Alkalosis in burns in children.

Alkalosis in burns in children. The acid-base changes in 14 children with severe burns were studied for varying periods after resuscitation. A long-continued metabolic alkalosis was found, which may be due to increased adrenocortical activity.


Effect of hormonal therapy on plasma testosterone levels in prostatic carcinoma. Plasma concentrations of testosterone were estimated in normal men, in patients before treatment for prostatic cancer, and in patients who had had various forms of endocrine treatment for prostatic carcinoma. There was no decline in plasma testosterone levels with age. Patients with non-metastatic disease had levels similar to those of normal controls, but in advanced metastatic disease the levels were low. After orchidectomy the plasma testosterone level fell to that found in normal women. In every patient stilboestrol in doses as small as 1 mg three times a day suppressed plasma testosterone at first to negligible amounts, irrespective of the clinical response. Subsequently a small but significant rise in the concentration was always observed over a period of six months' oestrogen therapy. Pituitary ablation with yttrium-90 lowered the plasma testosterone concentration again to negligible amounts in patients who had been on stilboestrol. In advanced metastatic disease this was often associated with relief of pain. Preliminary studies with aminoglutethimide indicate that it can produce biochemical and clinical effects similar to those of pituitary ablation.


Use of  99 Tc m  for the routine assessment of thyroid function. (99)Tc(m)-pertechnetate is concentrated in the thyroid in the same way as iodide but it does not become organically bound. The uptake of (99)Tc(m) is a measure of the thyroid trap, and this measurement is satisfactory as a routine test in the diagnosis of thyrotoxicosis. The reproducibility of the method is such that suppression tests can be carried out when necessary even when uptake is within the normal range of 0.4-3%. (99)Tc(m) gives a low radiation dose to the thyroid and has certain other advantages over radioactive isotopes of iodine for early thyroid uptake measurements. It is particularly suitable when serial tests of thyroid function are required during treatment with an antithyroid drug.


Pyrantel embonate in treatment of hookworm infestation. The efficacy of pyrantel embonate (1,4,5,6-tetrahydro-1-methyl-2-(trans-2-(2-thienyl)-vinyl)-pyrimidine embonic acid salt; Combantrin) was evaluated in 60 cases of hookworm infestation. They were divided into six groups of 10 cases. Pyrantel embonate was administered orally, in dosage schedules (randomized) of 100, 75, 50, 20, 15, and 10 mg/kg of body weight. The stool examination for hookworm ova and coproculture were positive in each case. The predominant species was Ancylostoma duodenale (in 58 patients). After treatment with pyrantel embonate the stool examination for hookworm ova and coproculture were negative on the 10th and 15th days in each group. The blood levels of the drug were significantly higher in patients receiving 100 and 75 mg/kg body weight. In groups A and B one patient experienced nausea and vomiting on the day of administration of drug. There were no abnormal changes in liver function tests or blood urea levels in any of the groups. Hence the optimum single dose of the drug effective against hookworm infestation is 10 mg/kg body weight, and further studies are required to evaluate the minimum effective dose of pyrantel embonate.


Nephrotic syndrome: a complication of secondary syphilis.


Permanent impairment of renal function after methicillin nephropathy.


Case of Caroli's disease.

Case of Caroli's disease.


Diagnosis of primary cancer of the liver. The diagnosis of primary cancer of the liver was reviewed in 75 patients. A definitive diagnosis was made during life in 63% and in a further 20% this condition was suspected though histological confirmation was obtained only at necropsy. The most common presenting complaints were abdominal pain and weight loss and the most frequent findings hepatomegaly and ascites. Less than one-half of the patients were jaundiced and when present it was usually mild. An arterial bruit was heard over the liver in 25% of the patients. A sudden and unexplained deterioration in a patient known to have cirrhosis or haemochromatosis should raise the possibility of a primary hepatic tumour; this occurred in 24% of our patients.Alpha-fetoprotein was found in the serum of 11 out of 18 cases. The presence of a mass in the liver was frequently confirmed by liver scan, portal venography, or hepatic arteriography, but these showed no features diagnostic of a primary tumour. Liver scan also proved useful in localizing the lesion for biopsy purposes. Definitive diagnosis is dependent on the histological demonstration of the features of the tumour. This can frequently be achieved by percutaneous needle biopsy, which was positive in 38 out of 57 patients. Wedge biopsies were positive in a further nine patients.


The pre-term baby.

The pre-term baby.


Better specimens from the female genital tract.


Changes in the pattern of admissions for attempted suicide in Newcastle upon Tyne during the 1960s. Comparison of 726 admissions to Newcastle upon Tyne General Hospital for attempted suicide in the period 1 October 1966 to 30 September 1969 with a previously reported series of 276 in 1962-4 showed an overall increase in annual admissions of 77%. For both sexes under age 30 years and females over 60 years the increase was over double. Psychiatric morbidity had increased, and there was also a significant rise in the proportion of unemployed men.The relative frequency of ingestion of non-barbiturate psychotropic or hypnotic drugs and barbiturates had changed, the former now being more common than the latter as the suicidal agent. Finally, there had been a significant increase in the proportion of patients receiving subsequent psychiatric treatment.


Vasectomy.

Vasectomy.


Starch granulomatosis of the peritoneum.


Computer service for obstetric records.

Computer service for obstetric records.


Tetracycline and renal function.

Tetracycline and renal function.


Psychosis and ketamine.

Psychosis and ketamine.


An antidysrhythmic agent.

An antidysrhythmic agent.


Diagnosis of appendicitis.

Diagnosis of appendicitis.


Visual field defect in glaucoma.

Visual field defect in glaucoma.


Teratogenic effects of anticonvulsants.

Teratogenic effects of anticonvulsants.


Hepatic vein occlusion.

Hepatic vein occlusion.


Acute myocardial necrosis in paracetamol poisoning.


Air embolism during haemodialysis.

Air embolism during haemodialysis.


Elevated acetylcholinesterase activity in adult rat brain after undernutrition in early life.


The effect of spinal ischaemia on habituation of the flexor withdrawal reflex.


The role of the pyramidal tract in the production of cortically evoked movements in the brush-tailed possum(Trichosurus vulpecula).


Two types of monsynaptic inhibition of pallidal neurons produced by stimulation of the diencephalon and substantia nigra.


Studies in the sphingolipids series. XXXII. Synthesis and resolution into optical antipodes of C 20 -phytosphingosine.


Binding to mitochondrial proteins of lecithins containing known fatty acids.


Behavior of specific natural lecithins and cholesterol at the air water-interface.


Lipids of Streptomyces toyocaensis. On the structure of siolipin.


Thymidine kinase, deoxycytidine kinase and deoxycytidylate deaminase activities in phytohaemagglutinin stimulated human lymphocytes.


Stages of spreading of human diploid cells on glass surfaces.


Alterations in the Golgi apparatus of amebae in the presence of an inhibitor of protein synthesis.


Automated image analysis in autoradiography.


Ultrastructural changes associated with an invagination phenomenon in embryonic neural aggregates.


Remarkable enhancement of transplantable tumor growth by antiserum prepared from the heavier lymphocyte fraction.


Induction of polyploidy by concentrated thymidine.


Isolation and long-term cell culture of epithelial-like cells from rat liver.


Requirements for spontaneous contractility in isolated adult mammalian heart muscle cells.


Number of ribosomal RNA cistrons in the marine mud snail Ilyanassa obsoleta.


Ultrastructure of fibroin in the silk gland of larval Bombyx mori.


Heterochromatin in cells derived from Aedes albopictus (Skuse) mosquito tissue culture.


Further measurements of DNA synthesis and enzyme potential during cell cycle of fission yeast Schizosaccharomyces pombe.


DNA polymerase and DNA nuclease activities in S-competent and S-incompetent nuclei from Tradescantia pollen grains.


Isolation and separation of S-competent and S-incompetent nuclei from Tradescantia pollen grains.


Radiation-initiated DNA synthesis in spermatogenic cells of the mouse.


"Unscheduled" DNA synthesis in human germ cells following UV irradiation.


Synthesis of soluble protein during the cell cycle of the fission yeast Schizosaccharomyces pombe.


Asynchronous condensation of chromosomes from early prophase to late prophase as revealed by electron microscopic autoradiography.


Differential effect of actinomycin D on amino acid incorporation by microsomal components of the housefly Musca domestica.


Electron microscopy of urinary glycoprotein and its relation to cystic fibrosis.


Determination of nitrogen in organic materials by prompt (n, ) technique.


Cerebral hemispheric blood flow: clinical correlation.


Sterilization of the spotted bollworm of cotton by gamma radiation.


Liquid scintillation counting of  45 Ca in soft tissues.


New spectral species of L-lysine monooxygenase, a flavoprotein.


Conformational differences in the active sites of muscle and erythrocyte pyruvate kinase.


Developmental changes occurring in isolated intact etioplasts.


The neuropil of the periglomerular region of the olfactory bulb.


Particles within membranes: a freeze-etch view.


Ultrastructure of the fungal nucleus. II. The kinetochore equivalent (KCE).


Effects of adrenalectomy on daily rhythms in oxygen consumption of tissues in the growing rat.


The glucose, insulin and glutamine requirements of suspension cultures of HeLa cells in a defined culture medium.


Hormonal mechanism of growth and development in Spodoptera littoralis Boisduval (Noctuidae).


Effect of antidiuretic hormone on bile formation in sheep.


RNA and protein content in different hypothalamic areas: influence of castration.


Isolation and identification of 3 -hydroxy-5 -androst-16-ene and 5 -androst-16-en-3-one from procine adipose tissue.


The amino acid-fermenting clostridia.

The amino acid-fermenting clostridia.


Nutritional requirements of Streptococcus salivarius.


Diurnal variation of the serum cortisol level of geriatric subjects.


Influence of age and sex on plasma and red-cell zinc concentrations.


Effect of age and H-1 virus on healing fractures in hamsters.


Cushing's syndrome: a study of 6 cases.

Cushing's syndrome: a study of 6 cases.


Hepatic changes in diabetes mellitus.

Hepatic changes in diabetes mellitus.


Intra-uterine foetal death.

Intra-uterine foetal death.


Cushing's syndrome--dominance or disobedience?


Various systems of surgical practice in India.


Dietary influence on the calcium content of tissues.


The problem of leg length discrepancy.

The problem of leg length discrepancy.


Tissue lipids in leprosy.

Tissue lipids in leprosy.


Malnutrition and the medical profession.


World Health Day.

World Health Day.


Effect of exogenous steroids on sterol synthesis in L-cell mouse fibroblasts. A number of steroids have been tested in an L-cell tissue culture system to determine their effects on cellular sterol biosynthesis and cellular growth. Cholesterol, desmosterol, lathosterol, 7-dehydrocholesterol, and cholestanone reduce de novo synthesis and produce only limited toxicity at high concentrations of exogenous sterol. Considerable cellular toxicity is observed when cells are grown in the presence of coprostanol and Delta(4)-cholestenone. No marked effect on either cell growth or sterol biosynthesis is produced by cholestanol, beta-sitosterol, stigmasterol, campesterol, ergosterol, cholesteryl oleate, or cholestane.


Comparison of the metabolism of cholesterol, cholestanol, and  -sitosterol in L-cell mouse fibroblasts. The following data have been obtained from comparative studies on the metabolism of cholesterol, cholestanol, and beta-sitosterol by L-cell mouse fibroblasts. (1) When the sterols are added to the growth medium under similar conditions, cellular incorporation of cholesterol > cholestanol > beta-sitosterol; (2) only limited cellular esterification of these compounds occurs; (3) no metabolic products arising from the sterols could be detected; (4) influx of all sterols is dependent upon the concentration; and (5) exogenous cholesterol reduces mevalonate incorporation into cellular sterol to a lesser extent than acetate or glucose. The metabolism of these sterols is discussed in relation to their ability to influence de novo sterol biosynthesis.


Relation of lipid peroxidation to loss of cations trapped in liposomes. Lipid peroxidation and alterations in cation loss have been induced in liposomes by ferrous ion, ascorbic acid, reduced and oxidized glutathione, and gamma radiation. Modifications of these effects by tocopherol and 2,6-di-tert-butyl-4-methylphenol (BHT) were studied when these antioxidants were either incorporated in the membrane or were added to already formed liposomes prior to the addition of the chemical agent or to irradiation. Lipid peroxidation, as indicated by the thiobarbituric acid test for malonic dialdehyde, did not correlate with alterations in cation loss. The largest amounts of lipid peroxidation induced by ascorbic acid and glutathione were associated with decreased cation loss. Inhibition of Fe(2+)- and radiation-induced lipid peroxidation by antioxidants did not inhibit the associated increase in cation loss. Tocopherol was a more effective antioxidant than BHT when it was incorporated in the membrane, whereas BHT was more effective when it was added to the liposomes after formation.


Bile acid sulfates. I. Synthesis of lithocholic acid sulfates and their identification in human bile. Sulfate esters of lithocholic, glycolithocholic, and taurolithocholic acids were synthesized using sulfur trioxide in pyridine; they were purified by crystallization from methanol or ethanol as the diammonium salts, and their chemical compositions, infared spectra, and chromatographic behavior were determined. Strong alkaline hydrolysis of these sulfates, as commonly performed during quantitative and qualitative analyses of conjugated bile salts, was found to result in a number of degradation products, presumably through disruption of the C-O bond of the hydroxyl group and conversion of the original steroid to isolithocholate and other (possibly olefinic) compounds. After oral administration of lithocholate-(14)C to three patients with cholelithiasis, radioactive metabolites having the chromatographic properties of sulfated lithocholates were isolated from bile and, confirming a preliminary report (1), were identified as sulfated glycolithocholate and taurolithocholate by their characteristic chromatographic mobilities during a series of specific hydrolytic procedures and by crystallizing them to constant specific activities with the synthetic sulfates. The fraction of endogenous lithocholate present in bile as the sulfate was calculated for two patients by isotope dilution and was shown to be 41% and 75% of the total. Sulfation can be expected to affect the physiological and pharmacological properties of lithocholates and may, therefore, influence the toxic properties of these compounds.


Bile acid sulfates. II. Formation, metabolism, and excretion of lithocholic acid sulfates in the rat. Sulfate esterification has been shown previously to be a prominent feature of lithocholate metabolism in man. These studies were undertaken to ascertain whether this metabolic pathway is also present in rats, and to investigate the physiological significance of bile acid sulfate formation. Lithocholic acid-24-(14)C was administered to bile fistula rats, and sulfated metabolites were identified in bile by chromatographic and appropriate degradative procedures. They constituted only a small fraction (2-9%) of the total metabolites but a more significant fraction (about 20%) of the secreted monohydroxy bile acids, most of the lithocholate having been hydroxylated by the rat liver. When sulfated glycolithocholate was administered orally, it was absorbed from the intestine without loss of the sulfate, presumably by active transport, and secreted intact into the bile. In comparison with non-sulfated lithocholate, an unusually large fraction (24%) of the sulfated bile acid was excreted in the urine, and fecal excretion took place more rapidly. Both the amino acid and sulfate moieties were extensively removed prior to excretion in the feces. Hydroxylation of bile acid sulfates or sulfation of polyhydroxylated bile acids did not occur to any great extent, if at all.


Metabolism of deoxycholic acid in bile fistula patients. Although it has been assumed that the secondary bile acid deoxycholic acid is not rehydroxylated by the human liver, little direct evidence is available to support this assumption. To investigate the metabolism of deoxycholic acid in man, deoxycholic acid-(14)C was given intravenously to two patients with complete external bile fistulas. After hydrolysis of the bile salts and chromatographic separation of bile acids, more than 94% of the radioactivity was found in deoxycholic acid and the remainder was scattered in several small unidentified peaks, none of which was cholic acid. Approximately 85% of deoxycholate was excreted as glycine conjugates and 13% as taurine conjugates in this experiment. No detectable sulfate esters were found. These results indicate that the metabolism of deoxycholic acid in man involves only the reconjugation with glycine and taurine without rehydroxylation to cholic acid or sulfation.


Cellularity of adipose depots in the genetically obese Zucker rat. Cell size and number of three adipose depots, epididymal, retroperitoneal, and subcutaneous, were determined during growth of the obese Zucker rat ("fatty") and nonobese Zucker control. Cellularity of these depots in the adult "fatty" was compared with that in nonobese controls and in nonobese Zucker rats made obese by ventromedial hypothalamic lesions. Epididymal and retroperitoneal depots in the nonobese rat grew by cell enlargement and increase in cell number until the 14th wk, when number became fixed; further increase in depot size occurred by cell enlargement. The subcutaneous depot added cells until the 26th wk. In the Zucker "fatty," cell number increased until the 26th wk in all depots, accompanied by extreme cell enlargement. The enlarged adipose depots of the adult Zucker "fatty," when compared with the nonobese control, are the result of both hypertrophy and hyperplasia. Depot enlargement in the lesioned animal is the result of hypertrophy. "Fatties" have more cells in adipose depots than do lesioned rats. Genetic obesity in the Zucker rat is clearly different from the obesity produced by hypothalamic lesioning.


Lipogenesis from glucose-2- 14 C and acetate-1- 14 C in aorta. Lipogenesis was measured with glucose-2-(14)C and acetate-1-(14)C in the everted aortas of normal and atherosclerotic rabbits. More glucose-2-(14)C than acetate-1-(14)C was incorporated into lipids in both the normal and the atherosclerotic aorta. Radiocarbon from glucose-2-(14)C appeared mainly in triglycerides and phospholipids with a small amount in cholesteryl esters. Incorporation increased almost threefold with atherosclerosis, most of the radioactivity being in the glycerol moiety; radioactivity was predominantly in carbon 2 of glycerol. About 70% of the acetate-1-(14)C incorporated into phospholipids and triglycerides was in the fatty acids, and the remainder was in glyceride-glycerol; 98% of the radioactivity in cholesteryl esters was in the fatty acid moiety. Incorporation into cholesteryl esters was increased most during the development of atherosclerosis. Fatty acid synthesis was similar from both acetate-1-(14)C and the 2 carbon unit derived from glucose-2-(14)C, viz., predominantly de novo synthesis of fatty acids with 14 and 16 carbon atoms, and elongation for those of 18 carbons and longer.


Glucose: a possible intermediate in the oxidation of the side chain of cholesterol in resting and stimulated rats. The effect of repeated muscular contraction on the rate of oxidation of the side chain of cholesterol was studied in anesthetized rats. The animals received an intravenous pulse-label injection of either cholesterol-26-(14)C, incorporated into rat plasma lipoproteins, or bicarbonate-(14)C. In half the animals of each group, the hind legs were repeatedly stimulated by electrical impulses. A multicompartmental analysis was attempted, based on the disappearance curve of plasma free cholesterol-(14)C and on the excretion rate of expired (14)CO(2), as well as on previously reported rates of bile acid and adrenal steroid secretion. The rate of expired (14)CO(2) originating from cholesterol-26-(14)C was much less than that predicted by the digital computer analysis; cholesterol degradation could not be evaluated since the data were incompatible with a model that assumes direct oxidation of the side chain to CO(2). A revised model was postulated in which an important fraction of the side chain of cholesterol would be converted to CO(2) only after previous conversion to glucose. Direct measurement of plasma glucose-(14)C after the injection of cholesterol-26-(14)C supported this hypothesis.


A convenient procedure for the synthesis of ceramides. A procedure for the preparation of ceramides by direct coupling of long-chain bases and fatty acids in the presence of a mixed carbodiimide is described. This method has been used to prepare ceramides containing sphing-4-enine or sphinganine and various saturated and unsaturated fatty acids as well as saturated 2-hydroxy acids. Ceramides containing 4-hydroxy sphinganine and saturated nonhydroxy acids have also been prepared. The yields were 60-75%. The characterization of these compounds by gas-liquid chromatography-mass spectrometry as trimethylsilyl derivatives has been previously reported. Some of the ceramides are further characterized in this report by infrared spectroscopy and one compound, in addition, by elementary analysis. Use of racemic constituents for 2-hydroxy acid ceramide syntheses leads to the formation of diastereoisomers which separate by thin-layer chromatography. These were characterized by gas-liquid chromatography-mass spectrometry as the trimethylsilyl derivatives and by infrared spectroscopy. Their configurations were established by syntheses with optically active constituents.


Formation of 1-O-2'-hydroxyalkyl glycerophosphatides from 1,2-heptadecanediol in myelinating brain. 1,2-Heptadecanediol-2-(14)C was administered intracerebrally to 18-day-old rats, and its incorporation, after 8 hr, into the individual aliphatic moieties of the ethanolamine glycerophosphatides was determined. Much of the radioactivity was found in a lipid fraction identified as 1-O-2'-hydroxyheptadecyl glycerol. Evidence is presented that a major portion of the precursor was incorporated into 1-O-2'-hydroxyheptadecyl-2-acyl ethanolamine phosphatides. Some of the diol administered was degraded to palmitic acid. The palmitic acid-1-(14)C derived from 1,2-heptadecanediol-2-(14)C apparently served as precursor for stearic and oleic acids, which were found as acyl groups, and for the biosynthesis of the corresponding O-alkyl and O-alk-1-enyl glycerols. The data presented prove that biological dehydration of 1-O-2'-hydroxyalkyl glycerophosphatides to the corresponding plasmalogens does not occur in myelinating brain.


A note on the stability of conjugated diene absorption of rat liver microsomal lipids after carbon tetrachloride poisoning. Liver microsomal lipid peroxidation has been observed in fatal human CCl(4) poisoning, in rats with fatty livers induced by CCl(4) or by yellow phosphorus, and in mice poisoned with 1,1,2,2-tetrachloroethane. These observations suggest the possibility that other instances of toxic liver injury may involve lipid peroxidation. Cases of acute, fatal, toxic liver injury (e.g., from halothane anesthesia) are not likely to occur at or near laboratories equipped to determine whether any lipid peroxidation might have taken place. The data presented indicate that rat livers may be stored frozen for at least 7 days with no demonstrable diminution in CCl(4)-induced conjugated diene absorption of liver microsomal lipids.


A method for the determination of lipoprotein lipase in postheparin plasma and body tissues utilizing a triolein-coated Celite substrate. A simple and specific method for assaying lipoprotein lipase activity is described. Postheparin plasma, heart homogenates, or extracts of acetone powder of adipose tissue were incubated with a triolein-coated Celite substrate, and enzyme activity was determined from the rate of free fatty acid (FFA) release in the incubation system. FFA release was linear for 30 min, and was proportional to protein concentration in the incubation system. FFA release was decreased by addition of deoxycholate or Triton X-100. Increasing the concentration of heparin in the incubation system caused a gradual decrease in FFA release by postheparin plasma and increases in activity of heart homogenates and adipose tissue lipoprotein lipase. The Celite substrate was found to be satisfactory for assaying pancreatic lipase activity as well.


On methylation of unsaturated acids using boron trihalide-methanol reagents. Methanolysis of unsaturated fatty acids and triglycerides was carried out with boron trihalide-methanol reagents of various ages. Boron trichloride-methanol produced esters apparently free from contaminants; boron trifluoride caused some loss of highly unsaturated esters after 90 min at 100 or 120 degrees C in Teflon-lined screw-cap vials and at 120 degrees C in ampoules. The losses were more marked when the reactions were carried out in vinyl-lined screw-cap vials. Noticeable losses did not occur with any of the vessel types when BCl(3)-CH(3)OH was the methylating agent. Long-term studies at 80 degrees C further demonstrated that BCl(3)-CH(3)OH caused less loss of unsaturated acid than did BF(3)-CH(3)OH.


Determination of the specific radioactivity of fatty acids separated as their methyl esters by gas-liquid chromatography. Free or combined (3)H-labeled fatty acids are converted to their methyl-(14)C esters or, if labeled with (14)C, to their methyl-(3)H esters. For a given specific radioactivity of the methyl group, the nuclide ratio in the esters separated by GLC is a direct measure of the specific radioactivity of the fatty acids, and quantitative collection is unnecessary. Methods of methylation with minimum quantities of labeled methanol, and of deriving nuclide ratios from channel ratios in a scintillation spectrometer, are given.


Determination of theophylline and caffeine from biological materials.


Erythrocyte reduced glutathione level and its stability in hemoglobinopathies and iron deficiency anemia.


House mites and allergic bronchial asthma.


Ossifying subcutaneous neurilemoma. Evidence that neurilemoma is of mesencymal origin.


Torsion of the stomach. Report of two cases.


Isolation of Phialophora gougerotii from a Thai patient.


Oral glucose tolerance in the early puerperium.


Failed induction of labour.

Failed induction of labour.


Neonatal acidaemia related to procrastination at Caesarean section.


Acquired genito-urinary fistulae in the Sudan.


Antibodies to type 1 and type 2 herpes virus in women with abnormal cervical cytology.


Recurrent abdominal pregnancy.

Recurrent abdominal pregnancy.


Configuration of the fetal electrocardiogram in relation to fetal acid-base balance and plasma electrolytes.


A general procedure for the preparation of deuterated and tritiated amino acids by incorporation of solvent isotope during synthesis.


A quantitative study of the glycogen content of human fetal skin in the first trimester.


Amino acids and peptides. XXVII. Synthesis of a decapeptide sequence (A 1 -A 10 ) of rubredoxin.


Interpretative aspects on the acid-base composition and its variation in fetal scalp blood and maternal blood during labour.


Coagulation, fibrinolysis and platelet function in pre-eclampsia, essential hypertension and placental insufficiency.


Participation of the anterior hypothalamus in the baroreceptor reflex. 1. On the basis of discrete electrical stimulation in the pre-optic region and anterior hypothalamus of anaesthetized cats, a depressor area has been defined, stimulation of which elicits a fall of arterial blood pressure of 30-50 mm Hg and a bradycardia of some 25%, caused by inhibition of sympathetic vasomotor tone and by vagal activation respectively. These are accompanied by a reduction in rate and depth of respiration.2. The depressor area, from which this pattern of response is elicited, lies ventral and caudal to the anterior commissure, and extends caudally in the dorsal hypothalamus, dorsal to the fornix.3. The pattern of response elicited from identified points in the depressor area was shown to be indistinguishable from that to baroreceptor afferent stimulation.4. A lesion destroying the hypothalamic depressor area bilaterally reduced the response to baroreceptor afferent stimulation. Lesions in the medullary depressor area which spared a large part of the nucleus of the tractus solitarius also reduced, but did not abolish, the baroreceptor reflex response. The two lesions combined abolished the reflex.5. It is concluded that the whole brain-stem depressor area, from the hypothalamus through the mid-brain to the medulla, constitutes a functional unit which integrates the response to baroreceptor afferent stimulation.


Enhancement of the post-occlusive oscillation in the splenic circulation by adenosine. 1. The blood flow to the splenic artery of dogs anaesthetized with sodium pentobarbitone was measured under constant pressure perfusion with the animal's own blood led from the femoral artery.2. Immediately after release of occlusion there was a rapid increase of inflow rate above the pre-occlusion level which then oscillated up and down. In a majority of cases such oscillatory responses continued for a while but progressively diminished during a period of about 6 min.3. This post-occlusive oscillatory response was not modified by either neural or autonomic receptor blocking agents such as tetrodotoxin, guanethidine, phentolamine, propranolol, atropine and methysergide.4. In the cases with a relatively short-lasting response, the selective administration of adenosine into the splenic artery caused a distinct enhancement of the oscillation.5. These results suggest that adenosine may play an important role in the post-occlusive oscillatory response of the splenic circulation.


The permeation of several materials into the fluids of the rabbit's brain. 1. (24)Na, (36)Cl and (35)S thiourea were infused I.V. in rabbits according to schedules designed to yield approximately level activity in plasma for periods up to 5 hr. Cerebrospinal fluid was sampled before ending the experiment by decapitation and the radioactivities in cerebrospinal fluid and in homogenized brain were compared in each case to a time weighted mean value for plasma.2. The results are considered in terms of a simplified model which specifically acknowledges the continuity of the extracellular and cerebrospinal fluids and thus the coupling between processes which occur at the interfaces bordering those fluids.3. From the rate constants for exchange across the blood-brain interface that were necessary for simulation of the observed behaviours, permeability coefficients for that interface were estimated for the materials studied and, from experiments of others, for (42)K.


Distribution of magnesium in the arterial wall. 1. The Mg, Ca, Na and K content were determined in the rat tail artery in vitro under various experimental conditions.2. The arterial Mg could be varied selectively at a constant [Mg](o) by altering the content of intracellular compounds capable of forming complexes with Mg(2+) such as nucleoside-5'-triphosphates or citrate.3. The release of tissue Mg during incubation in Mg-free solutions was found to consist of a fast and a slow component. The size of the fast component was dependent on the original [Mg](o). The size of the slow component was dependent on the content of intracellular compounds forming complexes with Mg(2+). The rate of efflux of the slow component could be increased by increasing [Mg(2+)](i), by removing external Ca, or by making the artery metabolically inactive.4. The results seem to indicate that [Mg(2+)](i) in metabolically active vascular smooth muscle cells is maintained at a level of ca. 10(-4)M.


Reflex effects on the heart of stimulating left atrial receptors. 1. Stimulation of left atrial receptors, by distension of the pulmonary vein/left atrial junctions, is known to cause a reflex increase in heart rate; the efferent pathway is known to be solely in the sympathetic nerves.2. In expectation of a concomitant positive inotropic response the effect of stimulating the left atrial receptors on the inotropic state of the left ventricle was studied, using as a known sensitive index of inotropic changes the maximal rate of rise of pressure in the left ventricle (dP/dt max).3. Stimulation of left atrial receptors resulted in an increase in heart rate but there were no significant concomitant changes in dP/dt max.4. It is concluded that activity in this discrete efferent pathway does not include an inotropic effect on the left ventricle and therefore the reflex involves only those sympathetic nerves which innervate the sinu-atrial node.5. The possible function of atrial receptors in the regulation of heart volumes is discussed.


Depression of the reflex tachycardia from the left atrial receptors by acidaemia. 1. The effects are described of an acidaemia, produced either by the inhalation of carbon dioxide or by an intravenous infusion of hydrochloric acid, on the reflex increase in heart rate which results from stimulation of the left atrial receptors in the anaesthetized dog.2. The results show that during acidaemia the reflex increase in heart rate from stimulation of the left atrial receptors is reduced. The extent of the reduction is related to the degree of the acidaemia.3. It is suggested that it is necessary to monitor and correct changes in the pH of arterial blood in experiments which involve reflex changes in heart rate, especially if the efferent pathway involves the sympathetic nerves.4. It is also suggested that the occurrence of such an acidaemia in anaesthetized surgically traumatized animals may be a factor contributing to the variability in results from investigations involving reflex changes in heart rate in response to stimulation of the left side of the heart.


Neuronal pathway of the recurrent facilitation of motoneurones. 1. The recurrent facilitation of motoneurones is a disinhibition, i.e. a release of the motoneurones from a sustained hyperpolarization evoked by tonically active inhibitory interneurones. Only two groups of interneurones are known to receive recurrent inhibition from motor axon collaterals via Renshaw cells; the interneurones mediating the reciprocal Ia inhibition and the Renshaw cells themselves. The properties of these two groups of neurones were studied to determine if they could produce the tonic inhibition of motoneurones removed during recurrent facilitation.2. It was found that the tonic firing of Ia inhibitory interneurones is sensitive to anaesthetics to the same degree as is recurrent facilitation. The range of frequencies of tonic discharges of Renshaw cells appeared to be similarly low in unanaesthetized and anaesthetized preparations although in individual cells the discharge rates were decreased by anaesthesia.3. The recurrent inhibition of Ia interneurones inhibiting a given group of motoneurones and the recurrent facilitation of the same group of motoneurones were, as a rule, evoked from the same nerves, although in some cats the origin of the recurrent facilitation was somewhat wider. In contrast no evidence could be found that the Renshaw cells which inhibit a functional group of motoneurones are inhibited by volleys in the nerves from which recurrent facilitation is regularly evoked.4. It was concluded that the recurrent facilitation is caused mainly by inhibition of the tonic activity of Ia inhibitory interneurones and that it is thus a manifestation of the recurrent control of Ia reciprocal inhibition of motoneurones.


Long-term observations on the Blalock-Taussig operation. II. Second operations, frequency and results.


A new approach for determining the volume of cerebral cellular fluid and demonstration of its communication with C.S.F. 1. A new technique is presented for determining the volume of extracellular space in bowfin (Amia calva) brain during in vitro incubation. It consists of solving simultaneous equations which are applied to determine the volume of extracellular space as well as intracellular marker concentration. This technique allows for a better insight into the redistribution of marker between incubation medium and extracellular space as well as between extracellular and intracellular space.2. Na(+), K(+) and Cl(-) equilibrated within 10-15 min between incubation medium and extracellular space. There was no evidence of a homoeostatic mechanism controlling the concentration of these ions in the extracellular fluid, which appeared to be in equilibrium with cerebrospinal fluid. The extracellular spaces of these ions were identical: Na(+), 23.4; K(+), 23.3 and Cl(-), 23.2%.3. Sorbitol equilibrated with the extracellular fluid within 45 min and indicated an extracellular space of 22.6%, nearly identical with that for electrolytes.4. Vastly different ;spaces' were obtained for [(3)H]methoxy inulin, which equilibrated within 45 min with a 13% space and [(14)C]carboxyl inulin, which showed a 46% space value for only 30 min. The difference may be explained by marker decomposition. The 9% difference between the [(3)H]methoxy inulin and sorbitol spaces may be explained by a ;packing' factor attributable to molecular size.


Long-time observations on the Blalock-Taussig operation. 3. Common complications.


The relative value of the medical staff versus addicts in the rehabilitation of the drug users in a drug abuse program.


The effect of acetylsalicylic acid on the metabolism and transformability of human lymphocytes in vitro.


Inefficient energy utilization in chronic cardiac failure. Studies on the isolated, normal and chronically failing human ventricular myocardium.


Automated multiphasic health testing and services. Total systems analysis and design.


Automated management of routine medical records in general practice.


Assessment of questions and questionaries.


Statisical logic in the monitoring of reactions to therapeutic drugs.


Central and peripheral neural pathways necessary for pineal function in the adult female rat.


Effects of dexamethasone and pentobarbital on plasma growth hormone levels in rats.


Influence of the pineal gland on the neurosecretory activity of the supraoptic hypothalamic nucleus in the male rat.


Septal lesions and resting adrenal function. A possible explanation of conflicting findings.


Wavelength regulation in visual pigment chromophore. Large induced bathochromic shifts in retinol and related polyenes.


Luminescence spectra and photocycloaddition of the excited coumarins to DNA bases.


The photochemistry of  14 C-5-bromo-2'-deoxyuridylyl-(3' to 5')-thymidine. Determination of quantum yields as a function of pH.


Susceptibility of Biomphalaria amazonica to infection with two strains of Schistosoma mansoni.


Treatment of tetanus at hospital das clínicas School of Medicine, University of São Paulo.


The effect of oestradiol-17  on the meatbolism of chondroitin sulphate B. IV. The effect of oestradiol-17  on the activity of uridine diphosphate-D-glucuronic acid-5-epimerase in rat skin.


The effect of oestradiol-17  on the metabolism of chondroitin sulphate B. V. The effect of oestradiol-17  on the protein content and composition of the uridine diphosphate-D-glucuronic acid-5-epimerase-containing protein fraction of rat skin.


Rate of blood flow from the internal mammary artery.


Emergency coronary artery bypass.

Emergency coronary artery bypass.


Infection by air-borne bacteria with cardiopulmonary bypass.


Autogenous tissue cardiac valves.

Autogenous tissue cardiac valves.


Radionuclide quantitation of lung function in patients with pulmonary disorders.


Arteriovenous fistula in the portal circulation.


Absence of reflex pulmonary hypertension and systemic hypotension following blood clot pulmonary embolism.


The role of the Linton flap procedure in the management of stasis dermatitis and ulceration in the lower limb.


Present status of the inferior vena cava umbrella filter.


Inhibition of experimental arterial thrombosis in dogs with platelet-deaggregating agents.


Surgical correction of carotid artery obstruction in children.


Evaluation of an impedance flowmeter in arterial surgery.


Late occlusion of aortofemoral bypass grafts: influence of cigarette smoking.


Aortoiliofemoral atherosclerotic occlusive disease: comparative results of endarterectomy and Dacron bypass grafts.


Phasic and tonic response in the cat optic nerve fibers--stimulus-response relations.


Urocanic aciduria: a defect in the urocanase activity in the liver of a mentally retarded.


Effects of maltose on insulin secretion in perfused rat pancreas.


Hypokalemia in experimental renovascular hypertension.


Spinal root pathway of the adrenal medullary secretory nerve fibers in the dog.


Comparative studies on the adrenal medullary and cortical response to histamine.


Metabolism of phosphatidylcholine in brain and liver of developing rats.


Stochastic properties of spontaneous impulse activity in central single neurons.


Programmed instruction at the SWRMCD: its impact.


Medicines, medical care, manpower and mankind.


Transposition of the great arteries with posterior aorta, anterior pulmonary artery, subpulmonary conus and fibrous continuity between aortic and atrioventricular valves.


Planning a hospital pharmacy facility.

Planning a hospital pharmacy facility.


An innovative design in hospital pharmacy facilities.


Layout and design for mechanized centralized unit dose dispensing.


A national survey of planning for hospital pharmacy facilities.


A clinically oriented hospital pharmacy intern-resident program.


Disinfection of medical and surgical materials.


Drug Products Information File simplifies computer applications.


Coelomic mesothelium-like cells in the ovarian stroma of patients with the polycystic ovary syndrome (Stein-Leventhal syndrome).


Gestational diabetogenesis: quantitative analyses of glucose-insulin interrelationship between normal pregnancy and pregnancy with gestational diabetes.


Amniotic fluid progestins and estrogens in relation to length of gestation.


"The pill".

"The pill". Sartwell responds to Kistner's earlier criticisms of a paper of his dealing with the risks of venous thrombosis in the use of oral contraceptives and points out that many of the criticisms had been made previously by Goldzieher in testimony  before the Subcommittee on Monopoly on the Select Committee on Small Business, Present Status of Competition in the Pharmaceutical Industry, Part 15, Oral Contraceptives.  Kistner and Goldzieher respond to Sartwell.


The elephant's ears can be misleading.

The elephant's ears can be misleading.


Morphine "anesthesia"--a perspective.

Morphine "anesthesia"--a perspective.


Metabolism of 7- 3 H-pregnenolone in normal human placenta maintained in organ culture.


The absence of an effect of halothane on blood hemoglobin O 2  equilibrium in vitro.


The measurement of gas trapped in the lungs at functional residual capacity and the effects of posture.


Effects of general anesthesia, muscle paralysis, and mechanical ventilation on pulmonary nitrogen clearance.


The effect of nitrous oxide on alveolar carbon dioxide tension: a second-gas effect.


Is protamine a clinically important anticoagulant? A negative answer.


Quantitative aspects of the chronotropic and neuromuscular effects of gallamine in anesthetized man.


A technique for measuring reactivity of the glottis.


Sensitivity to nondepolarizing muscle relaxants in amyotrophic lateral sclerosis: report of two cases.


Hematoma following epidural anesthesia: report of a case.


Accidental intra-arterial injection of promethazine HCl during general anesthesia: report of a case.


Pulmonary embolism following spinal anesthesia: report of a case.


Clinical implications of halothane contamination of the anesthetic circle.


Bilateral cervical and thoracic epidural blockade complicating interscalene brachial plexus block: report of two cases.


Hyperosmolar hyperglycemic non-ketotic coma following general anesthesia: report of a case.


Thiopental anaphylaxis: a case and a method for diagnosis.


Design of a wide-angle ophthalmoscope.

Design of a wide-angle ophthalmoscope.


Dietary alterations in polyunsaturated fatty acids in guinea-pig brain, liver and muscle.


Chemical composition of an oestrogen-induced calcium-binding glycolipophosphoprotein in Xenopus laevis. 1. Oestrogen treatment has previously been shown to induce the formation of large amounts of a serum protein, vitellogenin (xenoprotein), in Xenopus laevis. Vitellogenin was purified from serum by dimethylformamide precipitation and was shown to be homogeneous by a variety of electrophoretic techniques. 2. The molecular weight of vitellogenin was estimated by gel filtration to be about 6x10(5). The chemical constituents of vitellogenin were determined and lead to the characterization of this protein as a serum calcium-binding glycolipophosphoprotein. 3. The extractable lipid accounted for 12% of vitellogenin. Gas-liquid-chromatographic analysis of the saponified lipid moiety showed the presence of palmitic acid, palmitoleic acid, stearic acid, oleic acid and linoleic acid in the molecular proportions 6.8: 1.5: 1.0: 3.6: 1.4. 4. The carbohydrate moiety consisted of 0.4g of hexose, 0.77g of hexosamine and 0.18g of sialic acid/100g of vitellogenin. 5. The calcium and phosphorus contents were 0.85 and 1.65g/100g of vitellogenin respectively. 6. Serum from oestrogen-treated animals injected with (45)CaCl(2) contained 9.7 times the radioactivity present in serum from untreated (45)CaCl(2)-injected animals. Of the radioactivity due to (45)CaCl(2) in the serum of oestrogen-treated animals 72% was non-diffusible on dialysis. Of this activity 65.4% was associated with the vitellogenin band on cellulose acetate electrophoresis.


Plasma structural lipids in groups at high and low risk to atherosclerosis.


Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine.


The distribution of C17 fatty acids in the liver of a child with propionicacidaemia.


Changes in fatty acid patterns in bovine plasma.


Ketone-body utilization by adult and suckling rat brain in vivo. 1. Ketone-body utilization in fed and starved adult and suckling rats has been investigated by measuring arterio-venous differences across the brain. Venous blood was collected from the confluence of sinuses and arterial blood from the femoral artery in adult rats and by cardiac puncture in suckling rats. 2. During starvation the arterio-venous difference of ketone bodies increased in proportion to their concentrations in the blood and reached a value of 0.16mm at 48h. At a given concentration of the respective ketone bodies the arterio-venous differences of acetoacetate were about twice those of 3-hydroxybutyrate. 3. Fed rats in which the concentrations of ketone bodies were raised by intravenous infusion of sodium acetoacetate had the same arterio-venous differences as starved rats at corresponding ketone-body concentrations. Thus the ability of the rat brain to utilize ketone bodies is independent of the nutritional state. 4. The concentrations of glucose, acetoacetate and 3-hydroxybutyrate were much lower in the brain than in the arterial blood. The measured (blood concentration)/(brain concentration) ratio was 4.4 for glucose, 4.5 for acetoacetate and 8.1 for 3-hydroxybutyrate in 48h-starved rats. 5. The mean arterio-venous difference of glucose across the brain was 0.51mm in fed rats and 0.43mm in 96h-starved rats. 6. Conversion of glucose into lactate rose from negligible values in the fed state to 0.2mm after 48h starvation and decreased to zero after 96h starvation. 7. In 16-22-day-old suckling rats the arterio-venous differences of ketone bodies across the brain were also proportional to the ketone-body concentration, but they were about 3-4 times greater than in adult rats at the same blood ketone-body concentration. 8. Arterio-venous differences of glucose were about the same in adult and suckling rats. 9. The brain of fed suckling rats formed more lactate from glucose than fed adult rats. 10. The results indicate that ketone bodies are major metabolic fuels of the brain of the suckling rat under normal conditions.


The occurrence of 6-deoxy-L-altrose in the lipopolysaccharide of Yersinia enterocolitica.


Polyamine oxidase in higher plants.

Polyamine oxidase in higher plants.


Solubilization of pig lymphocyte plasma membrane and partial separation of some of the components.


The mechanism of action of yeast invertase.


Some aspects of the effects of electrostatc attraction and of water-entropy changes on the helical stability of deoxyribonucleic acid.


Effect of proteolytic enzymes on deoxyribonuclease.


Methylation of mu2 bacteriophage ribonucleic acid by the carcinogen N-methyl-N-nitrosourea: evidence for O-methylation.


The uptake of calcium from urine in vitro by powdered phosphates and oxalates.


Studies on aetiology of urolithiasis in Karachi.


Fucose in urine of fasting human subjects.


The detection of heterozygotes for homocystinuria by oral loading with L-methionine.


The metabolism by rats of phenylmercury acetate.


C29-carboxylic acid intermediates of cholesterol biosynthesis in rat liver.


The effect of dietary cholesterol on cholesterol biosynthesis and other processes in mammalian liver.


The identification of 17 alpha-hydroxy-17 beta-methyl-androsta-1,4-dien-3-one as a metabolite of 17 beta-hydroxy-17 alpha-methylandrosta-1,4-dien-3-one in man.


Exchange of sterols between rat brain membranes.


Further studies on the biosynthesis of androsta-5,16-dien-3- -ol and the subcellular location of the site of biosynthesis.


The enzymic degradation of alkyl-substituted gentisates, maleates and malates. 1. Cell-free extracts, prepared from a non-fluorescent Pseudomonas grown on m-cresol, oxidized gentisate and certain alkyl-substituted gentisates with the consumption of 1 mol of oxygen and the formation of 1 mol of pyruvate from 1 mol of substrate. 2. In addition to pyruvate, malate was formed from gentisate; citramalate was formed from 3-methylgentisate and 4-methylgentisate; 2,3-dimethylmalate was formed from 3,4-dimethylgentisate. 3. One enantiomer, d-(-)-citramalate, was formed enzymically from 3-methylgentisate, 4-methylgentisate and citraconate. l-(+)-Citramalate was formed from mesaconate by the same extracts. When examined as its dimethyl ester by gas-liquid chromatography, enzymically formed 2,3-dimethylmalate showed the same behaviour as one of the two racemates prepared from the synthetic compound. 4. Maleate, citraconate and 2,3-dimethylmaleate were rapidly hydrated by cell extracts, but ethylfumarate and 2,3-dimethylfumarate were not attacked. 5. Cell extracts oxidized 1,4-dihydroxy-2-naphthoate to give pyruvate and phthalate. 6. Alkylgentisates were oxidized by a gentisate oxygenase (EC 1.13.1.4) present in Pseudomonas 2,5. The ring-fission products were attacked by maleylpyruvase, but not by fumarylpyruvase, and their u.v.-absorption spectra were those expected for alkyl-substituted maleylpyruvates. 7. When supplemented with ATP, CoA, succinate and Mg(2+) ions, an enzyme system from cells grown with 2,5-xylenol formed pyruvate from d- but not from l-citramalate. Extracts from cells grown with dl-citramalate or with itaconate attacked both d- and l-citramalate; other alkylmalates were cleaved in similar fashion to give pyruvate or 2-oxobutyrate. 8. These results accord with a general sequence of reactions in which the benzene nucleus of an alkylgentisate is cleaved to give an alkyl-substituted maleylpyruvate. The ring-fission products are hydrolysed to give pyruvate, plus alkylmalic acids which then undergo aldol fissions, probably as their CoA esters. In Pseudomonas 2,5 several homologous sequences of this general type appear to be catalysed by a single battery of enzymes with broad substrate specificities, whereas the metabolic capabilities of the fluorescent Pseudomonas 3,5 are more restricted. 9. Intact cells of both organisms metabolize d-malic acid by reactions that have not been elucidated, but are different from those which degrade alkylmalates.


Methods and problems in the study of plasma triglyceride metabolism in man.


The metabolism of plasma cholesterol.

The metabolism of plasma cholesterol.


Kinetic studies of the N-demethylation of ethylmorphine by a cytochrome P-450-dependent enzyme system in human liver microsomes.


The electrophoretic mobilities of native and chemically modified human placental alkaline phosphatase isoenzymes.


Characterization of an alkaline phosphatase from rat heart.


Protease and ribonuclease activities in bovine pituitary lobes.


Relationships between kinetic properties and structure of caeruloplasmin substrates.


Patterns of serum gamma G-globulin heterogeneity in health, rheumatoid arthritis and cancer.


Some simple and rapid thin-layer chromatographic methods for clinical purposes.


Nutritional and endocrine factors influencing plasma triglyceride metabolism.


The vectorial release of nascent immunoglobulin peptides. A microsomal preparation from a mouse plasmacytoma, MOPC 47A, that secretes immunoglobulin A was used to study the release of nascent immunoglobulin peptides in vitro. Nascent chains were released with puromycin and characterized with specific antiserum against the immunoglobulin product of the tumour. When the tissue had been prelabelled with [(3)H]leucine the experiments were complicated by the large background of completed radioactive polypeptides in the microsomal preparation. Up to one-third of the released radioactivity in the microsomal preparation could be recognized as immunoglobulin. With [(3)H]-puromycin as the radioactive label, however, the results are much easier to interpret, although the proportion of released radioactivity that can be identified as immunoglobulin is lower (up to one-tenth). Both types of experiment demonstrate that all of the recognizable nascent immunoglobulin chains remain in association with the microsomal vesicles after release from the ribosomes.


The biosynthesis of galactofuranosyl residues in galactocarolose. 1. Cell-free extracts of Penicillium charlesii G. Smith were used in a study of the biosynthesis of the galactofuranose polymer, galactocarolose. 2. UDP-glucose and UDP-galactopyranose were precursors of galactocarolose and it was shown that the galactofuranose residues in the polymer were formed from glucose without fission of the hexose carbon chain. 3. A new nucleotide, UDP-alpha-d-galactofuranose, was formed by the system and was a major product when polymer synthesis was inhibited by F(-) or Zn(2+); the nucleotide was isolated and its structure determined. 4. UDP-alpha-d-galactofuranose was efficiently utilized for polymer synthesis and shown to be formed from the pyranose nucleotides. 5. A route for the biosynthesis of galactocarolose, involving a novel ring contraction of the hexose residue while still attached to the nucleotide, is proposed.


Physical chemistry of calcium stone formation.


Crystallographic studies on the formation of renal calculi.


The binding of cyanide to ferroperoxidase. 1. The equilibrium and kinetics of cyanide binding to ferroperoxidase were investigated. At pH9.1 the equilibrium and kinetic measurements agree closely and disclose a single process with an affinity constant of 1.1x10(3)m(-1) and combination and dissociation velocity constants of 29m(-1).s(-1) and 2.5x10(-2)s(-1) respectively. 2. At pH values below 8 the affinity constant falls until at pH6.0 the ferroperoxidase.cyanide complex is no longer formed. This is shown to be associated with the formation of ferriperoxidase.cyanide complex in the mixture even in the presence of excess of sodium dithionite. 3. Rapid-pH-jump experiments show a fast pseudo-first-order interconversion between ferroperoxidase.cyanide complex at pH9.1 and ferriperoxidase.cyanide complex at pH6.0. 4. The kinetics of binding of cyanide to dithionite-reduced peroxidase at pH6.0 are complicated and radically different from those observed at pH9.1. 5. Above pH8 the change of affinity constant with pH is consistent with the undissociated species, HCN, being bound by the ferroperoxidase. The enthalpy for this process measured both by equilibrium and kinetic methods is about -8kcal/mol. 6. The binding of cyanide to reconstituted peroxidases, proto, meso and deutero, was investigated. 7. The results are discussed in relation to known data on cyanide binding to other haemoproteins.


An improved procedure for the isolation of 3-phosphoglycerate kinase from yeast. 3-Phosphoglycerate kinase has been isolated from yeast by a new procedure. Over 1g was obtained from 450g of granulated baker's yeast; it had a specific activity of up to 940units/mg at 30 degrees C. Six distinct crystalline forms have been grown, at least one of these being suitable for X-ray diffraction studies. The crystalline preparation is pure, judged by starch-gel or sodium dodecyl sulphate-polyacrylamide-gel electrophoresis; the latter method indicating that the enzyme is monomeric, with a molecular weight near to 50000.


Primary hyperoxaluria.

Primary hyperoxaluria.


The metabolic basis of uric acid stone formation.


Isoelectric focusing of proteins in the native and denatured states. Anomalous behaviour of plasma albumin. 1. An analytical technique of isoelectric focusing in thin layers of polyacrylamide gel has been used to determine the isoelectric point, pI, of several proteins in the presence and in the absence of concentrated urea. 2. The presence of urea did not greatly affect pI except for bovine plasma albumin, where an increase of approx. 1pH unit was found. 3. Evidence is presented that this change in the pI of bovine plasma albumin is due to the normalization of certain ionizable groups on unfolding of the protein in urea. 4. Evidence is also presented that prolonged exposure of bovine plasma albumin to urea results in intramolecular disulphide interchange and that, on removal of urea, the new patterns of disulphide bonding stabilize abnormal conformations with pI values intermediate between those of the native and denatured states. 5. The studies demonstrate heterogeneity in bovine plasma albumin based on primary-sequence differences. 6. Isoelectric focusing of proteins in urea appears to be useful in the study of various aspects of protein structure.


Amino acid metabolism in cystinuria.

Amino acid metabolism in cystinuria.


Potentiation of gastric acid response to increasing doses of pentagastrin by subthreshold dose of metacholine in heidenhain pouch dogs.


Cardiac rehabilitation in Britain (1970).


Some aspects of the early evolution of the Appointed Factory Doctor service.


Decompression sickness in caisson workers.


Nutritional and environmental studies on an ocean-going oil tanker. 3. Energy balances and physique.


Studies on the diagnosis and pathogenesis of Raynaud's phenomenon of occupational origin.


Bronchitis in men employed in the coke industry.


A comparative study of respiratory function in female non-smoking cotton and jute workers.


Effect of extremes of temperature and humidity on the goblet cell count in the rat airway epithelium.


Excretion of hippuric acid and m- or p-methylhippuric acid in the urine of persons exposed to vapours of toluene and m- or p-xylene in an exposure chamber and in workshops, with specific reference to repeated exposures.


Psychological picture of manifest and latent carbon disulphide poisoning.


Excretion of organic chlorine compounds in the urine of persons exposed to vapours of trichloroethylene and tetrachloroethylene.


Determination of lead in capillary blood using a paper punched disc atomic absorption technique. Application to the supervision of lead workers.


Nail damage in spray operators exposed to paraquat.


Ophthalmic arterial and venous pressures. Effects of acute intracranial hypertension.


Pseudo-capsular exfoliation in the Bantu of South Africa. I. Early or pre-granular clinical stage.


Ocular manifestations in angiokeratoma corporis diffusum (Fabry).


Visual field analyser and threshold.

Visual field analyser and threshold.


Ophthalmic lesions due to pine-flower pollen.


The early and late results of surgical treatment for Crohn's disease.


Conservative surgery in 100 patients with bleeding peptic ulcer.


Elective lymph-node dissection for melanoma.


On the importance of intracranial air.

On the importance of intracranial air.


Below- and through-knee amputations in ischaemic disease.


Biliary-tract disease in Malaya.

Biliary-tract disease in Malaya.


The effect of short-term exposure to carbon monoxide on platelet stickiness.


Pancreatic secretion after selective and truncal vagotomy in the dog.


Internal sphincterotomy and haemorrhoidectomy in acute haemorrhoids. Its value in reduction of postoperative pain.


The operative diagnosis of carcinoma of the pancreas.


Malignant oncocytoma of the parotid gland.


Clinical trial of the effects of drainage and antibiotics after appendicectomy.


Venous thrombosis: a practical method of prevention.


The measurement of insensible water-loss.


Plasma growth hormone levels in relation to trauma and environmental temperature.


Exocrine secretory responses of the pancreas to insulin and to a standard meal in dogs.


The action of progesterone on venous smooth muscle.


Barbiturate anaesthesia for extended periods of time and the maintenance of some physiological parameters.


Pulmonary perfusion defects in postoperative chest infections.


The ultrastructure of joint cartilage and its alteration in disease.


A new design concept for corrosion-resistant orthopaedic implants.


Factors affecting the incidence of hypothyroidism after surgery for thyrotoxicosis.


Cytological biopsy of salivary glands.

Cytological biopsy of salivary glands.


Primary suppurative parotitis.

Primary suppurative parotitis.


The role of the Mastership of Surgery.

The role of the Mastership of Surgery.


Treatment of early breast cancer: the organization of a 'national trial'.


Histological features of the primary tumour contributing to the prognosis in breast cancer.


Effect of radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast.


Urinary hydroxyproline excretion in patients with breast cancer.


Radio-immunoassay of gastrin also measures degradation products.


Plasma-gastrin levels in patients with duodenal ulcer after insulin hypoglycaemia.


The release of gastrin in response to insulin, food and meat extract (Oxo).


The effect of antral acidification on acid secretion stimulated by pentagastrin.


Bile reflux, gastric secretion, and heartburn.


Gastroduodenal motility patterns associated with pyloric reflux.


The effect of pH and infusion volume on organ preservation.


A system of regional renal hypothermia.

A system of regional renal hypothermia.


The progressive osmotic effect in organ preservation.


The fate of the spleen after partial or total dearterialization.


The composition of hepatic and gallbladder bile in patients with gall-stones.


Bile composition in dogs with and without gall-bladders, and the effect of vagotomy.


The effect of cholecystectomy on the size of the bile-salt pool in the dog.


A comparison of the value of measurement of flow and pressure as aids to bile-duct surgery.


Gastro-intestinal hormones and electrical activity in the terminal ileum.


The role of extrinsic autonomic innervation in the tone and behaviour of short segments of the small intestine in the rabbit and the dog.


Cardiac function in haemorrhagic shock.

Cardiac function in haemorrhagic shock.


The adjuvant effect of hyperthermia on the response of the VX2 carcinoma in rabbits to methotrexate or radiotherapy.


A study of blood coagulation factors in patients having reconstructive surgery to the arteries of the lower limbs.


Endocrine ablation and the immune response.


Small-vessel disease in patients with abnormal insulin secretion: a new concept.


An in vitro evaluation of stenosis and incompetence in prosthetic mitral valves.


The completeness of cellular destruction within a cryolesion.


Bowel habit after truncal, selective, and highly selective vagotomy in man.


A randomized trial of selective and parietal cell vagotomy without a drainage procedure.


Gastric secretion and emptying before and after parietal cell vagotomy, with and without pyloroplasty.


The insulin test after highly selective vagotomy without drainage for duodenal ulcer.


An evaluation of Burge's electrical test for completeness of vagotomy.


The ultrasonic detection of incompetent perforating veins.


Doppler ultrasound measurement of supra-orbital artery blood-pressure.


Peripheral arteriography timed by an ultrasonic blood-velocity detector.


Clinical diagnosis of leg-vein thrombosis and pulmonary emboli in relation to potentially preventable deaths from emboli.


Prevention of postoperative deep-vein thrombosis using heparin.


Abnormal blood viscosity as a possible aetiological factor in deep-vein thrombosis.


Deep-vein thrombosis in patients with fractured neck of femur.


Complete transection of the stomach and pancreas as a result of blunt trauma.


Surgical correction of intrarenal arteriovenous fistula with preservation of the kidney.


A comparative study of mescaline and 3,4-dimethoxy-phenylethylamine in isolated brain mitochondria and brain homogenate.


The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.


Anatomical distribution of the hippocampal fibers afferent to the lateral septal nucleus.


Acetylcholinesterase in non-cholinergic neurones: a histochemical study of dorsal root ganglion cells in the rat.


Age differences in polyamines associated with microsome preparations from rat brain.


Quantitative histological analysis of the cerebellar cortex in the cat. 3. Structural organization of the molecular layer.


The pre-transfusion assay of cryoprecipitate.


The representation of extraocular muscles in the oculomotor nuclei: experimental studies in the cat.


Effect of splenectomy on the activity of drug-metabolizing enzymes in the liver of rats.


The influence of muscular work on the capillary density in the heart and skeletal muscle of pigeon (Columbia livia dom.).


The effect of temperature on sodium movements in rat uteri and a model for control of their ion content.


Effects of inhibitors of active transport on  22 Na and  42 K movements and on nucleotide levels in rat uteri at 25 degrees C.


Inhibitory effect of salmon and other calcitonins on calcium release from mouse bone in vitro.


The action of diazoxide on isolated vascular smooth muscle electrophysiology and contraction.


The effect of sonic vibration on isolated human iliac arteries.


Thyroid status in relation to catecholamines in cold and warm environment.


Biochemical basis of heart function. 3. Influence of isoproterenol on the norepinephrine stores in the rat heart.


Transmembrane K +  and Cl -  activity gradients for the muscle fiber of the giant barnacle.


Evidence for the heterogeneous distribution of chloride in the barnacle muscle.


Effect of oxygen on tissue temperature gradients in the African guinea hog.


Degeneration and regrowth of adrenergic nerve fibers in the rat peripheral tissues after 6-hydroxydopamine.


Erythrocyte flow in tubes of capillary size.


Measurement of citrate synthase activity in human fibroblasts.


Familial de Lange syndrome. Report of three cases in a sibship.


Consultation-liaison psychiatry in general hospital.


Unidentified neuroglia potentials during propagated seizures in neocortex.


Nucleic acids and protein synthesis after denervation of the rat hemidiaphragm.


Cortical and subcortical responses to flicker in cats.


Intracellular responses of dorsal horn cells to cutaneous and sural nerve A and C fiber stimuli.


Enhancement by ethanol of visually evoked responses in the goldfish optic tectum.


Influence of antidromic callosal volleys on single units in visual cortex.


Cholinesterase activity of muscle fibers and motor end plates: comparative studies.


Developmental protein changes in normal and chromatolytic facial nerve nuclear regions.


Spinal and supraspinal factors in voluntary movement.


The immunological response to transplanted sympathetic ganglia.


Reorganization of retinotectal projection following surgical operations on the optic tectum in goldfish.


Visual processing in the split-brain cat: one versus two hemispheres.


Concepts of social sex roles among Chilean adolescents.


Polyacrylamide gel electrophoresis in the investigation of rat neurophysins.


Hyperparathyroidism--surgical implications.


The new Federal narcotic and dangerous drug law.


International structures in science.

International structures in science.


Function of the thyroid and the host-parasite relation in murine schistosomiasis mansoni.


Ultraviolet light, DNA repair and skin carcinogenesis in man.


Temperature-sensitive mutants of Mycoplasma pneumoniae. II. Response of hamsters.


Mediators produced by sensitized lymphocytes.


Biochemical effects of cholera enterotoxin. II. Glucose metabolism in the intestine of the infant rabbit.


Pathogenesis of epizootic hemorrhagic disease. I. Blood coagulation during viral infection.


Effect of polybasic antibiotics and sulfaguanidine on absorption and excretion of cholesterol and bile salts.


Isolation of Toxoplasma gondii from the feces of naturally infected cats.


Nutritional and biochemical aspects of host-microflora interaction. Introductory remarks.


Giardiasis in travelers.

Giardiasis in travelers.


Strange hemolytic anemia and pancreatic acinar atrophy and fibrosis.


The protective effects of feeding on the hepatic ultrastructure of rats treated with hypoglycin.


Pathology of diabetic neuropathy.

Pathology of diabetic neuropathy.


Malignancy in natural and experimental hepatic cysts: experiments with aflatoxin in rats and the malignant transformation of cysts in human livers.


Effect of 7-hydroxymethyl-12-methylbenz(a)anthracene on the adrenal gland of the foetal and postnatal rat.


Argentaffin and argyrophil cells in the appendix.


The cortisone-induced wasting disease of newborn rats: histopathological and autoradiographic studies.


Membrane-bounded intranuclear structures in hepatocytes after exposure to sodium tetraphenyl boron.


A longitudinal cystic duplication of the gall bladder.


Parietal lobe arteriovenous aneurysm and unilateral facial angioma.


The response of the fenestrated vessels of the small intestine of rats to application of mustard oil.


Heart block due to epithelial heterotopia.


The effects of histamine and bradykinin on the post-capillary venule.


Experimental turpentine arthritis: measurement of treated and untreated inflammatory response by the accumulation of 125I-albumin.


Neonatal induction of rat neural tumours by ethylnitrosourea.


Ganglioneuroblastoma in an adult human albino.


Prognosis in breast cancer based on an evaluation of 20 primaries giving recurrence 10 years or more after operation.


The ultrastructure of the endometrial stromal cell.


The ultrastructure of molar trophoblast.


The ellipsoids (sheaths of Schweigger-Seidal) of the human spleen in various pathological conditions.


Quantitative studies of bone growth with a modified tetracycline-labelling technique.


The early progression of papillary transitional-cell carcinoma.


The morphological basis of atrial fibrillation in man.


Pre-irradiation and the regeneration of injured skeletal muscle.


A light- and electron-microscope study of the pulmonary lesions induced in rats by paraquat.


Experimental ulceration of the colon induced by sulphated products from sources other than seaweed.


Electron-microscope changes in Rowson-Parr virus infection.


The ultrastructure and histochemistry of sarcoid granulomas.


Laboratory observations of hereditary angio-oedema and its treatment.


A case of Coombs-negative haemolytic anaemia.


An acceptance test of tape-recorded tuition at the microscope.


The effect of x-rays on lipids, phospholipids and cholesterol of the mouse testis.


Spermatic vein testosterone in boars during puberty.


Pituitary follicle-stimulating hormone in immature guinea-pigs and hamsters and in female rats after neonatal treatment with testosterone.


Quantitative changes in myometrial activity in the guinea-pig during pregnancy.


Characterization of boar seminal plasma, vesicular secretion and epididymal plasma proteins by gel disc electrophoresis and isoelectric focusing on polyacrylamide.


Fine structure localizations of acid phosphatase in rabbit and bull sperm heads.


Protease activity in rabbit uterine secretion 24 hours before implantation.


Transport of microspheres by the human oviduct in vitro and the effect of treatment with megestrol acetate.


The permeability of the 'blood-testis' barrier to ferrocyanide.


Sex chromatin in the amnion of the pig.

Sex chromatin in the amnion of the pig.


Haemolysis following copulation in male rats.


Effect of epinephrine on implantation and foetal survival in the rabbit.


Differential sensitivity of preimplantation mouse embryos in vitro to oestradiol and progesterone.


Biochemical studies with human semen. 1. A correlative study of some constituents with the count and motility of spermatozoa.


Temporary sterilization of the male (human subject) by an intravasal contraceptive device (IVCD).


Variations in testicular cholesterol following long-term treatment with oestradiol.


Morphology of spermatozoa in relation to the fertility of animals.


Effects of partially purified salmon pituitary gonadotrophin on re-initiation of spermatogenesis in the long-term hypophysectomized catfish, Heteropneustes fossilis.


Dynamics of phospholipid metabolism in the sexual segment and kidney of the Indian house lizard, Hemidactylus flavivridis Ruppell.


The cervix and fertility control.

The cervix and fertility control.


Time sequences of action of oestrogen on nucleic acid and protein synthesis in the uterus and blastocyst during delayed implantation in the rat.


The effect of an intrauterine contraceptive device on the mast cell content of the human myometrium: a preliminary report.


Fate of (6,7- 3 H) norethynodrel in women.


Biosynthesis of proteins in human placenta from normal and toxaemic pregnancies.


Pharmacokinetics of contraceptive steroids.


Effect of steroids, pituitary inhibitor or pituitary implants on ovarian compensatory hypertrophy in adrenalectomized, hemispayed albino rats.


Evaluation of gonadotrophin analyses in male hypogonadism.


Function of the human ovary during pregnancy as revealed by the histochemical, biochemical and electron microscope techniques.


Pituitary functions as judged by urinary excretion of FSH and LH in normal married young women cyclically treated with 0.5 mg megesterol acetate.


Long-acting injectable therapy for fertility control.


Blood pressure with hormonal contraception.


Studies on the in vitro formation of monoiodotyrosine by soluble supernatant of pigeon thyroid gland.


Gynaecography as a diagnostic aid in infertility.


Comparison of the effects of methallibure and thiourea on the testis, thyroid and adenohypophysis of the adult and juvenile guppy, Poecilla reticulata Peters.


Premature menopause.

Premature menopause.


Joint action of clomiphene citrate and human pituitary gonadotrophihs.


Semi-quantitative estimation of human chorionic gonadotrophin in urine by immunological and biological assays during pregnancy.


Hormonal control of gestation in the intact rat. Studies using specific antigonadotrophins.


Primary immune response of rats and rabbits treated with Enovid.


General practice.

General practice.


Effect of Ovulen and Depo-Provera on primary and secondary immune response in mice and rats.


Cerebrovascular disease occurrence in Australia.


Syncope: pathological physiology: differential diagnosis and treatment (I).


Where resident parents are welcome.

Where resident parents are welcome.


End-stage renal failure.

End-stage renal failure.


Artificial cardiac pacing--the vital stimulus.


Occupation and lung cancer.

Occupation and lung cancer.


Careers in nursing. Nursing in the Senior Service.


Genetic counseling.

Genetic counseling.


The changing face of nursing.

The changing face of nursing.


The learning process in student nurses. 1. Some problems and variables.


E.N.T. case of the month.

E.N.T. case of the month.


Fatal auto-immune hemolytic anemia complicating lymphoma. Report of three cases.


Maternal deaths: unusual cases--wtih comment of consulting obstetrician and gynecologist.


The effect of clomiphene citrate in chickens. 1. Androgenic and estrogenic activity.


Interrelationships between methionine and vitamin B6 in chick diets.


Single comb white Leghorn cockerels versus broiler chicks for use in phosphorus assays.


Specific inhibition of splenic cells migration in chickens sensitized to delayed hypersensitivity.


New York State computerized proficiency testing program in exfoliative cytology: evaluation.


The p-n-p transistor used exponentially to linearize the voltage output of the P CO2  physiological electrode.


Defects of gluthathione reducing and synthetizing reactions in the red cells.


An improved cell volume analyzer.

An improved cell volume analyzer.


Flowmeter and 133 xenon clearance studies of the blood flow in the internal mammary artery after intramyocardial implantation in the dog.


Isolation and immunological study of thymic lymphocytic inhibitory factors.


Beta-mercaptoethanol induced fatty liver.


Distribution and metabolism of adriamycin in mice. Comparison with daunomycin.


Serum lipids, smoking and body build. Study of 7,972 actively employed males.


Study of the level of production of cortisol, corticosterone, aldosterone and deoxycorticosterone in 4 cases of congenital adrenal hyperplasia due to II beta-hydroxylase deficiency.


Thromboelastographic examination (TEG) in uranium miners.


Toward a new organizational structure for American pharmacy.


Stability of sodium ampicillin solutions in the frozen and liquid states.


A variant form of branched-chain keto aciduria.


Stability of parenteral solutions of sodium cephalothin, cephaloridine, potassium penicillin G (buffered) and vancomycin hydrochloride.


The current status of the prefilled syringe.


Reorganizing the professional staff to meet new pharmacy challenges.


The incidence of drug-diagnostic test interferences in outpatients.


Partitioning phenomena in dosage form and biopharmaceutical design. I. Prognostic significance of partition coefficients.


Heparin therapy by continuous intravenous infusion.


Recent studies on mycobacterial differentiation by means of pyrolysis-gas-liquid chromatography.


The use of Bohr integral isopleths in the study of arterial oxygen saturation in chronic pulmonary tuberculosis.


Spirometric standards for noraml children and adolescents (ages 5 years through 18 years).


Oxyhemoglobin affinity in chronic pulmonary granulomatosis (sarcoidosis) and fibrosis.


Rifampin alone and combined with other drugs in Mycobacterium kansasii and Mycobacterium intracellulare infections of mice.


Interaction of Tween 80 detergent with mycobacteria in synthetic medium. I. Effect of Tween 80 on the growth and turbidimetric response of Mycobacterium avium cultures.


Mycobacterium fortuitum as a pathogen. A case report.


Induction of phages from lysogenic mycobacteria by means of ultraveiolet irradiation.


The isolation of Mycobacterium xenopi from granulomatous lesions in swine.


The tuberculin skin test. A statement by the Committee on Diagnostic Skin Testing.


Chemoprophylaxis of chronic bronchitis. A statement by the Committee on Therapy.


Juvenile hormone-controlled synthesis of female-specific protein in the cockroach Leucophaea maderae.


Studies on modified hemoglobins. 1. Preparation and properties of a hemoglobin containing heme only in  -chains.


Microsomal rat liver UDP glucuronyltransferase: effects of piperonyl butoxide and other factors on enzyme activity.


The effect of pH on the kinetic parameters and mechanism of beef liver monoamine oxidase.


Properties of DNA isolated from tissues of calves treated with S-(1,2-dichlorovinyl)-L-cysteine. 1. Chemical and physical properties.


Isolation and structural properties of cytoplasmic glycerol-3-phosphate dehydrogenase from rat liver.


Multiple molecular forms of cytoplasmic glycerol-3-phosphate dehydrogenase in rat liver.


Comparison of cytoplasmic glycerol-3-phosphate dehydrogenase from rat liver and muscle.


Control of photosynthesis by Mg 2+ .

Control of photosynthesis by Mg 2+ .


Protein synthesis during germination of Peronospora tabacina (Adam) conidia.


Histone methylation. Partial purification of two histone-specific methyltransferases from rat thymus nuclei preferentially methylating histones F2a 1  and F3.


The thiobarbituric acid reaction in relation to fatty livers.


A role of acetoacetyl-CoA synthetase in acetoacetate utilization by rat liver cell fractions.


Energy conservation in detergent-treated mitochondria and purified succinate-cytochrome c reductase.


Fluorescence of synthetic DNA's at room temperature and neutral pH.


The subunit structure of human placental 17 -estradiol dehydrogenase.


Differences between CNBr peptides of soluble and insoluble bovine collagens.


Cholesterol esterase--a polymeric enzyme.


Isolation of chromatin bearing nascent RNA from nuclei of sea urchin embryos.


Identification of one of the L-serine dehydratase isoenzymes from rat liver as L-homoserine dehydratase.


Amino acid sequence of the Peptostreptococcus elsdenii flavodoxin.


Amino acid sequence of toxin A from the venom of the Indian cobra (Naja naja).


RNA polymerase from Micrococcus luteus: comparative effect of ribosyl and deoxyribosyl oligomers on the homopolymer. Directed reaction.


Ultraviolet light-induced changes in ribonuclease conformation.


Effect of polyethylene glycol on heat inactivation of the Hill reaction.


Binding of testosterone to cytoplasmic components of the immature rat uterus.


Copurification of carbamoyl phosphate synthetase and aspartate transcarbamoylase from mouse spleen.


Timing of growth regulator responses in peas.


The inadequacy of 6 M guanidine hydrochloride as a dispersive agent for membrane proteins.


Ion and macromolecular transport in the alveolar macrophage.


Stimulation of basic amino acid uptake by certain neutral amino acids in isolated intestinal epithelial cells.


Light-induced electrical effects in a retinal bilayer lipid membrane.


Characterization of the active hexose transport system of Chlorella vulgaris.


Membrane transport in the rabbit alveolar macrophage. The specificity and characteristics of amino acid transport systems.


Comparison of the carbohydrate portion of membrane H-2 alloantigens isolated from spleen cells and tumor cells.


Permeability of pea chloroplasts to alcohols and aldoses as measured by reflection coefficients.


Hemolysis induced by Prymnesium parvum toxin. Kinetics and binding.


Evaluation of kinetic parameters for uptake of amino acids by cells: effect of insulin on the accumulation of aminoisobutyrate and cycloleucine by isolated rat diaphragm muscle and chick embryo hearts.


Daily rhythmic change in the transport of histidine by everted sacs of rat small intestine.


Na + -K +  discrimination by "pure" phospholipid membranes.


Effect of substrate structure on coupling ratio for Na + -dependent transport of amino acids.


The reaction of mercuric ions with encapsidated and isolated RNA of Tomato Bushy Stunt Virus.


Properties of nucleic acid representations. I. Topology.


Recent progress in the sequence determination of bacteriophage MS2 RNA.


The effect of iron and haematin on the killing of staphylococci by rabbit polymorphs.


The effect of antithymocyte serum on golden hamsters and rats infected with Plasmodium berghei.


Ultrastructure and behaviour of platelet thrombi in injured arteries.


The role of digitonin in the activation of serum thrombotic accelerator.


The nephrotoxicity and histology of cephaloridine and its polymers in rats.


Morphology of local tissue damage in experimental snake envenomation.


Inhibition by lymphocyte nuclei of DNA and RNA synthesis in stimulated lymphocytes and leukaemic cells.


Toxic effects of Borassus Flabellifer (palmyrah palm) in rats.


Factors affecting the toxicity of the element indium.


Metabolic and histopathological consequences of a fatty liver during the acute stages of myocardial infarction in rats.


Cause of death.

Cause of death.


Critical cytoplasmic mass and the initiation of the proliferative response in the rat liver.


Pacemakers for heart block.

Pacemakers for heart block.


Neurology of the leukaemias and lymphomas.


"Challenges for change".

"Challenges for change".


Herpetic whitlow: a medical risk.

Herpetic whitlow: a medical risk.


Pregnancy testing.

Pregnancy testing.


Volvus of the stomach.

Volvus of the stomach.


Serum gastrin and the antral mucosa in atrophic gastritis. The gastric antral mucosa was studied histologically in 22 patients with atrophic gastritis, of whom 11 had high levels and 11 had normal levels of serum gastrin. The antrum was graded histologically from normal to grade 3 gastritis. All patients with hypergastrinaemia (nine seropositive and two seronegative for parietal cell antibody) had either a normal antrum or minimal (grade 1) antral gastritis. In contrast all but one patient without raised serum gastrin (nine seronegative and two seropositive for parietal cell antibody) had severe (grades 2-3) antral gastritis. Thus circulating gastrin levels observed in patients with gastritis and achlorhydria can be directly related to the presence or absence of antral mucosal damage.Comparison of the histological appearances of the antral mucosa with serum gastrin and parietal cell antibody status has provided a basis for the separation of two distinctive forms of atrophic gastritis.


Present status of subclinical intestinal malabsorption in the tropics. A review of the literature on subclinical intestinal disease shows its probable relevance in certain nutritional deficiencies in the indigenous residents of tropical climates. A significant incidence of intestinal disease has been defined among asymptomatic fit-looking adult Nigerians. The results of subsequent investigation into the pathogenesis of this disorder strongly point to hypoalbuminaemia as the important factor capable of producing a biochemically and histologically defined malabsorptive state leading to subnormal nutritional status among members of this community.


Changing sex ratios in diabetes.

Changing sex ratios in diabetes. A survey of sexes and ages in patients attending the Hartlepool diabetic clinic was carried out for the 20-year period 1948-67. The proportion of men aged 50 and over rose from 25.9% in the first decade to 38.2% in the second. An attempt has been made to explain this pronounced and rapid change.


Otolaryngological aspects of Sjögren's syndrome. Twenty-two patients with Sjögren's syndrome uncomplicated by a connective tissue disorder, 31 with Sjögren's syndrome complicated by rheumatoid arthritis, and 21 with rheumatoid arthritis alone were studied with particular reference to changes in the ears and in the upper respiratory and digestive tracts.Epistaxis, soreness and dryness of the throat, dysphagia, and hoarseness were common symptoms, and rhinitis sicca and postcricoid narrowing were not uncommon features of the Sjögren groups. Oesophagoscopy in one patient revealed a web identical to that found in Paterson/Brown Kelly syndrome; none of the patients, however, had an iron-deficiency anaemia or koilonychia. There was an increased frequency of deafness in all groups, and the deafness tended to be conductive in the Sjögren groups and sensorineural in the rheumatoid arthritis group.


Disseminated intravascular coagulation complicating infectious mononucleosis.


Further experience with azathioprine in rheumatoid arthritis. Azathioprine has been shown to reduce the steroid requirements of patients with severe rheumatoid arthritis. Twenty-seven patients treated with azathioprine have now been followed up for 30 months. At the end of this period only 10 were still taking the drug. Maximum steroid reduction occurred within the first 12 months of treatment. Some steroid-sparing effect seemed to persist after the drug was stopped. There was no evidence that azathioprine prevented radiological deterioration. No deaths occurred and toxic effects always reversed on stopping the drug.


Management of ingested foreign bodies in childhood. A total of 660 patients with ingested foreign bodies admitted to the general surgical services in two children's hospitals in Liverpool are reviewed. Endoscopic removal (205 cases) is recommended for all foreign objects impacted in the oesophagus, with the exception of rounded or blunt objects in the lower third, which should be observed for a maximum of 12 hours. The indications for laparotomy for removal of a foreign body (43 cases, 6.5%) are the danger of perforation and failure of progression. The ingestion of a long slender object-for example a hair-grip-in a child under 2 years of age, is an absolute indication for prophylactic operative removal owing to the high incidence of impaction and perforation of the duodenum.


Results in 1,000 cases of therapeutic abortion managed by vacuum aspiration. A prospective study of 1,000 cases of termination of pregnancy by vacuum aspiration is presented and the safety of the method emphasized. By setting up special clinics and an additional weekly operating session, the maximum delay from a request to appointment is 5 days, and, if operation is advised, from appointment to operation a further 7 days.


Elective end-to-side portacaval shunt: results in 64 cases. In a series of 64 cases of elective end-to-side portacaval shunts performed for liver disease the success rate-in that the patient survived with a patent shunt, free of subsequent haemorrhage and severe encephalopathy-was 48%.The early postoperative death rate was 12.5% and the five-year survival 65%. Bleeding from oesophagogastric varices after blockage of the shunt was responsible for at least half of the early postoperative deaths, and most late deaths were due to liver failure. A decreased chance of late survival was associated with age over 40 years, active chronic hepatitis, and with a preoperative history of hepatocellular jaundice.Shunt blockage occurred in 16% of patients, and all bled again from oesophagogastric varices. Shunt block is more likely if the portal vein is calcified or thrombosed, and may be more likely if the portal vein diameter, as shown by splenic venography, is 1.5 cm or less.In survivors with a patent shunt the most serious late complication was chronic, severe portal-systemic encephalopathy, which occurred in 38%. Severe encephalopathy was associated with age over 40 years, a preoperative history of any degree of encephalopathy, diabetes mellitus, and with continued drinking in the alcoholic. Most patients who had portal-systemic encephalopathy in the first year postoperatively developed chronic disabling encephalopathy.A preoperative history of transient mild or moderate ascites did not seem adversely to influence the outcome.


The health visitor.

The health visitor.


Scientific basis of clinical practice: the Birmingham scheme.


The small-for-dates baby. II.

The small-for-dates baby. II.


Coronary deaths -how unexpected?

Coronary deaths -how unexpected?


Digoxin and A-V block.

Digoxin and A-V block.


Antibiotic sensitivity testing.

Antibiotic sensitivity testing.


Pregnancy testing.

Pregnancy testing.


Aluminium and chronic renal failure.

Aluminium and chronic renal failure.


Care of chronic psychotics.

Care of chronic psychotics.


Chorea and the oral contraceptives.

Chorea and the oral contraceptives.


Trimethoprim-sulphamethoxazole mixture in pregnancy.


Aetiology of Bell's palsy.

Aetiology of Bell's palsy.


No smoking and life expectancy.

No smoking and life expectancy.


"Stroke units".

"Stroke units".


Epitaph for the M.C.H.C.

Epitaph for the M.C.H.C.


Hospital information booklets.

Hospital information booklets.


Nephrotoxicity of cephaloridine.

Nephrotoxicity of cephaloridine.


Use of English.

Use of English.


Future of the coroner.

Future of the coroner.


Measurement of iodine concentration in biological material.


An improved automated assay of serum glutamic-oxalacetic transaminase.


An improved autoanalyzer technique for the determination of serum alkaline phosphatase.


Evaluation of chromogens suitable for occult blood in faeces.


Ultracentrifugal characteristics of macroamylasemic serum.


Electrophoretic characteristics of macroamylasemic serum.


The metabolism and placental transfer of oral and parenteral iron chelates.


An automated method for lysozyme assay.

An automated method for lysozyme assay.


Photodensitometry of mouse serum lactate dehydrogenase isoenzymes separated on polyacrylamide gel.


The preparation and identification of various adducts of oxidized homogentisic acid and the development of a new sensitive colorimetric assay for homogentisic acid.


Fluorometric determination of cystine aminopeptidase-oxytocinase in blood serum.


Iso-homovanillic acid determination in human urine.


Origin of synovial fluid lactate dehydrogenase in rheumatoid arthritis.


The binding of  51 Cr with phosphate compounds in chromium labelled red blood cells.


A new micro-method for Na, K, Ca, and Mg determinations in a single serum dilution by atomic-absorption spectrophotometry.


The estimation of plasma albumin by BCG dye binding on the Technicon SMA 12-60 analyser and a comparison with the HABA dye binding technique.


Determination of intestinal alkaline phosphatase in serum by substrate-specificity measurements.


Cholinergic enzymatic activity of cerebrospinal fluid of patients with various neurologic diseases.


The influence of ABO blood groups, secretor status and fat ingestion on serum alkaline phosphatase.


Thin layer chromatographic screening test for amino acid anomalies in urine without desalting using internal standards.


Guanase activity in endemic Balkan nephropathy.


Theoretical considerations in continuous flow analysis.


A specific gas-chromatographic method for the measurement of "steady-state" plasma levels of amitriptyline and nortriptyline in patients.


Albumin as an aid to the interpretation of serum calcium.


The effect of temperature on lactate and 2-hydroxybutyrate dehydrogenase assay.


Phenylpyruvate and o-hydroxyphenylacetate in phenylketonuric urine.


Serum malate dehydrogenase isoenzymes as indicators of severe cellular injury.


Changes in the alkaline phosphatase activity of serum samples after thawing and after reconstitution from the lyophilized state.


On the occurrence of glusulase-hydrolyzable conjugates of 3,4-dihydroxy-phenylacetic and homovanillic acids in human urine.


Familial hypercholesterolemia.

Familial hypercholesterolemia.


Apparent change in the pK' 1  of carbonic acid in plasma in response to acute metabolic acidosis in normal subjects.


Hb-J-Georgia=Hb-J-Baltimore=  2   2  16 Gly leads to Asp.


Sorbitol and mannitol in human urine.

Sorbitol and mannitol in human urine.


Spot tests for rapid diagnosis of poisoning.


Iron ingestions--the Children's Mercy Hospital.


Digital filtering of left ventricular heart volume and calculation of aortic valve blood flow.


Evaluation of two statistics in one sweep of a biomedical data analyzer.


An electrical model to simulate skin dielectric dispersion.


A pilot on-line data system for general practitioners.


Computer approaches to protein structure. 3. Transformation of atomic coordinates.


Simulation of bacterial growth, cell division, and DNA synthesis.


The differentiation of stereoheterotopic groups.


Synthetic polynucleotides. Enzymic synthesis of ribonucleotide terminated oligodeoxynucleotides and their use as primers for the enzymic synthesis of polydeoxynucleotides.


A calorimetric study of the denaturation of lysozyme by guanidine hydrochloride and hydrochloric acid.


Functional properties of human hemoglobin and isolated hemoglobin chains treated with organic mercurials.


Acetylcholinesterase interaction with a lipoprotein matrix.


Quantitative studies on the synthesis in vivo of prostaglandins in the rat. Cold stress induced stimulation of synthesis.


The J blood-group substance of cattle. Studies in animals with J substance in serum and erythrocytes and animals with J substance only in serum.


Studies on the bacteriophage MS2. The untranslated 5'-terminal nucleotide sequence preceding the first cistron.


The genus Candida Berkhout. XI. Electron microscopy and roentgen-phase analysis of cell walls of three strains of Candida guilliermondii (Cast.) Langeron et Guerra.


Selection of high ethanol-yielding Saccharomyces. I. Ethanol tolerance and the effect of training in Saccharomyces cerevisiae Hansen.


Selection of high ethanol-yielding Saccharomyces. II. Genetics of ethanol tolerance.


Effect of uranyl ions on steady-state distribution of monosaccharides in baker's yeast.


Cell-pool tryptophan phases in ergot alkaloid fermentation.


Antimicrobial agents. XI. Microbiol degradation of fungicidin.


Changes in the elimination rate of I 131 -labelled heterologous albumin from the blood of chickens during their postnatal development.


Simultaneous application of radionuclides in tracer experiments.