The effect of local anesthetics on the central nervous system toxicity of hyperbaric oxygen.


Fine structure of neurons and synapses in the central nervous system.


Personality characteristics of innovative and non-innovative teachers.


Attitudes of mental health professionals toward homosexuality and its treatment.


Recidivism among juvenile parolees.

Recidivism among juvenile parolees.


Ammons' quick test as a measure of adult intelligence in a psychiatric sample.


Anxiety and dogmatism.

Anxiety and dogmatism.


Frontal cortex lesions and fixed-interval acquisition in the rat.


Internal vs external control and magnitude of aggression toward self and others.


Bitter and sweet saccharin preferences as a function of food deprivation.


Suicide and homicide in open and closed societies.


Locus of control in negro and white children at four age levels.


Adipsic to polydipsic shift in gerbils induced by food deprivation.


Acquisition and extinction as a function of incentive shift.


Effects of chronic trifluoperazine administration in multiple dosages on rat offspring behavior.


Sex similarity in personality correlates of test anxiety.


Fear of death of those in a high stress occupation.


Sex and affective determinants of lecture content retention.


The portly psychologist, or, on the perils of using a control group.


Desirability responses in the personality research form by a sample of alcoholics.


Rearing variations and Hebb-Wiliams maze performance.


Comments on Heap, Boblitt, Moore, and Hord's "behavior-milieu therapy with chronic neuropsychiatric patients".


A cultural delusion of alcoholics.

A cultural delusion of alcoholics.


Birth order and cooperativeness: peer ratings.


Therapeutic community for drug addicts, long-term measurement of emotional changes.


Voluntary inhibition of galvanic skin response.


Development and application of the KDS TM -1 in patient and outpatient settings.


Machiavellians and social mobility.

Machiavellians and social mobility.


Food deprivation, estrogen levels and self-stimulation in the female rat.


Food deprivation, estrogen levels and self-stimulation in the female rat: individual effects.


The Scottish Council for Post-graduate Medical Education.


Training the academic clinician.

Training the academic clinician.


The role of the universities in postgraduate medical education.


Vocational training for general practice and educational objectives.


Postgraduate training in laboratory medicine: biochemistry.


The Colleges and postgraduate medical education--a continuing and relevant role.


General professional training: a physician's viewpoint.


General professional training: a surgeon's viewpoint.


Surgical lesions of the adrenal gland.

Surgical lesions of the adrenal gland.


Acute fulminating osteomyelitis of the frontal bone.


The electroencephalographic recording of short- and long-term lithium effect.


Hand injuries: psychiatric considerations.


An evaluation of an ultrasound unit for continuous monitoring of the fetal heart.


Simultaneous electrophysical and biochemical monitoring of the fetus in labor.


Drug therapy of hypertension.

Drug therapy of hypertension.


A profile of the drug dependent patient.


A clinical review of congenital glaucoma.


Estriol excretion in cardiac disease during pregnancy.


Nocardial infection of the pulmonary and central nervous system: successful treatment with medical therapy.


Progressive electroencephalographic changes in laminar necrosis of the brain.


Extramedullary plasmacytomas of the head and neck.


Tissue penetrance of ampicillin.

Tissue penetrance of ampicillin.


Urine volume and prognosis in oliguric acute glomerulonephritis.


Electromyographic findings in high voltage electrical burns: two cases.


Cesarean section for fetal distress.

Cesarean section for fetal distress.


Atopic dermatitis.

Atopic dermatitis.


Hereditary osteo-onychodystrophy.

Hereditary osteo-onychodystrophy.


Pneumatosis intestinales.

Pneumatosis intestinales.


Hospital ketosis in the alcoholic diabetic: a syndrome due to isopropyl alcohol intoxication.


Tournique difficulty during intravenous regional anesthesia.


The year of pathology 1971-1972.

The year of pathology 1971-1972.


Role of the adrenal in the preferential accumulation of progestin by mesencephalic structures.


Heterocyclic corticosteroids. I. Biological properties of the 6,16 -dimethyl-4,6-pregnadiene-11 ,17,21-triol-20-one(3,2c)-2'-phenylpyrazole-21-acetate and its 21-desoxy derivative.


Steroids in newborns and infants identification by combined gas chromatography-mass spectrometry of the major steroids excreted by a newborn chimpanzee (Pan troglodytes).


Chromatographic mobilities and partition coefficients of synthetic corticosteroid glucosiduronates.


Estimation of total estrogens in early pregnancy by column chromatography.


Preparation of 9-alpha,11-xi-tritiated 17-alpha-ethynylestradiol, mestranol, estradiol-alpha-17-beta, and norethindrone. The preparation of 9alpha, 11xi-tritiated 17alpha-ethinyl estradiol, mestranol, estradiol-17beta, and norethindrone are described.  Estrone-3-methyl ether was employed as starting material, and ethinylation with lithium acetylide-ethylene diamine resulted in 95% mestranol.  Demethylation of mestranol with boron tribromide at 0 degrees resulted in 92% 17alpha-ethinyl estradiol.  Dimethylsulfoxide was the choice of reagent for the condensation reaction which was complete at room temperature in about 4 hours.  The usually less than 3% of unreacted 17-oxo product was removed by Girard separation.  Demethylation of methyl ether with boran tribromide in methylene chloride resulted in an excellent yield of 17alpha-ethinyl estradiol-9alpha, 11xi-tritium.  3-methoxyestra-1,3,5-trien-17-one-9alpha, 11xi-tritium was reduced with sodium bis(2-methoxyethoxy) aluminum hydride to the 17beta-hydroxy compound and subsequent demethylation resulted in estradiol-9alpha, 11xi-tritium.  The general method of Ringold et al was employed for the preparation of 17beta-hydroxy-17alpha-ethinylestr-4-en-3-one.  Improvements for small scale radiosynthesis are also presented.


Glycogen deposits in motorneurones of young chickens following peripheral nerve section.


Uptake of exogenous proteins in mouse olfactory cells.


Neurotoxicity of tricresylphosphate (TCP) in slow loris (Nycticebus coucang coucang).


Chromosomal characteristics of human pituitary adenomas.


Arterial carbon dioxide tension in bronchial asthma.


Are nasal polyps an allergic phenomenon?


Frequency of reactions to alum precipitated ragweed extract.


Clinical allergy and general medicine.

Clinical allergy and general medicine.


Comparative study of the intracutaneous, scratch and prick tests in allergy.


Basal cell naevus syndrome.

Basal cell naevus syndrome.


Characterization of phycoerythrin from a Cryptomonas sp.


The cell wall as the site of carotenoid in the "Knallgas" bacterium, 12-60-x.


Carotenoid composition in the genus Ectothiorhodospira pelsh.


Extent of the visual field. Changes with age and oxygen tension.


A re-examination of Desulfovibrio africanus.


Corneal cysts. A report of eight cases.

Corneal cysts. A report of eight cases.


A new method of cryoextraction.

A new method of cryoextraction.


Adhesion between retina and pigment epithelium. Measurement by peeling.


Corneal glucose flux. II. Its response to anterior chamber blockade and endothelial damage.


An attempt at a chemical treatment of myopia.


Silicone sponges.

Silicone sponges.


Pheromone trail-following studies of typhlopid, leptotyphlopid, and colubrid snakes.


Human plasma high-density lipoproteins: past, present and future.


Individual recognition by voice in reindeer mother-young relationship. Field observations and playback experiments.


Biosynthesis of plasma lipoproteins.

Biosynthesis of plasma lipoproteins.


Turnover of plasma lipoprotein cholesterol.


Enzyme insolubilization with cross-linked polyacryloylaminoacetaldehyde dimethylacetal.


Heterotropic co-operative effects between amino acid substrates of phenylalanine hydroxylase.


An altered erythrocyte acetylcholinesterase associated with hereditary muscular dystrophy in mice.


Identification in urine of a low-molecular-weight highly polar glycopeptide containing cysteinyl-galactose.


A sensitive method for the detection of metabolites of dianabol in urine in man.


The metabolism of methamphetamine in the rat and guinea pig.


The effect of linoleic acid, peroxidation and antioxidants on induction of cytochrome P-450 in rat liver.


The preparation and culture of spontaneously fused tobacco leaf spongy-mesophyll protoplasts.


Isolation of dense bodies containing acid hydrolases and iron from rat spleen.


Studies on olfactory receptor mechanisms.


Oestradiol-17  stimulation of ribonucleic acid synthesis in immature rat uterus: the effects of injection route and rat weight.


Separation of ribonucleic acid from immature rat uterus on polyacrylamide gels and the effect of oestradiol-17 .


Studies on the methylated regions of HeLa-cell ribosomal and nucleolar ribonucleic acids.


Effects of amino acid starvation on ribosome formation in HeLa cells.


Methylation of newly synthesized ribonucleic acid by isolated rat liver nuclei: a means of characterizing ribonucleic acid synthesized in vitro.


Alkylated components in rat liver ribonucleic acid: a possible index of true biological turnover.


An immuno-electrophoretic assay of beta-lipoprotein and albumin in human aortic intima by direct electrophoresis from the tissue sample into an antibody-containing gel.


The action of fructose on ethanol metabolism by intact isolated liver cells.


Effect of a high-ethanol and choline-deficient diet on the metabolism of ( 3 H)oestradiol in vitro by subcellular fractions of male rat livers.


Comparative studies on rat mast-cell-granule protease and a bovine liver-capsule protease.


Metabolism in vitro of (4- 14 C)4-androstene-3,17-dione by livers from normal and carbon tetrachloride-poisoned rats.


An intact muscle preparation suitable for studies of the metabolic effects of electrical stimulation.


Evidence for the presence of a pool of glycerides with a rapid rate of turnover in brown fat from newborn rabbits. 1. The specific radioactivity of [(14)C]glycerol released during the incubation of brown fat with [(14)C]glucose is much greater than that of the tissue lipid glycerol. 2. From a study of the release of [(14)C]glycerol from pre-labelled brown fat, it is concluded that the tissue contains a pool of glycerides with a higher rate of turnover than those in the main lipid store. 3. This pool contains newly synthesized glycerides, has a half-life of 25-30min and supplies about 25% of the glycerol liberated by brown fat. 4. Thus, a significant fraction of the total (14)C incorporated from glucose into brown-fat lipids is released as [(14)C]glycerol during an incubation.


The lysosomal membrane complex. Focal point of primary steroid hormone action. At short intervals after the intravenous administration of oestradiol-17beta, diethylstilboestrol, testosterone or saline control solution to ovariectomized rats, highly purified lysosome samples were prepared in substantial yield from preputial glands, sex accessory organs rich in these organelles. The preparations were essentially devoid of mitochondrial contamination. Exposure in vivo to doses of these hormones varying from 0.1 to 5mug/100g body wt. provoked dose-dependent labilization of the lysosomal membrane surface, as evidenced by significantly diminished structural latency of several characteristic acid hydrolases, including acid phosphatase, beta-glucuronidase and acid ribonuclease II, when such preparations were subsequently challenged in vitro with autolytic conditions, detergent or mechanical stress. Enhanced lytic susceptibility induced by hormone pretreatment was occasionally detectable in the initial preparation without further provocative stimuli in vitro. Comparable results were obtained with the corresponding fractions of uterus, despite the more limited concentration of lysosomes in this steroidal target organ. By the present criteria oestradiol-17alpha was essentially inert, even in a dose 25 times that effective for its active beta-epimer (<0.1mug/100g body wt.). Pretreatment with diethylstilboestrol exerted substantial membrane-destabilizing influence in preputial-gland lysosome samples from orchidectomized rats. Moreover, administration of testosterone to gonadectomized animals resulted in essentially equivalent dose-dependent augmentation of lysosomal enzyme release in preputial-gland preparations of either sex. The membrane stability of lysosome-enriched preparations from uterus, on the other hand, was unaffected by testosterone pretreatment. The sensitivity, specificity and selectivity of the lysosomal response to sex steroids provide evidence for the physiological significance of this phenomenon as a general mechanism for mediation of secondary biochemical transformations in the hormone-stimulated target cell.


Changes in the transcription pattern of flax cotyledons after inoculation with flax rust. The rate of (32)P incorporation into RNA fractions of flax cotyledons (Linum usitatissimum L. var. Bison) was found to increase two- to three-fold by 48h after inoculation with flax rust [Melampsora lini (Pers.) Lev., race no. 3]. This was accompanied by a change in the nucleotide composition of the newly transcribed sodium chloride-soluble RNA fraction. A comparison of the nucleotide composition of the RNA synthesized in the host-parasite complex at different stages of development indicated the preferential synthesis of one or more molecular species of RNA with a high A+U/G+C ratio at a relatively early stage of infection. Treatment of healthy plants with indol-3-ylacetic acid also resulted in a substantial stimulation in the rate of (32)P incorporation into RNA but this was not accompanied by a detectable change in the nucleotide ratios of the newly synthesized RNA. These results suggest that the synthesis of one of more additional RNA species or the augmented synthesis of certain species of RNA may be a specific phenomenon elicited by host-pathogen interaction.


A role for phospholipids in the binding and metabolism of drugs by hepatic microsomes. Use of the fluorescent hydrophobic probe 1-anilinonaphthalene-8-sulphonate. 1. The pretreatment of rat liver microsomes with phospholipase C or D decreased the N-demethylation of (+)-benzphetamine. The hydroxylation of aniline was essentially unchanged by pretreatment of microsomes with phospholipase C. 2. Some components of the microsomal mixed-function oxidase system were impaired by phospholipases. 3. The fluorescence of 1-anilinonaphthalene-8-sulphonate (ANS) was greatly enhanced by microsomes. Phospholipase C or D markedly decreased ANS-microsome fluorescence. Quantum yield of ANS-microsome fluorescence appeared to be related directly to phospholipid content of microsomes. 4. Most of the drugs studied enhanced ANS-microsome fluorescence. Warfarin, however, displaced ANS fluorescence competitively from microsomes. The latter effect was postulated as being due to warfarin competing with ANS for the cationic site on microsomal phosphatidylcholine. 5. ANS fluorescence was also increased by the presence of phospholipid micelles. The fluorescence of ANS-phosphatidylcholine micelles was modified by warfarin and (+)-benzphetamine in a manner similar to that observed with microsomes. Warfarin decrease of fluorescence was absent when ANS was bound to phosphatidic acid, which lacks a cationic site. 6. Trypsin pretreatment of microsomes did not modify ANS-microsome fluorescence, including drug-induced changes. 7. It was postulated that phospholipids have a permissive role in the metabolism of most drugs by hepatic microsomes and that the ANS probe might reflect interactions of compounds with microsomal membrane phospholipids.


Characterization of a neutral protease from lysosomes of rabbit polymorphonuclear leucocytes. 1. The subcellular distribution has been investigated of a protease from rabbit polymorphonuclear leucocytes, obtained from peritoneal exudates. The enzyme, optimally active between pH7.0 and 7.5, hydrolyses histone but not haemoglobin, sediments almost exclusively with a granule fraction rich in other lysosomal enzymes, and is latent until the granules are disrupted by various means. 2. Enzymic analysis of specific and azurophilic granules separated by zonal centrifugation showed that neutral protease activity was confined to fractions rich in enzymes characteristic of azurophile granules. 3. Recovery of neutral protease activity from subcellular fractions was several times greater than that found in whole cells. This finding was explained by the presence of a potent inhibitor of the enzyme activity in the cytoplasm. 4. The effect of the inhibitor was reversed by increasing ionic strength (up to 2.5m-potassium chloride) and by polyanions such as heparin and dextran sulphate, but not by an uncharged polymer, dextran. 5. The enzyme was also inhibited, to a lesser extent, by 1-chloro-4-phenyl-3-l-toluene-p-sulphonamidobutan-2-one, soya-bean trypsin inhibitor and in-aminohexanoate (in-aminocaproate). 6. The granule fractions failed to hydrolyse artificial substrates for trypsin and chymotrypsin. 7. Partial separation of the enzyme was achieved by Sephadex gel filtration at high ionic strength and by isoelectric focusing. The partially separated, activated enzyme showed an approximately 300-fold increase in specific activity over that in whole cells.


The transport of citrate and other tricarboxylic acids in two species of Pseudomonas. When cells of Pseudomonas are grown on citrate as the sole carbon source they oxidize citrate and isocitrate rapidly. Fluorocitrate inhibits the oxidation of citrate. Fluorocitrate-treated cells accumulate [6-(14)C]citrate, as shown by a rapid Millipore-filtration technique. In the absence of fluorocitrate most of the [6-(14)C]-citrate is lost in the form of (14)CO(2). The isolation of a pseudomonad characterized by its ability to grow on tricarballylate as a sole carbon source has facilitated the study of the tricarboxylate-carrier specificity. Cells grown on citrate will exchange radioactive citrate for unlabelled citrate or isocitrate but not for cis-aconitate, trans-aconitate or tricarballylate. Cells grown on tricarballylate will exchange radioactive citrate for unlabelled citrate, cis-aconitate or tricarballylate, but not for isocitrate or trans-aconitate. The properties of the exchange system involved are compared with those of the related system in mitochondria.


The hydrolysis of glycosyl fluorides by glycosidases. Determination of the anomeric configuration of the products of glycosidase action. The enzymic hydrolysis of glycosyl fluorides is conveniently followed by using a pH-stat. Reactions involving glucosyl or galactosyl fluorides can also be followed by using glucose oxidase or galactose oxidase respectively. The pH-stat allows the rapid assay of intestinal alpha-glucosidase in crude homogenates. Use of glycosyl fluorides as substrates for glycosidases facilitates the polarimetric or g.l.c. determination of the anomeric nature of the initial product of hydrolysis. Hydrolysis by fungal amyloglucosidase proceeds with inversion of configuration whereas that by yeast and rat intestinal alpha-glucosidase, coffee-bean alpha-galactosidase and almond emulsin beta-glucosidase proceeds with retention of configuration. beta-d-Glucopyranosyl azide was not a detectable substrate for almond emulsin beta-d-glucosidase.


The amino acid sequence around four cysteine residues in trout actin. Four unique carboxymethylcysteine-containing peptides were isolated from tryptic and chymotryptic digests of trout muscle actin carboxymethylated with iodo[2-(14)C]acetic acid in 6m-guanidinium chloride. The amino acid sequences of these peptides were determined and showed a high degree of homology with the corresponding sequences from rabbit actin. One of the radioactive peptides was the C-terminal peptide and another sequence probably contained the cysteine residue from the N-terminal region of the protein.


Assembly of immunoglobulin M. Blocked thiol groups of intracellular 7S subunits. We have shown previously that immunoglobulin M (IgM) is present within IgM-forming cells mainly in its 7S subunit form (IgMs), whereas only fully assembled IgM pentamers are secreted. There is no spontaneous polymerization of intracellular IgMs in cell lysates, suggesting that the 7S subunits had blocked cysteine residues. This suggestion was explored and confirmed in the present paper. Radioactive IgM (secreted) and IgMs (intracellular) were prepared by sucrose-density-gradient centrifugation after incubation of cells of the IgM-producing mouse myeloma MOPC 104E with [(3)H]leucine. We investigated the susceptibility to reduction of fully assembled mouse IgM and its reconstitution from subunits by analysis by polyacrylamide-gel electrophoresis under dissociating conditions. With increasing concentrations of dithioerythritol, interchain disulphide bonds were cleaved in the following order: inter-IgMs subunit, intra-IgMs subunit H-H, intra-IgMs subunit H-L. Removal of the reducing agent from IgM-reduction mixtures by filtration through Sephadex G-25 caused partial reconstitution of IgM at low protein concentrations (5-100mug/ml) and total reconstitution at higher protein concentrations (300mug/ml or more). Isolated radioactive intracellular IgMs showed no tendency to polymerize unless first treated with a reducing agent; under optimum conditions removal of the reducing agent caused 70% of the subunits to be assembled into IgM. Similar assembly occurred when IgMs was isolated from cells that had been lysed in the presence of an irreversible alkylating reagent (iodoacetamide). The intracellular IgMs cysteine residues responsible for inter-IgMs linkage therefore appear to be reversibly blocked within the cells. Assembly into IgM is thus controlled by removal of this block during secretion.


Biosynthesis of rat serum albumin.

Biosynthesis of rat serum albumin. 1. The labelling of intracellular and extracellular serum albumin was studied in liver slices and in whole rats by using new methods for the purification of the protein. 2. The results suggest that a polypeptide precursor is formed that is converted relatively slowly into serum albumin. 3. The effect of liver cell K(+) has been examined by a double-label method and it is shown that K(+) accelerates the rate of conversion of ;precursor' into albumin. The rate of transit of albumin across the cell membrane appears to be unrelated to the concentration of K(+) within the cell. 4. The time-course of incorporation of radioactive amino acid into albumin follows a sigmoidal mode. There is a pronounced time-lag before label starts to appear in intracellular albumin, and a further time-lag before it appears in extracellular albumin. 5. In slices the sum of intra- and extra-cellular label rises steadily from 30min after the start of labelling with a pulse of labelled leucine or valine and continues to rise for at least another 60min. This occurs whether labelling is stopped by addition of excess of carrier amino acid or with cycloheximide (100mum) or both. 6. The intracellular albumin content remains constant whether slices are maintained with low or normal intracellular K(+) concentrations. 7. Specific radioactivities of intracellular albumin (and fractions thereof) and of extracellular albumin were determined in vitro and in vivo. The results show that the intracellular albumin cannot be a precursor of extracellular albumin, unless a very small compartment is turning over much more rapidly than the bulk of the liver albumin or even of the microsomal albumin.


Immunoglobulin M biosynthesis. Production of intermediates and excess of light-chain in mouse myeloma MOPC 104E. Immunoglobulin M (IgM) biosynthesis was studied with mouse plasma-cell tumour MOPC 104E as a model system. Cell suspensions prepared from solid tumours were incubated in vitro with [(3)H]leucine; the radioactivity incorporated into intracellular and secreted proteins was analysed by sucrose-density-gradient centrifugation and polyacrylamide-gel electrophoresis. The tumour secretes IgM and light chains. ;Pulse-chase' experiments indicated average secretion times of 1.5h for light chain and 2.5h for IgM. The order of disulphide-bond assembly within the cell was shown to be heavy chain+light chain --> heavy chain-light chain intermediate --> IgMs. The 7S subunit (IgMs) was polymerized into IgM just before or at the time of secretion. Measurements of heavy-chain/light-chain radioactivity ratios in intracellular HL and IgMs and secreted IgM demonstrated the existence of a light-chain pool participating in IgM biosynthesis. The size of the light-chain pool, together with analysis of clones isolated in vivo, suggested that the tumour contains cells in which light-chain synthesis is in excess of heavy-chain production.


Optical rotatory dispersion and circular dichroism of superhelical deoxyribonucleic acid.


Studies on the metabolism of vitamin A: the effect of vitamin A status on the content of some steroids in the ovaries of pregnant rats.


Sterol biosynthesis in the starfish Asterias rubens and Henricia sanguinolenta.


Ribonucleic acid polymerase activity in cardiomyopathic hamster heart nuclei.


Properties of mouse globin messenger ribonucleic acid and its preparation in milligram quantities.


Isolation and characterization of the cyanogen bromide peptides from the  l(II) chain of chick cartilage collagen.


Amino- and carboxyl-terminal amino acid sequences of the Peptostreptococcus eisdenii and Clostridium pasteurianum flavodoxins.


Synthesis of polypeptides and oligopeptides with the repeating sequence L-alanyl-L-prolylglycine.


Conformational investigations on the polypeptide and oligopeptides with the repeating sequence L-alanyl-L-prolylglycine.


Studies on the conformational isomers of deoxycytidylate aminohydrolase.


Properties of graphical representations of multiple classes of binding sites.


Mechanism of mammalian cobalamin-dependent methionine biosynthesis.


Gel electrophoresis of mucous glycoproteins. II. Effect of physical deaggregation and disulfide-bond cleavage.


Partial amino acid sequences of chicken and turkey immunoglobulin light chains. Homology with mammalian lambda chains.


Sequence of a segment of muscle glycogen phosphorylase containing the pyridoxal 5'-phosphate binding site.


Proportion of keto and aldehydo forms in solutions of sugars and sugar phosphates.


Equilibrium casein micelle systems.

Equilibrium casein micelle systems.


Preferential uptake of D-glucose by isolated human erythrocyte membranes.


Complexes of phosvitin with poly-L-lysine and protamine. Conformational analysis.


Microdetermination of nucleic acid phosphorus by neutron activation analysis.


Inhibition of synthesis of new globin chains in reticulocyte lysates by pactamycin.


Isolation of mouse satellite deoxyribonucleic acid by composite polyacrylamide gel electrophoresis.


Question of the ribosyl moiety in the promotion of callus growth by exogenously added cytokinins.


Specificity and mechanism of clostripain catalysis.


Photochemistry of uracil and uridine.

Photochemistry of uracil and uridine.


Baker's yeast cytosine deaminase. Some enzymic properties and allosteric inhibition by nucleosides and nucleotides.


Intracellular site of proline hydroxylation in plant cells.


Biosynthesis of dimethylarsine by Methanobacterium.


Corn and potato  -1,4-glucan: -1,4-glucan 6-glycosyltransferase: evidence for separate hydrolytic and branching components.


Reaction of 7-bromomethylbenz(a)anthracene with nucleic acids, polynucleotides, and nucleosides.


A homologous series of affinity labeling reagents and their use in the study of antibody binding sites.


Resolution of some component classes of complex RNA by molecular hybridization in the eukaryote Tetrahymena pyriformis.


Control of protein synthesis during the activation of lymphocytes by phytohaemagglutinin.


Control of the increased protein synthesis in kidney of nephrotic rats by supernatant factors.


Histone synthesis and phosphorylation in regenerating rat liver.


B.C.G. by jet injection.

B.C.G. by jet injection.


Effects of oestradiol,  -amanitin and ionic strength on the in vitro synthesis of RNA by uterus nuclei.


Typhoid carriers.

Typhoid carriers.


Future of British psychiatrists.

Future of British psychiatrists.


Taste and smell.

Taste and smell.


Coagulation defects in hypoxic full-term newborn infants. Blood clotting was examined in 24 consecutive full-term newborn infants with hypoxia and 23 normal control infants. There was evidence of a gross alteration in the clotting process in the hypoxic infants. The degree of disturbance in clotting seemed to be dependent on the severity of the hypoxia, suggesting a causal relationship. The mechanism involved seemed to be intravascular coagulation. The consumption of clotting factors involved led to the appearance of a haemorrhagic diathesis. This effect seemed to be of short duration, suggesting that direct liver damage plays at most a minor part.Though there was no evidence of damage in the infants who survived, it is possible that intravascular coagulation induced by hypoxia, by leading to deposition of fibrin, may cause damage to vital organs. Further studies will be required to examine this possibility.


Factors influencing return to work.

Factors influencing return to work.


Intraepithelial carcinoma of the cervix uteri in women aged under 35 years. The number of cases of intraepithelial carcinoma of the cervix among women of different age groups has been related to the number of cervical smears from women of the same age groups. Among women aged 25 to 34 years the incidence of intraepithelial carcinoma was 0.67% and among those aged 35 to 44 years it was 0.75%. The overall rate of intraepithelial carcinoma in women under 35 years was 0.55% compared with an overall rate of 0.59% in women over 35 years.If screening of women for cervical cancer is to play any part in preventive medicine it is suggested that the national campaign for the early detection of cervical cancer should be expanded to encourage practitioners to take cervical smears from younger women, particularly from those under 35 years.


Sclerosant injection for varicose veins.


Pupillary mobility and skin colour.

Pupillary mobility and skin colour.


Crystals in skeletal muscle.

Crystals in skeletal muscle.


Hypoglycaemia in infancy and childhood.

Hypoglycaemia in infancy and childhood.


Cot deaths and deficiency of vitamin E and selenium.


Specimens from the female genital tract.


Diagnosis of appendicitis.

Diagnosis of appendicitis.


The lung in ankylosing spondylitis.

The lung in ankylosing spondylitis.


Anticoagulant interactions.

Anticoagulant interactions.


Hamster-hair hypersensitivity.

Hamster-hair hypersensitivity.


Incorporation of tritiated thymidine into the skin and hair follicles. II. Daily fluctuations in  3 H-TdR and  3 H-UR levels.


Effects of hydroxyurea on the kinetics of colony forming units of bone marrow in the mouse.


Observations on the effect of therapy with nitrogen mustard or a derivative on chromosomes of human peripheral blood lymphocytes.


DNA synthesis time in leukaemic cells as measured by the double labelling and the percentage labelled mitoses methods.


The determination of urinary phenylacetylglutamine as phenylacetic acid. Studies on its origin in normal subjects and children with cystic fibrosis.


Serum creatine kinase and adenylate kinase in thyroid disease.


A rapid method for the detection of methaqualone metabolites.


The rapid determination of acetone in breath and plasma.


Clinical and experimental studies of acid phosphatase in renal failure.


A fluorometric method for the determination of plasma tyrosine concentrations.


A simple automated method for the measurement of oestrogens in the urine of pregnant women.


Serum enzyme studies in inherited disease of skeletal muscle.


Serum enzyme studies in acquired disease of skeletal muscle.


Tyrosine metabolism: urinary excretion studies in Parkinsonism.


Glycoproteins in human bile.

Glycoproteins in human bile.


Action limits for internal quality control.


Gas-liquid-chromatographic determination of bile acids in bile.


Whole blood samples dried and stored on filter paper as substrate for the electrophoretic separation on hemoglobin S from hemoglobin A. A screening procedure.


Colorimetric assay for  -glutamyl transpeptidase.


The excretion of imidazoles following histidine loading in cases of thyrotoxicosis.


Effects of light on the determination of citrulline.


Calcium-binding method revisited.

Calcium-binding method revisited.


L-dopa and S-adenosylmethionine.

L-dopa and S-adenosylmethionine.


The quantitative estimation of urinary  3 -methoxy- 4 -hydroxy phenylacetic acid (homovanillic acid).


Isoelectric focusing of alkaline phosphatases. A focusing-disc electrophoresis transfer technique.


A study of calcium absorption using an automated fluorimetric assay procedure.


A routine method for the detection and quantitation of amphetamine in urine.


A new color reaction for cholesterol assay.


Does chlorpromazine interfere with the Porter-Silber reaction?


Determination of serum iron and latent iron-binding capacity (LIBC).


A method for the determination of urinary metabolites of tryptophan.


-L-fucosidase and other glycosidases in human placenta, foetus liver and amniotic fluid at various stages of gestation.


Chromosomal polymorphism in Peromyscus polionotus.


Sex-chromatin formation in pre-implantation rabbit embryos.


Observations on the incidence of Robertsonian translocations and associated testicular changes in a flock of New Zealand Romney sheep.


Comparison of chromosomal behavior in cultured lymphocytes and fibroblasts from patients with chromosomal disorders and controls.


Observations on human somatic chromosomes treated with hyaluronidase.


Meiotic studies on a subfertile patient with a ring Y chromosome.


Genetics of the immune response. II. Paralysis by phage fd in high and low responding inbred strains of mice.


Early changes in the phospholipid metabolism of lymphocytes following stimulation with phytohemagglutinin and with lysolecithin.


Composite remedies for psychosocial problems.


Optimal treatment for patients of all races and social classes in a Los Angeles clinic.


Crisis in chronic problem families.

Crisis in chronic problem families.


Psychiatric care of the underprivileged.


Cramer's splint.

Cramer's splint.


Thalamic tumour. A case report.

Thalamic tumour. A case report.


Atrial tachycardia with block without digitalis toxicity successfully treated with digoxin.


Selective renal arteriography.

Selective renal arteriography.


Diagnostic value of renal angiography.

Diagnostic value of renal angiography.


Cholera has to be fought on a national scale.


Is oxygen always safe?

Is oxygen always safe?


Personality traits and coronary heart disease.


Experimental osteomyelitis. II. Therapeutic trials and measurement of antibiotic levels in bone.


Resistance to murine tumors conferred by chronic infection with intracellular protozoa, Toxoplasma gondii and Besnoitia jellisoni.


Random distribution of schistosome eggs in the feces of patients with Schistosomiasis mansoni.


Current status of measles in the United states.


Selected pharmacological studies of an alkaloidal extract of Banisteriopsis quitensis.


Methotrexate pharmacokinetics.

Methotrexate pharmacokinetics.


Short-living radioisotopes ( 99m Tc,  113m In) as a label for erythrocytes: labeling problems and utilisation in spleen studies.


Stability of tecomine, the major antidiabetic factor of Tecoma stans (Juss.) f. bignoniaceae.


Segmental, sequential and quantitative pulmonary investigations using the scintillation camera.


Automatic analysis of cerebral blood flow.


Clinicopathologic effects of chronic reserpine administration in mongrel dogs.


Kinetics of hydrolysis of barbituric acid derivatives.


Dissociation constants of sparingly soluble substances: nonlogarithmic linear titration curves.


Evaluation of the parameters of a compartmental system for the study of the kinetics of plasma glucose and insulin in normal, diabetic, and obese subjects.


Changes in  133 Xe clearances resulting from electrically induced muscle contractions. II. Study in man.


Short-lived isotopes in brain scanning. Experience with 1774 patients.


The regional distribution of pulmonary blood flow as determined by lung scintigraphy in cardiac patients.


Toxicity of ethylene chlorohydrin. II. Subacute toxicity and special tests.


Measurement of blood flow in skeletal muscle with chelated ytterbium-169 and electrical stimulation.


Relative substituent effects on alkaline solvolysis of  -lactams (2-azetidinones) and amides.


Significance of vehicle composition. I. Relationship between topical vehicle composition, skin penetrability, and clinical efficacy.


Significance of vehicle composition. II. Prediction of optimal vehicle composition.


Enzyme inhibitors. 23. Syntheses of 9-(substituted aralkyl)-6-substituted purines as inhibitors of adenosine deaminase.


Substituted aralkyl aldehydes: preparation and antitumor evaluation.


Rheological and sensory evaluation of work softening and recovery of pharmaceutical white soft paraffins.


Degradation of urea in concentrated aqueous solution.


Combined GLC and high-resolution mass spectroscopic analysis of diphenylhydantoin.


Analysis of NMR spectra for rotamer populations of dimethoxyamphetamines.


Unexpected formation of thioacridone and its spectral properties.


Pharmacological evaluation of 3,4-dimethoxyphenylacetamide.


Structure and activity in molluscicides. 3. Enzymatic peroxidation of the molluscicidal agent pentachlorophenol.


Mississippi-grown Cannabis sativa L: preliminary observation on chemical definition of phenotype and variations in tetrahydrocannabinol content versus age, sex, and plant part.


Analgesics: synthesis of 1-dioxolanoalkylnormeperidines and 1-dioxanoalkylnormeperidines.


Aromatic amines condensed with aminothiazoles, directly and with isatoic anhydride, for schistosomiasis treatment I.


Tumor inhibitors. II. Cytotoxic alkaloids from Annona purpurea.


Color reaction of thyroxine and its derivatives with nitrous acid.


Phenothiazines as anticholinergics.

Phenothiazines as anticholinergics.


Detection of CL-912, a 1,3-dioxalane, in collapsible tube liner by attenuated total reflection spectroscopy.


New compounds: preparation of oxime esters from 1-azabicyclo(4.4.0)decane-4-one.


NMR evidence for self-association of theophylline in aqueous solution.


NMR evidence for self-association of teophylline in aqueous solution: a response.


Interference in GLC determination of iodoamino acids in hydrolysis products of thyroid extracts.


Assay of warfarin.

Assay of warfarin.


Assay of warfarin: a rebuttal.

Assay of warfarin: a rebuttal.


Possible reaction pathway for acylation of coenzyme A.


Correction for effect of dilution on diffusion through a membrane.


A scanning electron microscopic study of synovial joints.


Decreased chemoreceptor sensitivity and chronic obstructive lung disease.


Hypertension and depression: interrelated problems in therapy.


Mechanisms involved in cell-mediated immunity.


Exercise in the treatment of coronary artery disease.


Liver parenchymal and Kupffer cell metabolism of  14 C-labeled acetate, palmitate, and triglyceride.


Quantitation and determination of sensitivity of radial hemolysis in gel (RHG).


The suppression of antigen-stimulated human lymphocytes by exogenous RNA.


Infection caused by Mycobacterium fortuitum.


A glimpse of upper echelon Soviet medicine.


Effect of cyclophosphamide upon the immune response in Wegener's granulomatosis.


IgG, beta 1 C, fibrinogen cryoprotein in acute glomerulonephritis.


Functional aortic insufficiency. A feature of renal failure.


Challenges for change.

Challenges for change.


Frequency of negative intermediate-strength tuberculin sensitivity in patients with active tuberculosis.


Accumulative prognostic index for patients with barbiturate, glutethimide and meprobamate intoxication.


Prognosis by calculation.

Prognosis by calculation.


Prostaglandins as abortifacients.

Prostaglandins as abortifacients. Clinical trials have demonstrated the use of prostaglandins as effective abortifacients.  Continuous intravenous infusion of the drugs however has been associated with certain side effects at therapeutically effective doses, such as nausea, vomiting, diarrhea and a local erythematous reaction at the site of venepuncture.  Higher doses result in more serious side effects such as vasovagal symptoms, pyrexia and tachycardia.  Direct application of prostaglandins E2 or F2a into the uterine cavity has been shown to minimize the side effects.  Appropriate doses of prostaglandins every one or 2 hours administered at the site of action between the fetal membrane and uterine wall (via the cervix) produce the strong and frequent uterine contractions necessary for the expulsion of the products of conception.  A drawback of this method is the need for the uterine cavity to be continuously monitored as dosage is determined by the uterine response.  Another effective method of terminating 1st and 2nd trimester pregnacy with minimal side effects is vaginal administration (into the posterior fornix) of 50 mg PGF2a or 20 mg PGE2 every 2 or 3 hours.  Single injection of prostaglandins into the amniotic sac usually results in complete abortion.  The method is simple but should be used only in pregnancies of over 12 weeks' gestation as the amniotic sac is inaccessible in the 1st trimester.  The prostaglandin method, compared with other methods of abortion in the 1st trimester of pregnancy (e.g., suction or dilatation and curettage) is inferior in terms of time, expense and convenience.  Incomplete abortion is quite common in the 1st trimester when prostaglandins are used.  With respect to 2nd trimester methods (hypertonic saline and hysterotomy) however, prostaglandins given by intravaginal, intrauterine, or intraamniotic routes offer clear advantages.


Western medicine in tropical lands.

Western medicine in tropical lands.


The abnormal lipoprotein of cholestasis.


Tonsillectomy and adenoidectomy in Massachusetts.


Implications of bacteriuria.

Implications of bacteriuria.


Mesenteric angiography.

Mesenteric angiography.


Iatrogenic post-exercise cerebral ischemia.


Digitalis toxicity and serum levels.

Digitalis toxicity and serum levels.


For direct words on abortion.

For direct words on abortion.


Hemoglobin, packed cell volume, serum iron and iron binding capacity of selected athletes during training.


The influence of dietary sunflowerseed oil and hardened coconut oil on intra-arterial occlusive thrombosis in rats.


Serum glucose and fructose levels after sucrose meals in atherosclerosis.


Lecithin: cholesterol acyltransferase activity in the plasma of rats fed sucrose or starch.


Single cell protein in clinical testing. A tolerance test in healthy adult subjects comprising biochemical, clinical and dietary evaluation.


Risks of long-term ascorbic acid overdosage.


Biological quality of a lipoprotein concentrate from sunflower seed (Helianthus annuus L.).


Pica and lead poisoning.

Pica and lead poisoning.


Acquired myopia in young pilots.

Acquired myopia in young pilots.


Combined panel D-15 and 100 Hue recording.


Effect of ophthalmic artery perfusion pressure on ocular rigidity.


Pupil-block. Its mechanism and prevention. I. The significance of mid-dilation of the pupil. A theoretical consideration.


Pupil-block. Its mechanism and prevention. II. Dilating the pupil by a mydriaticum-ismelin combination. A procedure with minimal risk.


Morphologic evidence of centrifugal fibers in the retina.


Validity of Koppitz's developmental score as a measure of organicity.


Temporal orientation in suicidal patients.


Comparison of factor structures for the Frostig Developmental Test of Visual Perception.


Situational variability of preschoolers' disfluency: preliminary study.


Social desirability, the halo effect, and stereotypical perception in person perception and self-perception.


Neural fatigue and individual differences in latency and duration of autokinesis.


Movement responses and originality.

Movement responses and originality.


Effects of levels of motor activity on visual thresholds for activity-related words and pictographs.


Set, satiation, and confusion: a reply to Sadler and Mefferd.


Rationale and standardization for a combined speech articulation and auditory discrimination test.


"Functional" defective articulation: an oral sensory disturbance.


Note on GSRS as operants during sensory deprivation.


Relation between cardiac patterns and reading performance in second and fourth grade children.


Evanescence of sensory deprivation effects: a comment on Oleson and Zubek's "effect of one day of sensory deprivation".


Factors in social perception: seating position.


Electromyographic responses to affective visual stimulation.


Stimulus function in errorless simultaneous discrimination.


Personality correlates of accurate time perception.


Portable Rod-and-frame Test as a measure of cognitive style in kindergarten children.


Field independence and Stroop color-word performance.


Figural aftereffects in vision as a function of surround.


Speech-sound discrimination and tactile-kinesthetic discrimination in reference to speech production.


A cross-cultural item-analysis of Bender-Gestalt protocols administered to ghetto and suburban children.


Social anxiety model of alcoholism.

Social anxiety model of alcoholism.


Procedure for study of reality testing in schizophrenics.


Rehearsal and recoding of information from visual sensory-memory.


Influence of deafness on the structure of personality.


Learning mathematics by discovery: implications for a creative child.


Noise-induced arousal and breadth of attention.


Lateralizing significance of WISC verbal-performance discrepancies for older children with learning disabilities.


Tolerance for discomfort among impulsive adolescent boys.


Effect of stimulus order on verbal and nonverbal visual-auditory association.


Time perception as related to reading achievement.


A simple device for the measurement of visual angles.


Gestalt variables and feature measures as predictors of discrimination latency for polygon patterns.


Effect of room size on critical interpersonal distance.


The middleness concept in children.

The middleness concept in children.


A psychophysical approach to the study of individuals perceptions of Rorschach cards.


Eye fixations and latency in a simplified search situation.


Locus of control shift in administrators.


Lateral organization, perceived depth and title preference in pictures.


Perception of line in clothing.

Perception of line in clothing.


Data requirements for satiation theories: a rejoinder to Price.


The "street addict role": implications for treatment.


Abstinence as a role requirement in psychotherapy.


A further motive for psychotherapists: communicative intimacy.


A note on the making of a psychiatrist: the transition from resident to private practioner.


Complexities of the clinical psychiatric teaching institution.


The meaning of success in a person with a "success phobia".


Psychiatry and age-ism: proposals for action in the year of the White House Conference on Aging.


Pathophysiology and therapy of disseminated intravascular coagulation.


The carbinole acaricides: chlorobenzilate and chloropropylate.


Environmental factors in Croup syndrome.


Cultivation of Saccharomyces cerevisiae in continuous culture. I. Growth kinetics of a respiratory deficient yeast strain grown in continuous culture.


Temperature effects on solute accumulation by Candida utilis.


Separation and structural analysis of vinyl and isovinyl azobilirubin derivatives.


The deacetylation of N-arylacetamides in vitro.


The number of catalytic sites in acetylcholinesterase. By using two methods of titration, the number of active sites in acetylcholinesterase was determined. Either stepwise inhibition of the enzyme by an irreversible inhibitor, namely di-isopropyl phosphorofluoridate, or direct measurement of the concentration of active sites by titration with o-nitrophenyl dimethylcarbamate yielded an equivalent weight of approx. 130000 for an active site in acetylcholinesterase. This indicates two sites per molecule, since the native enzyme has a molecular weight of 260000.


The effects of salicylate on the activity of rat liver tryptophan pyrrolase in vitro and in vivo. 1. Salicylate, in concentrations of 0.05mm and above, inhibits the basal activity of tryptophan pyrrolase in homogenates of rat liver and the activity induced by cortisol but not that induced by tryptophan. The inhibition is abolished by adding haematin to the reaction mixtures. 2. The intraperitoneal injection of 400mg of sodium salicylate/kg in the rat causes a decrease in the tryptophan pyrrolase activity in the liver at 30min, the activity is restored to normal at 2h, increases to sixfold after 5h and returns to the basal value at 12h. The activation of the enzyme by salicylate is prevented by the administration of cycloheximide but not by pretreatment with actinomycin D. The effects of the combined injection of salicylate and cortisol are additive, whereas those of salicylate plus tryptophan are not. The injection of salicylate causes a progressive increase in the holo-/apo-enzyme ratio and an increased content of tryptophan in the liver over a period of 3h. 3. It is suggested that salicylate inhibits tryptophan pyrrolase activity in vitro and in vivo by interacting with iron protoporphyrins and causes a later enhancement of the enzyme activity in vivo by a mechanism involving the release of tryptophan from its binding sites on circulating albumin and on other proteins.


Aspects of the chemistry of vegetable starches.


The compartmentation of non-esterified and esterified cholesterol in the superovulated rat ovary. 1. The specific radioactivities of non-esterified and esterified cholesterol, progesterone and 20alpha-hydroxypregn-4-en-3-one were determined in slices of superovulated rat ovary after incubation with [1-(14)C]acetate in vitro for various times. The specific radioactivities of progesterone and 20alpha-hydroxypregn-4-en-3-one were equal, and (during the fourth hour of incubation) exceeded those of the non-esterified cholesterol and the esterified cholesterol by factors of 2.8 and 7.6 respectively. 2. After separation of homogenates of superovulated rat ovary slices previously incubated with [(14)C]acetate into subcellular fractions by differential centrifugation, the specific radioactivities of non-esterified cholesterol in the cytosol, mitochondria, lipid-containing storage granules and microsomal fraction were 1220, 1510, 1420 and 4020d.p.m./mumol respectively; the corresponding values for the specific radioactivity of the esterified cholesterol were 600, 700, 730 and 760d.p.m./mumol. The specific radioactivities of progesterone and 20alpha-hydroxypregn-4-en-3-one were equal in all fractions; the corresponding mean specific radioactivity of progesterone+20alpha-hydroxypregn-4-en-3-one was 6150d.p.m./mumol. 3. By using glutamate dehydrogenase and cytochrome (a+a(3)) as mitochondrial markers, the presence of cholesterol side-chain cleavage enzyme was demonstrated in microsomal fraction free of mitochondrial contamination. 4. The specific radioactivities of ovarian non-esterified and esterified cholesterol, progesterone and 20alpha-hydroxypregn-4-en-3-one were determined up to 8h after the intravenous injection of [4-(14)C]cholesterol into superovulated rats. At all times the specific radioactivities of progesterone and 20alpha-hydroxypregn-4-en-3-one were equal to the specific radioactivity of non-esterified cholesterol and exceeded, by up to 3.3-fold, that of the esterified cholesterol. 5. It is concluded that non-esterified cholesterol formed from [(14)C]acetate in the endoplasmic reticulum equilibrates slowly with non-esterified cholesterol in other subcellular fractions, and is preferentially converted into steroids. Such a mechanism presupposes the operation of a microsomal cholesterol side-chain cleavage enzyme using non-esterified cholesterol as its substrate. Unrelated evidence is presented in support of the existence of such an enzyme. The results are discussed in the light of other biochemical and electron-microscopic findings relating to the compartmentation of cholesterol in steroidogenic tissues.


Protease and ribonuclease activities in bovine pituitary lobes. 1. Acid and alkaline protease activities in bovine anterior and posterior pituitary lobes were reinvestigated by measurement of u.v. and Folin-Ciocalteu colour values of trichloroacetic acid-soluble digestion products of denatured haemoglobin. 2. Both lobes of the pituitary gland contain a cathepsin with a pH optimum at 3.8. 3. When release of u.v.-absorbing material was used as the assay there was also an optimum at pH8.3-9.7, but this proved to be due to the release of nucleosides from an endogenous substrate. 4. The presence of a ;cyclizing' ribonuclease active at alkaline pH on endogenous RNA was confirmed by the inhibitory effects of phosphate, arsenate and bentonite. The activity was unaffected by heat, EDTA or metal ions. The enzyme also acted on exogenous RNA. 5. A purified preparation of neurosecretory granules from fresh bovine posterior pituitary lobes was free from alkaline ribonuclease activity. Most of the activity present in the tissue was recovered in the supernatant plus microsomal material. 6. The distribution of RNA did not follow that of the alkaline ribonuclease.


Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine. 1. Administration of a large dose (500mg/kg body wt.) of (3)H-labelled l-ethionine to rats resulted in the incorporation of a small amount of radioactivity into the liver DNA. Considerable evidence that this radioactivity was not due to contamination of the isolated DNA with labelled protein, RNA, S-adenosyl-l-ethionine or l-ethionine was obtained. 2. After acidic hydrolysis of the DNA isolated from the livers of rats treated with labelled l-ethionine, virtually all of the radioactivity present in the DNA was found in a fraction with similar chromatographic properties to 7-ethylguanine. 3. Treatment of rats with comparable doses of l-methionine did not lead to the formation of 7-methylguanine in the liver DNA. 4. These results are discussed in relation to the induction of liver tumours by ethionine.


Some industrial aspects of the enzymic degradation of starch.


Metabolism of sodium oestrone ( 35 S)sulphate in the rat. Intraperitoneal, intravenous or oral administration of sodium oestrone [(35)S]-sulphate to male and female Medical Research Council hooded rats is followed by the rapid excretion of the bulk of the radioactivity in urine in the form of inorganic [(35)S]sulphate. Pre-treatment of rats with an antibiotic regimen does not affect the results except in the case of oral administration, when relatively large amounts of the dose are recovered as ester [(35)S]sulphate in faeces. Intravenous administration of the labelled ester to male and female rats with cannulae in bile duct and ureter gave results similar to those obtained with free-range animals. Only small amounts of radioactivity appeared in bile and this was mainly in the form of ester sulphate, including both oestrone [(35)S]sulphate and oestradiol-17beta 3[(35)S]-sulphate. Whole-body radioautography pinpointed the liver as the probable site of the desulphation of the sulphate ester and this was confirmed by liver and kidney perfusion experiments and by studies with rats in which kidney function had been eliminated by ligation of the renal pedicles.


The number and location of genes for 5S ribonucleic acid within the genome of Drosophila melanogaster. DNA was prepared from wild-type and two mutant stocks of Drosophila melanogaster that differed in their dosage of the nucleolar organizer region. The relative amounts of DNA from the nucleolar organizer region in these preparations of DNA were determined by hybridization with (3)H-labelled 28S rRNA. As expected, the amount of (3)H-labelled 28S rRNA that hybridized was directly related to the dosage of nucleolar organizer region. No positive correlation was observed between the amount of (3)H-labelled 5S RNA that hybridized and the dosage of nucleolar organizer region. Thus genes for 5S RNA are located primarily, if not exclusively, outside the nucleolar organizer region. The haploid genome of the wild-type D. melanogaster used in this work has 106 genes for 28S rRNA and 96-105 genes for 5S RNA.


A slow transient kinetic process of yeast hexokinase.


Molecular specificity associated with alleviation of actinomycin D inhibition of protein synthesis.


Enzymic N-acetylation of N-hydroxy-2-aminofluorene by liver cytosol from various species.


Control by light of starch degradation and cell-wall biosynthesis in Platymonas tetrathele.


The amino acid composition of a wheat-based brewing syrup.


The isolation and some properties of a factor causing gelling in the phloem sieve-tube exudate of the squash plant (Cucurbita pepo).


L-tyrosine decarboxylase from barley roots.


The reaction of malonaldehyde with wheat flour proteins.


The effects of depletion of unsaturated fatty acids on the energy-dependent reactions of yeast mitochondria.


The Brook Reaction Test as a measure of temperament with children of 13 and 14 years.


Dietary carbohydrate and fatty acid synthetase activity in rat liver and adipose tissue.


Induction of a new hepatic microsomal haemoprotein by safrole and isosafrole.


Effect of inducers of drug-metabolizing enzymes on diethylnitrosamine metabolism and toxicity.


Effects of administration and scoring on divergent thinking tests.


Modification of deviant classroom behaviour.


Convergent and divergent abilities in children and teachers' ratings of competence and certain classroom behaviours.


A study of the Jesness personality inventory with Scottish children.


Exclusion of serum factors in the in-vitro depression of lymphocytes' response to mitogens in chronic lymphocytic leukaemia.


The spermatogonial stem cell population in adult rats. II. A radioautographic analysis of their cell cycle properties.


The spermatogonial stem cell population in adult rats. 3. Evidence for a long-cycling population.


Mechanism of eosinophilia. V. Kinetics of normal and accelerated eosinopoiesis.


Mechanism of eosinophilia. VI. Eosinophil mobilization.


Application of the phenol-hypochlorite reaction to measurement of ammonia concentrations in Kjeldahl digests of serum and various tissues.


Rapid solubility test for detection of hemoglobin S.


An initial reaction rate assay for "glycerate dehydrogenase".


Evaluation of a spectrophotometric method for determination of total fecal lipid.


Methoxylated phenyl benzo- -pyrone derivatives (flavonoids) that highly inhibit erythrocyte aggregation.


Sodium thymolphthalein monophosphate: a new acid phosphatase substrate with greater specificity for the prostatic enzyme in serum.


Abnormal concentrations of nickel in serum in cases of myocardial infarction, stroke, burns, hepatic cirrhosis, and uremia.


Improved semiautomated method for assay of phosphorus in serum phospholipids.


Rapid column-chromatographic measurement of orotic acid.


The regulation of glyceride synthesis from pyruvate in isolated fat cells. The effects of palmitate and alteration of dietary status.


Control of fatty-acid oxidation in brown-adipose-tissue mitochondria.


Hydride transfer in the biosynthesis of uridine diphospho-apiose from uridine diphospho-D-glucuronic acid with an enzyme preparation of Lemna minor.


Effect of emetine on ribonucleic acid biosynthesis in HeLa cells.


Biosynthesis and secretion of yeast invertase. Effect of cycloheximide and 2-deoxy-D-glucose.


Glutamine and glutamate as respiratory substrates of rabbit reticulocytes.


Apo- and reconstituted holoenzymes of metapyrocatechase from Pseudomonas putida.


Dissociation of Pila haemocyanin at low ionic strength.


Determination of the stability constant of the magnesium-ion complex of isocitrate.


Studies on adenosine deaminase. 1. Purification and some properties of bovine placental adenosine deaminase.


Studies on the mechanism and stereospecificity of the urocanase reaction.


Studies on adenosine deaminase. 2. Specificity and mechanism of action of bovine placental adenosine deaminase.


Selective, reversible loss of elastolytic activity of elastase and subtilisin resulting from electrostatic changes due to maleylation.


The isolation and characterization of the isoenzymes of rabbit-muscle triosephosphate isomerase.


A quantitative analysis of proflavine binding to polyadenylic acid, polyuridylic acid, and transfer RNA.


Interchain disulfide bond formation studied in two mouse myelomas which secrete immunoglobulin A.


The carrier effect in the secondary response to hapten-protein conjugates. IV. Uptake of antigen in vitro and failure to obtain cooperative induction in vitro.


C1 inactivator protein complexed with albumin in plasma from a patient with angioneurotic edema.


Plasma progesterone levels in the pregnant mare's serum (PMS)-treated immature female rat.


Tobacco mosaic virus specific immunoglobulins from horse serum. II. Structural specificity and association constants.


Response to gonadotrophins in mature and immature diabetic female rats.


Estradiol benzoate (EB)-induced changes in serum-luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in immature female rats.


Return of fertility following discontinuation of three-month contraceptive injections of DMPA plus routine oral estrogen supplement: a preliminary report.


The genetic location of prophage on the chromosome of Streptomyces coelicolor.


Cleavage of rabbit ova inseminated in vitro after removal of follicular cells and zonae pellucidae.


Reversion of aryl sulfataseless mutants of Neurospora.


Studies with purple adenine mutants in Neurospora crassa. VI. The effects of differences in genetic background on ad-3A x ad-3B crosses.


Evidence for meiotic recombination in Ascobolus involving only one member of a tetrad.


Serum protein polymorphisms among Norwegian Lapps. Studies on the Lp, Ag, Gc and transferrin systems.


A study of children of incestuous matings.


Red cell phosphoglucomutase polymorphism in Finland-Swedes, Finns, Finnish Lapps, Maris (Cheremisses) and Greenland Eskimos, and segregation studies of PGM types in Lapp families.


Studies on the immunoglobulin allotypes of asiatic populations. I. Gm and Inv allotypes among Chinese from Kuantung Province.


Human red cell adenylate kinase polymorphism in West Malaysian populations.


Alpha-thalassaemia in newborns in West Malaysia.


The a-d ridge count in palmar dermatoglyphics of the three groups of Mysore Brahman.


Dermatoglyphics in schizophrenic patients.


Hand clasping and arm folding among the Manipuris (India).


Genetic aspects of hemophilias A and B in Rio Grande do Sul, Brazil.


On the stability of cis and trans amide bond conformations in polypeptides.


A reporter group at the active site of acetoacetate decarboxylase. I. Ionization constant of the nitrophenol.


The x-ray structures of 7-aminofurazano (3,4-d)pyrimidine and 7-amino-1,2,5-thiadiazolo(3,4-d)pyrimidine.


A reporter group at the active site of acetoacetate decarboxylase. II. Ionization constant of the amino group.


Crystal and molecular structure of kromycin.


Crystal and molecular structure of 5,12a-diacetyloxytetracycline.


A proton magnetic resonance study of polydeoxyriboadenylic acid.


Specific reduction of E prostaglandins to F    prostaglandins and prostaglandin E 2  to prostaglandin E 1 .


Orientation effects in reactions of acyl chymotrypsins.


The structure of saxitoxin.

The structure of saxitoxin.


Mammalian deoxynucleoside kinases. IV. Deoxythymidine kinase: purification, properties, and kinetic studies.


Biochemistry of visual pigments. II. Phospholipid requirement and opsin conformation for regeneration of bovine rhodopsin.


The relationship between the insulin-binding capacity of fat cells and the cellular response to insulin. Studies with intact and trypsin-treated fat cells.


Thallium-205 nuclear magnetic resonance study of pyruvate kinase and its substrates. Evidence for a substrate-induced conformational change.


Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system.


Plasma membrane protein subunit composition. A comparative study by discontinuous electrophoresis in sodium dodecyl sulfate.


The regulation of ketogenesis from oleic acid and the influence of antiketogenic agents.


Lysine, a precursor of carnitine in the rat.


Modern concepts in surgery of liver trauma.


Haemostatic defects of the musculo-skeletal system.


Psychiatric aspects in Parkinsonism treated with L-dopa. Psychiatric aspects of patients with Parkinsonism treated with L-dopa are described. These include acute psychosis in patients with or without previous psychiatric illness and worsening or improvement of pre-existing psychiatric conditions. Therapeutic management is discussed The relevance of these studies to the understanding of the psychiatric aspects of Parkinsonism in general is discussed.


Ulcerative colitis. A clinical study of 399 patients.


Classification of the severity of ulcerative colitis.


New liver clamps.

New liver clamps.


Chronic atherosclerotic occlusion of the lower limbs treated by direct arterial surgery. A review of 70 cases.


Progestins as treatment in generalized progressive scleroderma.


The hypolipidemic effect of SU-13,437 in rats with natural endogenous hypertriglyceridemia.


Fatty acid specificity of glyceride synthesis by homogenates of bovine mammary tissue.


The in vivo incorporation of labeled linoleic acid,  -linolenic acid and arachidonic acid into rat liver lipids.


Response of rat adrenal cholesteryl esters to cold stress.


A comparison of triglyceride, monoglyceride, and phospholipid substrates for post-heparin lipolytic activities from normal and hypertriglyceridemic subjects.


Cholesterol esterification and cholesteryl ester hydrolysis by rabbit and human ovaries.


The effect of a fat free diet on esterified monoenoic fatty acid isomers in rat tissues.


Isolation and identification of cholesterol -oxide and other minor sterols in human serum.


The structures of triglycerides from atherosclerotic plaques and other human tissues.


Early steps on the in vivo incorporation of 1- 14 C-linoleic acid into liver lipids from normal and essential fatty acid deficient rats.


Metabolism of phospholipid in mammary gland. I. The supply of phospholipid for milk synthesis in the rat and goat.


Caring for paraplegics and quadriplegics.


Lipid composition of human bronchial mucus.


Urinary calculi. Clinical, biochemical and radiological studies in 619 patients.


The staghorn calculus. An immediate indication for nephrolithotomy.


The effect of publicity on oral contraceptive practice.


Folic acid deficiency in patients receiving anticonvulsant drugs.


Subcutaneous meningioma.

Subcutaneous meningioma.


Barium infiltration of the rectal wall.

Barium infiltration of the rectal wall.


Methotrexate-induced congenital malformations.


The care of blood during transport and in hospitals.


Subacute myelo-optic neuropathy and the halogenated hydroxyquinolines.


Cerebrovascular disease occurrence in Australia.


Rubella immunization: the problem of non-converters.


Diet and tradition in an African culture.


Pensioner medical service: pharmaceutical benefits.


The management of stuttering.

The management of stuttering.


The medical management of rheumatoid arthritis and the relationship between the rheumatologist and the orthopedic surgeon.


Rehabilitation medicine for the patient with arthritis.


Surgery of the rheumatoid elbow.

Surgery of the rheumatoid elbow.


Vitallium mold arthroplasty and femoral prosthetic replacement in the surgical management of rheumatoid arthritis in the hip.


Probable place of total hip arthroplasty in rheumatoid arthritis involving the hip.


Synovectomy of the knee.

Synovectomy of the knee.


The quest for the replacement knee.

The quest for the replacement knee.


Arthrodesis of the knee.

Arthrodesis of the knee.


Management of the foot in rheumatoid arthritis.


Epilogue. A panel discussion of rheumatoid arthritis and its management.


Juvenile rheumatoid arthritis.

Juvenile rheumatoid arthritis.


Data processing of radiosotope images for optimum smoothing.


Dosimetry of --mesons using silicon detectors and plastic scintillators.


The 1971 meeting of ICRP.

The 1971 meeting of ICRP.


Standardization of nuclear medicine instrumentation.


Seminars in hematology.

Seminars in hematology.


Family centered therapy of the scapegoat child.


Actalasemia and hypocatalasemia in the Orient.


The smallpox situation.

The smallpox situation.


Sanitation in natural disasters.

Sanitation in natural disasters.


Safety of food additives and solvents.

Safety of food additives and solvents.


Science, technology and responsibility.

Science, technology and responsibility.


Laminar profile analysis of the tectal evoked response in the teleost Eugerres plumieri.


Excitability characteristics of field and unitary potentials in optic tectum of fish.


Lactate-pyruvate ratio in muscular work.


Renal function in the hibernating hedgehog.


Effects of increased work load in vitro on heart protein synthesis.


Increased mechanical efficiency in contracting skeletal muscle induced by isoproterenol.


Inhibition of palatal and laryngeal reflexes by afferent stimulation.


Initial ventilatory response during muscular exercise in man.


Effects of blocking the autonomic nervous system during exercise.


Effect of long-term administration of thyrocalcitonin on the skeleton of calcium-depleted rats.


Central regulation of ADH-release in the conscious goat.


Effect of acetylcholine on the efflux of calcium-45 from the perfused cat submandibular gland.


Smooth muscular hypertrophy of a medium-sized artery following a local drop in pressure and an enormous increase in blood flow.


Effect of prostaglandin F 2   on airway resistance in man.


The effects of "immunosympathectomy" on blood pressure and vascular "reactivity" in normal and spontaneously hypertensive rats.


Electrical stimulation of the brain and learning in the cat.


A latency in the activation of lipolysis in adipose tissue during nerve stimulation.


Catecholamines, monoamine oxidase and cholinesterase activity in the human sympathetic ganglion.


Hormonal regulation of ovarian phosphorylase activity.


The effects of K plus -free solution on tension development in the smooth muscle taenia coli from the guinea pig.


Effects of parasympathomimetic agents and vagal stimulation on the flow in the pancreatic duct of the cat.


Interactions between sugar and amino acid transport in rat jejunum.


Effects on left ventricular dimensions of saline loading at different levels of adrenergic activity.


The quantitative inhibition of triton lipemia with heparin in rats.


Effects of selective arm- and leg training on cardiac output and regional blood flow.


Hyperosmolarity and pulmonary vascular capacitance.


The effects of changes in the ionic environment on venous smooth muscle distribution of sodium and potassium.


Spectral sensitivity of the compound eye in three Heliconus species.


Skin circulation in the cheeks of Arctic populations and adaptation to cold.


Extrapleural measurements of blood flow in the arch of the aorta with electromagnetic flowmeter.


A note on knee-joint denervation and postural reflexes in the cat.


A closed chamber for microelectrode recording from the brain.


Cerebral blood flow and cerebral energy state.


Critical oxygen tensions in the brain.

Critical oxygen tensions in the brain.


Induction of midtrimester abortion by intra-amniotic administration of prostaglandin F 2  . A preliminary report.


Stimulation and recording with closely spaced microelectrodes.


Gastric acid response to distension of the stomach in man.


Effect of strenuous arm and leg training on pulmonary ventilation, metabolism and blood pH during submaximal exercise.


The hemodynamic consequences of regional hypotension in spontaneously hypertensive and normotensive rats.


Optimum dose in excretory urography. Preliminary report.


Cerebrospinal fluid transfer of contrast material at urography.


Renal pseudotumors due to ectopic accessory renal arteries: the angiographic diagnosis.


The arterial supply of horseshoe kidneys.


Milk of calcium in the kidney. Diagnostic features of vertical beam roentgenograms.


Compensatory renal hypertrophy. Absence in utero and development in early life.


Klippel-Feil syndrome with renal agenesis and other anomalies.


Arteriographic changes in compensatory renal hypertrophy. An experimental study in dogs.


Bilateral ovarian vein syndrome.

Bilateral ovarian vein syndrome.


Roentgenographic manifestations of pyruvate kinase deficiency hemolytic anemia.


Vascular key to diagnosis of pulmonary interstitial diseases.


The appearance of cardiovascular monitoring and assistance devices on chest roentgenograms.


Complications in vertebral angiography as compared to non-vertebral cerebral angiography in 447 studies.


Roentgenographic manifestations of congenital coronary artery disease.


Angiographic demonstration of bidirectional coronary artery blood flow following aorto-coronary bypass vein grafts.


An improved technique for right coronary artery catheterization.


The role of sodium in promoting ventricular arrhythmia during selective coronary arteriography.


The use of a constant pressure pump for maintaining the patency of catheters and needles during angiography.


A fluoroplanigraphy system for rapid presentation of single plane body sections.


The mode of telepaque absorption from the intestine.


Acute renal failure after excretory urography in multiple myeloma.


Epidermoid carcinoma of the mobile tongue. Treatment by partial glossectomy alone.