Immunogenicity of plague vaccines in mice and guinea pigs. The median effective doses (ED(50)) of 28 lots of killed Pasteurella pestis strain 195/P vaccine were determined in mice and guinea pigs. Mice were injected with vaccine alone, whereas guinea pigs received vaccine suspended in incomplete Freund's adjuvant. Potency ratios of vaccines were obtained by comparing the ED(50) of the test with that of a reference vaccine. Mean potency ratios of 1.82 +/- 0.50 in mice and 3.22 +/- 0.56 in guinea pigs were obtained, and the difference between these means was significant, P = <0.01. The number of organisms in the challenge dose did not significantly affect the ED(50) of a vaccine in guinea pigs. However, irrespective of vaccinating route, nearly 1,000 times as much vaccine was required in the absence of adjuvant as in its presence to produce comparable protective indexes in the guinea pig. The response of guinea pigs did not offer any improvement over mice in evaluating the efficacy of plague vaccines.


Standards for the prevention of occupational lead poisoning.


In vitro susceptibility of atypical mycobacteria to rifampin. Atypical mycobacteria (209 strains) were examined for susceptibility to rifampin by the proportion method by using Middlebrook 7H-10 agar. All strains of Mycobacterium kansasii and tap-water scotochromogens were inhibited by 0.25 to 1 mug of the drug per ml. Seventy-six per cent of M. scrofulaceum and 61% of M. intracellulare strains were susceptible to 4 mug/ml or less; 5% of the former and 8% of the latter were resistant to 16 mug/ml. All strains of M. gastri and M. triviale and most strains of M. terrae were sensitive to 1 to 4 mug/ml. Two strains of M. borstelense were both inhibited by 8 mug/ml. Nearly all strains of M. fortuitum were resistant to the drug. The results of this study suggest that rifampin may be a valuable agent for the treatment of many atypical mycobacterial infections.


Biochemical tests for the appraisal of exposure to lead.


Delta-aminolevulinic acid synthetase and adenosine triphosphate activity in acute saturnine intoxication in rabbits.


Lead concentration found in human blood in association with lead colic.


Prevention of long-term sequelae following the absorption of lead.


Occupational exposure to inorganic compounds of lead. Investigation of  -aminolevulinic acid and coproporphyrin excretion rates of persons exposed occupationally for the first time.


The case of the doctor's dog.

The case of the doctor's dog.


Comment on sulfur oxides and pollution.

Comment on sulfur oxides and pollution.


Comment on melathion poisoning.

Comment on melathion poisoning.


An improvement in the plaque assay of rabies virus in chick embryo cells.


Fenspiride--a non-sympathomimetic bronchodilator with anti-allergic activity.


Persistent rubella virus infection in laboratory animals.


Antagonism of the ganglion stimulating and parasympathetic actions of McN-A-343 by pilocarpine.


Observations on models used for the evaluation of antiarrhythmic drugs.


Anticonvulsant effect of trimethadione in mice during continued treatment via the drinking water.


Studies on the acute and chronic depressor actions of nicotine in the rat.


Effect of diphenylhydantoin on hexobarbital sleep time in mice and rats.


Myotonia produced by indoleacetic acid. Studies with related compounds and correlation with drug levels in tissues.


The effect of streptomycin on sodium and potassium currents in myelinated nerve.


Placental transfer of sulfanilamide as determined at constant drug concentrations in the maternal blood.


Effects of tremorine, physostigmine and tremor blocking drugs on brain monoamines.


Effect of clofibrate on lipoprotein lipase.


The influence of some antibiotics on hexokinase and pyruvate-kinase activity in the rat liver and kidney.


Facilitatory effect of amphetamine on learning and recall of an avoidance response in rats.


Theophylline potentiation of norepinephrine activated phosphorylase in normal and hyperthyroid rats.


Teaching sensitivity, specificity and range using the AutoAnalyzer.


The use of stored blood for quality control of automated hematology.


Cirrhosis and bilharzial fibrosis of the liver in Rhodesia.


Malaria due to Plasmodium ovale in Rhodesia.


Physical development of school children in Charter District.


A case report and clinical review of typhoid perforation of the bowel.


Mating types in Saccharomyces: their convertibility and homothallism.


Supersuppressible mutants in Neurospora: mutants at the tryp-1 and tryp-2 loci affecting the structure of the multienzyme complex in the tryptophan pathway.


Structure of the R r  tandem duplication in maize.


Genetic control of alcohol dehydrogenase--a competition model for regulation of gene action.


The presence of a group A variant-like antigen in streptococci of other groups with special reference to group N. A Group A variant-like antigen has been detected in streptococci belonging to Groups D, E, G, M, and N. In Groups D and N the variant-like antigen was located in the streptococcal cell walls. In two strains of Group N streptococci (C559 and B209) the cell walls were chemically different and serologically distinct. In strain C559 N-acetylgalactosamine, and in strain B209, N-acetylglucosamine were the major determinants of serological specificity. The cell walls of strain C559 contained at least three serologically reactive components: a rhamnose-containing fraction that precipitated with an antiserum to Group A-variant carbohydrate; a strain-specific polysaccharide composed of galactosamine and glucosamine, both in the N-acetylated form and probably polymerized with an unidentified phosphorylated substance; and a component of unknown composition serologically related to a Group D streptococcus strain C3 (S. durans). An analogy is drawn between the cell wall structure in streptococcus and Salmonella.


Macrophage-digested antigen as inducer of delayed hypersensitivity. Sheep erythrocytes ingested by guinea pig peritoneal macrophages in vitro, and permitted to undergo digestion for various periods, were found after some hours to lose the capacity to induce antibodies while gaining the ability to invoke delayed hypersensitivity. These observations may be related to the known predilection of small molecular immunogens to act as good inducers of delayed reactivity and poor stimulators of antibody. They may be related also to the activity of mycobacterial adjuvant as a vehicle for the induction of delayed hypersensitivity on the basis that this melange activates macrophages to phagocytose and enzymatically degrade macromolecular antigens rapidly. The thesis that small fragments of antigenic molecules may preferentially invoke hypersensitivity can be interpreted on the basis of current concepts of multicellular involvements in immune responses.


Pathogenesis of H-1 virus infection of embryonic hamster bone in organ culture. H-1 virus infection of hamsters has been shown to produce runting, microcephaly, cranial lacunae, and deformed teeth in animals inoculated during the suckling period and to cause various abnormalities, including skeletal defects, in embryos infected transplacentally. To explore the pathogenesis of these effects of viral infection on bone, the response of embryonic hamster tibiae in organ culture to inoculation with the H-1 strain of picodna virus was studied. This system made possible the direct observation of the reaction of bone to virus in a regulated environment. During a period of 7-17 days after inoculation the following observations were made: (a) H-1 virus was found to infect and replicate in bone. (b) Infected bones became more translucent, slender, and elongated than control bones. (c) Bone growth as measured by increase in wet weight was reduced in infected tibiae. (d) Infected bones showed periosteal and perichondral degeneration and diminished deposits of subperiosteal bone. It was concluded that the skeletal abnormalities which develop in embryonic and suckling hamsters after H-1 virus inoculation are the direct result of viral replication in bone, and that indirect phenomena such as those associated with chronic infection need not be postulated to explain the deformities seen in these animals.


Mechanisms underlying binding of immune complexes to macrophages. The mechanism of binding of immune complexes to macrophages was investigated using purified antibody and haptens of different valences. Antibody alone bound to macrophages; enhancement of binding occurred when polyvalent and divalent haptens were present at equivalence but did not occur in great antigen excess. Monovalent hapten did not increase the binding of antibody at any concentration ratio tried, though it inhibited the enhancement due to oligovalent hapten. Ultracentrifuged normal rabbit globulin also inhibited the binding of complexes indicating the presence of exposed binding sites on the uncomplexed molecules. Complexes bound more strongly than antibody alone as determined from elution studies. These results support the hypothesis that the enhancement of antibody binding to macrophages in the presence of antigen is due to increased energy of binding resulting from summation of individual binding sites already exposed on the antibody molecules. It was also possible, by saturating the macrophages with gamma globulin, to estimate the number of binding sites per cell; this was calculated to be approximately 2 million per alveolar macrophage.


Acute pericarditis--an outbreak due to Coxsackie viruses B.


Adenovirus-induced chromosome aberrations in human cells.


Factors influencing pulmonary methane excretion in man. An indirect method of studying the in situ metabolism of the methane-producing colonic bacteria. Measurements of pulmonary excretion of methane (CH(4)) were used to obtain information on the CH(4)-producing bacteria in man. Preliminary studies indicated that (a) all CH(4) excreted by man is produced by colonic bacteria, (b) there is no appreciable utilization of CH(4) by man, and (c) breath CH(4) can serve as a relatively accurate indicator of CH(4) production in the intestine. The rate of pulmonary CH(4) excretion varied enormously, ranging from undetectable (<5 x 10(-6) ml/min) to 0.66 ml/minute. In general, the CH(4) excretion rate for subjects was consistently very low (nonproducers) or relatively large (producers). 33.6% of the adult population were producers of CH(4). Whereas diet, age over 10 yr, and sex did not influence the rate of CH(4) production, some familial factor appeared to play an important role. 84% of siblings of CH(4) producers also were producers, while only 18% of the siblings of nonproducers were found to be CH(4) producers. This familial tendency appeared to be determined by early environmental rather than genetic factors. These studies of CH(4) excretion demonstrate that the exposure of individuals to intestinal bacterial metabolites may differ markedly and that these differences may be chronic and determined by familial factors.


Treatment of hepatic coma. Treatment of acute hepatic coma with plasmaphoresis and plasma exchange.


Congenital lung cysts. Segmental lung cysts: a form of congenital bronchiectasis.


Drug interactions.

Drug interactions.


Educational needs for better health care delivery in Kansas.


The feenix.

The feenix.


The pharmacology of batrachotoxin. 3. Effect on the heart Purkinje fibers.


Role of the sugar transport system in the positive inotropic response to digitalis.


The renal effects of Su-15049 on sodium reabsorption and potassium transport in the dog.


Methyltransferase enzymes in red blood cells.


Effect of phenoxybenzamine and combined administration of iproniazid and tropolone on catecholamine release elicited by renal sympathetic nerve stimulation.


Species differences in aortic responses to vasoactive amines: the effects of compound 48-80, cocaine, reserpine and 6-hydroxydopamine.


Reserpine and acetazolamide in maximum electroshock seizure in the rat.


A simple procedure for calculating the synthesis rate of norepinephrine, dopamine and serotonin in rat brain.


Facilitation and impairment of avoidance responding by phenobarbital sodium, chlordiazepoxide and diazepam--the role of performance base lines.


Studies on the increased biliary flow produced by phenobarbital in rats.


Carboxylesterase inhibition as an indicator of malathion potentiation in mice.


The effect of spironolactone on drug metabolism by hepatic microsomes.


Morphology of the eyespot and description of two pigment granules in the esophageal muscle of a marine nematode, Oncolaimus vesicarius.


Kinetic differences in the microsomal metabolism of the isomers of hexobarbital.


The substructure of the cellulose microfibrils from the cell walls of the algae Valonia ventricosa.


Structure and formation of pores in fenestrated capillaries.


A cytological analysis of artificial parthenogenesis in the surf clam Spisula solidissima.


Quality considerations in successive water use.


Effect of selected factors on pesticide sorption and desorption in the aquatic system.


Applying modern management techniques to a water pollution control program, New York City.


Periodic health checkups: how often? How thorough? How much lab work?


Headache: anatomy and analysis of a common cause.


Office treatment of childhood hip conditions. I.


How to treat cardiac arrest following acute myocardial infarction.


What's new in ophthalmology.

What's new in ophthalmology.


How I treat chronic inflammatory bowel disease.


From a malpractice lawyer's case book.

From a malpractice lawyer's case book.


The problem of viability estimates in tests for reverse mutations.


The isolation and genetic classification of UV-sensitive mutants of Schizosaccharomyces pombe.


Characterization of spontaneous mutations of mitotic and meiotic origin in the ad-I locus of Schizosaccharomyces pombe.


Reversion of an amber mutant by mutagenic DNA polymerase of bacteriophage Tr.


Chemically induced dominant-lethal mutations and cell killing mouse oocytes in the advanced stages of follicular development.


Cerebral lipids in amaurotic idiocy.

Cerebral lipids in amaurotic idiocy.


The problem of coexistence of neuronal lipid storage diseases and various forms of leucocystrophies.


Effect of potassium on glucose metabolism of guinea pig and rat brain slices in vitro.


Food allergy in ear, nose, and throat disease.


Mold allergy affecting the ears, nose and throat.


Skin titration: testing and treatment.

Skin titration: testing and treatment.


Cytotoxic reactions in the diagnosis of food allergy.


Allergic tubotympanitis.

Allergic tubotympanitis.


Allergic phenomena in the inner ear.

Allergic phenomena in the inner ear.


Allergic rhinitis and sinusitis.

Allergic rhinitis and sinusitis.


Allergy of the larynx.

Allergy of the larynx.


Treatment of allergic emergencies.

Treatment of allergic emergencies.


An unusual strain of Trichophyton rubrum from Fiji.


A comparative study of ribonucleic acid species in yeast-like and mycelial forms of Paracoccidioides brasiliensis.


The consistent formation of chlamydospores by Candida tropicalis.


Fungal cultures from skin strippings.

Fungal cultures from skin strippings.


Effect of drying on Paracoccidioides brasiliensis.


Deficient resistance to Coccidioides immitis following intravenous vaccination. I. Distribution of spherules after intravenous and intramuscular doses.


Deficient resistance to Coccidioides immitis following intravenous vaccination. 3. Humoral and cellular responses to intravenous and intramuscular doses.


Dental caries: prospects for prevention. Combined utilization of measures now available or imminent could reduce caries of the crowns of the teeth to the point of negligibility as a public health problem, if public desire were great enough to motivate changes in some of our habits (64). Universal optimum application of fluoride and substitution of starchy foods for sugary ones (or even simply judicious consumption of sugar) would alone do most of the job. Sealing of susceptible occlusal areas with adhesive polymers promises to protect the sites where fluoride evidently cannot be maximally effective. It seems unlikely that any single measure will be found sufficient to control this multifactorial disease. Consequently, we must continue the search for new means to increase the caries resistance of teeth, to reduce the cariogenicity of foodstuffs, and to check the deleterious activities of cariogenic bacteria. Anticaries food additives and antibacterial agents for intraoral use seem to be approaching practicability. Past performance warrants expectation that ongoing fundamental investigations will produce leads for future development and application.


Perception of changes in certain exteroceptive stimuli. Although cybernetic models of one sort or another have become quite common in behavioral research, and although these models theoretically require a capacity for system detection of changes in error, no general psychophysical description of the individual human being's ability to discriminate different rates of stimulation is available. An initial survey of this type has been attempted and is reported here. For reasons which appear to be related to the biological mechanisms underlying sensory information processing, it is concluded, first, that ancillary cues of rate-related final magnitude are more valuable than cues of stimulus duration; second, that direct attention to on-going change is less precise than attention to final values only; and third, that differences in isochronal stimulus rates occurring in place or extent are more readily perceived than differences in isochronal rate of change in energy content, at least for the stimuli and ranges examined.


Temporal synergism of corticosterone and prolactin controlling gonadal growth in sparrows. Gonadal growth was controlled in two avian species by corticosterone and prolactin injected daily at various times. Testicular growth was induced in photorefractory house sparrows (Passer domesticus) kept in continuous light by prolactin injected 4 or 8 hours after administration of corticosterone. Other temporal patterns were ineffective. Gonadal growth was also stimulated in photosensitive white-throated sparrows (Zonotrichia albicollis) kept in continuous light by prolactin injected 12 hours after administration of corticosterone. Daily injections of prolactin 8 hours after injection of corticosterone inhibited gonadal growth. The seasonal cycle of reproductive photorefractoriness and photosensitivity is controlled by a changing relation between the daily rhythms of plasma concentrations of corticosterone and prolactin.


Thyroxine: convesion to triiodothyronine by isolated perfused rat heart. Thyroxine labeled with carbon-14 and iodine-125 was perfused through surviving rat hearts. Only when unlabeled triiodothyronine was added as a carrier could the newly formed doubly labeled triiodothyronine be isolated. The fact that this triiodothyronine was labeled with the correct ratio of carbon-14 to iodine-125 indicated that it originated from thyroxine. Approximately 5 percent of the initial carbon-14 radioactivity was found in the recovered triiodothyronine.


Linkage of genes controlling the rate of synthesis and structure of aminolevulinate dehydratase. The rate of synthesis of delta-aminolevulinate dehydratase in mice is controlled by alleles at the levulinate (Lv) locus. Two structural mutations modifying the sensitivity of delta-aminolevulinate dehydratase to heat have been identified. Genetic analyses established that the structural locus for delta-aminolevulinate dehydratase was either physically close to or identical with the locus that controls its rate of synthesis.


Auditory evoked potentials during speech perception. Neural responses evoked by the same binaural speech signal were recorded from ten right-handed subjects during two auditory identification tasks. One task required analysis of acoustic parameters important for making a linguistic distinction, while the other task required analysis of an acoustic parameter which provides no linguistic information at the phoneme level. In the time interval between stimulus onset and the subjects' identification responses, evoked potentials from the two tasks were significantly different over the left hemisphere but identical over the right hemisphere. These results indicate that different neural events occur in the left hemisphere during analysis of linguistic versus nonlinguistic parameters of the same acoustic signal.


Factors influencing stroke rehabilitation.


Fatal foam cell arteritis of the brain after irradiation for Hodgkin's disease: angiography and pathology.


Physiological modification of immediate ischemia due to experimental middle cerebral occlusion--its relevance to cerebral infarction.


The relation between cerebral oxygen consumption and cerebral vascular reactivity to carbon dioxide.


Strokes in the young.

Strokes in the young.


Reactivity of cerebral blood flow to CO 2  in patients with transient cerebral ischemic attacks.


An assessment of early platelet activity in experimental subarachnoid hemorrhage and middle cerebral artery thrombosis in the cat.


Fisk factors in stroke due to cerebral infarction. A statement for physicians.


Contribution to the hemodynamics of arterial venous malformations.


Neurogenic control of cerebral circulation.


The moving embolus seed during serial cerebral angiography.


The comparative analysis of isotope clearance curves in normal and ischemic brain.


Basic proteins of brain ribosomes.

Basic proteins of brain ribosomes.


Interaction of lupin isoleucine-tRNA synthetase with isoleucine transfer ribonucleic acid measured by the thermal inactivation method.


The influence of basic proteins on polysomes. Studies on the reactivation of polysomes inhibited by histones in a cell-free system.


Activation of ribosomes from pea seeds by trypsin.


Intimal fibroplasia of the internal carotid arteries.


A-mode echoencephalography in the evaluation of cerebrovascular disease.


Occlusio supra occlusionem: intracranial occlusions following carotid thrombosis as diagnosed by cerebral angiography.


Responses of surface arteries and blood flow of ischemic and nonischemic cerebral cortex to aminophylline, ergotamine tartrate, and acetazolamide.


Effects of freezing on major arteries.

Effects of freezing on major arteries.


Metabolism of glucose in the sublingual gland of the rat, and the effect of insulin in vitro.


Cytosine and cytidine analogues: synthesis and properties of 5-ethylcytosine, 5-ethylcytidine and a number of their derivatives.


Effect of alloxan-diabetes on the content of sialic acids and activity of uridylyltransferases in rat salivary glands.


Elliptical petrous tomography in congenital deafness in Nigerian children.


Motor nerve conduction in kwashiorkor (protein-calorie deficiency) before and after treatment.


Haemoglobinuria in Nigerian children.

Haemoglobinuria in Nigerian children.


Biochemical distinction between ante-mortem and post-mortem skin wounds by isoelectric focusing in polyacrylamide gel. I. Experimental investigation on arylaminopeptidases.


Acute febrile encephalopathy in Ugandan children.


Febrile convulsions in Ibadan children.

Febrile convulsions in Ibadan children.


Perinatal mortality in Ibadan.

Perinatal mortality in Ibadan.


Measles infection following immunization: a report on forty-nine cases in Lagos, NIgeria.


Editorial.

Editorial.


Anorectal anomalies in neonates. (Surgical experience with twenty cases in Ibadan).


Mass measles control in West and Central Africa. Further attenuated measles vaccine has been given to 13 million children in 19 West and Central African countries as part of a regional program of smallpox eradication and measles control.  Measles transmission has been significantly reduced in most countries and interrupted only in Gambia.  Analysis of measles cases in the post-campaign period has identified measles in nonparticipants in the mass campaign, new susceptibles, and in a small number of vaccines.  Although the original program envisioned recycling, the immunization of new susceptibles, every 2-3 years, epidemiological investigation has indicated that the frequency of recycling must be increased to achieve effective control.  The current development of maintenance programs is directed at maximum utilization of mobile teams and static health facilities to achieve immunization of new susceptibles every 6 months in high density population areas and every 12-18 months in low density areas.  (author's)


Evaluation programmed learning materials.


Symposium on Research and Utilization of Educational Media for Teaching the Deaf. Programmed learning for the deaf student. Foreword.


The new economics and the deaf.

The new economics and the deaf.


The role of computer assisted instruction at the National Technical Institute for the Deaf.


New directions in programmed learning.

New directions in programmed learning.


Programmed instruction for young deaf children.


A graduate course in educational technology.


Computer assisted instruction for deaf students.


The play milieu. A preliminary appraisal.


Treatment of reactive hypoglycemia with sulfonylureas.


The importance of creative play.

The importance of creative play.


Reduced myocardial fibrosis after dimethylsulfoxide (DMSO) treatment of isoproterenol-induced myocardial necrosis in rats.


Occupational behavior. A perspective on work and play.


Vocational theories and work habits related to childhood development.


Antecedents of work behavior.

Antecedents of work behavior.


Consideration of work as therapy in the rehabilitation process.


Perceptual-motor attributes of mental retardates.


Standards and guidelines for an occupational therapy affiliation program.


Changing concepts of work.

Changing concepts of work.


CT1341: some effects in man. Cardiorespiratory, electroencephalographic and biochemical measurements.


Electroencephalographic and electrocardiographic effects of propanidid in man.


Amnesia studies with intravenous premedication.


Post suxamethonium pains and vitamin C.

Post suxamethonium pains and vitamin C.


Extradural analgesia. A controlled trial of plain solutions of bupivacaine and lignocaine.


Anaesthesia in pigs. Intramuscular ketamine as an induction agent.


An extradural analgesia service in obstetrics.


The influence of premedication with diazepam on the blood sugar level.


Methoxyflurane analgesia by Cyprane inhaler.


Regional blockade with bupivacaine (Marcain) for the insertion of Scribner shunts.


Pulmonary failure following surgery of trauma.


Lumbar extradural analgesia.

Lumbar extradural analgesia.


A method of assessing arterial blood gas tensions, inspired oxygen therapy and shunts.


Propanidid and blind nasal intubation.

Propanidid and blind nasal intubation.


A survey of respiratory problems encountered in the immediate post-operative period.


Intra-arterial pressure measurements. A review and analysis of the methods relevant to anaesthesia and intensive care.


A comparison of CT1341 with methohexitone.


A review of 41 cases of myasthenia gravis subjected to thymectomy.


Anaphylaxis under anaesthesia.

Anaphylaxis under anaesthesia.


Cold curing acrylic bone cement.

Cold curing acrylic bone cement.


Sequential observations on pulmonary functional derangements in Bagassosis.


Effect of azathioprine on renal histology and function in lupus nephritis.


Allergic bronchopulmonary aspergillosis. Report of two cases and evaluation of tests for hypersensitivity.


Successful defense against Histoplasma capsulatum in hypogammaglobulinemia.


Earth day histoplasmosis. A new type of urban pollution.


Psychosis in vitamin B 12  deficiency.

Psychosis in vitamin B 12  deficiency.


Postmeningitic selective hypopituitarism with suprasellar calcification.


Pasteurella pseudotuberculosis. Acute sepsis with survival.


Chronic lesions of the vertebral column and joints in older mice. Induction by an active agent from rheumatoid synovial tissue.


The mode of action of antibiotics on gram-negative bacilli.


Premature A-V junctional contractions.

Premature A-V junctional contractions.


Transmission of an active agent from rheumatoid arthritis synovial tissue to chicks.


Societal health and medical services.

Societal health and medical services.


Treatment of Candida infection.

Treatment of Candida infection.


An intracranial pressure transducer.

An intracranial pressure transducer.


Cardiac pacemaker encapsulation investigation.


A body balance to measure sweat rates in man.


Cutaneous angiitis. Patterns of rashes explained by (1) flow properties of blood; (2) anatomical disposition of vessels.


Clinical and epidemiological aspects of the dermal Tumbu-fly-myiasis in Equatorial-Africa.


An aid to the preoperative assessment of pigmented lesions of the skin.


Iodine-test as an aid for clinical diagnosis of basal cell carcinoma.


Alopecia areata hairs: a scanning electron microscope study.


Sebaceous gland secretion in cirrhosis.

Sebaceous gland secretion in cirrhosis.


Cutaneous reactions produced by fumaronitrile in human subjects.


A comparison of intra-lesional triamcinolone hexacetonide and triamcinolone acetonide in alopecia areata.


Successful treatment of generalized pustular psoriasis (von Zumbusch) by systemic antibiotics controlled by blood culture.


Light sensitivity and secondary plane xanthoma.


Acquired axillary and inguinal pigmentation: an epidermal naevoid abnormality not to be confused with acanthosis nigricans.


Malignant atrophic papulosis (Degos' syndrome).


Localized primary cutaneous amyloid (tumefactive type).


Macular amyloidosis.

Macular amyloidosis.


Lymphocyte transformation.

Lymphocyte transformation.


Disorders of neutrophil and monocyte function.


Hageman factor activation in the generalized Shwartzman reaction induced by endotoxin.


Nitrogen metabolism in pernicious anaemia.


Automated platelet counting.

Automated platelet counting.


Secondary polycythaemia due to a uterine fibromyoma producing erythropoietin.


A simple routine radioisotope method for the estimation of serum vitamin B12 using DEAE cellulose and human serum binding agent.


Some research implications of the Seebohm report.


Haemoglobin, vitamin B12 and folate levels in the elderly.


Before involvement--some questions for the attention of medical sociologists.


The prognosis of carotid transient ischaemic attacks in patients with normal angiograms.


An electron microscope study of Langat virus in tissue culture of the non-neuronal cells of mouse brain.


An electron microscopic study of Langat virus encephalitis in mice.


Simple reaction times of ipsilateral and contralateral hand to lateralized visual stimuli.


Opposite superiorities of the right and left cerebral hemispheres in discriminative reaction time to physiognomical and alphabetical material.


The performance of brain-damaged patients in spatial localization of visual and tactile stimuli.


The reflex response to sinusoidal stretching in spastic man.


Partial disconnexion syndrome in an ambidextrous patient.


Studies in cervical spondylotic myelopathy. I. Movement of the cervical roots, dura and cord, and their relation to the course of the extrathecal roots.


Studies in cervical spondylotic myelopathy. II. The movement and contour of the spine in relation to the neural complications of cervical spondylosis.


Studies in cervical spondylotic myelopathy. 3. Some functional effects of operations for cervical spondylotic myelopathy.


The development of the chick optic tectum. I. Normal morphology and cytoarchitectonic development.


The development of the chick optic tectum. II. Autoradiographic studies.


Ultrastructural characteristics of the caudal and rostral brain stem reticular formation.


Observations on the morphology of mammalian synaptosomes following their incubation and electrical stimulation.


Visual cortex efference to nonprimary cortex in the cat.


Electrophysiological correlates of selective attention: modality specific changes in thalamocortical evoked potentials.


Inositol production by the brain in normal and alloxan-diabetic dogs.


Survival of large cells in the dorsal lateral geniculate laminae after interruption of retinogeniculate afferents.


Rubral fibers to the facial nucleus in the rabbit.


Occurrence of heteronymous monosynaptic reflexes following tenotomy.


Specific membrane resistivity of dye-injected cat motoneurons.


Orbitofrontal modulation of EEG spindles.


Studies on pyramidal-evoked activity during the sleep-wakefulness cycle.


Electrical stimulation of the tectum in freely moving cats.


The response of auditory cortex neurons in cat to various parameters of acoustical stimulation.


Effect of picrotoxin on two-tone inhibition of auditory neurons in the cochlear necleus.


Sebaceous lymphadenoma of the parotid gland.


A comparative ultrastuctural study of leiomyosarcoma, cellular leiomyoma, and leiomyoma of the uterus.


Multiple congenital mesenchymal tumors. Multiple vascular leiomyomas in several organs of a newborn.


Ovarian adenocarcinoma of mesonephric type.


Clinical trials with adriamycin.

Clinical trials with adriamycin.


Toward the control of cancer.

Toward the control of cancer.


Treatment of metastatic colorectal carcinoma with 5-fluorouracil by mouth.


5-fluorouracil given once weekly: comparison of intravenous and oral administration.


Influence exerted by actinomycin D and x-rays on melanoblasts of different physiologic activity and different degrees of oxygenation.


Radiation therapy for cervical cancer: late effects on life span and on leukemia incidence.


Selective, elective, prophylactic contralateral mastectomy.


Treatment of metastatic breast cancer with a combination of adrenalectomy and 5-fluorouracil. Progress report.


Medulloblastoma. A report of 201 cases with emphasis on the relationship of histologic variants to survival.


Fine-needle aspiration biopsy in diagnosis, and classification of ovarian carcinoma.


Immunoglobulins during the course of acute leukemia in children. Effects of various clinical factors.


A familial Y-autosome translocation in man.


Human mitotic and meiotic chromosome damage following in vivo exposure to methotrexate.


Amino acid naphthylamidase isozymes in cancer cells and normal cells.


Hypoplastic left heart syndrome: an autosomal recessive disorder.


Accumulation of different congenital heart defects in one pedigree.


More about X-linked testicular feminization of the mouse as a noninducible(is)mutation of a regulatory locus: 5-alpha-androstan-3-alpha-17-beta-diol as the true inducer of kidney alcohol dehydrogenase and beta-glucuronidase.


The ENCU scoring system. A strategy for solving a class of single-locus genetic counseling problems.


Evidence for autosomal recessive inheritance of costovertebral dysplasia.


Incidence of cleft lip and palate in the offspring of cleft parents.


Glucose-6-phosphate dehydrogenase polymorphism: a valuable tool to study tumor origin.


Studies of human chromosomes by DNA-binding fluorochromes. 3. Detailed analyses of a D-D translocation chromosome--implications for genetic counselling.


Congenital chloride diarrhea, an autosomal recessive disease. Genetic study of 14 Finnish and 12 other families.


Similarity in amino acid composition between human serum lipoproteins and histocompatibility antigens on cell membranes.


Clinical genetics.

Clinical genetics.


Expression of paternal glucose phosphate isomerase-1 (Gpi-1) in preimplantation stages of mouse embryos.


"Reverse transcriptase" in higher cells.


Enzyme patterns and protein synthesis during synchronous conidiation in Neurospora crassa.


The ultrastructure of embryonic myocardial blood vessels.


Hyaluronate production and removal during corneal development in the chick.


The appearance of  -1,3-glucanohydrolase activity during the differentiation of the gut of sand dollar plutei.


DNA synthesis and differentiation in developing white adipose tissue.


A DNA-binding protein in meiotic cells of Lilium.


Effect of cerebro-cortical and collicular ablations upon the optokinetic reactions in the rabbit.


Spectral discrimination in a rabbit.

Spectral discrimination in a rabbit.


Shape discrimination in the rabbit.

Shape discrimination in the rabbit.


Locomotro activity in normal and dark-reared rabbits.


Description of a locomotor activity registration system.


Electroretinogram (ERG) and visual evoked response (VER) in rabbits reared in total darkness or continuous illumination.


The electroretinogram in normal and light-deprived rabbits.


Effect of endocrine factors on cholesterol turnover in young and old rats.


The effect of limited milk feeding on the longevity of the house fly, Musca domestica L.


Hydrolase activity and intracellular pH in liver, heart and diaphragm of aging rats.


Aging of the connective tissue: collagen cross linking in animals of different species and equal age.


Production of advanced coronary atherosclerosis, myocardial infarction and "sudden death" in swine.


Increased permeability of the arteries in hypertensive rats: an electron microscopic study.


Vitamin deficits in severe alcoholic fatty liver of man calculated from multiple reference units.


Hepatotoxicity of dimethylnitrosamine in the rat with special reference to veno-occlusive disease.


Alterations in population dynamics of arterial smooth muscle cells during atherogenesis. I. Activation of interphase cells in cholesterol-fed swine prior to gross atherosclerosis demonstrated by "postpulse-salvage labeling".


Carbon tetrachloride hepatotoxicity in female rats.


Delayed development of immune response in pituitary dwarf mice. A comparison of primary and secondary response to sheep erythrocytes.


Skin reactivity in childhood. Streptokinase-skin-test and phytohaemagglutinin-skin-test.


The pathologist and ionizing radiation.

The pathologist and ionizing radiation.


II. Growth and development.

II. Growth and development.


3. Neoplasia. Introduction and overview.


Carcinoma of the thyroid.

Carcinoma of the thyroid.


Carcinoma of the skin.

Carcinoma of the skin.


Carcinoma of the stomach.

Carcinoma of the stomach.


Carcinoma of the prostate.

Carcinoma of the prostate.


Other tumors.

Other tumors.


IV. Degenerative changes. Cardiovascular disease.


Late gonadal radiation effects.

Late gonadal radiation effects.


Aplastic anemia.

Aplastic anemia.


Central nervous system.

Central nervous system.


V. Immunopathology.

V. Immunopathology.


Protection and prevention.

Protection and prevention.


VI. Aging.

VI. Aging.


The reaction of amines with pyridoxal azomethines. The question of transaldimation and its role in the mechanism of vitamin B6 enzymes.


Insulin peptides. 18. The synthesis of a partially protected heneicosapeptide containing the C-terminal sequence of the B chain of insulin.


Insulin peptides. XIX. The synthesis of two nonapeptide derivatives related to the N terminus of the B chain of insulin from various species (positions 1-9).


Insulin peptides. XX. The synthesis of a heneicosapeptide derivative corresponding to the C-terminal sequence of the human insulin B chain.


Insulin peptides. XXII. A synthesis of the human insulin B-chain S-sulfonate.


Studies of the chymotrypsinogen family of proteins. 13. Inhibitor-induced transient change in fluorescence of alpha-chymotrypsin.


Activation analysis of trace elements in lipids with emphasis on marine oils.


Effect of heme compounds on lipid oxidation.


Copper(I) and copper(II) complexes in solution and the crystalline state.


Metal-catalyzed oxidation in the presence of water in foods.


Calcium requirement for lipoxygenase catalyzed linoleate oxidation.


Aflatoxin effects in livestock.

Aflatoxin effects in livestock.


Control and removal of aflatoxin.

Control and removal of aflatoxin.


Nutritional framework of oilseed proteins.


Microbiological assay of the beta-exotoxin of Bacillus thuringiensis.


Kinetics of action of nystatin on yeast.


Body composition, aerobic capacity, and density of muscle capillaries in young and old men.


Atrial function during volume loading.

Atrial function during volume loading.


High-frequency oscillation of blood free fatty acid levels in man.


Muscle glycogen utilization during exhaustive running.


Effects of extended hypoxia on visual performance and retinal vascular state.


Effect of water immersion on renin-aldosterone and renal sodium handling in normal man.


Body hydration and the incidence and severity of acute mountain sickness.


Energy sources during muscular work under normoxic and hypoxic conditions.


Steady-state oxygen transport through red blood cell suspensions.


Bronchial mechanics in excised dog lobes.


Bronchial closure with Mecholyl in excised dog lobes.


Availability of substrates and capacity for prolonged heavy exercise in man.


Dynamic compliance, limit cycles, and static equilibria of excised cat lung.


Hypoventilation and pulmonary hypertension in calves after carotid body excision.


Diffusion characteristics of pulmonary blood-gas barrier at low temperatures.


Effect of anemia, species, and temperature on CO kinetics with red blood cells.


Physiologic and anatomic effects of papain on the rabbit lung.


Heart rate and rectal temperature relationships during work in hot humid environments.


Effects of changes in respiratory pattern on physiological dead space.


Computation of mean body temperature from rectal and skin temperatures.


Alveolar-arterial PCO 2  differences during rebreathing in chronic airways obstruction.


Infrared-emitting diode and optic fibers for underwater force measurement in heart muscle.


Intravascular area transducer measuring dynamic local distensibility of the aorta.


The effect of ethidium bromide on mitochondrial DNA synthesis and mitochondrial DNA structure in HeLa cells. The synthesis of mitochondrial DNA (mDNA) in HeLa cells is selectively inhibited by relatively low concentrations of ethidium bromide. After exposure of cells to strongly inhibitory concentrations of the drug, the apparent superhelix density of mDNA is rapidly increased, as judged by its buoyant density in CsCl in the presence of ethidium bromide. Mitochondrial DNA synthesized in the presence of partially inhibitory concentrations of ethidium bromide is also altered in its buoyant density in the presence of the dye, but is more heterogeneous in this respect. However, the change in buoyant density of newly synthesized mDNA may be explained by changes in structure other than a change in superhelix density, as indicated by its increased resistance to digestion by pancreatic DNase.


Oxidative phosphorylation and ultrastructural transformation in mitochondria in the intact ascites tumor cell. We have examined the ultrastructure of mitochondria as it relates to energy metabolism in the intact cell. Oxidative phosphorylation was induced in ultrastructurally intact Ehrlich ascites tumor cells by rapidly generating intracellular adenosine diphosphate from endogenous adenosine triphosphate by the addition of 2-deoxyglucose. The occurrence of oxidative phosphorylation was ascertained indirectly by continuous and synchronous monitoring of respiratory rate, fluorescence of pyridine nucleotide, and 90 degrees light-scattering. Oxidative phosphorylation was confirmed by direct enzymatic analysis of intracellular adenine nucleotides and by determination of intracellular inorganic orthophosphate. Microsamples of cells rapidly fixed for electron microscopy revealed that, in addition to oxidative phosphorylation, an orthodox --> condensed ultrastructural transformation occurred in the mitochondria of all cells in less than 6 sec after the generation of adenosine diphosphate by 2-deoxyglucose. A 90 degrees light-scattering increase, which also occurs at this time, showed a t (1/2) of only 25 sec which agreed temporally with a slower orthodox --> maximally condensed mitochondrial transformation. Neither oxidative phosphorylation nor ultrastructural transformation could be initiated in mitochondria in intact cells by the intracellular generation of adenosine diphosphate in the presence of uncouplers of oxidative phosphorylation. Partial and complete inhibition of oxidative phosphorylation by oligomycin resulted in a positive relationship to partial and complete inhibition of 2-deoxyglucose-induced ultrastructural transformation in the mitochondria in these cells. The data presented reveal that an orthodox --> condensed ultrastructural transformation is linked to induced oxidative phosphorylation in mitochondria in the intact ascites tumor cell.


Microtubule protein. Identification in and transport to nerve endings. The subunit protein of microtubules, tubulin, has been demonstrated to be present in isolated nerve endings by gel electrophoresis, amino acid composition, and peptide mapping. The tubulin constitutes approximately 28% of the soluble protein of the nerve endings. The transport of tubulin to the nerve endings has been demonstrated and its relationship to slow transport is discussed.


Electron microscope histochemical evidence for a partial or total block of the tricarboxylic acid cycle in the mitochondria of presynaptic axon terminals. Respiration-linked, massive accumulation of Sr(2+) is used to reveal the coupled oxidation of pyruvate, alpha-oxoglutarate, succinate, and malate by in situ mitochondria. All of these substrates were actively oxidized in the dendritic and perikaryal mitochondria, but no alpha-oxoglutarate or succinate utilization could be demonstrated in the mitochondria of the presynaptic axon terminals. A block at an early step of alpha-oxoglutarate and succinate oxidation is proposed to account for the negative histochemical results, since the positive reaction with pyruvate and malate proves that these mitochondria possess an intact respiratory chain and energy-coupling mechanism essential for Sr(2+) accumulation. This indicates that the mitochondria in the axon terminals would be able to generate energy for synaptic function with at least some of the respiratory substrates. With regard to the block in the tricarboxylic acid cycle, the oxaloacetate necessary for citrate formation is suggested to be provided by fixation of CO(2) into some of the pyruvate.


Isolation of germ cell Golgi apparatus from seminiferous tubules of rat testes. Intact Golgi apparatus have been isolated with good purity from rat testis by a simplified sucrose gradient technique. The procedure is inherently selective in that most of the Golgi apparatus in the isolate are from germ cells in late spermatocyte or early spermatid development. No Sertoli cell Golgi apparatus are present in the fraction. Biochemical analyses showed that the enzyme N-acetylglucosamine galactosyltransferase is enhanced in the band containing Golgi apparatus. Because they are easy to isolate, and because they are involved with the formation of a specific internal cellular component (the acrosome), these Golgi apparatus will be useful objects for comparison with other kinds of Golgi apparatus and for other studies leading to a better understanding of the basic functioning of Golgi apparatus.


Ultrastructural evidence of polarized synapses in the nerve net of Hydra.


Increase in osmiophilia of axonal membranes of crayfish as a result of electrical stimulation, asphyxia, or treatment with reducing agents. Certain axonal membranes of crayfish abdominal nerve cord display ultrastructural changes if the axons are fixed, during electrical stimulation, by aldehydes followed by osmium. Such changes are characterized by an increase in electron opacity and thickness of the unit membranes' dense strata in the axon surface, endoplasmic reticulum, and outer mitochondrial membranes. The electron opacity completely disappears if the sections are treated with hydrogen peroxide solutions. This suggests that the changes represent an increase in the membranes' reactivity for osmium. An unmasking of SH groups could explain such increased osmiophilia, since SH groups are very reactive with osmium, while disulfide bonds are considerably less reactive. This hypothesis was tested by treating control, glutaraldehydefixed nerve cords with disulfide reducing agents. In these preparations an increase in electron opacity and thickness was observed to be localized in the same axonal membranes which reacted as a result of electrical stimulation. The phenomenon did not appear if the SH groups were blocked by maleimide or N-ethylmaleimide before treatment with osmium. These findings seem to suggest that certain axonal membranes of crayfish contain proteins rich in sulfur whose SH groups are unmasked as a result of electrical stimulation. In preliminary experiments an increase in osmiophilia localized in the same membranes with the same characteristics and distribution was observed also in axons from nerve cords asphyxiated either in vitro or in the living animal.


Centriole morphogenesis in developing ciliated epithelium of the mouse oviduct. The differentiating mouse oviduct has been used for the study of centriole morphogenesis because its epithelium is extensively ciliated and centriole formation occurs in a brief period after birth. Proliferative elements, consisting of an extensive fibrillar meshwork encrusted with 75 mmicro granules, were encountered at all ages, but were the only centriole precursors present in younger animals (2-3 days). These large aggregates were found either physically associated with a mature centriole or alone, but never associated with procentrioles. It is likely, therefore, that although proliferative elements may be derived from preexisting centrioles, they do not directly produce new centrioles. An intermediate structure, the condensation form, found primarily in older animals (4-6 days), and produced by the packing of the proliferative element material, gives rise to daughter procentrioles. This association of procentriole and condensation form has been called a generative complex. Condensation forms undergo various stages of depletion, producing hollow spheres with thin walls or small osmiophilic aggregates as procentrioles grow in length and assemble their microtubules. From these observations it is concluded that synthesis of microtubular precursor protein is mediated by the mature centriole and that this protein is packaged into many condensation forms in order to allow the rapid assembly of a large number of centrioles in a brief period of time.


Variable periodicity in the rhizoplast of Naegleria flagellates.


Repetitive maturation cycles in a cultured mouse myeloma.


The myofilament lattice: studies on isolated fibers. I. The constancy of the unit-cell volume with variation in sarcomere length in a lattice in which the thin-to-thick myofilament ratio is 6:1. The spacing between the thick myofilaments of muscle fibers from the walking legs of crayfish (Orconectes) was determined by optical transform analysis of electron micrograph plates of fixed single fibers and by X-ray diffraction of living single fibers. Sarcomere lengths were determined by light diffraction prior to fixation and prior to the in vivo experiments. From these combined measurements, it is demonstrated that the unit-cell volume of the myofilament lattice is constant during muscle shortening, indicating that the myofilament lattice works in a constant-volume manner. It is further demonstrated with X-ray diffraction measurements of living single fibers that the myofilament lattice continues to work at constant volume after the sarcolemma is removed from the fiber. This indicates that the constant-volume behavior of muscle is inherent to the myofilament lattice.


Impulse conduction in the shrimp medullated giant fiber with special reference to the structure of functionally excitable areas.


Urinary excretion of gentamicin in the neonatal period.


Aspergillus nidulans: association of certain alkaline phosphatase mutations with decreased virulence for mice.


Effects of thorotrast on humoral antibody, viral multiplication, and interferon during infection with St. Louis encephalitis virus in mice.


Influence of age on infection with St. Louis Encephalitis virus.


Transmission of acute infectious nonbacterial gastroenteritis to volunteers by oral administration of stool filtrates.


Ten years' experience with subdiaphragmatic abscess in a community hospital.


Primary malignant tumors of the hand.

Primary malignant tumors of the hand.


Esophageal atresia with tracheo-esophageal fistula occurring in multiple birth.


Radiation injury to the small intestine: report of one case with obstruction thirty years after treatment.


The significance of the changes in the continuous fetal heart rate in the first stage of labour.


Intensive care of the high risk fetus in labor.


Stressed cardiotocography in late pregnancy.


Nuchal encirclement by the umbilical cord.


Management and treatment of 34 cases of antepartum thromboembolism.


Changes in plasma total protein, albumin, urea and alpha-amino nitrogen concentrations in pregnancy and the puerperium.


ABO blood group in trophoblastic disease.


Energy cost and blood sugar level during different stages of labour and duration of labour in Asiatic women.


Continuous low doses of clomagestone in fertility control.


Scanning electron microscopy in the study of cervical neoplasia.


Sources of variation in menstrual blood loss.


Modified filtration-permeability model of transcapillary transport--a solution of the Pappenheimer pore puzzle?


Flow in nonuniform small blood vessels.

Flow in nonuniform small blood vessels.


Simulation studies of blood flow through stenoses in the microcirculation.


Effect of pressure, flow, and vasoactive agents on vascular resistance and capillary filtration in canine fetal, newborn, and adult lung.


Intravascular clotting induced by antigen-antibody reactions: protection by extreme thrombocytopenia.


Studies on the nutrition of the genus Pestalotiopsis. II. Chromatographic analysis of the medium during the utilization of various carbohydrates.


Effects of temperature, light, carbon and nitrogen nutrition on reproduction in phoma medicaginis.


The role of ascorbic acid in the pathogenesis and treatment of pressure sores.


Workload and energy expenditure during wheelchair propelling.


Vascular reflexes in spinal shock.

Vascular reflexes in spinal shock.


Photoelectric effects in a bimolecular lipid membrane in the presence of light sensitive inorganic ions.


Clinical investigation of bone metabolism in spinal cord lesions.


Use of mathematical and electronical models in the biomedical research.


Is "behavior therapy" behavioristic? (An analysis of Wolpe's psychotherapeutic methods).


Patella position in the normal knee joint.


Electron beam recorder. Evaluation of its use in diagnostic roentgenology.


Cerebral venous drainage pattern of the Sturge-Weber syndrome.


Localization of strontium 85 in soft tissue infected by Aspergillus niger.


The scintillation camera with pinhole collimator in thyroid imaging.


Herniography: radiologic investigation of inguinal hernia.


The valve of exploratory laparotomy in malignant lymphoma.


The significance of skull fractures in children. A study of 1,187 patients.


Blocking considerations in mantle therapy.


Radiation effect on the vascularization of a C3H mouse mammary carcinoma. Microangiographic studies of the tumor in preirradiated tissue and of the recurrent tumor.


Arteriographic assessment and staging of renal-cell carcinoma. Analysis of a series of 120 patients.


Effect of fractionation of radiation dose on callus formation at site of fracture.


RPC of the month from the AFIP.

RPC of the month from the AFIP.


"Contour maker" eliminating body casting in radiotherapy planning.


The 1971 meeting of the ICRP.

The 1971 meeting of the ICRP.


Delay in diagnosis of colonic cancer--a continuing challenge.


The bolus effect in excretory urography.


Radiographic findings in anomalous muscle bundle of the right ventricle. An analysis of 15 cases.


Magnification coronary arteriography.

Magnification coronary arteriography.


Chronic eosinophilic pneumonia.

Chronic eosinophilic pneumonia.


Spring suction device for pulmonary needle aspiration biopsy.


Subepithelial endobronchial metastases.

Subepithelial endobronchial metastases.


Fluoroscopic tracheal intubation for bronchography.


Adrenal arteriography and venography in primary aldosteronism.


The nutrient supplement-enhanced celiac angiogram.


False aneurysm associated with gastric ulcer. Report of a case.


Differentiation of acute nonspecific jejunitis from mechanical small bowel obstruction.


A safer balloon catheter assembly for colon examinations.


Roentgen findings in intestinal ganglioneuromatosis. Its association with medullary thyroid carcinoma and pheochromocytoma.


Fragmentation of the lower pole of the patella in spastic lower extremities.


Riboflavin photosensitized oxidation of 2,4-dichlorophenol: assessment of possible chlorinated dioxin formation. Dimeric products are formed by riboflavin-sensitized photooxidation of 2,4-dichlorophenol. The products of this reaction were examined to determine whether chlorinated dibenzo-p-dioxins could be formed from chlorophenols in water by the action of light of wavelengths greater than 280 nanometers. Dimers are formed by union of phenoxy radicals through carbon-carbon or carbon-oxygen bonds. 4,6-Dichloro-2-(2,4-dichlorophenoxy) phenol was obtained in greater quantity than other dimers. Products were characterized by combined gas chromatography and mass spectrometry. Chlorinated dibenzo-p-dioxins which could result from ring closure of a 2-phenoxyphenol derivative were not detected in the products of photolysis. The failure to detect chlorinated dibenzo-p-dioxins may result from the rapid photolytic breakdown of the lower chlorinated dibenzop-dioxins. Under environmental conditions, dioxins are unlikely products of the lower chlorinated phenols or phenoxyalkanoic acids.


Population and family planning programs: a factbook.


Dopamine: release from the brain in vivo by amantadine. After dopamine stores in the caudate nucleus of cats were labeled with [(3)H]dopamine, the ventricular system was perfused with artificial cerebrospinal fluid. The addition of amantadine to the perfusing fluid caused a doserelated increase in the concentrations of [(3)H]dopamine appearing in the perfusion effluent. Subthreshold concentrations of amantadine also enhanced the efflux of [(3)H]dopamine induced by electrical stimulation of the caudate nucleus.


Differences in the distribution of catecholamine varicosities in cat and rat reticular formation. The distribution of catecholamine varicosities within the brainstem reticular formation of the immature cat was determined by means of the formaldehyde-induced fluorescence technique. A continuous pattern of intense, green, medium-sized varicosities exists at nearly all brainstem levels. At most of these levels the varicosities appear within the boundaries of reticular formation nuclei. However, in rostral mesencephalon, some of the varicosities of the pattern lie in proximity to perikarya of the red nucleus. In addition, numerous varicosities in caudal medulla appear to extend from the pattern into nonreticular formation nuclei. A comparable pattern of reticular formation fluorescence is absent in the rat and this finding is believed to represent a true interspecies difference.


Freezing and melting of lipid bilayers and the mode of action of nonactin, valinomycin, and gramicidin. An abrupt loss of effectiveness of the presumed carriers, nonactin and valinomycin, in mediating ion conductance occurred at the same temperature as the membrane fluidity, judged visually, was lost. By contrast, the effects of the presumed channel-former, gramicidin, were the same on solid and liquid membranes. Taken together, these findings imply that freezing the membrane primarily reduces the mobility of these antibiotics with little effect on their solubility.


Molecular structure of starch-type polysaccharides from Hericium ramosum and Hericium coralloides. Starch isolated from the fungi Hericium ramosum and Hericium coralloides differs from that of higher plants in that it consists only of short-chain amylose molecules (32 to 45 glucose units long).


Disposition of morphine in man.

Disposition of morphine in man. The disposition of morphine was investigated by means of radioimmunoassay after a single intravenous dose (10 milligrams per 70 kilograms) was administered to 10 adult normal male subjects who had not received other drugs for 2 weeks preceding the study. A multiphasic decline in serum concentrations of morphine occurred. Detectable blood concentrations of morphine, or of a metabolite, or of both persisted for 48 hours after a single intravenous dose.


Inhibition of normal growth by chronic administration of delta-9-tetrahydrocannabinol. Body weight, food and water intake, and feces weight of 20 albino rats were recorded daily for 70 days. On days 11 to 40, 12 rats received behaviorally effective doses of Delta-9-tetrahydrocannabinol, either orally or intraperitoneally. These rats ate significantly less than placebo-dosed controls during the treatment period, and gained significantly less weight. Food intake recovered in the 30-day posttreatment period, but the former drug group still weighed less than the controls on day 70. In addition, all rats who had received intraperitoneal injections of Delta-9-tetrahydrocannabinol showed evidence of chronic diffuse nonsuppurative peritonitis.


Growth effects of vanadium in the rat.

Growth effects of vanadium in the rat. Vanadium is necessary for growing rats raised inside trace elementcontrolled, all plastic isolators on a highly purified amino acid diet. Addifion of vanadium to the diet enhances growth by over 40 percent. A nearly optimum effect is obtained with 10 micrograms of vanadium per 100 grams of diet in (0.1 part per million), supplied in the form of sodium orthovanadate, as seen from series of tests with levels ranging from 1 to 5 micrograms per 100 grams of diet. Different vanadium compounds show different potencies: sodium orthovanadate was effective, metavanadate less active, and pyrovanadate without activity. Tetravalent vanadium, supplied as vanadyl sulfate or acetate, was utilized but produced smaller responses. The amounts of vanadium required are those normally found in tissues and nutrients.


Intestinal secretion: stimulation by peptides. Two peptides isolated from intestinal mucosa, vasoactive intestinal peptide, and gastric inhibitory peptide, stimulate small intestinal secretion in conscious dogs. Glucagon and pentagastrin also stimulate, but secretin and the octapetide of cholecystokinin do not. The stimulants may participate in regulation of intestinal secretion in health and in diseases with excessive secretion.


Episodic central nervous system ischemia of undetermined cause: relation to occult left atrial myxoma.


An analysis of the effects of nicotine on the cerebral circulation of an isolated, perfused, in situ cat brain preparation.


Cerebral blood flow measurement as a safeguard during carotid endarterectomy.


Natural history of stroke in Rochester, Minnesota, 1945 through 1954.


Osteoporosis in hemiplegia.

Osteoporosis in hemiplegia.


Record linkage in studies of cerebrovascular disease in Oxford, England.


A study of blood coagulation following an acute stroke.


The electrical activity of the heart and brain under acute experimental anoxia: the protective effect of polarizing solutions.


Medicine and society. Whatever happened to homeostasis?


Vascular trauma. A review of 250 cases.

Vascular trauma. A review of 250 cases.


Primary mesenteric venous occlusive disease.


Ultrastructural studies of bile ductules in the course of acute hepatitis.


Bullet embolus to the right ventricle. Report of three cases.


Acalculous cholecystitis in burned patients.


Therapeutic trial with methylphenobarbital (Prominal), an enzyme inducer, in liver disease. A contribution to the question of hepatotoxicity of barbiturates.


A new quantitative method of assessing the functional status of the leg veins.


Ultrastructural localisation of acid and alkaline phosphatase activity in normal human liver and in the course of acute hepatitis.


Breast carcinoma presenting as an axillary mass.


Hernia of the foramen of Bochdalek in the adult.


Pathophysiologic role of hypocarbia in post-traumatic pulmonary insufficiency.


Effects of experimental recurrent microembolization on pulmonary function and distribution of labeled macroaggregates of sulfur.


Changes in intracellular sodium and potassium content of red blood cells in trauma and shock.


Aspartic acid in the treatment of chronic hepatitis.


What constitutes the proper solution for resuscitation of the severely burned patient?


How frequently is a palpable liver to be found during systematic examination of an apparently healthy population?


Effects of operative manipulation on the flow of intestinal lymphatics.


Incidence of the Leriche syndrome in patients with Subclavian Steal.


Seat belt trauma of the colon.

Seat belt trauma of the colon.


Prevention of stress ulcers.

Prevention of stress ulcers.


Postoperative recovery of flexor tendon function.


Abdominal tap: indication, technic, and results.


Mediastinoscopy using local anesthesia.

Mediastinoscopy using local anesthesia.


Inguinal hernia repair using the rectus-pyramidalis sheath.


Interesting and unusual lesions encountered during mediastinoscopy.


Ultraconservative management of superficially invasive epidermoid carcinoma of the true vocal cord.


Bronchoesophagologic application of recent advances in fluoroscopy.


Esophageal dysfunction and other swallowing difficulties in early life.


Thyroid function after radiotherapy and total larynbecômy in the treatment of carcinoma of the larynx.


Forward and backward sweep responses in Békèsy audiometry.


Conditions and course of accumulation and excretion of amylases in cultures of Aspergillus oryzae.


Blood levels of vasotocin in birds.

Blood levels of vasotocin in birds.


Effect of heparin on the distribution of the transplanted lymphoid cells in recipient organs.


Static mechanical properties of the lung in "bronchitic" and "emphysematous" obstructive lung disease.


Correlation of morphological and histomechanical data in normal and diseased lungs.


Changing perspectives on professionalism, or what's in a name?


Frequency dependence of pulmonary compliance and resistance in patients with mild and severe chronic obstructive lung disease.


Mechanical effects of the compressibility of alveolar gas in patients with chronic obstructive lung disease.


Radiopertechnetate renography with the gamma ray scintillation camera. Radiopertechnetate renography merits consideration as another intravenous screening procedure for renovascular hypertension. Thus far in our experience it has yielded fewer falsely negative results than the radiohippurate renogram, and it takes less than one minute to complete. Applications of this method to the assessment of renal perfusion in other renal afflictions are described. The examination requires a stationary imaging device interfaced with a storage device and a data processor. It has the advantage of providing a comparison of renal transit of the test agent with its transit through the systemic circulation, e.g. the aorta.


Ethanol metabolism in various racial groups. Eskimos and Indians, according to casual reports, take longer to sober up after an alcoholic debauch than do whites. We studied this apparent difference by administering ethanol to appropriate subjects and determining blood alcohol concentrations at intervals. We found the concentrations fell significantly faster in whites. Neither previous experience of alcohol nor general diet appeared to account for this difference, leaving genetic factors as the indicated cause.


Dermatophyphics in childhood leukemia.

Dermatophyphics in childhood leukemia. The dermatoglyphics of 54 leukemic children do not differ significantly from those of 25 mothers and 592 unrelated controls with respect to frequency of digital pattern types, position of axial triradius, or type of palmar flexion creases. These findings do not support the hypothesis that children with leukemia have an increased frequency of unusual dermal patterns, but suggest that the dermatoglyphics of leukemic children are not distinctive and therefore have no practical value in the diagnosis of childhood leukemia. Whatever factors are responsible for the development of leukemia in children, these factors do not appear regularly to affect the differentiation of the dermal ridges.


Factors contributing to airflow obstruction in patients with chronic bronchitis and emphysema.


The airway as a Starling resistor.

The airway as a Starling resistor.


Experiences with a sac-type artificial heart. A total replacement artificial heart is described having in vitro performance satisfying human requirements up to and including moderate work.The in vitro design has been modified to make its implantation into the chests of experimental animals technically feasible.The heart has been tested in vivo for up to six hours, and has been found to provide the experimental animals with adequate blood flow and pressures.Preliminary tests have shown major problems of air embolism and red blood cell hemolysis.The heart design and technique of implantation are undergoing further improvement. Performance will be more comprehensively examined with the use of larger experimental animals in order more accurately to evaluate the heart's potential.


Dynamics of gas and work of breathing in obstructive lung disease.


Survivorship: the estimation and interpretation of survival experience.


Day surgery for children.

Day surgery for children.


Leiomyoma of the uterus with bilateral pulmonary metastases.


Phase differences between gas displacement by the thorax and at the airway opening.


Paroxysmal torticollis in infancy.

Paroxysmal torticollis in infancy.


Krabbe's globoid cell leukodystrophy. Galactocerebroside  -galactosidase deficiency: a multidisciplinary approach to the study of patients with progressive neurological disease.


Multiple trauma (case P47).

Multiple trauma (case P47).


Distribution of constitutive heterochromatin in mamallian chromosomes.


Polymorphic patterns of heterochromatin distribution in guinea pig chromosomes.


Genetic and environmental components of chiasma control. I. Spatial and temporal variation in Schistocerca and Stethophyma.


The cytogenetic systems of grasshoppers and locusts. I. Chortoicetes terminifera.


--chromosome inheritance and the porblem of chromosome "imprinting" in Sciara (Sciaridae, Diptera).


The bereavement of the widowed.

The bereavement of the widowed.


Psychoactive drugs: a usage guide.

Psychoactive drugs: a usage guide.


Labyrinthine versus central nystagmus: electronystagmographic observation.


Role of iatrogenesis in diagnosis, prognosis and treatmet in psychiatry.


Motor impairment in chronic alcoholics.

Motor impairment in chronic alcoholics.


Clinical neuropathological conference.

Clinical neuropathological conference.


Treatment of acute myocardial infarction by transmural blood supply from the ventricular cavity.


Experimental investigations in ventricular fibrillation under hypothermy.


Mode of action of protamine in regard to its circulatory and respiratory side effects.


Synchronous and synchronized culture of Saccharomyces cerevisiae with respect to relative age of individual cells.


Growth and physiology of a yeast cultivated in batch and continuous culture systems.


The occurrence of geometrical isomers of lycopene in the modification of the UV-induced mutant of Mycobacterium phlei.


Alanine and lysine synthesis by Ustilago maydis.


Antimicrobial agents. IX. Effect of steroids on dermatophytes.


Some biological and ecological aspects of the rhizosphere effect.


Further data on the polarity of the pabai locus of Aspergillus nidulans.


X-Y exchanges in males of Drosophila hydei carrying the wmCo duplication.


The action of the Notch locus in Drosophila hydei.


Cat gene frequencies in Richmond, California.


Competitive fitness in experimental populations of Drosophila willistoni.


An ultrastructural study of the effect of neomycin on the colon in the human subject and in the conventional and the germ-free mouse. An electron microscopic study of the colon of normal mice and human subjects and those treated with neomycin is reported; there is a close resemblance between the mouse and human colons. After rapid disinfection of the colon, there is epithelial cell damage due to a toxic effect of the drug, a reduction in epithelial turnover accompanying the change in flora, and an important reduction in the cellularity of the lamina propria mainly due to a reduction in inflammatory cells. The changes in the lamina propria probably represent changes in the antipathogenetic defences of the host.


Movement of segmental constrictions in the human colon. Changes in the segmental pattern of opaque contents in the transverse colon among patients with diverticulosis were observed by means of time-lapse cinefluorography after ingestion of barium sulphate suspension. In some of them the muscular constrictions separating the opaque masses of bowel contents were seen to relax and later to re-form in a different spatial relationship to fixed points on the bowel wall represented by the necks of diverticula. In other instances ring contractions moved progressively along the bowel wall, temporarily occluding the necks of any diverticula they passed. Bowel contents were seen to be transported ahead of the advancing constrictions at varying rates and in either direction.


Disappearance of gastrin and pentagastrin in the portal circulation. Experiments on dogs and rats showed that synthetic human gastrin I was inactivated in the small bowel but not in the liver, whereas pentagastrin was rapidly inactivated by the liver. Similar results were obtained with tissue homogenates. The significance of these results is discussed in relation to the probably increased incidence of peptic ulceration following extensive small-bowel resection in man.


Experimental hepatic cirrhosis in dogs caused by chronic massive iron overload. Starting in October 1966, 19 dogs have been subjected to massive parenteral iron loading using intravenous iron-dextran and intramuscular iron-sorbitol. Although 13 animals died, in many cases the deaths were attributable to fighting. The large doses of iron employed (up to 5.8 g/kg) were well tolerated by the surviving animals, and after 35 to 47 months five of the six survivors have developed hepatic cirrhosis with massive siderosis; the dog which has not yet developed cirrhosis received the smallest iron load. The liver pathology in many ways resembles that of human haemochromatosis, and may provide an experimental model for the study of chronic iron-induced liver injury.


Absorption of sodium and water by human rectum measured by a dialysis method. A dialysis method for the study of intestinal absorption is described. Its use has been assessed in animals and normal human subjects and it has been applied to the measurement of rectal transport of sodium and water.When the luminal solution was of high sodium concentration (145 m-equiv/1), the sodium influx rate (lumen to plasma) was about five times greater than the sodium efflux rate (plasma to lumen). The luminal sodium concentration associated with zero net sodium flux was very low (<15 m-equiv/1). As the mucosa was charged with the luminal side negative, the epithelium must therefore possess a powerful sodium absorbing ;pump'. With isotonic solutions in the lumen, the amount of water absorbed depended on the sodium concentration and when this was 30 m-equiv/1 or less, no significant water absorption was detectable. When, however, water absorption was altered by imposing osmotic gradients, sodium absorption was not significantly affected. The luminal solution tended to become issomolar with plasma; osmotic gradients across the epithelium did not develop. The particular transport properties of rectal epithelium enabling it to remove sodium from the lumen against considerable electrochemical gradients are well adapted to its function.


The value of phenol red and chromic chloride as nonabsorbable gastric indicators. A comparison is made of gastric loss of phenol red and chromic chloride other than by emptying. Chromic chloride appears to be lost by adsorption on to mucus to a considerably greater extent than does phenol red, suggesting that chromic chloride is less satisfactory as a nonabsorbable gastric indicator.


A paediatric tube and capsule for suction biopsy of the small intestinal mucosa designed for direct nasogastric intubation. The use of a modified paediatric tube and capsule for suction biopsy of the mucosa of the small intestine is discussed. The tube is small in diameter and can be introduced through the nose without local trauma and with minimal discomfort. The intubation technique was followed in 72 instances to obtain suction biopsies from the proximal mucosa of the small intestine in protein-calorie malnourished children, and the results obtained with this instrument are also presented.


Neutron dosimetry with nuclear track detectors applied to in vivo neutron activation analysis.


A portable low-energy photon calibration source.


Radiological protection in the Central Electricity Generating Board.


Experience in the control of radiation dose in United Kingdom civil nuclear power stations.


Difficulties in measuring the maximum permissible levels of surface contamination for radionuclides that decay primarily by electron capture.


On 134Cs in rainwater from 1960 to 1969.


Transfer of radiocesium from lichen to reindeer.


239Pu(IV): its subcellular distribution and association with ferritin in the canine liver.


Sex differences in Cs metabolism in man.


Dietary intakes of iodine and thyroid dosimetry.


Contamination of a university print shop resulting from the cleaning of a static eliminator device.


Metrology in health physics and the ICRU.


Lymphocyte function in the aged.

Lymphocyte function in the aged.


Early effects of parathyroid hormone on tubular calcium and magnesium reabsorption.


The chaplain and the dying patient.

The chaplain and the dying patient.


The influence of dimethyl-biguanide on the postprandial syndrome after gastrectomy with special reference to glucose tolerance test and insulin production.


Leadership: some behaviors and attitudes of hospital supervisors.


A new era of day care programs for the elderly.


Participative management: a technique for employe motivation.


CHSLP: expectations and realizable goals.


Corporate changes in Catholic hospitals.


Techniques of purchasing negotiation for hospital buyers.


Canonical implications of mergers, affiliations, and dissolutions for Catholic health care institutions.


A report on the joint appointment concept at the U. of Rochester.


The nurse specialist: catalyst for reuniting service and education.


Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. The importance of C5 in the generation of complement (C)-dependent chemotactic activity in vitro is well recognized. However, the actual role C5 may play in the accumulation of polymorphonuclear leukocytes (PMN) at inflammatory sites in vivo has not been established. Injection of glycogen or endotoxin into the peritoneal cavities of guinea pigs resulted, shortly thereafter, in the local accumulation of PMN. Preceding the influx of leukocytes, the peritoneal fluid became chemotactic for rabbit PMN in vitro. The majority of this activity could be attributed to a cleavage product of C5 (C5a). Similarly, injection of endotoxin into the peritoneal cavity of C5-normal mice resulted in the generation of a chemotactic factor for mouse PMN which was followed by the accumulation of PMN in the peritoneal fluid. In contrast, injection of endotoxin into the peritoneal cavity of C5-deficient mice resulted in the generation of virtually no detectable chemotactic activity and a markedly depressed accumulation of PMN during the first 24 hr after injection. The data suggest that C5 plays an important role in the early phases of PMN accumulation in response to inflammatory stimuli. The rapid accumulation of PMN in response to an inflammatory stimulus such as bacterial endotoxin would be expected to be a major factor in host defense against proliferation and dissemination of infectious agents.


Effect of growth hormone on the metabolism of thymus and on the immune response against sheep erythrocytes. The effect of pituitary growth hormone on the biosynthesis of DNA in the thymus and other lymphoid organs, as well as the ability of the rat to respond immunologically to sheep red blood cells, has been evaluated. There is a marked reduction in plaque-forming cells, hemagglutination titers, and DNA synthesis in animals when examined at 15 wk after hypophysectomy. Administration of bovine growth hormone (BGH) leads to the enhancement of DNA synthesis in lymphoid organs and recovery of the immune response. Similar effects of the hormone are observed in plateaued rats. Injection of rabbit anti-BGH globulins, in contrast to normal rabbit globulins, over 5 days causes a drop in the weight of the thymus and in the rate of DNA synthesis in this organ. The thymus is also the organ in which stimulation of DNA synthesis is observed at a time period earlier than the spleen and lymph nodes after a single injection of BGH. The hormone stimulates not only the incorporation of thymidine-(3)H into DNA in the cortical cells, but also the incorporation of sodium sulfate-(35)S into TCA-insoluble biopolymers reported to be elaborated in the medullary area of the thymus. An in vitro system for the action of BGH on the thymus has been described. There is an obligatory requirement for calcium, but not for fetal calf serum in the medium for the hormone effect. An early action of the hormone is the enhanced incorporation of uridine-G-(3)H into RNA in thymocytes which is followed by a stimulation of the synthesis of proteins and DNA. The stimulatory action of growth hormone on RNA synthesis is not because of a facilitated uptake of the radioactive uridine by the cells under hormonal influence, a mechanism by which insulin is observed to increase RNA synthesis in thymocytes in vitro. The action of growth hormone on thymocytes is specific, since thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and heat-inactivated growth hormone are not effective. BGH has also a beneficial action on the regeneration of the thymus and spleen in starved rats.


The role of thymus and bone marrow cells in delayed hypersensitivity. Adoptive transfer experiments were performed to define the immunological role of thymus and bone marrow cells in the induction of delayed hypersensitivity (DH). The results indicated the following, (a) Bone marrow from immune donors contained cells capable of being stimulated by antigen to initiate the expression of DH. (b) Bone marrow from nonimmune or tolerant donors contained cells that were needed to complete the expression of DH after the infusion of immune lymph node cells. (c) Normal bone marrow and thymus cells cooperated in the irradiated recipient to induce the most vigorous skin reactions to specific antigen; these reactions were seen only when the recipients were stimulated by antigen. Either cell type alone was ineffective. (d) In the presence of tolerant bone marrow cells, thymus cells from immune donors gave a more vigorous response than did thymus cells from normal or tolerant donors. (e) There was suggestive evidence that thymus cells were the source of trigger elements that initiated DH. (f) Antigen in the irradiated recipient was necessary to induce DH after infusion of bone marrow cells alone, or bone marrow and thymus cells together.


The peritoneal exudate lymphocyte. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs. Peritoneal exudate lymphocytes from guinea pigs immunized with horse radish peroxidase, dinitrophenyl guinea pig albumin, or ferritin in complete Freund's adjuvant have been shown to be significantly more reactive than other lymphocytes in two in vitro assays of cellular immune function: production of macrophage migration inhibitory factor and antigen-induced lymphocyte proliferation. The enhanced reactivity of peritoneal exudate lymphocytes cannot be accounted for by artifacts introduced by column purification or by the presence of nonlymphoid accessory cells. These observations suggest that the peritoneal exudate lymphocyte pool is a highly enriched source of cellular immune effector cells with specificity directed towards those antigenic determinants to which an animal has been recently exposed.


Lymphocyte-mediated cytotoxicity in vitro. Effect of enhancing antisera. The ability of antisera to suppress immune responses either in vivo or in vitro is well known. A variety of lymphocyte-target cell systems have been employed to demonstrate inhibition of cell-mediated immunity by antisera in vitro, and skin, tumor, and kidney graft survival have been prolonged by passively administered antiserum in vivo. An in vitro lymphocyte-tumor cell assay system was developed for the purpose of studying the effects of enhancing antisera (in vivo) on lymphocyte-mediated cytotoxicity in vitro. The characteristics of this system with respect to route of immunization, time of harvest of immune cells, lymphocyte:tumor cell ratio, and effect of nonimmune or nonspecifically immune lymphoid cells are presented. Sera capable of enhancement in vivo were tested in this system and shown to inhibit cell-mediated immunity in vitro. Further, in both instances the immunosuppressive effect is mediated by antigen-antibody complexes and not by free antibody alone. Experiments were also carried out to determine the site of action of these suppressive antigen-antibody complexes. Presensitized lymphocytes were exposed to antigen-antibody complexes, washed, and then allowed to interact with fresh tumor cells (not antibody treated). Lymphocytes treated in this manner are incapable of exhibiting cell-mediated immunity in vitro. This evidence supports the concept that the antigen-antibody complexes have a direct immunosuppressive effect on the lymphocyte.


Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. 3. Assembly of the three subclasses of IgG. The synthesis, assembly, and secretion of the three major subclasses of mouse IgG has been examined in 14 myeloma tumors and two cultured cell lines as well as in the cells from the popliteal lymph nodes of immunized mice. The total amount of IgG synthesized was between 15 and 43% of the cytoplasmic proteins made during a 15 min period. H(2) and H(2)L were the major precursors of IgG(2a) and IgG(1) but, in all of the tumors, HL was also an intermediate. In contrast, HL was a major precursor of IgG(2b). Most of the noncovalent and covalent assembly of IgG occurred after release of the newly synthesized H and L chains from the polyribosomes and assembly was not completed until 10 min or more after the synthesis of the polypeptide chains.


H-2-linked genetic control of immune responsiveness to ovalbumin and ovomucoid. Immune responsiveness of inbred mice to low doses of ovalbumin or ovomucoid is under control of single dominant genes closely linked to alleles of the H-2 locus. High responsiveness to ovomucoid is linked with the H-2(a) and H-2(k) alleles, and to ovalbumin with the H-2(b), H-2(d), and H-2(q) alleles.


Fibrillary accumulations in oligodendrogial processes of rats subjected to protocaval anastomosis.


Muscle fibre size in normal infants, children and adolescents. An autopsy study.


Cerebrospinal fluid in acute necrotizing encephalitis. Hypochlorrhachia as a diagnostic aid.


The influence of postnatal development on drug-induced hepatic porphyria and the synthesis of cytochrome P-450. A biochemical and morphological study. The mitochondrial enzyme delta-aminolevulinate synthetase (ALAS) controls the rate-limiting step in the synthesis of porphyrins and heme. An experimental form of hepatic porphyria can be readily elicited in laboratory animals, such as the rat, by drugs and foreign chemicals which are known to enhance the de novo formation of this enzyme in the liver. The present study shows that there is a striking refractoriness to the induction of ALAS during the perinatal period in the rat. Chemicals which have potent porphyria-inducing activity in adult animals have no significant inducing effect on hepatic ALAS in neonates. The ultrastructural changes which accompany the induction of ALAS by drugs and chemicals in adult liver also fail to take place in the livers of neonates. A progressive capacity for responding to the action of chemical inducers of hepatic ALAS does, however, develop in neonatal animals so that by approximately 5-6 wk of age experimental porphyria can be elicited as effectively in them as in adults. The reasons for the refractoriness of hepatic ALAS to induction in the perinatal period are not known; but the findings of this study make it clear that ALAS belongs to that increasingly large group of liver enzymes in mammals whose appearance, increase of activity, or inducibility is developmentally determined. The occurrence of developmental changes in the indicibility of ALAS in the liver of neonates also provided an opportunity to study the relationship of this enzyme activity to the drug-mediated induction of the hepatic hemoprotein cytochrome P-450. This inducible hemoprotein serves as the terminal oxygenase in the microsomal mixed-function oxidase system in the liver. The results of this study indicate that, in contrast to the refractoriness of ALAS to induction, significant drug-induced changes of hepatic P-450 content and of hemeprecursor incorporation into this cytochrome do take place in neonates. The synthesis of P-450 thus appears to be under a regulatory control different from that of ALAS in neonates, and the relation between ALAS activity and P-450 formation is not therefore a direct one.


Observations on the effect of levodopa on tardive lingual-facial-buccal dyskinesia.


Potentiation of the L-Dopa effect in man by the use of catechol-O-methyltransferase inhibitors.


Mental retardation in patients with Duchenne progressive muscular dystrophy.


The motor cortex and corticospinal tract of the armadillo (Dasypus novemcinctus).


Scintigraphic evaluation of the liver with schistosomiasis japonica.


Thyroid scintiphotography in 1,000 patients: rational use of  99m Tc and  131 I compounds.


Cisternography with  169 Yb-DTPA.

Cisternography with  169 Yb-DTPA.


Localization of polypeptide caseidin in the renal cortex: a new radioisotope carrier for renal studies.


Effect of pulse-height selection on lesion detection performance.


Artifacts in  99m Tc-sulfur colloid liver scans.


A moving line source for improved transmission scintiphotography.


99m Tc-DTPA preparations.

99m Tc-DTPA preparations.


Aluminum content in eluents from commercial technetium generators.


Receptor characteristics and conduction velocites in bladder afferents.


Channeling of responses elicited by hypothalamic stimulation.


The behavioral analysis of aphasia.

The behavioral analysis of aphasia.


Linguistic aspects of amnesia and confabulation.


Applications of the military medical model to civilian psychiatry.


Occupational socialization in the professions: the case of role innovation.


Psychological issues in training for research in psychiatry.


Diurnal oscillations in pineal melatonin content.


Daily variations in the concentrations of individual amino acids in rat plasma.


C.N.S. effect of nicotine as the discriminative stimulus for the rat in a T-maze.


The influence of low pH, high K and microinjected CaCl 2  on the ouabain-insensitive component of sodium efflux in barnacle muscle fibers.


Oral surgery. Cloxacillin for prophylaxis.


Anaphylactic reaction after sodium dehydrocholate (Decholin) use.


An unusual clivus meningioma.

An unusual clivus meningioma.


Surgical myocardial revascularization. A follow-up study.


Proper use of oxygen in respiratory therapy.


The pill and thyroid function.

The pill and thyroid function.


Acquired heart disease: a surgeon's view.


Progressive anterior horn cell disease.

Progressive anterior horn cell disease.


The challenge of the compound fracture.

The challenge of the compound fracture.


American medicine.

American medicine.


Lithium.

Lithium.


Cysts in the floor of the mouth.

Cysts in the floor of the mouth.


Treatment of the hospitalized alcoholic. Detoxification and rehabilitation.


Doctors Hospital follows the blips and the bleeps to management by instrumentation.


History of the treatment of compound fractures.


Computer system choice depends on hospital's needs.


How to tell the correct time-sharing..

How to tell the correct time-sharing..


More monitoring for less money in new system.


Automation: more tests without more staff.


Hospital of the month: hospital integrates modern technology and historic look.


Send some tests outside to improve laboratory inside.


Telephone and tape recorder simplify patient reports.


Small-town doctor needs more than an office.


Begin study of technician role.

Begin study of technician role.


These careless practices pose bacterial hazards for patients and employes.


Prescription for an H.M.O.: muscle, doctors and millions of bodies.


Managers lose control when they make any of these 14 mistakes.


Employe actions and admission policies can add liability.


Proper shelving minimizes costs and space.


Interview is time to ask tough questions.


Subcortical mediation of learned taste aversion.


EEG and multiple-unit activity in limbic and motor systems during movement and immobility.


An analysis of leg position learning in the cockroach yoked control.


Is satiety mediated by the ventromedial hypothalamus?


Hypervolemia at the polyethylene glycol induced onset of drinking.


A re-examination of the role of the ventromedial hypothalamus in feeding behavior.


Incidence of food-deprivation polydipsia in the white Swiss mouse.


Some aspects of drinking behavior in rats following lesions of the septal region of the forebrain.


Eating after intracrop preloading in the pigeon.


Reaction time histogram with the CAT computer.


Operant responding for food following lesions in the nuclei accumbens of the rat.


Effects of scopolamine on hippocampal theta and correlated discrimination performance.


Observations on the clinical use of nalidixic acid.


Radiology in urinary infection.

Radiology in urinary infection.


Urinary tract infections. The need for treatment.


Urinary tract infection in childhood.

Urinary tract infection in childhood.


Uncomplicated urinary tract infection in women.


Preliminary study on sterilization of mosquitoes by chemosterilants.


The difference in mortality rate of larvae of dieldrin resistant and susceptible strains of Culex pipiens fatigans when reared together in confined containers.


A modification of the ear-feeding technique for rearing trombiculid larvae (Acarina: Prostigmata).


Serum vitamin B 12  level in patients with amoebic liver abscess, opisthorchiasis and hookworm infections.


A new method of assessment of riboflavin status: its use in Thailand.


Electron microscopic study of Balantidium from man.


Human Vibrio cholerae: a histologic review of 117 cases in the Philippines.


A leptospirosis study in South Sumatra and Bangka Island, Indonesia.


Acute viral hepatitis in thailand: a clinical study of 118 cases.


Clinical trial of phenyelene di-iso-thiocyanate (1.4), Jonit, in the treatment of hookworm disease in Malaysia.


Ixodes holocyclus larvae and 'scrub-itch' in southeast Queensland.


Coccidia (Protozoa: Eimeriidae) of wild mammals in Malaysia.


Family dynamics in male transsexualism.

Family dynamics in male transsexualism.


Physiologic differentiation of sexual arousal and anxiety.


A freak specimen of Aedes (Stegomyia) albopictus (Skuse, 1894) from Malaysia (Diptera: Culicidae).


Operant conditioning of heart rate in patients with premature ventricular contractions.


Revolution, relevance and psychosomatic medicine: where the light is not.


The phlebotomine sandflies of Malaysia (Diptera: Psychodidae).


The development of a filarial worm in the fet body of a mosquito.


Chromoblastomycosis.

Chromoblastomycosis.


Emotional and adrenal reactions to stress in bronchial asthma.


Solitary pulmonary cryptococcoma.

Solitary pulmonary cryptococcoma.


Isolation of Toxoplasma gondii from guinea pigs in Singapore.


Further studies of Coccidia (Protozoa: Eimeriidae) from Malaysian mammals.


Experimental infection of Plasmodium berghei in the fruit bat, Dobsonia moluccensis, after splenectomy.


Intestinal parasitic infections in an estate hospital (rubber, oil palm) in Selangor State, Malaysia.


Preliminary studies on the mode of nutrition of infective larvae of Breinlia sergenti.


Viability of infective filarial larvae after periods of refrigeration.


Inoculation of infective larvae of sub-periodic Brugia malayi into domestic cats by various routes.


Abnormally long microfilariae found in periodic Brugia malayi infections in man and cat.


Preliminary observations on the adult worms of Brugia malayi in experimentally infected cats.


A note on sheated and unsheathed appearance of periodic and sub-periodic Brugia Malayi in southern Thailand.


A trial on the transmission of periodic Brugia malayi from man to cats.


The ultrastructure and life history of Rhinosporidium seeberi.


Symposium on acid-peptic disease. Foreword.


Inhibition of thrombin and autoprothrombin C (F-X a ) as a mutual depletion system.


Quantitative effects of the reaction between factor VIII and factor VIII inhibitors.


The action of an aniline derivative (AN 162) on blood coagulation and on platelets.


Studies on liver factors which exert an inhibitory effect of platelet aggregation. The identification and characterization of platelet aggregation inhibitors from rabbit liver.


An intrinsic blood platelet abnormality in an homocystinuric boy, corrected by pyridoxine administration.


Standardisation of the one-stage prothrombin time test for the control of anticoagulant therapy. The availability and use of thromboplastin reference preparations.


Hageman factor activity in liquoid-induced consumption coagulopathy. Failure to prevent the drop in Hageman factor activity by anticoagulation with a coumarin derivative.


A comparison of methods for platelet lysis and the isolation of platelet membranes.