A new method for the separation of multicurie quantities of 90 Y from 90 Sr.


Studies on rehydrovitamin A 2.

Studies on rehydrovitamin A 2.


The influence of a vitamin A deficient diet upon sialic acid and hexosamine content of the submaxillary glands of rats.


Metabolic comparison between ubiquinone-7 and ubiquinone-9 in rats.


Metabolism and biological activity of retinoyl amide in rat.


High levels of vitamin B 12 versus minimum requirement: biological and behavioral differences.


The effect of vitamin C depletion on the free amino acid content in blood plasma of the guinea pig.


Hemoglobin: a simple "backbone" type of molecular model.


An improved method for the measurement of leucocyte ascorbic acid concentrations. An improved method for measuring leucocyte ascorbic acid concentrations which employs sodium metrizoate instead of dextraven for separation of red blood cells out of the supernatant fluid is described.  Results of duplicate analyses by the dextraven and metrizoic methods are described in school children, students, adults, and geriatric subjects, and it is shown that consistent results are obtained by both methods.  Parallel analyses were performed onthe same samples of blood by the two methods.  The metrizoic method gave values for leucocyte ascorbic acid concentrations 1.6 times as high as those obtained by the dextraven method.  The time required for separation of the red cells was 3 times as long and contamination of the supernatant fluid with red blood cells was much greater in the dextraven method.  The longer period required for separation of red cells in the dextraven method allowed a greater release of ascorbic acid from the leucocytes into the supernatant fluid than in the metrizoic method.  This accounts for the higher leucocyte ascorbic acid concentrations found in the metrizoic method.


Osteoid tissue in normal and osteoporotic individuals.


The apparent free testosterone concentration, an index of androgenicity.


Measurement of pregnenolone sulfate after solvolysis in human pregnancy plasma.


Probable sleep dependency of diurnal rhythm of plasma growth hormone response to hypoglycemia.


Endocrine function and glucose metabolism in patients with Parkinson's disease and their alternation by L-Dopa.


Thyroidal 131-I turnover in hypothyroidism: aberrant result in primary hypothyroidism.


Carbohydrate metabolism in pregnancy. IX. Plasma levels of gluconeogenic fuels during fasting in the rat.


On the mechanism of inhibition in fluid reabsorption by the renal proximal tubule of the volume-expanded rat. We undertook to determine the extent to which the inhibition in absolute proximal fluid reabsorption in response to expansion of extracellular volume with noncolloid-containing solutions is the result of concomitant reductions in postglomerular (efferent arteriolar) protein concentration. Selective elevation of efferent arteriolar oncotic pressure in volume-expanded rats (Ringer's 10% body weight) to levels slightly in excess of normal by microperfusion with 9-10% albumin-Ringer's solution nearly completely reversed the inhibition in absolute and fractional reabsorption in adjacent proximal tubules. In contrast, during similar microperfusion with a 6-7% albumin solution, no increase in proximal reabsorption was measured. We interpret these findings to indicate that the bulk of the inhibition in absolute proximal reabsorption in response to volume expansion with colloid-free solutions is causally mediated by the accompanying parallel decline in postglomerular vascular protein concentration.


Disulphates of neutral steroids in the amniotic fluid from anencephalic preganancies.


Genetic variation in the neurohypophysial hormones of the mouse, Mus musculus.


Preparation and properties of subunits of human luteinizing hormone.


Immunoassay of human luteinizing hormone using univalent radioactive antibodies.


The effects of neurohypophysectomy on the pattern of renal excretion in the duck (Anas platyrhynchos).


Chemistry of cephalosporin antibiotics. 24. 2-thiomethyl- and 2-thiomethylenecephalosporins.


Abnormal bone marrow morphology in the premature infant associated with maternal alcohol infusion.


Pituitary-gonadal function in pubertal gynecomastia.


Intestinal absorption of insulin in patients with fibrocystic disease.


An air curtain incubator for use in an intensive-care nursery.


A practical stethoscope for use in the neonate.


Imperforate anus (polydactyly) vertebral anomalies syndrome: a hereditary trait?


Effect of mineralocorticoids on sweat sodium in cystic fibrosis.


Turner's syndrome with XO-XX mosaicism and normal puberty.


Somatic cell hybrids: applications relevant to genetic disease.


Thermodynamics of aqueous solutions of tetrabutylammonium carboxylates. Model systems for the hydrophobic interaction in proteins.


Autosomal dominant inheritance in Albright's hereditary osteodystrophy.


Exchange transfusion in the newborn infant with fresh and "old" blood: the role of storage on 2,3-diphosphoglycerate, hemoglobin-oxygen affinity, and oxygen release.


Symptom expression in Christian and Buddhist hospitalized psychiatric patients of Japanese descent in Hawaii.


Deference and ethnic differences in voice levels.


Dogmatism and social distance: a cross-cultural study.


Induced self-esteem as a determinant of behavior.


The attribution by opiate addicts of characteristics of addict subgroups and to self.


Performance time as a function of sex, locus of control, and task requirements.


Temperatures and their accuracy.

Temperatures and their accuracy.


Fat embolism.

Fat embolism.


Adrenocortical steroids.

Adrenocortical steroids.


Total laryngectomy.

Total laryngectomy.


Someone is asking us. 2.

Someone is asking us. 2.


New hospital--new patterns of care.

New hospital--new patterns of care.


In Vietnam--the SCF in action.

In Vietnam--the SCF in action.


The strong and the weak.

The strong and the weak.


Lysistrata looks at community health teams.


Change in subnormality care.

Change in subnormality care.


Introital stenosis and z-plasty.

Introital stenosis and z-plasty.


Diagnosis and prognosis of cervical dysplasia.


Ectopic mucinous cystadenoma. A case report.


Ultrastructure of cultivated amniotic fluid cells.


Disseminated intravascular coagulation complicating hysterotomy in elderly gravidas.


Cushing's syndrome complicating pregnancy. A case report. A case of a rare association between pregnancy and the development of Cushing's syndrome is discussed.  A 29-year-old woman developed Cushing's syndrome, characterized by hypokalemia, a high level of urinary 17-hydroxycorticoids not suppressed by dexamethasone therapy, a high level of plasma 11-hydroxycorticoids which did not show diurnal  variation and failed to show suppression after dexamethasone therapy, and a high level of urinary 17-ketosteroids, within 12 weeks of her first pregnancy.  Clinical and biochemical abnormalities disappeared rapidly after dilatation and curettage.  No evidence of an ectopic ACTH-producing tumor or an adrenal cortical tumor was found.  Abnormalities did not reappear with administration of HCG or with sequential estrogen-progestogen treatment.


Diurnal cycle of adrenal activity in secondary amenorrhea.


Serum gonadotropin levels and ancillary studies in Stein-Leventhal syndrome treated with clomiphene citrate.


Control of ovulation time with low-dose estrogens.


Physiologic and endocrinologic study of the anencephalic syndrome.


Cytogenetic studies of conjoined twins. A case report.


Monosomy E mosaicism in a stillborn infant. A case report.


Divergent and crossed obstetric forceps. Comparative study of compression and traction forces.


Vaginal tubal ligation at time of vacuum curettage for abortion.


Coexistent trophoblastic tumor and viable pregnancy.


Ectopic pregnancy concomitant with twin intrauterine pregnancy. A case report.


Obstetric analgesia. Pentazocine and meperidine in normal primiparous labor.


Orgasm during late pregnancy. Possible deleterious effects.


The PMPO syndrome (postmenopausal palpable ovary syndrome).


Montgomery's tubercles. Sebaceous glands.


A combined tenaculum and speculum.

A combined tenaculum and speculum.


Abortion mortality statistics.

Abortion mortality statistics.


Carcinoma of the cervix in young women. I. Invasive carcinoma.


Nontraumatic fetal EKG electrode.

Nontraumatic fetal EKG electrode.


The effects of hippocampectomy on alternation behavior and response of novelty.


Dietary self-selection at cold temperatures.


Ventricular modification of drinking and eating behavior.


Further study of the learning deficit produced by hydroxylamine.


Effects of telencephalic and olfactory lesions on appetitive learning in goldfish.


Classical conditioning with brain stimulation at one site serving as both CS and US.


The role of olfactory and orosensory factors in the alcohol preference of inbred strains of mice.


Absence of effect of injections of the intestinal hormones secretin and choecystokinin-pancreozymin upon feeding behavior.


Eating patterns and body weight change of snakes when eating and when food deprived.


Glucose preference in the guinea pig.

Glucose preference in the guinea pig.


Method for recording foot pad impedance in freely moving mice.


Learning of food and water positions by hippocampus damaged rats.


Actinomycin D injected into the hippocampus of chicks: effects upon imprinting.


Evoked responses and background unit activity during appetitive conditioning in dogs.


Motivated feeding behavior elicited by electrical stimulation of the septum.


Light-dark rhythms in rat eating and drinking behavior.


Evoked responses in brain motor areas during the immobility reflex ("animal hypnosis").


Characteristics of sleep following sexual activity and wheel running in male rats.


Midbrain reticular formation lesions: habituation to stimulation and copulatory behavior in male rats.


A study of the relationship between the visual system and the effects of d-amphetamine.


Factors affecting performance on a shock escape task in rats with septal lesions.


Effects upon conditioned response time of contingent photic stimulation in cats.


Antidotal thirst and lithium excretion in rats with hypothalamic lesions.


Dopa reversal of reserpine enhancement of audiogenic seizure susceptibility in mice.


Interactions of scopolamine and physostigmine with ECS and one trial learning.


Contour discrimination in the rat following removal of posterior neocortex.


The sexual behavior of male rats after bilateral section of the hypogastric nerve and removal of the accessory genital glands.


Plasma corticosterone increases produced by extinction of operant behavior in rats.


A device for the chronic intra-ventricular infusion in freely moving rats.


A biphasic radio-controlled stimulator.

A biphasic radio-controlled stimulator.


Biosynthesis of diosgenin in germinating seeds of Balanites Aegyptiaca.


Studies on the induced mutations in medicinal plants. I. Spectrum of adult plant mutations in Atropa belladonna.


Electron microscopical studies of rose petal cells during flower maturation.


The effect of ricin on the germinative capacity of different seeds.


Comparative performance of diploid and tetraploid Mentha arvensis and evaluation of their oils.


Essential leaf oils in Calycanthus Floridus.


Chemistry of ursolic acid.

Chemistry of ursolic acid.


Contribution to the study of storage of Digitalis lanata leaves.


On the intrinsic factors and nodal complexities of Dioscorea deltoidea and Dioscorea prazerii.


Isolation of two new flavonoids from the root of Glycyrrhiza glabra var. typica.


The study of shea butter. 1. Physico-chemical properties.


[Insuline and the transport across the cell membranes].


Erythropoietic effects of 5-hydroxytryptamine.


Inhibition of ocular herpes simples infection in rabbits by extracts of Burkitt's lymphoma cell cultures.


Effect of x-irradiation on protein synthesis in pig thyroid microsomal suspensions.


Macrophage pinocytosis: the removal and resynthesis of a cell surface factor.


The relationship between postexercise concentration of serum pyruvate and physical fitness.


Treatment of nitrite-induced methemoglobinemia with hyperbaric oxygen.


Prolongation of RBC survival in the hypophysectomized rat.


Fetal and placental composition in experimental maternal diabetes.


Effects of gonadectomy on the uptake of polycyclic hydrocarbons by rat liver nuclei, DNA, and histones.


Serum follicle-stimulating hormone (FSH) in normal and androgenized male and female rats.


Depressor and pressor afferent fibers in the carotid sinus nerve of the dog.


Effect of the exogenous amino acids concentration on the rate of gluconeogenesis in liver slices.


Ethanol-induced fatty liver in rats: effects of pyrazole and glucose.


Development of abnormal lipid bodies in various sphingolipidoses.


Renal responses to actinomycin D and aldosterone in the hypophysectomized rat.


A technic for repeated bile collections from an intact enterohepatic circulation.


Lymphocyte transformation and hepatitis. II. Lack of direct in vitro inhibition by purified Australia antigen.


Pulmonary hypertension and acidemia: activation of pressor substances from whole blood fractions.


The variation of glucose metabolism in human erythrocytes in the presence of L-thyroxine.


Aggregation of red cells and effects of nonsteroidal anti-inflammatory drugs.


Antiarthritic effects of the antispermatogenic agent 2,3-dihydro-(1-naphthyl)-4-(1H)-quinazolinone (U-29,409).


On carcinoma growth and vascular supply: a study of mouse mammary tumor strain MTG-B.


Studies concerning the pathogenesis of neurogenic hypercholesterolemia. I. Independence of hypercholesterolemia and biliary excretion.


Increased turnover of intestinal mucosal cells of germfree mice induced by cholic acid.


Do precapillary sphincters respond to vasoactive substances in an all-or-none manner?


Fibrinogenolysis and fibrinolysis with tissue plasminogen activator, urokinase, streptokinase-activated human globulin, and plasmin.


Production and excretion of bilirubin in Gunn rats treated with phenobarbital.


Platelet aggregation produced by collagenolysis product peptides.


ATP activation of the neutral proteolytic activity. A widespread phenomenon.


Phospholipase C effect on water, sodium, potassium content and amino acid transport of kidney cortex slices.


The selective membrane filtration of an ESF-generating factor (EGF) in the presence of erythropoietin (ESF).


The hypertrophic scar. Glycoprotein and collagen components of burn scars.


Direct measurement of leukocyte motility: effects of pH and temperature.


The effect of nicotine on regional blood flow in the the canine heart.


Serotonin, pulmonary hypertension, and airway constriction in the anesthetized dog.


Inhibition of urea biosynthesis and conversion of L-citrulline-6- 14 C to  14 C-urea by  -methyl aspartic acid and  -methyl aspartic acid.


Prostaglandin F 1a  induced stimulation of rabbit testicular contractions.


Zinc sulfate-failure as an accelerator of collagen biosynthesis and fibroblast proliferation.


Effect of exercise and dietary carbohydrate on glucose oxidation in rats.


The specificity of the regulation of organ growth: the effect of tissue extracts on the incorporation of tritiated thymidine in liver and kidney.


Antibody response in humans to neuraminidase of A2-Aichi-68 and B-Mass-66 influenza viruses.


Inactivated complement fixing antigen from Venezuelan equine encephalitis virus grown in tissue culture.


The influence of dietary sodium chloride on in vitro renin release from rat kidney slices.


Sperm capacitation assay in superovulated rabbits with uterine or oviducal inseminations.


D-galactosamine hepatotoxicity. II. Mechanism of fatty liver production.


Antiserum inhibition of rabbit spermatozoal adherence to ova. The in vitro effects of different normal and immune sera, rabbit oviductal fluid, and culture media from incubations of female reproductive tissues on the adherence of rabbit spermatozoa to rabbit and rat ova is described.  There were no apparent differences in results due to species of ova.  Adherence of spermatozoa to ova was not affected by treatment with normal sera.  Antisera against materials that contained spermatozoa such as semen epididymal spermatozoa and testis completely inhibited the spermatozoa from attaching to ova and caused considerable agglutination of sperm cells in the incubation slides.  When the agglutinating and immobilizing activities of rabbit and goat antisera were removed by papain treatment the antiadherent effect of the antisera was unaffected.  Oviductal secretions and concentrated media from the culture of reproductive tissue from female rabbits isoimmunized with semen inhibited adherence of sperm.


Migration in aphids.

Migration in aphids.


Gamma densigraphy in the evaluation of regional pulmonary ventilation.


The brown recluse spider bite: controlled evaluation of treatment using the white rabbit as an animal model.


Socio-sexual problems in mentally handicapped females.


Metabolism of fibrinogen in cirrhosis of the liver.


Is Head Start dying?

Is Head Start dying?


Some characteristics of mental defectives displaying self-mutilative behaviors.


Do cost variations reflect need variations--in the education and training of the institutionalized retardate?


Chromosomal breakage in diffuse scleroderma. A study of 27 patients.


The effect of institutionalization on educable mental retardates' expectancy of failure.


Evaluation of a remotivation program with institutionalized mentally retarded youngsters.


Parent-school collaboration via educational merit badges?


The structure and assembly of murine leukemia virus: intracellular viral RNA.


Partial degradation of tobacco ringspot virus in a single-phase phenol system: formation of new products.


Factors affecting the proportion of nucleoprotein components of tobacco streak virus.


An in vitro protein synthesizing system from mouse L fibroblasts infected with reovirus.


The effect of tetrachloro-o-benzoquinone on southern bean mosaic virus and on its nucleic acid.


Examination of alfalfa mosaic virus protein on polyacrylamide gels.


Sedimentation equilibrium analysis of the molecular weight of a tumor virus RNA.


RNA-dependent RNA polymerase activity of the influenza virus.


Extraction and assay of TMV RNA.

Extraction and assay of TMV RNA.


Relation between virus-induced RNA polymerase activity and the synthesis of broadbean mottle virus in broadbean.


Factors affecting the amount of oligonucleotides in reovirus particles.


Temperature-sensitive mutants of human adenovirus type 12.


The epidemiology of active tuberculosis in hospital employees in Ontario, 1966-1969.


Reactivation of inactive tuberculosis in Northern Canada.


The bronchial epithelium in chronic bronchitis. I. Exfoliative cytology during stable, acute bacterial infection and recovery phases.


Correlation of magnifying pulmonary wedge angiogram and pulmonary hemodynamics.


Exercise-induced asthma.

Exercise-induced asthma.


Further evidence against the concept of decreased phage neutralizing ability of serum of patients with sarcoidosis.


Pneumothorax and bilateral honeycombed lung in Marfan syndrome. Report of a case and review of the pulmonary abnormalities in this disorder.


Smoking and personality.

Smoking and personality.


Smoking withdrawal and changes of cardiorespiratory fitness.


Death certificates and tuberculosis register cards. A correlation study of 108 cases.


Studies on the transient lung shadow detected by radiographic examination.


A survey of a representative sample of physicians in New Jersey concerning their use of chemoprophylaxis for the prevention and treatment of tuberculosis.


Use of tape recordings of respiratory sound and breathing pattern for instruction in pulmonary auscultation.


Investigation by seroagglutination of strains of the Mycobacterium intracellulare-M. scrofulaceum group from house dusts and sputum in Southeastern Queensland.


The role of oxygen therapy in the rehabilitation of patients with chronic obstructive lung disease.


Ethambutol versus streptomycin.

Ethambutol versus streptomycin.


Application of the Doppler ultrasonic flowmeter in the surgical treatment of arteriovenous fistula.


Idiopathic unilateral hyperlucent lung.

Idiopathic unilateral hyperlucent lung.


Experiences with the Moretz clip: 100 cases.


A new clinical entity: human infection with Yersinia presenting as an acute abdomen.


Secondary carcinoma in the penis. Report of three cases and literature review.


Intestinal malrotation with midgut volvulus occurring with aganglionosis of colon and terminal ileum in a newborn infant.


Gastric surgery for duodenal ulcer: Billroth II procedure and vagotomy in 104 patients.


Management of antepartum thrombophlebitis.


Pseudocyst of the spleen.

Pseudocyst of the spleen.


Effects of deoxyglucose on platelet metabolism.


Formation of glucosamine 6-phosphate in regenerating rat liver.


The toxicity of monosodium glutamate in young rats.


Urinary excretion of tertiary amino methoxy methylenedioxy propiophenones as metabolites of myristicin in the rat and guinea pig.


Stimulation of mitochondrial protein synthesis and oxygen consumption by thyroxine in vitro without deiodination to triiodothyronine.


Studies on cytosol aldosterone binding macromolecules.


Regulation of functionally related enzymes during alternative developmental programs.


Regulation of glucose 6-phosphate dehydrogenase formation in mammary organ culture.


Evidence for the aggregation of hyaluronateprotein fractionated by chromatography on agarose.


Proximal to distal variations in enzymes of the rat intestine.


Gas chromatographic determination of phenylalanine ammonia-lyase activity in two varieties of Nicotiana tabacum.


The origin of serum amylase. Electrophoretic studies of isoamylases of the serum, liver and other tissues of adult and infant rats.


Blood clam (Anadara inflata) red cells. Partition in aqueous two-polymer phase systems.


Blood clam (Anadara inflata) hemoglobins. Partition in aqueous two-polymer phase systems and alkali denaturation.


Vibrio mutants of Rhodospirillum rubrum.


The mode of action of warfarin. An intracellular precursor for factor VII in rat liver.


Further studies on nuclear ribonucleoprotein particles containing DNA-like RNA from rat liver.


Raman studies of nucleic acids. IV. Vibrational specra and associative interactions of aqueous inosine derivatives.


An agar-diffusion method for quantitative determination of ribonuclease.


Translational control of protein synthesis: a simulation study.


Inhibition of glycoprotein synthesis by cycloheximide in liver and Ehrlich tumor cells.


Thymidine labeling of pyrimidine isostichs from human lymphocyte DNA during repair after damage with N-acetoxy acetylaminofluorene or nitrogen mustard.


Uptake of polynucleotides by intact mammalian cells. XII. Stimulation of the uptake of ribopolynucleotides by deoxyribonuclease.


Serum complement (C'3) and immunoglobulin levels in dermatitis herpetiformis.


The incidence and other aspects of factitious wealing (dermographism).


Dyskeratosis in Bowen's disease: the ultrastructure and fate of keratinocytes with altered tonofilament-desmosome complexes.


Effects of propranolol on the response of human eccrine sweat glands to acetylcholine.


Mycosis fungoides: its management with superficial X-rays and strontium 90 therapy compared.


The evaluation of several topical corticosteroid preparations in the blanching test.


Mechanism of action of accelerants. The effect of cutaneously-applied penetration accelerants on the skin circulation of the rat.


Profuse mollusca contagiosa of the face induced by corticosteroids.


Placebo ointment response in the blanching test.


Contact dermatitis. XVI. Patch testing?

Contact dermatitis. XVI. Patch testing?


A suggestion for the nomenclature of the fluorescent banding patterns in human metaphase chromosomes.


Ocular albinism in Newfoundland.

Ocular albinism in Newfoundland.


Fresnel prism membrane in the treatment of strabismus.


Anterior central opacities of the capsule in senile lens exfoliation.


The surgery of congenital nystagmus.

The surgery of congenital nystagmus.


Glaucomato-cyclitic crisis, gonioscopic findings.


A modification of the Armaly visual field screening technique for glaucoma.


Primary orbital perioptic meningioma: a case report.


The prevention of vitreous loss in cataract surgery.


Scanning electron microscopy of the tunica vasculosa lentis of the rat.


Studies of spatial summation of central retinal areas in normal people of all ages.


Soft hydrophilic contact lenses.

Soft hydrophilic contact lenses.


Primary squamous cell carcinoma and adenocanthoma of the colon.


Analysis of the cell kinetics of human solid tumors.


Immunogenic efficacy of various  syngeneic tumor cell preparations.


Cell-mediated immune reaction to two gynecologic malignant tumors.


College of Cancer.

College of Cancer.


Intrahepatic arterial infusion with 5-fluorouracil.


Chemotherapy for metastatic colorectal liver carcinoma by intra-aortic infusion.


Diagnosis and management of renal cell carcinoma. A clinical and pathologic study of 309 cases.


A review of the treatment of cancer of the mobile portion of the tongue.


Combination of cyclophosphamide and estrogen therapy in DMBA-induced rat mammary cancer.


Cryonecrosis of normal and tumor-bearing rat liver potentiated by inflow occlusion.


RNA-mediated transfer of tumor immunity--a new model for the immunotherapy of cancer.


Cancer of the lung. An in-depth analysis of prognostic factors.


Familial medullary thyroid carcinoma, pheochromocytoma, and parathyroid adenoma (Sipple's syndrome). Study of a kindred.


Prognostic significance of histologic host response in cancer of the larynx or hypopharynx.


Some aspects of the immune defense against cancer. I. In vitro studies on animal tumors.


Some aspects of the immune defense against cancer. II. In vitro studies on human tumors.


Radical hysterectomy and pelvic lymphadenectomy for carcinoma of the uterine cervix.


Irradiation of  in-situ' and invasive squamous cell carcinomas of the vagina.


Renal toxicity in man treated with mitomycin C.


Vascular invasion in Hodgkin's disease: its relationship to involvement of the spleen and other extranodal sites.


Problems of interpretation of liver biopsy in Hodgkin's disease.


Prophylactic internal fixation of the femur in metastatic breast cancer.


Lower esophageal sphincter dysfunction in achalasia.


An epidemiological study of Crohn's disease in Northeast Scotland.


A controlled clinical trial of cholestyramine in the treatment of gastric ulcer.


Pancreatitis as a complication of regional enteritis of the duodenum.


Emptying and absorption of caffeine from the human stomach.


Gastrin inhibition of intestinal absorption in dogs.


Unstirred water layers and absorption across the intestinal mucosa.


Extensive stenosis of the colon and fistula formation following amoebic dysentery.


Cerebral edema: a major complication of massive hepatic necrosis.


Myocardial infarction in the elderly surgical patient.


L-dopa: its effect on the cardiovascular system.


Changes in the nervous system during cerebral atherosclerosis and aging.


When a negative x-ray gives no positive answer.


The effect of cardiogenic shock on the superior mesenteric circulation.


New concepts in temporary circulatory assist for treatment of cardiogenic shock.


Effects of breed, sire, sex and age on degree of molar development in yearling beef cattle.


The density of bones in the young skeleton.


Human head circumference from birth to early adulthood: racial, regional, and sex comparisons.


The body weight-organ weight relationships of the immature hamster, Mesocricetus auratus, from birth to weaning.


Age-weight relationships of selected organs and body weight for miniature swine.


[Surgical management of pituitary tumors].


[Photocoagulation of diabetic retinopathy].


[The halo appliance for traction and immobilization of the cervical spine].


[Neuroleptanalgesia in cesarean section].


[Mortality in bronchial asthma and its causes].


Effects of the electrical stimulation of the crossed olivocochlear bundle on cochlear potentials recorded with intracochlear electrodes in guinea pigs.


Reversals in the perception of noise and tone patterns.


Detection and duration discrimination of noise increments.


Contrast in detection with gated noise.

Contrast in detection with gated noise.


Monaural detection with contralateral cue (MDCC). 3. Sinusoidal signals at a constant performance level.


Most comfortable loudness for pure tones, noise, and speech.


Detection of a narrow-band noise as a function of the interaural correlation of both signal and masker.


Spatial patterns of cochlear difference tones.


Acoustic level and vocal effort as cues for the loudness of speech.


Voice spectrograms as a function of age, voice disguise, and voice imitation.


A masking noise with speech-envelope characteristics for studying intelligibility.


Ultrasonic scans of the dorsal surface of the tongue.


Perceptual structure of 12 American English vowels.


Determination of vocal-tract shape from impulse response at the lips.


The laterality effect in lingual-auditory tracking.


Discrimination of filtered-clipped speech by hearing-impaired subjects.


Behavioral measurements of absolute and frequency-difference thresholds in guinea pig.


a study of the influence of the olivocochlear bundle on the N1 responses to repeated tone pulses.


Effects of interstimulus interval on the listener's ability to perceive an intensity-produced lateral shift.


Auditory threshold at 125 Hz as a function of signal duration and signal filtering.


Correspondence between cochlear microphonic sensitivity and behavioral threshold in the cat.


The auditory threshold for short-duration pulses.


Some suggestions concerning basilar-membrane displacement and signal audibility.


Effects of auditory masking on vocal intensity and intraoral air pressure during sentence production.


Regulation of vocal intensity during vocal fry phonation.


Ultrasonic examination of protein-transfer reactions at the alpha-amino and side-chain groups of arginine and lysine in aqueous solution.


Community hospital problem-oriented medical care service.


On the metabolism of prostaglandin F-2-alpha in female subjects.


Oral cholecystography and intravenous cholangiography.


Extracorporeal circulation. II.

Extracorporeal circulation. II.


Maine's Sentinel Physician System.

Maine's Sentinel Physician System.


Cervical cord tumor in two haemophilic brothers.


Delayed radiation myelopathy in man. Report of twelve necropsy cases.


Effect of vitamin B 6  on levodopa-induced changes in spinal fluid homovanillic acid.


Hyperbilirubinaemia in acute ischaemic stroke.


Monoamines in the human neostriatum: topographic distribution in normals and in Parkinson's disease and their role in akinesia, rigidity, chorea, and tremor.


Leucocyte metabolism in hereditary neuromuscular disorders.


Aldolase isoenzymes in serum and muscle from patients with progressive muscular dystrophy and from human foetus.


Placental transfer of 2,3,5-triiodobenzoic acid in the rat.


Stereochemical investigations of local anesthetic action.


Pharmacokinetics of phosphonomycin in Man. I. Intravenous administration.


In vivo and in vitro availability of commercial warfarin tablets.


Kinetics of flocculation and-or coalescence of dilute oil-in-water emulsions.


Crystal structure of a 1:1 aminopyrine-barbital complex.


Interaction of bishydroxycoumarin with polyvinylpyrrolidone.


Synthesis and selected pharmacology of anthranilamides.


Pharmacokinetics of ampicillin trihydrate, sodium ampicillin, and sodium dicloxacillin following intramuscular injection.


Nature of bonding in montmorillonite adsorbates. I. Surface adsorption.


Biological disposition of pentylenetetrazol-10- 14 C in rats and humans.


Fluorometric analysis of ampicillin in biological fluids.


Linear free energy models for ester solvolysis with a critical examination of the alcohol and phenol dissociation model.


Combined GC and high resolution mass spectrometric determination of probenecid.


Automated IR technique for determination of methylphenidate hydrochloride in tablet formulation.


Effect of concentration and size of lubricant on flow rate of granules.


Determination of chloride in aluminum hydroxide gels by use of a chloride-selective electrode.


Impact test for hardness of compressed powder compacts.


Instrumented pilot plant lyophilizer: its versatility in developing and programming production cycles.


Effect of viscosity on thiamine and riboflavin absorption in man.


Spectrophotometric determination of anthramycin.


Degradation products of chloramphenicol.


Natural coumarins. XII. Umbelliprenin, a constituent of ammi majus L. fruits.


Effects of aspirin on gastric mucosae of albino rat and Mongloian gerbil (Meriones unguiculatus).


Isolation and identification of 8-(2-diphenylmethoxy-N-methylethylamine)-1,3-dimethylxanthine from dimenhydrinate.


Stability of morphine in aqueous solution. IV. Isolation of morphine and sodium bisulfite interaction product.


Effect of dissolution media on disintegration and dissolution of hydrochlorothiazide tablets.


Controlled potential coulometric analysis of amine-oxides of pharmaceutical interest.


Chemistry and pharmacological evaluation of 1-phenyl-2-propanols and 1-phenyl-2-propanones.


NMR studies on enolization of 1-p-chlorophenyl-1-hydroxy-2-propanone.


New compounds: 2,4-dinitrobenzenesulfenamides.


Translocation of ligand conformational free energy in receptor activation: a possible functional role of conformational isomerism in drug action.


Environmental effects on the deprotonation of indole derivatives in alkaline ices.


The effect of varied excitation on the fluorescence spectra of 2-phenylnaphthalene and biphenyl: photoselection of conformers.


Relevance of vascular disorders to audiological findings.


Reflections on conceptualizing the stuttering therapy process from a single theoretical framework.


Observations on relations between thresholds for pure tones and for speech.


A preliminary report of some atypical movement patterns in the tongue, palate, hypopharynx, and larynx of patients with spasmodic dysphonia.


A technique for teaching the laryngectomized to trap air for the production of esophageal speech.


Token loss in speech imitation training.


Therapy for reduction of continuous phonation in the hard-of-hearing population.


Parent education in a public school program of speech therapy.


Bekesy audiometry in simulated hearing loss.


Informational specificity: a correlate of verbal output in the diagnostic interview.


The expanding responsibilities of the speech and hearing clinician in the public schools.


Lip taping for buccal-labial insufficiency.


Management of a patient with velopharyngeal incompetency of undetermined origin: a clinical report.


Parent-clinicians in the language training of an autistic child.


Intracarotid sodium amytal testing on normal, chronic adult stutterers.


Gadgetry to heighten sensation of nasality.


More on bottle-feeding.

More on bottle-feeding.


Reaction to age as a factor in chronic aphasia in stroke patients.


Septate and gap junctions between the epithelial cells of an invertebrate, the mollusc Cominella maculosa.


Intercisternal parallel filaments in the endoplasmic reticulum in cells of the rat subcommissural organ.


Ultrastructural studies on the synaptology of the inferior mesenteric ganglion of the cat. II. Specialized serial neuronal contacts between preganglionic end fibers.


Ultrastructural studies on the synaptology of the inferior mesenteric ganglion of the cat. 3. The structure and distribution of the axodendritic and dendrodendritic contacts.


Management of cardiac problems in the intensive care unit.


Use of Probenecid in antimicrobial therapy.


Model experiments on the molecular mechanism of action of 6-hydroxydopamine.


The influence of tetraethylammonium ion on the reaction between acetylcholinesterase and selected inhibitors.


An infrared study of the interaction of caffeine and theophylline with 9-ethyladenine in chloroform solution.


The binding of 3-methylcholanthrene to macromolecular components of rat liver preparations.


Interaction of several coumarin compounds with human and canine plasma albumin.


Effect of administration of 3-methylcholanthrene on the salt-extractable chromatin proteins of rat liver.


The labeling in vivo of monoamine oxidase by  14 C-pargyline: a tool for studying the synthesis of the enzyme.


Biochemical studies on a variant of branched chain ketoaciduria in a 19-year-old female.


Thymidine kinase and thymidylate synthetase in meristems of roots of Viciafaba.


Fine structure of resting and germinating Penicillium chrysogenum conidiospores.


Effects of high altitude exposure on the lungs of young rats.


Multigrade loading test in the diagnosis of ischaemic heart disease.


Effect of temperature of inspired air on the metabolic response of the newborn.


Regulation of temperature in pathological neonates.


Influence of noise on the electrical activity of human brain.


Psychologic correlates of serum cholesterol in man. A longitudinal study.


Nuclear medicine in Czechoslovakia.

Nuclear medicine in Czechoslovakia.


Denaturation of human serum albumin followed by polarography, electrophoresis, ultracentrifugation and immunoelectrophoresis.


Maternal deprivation and the response to Ehrlich carcinoma in BALB-c mice.


Individual differences in autonomic responsivity in the adult rat. Neonatal influences.


Denial among male heart patients. An empirical study.


Perinatal conditions and infant development in children with schizophrenic parents.


Schizophrenia--onset in infancy?

Schizophrenia--onset in infancy?


Mental disability as a basis for contraception and sterilization.


Family planning and the law.

Family planning and the law.


Maternal effects in genetic diseases.

Maternal effects in genetic diseases.


A foundation for informed eugenics.

A foundation for informed eugenics.


Fertility of narcotics addicts and effects of addiction on the offspring.


Addiction, fertility, and pregnancy.

Addiction, fertility, and pregnancy.


Mental retardation and fertility.

Mental retardation and fertility.


Differential fertility and intelligence: current status of the problem.


Marriage and fertility of psychiatric patients compared with national data.


Marital status of first admissions to psychiatric beds in England and Wales in 1965 and 1966.


Mental illness and reproduction.

Mental illness and reproduction.


Overripeness of the egg as a possible cause in mental and physical disorders.


The effect of expecting to be evaluated on change toward favorable and unfavorable information about oneself.


Does the trigger pull the finger? An experimental test of weapons as aggression--eliciting stimuli.


Parental behavior and dimensions of adolescent self-evaluation.


Studies on the accumulation mechanisms of radioisotopes used in tumor diagnostic.


Pharmaceutical studies on a  99m Tc-coated carbon suspension intended for diagnostic pulmonary scanning.


Alterations of thyroid morphology in mice by radioactive phosphorus--late effects.


The effect of colloidal iron hydroxide on radiocerium metabolism in rats and mice.


Postural dependent activity changes of urinary LDH as a diagnostic aid in nephroptosis.


The significance of electron microscopy in urological kidney diseases.


The role of roentgenographic procedures in staging of carcinoma of the urinary bladder by TNM system.


Clinical application of fiber-optic pyeloureteroscope.


The relationship between social behavior and the use of space in the benthic fish Chasmodes bosquianus Lacépéde (Teleostei, Blenniidae) I. Ethogram.


The reproductive behaviour of the pomacentrid fish, Chromis caeruleus.


The fine structure of the Necturus (amphibia) heart.


Influence of some endocrine glands, hormones and blinding on the histology and porphyrins of the Harderian glands of golden hamsters.


The brain venous system of the dog.

The brain venous system of the dog.


The histochemical and microscopical differentiation of the respiratory glands around the maxillary sinus of the rat.


Bacteriologic survey of lyophilized chemical quality control materials.


Detection of clot retraction through changes of the electrical impedance of blood during coagulation.


Zonal and immunoelectrophoretic patterns of normal and nephrotic renal extracts: a preliminary study.


Infectious mononucleosis simulating Hodgkin's disease: a patient with Reed-Sternbery cells.


Mucoepidermoid carcinoma of the liver.

Mucoepidermoid carcinoma of the liver.


"Benign" rectal carcinoids: a report of two patients with metastases to regional lymph nodes.


Melanosis of the prostate gland.

Melanosis of the prostate gland.


Variations in cellulose acetate membranes for lipoprotein electrophoresis.


Customized photomicrography.

Customized photomicrography.


The use of SI in reporting results in pathology.


Adsorption of guanine and guanosine at the pyrolytic graphite electrode. Implications for the determination of guanine in the presence of guanosine.


An improved method for the determination of cobalt in biological materials.


Use of an analog on-line computer for the evaluation of pulmonary resistance and dynamic compliance in the anesthetized dog.


Action of antibiotics on respiratory tract. VI. Gentamicin.


Action of antibiotics on respiratory tract. VII. Aminosidin.


The action of arecoline on the superior cervical ganglion of the cat.


The function of dopamine and its antagonism in the caudate nucleus of cats in relation to the stereotyped behaviour.


Sustained release preparations: estimation of plasma concentration in the one compartment open model when release is both immediate and zero order.


The effect of bradykinin on renal arteriography of hypertensive patients.


The mechanism of action of intraventricular carbachol on the body temperature of the rat.


Distribution and metabolism of tritiated yohimbine in mice.


Inhibition of the amidase and kininogenase activities of pancreatic kallikrein by aromatic diamidines and an evaluation of diamidines for their in vivo use.


Effect of duration of administration of cyclophosphamide and steroidal anti-inflammatory drugs on the severity of polyarthritis.


Placental transfer of drugs. IV. Placental transfer of chlorpromazine, pentobarbital and phenylbutazone with fetal electrocardiographic changes as determined by direct lead tracing.


Cyst wall formation and endogenous carbohydrate utilization during synchronous encystment of Phytophthora palmivora zoospores.


Structure and differentiation of the cell wall of Phytophthora palmivora: cysts, hyphae and sporangia.


The requirement of low pH for growth of Thiobacillus thiooxidans.


Continuous culture of thiorhodaceae. Sulfide and sulfur limited growth of Chromatium vinosum.


Inhibition of growth of obligately chemolithotrophic Thiobacilli by amino acids.


Current trends in audiometric practices.


The influence of the intracellular concentration of sodium on the uptake of L-( 14 C)valine by chopped tissue from cerebral cortex. 1. The intracellular concentrations of sodium, potassium, ATP and creatine phosphate in chopped tissue from guinea-pig cerebral cortex were altered by a 10min period of electrical stimulation. 2. The ability of the tissue to take up l-[(14)C]valine and incorporate it into protein was tested at various times after the cessation of electrical stimulation. 3. The restoration of the ability of the tissue to accumulate l-[(14)C]valine correlated closely with the restoration of the resting intracellular concentrations of sodium and ATP.


The hydrolysis by thermolysin of dipeptide derivatives that conatin substituted cysteine. 1. The preparation of protected dipeptides of the form acetylglycylamino acid amides is described, where the amino acid is phenylalanine, leucine, valine, alanine, S-methylcysteine, S-ethylcysteine, S-benzylcysteine and S-phenylcysteine. 2. Kinetic parameters for the thermolytic hydrolysis of these blocked dipeptides are reported. The rate of hydrolysis was fastest when the amino acid was leucine or phenylalanine, slower when it was S-methylcysteine, valine or S-ethylcysteine, much slower when it was alanine, and negligible for S-phenylcysteine or S-benzylcysteine. 3. The results are compared with those for similar dipeptide derivatives with benzyloxycarbonyl and furylacryloyl blocking groups, which are hydrolysed faster.


Effects of metabolic acidosis and starvation on the content of intermediary metabolites in rat kidney. 1. Metabolite contents were determined in freeze-clamped kidney from acidotic and starved rats in order to elucidate the rate-controlling steps which are responsible for the acceleration of gluconeogenesis in these situations. 2. In the kidney of rats which were made mildly acidotic by replacing drinking water with 1.5% ammonium chloride for 7 to 10 days (when the plasma bicarbonate concentration was 20mm) the content of phosphoenolpyruvate was increased from the control value of 35 to 63nmol/g and that of 3-phosphoglycerate from 85 to 154nmol/g. 3. Similar but smaller changes in these metabolites occurred in the kidney of starved rats but there were no such changes in the kidney of rats 12h after an infusion of 0.25m-hydrochloric acid, although plasma bicarbonate concentration fell to about 10mm on this treatment. 4. The renal concentration of glucose 6-phosphate was not raised in rats that received ammonium chloride, but was increased in starved and acutely acidotic rats. 5. The concentrations of alpha-oxoglutarate, malate and citrate were less than half the normal value in the kidney of both groups of acidotic rats. These changes can be accounted for on the basis of equilibrium relationships among reversible reactions, particularly as a result of the rise in intracellular ammonia content. A less marked decrease in alpha-oxoglutarate and malate was found in the kidney of starved rats. 6. The renal cortical cytoplasmic oxaloacetate concentration was calculated to be decreased in acidotic and starved rats. 7. These results are discussed in the light of the known enhancement by acidosis and starvation of renal gluconeogenesis. In particular they support the suggestion that the phosphoenolpyruvate carboxykinase reaction is a site of control of gluconeogenesis in kidney in these conditions.


Isolation and fractionation of glycopeptides from porcine thyroglobulin. 1. Glycopeptides were isolated by gel filtration on Sephadex G-25 and Sephadex G-50 from a Pronase digest of porcine thyroglobulin. 2. Isolated glycopeptides were separated into five main fractions on a column of DEAE-Sephadex A-25. Of these fractions I to III were further purified by SE-Sephadex C-25 or DEAE-Sephadex A-25 column chromatography. Several of the purified glycopeptides were homogeneous on paper electrophoresis. 3. Based on the chemical composition and molecular weight of the fractionated glycopeptides, two distinct types of heterosaccharide chain were demonstrated. 4. One type of the heterosaccharide unit consisted of four to eight residues of mannose and two residues of glucosamine and had a molecular weight of 1000-1700. The other type of unit contained sialic acid, fucose and galactose in addition to mannose and glucosamine and had a molecular weight of about 3600. 5. Mild alkaline treatment of the glycopeptide did not result in the destruction of threonine and serine. 2-Acetamido-1-N-(4-l-aspartyl)-2-deoxy-beta-d-glucopyranosylamine was isolated from partial acid hydrolysates.


The effects of hydrogen ion concentration on the simplest steady-state enzyme systems. Laidler (1955) showed that consideration of the effect of pH on enzymic mechanisms that obey steady-state kinetics leads to the inclusion in the equations of a ;perturbation term' that can introduce curvature into the Lineweaver-Burk plots. He also stated conditions in which this term vanishes. This term can lead to apparent activation by substrate. Further, several cases are shown in which simplification, but not disappearance, of the perturbation term can lead to linearity of Lineweaver-Burk plots. These cases arise when the ionization of groups at the active site either is unaffected or is completely prevented when the enzyme-substrate complex is formed. It is also shown that V((app.)) can vary with pH without a concomitant change in K(m(app.)) in certain cases that obey steady-state kinetics without implying that K(m)=K(s). When the perturbation term is significant, Dixon's (1953) rules for the calculation of pK values will not always apply.


Tautomerism and hydrogen bonding in bilirubin.


The synthesis and decay of histone fractions and of deoxyribonucleic acid in the developing avian brain. 1. The turnover of cerebral histones and DNA after injection of [4,5-(3)H]leucine or [methyl-3-(3)H]thymidine, respectively, was studied in the developing chick. 2. Chromatin was prepared from chick nuclei that had been purified by centrifugation through 1.9m-sucrose. 3. Nuclear proteins were fractionated into three major histone classes, F1 (lysine-rich), F2(b) (slightly lysine-rich) and [F3+F2(a)] (arginine-rich), and a non-histone protein residue. 4. The proportions of the histone classes remained constant throughout the period of development studied. 5. All histone fractions decayed at a similar rate, initially with a half-life of around 5 days, later with a half-life of 19 days. 6. Non-histone proteins from chromatin decayed in a heterogeneous manner with a wide range of half-lives. 7. Short-term labelling studies showed that all histone fractions were synthesized at the same rate. 8. Some non-histone proteins were very rapidly synthesized relative to histones. 9. DNA had a longer half-life than any histone fraction studied. A biphasic exponential decay curve with half-lives of 23 and 50 days was found. 10. It was concluded that the turnover of histones can occur independently of that of DNA and that different histone classes have similar rates of synthesis and decay.


Base pairing equilibria between polynucleotides and complementary monomers.


Spectroscopic studies of random chain and  -helical polypeptides in hexafluoroisopropanol.


Physicochemical studies of oligodextran. I. Molecular weight dependence of intrinsic viscosity, partial specific compressibility and hydrated water.


Circular dichroism of native and reconstituted nucleohistones.


Minor nucleosides in RNA: Optical studies of dinucleoside phosphates containing dihydrouridine.


Rotatory properties of molecules containing two peptide groups: experimental and theoretical results.


Block sequential polypeptides of L-alanine and glycine with D, L-glutamic acid.


The conformation of single-strand polynucleotides in solution: sedimentation studies of apurinic acid.


Molecular orbital calculations on the conformation of polypeptides and proteins. 8. The conformational energy maps and stereochemical rotational states of the asparaginyl, glutaminyl aspartyl and glutamyl residues.


Conformation of poly-S-carboxyethyl-L-cysteine in aqueous solutions.


Conformational changes in the reassembly of MS2 protein subunits.


Calorimetry of rat tail tendon collagen before and after denaturation: the heat of fusion of its absorbed water.


Synthesis and optical studies of isoleucine oligopeptides in solution.


Determination of the diffusion coefficient and molecular weight of Tamm-Horsfall glycoprotein by intensity fluctuation spectroscopy.


Circular dichroism studies of isoleucine oligopeptides in solution.


Hemoglobin Hirose: 2 237(C3) tryptophan yielding serine.


Platelet functional abnormalities: a report of two familial defects in interaction between collagen and platelets and ADP release.


Immune lysis of normal and AET-treated lymphocytes: a study of transmission and scanning electron microscopy.


Antibody to transcobalamin II and B12 binding capacity in patients treated with hydroxocobalamin.


The relationship between spleen colony production and spleen cellularity.


The f number of primary transplanted splenic colony-forming cells.


Proliferation kinetics in epithelium of guinea-pig colon. II. Distribution of proliferating and specialized cells along various crypts.


A quantitative study of the mitotic activity in the subependymal plate of adult rats.


A comparison of metaphase arresting agents and tritiated thymidine. Autoradiography in measurement of the rate of entry of cells into mitosis in the crypts of Lieberkühn of the rat.


The validity of autoradiographic labeling.


An attempt to include "quality of life" in evaluation of survival in bronchial cancer therapy.


Current status of research in artificial support of the circulation.


Sites and thermodynamic quantities associated with proton and metal ion interaction with ribonucleic acid, deoxyribonucleic acid, and their constituent bases, nucleosides, and nucleotides.


Effects of cigarette smoking on hemodynamics at rest and during exercise. Normal subjects.


Frequency of "M-type" globulinemia among a tuberculosis hospital population. A review of 4,216 consecutive electrophoretic paterns.


Diagnosis of left anterior hemiblock in the presence of inferior wall myocardial infarction.


Left ventricular-right atrial shunt due to bacterial endocarditis.


Pulmonary embolism in Landry-Guillain-Barre-Strohl syndrome.


Solitary (localized) pleural mesothelioma. Report of two cases and review of the literature.


The aged lung.

The aged lung.


Diffuse malignant mesothelioma of the pleura: a review of 37 cases.


Increased excitability of the heart induced by electrical stimulation in the absolute refractory period.


Postmyocardial infarction ventricular aneurysm septal tear syndrome.


Calcified cholesterol-containing pleural effusion.


Recurrent spontaneous pneumothoraces in systemic lupus erythematosus.


Phonocardiographic findings in anemia.

Phonocardiographic findings in anemia.


An aberrant systemic artery to the right lung with normal pulmonary tissue.


Milk of calcium fluid in an intrapulmonary bronchogenic cyst.


Bacteriology of the pleural space in pneumothorax simplex.


Rupture of pericardial cyst.

Rupture of pericardial cyst.


Tuberculous coronary arteritis with aneurysm of the ventricular septum.


Pseudocoarctation of aorta associated with aneurysm formation.


Synthesis of 5 S and transfer RNA during embryogenesis in the milkweed bug, Oncopeltus fasciatus.


Developmental expression of alcohol dehydrogenases in maize.


Control of enzyme synthesis in early sea urchin development: aryl sulfatase activity in normal and hybrid embryos.


Analysis of DNA in mason bee sperm (Hymenoptera: Megachilidae).


Evaluation of left ventricular function during routine cardiac catheterization: usefulness of DP-DT measurements in clinical cases.


On the metabolism of prostaglandins E 1  and E 2  in man.


Studies of the metabolism of 5 -cholesta-8,14-dien-3 -ol and 5 -cholesta-7,14-dien-3 -ol in rat liver homogenate preparations.


5-Hydroxy-N-methylpyroglutamate synthetase. Evidence for an  -ketoglutaryl enzyme intermediate from partitioning studies.


Studies on the structure and function of muscle aldolase. V. Molecular characterization of the enzyme from shark (Mustelus canis).


Effect of structural perturbations on the ligand-binding properties of human methemoglobin A.


Nonequivalent binding to human methemoglobin. Thermodynamic and kinetic comparison.


Formyltetrahydrofolate synthetase. Binding of adenosine triphosphate and related ligands determined by partition equilibrium.


The enzymatic N-hydroxylation of an imine. A new cytochrome P-450-dependent reaction catalyzed by hepatic microsomal monooxygenases.


Fluorescence studies of the binding of alkyl and aryl phosphates to rat muscle aldolase.


Correction of COOH-terminal amino acids of human plasma very low density apolipoproteins.


The George Bidder lectures. Experimental biology, pure and applied.


Sound reception in the bush cricket Metrioptera brachyptera (L.) (Orthoptera, Tettigonioidea).


Parental conceptual systems, home play environment, and potential creativity in children.


State and the auditory reactivity of the human neonate.


Strength of dimensional preferences as a predictor of nursery-school children's performance on a concept-shift task.


Smiling in children as a function of their sense of mastery.


Second international symposium on gentamicin, an aminoglycoside antibiotic. Symposium perspectives.


Gentamicin and ampicillin in human bile.


Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States.


Possible nephrotoxicity of gentamicin.

Possible nephrotoxicity of gentamicin.


Renal insufficiency associated with gentamicin therapy.


Therapy with gentamicin for bacteremic infections: results with 53 patients.


Intravenous gentamicin therapy for infections in patients with cancer.


Supplemental antibiotics to enhance the action of gentamicin in pseudomonas and mixed infections.


Use of gentamicin in newborn infants.

Use of gentamicin in newborn infants.


A virulent nosocomial Klebsiella with a transferable R factor for gentamicin: emergence and suppression.


Use of gentamicin in children with cystic fibrosis.


Subtenon injection of gentamicin for bacterial infections of the eye.


Effect of gentamicin on Pseudomonas pseudomallei.


Pharmacokinetics of gentamicin: distribution and plasma and renal clearance.


Gentamicin for septicemia in patients with burns.


The use of gentamicin in peritoneal dialysis. I. Pharmacologic results.


Bacterial resistance to aminoglycoside antibiotics.


Pharmacology of gentamicin in man.

Pharmacology of gentamicin in man.


Fine structure of the antenna and its sensory cone in larvae of Aedes aegypti (L.).


Hemocytoblastoid reaction of thymic subcapsular cells to diphtheria toxoid.


Structural and physiological changes associated with the growth of avian fast and slow muscle.


Effect of excessive levels of lysine and threonine on the metabolism of these amino acids in rats.


Alpha- and gamma-tocopherol in the rat: in vitro and in vivo tissue uptake and metabolism.


Cellular growth in experimental intrauterine growth retardation in rats.


Distribution of  14 C-cyclamate in the lactating rat.


Hypertension in young rats following choline deficiency in maternal diets.


Endogenous zinc excretion and  65 Zn metabolism in Holstein calves fed intermediate to high but nontoxic zinc levels in practical diets.


Chemical pathology of acute amino acid deficiencies: reversibility of the pathologic changes in rats force-fed a threonine-devoid diet.


A search for triple X females in a fertile population.


Metabolic fate of 1,3-butanediol in the rat: liver tissue slices metabolism.


The regularity of early menstrual cycles.


Pregnancy results following treatment with clomiphene citrate.


Vaginal adenosis: clinical and pathological features with special reference to malignant change.


Carcinoid tumours of the ovary.

Carcinoid tumours of the ovary.


Carcinoma of the cervix in childhood. (A report of two cases).


Use of osmometry in the preoperative and postoperative management of the newborn.


Muscle surface pH as a monitor of tissue perfusion and acid-base status.


Use of ultrasonic nebulizer during anesthesia.


Effect of blood viscosity on pulmonary vascular resistance.


The conservative management of splenic trauma.


Pathophysiology and management of acute corrosive burns of the esophagus: results of treatment in 285 children.


Liver trauma in children.

Liver trauma in children.


Neuroblastoma: an assessment of therapy in reference to staging.


Chronic granulomatous disease of childhood: surgical considerations.


Surface-induced deep hypothermia in cardiac surgery.


Staged repair of huge ventral hernias.

Staged repair of huge ventral hernias.


Vascularized appendiceal transplants in biliary and urinary tract replacement.


Arteriovenous shunts for hemodialysis in infants and children.


A procedure for lengthening the phallus in boys with exstrophy of the bladder.


Transatrial closure of high-pressure, high-resistance ventricular septal defects.


Pyloric duplication masquerading as hypertrophic pyloric stenosis.


Gastric division: a surgical adjunct in selected problems with esophageal anomalies.


Neonatal aortic occlusion with successful embolectomy.


Acquired intestinal atresia.

Acquired intestinal atresia.


Esophagram with a barium-filled Penrose drain.


Experience with urea in invert sugar for the treatment of cerebral malaria.


Urolithiasis in the rat.

Urolithiasis in the rat.


Technique for oral intubation of wild rats.


Mucosal cysts in the gastrointestinal tract of beagle dogs.


Bone marrow biopsy in the rabbit.

Bone marrow biopsy in the rabbit.


Rigid polythene containers for the radiation sterilization of supplies for germ-free animal isolators.


Apparatus for collecting faeces and urine from rats in metabolic experiments.


Fire-risk-free anaesthesia of rodents with halothane.


Eradication of Tyzzer's disease in a colony of barrier-maintained mice.


The production of experimental vitamin A deficiency in rats and mice.


Influence of pH on phenotypic reversal of T4 phage amber mutations by 5-fluorouracil.


Effect of phenobarbital and pregnenolone-16 -carbonitrile on the toxic and antineoplastic action of cyclophosphamide.


First aid in mental distress. 1. Mental functions.


The anaemias. 2. Pernicious anaemia.

The anaemias. 2. Pernicious anaemia.


The gentle art of visiting.

The gentle art of visiting.


A chronic schizophrenic and her child.

A chronic schizophrenic and her child.


Internal derangements of the knee.

Internal derangements of the knee.


Birth interval and malnutrition.

Birth interval and malnutrition.


Superstitions.

Superstitions.


Nursing staff sickness and absenteeism in the medical and paediatrics unit.


Knock...knock--who's there?--Salmon.

Knock...knock--who's there?--Salmon.


A case of multiple sclerosis.

A case of multiple sclerosis.


Mechanical aids to nursing paraplegics.

Mechanical aids to nursing paraplegics.


First aid in mental distress. 2. Thinking and intelligence.


Are women the weaker sex?

Are women the weaker sex?


The anaemias. 3. Haemolytic anaemia.

The anaemias. 3. Haemolytic anaemia.


Belt-up--the seat belt story.

Belt-up--the seat belt story.


The anaemias. 4. Aplastic anaemia.

The anaemias. 4. Aplastic anaemia.


First aid in mental distress. 3. Emotion and personality.


Industrial Relations Act and nurse administrators.


The effect of footwear on venous return.


Fluoresceinoscopy of retinal holes in retinal detachment.


Urinary excretion of estrogens in women with bleeding during climacterium and after menopause.


The effect of caffeine on the development of atherosclerosis in pig.


The formation of internal lining of arterial prostheses from free graft of parietal peritoneum in dog.


The effect of hypnosis and hypnotic suggesion on the blood flow in the extremities.


Myokinase activity in myocardial infarction.


Sodium and potassium excretion in sweat of patients with arterial hypertension.


The effect of neuroleptanalgesia II on acid-base balance and blood oxygenation in patients with myocardial infarction.


Renal split function studies in patients with arterial hypertension and renal artery stenosis.


Urokinase (UK) activity in acute renal failure.


Urine antitrypsin activity (UAA) in the course of acute renal failure.


Computation of the number of diabetics, as well as of diabetic genotypes and of the frequency of diabetic alleles in the Polish population above 14 years of age.


The use of natural secretin in the determination of maximal pancreatic secretion in man.


Clinical aspect of the studies of metabolic precursors of methylmalonic acid in vitamin B 12  deficiency.


Muramidase activity in granulocytopenia.


The desmofibrinogenic activity of tissues.


Significance of the thiol groups in the formation of desmofibrin.


Hepatic function during considerable sport exercise in the light of the bromsulphthalein (BSP) test.


Measurements of pulmonary wedge pressure after inhalation of amyl nitrite as a diagnostic test in mitral stenosis.


Application of Haemaccel in the extracorporeal circulation during heart surgery.


Retention of sodium and water in patients after mitral commissurotomy.


Mitral commissurotomy as an emergency procedure.


Thoracotomy in the treatment of so-called spontaneous pneumothorax.


Detection of PAS in saliva by means of paper- and test tube tests.


Morphological studies on the inner lining formed from free peritoneal graft in aortic prostheses in dogs.


Experimental studies on the effect of disturbances of calcium metabolism on the kidney and other organs of white rat.


A dinoflagellate with both a mesocaryotic and a eucaryotic nucleus. I. Fine structure of the nuclei.


Ultrastructure and ion transport in gill epithelium of the crayfish, Astacus leptodactylus Esch.


Flagellar attachment and detachment of Crithidia fasciculata to the gut wall of Anopheles gambiae.


Vinblastine-induced precipitation of phloem proteins in vitro.


Insulin molecules: the extent of our knowledge.


Potentiometric titration and conformation of synthetic and natural polyelectrolytes.


Relationship of nuclear membranes with filaments and microtubules.


Partial defect of the pericardium associated with a bronchogenic cyst.


Platelet aggregation in washed suspensions.


Political orientation and riot participation.


A comparative study of galanthamine hydrobromide and atropine-neostigmine in conscious volunteers.


Relationships between plant viruses and their aphid and leafhopper vectors.


The role of N-oxidation products of aromatic amines in the induction of baldder cancer in the dog.


Some observations on severe human poisonings with organophosphate pesticides.


Erythrocyte enzymes in experimental lead poisoning.


On the urinary excretion of nitrazepam and its metabolites.


Kinetic specificity in papain-catalysed hydrolyses. The specificity of the proteolytic enzyme, papain, for the peptide bond of the substrate adjacent to that about to be cleaved and for the acyl residue of some N-acylglycine derivatives is manifest almost exclusively in the formation of the acyl-enzyme from the enzyme-substrate complex. Models for the enzyme-substrate complex and acyl-enzyme intermediate are suggested that account for these observations. In particular it is suggested that the peptide bond of the substrate adjacent to that about to be cleaved, is bound in the cleft of the enzyme between the NH group of glycine-66 and the backbone C=O group of aspartic acid-158, and provides a sensitive amplification mechanism through which the specificity of the enzyme for hydrophobic amino acids such as l-phenylalanine is relayed. It is also suggested that the distortion in the enzyme-substrate complex and the binding of the peptide bond adjacent to that about to be cleaved are also linked and behave co-operatively, the distortion of the protein facilitating binding and the stronger binding facilitating distortion. The results imply that between the enzyme-substrate complex and the acyl-enzyme a relaxation of the protein conformation must occur.


pH-dependence and structure-activity relationships in the papain-catalysed hydrolysis of anilides. The pH-dependence of the Michaelis-Menten parameters for the papain-catalysed hydrolysis of N-acetyl-l-phenylalanylglycine p-nitroanilide was determined. The equilibrium binding constant, K(s), is independent of pH between 3.7 and 9.3, whereas the acylation constant, k(+2), shows bell-shaped pH-dependence with apparent pK(a) values of 4.2 and 8.2. The effect of substituents in the leaving group on the acylation constant of the papain-catalysed hydrolysis of hippuryl anilides and N-acetyl-l-phenylalanylglycine anilides gives rise in both series to a Hammett rho value of -1.04. This indicates that the enzyme provides electrophilic, probably general-acid, catalysis, as well as the nucleophilic or general-base catalysis previously found. A mechanism involving a tetrahedral intermediate whose formation is general-base-catalysed and whose breakdown is general-acid-catalysed seems most likely. The similarity of the Hammett rho values appears to exclude facilitated proton transfer as a means through which the specificity of papain is expressed.


Catalytic activity of  -chymotrypsin in which histidine-57 has been methylated. The properties of a derivative of alpha-chymotrypsin in which histidine-57 has been methylated have been examined. Although the modified enzyme binds substrate with the same affinity as does native alpha-chymotrypsin, acylation and deacylation occur at much decreased rates. As for native alpha-chymotrypsin, a basic group of pK(a) approx. 7 is involved in both acylation and deacylation. The significance of these results is considered in relation to the normal function of histidine-57.


Hydrolytic and alcoholytic dephosphorylation of nucleotides by acid phosphatase in the presence of ethanol. The effect of ethanol on the activity of acid phosphatase from wheat germ was studied, by using ribonucleoside monophosphates as the enzyme substrates. The nucleotides were effectively degraded to the corresponding nucleosides in the presence of ethanol at all concentrations tested, including a 96% (v/v) solution. However, the nucleotide dephosphorylation was accompanied by the liberation of orthophosphate only when the concentration of ethanol in the assay mixture did not exceed 15%. No inorganic phosphate was liberated when ethanol was present at higher concentrations. Instead, monoethyl phosphate was formed in quantities expected for orthophosphate. The results are explained in terms of phosphatase-catalysed alcoholysis.


Cytochrome P-450 and hydroxylating activity of microsomal preparations from whole houseflies. 1. A new microsomal preparation, obtained from whole houseflies is described in terms of its cytochrome P-450 content and its hydroxylating activity. 2. Microsomes prepared from whole-fly brei, obtained with the aid of a mortar (a procedure that avoids the destruction of sarcosomes), contain 0.265nmol of cytochrome P-450 and hydroxylate naphthalene at a rate of 28.5nmol/mg of microsomal protein in 30min at 30 degrees C. This corresponds to 104nmol of naphthalene hydroxylated/nmol of cytochrome P-450. This is the highest rate ever reported for housefly and rat liver microsomal preparations. 3. Microsomal fractions prepared by procedures that do not retain the integrity of sarcosomes show the presence in the CO-difference spectrum of a 428nm peak. This cytochrome is associated with sarcosomal microsomes and it may be involved in the inhibition of insect microsomal mixed-function oxidases, although other factors cannot be discarded at present. 4. The inability to show cytochrome P-450 in microsomal fractions isolated from whole houseflies by other procedures may be at least partially due to a masking effect brought about by contamination with the sarcosomal cytochrome.


Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver. 1. The activity of rat liver microsomal drug-metabolizing enzymes was determined at various ages between 6 and 100 days post natum. The enzymes studied were: aromatic hydroxylases by using as substrate biphenyl, which is metabolized by oxidation to 2- and 4-hydroxybiphenyl; nitroreductase by using p-nitrobenzoate as substrate, which is metabolized by reduction to p-aminobenzoate; glucuronyl synthetase by using 4-methylumbelliferone as the substrate, which is conjugated to give 4-methylumbelliferone glucuronide, and cytochrome P-450, which is regarded as the major terminal mixed-function oxidase in hepatic microsomal hydroxylations. 2. The activity of biphenyl 2-hydroxylase reached a peak at 21 days, biphenyl 4-hydroxylase and 4-methyl glucuronyl transferase at 24 days, cytochrome P-450 at 31 days, and p-nitrobenzoate reductase at 38 days of age. After the peak activity had been reached, the activity of each enzyme decreased with age, and in the case of biphenyl 2-hydroxylase the activity fell to a negligible value at 52 days of age. 3. Neither the addition of Triton X-100 to the incubation medium nor the treatment of the animals with phenobarbital resulted in any increase in the activity of biphenyl 2-hydroxylase at 52 days of age. 4. The activity of biphenyl 2-hydroxylase was threefold higher in rats fed on a synthetic diet than in rats fed on a commercial stock diet. 5. These findings are discussed.


Oxidative phosphorylation. The relation between the specific binding of trimethylytin and triethyltin to mitochondria and their effects on various mitochondrial functions. 1. A binding site (site 1) is present in mitochondria with affinity for trimethyltin and triethyltin adequate for a site to which they could be attached when the processes of energy conservation are inhibited. 2. The quantitative relationships between the binding of trimethyltin and triethyltin to site 1 and their effects on various mitochondrial functions have been examined. 3. ATP synthesis linked to the oxidation of pyruvate, succinate and intramitochondrial substrate, ATP synthesis and oxygen uptake (succinate or pyruvate as substrate) stimulated by uncoupling agents are all inhibited by trimethyltin and triethyltin; when inhibition is less than 50% the ratio (percentage inhibition)/(percentage of binding site 1 complexed) is approx. 10:1. 4. ATP synthesis linked to the oxidation of reduced cytochrome c (ascorbate+NNN'N'-tetramethyl-p-phenylenediamine), ATP hydrolysis and oxygen uptake in the presence of low concentrations of trimethyltin and triethyltin approach zero activity as the proportion of binding site 1 complexed approaches 100%. 5. Possible interpretations of these findings are discussed with reference to published arrangements for coupling of electron transport to ATP synthesis and also to our present knowledge of the chemical and biological specificity of trialkyltin compounds.


Protein and carbohydrate moieties of a preparation of  -lactamase II. 1. A crystalline preparation of beta-lactamase II has been separated into two moieties by gel filtration on a column of Sephadex G-100. 2. The first moiety consisted mainly of carbohydrate and showed virtually no beta-lactamase activity. 3. The second moiety was a protein of molecular weight 22500, which was enzymically active. 4. The protein moiety, like the original protein-carbohydrate complex, required Zn(2+) for beta-lactamase activity. It did not differ significantly from the complex in its behaviour to a number of cephalosporin substrates, but was less stable to heat than the complex. 5. About 30% of the total beta-lactamase activity was lost when the protein-carbohydrate complex was separated into the two moieties. This activity was regained when the protein and carbohydrate moieties were mixed, but the mixture did not show the heat stability of the original complex.


A suggested simple chromatographic method for confirming the amino acid analyses of small peptides.


Structure of glycoproteins of human erythrocytes. Alkali-stable oligosaccharides. Studies have been made on the oligosaccharide residues of the alkali-stable carbohydrate-protein linkage of sialoglycopeptides derived from human erythrocytes. Four glycopeptides were isolated after alkaline borohydride treatment and Pronase digestion of MN-active sialoglycopeptides. The structure of one of these glycopeptides (GPIV) has been studied by sequential hydrolysis with specific glycosidases. Glycopeptide GPIV contained (per mol): 1mol of fucose, 1mol of sialic acid, 3mol of galactose, 3mol of mannose, 4mol of acetylglucosamine, 1mol of aspartic acid and fractional amounts of threonine, serine and glycine. The molecular weight of the glycopeptide was estimated to be 2330 by gel filtration. On the basis of glycosidase-digestion results, a tentative structure is proposed for the oligosaccharide moiety of glycopeptide GPIV.


Acylation of carcinogenic hydroxamic acids by carbamoyl phosphate to form reactive esters. 1. Acylation of 2-(N-hydroxyacetamido)fluorene and several other aromatic hydroxamic acids by carbamoyl phosphate was studied and compared with the acylating activity of acetyl-CoA. Acetyl phosphate was also studied. 2. The carbamoylation reaction had a pH optimum of 4.5. The reaction had a lag period of 1h and was then linear for 4h. This linearity ranged between 0.5mm- and 8mm-carbamoyl phosphate concentration. 3. At pH7.5, acetyl-CoA was the most powerful acylating agent. Acetyl phosphate was a weaker acylating agent than either of the others. 4. Among the various hydroxamic acids tested with acetyl-CoA and carbamoyl phosphate at pH.7.5, 2-(N-hydroxyacetamido)fluorene was the most reactive. On the other hand the less reactive N-hydroxy derivatives of 2-acetamidonaphthalene, 2-acetamidophenanthrene and 4-acetamidostilbene reacted severalfold more with carbamoyl phosphate than with acetyl-CoA. 5. It is suggested that carbamoylation of aromatic hydroxamic acids might be one of the final activation steps in carcinogenesis by these compounds.


N-(5'-phosphopyridoxyl)glutamic acid and N-(5'-phosphopyridoxyl)-2-oxopyrrolidine-5-carboxylic acid and their action on the apoenzyme of aspartate aminotransferase. 1. N-(5'-Phosphopyridoxyl)-l-glutamic acid (P-Pxy-Glu, compound I) is readily converted at pH3 into a substance (P-Pxy-Glp, compound II) characterized as N-(5'-phosphopyridoxyl)-2-oxopyrrolidine-5-carboxylic acid. 2. The u.v., i.r. and fluorescence spectra of P-Pxy-Glu and P-Pxy-Glp have been determined; from the u.v. spectra their pK values have been found and compared. 3. The apoenzyme of aspartate aminotransferase is rapidly and irreversibly inactivated by P-Pxy-Glu, but is inactivated more slowly by P-Pxy-Glp. The complex with P-Pxy-Glp is stable enough to be isolated, but it is slowly reactivated in the presence of excess of pyridoxal phosphate. 4. The u.v. spectrum of the complex of apoenzyme and P-Pxy-Glp suggests that it contains a hydrogen bond between the phenolic hydroxyl group and the pyrrolidone nitrogen; this specifies the conformation of most of the molecule of P-Pxy-Glp. This conformation is similar to that previously postulated for the enzyme-glutamate complex except for the side chain of glutamate. Hence both the affinity of P-Pxy-Glp for the apoenzyme and the fact that it is more easily removed than P-Pxy-Glu are explicable.


Factors affecting the activity of oestradiol hydroxylase in rat liver microsomal subfractions. 1. Oestradiol hydroxylase activity, as measured by the formation of water-soluble products, was significantly higher in the smooth endoplasmic reticulum of rat liver than in the rough membrane. 2. The isolated membrane fractions retained their activity for at least 6 months if stored at -30 degrees C and were more stable in tris-HCl than in sodium phosphate buffer. 3. The stability of the oestradiol-hydroxylating system was inversely related to lipid peroxidation and was decreased by phospholipases and deoxycholate, which damage the reticular membranes. Ribonuclease had no effect on this system. 4. Added polyribosomes did not influence the metabolism of oestradiol in the smooth membranes but some inhibition in the yield of water-soluble metabolites was produced by corticosterone. 5. The effect of spermine on microsomal hydroxylation was investigated. It is proposed that this polyamine acts either by direct activation of the enzyme complex or by inhibition of the lipid peroxidase pathway in a linked system rather than by stabilization of the reticular membranes.


Structure-activity relationships for N,N'-bis(dichloroacetyl) diamines and substituted naphthoquinones in the inhibition of mitochondrial electron transport.


Inhibition of morphine metabolism by catechol in the chicken kidney.


Assay and rapid disappearnace of brocresine activity in blood.


Location of chloroquine binding sites in Plasmodium berghei.


Studies on enzymatic hydrolysis of aziridines. I. The conversion of 2 ,3 -imino-5 -cholestane into 2 -amino-3 -hydroxy-5 -cholestane by liver microsomes.


Fatty acid oxidation in mitochondria isolated from rat submandibular salivary glands.


Iron-containing proteins in Chromatium. II. Purification and properties of cholate-solubilized cytochrome complex.


Thermodynamics of the primary and secondary photochemical reactions in Chromatium.


Oxidative phosphorylation in Moniezia muscle mitochondria.


Distribution of variable fluorescence among subchloroplast fractions.


Action of hydroxylamine in the red alga Porphyridium cruentum.


Sensitive fluorescence method for the determination of chlorophyll a-chlorophyll b ratios.


Physicochemical study of structural proteins of chloroplast from Zea mays L.


On the inhibition of  -oxobutyrate utilization by fatty acids in rat liver mitochondria.


Photosystem I and II chlorophyll-protein complexes of higher plant chloroplasts.


Compatibility of the components of nitrogenase from soybean bacteroids and free-living nitrogen-fixing bacteria.


Flash activation kinetics and photosynthetic unit size for oxygen evolution using 3-nsec light flashes.


The spectral properties of the b cytochromes in intact mitochondria.


Far-infrared spectra of some globular proteins.


Light-scattering and potentiometric-titration studies of poly-L-tyrosine in aqueous solution.


A non-perturbation method for the optical properties of helical polymers.


Electro-optical properties of nucleic acids and nucleoproteins. 3. Kramers-Kronig relationships in linear birefringence and dichroism. Application to a DNA-proflavine complex.


The effect of adjacent charges on the kinetics of rotation of the peptide bond.


Oligonucleotide studies: optical rotatory dispersion of normal and 2'-O-methylated diribonucleoside monophosphates.


The binding of Mg++ ions to polyadenylate, polyuridylate, and their complexes.


Volume changes accompanying the complex formation of polyadenylic and polyuridylic acids.


Light scattering and hydrodynamic properties of linear and circular bacteriophage lambda DNA.


Poly( -p-nitrobenzyl-L-glutamate): synthetic aspects, sedimentation, and viscosity studies.


Potentiometric titration of poly-S-carboxyethyl-L-cysteine.


Magnetic circular dichroism study on synthetic polynucleotides, bacteriophage structure, and DNA's.


Nuclear magnetic resonance and optical spectroscopic studies of block copolymers of polypeptides. I. Block copoly((benzyl-L-glutamate) n : (benzyl-L-aspartate) m ).


Volume and sound velocity changes accompanying the  -helix to  -form and coil to  -helix transitions in aqueous solution.


On the conformations of poly-N-methyl-L-alanine (PNMA) in solution.


An infrared study on the conformation of poly-L-proline in concentrated aqueous salt solutions.


An infrared study of unordered poly-L-proline in CaCl 2  solutions.


Evaluation of RNA conformation from circular dichroism and optical rotatory dispersion data.


The pressure dependence of the buoyant density of DNA as a function of base composition.


Persistence length of DNA from hydrodynamic measurements.


Simplification of the empirical relationship between melting temperature of DNA, its GC content and concentration of sodium ions in solution.


The effect of mercuric ion on the DNA-methylene blue complex.


Ultrasonic absorption of DNA solutions: influence of pH.


[Ultrasonic studies in relation to the helix-coil transition in aqueous solutions of poly-L-lysine].


Method for the automatic correction of scattering in absorption spectra by using the integrating sphere.


Electric field effect on poly-alanine and poly-hydroxyproline film conformation.


Are there two types of post-traumatic retrograde amnesia?


Myoclonus and photic-induced seizures in Alzheimer's disease.


Age and susceptibility to reduction in life expectancy: an analysis of proposed mechanisms.


Study of lactic dehydrogenase activity and isoenzyme pattern in myasthenia gravis.


Mitochondrial studies in senescent mice. II. Specific activity, buoyant density, and turnover of mitochondrial DNA.


Linked cross-sectional study of age-related changes in human-blood chemistry, haematology and circulatory function.


RNA-protein ratios of canine pancreatic microsomes and their subfractions as a function of age.


Cystein-S 35  absorption in old rats.

Cystein-S 35  absorption in old rats.


Stimulation of the hemagglutinin response of aged mice by cell-free lymphoid tissue fractions and bacterial endotoxin.


Further notes on the life span of the teleost, Oryzias latipes.


Memory: interaction of stimulus and organismic factors.


What the development of short-term memory is.


Developmental changes in visual information processing and short-term visual memory.


Some thoughts on how children learn to remember.


Pre-diabetes.

Pre-diabetes.


Detection of Australia antigen in Indian childhood cirrhosis.


Patent ducts arteriosus with pulmonary hypertension.


Effecting "death with dignity".

Effecting "death with dignity".


Phototherapy for hyperbilirubinaemia.

Phototherapy for hyperbilirubinaemia.


Morbidity pattern in children under five in a rural community in Haryana.


Changing concepts of death.

Changing concepts of death.


Serum protein fractions during the first year of life.


Leukemia in children.

Leukemia in children.


Pulmonary stenosis with intact ventricular septum and tricuspid regurgitation--clinical and haemodynamic characteristics.


A toxicologic view of marijuana.

A toxicologic view of marijuana.


Juvenile amyotrophic lateral sclerosis.

Juvenile amyotrophic lateral sclerosis.


Services for the preschool child.

Services for the preschool child.


Radical mastectomy for carcinoma of the breast.


The preparation and storage of carbon-11 labelled gases for clinical use.


Use of Aquasol scintillator mixture for liquid scintillation counting of beta radioactivity in biological tissue.


A high pressure noncatalytic method for cyclotron production of fluorine-18.


Methods for using the conventional FeSo 4  dosimeter to measure doses below 1000 rads.


The processing and interpretation of data by a semiconductor radiation needle-detector.


The preparation of carrier-free  203 Pb for medical use.


Some factors to be considered in moving table radiotherapy.


Group A beta hemolytic streptococcal bacteremia. Review and report of 14 cases.


Denaturation of tropomyosin by guanidine hydrochloride.


The solid-phase synthesis of alpha-melanotropin.


Human ceruloplasmin as a polymorphic glycoprotein. Tryptic glycopeptides from two forms of the protein.


Structural changes involved in the folding of proinsulin.


Study of hydrogen bonds in amino acids and peptides.


Major VCG systems proposed in the USA.

Major VCG systems proposed in the USA.


Diagnostic value of P wave in lead V in chronic obstructive pulmonary disease.


Left posterior hemiblock.

Left posterior hemiblock.


Normalisation of a bundle branch block pattern in early beats. The "supernormal" phase of intraventricular conduction intraventricular block due to phase 4 diastolic depolarisation.


The electrocardiogram of healthy young Chinese and Malay men.


Idioatrial tachycardia.

Idioatrial tachycardia.


A stimulator control unit for use in cardiac research.


The relation of QRS amplitude to the frontal QRS axis and the heart-electrode distance.


Diagnostic changes of acute myocardial infarction in the electrocardiogram and vectorcardiogram with coexisting complete left bundle branch block.


Electrocardiographic abnormalities in generalized tetanus.


Two observations regarding pervenous atrial pacing from the coronary sinus.


The elimination of turnaround time in routine ECG processing.


Lymphocyte membrane dynamics. Metabolic release of cell surface proteins. Cell surface proteins of normal and neoplastic lymphocytes were labeled with iodide-(125)I by lactoperoxidase-catalyzed iodination. Incubation of (125)I-labeled iodide cells in vitro resulted in the release of iodinated surface proteins at a rapid rate which was dependent on cellular respiration and protein synthesis. Comparisons by disc electrophoresis showed a marked similarity between urea-soluble surface proteins extracted from iodinated cells and iodinated material released by the cells during in vitro incubation. The rate of release of cell surface proteins from thymus cells was three times faster than that of spleen cells or bone marrow-derived thoracic duct lymphocytes. In addition, different proteins were released at different rates as evidenced by the rate of release of (125)I of rabbit anti-mouse immunoglobulin specifically bound to mouse spleen cells and comparisons by disc electrophoresis of urea-soluble iodinated surface proteins extracted from cells before and after incubation. The results suggest that a dynamic state exists at the cell surface. The possible role of the release of cell surface proteins in cell regulation and communication is discussed.


Specific immune response genes of the guinea pig. 3. Linkage of the GA and GT immune response genes to histocompatibility genotypes in inbred guinea pigs. The ability of guinea pigs to form immune responses specific for each of the random copolymers, L-glutamic acid and L-alanine (GA) and L-glutamic acid and L-tyrosine (GT), is under the control of distinct autosomal dominant genes. By testing for the ability to respond to these copolymers among the progeny from the reciprocal backcross mating of responder (2 x 13)F(1) animals with the appropriate nonresponder parental strain, we have demonstrated that different unigenic autosomal dominant traits control the ability to respond to GA and GT respectively. The data further shows that the GA gene is linked to the poly-L-lysine (PLL) gene and to the locus determining the major strain 2 histocompatibility specificities and that the GT gene is linked to the locus controlling the expression of major strain 13 histocompatibility specificities. Analysis of the inheritance of the GT and PLL genes among the offspring from a mating of responder (2 x 13)F(1) guinea pigs with random-bred guinea pigs unable to respond to GT or PLL demonstrate that these genes segregate away from each other. Thus, the PLL gene and the genes to which it is linked, the GA gene and the major strain 2 histocompatibility locus, behave as alleles or pseudoalleles to the GT gene and the major strain 13 histocompatibility locus.


Enhancement of heme and globin synthesis in cultured human marrow by certain 5 -H steroid metabolites. These studies demonstrate that certain sex steroid metabolites are capable of significantly stimulating the synthesis of both heme and globin in cultured human bone marrow cells. These compounds, which are maximally effective at a concentration of 3 x 10(-8)M, are steroids of the C(19) and C(21) neutral type; share a common 5beta-H (A:B cis) configuration; and are derived from the in vivo biotransformation of testosterone or progesterone, or their intermediates, in man. Since these steroid metabolites have been shown to be capable in other systems of inducing the synthesis of delta-aminolevulinic acid synthetase, the limiting enzyme in the heme biosynthetic pathway, it is hypothesized that their action on human erythroid precursor cells is directed similarly at this enzymatic step leading thereby to increased heme production with consequent stimulation of globin synthesis. This steroid action is independent of erythropoietin, and since these compounds are effective at extremely low concentrations, it is suggested that they may play a physiologic role in the regulation of human erythropoiesis.


A blood coagulation abnormality in rabbits deficient in the sixth component of complement (C6) and its correction by purified C6. Evidence for the involvement of the sixth component of complement (C6) in normal blood coagulation is provided by the description of a coagulation abnormality in rabbits with a genetic C6 deficiency and by its correction with highly purified preparations of C6. Whole blood clotting time in glass or plastic was prolonged and prothrombin consumption was decreased in blood from the deficient animals. Other parameters of blood coagulation were normal, including prothrombin time, partial thromboplastin time, specific clotting factor activities, platelet factor III function, platelet count, and bleeding time. Clotting time and prothrombin consumption became normal when physiologic amounts of highly purified C6 were added to the deficient blood. Partial consumption of C6 hemolytic activity, with a time course similar to the consumption of prothrombin, was demonstrated during the clotting of normal human blood.


Histocompatibility specificity.

Histocompatibility specificity. The lymph node cells from all L-glutamic acid and L-tyrosine (GT) responder random-bred guinea pigs were susceptible to lysis by strain 2 anti-strain 13 isoantisera in the presence of complement. These same antisera were cytolytic for lymph node cells of only some of the GT nonresponder animals. However, after absorption with cells, from a nonresponder guinea pig, susceptible to lysis, the anti-strain 13 antisera were no longer able to lyse cells from any GT nonresponder guinea pigs while retaining a large measure of their cytolytic activity for cells of all GT responder guinea pigs. Thus, at least two major strain 13 histocompatibility specificities are expressed on the cells of random-bred guinea pigs. The genetic locus controlling the expression of only one of those strain 13 histocompatibility specificities is linked to the GT immune response gene.


Effects of bimodal stimulus presentation on tracking performance.


Speed-accuracy trade-off with different types of stimuli.


Cholesterol metabolism in the macrophage. I. The regulation of cholesterol exchange. The cholesterol metabolism of homogeneous populations of mouse peritoneal macrophages was evaluated under in vitro conditions. Macrophages are rich in free cholesterol and maintain a constant cholesterol to protein ratio (12 microg cholesterol/mg protein). No detectable cholesterol ester was present within the cell. More than 95% of total cholesterol was membrane associated and the majority was present in subcellular fractions containing lysosomes and plasma membrane. Less than 0.1% of cell cholesterol was synthesized from acetate-1-(14)C. During in vitro cultivation, macrophages rapidly exchanged their membrane cholesterol with that of lipoproteins of calf serum. About 30% of the cell cholesterol was exchanged per hour in 20% serum medium, and exchange was nearly complete by 5 hr. Exchange proceeded in a rapid exponential phase followed by a slower phase. Calculations based on a two compartment model indicated that the rapidly exchanging cholesterol compartment represented 60-70% of the total cell cholesterol, and the slowly exchanging compartment accounted for 30-40%. The relationship between serum lipoprotein concentration and exchange rate exhibited first-order kinetics. The rate was determined by thermal energy, in keeping with a Q(10) of 2, and an activation energy of 12 kcal/mole. Exchange was independent of bulk transport of lipoproteins by pinocytosis and phagocytosis, and was not linked to energy metabolism. The alpha-lipoproteins were the major class of proteins of calf serum participating in exchange.


Spatial parameters of eye-hand adaptation to optical distortion.


Hemiretinal effects in tachistoscopic letter recognition.


Response mechanisms in detection experiments.


Test of the propriety of the traditional discriminative control procedure in Pavlovian electrodermal and plethysmographic conditioning.


Comparison of trace and delay classical eyelid conditioning as a function of interstimulus interval.


Experiments with the stimulus suffix effect.


Encoding time from iconic storage: a single-letter visual display.


Change in convergence and retinal disparities as an explanation for the wallpaper phenomenon.


Perception of rotation in figures with rectangular and trapezoidal features.


Retroactive masking without spatial transients.


The changing pattern of Hirschsprung's disease.


Role of collateral behavior in temporal discrimination performance and learning in rats.


Physiological basis of diuretic drugs.

Physiological basis of diuretic drugs.


Ear differences and delayed auditory feedback: effects on a speech and a music task.


Role of a sports physician.

Role of a sports physician.


Stone in the upper urinary tract.

Stone in the upper urinary tract.


X-ray examination of the upper gastrointestinal tract. A problem in the provincial hospitals.


The effects of prostaglandin E 1  on renal function.


Erythrocyte glucose-6-phosphate dehydrogenase activity in thalassemia and in hemoglobin E.


Hypertrophic polyneuropathy. Report of a case.


Candida guilliermondii septicemia.

Candida guilliermondii septicemia.


Reye's syndrome. A major disease problem in Thailand.


Selective celiac angiography in amebic liver abscess and opisthorchiasis of the liver.


Perforation of bicornuate uterus by Lippes loop.


Frame-mounted homografts for mitral valve replacement.


Five-year experience with the Smeloff-Cutter mitral prosthesis.


Closed valvulotomy for calcific mitral stenosis.


Open mitral commissurotomy: results of 100 consecutive cases.


The contribution of cuff volume and pressure in tracheostomy tube damage.


Pericardiectomy for recurrent pericarditis.


Management of persistent bronchopleural fistulas.


The surgical implications of intracavitary mycetomas (fungus balls).


Body fluid shifts after cardiopulmonary bypass. I. Effects of congestive heart failure and hemodilution.


Respiratory and metabolic alkalosis and myocardial contractility.


Pericardial patch enlargement of the aortic outflow tract.


Intrapleural pacemaker generator in children.


Changes in serum ionic calcium during cardiopulmonary bypass with hemodilution.


A simple method of repairing fractured pacemaker electrodes.


Hydatid disease of the lung.

Hydatid disease of the lung.


Bronchial avulsion: successful repair after bilateral pneumothorax.


An evaluation of surgical interruption and spontaneous return of the systemic arterial circulation of the lung.


Study with mescaline-8-C14 in mice: effect of amine oxidase inhibitors on metabolism.


Evidence for a specific monoamine oxidase associated with sympathetic nerves.


Effects of some cholinergic and anticholinergic drugs injected intracerebrally to the midline pontine area.


Selective effect of diazepam on certain central sympathetic components.


Effects of microiontophoretic application of imipramine on single neurones in the brain stem.