Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 50-1969.


Apathy and Biafran aid.

Apathy and Biafran aid.


Hospital for Biafra.

Hospital for Biafra.


Coagulation and Shwartzman reaction.

Coagulation and Shwartzman reaction.


Acute lithium toxicity.

Acute lithium toxicity.


Alkaline phosphatase and hypernephroma.

Alkaline phosphatase and hypernephroma.


Assessment of salivary enzymes.

Assessment of salivary enzymes.


Wrinkles, smoking and osteoarthropathies.


Priority claims perilous.

Priority claims perilous.


Cardiovascular response to large doses of intravenous morphine in man.


Peripheral subresponsiveness to human growth hormone in the African pygmies.


Latent corynebacterium acnes infection of bone marrow.


Effects of early and vigorous exercise on recovery from infectious hepatitis.


Bacterial antigen in the kidney.

Bacterial antigen in the kidney.


Rest and exercise in hepatitis.

Rest and exercise in hepatitis.


Undue distinction of sex.

Undue distinction of sex.


Anticoagulant therapy in myocardial infarction.


The subclavian catheter.

The subclavian catheter.


Cord lesions after saddle emboli.

Cord lesions after saddle emboli.


Bronchospasm after reserpine.

Bronchospasm after reserpine.


Serum gastrin levels after total gastrectomy.


Ethanol gelation test.

Ethanol gelation test.


Anxiety precipitated by lactate.

Anxiety precipitated by lactate.


Metabolism of dopa in Parkinsonism.

Metabolism of dopa in Parkinsonism.


BCG vaccine (continued).

BCG vaccine (continued).


Perspective on priorities.

Perspective on priorities.


Quality of low-cost care.

Quality of low-cost care.


Criterion for incorporation.

Criterion for incorporation.


A note on the daily urinary excretion of estradiol-17-beta and estrone by the hen.


Mating behavior and fertility in the large white turkey.


Effect of wave length of light on growth and reproduction in Japanese quail (Coturnix coturnix japonica).


The effect of estradiol-17 beta-monopalmitate on yields and quality of chicken roasters.


Influence of oral administration of orally active estrogen and progestin on oviduct development of the immature pullet.


Protein and sulfur amino acid requirement of the laying hen as influenced by dietary formulation.


In vivo and in vitro incorporation of phosphorus-32 into deoxyribonucleic acid (DNA), spermatozoa and seminal plasma of the fowl.


Response to selection for bursa of fabricius weight at hatching in the domestic fowl.


The travel and residence of spermatozoa in the oviduct of the Gallus domesticus.


Influence of host genotype on mortality from lymphoid leukosis and Marek's disease after artificial and natural exposure.


Requirement of turkey poults for biotin and effect of deficiency of incidence of leg weakness in developing turkeys.


Further studies on the screening technique for determining salmonella-negative samples of pasteurized dried egg.


Liver, heart and adrenal weights of broilers reared under constant temperatures.


Oxidation of chicken tissue lipids as influenced by age and sex.


The influence of hen oviduct homogenates on the motility, oxygen uptake and fertilizing capacity of fowl spermatozoa.


Factors affecting the chick's requirement for phosphorus.


Broiler pigmentation potency of neoxanthin and violaxanthin relative to lutein.


Influence of dietary potassium on chick growth, food consumption and blood and tissue composition.


Time of emergence of turkey embryos.

Time of emergence of turkey embryos.


Effects of anesthesia on sensory evoked potentials in chicken brain.


A simple method of determining concentrations of ammonia in animal quarters.


Phosphocreatine. 2. Concerning the phosphocreatine in the egg.


The effect of egg albumen and of sperm immobilization on the rate of oxygen uptake by fowl spermatozoa.


The effect of diet and breed of chicken on the metabolic efficiency of nitrogen and energy utilization.


Growth characteristics of Pseudomonas fluorescens on conalbumin and lysozyme substrates.


Phosphorus in the nutrition of the adult hen. 2. The relative availability of phosphorus from several sources for caged layers.


Vitamin B12. The absorption of 57Co or 60Co-B12 by thlaying hen and mature rooster.


Effect of pinealectomy of coturnix quail reared under non-stimulatory photoperiods.


The metabolism of 36Cl-clopidol (3,5-dichloro-2,6-dimethyl-4-pyridonol) in chickens.


Effect of hypophysectomy on the radioactive phosphorus uptake of chick adrenals.


Availability of sodium in defluorinated rock phosphate.


Hemoglobin types in chick embryos with different adult hemoglobin genotypes.


Depletion and repletion of body xanthophylls' reserves as related to broiler pigmentation.


Formaldehyde levels on and in chicken eggs following preincubation fumigation.


Between family synchronization of hatching time in Bobwhite quail.


The effect of gold thioglucose on food consumption and reproduction of the Japanese quail (Coturnix coturnix japonica).


Nitrogenous metabolites in the plasma of chicks adapted to high protein diets.


Effect of iodinated casein and thiouracil on free amino acids in the blood plasma of chicks.


The effect of varying periods of water restriction tat different ages in broiler chickens.


Effect of gamma irradiated avian semen on reproductive performance.


Failure of dietary carbohydrates to influence tissue cholesterol in the adult male chicken.


Effect of dry heat on the internal quality of eggs.


Avian bioclimate chambers for research--with a note on panting thresholds in adult leghorn hens.


Number of salmonellae in commercially broken eggs before pasteurization.


In vitro calcium transport in laying fowl intestine: characterization of the system and medium composition.


Reproduction in white leghorn males fed various levels of dietary calcium.


Effect of physical and chemical treatment of grains on growth of and feed utilization by the chick. I. The effect of water and acid treatments of corn, wheat, barley and expanded or germinated grains on chick performance.


The effects of pre-cooling and warm packing on interior egg quality.


Sexual maturity and subsequent reproductive performance of white leghorn chickens subjected to different parts of the light spectrum.


Species and sex differences in the percentage of plasma trapped in packed cell volume determinations on avian blood.


Effects of six single species of coccidia on egg production and culling rate of susceptibel layers.


Whole body counter studies on the absorption of 60Co, 59Fe, 54Mn and 65Zn by chicks, as affected by their dietary levels and other supplemental divalent elements.


Salmonella infection of cracked eggs.

Salmonella infection of cracked eggs.


Perceptual independence: definitions, models, and experimental paradigms.


The development of cadmium-induced proteinuria, impaired renal function, and osteomalacia in alkaline battery workers.


Plasma insulin studies in two hundred patients with diabetes mellitus.


Studies with radioactive copper (64Cu and 67Cu): abdominal scintiscans in patients with Wilson's disease.


Tests of hypothalamic-pituitary-adrenal function in man.


Xanthinuria with myopathy (with some observations on the renal handling of oxypurines in the disease).


Pulmonary function studies.

Pulmonary function studies.


There is more to grass pollinosis than grass pollen and pollen counts. II.


Age determination of bovine foetuses.

Age determination of bovine foetuses.


Vasodilator action of parathyroid hormone used as bioassay.


The effect of inhalation of epinephrine aerosols in the dog.


The effect of furosemide on cerebrospinal fluid flow in rabbits.


Correlation between the antilipolytic and hypoglycemic actions of some salicylate structural congeners in normal and alloxan-diabetic rats.


Comparison of contracting agents on the isolated guinea pig aortic strip.


An electropharmacological comparison between quindine and dihydroquinidine on isolated rat atria.


Effects of chlorpromazine on two types of conditioned avoidance behavior.


A new anti-inflammatory agent 1-(4-chlorobenzoyl)-3-(5-tetrazolylmethyl) indole (BL-R743).


Salivary inhibition in mice and rabbits by a number of anticholinergics. A methodological investigation.


Fractionation and properties of rabbit transferrin.


Analgetic activity of alpha-1-(1-methyl-3-pyrrolidinyl)-1-phenylpropyl propionate fumarate (AHR-1767).


Equilibrium dialysis studies of transferrins.


A multidifferential amplifier.

A multidifferential amplifier.


Noradrenergic vascular responsiveness in hypertensive dogs.


Absence of a function for the crossed olivocochlear bundle under physiological conditions.


The effects of infused materials upon the regeneration of newt limbs. I. Blastemal extracts in denervated limb stumps.


Cell size, nucleic acids, and synthetic efficiency in the wild type and a growth mutant of the Multicellular alga Ulva mutabilis Foyn.


Sequential development of meristems in the embryo of Triticum durum. A DNA autoradiographic and cytophotometric analysis.


Toxicology and treatment of thallium poisoning by man.


Toxicological study of a fatal intoxication by man due to cannabis smoking.


On the radiological treatment of tumours of the lymphatic vessels.


Estimation of the genetic risk resulting from the treatment of women with 131-Iodine.


Behaviour and the possibility to quantitate behaviour. An account.


Clinico-laboratory and cytogenetic observations of persons subjected to professional irradiation with gamma-neutron sources.


Some introductory remarks on the concept of behaviour.


The possible utility of quantification of behaviour in psychiatry.


Interspecies radiotoxicological correlations and extrapolation of animal data to man.


Effect of irradiation on the erythropoiesis of rats after starvation and bleeding.


The living system: determination stratified.


Metropolis, macropolism megalopolis, ecumenopolis concrete jungle or flower checkerboard?


Microdissection study of the length of different tubular segments of rat superficial nephrons.


Fine structure of the intratesticular exretory pathway in the guinea pig.


Fine structure of the human foetal testis. I. The interstitial tissue.


Mitochondrial myelin-like figures: a non-specific reactive process of mitochondrial phospholipid membranes to several stimuli.


Ultrastructural observations on the biogenic amines in the carotid and aortic-abdominal bodies of the human fetus.


Some aspects of pediatric surgery on newborns transfused in utero for haemolitic disease.


The intensified drug inspection program: procedures and results.


Some aspects of the USP pyrogen test.

Some aspects of the USP pyrogen test.


Suicide prevention centers: comparisons of clients in several cities.


An evaluation of a program of continuing education in community mental health.


The role of personality variables in second language behavior.


Sleep disorder and symptomatology among medical and nursing students.


Psychiatric residents' appraisal of psychiatric teaching in medical schools.


Parenteral formulations. I. Comparison of accelerated stability data with shelf-life studies.


Prepsychotic adjustment and outcome in Italian schizophrenic patients.


Centrally mediated peripheral hypotensive effects of reserpine and hydralazine when perfused through the isolated in situ cat brain.


In vivo measurement of 5-hydroxytryptamine turnover rate in the rat brain from the conversion of C14-tryptophan to C14-5-hydroxytryptamine.


The mode of sodium dependency of the adrenergic neuron amide carrier. Evidence for a second, sodium-dependent, optically specific and reserpine-sensitive system.


Separation of the effects of alpha and beta adrenergic receptor stimulation on taenia coli.


Effect of propranolol of epinephrine-induced changes in cardiac rhythm and arterial potassium in dogs anesthetized with cyclopropane.


Some drug effects on calcium movements in aortic strips.


The effect of ouabain on calcium in subcellular fractions of cardiac muscle.


Factors that regulate ouabain-H3 accumulation by the isolated guinea-pig heart.


The metabolism of R(+)- and RS-pentobarbital.


Plants used against cancer. A survey.

Plants used against cancer. A survey.


Survey of Indian plants for saponins, alkaloids and flavonoids. I.


Plant admixtures to Ayahuasca, the South American hallucinogenic drink.


Enzymology of ergot alkaloid biosynthesis. IV. Additional studies on the oxidation of agroclavine by horseradish peroxidase.


Production of lysergic acid derivatives in submerged culture. V. Effect of surfactants on alkaloid accumulation.


The biosynthesis of mescaline in Lophophora williamsii.


Dioscorea tissue cultures. 3. Influence of various factors on diosgenin production by Dioscorea deltoidea callus and suspension cultures.


Thin-layer chromatography analysis of Mexican populations of Lophophora (Cactaceae).


The biosynthesis of visnagin from 2-14C-acetate by Ammi visnaga suspension cultures and the metabolism of 14C-visnagin and 14C-khellin by A. visnaga and A. majus.


Production of lysergic acid derivatives in submerged culture. VI. Alkaloid production after long-term storage under liquid nitrogen.


Povidone-dione (Betadine) for surgical antisepsis.


Methadone in the management of opiate addiction.


Principal findings based on thirty years' experience in endocrine psychiatry.


Failure of oxytocin and vasopressin to combine with an anti-insulin antibody.


Effects of the x-irradiation in vitro on the O2 uptake and on the utilization of glucose by the intestine.


Sialic acids. XI. On the thiobarbituric acid positive reaction in several materials from the vegetal kingdom.


Separation and properties of alpha and beta-galactosidase and other glycosidases from jack bean meal.


Iron transport capacity in the serum of fowl.


Modification of the phospholipids structure of platelets through the action of heparin.


Active immunization of mice with the avirulent Y strain of Trypanosoma cruzi against heterologous virulent strains of the the same parasite.


Steroid assays with radioactive isotopes, with special emphasis on the estimation of urinary aldosterone.


The enzymatic microestimation of urea.

The enzymatic microestimation of urea.


The handling and processing of data in a clinical chemical laboratory.


Sperm bundles and phylogenesis.

Sperm bundles and phylogenesis.


Some important problems of space physiology.


Relation of kind of background flying to tactical pilots' accident potential.


Psycho-physiological effects of flying on air hostesses.


Effect of flying on the menstrual function of air hostesses.


Psychotherapeutic treatment of depressions and neuroses in aviation medicine.


Physiological response to steady state hypoxia.


Cockpit noise intensity: fifteen single-engine light aircraft.


Flight research program. XIV. Landing performance in jet aircraft after the loss of binocular vision.


An attempt to produce acclimatization to hypoxia by intermittent altitude exposure with vigorous exercise.


Clinical significance of acquired complete right bundle branch block in 59 patients without overt cardiac disease.


Effects of various respiratory maneuvers on the physiological response to angular acceleration.


Impairment of mental performance at a simulated altitude of 8,000 feet.


Variations of spinal alignment in egress systems and their effect.


Cockpit noise environment of airline aircraft.


Gamma aminobutyric acid levels in brains of mice exposed to 20, 40, and 60 atmospheres He-O2 for 24 hours.


Physical fitness and tolerances to environmental extremes.


Sympathetic influences on the dark-discharge of the retina in the freely moving cat.


Changes in resting activity of retinal ganglion cells produced by electrical stimulation of the cervical sympathetic trunk.


Dissociation of electrocortical activity and somatic reflexes during rabbit hypnosis.


Cerebellar inhibitory control of the vestibular reflex pathways to primary afferents.


Phospholipid synthesis by foam cells in human.


Localization by autoradiography of phospholipid synthesis in rabbit atherosclerotic aorta.


Ultrastructural studies of renal peritubular amyloid experimentally induced in guinea pigs. 3. Blood and lymphatic capillaries.


The influence of the curved surface on the decrement lines for telecobalt-beams.


Ultrasonic investigation of the conformal changes of bovine serum albumin in aqueous solution.


The interaction of the ground and excited states of indole derivatives with electron scavengers.


On the determination of average pore size of membranes.


The problem of chronic bronchitis in general practice.


Treatment of pneumonia.

Treatment of pneumonia.


Pulmonary tuberculosis in the elderly.

Pulmonary tuberculosis in the elderly.


Spontaneous pneumothorax.

Spontaneous pneumothorax.


Byssinosis.

Byssinosis.


Multiphasic screening as part of family doctoring.


The natural history of idiopathic knock-knee in children.


Medical practice in Bhutan.

Medical practice in Bhutan.


A screening programme for the elderly in a general practice.


Obscure streptococcal syndromes.

Obscure streptococcal syndromes.


Hazards of general practice. A running commentary.


Synthesis of mono- and sesquiterpenoids. I. Racemic norcaran-2-one, trans-caran-2-one and trans-dihydrosesquicaran-2-one.


Observations in photosensitive children with and without epilepsy.


Inbreeding frequencies in the Balearic Islands (Spain).


Colitis cystica profunda.

Colitis cystica profunda.


Staphylococcal precipitins in normal and postinfectious human sera.


Two cases of IgG heavy-chain disease.

Two cases of IgG heavy-chain disease.


The XYY syndrome and aerospace operations.


Electroencephalographic and nerve-conduction studies in experimental vitamin B 6 deficiency in adults.


Vitamin distribution in red blood cells, plasma, and other body fluids.


Coronary heart disease in Hawaii: dietary intake, depot fat, "stress", smoking, and energy balance in Hawaiian and Japanese men.


Removal of exotic foreign objects from the abdominal orifices.


A practical method for decreasing the serum cholesterol level in man.


Adenocarcinoma of the rectal ampulla and rectosigmoid: comparison of the abdomino-perineal and anterior resections for cure.


The relationship between some proctological problems and rehabilitation medicine.


Familial polyposis.

Familial polyposis.


Clinical evaluation of a disposable microenema.


The levator ani spasm syndrome.

The levator ani spasm syndrome.


A thermo micro procedure for rapid extraction and direct application in thin-layer chromatography.


An automated solvent-extraction technique for radiochemical group separations: application to the analysis of glass fragments by thermal-neutron activation.


The determination of inorganic iodide in urine by neutron-activation analysis.


Determination of thallium in biological material by flame spectrophotometry and atomic absorption.


Rapid polarographic determination of chlorine, bromine and iodine in algae.


The determination of iron, manganese, zinc and copper in plant material by paper chromatography and reflectance densitometry.


Titrimetric determination of diuron in herbicide formulations.


Determination of manganese in blood and other tissues.


The dialysis of small volumes of fluid.

The dialysis of small volumes of fluid.


The size distribution of particles contaminating parenteral solutions.


Analysis of steroids. X. Determination of 21-amino corticosteroids.


Isolation of gastroferrin from human gastric juice.


The largest known monomeric globular proteins.


Some biological activities associated with the Fc' and pFc' subfragments of immunoglobin G.


Studies on the reduction of elastin. Biosynthesis and stability of the aldol condensation product of alpha-aminoadipic acid-delta-semialdehyde.


The displacement of membrane calcium by a local anesthetic (chlorpromazine).


The experience of time.

The experience of time.


Reiter's disease.

Reiter's disease.


Prophylaxis against infectious hepatitis.


Glue ear.

Glue ear.


Lymphovenous shunts in man.

Lymphovenous shunts in man. Lymphovenous shunts have been detected in patients by lymphography with Ultrafluid Lipiodol. No shunts were found in patients with normal lymphatic systems. They were found in patients with lymphoedema, with lymph nodes involved by malignant disease, and in patients who had had surgical interruption of lymphatic pathways, either vessels or nodes. The total incidence of lymphovenous shunts in 700 lymphographic studies was 2.3%. The incidence in the various pathological groups was highest in those with obvious lymph node involvement.In certain situations, particularly primary lymphoedema, the role of a lymphovenous shunt appears favourable to prognosis. In other situations a deleterious effect may be produced.


Kidney function after renal arterial embolism. Seven patients with atrial fibrillation had acute unilateral renal pain associated with suppression of function in the affected kidney. This was ascribed to renal embolism. Arteriography performed in four patients showed abnormalities in the renal arterial tree in three, though thrombus in a main artery was present in only one.Considerable function returned spontaneously to the affected kidney in six patients as judged by intravenous pyelography or renography. In two patients the sole functioning kidney was affected, leading to acute oliguric renal failure, but renal function recovered in each case. The routine use of anticoagulants in persistent atrial fibrillation is justified by such cases.


Serum growth hormone levels and size of pituitary tumour in untreated acromegaly. Serum levels of growth hormone were measured in 84 untreated acromegalic patients. The range of mean level during a glucose tolerance test was 8 to 1,860 ng./ml. and was lognormally distributed. Mean level was reproducible and correlated moderately well with maximum sellar area on lateral tomography. The hormone level was more responsive to oral glucose and insulin-induced hypoglycaemia in patients with smaller tumours. Attention is drawn to limitations of plain radiographs in assessing the size of a pituitary tumour. Suprasellar tumour extensions may be present in patients without visual field defects.


Abnormal haemoglobins in Zambia. A new haemoglobin Zambia alpha-60 (E9) lysine--asparagine. A survey for abnormal haemoglobins in Zambia has demonstrated Haemoglobin S-including 187 cases of sickle-cell anaemia, Haemoglobin J Oxford on one occasion, and a new Haemoglobin Zambia in four unrelated families. No evidence for beta-thalassaemia was found, but Haemoglobin H disease and other evidence for alpha-thalassaemia were found.


Proteins and insulin release: a dual role of amino-acids and intestinal hormones. In two subjects concurrent infusion of amino-acids and the hormones secretin and pancreozymin provoked much higher plasma insulin levels than did administration of amino-acids or hormones individually. It is suggested that this may be a physiological phenomenon, augmenting the release of insulin from the pancreas after a meal containing protein.


Sustained azathioprine-induced remission in Wegener's granulomatosis.


Effect of drugs on urate binding to plasma proteins. The effect of various drugs on urate binding to plasma proteins was investigated in normal subjects. Whereas allopurinol, aspirin, phenylbutazone, probenecid, and sulphinpyrazone all significantly reduced plasma urate concentrations, only aspirin, phenylbutazone, and probenecid significantly impaired urate binding. Colchicine and indomethacin in the doses administered had no significant effect on plasma urate concentrations or binding. In the case of aspirin, urate binding was reduced to 25% of normal, and this effect was quickly abolished after cessation of therapy. Phenylbutazone reduced urate binding to 56% and probenecid to 46% of normal; this impairment was still detected four days after cessation of therapy. Drugs may impair urate binding by competition for plasma protein binding sites, with displacement of bound urate. Impairment of urate binding in vivo by administration of certain drugs may be relevant to the precipitation of acute gouty arthritis, to the formation of gouty tophi, and to the augmentation of uricosuria. Furthermore, the role of drugs must be seriously considered during all studies on urate binding in patients with gout.


Accidental poisoning in children in Uganda.


Possible future trends of medical staffing in the hospitals of England and Wales.


Drugs for diarrhoea.

Drugs for diarrhoea.


Aids to surgery of common duct.

Aids to surgery of common duct.


Management of virus cental nervous system disease.


Anticoagulant therapy.

Anticoagulant therapy.


Meckel's diverticulum causing obstruction in a neonate.


Mite infestation.

Mite infestation.


Senile keratotic patches and topical vitamin A.


The density fractionation of hard tissues; the application of the "Coulter Counter" to the density-volume distribution of dried bone powders.


Intraspecies autosomal polymorphism and chromosome replication in Akodon molinae (Rodentia-Cricetidae).


Cytology and genetics of two abnormal ascus mutants of Neurospora.


The somatic karyotypes of American bison and domestic cattle.


The chromosome complement of rabbit blastocysts in relation to the time of mating and ovulation.


Chromosome number polymorphism in an Australian ponerine ant.


Aberrant segregation: a new case in Drosophila melanogaster.


Human chromosome morphology. I. Studies on normal chromosome characterization, classification and karyotyping.


Genetic homeostasis in Drosophila melanogaster.


An evolutionary dilemma: fitness of genotypes versus fitness of populations.


The spontaneous mutation rate revisited and the possible principle of polymorphism generating more polymorphism.


Laboratory administration.

Laboratory administration.


Genetic changes in the evolution of man.


Bilharziasis of the spinal cord.

Bilharziasis of the spinal cord.


A case of congenital erythroid hypoplasia in an African infant (Diamond-Blackfan syndrome).


Gambling aspects in medicine. 8. So, how good a punter are you?


Kaposi's sarcoma. Four cases to demonstrate differences in the manner of presentation.


Possible involvement of hydrogen ions in the chemical reactions of sulphur in flour.


Synovectomy of the proximal interphalangeal joint of the finger in rheumatoid arthritis.


Cushing's syndrome treated by intrasellar implants of radioactive yttrium. Report of five cases.


Clonidine in the management of milk hypertension in twenty-two patients.


Ceroid deposition in the muscularis of the small intestine, associated with regional enteritis. Report of a case.


Automated fluorometric method for the determination of serum calcium.


A method for measuring calcium crystalluria.


Photometric assay of differentiated oestrogens in urine following enzyme hydrolysis and gel filtration.


Micromethod for copper determination in serum and urine with 1,5-diphenylcarbohydrazide.


The serum cholinesterase variants. Differentiation by means of formaldehyde.


The occurrence of epsilon-N-methyllysine in human urine.


The coulometric determination of cholesterol in serum.


The assessment of phosphate reabsorption.


The determination of fructose in biological fluids using anthrone.


Wavelength dependency of the spectrophotometric determination of blood oxygen saturation.


An apparatus for vertical gel electrophoresis on microscope slides.


A multisample applicator for quantitative thin-layer chromatographic analysis.


Nalidixic acid and urinary steroids.

Nalidixic acid and urinary steroids.


Application of an enzymatic technique for measurement of ammonia in whole blood.


A rapid method for estimating transcortin on biogels.


Studies on the phenotyping of hyperlipoproteinemias. Evaluation of paper electrophoresis techniques.


Organ-identifying properties of alkaline phosphatases from canine tissues.


The effects of purification and serum proteins on the organ identifying properties of alkaline phosphatases from canine tissues.


Analysis of the distribution of lipoprotein patterns in healthy men and in patients with myocardial infarction.


A new procedure for the determination of hemoglobin.


A modified assay procedure for carboxylic ester hydrolases.


Quantitative investigation on the hippuric acid formation in healthy and diseased individuals.


Continous in vivo monitoring of human plasma cholesterol.


Quantitative measurement of C-reactive protein in serum.


The estimation of indoxyl sulphate in urine.


Lung scanning.

Lung scanning.


Microsomal epoxidation in Japanese quail: induction by dietary dieldrin.


The sterols of Trypanosoma cruzi and Crithidia fasciculata.


Precipitin test relationships among Argentinian species of the genus Ctenomys (Rodentia, Octodontidae).


Blood ion concentrations as a function of developmental stage in the gopher snake, Pituophis melanoleucus catenifer.


Nematode biochemistry. X. Excretion of glycerol by free-living nematodes.


Intrinsic cardiac rate regulation in the sea lamprey, Petromyzon marinus and rainbow trout, Salmo gairdneri.


The biosynthesis of phospholipids in the lobster, Homarus americanus.


Adrenergic and cholinergic vagal effects on the stomach of a teleost (Gadus morhua).


Ionic and osmotic regulation in three species of Cottus (Cottidae, Teleost).


Insect lipids: carbon number distribution of triglycerides in five species.


Amino acids in pupa of tsetse fly (Glossina palpalis).


Sterols produced by Synura petersenii (Chrysophyta).


Evaluation of support hose for women in treatment and prevention of edema.


Our voluntary agencies combat smoking.

Our voluntary agencies combat smoking.


Hemoglobin-Lepore-Baltimore, a third type of a delta, beta crossover (delta 50, beta 86).


On the interaction of nucleotides with basic polyamino acids. Cooperative binding behavior.


Incorporation in vivo of 14C-labelled amino acids into the proteins of mitochondrial ribosomes from Neurospora crassa sensitive to cycloheximide and insensitive to Chloramphenicol.


Mumps vaccine: rationale for its use.

Mumps vaccine: rationale for its use.


Reduction mammaplasty.

Reduction mammaplasty.


Infectious mononucleosis: recent developments.


Pills as radiologic artifacts.

Pills as radiologic artifacts.


Diagnosis and treatment of congenital rubella.


Malignant sympathetic tumors in children.


Management of urinary tract infection.

Management of urinary tract infection.


Arthrography of the shoulder.

Arthrography of the shoulder.


Papillary muscle dysfunction.

Papillary muscle dysfunction.


Studies on the biosynthesis of ovarian steroids.


Carcinoma of the thyroid.

Carcinoma of the thyroid.


Radiation-induced thyroid disease.

Radiation-induced thyroid disease.


Addison's disease at Guy's Hospital: a pathological study.


Endocrine abnormalities in chronic liver disease.


Who uses job evaluation programs.

Who uses job evaluation programs.


Preliminary observation on dermatoglyphics in genodermatosis.


A case of Kaposi's sarcoma.

A case of Kaposi's sarcoma.


Eczema and neurological disorders in association with malabsorption syndrome.


Tuberculin and lepromin tests in patients with tuberculosis.


The skin as a mirror reflecting internal malignancy.


Dimethicone 20 B.P.C. (SILOCERM)--a new multipurpose skin protective barrier ointment as prophylaxis in skin diseases, a preliminary report.


Aetiology, natural course, pitfalls in diagnosis and prevention of skin carcinoma.


Squamous cell carcinoma.

Squamous cell carcinoma.


Benign tumours of the skin.

Benign tumours of the skin.


Lymphoma.

Lymphoma.


Adnexal carcinomas.

Adnexal carcinomas.


Kerato-acanthoma.

Kerato-acanthoma.


The place of surgery in the treatment of skin cancer.


Precancerous dermatoses and intraepidermal carcinomas.


Cytotoxic agents in skin malignancy.

Cytotoxic agents in skin malignancy.


Preliminary phytochemical and pharmacological studies on Ficus racemosa (Gular).


World drug programs.

World drug programs.


Profession of pharmacy in modern Greece.


The cannabis problem in the United Kingdom.


A research-based pharmaceutical company.


Marijuana in Vietnam.

Marijuana in Vietnam.


Biblical drugs.

Biblical drugs.


Reproductive performance of western and Dorset X Western ewes under a fall-lambing program.


Some postpartum reproductive phenomena in the domestic rabbit.


Efficiency of utilization for fattening of the metabolizable energy of molasses-based diets.


Quantitative variation in ovarian and follicular development in four genetic groups of pigs at different ages.


Poloxalene for bloat prevention in lambs.


Protein effect on growth and carcass composition of swine selected for high and low fatness.


Nicotinic acid--tryptophan relationship in the nutrition of the weanling pig.


Comparative study of the digestibility of forage cellulose and hemicellulose in ruminants and nonruminants.


Comparison of opaque-2 corn, milo and wheat in diets for finishing swine.


Uterine capacity at two stages of gestation in gilts following embryo superinduction.


Induction of heat, ovulation and fertility in gilts with delayed puberty.


Testicular growth and related sperm output in dairy bulls.


Local effect of the early sheep embryo upon uterine motility.


Urea utilization in wethers receiving the urease inhibitor, acetohydroxamic acid.


Influence of creep feeding and post-weaning diethylstilbestrol implantation on post-weaning weight gain and carcass composition of beef bulls.


Haemoglobin norms for healthy South Indian adults.


A clinico-pathological study of renal amyloidosis in northern India.


Percutaneous cardiac biopsy.

Percutaneous cardiac biopsy.


Primary pulmonary hypertension (clinical, haemodynamic and pathological study).


Clinical study of pyelonephritis.

Clinical study of pyelonephritis.


Hepatic amoebiasis and its treatment with metronidazole.


Endemic typhoid fever in the railway population of Ajmer (a study of over 300 patients).


Case of malignant lymphoma presenting as Mikulicz syndrome.


Student experiments on the gel filtration of proteins.


Remission of intractable asthma in a child during psychotherapy of the mother.


A model antigen-antibody system for classroom use.


Biosynthesis of an antibiotic. A 14C tracer experiment.


Bile acids. 28. Gas chromatography of new bile acids and their derivatives.


Separation of permitted and non-permitted solvents for use in foodstuffs by gas chromatography and the use of a solid sampler for the estimation of residual solvents in oils and oleoresins.


The determination of chlorinated hydrocarbons using the negative alkali flame detector response.


Gel filtration in lipophilic solvents using hydroxyalkoxypropyl derivatives of Sephadex.


Quantitative gas chromatographic determination of 5,5-dimethyl-2,4-oxazolidinedione.


Polytetrafluoroethylene layers for thin-layer chromatography.


Fractionation of oligonucleotide isopliths by electrophoresis on polyacrylamide gels.


A new mold inhibitor for amino acid analyzer buffers.


Gas-liquid chromatographic separation of heptono-1,4-lactones as trimethylsilyl derivatives.


A quick separation of the epsilon-N-methyl-lysines using the amino acid analyzer.


A new accelerated fully automated system for amino acid analysis by ion-exchange chromatography.


Chromatography of fish pituitary extracts on Sephadex G-100.


Polyamide layer chromatography. XXII. Separation of quinones.


The detection of steroids by silicotungstic acid on Gelman sheets.


Separation of the herbicide C-6989 and some related compounds by thin-layer chromatography.


Improvement of the chromatographic properties of Sephadex G-15.


A simplified method for the preparation of immunoglobulin G by gel filtration-centrifugation.


Polyamide-silica gel thin-layer chromatography of water-soluble vitamins.


Determination of several ammonia or amino acid samples on one chromatogram with an amino acid analyzer.


Determination of hydantoins in pharmaceutical preparations by gas chromatography.


Gas-liquid chromatography of protein amino acid trimethylsilyl derivatives.


An improved method for the gas chromatographic identification of digitalis cardenolides.


Attribute preference and discrimination shifts in young children.


Age and sex differences in responses to Embedded Figures and Reversible Figures.


The child's concept of proportionality: a re-examination.


Two attempts to condition eyelid responses in human infants.


The infant's free entry into a new environment.


The magnitude of the orienting response in children as a function of changes in color and contour.


An experimental analysis of the criteria used by children to judge quantities.


Facilitation of transposition and reversal learning in children by prior perceptual training.


Some effects of novelty and overtraining on the reversal learning of retardates.


Young children's initial and changed names for form-color stimuli.


The effect of perfusion rate on in vitro percutaneous penetration.


The 1970 session of the General Assembly of Iowa will consider several important pieces of health legislation.


Inorganic phosphate therapy of hypercalcemia.


Clinicopathologic conference. Recurrent pneumonia with sinusitis and angiitis.


Personnel policies for the medical office.


Prosthetic replacement of the aortic valve. A current assessment of operative results.


Digitalis: continuing problems related to its use.


Expanding home-health services.

Expanding home-health services.


Botulism--a case report.

Botulism--a case report.


Structure of plasma sphingadienine.

Structure of plasma sphingadienine. The dienic long-chain base (sphingadienine) of human plasma sphingomyelins has been identified as d-erythro-1,3-dihydroxy-2-amino-4-trans-14-cis-octadecadiene. A similar sphingosine was also detected in plasma sphingomyelins of rat, rabbit, and cat. The key reaction in the structural studies was partial reduction of sphingadienine with hydrazine to cis-14-sphingenine and 4-sphingenine.


Physiological effect of cardiovascular surgery.


Inhibition of lymphatic absorption of cholesterol by cholestane-3 beta, 5 alpha, 6 beta-triol. The effect of cholestane-3,5alpha,6-triol (CT) on the intestinal absorption of cholesterol and oleic acid, as well as the absorption of labeled CT, was studied in lymph ductcannulated rats. Intragastric administration of 50 mg of CT in an emulsion with cholesterol-7alpha-(3)H and oleic acid-1-(14)C resulted in 50% inhibition of sterol transfer into lymph but only 8% depression of fatty acid absorption over an 8 hr period. The absorption of labeled CT into lymph was only 2-3% compared with 50% absorption of cholesterol when each was fed alone. 10% of the fed CT was recovered in the intestinal mucosa, and of this, one-half was associated with the brush border fraction. In rats fed CT 6 days prior to cholesterol and fatty acid administration, there was no effect on fatty acid absorption, while cholesterol absorption was reduced by almost 30%. When the intestinal mucosa from these animals were investigated by electron microscopy, it appeared that CT feeding resulted in numerous enlarged mitochondria and a marked increase in length of the microvilli. If animals were allowed to recover for 6 days from the CT prefeeding regime, the intestinal mucosa appeared normal, and the absorption of cholesterol approached that in controls. A possible mechanism for CT inhibition of cholesterol absorption was shown to be competition for the enzyme cholesterol esterase which esterifies cholesterol prior to entrance into the lymphatic system. CT itself is poorly esterified and poorly absorbed, but it is effective in inhibiting esterification of cholesterol in vitro.


Treatment of shock following myocardial infarction.


Medical aspects of community fallout shelter confinement.


Thrombophlebitis and underlying cancer.

Thrombophlebitis and underlying cancer.


The infant with cyanotic congenital heart disease.


Status of emergency room practice.

Status of emergency room practice.


Pilot application of a teaching technique in social medicine.


A survey of some attitudes and practices in surgical education.


A longitudinal study of potential change agents in medicine--a preliminary report.


Graduate medical education in basic sciences.


Medical students' attitudes toward the mental health field: a longitudinal study.


Synthesis of multiple criteria of physician performance.


The crisis in american medical education: the student viewpoint.


Attitudes toward grading systems used in medical education.


OEO-AAMC grant.

OEO-AAMC grant.


An accrediting of externships: one approach.


Multidiscipline teaching laboratories at Hershey.


One faculty's sources of information regarding change in medical education.


Datagrams: first-year enrollment 1969-70.


A comparative study of the ring glands from wild type and 1(2)gl mutant Drosophila melanogaster.


Distichiasis and epicanthus: a study of one family.


Thyroid function tests.

Thyroid function tests.


The citizen doctor.

The citizen doctor.


Transthoracic needle biopsy of the lung: and its complications.


Reye's syndrome: clinical and pathological features.


Temporal lobe seizures with psychomotor status.


An ultrastructural study of experimental demyelination and remyelination. 3. Chronic experimental allergic encephalomyelitis in the central nervous system.


The surface structure of some renal cell membranes.


A stereologic study of the effects of metopiron on the rat adrenal.


Studies of the phylogeny and ontogeny of the specialized lymphatic tissue venules.


Histochemical changes in galactosidase and glucuronidase in the reticuloendothelial system of the neonatal rat.


The in vitro effect of hydrocortisone on cultures of peritoneal monocytes.


Induction of large thrombi in hyperlipemic rats by epinephrine and endotoxin.


Distribution of cholesterol-1,2-H3 during maturation of mouse peripheral nerve.


1. The electrocardiogram in clinical alterations of potassium homeostasis.


Electrodes for cardiac monitoring in the coronary care unit: description of the disposable daisy electrode.


Clinical uses of central venous pressure.


Sickle cell disease in pregnancy. A report on exchange transfusions.


Phlebography in leg complaints.

Phlebography in leg complaints.


Diagnostic treatment trends.

Diagnostic treatment trends.


Guidelines for admission of slcohol-dependent patients to general hospitals.


The nutritional status of C/Y center children.


A new haemostatic-vasoconstrictor agent for the control of bleeding.


The profession and the community.

The profession and the community.


The World Health Organization's medical research activities.


Hospital costs and payment: suggestions for stabilizing the uneasy balance.


Depression as a side effect of oral contraceptives.


The care of chronic illness: the "responsor" role.


A publicly funded pharmacy program under Medicaid in New York City.


The geographical distribution of malignant melanoma in Queensland.


Operative aseptic precautions in large bowel surgery.


The annual fiasco (American style).

The annual fiasco (American style).


On a rule for group decision-making.

On a rule for group decision-making.


Rupture of the jejunum as an isolated injury in closed abdominal trauma.


A fatal case of phaeochromocytoma.

A fatal case of phaeochromocytoma.


The relative effectiveness of different approaches to the surveillance of infections among hospitalized patients.


Psychiatric disorders in the general practices of an island.


Problems of experimental research in the urban ghetto.


Ohio Congressman introduces bill for separate U.S. Health Dept.


Complications of chronic mastoiditis.

Complications of chronic mastoiditis.


Neonatal mortality in a private hospital. A four year study with some suggestions for prevention.


Rubella: a preventable cause of congenital deafness.


Maternal deaths from hemorrhage due to ruptured uterus and associated afibrinogenemia, with statistical analysis of 75 cases.


Acardiac monsters and conjoined twins.

Acardiac monsters and conjoined twins.


In Ohio's Mental Hygiene Program, Mental Retardation Division is created.


Annual roundup on federal, state, and local taxes for physicians.


OSMA Economic Research Program takes shape--director named.


Investment prognosis...

Investment prognosis...


Site of origin of periodic complexes. (An EEG study with use of intracarotid sodium amytal).


Epispadias and exstrophy.

Epispadias and exstrophy.


Paralytic ectropion and reconstruction of the outer canthus.


An eye surgeon's thoughts about eyelid reconstruction.


Malignant melanoma: the problem of lymph-node metastases.


Language disorder.

Language disorder.


Recurrent meningitis.

Recurrent meningitis.


Oesophageal atresia in a cretin.

Oesophageal atresia in a cretin.


Exchange transfusion in a 7-year-old girl with sickle cell anaemia as preparation for adenoidectomy.


Coeliac dwarfism with good response to late treatment.


Severe acidosis during a painful sickle cell crisis.


Amine  metabolism in brain.

Amine  metabolism in brain.


Amines and abnormal mood.

Amines and abnormal mood.


Renal salt and water excretion in different states of an intrarenal control system.


Cardiovascular reflexes and the intrarenal regulation of sodium excretion.


Catabolism of iodine-labelled fibrinogen.


An assessment of Anderson-Hynes pyeloplasty by radioisotope renography.


Radioactive fibrinogen as an index of thrombosis.


Measurement during fibrinolytic therapy.


The meaning of physical fitness. Introduction.


International relations in medicine.

International relations in medicine.


Some physiological aspects of fitness for sport and work.


The champion athlete--limiting factors in record-breaking.


The attitude of the club athlete.

The attitude of the club athlete.


The effect of heat on acclimatized and unacclimatized groups of very fit men.


Physical activity and coronary heart disease.


The effect of mental and physical strain on the cardiovascular system.


An actuarial view of coronary disease.

An actuarial view of coronary disease.


A heterogeneity of the HD-receptor, demonstrable by HD-cold antibodies: HD1-HD2-immunochemical aspects.


Mechanical refuse disposal.

Mechanical refuse disposal.


Genetics and preventive medicine.

Genetics and preventive medicine.


Plastics in refuse.

Plastics in refuse.


Nutrition of the elderly. Present and future research.


The noise nuisance.

The noise nuisance.


Steroid 3-oxetanones. II. The dipole moments of some cholestane ring b oxetanones and oxetanols.


22-trans-cholesta-5,22,24-trien-3-beta-OL -- an intermediate in the conversion of stigmasterol to cholesterol in the tobacco hornworm, Manduca sexta (Johannson).


The measurement, excretion, and source of urinary 6-hydroxycortisol in humans.


Testosterone metabolism in target tissues. Hypothalamic and pituitary tissues of the adult rat and human fetus, and the immature rat epiphysis.


Determination of urinary cholesterol by gas-liquid chromatography.


The measurement of low levels of estrone & estradiol-17-beta in urine, employing ion-exchange, thin-layer, and gas-liquid chromatography.


Identification of some urinary conjugated metabolites of 17-beta-estradiol-6, 7-3H-17-glucosiduronate in the human female.


The electron capture response following gas liquid chromatography of various halogenated derivatives of 17-beta-oestradiol and oestrone.


Maternal and umbilical cord plasma concentrations of steroids of the pregn-4-ene C-21-yl sulfate series at term.


Steroid conjugates. V. The synthesis of a sulfoglucuronide derivative of estriol.


A dynamic aortic patch as a permanent mechanical auxiliary ventricle: experimental studies.


Oxygen-18 exchange reactions in steroidal ketones. Determination of relative rates of incorporation by gas chromatography-mass spectrometry.


The scrotal dimple in testicular torsion.


An ultrastructural evaluation of the closure of the ductus arteriosus in rats.


Duplication of the anus and genitourinary tract.


Structure of torilin.

Structure of torilin.


The metabolism of intravenously administered fat in adult and newborn dogs.


A reinvestigation of the demethylation of mycophenolic acid.


Implications for the British veterinary profession of membership of the European economic community.


Results of trifluperidol therapy.

Results of trifluperidol therapy.


Experimental pneumonia in calves produced by inoculation of mycoplasmas.


Twinning in cattle.

Twinning in cattle.


Ehrlichia canis--the causative agent of a haemorrhagic disease of dogs?


Instrumental conditioning of thalamogenic movements and its dependence on the cerebral cortex.


Thalamogenic movements in cats: their characteristics and dependence on the cerebral cortex.


The effect of "partial reinforcement" on classical and instrumental conditioned reflexes acquired under continuous reinforcement.


The effect of cardiac sympathectomy on inhibitory and excitatory cardiac conditioned reflexes in cats.


Lateralisation of effects of acute extinction of an alimentary instrumental response.


Effects of alimentary reflexes on motor gastric acitivity.


Myeloarchitectonics of the white matter of the sensorimotor cortex in dogs.


Differing effectiveness of auditory quality and location cues in two forms of differentiation learning.


Coronary heart disease--are there differences in racial susceptibility?


Generalized osteoarthrosis in a population sample.


Hong Kong influenza immunologic recapitulation.


Smallpox transmission in Southern Dahomey. A study of a village outbreak.


Cigarette smoking and epidemic influenza.


The primitive erythropoietic series in the chick embryo, studies with the electron microscope.


The structure of the interalveolar septum of the mammalian lung.


Studies on the innervation of the medial meniscus in the human knee joint.


The fine structure of the vasa recta and associated nerves in the rabbit kidney.


Ultrastructural organization and histochemical profile of adult fowl choroid plexus epithelium.


Histology of the oviduct of the leopard frog, Rana pipiens.


Studies on hypoxia. V. Effects of anoxia on developing connective tissue cells in rats.


True hermaphroditism or gonadal intersexuality. Cytogenetic and gonadal analyses of 5 new examples related to 67 known cases studied cytogenetically.


Periodic attacks of lethargy in a baby with ammonia intoxication due to a congenital defect in ureogenesis.


Carbamylphosphate synthetase deficiency in an infant with severe cerebral damage.


Simplified method for diagnosis of Hirschsprung's disease.


Effects of kwashiorkor on cortical and trabecular bone.


Gastric atrophy in childhood.

Gastric atrophy in childhood.


Pilot trial of an infant screening programme for cystic fibrosis: measurement of parotid salivary sodium at 4 months.


Comparison of arterial and arterialized capillary blood in infants with respiratory distress.


Further observations on a pedigree of the oral-facial-digital syndrome.


Urinary potassium excretion in newborns with and without icterus neonatorum.


Congenital (erythroid) hypoplastic anaemia: modified expression in males.


Effect of orciprenaline on school absenteeism in asthma.


Fibrin-fibrinogen degradation products in sera of normal infants and children.


Pulmonary alveolar proteinosis in an infant.


Lipoprotein lipase activity in marasmic type of protein-calorie malnutrition.


pH changes in children with burns.

pH changes in children with burns.


Plasma uric acid levels in children.

Plasma uric acid levels in children.


Observations on fat and carbohydrate metabolism in generalized lipodystrophy.


Incorporation of methionine sulphur into cysteine in vitro by fibroblasts deficient in cystathionine synthetase.


Muramidase (lysozyme) excretion in children.


Use of rat fetus in experimental teratology.


Blood viscosity in newborn infant and diagnosis and treatment of hyperviscous states.


Assessment of gestational age in newborn: a practical scoring system.


Human breast milk jaundice; estimation of steroids in milk.


Further studies of motor nerve conduction velocity in newborn infants.


Alterations in volitional alcohol intake produced in rats by chronic intraventricular infusions of acetaldehyde, paraldehyde or methanol.


Effect of several diuretics on autoregulation of renal blood flow.


Metabolism of chlorpromazine and related psychotropic drugs in the isolated perfused rat liver.


The effects of graded doses of phenoxybenzamine on the vascular and capsular responses of the isolated, blood-perfused dogs spleen to sympathetic nerve stimulation and catecholamines.


The mechanism of action of streptomycin on hepatic glucose-6-P-NADP-oxido-reductase (G6PDH) activity.


Influence of adrenalectomy on the recovery of norepinephrine levels following guanethidine and metaraminol.


Metabolic effects of oxotremorine.

Metabolic effects of oxotremorine.


The effect of SK&F 525-A, 2-diethylaminoethyl-2,2-diphenylvalerate hydrochloride, on the in vivo metabolism of beta-(0-toloxy)-1,2-propanediol.


Ultrastructural changes in heart muscle after hemorrhagic shock and isoproterenol infusions.


Behavioural action and tranquillizing effect of reserpine, diazepam and hydroxyzine.


Effects of alkylmethoxybenzene and alkylmethylenedioxybenzene essential oils on pentobarbital and ethanol sleeping time.


Further study of the anti-inflammatory mode of action of p-butoxyphenylacethydroxamic acid (CP 1044 J3) in the rat.


The role of anoxia and hypercarbia in induced hypersusceptibility to barbital.


EEG and behavioral effects of 2-5-methoxy-4-methyl-amphetamine (DOM, STP).


The influence of propranolol on cardiovascular function in conscious and anaesthetized horses.


Purification and properties of 6-phosphogluconate dehydrogenase from sheep liver. A method is described for the isolation of 6-phosphogluconate dehydrogenase from sheep liver. The product appears to be homogeneous in polyacrylamide-gel electrophoresis and in sedimentation-velocity and sedimentation-equilibrium studies in the ultracentrifuge. The molecular weight is estimated as 129000 from equilibrium sedimentation.


Biosynthesis of ethylene. 4-methylmercapto-2-oxobutyric acid: an intermediate in the formation from methionine. The enzyme responsible for the conversion of methionine into a precursor of ethylene in cauliflower florets is a transaminase. The formation of 4-methyl-mercapto-2-oxobutyric acid by this enzyme has been shown. The oxo acid stimulates the synthesis of ethylene when added to floret tissue, and tracer experiments have shown that (14)C is incorporated into ethylene from the labelled oxo acid. The evidence is consistent with the view that the oxo acid is an intermediate in the formation of ethylene from methionine.


Inhibitory effects of pH5 enzyme from non-lactating bovine mammary gland on various stages of protein synthesis in the rat liver amino acid-incorporating system. 1. pH5 enzyme from non-lactating bovine mammary gland was found to contain potent inhibitors of protein synthesis in the rat liver cell-free system. These inhibitors affect (a) formation of aminoacyl-tRNA where tRNA represents transfer RNA, (b) transfer of labelled amino acids from rat liver amino[(14)C]acyl-tRNA to protein in rat liver polyribosomes, and (c) incorporation of (14)C-labelled amino acids into peptide by rat liver polyribosomes supplemented with rat liver pH5 enzyme. 2. Increasing amounts of pH5 enzyme from bovine mammary gland progressively inhibited the incorporation of labelled amino acids into protein by a complete incorporating system from rat liver. Approx. 80% inhibition was observed at a concentration of 2mg. of protein of pH5 enzyme from bovine mammary gland. The inhibitory effect of the bovine pH5 enzyme fraction could not be overcome by the addition of increasing amounts of rat liver pH5 enzyme. 3. Fractionation of bovine pH5 enzyme with ammonium sulphate into four fractions showed that all the fractions inhibited the incorporation of (14)C-labelled amino acids in the rat liver system, but to varying extents. The highest inhibition observed (90%) was exhibited by the 60%-saturated-ammonium sulphate fraction. 4. Heat treatment of bovine pH5 enzyme at various temperatures caused only a partial loss of its inhibitory effect on labelled amino acid incorporation by the rat liver system. Treatment at 105 degrees for 5min. resulted in the bovine pH5 enzyme fraction losing 30% of its inhibitory activity. 5. pH5 enzyme from bovine mammary gland strongly inhibited the charging of rat liver tRNA in the presence of its own pH5 enzymes. 6. The transfer of labelled amino acids from rat liver amino[(14)C]acyl-tRNA to protein in a system containing rat liver polyribosomes and pH5 enzyme was almost completely inhibited by bovine pH5 enzyme at a concentration of 2mg. of protein of the enzyme fraction. 7. One of the inhibitors of various stages of protein synthesis in rat liver present in bovine pH5 enzyme was identified as an active ribonuclease, and the second inhibitor present was shown to be tRNA.


Studies on the permeability of rat liver lysosomes to carbohydrates. 1. The latency of nitrocatechol sulphatase activity was measured in rat liver lysosomes before and after preincubation in 0.25m solutions of 25 different carbohydrates. 2. Preincubation in disaccharides, hexitols, gluconate, glucuronate or lactate gave little or no rise in ;free' sulphatase activity, indicating that these compounds do not easily penetrate the lysosomal membrane, but incubation in monosaccharides or the lower glycitols caused a progressive loss of latency. 3. Rates of increase in ;free' activity were taken as an indication of rates of solute penetration into lysosomes and were correlated with the structure and molecular weight of each sugar. 4. Additional evidence for non-penetration of maltose was obtained by demonstrating that the latency of lysosomal alpha-glucosidase is independent of substrate concentration employed. 5. The results are discussed in the light of published data on the latency of lysosomal enzymes.


The importance of life-time changes in fluorescence depolarization. The rotational relaxation time, rho, calculated from measurements of fluorescence depolarization, is clearly dependent on the assumed mean life-time, tau, of the excited state. However, variations in tau with experimental conditions (temperature and solvent composition) occur and the effect of such alterations in tau is demonstrated. In particular it should be noted that, unless life-time changes can be excluded, the occurrence of linear plots of reciprocal degree of polarization against the temperature/viscosity ratio does not necessarily indicate the absence of intramolecular freedoms. An attempt to correct for such life-time changes by measurement of the fluorescence intensity is made for the bovine serum albumin-1-dimethyl-aminonaphthalene-5-sulphonyl chloride system. The value of rho/3tau thus obtained for this system at 20 degrees is approx. 4.7, as against approx. 3.4 obtained by several workers in the absence of life-time corrections.


Acid-catalysed dehydration of dehydroretinol. 1. Treatment of dehydroretinol with hydrogen chloride in light petroleum or toluene-p-sulphonic acid in benzene produces a substance with u.v.-absorption maxima at 284, 296, 310, 350, 368, 388, 408 and 433nm. and antimony trichloride colour maximum at 620nm. This compound is tentatively named compound 433 after its absorption maximum at 433nm. 2. Treatment of dehydroretinol with ethanolic hydrogen chloride produces, besides 3-ethoxyanhydroretinol, some compound 433 also. 3. Compound 433 is present in several freshwater-fish liver oils. 4. The i.r. spectrum of compound 433 shows only a band attributable to a conjugated ethylenic system. 5. The course of changes that lead to the formation of compound 433 is discussed.


The enzymic degradation of ovalbumin and its glycopeptides. 1. Ovalbumin glycopeptides, freed from all amino acids other than aspartic acid and a small proportion of leucine by repeated digestion with Pronase, were hydrolysed by 1-aspartamido-beta-N-acetylglucosamine amidohydrolase (glycoaspartamidase) to the corresponding oligosaccharides. The glycoaspartamidase did not attack ovalbumin itself. 2. Ovalbumin, with mannose/hexosamine ratio 5:4, lost 1.5moles of N-acetylglucosamine and more than 2moles of mannose after incubation with alpha-mannosidase and beta-N-acetylglucosaminidase respectively. 3. In ovalbumin glycopeptides with approximate mannose/hexosamine ratios 5:3 and 5:4, one and two N-acetylglucosamine residues respectively were accessible to the action of beta-N-acetylglucosaminidase. 4. A mixture of alpha-mannosidase and beta-N-acetylglucosaminidase, acting on an ovalbumin glycopeptide with mannose/hexosamine ratio 5:3.7, removed nearly 4moles of mannose and 1.5moles of N-acetylglucosamine. 5. alpha-Mannosidase removed about 1.5moles of mannose from the ovalbumin oligosaccharide with mannose/hexosamine ratio approx. 5:3. The subsequent action of beta-N-acetylglucosaminidase liberated less than 1mole of N-acetylglucosamine and made at least 1mole further of mannose accessible to alpha-mannosidase action. 6. It is concluded that the carbohydrate moiety of ovalbumin is linked through a glycosyl group to asparagine. In a molecule with mannose/hexosamine ratio 5:4, there are two beta-N-acetylglucosamine residues linked together in a terminal position, followed by alpha-mannose. There is also present a side chain containing two alpha-mannose units.


Cytoplasmic effects of cortisol in liver. 1. The time-course of the induction by cortisol of tryptophan pyrrolase in mouse liver was established. 2. The kinetics of labelling of mouse liver polyribosomes and the distribution of radioactivity in the various sizes of polyribosomes were investigated. It is concluded that the major part of the messenger RNA is monocistronic. 3. Cortisol administered to adrenalectomized mice stimulates in parallel the ability of ribosomes and polyribosomes, both free and bound, to incorporate amino acids into protein. 4. This stimulation does not appear to affect in a selective manner particular regions of the gradients of polyribosomes. 5. Administration of cortisol enhances the ability of the denser fraction of the rough microsomes to incorporate labelled amino acids. Adrenalectomy has minor effects on the pool sizes and specific radioactivities of liver amino acids which are counteracted by the hormone. However, these appear insufficient to influence the changes observed. 6. Adrenalectomy causes an increase in the percentage of ribosomes existing as polyribosomes and a fall in the proportion bound to the membrane of the endoplasmic reticulum. After treatment of these animals with cortisol there is a marked increase in the proportion of bound ribosomes. 7. The influence of cortisol on the membranous components of liver cytoplasm is discussed.


Studies on flavonoid metabolism. Metabolism of (+)-[14C] catechin in the rat and guinea pig. 1. The fate of (+)-[U-(14)C]catechin and (+)-[ring A-(14)C]catechin has been studied in the guinea pig and rat. 2. (+)-[U-(14)C]Catechin was shown to give rise to labelled phenolic acids, labelled phenyl-gamma-valerolactones and (14)CO(2). 3. (+)-[ring A-(14)C]-Catechin did not give rise to labelled phenolic acids, but labelled phenyl-gamma-valerolactones were detected together with a higher proportion of (14)CO(2). 4. Administered [(14)C]delta-(3-hydroxyphenyl)-gamma-valerolactone gave rise to labelled m-hydroxyphenylpropionic acid in the rat whereas administered [(14)C]m-hydroxyphenylpropionic acid gave rise to a compound yielding labelled m-hydroxybenzoic acid on hydrolysis. 5. The distribution of radioactivity in the urine and faeces of (+)-[(14)C]catechin-fed animals is described; a high proportion of residual radioactivity was found in urine that had been exhaustively extracted with diethyl ether.


Disequilibrium in the triose phosphate isomerase system in rat liver. 1. The equilibrium constant at 38 degrees and I 0.25 of the triose phosphate isomerase reaction was found to be 22.0 and that of the aldolase reaction, 0.99x10(-4)m. The [dihydroxyacetone phosphate]/[glyceraldehyde phosphate] ratio was found to be 9.3 in rat liver. The causes of the apparent deviation of the triose phosphate isomerase system from equilibrium in vivo have been investigated. 2. The equilibria of the triose phosphate isomerase and aldolase reactions were studied with relatively large concentrations of crystalline enzymes and small concentrations of substrates, approximating to those found in rat liver and muscle. There was significant binding of fructose diphosphate by aldolase under these conditions. There was no evidence that binding of glyceraldehyde phosphate by either enzyme affected the equilibria. 3. The deviation from equilibrium of the triose phosphate isomerase system in rat liver can be accounted for by the low activity of the enzyme, in relation to the flux, at low physiological concentrations of glyceraldehyde phosphate (about 3mum). It has been calculated that a flux of 1.8mumoles/min./g. wet weight of liver would be expected to cause the measured degree of disequilibrium found in vivo. 4. The conclusion that the triose phosphate isomerase is not at equilibrium is in accordance with the situation postulated by Rose, Kellermeyer, Stjernholm & Wood (1962) on the basis of isotope-distribution data. 5. The triose phosphate isomerase system is closer to equilibrium in resting muscle probably because of a very low flux and a high enzyme concentration. 6. The aldolase system deviated from equilibrium in rat liver by a factor of about 10 and by a much greater factor in resting muscle. 7. The measurement of total dihydroxyacetone phosphate and glyceraldehyde phosphate content indicates the concentrations of the free metabolites in the tissue. This may not hold for fructose diphosphate, a significant proportion of which may be bound to aldolase.


Stimulation of incorporation of nucleic acid precursors into HeLa cells caused by proflavine. 1. The effect of proflavine and other acridines on the incorporation of precursors into the nucleic acids of HeLa cells was examined. 2. Relatively low concentrations (50mum) of proflavine completely inhibited incorporation of precursors into DNA, but allowed a small extent of incorporation into RNA. 3. Acridine-resistant incorporation into RNA was unaffected by actinomycin D at 2mug./ml. and persisted even at high concentrations (500mum) of many acridines. 4. A few combinations of acridine and precursor, notably 250mum-proflavine and [(14)C]adenine, caused a stimulation of incorporation. 5. The proflavine-stimulated incorporation was into alkali-stable di- and tri-nucleotides. 6. It was concluded that the effect was due to the preferential inhibition of degradation of a fraction of RNA that normally turned over, thus allowing small radioactive oligonucleotides to accumulate in the cells.


Hepatic collagenolytic activity in rats after carbon tetrachloride poisoning. 1. Collagenolytic activity towards acid-soluble collagen labelled with [(14)C]-proline was assayed in rat liver with and without carbon tetrachloride poisoning. The products of enzymic digestion were found to be free amino acids and peptides. 2. The hepatic collagenolytic activity increased under conditions of single-dose and subacute carbon tetrachloride poisoning, and correlated with hydroxyproline content. The highest activity was found during recovery from subacute poisoning. 3. Under the same experimental conditions, hepatic acid-proteinase activity changed independently of the collagenolytic activity and also of hepatic hydroxyproline content. 4. The increased collagenolytic activity during carbon tetrachloride poisoning was found mainly in the supernatant fraction. 5. The ratio of the collagenolytic activity to hepatic hydroxyproline content increased during recovery from single-dose and subacute poisoning, and decreased during subacute poisoning.


The stereochemistry of hydrogen elimination at C-7,C-22 and C-23 during the conversion of cholesterol (cholest-5-en-3 beta-ol) into cholesta-5,7,22-trien-3 beta-ol by Tetrahymena pyriformis.


Comparison of the abilities of free and membrane-bound polyribosomes isolated from exponential-phase cells of Bacillus amyloliquefaciens to incorporate amino acids into protein.


Molecular aspect of action of endogenous erythropoietin. The effects of erythropoietic stimuli on synthesis of ribonucleic acids in rabbit bone marrow.


Minor dinocleotides of rat-liver transfer RNA.


Isolation of mammalian transfer RNA.

Isolation of mammalian transfer RNA.


On the mechanism of erythropoietin-induced differentiation. VI. Induced accumulation of iron by marrow cells.


Amino acid pools in rat parotid gland during epinephrine-stimulated protein synthesis.


Photosensitization of skin in vivo by furocoumarins (psoralens).


Protein synthesis in small intestine: localization and correlation with DNA synthesis and sucrase activity.


Fractionation of nuclei from Paramecium aurelia by density gradient centrifugation.


Nuclease-protected RNA segments in rat liver ribosomes.


Studies on the RNA polymerase-histone complexes.


Ethidium bromide and chloroquine inhibition of rat liver cell-free aminoacylation.


The effects of acidic proteins and RNA on the histone inhibition of the DNA-dependent RNA synthesis in vitro.


Synthesis of the 60-S ribosomal subunit in yeast.


Liver lysosomes in protein-starved rats.


Effects of supplementing ragi (Eleusine coracana) diets with lysine or leaf protein on the growth and nitrogen metabolism of children.


Some effects of starch on protein utilization by sheep.


The effect of heat treatment on the nutritive value of milk for the young calf. 8. The effect of the pre-heating treatment of spray-dried skim milk on the pH and the contents of total, protein and non-protein nitrogen of the pyloric outflow.


The relationship between an elevated serum amino acid ratio and the development of other biological abnormalities in the experimentally malnourished pig.


Chemical composition of organs of children who died from malnutrition.


The rumen buffering system of sheep fed pelleted roughage-concentrate rations.


Growth rates in children recovering from protein-calorie malnutrition.


Stomach function in relation to a scour syndrome in the piglet.


Differences in the metabolism of esterified and unesterified linoleic acid by rumen micro-organisms.


Mechanisms of heat damage in proteins. 1. Models with acylated lysine units.


The urinary excretion of metabolites of riboflavine by man.


Time relationships between the elevation of the serum  amino acid ratio and changes in liver composition in malnourished rats.


Calcium balance studies on children accustomed to low calcium intakes.


The uptake and metabolism of retinol, retinoic acid and methyl retinoate by the early chick embryo.


Nutritive value of proteins of pearl millet of high-yielding varieties and hybrids.


The effect of protein-calorie malnutrition on the composition of the human femur.


The protein binding of acetylsalicylic acid and salicylic acid.


Analytical bias in a quality control scheme.


A bubble-gating flow cell for continuous-flow analysis.


A semiquantitative screening test and quantitative assay for total fecal fat.


Fermentation of various soluble carbohydrates by rumen micro-organisms with particular reference to methane production.


A modified semi-automated resorcinol method for the determination of inulin.


A cleaning technic for mercury in the clinical laboratory.


A procedure for the measurement of urinary 17-hydroxycorticosteroids, aldosterone acid-labile conjugate, and free plasma cortisol in patients with chronic illness.


Aldolase determination.

Aldolase determination.


The intestinal absorption of scopolamine-N-butylbromide (Buscopan) from isolated loops in conscious rats.


Pharmacological studies on teleost melanophores.


Effects of morphine on cat brain norepinephrine in regions with daily monoamine rhythms.


Distribution of tritium-labelled tofenacine hydrochloride in the pregnant mouse.


The effect of hypoxia on cardiac tissue. I. High energy phosphates content and oxygen uptake.


Improvement of blood circulation in experimental skin flaps by phentolamine.


The pharmacological effects of selectively released hydrogen cyanide.


The effect of St 155 on the active reflex vasodilatation induced by adrenaline, noradrenaline and veratrine.


Effects of sotalol and propranolol administered orally in man.


Uptake and accumulation of 3H-noradrenaline in adrenergic nerves of rat iris. Effect of reserpine, monoamine oxidase and tyrosine hydroxylase inhibition.


Studies of tolerance development to morphine analgesia in rats tested on the hot plate.


Comparative acetoacetylation of proteins.


Anaesthetic properties of some esters of 2-piperidylcarbinols.


A new guanidine alkaloid.

A new guanidine alkaloid.


Synthesis and biological activity of 9-alpha-hydroxy-11 beta-nitro-1,3,5(10)-estratrienes: a new class of potent estrogenic steroids.


The effect of oxygen concentration on the quantum yields of the dye-sensitized photoinactivation of trypsin, alpha-chymotrypsin and lysozyme.


Effect of aflatoxin B1 on the incorporation of 14C-acetate into cholesterol by rat liver.


Properties of RNA containing bacteriophage f4.


Protein synthesis in isolated, beating rat atria.


Studies on relationships between riboflavin and folate.


Microbial degradation of aliphatic branched compounds: isobutyric, 2,2-dimethylmalonic and 2,2-dimethylsuccinic acids.


Glucose-6-phosphate dehydrogenase activity in the mucosa and musculature of the duodenum and stomach of rats with alimentary-conditioned reflex.


Aging in relation to auxin and RNA.

Aging in relation to auxin and RNA.


The interaction of protamine with human blood plasma proteins.


Nucleoside aminohydrolase, an enzyme involved in the degradation of deoxycytidine.


Recording and analysis of sounds produced by human lungs during respiration.


Metabolism of the sulphur amino acids in Stegobium paniceum L. and Lasioderma serricorne F.


Biochemical characteristics of yeast respiration-deficient mutants differing in buoyant densities of mitochondrial DNA.


Histochemical mapping of motor units in experimentally re-innervated skeletal muscle.


Tension and structure in crustacean fast and slow muscle fibers.


The effect of NaCl on the peristalsis of the isolated guinea pig ileum.


The part played by temperature in the rhythm of formation of markings on the shell of cuttlefish (Sepia officinalis L.) (Cephalopoda, Mollusca).


Comparison of the effects of atropine sulfate and procaine hydrochloride on nerve conduction.


An effect of pyridoxal-5'-phosphate on the strength of skin in vitro.


The effects of prostaglandin E1 on the systemic and pulmonary circulations of intact dogs. The influence of urethane and pentobarbital anesthesia.


A trypsin-like protease in guinea pig skin.


2,6-Dichlorobenzylidene amino guanidine acetate (Wy-8678). A new hypotensive agent.


Electron microscopic observations on the granular vesicles in the ciliary ganglion of the rat.


Variation of thickness of glomerular basement membrane in various experimental circumstances.


Effect of 17-beta-estradiol on early cleavage patterns in the embryo of Fucus distichus.


Intracellular localization of acid phosphatase and aryl sulfatase in rat metrial gland cells.


Catecholamines in the avian carotid body.


Activities of cystathionase, cysteine sulphinic acid decarboxylase and serine dehydrase in the liver of tumour-bearing rats.


Anti-N from Moluccella laevis.

Anti-N from Moluccella laevis.


Specific and non-specific immunoglobulin synthesis in germfree mice immunized with ferritin by different routes.


Studies on lysosomes in rat heart cell cultures. II. The effect of exogenous lysosomes.


A note on the neurosecretory pathways in Pyrilla perpusilla Walker (Fulgoridae: Homoptera).


Anti-hapten antibodies in the serum and bronchial secretions of dogs following respiratory tract immunization.


Oxygen consumption of genetically obese rats.


Hemodynamic changes in rats without adrenal medulla submitted to hypovolemic shock.


The inhibitory effects of anti-androgen (SH-714) on erythropoietic activity.


Transferrin types in Indian water buffalo (Bos bubalis).


Some aspects of complementation with carotenogrenic al loci in Neurospora crassa.


Phosphoglucomutase polymorphis in the rainbow trout, Salmo gairdneri.


The genetics of a soluble acidic protein in skeletal muscle.


Purothionins in Aegilops-Triticum spp.

Purothionins in Aegilops-Triticum spp.


Complement with 38 chromosomes in 2 South Anerican populations of Rattus rattus.


Properties of mycobacteriophage C2.

Properties of mycobacteriophage C2.


Influence of recurrent nerve severance on haemolymph proteins in Periplaneta americana L.


Liquid scintillation counting medium for aqueous samples.


Susceptibility of new born and adult laboratory animals to Chikungunya virus.


Studies with Chikungunya virus. I. Susceptibility of birds and small mammals.


Enzymatic studies in alloxan-diabetes.

Enzymatic studies in alloxan-diabetes.


Effect of sodium salt of glucose-cyclo acetoacetate (Na-GCA) and its hydrolysate (GCAh) on bile secretion in dogs.


Pathogenic intestinal organisms in the unfiltered water supply of Calcutta and the effect of chlorination.


A comparison of salt-floatation and formol-ether techniques in demonstrating helminthic ova in faeces.


Vibrio fetus encephalitis with bacteremia in a child.


The Arizona group of organisms in the aetiology of childhood diarrhoea.


Studies on serum protein requirement of mouse fibrosarcoma cells cultured in vitro.


A simplified method for the measurement of tritium, carbon-14 and calcium-45 concentrations in blood plasma.


Disaccharide intolerance and Indian childhood cirrhosis. II. Survey of the families for maltosuria.


The differential modification of the blood pressure responses to some of the sympathomimetic agents by bivalent metallicions on dog blood pressure.


Investigations into the causation of increased susceptibility of diabetics to cutaneous infections.


Investigations to study the nature of urinary constituents in women with uterine fibroids.


A new colorimetric method for the estimation of serum non-esterified fatty acids.


Viral hepatitis. An analysis of notifications received from an army command during June 1966 to December 1967.


Blood carboxyhemoglobin level in Beedi smokers.


Hemolytic streptococci and immune response in children with rheumatic fever.


An epidemiological study of endemic fluorosis in Punjab.


Replacement of the ureter by autogenous vein graft.


Results of treatment of hip disorders with cup arthroplasty.


Arthroplasty of the knee. A follow-up study of fifty-four cases treated by operative reconstruction of the sliding apparatus in the stiffened knee.


Tibial osteotomy in gonarthrosis (osteo-arthritis of the knee).


Aspiration biopsy of the spine. Technique for the thoracic spine and results of twenty-eight biopsies in this region and over-all results of 1050 biopsies of other spinal segments.


Anterior interosseous-nerve paralysis as a complication of supracondylar fractures of the humerus in children.


The turnover of adult rabbit articular cartilage.


The functions of the muscles of the thumb, the index, and long fingers. Synchronous recording of motions and action potentials of muscles.


Anterior occipito-cervical fusion using an extra-pharyngeal exposure.


Bilateral posterior fracture-dislocation of the shoulder. A case report.


Evolution of a post-fracture cyst of the fibula.


Extra-abdominal desmoid of the hand. A case report.


The extensor indicis proprius syndrome.

The extensor indicis proprius syndrome.


Sequential roentgenographic changes occurring in massive osteolysis.


A diagnostic sign in fourth and fifth lumbar disc surgery. The so-called jerk reflex.


A force-indicating distractor for the Harrington-rod procedure.


A femoral head measuring device.

A femoral head measuring device.


Studies on the active transport of calcium in human red cells. The Ca(++) transport mechanism in the red cell membrane was studied in resealed ghost cells. It was found that the red cell membrane can transport Ca(++) from inside the cell into the medium against great concentration gradient ratios. Tracing the movement of (45)Ca infused inside red cells indicated that over 95% of all Ca(++) in the cells was transported into media in 20 min incubation under the optimum experimental conditions. The influence of temperature on the rate constant of transport indicated an activation energy of 13,500 cal per mole. The optimum pH range of media for the transport was between 7.5 and 8.5. As energy sources, ATP(1), CTP, and UTP were about equally effective, GTP somewhat less effective, and ITP least effective among the nucleotides tested. The Ca(++) transport does not appear to involve exchange of Ca(++) with any monovalent or divalent cations. Also, it is not influenced by oligomycin, sodium azide, or ouabain in high concentrations, which inhibit the Ca(++) transport in mitochondria or in sarcoplasmic reticulum. In these respects, the Ca(++) transport mechanism in the red cell membrane is different from those of mitochondria and the sarcoplasmic reticulum.


Current- and voltage-clamped studies on Myxicola giant axons. Effect of tetrodotoxin. A new dissection procedure for preparing Myxicola giant axons for observation under voltage clamp is described. Preparation time is generally 40-45 min. 65-70% of the preparations attempted may be brought through the entire procedure, including insertion of the long internal electrode, and support an initial action potential amplitude of 100 mv or greater. Mean values for axon diameter, resting membrane potential, action potential amplitude, maximum peak inward transient current, and resting membrane resistance are 560 micro, -66.5 mv, 112 mv, 0.87 ma/cm(2) and 1.22 K ohm cm (2) respectively. Cut branches do not seem to be a problem in this preparation. Behavior under voltage clamp is reasonably stable over several hours. Reductions in maximum inward transient current of 10% and in steady-state current of 5-10% are expected in the absence of any particular treatment. Tetrodotoxin blocks the action potential and both the inward and outward transient current, but has no effect on either the resting membrane potential or the steady-state current. This selective action of tetrodotoxin on the transient current is taken as an indication that this current component is probably carried by Na.


Current separations in Myxicola giant axons. The effect of reducing the external sodium concentration, [Na](o), on resting potential, action potential, membrane current, and transient current reversal potential in Myxicola giant axons was studied. Tris chloride was used as a substitute for NaCl. Preliminary experiments were carried out to insure that the effect of Tris substitution could be attributed entirely to the reduction in [Na](o). Both choline and tetramethylammonium chloride were found to have additional effects on the membrane. The transient current is carried largely by Na, while the delayed current seems to be independent of [Na](o). Transient current reversal potential behaves much like a pure Nernst equilibrium potential for sodium. Small deviations from this behavior are consistent with the possibility of some small nonsodium component in the transient current. An exact P(Na)/P(K) for the transient current channels could not be computed from these data, but is certainly well greater than unity and possibly quite large. The peak of the action potential varied with [Na](o) as expected for a sodium action potential with some substantial potassium permeability at the time of peak. Resting membrane potential is independent of [Na](o). This finding is inconsistent with the view that the resting membrane potential is determined only by the distribution of K and Na, and P(Na)/P(K). It is suggested that P(Na)/P(K)'s obtained from resting membrane potential-potassium concentration data do not always have the physical meaning generally attributed to them.


Membrane characteristics of the canine papillary muscle fiber. Passive and active responses to intracellular and extracellular stimulation were studied in the canine papillary muscle. The electrotonic potential produced by extracellular polarization with the partition chamber method fitted the time course and the spatial decay expected from the cable theory (the time constant, 3.3 msec; the space constant, 1.2 mm). Contrariwise, spatial decay of the electrotonic potentials produced by intracellular polarization was very short and did not fit the decay curve expected for a simple cable, although only a small difference of time course in the electrotonic potentials produced by intracellular and extracellular polarizations was observed. A similar time course might result from the fact that when current flow results from intracellular polarization, the input resistance is less dependent on the membrane resistance. The foot of the propagated action potential rose exponentially with a time constant of 1.1 msec and a conduction velocity of 0.68 m/sec. The membrane capacity was calculated from the time constant of the foot potential and the conduction velocity to be 0.76 microF/cm(2). The responses of the papillary muscle membrane to intracellular stimulation differed from those to extracellular stimulation applied with the partition method in the following ways: higher threshold potential, shorter latency for the active response, linearity of the current-voltage relationship, and no reduction in the membrane resistance at the crest of the action potential during current flow.


Leak current rectification in Myxicola giant axons. Constant field and constant conductance components. Early leak current, i.e. for times similar to the time to peak of the transient current was measured in Myxicola giant axons in the presence of tetrodotoxin. The leak current-voltage relation rectifies, showing more current for strong depolarizing pulses than expected from symmetry around the holding potential. A satisfactory practical approximation for most leak corrections is constant resting conductance. The leak current-voltage curve rectifies less than expected from the constant field equation. These curves cannot be reconstructed by summing the constant field currents for sodium and potassium using a P(Na)/P(K) ratio obtained in the usual way, from zero current constant field fits to resting membrane potential data. Nor can they be reconstructed by summing the constant field current for potassium with that for any other single ion. They can be reconstructed, however, by summing the constant field current for potassium with a constant conductance component. It is concluded that the leak current and the resting membrane potential, therefore, are determined by multiple ionic components, at least three and possibly many. Arguments are presented suggesting that ion permeability ratios obtained in the usual way, by fitting the constant field equation to resting membrane potential data should be viewed with skepticism.


The physiological role of the lymphoid system.


A study of medical manpower in Lebanon.

A study of medical manpower in Lebanon.


Effect of ethyl alcohol on sperm transport in the rabbit.


Energy conversion in bull sperm flagella. With the use of a specially developed incubation chamber the rates of motility, respiration, and fructolysis were measured simultaneously on semen samples. By inhibiting the respiration with antimycin A, and/or the fructolysis with 2-deoxyglucose, the rates of each of the two ATP-producing pathways could be reduced independently. In this way the ratio of the amount of free energy produced by respiration and by fructolysis could be varied at will from 1 to 0. In uninhibited preparations approximately 75% of the free energy derives from respiration, and 25% from fructolysis. By the use of the absolute rates of respiration, fructolysis, and motility, the efficiency of the conversion of free energy into hydrodynamic work was calculated. After correction for the decay of the preparation during the experiment, this conversion efficiency was found to be 30-45% lower for free energy from respiration than for free energy from fructolysis. The difference in distribution of the enzymes for fructolysis and respiration over the flagellum was ruled out as the cause of the efficiency difference. The respiration could be 70% inhibited by oligomycin. It is concluded that approximately one-third of the free energy from respiration is used for maintenance of the mitochondria.


Pituitary dwarfism.

Pituitary dwarfism.


Recurrent hydatidiform mole: a report of five cases with review of the literature.


Molecular localization of frog retinal receptor photopigment by electron microscopy and low-angle X-ray diffraction.


Planar liquid-like arrangement of photopigment molecules in frog retinal receptor disk membranes.


Relation between allosteric effects and changes in the energy of bonding between molecular subunits.


Possible allosteric effects in extended biological systems.


Extension of the theory of linked functions to incorporate the effects of protein hydration.


Molecular weights of some HeLa ribosomal RNA's.


Attachment of tail fibers in bacteriophage T4 assembly: some properties of the reaction in vitro and its genetic control.


Conformation of the high pH form of chymotrypsin.


The process of infection with bacteriophage phiX174. XXVI. Transfer of the parental DNA of bacteriophage phiX174 into progeny bacteriophage particles.


Urea and thiourea permeabilities of phospholipid and cholesterol bilayer membranes.


A double-helical structure found on the re-aggregation of the protein of barley stripe mosaic virus.


The process of infection with bacteriophage phiX174. XXVII. Synthesis of a viral-specific chloramphenicol-resistant protein in phiX174-infected cells.


Changes in heme environment due to subunit interaction in hemoglobin.


DNA replication in head mutants of bacteriophage lambda.


Analysis of sweat gland responses to intradermal injections of acetylcholine.


The effects of acclimatization to heat on evaporative cooling from high body temperatures in man.


The water economy of desert aboriginals in summer.


Kinetics of two-carrier transfer.

Kinetics of two-carrier transfer.


Choline transport by the small intestine.


Efferent and afferent impulse activity in the "intact" sinus nerve.


A high impedance Field Effect Transistor input stage with good d.c. stability.


The molar ratio of calcium to magnesium in the shell of the hen's egg during formation.


Protein secretion by the magnum region of the oviduct of the hen.


The control of plasma uric acid levels in the domestic fowl.


The effect of anaesthesia on the somatosensory cortex of the rat.


Influence of carotid baroreceptors on different components of the vascular system. 1. Reflex changes in wall tension of the lateral saphenous vein of one hind limb, the splenic veins and capsule, and the resistance vessels of the other hind limb caused by changes in baroreceptor activity were measured in vagotomized dogs under thiopentone-chloralose anaesthesia.2. Three different methods were used to alter pressure in one or both carotid sinuses. (1) Both carotid sinuses were vascularly isolated and filled with fully oxygenated Krebs-Ringer bicarbonate solution (pH 7.4) from a reservoir in which the pressure could be altered at will. (2) One sinus was denervated, and the contralateral sinus was perfused with arterial blood at different flow rates. (3) One sinus was denervated, and the innervated sinus was perfused with arterial blood at constant flow, the pressure being altered by changing the outflow resistance.3. The left saphenous vein was perfused at constant flow with autologous blood; changes in perfusion pressure were used as a measure of changes in veno-motor activity. The right common iliac artery was perfused at constant flow to measure changes in resistance vessel activity. Blood flow through the spleen was temporarily arrested, trapping a fixed volume of blood in the organ. Under these conditions, changes in splenic vein pressure were a measure of changes in smooth-muscle tension in the splenic capsule and veins.4. In order to assess the responses to baroreceptor stimulation in terms of alterations in sympathetic nerve traffic to different components of the peripheral vascular system, ;frequency-response curves' were constructed for spleen, saphenous vein, and limb resistance vessels by electrical stimulation of the splenic nerves and lumbar sympathetic chains.5. The saphenous vein showed no consistent response to changes in baroreceptor activity. Reduction in carotid sinus pressure from 180 to 100 mm Hg caused an increase in venous pressure in the isovolumetric spleen and in the iliac artery perfusion pressure. These results were confirmed by electrical stimulation of the carotid sinus nerve. Whereas the peak responses of the limb resistance vessels corresponded to an increase in lumbar sympathetic nerve traffic of 6-10 c/s, the maximal splenic responses were equivalent to an increase in splenic nerve traffic of 1-4 c/s. These results are consistent with selective autonomic nervous control of different components of the peripheral vascular system.


The role of the antrum and the vagus nerve in the formation of gastric mucosal histamine. 1. The effects of the vagus nerve and of antral gastrin on the rate of histamine formation (histamine forming capacity, HFC, i.e. histidine decarboxylase activity) in the parietal cell region of the gastric mucosa has been investigated in the following stomach preparations: gastric fistula, denervated Heidenhain pouch, antral resection with gastrojejunostomy, gastrojejunostomy with exclusion of the duodenum and in the intact stomach. The determinations of mucosal HFC were made on fasting rats and on re-fed animals when the effect of feeding was studied.2. In fasting rats with a gastrojejunostomy and the antrum intact the mucosal HFC of the innervated stomach was about 4 times higher than in the corresponding preparation with the antrum resected. In the innervated main stomach the mucosal HFC was about twice as high as in the denervated pouch, indicating that the vagus and endogenous antral gastrin each contribute to maintaining mucosal HFC in the fasting state.3. Acidifying the stomach caused a substantial lowering of the mucosal HFC presumably by inhibiting antral gastrin release, whereas acid in the stomach did not interfere with the elevation of mucosal HFC evoked by injection of gastrin.4. Injection of gastrin elevated mucosal HFC in the innervated main stomach and in the denervated pouch to approximately equal levels. With the dose of gastrin employed there was about a fourfold increase in the HFC of the pouch mucosa.5. In antrectomized rats enhanced vagal influence, evoked by insulin injection or by feeding, raised the mucosal HFC. In rats with the antrum intact and the stomach acidified, insulin injection produced an increased HFC. Thus, a vagal effect on mucosal HFC exists independent of participation of antral gastrin.6. The stable choline esters carbachol and methacholine act directly on the parietal cell without involving mucosal HFC. The vagus nerve and gastrin, however, are assumed to provide secretory stimulation by means of accelerated histamine formation.7. The interrelation between increased histamine formation and hydrochloric acid secretion is discussed.


Velocity of ventricular depolarization of the human heart determined from the QRS loop of the vectorcardiogram.


Fidelity of information transfer in a vestibular afferent pathway.


Arterial wall vibration distal to stenoses in isolated arteries.


The effect of acute changes in haematocrit in the anaesthetized dog on the volume and character of the urine. 1. Acute changes in haematocrit were produced by exchange transfusion of dextran-in-saline or packed red cells.2. There were no significant changes in glomerular filtration rate, blood pressure, central venous pressure, heart rate, respiratory rate, blood volume or extracellular fluid volume following the exchange transfusions.3. Urine volume increased after haemodilution but decreased after haemoconcentration.4. The diuresis after haemodilution occurred despite an infusion of ADH or alcohol. Thus it could not be attributed to a change in circulating ADH level.5. There were two types of diuresis. The ;water diuretic' response was characterized by an increase in free water clearance with a reduction in urinary sodium concentration; the ;sodium diuretic' response by an increase in urinary sodium concentration but no change, or a fall, in free water clearance.6. The results were related to changes in medullary osmotic gradient found by other workers to occur when medullary blood flow rate is altered.


Capacitance responses and fluid exchange in the cat liver.


Indirect cholinergic vasomotor control of intestinal blood flow in the domestic chicken. 1. A histochemical and pharmacological study has been made of the relationship between the medial circular and adventitial longitudinal smooth muscle coats of the anterior mesenteric artery of the domestic chicken.2. The longitudinal (LM) coat was found to be innervated by excitatory cholinergic and inhibitory adrenergic nerves, confirming previous reports.3. The circular (CM) coat was found to be innervated by adrenergic vasoconstrictor nerves. There was no evidence for the existence of cholinergic nerves supplying the circular muscle.4. Contraction of the LM had little effect on the resting perfusion pressure of the isolated artery, but caused potentiation of perfusion pressure responses to vasoconstrictor stimuli directly affecting the CM.5. It is suggested that the function of the LM is to modulate the reactivity of the anterior mesenteric artery to vasomotor stimuli, and that this may be particularly implicated in the cardiovascular response to sudden stress.


In vivo determination of electrical properties of canine gastric mucosa.