Heavy-particle treatment of Cushing's disease.


Excretion of S-adenosylmethionine and S-adenosylhomocysteine in homocystinuria.


Adenocarcinoma of the vagina and stilbestrol as a "morning-after" pill.


Oxyphenisatin and chronic active hepatitis.


Ethanol, osmolality, and rational chemical units.


Genetic counseling for sickle-cell-disease carriers.


Jogging in Tasmania.

Jogging in Tasmania.


An infected toe.

An infected toe.


Critical appraisal of Soviet medicine.

Critical appraisal of Soviet medicine.


Effects of low concentrations of asbestos. Clinical, environmental, radiologic and epidemiologic observations in shipyard pipe coverers and controls.


The crescendo presystolic murmur of mitral stenosis with atrial fibrillation.


Medical care as a right: a refutation.

Medical care as a right: a refutation.


Medical ethics--malpractice and the conscience of the practitioner.


Action on asbestos.

Action on asbestos.


One price of acrophilia.

One price of acrophilia.


Pathogenesis of leukemia.

Pathogenesis of leukemia.


Phosphates and red-cell glycolysis.

Phosphates and red-cell glycolysis.


Post-transfusion hepatitis rate unknown.


Thrombophlebitic prodrome in hepatitis.

Thrombophlebitic prodrome in hepatitis.


Injury and permeability of gastric mucosa.


Esophageal rupture after mushroom-alcohol ingestion.


Ammonia in fibrin hydrolysates.

Ammonia in fibrin hydrolysates.


Glucagon and propranolol (Inderal) toxicity.


Manic behavior and levodopa.

Manic behavior and levodopa.


Another reaction to aminophylline.

Another reaction to aminophylline.


Massachusetts "generic drug law".

Massachusetts "generic drug law".


Japanese not hypersensitive to warfarin.


Energy loss in fluid therapy.

Energy loss in fluid therapy.


Old and new fashioned medicine.

Old and new fashioned medicine.


Kaplan D:Helping the sick poor at Dorado Beach.


Final advice to women MD's.

Final advice to women MD's.


Photoreactivation of killing in Streptomyces. 3. Action spectra for photolysis of pyrimidine dimers and adducts in S. griseus and S. griseus PHR-1.


The regulation of body-weight in man.

The regulation of body-weight in man.


Behavioural factors in the regulation of food intake.


Nutrition after injury.

Nutrition after injury.


Metabolism after surgery in the elderly.


Report on nutrition education in medical faculties. Recommended by the International Union of Nutritional Sciences Committee (V-1) on nutrition education in Medical Faculties.


Influence of the size of the fraction dose on normal and tumour tissue in  60 Co radiation treatment of carcinoma of the larynx and inoperable carcinoma of the breast.


Brain damage after x-ray therapy. Report of a case.


Testosterone as a bone marrow stimulant in irriadiated rats.


The influence of the dose per fraction on radiation damage to the myelum.


Effect of pentagastrin on pancreatic secretion in man.


Selective vagotomy of the gastric remnant for extragastric ulcer recurrence following resection.


Truncal vagotomy and drainage in 500 patients with duodenal ulcer.


Epidemiology of ulcerative colitis and regional enterocolitis (Crohn's disease) in Norway.


Salivary expression of taste response to chemical stimulation.


Uptake of rat gastric-juice-bound vitamin B 12  by intestinal brush borders isolated from blind-loop rats.


Micellar solubilization of intestinal lipids and sterols in gluten enteropathy and liver cirrhosis.


Blind-loop reflux in relation to weight loss in obese patients treated with jejunoileal anastomosis.


Bile salt, fat, water, and vitamin B 12  excretion after ileostomy.


Influence of selective hepatic vascular perfusion on ammonia metabolism in dog.


Radiography in the diagnosis of recurrent duodenal ulceration following vagotomy and pyloroplasty.


Gastric secretion of calcium and inorganic phosphorus in patients with primary hyperparathyreoidism.


Spontaneous oesophageal rupture. An evaluation of the results of treatment 1944-1969.


Traumatic perforations of the oesophagus.


The reaction of collateral arteries to an atherogenic diet.


The peripheral lung pulse and bronchial circulation.


Isolated pulmonary valve stenosis. A follow-up study.


Disc wear in the Björk-Shiley tilting disc valve. Experimental and clinical observations.


The disc rotation in patients operated upon with the Björk-Shiley tilting disc valves with radiopaque markers.


Investigations of operability in cases of bronchial carcinoma. Evaluation of 515 patients.


Current status of the epidemiology of brain infarction associated with occlusive arterial disease.


The brain in hereditary hemorrhagic telangiectasia.


The role of socioeconomic factors in cerebral atherosclerosis.


Comparison of anticoagulation and surgical treatments of TIA. A review and consolidation of recent natural history and treatment studies.


Clinical prognosis correlated with hemispheric blood flow in cerebral infarction.


Improvement in motor performance in paretic and paralyzed extremities following nonembolic cerebral infarction.


Cerebral atherosclerosis in Japanese. I. Age related to atherosclerosis.


Transplantation of tooth buds across a multiple non-H-2 barrier.


Lymphocyte reactivity in vitro. VII. The effect of polymorphonuclear leukocytes on lymphocyte response.


Blastogenic responses of human lymphocytes to xenogeneic cells in vitro.


Synergism in immunosuppression. II. Effect of splenectomy on suppression of tetanus antitoxin production induced by methylprednisolone, azathioprine, chlorambucil, and radiation.


Leucocytotoxic antibodies and preeclamptic toxaemia of pregnancy.


Effect of adult thymectomy and antilymphocyte globulin treatment on metastases in an allogeneic mouse tumor system.


Thymectomy in the adult mouse.

Thymectomy in the adult mouse.


Therapeutic experience with chlorimipramine injections.


The effects of antidepressant therapy. A follow-up study.


Clinical experience with prophylactic lithium therapy of manic depressive psychoses.


Modification of depressive episodes during prophylactic administration of lithium salts.


Clinical experience with fluspirilene in psychoses.


Clinicl experience with flupenthixol in the treatment of chronic schizophrenia.


Relationship between the therapeutic effect and side-effects in the treatment with antidepressive drugs.


Clinical experience with clothiapin (Entumin) in schizophrenic psychoses.


Pharmacological properties of a new potential neuroleptic drug oxyprothepin. II. Influence on behaviour in rats.


Therapeutic effect of fluphenazin in various doses and forms.


A contribution to the problems of placebo dependence: case report.


Pharmacological properties of a new potential neuroleptic drug oxyprothepin. 3. Electroencephalographic study in rabbits.


Pharmacological properties of a new potential neuroleptic drug oxyprothepin. IV. Antiadrenergic action and influence on brain monoamines.


Peripheral effects of anticholinergic psychotomimetics.


JB 336 effect on the central adrenergic system.


Central anticholinergic activity of JB 336.


On the interaction of scopolamine and physostigmine in man.


The influence of clomethiazol (Heminevrine) on acute ethanol intoxication in abstaining alcoholics. (An experimental study).


The influence of anticholinergic hallucinogens on spontaneous and conditioned behaviour in rats.


The effect of pyrithioxine (Encephabol) on behaviour of rats, malnourished in early life.


Acute effect of dimethacrine (50 mg), mefaxamide (200 mg), and dixyrazine (25 mg) on higher nervous activity in mn.


Induction of dominant lethals and translocations in mice by LSD.


Dissociation between EEG and spontaneous behaviour of rats after atropine.


EEC frequency analysis in the treatment with some antidepressive drugs (imipramine, amitriptyline, dibenzepine, dimethacrine).


The comparison of the effects of atropine and benactyzine on some structures of limbic system of the rats.


Automated processing of medical prescriptions.


The effect of reserpine and nortriptyline on the excretion of 17-hydroxysteroids.


An ttempt to group doctors according to their prescribing behaviour and their diagnostic practice.


The cephalic arterial system in mole-rats (Spalacidae) bamboo rats (Rhizomyidae), jumping mice and jerboas (Dipodoidea) and dormice (Gliroidea) with special reference to  the systematic classification of rodents.


Analgesics-antipyretics and etiology and pathogenesis of psychosis.


Scale for rating treatment emergent symptoms in psychiatry DVP.


Applied anatomy in toothbrushing.

Applied anatomy in toothbrushing.


On coagulation and fibrinolysis in acute renal insufficiency.


On coagulation and fibrinolysis in conservatively treated chronic uraemia.


Post mortem, coronary arteriographic, clinical and electrocardiographic findings in 80 patients investigated with coronary arteriography.


On coagulation and fibrinolysis in uremic patients on maintenance haemodialysis.


Hydroxyproline excretion in the urine and calcium metabolism during long-term treatment of thyrotoxicosis with propylthiouracil.


The lipid pattern in normals and atherosclerotics.


Blood glucose and plasma glycerol response to epinephrine infusion in normal and prediabetic subjects.


Blood lipids in patients with coronary heart disease.


Blood lipids in normals.

Blood lipids in normals.


Blood lipids in patients with atherosclerosis obliterans of the lower limbs.


The diagnosis of Ebstein's disease of the heart.


The diagnosis of hepatobiliary diseases by serum enzyme analyses.


Iron storage in alcoholic fatty liver.

Iron storage in alcoholic fatty liver.


Hemolysis in mitral valvular disease and mitral ball valve prostheses.


The rapid lowering of haematocrit by exchange transfusion of Rheomacrodex dextran 40. Its use in polycythaemia, cor pulmonale and ischaemic disease.


Platelet adhesiveness in patients with ischaemic heart disease. An assessment by three whole-blood methods.


The operative hip.

The operative hip.


Treatment of the Nabothian cyst.

Treatment of the Nabothian cyst.


Penicillin for 'penicillin-allergic' children.


Renal cell carcinoma.

Renal cell carcinoma.


Transient ischemic attacks.

Transient ischemic attacks.


Vaginal repair of ureteral injuries.

Vaginal repair of ureteral injuries.


The use of a digital computer in monitoring the condition of the fetus during labor.


High-risk obstetrics. VI. An evaluation of the effects of intensified care on pregnancy outcome.


Risk factors associated with complications of pregnancy, labor, and delivery.


Neutrophil alkaline phosphatase levels in normal and abnormal pregnancy.


Abortions by resident physicians in a municipal hospital center.


Bilirubin transfer across the human placenta.


A new scalpel guide for biopsy of the cervix.


Hysteroscopy as an adjunct in determining the extent of carcinoma of the endometrium.


A contemporary approach to recruitment in obstetrics and gynecology.


Vaginal hysterectomy as a sterilization procedure. To evaluate vaginal hysterectomy as a method of surgical sterilization, the experiences of 100 20-39 year old patients, with an average parity of 5.5, undergoing this procedure at the University of Kentucky Medical Center were compared with  an equal number of patients matched for age and gravidity undergoing puerperal tubal ligation.  Vaginal hysterectomy was performed by the Heaney technique with an average blood loss of 303 ml.  The most frequent complication was fever, occurring in 22% of the patients, caused most commonly by vaginal cuff cellulitis and urinary tract infection.  The average hospital stay for this procedure was 6 days.  In the 100 cases of tubal ligation, the total morbidity rate was 9.0%, caused most often by pelvic infection and pneumonia, and the average hospital stay lasted 4.5 days.  The mean estimated blood loss ranged from 44.1 to 53.0 ml.  Despite the greater number of operative complications associated with the vaginal hysterectomy, the procedure has 2 distinct advantages over tubal ligation: 1) absolute sterilization effectiveness, and 2) prevention of future uterine disease.  It is concluded that vaginal hysterectomy is an acceptably safe and highly effective sterilization procedure, and is particularly suited to the indigent multiparous patient who is most susceptible to future uterine disease and who will  probably not return for adequate follow-up.


The role of luteinizing hormone in human follicular maturation and function.


I. Urban interrelationships in medical education.


IV. A presumptuous experiment in rural maternal and child health care.


3. The impact of a liberalized abortion law on the medical schools. The "New York City abortion experience" for the first 8 months is reviewed.  To avoid excess charges one hospital established a flat rate for its abortion unit.  This included anesthesia.  Full time hospital staff physicians were limited to one operating day per week.  Pregnancy termination became a part of the obstetrics-gynecology residency program.  Brief discussions of abortion in Maryland and District of Columbia, the effect of abortion on the United States population growth rate, and the effect of abortion on the availability of babies for adoption follow.


[Organization of a driver's cab of a 250-ton crane].


Localization of fatty acid reesterification in the brush border region of intestinal absorptive cells.


Effect of luminal pH on the absorption of water, Na +  and Cl-by rat intestine in vivo.


A model system for the study of heteroexchange diffusion: methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells.


The role of unstirred layers in control of sugar movements across red cell membranes.


Active transport of glutamate in Streptomyces hydrogenans. I. Studies on uptake and pool size, and their interrelationship.


A radioactive label for the erythrocyte membrane.


The agglutination of erythrocytes by calcium phosphate sols.


Transport of  -aminoisobutyric acid in rabbit detrusor muscle. I. General characteristics of the uptake in vitro.


The separation of membrane proteins by polyacrylamide gel electrophoresis.


Membrane transitions in Gram-positive bacteria.


On the ATP dependence of the Ca 2+ -induced increase in K +  permeability observed in human red cells.


The corneomandibular reflex.

The corneomandibular reflex.


Electroencephalogram in juvenile endemic goiter and in acute goiter.


Discussion of adverse effects of inorganic lead salts as related to various levels of absorption of lead.


Angiopathy and cardiopathy in wild waterfowl from ingestion of lead shot.


Lead in the Connecticut environment.

Lead in the Connecticut environment.


Epidemiology of lead poisoning in New Haven children--operational factors.


Induction of cytoplasmic maturation by 1-methyladenine in starfish oocytes after removal of the germinal vesicle.


Electron microscopic demonstration of calcium in heart mitochondria in situ.


Evaluation of a new glutathione-oxidizing reagent for studies of nucleated mammalian cells.


Density gradient segregation of bone marrow cells with the capacity to form granulocytic and macrophage colonies in vitro.


Advancing the onset of mitosis by cell free preparations of Physarum polycephalum.


Heterochromatic nature of W chromosome in birds.


Maintenance of viable cells in an organ culture of mature rat liver.


Analysis of an isolated metaphase plate by quantitative electron microscopy.


Progesterone-induced maturational events in oocytes of Xenopus laevis. I. Continuous necessity for diffusible calcium and magnesium.


Progesterone-induced maturational events in oocytes of Xenopus laevis. II. Change in intracellular calcium and magnesium distribution at germinal vesicle breakdown.


Sialic acid and membrane contact relationships in peripheral nerve.


The urinary excretion of 4-hydroxy-3-methoxy mandelic acid in the elderly.


The use of the hydroxyproline--creatinine ratio in elderly patients.


The use, action and side effects of diuretics.


The use and abuse of digitalis in the elderly.


The word. A neurologist's view on aphasia.


Optimal flash rate and duty cycle for flashing visual indicators.


Foot forces exerted at various aircraft brake-pedal angles.


Auxiliary heating of the hands during cold exposure and manual performance.


The effects of age and physique on continuous-work capacity.


Effects of stimulation of brainstem reticular formation on food intake.


Single-step ligation of anterior descending branch of left coronary artery for the production of delayed ventricular arrhythmias--a modified technique.


Study of antifertility activity of the leaves of Momordica linn (Karela).


The advance of medical physiology and the role of universities and the National Science Academy.


The chemotactic activity of native and denatured serum albumin.


Human monocyte receptor sites. Failure of IgA to demonstrate cytophilia.


Effects of anti-lymphocyte, anti-macrophage and anti-thymocyte serum IgG on the immune response. II. Immediate-type and delayed-type cutaneous hypersensitivity reactions in outbred guinea pigs.


Measurement of antibody-producing capacity in man. 3. The response to flagellin from Salmonella adelaide in chronic diseases.


Peripheral lymphocyte populations. Changes in antigen requirements for stimulation in vitro.


In vitro lymphocyte responsiveness of human subjects receiving azathioprine.


In vitro diagnosis of atopic allergy. 3. Quantitative estimation of circulating IgE antibodies by the radioallergosorbent test.


Use of 1970 census of population data for air pollution research.


The effect of water vapor on ozone synthesis in the photo-oxidation of alpha-pinene.


Evaluation of a system for blood chemical analysis.


Ultrastructural aspects of lipid absorption by bovine intestinal mucosa.


Aging phenomena in spermatozoa. VI. Thermal denaturation characteristics of deoxyribonucleic acid isolated from fresh and aged bovine spermatozoa.


Antibiotics for bovine mycoplasmas.

Antibiotics for bovine mycoplasmas.


Aggregation of hydrolytic end-products of   s1 -casein.


On the treatment of vitiligo.

On the treatment of vitiligo.


Bend propagation by a sliding filament model for flagella.


Regulation of water and some ions in Gammarids (Amphipods). I. Gammarus duebeni Lilljeborg from brackish water and fresh water.


Liquefying panniculitis associated with arthritis and localized vasculitis of the ileum. Report of a fatal case.


Multiple cultures in diagnosis of dermatophytosis.


Comparison of dermatologic lesions.

Comparison of dermatologic lesions.


Regulation of water and some ions in Gammarids (Amphipods). II. Gammarus pulex.


Regulation of water and some ions in Gammarids (Amphipods). 3. Three euryhaline species.


The electric sense of sharks and rays.

The electric sense of sharks and rays.


Desert snails: problems of heat, water and food.


Oxygen tension. Distribution in water and blood at the secondary lamella of the dogfish gill.


An electrophysiological study of parapodial innervation patterns in Aplysia fasciata.


Respiration of an air-breathing catfish Clarias batrachus (Linn.).


Water relations in an insect, Thermobia domestica. I. Water uptake from sub-saturated atmospheres as a means of volume regulation.


Neural activation of the heart of the lobster Homarus americanus.


Nervous control of the motility of the alimentary canal of the silver carp.


The swimming energetics of trout. I. Thrust and power output at cruising speeds.


The effect of hypoxia and anaemia on the swimming performaance of rainbow trout (Salmo gairdneri).


The swimming energetics of trout. II. Oxygen consumption and swimming efficiency.


In vitro studies on the environmental biology of Goniodes colchici (Denny) (Mallophaga: Isochnocera). 3. The effects of temperature and humidity on the uptake of water vapour.


The structure and function of the lateral line system in larval Xenopus laevis.


Palliative radiotherapy in carcinoma of lung. 2. Relief of superior thoracic outlet obstruction.


A study of the effects of ethidium bromide on the ultrastructure of sea urchin embryos.


Wharton duct problem.

Wharton duct problem.


The road to lung failure.

The road to lung failure.


Encapsulation of clear cell adenocarcinoma of the kidney by fibrotic tissue.


Corticosteroids and lymphoid cells in vitro. I. Hydrocortisone lysis of human, guinea pig, and mouse thymus cells.


Comparison of amino acid concentrations between plasma and erythrocytes. Studies in normal human subjects and those with metabolic disorders.


The effect of a lymphotoxic factor in the sera of patients with multiple sclerosis and acute leukemia on the metabolism of normal and leukemic lymphocytes.


Lipemia in rodent iron-deficiency anemia.


Glutathione oxidation and biophysical aspects of injury to human erythrocytes.


Transfer RNA's and human lymphocyte transformation.


The treatment of osteoporosis with disodium ethane-1, 1-diphosphonate.


The evolution of papain emphysema in the rat.


Quantitation of the pathways of fructose metabolism in normal and fructose-intolerant subjects.


Effects of hypertonic solutions infused intravenously in rabbits. I. Metabolic acidosis and lactic acidemia.


Interrelation of intestinal transport system for manganese and iron.


A new approach for determining red cell life span by incorporating C 14 -glucose into glycosphingolipids of membrane.


Pressor effects of the tail-cuff method in awake normotensive and hypertensive rats.


Structure-activity relationships in antifungal agents. A survey.


Crystal structure of dl-brompheniramine maleate (1-(p-bromophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine maleate).


Steroidal androgen biosynthesis inhibitors. 23,17beta-acylaminoandrost-4-en-3-ones and 3 previously known nonsteroids were synthesized and screened as inhibitors of 17,20-lyase, a step in androgen synthesis from progesterone or OH-progesterone.  The screening involved measuring side chain cleavage (carbon-14-acetate release) from 21-carbon-14-17alpha-OH-progesterone by rat testis microsomes.  The amide, urea, guanidino and carbamate derivatives were also tested by conversion of cholesterol to pregnenolone by a bovine corpora lutea acetone powder, by conversion of corticosterone to 18-OH-corticosterone by crude adrenal  mitochondria, and by feeding to male rats to check effect on adrenal weight and testis testosterone level.  More than 80% inhibition was achieved with androst-4-en-3-ones having the C-17beta carbamate, formamido, acetamido and ureido groups.  These compounds did not inhibit OH-corticosterone synthesis.  6-alpha methylation inhibited the lyase 50-70%.  1 compound 17-beta-ureidoandrost-1,4-dien-3-one was fed to male rats for 6 weeks at 500 mg per kg; it reduced testis testosterone but not adrenal weight.  Selective inhibition of androgen synthesis would be useful for treating benign prostate hypertrophy, hirsutism, acne and androgen dependent tumors.


Interdependence between physical parameters and selection of substituent groups for correlation studies.


Muscarinic receptors. Derivatives of 7-oxabicyclo(2.2.1)heptane.


Inhibitors and stimulators of cholesterolgenesis enzymes. A structure-activity study in vitro of amino and selected N-containing analogs of 5 -cholestane-3 ,5 ,6 -triol.


Conformational study oof catecholamine receptor sites. 7. Syntheses of erythro- and threo-3-amino-2-(3,4-dihydroxyphenyl)-2-butanol hydrochlorides and erythro- and threo-2-amino-3-(3,4-dihydroxyphenyl)butane hydrochlorides.


Acenaphthene chemistry. 2. Synthesis and antiinflammatory activity of 1-(2-(dimethylamino)ethyl)2,2-dimethyl-1-acenaphthenecarboxamide.


Synthesis and antihypertensive properties of some N-(guanidinoalkyl)pyrrolidines.


Studies on carbanilic acid esters of cyclic amino alcohols. 4. Esters of pyrrolidinols and piperidinols as local anesthetics.


Thiazolothiazoles. 3. Synthesis and biological evaluation of functionalized dialkyl derivatives from  , , , -tetramethylthiazolo(5,4-d)thiazole-2,5-dibutyronitrile.


Inhibitory action of  -(4-chlorophenoxy)- -methylpropionic acid analogs on cholesterol biosynthesis and lipolysis in vitro.


Griseofulvin analogs derived from transformations of 5'-formylgriseofulvin.


6-Chlorochroman-2-carboxylic acids. Synthesis and biological evaluation as antagonists for cholesterol biosynthesis and lipolysis in vitro.


Synthesis and biological response of some 3-iminoprogestins.


-lactam antimicrobial agents which possess antifungal activity.


Vitamin B 6  analogs. An improved synthesis of 3-hydroxypyridine-4-carboxaldehyde.


Insect chemosterilants. 10. Substituted dithiobiurets.


Peptides with terminal tyrosyl and phenylalanyl groups.


Absence of the relationship between ultrastructure and metabolic state of heart mitochondria in situ.


Metabolic studies on heart preservation. The influence of some exogenous substrates under hypothermic and hyperbaric conditions.


Effect of propranolol on catecholamine content of injured cardiac tissue.


Effect of propranolol on the metabolism and function of the rat heart.


Social stress and psychiatric disorder.

Social stress and psychiatric disorder.


Sucide attempts following acute depression.


The personal future and suicidal ideation.


Hyperactive children as teenagers: a follow-up study.


A method of assessing short term creatinine excretion in acute schizophrenics.


Peripheral versus central adaptation in the crustacean visual system.


Pupillary reactions to single light pulses in psychiatric patients and normals.


Effect of chronic disuse of rat soleus neuromuscular junctions on postsynaptic membrane.


Cerebellar and labyrinthine influences on single vestibular neurons identified by natural stimuli.


Processing of visual inputs by brain of Limulus.


Dynamic characteristics of stretch reflex using force inputs.


A control model of stretch reflex.

A control model of stretch reflex.


Intersegmental and intrasegmental distribution of mutual inhibition of Renshaw cells.


Methoxyflurane anesthesia for cesarian section.


The effect of progesterone on hepatic metabolism in animals and humans.


Progestational agents and blood coagulation. 3. Menstrual cycle effects.


Electrocautery for early cervical neoplasia.


Anemia in pregnancy.

Anemia in pregnancy.


Cancer and lipid depletion.

Cancer and lipid depletion.


The effect of 5-fluorouracil on small bowel mucosa.


Growth characteristics of the stilbestrol-induced hamster kidney tumor.


Morphology of thymic grafts exposed to lymphomagenic virus.


The importance of tumor size in prognosis for resected bronchogenic carcinoma.


Inhibition of lymphocyte blastogenesis by platinum compounds.


Anatomical demonstration of the vestibulo-ocular projections in the cat.


Congenital atresia of the larynx with endolaryngeal surgical correction: a case report.


Vocal cord remobilization in the canine larynx: an histologic evaluation.


Transoral transpalatal approach for resection of clival chordoma.


Delayed healing: the rationale for zinc therapy.


Surgical anatomy of maxillary and ethmoidal sinuses--a reappraisal.


Mesenchyme in the middle ear.

Mesenchyme in the middle ear.


Cell kinetics of the 11 and 12-day mouse otocysts.


The mechanism of excitation of the hair cells in the cochlea.


The privileged adolescent.

The privileged adolescent.


Ultrasound in medicine and biology.

Ultrasound in medicine and biology.


Truncal, selective or highly selective vagotomy.


Medical abortion in South Australia. The first 12 months under new legislation.


Electrocardiographic changes in hyperthyroidism.


Chronic or latent melioidosis.

Chronic or latent melioidosis.


Rapid atrial fibrillation simulating ventricular tachycardia in the Wolff-Parkinson-White syndrome.


The differential diagnosis of dementia.

The differential diagnosis of dementia.


A computer matching service for the appointment of new medical graduates to their first hospital posts in Victoria and Tasmania.


A darker side of life.

A darker side of life.


National Health Service.

National Health Service.


National Health Service: referral of patients.


Prescribing of oral contraceptives to minors.


Concurrent session: modern trends in the problem of cancer.


Concurrent session: postgraduate education and accreditation.


The analgesic powder.

The analgesic powder.


Concurrent session: drug metabolism and the liver.


Therapeutic guidelines and side effects encountered during L-dopa therapy in 100 cases of parkinsonism.


Medicine and the law.

Medicine and the law.


An out-patient programme for L-Dopa therapy in Parkinson's disease.


Bacterial spread in polyethylene tubing. A possible source of surgical wound contamination.


Ochronotic arthropathy. Description of a case with observations on the mode of formation of an osteophyte.


The general practitioner and the region.


Plenany session: genetics.

Plenany session: genetics.


Concurrent session: advances in management of joint diseases.


Concurrent session: airways obstruction.


The Stoneleigh Abbey poisoning case.

The Stoneleigh Abbey poisoning case.


Symposium on organ transplantation.

Symposium on organ transplantation.


Electrolyte dynamics in hypertonic saline-induced abortions.


Difficult Majzlin spring removals.

Difficult Majzlin spring removals.


Placental aspects of fetalheart rate patterns.


Hemangioma of the ovary. A case report.

Hemangioma of the ovary. A case report.


Primary Hodgkin's disease of the ovary. A case report.


Cystic granulosa cell tumor with massive hemoperitoneum: light and electron microscopic study.


Pure gonadal dysgenesis associated with a single umbilical artery. A case report.


Glucose tolerance testing during pregnancy. Comparison of standard 3-hour glucose tolerance test with a single 2-hour glucose-load test.


Testicular feminization syndrome without and with sexual hair.


Postmenopausal bleeding from atrophic endometrium.


Venous changes in the endometrium of myomatous uteri.


Endometrial hyperplasia treated by progestins. This study of 16 patients compares treatment for adenomatous or atypical hyperplasia with one of three schedules of oral progestational drugs.  Treatment of endometrial hyperplasia with megestrol, 80 mg daily for 6 weeks, was not satisfactory with the first 5 patients.  Treatment was then prolonged to 9 weeks and 4 additional patients so treated.  Another 7 patients were treated with medroxyprogesterone acetate (Provera), 80 mg daily for 6 weeks.  All medication was given orally.  Patients ranged from 36 to 60 years of age with parity from 0 to 10.  Endometrial biopsies were done at intervals.  All but 1 had a complete remission under therapy.  This patient's endometrium progressed from atypica to carcinoma in situ.  At hysterectomy glandular hyperplasia with focal carcinoma in situ in the endometrium, adenomyosis, and cellular leiomyomas were found.  Remissions persisted only in 5, the longest period being 4 years.  Hysterectomy was required in 6.  None developed invasive carcinoma.  Patients are mildly symptomatic.  It is thought that continuous progestational treatment for indefinite periods may be necessary if hysterectomy is to be avoided.


Porphyria cutanea tarda induced by natural estrogens. A case report.


Postmenopausal endometrial tuberculosis.


The legal aspects of the controversy over sex education in the public schools.


Cannula curettes for office diagnostic D & C.


Lateral ovarian transposition. Ovarian relocation in patients with Hodgkin's disease.


Present status of amniocentesis in intrauterine diagnosis of genetic defects. Practical and scientific aspects of prenatal detection of genetic disorders is discussed.  The indications for intrauterine detection of familial biochemical and particular chromosomal disorders require assessment of the risks of transabdominal amniocentesis and of the reliability of diagnosis.  A high degree of experience in cultivating amniotic fluid cells and in performing diagnostic tests is required.  The obstetrician performing the amniocentesis should be responsible for referring the family to a physician who will perform the abortion.  A high-risk group for which amniocentesis may be especially important includes families in which 1 parent is a carrier of a chromosomal rearrangement and in which the woman is a known carrier of an X-linked recessive disorder so that sex  determination is important.  A moderate-risk group includes women who become pregnant after age 40 in which the risk of having a child with a chromosomal aberration is greater than 1%.  A low-risk group includes women over 35 and women who have previously borne a child with trisomic Down's syndrome.  The experience gained in over 300 patients suggests that transabdominal aminocentesis carries minimal risks to mother and fetus.  Analyses of amniotic fluid obtained by amniocentesis have resulted in antenatal diagnoses of Pompe's disease (deficient alpha-1, 4-glucosidase), Tay-Sachs disease (deficient hexosaminidase A), mucopolysaccharidosis (quantitative and  qualitative changes in mucopolysaccharides), methylmalonic aciduria (increased methylamlonate), and adrenogenital syndrome (increase 17-ketosteroids and pregnanetriol).  There is a lack of consensus on the reliability of several of these diagnoses resulting from the direct analysis of amniotic fluid.  Analyses of uncultured amniotic fluid cells have resulted in diagnoses of Pompe's disease (ultrastructural changes) and Tay-Sachs disease.  Analyses of cultivated amniotic fluid cells have enabled diagnoses of galactosemia (deficient galactose-1-phosphate uridyl transferase), X-linked uric aciduria (by autoradiography), lysosomal acid phosphatase deficiency, metachromatic  leukodystrophy (deficientaryl sulfatase A), mucopolysaccharidosis, cystic fibrosis (metachromatic granules), and Marfan's syndrome (metachromatic granules).  Methylmalonic aciduria has been detected in utero by marternal methymalonate excretion.  Adrenogenital syndrome has been detected by urinary estriol.


Practice of obstetrics and gynecology in the United States.


Some observations on so-called fibrinoid necrosis of placental villi. An electron-microscopic study.


Organotrophy of N-2-fluorenylacetamid (2-acetylaminofluorene) concerning auditory meatus tumors in two different strains of rats.


The influence of aminoacetonitrile on the skeleton and the tensile strength of tendinous attachments in the rat (morphological and functional investigations).


Tumour cell volume changes in vivo induced by heparin.


Parathyroid cell growth and proliferation in nephrectomised rats.


Disseminated tuberculosis complicated by pancytopenia.


Protein malnutrition after partial gastrectomy with duodenocolic fistula.


Recurrent meningioma presenting as a parotid swelling.


Sarcoidosis and amyloidosis.

Sarcoidosis and amyloidosis.


Hyperbaric oxygen therapy: physiological considerations.


Hyperbaric oxygen: patient safety.

Hyperbaric oxygen: patient safety.


Oxygen toxicity.

Oxygen toxicity.


Hyperbaric oxygen treatment in the Royal Air Force.


"Patientese": some thoughts on pre-operative and post-operative patient psychology.


Etiology of tracheal stenosis following cuffed intubation.


The normal physiology of lipid transport.


Electrophoresis of plasma lipoproteins.

Electrophoresis of plasma lipoproteins.


Inherited disorders of serum lipoproteins.


Lipids, lipoproteins and atherosclerotic lesions.


Classification of hyperlipidaemias.

Classification of hyperlipidaemias.


Laryngology today.

Laryngology today.


An automated technique for the study of the development of cerebral mechanisms subserving linguistic skill.


Cerebral dysfunction and physical growth: the overgrown child.


The fibrinolytic system.

The fibrinolytic system.


Fibrinolysis in pregnancy.

Fibrinolysis in pregnancy.


Fibrinolysis in cutaneous vasculitis.

Fibrinolysis in cutaneous vasculitis.


Ocular complications of transantral decompression for thyrotrophic exophthalmos.


Management and prognosis of secondary hyphaema.


Open-angle glaucoma presenting as conjunctivitis.


Trial of surgical versus medical therapy in glaucoma simplex.


Shadows on the disc.

Shadows on the disc.


The cellular dynamics of granulomas.

The cellular dynamics of granulomas.


Granuloma formation in lymph nodes.

Granuloma formation in lymph nodes.


Control of fertility. The general practitioner's role.


Control of fertility.

Control of fertility.


Sarcoidosis and Crohn's disease.

Sarcoidosis and Crohn's disease.


Place and timing of contraception and sterilization.


Precancerous conditions of the large bowel.


The georgraphical pathology of bowel cancer and some related diseases.


Possible relationships between bowel cancer and dietary habits.


Ileorectal anastomosis: review 1952-1968.


Medical management of ulcerative colitis.


Surgical treatment of ulcerative colitis.


Pathology of ulcerative colitis.

Pathology of ulcerative colitis.


Sonar--further scope and prospects.

Sonar--further scope and prospects.


The safety of ultrasound.

The safety of ultrasound.


Leiomyosarcoma of the epididymis.

Leiomyosarcoma of the epididymis.


Normal angiographic patterns of the inferior mesenteric artery.


Chondrodystrophia calcificans congenita.


Radiographic changes of the small intestine in lymphoid hyperplasia associated with dysgammaglobulinemia. A case report.


Urographie par perfusion.

Urographie par perfusion.


Some remarks on vertebral arteriography.


Queckenstedt's test and the investigation of the cervical vertebrae with contrast medium.


Vascular impressions on the renal pelvis.


Evaluation of television contribution to the annual genetically significant radiation dose of the population.


Radiological health data and reports. Section II. Water.


Interstate carrier drinking water analysis program, 1970.


Tritium surveillance system, January-March 1971.


Radiological health data and reports. Section 3. Air and deposition. Radioactivity in airborne particulates and precipitation.


Reported nuclear detonations, June 1971.


Report of the venting of the December 18, 1970, underground nuclear detonation.


Ultrasonic imaging of in vivo bubbles in decompression sickness.


Measurement of ultrasound velocity in human tissue.


Bordetella bronchiseptica pneumonia in guinea-pigs. Description of the disease and elimination by vaccination.


Dry and wet hysterectomy.

Dry and wet hysterectomy.


Specificity of sensory messages mediated through chorda tympani fibres with multiple sensitivity to gustatory and thermal stimuli.


The effect of glucagon on intestinal motility and blood flow.


Salivary secretion in the rat in a hot environment.


Effect of reduced perfusion pressure on intrarenal distribution of blood flow in dogs.


Efferent impulses in the chorda tympani nerve of the rat.


The intracellular pH' in the brain in acute and sustained hypercapnia.


Characterization of simple and composite uptake systems in cells and tissues by competition experiments.


Studies of monosaccharide permeability of arterial tissue and intestinal smooth muscle; effects of insulin.


Uptake of serotonin in blood platelets in vitro. II. Further studies on the effects of small anions.


Effects of pilocarpine on L-dopa turnover in the exocrine rat pancreas.


The effect of intense treatment with hypotensive drugs on structural design of the resistance vessels in spontaneously hypertensive rats.


The distribution of Na in intestinal villi during absorption of sodium chloride.


The ethics of addiction.

The ethics of addiction.


A commentary on "The Ethics of Addiction".


Psychiatric screening through multiphasic health testing.


The social structure of a heroin copping community.


Idiosyncratic patterns of learning and word association during mania.


Professional and community: pathways toward trust.


Langner's Psychiatric Impairment Scale: a short screening device.


Behavior therapy of hysterical fits.

Behavior therapy of hysterical fits.


Toward a continuum of formal and continuing education.


The teaching of psychiatry to the nonpsychiatrist physician.


Is soviet psychiatric training relevant in America?


Psychiatric track program: design and experience.


Psychiatric education: new challenges.

Psychiatric education: new challenges.


The place of humor in psychotherapy.

The place of humor in psychotherapy.


The prevalence of alcoholism in a community general hospital.


Rapid tranquilization.

Rapid tranquilization.


A study of conversion symptoms in psychiatric outpatients.


The staccato syndrome: a new clinical entity in search of recognition.


Drugs and the youthful police informer.

Drugs and the youthful police informer.


Meprobamate: efficacious or not?

Meprobamate: efficacious or not?


Why patients do not take their medication.


Schizophrenics: the efficacy of phenothiazines.


Security clearances and confidentiality: another view.


Draft resisters: are many of them really ill?


Pathological intoxication.

Pathological intoxication.


Competency hearings: a matter of legal tactics.


Metapsychiatry and the ultraconscious.

Metapsychiatry and the ultraconscious.


Anesthesia and the microcirculation.

Anesthesia and the microcirculation.


Anesthetic-induced abortion?

Anesthetic-induced abortion?


Quantitative analysis of microvascular diameters during pentobarbital and thiopental anesthesia in the bat.


The minimum alveolar concentration of enflurane in man.


Anesthesia, pregnancy, and miscarriage: a study of operating room nurses and anesthetists.


Effects of halothane, anoxia, and hemorrhage upon canine whole-body, skeletal muscle, and splanchnic excess lactate production.


The effect of age on the rate of increase of alveolar anesthetic concentration.


Forane uptake, excretion, and blood solubility in man.


A respiratory nomogram.

A respiratory nomogram.


Hypoxia, hyperdynamic circulation, and the hazards of general anesthesia in patients with hepatic cirrhosis.


Automatic ultrasound monitoring of blood pressure during induced hypotension.


Anesthesia for right hepatic lobectomy in a child: an exercise in blood volume management.


More on minipigs and metabolism.

More on minipigs and metabolism.


"Gassing" a water bath.

"Gassing" a water bath.


Hyperthermia during a second anesthesia.


Peer review.

Peer review.


Instructional objectives in dermatology.


Porokeratosis plantaris, palmaris, et disseminata. A third type of porokeratosis.


Inflammatory linear verrucose epidermal nevus.


Persistent toxic erythema and chronic urticaria. Possible association with the use of measles virus vaccine.


Primary cutaneous blastomycosis.

Primary cutaneous blastomycosis.


Zosteriform porokeratosis of Mibelli.

Zosteriform porokeratosis of Mibelli.


Thrombosed varix of oral cavity.

Thrombosed varix of oral cavity.


Perifollicular xanthomatosis.

Perifollicular xanthomatosis.


In defense of lymphomatoid papulosis.

In defense of lymphomatoid papulosis.


Lymphomatoid papulosis.

Lymphomatoid papulosis.


Tinea pedis in Greece.

Tinea pedis in Greece.


Allergic contact dermatitis from nystatin.


Contact dermatitis due to nystatin.

Contact dermatitis due to nystatin.


25 percent glutaraldehyde solution for warts.


Photo-urticaria.

Photo-urticaria.


Kaposis sarcoma and diabetes mellitus.

Kaposis sarcoma and diabetes mellitus.


Psychogenic purpura: platelet factor 3 deficiency.


Basal cell nevus syndrome.

Basal cell nevus syndrome.


Pemphigus erythematosus.

Pemphigus erythematosus.


Polyvalent light sensitivity (persistent light reactivity?); allergic contact sensitivity to sulisobenzone.


Poikiloderma?

Poikiloderma?


Folliculitis decalvans.

Folliculitis decalvans.


Talon noir.

Talon noir.


Primary acquired hypogammaglobulinemia, diabetes mellitus, recurrent pyoderma, and obesity.


Bullous disease of childhood.

Bullous disease of childhood.


Cicatricial pemphigoid.

Cicatricial pemphigoid.


Pustular psoriasis.

Pustular psoriasis.


On the relation between the orientation of the semicircular canals and the cranial index in man.


Intralenticular foreign bodies.

Intralenticular foreign bodies.


Senile disciform degeneration of the macula. Retinal arterialization of the fibrous plaque demonstrated clinically and histopathologically.


Dose-response analysis of echothiophate iodide.


Aphakic flat anterior chamber. Treatment by anterior vitriotomy.


Granulomatous sclerouveitis. Regression of ocular lesions with cyclophosphamide and prednisone.


Lateral lip sclerectomy.

Lateral lip sclerectomy.


Tenonectomy. Treatment of epibulbar extension of choroidal melanomas.


Lateral and longitudinal magnification in direct and indirect ophthalmoscopy.


Experimental vitrectomy. Instrumentation and surgical technique.


Instant color prints using the Zeiss fundus camera; a simple, inexpensive method.


Passive transfer of experimental allergic uveitis.


Angiography of the retina with indocyanine green.


The ocular hypotensive effect of sodium lactate in rabbits.


Transient internal ophthalmoplegia. Areflexia and methacholine hypersensitivity with unidentified systemic disease.


Steroid inhibition of leukocyte defense system in mycoplasmal uveitis.


Residence time of particles in urban air.


Determination of trace concentration of ammonia in the atmosphere using pyridine-pyrazolone reagent.


Determination of particulate composition, concentration and size distribution changes with time.


Direct current discharge emission spectra for detection and identification of some air pollutant compounds.


The applications of optical correlation techniques to the remote sensing of SO 2  plumes using sky light.


Lidar study of the Keystone stack plume.


More about education in radiology.

More about education in radiology.


Sampling and analysis considerations in evaluating levels of atmospheric lead.


Complications of cerebral angiography--catheter technique.


Supernumerary intrathoracic rib--an easily recognized rare anomaly.


Transfemoral catheter aortography in dissecting aneurysm.


The value of chemotherapy in ovarian cancer.


Nephrotomography. A simplified technique and results.


A survey of colon examination techniques in Australia and New Zealand, with a review of complications.


The results of treatment of carcinoma of the cervix in Western Australia.


The preauricular sulcus.

The preauricular sulcus.


The synovial changes at the elbow in rheumatoid arthritis.


The image intensifier in hip pinning. A comparison with conventional radiography.


Inhibition by adenosine of the cortisol-induced liver glycogen accumulation in adrenalectomized rats.


Biosynthesis of cholesterol and cholesterol acetate in dendrobatid arrow poison frogs.


Changes in liver blood flow during enzyme induction.


Effect of monoamine oxidase inhibitors on qualitative alterations in enzymatic properties of mitochondrial monoamine oxidases.


Influence of alkane-bis-onium compounds upon the activity of the AchE and upon its inhibition by DFP.


The fate of ( 14 C)L-3,4-dihydroxyphenylalanine in isolated perfused rat hearts.


2,3-Dihydro-1H-imidazo(1,2-b)pyrazole: a new inhibitor of deoxyribonucleic acid synthesis.


Inhibition of renal tubular transport of morphine by  -diethylaminoethyl diphenylpropylacetate in the chicken.


Effects of selected arylhydroxamic acids on lymphocyte mitogenesis.


Influence of dimethylsulfoxide on transmembrane transport.


Rat strain differences in the activity of hepatic microsomal enzymes.


Effect of reserpine on release of ( 3 H)noradrenaline, ( 3 H)dopamine and ( 3 H)metaraminol from field stimulated rat iris.


Protein-carbohydrate interaction. On the mode of bonding of aromatic moieties to concanavalin A, the phytohemagglutinin of the jack bean.


Acetylcholine as a possible sensory mediator in rabbit corneal epithelium.


Influence of a chronic treatment on the distribution of amitryptiline and metabolites in rabbit brain.


Effects of L-2-pyrrolidone-5-carboxylate on hepatic adenosine triphosphate levels in the ethionine-treated rat.


Entry and distribution of hexamethonium in the central nervous system.


Alteration of proline hydroxylase activity by glucocorticoids.


Effect of ethanol on glucose and amino acid metabolism in brain.


Slowed lysosomal enzyme release and its normalization by drugs in adjuvant-induced polyarthritis.


Metabolism and biliary excretion of phenanthridinium salts. I. Nature of the biliary metabolites.


Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitro.


Effect of pretreatment with methotrexate on the reduction of dihydrohomofolic acid in mice.


Dissimilar effects of anti-inflammatory drugs on stability of lysosomes from peritoneal and circulating leukocytes and liver.


Action of tannic acid on frog muscle.

Action of tannic acid on frog muscle.


Uptake and phosphorylation of D-glucosamine-1- 14 C in the human platelet.


Regional distribution of persistently bound reserpine in rat brain.


Monosodium L-glutamate--inhibition of glucose uptake in brain as a basis for toxicity.


De novo synthesis of acetylcholinesterase in guinea pig retina after inhibition by pinacolyl methylphosphonofluoridate.


Thermodynamics of the binding of haptens to rabbit anit-2,4-dinitrophenyl antibodies.


Species and strain differences in the epimerization of 3-beta, 17-beta-dihydroxy-17-alpha-ethynyl-delta-5 (10)-estrene to the 3 alpha-hydroxy epimer.


Study of the nature of the metal-binding sites and estimate of the distance between the metal-binding sites in transferrin using trivalent lanthanide ions as fluorescent probes.


Interactions of Fructose 1,6-diphosphate, substrates, and monovalent cations with yeast pyruvate kinase monitored by changes in enzyme fluorescence.


Fructose 1,6-diphosphate enhances inactivation of yeast pyruvate kinase at 23. Evidence for a stabilized dimer intermediate.


Rat liver omega-amidase. Purification and properties.


Mitochondrial glutamate aspartate transaminase. Differential action of thiol reagents with the supernatant enzyme.


Kinetics of carboxypeptidase A, pH and Temperature dependence of tripeptide hydrolysis.


Mechanism of action of uncouplers of oxidative phosphorylation.


Structural studies on Dendrostomum pyroides hemerythrin.


Steroid conjugates. VII. Preparation of N-acetylglucosaminides of 17-alpha-and 17-beta-estradiol.


Hydroxylated derivatives of 5-methyl-5,6,7,8-tetrahydrofolate.


Disruption of low- and high-density human plasma lipoproteins and phospholipid dispersions by 1-anilinonaphthalene-8-sulfonate.


Chromatography of synthetic polyribonucleotides on columns of benzoylated diethylaminoethylcellulose.


Flocculation in a fission yeast: an initial step in the conjugation process.


The effect of temperature on lysis of cells and cell walls of Bacillus psychrophilus.


Phylogenetic significances of the photoreactivable sectors of species of Hansenula.


Purification of epidermidins, new antibiotics from staphylococci.


An expanded genomic map of Staphylococcus aureus.


The physiology of production of the antibiotic cyathin by Cyathus helenae.


Induction of malignant lymphomas by N,N'-dimethylnitrosourea in adult mice.


Growth of mouse mammary tumor related to host resistance.


RNA metabolism in mouse myeloma cells.

RNA metabolism in mouse myeloma cells.


Evaluation of cell damage in immune reactions by release of radioactivity from  3 H-uridine labeled cells.


2,2'-O-cyclocytidine, an antitumor cytidine analog resistant to cytidine deaminase.


Comparative studies on biological characteristics of transplantable rat leukemia, DBLA lines.


Familial aspects of inflammatory bowel disease.


Kinetics of inhibition of canine gastric secretion by vasopressin.


A comparison of the site of action of gastrin I on lower esophageal sphincter and antral circular smooth muscle.


Effects of some drugs on electrical activity of the isolated colon of the cat.


Studies on the mechanism of fasting hyperbilirubinemia.


Digestive diseases in the new health care system. A statement by the Steering Committee of the American Association for the Study of Liver Diseases.


9- -fluorohydrocortisone induced ascites in alcoholic liver disease.


Ulcerative colitis in female monozygotic twins and a female sibling.


Induced alterations in composition of bile of persons having cholelithiasis.


Cholinergic drugs and the beagle colon.

Cholinergic drugs and the beagle colon.


Crohn's disease and periosteal new bone formation.


Pyloric sphincter incompetence in man--a nonphysiological variant.


Polypoid reparative mucosal proliferation at the site of a healed gastric ulcer: sequential gastroscopic, radiological, and histological observations.


Pancreatic exocrine function in chronic alcoholics.


Production of low x-ray exposure rates.

Production of low x-ray exposure rates.


Comment on "a new technique for reactor siting dose calculations".


Improvements on both energy and direction dependence of the Mg 2 SiO 4  thermoluminescence dosimeter.


The neutron spectra and the resulting fluence-kerma conversions for  241 Am-Li( , n) and  210 Po-Li( , n) sources.


The President's message.

The President's message.


Misguided editorial.

Misguided editorial.


A new radon progeny personnel dosimeter.


Techniques for separating americium from urine after DTPA therapy.


Dietary intake of  210 Pb.

Dietary intake of  210 Pb.


DTPA therapy for chelation of  239 Pu in bone: the influence of bone remodelling.


Gamma-continuum at the air-land interface.


Dosimetric field quantities in health physics.


Accumulation of  137 Cs and  85 Sr by Florida forages in a uniform environment.


The latitudinal variations of  55 Fe in man and cattle.


A recording exposure control for x-ray machines.


The application of appraisal techniques to radiation protection activities.


Long-term evaluation of the biological half-life of tritium.


Evidence against nutritional adaption of tolerance to lactose.


Concordant metaphyseal dysostosis type Schmid in twins.


Structural variability of the normal human karyotype.


Non-random association of human acrocentric chromosomes.


On the position of chromosomes in prepared mitosis figures of human fibroblasts.


Familial translocation involving chromosomes 6, 14 and 20, identified by quinacrine fluorescence.


A family showing strongly reduced ability to open the mouth and limitation of some movements of the extremities.


Fibroblast culture in Werner's syndrome.


Cytogenetical and clinical investigations in aplastic anaemia (Fancomi's type).


On the phenotype distribution of red cell acid phosphatase in Czechoslovakia. The district of Ceské Budĕjovice.


Determination of three enzyme polymorphisms in one electrophoretic step on horizontal polyacrylamide gels.


Glibenclamide (HB 419) in the management of diabetes mellitus.


Effect of butter fat and onion on coagulability of blood.


Effect of onion on electrophoretic pattern of serum proteins in alimentary lipemia.


A correlation study of birth weight and some maternal factors.


The immunological test for pregnancy: an evaluation.


Continuing education in pharmacotherapeutics.


Congenital absence of the vas deferens.

Congenital absence of the vas deferens.


Conquest of deficiency diseases. 9. Nutritional anemias.


Report on cyclamates by the committee set up by the Israel ministry of health.


Air pollution control training in colleges and universities in the United States.


Prevention of thromboembolic disease after elective surgery of the hip.


Open reduction of congenital dislocation of the hip by Ludloff's method.


The modified Blair fusion for fractures of the talus.


Surgical treatment of the painful shoulder contracture in the stroke patient.


Non-ischemic contractures of the intrinsic muscles of the hand.


Flexor-tendon grafts in the fingers and thumb. A study of factors influencing results in 1000 cases.


Observations on the effects of tourniquet ischemia.


Rupture of the ulnar collateral ligament of the thumb (gamekeeper's thumb). Correction by dynamic repair.


Juxtacortical chondrosarcoma of the hand.


Naviculo-capitate fracture syndrome. Review of the literature and a case report.


Overwhelming sepsis associated with group A beta hemolytic streptococci.


The influence of triamcinolone acetonide on joint stiffness in the rat.


Stimulation of fracture healing by direct current in the rabbit fibula.


Studies of patients with osteogenesis imperfecta.


Central dislocation arthroplasty of the hip. a follow-up study.


Paget's disease of the atlas and axis.

Paget's disease of the atlas and axis.


Nerve injuries complicating Monteggia lesions.


Reduplication of bones of lower extremity.


Brief notes. Methods for locating the "missing patients" in long-term follow-up studies.


Normal and induced synthesis of  -aminolevulinic acid synthetase in developing chick liver.


Instability of the epithelial-mesenchymal interaction in the eight-day embryonic chick thyroid.


A method for the production of pigmentless eggs in Xenopus laevis.


Expression of the paternal genes for glutamate-oxaloacetate transaminase (GOT) during embryogenesis in Xenopus laevis.


Behavioral thermoregulation by the white rat at high ambient temperatures.


Development of the rat salivary glands. I. Accumulation of parotid gland DNase activity.


Drinking attitudes and drinking behavior: an exploratory study.


Effects of injury and stimulation of the hypoglossal nerve and superior cervical ganglion on the mitotic activity of the glossal epithelium.


Machiavellianism and individual differences in response to cognitive inconsistency.


Resistance to social influence among adolescents as a function of level of moral development.


Sanction assigment in a dyad as a function of aggression and outcome quality.


Role playing and repetition effects on opinion strength.


Effects of brief exposure to photographic vs. prose reporting of racial aggression or harmony upon certain racial attitudes.


Paraplegia due to radiation myelitis following the treatment of carcinoma of the bronchus by radiotherapy. Report of two cases.


Thoughts about the measurements of muscle tone.


The neurovegetative syndrome of vesical distension in paraplegics. Prevention and therapy.


Cineradiographic studies of some bladder-sphincter dysfunctions in paraplegia.


Prevention of urinary tract infection following spinal cord injury.


Diagnosis of impaired fetal growth in newborn infants.


Diazepam in the management of the neonatal narcotic withdrawal syndrome.


Human placental transfer of human growth hormone-I 125 .


Lipid concentration and composition in human fetal tissue during development.


Phenobarbitone enhancement of bromsulphalein clearance in neonatal hyperbilirubinemia.


The red cell peroxide hemolysis test in the differential diagnosis of obstructive jaundice in the newborn period.


An effective program for reducing group A streptococcal prevalence.


The growth and development of four XYY infants.


Guidelines for the selective use of throat cultures in the diagnosis of streptococcal respiratory infection.


The measurement of fluid deposition in humans following mist tent therapy.


Evaluations of safety packaging for the protection of children.


Hyperammonemia due to a mutant enzyme of ornithine transcarbamylase.


Ampicillinuria and ampicillin crystalluria.


Decline in serum bilirubin concentration coincident with clinical onset of kernicterus.


The use and abuse of vitamin A.

The use and abuse of vitamin A.


Committee on Indian health.

Committee on Indian health.


Expiration dates of pharmacological and biological preparations.


Polio vaccination in developing countries.


Symptomatic autism.

Symptomatic autism.


Tocopherol therapy in acanthocytosis.

Tocopherol therapy in acanthocytosis.


Who should certify the pediatrician?

Who should certify the pediatrician?


Safety measures and accidental poisoning.


Confirmation of Henoch's treatment of encopresis.


Penis tourniquet syndrome.

Penis tourniquet syndrome.


The azygos vein and its pleural reflections. I. Normal roentgen anatomy.


Lymphangitic spread of metastatic cancer to the lung. A radiologic-pathologic classification.


New preformed catheter shape for right adrenal venography.


Subaortic stenosis (discrete form). Classification and angiocardiographic features.


Fungus ball--An unusual manifestation of Coccidioidomycosis. A case report.


Congenital bronchopulmonary- foregut malformation.


The sign of the cane. A new raiological sign for the diagnosis of small morgagni hernias.


Localization of acute deep venous thrombosis in women taking oral contraceptives.


Diagnostic criteria of bilateral renovascular hypertension.


The reversed appearance sign. An early indication of significant contralateral renal disease following repair of main renal artery stenosis?


The unilateral hypoplastic lumbar pedicle.


Intra-abdominal chicken-bone abscess.

Intra-abdominal chicken-bone abscess.


Computerized radiological reporting with word retrieval using MT-ST.


Radionuclide studies in an unusual case of Dandy-Walker cyst.


Diagnostic evaluation of  67 Ga scanning of lung cancer and other diseases.


99m Tc-human albumin microspheres (HAM) for measuring the rate of gastric emptying.


Ultrasonic measurement of the aortic arch, right pulmonary artery, and left atrium.


Secondary radiation associated with diagnostic x-ray tube collimators.


Development of a diagnostic x-ray spectrometer with a lithium-drifted silicon detector for intercomparison and image analysis.


Linear energy transfer distributions for neutrons about a  252 Cf point source in tissue.


Capillary injury preceding radiation-induced myocardial fibrosis.


A cell population kinetic model for fractionated radiation therapy. I. Normal tissues.


Quantitation of relevant image information: automated radiographic bone trabecular characterization.


Human tolerance of iopanoic acid (Telepaque).


The use of thin lung shields to deliver limited whole-lung irradiation during mantle-field treatment of Hodgkin's disease.


Use of the pinhole collimator for imaging the posterior fossa on brain scans.


Black-and-white slides in ninety seconds.


Oncologic diagnostic radiology.

Oncologic diagnostic radiology.


Light adaptation in the rat retina: evidence for two receptor mechanisms. Light adapting the rat retina with transient white flashes too dim to bleach a substantial amount of visual pigment produces a change in electroretinogram spectral sensitivity and an increase in flicker fusion frequency. Increment threshold curves obtained with a long wavelength adapting stimulus and a short wavelength test stimulus show rod saturation.


Marihuana: standardized smoke administration and dose effect curves on heart rate in humans. A spirometer was used to deliver marihuana and placebo smoke to human subjects. This procedure produced linear dose-effect curves on heart rate and replicable dose effects in individual subjects. No differences were observed between experienced and inexperienced smokers in responsiveness to heart rate increases produced by marihuana.


Calcium carbonate concretions: cyclic occurrence in the hamster vagina. Three crystalline forms of calcium carbonate were identified in washings of the hamster vagina. Spherical concretions of vaterite and hexagonal concretions of calcite predominate on days 3 and 4 of the 4-day estrous cycle. Dumbbell-like concretions of aragonite predominate during pregnancy and pseudopregnancy. Each polymorph is associated with an acid-insoluble matrix. Concretions disappear after ovariectomy and reappear during daily injections of estrogen and progesterone.


DDT residues: distribution of concentrations in Emerita analoga (stimpson) along coastal California. The total concentrations (tDDT) of DDT [1,1,1-trichloro-2,2-bis(pchlorophenyl)ethane], DDD [1,1-dichloro-2,2-bis(p-chlorophenyl)ethanel, and DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene] in Emerita analoga from 19 California beaches reflect tDDT contamination nearby. Animals near the Los Angeles County sewer outfall contain over 45 times as much tDDT as animals near major agricultural drainage areas. Sediments near the outfall probably contain over 100 metric tons of tDDT-a reservoir for input into marine organisms. The effluent from a plant that manufactures DDT is a probable source.


Alkyl isocyanates as active site-specific inhibitors of chymotrypsin and elastase. Alkyl isocyanates react specifically with the two serine proteinases, chymotrypsin and elastase, to yield inactive enzyme derivatives containing 1 male of reagent per mole of enzyme. Octyl isocyanate inactivates chymotrypsin only, while butyl isocyanate inactivates both enzymes but shows greater efficiency toward elastase than toward chymotrypsin. These reagents may thus represent unique chemical "yardsticks" for the measurement of the relative dimensions of the active sites of the two very similar enzymes.


Signaled reinforcing brain stimulation facilitates operant behavior under schedules of intermittent reinforcement. When single, rewarding brain stimulations were mnade predictable by preceding them with a brief warning signal, operant behavior was established and maintained under fixed ratio 200, variable ratio 30, fixed interval 3-minute, variable interval 2-minute, and differential reinforcement of low rate 20-second schedules of intermittent reinforcement. When the warning signal was removed, overall response rate declined in all but the fixed ratio schedules and then returned to the previous rate when the signal was reinstated.


75 Se selenomethionine as a scanning agent for the differential diagnosis of the cold thyroid nodule.


Dose distribution measurements of the intracavitary after-loading unit "Cathetron" and their application in gynecological use.


Cytochemical approaches to the study of gamma-radiation injury to nervous system. Response of the cerebellum of mice.


The effect of radiophosphorus (P-32) on thymus in Swiss albino mice.


Effect of X-irradiation of the exteriorized jejunal loop on the morphology and 5-hydroxytryptamine content of the enterochromaffin cells in the mouse.


Humoral antibody response of irradiated mice treated with chemical radioprotectors.


Effect of cobalt-60 irradiation and ultra sound on barley seeds.


Reflexes from the lungs and the respiratory tract.


Clinical aspects of the nervous control of breathing.


Structure and function of temporomandibular joint innervation.


The early diagnosis of thromboembolism by ultrasound.


British surgical aid to Jordan.

British surgical aid to Jordan. The surgical commitment of No. 2 Field Hospital, R.A.M.C., during its stay in Jordan is presented. The majority of patients that were admitted had sustained war wounds, many of which were infected due to the delay in treatment. The difficulties encountered in their subsequent management are discussed. Special reference is made to the use of ketamine (Ketalar) and mafenide acetate (Sulphamylon) in the treatment of those burns cases under our care. It is the first time for many years that a British field hospital has been employed in an active rôle.


The history of the treatment of maxillo-facial trauma.


The reaction of clostridial ferredoxin with cyanide.


Circadian variations of human growth hormone serum levels. Longitudinal study.


Inhibition of hepatic cholesterol biosynthesis by 3,5-dihydroxy-3,4,4-trimethylvaleric acid and its site of action.


The use of trinitrobenzenesulfonic acid in studies on the binding of fatty acid anions to bovine serum albumin.


Separation of histones from normal rat liver nuclei into easily extractable and residual histone and characterization of the fractions.


Isolation, composition, and structure of cell walls of Trichophyton mentagrophytes.


Some properties of mitogenic components isolated from phytohemagglutinin by a preparative gel electrophoresis.


Cooperative feedback control of barley acetohydroxyacid synthetase by leucine, isoleucine, and valine.


Plasma hydroxycorticosteroids circadian rhythm in diabetic adult subjects under different types of treatment.


Isolation and partial characterization of a peptide derived from the luciferin binding site of firefly luciferase.


Studies on poly (adenosine diphosphate-ribose). X. Properties of a partially purified poly (adenosine diphosphate-ribose) polymerase.


Nuclear magnetic resonance study of the side-chain conformation of  -helical poly- -benzyl-L-aspartate.


Effects of barbiturate derivatives, sulfhydryl reagents, and oxidizing agents on the activity of adenylate cyclase from guinea pig heart and lung.


Wheat leaf RNA polymerases. I. Partial purification and characterization of nuclear, chloroplast and soluble DNA-dependent enzymes.


Caffeine metabolism by Penicillium roqueforti.


Malate dehydrogenases of leaf tissue from Spinacia oleracea: properties of three isoenzymes.


Wheat leaf RNA polymerases. II. Kinetic characterization and template specificities of nuclear, chloroplast, and soluble enzymes.


Macromolecule--small molecule interactions: analytical and graphical reexamination.


Cytochrome P-450 as a microsomal peroxidase utilizing a lipid peroxide substrate.


IUPAC-IUB Commission on Biochemical Nomenclature. The nomenclature of multiple forms of enzymes recommendations (1971).


The effects of sulfhydryl-blocking reagents on canine pancreatic ribosomes.


Tyrosine ligands to iron in hemerythrin. II. Specification of residues involved.


Regulation of cellular respiration by thyroid hormone. Spectroscopic evidence of mitochondrial control in intact rat liver.


Reaction of protein disulfide groups with Ellman's reagent: a case study of the number of sulfhydryl and disulfide groups in Aspergillus oryzae  -amylase, papain, and lysozyme.


Studies on rabbit ribonucleases.

Studies on rabbit ribonucleases.


Interaction of sodium dodecyl sulfate with tyrosyl chromophores in ribonuclease A and model compounds.


The peroxidase nature of cytochrome P-420 utilizing a lipid peroxide substrate.


Pulsed NMR measurements of the diffusion constant of water in muscle.


Standard free energy maps for the hydrolysis of ATP as a function of pH, pMg and pCa.


Fructose diphosphate aldolase of spinach leaf: primary structure around the substrate-binding site.


Viscometric determination of carboxymethylcellulase in standard international units.


Uncoupling of photophosphorylation inhibition of proton binding by quaternary ammonium salts and zwitterionic buffers.


A further study of P430: a possible primary electron acceptor of photosystem I.


Carcinoma in situ involving the laryngeal mucus glands.


Drug effects on the medial vestibular nucleus. Perrotatory response.


"Emergency" laryngectomy.

"Emergency" laryngectomy.


Anatomical measurement of the sinus tympani. A study of horizontal serial sections of the human temporal bone.


Reflections of difficult decannulation.

Reflections of difficult decannulation.


Cartilages and ligaments of the adult human larynx.


Another etiology of middle ear cholesteatoma.


"Pseudocarcinoma" of the larynx. Independent metastasis of carcinomatous and sarcomatous elements.


Pharyngomaxillary space abscess with carotid artery erosion.


Trigeminal sensory neuropathy and Bell's palsy. Report of two cases.


Tympanic neurectomy in chronic parotitis.


Clinical cases of otorhinolaryngologic diseases.


Adenotonsillectomy.

Adenotonsillectomy.


Oxygenation.

Oxygenation.


Left anterior descending coronary pulmonary artery fistula.


Family practice reports. Preceptor's experience. My medical student.


Family practice reports. Medical student's experience. My family doctor.


Hazards of laparoscopy.

Hazards of laparoscopy.


The search for reality.

The search for reality.


Botulinal toxins and the problem of nomenclature of simple toxins.


IUPAC-IUB Commission on Biochemical Nomenclature. Abbreviations and symbols for the description of the conformation of polypeptide chains. Tentative rules (1969).


Micro method for determination of reactive carbonyl groups in proteins and peptides, using 2,4-dinitrophenylhydrazine. A method is described for determining carbonyl groups that is especially suitable for use with proteins and peptides. It involves the determination of the extinction at 370nm of a sample solution after adding 2,4-dinitrophenylhydrazine. The reaction of 2,4-dinitrophenylhydrazine with pyruvoylglycine and with transaminated ribonuclease T(1) is presented; the isolation of protein hydrazones is discussed.


Purification of ribonuclease T 1  by diethylaminoethylcellulose chromatography. A procedure is described for isolating the enzyme ribonuclease T(1) from Takadiastase, an extract of the mould Aspergillus oryzae. It involves an initial concentration of the enzyme by adsorption on DEAE-cellulose followed by gradient elution. Later the enzyme is chromatographed on the same adsorbent with an eluent of constant composition. Yields of 350-380mg of ribonuclease T(1) from 500g of Takadiastase were obtained.


Protein-bound phosphorylserine in acid hydrolysates of brain tissue. The determination of ( 32 P)phosphorylserine by ion-exchange chromatography and electrophoresis. 1. Partial acid hydrolysates of proteins derived from cortical slices of guinea-pig brain were divided into two parts and fractionated by ion-exchange chromatography and high-voltage electrophoresis. 2. The apparent yield of protein-bound phosphorylserine by the ion-exchange method was about three times that obtained by electrophoresis. 3. The specific radioactivity of phosphorylserine isolated from (32)P-labelled slices by electrophoresis was twice that isolated by chromatography. 4. The discrepancies were found to be due to the presence of unlabelled phosphates of unknown composition in the ;phosphorylserine' fraction obtained by the ion-exchange method. 5. Electrical stimulation of slices respiring in the presence of [(32)P]phosphate increased the specific radioactivity of the total phosphate in the chromatographic ;phosphorylserine' fraction by 53+/-11%, as compared with only 19+/-5% for the phosphorylserine isolated by electrophoresis.


Viruses with segmented ribonucleic acid genomes: multiplication of influenza versus reovirus.


Isotopic studies of the conversion of oxophlorins and their ferrihaems into bile pigments in the rat. 1. Tritiated oxymesoporphyrins and their ferrihaems were tested as possible intermediates in the catabolism of haemoglobin. The tritiated compounds were injected into rats with biliary fistulae and the incorporation of the isotope into bile, bile pigment, urine, faeces, liver, kidney and spleen was measured. 2. alpha-Oxymesoferrihaem was extensively converted into bile pigment and specifically to the expected mesobilirubin. 3. beta-Oxymesoferrihaem was poorly converted into bile pigment and was not converted into mesobiliverdin IXbeta. The latter was independently shown to be excreted rapidly in bile. 4. The free oxyporphyrins were also poor precursors of bile pigment, and alpha-oxymesoporphyrin competed with bilirubin for excretion by the liver. 5. By analogy with the results obtained with alpha-oxymesoferrihaem it is concluded that alpha-oxyprotoferrihaem is an intermediate in the catabolism of haemoglobin, undergoing further oxidation to bile pigment under the catalysis of an enzyme of definite specificity.


Nucleic acid enzymology of extremely halophilic bacteria. Halobacterium cutirubrum polynucleotide phosphorylase. 1. Polynucleotide phosphorylase was purified 200-fold from Halobacterium cutirubrum. 2. It is membrane-associated and can be solubilized by sonication. 3. The purified enzyme requires a high ionic strength for both stability and activity. 4. It is Mn(2+)-dependent, has all three typical polynucleotide phosphorylase activities and is specific for nucleoside diphosphates. 5. The enzyme is of low molecular weight.


Nucleic acid enzymology of extremely halophilic bacteria. Gel-filtration and density-gradient-centrifugation studies of the molecular weights of Halobacterium cutirubrum polynucleotide phosphorylase and deoxyribonucleic acid- and ribonucleic acid-dependent ribonucleic acid polymerases. 1. Conditions have been established for the estimation of molecular weights of proteins by analytical gel filtration and sucrose-density-gradient centrifugation in 2.5m-potassium chloride-1m-sodium chloride; Halobacterium cutirubrum polynucleotide phosphorylase, DNA-dependent RNA polymerase and RNA-dependent RNA polymerase have been studied by these methods. 2. The RNA-dependent polymerase has also been studied by density-gradient centrifugation in the absence of salt. 3. All three proteins are of unusually low molecular weight compared with similar enzymes from non-halophilic bacteria.


Nucleic acid enzymology of extremely halophilic bacteria. Halobacterium cutirubrum ribonucleic acid-dependent ribonucleic acid polymerase. 1. Crude extracts of the extreme halophile Halobacterium cutirubrum contain separable DNA-dependent and RNA-dependent RNA polymerases. 2. The RNA-dependent enzyme has been purified about 2800-fold. 3. It requires RNA, preferably of high molecular weight, and all four ribonucleoside triphosphates to incorporate (14)C-labelled nucleoside triphosphate into an acid-insoluble, ribonuclease-sensitive product. 4. Both the stability and activity of the RNA polymerase are relatively insensitive to changes in potassium chloride or sodium chloride concentration, but incorporation is stimulated by both Mg(2+) and Mn(2+). 5. The molecular weight of the enzyme is about 17000-18000.


Study of soluble lipoprotein in rat liver mitochondria. 1. A water-soluble lipoprotein was isolated and purified from osmotically shocked preparations of rat liver mitochondria by using a technique of Sephadex-sandwich disc electrophoresis. 2. The purified lipoprotein migrates as a distinct sharp zone in high-resolution electrophoretic systems, indicating high degree of purity. 3. The lipoprotein resembles mitochondrial membranes with respect to lipid composition and lipid/protein ratio. 4. The lipoprotein and its apoprotein fraction obtained by delipidization at -18 degrees C to -20 degrees C have common properties with respect to their fluorescence spectra, instability to storage and electrophoretic mobility. 5. The purified lipoprotein has an excitation maximum at 325nm and a fluorescence maximum at 418nm. 6. Storage at 4 degrees C for 4 days or repeated freezing and thawing results in 15-30% decrease in electrophoretic mobility. 7. The patterns of incorporation in vitro of [1-(14)C]leucine into proteins of the soluble lipoprotein and of mitochondrial membrane of isolated rat liver mitochondria suggest a probable precursor role for the apoprotein in the formation of mitochondrial membrane protein. 8. Lipoprotein preparations isolated from mitochondrial fractions of rat kidney, brain and heart and of chicken and mouse liver resemble closely that obtained from rat liver mitochondria, suggesting that the soluble lipoprotein could be a distinct entity of mitochondrial origin.


The reaction of aralkyl sulphate esters with glutathione catalysed by rat liver preparations. 1. Rat liver supernatant preparations catalyse the reactions of some aralkyl sulphate esters with GSH to yield S-aralkylglutathione derivatives. 2. A glutathione S-transferase that catalyses these reactions has been purified 16-fold. 3. The purified enzyme preparation catalyses the release of sulphate ions from benzyl sulphate, 1-menaphthyl (naphth-1-ylmethyl) sulphate and phenanthr-9-ylmethyl sulphate only in the presence of GSH. It does not cause the release of sulphate ions from prop-1-yl sulphate, l-serine O-sulphate, phenyl sulphate or oestrone 3-sulphate even when GSH is added. 4. The stability and specificity of the enzyme and its response to inhibitors and to changes of pH were studied. 5. The activity of the preparation was compared with the activities of glutathione S-transferases described previously.


Studies on the control of hexosamine biosynthesis by glucosamine synthetase. 1. The nature of the feedback inhibition of hexosamine biosynthesis on rat liver glucosamine synthetase (l-glutamine-d-fructose 6-phosphate aminotransferase, EC 2.6.1.16) by UDP-N-acetylglucosamine was investigated in detail. 2. Further modifiers of physiological importance are described. Glucose 6-phosphate and AMP potentiated the UDP-N-acetylglucosamine inhibition, and UTP behaved as an activator. These three compounds only exerted their action when the feedback inhibitor was bound to the enzyme. 3. ATP also inhibited the enzyme. 4. The actions of these various effectors are discussed in kinetic terms. 5. An interpretation of these findings with reference to the regulation of hexosamine biosynthesis is presented.


Protein synthesis by membrane-bound and free ribosomes of secretory and non-secretory tissues. 1. Methods for the separation of membrane-bound and free ribosomes from rat brain (cortex) and skeletal muscle were described and the preparations characterized by chemical analysis and electron microscopy. The attachment of ribosomes to membranes is not an artifact of the separation procedure. 2. The rate of incorporation of l-[(14)C]leucine into protein in vitro by the membrane-bound and free ribosomes from these two predominantly non-protein-secreting tissues is compared with that by similar preparations from rat liver. With all three tissues the initial rate was higher for the membrane-bound preparations. 3. By using the technique of discharging nascent polypeptide chains by incubation with puromycin followed by treatment with sodium deoxycholate (Redman & Sabatini, 1966), a major difference was observed for the vectorial discharge of nascent protein synthesized both in vivo and in vitro on membrane-bound ribosomes from liver, on the one hand, and brain and muscle, on the other. Whereas a large part of nascent protein synthesized on membrane-bound liver ribosomes was discharged into the membranous vesicles (presumably destined for export from the cell), almost all nascent protein from membrane-bound ribosomes from brain and muscle was released directly into the supernatant. Incorporation of [(3)H]puromycin into peptidyl-[(3)H]puromycin confirmed these findings. There was thus no difference between membrane-bound and free ribosomes from brain on the one hand, and from free polyribosomes from liver on the other, as far as the vectorial release of newly synthesized protein was concerned. 4. Incubation with puromycin also showed that the nascent chains, pre-formed in vivo and in vitro, are not involved in the attachment of ribosomes to membranes of the endoplasmic reticulum. 5. The differences in vectorial discharge from membrane-bound ribosomes from liver as compared with brain and muscle are not due to the different types of messenger RNA in the different tissues. Polyphenylalanine synthesized on incubation with polyuridylic acid was handled in the same way as polypeptides synthesized with endogenous messenger. 6. It is concluded that there is a major difference in the attachment of ribosomes to the membranes of the endoplasmic reticulum of secretory and non-secretory tissues, which results in a tissue-specific difference in the vectorial discharge of nascent proteins.


Binding of substrates and modifiers to glucosamine synthetase. 1. The binding of substrates and effectors to glucosamine synthetase (l-glutamine-d-fructose 6-phosphate aminotransferase, EC 2.6.1.16) was studied by using the ligand to alter the denaturation rate of the enzyme. The free enzyme bound fructose 6-phosphate, glucose 6-phosphate and UDP-N-acetylglucosamine, but not glutamine, AMP or UTP. Glucose 6-phosphate and AMP increased the binding of UDP-N-acetylglucosamine whereas UTP decreased the interaction between the enzyme and the feedback inhibitor. UDP-N-acetylglucosamine induced a glutamine-binding site on the enzyme. 2. Selective thermal or chemical denaturation revealed that the UDP-N-acetylglucosamine-binding site was not located at the catalytic site. The UTP site could not be distinguished from that for the nucleotide sugar. The AMP- and glucose 6-phosphate-binding sites were distinct from the catalytic and feedback-inhibitor-binding sites. 3. The specificity of the glutamine-binding site was investigated by using a series of potential analogues. 4. A model is proposed for the action of the effectors and the mechanism of the reaction discussed in kinetic and chemical terms.


Isolation and identification of cytokinins located in the transfer ribonucleic acid of tobacco callus grown in the presence of 6-benzylaminopurine.


Studies of the relationship of proton production and calcification of tendon matrix in vitro.


Photochemical reactions of cytosine nucleosides in frozen aqueous solution in deoxyribonucleic acid.


Inactivation of yeast phenylalanine transfer ribonucleic acid by kethoxal.


A physical study of the stability of the native nucleohistone conformation to salt dissociation and heating.


Purification and kinetic properties of aconitate isomerase from Pseudomonas putida.


Proton magnetic resonance study of high- and low-spin hemin derivatives.


Mechanism of the aconitate isomerase reaction.


Amines as modifiers of the tryptic hydrolysis of neutral substrates.


Vitamin D stimulated calcium binding protein from rat intestinal mucosa. Purification and some properties.


Studies on the fermentation of p-alpha-lysine. On the hydrogen shift catalyzed by the B 12 coenzyme dependent D-alpha-lysine mutase.


Nuclear residual proteins from goose erythroid cells and liver.


Initiation of hemoglobin synthesis. Specific inhibition by antibiotics and bacteriophage ribonucleic acid.


Changes in labeling pattern of ribonucleic acid from mammary tissue as a result of hormone treatment.


Mechanism of prostaglandin biosynthesis. I. Characterization and assay of bovine prostaglandin synthetase.


Partial purification and characterization of the phospholipase A 2  from rat liver mitochondria.


Uterine ribonucleic acid polymerase. Effect of estrogen on nucleotide incorporation into 3' chain termini.


Nature of the binding site of pyridoxal 5'-phosphate to bovine serum albumin.


On self-interacting oligoribonucleotides. I. Absorption and optical rotatory dispersion of 2'-5'- and 3'-5'-oligoguanylic acids.


Gangliosides, glycosidases, and sialidase in the brain and eyes of developing chickens.


Serum levels of prolactin in sheep as measured by radioimmunoassay.


Morphological changes of rat follicular cells as influenced by oocytes.


Cyclical changes of oviduct motility in rabbits.


Effects of fetal, ovarian, and placental weight of various number of fetuses in the rat.


In vitro fertilization of tubal rabbit ova partially or totally denuded of follicular cells.


The penile smear: an index of sexual maturity in male golden hamsters.


Sinus arrest in acute myocardial infarction. The results are given of a 4-year prospective study regarding the occurrence, clinical pattern, and treatment of sinus arrest in patients with acute myocardial infarction. The arrhythmia was observed in 32 of 1665 patients. The detection rate increased from below 1 per cent in the first year to 5 per cent in the last due to better facilities for monitoring. All patients except one had inferior infarction. Paroxysmal atrial fibrillation was observed in 12, corresponding to a frequency approximately similar to that previously reported in patients with sinus arrest unrelated to myocardial infarction. Syncope due to sinus arrest occurred in 7 and hypotension in 19 patients. Small doses of isoprenaline given intravenously were usually effective in restoring normal heart rate, but pacemaker therapy was necessary in 3 patients.


Correlation of mortality rate and serum enzymes in myocardial infarction. Test of efficiency of coronary care.


His bundle electrograms.

His bundle electrograms.


Bradycardia, increased cardiac output, and reversal of pulmonary hypertension in altitude natives living at sea level.


Transseptal catheterization via right subclavian vein.


Persistent ductus arteriosus in Malaysian patients.


"Pixie" cardiography. Accelerometer applications to phonocardiography and displacement cardiography in childhood.


The praecordial honk.

The praecordial honk.


Plasma free fatty acid and catecholamine levels in patients with acute myocardial infarction.


Measurements of sinus impulse conduction from electrogram of bundle of His.


Atrial fibrillation in bacterial endocarditis.


Transposition of great arteries. A study of 65 infants followed for 1 to 4 years after balloon septostomy.


Sinus bradycardia.

Sinus bradycardia.


Traumatic tricuspid regurgitation. Long-term survival.


Electrocardiographic effects of isoprenaline in normal subjects and patients with coronary atherosclerosis.


Myocardial infarction complicating a hydatidiform mole in a young woman.


Systolic time interval fluctuations produced by acute myocardial infarction.


Dysphagia due to left atrial enlargment after mitral Starr valve replacement.


Interrenal type of abdominal aortic coarctation with unusual complications.


Profunda femoral arteriovenous fistula after percutaneous arterial and venous catheterization.


Computers and the anaesthetist.

Computers and the anaesthetist.


Effect of halothane on intracranial pressure gradients in the presence of intracranial space-occupying lesions.


Determination of halothane in gas, blood, and tissues by chemical extraction and gas chromatography.


Cardiovascular collapse after propanidid.


Assisted and controlled ventilation in the newborn period: effect on oxygenation.


Clinical studies of induction agents. XXXIX: CT1341, a new steroid anaesthetic.


A rapid intubation technique for prevention of aspiration during induction of anaesthesia.


Methohexitone and thiopentone. Response to stimuli and incidence of some side effects.


Suxamethonium-induced cardiac arrest in unsuspected pseudohypertrophic muscular dystrophy. Case report.


A puzzling case of cardiac arrest.

A puzzling case of cardiac arrest.


Split-thickness scalp flap for resurfacing full thickness forehead and temporal scalp defects.


Long-term behaviour of preserved homologous rib cartilage in the correction of saddle nose deformity.


The tripartite osteotomy of the mid-face for orbital expansion and correction of the deformity in craniostenosis.


A simple procedure for correction of the hump nose.


Surgical management of large nasal septum perforations.


Pre-auricular fistulae in four generations: a study in heredity.


Median cleft of the lower lip and mandible: a case report.


Planning unilateral breast reduction for asymmetry.


The complications of silastic implants. Experience with 137 consecutive cases.


Beckwith's syndrome.

Beckwith's syndrome.


Hypospadias retractor.

Hypospadias retractor.


Cancer chemotherapy is many things: G.H.A. Clowes Memorial Lecture.


Acute synergistic toxicity and hepatic necrosis following oral administration of sodium nitrite and secondary amines to mice.


Toxicity of aromatic hydrocarbons on normal human epidermal cells in vitro.


Translocation of DNA from the vascular into the nuclear compartment of solid mammary tumors.


Biochemical studies of diethylstilbestrol-induced kidney tumors in the golden Syrian hamster.


Studies on a model immunological system.


A comparison of in vivo and in vitro uptake of estradiol by human breast tumors and the relationship to steroid excretion.


The cell proliferation kinetics of four experimental tumors after acute X-irradiation.


Hyperbasophilic foci as sites of neoplastic transformation in hepatic parenchyma.


Studies on DNA repair in human lymphocytes treated with proximate carcinogens and alkylating agents.


Deoxyribonucleoside incorporation and the role of hydroxyurea in a model lymphocyte system for studying DNA repair in carcinogenesis.


"Preinfarctional" angina. A need for an objective definition and for a controlled clinical trial of its management.


Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema.


Carboxyhemoglobin caused by smoking nonnicotine cigarettes. Effects in angina pectoris.


Sinoatrial-node entrance block.

Sinoatrial-node entrance block.


Conduction through a narrow isthmus in isolated canine atrial tissue. A model of the W-P-W syndrome.


Digoxin metabolism in obesity.

Digoxin metabolism in obesity.


Aortocoronary bypass graft. Initial blood flow through the graft, and early postoperative patency.


Supraventricular tachycardia initiated by sinus beats.


Occurrence of ventricular arrhythmias with exercise as compared to monitoring.


Sites of congenital and surgical heart block as defined by His bundle electrocardiography.


Cholesterol production in obesity.

Cholesterol production in obesity.


Myocardial perfusion imaging with radioactive-labeled particles injected directly into the coronary circulation of patients with coronary artery disease.


Effects of ouabain on impaired left ventricular function during convalescence after acute myocardial infarction.


Silent mitral insufficiency in acute myocardial infarction.


Incidence of myocardial infarction and sudden death from coronary heart disease in Nashville, Tennessee.


Quanitification of left heart volume and systolic output in transposition of the great arteries.


Double-lumen flotation catheter for use in complex congenital cardiac anomalies.


Cardiac surgery in neonates and infants.


Surgical considerations of ventricular septal defect associated with complete transposition of the great arteries and pulmonary stenosis, with special reference to the Rastelli operation.


Virus and the heart.

Virus and the heart.


Right ventricular anomalous muscle bundle.


Ethyl alcohol and the heart.

Ethyl alcohol and the heart.


The effect of prostaglandin E 1  on the pentagastrin-stimulated gastric secretion in man.


The effect of gastric secretory status on jejunal pH measured by radiotelemetering.


Choosing the drug to treat hypertension.


Emergency reduction of blood pressure.

Emergency reduction of blood pressure.


Pimozide (Orap).

Pimozide (Orap).


Sperm-agglutinating and sperm-immobilizing antibodies in vasectomized men.


Spermagglutinating activity in man and guinea pig.


Factors affecting fructose utilization and lactic acid formation by human semen. The role of glucose and pyruvic acid.


Roentgen evaluation of the ligated fallopian tube.


Hysterography study of long-term effects of intrauterine contraceptive devices.


Decidual cell response (DCR) and enzyme activity of the ovary in pseudopregnant rats after administration of antiluteinizing hormone (LH) serum.


Diffusion of progesterone through intrauterine silastic rubber implants.


Use-effectiveness of oral contraceptives by demographic characteristics.


A course for trainees in general practice.


The patient's view of psychiatric treatment.


Referral to hospital.

Referral to hospital.


Anaemia in women factory workers.

Anaemia in women factory workers.


Accidental poisoning in children.

Accidental poisoning in children.


Pulse rates in primigravidae.

Pulse rates in primigravidae.


The Scottish Hospital Centre. The first five years.


Random thoughts about education and training.


Personal points of view. Epidemiological problems in a developing country.


Sociological aspects of dental hospital attendance--a survey of 1000 unselected casual patients.


The Automated reagin Test (ART) for syphilis in a public health laboratory.


A concentration and cultural method for the enhanced isolation of Histoplasma capsulatum from sputum.


Sensitivity of a one-day complement fixation test for detection of hepatitis-associated antigen.


Intersociety committee methods for ambient air sampling and analysis.


Tentative method of analysis of the sulfation rate of the atmosphere (lead dioxide plate methodturbidimetric analysis).


Tentative method for the continuous analysis of total hydrocarbons in the atmosphere (flame ionization method).


Biological dosimetry in an industrial radiography accident.


Body burden, distribution and internal dose of 210Pb and 210Po in a uranium miner population.


Urinary excretion of 241Am under DTPA therapy.


Production of relatively monodisperse aerosols for inhalation experiments by aerosol centrifugation.


Unilateral and bilateral exposure of swine to fission neutrons.


Health physics aspects of 133Xe lung studies.


Estimation of genetically significant dose equivalent from occupational exposure to external sources of radiation in Japan.


Off-site medical planning and management for an experimental underground nuclear detonation.


Exposure rates from the products of thermalneutron fission of 235U at selected times after fission.


Record-keeping in a radiation safety office by timesharing digital computer.


Evaluation of ion-exchange surveillance sampler for analyzing radioactive liquid effluents.


Simplified method of finding quantum radiation energy and its incident direction using a single dosimeter glass.


In-phantom microdosimetry with 14.6 MeV neutrons.


The distribution of radiation exposure within the plane of a circular line source.


Radiation incidents registry--Pennsylvania experience.


Radiation quantities in health physics.

Radiation quantities in health physics.


Strontium levels in Swedish fish.

Strontium levels in Swedish fish.


The analysis of respiratory sinus arrhythmia using spectral analysis and digital filtering.


A new approach to prosthetic control: EEG motor signal tracking with an adaptively designed phase-locked loop.


Transthoracic ventricular defibrillation in the dog with truncated and untruncated exponential stimuli.


Laser Doppler measurements of localized pulsatile fluid velocity.


An electromagnetic system for studying the responses of aquatic organisms to weak electric and magnetic fields.


Phase lock for correlation detection of a periodic pulse.


An automatic curve follower for use with physiological recorders.


Patient electrode isolation adapter.

Patient electrode isolation adapter.


A novel high-performance preamplifier for biological applications.


Improved buffer amplifier for incorporation within a biopotential electrode.


The shifting level in traumatic lipohaemarthrosis.


Topical chemoprophylaxis for burns: trials of creams containing silver sulphadiazine and trimethoprim.


Fat embolism and red-cell aggregation after trauma.


Disaster planning: a review.

Disaster planning: a review.


T- and Y-fractures of the tibial condyles. A follow-up study of cases treated by closed reduction and surgical fixation with a wire loop.


"Pharmacy's lib".

"Pharmacy's lib".


Supply and demand of prescription drugs--1970-1980.


Professionalism--a sociological evaluation of commercialism and inconsistencies in pharmacy.


Professionalism and pharmacy unionism.

Professionalism and pharmacy unionism.


Factors associated with actual and preferred activities of pharmacists.


A community formulary?

A community formulary?