Fibrinolysis induced by factor XII contained in prothrombin preparations.


Relationship between plasma fibrinolytic activity and serum fibrinogen degradation products (FDP) tested by various methods.


A simplified method for preparation of fibrinogen.


Nature of the flagellar beat in Trachelomonas volvocina, Rhabdomonas spiralis, Menoidium cultellus, and Chilomonas paramecium.


Microtrichial polymorphism among hymenolepid tapeworms as seen by scanning electron microscopy.


The arterial system of the planorbid snail Biomphalaria glabrata.


Radiographic technique for detecting cysticercoids in flour beetles.


Trichinella spiralis: aberrant pre-adults.


Chemical modification of viral ribonucleic acid. IX. The effect of ultraviolet irradiation on TMV-RNA and other polynucleotides.


Replication of tobacco mosaic virus. II. The in vitro synthesis of high molecular weight virus-specific RNAs.


Structure and synthesis of a lipid-containing bacteriophage. VII. Structural proteins of bacteriophage PM2.


DNA homology among the T-even bacteriophages.


IUPAC-IUB Commission on Biochemical Nomenclature (CBN). Abbreviations and symbols for nucleic acids, polynucleotides and their constituents. Recommendations (1970).


Mediastinoscopy.

Mediastinoscopy.


Amino acid analysis of the coat protein of the filamentous bacterial virus xf from Xanthomonas oryzae.


Complications of cardiac catheterization.


Treatment of carcinoma of the esophagus.


Familial multiple polyposis: a "curable" disease.


Survival half-time of erythrocytes labeled with  51 Cr in different species of laboratory animals.


A Golgi study of third ventricle tanycytes in the adult rodent brain.


The structure of the terminal sensilla on the maxillary palps of Locusta migratoria (L.), and changes associated with moulting.


The effects of osmotic experiments and prolactin on the mucous cells in the skin and the ionocytes in the gills of the teleost Cichlasoma biocellatum.


Studies on an extracellular polysaccharide from Rhizobium meliloti.


Membrane-bound inorganic pyrophosphatase of human erythrocytes.


Influence of hydrophobic interactions and hydration on the radiosensitivity of a protein.


Studies on the coupling step in solid phase peptide synthesis. Some preliminary results from competition experiments.


A new amylolytic enzyme.

A new amylolytic enzyme.


The content of trans-aconitic acid in Asarum europaeum L. determined by means of a chromatogram spectrophotometer.


Carotenoids of higher plants. 5. Total synthesis of lycoxanthin.


Anomeric nature of the D-mannose residues in the Salmonella typhi and S. strasbourg lipopolysaccharides.


Ano-rectal Crohn's disease.

Ano-rectal Crohn's disease.


A case of hepatic adenoma.

A case of hepatic adenoma.


Morphologic peculiarities of anaplastic cerebellar tumors and their prognostic significance.


Histotopography of the glandular areas of the gastric mucosa. I. The pyloric gland area in patients with duodenal ulcer.


Histotopographic studies on the glandular area of the gastric mucosa. II. The intermediate part in patients with duodenal ulcer.


Microdensitometric analysis of the influence of x-irradiation on mature bone in humans.


The apexocardiogram in acquired cardiac defects.


An experimental model of micronecrosis in the myocardium in rats.


Electrolyte barrier and histologic pattern of the gastric mucosa in man.


Leukemias in the Cracow region in the years 1961-1968.


Encephalopathia pugilistica (punch drunkeness).


Psychopathology in alpinism.

Psychopathology in alpinism.


A year's experience of L-DOPA in the treatment of Parkinson's disease.


Intraventricular pressure after administration of dehydrating agents to severely brain-injured patients: is there a rebound phenomenon?


Myoepithelial cells in the exorbital lacrimal and parotid glands of the rat in frozen-etched replicas.


Communicating syringomyelia presenting immediately after trauma. A case description and some theoretical concepts.


Influence of bile and pancreatic secretions on the size of the intestinal villi in the rat.


The vertebral-basilar system of dog in relation to man and other mammals.


Joint capsule collagen. Analysis by the study of intra-articular pressure during joint distension. Measurements in the knees of control subjects and patients with rheumatoid arthritis and Ehlers-Danlos syndrome.


Chromosomal studies in patients taking phenylbutazone.


Effects of prednisolone in an experimental model of arthritis in the rabbit.


Destructive lesions of vertebral bodies in ankylosing spondylitis.


Cell-mediated immunity to micro-organisms in rheumatoid arthritis.


Plasma lipid levels and platelet adhesiveness in gout.


Scanning electron microscopy and replica studies of joint surfaces in experimental arthritis.


Optimal resources for cardiac surgery. Report of the Inter-Society Commission for Heart Disease Resources.


Autologous fascia lata valves in combined aortic and mitral valve replacement.


Experimental percutaneous mitral commissurotomy.


Mechanical support of the circulation by a modified pulsatile roller pump.


Electron microscopy and thermal analysis of neointima heated and irradiated in vivo for two years.


Strangulating diaphragmatic hernia.

Strangulating diaphragmatic hernia.


Spontaneous perforation of the esophagus.


Ectopic liver. A cause of esophageal obstruction.


Conservative management of infected pacemaker pulse generator sites.


Report of the surgery study group of the I.C.H.D.


Electromyelometry. An approach to the problem of quantitative supravital examination of the bone marrow. I. Experimental trials.


A synthetic iodinated polypeptide that inhibits polymerization of fibrinogen.


Chromosomal abnormalities in lymphocytes of children and baby rabbits born from mothers treated by x-radiation before pregnancy. A transplacentary plasmatic chromosome-damaged factor?


Organization of the turtle thalamus: visual, somatic and tectal zones.


The central projections of the olfactory bulb in a teleost (Gymnothorax funebris).


A. Perstans and W. Bancrofti. A filarial survey in a game reserve in the zambezi valley.


Zinc: human nutrition and metabolic effects.


Avila Mission Hospital.

Avila Mission Hospital.


Hycanthone: contraindications to its use.


Mpilo Hospital case report. A case of sarcoidosis in an african.


Management of incomplete abortion as an outpatient procedure. To alleviate crowding in the gynecological wards, 350 of 410 cases of incomplete abortion seen between February and July, 1969, were treated as outpatients with analgesia instead of anesthesia.  Patients with sepsis, severe anemia, septicemia or hypovolaemic shock, or who aborted as a result of serious illness were treated as inpatients.  74.4% of the patients were discharged within 12 hours.  Paracervical block in combination with pethidine and valium administered intravenously or premedication with pethidine was more effective than paracervical block alone.


Meningitic anthrax.

Meningitic anthrax.


Acute bacterial meningitis in childhood.


The elongated shadow.

The elongated shadow.


A critical appraisal of contemporary psychiatry.


Preventive psychiatry in the general hospital.


Effect of lithium citrate on adrenocortical activity in manic-depressive illness.


The influence of prophylatic lithium treatment on the marital adjustment of manic-depressives and their spouses.


Depressive disease: classification and clinical characteristics.


Chronobiologic approaches in clinical psychiatry.


The ratio of total recoverable memories to conscious memories in normal subjects.


Mechanisms of family homeostasis.

Mechanisms of family homeostasis.


Lipoid proteinosis in South Africa.

Lipoid proteinosis in South Africa.


Erythrokeratodermia congenitalis progressiva symmetrica (Gottron). II. An analysis of kinetics of epidermal cell proliferation.


Subcutaneous Trichophyton rubrum abscesses. A case report.


Alternate-day corticosteroid regimen.

Alternate-day corticosteroid regimen.


Ultrastructural changes in the gastric mucosa after truncal vagotomy.


Intraoperative cardiothermography. A new method for detecting ischemic areas in the heart muscle and for investigating the results of revascularization procedures in coronary surgery.


Editorial.

Editorial.


Observations on the treatment of some fractures of the forearm by splintage that does not include the elbow.


The training of an accident surgeon.

The training of an accident surgeon.


Reconstruction for old rupture of the anterior cruciate ligament. A follow-up study.


Prosthetic replacement after femoral neck fractures (short-and long-term follow-up).


Prosthetic replacement for subcapital fractures of the femur: a comparative survey.


Fat embolism and oxygen therapy.

Fat embolism and oxygen therapy.


Resolution in electron microscope radioautography. II. Carbon 14. Experimental resolution values, half distances (HD), were determined for electron microscope radioautography with (14)C as the source of radioactivity. These were about a factor of 1.5-2 times higher than for tritium. Grain distributions normalized in units of HD were found to fit the "universal" curves previously obtained for tritium.


Spindles, spindle plaques, and meiosis in the yeast Saccharomyces cerevisiae (Hansen). The intranuclear spindle of yeast has an electron-opaque body at each pole. These spindle plaques lie on the nuclear envelope. During mitosis the spindle elongates while the nuclear membranes remain intact. After equatorial constriction there are two daughted nuclei, each with one spindle plaque. The spindle plaque then duplicates so that two side-by-side plaques are produced. These move rapidly apart and rotate so that they bracket a stable 0.8 microm spindle. Later, during mitosis, this spindle elongates, etc. Yeast cells placed on sporulation medium soon enter meiosis. After 4 hr the spindle plaques of the more mature cells duplicate, producing a stable side-by-side arrangement. Subsequently the plaques move apart to bracket a 0.8 microm spindle which immediately starts to elongate. When this meiosis I spindle reaches its maximum length of 3-5 microm, each of the plaques at the poles of the spindle duplicates and the resulting side-by-side plaques increase in size. The nucleus does not divide. The large side-by-side plaques separate and bracket a short spindle of about 1 microm which elongates gradually to 2 or 3 microm. Thus there are two spindles within one nucleus at meiosis II. To the side of each of the four plaques a bulge forms on the nucleus. The four bulges enlarge while the original nucleus shrinks. These four developing ascospore nuclei are partially surrounded by cytoplasm and by a prospore wall which originates from the cytoplasmic side of the spindle plaque. Eventually the spore nuclei pinch off and the spore wall closes. In some of the larger yeast cells this development is completed after 8 hr on sporulation medium.


Effect of pancreozymin on rat pancreatic enzyme biosynthesis. Pancreatic enzyme secretion in rats anesthesized by pentobarbital was stimulated by intravenous perfusion of the hormone pancreozymin, as indicated by a decreased amylase level in the pancreas and by specific, fine structural changes observed in an electron microscope. Rates of protein synthesis were determined by pulse labeling. Amylase, total protein, and valine were purified from pancreas and counted. Pancreozymin promotes an 8 to 10 times increase in the rate of biosynthesis of pancreatic enzymes, as compared to rats similarly anesthesized but without hormone. This stimulation effect is obtained very rapidly (2 hr) and is not inhibited by actinomycin D. Secretin alone has no effect, whereas pentobarbital is inhibitory.


Effects of non-linearities on the television display of x-ray images.


Kinetoplast and other satellite DNAs of kinetoplastic and dyskinetoplastic strains of Trypanosoma.


Sulfate metabolism in pancreatic acinar cells. The metabolism of inorganic sulfate in pancreatic acinar cells was studied by electron microscope radioautography in mice injected with sulfate-(35)S. Labeled sulfate was concentrated in the Golgi complex at 10 min. Within 30 min, much of the radioactive material had been transferred to condensing vacuoles. These were subsequently transformed into zymogen granules. By 4 hr after injection, some of the zymogen granules with radioactive contents were undergoing secretion, and labeled material was present in the pancreatic duct system. The Golgi complex in pancreatic acinar cells is known to be responsible for concentrating and packaging digestive enzymes delivered to it from the endoplasmic reticulum. Our work demonstrates that the Golgi complex in these cells is also engaged in the manufacture of sulfated materials, probably sulfated mucopolysaccharides, which are packaged along with the enzymes in zymogen granules and released with them into the pancreatic secretion.


Cell injury and cell regeneration in selective renal arteriography in rabbits. A preliminary report.


Corss-bridges on the microtubules of cooled interphase HeLa cells.


Reflux pancreatography. Experimental observations in the cat.


Nucleolar-derived ribonucleic acid in chromosomes, nuclear sap, and cytoplasm of Chironomus tentans salivary gland cells. The distribution of monodisperse high molecular weight RNA (38, 30, 28, 23, and 18S RNA) was studied in the salivary gland cells of Chironomus tentans. RNA labeled in vitro and in vivo with tritiated cytidine and uridine was isolated from microdissected nucleoli, chromosomes, nuclear sap, and cytoplasm and analyzed by electrophoresis on agarose-acrylamide composite gels. As shown earlier, the nucleoli contain labeled 38, 30, and 23S RNA. In the chromosomes, labeled 18S RNA was found in addition to the 30 and 23S RNA previously reported. The nuclear sap contains labeled 30 and 18S RNA, and the cytoplasm labeled 28 and 18S RNA. On the basis of the present and earlier analyses, it was concluded that the chromosomal monodisperse high molecular weight RNA fractions (a) show a genuine chromosomal localization and are not due to unspecific contamination, (b) are not artefacts caused by in vitro conditions, but are present also in vivo, and (c) are very likely related to nucleolar and cytoplasmic (pre)ribosomal RNA. The 30 and 23S RNA components are likely to be precursors to 28 and 18S ribosomal RNA. The order of appearance of the monodisperse high molecular weight RNA fractions in the nucleus is in turn and order: (a) nucleolus, (b) chromosomes, and (c) nuclear sap. Since both 23 and 18S RNA are present in the chromosomes, the conversion to 18S RNA may take place there. On the other hand, 30S RNA is only found in the nucleus while 28S RNA can only be detected in the cytoplasm, suggesting that this conversion takes place in connection with the exit of the molecule from the nucleus.


Transcatheter embolization with a silicone rubber preparation. Experimental observations.


Changes in the sarcoplasmic reticulum and transverse tubular system of fast and slow skeletal muscles of the mouse during postnatal development. The sarcoplasmic reticulum (SR) and transverse tubular system (TTS) of a fast-twitch muscle (extensor digitorum longus-EDL) and a slow-twitch muscle (soleus-SOL) of the mouse were examined during postnatal development. Muscles of animals newborn to 60 days old were fixed in glutaraldehyde and osmium tetroxide and examined with an electron microscope. At birth the few T tubules were often oriented longitudinally, but at the age of 10 days most of them had a transverse orientation. In the EDL, the estimated volume of the TTS increased from 0.08% at birth to 0.4% in the adult; corresponding values for the SOL were 0.04% at birth and 0.22% in the adult. A similar relative change was observed in surface area of the TTS during development. Calculated on the basis of a 30 microm diameter fiber, the surface area of the TTS in the EDL increased from 0.60 cm(2) TTS/cm(2) fiber surface in the newborn to 3.1 cm(2)/cm(2) in the adult, compared with 0.15 cm(2)/cm(2) at birth to 1.80 cm(2)/cm(2) in the adult for the SOL. The SR in the newborn muscles occurred as a loose network of tubules that developed rapidly within the subsequent 20 days, especially at the I band level. The volume of the SR increased in the EDL from 1.1% of fiber volume at birth to 5.5% in the adult. In the SOL the change was from 1.7% to 2.9%. The SOL approached the adult values more rapidly than the EDL, although the EDL had more SR and T tubules. Fibers of both EDL and SOL muscles showed variation in Z line thickness, mitochondrial content, and diameter, but over-all differences between the two muscles in amount of SR and TTS were significant. It is considered that the differing amounts of SR and TTS are closely related to the differing speeds of contraction that have been demonstrated for these two muscles.


Erythroid cell differentiation and the inhibition of cytokinesis by cytochalasin. Cytochalasin B produces multinucleated erythroid cells in tissue cultures of very young chick blastoderms. There is no apparent qualitative interference with differentiation and maturation of erythroid cells, but the amounts produced are reduced 4- and 10-fold. These effects of cytochalasin are readily reversible.


Morphological and biochemical changes in rat synaptosome fractions during neonatal development. A biochemical and quantitative morphologic study of presynaptic endings during postnatal development was carried out in subcellular fractions from cerebral cortex of 1, 4, 8, 12, and 18 day old and adult rats. Crude mitochondrial fractions were subfractionated in Ficoll gradients and all resulting fractions were examined in the electron microscope. Presynaptic terminals and other intact processes were counted. Protein content and enzyme activities were assayed in the fractions and in total brain homogenate. In the first and fourth day of life, most of the presynaptic terminals were found in two "light" fractions, between supernatant and 7.5% Ficoll, where they accounted, respectively, for 6 and 22% of all the processes. Progressively with age, more presynaptic terminals were found in the traditional "synaptosomal" fractions between 7.5 and 13% Ficoll. In that region of the gradient, 40, 54, 75, and 89% of the processes were presynaptic endings at 8, 12, and 18 postnatal days and in the adult animal, respectively. A similar shift from the lighter to the heavier fractions was observed in the distribution of choline acetyltransferase and acetylcholinesterase between days 8 and 12. The rate of increase of the specific activity of these two enzymes paralleled that of the percentage of the presynaptic endings after day 8. This study indicates that subcellular fractions can be used to study formation and maturation of synapses during postnatal development.


Effects of ethidium bromide on the cytochrome content and ultrastructure of L cell mitochondria. Ethidium bromide intercalates between the bases of native DNA, resulting in several biological anomalies. The effects of ethidium bromide on the mitochondria of cultured mouse L cells were studied. At a concentration of 1 microg ethidium bromide/ml it was observed that concentrations of cytochromes a + a(3) and b decreased, a + a(3) more rapidly than b. In contrast, the concentration of cytochromes c(1) and c increased or remained the same as in control cells. Concomitant with the decrease of cytochromes a + a(3) and b was an enlargement of the mitochondria and a reduction in the cristae. The cristae that remained were abnormally organized. After prolonged treatment with ethidium bromide a second population of small, more normally organized mitochondria was apparent. These effects of ethidium bromide could be reversed.


The isolation and partial characterization of the pyrenoid protein of Eremosphaera viridis. The pyrenoids of Eremosphaera viridis, a green alga, were isolated by density gradient centrifugation and their physical and enzymatic properties were studied. The ultraviolet absorption spectrum of sodium dodecyl sulfate (SDS) extracts of pyrenoids showed a single peak at a wavelength of 277 nm, indicating the presence of protein and the probable absence of nucleic acid. Upon electrophoresis on polyacrylamide gels containing SDS, 16 bands were resolved of which two, together, accounted for 90% of the total protein on the gels. The molecular weights of these two proteins were estimated to be 59,000 and 12,300 and the ratio by weight of the larger to the smaller protein was found to be 2:1. The physical and enzymatic properties of these two proteins were found to closely resemble the properties reported in the literature for the subunits of fraction I protein. Both pyrenoids and fraction I protein are localized in the chloroplast, and both have two principal protein components. The molecular weights and relative ratio of the two pyrenoid components are very similar to those of the two components of fraction I protein. The pyrenoid was found to contain a high specific activity of ribulose-1,5-diphosphate carboxylase which is the same enzymatic activity exhibited by fraction I protein. The presence of ribose-5-phosphate isomerase and ribulose-5-phosphate kinase activities was also noted in pyrenoid preparations. It is suggested that the pyrenoid contains fraction I protein and possibly other enzymes of the Calvin-Bassham carbon dioxide fixing pathway.


Demonstration of a colcemid-sensitive attractive force acting between the nucleus and a center.


Malnutrition: incorporation of thymidine-3H into nuclear and mitochondrial DNA.


The response of duck erythrocytes to nonhemolytic hypotonic media. Evidence for a volume-controlling mechanism. Duck erythrocytes were incubated in hypotonic media at tonicities which do not produce hemolysis. The cells' response can be divided into two phases: an initial rapid phase of osmotic swelling and a second more prolonged phase (volume regulatory phase) in which the cells shrink until they approach their initial isotonic volume. Shrinkage associated with the volume regulatory phase is the consequence of a nearly isosmotic loss of KCl and water from the cell. The potassium loss results from a transient increase in K efflux. There is also a small reduction in Na permeability. Changes in cell size during the volume regulatory phase are not altered by 10(-4)M ouabain although this concentration of ouabain does change the cellular cation content. The over-all response of duck erythrocytes is considered as an example of "isosmotic intracellular regulation," a term used to describe a form of volume regulation common to euryhaline invertebrates which is achieved by adjusting the number of effective intracellular osmotic particles. The volume regulatory phase is discussed as the product of a membrane mechanism which is sensitive to some parameter associated with cell volume and is capable of regulating the loss of potassium from the cell. This mechanism is able to regulate cell size when the Na-K exchange, ouabain-inhibitable pump mechanism is blocked.


The response of duck erythrocytes to hypertonic media. Further evidence for a volume-controlling mechanism. The addition of a hypertonic bathing medium to duck erythrocytes results in an initial instantaneous phase of osmotic shrinkage and, when the [K](o) of the hypertonic solution is larger than "normal," in a second, more prolonged phase, the volume regulatory phase. During the latter, which also requires extracellular Na, the cells swell until they approach their initial isotonic volume. The increase in cell volume during the volume regulatory phase is accomplished by a gain in the cell content of K, Cl, and H(2)O. There is also a smaller increase in the Na content of the cell. Potassium is accumulated against an electrochemical gradient and is therefore actively transported into the cell. This accumulation is associated with an increase, although dissimilar, in both K influx and efflux. Changes in cell size during the volume regulatory phase are not altered by 10(-4)M ouabain, although this concentration of ouabain does change the cellular cation content. The response is independent of any effect of norepinephrine. The changes in cell size during the volume regulatory phase are discussed as the product of a volume controlling mechanism identical in principle to the one reported in the previous paper which controls cell volume in hypotonic media. Similarly, this mechanism can regulate cell size, when the Na-K exchange, ouabain-inhibitable pump mechanism is blocked.


Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. A number of compounds related to TEA(+) (tetraethylammoniumion) were injected into squid axons and their effects on g(K) (the potassium conductance) were determined. In most of these ions a quaternary nitrogen is surrounded by three ethyl groups and a fourth group that is very hydrophobic. Several of the ions cause inactivation of g(K), a type of ionic gating that is not normally seen in squid axon; i.e., after depolarization g(K) increases and then spontaneously decreases to a small fraction of its peak value even though the depolarization is maintained. Observations on the mechanism of this gating show that (a) QA (quaternary ammonium) ions only enter K(+) channels that have open activation gates (the normal permeability gates). (b) The activation gates of QA-occluded channels do not close readily. (c) Hyperpolarization helps to clear QA ions from the channels. (d) Raising the external K(+) concentration also helps to clear QA ions from the channels. Observations (c) and (d) strongly suggest that K(+) ions traverse the membrane by way of pores, and they cannot be explained by the usual type of carrier model. The data suggest that a K(+) pore has two distinct parts: a wide inner mouth that can accept a hydrated K(+) ion or a TEA(+)-like ion, and a narrower portion that can accept a dehydrated or partially dehydrated K(+) ion, but not TEA(+).


Active sodium and potassium transport in high potassium and low potassium sheep red cells. The kinetic characteristics of the ouabain-sensitive (Na + K) transport system (pump) of high potassium (HK) and low potassium (LK) sheep red cells have been investigated. In sodium medium, the curve relating pump rate to external K is sigmoid with half maximal stimulation (K(1/2)) occurring at 3 mM for both cell types, the maximum pump rate in HK cells being about four times that in LK cells. In sodium-free media, both HK and LK pumps are adequately described by the Michaelis-Menten equation, but the K(1/2) for HK cells is 0.6 +/- 0.1 mM K, while that for LK is 0.2 +/- 0.05 mM K. When the internal Na and K content of the cells was varied by the PCMBS method, it was found that the pump rate of HK cells showed a gradual increase from zero at very low internal Na to a maximum when internal K was reduced to nearly zero (100% Na). In LK cells, on the other hand, no pump activity was detected if Na constituted less than 70% of the total (Na + K) in the cell. Increasing Na from 70 to nearly 100% of the internal cation composition, however, resulted in an exponential increase in pump rate in these cells to about (1/6) the maximum rate observed in HK cells. While changes in internal composition altered the pump rate at saturating concentrations of external K, it had no effect on the apparent affinity of the pumps for external K. These results lead us to conclude that the individual pump sites in the HK and LK sheep red cell membranes must be different. Moreover, we believe that these data contribute significantly to defining the types of mechanism which can account for the kinetic characteristics of (Na + K) transport in sheep red cells and perhaps in other systems.


Physiological studies during formation and development of rat neuromuscular junctions in tissue culture. Developing neuromuscular junctions in tissue cultures of rat embryo spinal cord and muscle were studied with intracellular recording. Excitatory junctional potentials (ejps) were found during nerve or spinal cord stimulation, and also arising spontaneously. The time-course of the potentials tended to be shorter in cultures older than 9 days in vitro than in more recently innervated cultures. Evidence of multiple innervation was found in many cells. In order to test the hypothesis that transmitter was released in integral multiples of a quantal amount and according to a Poisson distribution, mean quantum content was calculated from the coefficient of variation of ejp amplitudes, the percentage of zero responses, and the ratio of mean amplitude to mean of the smallest class of amplitudes. The three independent measures were in fair or good mutual agreement, implying that the mechanism of transmitter release in newly developed junctions is the same as in the adult. In newly formed junctions, ejps were subthreshold for action potential generation, but afterwards mean quantum content increased and action potentials were generated by single ejps. In fibers developing both with and without innervation, the entire muscle cell surface was as sensitive to acetylcholine as the adult end plate region. Innervation was related to cross-striation: every cross-striated fiber tested was found to be innervated, and denervation in vitro led to loss of distinct cross-striations.


Unilateral cervicothoracic sympathetic ganglionectomy for the treatment of long QT interval syndrome.


Salivary electrolytes in the detection of digitalis toxicity.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 41-1971.


Digitalis assay by salivary electrolytes.


Does delivery by section matter to the infant?


Measuring the quality of health care.

Measuring the quality of health care.


Tuberculosis and the new citizen.

Tuberculosis and the new citizen.


Adenocarcinoma of vagina.

Adenocarcinoma of vagina.


Factitiously low ESR with chronic lymphocytic leukemia.


On large and small platelets.

On large and small platelets.


Mycoplasma pneumonia.

Mycoplasma pneumonia.


Absorption of digitalis compounds.

Absorption of digitalis compounds.


Changes in ribosomes from neonatal animal lung following 98 percent oxygen exposure.


Ceruloplasmin variants in mouse serum.

Ceruloplasmin variants in mouse serum.


Some effects of concanavalin A on tumorigenesis in mice.


Modern methods for analysis of psychoactive drugs and metabolites.


Chemistry and pharmacology of the benzodiazepines.


Symposium on pediatric nephrology. Foreword.


Effect of protein synthesis inhibitors on the formation of crystalloid inclusions in the endoplasmic reticulum of beetroot cells.


Continuity between cytoplasmic endomembranes and outer mitochondrial membranes in fungi.


Connections between mitochondria and endoplasmic reticulum in rat liver and onion stem.


Cytology of beet yellows virus infection in Tetragonia. 3. Conformations of virus in infected cells.


The fine structural distribution of acid phosphatase in the digestive gland of Arion hortensis (Fer.).


Evaluation of acute alcoholic psychoses and related states. The daily clinical course rating scale.


Outpatient treatment of alcoholics. Effects of status, stability and nature of treatment.


The Fort Meade alcoholism treatment program. A follow-up study.


Four-year follow-up of alcoholics treated at a rural state hospital.


Sex differences in patient attitudes toward alcoholism treatment.


A communications approach to alcoholism.


Birth order and failure. The evidence from Skid Row.


Children of alcoholics. Observations in a child guidance clinic.


Dimensions of alcoholism.

Dimensions of alcoholism.


The language of "drunks".

The language of "drunks".


The epidemiology of alcoholic cirrhosis in two southwestern Indian tribes.


Blood ethanol levels following rapid intravenous infusion.


Ethical resk-taking among alcoholics.

Ethical resk-taking among alcoholics.


Effect of alcohol on the psychological refractory period.


Blood alcohol levels in drivers not involved in accidents and the lognormal distribution.


Postpartum services in family planning: findings to date.


Oxygen transport in the llama (Lama glama).


Inhomogeneity effects on O 2  and CO pulmonary diffusing capacity estimates by steady-state methods. Theory.


Autoregulation of blood flow in the carotid body.


The responses of carotid body chemoreceptors in the cat to sudden changes of hypercapnic and hypoxic stimuli.


Effects of acute through life-long hypoxic exposure on exercise pulmonary gas exchange.


Adaptive value of a reduced respiratory metabolism in a lizard. A unique case.


Spontaneous rupture of the splenic artey at the level of an atheromatous plaque.


Acute hemiplegia of childhood with total occlusion of the internal carotid artery (supra-clinoid); a case report.


Paraplegia following infrarenal aneurysmorrhaphy.


Anomalous origin of the right coronary artery.


Infections of vascular anastomoses.

Infections of vascular anastomoses.


The late postoperative occurrence of cardiac tamponade in the open heart patient: report of three cases.


Bone formation and resorption in cases of delayed union and pseudarthrosis.


AOI osteosynthesis of fractures of the distal third of the femur.


Sub-periosteal ganglia.

Sub-periosteal ganglia.


Effect of acute temperature change in some renal functions in sickle cell disease.


Total plasma osmolality in the management of acute gastro-enteritis in Nigerian children.


Lack of diurnal variations in sodium, potassium and osmolal excretion in the sickle cell patient.


Renal response to salt load in normotensive and hypertensive Nigerian males.


The prison diet research project.

The prison diet research project.


3-phosphoglycerate kinase (E.C.2.7.2.3) from human liver.


Computer assisted arrhythmia identification.


Action of catecholamines on nerve induced salivation in the rat.


A study of the effects of chloroquine as an inhibitor of in vitro mitochondrial respiration.


Fingernail samples as "tissue biopsies" in the study of neonatal body composition and nutrition (newborn).


There are some hopeful signs.

There are some hopeful signs.


Honors Convocation Address--School of Dentistry.


Hepatic uptake of organic anions during toxic injury by dimethylnitrosamine.


The ring 18 syndrome--a rare autosomal aberration.


Alteration of thyroid function tests by hemodialysis--an effect of heparin.


Sexual problems in children and adolescents.


Spider angiomata in endocarditis.

Spider angiomata in endocarditis.


Behavior therapy--a new tool.

Behavior therapy--a new tool.


Student dental health program of the University of Alabama in Birmingham. IV. Enrollment and utilization.


Neuromyelitis optica: a case report with reappraisal of its relation to multiple sclerosis.


Anthropometric identity of Alabama Shell-Mound people c10,000 BC, Polynesians, Pelasgians and Fomorians.


Leucine aminopeptidase in biliary and pancreatic obstruction and other metabolic disorders.


Student dental health program of the University of Alabama in Birmingham. V. Services.


Serum alkaline phosphatase, chemical syndromes, glycoprotein and other diseases intercorrelated.


Disease and chemical syndromes associated with serum levels of glucosyl transferases.


The effect of noxious vapors on embryonic chick development.


Summary of periodontal disease session.

Summary of periodontal disease session.


The value of science youth activities.

The value of science youth activities.


The challenge of prevention in dentistry.


Brief psychotherapy with children: process of therapy.


Psychiatric evaluations for young men facing the draft: a report of 147 cases.


"Coffee and": a way to treat the untreatable.


Emergency psychiatric ambulance services in the USSR.


A comparison of some aspects of structured and unstructured psychiatric interviews.


The evolving health care delivery system and hospital pharmacy.


"What kind of vaccine"?

"What kind of vaccine"?


The Journal of the Philadelphia College of Pharmacy in 1831.


Laboratory quality assurance program.

Laboratory quality assurance program.


The fixed professional fee.

The fixed professional fee.


Marijuana use by GIs in Viet Nam.

Marijuana use by GIs in Viet Nam.


Postoperative reactions in children: "normal" and abnormal responses after cardiac surgery.


Marijuana use by medical students.

Marijuana use by medical students.


Legalization of marijuana: pros and cons.


Hallucinogenic effects of marijuana as currently used.


Marijuana and health.

Marijuana and health.


Clinical measure of enforced group psychotherapy.


Group rounds versus individual medical rounds on a psychiatric inpatient service.


Mortality following a psychiatric emergency room visit: an 18-month follow-up study.


Foreign certification in psychiatry.

Foreign certification in psychiatry.


"Fee for service" from the poor.

"Fee for service" from the poor.


Pseudo-therapeutic benefits from an adverse social phenomenon (racial prejudice).


The APA's self-assessment examination.

The APA's self-assessment examination.


Do you use salt?

Do you use salt?


Methylphenidate: a catalyst for the tricyclic antidepressants?


The relationship of normetanephrine and metanephrine levels to DMPEA urinary excretion levels.


Marijuana and alcohol: harmful effects.

Marijuana and alcohol: harmful effects.


The role of the school nurse in health education.


An analysis of the demand for emergency ambulance service in an urban area.


"Preventive medicine"?

"Preventive medicine"?


A comparative study of four dental payment mechanisms in a Head Start program.


New dental care concepts: perceptions of dentists and dental students.


Poverty area residents look at pharmacy services.


The pharmacist as a member of the health team.


Employee protest and social change in the health care organization.


Neighborhood health centers.

Neighborhood health centers.


Councils of governments as the areawide comprehensive health planning agency.


Seasonal patterns of conception in New York City.


Health aspects of water quality.

Health aspects of water quality.


Health aspects of toxic materials in drinking water.


Trends in laser applications: public health implications.


The place of nutrition in the health education curriculum.


A preliminary evaluation of a School of Public Health through its physician graduates.


New look at basic radiation standards.

New look at basic radiation standards.


Training of comprehensive health planners.


Public health and the law: a National Commission on Medical Malpractice.


The epidemiologic rationale for the failure to eradicate measles in the United States.


The diurnal dynamics of DNA synthesis in cells of the thoracic duct wall. Autoradiographic study.


Ergotamine gangrene in various inflammatory conditions.


Studies on plant growth-regulating substances. XXXII. Chlorosubstituted  -hydroxy- and  -methoxy-phenylacetic acids.


A mechanochemical model of flagellar activity. A theory is presented which quantitatively links the physical properties of a flagellum with parameters which characterize the chemical reactions responsible for deforming the flagellum. Realistic values for the wave parameters are predicted when order-of-magnitude values for the appropriate constants are used. The model may be useful in other fields where mechanochemical coupling occurs.


A stored charge model for the sodium channel. A new model is proposed to account for the apparent conductance changes of the sodium, or early, channel in nerve fiber membranes. In this model it is assumed that the channels are gated at the interior side of the membrane and are resistively limited at the exterior side by sodium selective barriers of high resistance to ion flow. Under resting conditions the closed channels accumulate a store of sodium ions, dependent on the exterior sodium concentration. With the application of a depolarizing clamp the interior gates open allowing the stored ions to discharge into the interior low sodium concentration solution. In this model the initial rise in the early current results from the opening of more and more gates in response to the depolarizing clamp. The subsequent fall in the early current results from the "capacitative" discharge of the opened channels, limited by the high resistive barrier at the exterior end. Upon repolarization, the gates reclose and sodium ions reaccumulate in the channels from the high concentration external solution, but at a slow rate determined by the resistive barrier. Preliminary tests of this model, using a number of simplifying assumptions, show that it has the ability to account, at least semiquantitatively, for the major characteristics of the experimental clamp results.


A model of respiratory heat transfer in a small mammal. A steady-state model of the heat and water transfer occurring in the upper respiratory tract of the kangaroo rat, Dipodomys spectabilis, is developed and tested. The model is described by a steady-state energy balance equation in which the rate of energy transfer from a liquid stream (representing the flow of heat and blood from the body core to the nasal region) is equated with the rate of energy transfer by thermal conduction from the nose tip to the environment. All of the variables in the equation except the flow rate of the liquid stream can be either measured directly or estimated from physiological measurements, permitting the solution of the equation for the liquid stream flow rate. After solving for the liquid stream flow rate by using data from three animals, the energy balance equation is used to compute values of energy transfer, expired air temperature, rates of water loss, and efficiency of vapor recovery for a variety of ambient conditions. These computed values are compared with values measured or estimated from physiological measurements on the same three animals, and the equation is thus shown to be internally consistent. To evaluate the model's predictive value, calculated expired air temperatures are compared with measured expired air temperatures of eight additional animals. Finally, the model is used to examine the general dependence of expired air temperature, of rates of water loss, and of efficiency of vapor recovery on ambient conditions.


The kinetics of selective biological transport. V. Further data on the erythrocyte-monosaccharide transport system. Measurements of the rate of loss of sugar from human erythrocytes into sugar-free solutions were made as a function of sugar concentrations. The half-saturation concentration of this process was found to be different from those half-saturation concentrations previously measured by other methods. These data, together with a number of similar data from former publications, are summarized in tabular form and their use in assessing postulated transport mechanisms is illustrated by consideration and rejection of a mechanism in which the transport process is assumed to be the result of a protein conformational change.


Passive asymmetric transport through biological membranes. The magnitude of passive diffusional solute transfer through artificial membranes is usually considered to be independent of the direction of the concentration gradient driving force. It can be shown, however, that a composite membrane, having as one component a membrane with a chemical reaction-facilitated diffusion transport mechanism, can result in an asymmetrical flux. An asymmetric flux caused by this type of structural heterogeneity may be one mechanism contributing to the asymmetric properties of biological membranes. Similar vectorial fluxes can be generated in interfacial solute transfer through membranes if hydrodynamic boundary layers occur at the membrane interface and reversible chemical reactions with the permeant species are involved in either phase.


Direct effects on the membrane potential due to "pumps" that transfer no net charge. The effects of active ionic transport are included in the derivation of a general expression for the zero current membrane potential. It is demonstrated that an active transport system that transfers no net charge (nonrheogenic) may, nevertheless, directly alter the membrane potential. This effect depends upon the exchange of matter within the membrane between the active and passive diffusion regimes. Furthermore, in the presence of such exchange, the transmembrane active fluxes measured by the usual techniques and the local pumped fluxes are not identical. Several common uses of the term "electrogenic pump" are thus shown to be inconsistent with each other. These inconsistencies persist when the derivation is extended to produce a Goldman equation modified to account for active transport; however, that equation is shown to be limited by less narrow constraints on membrane heterogeneity and internal electric field than those previously required. In particular, it is applicable to idealized mosaic membranes limited by these requirements.


The relationship between cell growth and generation time.


Reactivity of purine and pyrimidine bases toward singlet oxygen.


Application of neural network models.

Application of neural network models.


Quantitative measurement of 1-f noise and membrane theory.


The murmuring heart.

The murmuring heart.


Clarity and confusion in active chronic hepatitis.


Solar flares and the Concorde.

Solar flares and the Concorde.


New antibacterial drugs.

New antibacterial drugs.


Anticoagulant interactions.

Anticoagulant interactions.


Science for pleasure or science for profit?


Sudden death in hospital after discharge from coronary care unit. In a group of 339 patients with acute myocardial infarction treated in a coronary care unit, 273 left the unit while improving and were expected to leave hospital alive; 23 had a cardiac arrest or died suddenly while still in hospital-17 died immediately or after temporary resuscitation and six were resuscitated to leave hospital alive. Ventricular fibrillation was found in 13 of the 20 patients attended by the cardiac arrest team. The incidents were scattered from the 4th to the 24th day after the onset of infarction. Risk factors in these "late sudden death" patients were compared with the 250 patients who left the unit while improving and did not die or suffer cardiac arrest. The patients susceptible to late sudden death were characterized early in their hospital course by the findings of severe, predominantly anterior infarction, left ventricular failure, persistent sinus tachycardia, and frequent ventricular arrhythmias. It is suggested that such patients be chosen for prolonged observation in a second-stage coronary care unit.


Use of diazoxide in hypertension with renal failure. Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment. Rapid initial and good long-term control of hypertension was achieved in all cases without the production of clinically significant postural hypotension. The side effects of diazoxide, including its diabetogenic effect, were easily controlled. There was a highly significant improvement in renal function in most patients on long-term oral diazoxide therapy.Diazoxide may have an important place in both the short- and long-term therapy of resistant hypertension, particularly in association with renal damage.


Skin collagen and thickness in simple obesity. The effects of stretching of the skin on its collagen content and thickness have been studied in a group of subjects with chronic obesity. Despite the increase in skin surface a normal skin thickness, collagen content, and density were maintained. It is concluded that the skin stretching induced by prolonged obesity led to hypertrophy of collagen and that this had maintained both skin thickness and collagen content. It is not known whether this is due to enhanced synthesis or decreased degradation.


Factors affecting admission to a coronary care unit. Of 103 patients with suspected myocardial infarction admitted to an intensive care unit in a general hospital half were admitted within four and a half hours of the onset of symptoms. In general, patients who attended the casualty department were under intensive care sooner than patients who sought attention from their general practitioner before admission. Patients who were seen by a locum from the emergency treatment service at night or weekends were more likely to remain at home until seen the next day by their own general practitioner, compared with patients seen by their own general practitioner initially.


Survey of 3,000 unwanted pregnancies.

Survey of 3,000 unwanted pregnancies. A survey of 3,000 unwanted pregnancies disclosed two main populations differing in age, marital status, and contraceptive practice. Failure to use contraception accounted for two-thirds of the pregnancies. More than half of the patients were married women or single women in stable relationships, but many single women faced their predicament alone, without help from partner or parent.Some evidence is given of valid needs which could not be met by existing N.H.S. facilities.


Diabetic clinic in a general practice.

Diabetic clinic in a general practice.


Education and eminence in British medicine. The educational background of eminent members of the British medical profession was examined by recourse to Who's Who. Substantial differences in background were found among the various medical specialties. Members of specialties enjoying high prestige within the profession-physicians, surgeons-were more likely than other members of the sample to have been to an English school as opposed to one in Scotland, Wales, or Northern Ireland, and to a headmasters' conference school as opposed to a grammar school. Educational background was also found to relate to the aspect of the patient's body on which specialists normally worked. Specialists coming from English headmasters' conference schools were more likely than others to work on living bodies rather than dead bodies or parts of bodies, on the head rather than on the lower trunk, on male bodies rather than female bodies, and on the body's surface rather than its inside.


Immediate problems at birth.

Immediate problems at birth.


Advice in the M.D.U.'s Annual Report.

Advice in the M.D.U.'s Annual Report.


Acute renal failure.

Acute renal failure.


Epitaph for the M.C.H.C.

Epitaph for the M.C.H.C.


Better specimens from the female genital tract.


Verdict on CS.

Verdict on CS.


Epidemiology of malaria.

Epidemiology of malaria.


Drugs and the fetal heart rate.

Drugs and the fetal heart rate.


Doctor in the lab.

Doctor in the lab.


F.D.P. in glomerulonephritis.

F.D.P. in glomerulonephritis.


Treatment of myocardial infarction.

Treatment of myocardial infarction.


The gut and dermatitis herpetiformis.

The gut and dermatitis herpetiformis.


Wegener's granulomatosis.

Wegener's granulomatosis.


Halothane hepatitis.

Halothane hepatitis.


Trial of dying plaintiff's action postponed.


Winchester address: "the illiteracy of the literate".


Effect of septal stimulation on lateral hypothalamic unit activity in the rat.


Metabolic pattern of RNA in rat brain nucleus shown by gel electrophoresis.


Membrane potential changes of neuroglial cells during spreading depression in the rabbit.


Organization of the inhibitory and excitatory vestibulo-ocular reflex pathways to the third and fourth nuclei in rabbit.


Spontaneous nystagmus recorded in trochlear motoneurons following labyrinthine lesion.


GABA production in brain cortex related to activity and avoidance behaviour in eight strains of rat.


Harmaline-induced rhythmic activity of cerebellar and lower brain stem neurons.


Collicular unit responses to monochromatic stimulation in squirrel monkey.


Restoration by thiamine of the action potential in ultraviolet irradiated nerves.


A histochemical study of the distribution of the trigeminal divisions in the substantia gelatinosa of the rat.


Maximum expiratory flow-volume curves in children and adolescents.


Static recoil pressure of the lungs in children.


Pulmonary flow-volume and pressure-volume relationship during submaximal and maximal exercise in young well-trained men.


[Variations of thoraco-pulmonary resistance during the respiratory cycle studied by the oscillation method].


A device for plotting volume pressure curves of esophageal balloons in situ in a clinical set up.


Forced expiratory flow rates in isovolume pressure-flow curves.


Frequency dependence of compliance in apparently healthy smokers versus non-smokers.


Biological branching systems, with special reference to the lung airways.


Detection of unequal time constants in the lung by Xe technique.


A simplified oscillation method with electronic signal handling for the determination of airway impedance.


A comparative study of measurements in a constant volume and a constant pressure body plethysmograph.


Treatment of cancer of the breast; past, present and future.


Metastatic cells in bone marrow; study of 83 cases.


Continuous blood gas and pH measurement by the Beckman chemistry monitor model 400 (BCM-400).


Dubin-Johnson syndrome with varied manifestations. Report of two cases.


Hyperbaric oxygen effect on cognition and behavior in the aged.


Marital diagnosis for treatment planning.


Selection of therapy for marital problems.


Cardiovascular responses to acetylcholine: effects of pentobarbital and autonomic blocking agents.


Decision counseling: coping at crisis-in-transit.


The control of violence.

The control of violence.


Enforced group treatment of exhibitionists.


Multimodal group psychotherapy.

Multimodal group psychotherapy.


Self-help through Recovery, Inc.

Self-help through Recovery, Inc.


Models of delivery of mental health services in the 1970s.


The indications and techniques of partial hospitalization.


Systems approach to day hospitalization.


Homeostasis-anhomeostasis: Goliath and David.


A crisis intervention model for inpatient hospitalization.


Effects of psychoactive agents on the conditioning of the microcirculation in the rat.


Group psychotherapy for the adolescent.

Group psychotherapy for the adolescent.


Attitude therapy in a hospital setting.

Attitude therapy in a hospital setting.


The crisis center in community psychiatry: an Amsterdam experiment.


Computers in the treatment of nonspeaking autistic children.


Comprehensive therapy of unwed teen mothers.


Gestalt therapy.

Gestalt therapy.


Art therapy.

Art therapy.


Systems therapy.

Systems therapy.


Psychiatry and the deaf.

Psychiatry and the deaf.


Treatment of depression.

Treatment of depression.


Drugs in the management of anxiety.

Drugs in the management of anxiety.


Drugs in behavior therapy.

Drugs in behavior therapy.


Drug administration schedules.

Drug administration schedules.


The Veterans Administration Cooperative Study on Gastric Ulcer. 1. Goals and design.


The Veterans Administration Cooperative Study on Gastric Ulcer. 2. Healing of initial ulcers in relation to age and race.


The Veterans Administration Cooperative Study on Gastric Ulcer. 3. Site and size of the ulcer as determinants of outcome.


The Veterans Administration Cooperative Study on Gastric Ulcer. 4. The follow-up period.


The Veterans Administration Cooperative Study on Gastric Ulcer. 6. Cancer. I. Clinical aspects.


Rhe Veterans Administration Cooperative Study on Gastric Ulcer. 5. The course of recurrent ulcer.


The Veterans Administration Cooperative Study on Gastric Ulcer. 7. Coexistent duodenal ulcer.


The Veterans Administration Cooperative Study on Gastric Ulcer. 8. Multiple gastric ulcers.


The Veterans Administration Cooperative Study on Gastric Ulcer. 9. Gastroscopy.


Some neurological aspects of dementia.

Some neurological aspects of dementia.


Central disorders of the special senses in the elderly.


Deafness in the elderly.

Deafness in the elderly.


The carcinoid syndrome in an elderly woman.


Xylose aborption and serum carotene levels in the elderly.


Motivational and attitudinal content of first grade reading textbooks. Their influence on reading behavior and socialization.


Reciprocal contributions between psychoanalysis and psychoeducation.


The encopretic child and his family.

The encopretic child and his family.


The impact of the menarche. A study of two stages of organization.


Characteristics of encopretic patients and their families.


Psychiatric consultation within a community of sick children. Lessons from a children's hospital.


Juvenile delinquent and an adult prisoner. A therapeutic encounter?


The taboo of virginity. Resistances of male therapists and early adolescent girl patients in treatment.


Violence begins at home. The Parents' Center Project for the study and prevention of child abuse.


The child and the seriously disturbed parent. Patterns of adaptation to parental psychosis.


Infant-caretaker interactions.

Infant-caretaker interactions.


Leadership, participation, and self-orientation in observed and nonobserved groups.


Leadership style, hierarchical influence, and the satisfaction of subordinate role expectations: a test of Likert's influence proposition.


Job analysis method for health-related professions: a pilot study of physical therapists.


Dimensions of visual information displays.


Recognition of human faces: effects of target exposure time, target position, pose position, and type of photograph.


Relationship of initiating structure and job performance as moderated by consideration.


Characteristics of violators of formal company rules.


The contractile apparatus of the adductor muscles in Anodonta cygnea L. (Mollusca, Pelecypoda).


Shope fibroma: electron microscopic structure of associated lamellae.


Fine structure of trichocyst fibrils of the dinoflagellate Peridinum westii.


[A rare disease: apparently congenital stenosis of the perineal urethra in men. Apropos of 2 cases].


A prospectus on the prevention of aortic rupture in the Marfan syndrome with data on survivorship without treatment.


Criminal confinement and psychiatric impairment.


Studies with specific enzyme inhibitors. 13. Kinetics of nonenzymatic decarboxylation of fluorooxalacetic acid.


Inhibition of guanine metabolism of mammalian tumor cells by the carbocyclic analogue of adenosine.


Quantum mechanical study of the conformational and electronic properties of acetylcholine and its agonists muscarine and nicotine.


Acetylation of the carcinogen N-hydroxy-2-acetylaminofluorene by acetyl Coenzyme A to form a reactive ester.


The stereochemical basis of anticonvulsant drug action. 3. The structure of procyclidine hydrochloride.


Mechanism of secretion from the adrenal medulla. VI. Effect of reserpine on the dopamine  -hydroxylase and catecholamine content and on the buoyant density of adrenal storage vesicles.


Mechanism of secretion from the adrenal medulla. VII. Effect of insulin administration on the buoyant density, dopamine  -hydroxylase, and catecholamine content of adrenal storage vesicles.


An investigation into the mechanism of cytotoxicity of levorphanol.


Stability of polyribosomes isolated from rat liver after phenobarbital administration.


Study on tyrosine: 2-oxoglutarate aminotransferase activity in the liver of tumor-bearing and injured mice.


Fine structure of adrenocortical cell in Cushings's syndrome.


An experimental study of inverting intestinal anastomoses.


Vital reaction as enzymatic response to injury--with regard to distinction between antemortem and postmortem skin wounds by histochemical methods.


A study on hormone dependency of breast cancer.


Studies on the mechanism of cystine destruction and inactivation of trypsin irradiated with 280 nm light.


A geo-pathological study on malignant melanoma in Japan.


Photochemical studies on some candidate irreversible chymotrypsin inhibitors: o-azidobenzamides.


Idiopathic polyneuritis (Landry-Guillain-Barré-Strohl syndrome) and experimental allergic neuritis: a comparison.


Two proteins specific to the nervous system.


Ultrastructural and bioelectrical effects of antisera against subcellular particles from brain.


Susceptibility of mice of different strains to the mammary carcinogenic action of natural and synthetic oestrogens.


Transformation response of frozen-stored chronic lymphocytic leukemia cells: a preliminary report.


Beta-aminoisobutyric acid in urine from patients with urothelial tumours.


Mechanism of the rapid hypercalcemic effect of parathormone: inhibition of bone accretion.


Very large organ-like structures formed by syngeneic foetal alimentary tract transplanted as a whole or in parts.


Experimental apparatus to investigate transient nonolinear effects in a plasma.


Rapid modulation of microwave powered lamps for photochemistry.


Optical flats for use in x-ray spectrochemical microanalysis.


A secondary emission analog for improved auger spectroscopy with retarding potential analyzers.


A rapid scanning dual wavelength spectrophotometer.


High sensitivity microwave radiometer for low temperature plasma afterglow studies.


A mathematical model of the arc pioneer 6-7 plasma probe.


Multipass laser interferometry for plasma studies.


Total bloodlessness for extracorporeal organ repair.


Sterility, A to Z.

Sterility, A to Z.


Familial cancer susceptibility.

Familial cancer susceptibility.


The functions of an amputation clinic.

The functions of an amputation clinic.


The role of the groin dissection in the management of patients with melanoma of the lower extremity.


Contraceptive specifications: report on a workshop. It was suggested at a meeting in 1967 on the behavioral sciences and family planning programs that social scientists should be involved in the design of new contraceptives.  The Center of Population Research and the Population Council held a 2-day workshop in August 1969 to develop a more rational approach to the design of new contraceptives by working out the specifications for the variety of methods suitable  for use by different population groups.  The potential impact of improved contraception is great.  According to the 1965 National Fertility Survey, 20% of all births occurring between 1960-1965 were unwanted.  If 3/4 of these births were averted, a reduction of 15% in the number of births in 1960-1965 would have taken place.  Characteristics of contraceptives are numerous, and it is recommended that the goal should be a variety of methods that would be useful under differing circumstances.  In the development of new methods of contraception, it is acceptability, even more than effectiveness, that investigators are trying to improve.  There are a number of social and psychological factors affecting acceptability.  The kinds of contraceptives considered acceptable may differ at various stages of family growth.  Contraceptives must be dependable, acceptable, harmless, simple, and cheap.  In making observations and suggestions for research, it was noted that the development of an ideal contraceptive that is universally preferred is unlikely.  Research should aim toward an improved contraceptive system or technology--a variety of methods rather than a single best method.


Polypropylene loops: a research report.

Polypropylene loops: a research report.


Field structures in family planning.

Field structures in family planning.


Study of frozen organ preservation using canine small intestine.


Comprehensive family planning based on maternal-child health services: a feasibility study for a world program.


Hong Kong: oral contraceptive follow-up study.


Korea-Taiwan 1970: report on the national family planning programs.


Circulating catecholamines and cardiac performance following cardiac denervation.


Korea: estimating current fertility from the 1966 census.


Hypoxia and gastric mucus secretions.

Hypoxia and gastric mucus secretions.


Law and family planning.

Law and family planning.


Improved cardiovascular effects of glucagon in dogs with endotoxin shock.


Functional evaluation of the colonic interposition operation for benign esophageal stricture.


Korea: the relationship between IUD retention and check-up visits.


Family planning in Tunisia and Morocco: a summary and evaluation of the recent record. Family planning activity during 1969-1970 in Morocco and Tunisia is discussed in terms of 12 criteria (such as leadership, educational services, availability) used to evaluate the programs in the 2 countries.  Significant differences between family planning activity in the 2 countries can be seen in the nature of involvement of their governments through the open and public endorsement of family planning by Tunisia's president compared to the  reserve of Morocco's king.  Although family planning programs in both countries are organized within the Ministries of Health, the Tunisian program is conducted by a separate division, the Department of Family Planning and Maternal and Child Health, while Morocco's  program is completely integrated within existing health services, a fusion which seems to create financial problems for the Moroccan family planning efforts.  The Tunisian program, when compared to that of Morocco, is also characterized by a greater availability of contraceptives, more postpartum education and information activity, available induced-abortion and sterilization services, more  widespread use of mass media and communication techniques and greater success in program evaluation.  On a population basis, Tunisia (population of 5.2 million in 1970) has about 3 times the number of acceptors as Morocco (population of 15.4 million).  Both programs have record-keeping systems which improved considerably during 1969 and 1970, but neither program has an effective field worker network.  While Tunisia's program has demonstrated more success in meeting the criteria than Morocco's program and a slight decline has occurred in the crude birth rate in Tunisia in recent years, much of this decline can be attributed to a rising age  at marriage resulting from the government's policies of social development.  Evaluation indicated that both countries will have to increase availability of contraceptives and encourage effective use if substantial decreases in the crude birth rate are to be achieved.


The Philippines: family planning acceptors, January-June 1970.


Catholic parish priests and birth control: a comparative study of opinion in Colombia, the United States, and the Netherlands.


The contribution of cardiac sympathetics to the control of sodium excretion.


Efficiency of a soil Mycobacterium during growth on hydrocarbons and related substrates.


Biosynthesis of vitamin B 12  by Propionibacterium shermanii. V. Interrelationship between vitamin B 12  and porphyrin synthesis.


Effect of peat extract on the antibiotic activity of Penicillium chrysogenum.


On the submicroscopic structure of chromosomes.


Investigations on the life-span limitation of mussels as example of telometric growing animals.


Effect of serum from endotoxin-treated rats on isolated trypanosoma equiperdum.


Studies on cartilage formation. XIV. Uridine diphosphoglucose dehydrogenase activity of the regenerating articular cartilage.


On the cytogenetic effects of 2,4-D on pea callus in culture.


Effect of salinity, nitrate or calcium ions on the accumulation of storage substances by Chromulina pascheri.


Conditions for culturing Chromulina pascheri.


The role of lipids in enchondral ossification.


Responses of single neurons of the vestibular nuclei to lateral tilt and caloric stimulation in the intact and hemilabyrinthectomized cats.


A method for studies of the middle ear mechanics.


A comparative analysis of the audiovisual, auditive and visual perception of speech.


Mandibular ameloblastoma with pulmonary and mediastinal lymph node metastases.


Individual differences in radiosensitivity of mice correlated with their metabolic rate.


Influence of scattering foils, transmission monitors and collimating system on the absorbed dose distribution from 10 to 35 MeV electron radiation.


Microglandular hyperplasia in cervical cone biopsies taken for suspicious and positive cytology.


Fatal chlorine poisoning: report of two cases with clinicopathologic correlation.


Mechanism of obstruction in carcinoid tumors of the small intestine.


Some factors influencing platelet retention in glass bead columns including the influence of plastics.


Osmotic fragility of erythrocytes: comparison of continuous recording and multiple tube methods.


Anticoagulant monitoring of volunteers using prothrombin activity tests with abnormal control plasmas: a cooperative study.


Automated simultaneous leukocyte counting and hemoglobin determinations using the Coulter counter and the autoanalyzer.


Spurious erythrocyte indices as measured by the model S Coulter counter due to cold agglutinins.


Evaluation of a new surface adsorbent triiodothyronine (T3) uptake test.


The effects of immunosuppressive drugs and uremia on automated leukocyte counts.


International Committee for Standardization in Hematology: proposed recommendations for measurement of serum iron in human blood.


Screening test for hepatitis carriers in blood donors.


Human infection with Pasteurella pseudotuberculosis.


Evaluation of postural drainage by measurement of sputum volume and consistency.


Recovery of nerve conduction after nerve block by phenol.


Multifactorial analysis of walking by electromyography and computer.


Qualities for the community psychologist.


State vocational agency practices in the purchase of psychological services.


Anorexic humans and rats.

Anorexic humans and rats.


On Schachter on obesity.

On Schachter on obesity.


A survey of graduate education in community psychology.


Surgical treatment of intracranial aneurysms.


Current status of surgically created portasystemic shunts in the management of portal hypertension.


Cholelithiasis and cholecystitis in children.


The choroid plexus of the lateral ventricles during early human fetal life.


Effects of unilateral ovariectomy of the pregnant hamster on the remaining ovary.


Weight standards for organs from early human fetuses.


The isolated mucosa of turtle bladder.

The isolated mucosa of turtle bladder.


Postnatal development and properties of ultimobranchial follicles in the rat thyroid.


Fine structure of ultimobranchial follicles in the thyroid gland of the rat.


Effect of estrogen treatment on bone cortex of the young rat.


Neuroglial population in the spinal white matter of neonatal and early postnatal rats: an autoradiographic study of numbers of neuroglia and changes in their proliferative activity.


Cytological differentiation of the mesothelial cells of the yolk sac of the bat, Tadarida brasiliensis cynocephala.


The fine structure of bone in the nasal tubinates of young pigs.


Sequential changes in pulmonary blood flow distribution in hemorrhagic shock.


Human histopathologic response to a completely fabric-covered prosthetic heart valve.


Sudden death after phosphorus burns: experimental observations of hypocalcemia, hyperphosphatemia and electrocardiographic abnormalities following production of a standard white phosphorus burn.


Changes in the oxyhemoglobin dissociation curve and peripheral blood after acute red cell mass depletion and subsequent red cell mass restoration in baboons.


Incidence of long-term psychiatric complications in severely burned adults.


Coagulation defects associated with massive blood transfusions.


Prospective clinical evaluation of biliary drainage in hepatic trauma: an interim report.


The intestine as a source of plasminogen activator activity.


Ligation of the suprarenal inferior vena cava: application of a graphite-benzalkonium-heparin coated femoral-to-jugular vein shunt.


Hypoplastic inferior vena cava with aplasia of the right kidney and absence of the right adrenal gland.


Eck's fistula encephalopathy in germfree dogs.


Concurrence of hypernephroma and hypercalcemia.


The acetylation of insulin.

The acetylation of insulin. The acetylation of the free amino groups of insulin was studied by reaction of the hormone with N-hydroxysuccinimide acetate at pH6.9 and 8.5. The products formed were separated by chromatography on DEAE-Sephadex and were characterized by isoelectric focusing, by end-group analysis, by the incorporation of [(3)H]acetyl groups in the molecule, and by treatment with trypsin that had been treated with 1-chloro-4-phenyl-3-toluene-p-sulphonamidobutan-2-one (;tosylphenylalanyl chloromethyl ketone'). Three monosubstituted products, two disubstituted products and one trisubstituted derivative were prepared. The alpha-amino groups of the terminal residues and the in-amino group of the lysine-B29 were the sites of reaction. Acetylation of any of the free amino groups did not affect the biological activity of insulin. It was demonstrated, however, that substitution at the glycine-A1 amino group by the larger residues, acetoacetyl or thiazolidinecarbonyl, produced a decrease in biological activity. Modification of the lysine-B29 or phenylalanine-B1 amino groups with these larger reagents did not affect the biological activity. Modification of the phenylalanine-B1 amino group by any of the three substituents resulted in a large decrease in the affinity of insulin for anti-insulin antibodies raised in the guinea pig. Modification of the other two amino groups did not affect the reaction with antibody. These observations are correlated with the tertiary structure of insulin.


The purification and properties of the L-serine O-sulphate degrading system of pig liver. 1. The enzyme system from pig liver responsible for the alphabeta-elimination of l-serine O-sulphate was purified 1000-fold. 2. Isoelectric focusing produced two enzymically active fractions with isoelectric points at pH5.6 and 5.9 respectively. 3. Osmometry and gel filtration showed both enzymes to possess molecular weights of approx. 54000. 4. The separate activities exhibited similar amino acid compositions.


Aspects of glycine and serine biosynthesis during growth of Pseudomonas AM1 on C compounds. 1. Methanol or formate can replace serine or glycine as supplements for growth on succinate of the auxotrophic mutants 20S and 82G of Pseudomonas AM1, showing that the organism can synthesize glycine and serine in net fashion from C(1) units. 2. Double mutants of Pseudomonas 20S and 82G have been prepared (20ST-1 and 82GT-1) that are unable to grow on succinate+1mm-glyoxylate, succinate+2mm-methanol or methanol alone. 3. Mutants 20ST-1 and 82GT-1 lacked serine-glyoxylate aminotransferase activity, and revertants to the phenotype of 20S and 82G regained serine-glyoxylate aminotransferase activity. A total revertant of 82GT-1 to wild-type phenotype regained activities of serine hydroxymethyltransferase and serine-glyoxylate aminotransferase. 4. The activity of serine-glyoxylate aminotransferase in methanol-grown Pseudomonas AM1 is eightfold higher than in the succinate-grown organism. 5. The combined results show that in Pseudomonas AM1 serine-glyoxylate aminotransferase is necessary for growth on C(1) compounds and is involved in the conversion of methanol into glycine via glyoxylate. 6. It is suggested that the phosphorylated pathway of serine biosynthesis from phosphoglycerate replenishes the supply of alpha-amino groups necessary for the flow of glyoxylate through the main assimilatory pathway during growth on C(1) compounds.


Some properties of mitochondria isolated from the flight muscle of the periodical cicada, Magicicada septendecim. Mitochondria from the flight muscle of the periodical cicada oxidize pyruvate and d-glycerol 1-phosphate at rates comparable with those obtained with flight-muscle mitochondria from other insects. The oxidation of d-glycerol 1-phosphate is greatly stimulated by low concentrations of Ca(2+). However, oxidative phosphorylation with this substrate is optimum over only a narrow range of Ca(2+) concentration, because of the ability of these mitochondria actively to accumulate Ca(2+) present at micromolar concentrations. The oxidation of pyruvate via the complete tricarboxylic acid cycle is enhanced by high concentrations of phosphate. When both pyruvate and d-glycerol 1-phosphate are present simultaneously, there is no simple summation of the rates obtained with the substrates singly. Acetyl-l-carnitine, palmitoyl-l-carnitine, glutamate and 2-oxoglutarate are oxidized at rates similar to those obtained with mammalian mitochondria, though lower than those obtained with the two prime substrates. However, no other tricarboxylic acid-cycle intermediates added to the medium were oxidized. From these and other observations it has been concluded that these mitochondria possess a previously undescribed combination of substrate-anion permeases.


Release of intestinal surface-membrane glycoproteins associated with enzyme activity by brief digestion with papain. Rat intestinal surface-membrane glycoproteins were labelled by intraperitoneal injection of [1-(14)C]glucosamine 4h before the animals were killed. At this time, density-gradient centrifugation of disrupted brush borders indicated that glycoprotein radioactivity was distributed identically with sucrase, a plasma-membrane marker. Labelled brush borders were digested by papain for brief time-intervals known to release surface-enzyme particles without disruption of the unit membrane. Digestion for 5min released 90% of the surface sucrase, and almost one-half of the brush-border glycoprotein and label. On Sepharose 4B column chromatography most of the glycoprotein and label emerged as a single peak. This peak contained the most actively labelled glycoprotein in the brush border and was closely associated with maltase, sucrase, beta-naphthylamidase and alkaline phosphatase. The peak was partially resolved on polyacrylamide-gel electrophoresis into three bands. Each band contained a distinctive enzyme or enzyme pair, and was labelled by [1-(14)C]glucosamine. No periodic acid-Schiff-negative protein was observed in the peak material. Glycoproteins susceptible to brief digestion with papain are therefore closely linked to released surface-enzyme particles. Intestinal surface glycoproteins are heterogeneous with respect to molecular weight, electrophoretic mobility and function.


Deoxyribonucleic acid synthesis in mammalian nuclei. Incorporation of deoxyribonucleotides and chain-terminating nucleotide analogues. The properties of a nuclear preparation from rat liver and thymus are described. (1) Nearest-neighbour analysis after incorporation of (32)P-labelled nucleotide residues from dATP, dCTP, dGTP, dTTP and arabinofuranosyl analogues of CTP and ATP shows template-dependent DNA synthesis. (2) Where primer termini are limiting, incorporation of arabinofuranosyl analogues of AMP and CMP residues proceeds to a limit indicating that both of these analogues are DNA chain terminators. (3) No large differences have been found between the priming potentialities or the intrinsic DNA polymerase activities of nuclei from resting or regenerating liver and the relationship of this DNA synthesis in vitro to DNA replication or repair in vivo is briefly discussed.


The interaction of concanavalin A with blood-group-substance glycoproteins from human secretions. 1. Gastric juice, saliva and ovarian-cyst fluid were fractionated into glycoprotein components by centrifuging to equilibrium in a caesium chloride density gradient. 2. The glycoprotein fractions from the gastric juice of two group O non-secretors, two group O secretors and three group A secretors all formed insoluble complexes with concanavalin A. 3. Fractions showing maximum interaction with concanavalin A had maximum blood-group activity measured by the haemagglutination-inhibition technique. The sulphate content of the gastric glycoproteins was unrelated to the capacity to interact with concanavalin A. 4. No interaction was found between concanavalin A and the glycoprotein fractions from any of the saliva or ovarian-cyst-fluid samples tested, implying that there is a structural difference in blood-group-substance glycoproteins in gastric juice when compared with those in saliva and ovarian-cyst fluid. 5. The protein components of each of the secretions tested, gastric juice, saliva and ovarian-cyst fluid, interacted with concanavalin A.


Identification in skeletal muscle of a distinct extracellular pool of amino acids, and its role in protein synthesis. 1. The kinetics of radioactive labelling of extra- and intra-cellular amino acid pools and protein of the extensor digitorum longus muscle were studied after incubations with radioactive amino acids in vitro. 2. The results indicated that an extracellular pool could be defined, the contents of which were different from those of the incubation medium. 3. It was concluded that amino acids from the extracellular pool, as defined in this study, were incorporated directly into protein.


The isolation and identification of 3 alpha, 7 alpha-dihydroxy-5 beta-cholestan-26-oic acid from human bile.


Metabolism of unusual lipids in the rat. I. Formation of unsaturated alkyl and alk-I-enyl chains from orally administered alcohols.


Gas chromatography and mass spectrometry of the trimethylsilyl ether methyl ester derivatives of long chain hydroxy acids from Nocardia corallina.


Biosynthesis of stearic acid in rat testis.


Fatty acid oxidation in embryonic chick tissues.


Regulation of rat liver acyl-CoA synthetase activity.


Skeletal muscle lipids. I. Changes in fatty acid composition of lecithin in man during growth.


Phosphoryl-N-acetylglucosamine transfer to a lipid acceptor of liver microsomal preparations.


Repeated estimation of liver cholesterol synthesis in vivo, using the inhibitor AY-9944.


Regulation of testosterone biosynthesis in rat testes by 7 alpha-hydroxylated C 19  steroids.


The effect of testosterone on the biosynthesis of the neutral glycosphingolipids in the C57-BL mouse kidney.


The enzymic conversion of monogalactosyl monoglycerides to monogalactosyl deglycerides by spinach leaf homogenates.


-oxidation of long-chain fatty acids in cell-free extracts of arthrobacter simplex.


Tumour temperature monitoring as a possible means of selecting therapy for advanced breast cancer.


A telemetric method for monitoring foetal heart rate and intra-uterine pressure during labor.


The parable of the priests and the gnomes.


Cyclophosphamide in the treatment of multiple myeloma.


International symposium. Synthesis, structure and function of hemoglobin. Molecular biology and clinical aspects. Bad Nauheim, 22.-24. April, 1971. Results of the first two symposium days: review.


Nucleic acid content of spinal motoneurones and their satellites under orthodromic and antidromic stimulation. A cytospectrophotometric study.


Intracellular potentials of inexcitable cells in epileptogenic cortex undergoing fibrillary gliosis after a local injury.


EXperimental studies on the postnatal development of the brain. I. Cytogenesis and morphogenesis of the accessory fascia dentata following hippocampal lesions.


Differential effects of D- and L-amphetamine on behavior and on catecholamine disposition in dopamine and norepinephrine containing neurons of rat brain.


Hormonal regulation of sRNA methylase activity in regional brain areas in Peromyscus maniculatus bairdii.


Incorporation of [1-14C]linoleic acid into central nervous system of the adult cat after intracisternal administration.


A brain cell deficit in newborn guinea-pigs following prenatal hyperthermia.


An acidic protein isolated from fibrous astrocytes.


Tendon organ function.

Tendon organ function.


Effect of reserpine on sympathetic neuronal RNA.


Vasoactive drugs in shock: the great disillusion.


Hypoxemia in anesthesia and surgery.

Hypoxemia in anesthesia and surgery.


Major abdominal surgery in the elderly: a review of 172 consecutive patients.


Elemental diet in the management of the intestinal lesion produced by 5-fluorouracil in the rat.


Tone of the gastroesophageal junction: its response to abdominal compression and to swallowing.


Post-traumatic cardiocoronary fistula.

Post-traumatic cardiocoronary fistula.


Fibroma filling the renal pelvis: report of a case.


The succession of cutaneous melanophore populations in Taricha torosa.


Cellular blood constituents and serum protein fractions of the chinchilla (Chinchilla lanigera).


A photographic analysis of the air breathing behavior of the catfish, Plecostomus punctatus.


A new species from Mexico of the nearctic genus Percymoorensis, and remarks on the family haemopidae (Hirudinoidea).


Seasonal metabolic organization in the muskrat (Ondatra zibethica). I. Changes in growth, thyroid activity, brown adipose tissue, and organ weights in nature.


Photoperiodic activity changes in juvenile sockeye salmon (Oncorhynchus nerka).


Composition of adipose tissue triglycerides of the elk (Cervus canadensis), caribou (Rangifer tarandus groenlandicus), moose (Alces alces), and white-tailed deer (Odocoileus virginianus).


Metamorphosis of the perirectal malpighian tubules in the mealworm Tenebrio molitor L. (Coleoptera, Tenebrionidae). II. Ultrastructure and role of autophagic vacuoles.


A redescription of the nematode Oncholaimus vesicarius (Wieser, 1959) and observations on the pigment spots of this species and of Oncholaimus skawensis Ditlevsen, 1921.


The mass spectrometer as a gaschromatographic detector.


Gas phase analytical separation techniques applicable to problems in clinical chemistry.


Packed versus capillary columns in gaschromatography.


Evaluation of GLC and other techniques for the estimation of corticosteroids.


An evaluation of the contribution of GLC techniques for the estimation of progesterone and pregnane steroids.


Evaluation of gas-liquid chromatographic techniques for the estimation of oestrogens.


Evaluation of GLC technique for the estimation of androgens.


Steroid spectra, pattern recognition and quantitative analysis.


Variations in urinary steroid profiles after birth.


The determination of urinary 6-oxygenated cortisol in evaluating liver function.


Gas chromatographic analysis of urinary tyrosine and phenylalanine metabolites in patients with gastrointestinal disorders.


Estimation of thyroid hormones by gas-liquid chromatography.


Head space analysis.

Head space analysis.


Gas-liquid chromatography in pharmacology and toxicology. Pharmacokinetic analysis limited by the sensitivity of the analytical technique.


Analytical and pharmacokinetic studies on butyrophenones.


Deuterium isotope effects in the metabolism of N-alkylsubstituted amphetamines in man.


Determination of barbiturates in blood by GLC.


Identification of cannabivarins in hashish by a new method of combined gas chromatography-mass-spectrometry.


The relationship between personal attributes and effectiveness in teachers of the emotionally disturbed.


Two followup studies of former educable mentally retarded students from the Kansas Work-Study Project.


Encouragement of sensory motor development in the preschool blind.


Time understanding of learning disabled boys.


Diagnostic categories and obstetric complication histories in disturbed children.


A study of educators' preferences in special education programs.


Programed and traditional procedures in the auditory discrimination phase of articulatory rehabilitation.


The relationship between academic achievement and behavior dimensions.


Cognitive and affective patterns of emphasis in gifted and average Illinois classes.


Indian childhood cirrhosis: commentary.

Indian childhood cirrhosis: commentary.


Plasma zinc concentration in Indian childhood cirrhosis.


Developmental pattern in children of lower socio-economic group below 5 years of age.


Anthropometric criteria for assessing prematurity by gestation.


Physical growth in first five years.

Physical growth in first five years.


Phenotypic overlapping of autosomal trisomy syndromes and its significance.


Some observations on sweat test by Pilocarpine Iontophoresis.


Antibiotics in pertussis.

Antibiotics in pertussis.


Acrodermatitis enteropathica.

Acrodermatitis enteropathica.


A study of chronic pulmonary tuberculosis in childhood.


Porphyrin overproduction by Pseudomonas denitrificans: essentiality of betaine and stimulation by ethionine. Ethionine supplementation of a defined medium for growth of Pseudomonas denitrificans inhibited vitamin B(12) overproduction and led to the elaboration of a red pigment. The pigment was shown to be coproporphyrin III. Inhibition by ethionine of cobalamin synthesis is probably due to interference of methylation of the corrin nucleus by methionine. Accumulation of coproporphyrin III is thought to result from interference by ethionine with the activity of methionine in the coproporphyrinogenase reaction; this would inhibit formation of heme, the feedback inhibitor and corepressor of delta-aminolevulinate synthetase, thus allowing unregulated synthesis of coproporphyrinogen III and its degradation product, coproporphyrin III. Betaine, known to be required for vitamin B12 overproduction, was found to be an essential requirement for porphyrin overproduction in the presence of ethionine. Low-level production of porphyrin, which occurs in the absence of ethionine, also required betaine supplementation. Betaine is thus required for overproduction of both corrins and porphyrins in P. denitrificans.


Genetic recombination in Micromonospora. Biochemical mutants were obtained from Micromonospora chalcea, M. purpurea, and M. echinospora by using ultraviolet radiation or nitrosoguanidine. Crosses carried out between complementary nutritional mutants of the same species showed positive genetic interaction. Data are reported which indicate that the interaction between the crossed strains is due to genetic recombination. No evidence for interspecific genetic recombination was found.


Dissimilation of aromatic compounds by Alcaligenes eutrophus. The range of aromatic compounds that support the growth of Alcaligenes eutrophus has been determined, and the pathways used for the dissimilation of these substrates have been explored, largely by enzymatic analyses. The beta-ketoadipate pathway operates in the dissimilation of benzoate and p-hydroxybenzoate; the genetisate pathway, in the dissimilation of m-hydroxybenzoate; and the meta cleavage pathway, in the dissimilation of phenol and p-cresol. l-Tryptophan is oxidized via anthranilate; but the metabolic fate of anthranilate was not established. The metabolism of the three stereoisomers of muconic acid was also examined.


Regulation of the  -ketoadipate pathway in Alcaligenes eutrophus. The regulation of the synthesis of the inducible enzymes that mediate the reactions of the beta-ketoadipate pathway in Alcaligenes eutrophus has been examined by determining the inductive responses of the wild type and of mutants derived from it to metabolites of the pathway. The system of control differs in many respects from those which operate in the genera Pseudomonas and Acinetobacter.


2-keto-3-deoxygluconate, an intermediate in the fermentation of gluconate by clostridia. Five clostridial species were found to ferment gluconate via 2-keto-3-deoxygluconate which subsequently is phosphorylated to yield 2-keto-3-deoxy-6-phosphogluconate (KDPG). This compound is then cleaved by KDPG aldolase.


Action potential duration in canine Purkinje tissue: effects of preceding excitation.


The spectrum of ST segment elevation in the electrocardiograms of healthy adult men.


The Frank vectorcardiogram in left anterior hemiblock.


Vector analysis of the stimulus artefact in patients with endocardial pacemakers.


Epicardial monophasic action potential changes during blood pressure alteration in the self-breathing rabbit.


Bradycardia-dependent atrio-ventricular block. Report of two cases of A-V block elicited by premature beats.


Serum changes in drowning.

Serum changes in drowning.


Glass and paint fragments found in men's outer clothing--report of a survey.


Comparison of bullet lead specimens by nondestructive neutron activation analysis.


Comments on the determination of nationality from handwriting.


Case report. Pulmonary obliterative alveolitis due to posttraumatic fat emboli.


A large-scale study of paper by neutron activation analysis.


An approach to automated drug identification.


Differentiation of microgram quantities of acrylic and modacrylic fibers using pyrolysis gas-liquid chromatography.


Distinction between antemortem and postmortem wounds: a study of elastic fibers in human skin.


Removal of bullet between the frontal sinuses. A case report.


Incidence of bronchogenic carcinoma in Negroes. Statistical analysis of 94 cases.


Subdiaphragmatic vagotomy. A technical maneuver.


A commentary on sickle cell disease.

A commentary on sickle cell disease.


Extravesical ectopic ureters in females.


The full stomach. Review of a continuing problem for the anesthesiologist.


The black press: asset or liability to black people?


The surgical management of carcinoma of the pancreas.


Chronic calcified subdural hematoma.

Chronic calcified subdural hematoma.


Peptic ulcer disease. An 11 year study.

Peptic ulcer disease. An 11 year study.


Psychiatric screening of urban police candidates.


The neighborhood health center--the concept and the national scene.


Optimizing the window of an Anger camera for  99m Tc.


Lung abscess--an analysis of 50 cases.

Lung abscess--an analysis of 50 cases.


99m Tc-human serum albumin.

99m Tc-human serum albumin.


Use of  13 N in studies of airway closure and regional ventilation.


Phagocytic activity of the liver as a measure of hepatic circulation--a comparative study using  198 Au and  99m Tc-sulfur colloid.


The effects of coronary arterial injection of radioalbumin macroaggregates on coronary hemodynamics and myocardial function.


Correlation of pulmonary photoscan and angiogram as measures of the severity of pulmonary embolic involvement.


Production of  99m Tc on a medical cyclotron: a feasibility study.


A " 99m Tc clock" for calculating individual patient doses.


Lower normal values for  131 I thyroid uptake not related to the ingestion of white bread.


Measurement of cardiac shunting with technetium-labeled albumin aggregates.


Parathyroid scanning with  75 Se-selenomethionine and glucagon stimulation.


Scintigraphic demonstration of cerebral infarction in a "watershed" distribution.


Accumulation of  131 I-labeled albumin in a subdural hematoma demonstrated by cisternography.


Brain scan in hyperparathyroidism.

Brain scan in hyperparathyroidism.


Obstructive jaundice caused by hepatic artery aneurysm demonstration by radionuclide imaging techniques.


Inhalation lung scanning using carrier-free  113m In.


Further observation on  131 I-BSP clearance in the Dubin-Johnson syndrome.


Unidirectional versus bidirectional scanning.


Elimination of salivary gland uptake by lemon (in vertex view of brain image).


Intranasal pledgets and cerebral spinal fluid leaks.


Motives, involvements, and leadership among black college students.


Effects of frustration and magnitude of reward on selective attention, size estimation, and verbal evaluation.


Prebirth and postbirth influence on the relationship between creative ability and recorded mental illness.


Parental perception and perceived locus of control in psychopathology.


Internal-external locus of control and response to influence attempts.


Artists, architects, and engineers--three contrasting modes of visual experience and their psychological correlates.


Effects of status of attacker and intensity of attack on the intensity of counter-aggression.


Some situational determinants of the motives attributed to the person who performs a helping act.


'Replication' or, who knows what we're talking about anyway?


Rorschach productivity as related to verbal reinforcement.


Thematic drive expression and self-esteem.


The Adjective Check List applied to older institutionalized men.


Self-actualization of "paranormals".

Self-actualization of "paranormals".


Self and ideal self-concept in a drug-using subculture.


Facial expressions and gesture.

Facial expressions and gesture.


Face to face--proximity and distance.

Face to face--proximity and distance.


Overactivity in childhood.

Overactivity in childhood.


Ritualistic activity in obsessional patients.


A personal construct theory and treatment of stuttering.


Occupational cramp.

Occupational cramp.


Emotion and physiological changes in the arm.


Spasmodic torticollis.

Spasmodic torticollis.


The measurement of psychomotor activity: some clinical applications.


Aspects of the relationship between psychiatric status, sleep, nocturnal motility and nutrition.


The relationship of body weight on maximum oxygen uptake and heavy-work endurance capacity on the bicycle ergometer.


Physiological responses of a male olympic speed skater--Terry McDermott.


Physiological and psychological effects of training--a comparison of individual and gymnasium programs, with a characterization of the exercise "drop-out".


Relationship among fitness parameters, body composition, age, habitual activity and postprandial lipemia.


Peripheral blood flow response to exercise consequent to physical training.


The influence of selected anthropometric measurements on the ability of college women to perform the 35-yard dash.


Patterns of recovery following isometric and isotonic strength decrement.


Body build and dietary habits in college athletes.


The quality of officiating as an injury prevention factor in intramural touch football.


Recurrent major ventricular arrhythmias associated with thioridazine therapy.


Pulmonary geotrichosis and candidiasis.

Pulmonary geotrichosis and candidiasis.


Dandy-Walker malformation: association with syringomyelia.


Development of the pulmonary airways.

Development of the pulmonary airways.


Urinary-vaginal fistulas.

Urinary-vaginal fistulas.


Implications of hyperlipidemia associated with use of oral contraceptives.


Folate deficiency, absolute and relative.


Acute cholecystitis in children.

Acute cholecystitis in children.


Drugs, physicians, and the "medical model".


Mild hypertensive drugs.

Mild hypertensive drugs.


A-mode echoencephalography: a critical appraisal.


Fibrosarcoma of the mandible.

Fibrosarcoma of the mandible.


Profound diuresis associated with mitral regurgitation. A case report.


Acquired hemoglobin H disease.

Acquired hemoglobin H disease.


An integrated procedure for the rapid diagnosis of biliary obstruction, portal hypertension and liver disease of uncertain etiology.


Transatlantic dialogue.

Transatlantic dialogue.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 47-1971.


Crohn's disease and sarcoidosis.

Crohn's disease and sarcoidosis.


Technic of circulatory assistance.

Technic of circulatory assistance.


Defense of lymphangiography.

Defense of lymphangiography.