fluid of humans who ate the contaminated pork. Mass spectral analysis confirmed the presence of organic mercury. This paper reports the first documented episode of indirect mercury poisoning in humans in the United States caused by the ingestion of contaminated meat from animals that had consumed mercury in their food supply.


Activity change as the cause of apparent aversiveness during prolonged hypothalamic stimulation.


DNA fragmentation in a clonal line of rat pituitary tumor (GH1 strain).


Students' perceptions and concerns during their first year in medical school.


Separation of the constituents of Cerbera thevetia (yellow oleander) by thin layer chromatography.


Purification of a human placental cholesteryl ester hydrolase.


Short adrenergic neurons innervating the female urethra of the cat.


Plasma and adrenal corticosterone levels during the different phases of the sexual cycle in normal female rats.


Quantitation of fibrinolytic agents released in tissue culture.


Cobra venom factor-induced activation of the complement system: developmental, experimental and clinical considerations.


An enzyme histochemical study of antibody production by single cells.


Pituitary responsiveness to purified luteinizing hormone-releasing hormone (LH-RH) at various stages of the estrous cycle in sheep.


Effect of subcortical lesions on shock-induced aggression in the rat.


Effect of dietary unsaturated fatty acids and stage of lactation on milk composition and adipose tissue in swine.


On fighting in mice: ontogenetic and experiential determinants.


Modification of copulatory behavior in the female rat following olfactory bulb removal.


ECS as a punishing stimulus: dependency on retrograde amnesia, duration of anterograde amnesia, and intensity of pain.


Effects of dietary protein on blood, urine, and milk composition.


Craniopharyngeal canal and pharyngeal hypophysis in the siamang gibbon (Symphalangus syndactylus).


Development of Eimeria alabamensis from cattle in mammalian cell cultures.


Immunological memory in vitro.

Immunological memory in vitro. The immune responses to sheep erythrocytes of mouse spleen cell suspensions from immune and nonimmune donors were compared in vitro. In vivo immunity was only transiently reflected in vitro, and 8 wk after in vivo immunization the responses of cultures from immunized and nonimmunized mice were virtually identical. There appeared to be two mechanisms for an antibody response to sheep erythrocytes. The first was responsible for the early primary response and is unmodified in the immune animal though contributing little to subsequent in vivo responses due to its suppressibility by specific antibody. The second was expressed in the in vivo secondary response but not on in vitro challenge of spleen cells from mice immunized many weeks previously; spleen cell cultures from such immune mice, freed from the antibody of the in vivo environment, once again demonstrate a pure primary-type response.


Individual versus standardized hierarchies in the systematic desensitization of snake-avoidance.


Inhibition of deoxyribonucleotide synthesis by pyridine carboxaldehyde thiosemicarbazones.


Selective metabolic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea upon de novo purine biosynthesis.


Progestin secretion by the ovary in lactating rats: effect of LH-antiserum, LH and prolactin.


Action of exogenous progesterone and estrogen on behavioral estrus and luteinizing hormone levels in the ovariectomized ewe.


Inhibition of thyroid iodide peroxidase by hydrazines and NSD-1055 (4-bromo-3-hydroxybenzyl-oxyamine).


Iron, anaemia, and old age.

Iron, anaemia, and old age.


Iron absorption from food.

Iron absorption from food.


Effect of calcium and magnesium on the morphology and growth pattern of L-M cells.


Effect of thymus-derived lymphocytes on amount and affinity of anti-hapten antibody.


Accredited Dental Assisting Programs. 1971 List from ADA Council on Dental Education.


L-benzylalanine as a model amino acid for the study of accumulation diseases.


Influence of the branched-chain volatile fatty acids and phenylacetate on rminal microorganisms and nitrogen utilization by steers fed urea or isolated soy protein.


Eccentric fixation managed with inverse prism.


Outbreak of swine malformations associated with the wild black cherry, Prunus serotina.


Circular dichroism studies of biologically active growth hormone preparations.


Congenital heart disease in 56,109 births. Incidence and natural history.


Spastic striated external sphincter and urinary tract infection in girls.


A phosphoenzyme intermediary in phosphoglycerate kinase action.


Goitrogenic effects of a corn silage--soybean meal supplemented ration.


Primary progressive multifocal leukoencephalopathy. A case report.


Vitamin A: probe of immune complement reactions. II. Enhancement of human complement hemolysis.


Studies on a phytohemagglutinin from the lentil. 3. Reaction of Lens culinaris hemagglutinin with polysaccharides, glycoproteins, and lymphocytes.


Control mechanisms of adenine nucleotide metabolism of ascites tumor cells.


Comparative studies on the modification of specific disulfide bonds of trypsinogen and chymotrypsinogen.


Aeromonas aminopeptidase. Improved isolation and some physical properties.


Polypeptide hormone interaction. I. Glucagon detergent interaction.


Phosphate transport, nucleotide pools, and ribonucleic acid synthesis in growing and in density-inhibited 3T3 cells.


Runoff, solid wastes, and nitrate movement on beef feedlots.


Erysipelas in the guinea-fowl.

Erysipelas in the guinea-fowl.


Inter- and intramolecular interactions of alpha-lactalbumin. X. Effect of acylation of tyrosyl and lysyl side chains on molecular conformations.


The synthesis of ribonuclease A.

The synthesis of ribonuclease A.


Antiändrogenic-like effect of polychorinated biphenyls in cockerels.


Some aspects of reproductive efficiency in sheep.


Two cases of grass sickness at a thoroughbred stud.


Fits in the dog.

Fits in the dog.


The incidence of tetanus.

The incidence of tetanus.


The pathology of the placenta in ovine abortion due to toxoplasmosis.


Poisoning from insecticides.

Poisoning from insecticides.


Changes in pig production in Britain and their effect on the veterinary profession.


The influence of pasture management on stocking and nutritional value.


New developments in forage conservation.


The nutritional assessment of pasture.

The nutritional assessment of pasture.


Problems associated with intensively managed grassland.


Epidemiology of parasitic gastro-enteritis in sheep.


Some observations on the epidemiology of fascioliasis in relation to the timing of molluscicide applications in the control of the disease.


Metabolic disorders of cattle and sheep.


The pathology of the foetus in ovine abortion due to toxoplasmosis.


The organisation of a farmers' "do-it-yourself" bovine insemination service.


Fatal laburnum poisoning in a dog.

Fatal laburnum poisoning in a dog.


Uncommon presentation of an anterior mediastinal mass.


Newcastle disease.

Newcastle disease.


The use of bromocyclen for the control of the cat flea (Ctenocephalides felis).


A report of an unusual nervous condition in poultry in northern Ireland.


Smoking habits of physicians and preventive care practices.


Applications of a gas-liquid chromatographic method for amino acid analysis. A system for analysis of nanogram amounts.


Determination of metabolites of tyrosine and of tryptophan and related compounds by gas-liquid chromatography.


Electrophoretic heterogeneity of crystalline insulin: a comparison of methods.


More on prescribing medication for pediatric patients.


Metabolic effects of exchange transfusions. I. Effect of citrated and of heparinized blood on glucose, nonesterified fatty acids, 2-(4 hydroxybenzeneazo) benzoic acid binding, and insulin.


Therapeutic abortion in California. Effects of septic abortion and maternal mortality. The impact of the reformed California abortion law, passed in November 1967, is investigated.  The law allows interruption of pregnancy in the presence of substantial risk of grave impairment to the mental or physical health of the mother.  Septic abortions (complete or incomplete abortion in a patient whose gestation is less than 20 weeks; duration and whose temperature is greater than 100.4 degrees F for more than 4 hours) per 1000 deliveries at San Francisco General Hospital  fell from 69 in 1967 to 22 in 1969.  The total number of abortions rose from less than 100 per 1000 births in 1968 to more than 250 in 1969.  Maternal deaths due to abortion decreased in California per 100,000 live births from 8 to 5 to 3 in 1967, 1968, and 1969.  Maternal deaths due to other causes remained relatively fixed in incidence.  Maternal deaths have decreased much more markedly in the San Francisco Bay area, where many more therapeutic abortions have been performed, than in the Los Angeles Area, where relatively few therapeutic abortions have been performed.  The decrease in septic abortion seems to represent a trend toward decrease in the number of illegal abortions.


Reporting of neonatal deaths.

Reporting of neonatal deaths.


I. Minor tranquilizers.

I. Minor tranquilizers.


Vaccination response of parentally immune chicks after yolk-sac inoculation of the embryo with inactivated Newcastle Disease Virus.


Prostaglandins.

Prostaglandins.


Effect of protein levels and opaque-2 corn on nitrogen metabolism in the sow and litter during the first and second lactation periods.


Isolation and identification of Marek's disease herpesvirus by yolk-sac inoculation method.


Effect of protein levels and opaque-2 cornon sow milk composition.


Relationship of nitrogen source to certain blood compents and nitrogen balance in the equine.


Relation of cardiovascular changes in fighting to emotion and exercise. 1. To obtain evidence on the relative importance of exercise and emotion in the cardiovascular changes of fighting in the cat, the changes during fighting were compared with changes during a mild non-emotional exercise (walking on a treadmill at low speed), and during confrontation without fighting (preparation for fighting), an emotional condition accompanied by no or very little motor activity.2. The direction of change of all variables we measured, iliac and mesenteric flows and conductances, total peripheral conductance, heart rate, cardiac output and blood pressure, was similar in both fighting and exercise.3. Some of the cardiovascular manifestations of preparation for fighting were very different from those of motor activity. These were iliac vasoconstriction, a fall in cardiac output, and often a strong bradycardia, all of these changes being in the opposite direction to changes during exercise and fighting.4. It is suggested that the changes during preparation for fighting represent the cardiovascular manifestations of an emotional state, and that during fighting these manifestations are superseded and masked by changes due to motor activity.


The effects of ions on the transuterine endometrial potential difference.


Risk of visual detection and pursuitby a predator and the selective advantage of flocking behaviour.


Advertising and abuse of drugs.

Advertising and abuse of drugs.


Binding of deoxyribonucleic acid by cell walls of transformable and nontransformable streptococci. Cell walls isolated from competent streptococci (group H strain Challis) were shown to bind more homologous and heterologous deoxyribonucleic acid (DNA) than noncompetent walls. Heat- and alkali-denatured DNA was not bound by either wall preparation. Pretreatment of cell walls with cetyltrimethylammonium bromide sharply increased the binding of DNA but did not increase transformation of whole cells. Pretreatment of the walls with either sodium dodecylsulfate, deoxyribonuclease and ribonuclease, or with crude competence-provoking factor did not affect the binding of DNA. Antiserum prepared against whole competent cells completely blocked transformation and also inhibited DNA binding to competent cell walls. Adsorption of this antiserum with competent Challis cells removed its blocking action for both binding and transformation. Pretreatment of walls with trypsin and Pronase destroyed their ability to bind DNA. Trypsin treatment also blocked transformation in whole cells. The transforming activity of DNA bound to cell walls was found to be protected from deoxyribonuclease action. Significant differences were observed in the arginine, proline, and phenylalanine content of competent and noncompetent walls. With few exceptions, the amino acids released from competent cell walls by trypsin were several-fold greater than from noncompetent walls. The results indicate that (i) two binding sites exist, one in competent cells only and essential for subsequent transformation, and a second, present in all cells, which is not involved in transformation; (ii) both sites are protein in nature; (iii) the transformation site is blocked by antibody; and (iv) the competent cell wall possesses tryptic-sensitive protein not present in the noncompetent wall.


Analysis of "street drugs".

Analysis of "street drugs".


Activity, motor coordination and attention: individual differences in twins.


Drug abuse education--a challenge.

Drug abuse education--a challenge.


The use of bephenium hydroxynaphthoate for the treatment of human infections with Ternidens deminutus Railliet and Henry 1909.


The localization of morphogenetic factors in uncleaved eggs of Dentalium.


Isolation of the lymphoagglutinating fractions of phytohaemagglutinin (PHA) from phaseolus vulgaris and characterization of their biological properties.


The fine structure of basidiospores of Panaeolus campanulatus (L.) Fr. revealed by freeze-etching.


Release of viral hemagglutinin and nucleocapsid components after disruption of Sindbis virus with ether.


Differentiation of human mycoplasma using gas chromatography.


Amino acid sequence of the subunits of ovine pituitary interstitial cell-stimulating hormone.


Mycotoxins in Aspergillus.

Mycotoxins in Aspergillus.


The surface structure of saprophytic and parasitic dermatophyte spores.


Influence of some factors on the growth and development of adiaspores of the fungus Emmonsia crescens Emmons et Jellison 1960.


Fungi of certain stored vegetable seeds in relation to pre- and post-emergence effects.


Chemical and physiological changes in filamentous fungi during autolysis. X. Changes in the concentration of polyol in autolysin cultures of several fungi.


Private camp nursing--wht is it?

Private camp nursing--wht is it?


Nematophagous fungi of agricultural soils. I.


Preventive measures to minimize accidents among the elderly.


Human relations in our changing society.


Childhood splenectomy: indications for and results from.


Placental transfer of iron in the rabbit.


In-vitro studies with ancrod ('Arvin').

In-vitro studies with ancrod ('Arvin').


Digestion of concentrates in sheep. 1. The effect of increasing the concentration of soya-bean meal in a barley diet on apparent disappearance of feed constituentsalong the digestive tract.


Blindness in Friesian cows in Iran.

Blindness in Friesian cows in Iran.


Comparison of various serological tests on the milk of sheep in relation to the isolation of Brucella melitensis.


The nematode fauna of the Chillingham Wild White Cattle.


A note on spheroplasts and mycoplasma in synovial fluid.


Spermatotoxicity of immune sera in human infertility.


Effect of a single low dose of estrogen on ovulation, pregnancy, and lactation in immature rats.


Sterilization by cryosurgery a report of animal fertility studies.


The demonstration of chromosomes in the rabbit blastocysts.


Suppression of cervical mucus during clomiphene therapy.


Stimulation of L-cystine-aminopeptidasactvity by hormonal steroids and steroid-analogs in the hypothalamus and other tissues of the female rat. The stimulation of L-cystine-aminopeptidase activity by estrogens in the hypothalamus and other tissues of the rat was investigated by a colorimetric method.  It was shown that after injections of estrogens and progestins, there was a dose-dependent increase of enzyme activity in the hypothalamus and the paleopallium, but not in the other areas of the rat brain and other tissues.  Cyclofenil and epimestrol were found to behave like conventional estrogens in this respect, while stilbestrol, ICI 46,474, and clomiphene were inactive.  Testosterone, pregnandiol, corticosterone, and dexamethasone were not effective in enhancing L-cystine-aminopeptidase activity under the experimental conditions used.  It is suggested that this organ-specific stimulation of enzyme activity plays a role in the regulation of gonadal function.


Potentiated reagin response to egg albumin in Nippostrongylus brasiliensis infected rats. II. Time course of the reagin response.


Which AB scale? A comparative analysis of several versions.


Subunit conformation and catalytic function in rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase.


Analysis of immunological memory in terms of increased PFC responsiveness and increased focus-forming capacity.


The incidence of oestrus during lactation in Finnish Landrace, Dorset Horn and Finn-Dorset sheep.


Effect of maternal age on postimplantation reproductive failure in mice.


Potential function of cholesterol in blood coagulation: amplification of phospholipid thromboplastic activity.


The isolation and specificity of alfalfa lipoxygenase.


Reactions of biological antioxidants. 3. Composition of biological membranes.


Sterol metabolism. XII. 26-Hydroxycholesterol in commercial cholesterol.


Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal reaction. Intoxicating blood levels of ethanol are maintained for several days in mice housed in an atmosphere of ethanol vapor. On removal from the alcohol, all the mice develop withdrawal signs. The signs can be graded to indicate the time course and intensity of the withdrawal reaction.


Monosodium glutamate effects.

Monosodium glutamate effects.


The comprehensive use of doppler ultra-sound in farm animal reproduction.


Boar semen sampling by electro-ejaculation.


Survival and fertilising capacity of boar semen following freezing by the pellet method.


A modified technique of parotid duct transposition for the treatment of keratoconjunctivitis sicca in the dog.


The haemagglutination inhibition test for pregnancy in the mare.


Ulceration of the ileum, and giardiasis in a Beagle.


The influence of sex and environmental factors on the behaviour of the white laboratory rat.


Selective hypogastric arteriography in uterine choriocarcinoma.


A study of the development in culture of x-irradiated mammalian cells and their descendants.


The effects of anticholinergics on the behavior of the rat in a solitary and in a social situation.


Chromosome aberrations and cell killing in plant and animal cells.


Operant therapy for an abnormal personality.


On the regulation of the synthesis of ribosomal proteins in L-cells.


Yeasts isolated from Long Island Sound.

Yeasts isolated from Long Island Sound.


Rabies. The epidemiology of a fickle virus.


Keeping Britain free of rabies.

Keeping Britain free of rabies.


Rabies vaccines--an assessment.

Rabies vaccines--an assessment.


Ad Hoc committee on drug abuse.

Ad Hoc committee on drug abuse.


A previously unrecognized southern species of Boletus.


Drug education training program.

Drug education training program.


"The starting place".

"The starting place".


A closer look.

A closer look.


Drugs vs. reality. The choice is ours.

Drugs vs. reality. The choice is ours.


From my side of the counter.

From my side of the counter.


The M.D. and the alcoholic.

The M.D. and the alcoholic.


Alcohol and other drug dependencies. Ten basic concepts.


A laboratory method to obtain fruit from cased grain spawn of the cultivated mushoom, Agaricus bisporus.


Histopathological studies on bone dysplasia of chickens. 3. A collective occurrence of bowleg (genu varum) among broiler chicks.


Studies on the etiology of infectious atrophic rhinitis of swine. 3. Field survey by agglutinatin test in rlation to incidence of B. bronchiseptica ad turbinate atrophy.


Pheochromocytoma masquerading as pre-eclamptic toxemia. Current concepts of diagnosis and treatment.


Ultrastructure of the deciduotrophoblastic interface of the mouse placenta.


The effect of estrogen on fetal oxygenation.


Kineticsspects of conformational changes in proteins. II. Structural changes in renaturation of denatured proteins.


Degradation of IgG3 monoclonal proteins during storage and in the presence of a thiol (DL-penicillamine).


Esterase and leucine aminopeptidase zymograms in the Indian meal moth Plodia interpunctella during development.


Proposed terminology for the anatomy of the rat stomach.


Endocarditis caused by Paecilomyces varioti affecting an aortic valve allograft.


Mercury in the environment: natural and human factors.


Mycotic infections on prosthetic and homograft heart valves: report of the first case of endocarditis caused by Hormodendrum dermatitidis.


The egg from a human case ochistosomiasis in aos.


Cranium of the late Palaeocene primate Plesiadapis tricuspidens.


Functional deficiency of autologous implants of the bursa of Fabricius in chickens.


[A new instrument for registering eye movement (X-Y tracker)].


Choriocarcinoma and adenocarcinoma of the esophagus with gonadotropin secretion.


Irrelevance of newborn waking states to some motor and appetitive responses.


Physical and chemical characterization of pig kidney particulate aminopeptidase.


Integrated static activity of the ampullae of Lorenzini after long-term exposure to various temperatures.


Electrical and mechanical events in depolarized cardiac muscle fibers during low sodium perfusion.


Carotid body oxygen consumption of the cat in vitro.


Influence of the mediastinum on the measurement of esophageal pressure and lung compliance in man.


An ultramicro method for the separate titration of hydrogen and ammonium ions.


Metabolic consequences of portacaval shunting in the rat. Effects on weight, food intake, intestinal absorption and hepatic morphology.


Angiosarcoma of the heart. First reported case in an adolescent.


Biochemical and serological characteristics of a Yersinia enterocolitica isolate.


A new theory of the innervation of bladder musculature. 3. Postganglionic synapses in uretero-vesico-urethral autonomic pathways.


The hydrogen peroxide fragility test and serum tocopherol level in anemias of various etiologies.


Urethral coitus--maximum urethral dilatation.


The treatment of urethral stricture: transurethral injection of triamcinolone: a preliminary report.


Tetrads with non-reciprocal segregation in Sphaerocarpos.


Somatic recombination in the common-AB diploid of Schizophyllum commune.


Breeding systems in fungi and their significance for genetic recombination.


Pot-smoking blood donors out.

Pot-smoking blood donors out.


Hazards of marihuana.

Hazards of marihuana.


Effect of iontophoretically applied biogenic amines and of cholinomimetic substances upon the activity of neurons in the superior colliculus and mesencephalic reticular formation of the cat.


Electrical and mechanical effects of procaine on mammalian heart muscle.


Two examples of severe fetal disease due to ABO incompatibility.


Chromatography of DNA on wool cortical cell protein.


Some aspects of fractionation of DNA on IR-120 A13+ columns. IV. Effect of protein association on the chromatographic profiles of DNA.


Noradrenaline metabolizing enzymes in normal and sympathetically denervated vas deferens.


Modification of Sindbis virus glycoprotein by host-specified glycosyl transferases. The amino acid sequence of the membrane glycoprotein of Sindbis virus is specified by the viral genome, but it has not been determined whether the carbohydrate portion of this molecule is specified by the cell or by the virus. We have examined two of the enzyme activities which catalyze transfer of monosaccharides to glycoprotein (sialyl and fucosyl transferases). Comparison of particulate enzyme preparations from infected and uninfected cells showed no difference in either the specific activity or acceptor specificity of these enzymes. This is impressive in view of the fact that the Sindbis membrane glycoprotein is the only glycoprotein synthesized in the infected cell. It was also determined that sialyl transferase from uninfected cells is capable of transferring ((3)H) sialic acid to acceptor prepared from Sindbis membrane glycoprotein. These results imply that at least some of the carbohydrate of the virus glycoprotein can arise by host modification.


Structural and nonstructural proteins of Saint Louis encephalitis virus. Analysis of purified Saint Louis encephalitis (SLE) virus by acrylamide gel electrophoresis revealed that the virions contained three structural proteins designated SP-1, SP-2, and SP-3 which had molecular weights of 63,000, 18,000, and 8,500, respectively. The envelope contained proteins SP-1 and SP-3 which were removed from the nucleocapsid by nonionic detergent treatment. Nucleocapsids prepared by deoxycholate treatment of complete virions had a density of 1.301 in potassium tartrate and contained SP-2 and SP-3. Brij-58-prepared SLE nucleocapsids had a density of 1.321 and contained only SP-2. Cycloheximide treatment for 1 hr in the presence of actinomycin irreversibly inhibited BHK cellular protein synthesis and reversibly inhibited the synthesis of SLE viral protein and ribonucleic acid. Three structural proteins and five virus-specific nonstructural proteins were detectable in SLE virus-infected BHK cells treated with actinomycin and pulse-inhibited with cycloheximide. Formation of each individual viral structural protein was detectable within 30 min after cycloheximide removal and continued with only minor changes from 12 to 18 hr after infection. Late in the infection cycle, synthesis of the nucleocapsid structural protein SP-2 and SP-3, the small envelope protein, was no longer detectable.


Polyacrylamide slab electrophoresis followed by electrophoresis into antibody-containing agarose gel.


A lithium buffer system for accelerated single-column amino acid analysis in physiological fluids.


Investigations on the reaction of azide with sperm whale ferrimyoglobin.


Pancreas acinar cell differentiation. IV. Assay of nanogram levels of chymotrypsin by radioactively labeled synthetic substrate.


Accidental organophosphate poisoning in cattle. Two case histories.


The effects of asphyxia on the mid-gestation human foetus.


Immunity to coccidiosis: protective effect of transferred serum in Eimeria maxima infections.


Seasonal change in a balanced polymorphism in Haemonchus contortus populations.


The structure and development of the macrogamete and oocyst of Eimeria acervulina.


Ascorbic acid and delta-5-3-beta-hydroxysteroid dehydrogenase in toad testis after carbon tetrachloride intoxication.


Thermal resistance of salmonellae in egg yolk containing 10 percent sugar or salt after storage at various temperatures.


Resistance potential of certain breeds of domestic fowl exposed to Raillietina tetragona infections. 3. Species of ants as intermediate hosts for certain fowl cestodes.


Abnormalities of the pelvic girdle and limbs of a broiler chick.


The gaseous environment of the chick embryo in relation to its development and hatchability. 5. Effect of carbon dioxide and oxygen levels during the terminal days of incubation.


Ornithine decarboxylase stimulation in rat ovary by luteinizing hormone. In normal albino rats with a 4-day estrous cycle, the activity of ovarian ornithine decarboxylase undergoes a transitory rise on the evening of proestrus and only at that time. The response could be elicited by the administration of either luteinizing hormone or human chorionic gonadotrophin. When antiserum to luteinizing hormone was injected at 2 p.m. on the day of proestrus, the induction of ornithine decarboxylase was blocked, an indication that the enzyme is under luteinizing hormone control. The strategic positioning of the induction of ornithine decarboxylase between the normal release of luteinizing hormone and ovulation impties that putrescine is associated with the ovulatory process, and opens a new avenue of research on the control of ovulation.