Memory in the Japanese quail: effects of puromycin and acetoxycycloheximide. Intracerebral injections of puromycin produced memory deficits in naive quail trained to discriminate between red and green stimuli. Puromycin aminonucleoside, acetoxycycloheximide, and saline had no such effect. After a single reversal of the visual cues, naive quail treated with puromycin performed better than control birds. Also, puromycin had no effect on performance when injected into previously trained animals. High doses both of puromycin and acetoxycycloheximide inhibited ribonucleic acid and protein synthesis to a similar extent, while low doses of puromycin inhibited only protein synthesis. Since only puromycin inhibited memory, the basis for its effect appears more likely to be mediated by the action of peptidyl-puromycin rather than by the quantitative inhibition of macromolecular synthesis or by some nonspecific toxic action.


Drainage of massive hydronephrosis with large bowel conduits.


Pseudocysts of the pancreas: value of urine and serum amylase levels.


Blood loss during adenotonsillectomy.

Blood loss during adenotonsillectomy.


Sudden hyperpyrexia during general anesthesia.


Recurrent embolism from an occult crutch aneurysm of the axillary artery.


A comparison of adenosine triphosphate levels in hemorrhagic and endotoxic shock in the rat.


Experimental investigations of the role of hemodynamic factors in formation of intimal changes.


Effect of chlorpromazine on peripheral blood flow.


Terpenoid alkaloids from Murraya koenigii Spreng. II. The constitution of cyclomahanimbine, bicyclomahanibine, and mahanimbidine.


Photochemical desulfurization of methylthio-S-triazines.


The oxidation of mercaptans by flavins.

The oxidation of mercaptans by flavins.


Photochemical transformation of N-(P-toluenesulfonyl)diphenylcyclopropenimine.


Electron microscopy of Crotalaria pulmonary hypertension.


Chronic bronchitis in coal miners: ante-mortem-post-mortem comparisons.


Results of surgical repair of atrial septal defects in the middle-aged and elderly.


Surgical management of traumatic cardiac fistulae.


Echinococcal tension pneumothorax.

Echinococcal tension pneumothorax.


Pectus excavatum.

Pectus excavatum.


Cardiac arrhythmias following pneumonectomy.


Radiographic abnormalities in carcinoma of the lung as related to histological cell type.


Trephine biopsy of the lung and pleura.

Trephine biopsy of the lung and pleura.


Mediastinoscopy: a clinical evaluation of 400 consecutive cases.


Simultaneous measurement of intraluminal pressure and pH in the stomach and oesophagus. With special reference to the diagnosis of hiatal hernia and hiatal incompetence.


Prevention of reflux from the stomach into the oesophagus.


Bronchial cartilage in chronic bronchitis.


Distribution of bronchial gland measurements in a Jamaican population.


Emphysema in a non-industrialized tropical island.


Haemodynamic measurements prior to ventricular fibrillation or asystole following experimental coronary occlusion.


Entire left atrial myxoma presenting as a saddle embolus.


Parachute deformity of the mitral valve.


Sternal retractor for improved vision during bilateral internal mammary artery implantation.


Effect of irradiation on bound water in mouse thymus.


Equilibrium function in scoliosis and active corrective plaster jacket for the treatment.


Studies on fractionated irradiation. I. Response of mitotic cells in tumors to fractionated irradiation with different doses and intervals.


Studies on fractionated irradiation. II. Effect of fractionation of irradiation with a constant dose and overall time on mitosis of Ehrlich tumor cells.


Studies on fractionated irradiation. IV. Effect on suppression of mitosis of the interval between fractionated irradiation.


Effect of amino acid supplementation on growth of school children.


The development and research of electrically powered artificial upper limbs.


Bronchospasm possible due to gallamine. A case report.


Fermentation of primycin.

Fermentation of primycin.


Effect of reflexes of somatic afferents on the adrenergic outflow to the stomach in the cat.


Properties of Clarke's column neurones.

Properties of Clarke's column neurones.


Elicitation of reflex vagal relaxation of the stomach from pharynx and esophagus in the cat.


Changes in the activity of isolated vascular smooth muscle in response to reduced osmolarity.


Temperature dependence of cholinesterase and lactate dehydrogenase in the guinea-pig, hedgehog and codfish.


Changes in the cell volume of isolated vascular smooth muscle in response to reduced osmolarity.


Immunizations. Comprehensive health care and changing professional roles.


Local transmitter concentrations in vascular smooth muscle during vasoconstrictor nerve activity.


Etiology and management of severely burned children. Psychosocial considerations.


Reflex responses induced by stimulation of hypoglossal afferents.


Diagnosis of appendicitis in infancy. The value of abdominal radiographs.


Hyperosmolality and vasodilatation in human skeletal muscle.


Acute rheumatic fever in Shiraz, Iran. Its prevalence and characteristics in two socioeconomic groups.


Streptococcal pharyngitis. Evaluation of erythromycin, erythromycin-sulfas, and sulfamethoxazole (possible antagonism between erythromycin and sulfas).


The accumulation of albumin-125-I and thyroxine-131-I in wounds.


Design and operation of a van for the transport of sick infants.


Sweating capacity of neonates. Nicotine-induced axon reflex sweating and the histamine flare.


The effect of acetazolamide upon tissue concentrations of bicarbonate, lactate, and pyruvate in the rat brain.


Heart failure due to enlarged tonsils and adenoids. The cardiorespiratory syndrome of increased airway resistance.


Serial bilirubin concentrations in low birth weight infants.


Hemodynamics in the bone marrow of anemic rabbits with increased hematopoiesis.


Determination in inulin, albumin and erythrocyte spaces in the bone marrow of rabbits.


Lymphopenic agammaglobulinemia (Swiss type) in Chicago. Autosomal recessive form.


A study of bone density. Comparison of the effects of sodium fluoride, inorganic phosphates, and an anabolic steroid (oxymetholone) on demineralized bone.


Conditional reflex activation of the sympathetic cholinergic vasodilator nerves in the dog.


Radiological case of the month. Primary hyperparathyroidism.


Congenital cystic adenomatoid malformation of the lung. Report of a case and review of the literature.


The firing pattern of dorsal spinocerebellar tract neurones during inhibition.


Cervical hernia of the lung associated with the cri du chat syndrome.


The evolution of vascular smooth muscle responses to histamine and 5-hydroxytryptamine. II. Appearance of inhibitory actions of 5-hydroxytryptamine in amphibians.


Pulmonary function and G-stress during inhalation of 100 percent oxygen.


Farmer's lung in an adolescent boy.

Farmer's lung in an adolescent boy.


The effect of aldosterone in vitro on the active sodium transport and moulting of the frog skin.


Complication of a circumcision performed with a plastic bell clamp.


Neonatal Klinefelter's syndrome.

Neonatal Klinefelter's syndrome.


The heat regulation of the human body.

The heat regulation of the human body.


Coccidiodomycosis--possible fomite transmission. A review and report of a case.


Transcellular permeability of capillaries in experimental cholera.


Fine structure of the bond between platelets in artificial thrombi and in platelet aggregates induced by adenosine diphosphate.


Liver regeneration and the "critical mass" hypothesis.


Electron microscopy of gastric mucosa from puromycin-treated rats.


Animal studies comparing the neuropharmacological profile of a trifluoperazine HCl-amobarbital combination with that of the individual components.


Antioxytocic action of saponin isolated from Asparagus racemosus Willd (Shatavari) on uterine muscle.


Vasoactive polypeptides and potassium exchange between the blood and cerebrospinal fluid.


Effect of glucagon and phenformin upon K42 movement from plasma to cerebrospinal fluid.


4-Dimethyl-amino methyl-2-methyl 1,3 dioxolane--a new potent analgesic agent.


Time-course of the epinephrine response of hypoxic rabbit aorta.


Comparison of learning impairment and activity depression produced by two classes of cholinergic blocking agents.


Adrenergic dilatation in the isolated guinea pig lung.


The influence of reserpine, propranolol, and adrenal medullectomy on the hyperglycemic actions of theophylline and caffeine.


The effect of diazoxide on glucose disappearance in eviscerated dogs.


Failure of plasma from schizophrenics to potentiate the effects of 3,4-dimethoxyphenylethylamine on rats and mice.


The nature of neuromuscular block produced by neomycin and gentamicin.


The effects of N-methylation on the pharmacological activity of phenethylamine.


Tachyphylaxis to the inhibitory action of atroine on the cholinergic response to nicotine, in vitro.


Inhibition of urease by hydroxamic acids.


Effect of the antioxidant nordihydroguaiaretic acid on the in vitro activity of catechol-o-methyl transferase.


Cardiac metabolism during hypothermia.

Cardiac metabolism during hypothermia.


A new tremorgen: 3,4-dimethylphenethylamine.


Effect of microsomal enzyme modifiers on toxicity and therapeutic activity of cyclophosphamide in mice.


The effect of 1,1-(2,7-dimorphocino-6-phenyl-4-pteridinyl-imino) di-2-propanol (RE102), a dipyridamol derivative, upon the general and cardiac haemodynamics of the intact dog.


Brain amine changes in stressed and normal rats pretreated with various drugs.


Thiobarbiturate anesthesia: a comparative study and statistical analysis in the dog.


The geographical comparison of mortality from cancer of the stomach and ulcer of the stomach in Japan.


Malignant tumours of the male breast in Finland. A report of 51 cases.


Thyroid cancer in Israel.

Thyroid cancer in Israel.


The growth and cell population kinetics of spontaneous tumours in domestic animals.


The growth curve of the rat thyroid under a goitrogenic stimulus.


The short term effects of x-radiation on goitrogen induced growth of the rat thyroid.


The metabolism of 4-acetamidostilbene and its N-hydroxy derivative.


An elementary theory leading to non-linear dose-risk relationships for radiation carcinogenesis.


A histological study of chromatin positive and negative hydatidiform moles.


Secretion from the cortex-free bovine adrenal medulla. 1. The isolated bovine adrenal medulla was prepared from whole glands by careful removal of the cortex. The tissue was perfused with physiological salt solution and stimulated with a variety of secretogogues.2. Catecholamines were secreted from the tissue upon stimulation with carbamylcholine, nicotine sulphate, acetylcholine bromide, histamine dihydrochloride, (+)-amphetamine sulphate and potassium chloride.3. Carbachol-induced secretion of catecholamines was reduced in the presence of either hexamethonium bromide or tetracaine hydrochloride, during perfusion with calcium-free perfusion fluid, or during perfusion at low temperature.4. Stimulation of the medulla with carbachol also led to secretion of chromaffin granule protein and acid deoxyribonuclease. The relationships between catecholamines secreted and the amounts of these proteins secreted were similar to the corresponding values for the perfused whole bovine adrenal gland. Perfusate lactate dehydrogenase activity and perfusate haemoglobin content were unchanged after carbachol stimulation.5. It is concluded that there are no differences in the mechanisms for catecholamine secretion from the cortex-free perfused medulla and the perfused whole gland.


The effect of bretylium on intracellular cardiac action potentials in relation to its anti-arrhythmic and local anaesthetic activity. 1. The initial effect of bretylium tosylate on isolated rabbit atria was to increase conduction velocity, contraction heights, spontaneous frequency and maximum driven frequency, and to reduce electrical threshold. At concentrations of 200 mg/l. or less, these were the only effects, and were consistent with the known sympathomimetic actions of bretylium.2. At extremely high concentrations, 1,200 and 2,400 mg/l., the initial actions were succeeded by weak quinidine-like effects; reduced conduction velocity, spontaneous and maximum driven frequencies, and rate of rise of action potential. The electrical threshold was raised, but contraction heights were not reduced.3. The local anaesthetic activity of bretylium, measured by reductions in the frog nerve action potential, was 1/90 that of procaine and 1/300 that of propranolol, on a molar basis.4. Acute pretreatment with bretylium, 20 mg/kg intravenously, significantly increased the amount of infused ouabain required before the appearance of the first signs of atrial arrhythmia in anaesthetized guinea-pigs, but did not prevent ventricular arrhythmias.5. Pretreatment with bretylium 30 mg/kg subcutaneously 24 hr, and again 4 hr before ouabain infusion, increased the dose of ouabain inducing atrial irregularity and slightly but significantly reduced the incidence of ventricular fibrillation.


Some properties of the denervated anterior gracilis muscle of the rat. 1. Microdrops of acetylcholine (ACh) were topically applied to denervated, mammalian skeletal muscle in vivo, and ACh-evoked depolarization and contracture were recorded simultaneously.2. Contracture tension was directly proportional to the degree of ACh-elicited depolarization.3. Atropine and (+)-tubocurarine increased the amount of ACh required to produce a given amount of depolarization, but these anticholinergic agents did not alter the relationship between the degree of ACh-evoked depolarization and contracture tension.4. Topically applied catecholamines did not produce either depolarization or contracture, despite the fact that parenterally administered catecholamines elicited both responses.


The synthesis and pharmacology of some 1,4,5,6-tetrahydropyrimidines. 1. Several 1- and 2-substituted, and 1,2-disubstituted, 1,4,5,6-tetrahydropyrimidines have been prepared and their toxicological and pharmacological properties have been investigated.2. In general the compounds were neuromuscular blocking agents with the monosubstituted members of the series showing a depolarizing type of activity and the disubstituted compounds a non-depolarizing type.3. The toxicity to mice of some of the monosubstituted compounds was increased by pretreatment of the animals with SKF 525A, but the toxicity of the disubstituted compounds was unaffected.4. The results obtained with these compounds are not at variance with a suggestion made previously that nicotinic action at the neuromuscular junction can result from an interaction between drug and receptor at two points separated by about 4 A.


Tremor induced by tetrabenazine.

Tremor induced by tetrabenazine. 1. Acute administration of tetrabenazine produced tremor in cats, in doses which caused sedation but not hypothermia.2. The pattern of movements resembled shivering rather than Parkinsonism, and warming the skin suppressed the tremor.3. The tremor was not influenced by hyoscine.4. Tremor produced by amylobarbitone was essentially similar to that induced by tetrabenazine.


Comparison of effect of morphine-like analgesics on transmurally stimulated guinea-pig ileum. 1. Morphine-like analgesic drugs caused depression of twitches of the isolated guinea-pig ileum in response to transmural electrical stimulation. The drugs tested were the narcotic analgesics codeine, diamorphine, fentanyl, morphine, morphine-N-oxide, normorphine, oxymorphone, pethidine, phenazocine and phenoperidine and the analgesic narcotic antagonists nalorphine and pentazocine.2. With the first application of one of these drugs the extent of depression of twitches was proportional to concentration. Except in the case of pethidine, there was no further depression when additional drug was added to the organ bath. With the second application of a drug after washing out the first dose, the depressant effect was less; that is, tolerance developed. With pethidine, the depression of twitches was proportional to concentration and tolerance could not be observed.3. When tolerance had been produced by cumulative addition of these drugs, a concentration was reached at which further addition resulted in increased activity of the ileum.4. With codeine, morphine and normorphine, the twitches were increased in height and regular.5. With diamorphine, fentanyl, oxymorphone, pentazocine, phenazocine and phenoperidine there were increased but irregular responses to transmural stimulation.6. Having reached the concentration at which these effects were observed, washout of the drug resulted in reduction of activity; the twitches became smaller or the irregular responses ceased.7. Readministration of a drug after activity of the ileum had been depressed by withdrawal of that drug resulted in restoration of activity, the ileum being dependent on the presence of the drug for its activity.8. Codeine and nalorphine did not produce as great an increase in activity on readministration to a dependent ileum as did morphine: they seem to act as partial agonists in producing this effect.9. In similar experiments with the isolated urinary bladder of the rat and guinea-pig, morphine was less active in depressing responses to stimulation than it was on the ileum, and tolerance to the drug and dependence on it did not occur.10. These observations have been discussed in relation to analgesic activity, tolerance and dependence in man.


Uptake of antimony potassium tartrate by mouse liver slices. 1. The uptake of (124)Sb-antimony potassium tartrate by isolated mouse liver slices has been measured and found to establish high tissue: medium concentration ratios.2. Uptake was not influenced by oxygen lack, potassium, ouabain, dinitrophenol or sodium arsenate. It was inhibited by dimercaprol and reduced at low temperature. No evidence was found of counter-transport. After subcellular fractionation, most of the radioactivity was recovered from particulate fractions.3. Kinetic studies of uptake from media containing different concentrations of antimony suggest that uptake is due partly to diffusion and partly to a saturable binding mechanism, probably involving chelation by non-diffusible thiol groups. Saturation studies suggest that only a small proportion of thiol groups bind antimony, the remainder undergoing catalytic oxidation.


Enhancement of inflammation and histamine formation by actinomycin D. 1. An inflammation model developed in other laboratories was used in this study. Mice given endotoxin intranasally developed lung inflammation which progresses in intensity for several days. Lung weight is a satisfactory measure of inflammation.2. In lungs of mice treated intranasally with endotoxin, histidine decarboxylase was activated within 6 hr, before lung weight had increased substantially. Enzyme activity was near maximal at 24 hr but had dropped by 48 hr, at which time inflammation was increasing. The data are consistent with an early role for histamine in mediating inflammation, but not with an essential role in the later stages.3. When actinomycin D, an inhibitor of RNA synthesis, was mixed with endotoxin solution and given to mice intranasally, both lung inflammation and histidine decarboxylase activation were markedly enhanced at 24 and 48 hr, relative to effects produced by endotoxin alone.4. Evidence is presented that intranasal instillation of endotoxin into mice increases histamine formation in lung in vivo.5. We previously found protein synthesis inhibitors, the only drugs shown capable of blocking histidine decarboxylase activation, to be powerful anti-inflammatory agents. Now we have found that actinomycin D, the only drug shown capable of enhancing histidine decarboxylase activation, to be strongly pro-inflammatory. These observations support a causative role for histamine in slowly-developing inflammation, and also provide a rigorous test for the participation of other mediator candidates.


The effect of aflatoxin on blood clotting in the rat. 1. The action of aflatoxin on blood clotting of rats was investigated. Aflatoxin B(1) prolonged the blood clotting time of rats.2. Aflatoxin B(1) was effective as an anticoagulant in much smaller doses than 4-hydroxycoumarin.


Some anticholinergic activities of BRL 1288--a new anti-Parkinson drug.


Behaviour and EEG are affected on the day after hypnotic doses of nitrazepam and amylobarbitone sodium.


Opioid and muscarinic anti-nociception.

Opioid and muscarinic anti-nociception.


The effects of drugs on the hyper-reactivity of rats with bilateral anterior hypothalamic lesions.


Interactions of oestrogenic and progestational steroids with dexamphetamine and fencamfamin in mice.


Ambient temperature and thermal responses to hexamethonium in the mouse.


Nicotine uptake by isolated rat ganglia.


Pharmacological studies of cinanserin in human isolated smooth muscle.


The influence of adrenocortical insufficiency on cardiac muscle.


Two types of adrenoreceptor in the isolated frog heart.


The effects of carbochromen on myocardial blood flow and metabolic heat production before and after acute coronary ligation.


A comparison of the effects of bretylium, lignocaine and propranolol on experimental cardiac arrhythmias.


Cardiovascular actions of glucagon and secretin.


The excretion of hydroxyphenyltrimethylammonium in bile.


A possible explanation for the varied effects of sulphonic acid diesters on spermatogenesis.


Chemosterilant action of trimethylphosphate in rodents.


Effects of ethylene dimethanesulphonate on reproductive function in rats.


Isolation of a new oxytocic peptide from bovine posterior pituitary lobes.


A model to demonstrate the inhibition by dexamethasone of anaphylactic bronchoconstriction.


Pulmonary mechanical changes in experimental bronchitis.


Disulphide bond reduction in nicotinic receptors.


An apparatus for measuring passive resistance to movement of the forearm in man.


Electroanaesthesia as a pharmacological technique.


Spontaneous and drug-induced electrical changes in longitudinal muscle strips from the rabbit duodenum.


The estimation of amylobarbitone and hydroxyamylobarbitone in serum by gas liquid chromatography.


A technique for the continuous micro-infusion of chemicals into discrete parts of the brain in unrestrained rats.


The evaluation of anaphylactic bronchoconstrictor effects induced by intravenous and aerosol challenge in the anaesthetized guinea-pig.


The quantitative evaluation of skin reactions in cases of delayed hypersensitivity.


Cholinesterases and cholineacetylase in the nervous system of the rat.


The affinity and activity of compounds related to nicotine on the rectus abdominis muscle of the frog (Rana pipiens). 1. Series of pyridylalkyl- and substituted phenylalkyl-trimethylammonium salts, triethylammonium salts, diethylamines and di-n-propylamines have been made. The substituents in the benzene ring were nitro, chloro, bromo, methoxy, hydroxy and amino groups and the alkyl residues had one, two, or three methylene groups separating the aromatic nucleus from the cationic head.2. Most of the trimethylammonium compounds caused a contracture of the frog rectus muscle, but some were partial agonists and a few were antagonists. The di-n-propylamines were all antagonists, as were most of the diethylamines and triethylammonium compounds, though some of these were partial agonists and a few triethylammonium compounds were agonists. The affinities of the antagonists and partial agonists for the receptors stimulated by beta-pyridylmethyltrimethylammonium (and by nicotine) were measured. The equipotent molar ratios of all the agonists were measured relative to beta-pyridylmethyltrimethylammonium.3. The dissociation constants of the pyridylmethyldiethylamines and substituted benzyldiethylamines were measured. The effects of substituents on the pK(a) of benzyldiethylamine were similar to their effects on the pK(a) of aniline, though there were differences with some of the o-substituted compounds, which could be attributed to internal hydrogen-bond formation.4. There is no obvious correlation between the effects of a substituent on the pK(a) of benzyldiethylamine and its effects on affinity. Although increasing the size of the cationic group usually increased affinity, it did not always do so. The compounds with the highest affinity, p-hydroxybenzyldiethylamine (log K, 5.90) had about half the affinity of (+)-tubocurarine (log K, 6.11), but the triethylammonium analogue (log K, 4.17) had only about one-fiftieth of the affinity of the tertiary base. The binding of the drug to the receptor appears to involve many factors which include the size of the groups as well as their electron-releasing or withdrawing nature and other properties, such as their polar and lipophilic or lipophobic character.5. There is no obvious correlation between the effects of a substituent on the affinity of the diethylamino or triethylammonium compounds and its effects on the activity of the trimethylammonium analogue. The most active compounds contain hydroxy- and amino-, phenyl or beta-pyridyl groups, m-hydroxyphenyl-propyltrimethylammonium being about 50 times as active as nicotine, but the corresponding diethylamino or triethylammonium compounds do not have high affinity. There does not seem necessarily to be an inverse relationship between activity and affinity, however, because some m-nitro and m-chloro trimethylammonium compounds have considerable activity and the analogous triethylammonium compounds have considerable affinity.6. It is suggested that ability to activate these receptors is associated with the presence of substituents which can interact with water molecules which may be involved in the action of the drug at the receptor.


The pulmonary and systemic circulatory response to dopamine infusion. 1. The pulmonary and systemic circulatory responses to dopamine infused at 8, 15, 25 and 30 mug/kg per min were studied in eight mongrel dogs.2. Mean pulmonary artery pressure, mean left atrial pressure, mean aortic pressure, mean aortic flow and the electrocardiogram were monitored in openchest preparations. Pulmonary vascular resistance, systemic vascular resistance and stroke volume were calculated.3. Significant increases in mean pulmonary and aortic pressures were noted at dopamine infusions of 25 and 30 mug/kg per min. The left atrial pressure fell significantly at 15 mug/kg per min and rose significantly at 30 mug/kg per min. Mean aortic flow increased at all four doses, while heart rate showed no change. Pulmonary vascular resistance did not change significantly at any dose level, but systemic vascular resistance fell slightly at 8 and 15 mug/kg per min and rose significantly at 30 mug/kg per min. Stroke volume was significantly elevated at infusions of 25 and 30 mug/kg per min.4. The systemic circulatory response to dopamine is similar to that described by previous investigators.5. The increased pulmonary pressures without change in resistance suggest a dopamine-induced increase in smooth muscle tension in the pulmonary vasculature.


Effects of phenoxybenzamine on the uptake and metabolism of noradrenaline in the rat heart and vas deferens. 1. In the isolated rat heart perfused with various concentrations of (+/-)-(3)H-noradrenaline ((3)H-NA) the addition of phenoxybenzamine, cocaine or desipramine to the perfusion medium resulted in an inhibition of (3)H-NA uptake which appeared on kinetic analysis to be of a competitive nature.2. Phenoxybenzamine also blocked the formation of labelled metabolites of (3)H-NA in the heart at all perfusion concentrations of (3)H-NA; this effect appeared to be unrelated to the inhibition of the neuronal uptake of NA produced by phenoxybenzamine, since no blockade of (3)H-NA metabolism was produced by cocaine in similar experiments.3. In slices of rat vas deferens incubated with various concentrations of (3)H-NA, cocaine and desipramine and phenoxybenzamine were also shown to act as competitive inhibitors of NA uptake. Cocaine and phenoxybenzamine were less potent inhibitors of uptake in the vas deferens than they were in the heart; desipramine was equally potent in both tissues.4. When vas deferens slices were incubated in a medium containing phenoxybenzamine for 30 min before the addition of (3)H-NA, the resulting inhibition of (3)H-NA uptake was increased and changed to a non-competitive type of interaction.5. In hearts or vasa deferentia taken from animals pretreated in vivo with phenoxybenzamine (20 mg/kg), a significant inhibition of (3)H-NA uptake was found when the tissues were exposed to low concentrations of (3)H-NA but not when higher concentrations of (3)H-NA were used.


The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart. 1. (+/-)-(3)H-NA and labelled metabolites of NA were estimated in rat hearts after perfusion with various concentrations of NA in the range 0.01-50.0 mug/ml. Labelled metabolites of NA accounted for only a small proportion of the total uptake of radioactivity at low perfusion concentrations, but accounted for 50% of the total uptake at 1 mug NA/ml., thereafter declining to progressively smaller proportions at higher perfusion concentrations.2. If the formation of labelled metabolites of (3)H-NA was blocked by a combination of monoamine oxidase and catechol-O-methyl transferase inhibitors, the accumulation of unchanged (3)H-NA was doubled when hearts were perfused with 1 mug NA/ml.3. In hearts perfused with 0.5 mug NA/ml., an accumulation of unchanged (3)H-NA was demonstrated in the presence of a combination of metabolic inhibitors and metaraminol. This appeared to be due to Uptake(2), since the accumulation of NA under these conditions could be prevented by a low concentration of normetanephrine.4. Phenoxybenzamine prevented extraneuronal uptake (Uptake(2)) and metabolism of (3)H-NA with an estimated ID50 of 2.5 muM. The inhibition of Uptake(2) by phenoxybenzamine (2.0 muM) was diminished at very high NA concentrations, suggesting that the drug may act competitively with NA.5. It was concluded that Uptake(2) operates at all catecholamine concentrations in the rat heart, but that in the lower range (less than 2.5 mug/ml. for NA and less than 0.75 mug/ml. for adrenaline) any catecholamine taken up by this process is rapidly metabolized. Thus the accumulation of unchanged amine is seen only at high perfusion concentrations.6. The relevance of these results to an understanding of the possible physiological and pharmacological importance of Uptake(2) is discussed.


Histamine formation in rat gastric mucosa and lung after injecting reserpine or adrenaline. 1. In rats the effect of reserpine, adrenaline and gastrin on the histamine forming capacity (HFC) of gastric mucosa and lung was examined.2. Intraperitoneal reserpine as well as subcutaneous adrenaline produced a great increase in HFC of gastric mucosa but a great decrease in HFC of lung. After reserpine the HFC of lung was almost abolished.3. As the HFC changes produced by reserpine occurred also after demedullation of the suprarenals--the changes in the mucosa were in fact accentuated--release of the medullary hormones by the reserpine does not account for these changes.4. Subcutaneous gastrin caused a great increase in HFC of the gastric mucosa but did not affect the HFC in lung.5. The possible role of release of gastrin and corticosteroids for the reserpine-induced HFC changes is discussed because it is known that reserpine releases gastrin and corticosteroids and that cortisone produces HFC changes in gastric mucosa and lung.


The pharmacology of salivary myoepithelial cells in dogs. 1. Pressure changes in the submaxillary and parotid ducts of dogs, induced by nerve stimulation or intravenous injection of drugs, were studied.2. Pressure rises could be elicited by parasympathetic stimulation and by acetylcholine and methacholine, even when no secretion was evoked. These effects were abolished by atropine.3. Similarly, sympathetic stimulation, adrenaline, noradrenaline and phenylephrine raised the pressure in both glands, also in the absence of secretion. Dihydroergotamine abolished these effects. Isoprenaline increased the pressure in the submaxillary duct, but only when it caused secretion. This effect was abolished by propranolol. In the parotid gland isoprenaline caused neither secretion nor pressure rise. It is concluded that the myoepithelial cells of the two glands are supplied with alpha-adrenoceptors.4. Doses of histamine, bradykinin, kallidin and physalaemin which caused no salivary secretion raised the duct pressure even when dihydroergotamine, propranolol and atropine had been given.5. Angiotensin and 5-hydroxytryptamine increased the pressure only in some experiments. Oxytocin caused very little or no pressure rise. Vasopressin had no effect of its own but reduced the pressure raising effects of nerve stimulation or drugs.


Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets. 1. The influence of sodium and potassium on the accumulation of 5-hydroxytryptamine (5-HT) by rat blood platelets was investigated.2. An absolute dependence of 5-HT uptake on the sodium concentration in the medium was found.3. Removal of potassium reduced the uptake by about 60%. High concentrations of potassium inhibited sodium-dependent accumulation.4. The observations have been discussed in terms of a carrier-mediated transport process for 5-HT operating in the platelet membrane.


The release of prostaglandin E1 from the rat phrenic nerve-diaphragm preparation. 1. The release of prostaglandin E(1) from the rat phrenic nerve-diaphragm preparation during tetanic contraction of the muscle in response to nerve stimulation is reported. Tentative identification of the prostaglandin depended on solvent extraction column and thin-layer chromatography and parallel biological assay.2. Polar lipid substances were released from the preparation in the absence of nerve stimulation by (+)-tubocurarine and noradrenaline.3. The output on nerve stimulation was not abolished by (+)-tubocurarine, hemicholinium, bretylium or phenoxybenzamine added to the bath.4. The possible origin of these prostaglandins is discussed.


Effects of immobilization on rat liver tryptophan pyrrolase and brain 5-hydroxytryptamine metabolism. 1. Rat liver tryptophan pyrrolase increased on immobilization. The concentration of 5-hydroxyindoleacetic acid in the brain also rose and that of 5-hydroxytryptamine fell.2. When adrenalectomized rats were immobilized pyrrolase activity did not rise and brain 5-hydroxytryptamine concentration fell to a lesser extent but the 5-hydroxyindoleacetic acid concentration rose as in intact animals.3. When intact rats were injected with the pyrrolase inhibitor Allopurinol both the increase of pyrrolase and the fall of 5-hydroxytryptamine on immobilization were less prominent but the concentration of 5-hydroxyindoleacetic acid rose as before. Allopurinol did not affect the changes in immobilized adrenalectomized rats.4. Immobilization thus appears to cause (a) decreased brain 5-hydroxytryptamine synthesis resulting from pyrrolase induction and (b) increased 5-hydroxytryptamine breakdown by a more direct effect on the brain. Results of experiments on rats injected with lysergic acid diethylamide, and with alpha-methyltryptophan or probenecid are consistent with the above interpretation.5. The 5-hydroxytryptamine and 5-hydroxyindoleacetic acid changes were maximal after 5-6 hours' immobilization and became less on more prolonged immobilization, which suggests regulatory changes.


Prostaglandins A1,A2 and 19-hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds. 1. Prostaglandins A(1), A(2) and 19-hydroxy A(1) have qualitatively similar actions to prostaglandin E(1) on smooth muscle.2. The prostaglandins A have little activity on gastrointestinal, respiratory and reproductive smooth muscle but are potent depressors of the systemic arterial blood pressure of the dog, cat and rabbit.3. Our experiments support the view that the depressor action of the prostaglandins E and A is due to a direct dilator action on many peripheral vascular beds and not due to changes in nervous tone to these beds.4. A single passage through the pulmonary circulation of the cat or dog causes substantial loss of the vasodilator activity of prostaglandin E(1) but little if any loss of the vasodilator activity of the prostaglandins A.5. A single passage through the hepatic portal circulation of the cat causes substantial loss of the vasodilator activity of prostaglandins E(1), A(1) and A(2).6. The cat blood pressure and rat fundal strip would be a suitable combination for the parallel biological assay of the prostaglandins A(1) and A(2).


Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic. 1. Serum levels, half-lives and urine concentrations of cephalexin, an oral cephalosporin antibiotic which is unique in its absorption and excretion, are reported in human volunteers, fasting, non-fasting and non-fasting plus probenecid. Accumulation does not seem to occur.2. Cephalexin clearance was 376 ml./min and the ratio of cephalexin/creatinine clearances was 2.6 in one volunteer.3. Cephalexin had no effect on the urinary excretion of leucocytes, red cells or protein.4. The very high rate of absorption giving high serum levels and urine concentrations suggest cephalexin will be a useful antibiotic in susceptible bacterial infections in man.


Carbon tetrachloride metabolism in the rabbit. 1. Carbon tetrachloride was administered by stomach tube to rabbits and its distribution in fat, liver, kidney and muscle studied by gas liquid chromatography, during the next 48 hr.2. Chloroform, hexachloroethane and two unidentified chlorinated metabolites were detected in the tissues.3. Hexachloroethane may arise by dimerization of free trichloromethyl radicals.


Anti-inflammatory activity of the steroid alkaloid glycoside, toatine. 1. Tomatine, isolated from extracts of crown gall-infected tomato plants or obtained commercially, was tested for anti-inflammatory activity using three different methods.2. Tomatine administered to intact rats intramuscularly in a dose range of 1-10 mg/kg or orally in doses of 15-30 mg/kg exerted a significant dose dependent inhibition of carrageenan induced paw oedema. The inhibitory effect of tomatine when given in a dose of 10 mg/kg intramuscularly to intact rats lasted more than 24 hr.3. In adrenalectomized rats significant dose-related inhibition of paw oedema was obtained with tomatine and the inhibition at each dose level (0.5-10 mg/kg) was found to be greater than that found in intact animals.4. Tomatine administered subcutaneously to intact rats daily for 7 days in doses of 5 or 10 mg/kg exerted a significant, dose dependent inhibition of granulation tissue formation induced by the subcutaneous implantation of carrageenan impregnated cotton pellets.5. Tomatine administered to intact mice in a dose of 10 mg/kg subcutaneously 1 hr before the intraperitoneal injection of acidified saline and intravenous pontamine sky blue significantly decreased the leakage of the protein bound dye into the peritoneal cavity.6. Tomatidine, the aglycone of tomatine, was not effective at dose levels of 10-20 mg/kg in any of the three tests.


Immunopathologic mechanisms. II. Allergic phenomena mediated by cells.


The cross-reaction of group A streptococci with heart tissue and its relation to induced autoimmunity in rheumatic fever.


Nurses' notes.

Nurses' notes.


Intravesical knotting of a plastic tube introduced per urethram.


Toxic epidermal necrolysis.

Toxic epidermal necrolysis.


Management of trauma.

Management of trauma.


Study of genetics, physiology, pathology and ecology of the Eskimo.


Antepartum identification of the fetus at risk.


Histidinemia: report of four new cases in one family and the effect of low-Histidine diets.


Respiratory insufficiency in acute myocardial infarction. Arterial blood gases and pH were assessed in 115 patients who had suffered a myocardial infarction, with or without complicating cardiogenic shock or cardiac standstill. In 11 of the 78 uncomplicated cases and in 16 of the 37 complicated cases, the arterial O(2) tension was much lower than would be expected on the basis of a three-fold drop in cardiac output, indicating considerable right to left shunting. The death rate in the patients with uncomplicated myocardial infarction was 32% and that of the complicated cases 65%. In both groups it was greatest when the arterial pH was low, indicating that correction of the acidosis is essential. In many instances administration of 100% oxygen is inadequate to restore the oxygen tension to normal levels, and controlled ventilation may be necessary to maintain adequate alveolar ventilation. The findings indicate the necessity for repeated assessment of the arterial blood gas tensions and pH in any patient who has suffered a myocardial infarction. If the management of such patients is designed to provide adequate oxygenation, to maintain adequate alveolar ventilation and to correct the acid-base disturbances, the patient may be tided over the stage of "cardiac pump failure".


Acquired esophagobronchial fistulas in adults.


Auxiliary manpower.

Auxiliary manpower.


Trichinosis: thiabendazole in the treatment of 11 cases. We have studied 11 cases of acute human trichinosis; five of these patients were treated with thiabendazole. We have reviewed the laboratory data for these patients and described their course. This study has failed to show any definite effect of thiabendazole on the course of human trichinosis at the doses used. However, thiabendazole may have decreased the infectivity of the larvae which were embedded in the muscles of our patients.


Mitral regurgitation occurring during methsergide (Sansert) therapy. The case history of a young woman who developed severe mitral regurgitation after four years of methysergide therapy is reported. Replacement of the mitral valve was required. A brief review of the toxic effects of methysergide is given and special reference is made to lesions of the heart valves that have occurred during methysergide therapy.


Bilateral hernias in the female.

Bilateral hernias in the female. An experience with 216 bilateral hernias in female patients is reviewed. The condition is rare, occurring only once in every 250 patients admitted for a hernia repair. Bilateral primary indirect inguinal hernias were the most frequent type. Bilateral primary femoral hernias were quite rare while bilateral primary direct inguinal hernias were even more uncommon. Other rare bilateral combinations are briefly described. The incidence in children is given.Etiological factors are discussed, emphasizing the strong posterior wall of the inguinal canal in females.Two per cent of patients developed a recurrent hernia; one per cent of hernias recurred. No recurrence following a bilateral primary indirect inguinal hernia repair and no "femoral" recurrence following inguinal repair were recorded.


Use of a hospital emergency service by children and adolescents for primary care. This study was planned to determine the extent to which the emergency service of a large general hospital in Vancouver was providing a primary medical care function for children and adolescents. The data were collected during 14-day study periods in each season of the year. Medical data and physician urgency rating were obtained on all patients. Demographic and socioeconomic data and data pertaining to patterns of medical care were obtained by interview of a one-third sample.The study identified a group of patients receiving primary medical care for non-urgent and non-traumatic conditions. This group resided close to the hospital and had lower socioeconomic indices than the remainder of the patients.The trend to utilize the emergency department for reasons other than the accident and emergency function was confirmed. These findings will be incorporated in the planning of the New Children's Hospital in Vancouver with the provision of separate facilities for the care of non-urgent attenders.


Effect of histalog, insulin and reserpine on gastric emptying and secretion in man. Four different groups of subjects were given Histalog, insulin or reserpine or acted as controls. Changes were noted in gastric emptying, acid, chloride, parietal and non-parietal secretions and neutral chloride. Gastric emptying and secretion were measured by the Hunt and Spurrell test meal as modified by us for drug testing.Histalog stimulated gastric secretion but not emptying. Insulin stimulated both secretion and emptying. Reserpine stimulated secretion but it stimulated emptying only in one-half of the subjects.After Histalog and reserpine the rise in hydrogen and chloride secretion was equal, so the neutral chloride did not increase. After insulin the rise of chloride was proportionately greater than the rise of hydrogen, so that neutral chloride was increased.


Fractured humerus.

Fractured humerus.


In Canada: a trial of chemoprophylaxis in inactive tuberculosis. One thousand five hundred and thirty-six patients with inactive tuberculosis were given a course of preventive treatment consisting of either INH alone or INH and PAS while 840 similar patients served as a control group. Discontinuation of the treatment was frequent and was usually caused by development of complaints which the patients ascribed to the drugs they were taking.The annual reactivation rate among controls was 4.9 per 1000. During the period of taking drugs the treated group suffered a reactivation rate of 0.7 per 1000 and those who had taken the medication for at least six months suffered a subsequent annual reactivation rate of 1.3 per 1000. The rate for those who discontinued treatment in the first six months was 5.1 per 1000. There were no reactivations in patients who took INH and PAS for over six months. Bacilli from two of the patients with reactivations who were treated for a prolonged period with INH alone showed resistance to this drug.Chemoprophylaxis of inactive cases is a potent weapon in tuberculosis control; however, it requires thorough motivation and supervision.


Ontario's Medicare plan.

Ontario's Medicare plan.


Battered babies.

Battered babies.


Chemical mediators of the vascular phenomena of acute inflammation.


Canadian psychiatry: a problem of priorities.


The mutative impact on family life of serious mental and physical illness in a patient.


Characteristics of university students with emotional problems.


The dilemma with aggression: primary need or consequence of frustration.


The therapeutic contract with adolescents.


Doctor and Mrs.--their mental health.

Doctor and Mrs.--their mental health.


Phenothiazine treatment and electrocardiographic abnormalities.


Determination of serum albumin on the SMA-12/30 (hospital model) using bromo-cresol green.


Bilirubin and the polarographic Brdicka reaction.


Two-dimensional paper chromatographic determination of amino acids in urine.


Application of a continuous spectrophotometric assay for 5'nucleotidase activity in normal subjects and patients with liver and bone disease.


Fluorometric screening procedure for galactosemia utilizing the autoanalyzer.


A fluorometric method for plasma cortisol and transcortin.


The estimation of magnesium in plasma, muscle and bone, by atomic absorption spectrophotometry.


Effects of starvation on plasma pancreatic glucagon in normal man.


Measurement of bisulfite in biologic solutions.


Antagonism between the effects of insulin and glucagon on the isolated liver.


A rat pancreas-small gut preparation for the study of intestinal factor(s) and insulin release.


Zinc glucagon depression of blood amino acids in rabbits.


Immunoreactive insulin, glucose tolerance, and carbohydrate inducibility in types II, 3, IV, and V hyperlipoproteinemia.


Relation of the course of retinopathy to control of diabetes, age, and therapeutic agents in diabetic Japanese patients.


Vesical stones due to a foreign body.

Vesical stones due to a foreign body.


Juvenile delinquency in Uganda, East Africa.


Anaesthetic technique for cerebral angiography.


Convulsive disorders in Nigerians: the febrile convulsions. (An evalugtion of 155 patients).


Isolation of erysodine, erysotrine and hypaphorine from Erythrina suberosa Roxb. seeds.


Central depressant properties of 3,1-benzoxazine derivates.


Synthesis of (+-)-isoelliptone.

Synthesis of (+-)-isoelliptone.


New creatine kinase isoenzymes in birds. Distribution among avian orders, tissue-specific patterns and their appearance in ontogeny.


Hepatic DNA synthesis after partial hepatectomy in rats treated with protamin-Zn-insulin under different nutritional conditions.


Creatine of mouse brain: evidence of active uptake from blood.


Metabolism of metopirone and 3-(1,2,3,4-tetrahydro-1-oxo-2 naphthyl)-pyridine in relation to DMBA induced adrenal necrosis.


Difference in iron release by alpha-ferritin and beta-ferritin.


Nucleic acid, amino acid and carbohydrate metabolism of nurse cell nucleoli in Musca domestica.


Colorimetric method for measuring pseudocholinesterase, acetylcholinesterase and whole blood cholinesterase. Its use in the presumptive diagnosis of cancer.


On the dependence of nuclear oxidative phosphorylation on glycolysis in isolated rat thymus nuclei.


The transport capacity for bilirubin in rat liver and its relation to bile flow.


The urinary excretion of bilirubin after increased plasma hemoglobin concentration in dogs.


Liver cell necrosis in rats after prolonged ethanol ingestion under the influence of an alcohol-dehydrogenase inhibitor.


Respiratory responses of the conscious dog to severe heat stress.


After-potentials due to an electrogenic pump in molluscan giant neurons.


Preparation of 'new'-vasoconstrictine (SVPx), a vasoconstrictor hormone of plasma.


Activity and isolated phytoestrogen of shrub palmetto fruits (Serenoa repens Small), a new estrogenic plant.


Transmission of Rauscher leukemia in mice.


The technic x-ray histochemistry applied to neurohistology.


Innervation of pulmonary capillaries.

Innervation of pulmonary capillaries.


Cell proliferations in Lymantria dispar L. larvae infected with the nuclear polyhedrosis virus.


An electron microscopical demonstration of the permeability of cerebral and retinal capillaries to ions.


The quantitative estimation of the changes induced by benzydamine in the mitochondria of developing mouse hepatocytes.


Effect of furosemide on aminopeptidase activity in the rat kidney and urine.


Direct histochemical demonstration of histamine in cutaneous mast cells: urticaria pigmentosa and keloids.


The effect of monamine synthesis inhibitors on the ovarian compensatory hypertrophy.


Accumulation of 5-hydroxydopamine in 5-HT storage organelles of cat platelets and concomitant changes in platelet aggregation.


The effect of radiothroidectomy on blood volume, red cell survival and iron kinetics in puppies.


Chromosomes of the Asian chipmunk Eutamias sibiricus Laxmann (Rodentia: Sciuridae).


Chromosomes of the rock hyrax, Procavia capensis (Pallas), 1767.


XY females caused by x-irradiation.

XY females caused by x-irradiation.


Amino acids as stimulating agents of DNA replication in melanomas. I. Stimulation in explants.


In vitro metabolism of progesterone by the adrenals of spontaneously hypertensive rats.


Evolution of nucleic acids and proteins in the course of regeneration in an oligochaete (Aulophorus furcatus).


A new agent for the treatment of liver fluke infection (fascioliasis).


Effect of injury on the foliar sclereid development in Fagraea fragrans.


Medio-lateral distribution of inductive capacity in the organizer of the frog, Rana cyanophlyctis.


Intracellular location of hyphae in experimental dermatomycosis.


New alkaloids from Murraya koenigii Spreng.


Crepitin, a phytohemagglutinin from Hura crepitans.


Rivanol-ethanol fractionation of parotid fluid and colostrum.


'Intermittent chemotherapy' in intracardially infected tuberculous guinea pigs.


AVMA's educational kinescopes.

AVMA's educational kinescopes.


Loss of protein in the sputum. A study of 50 cases.


Is protein malnutrition an initiating cause of pancreatic calcification?


Drug interaction--a potential hazard in clinical practice.


Tween 80 therapy in tropical sprue.

Tween 80 therapy in tropical sprue.


Amoebic liver abscess with radiological demonstration of rupture into biliary tract. (A rare entity--case report and review of literature).


Haemangiomatus splenomegaly.

Haemangiomatus splenomegaly.


Idiopathic arteritis of aorta and pulmonary artery.


Multiple myeloma.

Multiple myeloma.


Regulation of the TCA and glyoxylate cycles in Brevibacterium flavum. II. Regulation of phosphoenolpyruvate carboxylase and pyruvate kinase.


Role of cholesterol esterifying enzyme present in the soluble cell fraction of rat liver.


Isolation and characterization of the antigenically distinct proteinpolysaccharide complex from uman aorta.


Identification of methylated beta-alanylhistidine in the muscles of snake and dolphin.


Purification and crystallization of ribonuclease N1 from Neurospora crassa.


Interaction of uridine-2'(3'),5'-diphosphate withibonuclease A and carboxymethylribonuclease A.


Inhibitory effects of mycotoxins on the protein synthesis in rabbit reticulocytes.


Tyrosine, histidineand tryptophan residues in TPCK-modifiechymotrypsin.


Optical absorption and circular dichroism of egg white flavoprotein.


Studies on the biosynthesis in vitro of parathyroid hormone. I. Synthesis of parathyroid hormone by bovine-parathyroid gland slices and its control by calcium.


Characterization of steroid-binding sites by affinity-labeling. II. Biological activity of 4-mercuri-17 beta-estradiol.


5 Alpha-cholest-8(14)-en-3 beta-ol, a possible intermediate in the biosynthesis of cholesterol. Enzymatic conversion to cholesterol and isolation from rat skin.


Oligosaccharides of human milk. II. Isolation and characterization of a new pentasaccharide, lacto-N-fucopentaose 3.


The complex nature of proelastase, a propeptidase, and associated protein.


Partial purification and kinetic properties of a soluble estrogen glucuronyltransferase from pig intestine.


The chemistry and molecular architecture of the cell walls of Penicillium chrysogenum.


The role of the adrenals in the regulation of phosphoenolpyruvate carboxykinase of rat adipose tissue.


Ribosomal ribonucleic acid wastage in resting and growing lymphocytes.


Analysis of amino acid phenylthiohydantoins by gas chromatography.


Early effect of thyroxine in vi on rapidly labeled mitochondrial protein fractions and respiratory control.


The 220 MHz nuclear magnetic resonance study of a solvent-induced conformational change in flavin adenine dinucleotide.


Uridine diphosphate glucose pyrophosphorylase. II.


Metabolic interrelations of sulfur in proteins, thiosulfate, and cystine.


Streptococcal proteinase-catalyzed hydrolysis of some ester and amide substrates.


Residues of Gardona in the body tissues and eggs of laying hens exposed to treated litter and dust boxes for control of external arthropod parasites.


Some hydroxynitrosamino aliphatic acid derivatives as insect reproduction inhibitors.


Demethylation of the insecticide bromophos by a glutathione-dependent liver enzyme and by alkaline buffers.


Toxicity of DDT, carbaryl, and azinphosmethyl to gamma-radiated pink bollworm moths.


Relationship between structure of several Azodrin insecticide homologues an their toxicities to house flies, tested by injection, infusion, topical application, and spray methods with and without synergist.


Control of southern house mosquito larvae in Louisiana papermill log ponds.


Genetic control of house fly NADPH-dependent oxidases: relation to insecticide chemical metabolism and resistance.


Yellow jacket control by baiting. 1. Influence of toxicants and attractants on bait acceptance.


Sterilization of boll weevils with combinations of chemosterilants and x-rays, gamma rays, thermal neutrons, or fast neutrons.


Experimental control of the northern fowl mite.


Metabolism of fenthion by the southern house mosquito.


Radioautographic study of the diffusion of topically applied DDT-C14 into the house fly and its distribution in internal organs.


An ultrastructural and cytological study of preimplantation development of the mouse.


Effect of actinomycin D on antigen synthesis during sea urchin development.


The ar of the chameleon. Chamaeleo höhnelii and Chamaeleo jacksoni.


Amylase variants in Drosophila melanogaster: linkage studies and characterization of enzyme extracts.


The physician's assistant. One approach to the medical manpower problem.


An ultrastructural study of lens invagination in the mouse.


The future of medical care. How will it be affected by the public's demands and reactions?


The effect of teratogenic doses of trypan blue on the yolk sac placenta of the mouse. A histological and histochemical study.


Antacids.

Antacids.


Hypotension and the shock syndrome in myocardial infarction.


Rubella vaccine recommendations.

Rubella vaccine recommendations.


Epidemiology and occupational medicine.

Epidemiology and occupational medicine.


Expanding horizons for occupational medicine.


Percutaneous absorption of lead from industrial lubricants.


A survey of fire prevention problems in closed oxygen-containing environments.


Arsine intoxication in a chemical plant. Report of three cases.


Exercise and health education.

Exercise and health education.


Mobile multiphasic screening in an industrial setting.


Mobile multiphasic screening in an industrial setting. The California cannery workers program.


Limitations on prebiological synthesis.

Limitations on prebiological synthesis.


Pericardial tamponade following open-heart surgery.


Primary dysmenorrhoea.

Primary dysmenorrhoea.


Smoking and health: some curious comments.


Fifteen cases of pleural mesothelioma associated with occupational exposure to asbestos in Victoria.


Carbenicillin therapy in renal failure.

Carbenicillin therapy in renal failure.


Transformations and the understanding of sentences.


On the complex regulating the voiced-voiceless distinction. II.


The use of "Catapres" in the treatment of severe hypertension.


Some critical comments on visual presentation in word matching studies of phonetic symbolism.


Vitamin B12 absorption studies: comparison of 57CO vitamin B12 plasma levels with and without parenteral vitamin B12.


The Lesch-Nyhan syndrome.

The Lesch-Nyhan syndrome.


Effects of delayed sidetone on the speech of aphasic, dysarthric, and mentally retarded subjects.


Replanning Sydney Hospital. 2. The socio-technical balance in hospital management.


Ischaemic colitis.

Ischaemic colitis.


"Mediterranean guts ache".

"Mediterranean guts ache".


An endoscopic view of the British Health Service.


Health insurance.

Health insurance.


Dialect and identification in persuasive messages.


Banning of products containing halogenated salicylanilides.


Drug dependence--challenge and response.


Rate alterations in oral reading.

Rate alterations in oral reading.


Experimentally-elicted articulatory behaviour.


Maternal Welfare Committee Report for 1968.


New duties and responsibilities assigned to the Missouri State Surgical Society.


Perforated idiopathic cecal ulcer in a 12-year-old diabetic patient. Case report.


Phenolic cauterization of the matrix in the surgical cure of ingrown toenails.


Virilization associated with cystic granulosa tumors.


Risk of premature delivery among indigent Negro women based on past reproductive performance.


Ovarian lutein cysts associated with an otherwise normal pregnancy. Report of a case.


Pregnancy after bilateral ligation of the internal iliac and ovarian arteries.


Pregnancy complicated by urinary tract infections.


Prognosis of endometrial carcinoma.

Prognosis of endometrial carcinoma.


Factors influencing the high incidence of grand multiparity in Trinidad and Tobago.


The safety of multiple cesarean sections.


Safety studies with ultrasonic Doppler technic. A clinical follow-up of patients and tissue culture study.


Prenatal sex ratio in man. Observations contradictory to the prevailing concept.


Time for reconciliation and adjustment.

Time for reconciliation and adjustment.


The Frankfort Technic of suprapubic bladder drainage.


Desulfation of L-serine O-sulfate in ligated rat liver lobes.


Effects of changes in extracellular K+ concentration on resting and action potentials of the toad spinal motoneuron.


Laboratory studies on the lead poisoning in six cases with lead shot lodged in the tissues.


The persistence of Mycoplasma mycoides in the host after vaccination with T1 broth vaccine.


Inhibition of Ostertagia ostertagi at the early fourth larval stage. I. The seasonal incidence.


Cerebral apoplexy and systemic arterial pressure: a clinical contribution.


Inhibition of Ostertagia ostertagi at the early fourth larval stage. II. The influence of environment on host or parasite.


An approach to quantitative analysis of dermatoglyphics by digital computer.


Acid-base and blood gas studies in horses. I. A comparison of capillary and arterial blood samples for the estimation of acid-base values in horses.


The organization of air transport services for sick and injured persons, particularly road accident victims.


Acid-base and blood gas studies in horses. II. Tracheal end-tidal and arterial blood gas tensions in horses.


Candidosis and candidids.

Candidosis and candidids.


The carriage of immature and cardiopathic children in airliners.


Leukopheresis in calves and dogs by extracorporeal circulation of blood through siliconized glass wool.


The filament-containing cell in the bovine abomasum.


Harlem's addict center.

Harlem's addict center.


Growth curves in pig kidney cels of three porcine adenoviruses.


The inactivation of Erysipelothrix rhuopathiae in macrophages from normal and immune mice.


Consumer involvement in rehabilitation.

Consumer involvement in rehabilitation.


The basics of rehabilitation funding.

The basics of rehabilitation funding.


Excision of the internal iliac arterial system and uretero-vesical ischaemia. An experimental investigation.


The delivery of rehabilitation services.


A photoelectric technique for the detection of vasomotor changes in the skin of the pig.


Haemoglobin types in some Nigerian goat breeds.


Summary of a happening.

Summary of a happening.


Labelling of the rat thymus by intramediastinal injection of tritiated thymidine.


Abnormal carbohydrate metabolism in bronchogenic carcinoma.


Misalignment sensing applied to monitoring of angular deflection.


Nutritional folate deficiency in the United Kingdom.


Problems of an electrocardiogram reporting service.


Radiodiagnosis tutorial. The pelvis.

Radiodiagnosis tutorial. The pelvis.


Mycoplasma pneumoniae. One year's experience in an urban practice.


The unit system. A new approach in state hospital care.


Nucleolar 'cap' formation and carcinogenicity in 4-nitroquinoline-1-oxide and related compounds.


Diagnosis of surgically remediable hypertension.


A new tub for burn wound care.

A new tub for burn wound care.


Hypertension in the young athlete.

Hypertension in the young athlete.


Clinicopathologic conference.

Clinicopathologic conference.


Lung cancer in Finland and Norway: an epidemiological study.


Degenerative changes in the proximal renal tubules following administration of bacitracin. An ultrastructural study in the mouse.


Hearing acuity and exposure to patrol aircraft noise.


The professional preparation of dormitory counselors for schools for the deaf.


The grammar of the noun phrase and arithmetic instruction for deaf children.


The prelingual deaf child and his oral education in a new perspective.


An investigation of visual-sequential memory in deaf children.


The education of deaf children in England.


Critique on current auditory training equipment.


Prolongation of isovolumic contraction time in left bundle branch block.


Acute hemodynamic effects of ethanol on normal human volunteers.


Clinical, hemodynamic, and surgical considerations of rupture of the ventricular septum after myocardial infarction.


Simulation of atrial flutter by rapid coronary sinus pacing.


Absolute hemodilution cardiopulmonary bypass: free water distribution and protein mobilization in body compartments.


Sudden death in congenital aortic stenosis. A review of eight cases with an evaluation of premonitory clinical features.


Effects of glucagon on myocardial contractility and hemodynamics in acute experimental myocardial infarction. Basis for its possible use in cardiogenic shock.


Alternate deletion and potentiation as the cause of pulsus alternans.


Coronary embolism in primary myocardial disease.


Transvenous cardiac pacemaker, mural thrombosis, and pulmonary embolism.


Geriatric cardiology.

Geriatric cardiology.


Pathophysiology and treatment of orthostatic hypotension.


Assessment of the immediate prognosis during acute myocardial infarction.


Estrogens and puerperal thrombembolism.

Estrogens and puerperal thrombembolism.


The hemagglutinating properties of an antiserum to erythropoietin.


The infectious mononucleosis cells.

The infectious mononucleosis cells.


The wage and hour law as it affects medical technologists.


Vocational interests of pre-medical technology students.


A look at the new curriculum design.

A look at the new curriculum design.


Timely topics in clinical chemistry: toxicology and trace metals II.


Treatment of uterine adhesions (Asherman's syndrome).


Results of treatment of invasive cancer of the cervix uteri.


Milk-ejecting and antidiuretic activities under neurohypophyseal inhibition with alcohol and water overload.


Pituitary growth hormone and placental lactogen levels measured in normal term pregnancy and at the early and late postpartum periods.


Oxytocic and modulating effects of water-soluble hydrocortisone and methylprednisolone upon in vitro contractions of myometrium.


Quantitative study of the regularity of uterine contractile rhythm in labor.


Free amino acids in the pregnant uterus.


Nontoxemic hypertension in pregnancy in the African indigene. An analysis of 30 cases.


Classification of fetal heart rate in relation to fetal scalp blood measurements and Apgar score.


Autonomic control of fetal heart rate.

Autonomic control of fetal heart rate.


Oxygen administration during labor.

Oxygen administration during labor.


Evaluation of chemical pregnancy tests based upon the presence of magnesium.


Continuous saline flushing--a modification for vacuum evacuation of the uterus.


Occult fetal-maternal transfusion.

Occult fetal-maternal transfusion.


Clinical, biochemical, and experimental studies on lactation. 3. Biochemical changes induced in human milk by gestagens.


Confrontation at Ortho 1969.

Confrontation at Ortho 1969.


The paraprofessional and the use of confrontation in the mental health field.


Teachers and differences.

Teachers and differences.


Use of day treatment center concepts with state hospital inpatients.


Biological and social correlates of stature among children in the slums of Lima, Peru.


Followup evaluation of family crisis therapy.


Five years later: a followup study of compehensive vocationally oriented pyschotherapy.


Alcoholism: methodological consideration in the study of family illness.


Factors affecting the outcome of child psychiatric consultations.


Parental loss and some characteristics of the early marriage relationship.


The social awareness of autistic children.


Mental health and the urban crisis.

Mental health and the urban crisis.


Our place: design for a day program.

Our place: design for a day program.


Sex differences in the growth of the human bony pelvis.


Hair patterns of the pinna of white and Negro males.


The basal area of posterior tooth crown components: the assessment of within tooth variations of premolars and molars.


Ponderal index and height.

Ponderal index and height.


Evidence of X-linkage of tibial length and body length.


The relationship of weathering cracks to split-line orientation in bone.


Dentition of Bedouin in Israel. II. Morphology.


A method for assessment of maximum long bone length and living stature from fragmentary long bones.


Rapid changes in weight and growth potential during childhood.


Electronic methods for the analysis of the human post-canine dentition.


Scientific ethics and physical anthropology.


On the significance of studying the anal reflex in some proctologic diseases.


Complications after radical operations for cancer of the rectum and colon.


Punch biopsy of tumors of the rectum and pararectal area.


Electrolytes and intestinal diseases.

Electrolytes and intestinal diseases.


Carcinoma of the colon and rectum. The author's own observations.


Proctology and the general practitioner.


The meeting of the inner and the external world: in schizophrenia, everyday life and creativity.


Idle hands and giddy minds; our psychological and emotional unpreparedness for free time.


What is technique?

What is technique?


The use of existential-philosophic concepts in psychotherapy.


Character problems and their relationship to drug abuse.


The adoration of the patient and its disillusionment.


Electrochemical study of ubiquinone-6 in aqueous methanol.


Investigation of a learning block in a schizophrenic.


Intravenous thiobarbiturate anesthesia for cesarean section.


The effects of halothane on arterial pressure, preganglionic sympathetic activity and barostatic reflexes.


The effects of methoxyflurane on arterial pressure, preganglionic sympathetic activity and barostatic reflexes.


The effects of germine diacetate on the rat phrenic nerve--diaphragm preparation.


The effects of substrates on contractility of rat atria depressed with halothane.


Facilitated transfer of halothane in human erythrocytes.


Application of low-temperature autoradiography to studies of the uptake and metabolism of volatile anesthetics in the mouse. 3. Halothane.


Innovar as a supplement to regional anesthesia.


Metabolism of halothane-2 14C in the mouse.


Effect of anatomic shunt on physiologic deadspace-to-tidal volume ratio--a new equation.


An "immobile needle" for nerve blocks.

An "immobile needle" for nerve blocks.


Digitalis and heart disease.

Digitalis and heart disease.


Color perception in unilateral aphakia.

Color perception in unilateral aphakia.


Clinical features of superior limbic keroconjunctivitis in Australia. A probable association withhyrotoxicosis.


The peripheral eyeground in hronic respiratory disease.


Zonular traction tufts o the peripheral retina in cadaver eyes.


True exfoliation of the lens cpsule. An electron microscop study.


A diagnostic probe for intraocular lesions.


Effect of osmotic agents on the vitreous body.


Lester's line in hereditary osteo-onychoysplasia.


Peripapillary staphyloma.

Peripapillary staphyloma.


Effect of cerebral damage on motivation in rehabilitation.


Public school speech and hearing programs: things are changing.


Immunoelectrophoretic analysis of proteins in lymph from the leg before and after thermal injury.


Incorporation of (2-14C, (5r)-5-3H1) mevalonic acid into cholesterol by a rat liver homogenate and into beta-sitosterol and 28-isofucosterol by larix decidua leaves. 1. Incubation of a rat liver homogenate with 3R-[2-(14)C,(5R)-5-(3)H(1)]mevalonic acid gave cholesterol with (3)H/(14)C atomic ratio 6:5. 2. Conversion of the labelled cholesterol into 3beta-acetoxy-6-nitrocholest-5-ene or cholest-4-ene-3,6-dione resulted in the loss of one tritium atom from C-6. 3. These results show that during cholesterol biosynthesis the 6alpha-hydrogen atom of a precursor sterol is eliminated during formation of the C-5-C-6 double bond. 4. Incorporation of 3R-[2-(14)C,(5R)-5-(3)H(1)]mevalonic acid into the sterols of larch (Larix decidua) leaves gave labelled cycloartenol and beta-sitosterol with (3)H/(14)C atomic ratios 6:6 and 6:5 respectively. 5. One tritium atom was lost from C-6 on conversion of the labelled beta-sitosterol into either 3beta-acetoxy-6-nitrostigmast-5-ene or stigmast-4-ene-3,6-dione, demonstrating that formation of the C-5-C-6 double bond of phytosterols also involves the elimination of the 6alpha-hydrogen atom of a precursor sterol. 6. The 3R-[2-(14)C,(5R)-5-(3)H(1)]mevalonic acid was also incorporated by larch (L. decidua) leaves into a sterol that co-chromatographed with 28-isofucosterol. Confirmation that the radioactivity was associated with 28-isofucosterol was obtained by co-crystallization with carrier 28-isofucosterol and ozonolysis of the acetate to give radioactively labelled 24-oxocholesteryl acetate. 7. The significance of these results to phytosterol biosynthesis is discussed.


Type of response to steady illumination and level of neuronal dark discharge in the central visual pathways.


The effect of cerebral ischeaemia or intracarotid injection of methohexitone on short term memory in goats.


Progressive changes in auditory response patterns to repeated tone during normal wakefulness and paralysis.


Tone-burst response patterns of single units in the cat medial geniculate body.


Histochemical localization of cholinesterases in the cochlear nuclei of the cat, with notes on the origin of acetylcholinesterase-positive afferents and the superior olive.


Comparative enzyme histochemical observations on submammalian brains. 3. Hippocampal formation in reptiles.


Energy dependence of amino acid uptake in brain slices.


Uptake of corticosterone by rat brain and its concentration by certain limbic structures.


Splanchnic projection to the orbital cortex of the cat.


Genetic variability in forebrain structures between inbred strains of mice.


Spontaneous and evoked oscillations in respiratory and sympathetic discharge.


Carotid sinus nerve: primary afferent depolarization evoked by hypothalamic stimulation.


Estimation of errors in conduction velocity measurements due to branching of peripheral nerve fibers.


Persistence of post-synaptic membrane thickenings after degeneration of olfactory nerves.


Insight deficit after neonatal fornicotomy or laterodorsalis thalamotomy in rats.


Pupil response to light and electrical stimulation: static and dynamic characteristics.


Effects of glycine, beta-alanine and GABA, and their interaction with strychnine, on brain stem neurones.


Lyasergic acid diethylamide: antagonism of supraspinal inhibition of spinal reflexes.


Further studies on the origin of corticospinal fibres in the cat. An experimental study with the Nauta method.


Localization in caudal brain stem and cervical spinal cord of neurones activated from forelimb group I afferents in the cat.


Experimental anatomical demonstration of a cortico-olivary projection from area 6 (supplementary motor area?) in the cat.


Relationships between foraging efficiency and the size of the head and component brain and sensory structures in the red wood ant.


Surgical management of the neurogenic bladder and its complications.


Sedation for conervative dentistry.

Sedation for conervative dentistry.


The clinical presentation of ectopic thyroid gland with results of radioiodine studies.


Eosinophilic meningitis in Hodgkin's disease.


A case of encephalitis with high pyrexia treated with hypothermia.


Spontaneous fracture of the sternum simulating pulmonary embolism.


Malignant retroperitonel fibrosis presenting as a vascular emergency.


Metabolic bone disease.

Metabolic bone disease.


Allergic reactions: following patent blue dye injection.


Human behaviour in disaster.

Human behaviour in disaster.


At the Montreal General Hospital: extension injury to the cervical spine (case P25).


Improvement in laboratory diagnosis of pulmonary cryptococcosis. A new differential colour medium prepared with an extract of potatoes and carrots produced ochre-brown pigmentation in Cryptococcus neoformans colonies, identical to that obtained with Guizotia abyssinica seed extract. The pigment formation was observed to be specific for this pathogenic yeast in a survey of 534 yeast-positive specimens during routine diagnostic work; among 47 C. neoformans-positive specimens were 27 sputa and bronchial aspirations, many overgrown by common yeasts.Detection of C. neoformans in the contaminated specimens was credited largely to the differential medium used. Twelve cases of cryptococcosis were investigated between 1962 and 1968, five of which presented involvement of the respiratory tract only.


Treatment of hypertension with hydrochlorothiazide and spironolactone. A comparison was made of the antihypertensive effect of a daily dose of 150 mg. of hydrochlorothiazide (HCT) with one of 150 mg. of spironolactone (SL) in 48 patients with essential hypertension.The blood pressure values after six weeks of therapy with HCT were not significantly different from those after SL. Treatment of 25 of these patients with the two agents combined did not reduce the blood pressure further. Blood urea nitrogen concentrations increased with both HCT and SL treatment.With combined treatment there was a further increase in blood urea nitrogen concentration and a decrease in serum sodium concentrations without weight loss beyond that achieved with either HCT or SL alone.


Serum and urine osmolality in normal full-term infants. Serum and urine osmolalities were measured for the first five days of life in healthy fullterm newborns fed from the first day. Values of serum osmolality were found to be lower than in previous studies of newborns and lower than those of children and adults. The early initiation of feeding, the low solute concentration of the formula and the relatively low glomerular filtration rate of newborns may account for these observations. A rise in serum osmolality concurrent with the elaboration of a more dilute urine suggests that maturation of mechanisms involved in water excretion occurs in the first five days of life.


Undergraduate clinical education.

Undergraduate clinical education.


New approaches to health problems of the Indian and Eskimo people.


Classification of disease in general practice: a comparative study. A comparison is made between the International Classification of Diseases (Eighth Revision) and the classification of the British College of General Practitioners (1963 Revision), with particular reference to their application to the diagnostic data from a family practice in Canada over a period of one year. The International Classification proves superior but would require modification to be ideal for use in recording morbidity from general practice. A plan for such a modification is outlined.


Myasthenia gravis: comparative evaluation of medical and surgical treatment. Sixty-eight patients with myasthenia gravis were evaluated and compared to determine the results of medical and surgical treatment; eight patients with thymoma were evaluated separately. In the group of 30 non-thymoma patients treated medically 50% of patients derived moderate to good improvement over a mean follow-up period of 11 years. Ten per cent of patients in this group died from myasthenia.In the group of 30 non-thymoma patients treated by thymectomy, 83% achieved good to excellent improvement. There was no surgical or myasthenic mortality over a mean follow-up period of nine years.The results of treatment in the eight thymoma patients were decidedly inferior and there was no significant difference between the medically and surgically treated patients. Fifty per cent showed only moderate improvement during a mean follow-up of five years and 50%, after initial improvement, deteriorated later and died from myasthenia between three and four years after thymectomy.Two additional patients had thymoma without myasthenia. Neither of them had developed myasthenia, two years following thymectomy in one case and after 25 years in the other, despite recurrence of the tumour with extensive invasiveness in the very long-standing case.


Acute cholecystis following unrelated surgery. In a series of 26 cases of acute cholecystitis occurring after an operation for an unrelated condition, 88% of the patients were over 50 years of age and males outnumbered females by 2 to 1. In some of the cases diagnosis was difficult and delay was responsible for the death of one patient. Acalculous cholecystitis occurred in 20% of the cases and in these gangrene or perforation supervened early in the course of the disease.Efforts should be directed to ensuring adequate hydration after operation; resumption of a diet low in fat may be important. Even in the absence of a history of biliary disease, there is a place for the radiological study of the biliary tract before major elective operations are performed. If gallstones are discovered on the occasion of the initial surgery, cholecystectomy should be performed whenever it is feasible. In any patient with postoperative cholecystitis early operation is generally indicated.


The relationship of Budd-Chiari syndrome to oral contraceptives and trauma.


It's time Ottawa legislated against a deadly habit.


Studies on hypoglycemic agents. V. A new synthetic method for sulfonylurea derivatives.


Studies on the biological activity. II. Discussions on the biological activity of para- and meta-substituted benzene derivatives.


Inhibition of tryptophan pyrrolase of rats by phenols, tryptophan analogs and hydrazine derivatives.


Antagonistic phenomena between crystalline tetrodotoxin and guanidines on sympathetic nervous systems.


Studies on steroid conjugates. II. Synthesis of 16-epiestriol monoglucuronides.


Absorption and excretion of drugs. XL. Enhancement of the rectal absorption of pharmaceutical amines with lauryl sulfate and saccharinate anions.


Synthesis of every kinds of peptide fragments of bradykinin.


Metabolism of drugs. LXIV. Species differences of metabolism of phenacetylurea.


Studies on metabolism of 3-desoxyestrone. 3. Synthesis of 6-oxygenated estra-1,3,5(10)-trienes and related compounds.


Studies on antitumor agents. 3. Metabolites of 5(4)-amino-4(5)-imidazolethiocarboxamide derivatives in urine.


Enhancement of antitumor activity of cyclophosphamide with imipramine.


Case report no. 26830.

Case report no. 26830.


In vivo and in vitro antitumor activity of sugars containing sulfur.


Analysis of 511 open fractures.

Analysis of 511 open fractures.


Principles of psychiatric emergency management.


Intertrochanteric fractures.

Intertrochanteric fractures.


Rational pharmacotherapy.

Rational pharmacotherapy.


Therapeutic punishment in severely disturbed children.


Unique tibial shaft fracture resulting from helicopter crashes.


Lithium in prophylaxis.

Lithium in prophylaxis.


Therapy of non-narcotic psychoactive drug dependence.


Lower-extremity balanced traction. A modification of Russell traction.


Cryptococcosis of bone. Case report and review of the literature.


Electro-suggestive therapy.

Electro-suggestive therapy.


Unilateral electro-convulsive therapy.

Unilateral electro-convulsive therapy.


Collagen and mineral dynamics in bone.

Collagen and mineral dynamics in bone.


LSD-assisted psychotherapy with terminal cancer patients.


Osteotomy of the spine.

Osteotomy of the spine.


Indoklon convulsive therapy; present status.


Biomechanics of cup arthroplasty.

Biomechanics of cup arthroplasty.


The adaptability of vitallium mold arthroplasty to difficult hip problems.


Mental health education for parents.

Mental health education for parents.


Developments in dance therapy.

Developments in dance therapy.


The "adversary" system in married couples' group therapy.


Mold arthroplasty of the knee joint.

Mold arthroplasty of the knee joint.


Task groups in the therapy of mental patients.


The Connecticut Cooperative Care Project.


Emergency room psychiatry.

Emergency room psychiatry.


Perspectives on work therapy.

Perspectives on work therapy.


Outpatient child psychopharmacotherapy.

Outpatient child psychopharmacotherapy.


Family therapy in a private hospitasetting.


Joint admission of mothers and children to a state hospital.


Psychiatric care through home nursing services.


The Monteggia lesion. A review of 159 cases.


Outpatient group therapy of the poor.

Outpatient group therapy of the poor.


Mental health without walls: programs for the ghetto.


Integration of mental health into public health programs.


Community psychiatry in Australia.

Community psychiatry in Australia.


Drugs in child psychotherapy.

Drugs in child psychotherapy.


Progress in health planning: the role of community psychiatry.


Therapies for autistic children.

Therapies for autistic children.


The forensic psychiatry clinic: model for a new approach.


Teacher response to psychiatric consultants in the school.


Federal perspectives  community mental health.


Trends in adolescent psychiatry.

Trends in adolescent psychiatry.


Freedom in analytic therapy.

Freedom in analytic therapy.


Pastoral counseling.

Pastoral counseling.


Brief psychotherapy in physical illness.


Psychotherapy in renal failure.

Psychotherapy in renal failure.


Psychotherapy with prisoners.

Psychotherapy with prisoners.


Climatology and medicine. VII.

Climatology and medicine. VII.


A case of recurrent abruptio placentae.

A case of recurrent abruptio placentae.


Whither tuberculosis?

Whither tuberculosis?


The ups and downs of priapism.

The ups and downs of priapism.


Gram-negative bacillary infection.

Gram-negative bacillary infection.


Breast cancer.

Breast cancer.


Betterment of public health.

Betterment of public health.


Malnutrition and pregnancy.

Malnutrition and pregnancy.


Cell lineage, growth, and determination in the imaginal leg discs of Drosophila melanogaster.


Zoospore germination in the water mold. Blastocladiella emersonii. I. Measurement of germination and sequence of subcellular morphological changes.


Zoospore germination in the water mold. Blastocladiella emersonii. II. Influence of cellular and environmental variables on germination.


The sodium dependence of embryonic induction.


Ultrastructure and function in an insect heart.


Functional correlates of fine structure in the heart of achatinidae.


Structural and functional correlates of the myocardium.


This has been a good summer for ophthalmology.


Tympanic membrane VS "the drum".

Tympanic membrane VS "the drum".


Residency training and the community hospital.


Natural "contact lenses" in vertebrates.


Bilateral gunshot perforations with retention of useful vision: a case report.


Hemolytic glaucoma: a difficult clinical diagnosis.


Experiences with epidural endolymphatic shunt.


Use of helium in middle ear disease.

Use of helium in middle ear disease.


Followup services of a psychiatric population after audiometric screening: Results of pre-otologic clinic.


Some unsolved problems concerning infectious mononucleosis.


Hospital costs and controls in Canada and the United States.


An output approach to incentive reimbursement for hospitals.


Defining aggregations of the poor for community health center location.


A new proxy measure for health status.

A new proxy measure for health status.


A quantitative study of bone density in osteoporosis.


Cleidocranial dysostosis. A report of three cases.


The epidemiology of breast cancer: review and prospects.


Studies on cellular immunity and its serum mediated inhibition in Moloney-virus-induced mouse sarcomas.


Cellular immunity and its serum-mediated inhibition in Shope-virus-induced rabbit papillomas.


Ribonuclease-susceptible charged groups at the surface of Ehrlich ascites tumour cells.


Infectious but non-leukemogenic Friend leukemia virus obtained after prolonged cultivation in vitro.


Thoracic duct lymph cytology in Hodgkin's disease.


Smoking patterns in Africans and Indians of Natal.


A fee-per-patient-per-day basis for delivering pharmaceutical services to an institution.


Influence of neonatally administered hormones and early gonadectomy on rats' sexual behavior.


Active avoidance impairment following septal lesions in cats.


Intragastric reinforcement effect.

Intragastric reinforcement effect.


Thirst-hunger interaction. I. Effects of body-fluid restoration on food and water intake in water-deprived rats.


Validation of a corrected digital method of measuring changes in systolic blood pressure.


Electrical stimulation of the anterior cortex and skin-potential responses in the cat.


Role of association cortex in auditory-visual conditional learning in the cat.


Effect of amygdaloid lesions upon active avoidance acquisition and anticipatory responding in rats.


Effects of training procedures on transfer of observing and instrumental responses in discriminative reversals.


Conditioned motivational patterns in instrumental responding of rats.


Fear and punishment as determinants of passive-avoidance responding.


Influence of age on short-term retention of active-avoidance learning in rats.


Adaptation to curvature distortion.

Adaptation to curvature distortion.


Effects of vibrotactile adaptation on the perception of stimuli of varied intensity.


Effects of stimulus complexity, interstimulus interval, and masking task conditions in differential eyelid conditioning.


Respiratory and heart rate components of attention.


Comparison of short-term memory and visual sensory analysis as sources of information.


Synopsis of rape for the Florida examiner.


Examining the sexual assault victim.

Examining the sexual assault victim.


Newborn special care comes of age.

Newborn special care comes of age.


Small bowel atresia. Pathogenesis and treatment.


Testicular feminization. Report of three cases.


Evaluation of a new enzymatic paper-strip method for blood urea nitrogen estimation.


The community athletic medicine program.


Death--a concept to reconsider.

Death--a concept to reconsider.


From the files of the Committee for the Study of Maternal Mortality.


Subtotal gastrectomy versus vagotomy and antrectomy in the treatment of duodenal ulcer, a comparative study.


Estimated prevalence of chronic conditions in Kentucky.


Detection of asymptomatic urinary tract infection in girls.


The clinical associate: rationale for training a new health professional.


Studies on the nature and localization of acid phosphatase in normale and lens-regenerating urodele eyes. I. Histochemical localization.


Immunologic augmentations for learning and psychiatry.


Experimental effects of free serotonin on the brain and its relation to brain injury. 1. The neurological consequences of intracerebral serotonin injections. 2. Trauma-induced alterations in spinal fluid and brain. 3. Serotonin-induced cerebral edema.


Metallurgical principles in neurosurgery.


Experimental effects of free serotonin on the brain and its relation to brain injury. 2. Trauma-induced alterations in spinal fluid and brain.


Experimental effects of free serotonin on the brain and its relation to brain injury. 3. Serotonin-induced cerebral edema.


Reversibility of experimental cerebrovascular obstruction induced by complete ischemia.


Large abdominal cysts: a complication of peritoneal shunts. Report of three cases.


Trigeminal neuralgia, facial spasm, intermedius and glossopharyngeal neuralgia with persistent carotid basilar anastomosis.


Transthoracic removal of midline thoracic disc protrusions causing spinal cord compression.


Radiological demonstration of rupture of a carotid aneurysm during cerebral angiography. Case report.


Congenital venous malformation of the scalp associated with plexiform neurofibroma and cranial defect. Case report.


Benign osteoblastoma of the spine with multiple recurrences. Case report.


A case of oligodendroglioma studied with technetium-99m pertechnetate, the scintillation camera, and multiplane tomographic gamma-ray scanner. Technical note.


Effects of surround size and luminance on metacontrast.


Propagation velocity of lateral interaction in the human visual system.


Critical duration for the pupillary light reflex.


Reciprocity of the eye to 665-nm flashes.


Determination of the degree of crystallinity in solid-solid equilibria.


5(or 4)-[3,3-Bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide: a titrimetric determination of its v-triazolinium transformation product and studies of its stability.


Catalysis of streptovitacin A dehydration: kinetics and mechanisms.


Drug absorption. II. Effect of fasting on intestinal drug absorption.


Essential oil of Anemopsis californica. II. Minor constituents.


Dermatitic effect of nonionic surfactants. 3. Incorporation of 32P into phospholipids and acid soluble material of normal and surfactant-treated rabbit skin in vitro.


Biopharmaceutical studies of aminoethanesulfonylphenetidine I.


Behavior of erythrocytes in various solvent systems. V. Water-liquid amides.


Spectrophotometric analysis of glucose and mixtures of glucose, fructose, and sucrose.


Properties of monolayers of normal alkyl betaines at the air-water interface.


Hydrogenation of substituted isoquinolines over nickel catalyst. I. The effects of pressure and temperature on the hydrogenation of 5-nitro-2-alkylisoquinolinium salts.


Influence of ultraviolet irradiation on the surface activity of phenothiazine drugs.


Effect of colorants on the solubility of modified cellulose polymers.


Effect of polysorbate 80 on the solubility and in vivo availability of 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride (SK&F 33134-A).


Interpretation of percent dissolved-time plots derived from in vitro testing of conventional tablets and capsules.


Quantitative analysis of sodium sulfacetamide solutions in the presence of hydrolysis products, sulfanilamide and sodium acetate.


Inclusion compounds in pharmaceutical analysis. I. Determination of dienestrol in dienestrol cream.


Colorimetric determination of some sulfonamides with 9-chloroacridine.


In vitro assessment of dissolution kinetics: description and evaluation of a column-type method.


Identification of monomeric and polymeric 5,7,3'4'-tetrahydroxyflavan-3,4-diol from tannin extract of wild cherry bark USP, Prunus serotina Erhart, family Rosaceae.


On the additivity of molar attraction constants.


Preparation of some substituted imidazolidine-2,4-diones.


Effect of certain nonionic surfactants on the absorption of salicyclic acid from solutions by the frog, Rana pipiens.


Calculations of release rates from sustained-release dosage forms using the Wiley method.


Effects of 1,8-dihydroxyanthraquinone on different segments of rabbit gastrointestinal tract.


Reactivity of the hydroxyl groups in selected derivatives of lincomycin.


Some derivatives of 2-methyl-3-phenyl-3H-4-quinazolone.


Disproportionation of lidocaine sulfate dihydrate in certain organic solvents.


Further applications of the 4-(methylthio)-phenyl ester in peptide chemistry.


Surface structure, deep structure, and transformations: a model for syntactic development.


Influence of particle and cell concentration on phagocytosis of Cr2O3 by peritoneal macrophages.


Speech pathology and symptom therapy in the interdisciplinary treatment of psychogenic aphonia.


Uses of the Sheehan sentence completion test in speech therapy for stuttering.


A laryngectomee's viewpoint on the intelligibility of esophageal speech.


Validation of observer judgments in behavioral observation audiometry.


Carbohydrate metabolism in leukocytes. XII. Metabolism of the human lymphocyte.


Clinical impressions of portable masking unit effects in stuttering.


Positive-contrast peritoneography. Anatomy of the normal abdomen.


Human alpha-2 lipoprotein bands visualized by cellulose acetate electrophoresis.


Medical photomacrography.

Medical photomacrography.


Development of IgM memory in rats after antigenic stimulation of Peyer's patches.


Functional and cellular alterations produced by phytohemagglutinin. I. Depression of the phocytic activity and changes of liver cells.


Ethyl palmitate-induced splenic destruction.


Intrauterine transfusion. Radiologic procedure and observations.


Effect of passive antiserum on antigen phagocytosis and degadation by mouse peritoneal macrophages.


Carbohydte metabolism in leukocytes. XI. Stimulation of eosinophils and neutrophils.


This system plugs functional units into structural frame.


Out of money? now try using brains.

Out of money? now try using brains.


Effect of injected zymosan on inhalation of particulates.


Emergency care survey showsrange of facilities, staffing, treatment.


Radiolabeled latex particles ithe investigation of phagocytosis in vivo: clearance curves and histological observations.


The new trustee: out of the board room, into the action.


Operating room forum. Control nurse is needed to keep infection committee in action.


Continuing education may be required for pharmacist license.


Modern central service. These are steam sterilizing problems to guard against.


Versatile meat analogs will satisfy individual needs.


Shortages of other specialists may be hidden in nurse shortage.


Guns in the hands of hospital guards may do more harm than good.


To get public relations results, give P.R. a seat at the head table.


Limitation of staff membership must be supported by acceptable rationale.


Specific use must be studied in purchase of carpeting.


Some like it soon, some like it late; thrift-pension package suits them all.


Immutable law of public institutions: where money comes from, authority goes.


To meet coming union challenge: find out how workers feel--and why.


If you aren't listening to your employes, you may be asking for a union.


More raise for less money: the tax-sheltered annuity.


Batman joins the fight against frightening children in the x-ray suite.


Automation should not just fit old forms but aid new functions.


Setting the record straight.

Setting the record straight.


Action.

Action.


The needs of the dying.

The needs of the dying.


Occupational therapy and the nurse. 2.

Occupational therapy and the nurse. 2.


Congenital defects. 2.

Congenital defects. 2.


The first report of the Department of Health and Social Security.


A mobile clinic in an urban area.

A mobile clinic in an urban area.


Nanook of Eskimo Point.

Nanook of Eskimo Point.


Learning for living.

Learning for living.


The views of a health visitor on group practice attachment.


Restricted forms of muscular dystrophy: a study of 11 cases.


A correlative clinico-pathologic study of spinal cord injury.


The additional role of the scan in the diagnosis of cerebral tumours.