Bone and derivatives of bone for repair of skeletal defects.


Complement fixing and tissue binding serum globulins in patients with myasthenia gravis, and their relation to muscle ribonucleoprotein.


Immunofluorescent localization of bacterial antigen in pyelonephritis. I. The use of antisera against the common enterobacterial antigen in experimental renal lesions.


The long-term evaluation of a trial of immediate and delayed closure of spina bifida cystica.


Significance of lactase deficit in ulcerative colitis.


Francis Clark Wood--a tribute.

Francis Clark Wood--a tribute.


Separations of lipids by silver ion chromatography. The possibility of separating lipid materials on the basis of the number, type, and position of the unsaturated centers they contain, by virtue of the complexing of these unsaturated bonds with silver ions, provides a relatively recent but now very important addition to the range of separatory methods available to lipid chemists and biochemists. In this review, the nature of the complexing of silver ions with olefins is considered briefly and the history of the development of separation methods based on argentation is traced. Some practical considerations of argentation chromatography are discussed and separations of fatty acids and aldehydes, substituted fatty acids, neutral lipids, polar lipids, and sterols and other terpenoid compounds, by argentation methods alone and in conjunction with other separation techniques, are then reviewed. Some conclusions are finally presented as to the present and potential utility of argentation methods in studies of the occurrence, metabolism, and function of lipids.


Quinidine--a re-evaluation.

Quinidine--a re-evaluation.


Biochemical aspects of blood coagulation and hemostasis.


Constrictive (restrictive) pericarditis.


Distinct varieties of osteogenesis imperfecta.


Examination of synovial fluid as a diagnostic aid in arthritis.


Spina bifida in the rabbit.

Spina bifida in the rabbit.


Some common allergic emergencies.

Some common allergic emergencies.


The increasing problem of photosensitivity.


The artificial kidney: some approaches to improved design and function.


Clinical disorders of acid-base regulation. A survey of seventeen years' diagnostic experience.


The role of the microbiological laboratory in the management of bacterial infections.


The clinical use of thyroid hormones.

The clinical use of thyroid hormones.


The treatment of tuberculosis.

The treatment of tuberculosis.


Stress ulcer: etiology, diagnosis and treatment.


The therapy of advanced female breast cancer. An appraisal of the present status and problems.


Molecular uniformity in biological catalyses. The enzymes concerned with firefly luciferin, amino acid, and fatty acid utilization are compared.


Experimental intravascular clotting.

Experimental intravascular clotting.


The role of steroid hormones in the etiology and pathogenesis of cancer.


A method for the easy combination of several methods of examination for tubal patency.


Experimental production of gastric ulcers in swine by reserpine.


A comparative study of single and multiple respiratory infections in the chicken: single infections (with Mycoplasma gallisepticum and Newcastle disease virus).


Virus pneumonia of pigs: filtration and visualization of a causative agent.


Effect of diethylstilbestrol, prednisolone, and isoniazid on the healing rate of bone defects filled with certain bone grafting materials.


Physiologic and clincical observations on furosemide and ethacrynic acid.


Therapy with combinations of diuretic agents: comparative studies.


A review of human cholesterol metabolism.


The surgeon cardiologists of the 19th century (Allan Burns, Joseph Hodgson, Robert Adams, James Wardrop, O'Bryen Bellingham).


Determination of pulmonary blood volume by injection into pulmonary artery and sampling in left atrium.


Musculo-skeletal disorders after renal transplantation.


Dip-slide: an aid to quantitative urine culture in general practice.


Virus antibodies in subacute sclerosing panencephalitis: a study of 22 patients.


Pathology in Britain in the first half of the twentieth century, with a glance forward.


Isolated nuclear membranes.

Isolated nuclear membranes.


The human cochlea during development and ageing.


A controlled study evaluation of adeno-tonsillectomy in children.


The Lister Institute of Preventive Medicine 1891-1966.


Spheroplast production in thymine starvation.


Pteridine content of some photosynthetic bacteria.


Alkaline phosphatase activity from Escherichia coli grown on selenite media.


Serum fraction requirements of Mycoplasma gallisepticum.


Biosynthesis of 3-ethylthiopropionic acid and degradation of ethionine by Escherichia coli.


A factor from E. coli required for the translation of natural messenger RNA.


Specific inactivation of infectious lambda DNA by sonicates of restrictive bacteria with R factors.


The preparation and characterization of ribonucleic acid obtained by direct phenol extraction of intact cells of Escherichia coli from low ionic environment.


Initiation of protein synthesis II. A convenient assay for the ribosome-dependent synthesis of N-formyl-C14-methionylpuromycin.


Pepsinogen C and pepsin C. Further purification and amino acid composition. Pepsinogen C and pepsin C from the pig have been further purified by chromatography on DEAE-cellulose and by exclusion chromatography and the specific activities (with haemoglobin substrate) found are higher than those previously reported. The final preparations are homogeneous on electrophoresis in starch gel at three pH values except for contamination with less than 4% of pepsinogen and pepsin respectively. Pepsinogen C, like pepsin C, contains no phosphate. The amino acid compositions show some marked differences from those of pepsinogen and pepsin especially in the content of basic amino acids, glutamic acid, aspartic acid, leucine and isoleucine. The molecular weights of the enzyme and zymogen, obtained from the amino acid compositions, are 41400 and 36000 respectively, similar to those of pepsinogen and pepsin.


The protein coating of asbestos bodies.

The protein coating of asbestos bodies. 1. Asbestos bodies were isolated from human lungs and the amino acid composition of the protein content was determined. 2. The hydroxyproline, glycine, leucine and phenylalanine values indicate that the protein in the coating cannot be principally collagen. 3. Albumin can be adsorbed on chrysotile asbestos as a monolayer but more than a monolayer is adsorbed if iron is also adsorbed. 4. Ferritin is adsorbed on chrysotile to give a thick layer. 5. The amino acid composition and adsorption studies are discussed in the light of the suggestions that the protein coating of asbestos is collagen (Beattie, 1961) or ferritin (Davis, 1964).


Aspartate carbamoyltransferase from rat liver. 1. Aspartate-carbamoyltransferase activity was concentrated from rat-liver preparations. Only l-aspartate, beta-benzyl-l-aspartate and beta-erythro-hydroxy-dl-aspartate were carbamoylated enzymically. The K(m) for l-aspartate and carbamoyl phosphate have been determined by three methods: colorimetric procedure, radioactive assay with [(14)C]aspartate and an assay with [(14)C]carbamoyl phosphate. 2. The K(m) for aspartate has been determined as a function of the pH; the pK of the functional group at the active site of the enzyme, pK(e), was at pH9.0. Enzymic activity was diminished in the presence of N-ethylmaleimide, p-hydroxymercuribenzoate and the heavy metals Ag(+), Hg(2+), or Zn(2+). The inhibitions could be prevented by mercaptoethanol. These findings suggested the association of a thiol group with the enzymic activity. 3. Enzymic activity was also decreased by sodium lauryl sulphate, urea and dioxan. Competitive inhibition (with l-aspartate) was manifested by maleate, succinate, oxaloacetate, beta-erythro-hydroxy-dl-aspartate and beta-benzyl-l-aspartate. The K(i) for most of these inhibitions has been determined. 4. The properties of the liver enzyme are compared with those of Escherichia coli aspartate carbamoyltransferase and the implications of the findings are discussed.


The effect of high ionic strength on the sedimentation properties of the biologically active component of bacterial ribonucleic acid. 1. The sedimentation properties of the fraction of bacterial RNA which stimulates the incorporation of amino acids into acid-insoluble material in vitro depend on the ionic strength of the sedimentation medium. 2. The different distributions of stimulatory activity found in centrifuged linear sucrose gradients loaded with bacterial RNA and containing 0.1m- or 0.6m-sodium chloride resemble closely the different sedimentation profiles of rapidly labelled RNA observed under the same conditions. 3. These findings agree with those of previous work of a similar nature (Willson & Gros, 1964) and demonstrate that the component of bacterial RNA preparations which stimulates the incorporation of amino acids into acid-insoluble peptides in vitro is contained in their rapidly labelled fraction.


Experimental lathyrism--a molecular disease.


Bicarbonate-dependent cleavage of adenosine triphosphate and other reactions catalyzed by Escherichia coli carbamyl phosphate synthetase.


Control of Escherichia coli carbamyl phosphate synthetase by purine and pyrimidine nucleotides.


On the mode of action of fusidic acid.

On the mode of action of fusidic acid.


Vascular architecture of the placentome in the cow and rabbit.


Experimental leptospirosis in pregnant ewes. VI. Immunofluorescence in the diagnosis of fetal leptospirosis.


Parapsychology and its implications.

Parapsychology and its implications.


ESP and memory.

ESP and memory.


Extrasensory perception research in Russia and Czechoslovakia.


A scientific critique of parapsychology.


Parapsychology: old delusion or new science?


Isolation of metaphase chromosomes from HeLa cells. The authors have developed a method for large-scale isolation of metaphase chromosomes from HeLa cells. The distinguishing feature of this method is the use of a pH sufficiently low (about 3) to stabilize the chromosomes against mechanical damage. Many milligrams of fairly pure, morphologically intact chromosomes can be isolated in 8 hr or less of total working time. The isolated chromosomes contain about 2.0 mg of acid-soluble protein, 2.7 mg of acid-insoluble protein and 0.66 mg of RNA for each milligram of DNA. The RNA bound to the isolated chromosomes consists mainly of ribosomal RNA, but there is also a significant amount of 45S RNA.


Symposium on Karl Bühler's contributions to psychology.


Electrophysiological study of special connections between cells in the early chick embryo.


Perception of finger drawings upon the body surface.


2-aminotyrosine, an analog of tyrosine.

2-aminotyrosine, an analog of tyrosine.


Preparation and antibacterial activity of some spiramycin derivatives.


Preparation of substituted phenethyl alcohols and a study of their bacteriostatic action in Escherichia coli B.


Induction of body image boundary changes.


Cholinergic mechanisms in the caudate nucleus. 1. Acetylcholine (ACh), and a number of cholinomimetic and cholinolytic agents, have been applied to single neurones of the caudate nucleus, and the effects compared with those produced by stimulation of nucleus ventralis anterior thalami (VA).2. Neurones responding by excitation following ACh and VA stimulation, and others depressed by both ACh and VA stimulation have been observed. The two types of cell are located in different regions of the nucleus.3. Both types of ACh effect, and the responses to VA stimulation, are prevented by atropine.4. Taken with the earlier observation that the release of ACh from the caudate can be enhanced by VA stimulation, it has been suggested that the present results indicate a final cholinergic link in the pathway from VA to caudate.


Body boundary and achievement behavior.

Body boundary and achievement behavior.


The human content response in the Holtzman Inkblot Technique.


Perceptual organization: a developmental analysis by means of the Holtzman Inkblot Technique.


Test equivalence of projective and structured self-concept instruments.


Figure drawing correlates of furlough utilization in an aged institutionalized population.


Normal adult differentiation patterns on the figure drawing test.


Effect of puromycin on ribosomal particles from Streptococcus pyogenes.


Urinary amines in chronic schizophrenia.


Use of radioactive isotopes in studies on phagocytosis in vitro.


Capacity of pepsin-digested antibody to inhibit antibody formation.


A comparison of methods used for the microbiological examination of poultry carcasses.


The origin of the right aortic nerve in the rabbit.


Hangover effect of secobarbital on simulated pilotage performance.


Selective inactivation of the glutamine binding site of Escherichia coli carbamyl phosphate synthetase by 2-amino-4-oxo-5-chloropentanoic acid.


The reaction of diazonium-1H-tetrazole with proteins. Determination of tyrosine and histidine content.


Tetranitromethane. A reagent for the nitration of tyrosyl residues in proteins.


The polynucleotide product of poly A polymerase from Escherichia coli.


The relationship between poly A polymerase and the ribosomes.


Aspartate transcarbamylase from Escherichia coli. II. Interaction of metal ions with substrates, inhibitors and activators.


Limited genome expression in bacteriophage T4-infected Escherichia coli.  I. Demonstration of the effect.


Limited genome expression in bacteriophage T4-infected Escherichia coli. II.  Development and examination of a model.


Sidney Tarachow, M.D. 1908-1965.

Sidney Tarachow, M.D. 1908-1965.


Robert Palmer Knight 1902-1966.

Robert Palmer Knight 1902-1966.


Radiocarpal arthrodesis: a surgical approach to brachial paralysis.


Nonsense codons and polarity in the tryptophan operon.


Effect of ribosomes on the biosynthesis of ribonucleic acid in vitro.


Classification of aminotransferase (C gene) mutants in the histidine operon.


Comparative kinetics of synthesis of transfer RNA and 5 s RNA in bacteria and mammalian cells.


Myogenesis: fusion, myosin synthesis, and the mitotic cycle.


Two L-asparaginases from E. coli and their action against tumors.


On the relation between ribonucleic acid synthesis and peptide chain initiation in E. coli.


Initiation of protein synthesis,I. Effect of formylation of methionyl-tRNA on codon recognition.


Urinary tract infection in a general surgical unit.


Urinary metabolites of aldosterone in the guinea pig.


Fixation of aortic ball valve prosthesis (Starr-Edwards).


Immunohistochemical localization and bacteriostatic properties of an iron-binding protein from bronchial mucus.


Tracheal resection with left lung anastomosis following right pneumonectomy.


President of the British Veterinary Association 1966-67.


Homotransplantation of the lung in dogs, with special reference to the circulation system in the transplant.


Intraarticular prednisolone injection for osteoarthritis of the knee. A double blind test with placebo.


The surgical management of myelomeningocele with a preliminary report of 31 cases.


Sprained ankles. VI. Surgical treatment of "chronic" ligament ruptures.


ABO blood group, secretor status and gastric secretion.


The contributions of Franz Josef Kallmann to the genetics of schizophrenia.


Comparative studies on the toxicity of Escherichia coli lipopolysaccharide endotoxin in various animal species.


Sampling from a modified Torbal anaerobic jar.


Tissue transplantation immunity in the adult newt, Diemictylus viridescens. I. The latent phase: healing, restoration of circulation, and pigment cell changes in autografts and allografts.


Tissue transplantation immunity in the adult newt, Diemictylus viridescens. II. The rejection phase: first- and second-set allograft reactions and lack of sexual dimorphism.


Identification of counterfeit drugs, particularly barbiturates and amphetamines by microscopic, chemical, and instrumental techniques.


Mr. T. Twistington Higgins.

Mr. T. Twistington Higgins.


Degloving injuries in children.

Degloving injuries in children.


The genetic constitution of the radiation-sensitive mutant Escherichia coli Bs-1.


Properties of four mutants of Escherichia coli defective in genetic recombination.


Development and evaluation of an impedance cardiac output system.


Potential microbic shock in manned aerospace systems.


Gastric pepsin, mucus and clinical secretory studies. I. Gastric pepsin and pepsin inhibitors. Comparative studies on the structure and specificity of human gastricsin, pepsin and zymogen.


Comparison of estimated peptic activity by RISA and the hemoglobin methods of crystalline pepsin solutions, of human gastric secretions and sulfated polysaccharides.


Gastric pepsin, mucus and clinical secretory studies. II. The role of the mucous barrier in the defense of the stomach vs. peptic ulceration. Carbohydrate histochemistry of gastric epithelial secretions in dog. Chemistry of the secretion layer.


Current status of the "glandular mucoprotein" and "mucoproteose" fractions of the gastric mucin: a review of 15 years progress in this area.


Effect of a synthetic sulfated polysaccharide (SN-263) on gastric peptic activity in humans.


Physicochemical properties of gastric mucus and its role in the pathogenesis of gastric lesions.


The ABO blood group antigens and their secretion by healthy and diseased gastric mucosa.


The determination of intrinsic factor in gastric secretory analysis.


Keratodermia palmaris et plantaris.

Keratodermia palmaris et plantaris.


Plastic reconstruction of the upper eyelid.


The fetal electrocardiogram in a case of conjoined twins.


Pathology of posterior polymorphous degeneration of the cornea.


Acute hemodynamic effects of methoxamine in man.


Christmas in July.

Christmas in July.


Spina bifida cystica: a follow-up survey.


Sex determination, sexual differentiation and intersex development.


The effect of diazepam (Valium) in children with cerebral palsy: a double-blind study.


Treatment of status epilepticus with diazepam.


The mechanism of thalidomide deformities correlated with the pathogenic effects of prolonged dosage in adults.


Prognosis for paralysis in myelomeningocele.


Chlorzoxazone (paraflex) in the treatment of severe spasticity.


Remote-controlled stopcock and self-rinsing syringe used in cardiovascular studies.


Hemivertebrae in identical twins with dissimilar spinal columns.


The immune response of the bovine species infused intramammarily with a semi-purified preparation of the flagella of Salmonella bacteria.


Histidine regulatory mutants in Salmonella typhimurium. I. Isolation and general properties.


Histidine regulatory mutants in Salmonella typhimurium II. Histidine regulatory mutants having altered histidyl-tRNA synthetase.


Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine.


Inhibition of tRNA methylases in lysogenic organisms after induction by ultraviolet irradiation or by heat.


Direction of reading the genetic message in reticulocytes.


Polymorphism in fibrinogen aggregates.

Polymorphism in fibrinogen aggregates.


F (x).

F (x).


The varying picture in gout.

The varying picture in gout.


The effect of proteolytic enzymes on isolated adipose cells.


A simple method for quantitative urine culture.


"Physiologic" hyperbilirubinemia in the neonatal period.


Dietary fats, carbohydrates and atherosclerotic vascular disease.


Enrique González Martínez.

Enrique González Martínez.


Diploma pograms in nursing accredited by the National League for Nursing. School year: September 16, 1967-September 15, 1968.


Puppets teach young patients.

Puppets teach young patients.


Blue nevus of the oral cavity. Review of the literature.


Fine structure of soft carious dentine.

Fine structure of soft carious dentine.


Breast reconstruction after radical mastectomy for cancer.


Human renal transplantation with donor selection by leukocyte typing.


The geriatric amputee and the Medicare Act.


Resin-reinforcing technique for sectioning gallstones.


Memorial. John Charles Leonard, M.D.

Memorial. John Charles Leonard, M.D.


Parental recognition of young in cichlid fishes.


Sir George Halliday.

Sir George Halliday.


The nature of the ribonucleic acid of isolated chloroplasts.


Control of one-carbon metabolism in a methionine-B12 auxotroph of Escherichia coli.


Enzymatic synthesis of cystathionine by extracts of spinach, requiring O-acetylhomoserine or O-succinylhomoserine.


The structures of xylosylserine and galactosylxylosylserine from heparin.


Effects of glucose concentration on incorporation of [3H]leucine into insulin using isolated mammalian islets of Langerhans.


Studies on the end product regulation of aspartate kinase in certain strains of Escherichia coli.


Repressive control of potassium transport in Escherichia coli.


Small vessel anastomosis. A comparison of suture techniques.


Surgical treatment of breast hypertrophy.


Gangrene of the scrotum: an analysis of ten cases.


Amniotic fluid volumes.

Amniotic fluid volumes.


Immunology of the cancer cell.

Immunology of the cancer cell.


A comparison of the mono- and diphosphonucleotides of a group C Streptococcus and its rough variant.


The effect of amino acid analogues on alkaline phosphatase formation in Escherichia coli K-12. I. Substitution of triazolealanine for histidine.


Clarence W. Muehlberger 1896-1966.

Clarence W. Muehlberger 1896-1966.


Stretch separation of epidermis.

Stretch separation of epidermis.


Fatal myocarditis associated with ECHO virus, type 22, infection in a child with apparent immunological deficiency.


Tribute to Naomi M. Kanof, M.D.

Tribute to Naomi M. Kanof, M.D.


Medicolegal aspects of teratology.

Medicolegal aspects of teratology.


The stiffness of palatal mucoperiosteum.


Internal resorption and crown preparation.


Considerations of the check record in complete denture construction.


Non-directive psychotherapy: a little girl talks to herself. I.


Non-directive psychotherapy: a little girl talks to herself. 2.


Emotional and conceptual responsiveness of schizophrenics and normals in a projective drawing technique.


Effect of botulinum toxin on autonomic nerves in a dually innervated tissue.


Motor skills bibliography. LV. Psychological Abstracts, 1966, volume 40, second third.


Comparison of several methods of scoring draw-a-person tests.


Perception  bibliography. 37. Psychological Index No. 33, 1926.


Motor skills bibliography. LVI. Psychological Abstracts, 1966, Volume 40, third third.


Perception bibliography. 38. Psychological Abstracts, 1927, Volume 1.


Surgery of the paralysed and flail shoulder.


Mitral valve replacement with a discoid prosthesis.


Surgical repair of leaking prosthetic heart valves.


Surgical treatment of isolated cardiac valve lesions in children.


Differentiation of limb grafts in the nervous system of the chick embryo.


Evaluation of ethylene as an air pollutant affecting plant life.


Aerosol studies with avian mycoplasma. I. Survival in the air.


Biochemical and serological studies of avian strains of Escherichia coli.


Aerosol studies with avian mycoplasma. 2. Infectivity of Mycoplasma gallisepticum for chickens and turkeys.


Hormonal mechanisms in carcinogenesis.

Hormonal mechanisms in carcinogenesis.


Metabolites of carcinogens.

Metabolites of carcinogens.


The role of biotin-dependent carboxylations in biosynthetic reactions.


Bladder cancer.

Bladder cancer.


Messenger RNA and the synthesis of specific protein.


Hormonal factors in the etiology and treatment of breast cancer.


Manifestations of virus-specific antigens in virus-induced tumor cells. Theoretical and practical considerations.


In search of hormonal factors as an aid in predicting the outcome of breast carcinoma.


Epidemiology and cancer.

Epidemiology and cancer.


Neural relationships in pituitary function.


Interactions among hormonal, viral, and genetic factors in mouse mammary tumorigenesis.


X-irradiation of the homologous corneal donor material.


Review of postoperative endophthalmitis. Montreal General Hospital--1955-1964.


Electroencephalography in criminology.

Electroencephalography in criminology.


The history of communication as it relates to psychiatry.


Defects of medical education.

Defects of medical education.


Electron microscopic studies on the secretory mechanism of pancreatic islet cells, with particular reference to beta cells. I. Normal secretion in mice, rats, rabbits and chickens, and secretion stimulated by a single intravenous injection of glucose or chlorpropamide in rats.


Electron microscopic studies on the secretory mechanism of pancreatic islet cells, with particular reference to beta cells. II. Secretion of beta granules in islets of Langerhans, particularly in association with intracellular reactive zinc under normal conditions, during prolonged starvation, and after administration of dithizone in rabbits.


The mechanism of sleep disorders: some recent advances.


Personality: Dr. Auguste Tournay.

Personality: Dr. Auguste Tournay.


Agnes Karll.

Agnes Karll.


A method for measuring the motility of bacteria and for comparing random and non-random motility.


The cell wall of Escherichia coli: early effects of penicillin treatment and deprivation of diaminopimelic acid.


Electrophoretic separation of viral nucleic acids on polyacrylamide gels.


Studies on polynucleotides. 73. Synthesis in vitro of polypeptides containing repeating tetrapeptide sequences dependent upon DNA-like polymers containing repeating tetranucleotide sequences: direction of reading of messenger RNA.


Evidence for two sites for initiation of gene expression in the tryptophan operon of Salmonella typhimurium.


Studies on polynucleotides. LXXIV. Direct translation in vitro of single-stranded DNA-like polymers with repeating nucleotide sequences in the presence of neomycin B.


Effects of lambda-phage infection on bacterial synthesis.


Fractionation of nucleic acid on benzoylated-naphthoylated DEAE cellulose.


Immunological reactivity associated with antigens in the intestinal tract of rats.


Serum antibody responses to intestinal implantation of antigens in rats.


Spore morphology with special reference to the identity of the "O.S." variants of Clostridium botulinum type E.


Franz David Bielschowsky 5 January 1902-21 April 1965.


Michael John Ransford Dawkins 5 April 1931-27 June 1965.


Edgar Samuel John King 10 June 1900-31 January 1966.


Patient factors in appreciation of complete dentures.


Ridge extension technique combined with skin graft.


Zeiosis. I. Ejection of cell nuclei into zeiotic blebs.


Cordless tissue retraction for impressions for fixed prosthesis.


Active membranes for active transport.

Active membranes for active transport.


Cell membranes--composition: structure: function.


Mutation of bacterial cells by controlled desiccation.


The prasinomycins: antibiotics containing phosphorus.


Treatment of intestinal malabsorption.

Treatment of intestinal malabsorption.


Alexander Borodin, M.D. (1833-1887), physician, chemist, and composer.


Pneumocystis carinii pneumonitis. A review.


Quantitative aspects of blood coagulation in the generalized Shwartzman reaction. II. Effect of cortisone.


Physiological principles in the management of alimetary dysfunction.


Pyrimidine and purine bases and nucleosides in wheat plants.


Coliform behavior in frozen foods. I. Rapid test for the recovery of Escherichia coli from frozen foods. An assortment of 496 samples of frozen foods consisting of fish or marine products, variety types, and cream pie desserts were subjected to four parallel examinations for the recovery of Escherichia coli. The test procedures consisted of two low-temperature (35 C) and two high-temperature (44 C) presumptive tests, followed by an E C confirmatory test at 45.5 C. Of all the test methods examined, a single Lauryl Sulfate Tryptose (LST) presumptive test at 44 C gave best E. coli recovery (425). This recovery compared favorably with the lengthier Association of Official Analytical Chemists test with which only 420 E. coli cells were recovered. The LST (44 C) test saves much time, since it renders a follow-up 48-hr confirmatory test unnecessary. Moreover, since 96% of all the E. coli are recovered within 24 hr by LST (44 C), it is essentially a 24-hr test. The results of this study also confirmed earlier findings, in that it is possible to describe a specific coliform bacteriological test method by simple reproducible productivity ratios. E. coli recovery dilution data and coliform group behavior were also examined.


Thermal inactivation of type E botulinum toxin. The theoretical required cooking times for inactivation of type E Clostridium botulinum toxin (5,000 ld(50) mouse units per 0.5 ml) in haddock fillets of various sizes were calculated by graphical integration of the toxin inactivation rate and heat penetration data. The results indicated that normal cooking procedures should suffice to inactivate this amount of toxin. This conclusion was substantiated by the following additional experimental observations which revealed that the original experiments had been conducted under conservative conditions. First, maximal heat stability of the toxin was found to occur at about pH 5.5, with decreasing resistance upon increasing pH. The theoretical cooking times were based on destruction of the toxin at pH 6.7. The pH of radio-pasteurized inoculated haddock, when toxin production had occurred, was on the alkaline side, at which condition the toxin is heat-labile. Second, when spoilage was discernible in radio-pasteurized inoculated haddock, the toxin titer was low, about 50 ld(50) mouse units per 0.5 ml. Third, the toxin was adequately inactivated in toxic fillets after deep-fat frying for 3 min at 375 F (190.6 C) or after pan frying for 5 min per side at 400 F (204.4 C). Fourth, in this study, residual toxin activity was assayed by intraperitoneal injection of mice. It was shown that the oral toxic dose was 50 to 100 times greater than the intraperitoneal toxic dose.


Kinetics and mechanism of bacterial disinfection by chlorine dioxide. Survival data are presented for a fecal strain of Escherichia coli exposed to three concentrations of chlorine dioxide at four temperatures. Chick's first-order reaction equation is generalized to a pseudo nth-order model. Nonlinear least squares curve-fitting of the survival data to the nth order model was performed on an analogue computer. The data were observed to follow fractional order kinetics with respect to survival concentration, with an apparent activation energy of 12,000 cal/mole. Initial experiments support the thesis that the mechanism of chlorine dioxide kill occurs via disruption of protein synthesis.


Kinetics of the thermal inactivation of type E Clostridium botulinum toxin. Rate of inactivation curves for the "free" toxin, prototoxin, or activated toxin in crude filtrates of Clostridium botulinum type E were nonlinear, consisting of a fast inactivating rate followed by a slow inactivating rate. Thermodynamic parameters were calculated over a temperature range of 125 to 145 F (51.7 to 62.8 C) for the two different inactivation rates. Energy of activation was low at the lower temperature and high at the higher temperature. The thermal requirement for inactivating similar concentrations of the "free" toxin, prototoxin, or activated toxin was considered to be the same.


Soluble antigens for immunofluorescence detection of Histoplasma capsulatum antibodies. Soluble antigens from Histoplasma capsulatum in the mycelial and yeast phase were purified by gel filtration, fixed onto paper discs, and employed in an indirect immunofluorescence procedure to detect antibody in sera from individuals infected with H. capsulatum. The elution patterns of crude histoplasmin passed through Sephadex G-200 revealed two minor peaks of protein showing immunofluorescence, complement fixing, and precipitating-antigen activity. A large peak containing the pigment and other low molecular weight materials showed no serological activity. A polysaccharide antigen obtained from fragmented, deproteinized yeast-phase cells was reactive in the fluorescent-antibody test but showed no antigen activity in complement fixation or precipitin tests. Although certain sera from culturally proven cases of blastomycosis, coccidioidomycosis, and cryptococcosis reacted with the purified Histoplasma antigens, preliminary evaluation indicated that the immunofluorescence technique may be of value as a screening procedure for the serodiagnosis of histoplasmosis.


Some aspects of thermal injury in Escherichia coli. The effects of different temperatures on the viability of, and leakage of 260 mmu-absorbing substances from, a strain of Escherichia coli have been studied. Results of experiments with suspensions stored in water and in 0.33 m sucrose, together with total counts of suspensions before and after heating, suggested that the initial damage inflicted on the cell was to the permeability barrier. However, it was concluded that the evidence presently available for supporting this hypothesis is inadequate.


Examination of prepared foods in plastic packages for Clostridium botulinum. The incidence of Clostridium botulinum organisms was determined in a variety of plastic-packaged "vulnerable" foods (food requiring little or no heating prior to consumption). A total of 113 foods were examined by use of an enrichment recovery procedure followed by toxin testing in animals. Results of the survey indicate that the incidence of C. botulinum organisms in these vulnerable foods is extremely low. The ability of inoculated food products to support growth and toxigenesis of C. botulinum type E was then tested. The 64 packaged foods were inoculated with type E spores and incubated anaerobically at 30 C for 11 days. A slurry of each food was prepared, smears for fluorescent-antibody testing were made, and animal tests were performed for toxin. If the animal tests were negative, enrichment cultures were prepared from the slurry and incubated at 30 C. On direct examination of the slurries for toxin, only samples of turkey roll and soybean cake supported growth and toxigenesis by C. botulinum type E. However, the enrichment culture method was able to induce growth and toxin production in 60 of the remaining 62 samples.


Use of plastic spot-plates for in vitro assessment of antibacterials.


Large-scale production of tetanus toxoid.


The origin and sequence of the cells found in the acute inflammatory response.


Structure of the hepatic vascular system.


Microcirculation of islets of Langerhans in alloxan diabetes of mice.


Effects of dextran on human platelets.

Effects of dextran on human platelets.


Induced red cell aggregation and the transit time of red cells and plasma through the lung.


Microcirculatory aspects on the preservation of kidneys for transplantation.


Hemodilution and kidney function during shock.


Vasoactive substances and renal hemodynamics in man.


Effects of various anaesthetics on the metabolism and general condition of the isolated perfused rat liver.


R. G. Macfarlane, on his 60th birthday, June 26th 1967.


Chromosome micromanipulation. I. The mechanics of chromosome attachment to the spindle.


Loci for radiation sensitivity in Escherichia coli strain Bs-1.


The "individual" space.

The "individual" space.


The speed of action of desipramine: a controlled trial.


An unknown review by Freud.

An unknown review by Freud.


Sidney Tarachow; 1908-1965.

Sidney Tarachow; 1908-1965.


Leukocytes and hypersensitivity reactions. I. Eosinophil response in skin window to ragweed extract, histamine, and compound 48/80 in atopic and nonatopic individuals.


Children's cognitive style and response modification.


Effect of amygdaloid nuclear lesions on hypothalamic luteinizing hormone-releasing factor in the male deermouse.


Electrophoretic analysis of proteins from normal and cesium chloride-treated Escherichia coli ribosomes.


Role of the galactose transport system in the establishment of endogenous induction of the galactose operon in Escherichia coli.


Regulation of nucleoside triphosphate pools in Escherichia coli.


Properties of ribonucleic acid components in ribonucleoprotein particle preparations obtained from an Escherichia coli RC-relaxed strain.


Properties of ribonucleoprotein particles produced by an Escherichia coli RC-relaxed strain starved for histidine.


Message activity of RNA derived from immature ribosomes.


Attachment of ribosomes to nascent messenger RNA in Escherichia coli.


Characterization by in vitro complementation of a peptide corresponding to an operator-proximal segment of the beta-galactosidase structural gene of Escherichia coli.


Interaction of polyuridylic acid analogues with Escherichia coli ribosomes.


Plastic repair of the external urethral sphincter: a new technique for correction of postoperative incontinence in men.


The medical treatment of chronic peptic ulcer.


Witold Orlowski on his 92nd birthday and 70th anniversary of his scientific, didactic and socio-medical activity.


Significance of blood cultures in disseminated lupus erythematosus.


Pathomorphology of pancreas in experimental radiation sickness in rabbits.


Transplantation of skin and neoplasms as a test of genetic homogeneity of mouse strains.


Relationships between blood alcohol, positional alcohol nystagmus and postural equilibrium.


Tape-a-drama in treating alcoholics.

Tape-a-drama in treating alcoholics.


Treatment of alcoholism with lysergide. Comment on the article by Smart et al., with special reference to issues of responsibility in research reporting.


Treatment of alcoholism with lysergide. Comment on the article by Smart et al.


Evaluation of psychotherapy with alcoholics. A critical review.


Continuous hemostasis and continuous intravascular clotting: fact or myth?


Relation between formation and lysis of fibrin in the body.


The defibrination syndrome.

The defibrination syndrome.


Sleep and other behavioural responses induced by acetylcholinic stimulation of frontal and mesial cortex.


Patterns of response of animal tumors to anticancer agents. A systematic analysis of the literature in experimental cancer chemotherapy--1945-1958.


Spinal cord dysraphism in a dog.

Spinal cord dysraphism in a dog.


Studies of Rorschach content: a review of the research literature. 1. Traditional content categories.


Effect of test order upon children's Rorschach animal content.


The relation of TAT and inkblot aggressive content scales with each other and with criteria of overt aggressiveness in juvenile delinquents.


Stimulus factors in the relation between fantasy and behavior.


Visual differentiation, intersensory integration, and voluntary motor control.


The use of a sustained-release aspirin preparation in the management of rheumatoid arthritis and osteoarthritis.


Inhibitions, symptoms and anxiety: forty years later.


Binswanger and Freud.

Binswanger and Freud.


Giuseppe Levi (1872-1965).

Giuseppe Levi (1872-1965).


Aletamine in hospitalized schizophrenic patients--negative report.


Urinary bladder mucosa and bone regeneration in guinea-pig and rat.


In memoriam J. Franklin Robinson, M.D.--1910-1966.


Iron deficiency in women of fertile age in a Swedish community. I. Distribution of packed cell volume and the effect of iron supplementation.


Speech training or language acquisition? A distinction when speech training is taught by operant conditioning procedures.


Total obliteration of the esophagus due to lye burn restored by pharyngo-cutaneo-ceco-colo-gastrostomy. A contribution to the technique.


Study on the formation and release of insulin with special reference to electron microscopic observation.


The question of psychophysiologic infertility: some negative answers. A postscript.


The fine structure of the D-cells of the pancreatic islets in the domestic fowl and their morphological evidence of secretion.


Modified receptacle method for animal analgesimetry.


A possible explanation of chloramphenicol death in irradiated Escherichia coli b/r.


Modification of the effect of carotid artery occlusion by various agents.


The specific association of ribooligonucleotides of known chain length with denatured DNA.


Acceptor for thiomethyl galactoside in Escherichia coli k 12.


Inability of sRNA derived from peptidyl sRNA to accept amino acids.


Tryptophan as an inhibitor of 3-deoxy-arabino-heptulosonate 7-phosphate synthetase.


Circular dichroism of L-glutamic acid decarboxylase.


Further notes on cell refractometry using phase contrast microscopy.


The inactivation of pepsin by an equimolar amount of 1-diazo-4-phenylbutanone-2.


The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. 1. Gels were prepared with recrystallized acrylamide and bisacrylamide. Electrophoresis was in tris-sodium acetate-EDTA buffer for 0.5 to 3hr. Gels were scanned at 280 or 265mmu. Techniques are described for slicing and radioactive counting. 2. The mobility of RNA was inversely related to the sedimentation coefficient and varied with gel concentration. Electrophoresis in 2.2-2.6% gels gives a fractionation similar to density-gradient centrifugation. It shows the two ribosomal RNA components, the 45s precursor, transfer RNA and minor components. In 5% and 7.5% gels, 4s and 5s RNA separated and ribosomal RNA was excluded. 3. The resolution is greater and more detailed than by centrifugation, and many samples can be analysed simultaneously and rapidly.


Acylation of lysophosphoglycerides by Escherichia coli.


Purification and properties of l-valyl-sRNA synthetase from Escherichia coli.


Specific reaction of dansyl chloride with one lysine residue in rennin.


Changes induced by penicillin in the time course of intra- and extracellular fatty acid spectra of Escherichia coli 26-26.


Revival of heat-damaged Escherichia coli.


Beta-pyrrolo-L-alanine, a new antimetabolite of phenylalanine and tyrosine in Escherichia coli.


Synthesis of beta-galactosidase in Escherichia coli in the presence of phenylalanine analogues.


Immunochemical studies of the tryptic, chymotryptic and peptic peptides of heat denatured bovine serum albumin.


Effect of ethionine on the synthesis of beta-galactosidase in Escherichia coli.


Obituary notice E.G.D. Murray, 1890-1964.


Effect of food intake on growth and survival of salmonellas and Escherichia coli in the bovine rumen.


Studies on the effects of aerosolization on the rates of efflux of ions from populations of Escherichia coli strain B.


Antibody-carrying cells in the immune response 1. Identification of "rosette"-forming cells by light microscopy.


Cadaveric renal transplantation in man: first report from Israel.


Antikidney antibodies.

Antikidney antibodies.


Chronic pyelonephritis.

Chronic pyelonephritis.


Function of a transplanted kidney.

Function of a transplanted kidney.


Nutrition balance techniques and their limitations. Some aspects of the interpretation of mineral balances.


Absorption of nutrients from the intestine. Absorption of proteins.


The inhibition and mechanism of intestinal absorption.


Absorption of nutrients from the intestine. Recent studies on carbohydrate absorption.


Absorption of vitamin B12 from the intestine.


Sodium chloride absorption by the small intestine and the relationships between salt transport and the absorption of water and some organic molecules.


Absorption of nutrients from the intestine. Assessment of absorptive capacity.


Absorption of nutrients from the intestine. Iron absorption.


Some aspects of the absorption and concentration of iodide by the alimentary tract in man.


The absorption of calcium from the intestine.


Study of a new drug (oxazepam) in a large psychiatric institution.


Maxwell Gitelson: analytic aphorisms.

Maxwell Gitelson: analytic aphorisms.


Clinical observations on reserpine reversal after prolonged MAO inhibition.


House dust extract activity and volume effect.


Changing concepts of the growth process.


William Caldwell Young.

William Caldwell Young.


Control of fertility in mammals by hormonal steroids.


Mycotic infections of interest to thoracic surgeons.


Extended survival of the normothermic anoxic heart with metabolic inhibitors.


The electroretinogram (ERG): a review.

The electroretinogram (ERG): a review.


A trial of intravenous micoren, a respiratory stimulant, in respiratory failure.


An impairment of antibody production in adoptively restored, lethally irradiated thymectomized mice.


Lichen ruber bullosus and tumours in internal organs.


Resolution of melanin granules and epidermal cell types by ultraviolet television microscopy and by high-contrast phase microscopy of electron microscopic sections.


A clinical and immunological study of adrenocortical insufficiency (Addison's disease).


Extended storage of microbial cultures and culturing anaerobic bacteria with plastic pouches.


Nutritional health in the adolescent period.


Sir John M'Fadyean (1853-1941).

Sir John M'Fadyean (1853-1941).


Role of the intestinal contents in the pathophysiology of acute intestinal ischemia.


Diabetes mellitus. Lectures held in Cairo and Alexandria, January 1966.


Dimethyl sulfoxide (DMSO). Toxicology, pharmacology, and clinical experience.


The present status of simple mastectomy and radiation therapy in the treatment of carcinoma of the breast.


Staged reconstruction after en bloc resection for tumors of the tongue, floor of the mouth, and gum.


Our surgical heritage.

Our surgical heritage.


Our surgical heritage. Europe.

Our surgical heritage. Europe.


Phrenoesophageal-cardia-crural fixation in hiatus hernia repair.


A high incidence of cells with a condensed (telophase) chromatin pattern in human tumors and carcinoma-in-situ.


Comparative study of lymph node cytology by puncture and histopathology.


What is objective tumor response?

What is objective tumor response?


Chromosome analysis of solid tumors. I. Twenty-eight nonepithelial tumors.


Differences in trait attribution by patient and "normal" groups to line drawings of human facial pictures.


The relationship of reading improvement to scores on the Holtzman inkblot technique.


Body image in tattooed prisoners.

Body image in tattooed prisoners.


Relationships between the Goodenough DAM and Stanford-Binet in Negro and white public school children.


Expected and exceptional items on human figure drawings and IQ scores of children age 5 to 12.


Bibliography on Medical Education. Citations obtained through the National Library of Medicine's MEDLARS Program.


Imported falciparum malaria with inadequate response to chloroquine.


Dental internships at Martinez Veterans Administration Hospital.


1967 roster of the Greater St. Louis Dental Society.


The P-W Rotary Surveyor.

The P-W Rotary Surveyor.


Emerging problems and programs in health care.


Anatomical and physiological relations of a complete mandibular denture periphery.


Fundamentals in maxillary denture impressions.


Shortage of dentists by 1975?

Shortage of dentists by 1975?


Accredited Florida laboratories.

Accredited Florida laboratories.


Coverage of dentists' services under Medicare.


Occlusal adjustment with waxes et cetera.


A short history of blood transfusion.

A short history of blood transfusion.


Roster of members Kansas State Dental Association as of July 1, 1967.


Human pulpal response to new drugs and restorative materials.


The adjustable clasps.

The adjustable clasps.


San Antonio District Dental Society--1967 membership.


Interstitial emphysema--a clinical rarity?


Medicare and you.

Medicare and you.


Special committee on Medicare and Medicaid.


Recent federal health legislation--their impact on dentistry.


Designing an intracoronally retained partial denture.


Unconditioned and conditioned aggression and its relation to pain.


Comparison of recent experimental trends concerning sleep learning in the U. S. A. and the Soviet Union.


Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine.


Studies on the active site of the enzyme ribulosediphosphate carboxylase.


A kinetic study of the mechanism of action of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in Escherichia coli K 12.


The leukemias--proliferative or accumulative?


The timing of the various operations required for complete alveolar clefts and their influence on facial growth.


The effect of low molecular weight dextran on the micro-circulation of skin.


Modern mammaplasty.

Modern mammaplasty.


The application of the two-centimetre pedicle flap in plastic surgery.


Surgical treatment of malignant diseases of the peri-orbital area.


Extensive skin necrosis following anticoagulant therapy.


Autoimmunity in chronic bullous skin diseases. Immunofluorescent demonstration of three types of antibodies to skin in sera of patients with pemphigus, bullous pemphigoid and in other human sera.


The effects of air contamination on health. I.


Pressure and flow waves in systemic arteries and the anatomical design of the arterial system.


On-line correction of indicator-dilution curves.


lingua villosa nigra--a review of black hairy tongue.


Recovery through images of briefly flashed stimuli.


Effects of meprobamate on moods, emotions, and motivations.


Edmund James Cairns Molesworth.

Edmund James Cairns Molesworth.


Electromagnetic blood flowmetry in clinical surgery.


Extracorporeal preservation of canine kidney with subsequent reimplantation and contralateral nephrectomy.


The solitary bone cyst. A follow-up study of 24 cases.


Constantin Choremis.

Constantin Choremis.


Trophoblastic and subtrophoblastic mineral salt deposition in hydramnios.


Antinuclear factors in sera from chronic false positive seroreactors for syphilis.


Antinuclear factors in psoriatic arthritis.


Some observations on antagonism between penicillin and antineoplastic antibiotics.


Influence of resistance-factors on the phage types of Salmonella panama.


An assessment of the inhibitory activity of rat serum on staphylococci.


Liquid nitrogen for preservation and transportation of faecal samples.


Culture aeration in a polythermostat.

Culture aeration in a polythermostat. A system for the aeration of cultures growing in a polythermostat temperature-gradient block was developed. This system provided both aeration and agitation of the cultures, while allowing the growth to be followed spectrophotometrically. The necessity for aeration of cultures growing in a polythermostat was experimentally shown.


Floc sizing techniques.

Floc sizing techniques. In the study of mass transfer of substrate through floc particles, it is essential to have an estimate of floc size. This study presents floc size measurements made on pure culture bacterial floc and shows their applicability to mass transfer studies. A critical review of the biological literature on methods to size biological floc and determine wet floc density is also presented.


Radiation sterilization of prototype military foods. II. Cured ham. Ten lots of diced cured ham, packed in cans, were inoculated with approximately 10(6)Clostridium botulinum spores per can. Each lot was seeded with a different strain (five type A and five type B strains). All cans were irradiated to various dose levels with Co(60). Evidence provided by swelling, toxicity, and recoverable C. botulinum with 6,350 cans demonstrated that: (i) 4.5 Mrad was more than adequate as a sterilization dose; (ii) the minimal experimental sterilizing dose (ESD) based on nonswollen nontoxic endpoints was 2.0 < ESD </= 2.5 Mrad, and based on non-spoiled sterile cans was 3.0 < ESD </= 3.5 Mrad (the latter was supported by the computed theoretical 12D dose); (iii) D values calculated from botulinal survival data indicated that, as a group, the type A strains were more radioresistant than type B strains; strains 12885A and 41B, with respective D values of 0.242 and 0.175, represented the most resistant of each type; (iv) swollen cans did not always contain toxin, nor were toxic cans always swollen; (v) viable C. botulinum can exist for 6 months at 30 C without producing visible or toxic spoilage at doses of 3.0 Mrad and lower, including, in some instances, 0.0 Mrad; and (vi) a phenomenon similar to heat activation of spores occurred at sublethal radiation doses.


Influence of culture media on the radiation resistance of Micrococcus radiodurans. The addition of NZ-case (a tryptic digest of casein) to a growth medium (PC) consisting of tryptone, glucose, and yeast extract caused a significant decrease in gamma radiation resistance of Micrococcus radiodurans. The level of radiation resistance was inversely related to the concentration of NZ-case. The ld(50) for this organism was approximately 700 krad when grown in tryptone, glucose, yeast extract, and dl-methionine (TGYM) broth, but it was approximately one-half as resistant when grown in a PC medium containing 0.5% NZ-case (PCNZ). The resistance to ultraviolet light was also reduced. Cultures transferred from PCNZ to TGYM media regained the high level of resistance.


Gravity flow system for continuous culture feed.


Bacteriological survey of the frozen prepared foods industry. II. Frozen breaded raw shrimp. During inspection of 21 frozen breaded raw shrimp processors, 861 finished product units (retail packages) and 778 line samples were collected and analyzed bacteriologically. The bacteriological results for the finished product samples collected in plants with poor and good sanitary controls are presented and compared. The samples consisted of 4 to 38 units (retail packages) of the finished product as offered for sale by the processors. Frozen raw breaded shrimp collected from plants operating under good conditions of sanitation had the following bacterial contents: 85% of the samples had an average (geometric) aerobic plate count of less than 1,000,000 per gram; all of the samples had an average (geometric) most probable number of less than 1,000 coliforms per g; 81% of the samples contained less than 20% Escherichia coli-positive units; 57% of the total number of units in 0.1-g portions were negative for coagulase-positive staphylococci, and 95% of the units had less than 1,000 coagulase-positive staphylococci per gram.


Some aspects of the toxicity of flavouring substances.


Influence of platen temperatures and relative humidity during storage on the survival of freeze-dried Salmonella typhimurium. Salmonella typhimurium survived freeze-drying at a platen temperature of 120 F (48.9 C) and also, though to a much lesser degree, at 160 F (82.6 C). The extent of the survival at these temperatures was dependent on the composition of the model system employed. The incidence of damage immediately after freeze-drying was greater for cells dried at the higher platen temperature and was influenced by the composition of the menstruum in which the cells were dried. In model systems having protein-dominant isotherms, survival during subsequent storage depended greatly on relative humidity, with recovery highest at relative humidities below those corresponding to moisture contents at which a monomolecular layer is formed. In menstrua having a higher sugar content, survival was best at low relative humidities corresponding to a very low equilibrium moisture content in the model system used. Damage during storage tended to be a function of the composition of the gels in which the organisms were freeze-dried, and also depended greatly on the presence of air and on the relative humidity. The maximal percentage of damage usually occurred at the low relative humidities as storage time increased.


A crystal violet agar for recognition of Streptococcus agalactiae from direct culture of milk.


Extraneuronal binding of catecholamines and 3,4-dihydroxyphenylalanine (dopa) in salivary glands.


Parental counselling and spina bifida.

Parental counselling and spina bifida.


Studies of human kidney and urine beta-glucuronidase: II. In vitro and in vivo factors influencing measurement.


Immunofluorescent technique to detect anti-penicillin antibody.


Biochemical differentiation of a bacterial cell.


Pseudoinversions in the chromosome of Escherichia coli K-12.


Ditto deletions in the cysC region of the Salmonella chromosome.


Developmental cycle of sporeformers: a cellular type of differentiation in bacteria.


Mapping of the d-serine deaminase region in Escherichia coli K-12.


Transduction studies on the role of a rec+ gene in the ultraviolet induction of prophage lambda.


The mitomycin antibiotics. Synthetic studies. XV. The preparation of a related indoloquinone.


Analysis of the 5'-terminal nucleotide sequences of ribonucleic acids 1. the 5'-termini of Excherichia coli ribosomal RNA.


Absortive lysogenization of bacteriophage lambda b2 and residual immunity of non-lysogenic segregants.


Temperature-sensitive regulation system of prophage lambda induction.


Effect of ultraviolet irradiation on bacteriophage lambda immunity.


The problem of histocompatibility in wild hamsters.


Inhibition of growth of rII mutants of bacteriophage T4 by immunity substance of bacteriophage lambda.


A note on cross-cultural preferences: fruit-tree preferences in children's drawings.


Splenic arterial patterns angiographic analysis and review.


Sentio, ergo sum: "motivation" reconsidered.


Deans of medical schools. 3. Professor L. W. Cox.


Phosphorylation of pyridoxine by Escherichia coli B.


Experimental bone tumours caused by common viruses.


In memoriam of A. Zilber (1894-1966).

In memoriam of A. Zilber (1894-1966).


Essay on the problematics concerning the determination of benzpyrene in atmospheric air.


Effect of chlorine, antibiotics, beta-propiolactone, acids, and washing on Salmonella typhimurium on eviscerated fryer chickens.


Clinical evaluation of a new neuroleptic "thiothixene" (p-4657 b).


A transparent nonadhering silicone resin dish for embedding tissues in epoxy and polyester resins.


A microchamber for processing mammalian eggs.


Hypersensitivity to pituitary snuff with miliary shadowing in the lungs.


Aetiology and repair of tracheal stenosis following tracheostomy and intermittent positive pressure respiration.


Electron microscope studies of motile stages of malaria parasites. V. Exflagellation in Plasmodium, Hepatocystis and Leucocytozoon.


Cardiopulmonary effects of partial pulmonary arterial obstruction in dogs.


Experimental pyelonephritis. 13. On the ability of water diuresis to induce susceptibility to E. coli bacteriuria in the normal rat.


Fine structure of synapses in the dorsal nucleus of the lateral geniculate body of normal and blinded rats.


Enzymic formation of prodigiosin analog by a cell-free preparation from Serratia marcescens.


The simultaneous estimation of orthophosphate and carbamoyl phosphate and application to the aspartate transcarbamoylase reaction.


Stereotaxic localization of amygdaloid nuclei in rats from weaning to adulthood.


Benign mastopathies. Total gland excision with immediate reconstruction.


Ancient surgery of the Americas.

Ancient surgery of the Americas.


Intrathoracic neoplasms in Filipino children.


Controlled evaluations of repository therapy in ragweed hay fever.


Development and metapsychology of the defense organization of the ego.


Defense organization of the ego and psychoanalytic technique.


Gas-liquid chromatographic analysis of milk fatty acids: a review.


An improved microfluorimeter for measuring brightness of fluorescent antibody reactions.


Physical heterogeneity of the ribosomal proteins from Escherichia coli.


Amino acid substitutions resulting from suppression of nonsense mutations. 3. Tyrosine insertion by the Su-4 gene.


Isolation, purification and properties of 5 s ribosomal RNA: a new species of cellular RNA.


The catabolite repression gene of the lac operon in Escherichia coli.


The replication of bacteriophage MS2. VI. Interaction between bacteriophage RNA and cellular components in MS2-infected Escherichia coli.


The effect of intense visible light on cellular respiration.


Motor responses of the urinary bladder and skeletal muscle in botulinum intoxicated rats. 1. Type A or type D botulinum toxin administered to rats did not produce a generalized paralysis of skeletal muscles at the time of ventilatory arrest. However, if survival was extended by artificial ventilation complete blockade of neuromuscular transmission developed 6.5 hr after 100 MLD of type D and 5 hr after 1000 MLD of type A toxin. The onset of paralysis of a muscle was shortened by repetitive stimulation of the motor nerves.2. There was no consistent blockade of parasympathetically innervated viscera in animals dying after type A toxin. Animals given type D toxin displayed mydriasis and urinary retention before death.3. Motor responses to electrical stimulation, of bladder preparations in vitro were more vulnerable to type D than to type A toxin. When somatic paralysis was complete in animals treated with type A or type D toxin the excised bladders produced pressure elevations 45 and 25%, respectively, of control preparations.4. During electrical stimulation of bladder preparations nearly paralysed by either toxin, the ACh release was significantly diminished from controls. In the rat bladder botulinum toxin specifically disrupted the liberation of mediator from post-ganglionic nerve endings.


Inhibitors of protein synthesis at the ribosome level. Studies on their site of action.


Synergistic action of antibodies: detection of circulating antileucocyte antibodies after skin transplantation.


Penicillium sclerotigenum: a new source of griseofulvin.


Narciclasine: an antimitotic substance from Narcissus bulbs.


Do certain colicines and phages share common receptors?


Bacteriocinogeny in strains of Providence and Proteins morganii.


Enzyme hydrolysis of 6-benzylamino-9B D-ribofuranosylpurine and 6-hexylamino-9B D-ribofuranosylpurine.


Effect of growth hormone on the isolated pancreatic islets of rat in vitro.


Glucose and RNA synthesis in mammalian islets of Langerhans.


Studies on resistance transfer factors. II. Transmissible resistance to eight antibacterial drugs in a strain of Escherichia coli.


Hyperbaric oxygen therapy.

Hyperbaric oxygen therapy.


The use of tail vertebrae in the treatment of non-union fracture in the dog.


Psychological correlates of the development of amenorrhea in a stress situation.


De Lange's Amsterdam dwarfism: case report and etiological considerations.


Personality and interest patterns in obese adolescent girls.


Phase microscopic studies of neural elements from rat superior cervical sympathetic ganglia maintained in long-term cultures.


A note on the "dark" cells of the exocrine pancreas.


Formation of succinyl phosphate by reaction of phosphorylated succinic thiokinase with succinate.


Specificity of serine transfer ribonucleic acids in the synthesis of hemoglobin.


A new method for preparing ribosomal ribonucleic acid.


The Grünthal-Störring case of amnesic syndrome.


Amitriptyline and perphenazine in depressive illness. A controlled trial.


Spinal pathway mediating reticulopetal volleys.


Immunofluorescence identification of Mycoplasma on agar by use of incident illumination. The fluorescent-antibody method has been employed for the rapid identification of Mycoplasma colonies growing on agar plates. The method was found to be effective for detection of mixtures of Mycoplasma serotypes growing on primary isolation plates. The technique also helped to define the presence of mycoplasmas which did not produce typical colonies. It was also possible to identify Mycoplasma colonies overgrown by bacterial or fungal contaminants. Conjugates directed against 10 distinct Mycoplasma serotypes have been successfully employed in this system. One of the serotypes is a human oral isolate which has not been previously characterized.


Drug resistance of enteric bacteria. 8. Chromosomal location of nontransferable R factor in Escherichia coli. The R(21)(TC) factor, obtained by transduction of the R(10)(TC.CM.SM.SA) factor with phage epsilon to group E Salmonella, is not transferable by the normal conjugal process. However, when R(21)(TC)(+) transductants are infected with the F(13) factor, the nontransferable R(21)(TC) factor acquires transmissibility by conjugation. R(21)(TC)(+) conjugants of Escherichia coli K-12, to which only the R(21)(TC) factor was transmitted by cell-to-cell contact from an F' R(+) donor, were still unable to transfer their R(21)(TC) factor by conjugation. In crosses between Hfr and F(-)E. coli K-12 strains containing R(21)(TC), the gene responsible for tetracycline resistance was located on the E. coli K-12 chromosome between lac and pro, near lac.


Ultraviolet-sensitive targets in the enzyme-synthesizing apparatus of Escherichia coli. Inhibition by ultraviolet light of beta-galactosidase and alkaline phosphatase synthesis was investigated in both ultraviolet (UV)-sensitive and UV-resistant (wild-type) Escherichia coli, with the objective of determining the sensitivity of various targets. Kinetics of enzyme formation by unmated bacteria and in mating systems, in which the donor provided the specific genetic material and the recipient the cytoplasm, permit the following conclusions regarding the sensitivity of various targets. Catabolite repression resulting from UV damage causes most of the inhibition of beta-galactosidase formation. When it is largely eliminated by a step-down in nutrition, the principal target in UV-sensitive bacteria appears to be the structural gene (lacZ(+)), but damage to the cytoplasm is also important. Transitory inhibition by inactivation of messenger ribonucleic acid is also observed. In wild-type bacteria, repair reduces the importance of lesions in deoxyribonucleic acid sufficiently that cytoplasmic damage appears to be at least as important. Repair occurs within 10 min, as shown by recovery of enzyme-synthesizing ability. Caffeine and proflavine prevent recovery. Newly mated bacteria respond to irradiation very differently than do unmated bacteria. The beta-galactosidase or alkaline phosphatase structural gene (lacZ(+) or phoP(+)) is much more inhibited after it is transferred than it is in unmated bacteria. This sensitivity seems to depend on a sensitive state of the injected material, rather than on a different physiological condition of the entire zygote. Irradiation of recipient uvr(+) bacteria much more strongly inhibited expression of injected genes than if the F(-) was uvr(s). Studies on mating systems are not very useful for learning about the function of unmated bacteria.


Drug resistance of enteric bacteria. IX. Distribution of R factors in gram-negative bacteria from clinical sources. Many isolates belonging to the Enterobacteriaceae were collected in 1965 from the inpatients at geographically scattered hospitals in Japan. Among 2,650 Shigella strains examined, 58.4% were found to be drug-resistant; 95.0% of these resistant strains were multiply resistant. Among 434 resistant strains examined, 81% carried R factors that were transferable by cell-to-cell contact. Of 160 isolates of other enteric bacteria, drug-resistant strains included 84.2% of the Escherichia coli, 93.0% of the Klebsiella, and 90.0% of the Proteus cultures. Among these resistant strains, 70.3% of the E. coli, 66.7% of the Klebsiella, and 52.0% of the Proteus were multiply resistant. Of these resistant strains, 84.0% of the E. coli, 88.0% of the Klebsiella, and 50.0% of the Proteus strains carried R factors. These results indicate that R factors are widespread among gram-negative bacteria of clinical significance.


Kinetics of lethal adsorption of colicin E-2 by Escherichia coli. The kinetics of lethal adsorption of colicin E2 by Escherichia coli C6 were studied by means of survivor plots. These were determined by a method which allowed rapid sampling of the reaction mixture and estimation of approximate confidence limits for the plotted data. The results were consistent with the predictions of a hypothetical model that assumed a single-hit mechanism of colicin action upon a bacterial population whose cells varied in their number of specific (lethal) receptors for colicin. The possibility of nonlethal adsorption is discussed.


Growth inhibition test for identification of Mycoplasma species utilizing dried antiserum-impregnated paper discs. The growth inhibition test for identifying Mycoplasma species has been modified by drying antibody-impregnated paper discs at 5 C. When stored at -20 C, these discs have been found to retain their inhibitory activity for longer than 7 months. Since these discs can be stored for long period of time, significant advantages over present methods result. When, for example, discs are arranged on a ring, a single test can be used for the identification of an unknown human species. Valuable antisera can be distributed to other laboratories on paper discs in much less volume than can fluid antiserum. Considerable savings of time result from prior preparation of many discs that can then be stored and used over a long period of time. The growth-inhibiting antibody is stable, and the activity is not enhanced by a heat-labile accessory factor from fresh guinea pig serum which increases the antibody titer in the metabolic inhibition test.


Glucose-lactose diauxie in Escherichia coli. Growth of Escherichia coli in medium containing glucose, at a concentration insufficient to support full growth, and containing lactose, is diauxic. A mutation in the gene, CR, which determines catabolite repression specific to the lac operon, was found to relieve glucose-lactose but not glucose-maltose diauxie. Furthermore, a high concentration of lactose was shown to overcome diauxie in a CR(+) strain. Studies on the induction of beta-galactosidase by lactose suggested that glucose inhibits induction by 10(-2)m lactose. Preinduction of the lac operon was found to overcome this effect. The ability of glucose to prevent expression of the lac operon by reducing the internal concentration of inducer as well as by catabolite repression is discussed.


Genetic analysis of glutamate transport and glutamate decarboxylase in Escherichia coli. The location of the Escherichia coli K-12 genes determining or regulating glutamate transport, and the location of the gene determining glutamate decarboxylase synthesis, were established by conjugation. The ability to grow on glutamate as the sole source of carbon and energy was used to select for glutamate transport recombinants. Two genes determining the ability to grow on glutamate as the sole source of carbon and energy were mapped. One (gltC) is located near mtl (mannitol), and the other (gltH) appears to be located between the gal (galactose) and trp (tryptophan) loci. The glutamate decarboxylase gene (gad) is strongly linked to gltC. The gltC(+) recombinants grow on glutamate much faster and accumulate this amino acid to a greater extent than do the gltH(+) recombinants. The gltH(+) gene functioned only in one female strain (P678), whereas the gltC gene functioned in all the female strains tested (P678, C600, W1).


Induction of L forms of Haemophilus influenzae in culture and their demonstration in human bronchial secretions. Transitional forms and round bodies of Haemophilus influenzae were identified in sputa from patients with chronic bronchitis who were receiving penicillin therapy for H. influenzae infections. In vitro growth of L forms of this organism was induced by penicillin and glycine and was studied for comparison with development in vivo. Variant forms demonstrated in sputum were similar to variant forms observed in penicillin-induced L colonies. Recurrence of infection after cessation of therapy was related to reversion of persisting L forms to bacillary forms. That these forms were derived from H. influenzae was established by direct staining with fluoresceinlabeled specific antibody. This demonstration that transitional forms and round bodies of H. influenzae occurred in vivo suggests that L forms of bacteria may be significant in chronic or recurrent infections.


Outgrowth and toxin production of nonproteolytic type B Clostridium botulinum at 3.3 to 5.6 C.


Use of exogenous deoxythymidylic acid to label the deoxyribonucleic acid of growing wild-type Escherichia coli.


Delta-aminolevulinic acid-requiring mutant from Escherichia coli.


Medium for differentiation of acid-producing colonies with homogeneously suspended calcium carbonate.


Current status of multi-isotope scanning by color modulation.


Double isotope dilution derivative assay of plasma testosterone.


Allograft survival following antibody suppression with radioiodine-labeled antigen.


Quantitation of the R.I.S.A. aerosol distribution in the normal human lung.


Coated charcoal assay of plasma iron binding capacity and iron using radioisotope dilution and hemoglobin-coated charcoal.


Clinical pharmacology--a review. Federal Drug Regulations and their impact on clinical pharmacology.


Dental aspects of the prenatal administration of fluoride.


Irreversible enzyme inhibitors. 88. Differential irreversible inhibition of dihydrofolic reductase from different species.


Tissue culture in the study of the effects of drugs.


Design of skin flaps to study vascular insufficiency.


Normothermic orthotopic canine heart homotransplantation.


Dynamic aspects of collagen biology. I. Synthesis and assembly.


Molecular models for the circadian clock. I. The chronon concept.


Packing of the DNA molecule.

Packing of the DNA molecule.


A simple one-stage procedure for urethral strictures.


Surgical correction of intrarenal disease. I. Obstructions of the superior infundibulum.


Drug treatment in depression. Antidepressant or tranquilizer?


Some serum protein and cellular constituents of inflammatory lesions. Collection of exudates in a chamber adhered over skin wounds of rabbits.


Streptobacillary rat-bite fever with massive pericardial effusion.


Recent advances in chemotherapy of lymphoma.


Relationship between serotonin and the circadian rhythm in some nocturnal moths.


Characterization of the time variations of reproductive processes in living cells.


Four transfer factors in a single bacterial strain.


Time course of action of diazepam.

Time course of action of diazepam.


A strong suppressor specific for UGA.

A strong suppressor specific for UGA.


Vaccinia virus antigen in the lymphoid system of white rats.


Technique for investigation of sex chromatin in amniotic membrane of rat foetuses.


Evidence for a non-plasma source of urea in sweat.


Reciprocal in toto conversion of  Mycobacterium phlei--Mycobacterium smegmatis by mediation of an intermediate hybrid genome: B2h.


Changes in neurosecretory activity at different stages in the adult Hyalomma dromedarii Koch, 1844.


Long-term experience with sulfonylureas and placebo.


Carcinoma of the breast. A decade of new results with old concepts.


Histocompatibility testing in the rabbit.


The fetal membranes as a barrier to transplantation immunity.


Histocompatibility genes of mice. VII. H-13, a new histocompatibility locus in the fifth linkage group.


The rate of growth and pattern of differentiation of transplanted frozen and thawed hematopoietic cells.


The mammary fat pad as a privileged transplantation site.


Passive enhancement of neonatal skin grafts.


AOA's president for 1967-1968.

AOA's president for 1967-1968.


Review of consultation psychiatry and psychosomatic medicine. II. Clinical aspects.


Nuclear pyknosis in neuroglia cells of normal mammals.


Historical and political roots of the Community Mental Health Centers Act.


Mucogingival surgery--utilization of interdental gingiva as attached gingiva by surgical displacement.


Variations in cognitive control and psychophysiological defense in the schizophrenias.


Serological and cultural studies of chicken breeding flocks and their progeny for Mycoplasma.


Transplantation.

Transplantation.


Fatty acid synthesis in Escherichia coli. 1. Fatty acid formation by cells of a strain of Escherichia coli has been studied in the exponential, post-exponential and stationary phases of growth. 2. During the exponential phase of growth, the metabolic quotient (mmumoles of fatty acid synthesized/mg. dry wt. of cells/hr.) for each fatty acid in the extractable lipid was constant. 3. The newly synthesized fatty acid mixtures produced during this phase contained hexadecanoic acid (41%), hexadecenoic acid (31%), octadecenoic acid (21%) and the C(17)-cyclopropane acid, methylenehexadecanoic acid (4%). 4. As the proportion of newly synthesized material increased, changes in the fatty acid composition of the cells during this period were towards this constant composition. 5. Abrupt changes in fatty acid synthesis occurred when exponential growth ceased. 6. In media in which glycerol, or SO(4) (2-) or Mg(2+), was growth-limiting there was a small accumulation of C(17)-cyclopropane acid in cells growing in the post-exponential phase of growth. 7. Where either NH(4) (+) or PO(4) (3-) was growth-limiting and there were adequate supplies of glycerol, Mg(2+) and SO(4) (2-), there was a marked accumulation of C(17)-cyclopropane acid and C(19)-cyclopropane acid appeared. 8. Under appropriate conditions the metabolic quotient for C(17)-cyclopropane acid increased up to sevenfold at the end of exponential growth. Simultaneously the metabolic quotients of the other acids fell. 9. A mixture of glycerol, Mg(2+) and SO(4) (2-) stimulated cyclopropane acid formation in resting cells.


Intracellular protein breakdown in growing cells of Escherichia coli. 1. When Escherichia coli was grown exponentially in a defined medium at 35 degrees , the rate of protein breakdown was initially rapid, but decreased to 0.6%/hr. after about 30min. The latter rate was maintained for at least 3.5hr. 2. The initial rapid rate may have been due to the presence of a small protein fraction (about 1%) that was degraded with a half-life of 13min. 3. The rate of protein degradation was the same during balanced growth at low rates imposed in a bactogen. However, it increased during the period immediately after a decrease of the growth rate.


Intracellular protein breakdown in non-growing cells of Escherichia coli. 1. When Escherichia coli leu(-) was incubated at 35 degrees in a medium based on minimal medium, but with the omission of phosphate ions, or glucose, or NH(4) (+) ions and leucine, intracellular protein was degraded at a rate of about 5%/hr. in each case. If Mg(2+) ions were omitted, however, the rate of degradation was 2.9%/hr. 2. Under certain conditions of incubation, protein degradation was inhibited. The inhibitor was neither NH(4) (+) ions nor amino acids, and its properties were not those of a protein, but it might be an unstable species of RNA. 3. Although a large part of the cell protein was degraded at about 5%/hr. during starvation of NH(4) (+) ions and leucine, some proteins were lost at more rapid rates, whereas others were lost at lower rates or not at all. 4. In particular, beta-galactosidase activity was lost at about 8%/hr. during starvation of NH(4) (+) ions and leucine, whereas d-serine-deaminase and alkaline-phosphatase activities were stable. During starvation of Mg(2+) ions, all three enzyme activities were stable.


Involvement of the lac regulatory genes in catabolite repression in Escherichia coli. 1. Acute transient catabolite repression of beta-galactosidase synthesis, observed when glucose is added to glycerol-grown cells of Escherichia coli (Moses & Prevost, 1966), requires the presence of a functional operator gene (o) in the lactose operon. Total deletion of the operator gene abolished acute transient repression, even in the presence of a functional regulator gene (i). 2. Regulator constitutives (i(-)) also show transient repression provided that the operator gene is functional. Regulator deletion mutants (i(del)), with which to test specifically the role of the i gene, have not so far been available. 3. The above mutants, showing various changes in the lactose operon, show no alteration in the effect of glucose on induced tryptophanase synthesis. Glucose metabolism, as measured in terms of the release of (14)CO(2) from [1-(14)C]glucose and [6-(14)C]glucose, also showed no differences between strains exhibiting or not exhibiting transient repression. This suggests no change in the operation of the pentose phosphate cycle, a metabolic activity known to be of paramount importance for glucose repression of beta-galactosidase synthesis (Prevost & Moses, 1967). 4. Chronic permanent repression by glucose of beta-galactosidase synthesis (less severe in degree than acute transient repression) persists in strains in which transient repression has been genetically abolished. Constitutive alkaline-phosphatase synthesis, which shows no transient repression, also demonstrates chronic permanent repression by glucose. 5. Chloramphenicol repression also persists in mutants with no transient repression, and also affects alkaline phosphatase. It is suggested that chronic permanent repression and chloramphenicol repression are non-specific, and that they do not influence beta-galactosidase synthesis via the regulatory system of the lactose operon.


Surgical techniques for eradicating far advanced carcinoma of the orbital-ethmoid and maxillary areas.


Nature, intracellular distribution and formation of terpenoid quinones in Euglena gracilis. 1. Light-grown cells of Euglena gracilis strain Z, var. bacillaris and 1224/5g contain phylloquinone, plastoquinone, alpha-tocopherol, alpha-tocopherolquinone and ubiquinone-9 (i.e. ubiquinone with 9 isoprene units/mol.). 2. The concentration (per g. dry wt.) of plastoquinone (and chlorophyll) in light-grown cells of strain Z was governed by the composition of the culture medium and age of the cells. Highest yields of plastoquinone were obtained under autotrophic conditions, the concentration reaching a maximum after 6-8 days' growth. The concentrations were less in heterotrophic media. The concentration of ubiquinone was relatively unaffected by the age of the cells or composition of the medium. 3. In light-grown cells of strain Z plastoquinone, alpha-tocopherolquinone and alpha-tocopherol were mainly localized in the chloroplast; ubiquinone was found to be in the mitochondria. 4. Etiolated (dark-grown) cells of strain Z contained no phylloquinone, plastoquinone or alpha-tocopherolquinone; alpha-tocopherol was present in lower concentrations compared with light-grown cells; ubiquinone concentrations were similar to those for light-grown cells. The presence of alpha-tocopherol in etiolated cells suggested that this chromanol was not entirely confined to the chloroplast. 5. On illumination of etiolated cells of strain Z the chloroplastidic components plastoquinone, alpha-tocopherolquinone and alpha-tocopherol were synthesized in step with chloroplast formation. Ubiquinone concentrations, as expected, were unaffected. 6. [2-(14)C]Mevalonic acid, the specific distal terpenoid precursor, was not incorporated into any of the terpenoid components examined. This was attributed to the impermeability of the cell wall to this compound, rather than to a novel pathway of terpenoid biosynthesis.


The primary structure of porcine pancreatic elastase. The N-terminus and disulphide bridges. 1. The amino acid composition and N-terminal groups of purified elastase show that it is a single peptide chain of 234 residues. 2. The N-terminal sequence is Val-Val-Gly-Gly-Thr-Glu-. 3. The sequences around the four disulphide bridges were determined by using a ;diagonal' electrophoretic technique. 4. These four bridges are homologous with the four common to bovine trypsin and chymotrypsin. 5. Out of 83 residues of the elastase sequence so far determined, 43 are homologous with similar regions of trypsin and chymotrypsin. 6. The evolutionary ancestry of these enzymes is discussed.


Psychological theories of E.C.T.: a review.


The relation of chemical carcinogens to steroid metabolism.


The edentulous patient who hand an Angle's Class II division II occlusion on a normal skeletal base.


Short notes on electrolytic or anodic brightening.


Papers published by Prof. Dr. J.R. Prakken.


Prof. Dr. J.R. Prakken on his 70th birthday.


Expanding concepts in the microbiological examination of foods.


Cooperative microbial surveys of surfaces in hospital patient rooms.


Members of the Colorado Dental Association, June 1967.


Survival of coagulase-positive staphylococci in soluble cutting oils.


Freeze-drying of small tissue samples and thin frozen sections below -60 degrees C. A simple method of cryosorption pumping.


A method for pontic stabilization in fixed partial denture construction.


Potentiation of the teratogenic effect of vitamin A with exposure to low environmental temperature.


Anatomicopathological aspects of tumors of the digestive tract in the French-speaking people of Western Africa.


Cancer of the alimentary tract in Egyptians.


Macroscopic and microscopic study of a mandible with a 12-year implant denture in place.


A short copper ring technique for jacket and post-crown impressions.


Congenital choanal atresia.

Congenital choanal atresia.


Conditional reflex studies in mental retardation: a review.


Evaluation of the forward triangle factor in the newborn infant.


Transmitter histochemistry of the sympathetic adrenergic nervous system.


Pigment cell migration in piebald mice.

Pigment cell migration in piebald mice.


Chlordiazepoxide in the treatment of patients with "activated EEG's".


Medial forebrain bundle lesions: blockade of effects of light on rat gonads and pineal.


Imipramine and thioridazine: lack of peripheral effects.


Congenital malformations of the cerebrospinal axis seen in Western Nigeria. The spinal meningoceles.


The treatment of adenosis (adenomatosis) vaginae.


A clinical trial and cytological assessment of enol LUTEOVIS IN THE TREATMENT OF THREATENED AND RECURRENT ABORTION.


Fluorescent antibodies in genital candidiasis.


The bacterial content of the female urethra in pregnancy.


A case of intestinal and urogenital duplication.


The effect on an intra-uterine suture on fertility in the rat.


Prevention of dental caries. I. Phosphates and dental caries.


The acute action of urea on ventilatory function in patients with asthma.


The greatest of scientific non-organizations.


Editorial: civil rights and the clinical investigator.


Immunological tolerance in the absence of cellular chimerism.


A re-evaluation of the role of the autonomic nervous system upon renal function from the view of a pharmacologist.


The relevance of modern clinical trial methodology to the practice of medicine.


Professor R. M. Sievert.

Professor R. M. Sievert.


Report on a case of reconstruction of the penis.


Pathogenic organisms in the sputum of patients with chronic bronchitis.


The new president of the R.C.V.S.

The new president of the R.C.V.S.


The protection of calves against infection with Salmonella typhimurium by means of a vaccine prepared from Salmonella dublin (strain 51).


Effects of progesterone and pentobarbitone on hypothalamic induction of ovulation in the 5-day cyclic rat.


Reconstruction of the human atrioventricular node.


A clinical and histochemical study of disorders of the human testes.


Induced genital anomalies.

Induced genital anomalies.


Deuterium isotope effects on beta-galactosidase formation by Escherichia coli.


Catabolite repression and the Pasteur effect in Escherichia coli.


Phosphorescence of soluble RNA.

Phosphorescence of soluble RNA.


Fractionation of the acid-soluble nitrogen of bone and dentine.


Regulation of phosphoenolpyruvate carboxylase activity in Escherichia coli.


The effect of nutritional state on lipoprotein lipase activity in isolated rat adipose tissue cells.


A pyrimidine-specific carbamate kinase in Neurospora.


Personal relevance and the choice of constructs for the repertory grid technique.


The anaesthetist looks at tissue transplantation: three years' experience with kidney transplants.


Canadian Anaesthetists' Society medal (Georges Cousineau).


Effect of cobalt ions on myocardial metabolism.


Reductive dechlorination of DDT by Escherichia coli.


Observations on selected isolated retinal elements and an analysis of rod cell RNA of the rabbit. RNA was analyzed in the whole rod cell and in the rod cell nucleus of the rabbit retina. The analysis was performed on rod cells or rod cell nuclei after they were isolated by microdissection and collected. The nuclei were denuded by selectively lysing inner and outer segments chemically. The rod cell contained an average of 0.65 micromicrog RNA. About 60% of the total RNA was nuclear. RNA concentration was of the order of 0.4% w/v. RNA base composition was determined for the whole rod cell and for the rod cell nucleus, and from it the base composition of cytoplasmic RNA was derived also. Microdissection of the retina revealed that each Müller cell had firmly attached to it a certain complement of visual cells, forming a bouquet-like arrangement. The unusual susceptibility of the inner and outer segments to lysis was regarded as an indication of an unique composition of the plasma membrane.


A note on preparing new stimuli for in-line readout projectors.


The subcellular origin of bioluminescence in Noctiluca miliaris. The light emitted by Noctiluca has its origin in 1 to 5 x 10(4) organelles ("microsources") which are scattered throughout the perivacuolar cytoplasm, and which appear to be the elementary functional units of bioluminescence. Microscopical techniques, image intensification, and microphotometry were employed in their investigation. Microsources are fluorescent, strongly phase-retarding, and range widely in diameter below 1.5 microns. The number of quanta emitted in a flash from a microsource ("microflash") is of the order of 10(5) photons. However, microflashes show a wide range of intensities, which are correlated with the size of the organelles from which they arise. Each organelle responds repetitively and with reproducible time course to a succession of invading triggering potentials. Reversible changes in the intensity of the flash emitted by the whole cell ("macroflash") occur because of graduations in intensity of microflashes rather than as a result of changes in the number of responsive organelles. The shape of the flash emitted by individual microsources resembles that of the macroflash except for slightly shorter rise and decay times. It is concluded that the macroflash results from somewhat asynchronous, but otherwise parallel summation of microflashes.


A mutant which reinitiates the polypeptide chain after chain termination.


Ribosome-bound messenger RNA in T4-infected bacteria.


Control of production of ribosomal protein.


Hemoglobins of mice: sequence and possible ambiguity at one position of the alpha chain.


Kinking of the medulla in children with acute cerebral oedema and hydrocephalus and its relationship to the dentate ligaments.


Foreword to investment in the future.

Foreword to investment in the future.


Investment in the future.

Investment in the future.


An impression procedure for construction of maxillary immediate dentures.


Converting a tooth-supported denture to a distal-extension-removable partial denture.


Castings made directly to refractory dies.


Sigmund freud and the art of letter writing.


When the scalpel sharpens the pen.

When the scalpel sharpens the pen.


Patriotic gore. Introduction to Civil War books by physicians.


The changing image of the American physician.


Some little-known classics of old-age medicine.


Experimental studies on sleep produced by methaqualone.


The use of alginate impression materials for making indirect one-piece castings.


Multiple cysts of the jaw, basal cell carcinomas and bifid ribs.


Medical bibliography and MEDLARS.

Medical bibliography and MEDLARS.


Early homografting of second degree burns.


The experimental demonstration in man of a dissociation between immune mechanisms mediating delayed hypersensitivity and homograft rejection.


Surgical treatment of the receding hairline.


A local flap for repair of the nasal tip.


Plastic surgery in the treatment of cutaneous leishmaniasis of the face.


Use of the mesh skin graft in treatment of massive casuality wounds.


The use of a volar flap for repair of fingertip amputations: a preliminary report.


Biologic excision: its value in the treatment of radionecrotic lesions.


Hydroxyethyl methacrylate combined with polyethylene glycol 400 and water; and embedding medium for routine 1-2 micron sectioning.


Punched-out agar Petri plates for systematic fixation and embedding of multiple small tissue samples.


Orientation of flat specimens for ultrathin sectioning across their edges by embedding in slotted matrices; a one-stage procedure.


Survey for blastomycosis and histoplasmosis among stray dogs in Arkansas.


Indirect fluorescent antibody technique for diagnosis of canine filariasis.


Degradation of ribosomal RNA in a temperature-sensitive Escherichia coli.


Proteins and catalase isoenzymes from Fusarium solani and their taxonomic significance.


Characterization of 3-deoxy-D-manno-octulosonic acid as a component of the cell wall lipoglycan from Escherichia coli (2101-R).


Effect of some myotropic substances on mollusc hearts.


Subunits of the complex protein carrying the threonine-sensitive aspartokinase activity in a mutant of Escherichia coli K 12.


Structure of streptococcal cell walls. V. Phosphate esters in the walls of group A Streptococcus pyogenes.


The reactivity of haemoproteins and cytochromes.


The effect of soluble ribonucleic acid on the binding of rapidly 14C labelled ribonucleic acid to ribosomes.


An extracellular lipopolysaccharide-phospholipid-protein complex produced by Escherichia coli grown under lysine-limiting conditions. Lysine limitation during growth of the lysine-requiring mutant of Escherichia coli 12408 resulted in the excretion of a complex containing 60% of lipopolysaccharide, 26% of extractable phospholipid and 11% of protein. The complex was obtained from the culture filtrate in yields of about 0.5g./l. by precipitation with chloroform or gel filtration; some purification steps are described. The greater part of the phospholipid consisted of phosphatidylethanolamine, which contained four main fatty acids; two monoenoic acids and a cyclopropane acid were esterified mainly in the beta-position, and a saturated acid was located mainly in the gamma-position. The protein component was relatively insoluble and contained an excess of acidic over basic amino acids and little cystine. The lipopolysaccharide resembled in composition the intracellular lipopolysaccharides from rough strains of E. coli. Both protein and lipopolysaccharide constituents of the complex were serologically active; the complex was less toxic than the purified lipopolysaccharide. In the electron microscope the complex showed a mixture of particles of various sizes and shapes. Rods and hollow spheroids (diameter 12-200mmu) were most common and resembled the particles previously found surrounding cells actively excreting the complex. The chloroform-precipitated material showed a tubular lamellar structure. Soluble lipopolysaccharide prepared from the complex also consisted of hollow spheres and rods.


The stereotaxic obliteration of intracranial aneurysms.


Percutaneous trigeminal tractotomy. Case report-utilizing stereotactic radiofrequency lesion.


Effect of various plant phenols on protein synthesis in excised plant tissues.


Cellular polysaccharides of Serratia marcescens.


1-Aminocyclopentanecarboxylic acid, an inhibitory analogue of methionine in Escherichia coli.


Constituents of the roots of Bryonia dioica Jacq.


License to practice medicine and surgery.


The barrier variable as measured by homonyms.


SORT relationships of anxiety and awareness for alcoholics, neurotics and psychotics.


Pinckney Jones Harman (1913-1966).

Pinckney Jones Harman (1913-1966).


Lactation inhibition with quinestrol.

Lactation inhibition with quinestrol.


Poisonous marine animals, a synopsis.

Poisonous marine animals, a synopsis.


The transmissible nature of the genetic factor in Escherichia coli that controls haemolysin production.


Double blind intensive safety and tolerance studies during quinestrol therapy in elderly women.


A new principle for the determination of total bacterial numbers in populations recovered from aerosols.


The continuous culture of anaerobic bacteria.


Response of human vaginal epithelium to single high dose or daily lower dose of oral quinesteol.


The nature of man or man's place in nature? Bruno, Spinoza, and la Mettrie.


Interstrand cross-linking of DNA by difunctional alkylating agents.


Characterization of the particulate and free proteins obtained after treatment of ribosomes with 2 M-lithium chloride.


A mutation suppressing streptomycin dependence. I. An effect on ribosome function.


Studies on polynucleotides. LXVII. Initiation of protein synthesis in vitro as studied by using ribopolynucleotides with repeating nucleotide sequences as messengers.


Ion-binding studies of ribonucleic acid and Escherichia coli ribosomes.


Double blind placebo controlled efficacy and safety study with quinestrol.


Lumbosacral lipomas: critical survey of 26 cases submitted to laminectomy.


Magnetic probe for the stereotactic thrombosis of intracranial aneurysms.