Prediction of the future position of a moving object.


Avoidance behaviour to light in the protozoa Tetrahymena. The effect of a gradual versus an abrupt boundary between dark and light.


Quantitative psychophysical and electro-physiological data on some odorous compounds.


Dimension analysis of the perception of musical style.


Flat embedding of thin tissues in commercially available polyethylene containers.


The expandable loop: an improved wire-loop device for producing thin photographic films suited to autoradiographic electron microscopy.


A two-level autoradiographic emulsion tank for easy filling and dipping in total darkness.


Surgical aspects of radiation enteritis.


An evaluation of the duration of the surgical scrub.


An experimental shock model simulating clinical hemorrhagic shock.


Large amounts of orally administered barium for obstruction of the small intestine.


Absorption of urinary contents from isolated segments of jejunum and ileum.


Renal artery anastomosis with the Nakayama ring.


Microvascular changes in acutely ischemic rat muscle.


The influence of vagotomy on superior mesenteric artery blood flow.


The surgical treatment of rectal procidentia.


Experimental production and prevention of injury due to cuffed tracheal tubes.


Pulmonary injury associated with thermal burns.


Postvagotomy-pyloroplasty dumping and diarrhea.


Total surgical correction of transposition of the great arteries in children less than six months of age.


One stage versus two stage pancreatoduodenectomies for periampullary tumors.


A simple technique for intermaxillary fixation.


Radical groin dissection.

Radical groin dissection.


Can these bones live?

Can these bones live?


Medical problems of life assurance.

Medical problems of life assurance.


The diagnosis and surgical management of degenerative arterial disease. Some aspects of the radiology of degenerative disease--a summary.


Presidential address on empiricism and method in medicine.


Cellular structure and function.

Cellular structure and function.


Pulmonary embolism.

Pulmonary embolism. This paper discusses causes, hemodynamics, symptoms, and signs of pulmonary embolism.  Severe cases obstruct at least 60 percent of the pulmonary vascular bed.  Small or moderate cases may be easily overlooked.  Symptoms may be only slight chest pain or dyspnoea, fever, giddiness, or irregular heart beat.  In the author's experience with 35 cases of acute massive pulmonary embolism at the Bromptom Hospital oral contraceptives were considered a predisposing factor in 5 cases (14 percent), pregnancy was a possible cause in 2 (6 percent), a recent  operation in 24 (68 percent).  No other recognized factor was thought to have predisposed more than a single case.  Clinical features included cyanosis, collapse, sever chest pain, dyspnoea, sweating, rapid heart rate, falling blood pressure, and occasional coughing up of blood.  Electrocardiograms sometimes gave helpful information.  Chest x-ray was usually not helpful except to exclude other causes.  Heart catheterization and pulmonary arteriography have been done to assess the extent of the embolism.  Emergency surgical pulmonary embolectomy is recommended for extreme cases.  Fibrinolytic agents such as streptokinase may be adequate for less severe cases who have not had a recent operation of do not suffer from a hemorrhagic disorder.


The coeliac syndrome.

The coeliac syndrome.


Allergy. Pulmonary hypersensitivity reactions to inhaled organic dusts.


Lessons of the Olympics.

Lessons of the Olympics.


Athletes at altitude. Lesions of the 1968 olympics games.


Osteo-arthritis.

Osteo-arthritis.


Osteoarthrosis.

Osteoarthrosis.


Medical aspects of life assurance.

Medical aspects of life assurance.


Retroperitoneal approach for aortic surgery. Experience with 75 consecutive cases.


Acute abdominal aorto-vena caval fistula. Report of 2 cases.


Transection of the thoracic aorta. Recognition and immediate repair.


Operative venography. Its advantages and disadvantages.


Severe bilateral anomalies of the anterior and middle cerebral arteries in subarachnoid hemorrhage.


Radical and esthetic surgery for varicose veins of the legs.


Hypophysectomy; the technic of choice for diabetic retinopathy, pituitary tumors, and metastatic breast cancer.


Familial occurrence of chondrocalcinosis (pseudogout syndrome).


California virus (La Crosse strain) encephalitis.


Sarcoidosis.

Sarcoidosis.


Myocardial ischemia in infants. Its role in three common congenital cardiac anomalies.


Extensive tracheal resection and tracheobronchial reconstruction.


Cardiac operations in patients with left atrial thrombus. Incidence and prevention of postoperative embolism.


An anatomical comparison of human pig, calf, and sheep aortic valves.


Cardiovascular effects of lidocaine.

Cardiovascular effects of lidocaine.


Segmental agenesis of inferior vena cava with azygos substitution. Angiographic findings.


Surgery for acute myocardial infarction.


Complications of ventriculoatrial shunting for hydrocephalus requiring cardiac operation.


Simplified method for creation of a myocardial tunnel.


Before and after residency.

Before and after residency.


Flexible malecot catheter for open-heart surgery.


Brain amine content and functional maturity in the fowl: the effects of pargyline.


The pharmacological properties of ibuprofen, an anti-inflammatory, analgesic and antipyretic agent.


Protein deficiency and tolerated oral doses of endosulfan.


Acute effects of alpha-methyltyrosine on brain catecholamine levels and on spontaneous and amphetamine-stimulated motor activity in mice.


Effect of several new antiarrhythmic agents on atrial contractility.


Kinetics of distribution and metabolism of diazepam and chlordiazepoxide in mice.


Effect of cocaine on norepinephrine-induced lipolysis in anesthetized dogs and in isolated rat and dog fat cells.


Acetylcholine and atropine in ventricular arrhytmias following coronary occlusion in the dog.


Pharmacology of phentermine.

Pharmacology of phentermine.


Bioactivation of 5-oxo-(D-trans-2-phenylcyclopropyl)-L-2-pyrrolidone carboxamide (EX 4883) into a monoamine oxidase inhibitor by a soluble fraction enzyme system.


Differential action of eserine and methamphetamine on the limbic system.


Systemic and coronary hemodynamic effects of 3-(beta-diethylamino-ethyl)-4-methyl-7-carbethoxy-methoxy-2-oxo-(1,2-chromene)-hydrochloride (Intensain, A-27053).


Isotope techniques in evaluation of divalent iron and bone metabolism in renal failure.


Ethnic variability in glucose tolerance and insulin secretion.


Seizures begnning after the age of 60.

Seizures begnning after the age of 60.


A new sign in Behcet's syndrome: scanty fungiform papillae in tongue.


Toxic effects following ingestion of C-4 plastic explosive.


Acetazolamide and sodium bicarbonate induced nephrocalcinosis and nephrolithiasis; relationship to citrate and calcium excretion.


The syndrome of inappropriate antidiuretic hormone secretion; an unusual case.


Discipline: a central issue of our times.


The Budd-Chiari syndrome caused by Aspergillus; two patients with vascular invasion of the hepatic veins.


Cryptococcal granulomata of the skin in a patient with pulmonary and cerebral cryptococcosis.


Erythropoietic protoporphyria: a report of the first South Australian case.


Methotrexate for psoriasis--some impressions seven years later.


The physiology of the cutaneous circulation in man.


Chronic solar dermatosis--an electronmicroscopic study of the epidermis.


Case report: the treatment of xanthomatosis with atromid-S.


A skin test for carcinogens.

A skin test for carcinogens.


Chemoprophylaxis in Babesia argentina infection in cattle.


Studies on the particle-bound carbohydrate sulphoamide sulphohydrolase and carbohydrate sulphate sulphohydrolase of Flavobacterium heparinum.


Observations on the enzymic sulphurylation of tyrosyl derivatives.


Purification and partial characterization of peroxidase from red algae.


The amino acid sequence of penicillinase from Bacillus licheniformis.


Breakdown on pyridine haemichrome by liver extracts.


Coupled oxidation of myoglobin with ascorbate as a model of haem brakdown in vivo.


The relationship between plasma and tissue vitamin E concentrations in man.


Purification of adenosine deaminase from bovine lung and spleen.


The function of the non-specific adenylyl aminohydrolase of Aspergillus oryzae.


The biosynthesis of 3-beta-hydroxyandrosta-5,16-diene and its further metabolism in boar testis.


Phospholipases in cerebrospinal fluid and cell fractions of human brain.


The proteolytic action of arvin on human fibrinogen.


The localization of peptidases in microvilli from the brush border of the proximal renal tubule of the rabbit.


The presence of pancreatic proteases in particulate preparations of rat intestinal mucosa.


A component of human duodenal juice that affects intrinsic factor.


Enzymology and blood coagulation.

Enzymology and blood coagulation.


The assay of alpha-amylase.

The assay of alpha-amylase.


Dissociationof beta-casein from casein micelles and complexes.


Dissociation of casein micelles to soluble casein complexes.


The chemistry of the activation of prothombin.


Goat immunolobulin G. Peptide chains and terminal residues. Goat immunoglobulin G (IgG) was isolated and characterized. The molecular weights of the IgG and its heavy chains and light chains were found to be 144000, 53600 and 23000 respectively. The light chain corresponds to human L type as was shown by the absence of C-terminal S-carboxymethylcysteine and its high content of N-terminal pyrrolid-2-one-5-carboxylic acid (PCA). The major C-terminal residue of the light chain was serine and the major N-terminal dipeptide was PCA-Ala (0.6mole/mole). The major C-terminal residue of the heavy chain was glycine and the N-terminal sequence of the heavy chain is PCA-Val-Gln. This tripeptide was obtained in a 70% yield.


Comparison of the protein-synthesizing machinery in the skeletal muscle of normal and dystrophic Bar Harbor mice. 1. Although the total weight of leg muscle increased with the age of a normal mouse the DNA and RNA content per leg did not change significantly. 2. The weight of leg muscle from a dystrophic mouse was only about 45% of that from a normal mouse but the DNA and RNA contents were the same and hence similar DNA/RNA ratios were obtained. 3. The total ribosome contents of normal and dystrophic mice were the same on a whole-leg basis, and for both the free ribosomes were about 60% of the total. However, comparison with similar data from liver suggested that some loss of ribosomes occurred during the isolation procedure. 4. The polyribosome patterns obtained by density-gradient centrifugation were the same for normal and dystrophic muscle, and comparable polyribosome fractions of different sizes obtained from such gradients had similar capacities for the incorporation of radioactive amino acids in a standard protein-synthesizing system. 5. By using a standard protein-synthesizing system with normal polyribosomes similar extents of incorporation were found with normal- or dystrophic-muscle pH5 fraction or partially purified transfer RNA preparation. 6. It is concluded that there is no absolute difference between the protein-synthesizing systems of normal and dystrophic mouse muscle and that the observed apparent differences result from concentration differences caused by changes in muscle volume. 7. A possible cause of the failure of dystrophic muscle to resynthesize myofibrils is also suggested.


Molecular cohesion in plant cell walls. Methylation analysis of pectic polysaccharides from the cotyledons of white mustard. Methylation analysis was used to characterize the pectic polysaccharides from mustard cotyledons, a tissue with potential for rapid biological change involving the walls. The methylated sugars were identified by g.l.c. and paper chromatography after conversion of uronic acid derivatives into [(3)H]hexoses, and confirmed by the formation of crystalline derivatives of most of the main products, which were: 2,3-di-O-methyl-d-[6-(3)H]galactose, 2-O-methyl-d-[6-(3)H]galactose, 3,4-di-O-methylrhamnose, 3-O-methylrhamnose, 2,3,5-tri-O-methyl-l-arabinose, 2,3-di-O-methyl-l-arabinose, 2-O-methyl-l-arabinose, 2,3,4-tri-O-methyl-d-xylose and 2,3,4,6-tetra-O-methyl-d-galactose in the molar proportions 1.00:1.14:0.54:0.74:2.86:2.50:2.24:1.88:0.32. The structural units present are similar to those in wellknown polysaccharides from mature tissues, but their proportions are strikingly different. Uninterrupted and unbranched galacturonan segments can therefore contribute little cohesion to these walls, and it is suggested that this correlates with a function of the wall matrix to hydrate and permit readjustment, during germination, of structural elements or wall surfaces or both.


Calorimetric studies of the haemoglobin-haptoglobin reaction. Haptoglobin binds haemoglobin so firmly that there is practically no dissociation. It would be expected that the heat of the reaction would be relatively large. The development of the microcalorimeter by Benzinger offered the opportunity to measure the heat of reaction. The experiments were carried out in the Beckman 190B Microcalorimeter in two ways: (1) a constant amount of haptoglobin (Kabi; 65mg.) with different amounts of haemoglobin, and (2) a constant amount of haemoglobin (32.5mg.) with different amounts of haptoglobin. The proteins, each in 5ml. of 0.15m-phosphate buffer, pH7.4, were placed in equal-volume calorimeter cells. The heat produced/mg. of haemoglobin was calculated from the slope of the curve for a constant amount of haptoglobin and from the maximum heat for a constant amount of haemoglobin. This heat is about 70kcal./mole at 37 degrees . DeltaH varies with temperature, being -70.2 at 37 degrees , -29.7 at 20 degrees and 7.2 at 4 degrees . From the amount of haptoglobin required to attain maximum heat with 32.5mg. of haemoglobin and the amount of haemoglobin required to attain maximum heat with 65mg. of haptoglobin, it appears that at excess of haptoglobin there is competition between the reactions of 2moles of haptoglobin with 1mole of haemoglobin (or 2 alphabeta-chains) and 1mole of haptoglobin with 1mole of haemoglobin.


Arginine metabolism in insects. Role of arginase in proline formation during silkmoth development. 1. Ornithine delta-transaminase (l-ornithine-2-oxo acid aminotransferase, EC 2.6.1.13) and Delta(1)-pyrroline-5-carboxylate reductase [l-proline-NAD(P) 5-oxidoreductase, EC 1.5.1.2] were demonstrated in fat-body and flight-muscle tissues of the silkmoth Hyalophora gloveri. Arginase (l-arginine ureohydrolase, EC 3.5.3.1) is also present in these tissues. 2. Arginase, ornithine transaminase and pyrroline-carboxylate reductase are generally considered to make up the catabolic pathway for the conversion of arginine into proline. The conversion of l-[U-(14)C]arginine into [(14)C]proline by intact fat-body tissue was used to show that the enzymes in insect fat body also function in this capacity. 3. Of the three enzymes of the catabolic pathway, only arginase increased during adult development and the increase coincided with the emergence of the winged adult moth. Since proline appears to be a major substrate utilized in insect flight metabolism, the increase in arginase activity at this stage suggests a major role for arginase in proline formation.


Kallikreins.

Kallikreins.


Isolation of a third bovine neurophysin. 1. A third native hormone-binding protein, neurophysin-C, has been isolated from acetone-desiccated bovine pituitary posterior lobes. 2. This protein was detected in lysates of neurosecretory granules isolated from bovine pituitary posterior lobes. 3. The molecular weight appears to be close to 10000. 4. Neurophysin-C is similar in amino acid composition to neurophysin-I and -II; it contains a single residue of tyrosine and of methionine. The N-terminal amino acid in all three neurophysins is alanine. 5. Neurophysin-C accounts for approximately 15% of the total hormone-binding protein present in the pituitary posterior lobes. 6. The new neurophysin forms complexes with oxytocin as well as with [8-arginine]-vasopressin. The complex with vasopressin has been crystallized. 7. Bioassay of the pressor and oxytocic activities of the protein-hormone complexes shows that neurophysin-C binds one molecule of either vasopressin or oxytocin.


The nature of the sex-linked differences in glutathione peroxidase activity and aerobic oxidation of glutathione in male and female rat liver. 1. Glutathione peroxidase activity in the livers of sham-operated female rats was about 60% higher than in similarly treated male rats. The value in the ovariectomized female was about the same as that in the castrated or sham-operated male. 2. Glutathione peroxidase activity changed during the oestrous cycle. The highest value was in oestrus, and was about 50% higher than the lowest activity, which was found in dioestrus. The activity in proestrus and in metoestrus was respectively about 20 and 30% higher than in dioestrus. 3. In the pregnant female 1 or 2 days before term, glutathione peroxidase activity was about 20% higher than that in the female in oestrus. 4. Subcutaneous implants of both oestra-diol and progesterone in the gonadectomized rats increased the glutathione peroxidase activity approximately to the values found in the female at oestrus. 5. The rate of aerobic oxidation of GSH in the female rat liver was about 80% higher than in the male and about 110% higher than in the gonadectomized rats. Treatment of gonadectomized rats with subcutaneous implants of oestradiol and of progesterone increased the rate of oxidation of GSH by about 100%. 6. In the presence of azide the rate of GSH oxidation in the male and in the female was respectively about 3.5- and 2.1-fold that in the absence of azide. In castrated or ovariectomized rats the increase due to the presence of azide was about 2.4-fold. In the gonadectomized rats treated with oestradiol or progesterone the rate of GSH oxidation in the presence of azide was about 2.2-fold that in its absence. 7. The rate of lipid peroxidation in female was 15-30-fold that in male or in gonadectomized rats. Treatment of the gonadectomized rats with oestradiol or with progesterone increased the rate of lipid peroxidation up to values that were even higher than in the female. In the presence of GSH the formation of malonaldehyde from peroxides was virtually eliminated. 8. The results suggest that the sex-linked differences in glutathione peroxidase activity, in the rate of GSH oxidation and in the rate of lipid peroxidation are due to the female sex hormones. 9. It is suggested that both the catalase activity and the rate of hydrogen peroxide formation are higher in the male than in the female. 10. Sex-linked changes in glutathione peroxidase, in the rate of GSH oxidation and in the rate of lipid peroxide formation are discussed in relation to the metabolism of oestrogens in the liver and also to the possible nature of those sex-linked changes.


Two fractions required for cell-free protein synthesis with components from rabbit reticulocytes. An extract was prepared from rabbit reticulocyte ribosomes after treatment with potassium chloride as described by Miller, Hamada, Yang, Cohen & Schweet (1967). This extract has been shown to convert monoribosomes into polyribosomes during protein synthesis in vitro (Cohen, 1968). The nature of this extract was studied in greater detail. Centrifugation of the extract through a sucrose density gradient separated the activity into a fast-sedimenting fraction. The two fractions were shown to have different functions in stimulating cell-free protein synthesis and their active components were shown to be protein or partly protein in nature. Each fraction was analysed by electrophoresis and in the analytical ultracentrifuge. It was concluded that the active component in the fast-sedimenting fraction had a sedimentation coefficient of 15.5s and that of the slow-sedimenting fraction 10.5s.


A sodium ion concentration gradient formed during the absorption of glycine by mouse ascites-tumour cells. 1. To deplete them of ATP the tumour cells were starved at 37 degrees in a Ringer solution containing 33m-equiv. of Na(+)/l., 131m-equiv. of Li(+)/l., 2mM-sodium cyanide and 0.1mm-ouabain. The cellular content of K(+) was largely replaced by Li(+), but cellular [Na(+)] remained near 33m-equiv./l. 2. The addition of 12mm-glycine to the system caused cellular [Na(+)] to increase, during the next 4min., by about 4m-equiv./l., so that it slightly exceeded extracellular [Na(+)]. This occurred in parallel with the absorption of glycine. 3. The cellular K(+) content fell by an amount representing about 10% of the amount of Na(+) absorbed. 4. The results provide a clear demonstration that the flow of glycine into the cells is linked to a parallel movement of Na(+); K(+) appears to play a facultative role in the carrier system, whereas Li(+) is almost inert. 5. The effects produced by glycine were not reproduced by l-arabinose.


The effects of substrates on the optical rotatory dipersion of carnitine acetyltransferase. 1. The optical rotatory dispersion of carnitine acetyltransferase is altered in the presence of l-carnitine or acetyl-l-carnitine. These changes, which include an increase in the reduced mean residue rotation at 233nm. ([M'](233)), suggest that substrate binding causes the enzyme to unfold. 2. CoA and acetyl-CoA have no immediate effect on [M'](233) and CoA has no effect on the change in this parameter induced by l-carnitine. 3. The change in [M'](233) was used as a measure of the degree of saturation of the enzyme with carnitine substrates. Dissociation constants for the enzyme complexes with l-carnitine, d-carnitine and acetyl-l-carnitine were determined in this way. 4. Prolonged incubation of carnitine acetyltransferase in the presence of CoA leads to a small increase in the value of [M'](233) accompanied by irreversible inhibition of the enzyme. 5. Optical-rotatory-dispersion studies of two specifically inhibited enzyme forms are reported.


The relationship between nitrogen fixation and the production of HD from D2 by cell-free extracts of soya-bean nodule bacteroids. 1. Cell-free extracts prepared from soya-bean nodule bacteroids produced HD from D(2) in the presence of dithionite, an ATP-generating system and nitrogen. 2. Crude extracts of bacteroids or of Azotobacter vinelandii showed some background D(2) exchange when any one of these was omitted. 3. Partial purification of bacteroid extracts diminished this background activity and gave increased D(2) exchange and nitrogen fixation. 4. Although increasing pN(2) stimulated both reactions, the apparent K(m) (N(2)) for nitrogen fixation was much higher than the apparent K(m) (N(2)) for D(2) exchange when partially purified bacteroid extracts were used. 5. Carbon monoxide was a competitive inhibitor of nitrogen fixation by partially purified bacteroid extracts, but D(2) exchange was inhibited in a non-competitive fashion. 6. These results are discussed in relation to the possible existence of enzyme-bound intermediates of nitrogen fixation.


Effects of insulin on the pattern of glucose metabolism in the perfused working and Langendorff heart of normal and insulin-deficient rats. 1. The metabolic pattern of [U-(14)C]glucose in the isolated rat heart has been studied, with both retrograde aortic (Langendorff) and atrially (working) perfused preparations in the presence and absence of insulin, in normal animals, animals rendered insulin-deficient (by injection of anti-insulin serum 1hr. before excision of the heart) and animals rendered diabetic by streptozotocin injection 7 days before use. 2. Radioautochromatograms of heart extracts show that the pattern of glucose metabolism in heart muscle is more complex than in diaphragm muscle. In addition to (14)CO(2), glycogen, oligosaccharides, phosphorylated sugars and lactate (the main metabolites formed from [(14)C]glucose in diaphragm muscle), (14)C label from [(14)C]glucose appears in heart muscle in glutamate, glutamine, aspartate and alanine, and in tricarboxylic acid-cycle intermediates. 3. By a quantitative scanning technique of two-dimensional chromatograms it was found that a mechanical work load stimulates glucose metabolism, increasing by a factor of 2-3 incorporation of (14)C into all the metabolites mentioned above except lactate and phosphorylated sugars, into which (14)C incorporation is in fact diminished; (14)CO(2) production is equally stimulated. 4. Addition of insulin to the perfusion fluid of the working heart causes increases in (14)C incorporation, by a factor of about 1.5 into (14)CO(2), by a factor of about 3-5 into glycogen, lactate and phosphorylated sugars, by a factor of about 2-3 into glutamate and tricarboxylic acid-cycle intermediates and by a factor of about 0.5 into aspartate, whereas incorporation into alanine and glutamine is not affected. The effect of a work load on the pattern of glucose metabolism is thus different from that of insulin. 5. Increasing the concentration of glucose in the perfusion fluid from 1 to 20mm leads to changes of the pattern of glucose metabolism different from that brought about by insulin. (14)CO(2) production steadily increases whereas [(14)C]lactate and glycogen production levels off at 10mm-glucose, at values well below those reached in the presence of insulin. 6. In Langendorff hearts of animals rendered insulin-deficient by anti-insulin serum or streptozotocin, glucose uptake, formation of (14)CO(2) and [(14)C]lactate, and (14)C incorporation into glycogen and oligosaccharides are decreased. In insulin-deficient working hearts, however, glucose uptake and (14)CO(2) production are normal, whereas incorporation of (14)C into glycogen and [(14)C]lactate production are greatly decreased. 7. Insulin added to the perfusion fluid restores (14)C incorporation from glucose into (14)CO(2), glycogen and lactate in the Langendorff heart from animals rendered insulin-deficient by anti-insulin serum; in hearts from streptozotocin-diabetic animals addition of insulin restores (14)C incorporation into glycogen and lactate, but (14)CO(2) production remains about 50% below normal. 8. The bearing of these results on the problem of the mode of action of insulin is discussed.


Quantitative determination of deoxyribonucleic acid in rat brain. 1. A procedure is given for spectrophotometric analysis of rat brain DNA after its resolution into component bases. Amounts of tissue in the range 50-100mg. can be used. 2. The amount of DNA obtained by the present method is 80% greater than that reported for rat brain by a previous procedure specific for DNA thymine. Identity of the material is established by the base ratios of purines and pyrimidines. The features responsible for the higher yield are the presence of dioxan during alkaline hydrolysis of tissue, the determination of the optimum concentration of potassium hydroxide in this step and omission of organic washes of the initial acid-precipitated residues. 3. The requirement for dioxan during alkaline hydrolysis suggests a possible association of brain DNA with lipid. The concentration of potassium hydroxide that gives maximum yield is 0.1m, indicating that there may be internucleotide linkages in this DNA that are more sensitive to alkali than those of liver or thymus DNA. 4. This procedure gives low yields of DNA from liver. It is not suitable for analysis of the DNA from this tissue.


Acetoacetylation of insulin.

Acetoacetylation of insulin. Insulin was treated with diketen at pH6.9. The reaction mixture was resolved into four components by DEAE-Sephadex chromatography. The first component was unchanged insulin. The second and third components were shown by end-group analysis to be substituted on phenylalanine B-1 and glycine A-1 respectively. The fourth component was disubstituted on both phenylalanine B-1 and glycine A-1. The in-amino group of lysine B-29 was not involved in the reaction at low reagent concentrations. The purity of these derivatives was checked by their electrophoretic behaviour and by measurement of the rate of their reaction with trinitrobenzenesulphonic acid. The hormonal activity of the derivatives was determined. The effect of the modifications on the hormonal activity and the tertiary structure of insulin is discussed.


Chemistry of the active site of rhodopsin.


Utilization of L-threnonine by a pseudomonad: a catabolic role for L-threonine aldolase.


The reaction catalysed by a partially prufied nucleoside triphosphate-dependent deoxyribonucleic acid-breakdown system from Mycobacterium smegmatis.


Studies on the metabolism of steroids in the foetus. Biosynthesis of 6-alpha-hydroxytestosterone in the human foetal liver. After incubation of testosterone with 105000g microsomes of human foetal liver, 6alpha-hydroxytestosterone was isolated and identified by t.l.c. and g.l.c.-mass spectrometry. This is the first example of 6alpha-hydroxylation of C(19) steroids in the human liver, and the finding is discussed in relation to earlier reports of 6-oxygenated C(19) and C(18) steroids in pregnant women.


The oxidation of acetate, ethanol and pyruvate by baker's yeast.


Glycopeptide linkages in a phosphomannan peptide from yeast cell walls.


II. The teaching of community medicine in the undergraduate curriculum.


MD by thesis from general practice.

MD by thesis from general practice.


A method for guiding professional socialization in medical education.


An introductory course: medicine as science and service.


An orientation coruse for first-year medical students.


An experiment in beer-tasting.

An experiment in beer-tasting.


The place of microbiology teaching in the medical curriculum.


Graduates of British and Irish medical schools taking state board examinations in America.


The use of cluster analysis to group examination candidates.


On the evaluation of examination results by computer.


Confidence testing: an extension of multiple-choice testing.


A multiple-choice examination in physiology.


Extracorporeal perfusion of human cadaver kidneys from autopsy cases.


Electroencephalographic findings in anesthesia for open heart surgery.


A statistical study on the diagnosis of lumbar intervertebral disc herniation.


Clinical and endoscopic studies on xanthomatosis of the stomach.


Criteria for differentiation of brown and white fat in the rat.


Effects of dopamine on the liver before and following administration of endotoxin.


Biosynthesis of natural products. IV. Biosynthesis of itaconitin. 1. Degradation studies on itaconitin.


Biological activities of drugs. VII. Structure-activity relationship of sulfonamide carbonic anhydrase inhibitors.


Selenium distribution and radiotocopherol metabolism in the pregnant ewe and fetal lamb.


Biosynthesis of natural products. VI. Biosynthesis of usnic acid in lichens. A general scheme of biosynthesis of usnic acid.


An anti-inflammatory proteinase, kinonase BI obtained from Streptomyces kinoluteus.


Biosynthesis of natural products. VII. Biosynthesis of usnic acid lichens. Seasonal variation observed in usnic acid biosynthesis.


Modified lipophilic vitamin. 3. Distribution and excretion of tocopheronolactone.


Pharmacokinetic analysis on the disappearance of ethoxybenzamide from plasma. Statistical treatment of data of two compartmental model by a digital computer.


Synthesis of antibacterial agents having both sulfanilamido-and nitrofuryl- groups in the molecules. I.


Complications in using rabbits for the study of oral drug absorption.


The total amino acid sequence of substance A produced by Streptomyces carzinostaticus.


Concentration of insect hemolymph proteins under various experimental conditions.


Glutamine synthetase activity in tissues of lower vertebrates.


Carbohydrate metabolism in groud squirrels during the summer season.


Loss of rhythmic activity in female ants caused by mating.


The economics of temperature regulation in neotropical bats.


DDT-dehydrochlorinase. I. Purification and characterization.


The green pigment of Patella (mollusca) ova.


Lactate dehydrogenase activity and anaerobic metabolism during embryonic development in Artemia salina.


A comparative study of spike potentials in response to nerve stimulation in the vas deferens of the mouse, rat and guinea-pig.


Electrolyte metabolism in the hibernatg hedgehog (Erinaceus europaeus).


Evidence for direct excretion of blood ammonia by an ammoniotelic amphibian.


A comparative study of the temporal patterns of cutaneous water vapour loss from some domesticated mammals with epitrichial sweat glands.


Determination of bristle direction in Drosophila.


The role of thyroxine in the formation of gland rudiments in the skin of Xenopus laevis.


Efficiency of translation of messenger-RNA before and after fertilization in sea urchins.


The intracellular location of glutamate dehydrogenase in chick embryo liver during development.


Food contaminants and gastrointestinal or liver neoplasia. Survey of experimental observations.


Comparison of chlorinated hydrocarbon pesticides in maternal blood and placental tissues.


Responses of Chlamydomonas reinhardtii to peroxyacetyl nitrate.


The lead uptake by perennial ryegrass and radishes from air, water and soil.


Cough and peak flow rates of municipal employees in Rotterdam.


A survey of respiratory disease among New York City postal and transit workers. 2. Ventilatory function test results.


The silent period and control of isometric contraction of the triceps surae muscle.


Ribonucleotide reductase rom regenerating rat liver.


Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney.


Relative proportions of mitochondrial and nuclear DNA in yeast under various conditions of growth.


Concerning the specific features of muscular electrogenesis in central disturbances of the tone and in hyperkinesias.


Cyanogen bromide peptides from the alpha 1-chain of cod skin collagen.


The influence of ribosomal factors during the maturation of reticulocytes.


Oxidative phosphorylation and compartmentation of fatty acid metabolism in brown fat mitochondria.


Formation and structure of gels and fibrils from glucagon.


Role of RNA polymerase stimulating factor on chain initiation.


Heterogeneity of erythrocyte catalase. Correlations between sulfhydryl group content, chromatographic and electrophoretic properties.


Yeast alcohol dehydrogenase: SH groups, disulfide groups, quaternary structure, and reactivation by reductive cleavage of disulfide groups.


Short-term effects of calcium, potassium, and of ouabain on metabolite levels in the frog heart in vivo.


18-O-studies with citrate synthase and malate synthase.


The effect of senility on skeletal muscles in the mouse.


Life span data for the small fish, Oryzias latipes.


Respiration in Drosophila. 3. Influence of preimaginal environment on respiration and aging in Drosophila melanogaster hybrids.


The miscible pool and turnover rate of cortisol in the aged, and variations in relation to time of day.


Life span, chronologic disease patterns, and age-related changes in relative spleen weights for the mongolian gerbil (Meriones unguiculatus).


Absence of a life-shortening effect of amino-acid analogues on adult Drosophila.


Determination of -SH and -SS- groups in proteins. II. The age-dependence of -SH and -SS- contents in the soluble protein fractions of the eye lens.


The effect of fluctuating environmental temperatures on the length of life of adult Drosophila.


Effect of environmental temperature and undernutrition on collagen aging.


Tissue respiration and glycolysis in quadriceps femoris and heart of rats of different ages during hypodynamia.


Determination of -SH and -SS- groups in proteins. 3. Age-related changes observed with the insoluble (albuminoid) protein fraction of the eye lens.


Aspects of ageing in the guppy, Lebistes reticulatus (Peters). IV. The ovary.


Invertebrates and their diseases as models for the study of disease processes in man.


Human chromosome aberrations induced by radiation, chemicals and viruses. Radiation-induced chromosome aberrations in man: a possible biological dosimeter.


The problems faced by geriatricians.

The problems faced by geriatricians.


Diagnosis and treatment of acute mesenteric vascular insufficiency.


Control of biochemical precursors of coronary heart disease.


Transformation and recovery of the crown gall tumor cell: an experimental model.


Allergic headache.

Allergic headache.


Differential diagnosis of headache: temporomandibular joint dysfunction.


Vasomotor function in migraine.

Vasomotor function in migraine.


Living models for the study of disease processes in man. Discovery and exploitation of animalmodel diseases.


The milieu interieur of bone: Claude Bernard revisited.


Further observations on surgery of the nervus intermedius.


Emotional aspects of chronic tension headache: a study of soldiers and their dependents.


Egg shell formation and bone resorption in laying hens.


Biochemical events in the animal cell cycle.


Viral defectiveness. Introductory remarks.


Loss of body weight in relation to rise in body temperature in goats.


Influenza virus: structure, replication and defectiveness.


Synthesis of an enzyme determined by an erythrocyte nucleus in a hybrid cell.


The choline and serum protein requirements of mouse fibroblast cells (strain LS) in culture.


Synthesis of cortical proteins in Tetrahymena.


On the surface coat and flagellar adhesion in trypanosomes.


Ultrastructural observations on deep-etched thylakoids.


The crystal lattice of the pyrenoid matrix of Prorocentrum micans.


Evidence for a polarized movement of the lateral loops of newt lampbrush chromosomes during oogenesis.


Formation and loss of DNA in intestinal epithelium.


Cytoplasmic DNA-containing bodies and the response of amoebae to dimidium bromide.


On the metabolism of 16-alpha-hydroxy-C21-steroids. II. Evidence for the presence of a glucuronide of 16-alpha-hydroxypregnenolone in human urine and its utility in estimating the rates of production of 16-alpha-hydroxyprogesterone and 16-alpha-hydroxypregnenolone.


On the metabolism of 16-alpha-hydroxy-C21-steroids. 3. Evidence for high rates of production of 16-alpha-hydroxyprogesterone and 16-alpha-hydroxypregnenolone in the salt-losing form of congenital adrenal hyperplasia.


Effects of sodium loading, sodium depletion and posture on plasma aldosterone concentration and renin activity in hypertensive patients.


Magnesium depletion during prolonged fasting of obese males.


Testosterone and androstenedione metabolism in the polycystic ovary syndrome: studies of the percentage binding of testosterone in plasma.


Growth hormone in hypersecretory diseases of the adrenal gland.


Diabetogenic effect of L-asparaginase.

Diabetogenic effect of L-asparaginase.


Identification of preganglionic parasympathetic neruons in the sacral spinal cord of the cat.


Development of a membrane oxygenator: overcoming blood diffusiolimitation.


The effects of environmental complexity on the histology of the rat hippocampus.


Water and solute excretion following cardiopulmonary bypass with hemodilution. The effects of the osmolarity of the perfusion prime.


Spinal cord representation of the micturition reflex.


Closed-chest left heart bypass without anticoalation.


An appraisal of blood trauma and the blood-material interface following prolonged assisted circulation.


Oxygen consumption after oxygen therapy fo hypoxemia.


Mitral and aortic valve replacement with fascia lata on a frame.


A new technique for replacement of the mitral valve by a semilur valve homograft.


Hemynamic state after open mitral valve replaceent and reconstruction.


Aneurysms of aortic arch. Simplified technique for excision and prosthetic replacement.


A predictive study of adjustment to cardiac surgery.


Mechanical stirrer for the rapid and efficient mixing of reaction mixtures in cuvettes.


Shielded flame emission burner assembly for use with atomic absorption spectrophotometers.


An improved gradient maker using a peristaltic pump for the simultaneous preparation of six linear sucrose gradients.


An electrophoresis power supply.

An electrophoresis power supply.


Studies on the mechanism of 7,12-dimethylbenz[a] anthracene leukemogenesis in mice. II. The role of thymus in DMBA leukemogenesis.


Studies on the mechanism of 7,12-dimethylbenz[a] anthracene leukemogenesis in mice. 3. Acceleration of DMBA leukemogenesis in mice by pretreatment of cortisone acetate.


On the response patterns of spinal neurons elicited by stimulating the ventro-lateral nucleus of the thalamus.


Studies on the lipids of neoplastic tissues. II. Lipid contents and fatty acid compositions of the lipids of several organs of tumor (NF sarcoma) bearing mice.


Studies on the chronic gastritis. I. A clinicopathological study.


Studies on the mechanism of 7,12-dimethylbenz[a] anthracene leukemogenesis in mice. I. Strain difference in susceptibility of DMBA leukemogenesis.


AMA, Rep. Hall submit health insurance plans to House Ways and Means Committee.


The physician's obligation to the development of managerial skills in health care facilities.


Tumor growth rate and its clinical applications.


Median rhomboid glossitis. Case report.

Median rhomboid glossitis. Case report.


A coding technique for detecting 30 diseases of the skin. A study.


Intravenously-administered methotrexate and radiotherapy in the treatment of advanced lesions of the oral cavity and the pharynx.


These are claims for hospital corporations: capital, talent, size, centralization.


Big determination to stay put helps hospital cope with small site.


How to make competition fair: have the same rules for all hospitals.


Survey shows hospital pharmacist in advisory role.


Scheduling, design and procedures are bases for setting O.R. policy.


300 beds is minimum size for the urban hospital.


Employes should know what central service is and where it fits.


Pharmacist could help nurse more if the law let him.


You can't do today's nursing with yesterday's attitudes.


Homelike meal atmosphere aids psychiatric patients.


How to convert used developing fluid into usable money.


Public relations. Cashier's window is good place to explain costs.


Modern hospital purchasing. Here are nine steps to take in purchasing for a new facility.


Court declares California abortion law invalid, reverses doctor's conviction.


Hospital makes movie to train housekeeping staff.


Threat, challenge, opportunity or fizzle?


Hospitals haven't taken the part they should in regional programs.


Hemodialysis in the home.

Hemodialysis in the home.


The academic condition in the United States.


Experimental invalidation of the principle of competitive exclusion.


Sequence of the first 175 nucleotides from the 5' terminus of Qbeta RNA synthesized in vitro.


Inter-hemispheric transfer of fresh debris from French nuclear tests in 1968.


Sedimentation properties of RNA species homologous to mitochondrial DNA in HeLa cells.


Helicoidal structure of paramyosin.

Helicoidal structure of paramyosin.


Circular dichroism of long wavelength forms of chlorophyll alpha.


Carotenoid bilayer lipid membrane model for the visual receptor.


Capacitation of hamster spermatozoa by bovine follicular fluid.


New mechanism for calcification of skeletal tissues.


Experimental model for studying the effect of electric current on bone in vivo.


Effect of alginate on the absorption and excretion of 203Pb in rats fed milk and normal diets.


Effect of alginate on the absorption of lead in man.


Direct recording of K and Na current-potential characteristics of squid axon membrane.


Rheological simulation of synovial fluid by a synthetic polymer solution.


Non-injurious ultrasonic technique for observing flow in the human aorta.


Localization of variable antigens in the surface coat of Trypanosoma brucei using ferritin conjugated antibody.


Transmission of cytoplasmic determinants in amoebae by micro-injection of RNA-containing fractions.


Perinatal structural sex differentiation of the hypothalmus in rats.


Stereometric structure of the hypothalamo-neurohypophysial complex in some Indian catfishes.


The hypothalamic time sequence controlling gonadotrophin release in the immature female rat.


Effect of hypothalamic lesions on the time course of corticosterone secretion.


Studies on the hypothalamic control of TSH secretion.


Turnover of hypothalamic catecholamines during various states of gonadotrophin secretion.


Effect of estrogen on pituitary melanocyte-stimulating-hormone content.


Effect of local injection of 5-hydroxytryptamine into rhinencephalic and mesencephalic structures on pituitary-adrenal function in guinea-pigs.


The influence of altered lighting schedules on PMS-induced ovulation in the Purdue-Wistar rat.


Dietary control in animal experiments.

Dietary control in animal experiments.


Gastrointestinal disorders in Vietnam returnees.


Unusual features of brain stem tumors.

Unusual features of brain stem tumors.


Telecast of a cholecystectomy.

Telecast of a cholecystectomy.


Psychopharmacologic agents in the prevention of psychiatric disorders.


The management of breech presentation.

The management of breech presentation.


Phenylketonuria 1969.

Phenylketonuria 1969.


Arthritis in the aged. Medical aspects.

Arthritis in the aged. Medical aspects.


Terminating pregnancy after first-trimester rubella.


Lower motor neuron disease.

Lower motor neuron disease.


Gynecomastia and tumor.

Gynecomastia and tumor.


How I treat sebaceous cysts.

How I treat sebaceous cysts.


On-the-job nutrition teaching in the hospital.


Clinical application of space technology.


Headaches--psychogenic or organic?

Headaches--psychogenic or organic?


Arthrogryposis multiplex congenita. Susceptibility to injury.


Sexual behavior of adolescents.

Sexual behavior of adolescents.


The place of percutaneous cholangiography in managing the jaundiced patient.


Advances in dentistry.

Advances in dentistry.


Hazards of general practice. A running commentary.


Modern views on physiology. X. The movements of the alimentary tract.


Nicotine injections as the conditioned stimulus in discrimination learning.


Increased alcohol preference in rats following repeated exposures to alcohol.


Effects of LSD on the spontaneous and evoked activity of retinal and geniculate ganglion cells.


Flurothyl toxicity: a remarkable species difference between chick and mouse.


The effect of nicotine on two different types of learning.


Treatment by colour.

Treatment by colour.


The treatment of homosexuality.

The treatment of homosexuality.


Thymic alymphoplasia: a case report.

Thymic alymphoplasia: a case report.


Principles ofsychic function.

Principles ofsychic function.


Diagnostic selective coronary arteriography.


Histochemical study of cells with foamy cytoplasm in the human ovaries at term.


Upper femoral osteotomy in the treatment of paralytic subluxation of the hip due to poliomyelitis.


Plasma renin concentrations in cases with renovascular hypertension.


Banding of the pulmonary artery.

Banding of the pulmonary artery.


To the Editor. Margarine.

To the Editor. Margarine.


Amyloid disease--an unusual cause of megalo-oesophagus.


To the Editor: Fenfluramine (Poderax) for obesity.


To the Editor. Adverse effects from drugs.


The vascular architecture of the different forms of small intestinal villi in the rat (Rattus norvegicus).


Steroid metabolism by the canine intestine. I. Qualitative experiments with progesterone.


Identity of the basally located parietal and enterochromaffin-like cells of the rat gastric mucosa.


Response of Heidenhain pouch to histamine, gastrin and feeding before and after truncal vagotomy in dogs.


Early colectomy in severe ulcerative colitis.


Diagnostic value of the augmented histamine test in cancer of the upper part of the stomach.


Gastric biopsy in peptic ulcer: a follow-up study.


Parietal cell and intrinsic factor antibodies in a Finnish rural population sample.


The stimulation of lactase by feeding lactose.


Cobalt salts: effects in cyanide and sulfide poisoning and on methemoglobinemia.


The effect of the size of the dose on the distribution and excretion of mercury in rats after single intravenous injection of various mercury compounds.


The absorption and distribution of mercury in rats fed organs from rats injected with various mercury compounds.


Utilization of newborn mice in the bioassay of chemical carcinogens.


Effects on man of daily ingestion of small doses of isopropyl alcohol.


The effect of pesticide administration on serum and tissue esterases of rats fed diets of varying casein, calcium, and magnesium content.


The distribution of 2,4-dinitrophenol relative to its cataractogenic activity in ducklings and rabbits.


The metabolism of sodium amylopectin sulfate in the rat.


Toxicity studies with ethyl maltol.

Toxicity studies with ethyl maltol.


Detection, assay and rate of excretion of mecloqualone in animals and man.


Chronic toxicity of dicyclopentadienyliron (ferrocene) in dogs.


The effect of tar on infection.

The effect of tar on infection.


International recommendation for nomenclature of quantities and units in clinical chemistry.


A comparison of x-ray diffraction and infrared technics for identifying kidney stones.


The effect of medication on laboratory test results.


Low plasminogen levels and liver disease.


Preservation of blood in acid-citrate-dextrose anticoagulant solution for more than twenty-one days. Comparison of four solutions.


Evaluation of the Coulter Counter Model S.


Phenacetin antibody cross-reactive with autoimmune erythrocyte antibody.


A rapid screening slide test for hemoglobin S.


Hereditary amyloidosis, the flexor retinaculum, and the carpal tunnel syndrome.


The histology of gonadotropin-secreting bronchogenic carcinoma.


Gliomyosarcoma of the cerebrum. Report of a unique case.


Tears in Valhalla--the National Institutes of Health.


Psychologic aspects of international negotiations.


Revolution, vintage 1968--a psychosocial view.


Poverty, race, and violence.

Poverty, race, and violence.


International and cultural conflicts affecting mental health. Violence, suicide and withdrawal.


The irrational in economic behavior.

The irrational in economic behavior.


Psychopolitical perspectives on federal-state relationships. Mental health participation in the White House-Governor's Conferences of 1967-1968.


Automation: the second emancipation proclamation.


An acoustic mirror in psychotherapy. The audiotape recorder as a psychotherapeutic tool.


The working alliance: description and theory.


Isoniazid prophylaxis in Alaskan Boarding schools. A comparison of two doses.


On-line computerized spirometry in 738 normal adults.


Patterns of lung dysfunction in chronic beryllium disease.


The oxidative enzyme pattern of the urethane-induced pulmonary adenoma.


Pulmonary changes following ischemia of the lower extremities and their treatment.


Tuberculosis studies in Muscogee County, Georgia. VII. A twenty-year evaluation of BCG vaccination in a school population.


Arterial-alveolar difference for carbon dioxide tension by a rebreathing technique.


Effect of intravenous sodium bicarbonate on ventilation, gas exchange, and acid-base balance in patients with chronic pulmonary insufficiency.


Causes of death in patients with bronchiectasis.


On beyond mental health centers. A planning model for psychiatric care.


Death following massive ingestion of isoniazid.


Rabbit erythrocyte hemagglutinins in schizophrenia.


Changes in IQ of schizophrenic children during residential treatment.


Dreaming as metaphor in motion.

Dreaming as metaphor in motion.


Pair comparisons of musical excerpts. Preference bias of schizophrenics and normals.


Organicity measures following repeated LSD ingestion.


Child-adolescent unit in a psychiatric hospital. Five years later.


Serum-enzyme changes in newly admitted psychiatric patients. I.


Phentolamine-induced hyperglycaemia in the rabbit.


The pharmacological actions of an experimental acaricide, NC 5016 (5,6-dichloro-1-phenoxycarbonyl-2-trifluoromethyl benzimidazole).


Time factor in the anesthetic effect of diethyl-ether.


Further studies on the neuromuscular effects of beta-diethylaminoethyl-diphenyl propylacetate hydrochloride (SKF-525-A).


10-N substituted phenothiazine derivatives in auricular arrhythmias.


The effect of fenfluramine and methamphetamine on free fatty acid release in epididymal fat cells of the rat.


Bronchopulmonary and gastrointestinal effects of lobeline.


Inhibition by salicylates of various calcifying connective tissue reactions.


Teratogenicity of marihuana extract as influenced by plant origin and seasonal variation.


Development of increased sensitivity to acetylcholine by the decentralized cochlea.


Spironolactone: reversal of Na retention in the bilateral adrenal enucleated rat.


Cardiovascular changes during tetany and following administration of calcium gluconate in dogs.


Influence of female sex hormones on pentobarbitone sodium anaesthesia in rats.


Metabolism of cyclophosphamide-C14 by various marine species.


Effect of sodium glycolate and sodium ferulate on renal functions in dog.


The phospholipid-dependence of UDP-glucuronyltransferase.


An intermediate in the pH-induced dissociation of glutamate dehydrogenase.


Thiolysis of S-dinitrophenylated creatine kinase with restoration of enzymatic activity.


Demonstration of subunits in beef brain acidic protein (S-100).


Diamide, a new reagent for the intracellular oxidation of glutathione to the disulfide.


The disulfide bond in carboxypeptidase A: a chloride ion NMR study.


Vitamin B12 dependent methylmalonicaciduria: defective B12 metabolism in cultured fibroblasts.


Effects of halogen substituents on base stacking in nucleic acid components: the crystal structure of 8-bromoguanosine.


Agrobacterium tumefaciens RNA in non-tumorous tomato cells.


The physicochemical basis of the functioning of biological membranes: dynamic conformational properties of enniatin B and its K+ complex in solution.


Subfractionation of rat liver microsomes: effects of phenobarbital and 3-methyl cholanthrene.


Subcellular site of glycoprotein synthesis in liver.


Separation of the nitrogenase system of azotobacter into three components and purification of one of the components.


Polyoxin D, a competitive inhibitor of UDP-N-acetylglucosamine: chitin N-acetylglucosaminyltransferase in Neurospora crassa.


The measurement of ventilation.

The measurement of ventilation.


Electrodes for the measurement of oxygen and carbon dioxide tensions.


The quantitative assessment of premedication.


Differential lung ventilation.

Differential lung ventilation.


Influence of anaesthesia on the regional distribution of perfusion and ventilation in the lung.


A method for the continuous display of oxygen uptake and carbon dioxide output.


The impedance cardiograph: development and applications.


A comparison of the effects of halothane and methoxyflurane on the isolated perfused canine liver.


A simple method for the evaluation of O2-CO2 relationships in the gaseous phase.


Peritoneal transfer of carbon dioxide.

Peritoneal transfer of carbon dioxide.


The effect of propranolol on the onset of breathing at birth.


A preliminary evaluation of analogue scoring in sedation.


Impedance pneumograph.

Impedance pneumograph.


Biochemical derangements associated with hypoxia, and their measurement.


Jaundice after anaesthesia.

Jaundice after anaesthesia.


The anal character: a cross-cultural study in Ghana.


Cognitive complexity and sociality.

Cognitive complexity and sociality.


Trait assessment intercorrelation and occupational stereotypy.


Repression-sensitization and Maudsley personality inventory scores: response sets and stress effects.


A clinical validation of the Stott test of motor impairment.


Ego-defence pattern, extraversion-introversion, and sex-role adjustment.


Some data concerning readmission of discharged schizophrenic patients.


A clinically orientated strategy in individual-centred research.


Effects of x-radiation on thymidine incorporation and deoxyribonucleoprotein integrity in rat tissues.


Temperature perturbation of aqueous buffered oxaloacetate solutions.


Plasma peroxidase activity in avian erythroblastosis.


The metabolism of d less than 1.063 lipoprotein in the rat.


Agents affecting lipid metabolism. XXXVII. Separation of rat serum lipoproteins with dextran sulfate.


Effect of yohimbine on 14CO2 production from 14C-pyrrole-ring-labeled DL-tryptophan in rats treated with L-tryptophan, DL-alpha-methyltryptophan, and cortisol.


Extracellular polysaccharides from suspension-cultured sycamore cells.


Decreased monoamine oxidase activity in liver of iron-deficient rats.


Orbital rhabdomyosarcoma in pregnancy.

Orbital rhabdomyosarcoma in pregnancy.


Quinone epoxides. V. The biosynthesis of terreic acid.


Breast cancer and interstitial-cell tumor in a patient with Klinefelter's syndrome.


Metastatic carcinoma simulating agnogenic myeloid metaplasia and myelofibrosis.


Gliomatous teratoma of the tongue. Report of a case.


Hypertrichosis lanuginosa as a sign of internal malignancy.


Cancer of the breast: size of neoplasm and prognosis.


Sialadenoma papilliferum. A previously unreported salivary gland tumor.


Lobular carcinoma in situ. Long term follow-up.


Multicentric well-differentiated liposarcomas. A case report and a brief review of the literature.


Classification of patients with disseminated cancer of the breast.


A cellular and malignant blue nevus: a light and electron microscopic study.


A sequence of virus-like particle formation in the ergastoplasm of Greene's malignant melanoma cells.


Bronchial artery infusion therapy for lung cancer.


Qualitative study of unstable behavior of cancerous cells.


Ultrastructure of a metastatic granulosa-theca cell tumor.


Therapeutic response of intracranial Hodgkin's disease documented by brain scanning.


Primary adenosquamous carcinoma of the stomach. A case report and review.


Interdisciplinary approach to the control of cancer of the breast.


The magnitude of the breast cancer problem in the U.S.A.


Interpretation of the vital statistics of breast cancer.


Efficacy of current treatment methods in cancer of the breast.


Current status of clinical classification of breast cancer.


Professional and hospital programs for the control of breast cancer.


Federal health programs contributing to the control of breast cancer.


Possible hazards in estrogen administration.


The problem of possible effects of oral contraceptives on cancer of the breast.


Detection and diagnosis of carcinoma of the breast.


Endocrinology and epidemiology of breast cancer.


Adequacies and inadequacies of breast examinations by physicians.


Roles of mammography in the early detection of breast cancer.


Detection of breast cancer in a specialized cancer detection center.


Survey mammography as a case finding method for routine and postmastedtomized patients. A 5-year study.


New developments in breast thermography. High spatial resolution.


An evaluation of thermography in the detection of breast cancer. A cooperative pilot study.


Modalities in breast cancer detection: xeroradiography, mammography, thermography, and mammometry.


A surgeon's view of the spread of breast cancer.


Identification of women at high risk for breast cancer.


Biological determinants in patients with breast cancer.


Biopsy--indications and technique.

Biopsy--indications and technique.


Possible role of uninvolved regional nodes in preventing metastasis from breast cancer.


Evaluation of nipple discharge in benign and malignant diseases.


Castration in the treatment of operable breast cancer.


Breast cancer--preoperative and postoperative radiation therapy.


Postoperative care and rehabilitation in breast cancer surgery.


The enigma of breast cancer.

The enigma of breast cancer.


Surgery for categorically incurable cancer of the breast.


Role of radiation therapy in the management of skin metastasis and bone pain in patients with carcinoma of the breast.


Evaluation of adrenalectomy and hypophysectomy in the treatment of metastatic cancer of the breast.


Hormone therapy in inoperable breast cancer.


Status of bone scanning for bone metastases in breast cancer.


Surgical or irradiation castration for patients with advanced breast cancer.


Cellular response to selection for rapid growth in mice.


Studies on larval ecology in relation to the initiation of meiosis in Drosophila melanogaster.


The inheritance of growth and form in the mouse. I. A diallel analysis of weight from birth through ten weeks.


The effect of AC field frequency on the regeneration axis of Dugesia tigrina.


The changing market-place in health services.


Community podiatry--one year after.

Community podiatry--one year after.


Where is Medicaid going?

Where is Medicaid going?


Podiatry's future through the Medicaid crystal ball.


Publicly funded podiatry--first data from office audits of New York City Medicaid practice.


Cavernous hemangioma. A case report.

Cavernous hemangioma. A case report.


Medicaid and community podiatry.

Medicaid and community podiatry.


A classification of tumors incident to the foot and ankle.


Professional fees.

Professional fees.


Acid protease in Nepenthes. II. Study on the specificity of nepenthesin.


Enzymatic hydrolysis of the glycopeptide obtained from Taka-amylase A.


Effect of diazonium-1H-tetrazole and tetranitromethane on trypsin activity.


Biosynthesis of gramicidin S; ornithine activating enzyme.


Studies on denitrification. X. The "denitrifying enzyme" as a nitrite reductase and the electron donating system for denitrification.


Metabolic pattern of phospholipids during germination of mung bean, Phaseolus radiatus var. typicus. I. The incorporation of 32P-orthophosphate into phos- pholipids.


Alginate lyases of pseudomonads.

Alginate lyases of pseudomonads.


The binding of N-acetylglucosamine to lysozyme. Studies on circular dichroism.


Enzymatic studies on the oxidation of sugar and sugar alcohol. 8. Particle-bound L-sorbose dehydrogenase from Gluconobacter suboxydans.


Studies on fin whale pancreatic proteases. II. Purification of the pancreatic proteases.


Further purification and properties of adenosine triphosphate-dependent phenylalanine racemase of Bacillus brevis Nagano.


Studies on substrate induction of serine dehydratase of rat liver.


Stimulation of respiration and lipolysis in rat brown adipose tissue by excess potassium.


Photooxidation of ribonuclease from Aspergillus saitoi.


Facial injury: orbital and periorbital trauma.


Testis, tumor and torsion. Torsion of intra-abdominal testis with tumor.


Opiate addiction.

Opiate addiction.


Aids to cardiac diagnosis from examination of the cervical veins.


The President's message. Doctor shortage.


Where will it end?

Where will it end?


Endothelialisation of experimentally produced mural thrombi in the pig aorta.


Incorporation of radioiodinated serum albumin and low-density lipoprotein into human thrombi in vivo.


The use of scanning electron microscopy in the study of the intestinal villi.


Antigens of Yoshida tumour cells.

Antigens of Yoshida tumour cells.


The histogenesis of pigmented neurofibromas.


Primary intra-alveolar epidermoid carcinoma of the jaw.


Modification of the host response in experimental histoplasmosis.


Fine structure of metaplastic cornified squamous epithelium in the urinary bladder of rats.


The juxtaglomerular apparatus in hypertensive patients with coarctation of the aorta of adult type.


Qualitative and quantitative osteoblastic activity in chronic porcine hypervitaminosis A.


The structural changes in the kidney and urinary tract caused by ethyleneimine ("vinylamine").


Superficial intra-uterine spread of intra-epithelial cervical carcinoma.


Enzyme histochemistry of epithelioid cells in sarcoidosis and sarcoid-like granulomas.


Ultrastructural morphology of the acute inflammatory reaction induced by lymph-node permeability factor (LNPF).


Total absence of the pulmonary artery with bilateral patent ductus arteriosus.


Persistent changes in the large bowel following the enterocolitis associated with Hirschsprung's disease.


Metastatic calcification of the myocardium.


Radiation therapy and the cancer problem.


Rheumatic fever. A changing disease.

Rheumatic fever. A changing disease.


Hormonal control of growth. A--excessive tallness. B--diminished stature.


Vesical neck contracture in the adult male.


The many roentgen patterns of lung cancer.


Headache due to systemic diseases.

Headache due to systemic diseases.


Delivery of personal health services. Prerequisites for improvement.


Disseminated intravascular coagulation (DIC). Diagnostic and therapeutic aspects.


Peritoneal dialysis in the community hospital.


Killing the golden goose.

Killing the golden goose.


Why moon walking is simpler than social progress.


What's your verdict?

What's your verdict?


Two minutes with diabetes.

Two minutes with diabetes.


Coroner's corner.

Coroner's corner.


Association of Minnesota Internists.

Association of Minnesota Internists.


Anesthesia after myocardial infarction.

Anesthesia after myocardial infarction.


Hepatic coma in pregnancy treated with exchange transfusion.


Coronary care in the very small hospital.


Hemolysis associated with intracardiac prostheses. Diagnosis and management.


Prolonged oxygen therapy and mechanical ventilation. Associated pulmonary abnormalities.


Pernicious anemia.

Pernicious anemia.


The human use of human machines.

The human use of human machines.


Chronic respiratory disease in children.


Skin rash and abnormal chest roentgenogram.


The neurological examination.

The neurological examination.


Some complications of hip fractures.

Some complications of hip fractures.


Leukoplakia.

Leukoplakia.


Rusty about iron metabolism?

Rusty about iron metabolism?


Penicillin hypersensitivity.

Penicillin hypersensitivity.


Corrosive esophagitis--A review of therapy.


A new low-dose combination oral contraceptive.


Embryology and abnormal anatomy of the maxillary sinus.


Implanted pacemakers; results in fifty-nine patients.


Medex; a demonstration program in primary medical care.


Rubella vaccine recommendations. AMA council on environmental and public health issues statement and reviews present knowledge in this field.


Sanity and survival.

Sanity and survival.


Work and the anorexia nervosa patient.

Work and the anorexia nervosa patient.


Evaluation and use of common psychiatric medicines.


Aspects of the practice of psychiatry in the Cincinnati area.


The use of Cordran tape in dermatology.

The use of Cordran tape in dermatology.


Successful portacaval shunt in an elderly woman.


Medical College at Toledo opens with class of 32 students.


Key medical legislation adopted by general assembly.


Wasted x-rays.

Wasted x-rays.


Treatment of arrhythmias complicating acute myocardial infarction in the coronary care unit. II.


Medical education and licensure.

Medical education and licensure.


Reach to Recovery Program. II.

Reach to Recovery Program. II.


The simple clinical evaluation of renal function.


The depressed patient and physician responsibility.


Protective value of suboptimal arterial blood pressure on renal function.


Building the hospital's legal defenses through a three-way partnership.


Diazepam during labor.

Diazepam during labor.


Light and electron microscopic study of the normal and pathological thymus of the rat. 3. A mesenchymal histiocytic type of cell.


Electron microscopic studies on the pars intermedia of the ferret.


Morphological characteristics of pituicytes in different functional stages. Light- and electronmicroscopy of the neurohypophysis of the albino rat.


Fine structure of spermatogonia and primary spermatocytes in rabbits.


Intramitochondrial inclusions in various cells of a snake (Elaphae quadrivirgata).


Occurrence of lysosomes and the differentiation of rat liver cells.


The secretory cells of the submaxillary gland in the perinatal period of development in the rat.


Granule formation in rat myeloid cells. An electron microscopic study.


The site of prolactin secretion in the adenohypophysis of the stenohaline teleost Anoptichthys jordani, and the effects of this hormone on mucous cells.


Adrenergic nerves to the dermal melanophores of the rainbow trout, Salmo gairdneri.


Ultrastructural changes in the mitochondria of the acid gland of Nasonia vitripennis (Walker) (Pteromalidae: Hymenoptera) induced by starvation.


An electron-microscopic study of the de novo formation of neuromuscular junctions in tissue culture.


Centriole replication during ciliogenesis in the chick tracheal epithelium.


Cytoplasmic filaments and morphogenesis: the role of the notochord in ascidian metamorphosis.


Intercoil connections of the kidney of the brine shrimp, Artemia salina.


The structure of oestrogen sensitized rat vagina after exposure to steroids as studied in transplants.


Synaptic relationships in the plexiform layers of carp retina.


Electron microscopic observations on a new cell type in the fundus mucosa of the mouse stomach.


The turnover of fibrinogen in aortic surgery. An experimental study in dogs.


Healing impairment in skin incisions closed with silk sutures. A tensiometric and histologic study in the rat.


Intraosseous pressures in patients with fracture of the femoral neck. Methods and preliminary findings.


Hyperparathyreoidism. Clinical observations in a series of 85 patients.


Analysis of cauda equina symptoms in patients with lumbar disc prolapse. Preoperative and follow-up clinical and cystometric studies.


Achalasia oesophagi and associated diseases.


Liver reaction as manifested in increased activity of ornithine carbamoyl transferase in serum (S-OCT) after operation in the dog.


Haemorrhagic mucosal necrosis of the gastrointestinal tract without vascular occlusion.


Proteolytic activity of nonpancreatic origin in different segments of the small intestine of rats.


Ileo-colic transit in rats subjected to ileo-caecal resection.


The application of anticipatory avoidance learning to the treatment of homosexuality. Developments in treatment technique and response recording.


General paresis; a follow-up study of 203 patients.


Serum folate in psychiatric patients under long-term treatment with tricyclic neuroleptic drugs.


Vitamin-B 12 and folic acid in psychiatric disorders.


Future time perspective and adolescent behaviour disorders.


The hospital requirement and the possibilities of occupation for schizophrenic women.


The athlete's neurosis--a deprivation crisis.


A community mental health screening procedure.


Gout and hyperuricemia in a Finnish rural population.


The morphology of the synovial tissue and articular fluid cells in rheumatoid polyarthritis--studied with the optical and electronic microscope.


The segmentation of polymorphonuclear neutrophils in rheumatoid arthritis and ankylosing spondylitis.


Rheumatoid arthritis in both marital partners.


Plasmamucoid and erythromucoid in degenerative joint diseases.


Retention of oral 47calcium in patients with rheumatoid arthritis and osteopenia.


Intra-articular injection of radioactive gold in treatment of chronic synovial effusion in the knee.


Atrial fibrillation. 3. A study of the fibrillatory waves using a new technique.


On the consequences of matching in retrospective studies with special regard to the calculation of relative risks.


Roentgenological heart volume determination in model experiments. Influence of the size, configuration and position of the heart and of the position of the diaphragm.


Roentgenological heart volume determination in model experiments. The influence of tube voltage and of the relation of the central beam to the object.


Roentgenological determination of the heart volume. The influence of projection and body position.


Ureteric pressure variations at different flow rates and varying bladder pressures in normal dogs.


The relationship between the California mastitis test, Whiteside test, Brabant mastitis reaction, catalase test, and direct cell counting of milk.


The metabolic response to norepinephrine in carbon tetrachloride poisoned sheep.


The mitotic and meiotic chromosomes of the muskrat (Ondatra zibethica L.).


Active mammary excretion of N4-acetylated p-aminohippuric acid.


Studies on crystalline lactate dehydrogenase from cardiac and skeletal muscle of plaice (Pleuronectes platessa) with particular reference to temperature.


Studies on succinate dehydrogenase. V. Inhibition by oxaloacetate.


A direct assay for liver phenylalanine hydroxylase.


Submicrosomal distribution of adrenal enzymes and cytochrome P-450 related to corticoidogenesis.


Studies on the activation in vitro of glucuronyltransferase.


Beta-1,3-glucan hydrolases from Euglena gracilis. I. The nature of the hydrolases.


The influence of a free alpha-ammonium group in the substrate upon trypsin-catalyzed transesterification.


Beta-1,3-glucan hydrolases from Euglena gracilis. II. Purification and properties of the beta-1,3-glucan exo-hydrolase.


Kinetics of the trypsin-catalyzed hydrolysis and ethanolysis of L-lysine methyl ester.


Isolation and properties of two chymotrypsins from the turtle Pseudemys elegans.


Sedimentation equilibrium studies of some turtle chymotrypsins.


Palo Verde (Parkinsonia aculeata L.) seed aminoacylase.


6-methylsalicylic acid decarboxylase from Penicillium patulum.


Purification and properties of the aromatic (arom) synthetic enzyme aggregate of Neurospora crassa.


Partial purification and some properties of bovine heart arylamidase.


Beef adrenal medulla dihydropteridine reductase.


[Determination of N-acetyl-L-aspartic acid and of its calcium salt in pharmacologic preparations] (Ita].


Metabolic myocardial lesion in uraemia and blood loss. Experimental-morphological study.


Influence of some psychotropic drugs on the development of experimental atherosclerosis.


The effect of benzonal and benzamyl on the neurogenic (neurotic) experimental hypertension in dogs.


Atrial electric activity in experimental aortic stenosis.


The septal artery and vein in canine coronary vessels. The blood flow rate through the anterior interventricular vein after ligation of the septal artery.


Vascular electric activity and secretion of tissue blood coagulation factors into total blood flow after choline chloride injection.


The septal artery and vein of the human heart.


Effect of some adrenonegative agents on collateral coronary circulation.


A model of myo- cardial infarct in dogs, through the gradual compression of the coronary vessels by rods of laminaria digitata.


The clinical position of moperone among the butyrophenones.


The adsorption of preservatives on membrane filters.


Studies on the stability of injectable L-ascorbic acid solutions. I. Effect of pH, solvent, light and container.


Recovery of motor function after unilateral infarction of the basis pontis. Report of a case.


Characteristics of head motion with variable visual feedback delay, velocity and displacement.


Pre-orthotic training: an electromyographic study in normal adults.


A simple treatment of chronic lower extremity stasis ulcers.


Isolation and partial characterization of the exocellular polysaccharides of Penicillium charlesii. 3. Heterogeneity in size and composition of high molecular weight exocellular polysaccharides.


The endogenous substrate for nuclear oxidative phosphorylation.


The metabolism of tartaric acid by Penicillium charlesii.


Action of pancreatic lipase on emulsions of water-solubl esters.


Substrate-binding properties of firefly luciferase. I. Luciferin-binding site.


Isolation and properties of a fluorescent pigent from Pseudomonas mildenbergii.


Amino acid synthesis by the mitochondria of Neurospora crassa. I. Dependence on respiration of mitochondria.


Nature of the effect of caffeine on the drug-metabolizing enzymes.


Isolation and partial characterization of manganin, a new manganoprotein from peanut seeds.


The effect of N-bromosuccinimide upon trypsinogen activation and trypsin catalysis.


The reaction of benzoquinone with amines and proteins.


Glycoproteins of Ehrlich asctes carcinoma cells. Separation of plasma and endoplasmic reticular membrane fragments.


Subcellular site of structural glycoprotein synthesis in Ehrlich ascites tumor.


Structure studies of collocalia mucoid. I. Carbohydrate and amino acid composition.


Irreversible in vivo inhibition of rat liver phenylalanine hydroxylase by p-chlorophenylalanine.


Enzymatic methylation of histones.

Enzymatic methylation of histones.


Survey of stroke patients.

Survey of stroke patients.


Separation of nucleotide-binding proteins and soluble transfer factors from extracts of calf brain.


A meteorological analysis of carbon dioxide concentrations measured at a rural location.


Some effects of the air pollutant, peroxyacetyl nitrate, upon deoxyribonucleic acid and upon nucleic acid bases.


On the relation between changing meteorological circumstances and the decrease of the sulphur dioxide concentration around Rotterdam.


On the atmospheric benzo(a)pyrene pollution in Budapest.


Hypotension, hypoventilation and delayed recovery after propanidid.


Medical applications of gas chromatography.


An autoradiographic study of placental transmission of labelled prilocaine (Citanest) in the rat.


Cardiovascular effects of epidural block combined with general anaesthesia.


Conduction anaesthesia, blood pressure and haemorrhage.


A comparison of Macrodex and stored blood as replacement for blood loss during planned surgery. 3. Red cell sequestration.


Variability of haemoglobin concentration during anaesthesia. A statistical investigation of three anaesthetic methods.


Hexafluorenium-suxamethonium relaxation for abdominal surgery.


Massive blood replacement in neonates and children.


Postoperative headache after nitrous oxide-oxygen-halothane anaesthesia.


Plasma levels of thiopentone after premedication with rectal suppositories in young children.


A re-examination of some electrocardiographic studies during hypotensive anaesthesia. The effect of rate of fall of blood pressure.


The effect of inadequate entrained gas flow on the cyclator ventilator.


The detection of skeletal metastases from mammary cancer by gamma camera scintigraphy.


Academic and professional freedom.

Academic and professional freedom.


Oral contraception and depression.

Oral contraception and depression.


Urinary symptoms in general practice.

Urinary symptoms in general practice.


Treatment with neutrons.

Treatment with neutrons.


Psychogenic dyspnoea.

Psychogenic dyspnoea.


Immunological aspects of Addison's disease.


Anaesthesia in the dark.

Anaesthesia in the dark.


Actinic reticuloid.

Actinic reticuloid.


Medical education and the state.

Medical education and the state.


Insulin sensitivity and vascular disease in maturity-onset diabetics. In 27 maturity-onset diabetics of more than 10 years' duration there was a significant tendency for both atherosclerosis and microangiopathy to be associated with a reduction in the acute hypoglycaemic effect of intravenous beef insulin. This finding is identical to that in a group of 51 insulin-dependent diabetics previously reported.It is suggested that insulin insensitivity probably precedes the appearance of vascular disease in diabetes and may be implicated in its production.


Association of hypokalaemia and hypophosphataemia. A prospective study of 13 patients with hypokalaemia due to a variety of causes demonstrated that six had hypophosphataemia. In 10 patients the plasma inorganic phosphate level rose on correction of the hypokalaemia. Before treatment seven patients had an excessive rate of excretion of phosphate relative to creatinine in the urine. Following correction of the hypokalaemia 11 patients had an increase in renal tubular reabsorption of phosphate relative to creatinine. It is suggested that hypokalaemia may be causally related to the hypophosphataemia, and that in chronic potassium depletion this may affect bone mineralization.


Involuntary movements in patients taking oral contraceptives. Involuntary movements developed in five women taking oral contraceptives. In one, the sudden onset of a unilateral disturbance suggested a cerebral thrombosis; this case is considered to be a further example of the increased risk of cerebrovascular disease associated with oral contraception. The four other patients suffered a relapse of Sydenham's chorea between one and four months after starting an oral contraceptive regimen. Possibly an underlying vascular mechanism was responsible for these relapses.


Transient hypertension caused by segmental renal artery occlusion.


Migraine.

Migraine.


Spinal injuries and fractures.

Spinal injuries and fractures.


Cogwheel: a physician's view of a local version. A preliminary experiment in the divisional system of medical administration has been started in a large regional hospital in the Metropolitan area. This has involved considerable local interpretation of the original proposals in the Joint Working Party's report. The chief benefits of this version as tried so far have been a more effective use of doctors' time at all levels, a more rapid carrying out of practical suggestions, and closer co-operation between different departments. Those who give first administrative place to streamlined efficiency have seen the absence of an authoritative executive committee as the chief defect to date. The main fault in the eyes of those who emphasize the fundamental importance of participation has been the delay in the involvement of the junior medical staff.


Emergency admissions to a general medical unit: a survey of the accompanying letters, with recommendations. Letters of referral accompanied 166 out of 188 emergency admissions to a general medical unit over a four-month period. Of these, 129 contained useful information concerning past medical history, emergency treatment given, drugs taken, and provisional diagnosis. It is suggested that general practitioners should adopt some format based on essential criteria when writing letters of referral, so that important information is not overlooked.


Mobile coronary care teams.

Mobile coronary care teams.


Vaccination against whooping-cough.

Vaccination against whooping-cough.


Malignant granuloma.

Malignant granuloma.


Purpura and ibuprofen.

Purpura and ibuprofen.


Metabolism in Parkinsonian patients.

Metabolism in Parkinsonian patients.


Methoxyflurane for obstetric analgesia.

Methoxyflurane for obstetric analgesia.


Survival after 195 defibrillations.

Survival after 195 defibrillations.


Congenital anomalies of the vas deferens.


Paternity test refused.

Paternity test refused.


Cancer from mineral oil.

Cancer from mineral oil.


A new synthetic antimycotic.

A new synthetic antimycotic.


D.D.T. in the environment.

D.D.T. in the environment.


Plutonium for pacemakers.

Plutonium for pacemakers.


The desmoid tumour.

The desmoid tumour.


Mental disturbance in doctors.

Mental disturbance in doctors.


Primary amoebic meningoencephalitis in Britain. Primary amoebic meningoencephalitis is caused by amoebae of the genera Naegleria and Hartmannella (Acanthamoeba), which ordinarily are free-living saprophytes. The infection may be acquired from fresh water-for example, while bathing-the amoebae invading the nasal mucosa and reaching the meninges and brain along the olfactory nerve filaments. The disease is designated "primary" to distinguish it from meningocerebral infection caused by the parasitic amoebae, particularly Entamoeba histolytica, which invade the central nervous system only as a result of dissemination in the blood stream from lesions in other parts of the body.During histological reappraisal of old specimens in a medical museum in London an instance of amoebic meningoencephalitis histologically indistinguishable from the published cases has been found. The specimen dates from 1909. The patient was said to be from Essex. What may have been another case, seen in Northern Ireland in 1937, is also described briefly. These observations may indicate that this disease occurs in the British Isles.Primary amoebic meningoencephalitis should be considered in the differential diagnosis of every case of acute meningitis.


Frequencies of secretors and non-secretors of ABH group substances among 1,000 alcoholic patients. The ABO blood group and secretor status of 1,000 alcoholic patients has been determined. The patients were drawn from large alcoholic units in the London area together with several small units, including rehabilitation centres, nd 127 were from Aberdeen.The findings have been compared with appropriate controls which take into account the ethnic origin of the patients in the series. A striking disturbance of the secretor/non-secretor ratio among group A patients compared with the controls is observed. There is an increase in group A non-secretors, which is almost exactly balanced by a loss of group A secretors so that the overall frequency of the group A phenotype is not disturbed. It is difficult to find an acceptable explanation for these results.


Severe haemolytic anaemia in pregnancy in Nigerians treated with prednisolone. Haemolytic anaemia of obscure aetiology is a common complication of pregnancy in Nigeria. Treatment with antimalarials and folic acid is usually followed by a rapid remission, but response is slow in about 25% of patients and haemolysis continues uncontrolled in about 5%. The administration of prednisolone to six patients with uncontrolled haemolysis was followed by rapid recovery in five and possible benefit in one. Risks of prednisolone therapy to the mother appear to be slight and outweighed by the risks of continued severe anaemia and frequent blood transfusions. There seemed to be no appreciable increase of fetal loss compared with that in anaemic pregnancies not treated with prednisolone.


Deaths in children with acute appendicitis. Two hundred and four children died of acute appendicitis in England and Wales in the five-year period 1963-7. The mortality rate in children less than 5 years old was eight times higher than that in those aged 5-14. It is suggested that diagnosis, intravenous therapy, treatment of convulsions and hyperpyrexia, and anaesthesia are fields where there is room for improvement in management. Moreover, there is a place for the wider use of national medical audits on the lines of the Confidential Enquiry into Maternal Deaths.


Management of pregnancy in a woman with Hb H disease.


Extrication of trapped casualties.

Extrication of trapped casualties.


Spring-loaded dissecting clamp.

Spring-loaded dissecting clamp.


First-aid training.

First-aid training.


Programme for specialization in family medicine. A programme for specialized training in family medicine at Tel Aviv University Medical School provides four years of postgraduate study, two of which are in recognized hospital departments and two in clinics recognized for training in family medicine. At the end of this four-year period the graduate must submit a thesis of original work or an approved research project on an aspect of family medicine. Continuing contact of the trainee with both the family medicine clinic and the hospital departments is maintained throughout the period. While in hospital the trainee spends half a day a week in the family clinic with his personal tutor, and when in the clinic he spends half a day a week in the hospital.This programme has been provisionally accepted as meeting the formal requirements of the Israel Medical Association for specialization in family medicine, and the first physician has started training.


Fluid therapy during surgery.

Fluid therapy during surgery.


Rhesus sensitization and abortion.

Rhesus sensitization and abortion.


Delayed phenytoin idiosyncrasy.

Delayed phenytoin idiosyncrasy.


Tests for cancer.

Tests for cancer.


Nasal obstruction in babies.

Nasal obstruction in babies.


Research into clinical endocrinology.

Research into clinical endocrinology.


Respiration and heart rhythm.

Respiration and heart rhythm.


Herpes gestationis.

Herpes gestationis.


Administration and the structure of scientific knowledge.


Absorption of therapeutic preparations of iron measured with a whole body counter. The Oxford Whole Body Counter was used to measure absorption from various therapeutic preparations of iron in five groups of subjects. Succinic acid enhanced absorption of iron when added to a solution of ferrous fumarate, but not when given with tablets of ferrous fumarate or ferrous sulphate. Ferrous fumarate plus ascorbic acid was absorbed better than ferrous fumarate alone but no better than ferrous sulphate. The addition of ascorbic acid and succinic acid to tablets of ferrous sulphate did not enhance absorption significantly.


Pancreatic calcification: a report of 45 cases. Forty-five cases of pancreatic calcification are reported, and it is shown that in Western Nigeria this malady afflicts younger people than in Europe and the United States of America. Males and females seem about equally affected in Western Nigeria, whereas it predominantly affects males in France, Britain, and North America. Diabetes mellitus was the commonest complication in this series, and brought many patients to the doctor. In this series chronic relapsing pancreatitis was a rare cause; there was no history of alcoholism; and protein malnutrition was thought to be responsible for pancreatic calcification in over 90% of the patients.


Case of extreme hypersensitivity to almost all antituberculous drugs.


Device for continuous monitoring of cerebral activity in resuscitated patients.


Parkinsonism.

Parkinsonism.


Mass disaster schemes.

Mass disaster schemes.


Purgatives.

Purgatives.


Bronchodilator aerosols.

Bronchodilator aerosols.


Involuntary movements and the pill.

Involuntary movements and the pill.


Alternative to neostigmine for megacolon.


Unusual effect of fenfluramine.

Unusual effect of fenfluramine.


Treating erythema nodosum.

Treating erythema nodosum.


A modest proposal.

A modest proposal.


Sugar and ischemic heart disease.

Sugar and ischemic heart disease.


Antibiotics prolong salmonella excretion.


Cause for concern.

Cause for concern.


Prolonged pregnancy.

Prolonged pregnancy.


Phenacetin and bladder cancer.

Phenacetin and bladder cancer.


Pulmonary sensitivity to nitrofurantoin.


Some international trends in sickness absence 1950-68. Annual sickness absence rates in Great Britain since 1950 have been compared with similar measurements obtained from eight other countries. Frequency has tended to rise more than severity, indicating a shortening of the average length of a spell. The rise in British rates is not unique, and has been exceeded in Sweden, Holland, Italy, and West Germany. From the Swedish experience with self-certification some caution is necessary before recommending its adoption in Britain.


Hypothalamic-pituitary-adrenal function after subarachnoid haemorrhage. In 18 patients with a ruptured aneurysm of the anterior communicating artery on the circle of Willis hypothalamuc-pituitary-adrenal function has been assessed by the diurnal variation in plasma cortisol levels and by the response to metyrapone, dexamethasone, and pyrogen. Eleven patients had an abnormal diurnal variation, seven had an abnormal response to metyrapone, and eight had an abnormal response to dexamethasone. All who were given pyrogen reacted normally to this stress. Two patients who died had lesions in the anterior hypothalamus, and it is suggested that this localization of lesions was responsible for the pattern of pituitary-adrenal dysfunction which was observed. An improvement in function was seen in many patients after an interval of a month.


Changes in blood gas tensions and functional residual capacity chronic asthmatics treated with disodium cromoglycate. Twenty chronic asthmatic subjects were treated with disodium cromoglycate in open trial. Although in the group as a whole spirometric findings improved, some patients showed a significant increase in arterial oxygen tension or a significant fall in functional residual capacity without any appreciable changes in spirometry. These changes may partly explain the clinical efficacy of this drug.


Renal excretion of calcium and sodium in acute nephritis. Hypocalciuria was found in the early stages of illness in six patients aged 12 to 30 with acute nephritis. The hypocalciuria does not appear to be due to hypocalcaemia, lowered glomerular filtration rate, or hypoparathyroidism. It is suggested that the hypocalciuria is due in part to decreased intestinal absorption of calcium, though possibly there is also a primary alteration in renal tubular handling of calcium.


Handling of induced hypercalcaemia in hyperthyroidism. The mean serum calcium of 13 hyperthyroid patients was found to be significantly higher than that of controls matched for sex and age, though none of the patients' values were outside the normal range. Nevertheless, these patients responded very promptly to hypercalcaemia (induced by an intravenous calcium load), and their serum calcium returned to normal much more rapidly compared with the matched controls. There was also increased retention of intravenous calcium load, possibly owing to increased calcitonin production. Calcium infusion may be useful in treating bone diseases in which increased bone resorption exceeds bone accretion.


Maintenance of silastic-teflon shunts for intermitten haemodialysis. The occurrence of infection in the tissues surrounding external arteriovenous shunts was studied and die important relationship of pyogenic infection to clotting was confirmed. The local application of fusidic add tulle and lanolin greatly reduced the occurrence of both infection and clotting and the need for cannula replacement.Urokinase used for declotting shunts when standard procedures had failed, restored blood flow whether dotting was related to infection or to local vascular factors. This treatment is not advised when clotting is associated with a local abscess, as it may make cannula replacement necessary. Severe local vascular factors, such as metastatic calcification, Raynaud's phenomenon, and venous stenosis, may lead to poor blood flow, so that despite clot lysis elective cannula replacement or the creation of a subcutaneous arteriovenous fistula is required.


A case of sarcoidosis with cryptococcal meningitis demonstrated at the Royal Postgraduate Medical School.


Scandinavian developments in general practice.


Effect on airways resistance of prostaglandin E1 given by aerosol to healthy and asthmatic volunteers. The forced expiratory volume in one second (F.E.V.(1)) was measured in healthy and asthmatic volunteers and the inhalation of prostaglandin E(1) (PGE(1)) was compared with that of isoprenaline, using metered aerosols.In healthy volunteers PGE(1), either as the free acid or the neutral triethanolamine salt, did not affect the F.E.V.(1); the free acid was irritant to the upper respiratory tract. In five out of six asthmatic volunteers with reversible airways obstruction, inhalation of 55 mug of PGE(1) (triethanolamine salt) produced an increase in F.E.V.(1) comparable in both degree and duration to that produced by an inhalation of 550 mug. of isoprenaline sulphate.Though the triethanolamine salt was well tolerated in most of the asthmatic subjects studied, in one asthmatic subject this preparation caused coughing and there was a progressive reduction in the F.E.V.(1) associated with bronchospasm.


Freezing and antilymphocytic globulin.

Freezing and antilymphocytic globulin.


Oral contraceptives containing oestrogens.


Damages for reaction to vaccine.

Damages for reaction to vaccine.


Feto-maternal bleeding and hypertension in pregnancy.


Evaluation of screening methods for carcinoma of the large bowel: based on a cytologic study of rectal smears using fluorescence microscopy.


Further studies of the kinetics of rectal epithelium in normal subjects and patients with ulcerative or granulomatous colitis.


A transrectal approach to the high-lying lesion in the rectosigmoid.


The relation between the Epstein-Barr virus and infectious mononucleosis, Burkitt's lymphoma and cancer of the postnasal space.


Infectious mononucleosis in East Africa.


Association of Burkitt's tumour and holoendemic malaria in West Nile District, Uganda: malaria as a possible aetiologic factor.


Volvulus of the colon.

Volvulus of the colon.


A report on two African children with pseudohypertrophic muscular dystrophy.


Antiperistaltic displacement of an ileal loop without twisting its mesentery.


An evaluation of the amebicidal properties of metronidazole.


Regulation of the rate of amino acid incorporation into protein by rat liver cell sap components.


Induction of spawning and oocyte maturation by L-methyl-adenine in starfishes.


In vivo measurement of dimensions of veins with implications regarding control of venous return.


Wall properties of veins.

Wall properties of veins.


Treatment of acquired megacolon by retrorectal lowering of the colon with a perineal colostomy: modified Duhamel operation.


Primary perineal hernia.

Primary perineal hernia.


Long-term survival after left liver lobectomy.


The transmission characteristics of large and small pressure waves in the abdominal vena cava.


Primary adenocarcinoma of the appendix.

Primary adenocarcinoma of the appendix.


Diverticulitis--a case reflecting upon pathogenesis.


Flow through collapsible tubes and through in situ veins.


Pressure--flow relationships in collapsible tubes.


Free perforation in sigmoid diverticulitis: two-stage therapy.


A mathematical model for the pressure-flow relationship in a segment of vein.


An integrated approach to the study of the venous system with steps toward a detailed model of the dynamics of venous return to the right heart.


Computer simulation studies of the venous circulation.


Difficulties in the further development of venous hemodynamics.


A light source for pupil stimulation.

A light source for pupil stimulation.


Synchronous initiation of paced pressure and flow signal recordings.


Accidental deaths among children.

Accidental deaths among children.


Growth pattern in children with congenital heart disease.


Liver disease in children. An autopsy study.


Magnesium levels in serum and cerebrospinal fluid of normal children.


Congenital hemihypertrophy.

Congenital hemihypertrophy.