Dermatopathic lymphadenopathy a clinicopathologic  analysis of lymph node biopsy over a fifteen-year period. Forty cases of dermatopathic lymphadenopathy were found in a series of 906 consecutive lymph node biopsies (4.8 per cent). The histologic development and progression of the disease was correlated with the clinical state of the patient. In 35 of 40 cases the patients had active skin disease at the time of the biopsy; one of the remaining five patients had Hodgkin's disease, one had multiple myeloma and one had secondary syphilis. In the other two, no organic cause was found. In nine cases (22.5 per cent), the histological pattern typical of dermatopathic lymphadenopathy was associated with malignant lymphoma. Except for two biopsies, which showed coexisting malignant lymphoma and dermatopathic lymphadenopathy, no histologic features were found which distinguished patients with malignant lymphoma from the remainder. While the pathogenesis of the lymph node changes remains obscure, the histologic features suggest that it is at least in part an immune response, although the nature of the responsible antigen is unknown.


Dentist-physician relationship in extended care facilities.


The hypothalamic-pituitary-adrenocortical system. Clinical evaluation by  pharmacologic techniques. The hypothalamic-pituitary-adrenocortical system is a complex negative feed-back control mechanism. Under non-stress conditions it functions to maintain a circadian rhythm of adrenal steroid production which is secondary to a circadian fluctuation in the sensitivity to suppression of acth by hydrocortisone. Any stressful stimulus causes an augmentation of steroid production which is due in part to a decrease in sensitivity of acth to suppression. Aldosterone production is not primarily controlled by acth. The increased understanding of this system and of its pathologic alterations has led to the development of a number of pharmacologic techniques which have proved most valuable in evaluating its integrity. Hypothalamic-pituitary function can be assessed by the response to the administration of dexamethasone, methopyrapone, bacterial pyrogen and vasopressin. Adrenal cortical function can be assessed by the response to acth, dexamethasone and spironolactone.


Continuous culture of anaerobic rumen bacteria: modification and extension of the cyclone column culture system.


The deoxyribonuclease test as applied to certain gram-negative bacteria.


An experimental model of epithelialization of the anterior chamber.


The development of new vaccines. 3. Field studies.


Autonomy of parathyroid function in a patient with a renal homograft.


Some implications of psychotherapy research for therapeutic practice.


A look into the future of hospitals and their patients.


Theory of hypnosis since 1889.

Theory of hypnosis since 1889.


Dr. Montague gives personalized account of Albert Schweitzer.


J. Franklin Robinson, M.D., 1910-1966.

J. Franklin Robinson, M.D., 1910-1966.


References and resources useful in family life and sex education.


A pH 7 buffer devoid of nitrogen, sulfur, and phosphorus for use in bacteriological systems. Apparent pK values were determined for a series of commercially available carboxylic acids in a search for a buffer suitable for bacterial studies at pH 7 in media free from nitrogen, sulfur, and phosphorus. Of the compounds possessing pK' values near pH 7,3,6-endomethylene-1,2,3,6-tetrahydrophthalic acid (EMTA) was chosen as possessing suitable physical properties, cost, and purity for biological use. Aerobacter aerogenes and Escherichia coli grew normally in its presence but did not utilize it as a sole source and energy. Although good turbidimetric data could not be obtained, Pseudomonas aeruginosa responded in the same qualitative way. Therefore, EMTA promises to be useful in work on endogenous metabolism and in nutritional studies.


Inhibition of growth of Escherichia coli and of homoserine O-transsuccinylase  by alpha-methylmethionine. The methionine analogue, alpha-methylmethionine, inhibits bacterial growth, but its action is overcome by methionine, homocysteine, and cystathionine. The effect of the analogue on growth is attributed to its ability to mimic methionine as a feed-back inhibitor of the first enzyme specific to methionine biosynthesis. This conclusion is based on the findings that (i) alpha-methylmethionine inhibits excretion of O-succinylhomoserine, the product of the first enzyme, by a methionine auxotroph unable to convert succinylhomoserine to cystahionine, and that (ii) the enzyme homoserine O-transsuccinylase is inhibited by alpha-methylmethionine in extracts of Escherichia coli. alpha-Methylmethionine also inhibits methionyl-ribonucleic acid synthetase in extracts, but this inhibition probably does not affect growth.


A comparative study of two F-like colicin factors, ColV2 and ColV3, in Escherichia coli K-12. Of three colicin factors, each determining the synthesis of a colicin V in three wild-type Escherichia coli strains studied, two were shown to have sex-factor activities. In E. coli K-12, these activities resembled those of the F sex factor (including rapid and efficient self-transmission in exponentially growing cultures, adsorption of "male-specific" ribonucleic acid phage, production of "female phenocopies," elimination by acridine orange, and chromosomal transfer dependent upon recombination with host bacterium) and differed in this way from those of the colicin I sex factor (ColI). The two V factors, ColV2 and ColV3, differed in their efficiency of plating male-specific phage and in the pattern of transfer of chromosomal markers. Furthermore, although neither factor could stably coexist with F within the same cell, they showed markedly different exclusion effects. In general, ColV2 excluded F and ColV3 was excluded by F, irrespective of which sex factor was preestablished in the cell. An exception to this was the ability of ColV2 to stabilize in any one of a series of Hfr strains, giving rise to strains which in the majority of cases showed normal Hfr and colicinogenic properties.


Suppression of radiation sensitivity and capsular polysaccharide synthesis in Escherichia coli K-12 by ochre suppressors. A class of suppressors effective on nonsense polarity mutations suppresses several independent mutations in a gene (capR) that controls ultraviolet-radiation sensitivity and capsular polysaccharide synthesis. Since these ochre suppressors function at the level of translation of messenger ribonucleic acid into protein, the results provide evidence that the product of the capR gene is a protein.


Role for the female in bacterial conjugation in Escherichia coli. Hfr and F' Lac male strains of Escherichia coli were mated with purine-requiring females which had been starved for purine. These females formed mating pairs with the males. However, a mating in the absence of purine markedly reduced the yield of recombinants. Transfer of F' Lac or of lambda prophage also occurred infrequently. It was concluded that deoxyribonucleic acid transfer from male to female requires some, as yet unknown, function of the female.


Aldehydes and ketones produced during fermentation of glucose by Escherichia coli.


Deoxyribonucleic acid homologies among some bacteria.


Energy requirements for specific pair formation during conjugation in Escherichia coli K-12.


Catabolite repression is not due to end-product repression in the gal operon.


A walk through a ward of the Eighteenth Century.


Prepayment medical clinics of the Mesabi Iron Range: 1904-1964.


Samuel Johnson's tics and gesticulations.


Peripatetic pioneer: William Smith , M. D., D.O. (1862-1912).


Electrotherapy. A wood engraving by Daniel Urrabieta y Vierge (1851-1904). New Haven , Yale Medical Library, Clements C. Fry Collection.


Hypercalcemia and malignant disease.

Hypercalcemia and malignant disease.


Maxillary orthopedics and bone grafting in cleft palate.


An apparatus for delivering identical aliquots of uniform suspension of filamentous micro-organisms for use in growth studies.


A simple culture tube for anaerobic bacteria.


Public health in Canada, 1867 to 1967.

Public health in Canada, 1867 to 1967.


Annotated bibliography of Canadian military medical history. Preliminary checklist.


Treatment of cardiogenic shock.

Treatment of cardiogenic shock.


Clinical management of shock states.

Clinical management of shock states.


Medical treatment of arterial disorders of the extremities.


Treatment of septic shock.

Treatment of septic shock.


Medical therapy in arterial disorders of the extremities: Vasodilator drugs.


Surgical treatment of chronic aortoiliac and femoral arterial disorders.


Management of patients with lower extremity amputations.


Surgical treatment of arterial emergencies.


Theories of the psychological refractory period.


Wladimir von Dechterew is Wladimir von Bechterew: a typographical error.


Physiological psychology: or can a science over 95 afford to be "grubo"?


History of the practice of obstetrics in Utah.


Deadwood doctor.

Deadwood doctor.


The present status of ultrasonic diagnostic techniques in internal medicine.


Obstetric diagnosis with ultrasound.

Obstetric diagnosis with ultrasound.


Evolution of echo-encephalography in neurology--a review.


The management of leg ulcers in sickle cell anaemia.


Chemistry of nonenzymic browning. II.

Chemistry of nonenzymic browning. II.


Two surveys describe the effects of Medicare on Milwaukee area hospital utilization.


Techniques for sensory evaluation of food odors.


Device for counting plaques and bacterial colonies.


Unimolecular thermal transformations of organic compounds under food processing conditions.


Theory and practice of hard-surface cleaning.


Methods of meat texture measurement viewed from the background of factors affecting tenderness.


Ultrastructural study of leucocytes and urates in gouty arthritis.


A physician's viewpoint of Medicare.

A physician's viewpoint of Medicare.


Occurrence of antibody to salivary duct epithelium in Sjogren's disease, rheumatoid arthritis, and other arthritides. A clinical and laboratory study.


Endocardial cushion defects.

Endocardial cushion defects.


Some clinical and pathogenetic problems of porphyria.


Radiation and marrow infusion in leukaemia. Observations on a patient with chronic granulocytic leukaemia treated with whole-body radiation and infusion of isogenic marrow.


Funadmentals of functional neurochemistry.


Electric fire burn.

Electric fire burn.


Avicenna on the location of houses.

Avicenna on the location of houses.


Increased elastic tissue in the dermis: the dermal elastoses.


Purification and properties of fructose diphosphate aldolase from Fusarium oxysporum F. lycopersici.


Reversely directed branches arising from the left aortic arch. Report of a case.


Obituaries. Alexander Carr-Saunders.

Obituaries. Alexander Carr-Saunders.


The Amerindians of Guyana: a biological review.


The pathological anatomy of the islet apparatus in juvenile diabetes mellitus.


Utilization review in action.

Utilization review in action.


Legislation wrap-up. A report of: 1. Last health acts of the 89th Congress; 2. Medicare and extended care; 3. How Title XIX fares in 20 states; 4. Comments from state officials.


Clinical studies of methyldopa and its combination with chlorthalidone in hypertension.


Double-blind comparisons of topically applied steroids. A critical review of methods.


James Quinlan, formerly Surgeon-General to the Czar of Russia, 1826.


The detection of intracellular adenovirus type 12 antigens by indirect immunoferritin technique.


Size of figure drawings of depressed psychiatric patients.


Three principles for a psychoanalytic psychology.


Podiatry's role in the extended care facility.


Cutaneous hypersensitivity reactions to cellular isoantigens in rats. Rats have been shown to be capable of displaying the various kinds of delayed cutaneous hypersensitivity reactions attributable to transplantation immunity previously described in guinea pigs, hamsters, rabbits, dogs, and man. The rat is unlike most other species in that much larger numbers of lymphoid cells are needed to incite these cutaneous reactions. With direct, transfer, or normal lymphocyte transfer reactions, the cutaneous responses were greater when donor and recipient differed at the Ag-B histocompatibility locus than when donor and recipient shared the same Ag-B alleles. An experiment was performed in which adult rats of a genetically defined backcross population, resulting from matings between DA and (DA x Lewis) F(1) hybrid rats, were inoculated intradermally with lymph node cells from DA rats sensitized against tissues from Lewis-strain donors. Some of the R(2) animals gave a biphasic transfer reaction with peak reactivities occurring first at 48 hr and recurring at 96-120 hr, while the others lacked this second component. Hemagglutination tests revealed that the R(2) rats giving the biphasic response possessed the Ag-B,1 antigen, which is also present in Lewis rats, whereas rats which gave monophasic reactions were homozygous for the Ag-B,4 antigenic determinant which is present in the DA strain. This suggested that the recall flare at 96-120 hr reflects proliferative activity on the part of the inoculated cells confronted by the disparate Ag-B isoantigen in the host's dermis. Skin homografts from R(1) animals bearing the Ag-B,1 antigen were uniformly rejected by DA hosts in 11 days or less, while grafts from backcross animals homozygous for the Ag-B,4 antigen usually lived longer, being rejected in 9 to 27 days. Evidence is also presented which suggests that specific isoantibodies may act synergistically with immune lymphocytes to bring about cutaneous inflammatory reactions in the rat.


Effects of serotonin on the toxin of Clostridium botulinum.


Microradiographic and tetracycline uptake studies of bone grafts in dogs.


Filaroidiasis in the dog: a review.

Filaroidiasis in the dog: a review.


The effect of mesoridazine, a new thioridazine derivative, in alcoholics: a preliminary study.


Experiments with Thiersch's grafts in the operation for pterygium.


Precordial counting compared with arterial sampling for measuring the cardiac output in man.


Case report. Palatal gingival ridge.

Case report. Palatal gingival ridge.


Pigmentation of the oral tissues: a review of the literature.


A brief history of the State University of New York Upstate Medical Center.


An architect of medical education.

An architect of medical education.


The regulation of insulin secretion.

The regulation of insulin secretion.


Mediastinal emphysema complicating acute asthma. Report of two cases.


Miss Gertrude M. Gilman.

Miss Gertrude M. Gilman.


Organ grafting in man.

Organ grafting in man.


The location of genes controlling radiation sensitivity in Escherichia coli.


Review of headache. 3.

Review of headache. 3.


Life and times of Garcia da Orta (1500-1568).


Tetralysal.

Tetralysal.


Chemotherapy in the immunity deficiency syndrome.


Definitive syphilis serology.

Definitive syphilis serology.


Alteration of fd phage in tobacco leaves.


The isolation and quantitative assay of strains of tobacco mosaic virus on leaf disks.


Identification and localization of genetic material of African swine fever virus by autoradiography.


Genetic and developmental aspects of sleeptalking and teeth-grinding.


Review of consultation psychiatry and psychosomatic medicine. I. General principles.


Evaluation of Ronnel in schistosomiasis mansoni.


Purpuras in childhood.

Purpuras in childhood.


Anaerobic infections.

Anaerobic infections.


Dr. Friehs studies in United States.

Dr. Friehs studies in United States.


University of Adelaide Medical School founded in 1885.


A look at medicare.

A look at medicare.


Dr. Tridib Nath Banerjee.

Dr. Tridib Nath Banerjee.


Digestion and absorption in childhood.

Digestion and absorption in childhood.


A comparison of screening methods for the detection of significant bacteriuria.


Bacterial counts on urines--comparison of some methods.


State of Maine. Department of Health and Welfare. Maine's expanded Medical Care Program--Title XIX.


Dr. Sprague's role in the early history of MSP.


Clinical experience with the use of deprotenized calf bone in fifty four cases.


On the etiology and pathogenesis of hip dysplasia: a comparative review.


Some implications of organization theory for research on health services.


Research into the organization of medical practice.


The contribution of health services to the American economy.


Robert Alexander Ross.

Robert Alexander Ross.


The living past.

The living past.


Diabetes insipidus.

Diabetes insipidus.


Mariano Azuela, M.D. (1873-1952), physician and novelist of Mexican Revolution.


Homo erectus.

Homo erectus.


Proteolytic enzymes: fundamental concepts on their chemistry, uses and biological importance.


Clinical trial of a new bronchodilator formulation.


Clinical evaluation of clomocycline ('Megaclor') in general surgical practice.


Clinical evaluation of clomocycline ('Megaclor') in urological surgery.


Computer simulation of neurophysiological processes: implications for research in occupational therapy.


William Claire Menninger, M.D. October 15, 1899-September 6, 1966.


Kurt Lewin and field theory.

Kurt Lewin and field theory.


Review of--drug nomenclature publications.


Impact on pharmacy practice--recent federal legislation.


Home health services: challenge and opportunity.


Early fertility-management concepts in China.


The relative value studies: fixed conversion vs. customary fees.


Protection of lambs against tetanus.

Protection of lambs against tetanus.


Malignant diseases of the blood.

Malignant diseases of the blood.


Robley Dunglison, M.D., Thomas Jefferson's personal physician, and professor of the Institutes of Medicine and Medical Jurisprudence at Jefferson Medical College.


The problem of chronic pyelonephritis.

The problem of chronic pyelonephritis.


The management of tumours of the bladder.


Vesico-ureteric reflux.

Vesico-ureteric reflux.


The present status of renal transplantation.


Dialysis in the management of renal failure.


Tranquillization with a non-barbiturate hypnotic.


'The friend of the royal family'. Sir Henry Halford, G.C.H., M.D., F.R.S.


Neural mechanisms of sleep: changing view of reticular formation function.


Social reinforcement effects as a function of social reinforcement history.


Rapid eye movement sleep and cortical homeostasis.


In the service of sight: John Hughes Dunnington.


Deryl Hart, MD.

Deryl Hart, MD.


The air-route of spread of pathogenic bacteria in the operating room: control by bactericidal ultraviolet radiation.


Helminthiasis.

Helminthiasis.


Allometry and size in ontogeny and phylogeny.


William S. Halsted's New York period, 1874-1886.


Bacteriological monitoring of the hospital environment.


Thalamotomies and other stereotaxic surgery in childhood.


Ross Harrison's contributions to experimental embryology.


History of Section on Anesthesiology of the Connecticut State Medical Society.


The histochemical localization of enzymes in the human ovary.


Recent advances in ophthalmology.

Recent advances in ophthalmology.


The legal aspect of the doctrine of the seven uterine cells.


Transplantation behavior and cytogenetic characteristics of a spontaneous reticulum cell sarcoma in the golden hamster.


Albert Einstein. 2.

Albert Einstein. 2.


Ohio College celebrates 50th anniversary. The making of a dream.


The response to Liebig's vitalism.

The response to Liebig's vitalism.


Ludwig binswanger (1881-1966): a tribute.


The psychology of power.

The psychology of power.


Then and now. From auto-intoxication to auto-immunisation.


Bibliography of the history of medicine of the United States and Canada--1965.


Alfred Adler and Margaret Mead: a juxtaposition.


Note to a clergyman.

Note to a clergyman.


Adler and the Vienna College of Professors.


History of an anecdote used by Adler.

History of an anecdote used by Adler.


Observer bias in drug trial.

Observer bias in drug trial.


Blood levels of oxytetracycline on an 8 hourly oral regime.


Medicine in the United States: the road from yesterday to today.


William McFarland Boling--physician-teacher.


Brighter horizons for medical care.

Brighter horizons for medical care.


Minorities and Medicare.

Minorities and Medicare.


The first 60 days of Medicare.

The first 60 days of Medicare.


A new oral treatment of oriental schistosomiasis.


Historical clinical notes.

Historical clinical notes.


Dr. F. W. E. Burnham 1872-1957. A life of strange adventure.


Beta blocking agents for treatment of arrhythmias and angina.


The demography of mental illness in Maryland.


Skin replacement on the extremities.

Skin replacement on the extremities.


Quantitative urine cultures.

Quantitative urine cultures.


Foods and feeds as sources of carcinogenic factors.


Gastric function and structure in iron deficiency.


Gastric secretions before and after vagotomy.


Iron deficiency and growth.

Iron deficiency and growth.


Environmental temperature and choline requirement.


Experimental nutritional dystrophy and isozymes.


Triton and fat balance.

Triton and fat balance.


Renal control of acidosis.

Renal control of acidosis.


Study of isolated small intestinal cells.


Carbohydrate metabolism of rats consuming 450 p.p.m. fluoride.


Regulation of gluconeogenesis.

Regulation of gluconeogenesis.


Immunologic deficiency states. A review.


Hypersensitivity diseases of the lung. A review.


Osler on the teaching and study of medicine.


The human side of Osler.

The human side of Osler.


William Osler and medical journalism.

William Osler and medical journalism.


Osler in American medicine.

Osler in American medicine.


Pulmonary hypertension of cardiac and pulmonary origins. Pathologic aspects.


The anatomy of chronic cor pulmonale secondary to intrinsic lung disease.


Hemodynamics of cor pulmonale.

Hemodynamics of cor pulmonale.


Radiographic aspects of cor pulmonale.

Radiographic aspects of cor pulmonale.


Tampons in relief of symptomatic vaginitis.


Action spectra for photoreactivation of killing and mutation to prototrophy in U.V.-sensitive strains of Escherichia Coli possessing and lacking photoreactivating enzyme.


Contributions of twin research to psychology.


Solution of anagrams.

Solution of anagrams.


Research with the Wechsler Intelligence Scales for adults: 1960-1965.


On box score methodology as illustrated by three reviews of overtraining reversal effects.


The human body and bacteria. VII. Autosensitizatiion and allergy to bacterial products.


Muscular dystrophy. Man and Mouse. A review of current trends.


Deadwood doctor. V. Romance vs. lawsuits.


Usefulness of beta-galactosidase demonstration in diagnostic bacteriology.


C. H. Crownhart honored for 25 years sevice as secretary to the State Medical Society.


The physiology, psychology, and utilization of dreams.


Fluphenazine and amitriptyline in the anxious depressed patient.


A new technique for the isolation of cell nuclei using dimethyl sulfoxide.


Cytocidal effect of dimethyl sulfoxide on normal and leukemic lymphocytes.


The chemical and physical properties of DMSO.


The effect of DMSO on several enzyme systems.


The effect of DMSO on percutaneous penetration of hydrocortisone and testosterone in man.


Radioprotective and cryoprotective properties of dimethyl sulfoxide in cellular systems.


DMSO in stomatologic research.

DMSO in stomatologic research.


Clinical experience with DMSO in acute musculoskeletal conditions comparing a noncontrolled series with a controlled double blind study.


Local application of dimethyl sulfoxide and DMSO combined with triamcinolone acetonide in rheumatoid arthritis.


Clinical trials of dimethyl sulfoxide in rheumatoid arthritis patients in Japan.


The clinical use of dimethyl sulfoxide on various headaches, musculoskeletal, and other general medical disorders.


Dimethyl sulfoxide in the treatment of mental patients.


Strabismus.

Strabismus.


Syphilitic temporal arteritis.

Syphilitic temporal arteritis.


Aggregation properties of ribosomal protein from Escherichia coli.


The epidemiology of gout.

The epidemiology of gout.


The interpretation of proteinuria and the urinary sediment.


Pepsin as an esterase.

Pepsin as an esterase.


Methods of wound closure.

Methods of wound closure.


Dysphagia lusoria due to anomalous innominate artery.


Treatment of cholera.

Treatment of cholera.


Nobel prize winners in medicine.

Nobel prize winners in medicine.


Cornelius Ambrose Logan (1832-1899). A study of the Kansas physician, diplomat and writer.


Iproveratril--a new coronary dilator.

Iproveratril--a new coronary dilator.


1,2-benzothiazines. IV. The synthesis of 7,8-dihydropyridol[1,2-b][1,2-b]benzothiazine-10,11(9H, 10 aH)-dione 5, 5-dioxides as 1,2-benzothiazine analogs of partial tetracycline structures.


Effect of quinestrol on the coagulation mechanism.


Treatment of nausea and vomiting in children with diphenidol.


Effect of bacterial lipopolysaccharide on the content of serotonin and norepinephrine in rabbit brain.


Fractures and bone graft operations.

Fractures and bone graft operations.


Hemostasis.

Hemostasis.


Corneal transplants.

Corneal transplants.


A history of Presbyterian Hospital of Charlotte.


Neonatal sepsis.

Neonatal sepsis.


Etiology of gastrointestinal cancer in man.


Experimental alimentary tract cancer.

Experimental alimentary tract cancer.


Studies of the immunological aspects of salmonellosis of mice: active immunity.


Fluoride, bony structure, and aortic calcification.


Dietary carbohydrates and serum lipids of man.


Diets of the people on Tristan da Cunha.


Effects of malnutrition on smallpox and yellow fever vaccination.


Flushing in the carcinoid and dumping syndromes.


The energy of recovery from undernutrition.


Vitamin B6 status of cardiac patients.

Vitamin B6 status of cardiac patients.


Diet, glucose, insulin, and triglyceride responses.


Nutrients in wheat, flour, and bread.

Nutrients in wheat, flour, and bread.


Lysine-free diets and changes in exocrine pancreas cells in rats.


The influence of amino acid imbalance ON THE MECHANISM OF PROTEIN SYNTHESIS.


Wound healing in rabbits with a lysine deficiency.


Present knowledge of coenzyme Q.

Present knowledge of coenzyme Q.


Perception bibliography. XLI. Psychological abstracts, 1929, volume 3, second half.


Motor skills bibliography. LIX. Psychological index no. 2, 1895.


Motor skills bibliography. LX. Psychological index no. 3, 1896.


Motor skills bibliography. LXI. Psychological index no. 4, 1897.


Perception bibliography. XLII. Psychological abstracts, 1930, volume 4.


Motor skills bibliography. LXII. Psychological index no. 5, 1898.


Control of drawing style in the measurement of autokinesis.


Differences in Negro and white drawings: a cultural interpretation.


Social attitudes and their criterial referents: a structural theory.


A biological theory of reinforcement.

A biological theory of reinforcement.


Medicare and the nursing home's new image.


Microradiographic investigation of bone grafts in man.


Pattern copying and pattern walking performance of normal and educationally subnormal boys.


Holistic (Horney) psychoanalysis today.

Holistic (Horney) psychoanalysis today.


Sex-linked genes in man and Lyon hypothesis.


New developments in adrenergic blocking drugs.


The structure-activity relationships of beta adrenergic drugs and beta adrenergic blocking drugs.


Adenyl cyclase as an adrenergic receptor.


Adrenergic receptors in the myometrium.

Adrenergic receptors in the myometrium.


Central nervous system effects of beta adrenergic blocking drugs.


The biological effects of ozone on man and animals.


Clinical and hemodynamic appraisal of beta adrenergic blocking drugs.


Drug inhibition of catecholamine-induced metabolic effects in humans.


Surgical correction of coarctation of the aorta in the first year of life.


Evaluation of Sellers medium in identification of some gram-negative bacteria. The agar-slant medium of Sellers was evaluated as an identification aid in the differentiation between gram-negative bacilli of medical interest (Enterobacteriaceae excluded) and some of their saprophytic associates. With Sellers medium, a larger number of bacterial species and genera could be differentiated than with the oxidation-fermentation medium of Hugh and Leifson. Some species whose reclassification was recently suggested reacted on Sellers medium accordingly. Sellers medium (in a single tube) was found to be a distinct aid in the identification of a number of gram-negative bacteria which usually required several tests and an assortment of media.


Clostridium botulinum in marine sediments and in the oyster (Crassostrea virginica) from Mobile Bay.


Automatic control for evacuating anaerobic jars.


14-CO-2 trapping assembly for monitoring anaerobic microbial cultures.


Macrophage cytophilic antibodies and delayed hypersensitivity.


Delayed hypersensitivity and desensitization to chemical haptens: antigenic specificity of delayed hypersensitivity.


Identification of mannokinase in Escherichia coli.


Antigen-mediated depression of delayed hypersensitivity.


The role of antibody in delayed hypersensitivity.


Histology of allergic inflammation.

Histology of allergic inflammation.


Role of adjuvants in the production of delayed hypersensitivity.


Cytology of the induction of hypersensitivity.


Possible pharmacological mediators of delayed hypersensitivity.


The relationship of delayed hypersensitivity to acquired cellular resistance.


Cellular immunity and the homograft reaction.


Cell-mediated immune responses to virus infections and virus-induced tumours.


Delayed hypersensitivity in auto-immune disease.


Tuberculin reaction in tuberculosis.

Tuberculin reaction in tuberculosis.


Cellular resistance to tumours.

Cellular resistance to tumours.


Lepromin and Kveim antigen reactivity in man, and their relation to tuberculin reactivity.


Cell-mediated immunity--general perspectives.


The role of the macrophage in delayed hypersensitivity.


A critical review of endogenous psychotoxins as a cause of schizophrenia.


Imipramine in childhood nocturnal enuresis: relationship of time of administration to effect.


Differences in clinical effects of three phenothiazines in "acute" schizophrenia.


Mechanism of genetic recombination during bacterial conjugation of Escherichia coli K-12. I. Heterogeneity of the progeny of conjugated cells.


Mechanism of genetic recombination during bacterial conjugation of Escherichia coli K-12. II. Incorporation of the donor DNA fragment into the recombinant chromosome.


Genetic analysis of aromatic mutants of Salmonella typhimurium.


Auxiliary liver transplantation in dogs with arterialization of the portal vein. Preliminary communication.


Freud's view on pleasure and aggression.


Response of log-phase cells of Escherichia coli to medium limited in both sulfate and phosphate. In a study of the effects of a double nutritional deficiency, washed suspensions of log-phase cells of Escherichia coli increased in both turbidity and plate counts when incubated at 35 to 37 C in a medium deficient in sulfate and phosphate and buffered with tris(hydroxymethyl)aminomethane. The population approximately doubled within 6 to 9 hr, whereas the turbidity increased only 28 to 33% in the same period. Ribonucleic acid, deoxyribonucleic acid, and protein levels were followed, and changes were observed with time and deficiency state. Long-term experiments illustrated that a resulting population in a medium deficient in both sulfate and phosphate survived for 4 to 5 days, a longer period than that characteristic of the single deficiencies. Moreover, in media deficient in sulfate, E. coli possessed two completely distinct behavior patterns depending on the nature of the buffer used. In addition, a variation of one nutrient with a marked deficiency of the other suggested the existence of a controlling mechanism in E. coli which regulated the processes of cell division and survival, depending on the combination of conditions.


Epstein's pearls, Bohn's nodules and inclusion-cysts of the oral cavity.


Comparative studies with three antibiotics binding to deoxyribonucleic acid. The effects of the three antibiotics U-12,241, nogalamycin, and U-20,661 on (i) deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) synthesis in KB cell cultures and cell-free systems of bacterial and mammalian origin and on (ii) oxidative phosphorylation in rat liver mitochondria were compared. Nogalamycin and U-12,241 inhibited RNA synthesis more strongly than DNA synthesis in all test systems. Antibiotic U-20,661 inhibited DNA and RNA synthesis equally in whole mammalian cells and their corresponding cell-free systems. The RNA polymerase from Escherichia coli, however, was at least 100 times more sensitive to U-20,661 than was the DNA polymerase. U-12,241 caused significant uncoupling of oxidative phosphorylation in mitochondria.


Platyhelminthic parasites of invertebrates.


The Elmer Belt Library of Vinciana.

The Elmer Belt Library of Vinciana.


A man with a fine talent for idleness.

A man with a fine talent for idleness.


Guido Banti (1852-1925).

Guido Banti (1852-1925).


Radiation sensitivity in Escherichia coli: some properties of the radiation-sensitive Hfr K12 mutant, PAM 401.


Interaction of nitrogen mustard with polyribonucleotides, ribosomes, and enzymes involved in protein synthesis in a cell-free system.


Phagocytosis in mammalian hair.

Phagocytosis in mammalian hair.


Possible extracellular and intracellular bactericidal actions of mouse complement.


External chemical messengers. 3. Mind and body in schizophrenia.


Sunlight and frozen bacteria.

Sunlight and frozen bacteria.


Art in Medicine. Peripheral facial palsy throughout the ages.


Urinary diversion in congenital paraplegia.


Electromyography in spinal cord lesion with special reference to the sphincters.


The physiology and pathophysiology of constipation.


DNA-directed peptide synthesis. II. The synthesis of the alpha-fragment of the enzyme beta-galactosidase.


Megacolon and megarectum in older children and young adults. Classification and terminology.


Deficiency of 2-oxo-glutarate: glyoxylate carboligase activity in primary hyperoxaluria.


Experimental infections of calves with Trichostrongylus axei; the course and development of infection and lesions in low level infections.


Systemic Escherichia coli infection as a physiological stress in chickens.


The use of silver for intensifying sulfide deposits in the cholinesterase technique.


A multiple-compartment container for freeze drying, intermediate treatments, and paraffin infiltration of 32 specimens.


A vertical rotator for histological processing.


Methyl 2-cyanoacrylate monomer: a quick setting mounting medium.


The pharmaceutical exhibition at the Smithsonian.


Review and criticism of traditional drug distribution systems.


Brain and endocrine function.

Brain and endocrine function.


Recent developments in invertebrate endocrinology.


The neurosecretory neuron in neuroendocrine regulatory mechanisms.


American society of zoologists list of members.


Molecular variation and possible lines of evolution of peptide and protein hormones.


Techniques in gas chromatography. I. Choice of solid supports. A review.


Echo virus infection. A review.

Echo virus infection. A review.


Infectious porcine atrophic rhinitis: a review.


Non-atherosclerotic arterial lesions and their management. I. Trauma.


Non-atherosclerotic arterial lesions and their management. II. Inflammatory lesions of arteries.


Advances in virology--a review.

Advances in virology--a review.


In defense of settling plates.

In defense of settling plates.


Selection of patients and results of surgery for acquired valvular diseases.


An interview with Drs. Lee and Silver of HEW.


Management of respiration in tetanus.

Management of respiration in tetanus.


Impact of titles 18 and 19.

Impact of titles 18 and 19.


Fluid and electrolyte disturbances: a review.


New drugs in the management of acute leukemia, 1964-1966.


Recent advances in obstetrics and gynecology.


Pulmonary complications in surgical patients. A review.


Kinetics of permease catalyzed transport.


Studies on leptospiral colony formation in bottle culture: conditions favoring Leptospira icterohaemorrhagiae colony formation.


Annotated bibliography on protective services.


Radioactive phosphorus in the differential diagnosis of the malignant lymphoma and tuberculous lymphadenitis.


Present knowledge of vitamin E.

Present knowledge of vitamin E.


Linolenic acid and coronary heart disease.


Hunger during total starvation regimen.

Hunger during total starvation regimen.


Amino acid transport and insulin release.


Intestinal blind loops and folate metabolism.


Early latent diabetes mellitus.

Early latent diabetes mellitus.


Mineral oil in human tissues.

Mineral oil in human tissues.


Effect of nutrition and stress upon the metabolism of some barbiturate anesthetics.


Plasma amino acids in ruminants fed purified diets.


Starch digestion in ruminants.

Starch digestion in ruminants.


The size and frequency of rats' meals.

The size and frequency of rats' meals.


Metabolic effects of hypothalamic hyperphagia.


A review of autoimmunity in paediatrics: a clonal and selective approach to paediatric immunology. (II).


Doc. Dr Tadeusz Betkowski.

Doc. Dr Tadeusz Betkowski.


Correlations between dietary fatty acids and liver fatty acids in the rat.


Formation of an artificial vagina in a case of testicular feminization.


Metabolic myopathy.

Metabolic myopathy.


Edwin James 1797-1861: early Colorado physician, explorer and botanist.


"Miscellaneous" side effects during prolonged phenothiazine therapy.


Double-blind, controlled trial of oxazepam in the office practice of internal medicine.


Refractive keratoplasty--vergence calculations.


Some remaining problems of aldosteronism from personal case.


Roles of amino acid activating enzymes in cellular physiology.


Crystalline oxygenases of pseudomonads.

Crystalline oxygenases of pseudomonads.


Classification of Desulfovibrio species, the nonsporulating sulfate-reducing bacteria.


Pathogenesis of rashes in virus diseases.


Penicillinacylase.

Penicillinacylase.


Aflatoxin formation by Aspergillus flavus.


Inorganic polyphosphates in biology: structure, metabolism, and function.


Rapid laboratory diagnosis of diphtheria by fluorescent antibody technic. I.


Phenylketonuria.

Phenylketonuria.


Rapid laboratory diagnosis of diphtheria by fluorescent antibody technic. II.


Hemorrhagic transfusion reactions: a review.


"The vitreous face in cases of intracapsular operations--review".


Soft tissue operation for correction of neglected paralylic talipes calcaneus.


An account of the University of Kansas School of Medicine.


Cellular activity and cytokinetics in experimental skin grafts, studied with 3H-thymidine autoradiography.


Declaration of Helsinki. Recommendations guiding clinical research.


The Kansas Medical Society--1966-1967.

The Kansas Medical Society--1966-1967.


Medical emergencies. Introduction.

Medical emergencies. Introduction.


Emergency treatment of burns.

Emergency treatment of burns.


Medical emergencies arterial emboli.

Medical emergencies arterial emboli.


Maine's expanded medical care program--Title XIX.


Evidence supporting a praise decrement hypothesis in schizophrenia.


Effects of stereotaxic thalamotomy on intractable pain and numbness. Preliminary report.


Clinical studies on the action of ergocornine in women.


Indications for phenothiazines in general practice and clinical trial with thioridazine.


Cushing's syndrome: a historical review and etiological considerations.


The life and times of Galen.

The life and times of Galen.


Are hospitals ruining your children?

Are hospitals ruining your children?


The laboratory diagnosis of rubella infections.


An understanding of pain and its measurement.


Ethical and moral aspects of transplantation.


Renal effects of low molecular weight dextran.


The nutrition foundation's first twenty-five years: a quarter century of nutrition science progress.


Postpartum ovarian vein thrombophlebitis.


Localization of pepsin in the stomach, revealed by fluorescent antibody technique.


Extended care benefits after hospitalization under the Medicare program. Department of Health Education and Welfare sets forth explanation of benefits to be started January 1.


Deadwood doctor. VI. Some famous characters.


Planning new medical programs.

Planning new medical programs.


Coronary artery occlusion. A review of the surgical treatment and a study of myocardial peak lactic acid production at slow and fast heart rates.


Plasma renin concentration in human hypertension.


Air pollution.

Air pollution.


Pesticide residues.

Pesticide residues.


Pharmaceuticals and related drugs.

Pharmaceuticals and related drugs.


Clinical chemistry.

Clinical chemistry.


Tympanoplasty after radical mastoid operation.


Food.

Food.


Reconstruction of the pharynx using a penile skin graft.


Otitis media and complications.

Otitis media and complications.


Malaria among Puerto Rican veterans of the Viet Nam conflict.


The use of a rolled skin-fat flap in mammaplasty.


Authoritarianism, moral realism, and President Kennedy's death.


Indirect fluorescent antibody tests for parasitic diseases. 3. Conjugate-antigen relationships in the tests for trichinosis and schistosomiasis.


Interferons and other cell products influencing viral multiplication.


Chemotherapy of viral infections.

Chemotherapy of viral infections.


A handkerchief method for sampling the bacteriological nasal flora.


Smallpox and vaccinia.

Smallpox and vaccinia.


Common colds and related diseases.

Common colds and related diseases.


Morphological and antigenic sub-units of viruses.


Scrapie and its wider implications.

Scrapie and its wider implications.


Virulence in Newcastle disease virus. A preliminary study.


Recent advances in the study of viral oncogenesis.


Viral multiplication in vitro in relation to pathogenesis.


Reoviruses.

Reoviruses.


Rubella.

Rubella.


Replication of small RNA viruses.

Replication of small RNA viruses.


Six hundred years of medicine in Vienna. A history of the Vienna School of Medicine.


Citation and presentation of the academy plaque to Howard Reid Craig, M.D.


Citation and presentation of the academy medal to Donald D. Van Slyke.


The problems of the clinician in applied research.


Fruit aromas: a survey of components identified.


Ralph Moore Tovell, M. D., 1901-1967.

Ralph Moore Tovell, M. D., 1901-1967.


Robert Murdoch Miller, M.D., 1898-1966.

Robert Murdoch Miller, M.D., 1898-1966.


A review of olfaction.

A review of olfaction.


Paracusis Willisiana.

Paracusis Willisiana.


New problems beset area nursing homes.

New problems beset area nursing homes.


Raudixin in experimental and clinical hypertension.


Some explanations of the changing appearance of psychotic patients. Antecedents of the social breakdown syndrome concept.


Review and evaluation of current drug therapies in alcoholism.


Clinical pharmacology of imipramine and related antidepressant compounds.


Kidney transplantation.

Kidney transplantation.


Cyclosemigramicidin S.

Cyclosemigramicidin S.


Effects of partial and complete biliary tract obstruction.


Bacteriological and pathological aspects of diarrhoea in the dog.


A clinical approach to diarrhoea.

A clinical approach to diarrhoea.


Immunologic aspects of pulmonary emphysema.


Treatment of heart disease in the dog.

Treatment of heart disease in the dog.


Modification of the Astell roll tube apparatus for the enumeration and cultivation of anaerobic bacteria.


A seventeenth century microscope.

A seventeenth century microscope.


Progress in artificial voice aids.

Progress in artificial voice aids.


Hyperbaric oxygen therapy: its history and current scope.


Sex chromatin and chromosome analysis.

Sex chromatin and chromosome analysis.


The origin of legal medicine in France. Henri IV and Louis XIV.


Editorials: Lawrence Randall Boies, M.D.


Basic research contributions to otology.


Flaps and grafts in head and neck surgery.


Current trends in bronchial asthma. II.

Current trends in bronchial asthma. II.


The history of the Lehigh Valley Medical Association.


Medical history exhibit. William Penn Memorial Museum.


Medical secrecy.

Medical secrecy.


Blastoid transformation of rabbit and guinea pig peripheral lymphocytes by phytohemagglutinin.


In situ kidney pressure-flow-resistance relationship during endotoxin shock in dogs.


Response of the bear to endotoxin.

Response of the bear to endotoxin.


A possible explanation for decreased tryptophan pyrrolase activity in homogenates of liver from endotoxemic mice.


Mycoplasma granularum of swine origin as a tissue culture contaminant.


High voltage electron microscopy.

High voltage electron microscopy.


The human body and bacteria. IX. Steroids vs. immunization.


A historic review of nephroureterectomy.


Comparison of the fluorescent treponemal antibody absorption and Treponema pallidum immobilization tests on serums from 1182 diagnostic problem cases.


Fluorescent treponemal absorption and Treponema pallidum immobilization tests in syphilitic patients and biologic false-positive reactors.


A multiple inoculating device for bacteria.


Dr. John M. Sheldon.

Dr. John M. Sheldon.


The evolution of blood transfusion.

The evolution of blood transfusion.


Epidemiological aspects of respiratory mycotic infections.


Dr. Albert C. Furstenberg.

Dr. Albert C. Furstenberg.


Bacterial phosphatides and natural relationships.


Louis Napoleon and his doctors.

Louis Napoleon and his doctors.


Biodynamic effects of oligonucleotides.

Biodynamic effects of oligonucleotides.


Human papova (wart) virus.

Human papova (wart) virus.


Status of bacterial toxins and their nomenclature: need for discipline and clarity of expression.


Jenner.

Jenner.


Simplified differentiation from the Aerobacter and Paracolobactrum (Hafnia) groups.


Hyperglycemia. A risk factor in coronary heart disease.


Blocking procedure in histopathological technique.


Eli Ives of New Haven and Yale.

Eli Ives of New Haven and Yale.


Management of hypertension in pregnancy.


The use of bromelains in sinusitis: a double-blind clinical evaluation.


La Salpetriere: an early home for elderly psychiatric patients.


A report on three growth studies at the University of California.


Corrigan's Button.

Corrigan's Button.


Sociological aspects of learning and memory.


Strategy of outcome research in psychotherapy.


A look at HIBAC--the advisory council on Medicare.


Relationship of distortion to DAP diagnostic accuracy among psychologists at three levels of sophistication.


Cost calculations show where Medicare reimbursement formula fails.


Physicians and clergymen: barriers to interprofessional cooperation.


The man who taught deaf mutes to speak (Alexander Graham Bell).


One hundred years later.

One hundred years later.


Behavior therapy with children. A broad overview.


A. B. Baker, M.D.

A. B. Baker, M.D.


The penicillins.

The penicillins.


Heart-lung bypass. Perspective and present status.


Measurement of bacterial spheroplasts by the Timbrell double image micrometer and particle size analyser.


A rapid technique for the fixation and sampling of rat central nervous system for electron microscopy.


A histological tissue block-washer constructed from easily available components.


Isolation and identification of avian mycoplasma.


Time for statesmanship.

Time for statesmanship.


Role of the principal nursing home physician and upgrading of care.


Drug policy and regulations.

Drug policy and regulations.


Interplay of hospitals and extended care facilities.


Medicine's not so silent partner.

Medicine's not so silent partner.


Utilization review committees.

Utilization review committees.


The prevention and care of blindness and deafness in infants and children in England and Wales.


The basic principles of medicine in the primitive mind.


The evolution of the cottage hospital.

The evolution of the cottage hospital.


Samuel Johnson's alcohol problem.

Samuel Johnson's alcohol problem.


The origins of sympathectomy.

The origins of sympathectomy.


Sir Marc Armand Ruffer (1859-1917) pioneer of palaeopathology.


Swediaur: the vicious anti-Hunter rheumato-venereologist.


Dr. Hodgkin's relationship with his distinguished friend and patient, Sir Moses Montefiore, Bt., F.R.S.


Procreation, pregnancy, and parturition: extracts from a Middle English metrical encyclopedia.


Thomas Charles Hope (1766-1844).

Thomas Charles Hope (1766-1844).


Origin and meaning of the name 'carotis'.


Comparison of two federal programs: PL 89-749, Comprehensive Health Planning, PL 89-239, Heart, Cancer, Stroke.


Duodenal atresia and maternal hydramnios.


Missouri State Medical Association. Directory.


Acquired sideroblastic anemia. A review.


Anew interdisciplinary concept in teaching health services management.


Management of pancreatitis.

Management of pancreatitis.


Human renal homotransplantation.

Human renal homotransplantation.


Lyophilized bone in surgery of the external nasal pyramid and septum.


Human renal homotransplantation. II. Donor-recipient selection and histocompatibility testing.


Resuscitation of the moribund asthmatic.


Treatment of severe respiratory insufficiency in diffuse chronic lung disease by tracheostomy and intermittent positive pressure ventilation (IPPV).


A review of pilonidal sinus lesions and a method of treatment.


Treatment of respiratory failure following chest injuries.


What are perceptual reports about?

What are perceptual reports about?


Review of recent research on hypnotic learning.


The biographical information blank as a predictor of student achievement: a review.


Frontiers in heart surgery.

Frontiers in heart surgery.


Trends in medical education and care and the University of South Dakota School of Medicine.


Effect of aflatoxin B1 on the deoxyribonucleic acid polymerase of Escherichia coli.


Organelle pathology of the liver.

Organelle pathology of the liver.


Memoir of Charles C. Wolferth 1887-1965.


Memoir of George Morris Piersol 1880-1966.


Memoir of Adolph A. Walkling 1895-1966.

Memoir of Adolph A. Walkling 1895-1966.


Memoir of Max Bernard Lurie, 1893-1966.

Memoir of Max Bernard Lurie, 1893-1966.


Opsonic property of multiple myeloma serum.


Serum complement: changes after skin grafting in guinea pigs.


Memoir of Stephen Dana Weeder 1896-1966.


Memoir of Samuel Timothy Nicholson, 2d 1887-1966.


Memoir of William Oscar LaMotte, Sr. 1880-1966.


Everting end-to-end intestinal anastomosis in the dog.


The changing environment of medical practice. A brief presentation and panel discussion. 3.


Evaluation of a new trivalent bovine vibriosis bacterin using fluorescent antibody technic.


Vincent William Archer, M.D.

Vincent William Archer, M.D.


Intracervical injection of hyaluronidase. Effect on dilatation and length of labor.


Morphologic aspects of the placenta in gestational diabetes seen by phase-contrast microscopy. An anatomicoclinical correlation.


The syncytial knot: a sign of active syncytial proliferation.


Immunologic memory of the normal and the leukemic lymphocyte.


Controlled ventilation with intermittent positive-pressure breathing in the management of acute ventilatory failure associated with chronic obstructive pulmonary disease.


Skeletal muscle. Basic and clinical aspects and illustrative new diseases.


Viral arthritis.

Viral arthritis.


Amphiareion. A precursor of the Aesculapian temples of ancient Greece.


A history of alcohol problems in Kansas: 1854-1966.


Alcoholic women. Some considerations for further research.


Career scientists of the Health Research Council of the city of New York.


Fundamental principles in the correction of occlusal disharmony, natural and artificial.


In memoriam: Jane A. Russell.

In memoriam: Jane A. Russell.


Metabolism of progesterone in human proliferative endometrium.


Pacific Coast Society of Orthodontists membership roster.


Title XIX programs will soon surpass Medicare in size and in spending.


Effects of the neurohypophysial hormones on insulin secretion.


The sterility of multiple-dose vials in challenged.


The Board of Registry: Biological Photographic Association.


John A. Anderson, M. D.

John A. Anderson, M. D.


Rapid identification of coliform organisms from extra-intestinal infections.


An evaluation of Pagano-Levin medium in a quantitative study of Candida albicans: preliminary communication.


Modified technique of polyethylene glycol--wax embedding.


Distorting effects of histological processing: an historical review.


A physician on the glaciers. A note on the life of E. K. Kane, M.D.


Recent advances in psychiatry.

Recent advances in psychiatry.


Centennial neurology.

Centennial neurology.


Pathology 1966.

Pathology 1966.


Recent advances in anaesthesia in Manitoba.


1966 advances in clinical pathology.

1966 advances in clinical pathology.


The changing role of the pathology museum.


Drug addicts: are we creating them?

Drug addicts: are we creating them?


Moonshining--the real story.

Moonshining--the real story.


Dow V. Baxter (1898-1965).

Dow V. Baxter (1898-1965).


Mycoplasma pneumoniae infection in families.


Henry R. Carter--an overlooked skeptical epidemiologist.


Experimental aspects of hepatic regeneration.


Office dental care records.

Office dental care records.


The challenging era--are we too late?

The challenging era--are we too late?


Juvenile rheumatoid arthritis.

Juvenile rheumatoid arthritis.


Profile of Dr. Henry Marshall (1892-1960).


Nutrition reports.

Nutrition reports.


Vaginal cervicectomy.

Vaginal cervicectomy.


Comparison of hydroxyzine-meperidine and promethazine-meperidine for analgesia during labor.


A clinical concept of uterine blood flow during pregnancy.


Neurophysiology of the states of sleep.

Neurophysiology of the states of sleep.


Regulation of the circulation during exercise in man.


Role of the sympathetic nervous system in hemorrhage.


Cerebral and hormonal control of reflexive mechanisms involved in copulatory behavior.


Pharmacogenetics.

Pharmacogenetics.


Intrathecal and intraventricular kanamycin in the treatment of meningitis and ventriculitis in infants.


Topical kanamycin in dermatology.

Topical kanamycin in dermatology.


Solomon Weinstock and the miracle phenomenon.


Bibliography on attitudes toward hiring socially disadvantaged persons.


Two-process learning theory: Relationships between Pavlovian conditioning and instrumental learning.


Self-perception: An alternative interpretation of cognitive dissonance phenomena.


Control of memory by spreading cortical depression: A case for stimulus  control.


Retention of reinforcer magnitude.

Retention of reinforcer magnitude.


Penetrating the narrowing circle. A review of the literature concerning the vocational rehabilitation of homebound persons.


Comment on "apparent reversal (oscillation) of rotary motion in depth".


Masters in medicine...the Angell will case. Will broken on basis of psychiatric  testimony indicating insanity of testator.


New problems in public-private relationships.


Implications of the new social insurance mechanisms for other population groups.


Advances in the theory and practice of exchange transfusions. In the management and prevention of hemolytic disease of the newborn, exchange transfusions seem destined to remain the mainstay of therapy for some time to come. Our current knowledge of bilirubin metabolism has altered the indications for the procedure and introduced such useful new adjuncts to therapy as albumin infusions. The decision to do an exchange transfusion cannot be made by any one rule, but must be individualized for each patient and take into account all the factors known to influence the risks of bilirubin toxicity and the exchange procedure. A thorough evaluation of the infant's condition, particularly his cardiorespiratory and metabolic status (including blood pH, gas and albumin determinations), will provide valuable information as a guide to therapy. The limited capacity of some newborn infants to make adequate physiological adaptations to a variety of stresses imposed by the procedure influences the preparation of donor blood, the rate and volume of exchange and the time at which it should be done.A clear understanding of the mechanics of the exchange and the distribution of indirect bilirubin within the body will permit more accurate prediction of what can be accomplished in bilirubin removal and correction of hematocrit with exchanges of different volumes. When weighing the risk of kernicterus against that of exchange transfusion, the experience of the operator and the availability of suitable facilities cannot be ignored.


An integration of neurological factors in the spiral after-effect.


Preliminary clinical trial of Abbott antibiotic A-6413 (NSC-51954).


Dr. Arthur Williiam Hogg.

Dr. Arthur Williiam Hogg.


Drug dependence as a criterion for differentiation of psychotropic drugs.


Tribal surgery in East Africa during the XIXth century. 1. Ritual operations.


Malthus.

Malthus.


Protection against the toxicity of alkylating agents by thiols: the mechanism of protection and its relevance to cancer chemotherapy. A review.


The Veterans Administration longitudinal study of healthy aging.


Observations on halogens as bathing water disinfectants.


Pad culture studies on skin surfaces.

Pad culture studies on skin surfaces.


William Appleton Cuthbert 1912-1966.

William Appleton Cuthbert 1912-1966.


Isosorbide di-nitrate (Sorbitrate) in the treatment of angina pectoris.


Tolnaftate, its effectiveness in pedal mycosis. A preliminary report.


Comparison of two non-barbiturate hypnotics--methaqualone hydrochloride and meprobamate; a double-blind controlled clinical trial.


Reducing hospital infection.

Reducing hospital infection.


Voluntary health insurance for the disadvantaged.


Blue Cross-Blue Shield agreement in Alabama gives physicians louder voice in operations.


Medicine, stamps, and the history.

Medicine, stamps, and the history.


Quality control of tissue diagnosis.

Quality control of tissue diagnosis.


Megaloblastic anemia of pregnancy, report of three cases and literature review.


Some cation interrelationships.

Some cation interrelationships.


Psychiatry in the Philippines.

Psychiatry in the Philippines.


An early look (or review) of Medicare.

An early look (or review) of Medicare.


1966 members of Tennessee Medical Association.


A cinematographic study of the penetration of cultured cells by Toxoplasma gondii.


Exercise tests in heart disease.

Exercise tests in heart disease.


Board of Medical Examiners of Maryland.

Board of Medical Examiners of Maryland.


History of the Baltimore City Hospitals. 12. Some problems of the future.


The ampicillin resistance of Shigella sonnei: its epidemiological value.


Routine control of MacConkey agar and deoxycholate citrate agar: report of a working party of the Public Health Laboratory service.


External chemical messengers. I. Emission and reception in man.


Some thoughts on the clinical evaluation of drugs.


The effects of drugs on speech: a review.


Chlordiazepoxide hydrochloride in treatment of convulsive disorders. A three-year retrospective study.


Helminthiasis.

Helminthiasis.


Colonial morphology as a presumptive aid in identifying atypical and other mycobacteria: comparative study on three different types of culture media.


Application of the Mosaic Test upon Hindus and Muslims.


Alexander Forbes 1882-1965.

Alexander Forbes 1882-1965.


Regional lymph node blastic reaction evoked by first and consecutive skin grafts.


"Our greatest material heritage". The library 1946-1966.


The bulletin of the New York Academy of Medicine. 1847-1966.


Howard Reid Craig. An appreciation.

Howard Reid Craig. An appreciation.


The Committee on Medical Education. 1946-1966.


The Committee on Special Studies.

The Committee on Special Studies.


Howard Reid Craig.

Howard Reid Craig.


Use of arsenic in Trypanosomiasis. A historical footnote.


Dr. Walter Adams.

Dr. Walter Adams.


Virgines venenata.

Virgines venenata.


Gaylord W. Anderson, M.D.

Gaylord W. Anderson, M.D.


Amino-acids and peptides. VI. The synthesis, by twinning, of cyclodepsipeptides related to serratamolide.


Current concepts concerning the pathogenesis of the hyperthyroidism of Graves' disease.


The effect of procarbazine on leprosy.

The effect of procarbazine on leprosy.


Purse-stringing the bladder neck: an improved method of controlling post-operative haemorrhage.


John Roberton (1797-1876); obstetrician and social reformer.


Misericordia General Hospital: sixty-seven years of service.


100 years of dental progress in the nation's Capital.


Weaver, tailor or shoemaker? An osteological detective story.


Review of headache. I.

Review of headache. I.


Sir William Knighton, M.D. (1776-1836). Physician and Keeper of the Privy Purse.


Rehabilitation services for speech, hearing, and language disorders in an extended care facility.


The American Speech and Hearing Association presents the honors of the Association.


Post-surgical prosthesis. A case report.


The Institute of Medicine of Chicago: retrospective and introspective observations.


Liver fluke Fasciola hepatica in sheep and cattle in New Zealand and its control.


Cholera.

Cholera.


The development of current genetic concepts.


Human serum haptoglobins: a brief review.


Mechanisms by which some abnormal hemoglobins produce clinical manifestations.


Postvagotomy changes in the small intestine.


Regional absorption.

Regional absorption.


Orthopaedic care of children with myelomeningocele: a modern programme of rehabilitation.


Social and emotional adjustment of mildly retarded children and adolescents. Critical review.


Loci of actions of psychotropic drugs in the brain.


A history of Provident Hospital, Baltimore, Maryland.


The home health services for the aged population in Louisiana.


Psychologic characteristics of children with cystic fibrosis.


Erythropoiesis in protein starvation.

Erythropoiesis in protein starvation.


A simplified method of suturing the esophageal hiatus in the obese patient.


Patterns for the future.

Patterns for the future.


The mutual disposition of cholinoreceptors of locomotor muscles, and the changes in their disposition in the course of evolution.


The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation.


Deadwood doctor. 8. Horses and autos.

Deadwood doctor. 8. Horses and autos.


Dr. Henry Wirz and Andersonville Prison: a matter of justice.


Egon Freiherr von Eickstedt 1892-1965.

Egon Freiherr von Eickstedt 1892-1965.


Reflex regulation of ventricular work performance.


The House of Medicine.

The House of Medicine.


The psychotic son of Benjamin Rush.

The psychotic son of Benjamin Rush.


Homotransplantation of "live" hearts.

Homotransplantation of "live" hearts.


Background of the Litchfield County Medical Association of 1767.


The last illness of Sir Robert Walpole, First Earl of Orford.


A memorable centennial (Joseph Lister).

A memorable centennial (Joseph Lister).


Descriptions of psychiatric care in some hospitals during the first half of the 19th Century.


Out-patient cataract surgery.

Out-patient cataract surgery.


Medicare: an anniversary report.

Medicare: an anniversary report.


The pepsin-catalyzed hydrolysis of sulfite esters.


Therapeutic conflicts and the American medical profession in the 1860's.


The practice of medicine in New York a century ago.


Effects of training procedures on creativity test scores.


A Seventh-Century Chinese medical case history.


Climate and disease: the traveler describes America.


An account of the University of Kansas School of Medicine.


The early history of physical medicine and rehabilitation at the University of Minnesota.


Frank H. Krusen, M.D. Pathmarker in physical medicine and rehabilitation.


Dr. Ralph Moore Tovell.

Dr. Ralph Moore Tovell.


The doctors searcy--Reuben Searcy and his descendants.


Progress in renal transplantation --a review.


Medicare-Medicaid and the doctors of South Carolina.


Amyloidosis: review of cardiac and renal manifestations.


Medicare: way to make planning effective.


Utilization review: how to make it work.


Early medical practitioners in Gaston county.


Ileovesical fistula due to reticulum cell sarcoma.


Clinicopathologic Conference. Progressive dysphagia, cardiac arrhythmias, and congestive heart failure.


The changing face of nutritional thought--retrospect and prospect.


Diet and heart disease.

Diet and heart disease.


Cadmium and cardiovascular disease.

Cadmium and cardiovascular disease.


Survey diagnosis of skeletal fluorosis.

Survey diagnosis of skeletal fluorosis.


The genetics of alcoholism and color blindness.


Dietary solute load and the premature infant.


Magnesium deficiency AND CELL TRANSPLANT.


Thiamine intake and urinary excretion of thiamine metabolites by the rat.


Hepatic enzymes, species, and diet.

Hepatic enzymes, species, and diet.


Zinc deficiency and congenital malformations in the rat.


Letter from Australia.

Letter from Australia.


An address by Sir Hugh Linstead, Président d'Honneur de la Fédération Internationale Pharmaceutique. Some contributions by Dutch pharmacists to international pharmacy.


The historical development of ante-natal education and training.


Carbenoxolone in the treatment of duodenal ulcer.


Thalassaemia.

Thalassaemia.


Current views on haemostasis.

Current views on haemostasis.


A sedative-analgesic-antipyretic compound. A clinical trial in general practice.


Heart failure in myocardial infarction.

Heart failure in myocardial infarction.


The treatment of shock complicating acute myocardial infarction.


Pharmacological basis for the use of adrenergic  agonists and antagonists in cardiogenic shock and hypotension.


Acute cardiac tamponade. Pathologic physiology, diagnosis and management.


A consideration of the evolutionary and taxonomic significance of some biochemical, micromorphology, and physiological characters in the thallophytes.


History of a medical collection housed in the Denver public library 1893-1899.


Comparison of fluorescent and conventional darkfield methods for the detection of Treponema pallidum in syphilitic lesions.


A manual punch card system for recording, filing, and analyzing antibiotic sensitivity test results.


An apparatus for more objective evaluation of endpoints in latex agglutination tests.


Ophthalmology in Texas.

Ophthalmology in Texas.


Cystic fibrosis in adulthood.

Cystic fibrosis in adulthood.


The development of ophthalmology and otolaryngology in Virginia.


La Roque intra-abdominal approach for removal of hernia sac of inguinal and femoral hernia.


Some contributions of Anton T. Boisen (1876-1965) to understanding psychiatry and religion.


The origins of smallpox in Central Africa. I.


Bibliography on antibiotics and chemicals in plant pathology and physiology (1962-1966).


Antibiotics literature index. A select bibliography.


Postnatal development of the EEG in the dog. I. Introduction and EEG techniques.


Postnatal development of the EEG in the dog. II. Development of electrocortical activity.


Experimental split bladder preparation for study of individual kidney function.


Trypsin inhibitors of plant origin, their chemistry and potential role in animal nutrition.


Structure and function in the peripheral olfactory system.


Control of ciliary motion.

Control of ciliary motion.


Folic acid metabolism.

Folic acid metabolism.


Sound principles for prepaid medical care. Providing of quality medical care cannot be dissociated from fair and reasonable payments for service.


Psychotropic adjuvants in allergic disorders. Report of experiences with nortriptyline hydrochloride.


The serum flocculation test for the differential diagnosis of obstructive jaundice. Summing up of results and experience.


Possibilities of frenolon treatment in psychiatry.


A new antitussive (libexin) for geriatric use.


Antibiotics and the intestinal tract.

Antibiotics and the intestinal tract.


Medical practice calls for more antidepressant drug therapy. A study of 50 patients treated with pertofrane.


South African Orthopaedic Association. Twenty-fifth anniversary.


Pre-clinical testing of drug safety.

Pre-clinical testing of drug safety.


Circadian rhythms and shift workers.

Circadian rhythms and shift workers.


Problems in clinical trials.

Problems in clinical trials.


Historical aspects of the anatomy of the cardia with special reference to hiatus hernia.


Presentation of the fifth Ferdinand C. Valentine Medal and Award to Theodore M. Davis.


Ten years of the American Journal of Occupational Therapy: 1956-1965.


Memories of Anton Chekhov's family.

Memories of Anton Chekhov's family.


The psychiatric efforts of William Heberden, Jr.


The enumeration of bacteria in urinary tract infections.


The action of streptomycin on protein synthesis in vitro.


Opportunity in medical research in Africa. An historical approach.


Non-restraint and Robert Gardiner Hill.

Non-restraint and Robert Gardiner Hill.


The begetting of fools: an annotated translation of Paracelsus' "De Generatione Stultorum". 3. Discussion.


Some highlights in the history of amputation reflecting lessons in wound healing.


C. Mahlon Kline.

C. Mahlon Kline.


Interactions between alcohol and drugs.

Interactions between alcohol and drugs.


Immobilizing antibodies to Treponema Pallidum in the cerebrospinal fluid in syphilis.


Administrative implications of public law 89-97.


One can hear the one-hand clapping (Jean Piaget).


Systematic comparison or polemic? (Jean Piaget).


[Psychoanalysis and developmental psychology. Theory comparison revisited (Jean Piaget)].


Psychoanalysis and developmental psychology. Introduction (Jean Piaget).


History of development of the pill told by Mr. Hardt.


Psychoanalysis and the Geneva School of genetic psychology: parallels and counterparts (Jean Piaget).


Disinfectants in the dairy industry.

Disinfectants in the dairy industry.


Recent advances in automated lipid analysis.


Chlorine dioxide disinfection temperature effects.


The mode of action of antibacterial agents.


Factors affecting the recovery of gamma-irradiated Escherichia coli.


Preservation of Vibrio fetus by freeze drying.


Franz Hofmeister. The impact of his life and research on chemistry.


Treatment of arrhythmias due to digitalis.


Hospitals--Hill-Burton to Medicare.

Hospitals--Hill-Burton to Medicare.


A history and appraisal of intra-uterine contraception.


A simple liquid dispenser.

A simple liquid dispenser.


Trends in research in vascular disease.

Trends in research in vascular disease.


The Danish abortion laws.

The Danish abortion laws.


The historic promise of corrective therapy in American culture.


Chemotherapy in the treatment of advanced malignant disease.


The John Stewart Memorial Lecture. Intensive care--past, present and future (Joseph Lister).


Present knowledge of biotin.

Present knowledge of biotin.


Dietary intake and fat storage of pesticides.


Nutrition and metabolic bone disease in the elderly.


Fat and carbohydrate metabolism in patients with ischemic cardiovascular disease.


Pyridoxine dependency.

Pyridoxine dependency.


Intestinal absorption of chromium.

Intestinal absorption of chromium.


Effect of fructose and glycerol upon alimentary hyperglyceridemia.


Human serum cholesterol synthesis measured by deuterium labeling.


Salt in the infant's diet.

Salt in the infant's diet.


Alcohol and hepatic steatosis.

Alcohol and hepatic steatosis.


Symptoms of iron deficiency anemia.

Symptoms of iron deficiency anemia.


Methodological approaches to problems of transport of cholesterol and other lipids.


Metabolism of polyunsaturated fatty acids.


Regulation of salt intake in rats.

Regulation of salt intake in rats.


An improved screening procedure for blood phenylalanine.


Detoxifying crambe meal by ammoniation.

Detoxifying crambe meal by ammoniation.


Spontaneous arterial lesions in the antarctic seal.


Induced abortion and contraception: a consideration of ethical philosophy in obstetrics.


The occurrence of squamous epithelium in the endometrium.


Health officers of Cincinnati, Ohio and the problems of their day. 1900 to 1960. 8.


Suggestibility in the normal waking state.


Temporal factors in perception and short-term memory.


Small group ecology.

Small group ecology.


Ontogeny of volume regulations in embryonic extracellular fluids.


Steam radiography--a historical note.

Steam radiography--a historical note.


A current bibliography on allergy and applied immunology.


Presidential address.

Presidential address.


Drugs affecting human behavior: a challenge to every physician. Therapeutic revolution has not eliminated need for human relationship of doctor and patient.


Oxygen, an important pharmacologic agent.


Relationships between chemical structure and affinity for acetylcholine receptors. 1. Series of analogues of acetylcholine have been prepared in which the acetyl group was replaced by phenylacetyl, cyclohexylacetyl, diphenylacetyl, dicyclohexylacetyl, (+/-)-phenylcyclohexylacetyl, benziloyl and (+/-)-phenylcyclohexylhydroxyacetyl groups and the trimethylammonium group was replaced by Me(2)EtN(+), MeEt(2)N(+), Et(3)N(+), [Formula: see text] Further series were prepared in which the acetoxyethyl group was replaced by ethoxyethyl, phenylethoxyethyl, cyclohexylethoxyethyl, diphenylethoxyethyl, and dicyclohexylethoxyethyl groups, and by n-pentyl, 5-phenylpentyl, 5-cyclohexylpentyl and 5:5-diphenylpentyl groups.2. The ethoxyethyl and n-pentyl series contain some compounds which are agonists or partial agonists when tested on the isolated guinea-pig ileum, but all the other compounds are antagonists.3. The affinity of the compounds for the postganglionic ("muscarinesensitive") acetylcholine receptors has been measured in conditions in which the antagonists have been shown to be acting competitively. There were considerable differences between their affinities, the most active (log K, 9.8) having one million times the affinity of the least active (log K, 3.7).4. The changes in affinity as the onium group was modified were not entirely independent of changes in the rest of the molecule. Increasing the size of the onium group, as judged from conductivity measurements on simpler onium salts, increased affinity in the series containing one large group (phenyl or cyclohexyl) but, in the series with two large groups, affinity declined when the size was increased beyond -(+)NMeEt(2).5. In general, the effects of changes in the rest of the molecule on affinity were bigger than the effects of changes in the onium group and there were bigger interactions. Affinity was increased to a greater extent by introducing one phenyl and one cyclohexyl group together than by introducing either two phenyl or two cyclohexyl groups; the increment was greater than the separate contributions made by one phenyl and one cyclohexyl group.6. The factors which influence the binding of molecules to receptors are discussed. There is no evidence that the separation between the onium group and the group in the receptor with which it interacts is greater in compounds with high affinity nor is there any evidence, from the study of the series which contain agonists and partial agonists, that ability to activate receptors depends upon the onium group being able to come close to this charged group in the receptors.


Studies on the mode of action of hexobendine, a prospective anti-anginal drug. 1. In cats anaesthetized with pentobarbitone sodium, hexobendine (0.25 mg/kg) markedly increased myocardial blood flow (measured using a heat clearance technique) and usually decreased myocardial metabolic heat production, without influencing cardiac contractility or systemic arterial blood pressure. These effects lasted for about 45 min.2. Larger doses (0.5 and 1.0 mg/kg) decreased systemic arterial blood pressure and the rate of rise of the left ventricular pressure pulse (dp/dt), although left ventricular end-diastolic pressure was usually increased. This is indicative of a decrease in myocardial contractility.3. In a concentration of 5 x 10(-6) g/ml., hexobendine protected isolated rabbit atria against the decrease in contractility that follows the removal of oxygen.4. Hexobendine did not antagonize the systemic and myocardial effects of infusions of adrenaline and noradrenaline, nor (except in concentrations of 10(-5) g/ml.) the increase in contractility induced by these catecholamines on isolated rabbit atria.


The kinetics of elimination of salicylic acid and the formation of gentisic acid. 1. A method for the estimation of gentisic acid in urine has been devised which is based on thin-layer chromatography and fluorimetry.2. In man the urinary excretion of gentisic acid accounted for 0.6% of a 0.32 g dose of aspirin and 1.1% of a 1.28 g dose. The increase in the percentage of the dose excreted as gentisic acid provides further evidence that the elimination of salicylic acid cannot be entirely described by first order kinetics.3. Equations are presented which describe the amount of gentisic acid formed from various doses of salicylic acid in a model system, when elimination proceeds partly by simultaneous first order and zero order kinetics. The close agreement of the experimental and theoretical results indicates that the model provides an acceptable interpretation of salicylic acid elimination in man.


The effect of a large dose of atropine upon the performance of routine tasks. 1. A field trial was conducted in order to assess the effect upon tasks, including hard labour, skilled work, the use of instruments and tools and shooting, of giving 6 mg of atropine sulphate by injection to twenty-three adult male volunteers.2. Impairment of performance was seen in these tasks under the influence of the drug, but this was statistically significant only in some of them.3. Drowsiness occurred in twenty-one men and perceptual disorders were common, but two men were almost completely resistant to the effects of the drug.4. The implications of the therapeutic use of comparable doses of atropine are discussed.


Capacitance changes in frog skin caused by theophylline and antidiuretic hormone. 1. Impedance loci for frog skins have been calculated by computer analysis from voltage transients developed across the tissues.2. Attention has been paid to simultaneous changes in conductance and capacitance of skins treated either with antidiuretic hormone (ADH) or with theophylline. These drugs always caused an increase in conductance and usually the skin capacitance also increased. However, changes in conductance were not correlated with capacitance changes.3. Changes in capacitance caused by the drugs may represent pore formation in the barrier to water flow, since both drugs increase hydro-osmotic flow in epithelia. If this interpretation is correct, then 0.14% of the membrane area forms water-permeable pores in response to a maximal dose of ADH. This value is somewhat less than the value obtained previously (0.3%) by graphical analysis.4. A theoretical account is given of the relative accuracy of the computer method and the graphical method for voltage transient analysis.


Studies on the mode of action of vasopressin on the isolated proximal colon of the guinea-pig. 1. Contractions of guinea-pig isolated proximal colon produced by vasopressin are not affected by methyloxytocin (a compound that blocks pressor effects of vasopressin).2. Vasopressin contractions are inhibited by replacement of sodium with mannitol or sucrose, elevation of potassium or magnesium concentrations, the presence of the metabolic inhibitors sodium azide and triethyl tin or tetrodotoxin in the bathing fluid. Contractions produced by histamine or choline esters are comparatively insensitive to these procedures.3. Contractions of rat isolated uterus following vasopressin, oxytocin and methacholine are equally affected by replacement of sodium, increase of potassium or magnesium or addition of sodium azide.4. Neither vasopressin contractions nor contractions caused by transmural stimulation were consistently affected by morphine (10(-6) g/ml.) or hyoscine (10(-7) g/ml.) although both were reduced by anoxia or cooling the tissue. Morphine did not reduce the output of acetylcholine from stimulated colon.5. It is concluded that the action of vasopressin on proximal colon is unlike its action on other smooth muscle and is mediated by nervous tissue.


The pharmacological nature of the response of the reserinized guinea-pig vas deferens to postganglionic nerve stimulation. 1. Intracellular recordings from single smooth muscle cells of the guinea-pig vas deferens have been made after depletion of neuronal stores of noradrenaline by chronic reserpine treatment.2. Junctional responses to postganglionic hypogastric nerve stimulation were depressed, but large excitatory junction potentials (EJPs) and action potentials could still be evoked by stimulation at 1-2 c/s.3. These junctional responses were not reduced by the presence of hyoscine (5 x 10(-7) g/ml.), but were greatly depressed by the presence of bretylium (2 x 10(-6) g/ml.).4. Even in the presence of bretylium, junctional responses leading to action potentials could still be evoked by using high voltages of stimulation.5. It is concluded that when neuronal noradrenaline stores have been depleted by reserpine some noradrenaline is still available for release by nerve stimulation.6. It is further concluded that if the non-adrenergic component of the response of the guinea-pig vas deferens to nerve stimulation is cholinergic, this component is resistant to blockade by hyoscine.


The metabolism of orally administered L-Dopa in Parkinsonism. 1. Gas-liquid chromatographic methods were used to measure urinary acidic and alcoholic metabolites of L-DOPA, which had been administered in high oral dosage to patients with postencephalitic and idiopathic Parkinsonism.2. The output of these compounds was normal before treatment. During drug therapy, large quantities of the dopamine metabolites, homovanillic acid and dihydroxyphenylacetic acid, were excreted but traces only of 4-hydroxy-3-methoxyphenylethanol. Noradrenaline metabolites showed little change in output other than a small increase in 4-hydroxy-3-methoxymandelic acid.3. Information was obtained about a number of minor routes of degradation which might be implicated in the therapeutic action of L-DOPA. A raised output of m-hydroxyphenylacetic acid pointed to p-dehydroxylation of dihydroxyphenylacetic acid by gut flora. Evidence of transamination as a minor metabolic pathway was obtained by finding appreciable urinary levels of 4-hydroxy-3-methoxyphenyllactic acid. A keto-acid precursor of this compound may act as competitive inhibitor of an enzyme active in the normal degradation route of tyrosine, p-hydroxyphenylpyruvic acid oxidase, for increased amounts of p-hydroxyphenyllactic acid, the major metabolic derivative of p-hydroxyphenylpyruvic acid, accumulated in the urine during DOPA treatment.


Effects of chronic administration of (+)-amphetamine on maze performance of the rat. 1. The influence of (+)-amphetamine, given 1 min after each training session, on the performance of 124 rats in a Lashley III maze was measured every 48 hr.2. The first three injections of the drug significantly improved the learning ability of naive rats.3. With prolonged treatment, (+)-amphetamine strongly impaired the maze performance of these rats.4. The chronic administration of (+)-amphetamine to previously trained rats produced the same adverse effect.5. Amylobarbitone sodium given to previously trained rats 30 min before the training sessions completely blocked the adverse effect of (+)-amphetamine.6. (+)-Amphetamine did not produce impairment of performance when given chronically 30 min before training sessions, to previously trained rats.


Studies on the peripheral pharmacology of fenazoxine, a potential antidepressant drug. 1. The action of fenazoxine, a cyclized analogue of orphenadrine, has been studied on peripheral tissues innervated by adrenergic and cholinergic nerves. The hypothesis that cyclization of the alkyl amino chain of orphenadrine results in a molecule which retains the noradrenaline sensitizing action of orphenadrine but lacks the antimuscarinic activity has been investigated.2. The antimuscarinic activity of fenazoxine, on guinea pig ileum, was approximately 1/30 that of orphenadrine.3. Fenazoxine, desmethylimipramine and cocaine potentiated the response to noradrenaline and sympathetic nerve stimulation on the cat nictitating membrane, isolated rabbit ear artery and isolated driven atrial strip preparations.4. On the driven atrial strip preparation, fenazoxine at concentrations of 5 x 10(-7)M and 1 x 10(-6)M produced a small potentiation of the inotropic response to isoprenaline. At 5 x 10(-6)M and 5 x 10(-5)M fenazoxine antagonized the inotropic response to tyramine.5. Chronic denervation of the cat nictitating membrane abolished the potentiating action of fenazoxine.6. The results presented suggest that fenazoxine inhibits the uptake of catecholamines in a manner similar to that reported for desmethylimipramine and cocaine.7. Evidence is also presented which suggests that fenazoxine, like desmethylimipramine, possesses anti-noradrenaline activity at higher concentrations.


Blockade of biogenic amine synthesis: its effect on the responses to leptazol and dexamphetamine in rats. 1. The convulsive effects of leptazol in the rat are potentiated by prior treatment with dexamphetamine.2. An intact dopamine synthesis is necessary for the potentiation of the convulsive action of leptazol.3. An intact noradrenaline synthesis is not necessary for this action of amphetamine, as long as the dopamine synthesis is intact.4. An intact 5-hydroxytryptamine synthesis is not necessary for the potentiation to be shown.5. Blockade of either noradrenaline, dopamine or 5-hydroxytryptamine synthesis has no direct effect on leptazol convulsions.6. It is possible that it is an intact 3-4 dihydroxyphenylalanine (dopa) synthesis rather than an intact dopamine synthesis that is involved.


An electroencephalographic and psychiatric study of thirty-two insane murderers.


Homicide in Western Nigeria.

Homicide in Western Nigeria.


Remanded in hospital for psychiatric examination. Sec. 54, Mental Health (Scotland) Act, 1960--a review of 107 admissions.


Remanded in custody for psychiatric examination. A review of 83 cases, and a comparison with those remanded in hospital.


A short diagnostic self-rating scale in the pre-adult remand setting.


Psychiatric referral from a general practice.


Social class and mental illness in Dublin.


Chromosomes and mental changes in octogenarians. Preliminary findings.


Estimates of change in a depressive patient.


Marital patterns, hostility and personal illness.


The stability of scores on the Eysenck personality inventory in a university population.


Amphetamine taking among young offenders.


Attempts at chemotherapy of Echinococcus multilocularis infections in rodents.


Variations in the plasma proteins of Atlantic salmon (Salmo salar L.).


Some observations on the ultrastructure of the hummingbird pectoral muscles.


Effects of hypophysectomy on the testis and secondary sex characters of the adult guppy Poecilia reticulata Peters.


Effects of methyl testosterone on the testis and secondary sex characters of the hypophysectomized adult guppy Poecilia reticulata Peters.


Effect of prolactin on the density of mucous cells on the gill filaments of the marine form (trachurus) of the threespine stickleback, Gasterosteus aculeatus L.


Effect of prolactin on loss of solutes via the head region of the early-winter marine threespine stickleback (Gasterosteus aculeatus L., form trachurus) in fresh water.


Hormonal control of ovarian development and metamorphosis in Malacosoma pluviale.


The haematocrit centrifuge for the detection of trypanosomes in blood.


Ultrastructure of the eta cells in the pituitary gland of adult migratory sockeye salmon (Oncorhynchus nerka).


Prolactin and survival in deionized water of the marine form (trachurus) of the threespine stickleback, Gasterosteus aculeatus L.


The use of combination therapy in leukemia remission.


Clear cell carcinoma of the ovary.

Clear cell carcinoma of the ovary.


Studies on preoperative cancer chemotherapy. Methods of preoperative intra-arterial infusion by the use of methotrexate or vinblastine.


Basal cell carcinoma of the vulva.

Basal cell carcinoma of the vulva.


Cutaneous lymphoid hyperplasia.

Cutaneous lymphoid hyperplasia.


Malignant endovascular papillary angioendothelioma of the skin in childhood. Clinicopathologic study of 6 cases.


Transitional cell carcinoma of the prostate.


Malignant interstitial cell tumor of the testis.


Metastatic ganglioneuroblastoma. Ultrastructural, histochemical, and virological studies in a case.


Hepatic adenoma. Biochemical and electron microscopic study.


Unusual survival patterns of patients with metastatic melanoma.


Adenocarcinoma of bronchial epithelium arising in a retroperitoneal benign cystic teratoma.


Calcifying epithelial odontogenic tumor of Pindborg. An electron microscopic study.


Primary adenocarcinoma of the rectovaginal septum arising from endometriosis. Report of a case.


Primary adrenocortical carcinoma causing aldosteronism.


Hypercalcemia associated with estrogen administration in patients with breast carcinoma.


Chromosome and transplantation results of a human leukocyte cell line derived from a healthy individual.


Antibacterial effects of G 30'320 Geigy (B663) in lepromatous leprosy.


Measurement of scattered radiation to body areas during radiotherapy of basal-cell epitheliomas.


A peculiar, spotty pigmentation: report of five cases.


Mechanism of antifungal action of potassium iodide on sporotrichosis.


Reading difficulties in children.

Reading difficulties in children.


Drug dependence. I. Definitions, aetiology and prevalence.


Iodination of serum proteins in vivo: relationship to irradiation and hypertrophy of the thyroid.


"Hanseniasis," the new official name for leprosy in Sao Paulo, Brazil.


The influence of some progestogens on the mammary gland of the foetal mouse during the period of initial differentiation.


An outbreak of accidental vaccinia in a family.


Thyroglobulin biosynthesis in severely iodine-deficient rats.


The effect of copper and magnesium sulfate on inflammation.


The effect of exogenous gonadotrophins on the conceptus and corpus luteum in pregnant sheep.


Lobo's blastomycosis: new experiments on culture, immunology and inoculation.


The influence of the ovarian hormones on the actomyosin content and the development of tension in uterine muscle.


The design and precision of pigeon crop sac assays for prolactin.


Blood flow in the reproductive organs of the mouse after hypophysectomy, after gonadotrophin treatment, during the oestrous cycle and during early pregnancy.


Corticosteroid synthesis in vitro by adrenal tissue from newborn anencephalic infants.


Antibodies to a phyto-oestrogen: antigenicity of genistein coupled to a synthetic polypeptide.


Oestriol in amniotic fluid: a gas chromatographic method.


Induction and recall in contact sensivitity. Changes in skin and draining lymph nodes of intact and thymectomized mice. The cellular events in the ear skin and draining lymph node during the induction of contact sensitivity to 2-ethoxy methylene-5-oxazolone (oxazolone) have been studied in three strains of mice. The principal findings in the skin during the first 24 hr were invasion of polymorphs and destruction of pilosebaceous units, in both intact and thymectomized mice. Subsequently, the dermal cellular infiltrate increased and there was acanthosis of the epidermis. No lymphocytes were seen in the dermis or penetrating the epidermal basal cell layer in thymectomized mice. During the first 24 hr in the draining node, polymorphs and macrophages bearing a pigment with staining properties similar to melanin were seen in the marginal and medullary sinuses, in intact and thymectomized mice. Major differences, however, were revealed during 2-4 days when massive proliferation of large pyroninophilic blast cells occurred in the thymus-dependent area of the nodes from intact mice only. On testing, there was a prompt, measurable increase in ear thickness only in intact mice. This increase reached a peak at 24 hr - typical of a delayed type reaction. At testing, the ears from intact mice showed epidermal vesiculation and a considerable dermal cellular infiltrate with a substantial number of lymphocytes. This was in contrast with the completely quiescent appearance of the ear skin of thymectomized mice. Finally, we have discussed the use of the mouse as an experimental tool for studying contact sensitivity and have analyzed the role of the thymus-derived lymphocyte and the site where it becomes sensitized, in the light of current theory on the origin of cells and site where sensitization takes place in cell-mediated reactions.


Species specificity of leukocytic pyrogens. Polymorphonuclear neutrophilic leukocytes of the dog, cat, and goat release leukocytic pyrogen under the same conditions as the heterophile polymorphonuclear leukocytes of the rabbit. The characteristics of the febrile response to an intravenous injection of homologous leukocytic pyrogen in all four species are very similar: a brisk monophasic fever reaching a peak between 30 and 50 min with smooth defervescence to the baseline by 3 hr. Shivering, which is not obvious in the rabbit, is noted in the dog, cat, and goat during the first 30 min. Quantitative differences in response reveal the cat to be the most sensitive of of these species to homologous leukocytic pyrogen, followed by the rabbit, dog, and goat. The response to heterologous pyrogen is in most cases markedly diminished compared to that after equal doses of homologous protein, suggesting the operation of species specificity, although canine and feline pyrogen behaved very similarly in all tests. Species specificity of leukocytic pyrogen is probably related to amino acid substitutions in different species of a common mammalian protein effector molecule.


The requirement of serine esterase function in complement-dependent erythrophagocytosis. The p-nitrophenyl ethyl phosphonate esters have been shown to inhibit complement-dependent erythrophagocytosis when exposed to guinea pig polymorphonuclear leukocytes prior to the initiation of phagocytosis. Inhibition of phagocytosis occurred in a manner characteristic of the well-defined capacity of phosphonate esters to inactivate serine esterases: inhibition was irreversible, dependent upon the temperature of reaction and pH of the reaction medium, and proportional to the concentration of inhibitor used and the duration of exposure between leukocytes and inhibitor. Phosphonate inhibition was further shown to be independent of any general cell damaging effects of the compounds used. The phagocytic enzyme inhibited by phosphonate esters apparently exists in or on leukocytes in an already activated state prior to the initiation of the phagocytic process. The inhibitory profile of the activated phagocytic esterase was found to be essentially identical to the profile of inhibition previously obtained for the activated chemotactic esterase of rabbit polymorphonuclear leukocytes, suggesting that the same enzyme may function in both chemotaxis and phagocytosis. Various substrates including acetate esters reported to protect the activated chemotactic esterase from inhibition by phosphonate esters did not exhibit a clear protective effect in the phagocytic system and attempts to define the relationship between the two enzymes were unsuccessful. Suggestive evidence was also obtained for the requirement of the function of a second, activatable esterase in the phagocytic process.


Physical, chemical, and ultrastructural studies of water-soluble human amyloid fibrils. Comparative analyses of nine amyloid preparations. Amyloid fibrils were isolated from the tissues of nine patients with amyloidosis in a state of high purity by homogenization of the tissue followed by extraction with distilled water. Physical, chemical, and ultrastructural studies suggest that amyloid fibrils from different individuals resemble each other, but are not identical. In tissue sections as well as by negative staining of isolated fibrils, morphologic variations were observed. Among the isolated fibrils at least three types were noted. The majority resembled those described previously. However, one subject had two types of fibrils which differed in size and appearance. Most of the preparations sedimented as a single component with a sedimentation coefficient of 45-50S or as a larger polymer. However, two of the preparations had sedimentation coefficients of 8-9S, and a third one had a major 95S component and a minor 9S fraction. While the preparations of amyloid were not sufficiently pure for amino acid analyses, peptide maps demonstrated differences among amyloid preparations from different subjects. The amyloid fibrils in their native state proved to be remarkably resistant to digestion by a number of proteolytic enzymes. Several chemical methods were tried to produce smaller subunits. Of these, the most successful one was the use of 0.1 M NaOH which yielded a smaller, soluble fraction with sedimentation coefficients ranging from 1.1 to 2.8S. Accompanying this degradation, there was little loss of peptides or carbohydrates. Based on the results of the chemical analyses, it is estimated that the subunit produced by sodium hydroxide had a molecular weight of approximately 35,000-40,000.