The role of Wayne State University College of Pharmacy in the development of an innovative and comprehensive health care program.


Essential hypertension.

Essential hypertension.


'I shot an arrow in the air' the performing arts as weapons of social change.


Open- and closed-mindedness and recognition of visual humor.


Diagnosis of streptococcal pharyngitis: differentiation of active infection from the carrier state in the symptomatic child.


Serum-mediated immune cellular responses to Brucella melitensis. 7. The separation and assay of serum globulins responsible for macrophage stimulation and Brucella inhibition.


Vaccination against smallpox in the United States--a re-evaluation of the risks and benefits.


The uses of research.

The uses of research.


Double vagina with double uterus (didelphys) containing endometrial adenocarcinoma. Report of a case.


Disseminated intravascular coagulation in children.


Blow-out fracture of the orbit.

Blow-out fracture of the orbit.


The management of cervical metastasis in head and neck cancers.


Prognosis of hearing loss in temporal bone fractures.


Anticipatory elicitation of the middle-ear muscle reflex.


Tympanic membrane grafting: animal and tissue culture experiments.


Experimental studies on closing of artificial eardrum perforations in rabbits.


Hearing loss in missile head injuries.

Hearing loss in missile head injuries.


Postoperative cholesteatoma recurrence through the posterior wall.


Primary tuberculosis otitis media.

Primary tuberculosis otitis media.


Adenolymphoma of submandibular salivary gland.


Papilloma of the trachea.

Papilloma of the trachea.


UAB school of medicine--after 25 years.

UAB school of medicine--after 25 years.


Ludwig's angina, a sleeper.

Ludwig's angina, a sleeper.


Id, ego and superego revisited.

Id, ego and superego revisited.


Thyroxine analogs. 20. Substituted 1- and 2-naphthyl ethers of 3,5-diiodotyrosine.


6-amino derivatives of stigmastanol and cholestanol.


(2,4-Dileucine)exytocin. A polypeptide with natrituretic and diuretic activities, and an inhibitor of the oxytocic response of oxytocin.


Synthesis of 1-methyl-1-(substituted benzyl)hydrazines.


Synthesis and hypotensive activity of benzamidopiperidylethylindoles.


Quaternary pilocarpine derivatives acting as acetylcholine antagonists.


Synthesis and hypotensive properties of new 4-aminoquinolines.


Benzimidazo[2,1-b]quinazolin-12-ones. A new class of potent immunosuppressive compounds.


Synthesis and antiinflammatory activity of tert-aminomethylbenzophenones.


Derivatives of 2-aminooxazoles showing antiinflammatory activity.


Molecular orbital calculations on coumarins and the induction of drug-metabolizing enzymes.


Central nervous system agents. 1. Synthesis of diphenyl-tert-aminopropanols.


Central nervous system agents. 2. Synthesis of diphenyl primary and secondary aminopropanols.


Preliminary studies on the antitumor activity of some phosphatidyl nitrogen mustard derivatives.


Central nervous system agents. 3. Structure-activity relationship of a series of diphenylaminopropanols.


New thio derivatives of carcinogenic arylamines. 5. Ring-substituted methylthio-4-acetamidostilbenes.


Antitumor activities and rats of hydrolysis of Schiff bases.


Potential antitumor agents. 1. Analogs of camptothecin.


Synthesis and antifungal activity of substituted carbanilic acid esters.


Cobalt chelates of Schiff bases of aromatic amines as antitumor agents.


Absence of biochemical and pharmacological effects of the trypsinogen activation peptide.


Antimalarials. 8. 2,3-Trimethylene-4-quinoline amino alcohols. 5,7-Dichloro-2,3-dihydro-1H-cyclopenta[b]quinoline-9-(alpha-di-n-butylaminomethyl)methanol.


N,N-alpha,omega-alkylenebis(nitroacetamides).


Tricyclic heterocycles derived from 4-oxo-4,5,6,7-tetrahydrothianaphthenes.


Synthesis and alkylation of tetrahydropyrrolo[3,4-c]pyrazoles.


Synthesis of derivatives of N,N-dimethylhydrazine and their physiological activities.


Analogs of amphetamine. 6. 2,5-Dimethoxy-4-methyl- and 2,5-dimethoxy-alpha,4-dimethylphenylalanines.


Comparisons of butyrylcholinesterase inhibitory potencies of selected 3-substituted-1-decylpiperidines with their electron charge densities.


Single crystal x-ray structures of chemotherapeutic agents. 3. Structure of 1,4-diazabicyclo[2.2.1]heptanes, a new heterocyclic ring system.


Synthesis of enantiomeric chloroacetylcarnitine chlorides.


3-amino-4-hydroxy-L(-)-butyramide hydrochloride.


Message from the president of the Industrial Medical Association.


Solid phase synthesis of [4-proline]oxytocin, [4-proline]mesotocin, [4-proline]glumitocin, and [4-lysine]mesotocin.


A comprehensive medical care delivery system born in industry.


Industry's role in the delivery of health care.


Pneumoconiosis in ferrosilicon workers. A follow-up study.


Varicose veins.

Varicose veins.


The antecedents of myocardial infarction and sudden death in a cohort of actively employed men.


The occupational physician and medical care delivery system.


The private physician's obligation to industry.


Kinetics of absorption and excretion of levodopa in dogs.


Kinetics and mechanisms of lactonization of coumarinic acids and hydrolysis of coumarins. II.


Determination of organically bound fluorine using sodium biphenyl reagent and a fluoride-specific ion electrode.


Behavior of erythrocytes in phosphate buffer systems.


Drug-absorption analysis from pharmacological data. II. Transcorneal biophasic availability of tropicamide.


Cardiovascular effects of bulbocapnine.

Cardiovascular effects of bulbocapnine.


Physiologic disposition and metabolic fate of indomethacin analogs. I. 1-p-chlorobenzylidenyl-5-methoxy-2-methylindene-3-acetic acid.


Physiologic disposition and metabolic fate of indomethacin analogs. II. 1-(p-chlorobenzoyl)-5-dimethylamino-2-methylindole-3-acetic acid.


GLC determination of dl-2-(3-phenoxyphenyl)propionic acid (Fenoprofen) in human plasma.


Accelerated peritoneal dialysis of barbiturates, diphenylhydantoin, and salicylate.


GLC assay method for neomycin in petrolatum-based ointments.


GLC analysis of multicomponent suppository formulations.


Kinetic simulation by digital computer using graphic display techniques.


Unsymmetrical carbonates as potential long-lasting insect repellents.


Structure elucidation of maytenonic acid, a new triterpene from Maytenus senegalensis (celastraceae).


Agents for alkylating steroid hormone receptors. 3. Omega-substituted esters of 17-alpha-hydroxyprogesterone. The synthesis and Clauberg activity of the 8-carbomethoxyoctanoate (IIe), 9-carbomethoxynonanoate (IIf), 9-carboethoxynonanoate (IIg), 9-carbo-tert-butoxynonanoate (IIh), 8-carboxyoctanoate (IIId), 9-oxo-10-diazodecanoate (IVd),  5-oxo-6-hydroxyhexanoate (Va), and 6-oxo-7-hydroxyheptanoate (Vb) esters of 17-alpha-hydroxyprogesterone are reported in this article.  Esters IIa-IIe and IIe-IIh were tested by the McPhail modification of the Clauberg assay.  The progestational activity increased with chain length for the glutarate ester IIa through the pimelate ester IIe.  It then decreased slightly for the azelate ester IIe and decreased further for the methyl and tert-butyl sebacates IIf and IIh.


Spectrophotofluorometric determination of salicylamide in blood serum and urine.


Sulfur-containing derivatives of beta-phenethylamine: methanesulfonamides.


Occurrence and distribution of phenoxazinone pigments in the genus Pycnoporus.


Spasmolytics. IV. Azo and azoxy derivatives of 3-tropanyl 2,3-diarylacrylates.


Estimation of diffusion coefficients and molecular weights of interacting colloids from dissolution-rate data.


Aminotetrahydrofuranol derivatives.

Aminotetrahydrofuranol derivatives.


Effect of calcium ions on the scattering of light by heparin.


Tablet absorption in the rat.

Tablet absorption in the rat.


A doctor's skill in understanding other people.


Loss from the small intestine.

Loss from the small intestine.


Sodium depletion in chronic renal failure.


The integration of treatment for malignant disease.


Infection, the environment and chronic bronchitis.


Contamination in countryside and home.

Contamination in countryside and home.


Priorities in the control of environmental pollution.


Air pollution and community health.

Air pollution and community health.


Occupational exposures to pollution.

Occupational exposures to pollution.


The effect of drugs on the electrical and mechanical activity of the isolated perfused canine stomach.


The duodenal pacemaker and its rôle in the organisation of duodenal activity.


The function of biliary "sphincters".

The function of biliary "sphincters".


Duodenal intubation studies.

Duodenal intubation studies.


Late results of colomyotomy.

Late results of colomyotomy.


On the cause of gastric and duodenal ulcers.


Lateral femoral hernia.

Lateral femoral hernia.


Induction of labor. II. An invitational symposium.


Growth of leiomyomata with estrogen--progestogen therapy.


Action of sennosides and related compounds on the human colon.


Pregnancy and progeny after hormonal contraceptives--genetic studies.


Some aspects of cancer of the stomach.

Some aspects of cancer of the stomach.


A simple approach to follow the metabolic degradation of cardiac glycosides in vivo.


Mortality after high ligation of the anterior descending branc of the left coronary artery in dogs; effects of various pharmacological agents.


Quantitation of glomerular structure. A study of methodology.


Induction of polyploidy in the rat exocrine pancreas by excess dietary methionine.


Mitochondrial-tubular membrane interconnections in the rat adrenal cortex.


The conduct of an operation.

The conduct of an operation.


How to diagnose occupational disease.

How to diagnose occupational disease.


An example of alcoholism treatment in the United States.


Toxoplasmosis.

Toxoplasmosis.


Studies of sudden death and myocardial infarction in Baltimore City.


The management of stuttering.

The management of stuttering.


Artificial ventilation of newborn infants.


Management of respiratory problems in the newborn.


Artificial ventilation in respiratory failure in the newborn.


Interference hazards with Australian non-competitive ("demand") pacemakers.


Ergonomics of diathermy forceps design.

Ergonomics of diathermy forceps design.


Plasma levels of lignocaine after intramuscular injection.


Rheumatoid factor testing of serum and synovial fluid, with comparative evaluation of a new haemagglutination test.


Detection and treatment of inapparent "blue spells" in the seriously ill patient with tetralogy of fallot.


Medical care and the Asian student in Australia: an inquiry.


Group relaxing hypnosis.

Group relaxing hypnosis.


The most common fee.

The most common fee.


National Health Service.

National Health Service.


The cost to the patient of specialist services.


Results of obstetric practice in a suburban private hospital.


Prescribing barbiturates.

Prescribing barbiturates.


Therapeutics--a neglected speciality?

Therapeutics--a neglected speciality?


The professional provident fund.

The professional provident fund.


Successful hemicolectomy for carcinoma in a nonagenarian.


The organization of medical care.

The organization of medical care.


Lymphocytic transformation as a diagnostic test in allergic conditions.


Delivery of rehabilitation services to the Community.


Section of armed forces and aerospace medicine.


Investigations of the bipartite structure of the white-albino maize mutants.


Aspects of increased vascular permeability following the intradermal injections of histamine in the rat.


Effects of progesterone, ovariectomy and adrenalectomy on mammary tumours induced by 7,12-dimethylbenz(a)anthracene in Sprague-Dawley rats.


Pseudosarcoma of the skin.

Pseudosarcoma of the skin.


The reaction of urethane with mouse liver nucleic acids in vivo.


Fibrinogen derivatives in particle aggregation by peritoneal contents.


Intravascular haemolysis, platelet consumption and platelet adhesiveness in patients with prosthetic heart valves.


Lack of adrenergic nerves in the circular smooth muscles of ductus arteriosus persistens.


Pulsatile flow studies of prosthetic aortic valves.


Arterio-venous fistulae of the coronary arteries. A report of six cases.


Traumatic rupture of the thoracic aorta. Case report.


Increased erythrocyte sedimentation rate following anti-thrombotic treatment with dextrans.


Management of instrumental and spontaneous (atraumatic) perforations of the oesophagus.


Rheologic and metabolic studies in the vascular bed of the leg after arterial reconstruction, at rest and during exercise.


Congenital posterolateral diaphragmatic hernia in infants.


Infantile lobar emphysema associated with cardiovascular anomalies. A report on 4 cases, with emphasis on the value of bronchographic examinations.


Problems of navigation.

Problems of navigation.


Autoimmune hemolytic anemia in ulcerative colitis, cured by colectomy. Report of a case.


Acute myocardial infarction in the Copenhagen area in November 1968. Incidence and mortality.


Benefits obtained by the introduction of a coronary-care unit. A comparative study.


Four cases of massive digitalis poisoning.


Lactate dehydrogenase isoenzyme patterns in serum and skeletal muscle in intoxicated alcoholics.


The distribution of proteins between intra- and extravascular spaces in health and disease.


Methoxamine injections in the diagnosis of mitral insufficiency during routine right heart catheterizations.


Prussian blue in therapy of thallotoxicosis. An experimental and clinical investigation.


Fibrinolytic activity in hemiplegic patients.


Forty-five operations for sterility.

Forty-five operations for sterility.


Experiences of a contourograph in ECG-monitoring and arrhythmia diagnosis.


Cytological diagnosis of endometrial disorders with a brush technique.


Ultrastructure of the anchoring villi and trophoblastic shell in the second week of placentation.


Changes in uterine volume following the intra-amniotic injection of hypertonic saline.


Treatment of carcinoma in situ of the cervix uteri by conization. A five-year follow-up.


Response of the pregnant human uterus to low and high doses of prostaglandin E 1  and E 2 .


Placental localization by the gamma camera and Doppler flowmeter.


The use of ultrasonic biparietal diameter measurement of the fetus in assessing gestational age.


Feto-maternal transfusion and free bleeding from the umbilical cord.


The structure of the pulmonary acinus in a child of six years and eight months.


Atrioventricular node and Purkinje fibers of the guinea pig heart.


The effects of cortisol and BUDR on cellular differentiation in the small intestine in suckling rats.


Autoradiographic studies on 14C-leucine incorporation into motor neurons of the spinal cord of x-irradiated mice.


Cerebral cortex of the mouse after prenatal chemical insult.


Lung puncture and aspiration.

Lung puncture and aspiration.


Regional enteritis in early infancy.

Regional enteritis in early infancy.


Subacute bacterial endocarditis in children. Current status.


Nutritional status of preschool Mexican-American migrant farm children.


Sporotrichosis in children.

Sporotrichosis in children.


Maximum daily intake of lead without excessive body lead-burden in children.


Picture of the month. Chondrodystrophia calcificans congenita.


Radiological case of the month. Posterior urethral valves.


A case of renal necrosis and fibrosis in the immediate newborn period. Association with the twin-to-twin transfusion syndrome.


Severe hypertension in identical twin infants.


A conference with the family of a leukemic child.


Antigenic differences in two hog cholera virus strains.


Blood constituent changes associated with hog cholera virus infection of swine.


Streptococcic lymphadenitis of swine: an immune carrier of Streptococcus suis.


Blood constituent changes in fasted swine.


Cardiorespiratory effects of tiletamine in cats.


Effects of chemical inhibition of alkaline phosphatase isoenzymes in the dog.


Instantaneous changes of left ventricular volume in anesthetized horses.


Response of the bovine fetus to bovine viral diarrhea-mucosal disease virus.


Ventriculography in calves.

Ventriculography in calves.


Effects of season and grass tetany on mineral composition of Hereford cattle hair.


Influence of dienestrol diacetate on reproductive performance of female mink (Mustela vision).


Occurrence of myopathy in lambs of ewes fed added arsenic in a selenium-deficient ration.


Organ weights and water composition of the New Zealand albino rabbit (Oryctalagus cuniculus).


The decerebrate state in the primate. II. Studies in man.


Contractile properties of human skeletal muscle. Normal and thyroid disease.


Fiber types and preclinical changes in chicken muscular dystrophy.


Hereditary dystonia associated with unique features in skeletal muscle.


In vitro stimulation of ( 14 C)amino acid incorporation into protein of isolated rat liver nuclei induced by cortisol pretreatment.


Effect of a bacteriocin produced by Enterobacter cloacae on protein biosynthesis.


RNA ratios in dividing and non-dividing cells of pea root.


Optical rotatory dispersion and circular dichroism of mono- and oligonucleotide-amino acids (amidates).


Cold-induced accumulation of ribosomal subunits from human reticulocytes.


Anorexia nervosa.

Anorexia nervosa.


Strengthening general practice.

Strengthening general practice.


Uses of allopurinol.

Uses of allopurinol.


Climate in the theatre.

Climate in the theatre.


International cancer research.

International cancer research.


Surgery of patent ductus arteriosus.

Surgery of patent ductus arteriosus.


Significance of potassium in genesis of arrhythmias in induced cardiac ischaemia. Paired biopsy specimens from the right or left atrial appendage have been taken from patients undergoing cardiopulmonary bypass surgery after various periods of intermittent coronary artery occlusion and analysed for potassium, sodium, and chloride content, total tissue water, and extracellular fluid volume.Tissue potassium content is reduced after coronary artery occlusion, and potassium loss bears an apparently linear relationship to the duration of occlusion. After 150 minutes of occlusion the potassium content had decreased by nearly 50%.For the first 50 minutes of occlusion the myocardial cells swelled at the expense of the extracellular fluid volume. Thereafter there was movement of water in the opposite direction, with subsequent cell shrinkage.The loss of potassium and the alteration in cellular hydration exert profound effects on the calculated gradient of potassium across the cell membrane. This is discussed in relation to the arrhythmias and low cardiac output after myocardial ischaemia. An attempt to rationalize treatment is made.


Smoking risks of different tobaccos.

Smoking risks of different tobaccos. The smoke of English cigarettes (flue-cured tobacco) greatly shortens the life of rats and damages the respiratory system, whereas that of the cigar (air-cured tobacco) is relatively harmless. This bears out two of the principal features in the 1971 Report of the Royal College of Physicians, which draws attention to the large number of premature deaths in cigarette smokers and the comparative safety of smoking cigars.


Metabolic responses to oral glucose in the Kalahari Bushmen. The plasma glucose, immunoreactive insulin, and growth hormone levels after a 50-g oral glucose load have been measured in 15 adult Bushmen subjects living in the Kalahari region of Southern Africa. Compared with 10 non-obese white controls, they showed relative glucose intolerance and significantly impaired insulin secretion. Growth hormone responses showed no significant differences between the two groups. Factors such as inadequate or unusual nutrition and stress do not appear to account completely for the abnormalities in carbohydrate metabolism observed in the Bushmen. Of interest are the clinical and hormonal similarities that seem to exist between the Bushmen and the Central African Pygmies.


Rapid propagation of thrombus in deep vein thrombosis.


Altered calcium metabolism in epileptic children on anticonvulsants. A survey of 105 epileptic children aged 10-16 years at a residential school who were taking anticonvulsant drugs showed reduced serum calcium levels in 30% and a raised serum alkaline phosphatase in 24%. Urinary D-glucaric acid excretion, a quantitative index of hepatic enzyme induction, was raised in 94% of the children, and statistical analysis showed a significant inverse correlation with the level of serum calcium. These findings give further support for the view that an important factor in the development of the hypocalcaemia and occasional clinical osteomalacia in epileptics on anticonvulsant drugs is an alteration of vitamin-D metabolism in the liver as a result of microsomal enzyme induction. As a consequence there is an increased requirement for vitamin D which may not be met by average intakes in Britain.


Lactic acidosis complicating liver failure after intravenous fructose.


Chorea and the oral contraceptives.

Chorea and the oral contraceptives. The case histories are reported of six women who developed chorea while taking oral contraceptive drugs. The chorea that results from taking compounds containing oestrogen and progestogen has many features in common with chorea gravidarum, and the pathogenesis is probably similar. In some of the patients, however, the sudden onset of symptoms suggests a vascular aetiology.


Casual attendances at an accident department and a health centre. In six months patients from a defined population of 11,417 provided 826 casual attendances for minor conditions at a hospital accident department and 1,430 similar attendances at a health centre treatment room. Attendances at the accident department reached a peak during the early evening, and included relatively more males, more adults, more patients with injuries than with symptoms, and more residents from the area immediately adjoining the hospital.Care of most of the casual attenders with minor conditions at the health centre treatment room would require additional nursing staff and some reorganization of primary care to enable a doctor to be available at most times. Attendances at night and at week-ends were insufficient to justify a 24-hour service at the health centre.


Do lymphocytes protect the rheumatoid joint? The pathology of the synovial membrane in rheumatoid arthritis can be characterized by the prominence of two major features which appear to vary independently of one another. These are synovial lining-cell proliferation and infiltration with inflammatory cells, predominantly lymphocytes. In a series of 42 synovectomies from 36 patients it has been shown that extensive joint damage is associated with a synovial picture of marked lining-cell proliferation and a sparsity of lymphocytes. Cases with heavy lymphocyte infiltration tend to show less damage to articular cartilage and bone despite a similar duration of disease. These results have been compared with the picture in leprosy, where a similar pathological spectrum is associated with changes in cell-mediated immunity necessary for the control of infection.


Prevention of coronary deaths.

Prevention of coronary deaths.


Epidemic keratoconjunctivitis.

Epidemic keratoconjunctivitis.


Anaesthesia for cardioversion.

Anaesthesia for cardioversion.


Protein-bound peptides in human serum.

Protein-bound peptides in human serum.


Chorea and occlusion of central retinal artery.


Evidence that glucose load is an important determinant of plasma insulin response in normal subjects.


Effect of local anesthetics on insulin secretion by pancreas pieces.


Carbohydrate-induced hypertriglyceridemia: inhibition by phenformin.


Diabetes in the Pima Indians. Evidence of bimodality in glucose tolerance distributions.


Occurrence and prevalence of diabetic retinopathy in hemochromatosis.


Some observations concerning the post lumbar puncture headache.


Psychological factors in headache.

Psychological factors in headache.


No appointment needed; the headache clinic.


Chronic migrainous neuralgia--diagnostic and therapeutic aspects.


An economic and efficient vasectomy program. Of 305 vasectomies performed between July 1970 and May 1971 at the San Bernadino and Ontario (California) County Health Department Clinics, there was only one minor hematoma of mild significance and two febrile responses.  Written consent is required and the procedure and its effects carefully explained prior to the performance of surgery.  The operation is performed on an outpatient bases at a low cost.


Changing composition of voluntary hospital boards. An inevitable prospect for the 1970's.


Multiagency participation in family planning administration.


Redefining the health problem and implicatons for planning personal health services.


Attitudes of professional students toward legal control of psychoactive substances.


Community medicine on the Navajo Reservation.


A method for measuring physicians' awareness of patients' concerns.


Some medical considerations regarding atmospheric fluorides.


The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vivo.


Blastogenic response of lymphocytes separated from bone marrow to allogeneic lymphoid cells in vitro.


Recognition of foreignness in invertebrates. II. In vitro studies of cockroach phagocytic haemocytes.


The transmissions of antibodies across the gut of pouch-young marsupials.


The differential effect of gamma irradiation on the sensitizing and effector stages of antibody dependent lymphocyte mediated cytotoxicity.


Electrophoretic polymorphism of the fourth component of human complement (C4) in paired maternal and foetal plasmas.


Studies on the effect of macrophages in an in vitro graft reaction system.


The structure of the acidic polypeptide chains from alpha-crystallin. Amino acid composition, peptide mapping, and N-terminus.


Studies on the conformation of amino acids. IV. Conformations of serine, threonine, cysteine, and valine.


Studies on the conformation of amino acids. VI. Conformation of the proline ring as observed in crystal structures of amino acids and peptides.


Hemoglobin Atago (alpha2-85Tyr beta-2) a new abnormal human hemoglobin found in Nagasaki. Biochemical studies on hemoglobins and myoglobins. VI.


Evidence on erythrocyte aminopeptidase B.


Studies on the conformation of amino acids. V. Conformation of amino acids with delta-atoms.


The carboxyl terminal amino acid residues of human and horse prothrombins.


Human pituitary growth hormone. 23. Synthesis of protected peptide fragments occurring in the first 27 amino acid residues.


Application of differential enthalpic analysis to the study of biopolymer solutions.


Human pituitary growth hormone. XXIV. Synthesis of protected peptide fragments occurring in the region of residues 28-52.


Human pituitary growth hormone. XXV. The synthesis of protected peptide fragments occurring in the region of residues 53-67.


Human pituitary growth hormone. XXVI. Synthesis of protected peptide fragments occurring in the carboxyl terminal residues 166-188.


Patterns of family interaction and child-rearing attitudes related to three dimensions of juvenile delinquency.


Thermal pain: a sensory decision theory analysis of the effect of age and sex on d', various response criteria, and 50 per cent pain threshold.


Psychological versus spatial determinants of social schema distance: a methodological note.


Socio-cultural learning and religious habit.


Are the alienated more suggestible?

Are the alienated more suggestible?


Locus of control and immediate affect states.


Psychiatric symptoms observed in normal and disturbed black children.


Effect of stressful physical illness on future time perspective.


Internal-external control and severity of emotional impairment among psychiatric patients.


Absence of intellectual deterioration in chronic alcoholics.


Relapse rates in addiction programs.

Relapse rates in addiction programs.


Perceived ability in relation to actual ability and academic achievement.


A second look at the effects of a stress-producing film on adult test performance.


Antecedent probabilities, cost efficiency, and differential prediction of patients with cerebral organic conditions or psychiatric disturbance by means of a short test for aphasia.


Differential diagnosis of brain damage and schizophrenia by the Memory-for-Designs test.


A comparison of the background interference procedure effect in schizophrenic, nonschizophrenic and organic patients.


The relationships between WISC verbal-performance discrepancies and selected verbal, auditory-perceptual, visual-perceptual, and problem-solving abilities in children with learning disabilities.


A-B "type" status, self-concept, and social competence.


A factor analytic study of the multidimensional properties of impulse control.


A reliability study of interparental agreement on the Rimland Diagnostic Check List.


POI correlates of a religious commitment inventory.


Exploration of attitudes via physical interpersonal distance toward the obese, drug users, homosexuals, police and other marginal figures.


Follow-up study of child guidance clinic patients by means of the Behavior Problem Checklist.


The management of social behavior of chronic psychiatric patients: an empirical analysis of small group behaviors.


Conformity and imitation among hospitalized patients.


Self-concepts of alcoholics before and after treatment.


Change on the Frar Survey Schedule during psychiatric hospitlization.


The effect of remedial reading on covert oral behavior.


The referential nature of psychological constructs.


Glucose 6-phosphatase activity in the intestinal epithelium of the mouse.


Fine structural cytochemical localization of peroxidase activity in rat peritoneal cells: mononuclear cells, eosinophils and mast cells.


Related studies of a recombinant influenza-virus vaccine. I. Derivation and characterization of virus and vaccine.


Correlated studies of a recombinant influenza-virus vaccine. II. Definition of antigenicity in experimental animals.


Correlated studies of a recombinant influenza-virus vaccine. IV. Protection against naturally occurring influenza in military trainees.


Type-specific streptococcal antibodies in pyodermal nephritis.


The role of domestic animals in the epidemiology of plague. II. Antibody to Yersinia pestis in sera of dogs and cats.


The role of domestic animals in the epidemiology of plague. I. Experimental infection of dogs and cats.


Potential acetylcholinesterase reactivators. p,p-Biphenyl and 1,4-benzene disubstituted oximes.


Synthesis and hypoglycemic activity of 3-aryl(or pyridyl)-5-alkyl(or aryl)amino-1,3,4-thiadiazoles and some sulfonylurea derivatives of 4H-1,2,4-triazoles.


Central nervous system active butyrophenones. 1. Unsaturated analogs of  -aminobutyrophenones.


Synthesis and pharmacological activity of dialkylaminoethyl esters and amides of phenylmercaptoacetic acid and its derivatives.


Central nervous system active butyrophenones. 2. Methyl-branched  -aminobutyrophenones.


Quaternary isothiazolylpyridinium salts. Oral hypoglycemic agents.


Synthesis and analgetic activity of 1,5-methano-3-methyl-1,2,3,4,5,6-hexahydro-3-benzazocines.


Aldehyde disubstituted aminoacethydrazones as potential hypertensive agents.


Synthesis of new urethans. p-Cyclohexylsulfamoyl and p-piperidinosulfonylcarbanilic acid esters.


1-substituted-3,3-dimethylspiro(indoline-2,3-thietane) 1,1-dioxides derived from 2-methyleneindolines.


Synthesis of L-Dopa (3,4-dihydroxyphenyl-L-alanine).


Evaluation of carbazoles as antifungal agents.


Phosphorus-nitrogen compounds. 13. Methoxyethyl and propylamine derivatives.


Synthesis and antihypertensive activity of 2-arylamino-1-azacycloalkenes.


Antimalarial phenanthrene amino alcohols.1. Fluorine-containing 3- and 6-substituted 9-phenanthrenemethanols.


Antimalarials. 7. Bis(trifluoromethyl)- -(2-piperidyl)-4-quinolinemethanols.


Studies in potential filaricides. 5. 3-Ethyl-8-methyl-1,3,8-triazabicyclo(4.4.0)decan-2-one, a new antifilarial agent.


Specificity in enzyme inhibition. 1. Synthesis of 4-(4-imidazolyl)-3-amino-2-butanone, 4-(4-imidazolyl)-3-acetamido-2-butanone, and 4-(4-imidazolylmethyl)-2,5-dimethyloxazole for assay as inhibitors of histidine decarboxylase.


Antiestrogenic and antifertility compounds. 4. 1,1,2-Triarylalkan-1-ols and 1,1,2-Triarylalk-1-enes containing basic ether groups.


Heterocyclic steroids. 2. Synthesis and androgenic activity of A-ring oxaandrostanes.


Heterocyclic steroids. 3. An androgen having three heteroatoms in ring A.


Antiulcer agents. p-Aminobenzamido aromatic compounds.


Synthesis and analgetic properties of compounds containing an exocyclic basic center.


Antiinflammatory 3,4-dihydro-2-alkyl-3-oxo-2H-1,2-benzothiazine-4-carboxamide 1,1-dioxides.


Chemistry and pharmacology of 5-methylene-4-substituted dibenzo(a,d)cycloheptenes.


cis-1-(2-(p-anisidinomethyl)cyclohexyl)piperidine and related compounds. Oral hypoglycemic agents.


Studies on heterocyclic systems. 1. 1-Substituted 1,2-dihydro-2-nitroiminopyridines.


Synthetic biologically active polymers. 9. Comparison of antimalarial activity in copolymers containing common sulfonamide monomers but different comonomers.


Biologically oriented organic sulfur chemistry. 9. Carbonyl and thiocarbamoyl disulfides as inhibitory agents for Histoplasma capsulatum.


Syntheses and screening of some trifluoromethyl pyrazoles.


Structure of the diuretic merbaphen.

Structure of the diuretic merbaphen.


Metal chelate steroid analogs. 2. (7-Amino-8-(aminomethyl)-1,2,3,4,4a,4b,5,6,7,8,8a,9-dodecahydro-4a,7-dimethyl-2-phenantrhol)-bis(ethylenediamine)cobalt(3+) trichloride  -acetate (ester).


Neoplasms of the adrenal gland.

Neoplasms of the adrenal gland.


Cephaloglycine as a urinary antimicrobial in patients with reduced renal function.


Acute renal failure following high dose excretory urography in dehydrated patients.


Mannitol intoxication.

Mannitol intoxication.


Diagnostic arteriography in persistent or recurrent renal cell carcinoma.


Ruptured abdominal aortic aneurysm presenting with gross hematuria.


Renal arteriovenous fistula: unique finding in the Marfan syndrome.


Renal vein thrombosis treated by thrombectomy: a case report.


Renal caliceal axis sign.

Renal caliceal axis sign.


Tumors of the renal pelvis: clinical review with emphasis on selective angiography.


Simultaneous occurrence of hypernephroma and transitional cell carcinoma with development of transitional cell carcinoma in the opposite kidney: case report.


Management of urinary drainage following lithotomy.


Congenital uretero-seminal vesicle fistula.


Bilateral ureteral obstruction due to cancer of the pancreas.


Primary adenocarcinoma of ureter: a case report.


Air cystometry. I. Technique and definition of terms.


Ureterosigmoidostomy with colocolostomy: a technique of sigmoid exclusion after ureteral implantation into sigmoid.


Rupture of the bladder secondary to uterine vacuum curettage: a case report and review of the literature.


Phenacetin abuse causing bladder tumor.

Phenacetin abuse causing bladder tumor.


Repair of the recurrent fistula of the penile urethra.


The diagnostic value of urinary cytology in patients with bladder carcinoma.


Fracture of the penis: rationale of surgical management.


The pathophysiologic basis for the clinical manifestations and complications of transurethral prostatic resection.


Treatment of stage 1 carcinoma of the prostate: a preliminary report.


Urologic aspects of sickle cell hemoglobin.


A device to free the legs from pressure of rubber urinary drainage bags.


Cushing's syndrome in a 10-year-old girl associated with a benign adrenal adenoma.


Abdominal masses in the newborn: 63 cases.


Multicore disease. A recently recognized congenital myopathy associated with multifocal degeneration of muscle fibers.


Comparison of simultaneous clearances of 125-I-labeled sodium lothalamate (Glofil) and of inulin.


Basal and stimulated insulin levels: comparison of insulinogenic effects of oral glucose and intravenous tolbutamide in nondiabetic and diabetic subjects.


Characteristics of cystine and lysine transport in renal jejunal tissue from cystinuric dogs.


Oral glucose tolerance, plasma insulin, and uric acid excretion in man during chronic administration of nicotinic acid.


Ascorbic acid metabolism in adrenalectomized rats.


Effects of training and of acute exercise in trained rats.


Effect of carrier on organ distribution of 75Se-Selenomethionine.


Depression of plasma lipid fractions and inhibition of platelet aggregation by action of glucagon.


Pion stopping region visualization experiments.


Event simultaneity in cavities. Theory of the distortions of energy deposition in propotional counters.


Reductive deamination of oligopeptides by solvated electrons in aqueous solution.


Cytokinetic effects of repeated x-irradiation in vivo in the presence of a circadian rhythm in mitotic activity.


Effects of irradiated diets on production of progeny by several successive generations of the Indian-meal moth, Plodia interpunctella (Hübner).


Effect of gamma irradiation on the chicken retina.


The relative effectiveness of fission neutrons for miniature pig performance decrement.


Long-term hematological effects of internal emitters in beagles.


Behavior of swine leukocytes in culture after in vivo or in vitro exposure to 14 MeV neutrons.


The postnatal response of four organs to prenatal irradiation as measured by changes in nucleic acids and protein.


The involvement of thiol groups in determining radiation responses of lactic acid bacteria.


Radiation responses in lactic acid bacteria in relation to adaptive alterations in fermentative pathways.


Long-term effects of radiation on the vascularity of rat bone--quantitative measurements with a new technique.


Distribution of strontium-85 in conceptuses of the pregnant rat.


Survival patterns of mice after two-dose and three-dose fractionation regimens.


Analysis and purification of biological stains by gel filtration.


Demonstration of the microvasculature of the spinal cord by intravenous injection of the fluorescent dye, thioflavine S.


Clinicopathologic conference.

Clinicopathologic conference.


Experimental studies of cardiac function during irreversible hemorrhagic shock.


Multiple anesthetics: what choice?

Multiple anesthetics: what choice?


Management of venous thromboembolic disease.


Cardiac catheterization and cine coronary arteriography in a community hospital.


L-asparaginase production by various species of Salmonella.


Effect of heat on seed transmission of mosaic disease of cowpea (Vigna sinensis Savi).


Thrombosis of the inferior vena cava following balloon septostomy in transposition of the great arteries.


Coexisting intra- and subnodal block: an unusual abnormality of atrioventricular conduction.


Dicrotism in heart disease. Correlations with cardiomyopathy, pericardial tamponade, youth, tachycardia, and normotension.


Exercise test, history, and serum lipid levels in patients with chest pain and normal electrocardiogram at rest: comparison to findings at coronary arteriography.


Wedge arteriography for the identification of pulmonary emboli in small vessels.


Cardiocirculatory responses to exercise: physiologic study by noninvasive techniques.


Ischemic myocardial injury during coronary artery surgery.


Continuous prehospitalization monitoring of cardiac rhythm.


Atrioventricular interaction in isorhythmic dissociation.


A new approach to clinical electrocardiography: the phase plane cardiogram.


Electrocardiographic changes in acute pancreatitis resembling acute myocardial infarction.


Anastomotic coronary vessels in hypoplasia of the right ventricle.


Treatment of familial hypercholesterolemia in children.


A practical technique for superimposition of electrocardiograms on cineangiographic film.


"Pacemaker heart sound" caused by diaphragmatic contractions.


Hemodynamic spectrum of left ventricular failure in experimental myocardial infarction.


Method for correction of the vectorcardiogram for body surface area.


An aid to left heart catheterization.

An aid to left heart catheterization.


Emergency management of failing pacemakers.


Medroxyprogesterone acetate (Provera) in the treatment of metastatic renal cancer. Eighty patients with advanced metastatic renal cancer have been treated with hormones, chiefly medroxyprogesterone acetate (Provera). This progestational compound is remarkably free from side-effects and can be given in high dosage for long periods without serious complications. Ninety per cent of cases had multiple metastases: in 76% more than one organ was involved and nearly 50% were seriously ill or "terminal".Subjective improvement occurred in at least 55%. In 11 patients there was marked improvement in the radiological or clinical signs of tumour within 2 to 6 weeks of commencing treatment or changing to a different hormone. In two further cases improved general health was associated with stationary metastases for 20 months. A significant objective response occurred in 16% of the total series. A favourable response was seen more often in men (21%) than in women (8%). If deaths within 6 weeks are excluded the objective response rate in men is increased to 27%. Although the response of advanced renal cancer to hormonal treatment is usually incomplete and of brief duration, it is possible for such treatment to offer a "new lease of life" to a seriously ill patient, even in old age, for 2 to 3 years.


Endocrine manifestation of pulmonary carcinoma in a Nigerian. Bronchogenic carcinoma is an uncommon neoplasm in the Nigerian. Endocrine manifestations of pulmonary neoplasm are even more uncommon in Nigerians or elsewhere. The association of gonadotrophin activity with an anaplastic carcinoma of the lung in a 25-year-old Nigerian housewife forms the basis for this communication. The successful removal of a left lower lobe neoplasm in the patient who had manifested with menometrorrhagia and abnormal breast lactation was followed by a normal pregnancy and delivery of a normal baby boy within 12 months following the lobectomy.


A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474. An introductory clinical trial of the anti-oestrogenic agent IC146474 in late or recurrent carcinoma of the breast is described.Forty-six patients have been treated, of whom 10 have shown a good response. This is of the same order as that seen with oestrogens and androgens.The particular advantage of this drug is the low incidence of troublesome side effects.


Zinc induction of testicular teratomas in Japanese quail (Coturnix coturnix Japonica) after photoperiodic stimulation of testis. Teratomas have been induced in Japanese quail (Coturnix coturnix Japonica) by intra-testicular injections of 3% zinc chloride solution during a period of testicular growth artificially stimulated by increased photoperiod. These tumours resemble those previously induced by similar methods in domestic fow1 and have histological features in common with spontaneous testicular teratomas in man.


The effect of antiserum fractions on Ehrlich ascites tumour cells. Hyperimmune heterologous serum produced in sheep against mouse Ehrlich ascites tumour cells was absorbed with normal mouse tissue and fractionated by DEAE column chromatography into IgG1 and IgG2 fractions. In vitro cytotoxicity test showed that sheep anti-Ehrlich ascites tumour IgGl fraction was cytotoxic to (51)Cr labelled tumour cells whereas IgG2 had no cytotoxic effect. Pretreatment of the tumour cells with the non-cytotoxic IgG2 fraction slightly inhibited the cytotoxic action of IgG1 in vitro.When EAT cells were coated with either IgG1 or IgG2 by preincubation in vitro before injecting intraperitoneally into mice, both fractions protected the animals against tumour growth. Injection of IgG2 and IgGl fractions separately, one before and the other after the injection of EAT cells, resulted in partial protection only. The difference encountered between the in vitro and in vivo findings could be attributed to the host defence mechanisms involved in the in vivo test system.


Double minute chromatin bodies in a case of ovarian ascitic carcinoma. The paper presents the cytogenetic constitution of an ovarian ascitic carcinoma. Double minute chromatin bodies were seen in all the metaphases; their number was proportional to the number of the cells. Some properties of the double minute chromatin bodies are discussed.


Effect of induced host anaemia on the viability and radiosensitivity of murine malignant cells in vivo. Within 48 hours of the institution of severe phenylhydrazineinduced anaemia in mice bearing ascites tumours or generalised leukaemia, a substantial proportion of the malignant cells disappeared respectively from the peritoneal cavity or infiltrated liver. The results of radiobiological experiments permitting determination of the proportion of viable leukaemia cells which were severely hypoxic and relatively radioresistant in the livers of leukaemic mice, showed that induction of anaemia was associated with a several hundredfold increase in the proportion of such cells. The proportion of hypoxic cells was greatly reduced when the anaemic leukaemic mice were transfused with packed erythrocytes or allowed to breathe oxygen under high pressure. Similar experi - ments with solid sarcomas indicated that a high proportion of the tumour cells were hypoxic in non-anaemic mice breathing air. The hypoxic fraction was not significantly reduced when tumour-bearing mice were made severely anaemic during growth of the tumour and were later transfused. Thus, the hypoxic cells in leukaemic livers and those in solid tumours are markedly different in their capacity for oxygenation following the induction of relative hyperoxaemia.


Epitaph for the M.C.H.C.

Epitaph for the M.C.H.C.


Albumin metabolism in rabbits and rats with transplanted tumours. Albumin distributions and turnover rates have been studied using (131)I labelled tracer material in rabbits with Vx2 carcinoma and rats bearing SP7 fibrosarcoma in comparison with control animals. Albumin concentrations were reduced in the tumour bearing animals but plasma volumes increased as the tumours developed. Relative increases were seen in the extravascular distribution of albumin, due partly to albumin pooling in and around the tumours and possibly also to general increases in capillary permeability. In the rats there was a considerable increase in the catabolic rate of albumin which was not related to urinary protein loss. The tumour bearing rabbits showed evidence both of increased catabolism and of decreased synthesis and the combination of the two effects resulted in a greater lowering of albumin concentration than was seen in the rats. Possible mechanisms for these findings and their significance in human malignant disease are discussed.


Pregnancy, hair loss, and the pill.

Pregnancy, hair loss, and the pill.


Depression from a physical symptom.

Depression from a physical symptom.


Anaesthetics and platelets.

Anaesthetics and platelets.


Effects of anticonvulsant drugs on chromosomes.


Pathogenesis of myasthenia gravis.

Pathogenesis of myasthenia gravis.


Reflux and hernia.

Reflux and hernia.


Liability from experiments.

Liability from experiments.


Effects of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) and its degradation products on progression of L1210 cells through the cell cycle.


Antitumor activity of 5-formamido-1- D-ribofuranosylthioimidazole-4-carboxamide 2',3',5'-triformate in a variety of animal tumors.


Use of first generation transplants of a slow growing solid tumor for the evaluation of new cancer chemotherapeutic agents.


Phase II study of 6 -methylpregn-4-ene-3,11,20-trione (NSC-17256).


Radiation plus 5-fluorouracil (NSC-19893): clinical demonstration of an additive effect in bronchogenic carcinoma.


Dose-schedule studies with hydroxyurea (NSC-32065) in malignant melanoma.


5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388) in the treatment of malignant tumors other than melanoma.


Evaluation of the combination of hexamethylmelamine (NSC-13875) and methotrexate (NSC-740) in carcinoma of the lung.


Care of tuberculosis patients in the 1970's. After the sanatorium, then what?


Phase II study of strepozotocin (NSC-85998) in the treatment of advanced gastrointestinal cancer.


Elevated serum glyceraldehyde phosphate dehydrogenase activity following acute myocardial infarction.


Interruption of the aortic arch with aortico-pulmonary septal defect and intact ventricular septum in a teenage girl.


Left ventricular wall thickness determined by ultrasound in 100 subjects without heart disease.


Bronchospirometry and blood gas studies after unilateral tube breathing.


A symptom connoting many causes and sequels.


Effects of low-flow oxygen on the hemodynamics and left ventricular function in patients with uncomplicated acute myocardial infarction.


Left axis deviation in inferior infarction; vectorcardiographic recognition of concomitant left anterior hemiblock.


The lesser circulation in pulmonary fibrosis secondary to sarcoidosis and its relationship to respiratory function.


The heart in sarcoidosis.

The heart in sarcoidosis.


Calcified paramediastinal mass.

Calcified paramediastinal mass.


Simultaneous tachycardias associated with acute myocardial infarction.


Giant leiomyoma of the esophagus and cardia weighing more than 1,000 grams.


Fatal pulmonary edema and pneumonitis after reexpansion of chronic pneumothorax.


Recurrent ventricular tachycardia; a late complication of mitral valve replacement.


Intracardiac myxoma in siblings.

Intracardiac myxoma in siblings.


Perforation of the aorta as a complication of mediastinal sepsis.


[Respiratory complications in general surgery].


Chromosome studies in 14 patients with disseminated sclerosis.


A chromosome 13q+ in a patient with characteristics of the trisomy 13 syndrome.


Exomphalos in four consecutive pregnancies.


A note on disc-electrophoresis of human haptoglobin in acrylamide gel.


Results of haptoglobin types investigations in Hungary.


Contribution to the PGM 3  polymorphism phenotype frequencies in Prague.


Segmentary and disseminated lesions in multiple hereditary cutaneous leiomyoma.


Plasma lipids in diabetes mellitus.

Plasma lipids in diabetes mellitus.


Conservative surgery in acute massive bleeding peptic ulcers.


Non-essential  15 N retention in an alcoholic with acute kwashiorkor.


Cyto-analysis in suspected cases of cancer of the lung.


Transformation of mouse emnbryo cells by vaccinia virus.


Levels of serum cholesterol among offspring of parents who died of cancer: a comparison with coronary heart disease.


Light and electron microscopy of low and high malignancy sublines of a rat tumor.


Studies on the utilization of asparagine by mouse leukemia cells.


In vitro "spontaneous" neoplastic transformation of mouse fibroblasts in diffusion chambers.


Disorganization of mouse bladder epithelium induced by 2-acetylaminofluorene and 4-ethylsulfonylnaphthalene-1-sulfonamide.


Immune response to Gross virus-induced lymphoma. I. Kinetics of cytotoxic antibody response.


Carcinogenic effects of polycyclic hydrocarbon carcinogen administration to mice during pregnancy on the progeny.


The protovirus hypothesis: speculations on the significance of RNA-directed DNA synthesis for normal development and for carcinogenesis.


Mouse myeloma tumor stem cells: a primary cell culture assay.


Adequate stimulus for tendon organs with observations on mechanics of ankle joint.


Tension and rate of tension development during isometric responses of extraocular muscle.


Identification and properties of motoneurons to fin muscle of the sea lamprey.


Anatomical and physiological studies on muscles of lamprey.


Fast and slow motoneurons to body muscle of the sea lamprey.


Unilateral synthesis of reovirus double-stranded ribonucleic acid by a cell-free replicase system. A large-particle fraction obtained from reovirus-infected L cells contained both replicase and transcriptase activity. The in vitro replicase reaction slowed down soon after initiation, whereas the transcriptase reaction proceeded at an unabated rate. The replicase and transcriptase were both template-bound and could be separated from one another by controlled chymotryptic digestion followed by centrifugation in a CsCl gradient. The transcriptase was recovered as a sharp band (rho = 1.43) and resembled virus core derived from mature virions. In contrast, replicase activity was distributed throughout the gradient, indicating that replicase is associated with structures of various density in CsCl. In subsequent experiments, the replicase product was found to be indistinguishable from the double-stranded ribonucleic acid (RNA) reovirus genome with respect to its buoyant density in cesium-salt gradients and denaturation-annealing characteristics. A "hybridization-competition" experiment in which the replicase product was denatured and annealed in the presence of an excess of plus-RNA indicated that the in vitro replicase reaction proceeded by means of a unilateral synthesis of minus-RNA upon a preexisting plus-RNA template, presumably of single-stranded form.


Day care centers in Europe: a focus on consequences for mental health.


A reinforcement approach to the elimination of a child's school phobia.


Social variables and their effect on psychiatric emergency situations among children.


Innovations in college mental health.

Innovations in college mental health.


An evaluation of parent drug education.

An evaluation of parent drug education.


Coordinated patient care: a consultant's view.


Evaluating the quality of mental health services: criteria for rapid informal judgement.


Who employs the mentally restored and why?


Serum magnesium differences: further evidence for discontinuity between adult and childhood schizophrenia.


Patients' views on relocation.

Patients' views on relocation.


Staff-patient interaction, race and patient behavior on a psychiatric ward.


Teachers look at classroom behavior problems. A survey.


Are volunteers here to stay?

Are volunteers here to stay?


Coordinating a volunteer program.

Coordinating a volunteer program.


Pollution of the psychological environment.


The psychologist and minimal brain dysfunction: ten steps to maximum incompetence.


Pastoral counseling.

Pastoral counseling.


Marital counseling.

Marital counseling.


Principles for mental health provisions in national health insurance. Adopted by the NAMH Board of Directors, June 19, 1971.


Restoration of normal drinking behavior by chlorpropamide in patients with hypodipsia and diabetes insipidus.


Water, creatinine and sodium excretion following circulatory shcok wtih renal failure.


Disordered calcium and phosphorus metabolism during maintenance hemodialysis. Correlation of clinical, roentgenographic and biochemical changes.


Neural, hematologic and bacteriologic effects of nitrofurantoin in renal insufficiency.


Anti-Candida antibodies in patients with acute leukemia. A prospective study.


Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats.


Hypothalamic syndrome with hypernatremia and muscular paralysis.


Renal artery stenosis, pheochromocytoma and erythrocytosis.


Carcinoid of the pancreas.

Carcinoid of the pancreas.


A quality control program for the bacteriology laboratory.


Professions and the public: a crossroad of interests.


Health education curricula based on common competencies.


Diluter modified to specific need for serial dilutions.


Automated blood volume estimates: linearity, accuracy and reproducibility.


A close look at the automated glucose method.


Characteristics of types of sensory integrative dysfunction.


Occupational therapy in community child health.


Haptic perception in preschool children. I. Object recognition.


Occupational therapy in the well community.


Understanding the arthritic hand.

Understanding the arthritic hand.


Organization concepts. I. Components of administration.


Allied health student perceptions of campus environment.


Comments on the counter culture.

Comments on the counter culture.


The Q-T ratio in treadmill stress testing.


Pulmonary edema associated with pulmonary embolism: a clinicopathological study.


Extensive calcification of the tricuspid valve in rheumatic heart disease.


Isolated popliteal artery rupture caused by blunt trauma.


The physiology and diagnosis of the atrial tachyarrhythmias: some recent concepts.


Indication and the results of pharyngeal flap operation.


Factors in the vocational success of hemiplegic patients.


Differential control of muscle segments by quadriplegic patients: an electromyographic procedural investigation.


Effect of repeated periods of ischemia on sensory and motor latencies of median nerve in the hand at different tissue temperatures.


Elongation of rat tail tendon: effect of load and temperature.


Bucket seat for control of decubitus ulcers.


Importance of the sympathetic nervous system in the development of renal hypertension in the rat. 1. Chemical sympathectomy with 6-hydroxydopamine (6-OHDA) prevented the development of renal hypertension in 80% of weanling male rats of the C.F. strain.2. Adult male rats treated with 6-OHDA developed hypertension on bilateral clamping of the renal arteries.3. Demedullation of the adrenal glands followed by 6-OHDA treatment in adult rats prevented the development of hypertension in 75% of them.4. Weanling rats treated with 6-OHDA did not have any measurable catecholamines in their hearts up to 72-78 days after treatment.5. Unlike the weanling rats, the hearts of adult rats (demedullated or with intact medulla) showed significant refilling (40-50%) of catecholamine stores 60 days after 6-OHDA treatment.6. It is concluded that the functional sympathetic nervous system is important in the development of renal hypertension in the rat.


Actions of dexamphetamine and amphetamine-like amines in chickens with brain transections. 1. A method for preparing the encéphale isolé preparation in young fowls is described. Certain important differences were found between electrocortical activity of chicken and mammalian encéphale isolé preparations. Electrocortical effects of excitant sympathomimetic amines and their antagonism were readily quantified because of stable electrocortical activity of the chick encéphale isolé preparation.2. Amphetamine-like excitant amines ((+)- and (-)-amphetamine, alpha-methyltryptamine, tryptamine, beta-phenethylamine, cyclopentamine, beta-tetrahydronaphthylamine and tuaminoheptane) evoked electrocortical desynchronization in chick encéphale isolé preparations, confirming the central origin of these effects. Behavioural changes were also observed.3. The electrocortical response to these amines was antagonized by methysergide, a selective tryptamine antagonist and by a catecholamine, alpha-methylnoradrenaline. Behavioural changes were also antagonized.4. Electrocortical desynchronization to dexamphetamine was prevented by an anterior transection of the brain which separated the telencephalon from the diencephalon. More posterior transections reduced the duration of the electrocortical response to dexamphetamine; intensity of response was either increased or decreased.


Role of the adrenal gland in the leucocytosis caused by bradykinin or cellulose sulphate in the rat. Intravenous injections of bradykinin, cellulose sulphate (a kinin-releasing agent) or adrenaline cause rapid leucocytosis in the rat. The effect of the two former drugs is abolished by adrenalectomy, that of the latter is unaffected by this treatment. Bradykinin and agents capable of releasing it in plasma, may induce leucocytosis via adrenaline released from the adrenal gland.


Effects of methysergide on platelets incubated with reserpine. 1. Platelets were incubated with methysergide and related compounds (2-bromo lysergic acid (BOL), ergotamine and methyl ergotamine) together with reserpine.2. Methysergide inhibited the normal aggregation response of platelets to 5-hydroxytryptamine (5HT) but did not affect the reduction in the 5HT content caused by reserpine, or the uptake of 5HT by the platelets.3. BOL, ergotamine and methyl ergotamine behaved similarly. Methysergide had greater anti5HT potency than BOL, and methyl ergotamine had greater potency than ergotamine.4. The use of platelets as a model for synaptic preparations is discussed.5. The role of 5HT receptor sites on the platelet membrane and the significance of the results for migraine patients treated with methysergide are discussed.


Inhibition of aggregation and plug formation of platelets subjected to ultrasound and tested in the revolving plastic loop.


Renal handling of paraquat.

Renal handling of paraquat.


Metabolic availability of ascorbic acid in female guinea-pigs.


Wy 23205, a new non-steroidal anti-inflammatory agent.


Evidence that bicuculline can both potentiate and antagonize GABA.


Neurally evoked release of noradrenaline from the olfactory bulb.


Effect of atropine on acetylcholine release from cerebral cortical slices stimulated at different frequencies.


Possible role of dopamine-containing neurones in the behavioural effects of cocaine.


Effects of an anticonvulsant, acetazolamide, on the sodium gradient and xylose uptake of cerebral cortex slices.


Atropine sulphate absorption in humans after intramuscular injection of a mixture of the oxime-P2S and atropine.


Electrically evoked release of vasopressin from isolated neurohypophyses in sodium-free media.


Influence of calcium on responses of human isolated uterine tissue to fenfluramine.


Cardio-active amines found in ox spleen extracts.


Effect of dihydroergotamine (DHG) on the capacitance, resistance and precapillary sphincter vessels of denervated cat skeletal muscle.


Augmentation of atropine resistant spasms in plexus-containing guinea-pig longitudinal muscle by ganglionic action of the acetylcholinesterase inhibitor BW 284C51 (1:5 bis (p-allyl-dimethylammonium phenyl)-pentan-3-one dibromide).


Evaluation of neuronal and extraneuronal uptake mechanisms during adrenergic nerve stimulation.


Amine uptake characteristics of the guinea-pig Auerbach plexus.


Adrenoreceptors in the human foetal colon.


Myocardial effects of indoramin hydrochloride, a new hypotensive agent.


Chloride transport and potential across the blood-CSF barrier.


Brain stem multi-unit activity during "relaxation" behavior in the female cat.


Sleep pattern of hippocampectomized cat.


Location and characterization of hydrolytic enzymes of the 3d ventricle lining in the region of the recessus infundibularis of the rat. A study on the function of the ependyma.


The effects of excitatory and inhibitory amino acids on the metabolism of endogenous brain amino acids in the nembutalized mouse.


The effect of cortical undercutting and long-term electrical stimulation on synaptic acetylcholinesterase.


Tubocurarine binding in undercut cerebral cortex and the effect of long-term electrical stimulation.


Changes in the activity of hypothalamic units during sleep at different environmental temperatures.


Autoradiographic analysis of protein synthesis in synaptosomal fractions.


Studies of clinical judgment. I. A critique.


Cultural aspects of transference and countertransference.


The doctor as a community agent.

The doctor as a community agent.


Combined use of Alcoholics anonymous and outpatient psychotherapy.


Grades of chromatid organisation in mitotic and meiotic chromosomes. I. The morphological features.


Grades of chromatid organisation in mitotic and meiotic chromosomes. II. Their interpretation in terms of a master-slave model.


Autoradiographic studies of human chromosomes. 4. Comparison of the end-of-S patterns in lymphocytes and amniotic epithelial cells.


Constitutive heterochromatin in Microtus agrestis: binding of actinomycin-D and transcriptional inactivity.


Alteration of meiotic chromosomal pairing and synaptonemal complexes by cycloheximide.


Drug use among youth in Denmark in the spring of 1968. Studies among school pupils and other young persons under training.


Low dose of gestagen as a contraceptive method. A clinical trial. The effectiveness of megestrol acatate (350 mcg/day) was studied in 194 women over a total of 2048 woman-months of use.  There were 23 pregn ancies, 7 of which could be attributed to patient error, for an adjusted pregnancy rate of 9.4/100 woman-years of use.  Abnormal bleeding was the most dominant side effect (22.2%).  11.8% of the women discontinued the regimen because of unwanted pregnancy, and 8.2% did so because of abnormal bleeding.  The acceptability rate was 73.3%.  Similar results were reported in another trial.


Metabolic studies of deglycyrrhizinised liquorice in two patients with gastric ulcer.


Malignant osteopetrosis in ancient Nubia. A case from the period 350-550 A.D.


Clinical value of serum vitamin B 12  estimation in jaundice.


Gastro-intestinal and biliary biopotentials following various forms of vagotomy.


Lipase and bile salts in the small intestine of the dog. Relation to lipid absorption.


The role of splenectomy in stomach cancer operations.


The surgical significance of complete retrograde obstruction of the colon.


The acceptability of ileostomies.

The acceptability of ileostomies.


A presacral developmental cyst in a man: report of a case.


Survival of patients at Pennsylvania Hospital with hepatic metastases from carcinoma of the colon and rectum.


The absence of ganglion cells in Hirschsprung's disease.


A modification of the Thiersch technic.

A modification of the Thiersch technic.


Evidence for two acid deoxyribonucleases in Tetrahymena.


Pilonidal sinuses of the anal canal: report of a case.


Studies on fruit tissues of Citrus Acida. II. Studies on some of the enzymes of amino acid metabolism in citrus fruit tissue (Citrus acida).


Studies on fruit tissues of Citrus acida. I. Utilization of protein for the respiration in mature fruit tissues of Citrus acida.


Automated differential isoenzyme analysis. II. The fractionation of serum alkaline phosphatases into "liver", "intestinal" and "other" components.


Learning potential and vocational aspirations of retarded adolescents.


An experimental resource room for behavior problem children.


Effects of delay of reinforcement on retarded children's learning.


Comparability of WISC and PPVT scores among young children.


Relationships of socioeconomic background and school performance of partially seeing children.


Adrenal enzymes of catecholamine biosynthesis and metabolism in spontaneously hypertensive rats.


On the nature of Biological Clocks?

On the nature of Biological Clocks?


Liver and uterine lipid metabolism: a comparative study.


Isolation of cadmium-binding proteins.

Isolation of cadmium-binding proteins.


Persistent circadian rhythmicity of protein synthesis in the liver of starved rats.


The oxygen uptake of the developing brain in the rat with intra-uterine growth retardation.


Influence of various intracranial pressure levels on the concentration of certain arylethylamines in rabbit brain.


Electrolyte transport in the seminiferous tubules of the rat studied by the stopped-flow microperfusion technique.


'Compensatory' muscle hypertrophy in the rat induced by tenotomy of synergistic muscles.


Activation of rat stomach histidine decarboxylase after inhibition of acid secretion with 2-phenyl-2-(2-pyridyl)-thioacetamide (SC-15396).


Protective effect of flavonoids on the collagen of lathyritic rats.


L-DOPA treatment in Parkinson's disease: effect on dopamine and related substances in discrete brain regions.


Additive and synergistic inhibition of mammalian microsomal enzyme functions by piperonyl butoxide, safrole and other methylenedioxyphenyl derivatives.


Censored distribution techniques in analysis of toxicological data.


Fluorescing valvular nerves in the guinea-pig heart.


Ethyl- -p-chlorophenoxyisobutyrate induced hepatic microbody proliferation in rat liver and ubiquinone concentration.


The target period during fetal life for the production of tellurium hydrocephalus.


Effect of fatty acids on fetal rat bone in culture.


Ultrastructural changes in rat liver cells after intramuscular implantation of a Walker tumor.


Amniotic fluid volume in experimentally induced renal agenesis and anencephaly.


Catecholamine-containing nerves in the submucosa of the ureter.


Interpretation of the methylene blue reduction test of human plasma and the possible cancer protecting effect of selenium.


Electron microscopical evidence for innervation of chief cells in human parathyroid gland.


Hematopoietic alterations produced by long-term treatment with phytohemagglutinin.


Cytophotometric studies of the course of the S phase in PHA stimulated lymphocytes.


Testosterone metabolism by mouse placenta in vitro.


Varying degrees of ventromedial hypothalamic destruction in the weanling rat and its effect on plasma triglyceride and cholesterol levels.


The threshold osmotic reactivity of the hypothalamo-hypophyseal antidiuretic system and of the thirst mechanism.


Random X-chromosome inactivation in interspecific hybrids of Meriones libycus (male) x Meriones shawi (female) (Rodentia: Gerbillinae).


Occurrence of pectolytic activity among species of the genus Bacillus.


Antimalarial activity of natural, racemic and unnatural dihydroquinine, dihydroquinidine and their various racemic analogs in mice infected with Plasmodium berghei.


Nursing workload  in geriatric unit.

Nursing workload  in geriatric unit.


New aspects on the storage of 5-hydroxytryptamine in blood platelets.


Weight loss and lipid changes in overweight subjects.


Clinical outlook for stroke patients.

Clinical outlook for stroke patients.


Fracture of the femur as a presentation of osteomalacia.


Physical, mental and social assessment of elderly patients suffering from cerebrovascular accident with special reference to rehabilitation.


Dietary potassium intake and grip strength in older people.


Studies relating mastication and nutrition in the elderly.


Changes in sodium, potassium and body fluid spaces in depression and dementia.


Serum iron levels and haematological status in the elderly.


Growth hormone and insulin in severe infantile malnutrition. I. Plasma growth hormone response to hypoglycemia.


Growth hormone and insulin in severe infantile malnutrition. II. Plasma insulin and growth hormone during intravenous glucose tolerance test.


Bloom's syndrome. Case report.

Bloom's syndrome. Case report.


Observations on the electrocardiogram in Duchenne's progressive muscular dystrophy.


President's report to members.

President's report to members.


Eating and aging.

Eating and aging.


Comparative group approaches.

Comparative group approaches.


Acral fibrokeratoma.

Acral fibrokeratoma.


Frequency of feeding, weight reduction, and body composition.


Frequency of feeding, weight reduction, and nutrient utilization.


Phototherapy for hyperbilirubinemia.

Phototherapy for hyperbilirubinemia.


Sucrose solution vs. no-calorie sweetener vs. water in weight gain.


Treatment of chromomycosis with 5-Fluorocytosine.


The nutritionist in the university-affiliated center.


Sunlight protection in patients with Chlorpromazine light sensitivity.


Treatment of mucocutaneous (American) leishmaniasis with amphotericin B: report of 70 cases.


Serum IGE levels in cutaneous Larva Migrans.


Urea cream for dry skin.

Urea cream for dry skin.


The place of appliance and allied work in private practice.


Dysplasia epiphysealis hemimelica of the talus. A case study.


A comparison of the effects of reflex heat to local heat in patients with mild to moderate peripheral vascular disease.


Foot concerns in the aging process.

Foot concerns in the aging process.


Tryptamines. I. The chromatography of melatonin.


Gas chromatographic determination of doxepin in human urine following therapeutic doses.


The analysis of aspirin and related compounds by liquid chromatography.


Determination of chlordiazepoxide plasma concentrations by electron capture gas-liquid chromatography.


Free fatty acid phase high resolution capillary columns.


Thin-layer chromatography of red cell glycosphingolipids from various mammalian species.


Gas chromatography of ergot alkaloids.

Gas chromatography of ergot alkaloids.


The analysis of oils and fats by gas chromatography. IX. Separation factors of non-methylene-interrupted polyolefinic esters.


Separation and quantitative analysis of some benzomorphane derivatives by thin-layer chromatography.


Color detection of bile acids in thin-layer chromatography.


Thin-layer chromatographic separation of 14C-labelled branched-chain alpha-keto acids and hydroxamic acids derived from the corresponding enzymatically formed acyl-CoA compounds.


Separation of sugars from untreated urine.


Heterogeneity of protein fractions isolated by preparative electrophoresis of human saliva.


The formation and metabolism of 3 ,7 -dihydroxy-5 -cholestan-26-oic acid in man. The formation and metabolism of a naturally occurring C(27) bile acid, 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid, was studied in patients with T-tube bile fistulas. C-26-cholesterol-(14)C was shown to be converted to this C(27) bile acid. After synthesis and labeling with tritium, 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid was efficiently metabolized to chenodeoxycholic acid. After oral and i.v. administration there was conversion of about 80% of the administered amount to chenodeoxycholic acid. A small amount, less than 2% of the administered radioactivity, was converted to cholic acid. The remainder of the radioactivity was excreted in two unidentified peaks of radioactivity. The results of this study demonstrate that 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid is a metabolic product of cholesterol and is further metabolized, predominantly to chenodeoxycholic acid and to a minor extent to cholic acid in man.


Synthesis and transport of lipoprotein particles by intestinal absorptive cells in man. The site of synthesis and some new details of lipoprotein particle transport have been demonstrated within the jejunal mucosa of man. In normal fasting volunteers, lipoprotein particles (88%, 150-650 A diameter) were visualized within the smooth endoplasmic reticulum and Golgi cisternae of absorptive cells covering the tips of jejunal villi. Electron microscopic observations suggested that these particles exited through the sides and bases of absorptive cells by reverse pinocytosis and then passed through the extracellular matrix of the lamina propria to enter lacteal lumina. When these lipid particles were isolated from fasting intestinal biopsies by preparative ultracentrifugation, their size distribution was similar to that of very low density (S(f) 20-400) lipoprotein (VLDL) particles in plasma. After a fatty meal, jejunal absorptive cells and extracts of their homogenates contained lipid particles of VLDL-size as well as chylomicrons of various sizes. The percentage of triglyceride in isolated intestinal lipid particles increased during fat absorption. Our interpretation of these data is that chylomicrons are probably derived from intestinal lipoprotein particles by addition of triglyceride.


Serum alkaline phosphatase in hypophosphatasia. It is recognized that serum alkaline phosphatase may reflect enzyme contributions from bone, liver, and intestine. We have investigated serum alkaline phosphatases in two siblings with hypophosphatasia. After administration of long-chain triglycerides, the major alkaline phosphatase component of their sera was shown to be of intestinal origin on the basis of inhibition by l-phenylalanine. Starch block electrophoresis suggested that there were other regions of l-phenylalanine-sensitive alkaline phosphatase in addition to the major slow-moving intestinal band. Medium-chain triglycerides which are absorbed by the portal route did not cause a similar augmentation of intestinal alkaline phosphatase activity. These studies indicate that serum levels of intestinal alkaline phosphatase are increased normally after long-chain fat feeding in hypophosphatasia and may be the major component of total serum alkaline phosphatase activity.


Secretion of glucagon from the isolated, perfused canine pancreas. Using the isolated, perfused canine pancreas preparation, previously described, the interrelationship of the secretion of pancreatic glucagon and insulin was studied after stimulation with glucose, gastrointestinal hormones, and the amino acid arginine. The results confirm the concept that pancreatic glucagon is a hormone of "glucose need" and suggest that it may be important in a moment to moment control of glucoregulation. The secretion of pancreatic glucagon was stimulated after infusion of gastrin, pancreozymin, and arginine, while no increase was associated with secretin infusion. The magnitude of the increase was closely related to the glucose concentration present in the perfusion medium, being higher and more pronounced during perfusion with low concentrations of glucose (25 mg/100 ml or 50 mg/100 ml). Stimulation of insulin secretion was seen after glucose, gastrin, pancreozymin, secretin, and arginine. The magnitude of the increase was again closely related to the glucose concentration present, this time being higher and more pronounced during perfusion with high glucose concentrations (150 mg/100 ml). Secretion of both pancreatic hormones always followed a biphasic response pattern after the stimuli mentioned, similar to the characteristic release pattern previously described for insulin after an increment in glucose concentration. In order to elucidate whether endogenous pancreatic glucagon possesses an insulinogenic action, as it has been shown to be the case with the administration of exogenous pancreatic glucagon, the time interrelationship of the secretion of pancreatic glucagon and insulin was investigated by determining the initial rise of the hormones after stimulation with gastrin, pancreozymin, and arginine. The rise of glucagon and insulin occurred simultaneously, i.e. inside a 10 sec period. This does not, however, exclude with certainty an insulinogenic role of pancreatic glucagon.


Performance of the right ventricle under stress: relation to right coronary flow. Right ventricular performance was studied relative to right coronary artery flow in the chloralose-anesthetized, open chest dog. The right coronary artery was cannulated for measurement and control of flow and pressure. Under control conditions, right coronary artery occlusion caused no change in cardiac output, or right and left ventricular pressures, although right ventricular contractile force fell markedly. With right coronary artery flow intact, incremental pulmonary artery obstruction caused a corresponding decline in cardiac output and elevation of right ventricular end-diastolic pressure with eventual total right ventricular failure and systemic shock. With right coronary artery occlusion, identical degrees of pulmonary artery obstruction resulted in more pronounced changes in cardiac output and right ventricular end-diastolic pressure with right ventricular failure occurring at a much lower level of right ventricular stress.However, with right coronary artery flow intact, the right ventricular decompensation induced by pulmonary artery obstruction, could be reversed by raising right coronary artery perfusion to levels above normal, thus increasing right ventricular performance and restoring cardiac output. We conclude that right ventricular failure and resultant systemic hypotension due to severe pulmonary artery obstruction can be reversed simply by right coronary artery hyperperfusion, and that, although a normally contractile right ventricular free wall is not essential to maintain cardiac performance at rest, during right ventricular systolic stress, over-all cardiac performance becomes increasingly dependent on the right ventricle. The data further imply that increased myocardial impingement on right coronary artery flow during systole in right ventricular hypertension may be an important factor leading to right ventricular failure.


Proximal tubular function in dogs with thoracic caval constriction. The effect of saline infusion on proximal sodium reabsorption was compared in normal dogs and in dogs with acute or chronic partial thoracic vena cava obstruction. After acute vena cava obstruction, proximal fractional sodium reabsorption rose by 74%. During continued caval obstruction, saline loading strikingly reduced proximal reabsorption but sodium excretion remained minimal. In chronic caval dogs, saline loading reduced proximal fractional sodium reabsorption by 31% but sodium excretion in the micropunctured kidney was only 41 muEq/min. After saline infusion in normal dogs, proximal fractional sodium reabsorption fell 39% while unilateral sodium excretion rose to 584 muEq/min. Nephron filtration rate was also measured before and after saline loading in normal and chronic caval dogs in both repunctured and fresh tubules. There was a marked increase in nephron filtration rate in repunctured tubules and no change in freshly punctured tubules in both groups. The effect of saline loading on nephron filtration rate in normal and chronic caval dogs was similar, therefore, whether repunctured or fresh nephrons were considered.We conclude that saline infusion depresses proximal sodium reabsorption in acute and chronic TVC dogs. Since saline loading markedly increases distal delivery without a concomitant natriuresis, enhanced distal reabsorption must play a major role in the sodium retention exhibited by chronic caval dogs. Redistribution of filtrate does not appear to be a factor in this sodium retention.


A decreased metabolic clearance rate of aldosterone in benign essential hypertension. Aldosterone secretion rate, metabolic clearance rate, and/or plasma concentration were determined in 16 patients with benign, uncomplicated essential hypertension and compared with those of control subjects. The mean metabolic clearance rate of aldosterone in 10 patients was significantly (P < 0.001) lower (mean 867 liters of plasma/day per m(2) +/-270 SD) than in a group of 7 healthy subjects (mean 1480 liters/day per m(2) +/-265 SD). Secretion rates in 13 patients (including the 10 already mentioned) tended to be low (83 +/-43 vs. 109 +/-54 mug/day) and plasma concentrations tended to be high (13.6 +/-4.6 vs. 7.5 +/-4.8 ng/100 ml), but neither of these differences was statistically significant. The lower metabolic clearance rate could account for elevated plasma concentrations of aldosterone even when the secretion rate is normal or low. Measurement of secretion rate or urinary excretion only is therefore insufficient to establish the presence and/or mode of evolution of hyperaldosteronism. Failure of the aldosterone secretion to adapt fully to a decreased aldosterone metabolic clearance rate (MCR) could explain the state of relative hyperaldosteronism in patients with benign essential hypertension, even when the secretion rate and the urinary excretion rate are in the normal range.


The effect of alanine on glucagon secretion. If glucagon plays a hormonal role in the regulation of gluconeogenesis from endogenous amino acids, its secretion might be stimulated by an increase in the concentration of alanine, which has recently been identified as a principal gluconeogenic precursor. To determine if this is the case, 0.75 mmole of alanine per kilo was infused into conscious dogs immediately after a priming injection of 0.25 mmole per kg for 15 min. A uniform rise in the plasma level of pancreatic glucagon, as determined by a relatively specific radioimmunoassay for pancreatic glucagon, was observed. The rise, which averaged 90 pg per ml, was highly significant at 7(1/2) and 15 min after the start of the infusion. Insulin rose an average of only 8 muU per ml, while glucose rose an average of 10 mg per 100 ml. A lower dose of alanine, 1 mmole per kg, infused over a 1 hr period without an initial priming injection, also elicited a significant rise in glucagon measured in the pancreaticoduodenal venous plasma; glucagon rose from 350 pg per ml to 1066 pg per ml at the end of the infusion. The insulin response was modest and inconsistent, and glucose, again, rose 10 mg per 100 ml. To determine if the availability of exogenous glucose would abolish the alanine-induced rise in glucagon secretion, dogs were made hyperglycemic by a constant intravenous glucose infusion and were then given the high-dose alanine infusion. Under these circumstances, glucagon did not rise above the mean fasting concentration of 75 pg per ml, whereas mean insulin rose dramatically by more than 100 muU per ml. It was concluded that, in the fasting state, alanine does stimulate the secretion of glucagon, while having very little stimulatory effect on insulin secretion. Glucagon could, therefore, be a humoral mediator of gluconeogenesis from endogenous alanine, responding to hyperalaninemia in the fasting state, but not when exogenous glucose is available.


The relative contributions of reabsorptive rate and redistributed nephron filtration rate to changes in proximal tubular fractional reabsorption during acute saline infusion and aortic constriction in the rat. The absolute rate of reabsorption by superficial rat proximal tubules was measured by the in situ microperfusion technique under conditions of hydropenia, infusion of saline, and infusion of saline plus aortic constriction sufficient to decrease whole kidney filtration rate below hydropenic levels. Fractional reabsorption was measured in adjacent filtering nephrons by collecting and recollecting tubular fluid from late proximal convolutions during each experimental condition. During hydropenia, the absolute rate of proximal tubular reabsorption averaged 3.56 +/-0.60 nl/min per mm and late proximal tubular fractional reabsorption averaged 0.56 +/-0.10. From these two measurements and measurements of tubule length to the site of micropuncture, a value for filtration rate was calculated for filtering nephrons. During hydropenia this value averaged 32.9 +/-7.1 nl/min. Saline infusion increased sodium excretion to 5.5% of the filtered load as the absolute rate of proximal tubular reabsorption decreased 38% and fractional reabsorption decreased 45%. Calculated superficial nephron filtration rate increased 21% which on the average was identical with the simultaneously measured increase in whole kidney filtration rate. Similar results were obtained in a separate group of animals by the technique of total collection of late proximal tubular fluid. Aortic constriction during saline infusion decreased whole kidney and calculated nephron filtration rate to the same degree and to values lower than those during hydropenia. Fractional reabsorption increased but not to hydropenic values. The persistent natriuresis during aortic constriction was associated with a continued depression of the absolute rate of proximal tubular reabsorption which was sufficient to maintain an increased delivery of filtrate out of the proximal tubule despite the fall in nephron filtration rate. These results indicate that depressed fractional reabsorption in the proximal tubule during acute saline infusion is due predominantly to a decrease in absolute reabsorptive rate and to a lesser extent to an increase in superficial nephron filtration rate which is proportional to the increase in whole kidney filtration. Continued natriuresis when filtration rate is decreased during saline infusion can be accounted for entirely by the persistent large reduction in the absolute rate of proximal tubular reabsorption.


Hydrogen peroxide utilization in myeloperoxidase-deficient leukocytes: a possible microbicidal control mechanism. Phagocytosis-induced formate and glucose C-1 oxidation by the polymorphonuclear leukocytes of a patient with hereditary myeloperoxidase deficiency was considerably greater than normal. The addition of catalase to the leukocyte suspension was required for optimum formate oxidation. Azide and cyanide increased glucose C-1 oxidation by normal leukocytes but had little or no effect on myeloperoxidase-deficient leukocytes suggesting that these agents normally stimulate glucose C-1 oxidation, in part, by inhibition of myeloperoxidase. It is suggested that the inhibition or absence of myeloperoxidase results in an increased utilization of H(2)O(2) in nonmyeloperoxidase-mediated H(2)O(2)-dependent reactions such as formate oxidation and hexose monophosphate pathway activation. The possibility of a microbicidal control mechanism in which a decrease in the microbicidal activity of myeloperoxidase is offset, in part, by an increase in the nonenzymatic microbicidal activity of H(2)O(2) is considered.


Effective glomerular filtration pressure and single nephron filtration rate during hydropenia, elevated ureteral pressure, and acute volume expansion with isotonic saline. Free-flow and stop-flow intratubular pressures were measured in rats with an improved Gertz technique using Landis micropipets or a Kulite microtransducer. In hydropenia, average single nephron glomerular filtration rate was 29.3 nl/min, glomerular hydrostatic pressure (stop-flow pressure + plasma colloid osmotic pressure) was 70 cm H(2)O and mean glomerular effective filtration pressure was 12.7-14.3 cm H(2)O, approaching zero at the efferent end of the glomerulus. Thus, the glomerulus is extremely permeable, having a filtration coefficient four to five times greater than previously estimated. Mean effective filtration pressure and single nephron glomerular filtartion rate fell with elevated ureteral pressure and rose with volume expansion, more or less proportionately. Changes in effective filtration pressure were due primarily to increased intratubular pressure in ureteral obstruction and to reduced plasma colloid osmotic pressure in volume expansion; glomerular hydrostatic pressure remained constant in both conditions and thus played no role in regulation of filtration rate.


Family practice in rural areas.

Family practice in rural areas.


Monoamines in the carotid body cells of the cat.


Review of 36 cases with extra-cranial arterial occlusion.


Accidental haemorrhage. The present position.


Puerperal anaemia in mid-west Ireland.

Puerperal anaemia in mid-west Ireland.


Pre-hospital coronary care.

Pre-hospital coronary care.


An initial analysis. U. of S. A. Medical College Dean reports on early progress.


Hill-Burton in Alabama--25 years later.

Hill-Burton in Alabama--25 years later.


The negative tuberculin test.

The negative tuberculin test.


A rationale for tuberculosis control.

A rationale for tuberculosis control.


Epidemiology of TB infection.

Epidemiology of TB infection.


MIST brings free consultation to all Alabama doctors.


Tumor inhibitors. 69. Structure-cytotoxicity relationships among the sesquiterpene lactones.


Structure and tumor-promoting activity of anthralin (1,8-dihydroxy-9-anthrone) and related compounds.


Nucleic acids. 11. Synthesis of 5'-esters of 1-beta-D-arabinofuranosylcytosine possessing antileukemic and immunosuppressive activity.


Antimalarial agents. 8. Ring-substituted bis(4-aminophenyl) sulfones and their precursors.


Synthesis and antiinflammatory activity of some 3-carboxamides of 2-alkyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide.


Metabolism of [14C]verapamil.

Metabolism of [14C]verapamil.


17-Alpha-propadienyl-19-nortestosterone and related compounds. A new series of potent orally active progestogens.


Potential antifertility agents. 1. Substituted diaryl derivatives of benzo[b]thiophenes, benzo[b]furans, 1H-2-benzothiapyrans, and 2H-1-benzothiapyrans.


Synthesis and hormonal activities of 8-L-homolysine-vasopressin.


1-Trifluoromethyl-1,2,2-triphenylethylenes. Synthesis and postcoital antifertility activity. The synthesis of a series of triphenylethlenes with CF(3) groups placed directly on the ethylene carbon is described, and the postcoital and uterotropic activities of these 1-trifluoromethyl-1,2,2-triphenylethylenes are determined. The parent  compound and 3 substituted analogs were prepared by the stepwise replacement of the vinylic F atoms of hexafluoropropene with aryl groups from ArLi reagents. The postcoital antifertility and uterotrophic activities in the rat were determined  by treating rats with induced precocious puberty with the synthesized compounds for 6 days after mating occurred. The most potent compound of this series was trans-p-methyoxy-alpha-phenyl-alpha'-(trifluoromethyl) stilbene.


Thyroxine analogs. 21. o- and m-L-Thyroxine and related compounds.


Structure-activity relationships having a basis in regular solution theory.


Further evaluation of N,N'-polymethylene-bridged 2-aminoethanethiol derivatives and related compounds as radioprotective agents.


Potential antimalarials. 6. Some 2-phenyl-6- and-8-quinolinemethanols and 8-phenyl-4-quinolinemethanols.


Potential antimalarials. 7. Tribromomethylquinolines and positive halogen compounds.


Synthesis of some adamantane derivatives of 2-aminobenzothiazoles.


Synthesis, transformation, and general pharmacologic activity in 1,4-benzodiazepine-3,5-diones.


Synthesis and norepinephrine-depleting activity of some esters of metaraminol.


Antispasmodic agents. 2. Syntheses and pharmacological activity of ethyl 2-(omega-amino-alkyl)-2-(3-methoxyphenyl)phenylacetates.


Studies on the cholinergic receptor. 6. Synthesis and muscarinic activity of 2-methyl-4-(2-dimethylaminoethyl)-1,3-dioxolane methiodide.


Potential folic acid antagonists. 5. Synthesis and dihydrofolate reductase inhibitory activities of 2-amino-4,6-substituted-5-arylazopyrimidines.


Antigenic polypeptides. Synthesis and immunochemical studies of poly(L-phenylalanyl-L-glutamyl-L-alanylglycyl)-glycine-1-14C ethyl ester.


Synthesis of thiocarbamate S-ester derivatives.


Synthesis and reactions of some pyrrolidinediones.


Potential folic acid antagonists. 6. Potential irreversible folate reductase inhibitors derived from 2,4-diamino-5-arylazopyrimidines.


Pyrazoles. 4. Analogs of 3-(3,3-dimethyl-1-triazeno)pyrazole-4-carboxamide.


Steroidal heterocycles. 14. 1,8a-Epoxy-1,4,4a,5,6,7,8,8a-octahydro-2-hydroxynaphthalene-3-carbonitrile and related compounds.


A-Norandrogens.

A-Norandrogens.


A new group of enterobacteria, possibly a new Citrobacter sp.


The digestive capacity of pyridoxine-deficient phagocytes in vitro.


Sarcina ventriculi in human faeces.

Sarcina ventriculi in human faeces.


Endocarditis caused by a Coprinus species: a fungus of the toadstool group.


Lysozyme production by staphylococci and micrococci.


Phospholipid splitting and metabolic stimulation in polymorphonuclear leukocytes.


Characterization of lymphocytes in calf thoracic duct lymph.


The cellular composition of an acute inflammatory exudate in rats.


Renal emphysema.

Renal emphysema.


Urologic aspects of Hippel-Lindau syndrome.


Free supernumerary kidney: report of a case.


Iatrogenic lesions in serial renal biopsy samples.


Use of a modified Menghini needle for renal biopsy.


Active lupus glomerulitis and hematoxylin bodies with normal urinalysis.


Xanthogranulomatous pyelonephritis: an unusual case.


Partial nephrectomy in bilateral renal carcinoma: discussion and case report.


Carcinoma of the kidney producing multiple hormones.


Antibiotic nephrotoxicity: a cause of persistent bilateral nephrogram.


Non-traumatic perirenal hematoma: the value of arteriography in diagnosis.


Anterolateral deviation of ureters by psoas muscle hypertrophy.


An experimental study of the circulation relative to surgery of the intramural and intravesical ureter.


The ultrasonic treatment of Peyronie's disease.


Primary retroperitoneal seminoma without gonadal involvement: a report of 3 cases.


Hereditary and familial vesicoureteral reflux.


Permanent cystostomy with a plug: preliminary report.


Eosinophilic cystitis.

Eosinophilic cystitis.


Endometriosis of the bladder in a male patient.


Vesicocorporeal fistula with menouria.

Vesicocorporeal fistula with menouria.


Vaginal vesicostomy for empyema of the defunctionalized bladder.


The air cystometer: a new instrument for evaluating bladder function.


Congenital curvature of the penis.

Congenital curvature of the penis.


Urinary incontinence: a challenge and a solution. II. Experience with a new operation: vesiconeosphinctroplasty.


Liposarcoma of the spermatic cord: report of a case and review of the literature.


Response of acute epididymitis to oxyphenbutazone.


Endometrial carcinoma of uterus masculinus (prostatic utricle). Report of 6 cases.


Malignant neurolemmoma of prostate gland.


Radiotherapy of carcinoma of the prostate: preliminary report.


Principles of treatment of persistent post-prostatectomy hemorrhage.


Use of hemostatic bag after transurethral prostatic resection.


Voiding patterns in young healthy women.


Effect of testosterone therapy on some of the constituents of human seminal plasma.


Glass foreign object in the kidney.

Glass foreign object in the kidney.


Cystic kidneys in children with congenital urethral obstruction.


Effect of vesicoureteral reflux on concentrating ability.


Rapid thin layer chromatography of clinically important sugars.


Genetic factors and personality disorders.


Studies of enuresis. I. Incidence of obstructive lesions and pathophysiology of enuresis.


The solubility test for Hb S: a cheap and rapid method.


Rapid determination of serum diphenylhydantoin by gas chromatography.


The disc sensitivity test.

The disc sensitivity test.


A digital polarograph for the evaluation of membrane PO2 electrodes.


A dust collecting apparatus of simple construction.


The conversion of haemoglobin to cyanmethaemoglobin.


Malignant melanoma developing in intrauterine life.


Pick-Herxheimer's acrodermatitis chronica atrophicans with sclerodermiform and anetodermal lesions; IgM paraproteinaemia.


On a case of uretero-calyceal anastomosis.


Air peridurography in lumbar disk hernia.


The correlative value of thermometry and the glucose tolerance test in cancer of the breast.


On the topochemistry of dihydrofolate reductase.


Attitudes toward racial integration.

Attitudes toward racial integration.


Multistability in perception.

Multistability in perception.


Regeneration of the locally irradiated bone marrow in polycythemic rats.


Effect of cis-dichlorodiamine platinum (II) on the post-irradiation lethality in mice after irradiation with X-rays.