Exercise tolerance of cold-acclimated rats. Serum and liver enzymes and histological changes.


The cholinesterase-inhibitory characteristics of Parpanit and its analogues in relation to their protective effectiveness in the treatment of sarin-poisoned rodents.


Serotonin and other vasoactive agents in experimental decompression sickness.


Comparative effect of procainamide and lidocaine on myocardial contractility.


Removal of endogenous and exogenous toxins by a microencapsulated absorbent.


Prevention of indomethacin-induced intestinal ulcers by spironolactone and norbolethone.


The effect of cortisone on brown adipose tissue of young rats.


Turnover rates of D-isoascorbic acid and L-ascorbic acid in guinea pig organs.


Site of action of endotoxin in evoking bradycardia.


Sex education and the public health nurse.


The effect of lignocaine on the stimulation threshold and conduction disturbances in patients treated with pacemaker.


Electrocardiographic studies in the rat in physiological and pathological states.


Electrocardiographic changes and tissue catecholamines in experimental subarachnoid haemorrhage.


Acute coronary occlusion in pigs: effects of acetyl strophanthidin.


Measurement of forearm blood flow during venous congestion by withdrawal of venous blood.


Contractility and tension development of the myopathic hamster (Bio 14-6) heart.


The effect of hypertonic saline on pulmonary circulation.


Intramural pressure in the left ventricle of the dog.


Pulmonary mast cells in mitral stenosis.


An improved technique for measuring changes in myocardial perfusion by the nitrous oxide method.


The evaluation of an ultrasonic flow detector for the assessment of peripheral vascular disease.


A modified axial lead system for orthogonal lead electrocardiography.


Neonatal startles, smiles, erections, and reflex sucks as related to state, sex, and individuality.


Children's conceptions of events before and after confession of transgression.


The young child's ability to imitate and comprehend speech: a comparison of two subcultural groups.


A novelty interpretation of the Moss-Harlow effect in preschool children.


Children's aggression following competition and exposure to an aggressive model.


The development of the use of sound as a guide to affective and cognitive behavior--a two-phase process.


On the meaning of behavior: illustrations from the infant.


The relation between laboratory measures of sucking, food intake, and perinatal factors during the newborn period.


Pattern variability and numerosity as determinants of individual preferences in children and adults.


Changes in equivalence judgments following verbal, perceptual, or functional practice conditions.


Reflective and impulsive observing behavior.


Identification of absolute and relational properties in the three-stimulus (ABB) configuration.


The relationship between race and perception of racially related stimuli in preschool children.


The relationship of birth order and socioeconomic status to the creativity of preschool children.


Object relations, dependency, and attachment: a theoretical review of the infant-mother relationship.


A semi automated method for plasma arginase.


Familial distributions of organ specific antibodies in the blood of patients with Addison's disease and hypoparathyroidism and their relatives.


Immune responses in aged mice.

Immune responses in aged mice.


Treatment of Kaposi's sarcoma.

Treatment of Kaposi's sarcoma.


A new test for cholinesterase (ChE) prior to electro shock therapy.


Brain lipid analysis of a myelin deficient mutant, the "quaking" mouse.


Localization and function of external and internal carnitine acetyltransferases in mitochondria of rat liver and pig kidney.


Biosynthesis of Salmonella lipopolysaccharide. The in vitro transfer of phosphate to the heptose moiety of the core.


A comparative study of histone fractions F2(a)1 and F2(a)2.


Effect of ATP on the oxidation of succinate in rat brain mitochondria.


Metabolic regulation of polygalacturonic acid trans-eliminase in Erwinia.


Isolation of an ionic strength dependent cell agglutinin from bovine seminal plasma.


The cytoplasmic DNAs of cultured human cells.


Alpha-chymotrypsin-catalyzed hydrolysis of N-furylacryloyl-tyrosine derivatives.


Fasting bile salt pool size and composition after ileal resection.


A rational program for the management of hepatic coma.


15-Hydroxy-prostanoate dehydrogenase. Prostaglandins as substrates and inhibitors. Determination of Michaelis constnats and maximum reaction rates for a series of prostaglandin dehydrogenase substrates showed that the enzyme is stereospecific with regard to configuration at C-15.  Substituents of the cyclopentane ring did not markedly affect the properties as a substrate, whereas the nature of the carboxyl side chain proved important.  A noncompetitive inhibition was produced between prostaglandin B compounds and a synthetic epimer of prostaglandin E1, 15-R-prostaglandin E1.


Pathogenesis of cholera.

Pathogenesis of cholera.


Factors concerned in the pathenogenesis of gallstones.


Health patterns of aged migrant retirees.


The geriatric patient from a psychiatric standpoint.


Corrective therapy maintenance program in geriatric wards.


A study of the variability associated with sampling peanuts for aflatoxin.


Sample preparation for aflatoxin assay: the nature of the problem and approaches to a solution.


Herd health management.

Herd health management.


Hypoxic poikilothermia in rats.

Hypoxic poikilothermia in rats.


Effect of expiratory flow rate on emptying of lung regions.


Effect of temperature and hemoglobin concentration on solubility of O2 in blood.


Effect of increased airway resistance on ventilation and gas exchange during exercise.


Thermal comfort in disparate thermal environments.


Comparison of changes in blood volume and opacity in dog digital pad and tongue.


Left ventricular internal diameter and cardiac function in conscious dogs.


Diffusion of argon, krypton, and xenon in olive oil.


Effects of fecal weight on thyroid function in cold-exposed rats.


Distribution component of alveolar-arterial oxygen pressure difference in man.


Nature of pleural space of dogs.

Nature of pleural space of dogs.


Differences in maximal and submaximal work capacity in men and women.


Mass excursion parameters of first heart sound energy.


Pulmonary venous admixture before, during, and after halothane: oxygen anesthesia in man.


Increased alveolar-arterial oxygen difference during simulated high-altitude exposure.


Muscular exercise and cholesterol degradation: mechanisms involved.


Dispersed fluorochemicals as substitutes for erythrocytes in intact animals.


Cardiovascular responses to sustained high skin temperature in resting man.


Energy expenditure in desert walks: man and burro Equus asinus.


Reactions of men working in hot and humid conditions.


Energy cost of loads carried on the head, hands, or feet.


Effect of training and exhaustion on hexokinase activity of skeletal muscle.


Responses to cold during a year in Antarctica.


Gaseous diffusion between airways and alveoli in the human lung.


Effect of hyperbaric oxygen on human sweat with particular reference to lactate content.


Metabolic responses to food and acute cold stress.


Method for measuring lung gas volume.

Method for measuring lung gas volume.


A mathematical study of thermal losses by sweating in man.


An analytic formula to instantaneously determine total metabolic rate for the human system.


A method for intracellular stimulation and recording using a single microelectrode.


A precision heart rate meter calibrator.


An intermittent pyloric occluder for obtaining complete gastric contents in dogs.


Use of intracardiac A-V nodal potentials in producing complete heart block in dogs.


Evaluation and correction of manometer systems with two degrees of freedom.


A joint angle detector.

A joint angle detector.


Sampling blood from freely swimming fish.


Stress-strain relations of tissue sheets undergoing uniform two-dimensional stretch.


Silastic skin button for chronic exteriorization of tubing in dogs.


Directional valves for multiple gas collections.


Comparison of methods for calculation of left ventricular stroke work.


A thermode-electrode for physiological studies of highly discrete tissue loci.


Effect of phosphate on the digestion of ribonuclease T1 with proteases.


The effect of D-glucosamine on the adenine and uridine nucleotides of sarcoma 180 ascites tumor cells.


Mobilization of liver iron by ferroxidase (ceruloplasmin).


Staff-resident communication in nursing homes: a factor analysis of staff attitudes and resident evaluations of staff.


Monotic vs. diotic presentation of dichotic speeded speech.


Cyclic fluctuations in sexual responsiveness in the male rat.


The metabolism of [4-14C]cholesterol in the pre-viable human foetus.


Isolation, cultivation and characterization of flexibacteria.


Deoxyribonucleic acid base composition of flexibacteria.


Recurrent group analysis in the classification of flexibacteria.


A classification of flexibacteria.

A classification of flexibacteria.


Numerical taxonomy of the flexibacteria.


Cell wall analysis of oral filamentous bacteria.


Surface appendages similar to fimbriae (pili) on pseudomonas species.


Failure of putative nitrogen-fixing bacteria to fix nitrogen.


Theory and techniques for a therapeutic milieu.


Suicide as communication: Adler's concept and current applications.


Mexican character: an Adlerian interpretation.


Self concept decline from psychiatric hospitalization: a critique.


Mites of the genus Laelaps of New Guinea (Acari: Mesostigmata: Laelapidae).


An unusual new genus and species of Macronyssidae (Acarina) parasitic on a disc-winged bat.


Dual infections of mosquitoes with strains of West Nile virus.


Divided-eye, a sex-linked mutation in Culex pipiens L.


Sexual dimorphism in Aedes nigromaculis adults with descriptions of gynandromorphs (Diptera: Culicidae).


Histological responses of cattle and other ruminants to the recent attachment of ixodid larvae.


Further studies on the arthropod host range of arboviruses.


The growth and serial passage of cell lines from Aedes aegypti (L.) larvae in different media.


An automated method for the direct determination of total serum cholesterol.


Lung scanning using 99mTc-labeled macroaggregated ferrous hydroxide (Tc-MAFH) as the perfusion agent.


Progress in the recording of human retinal and occipital potentials.


Diffusion model of linear flicker responses.


Fourier analysis and color discrimination.


Test of scotopic suppression of the photopic process.


Remodelling of periosteal lesions induced by surgical stimulation or beta-aminopropionitrile administration.


Histology and prognosis in malignant melanoma.


An electron-microscope study of liver cell necrosis due to heliotrine.


Intimal hyperplasia of the aorta and renal vessels in an infant with hypertension.


An electron-microscope study of the relations between mast cells and eosinophil leucocytes.


Ciliated epithelium in a cyst of the lower limb.


Why patients don't follow medical advice: a study of children on long-term antistreptococcal prophylaxis.


A simple indirect method of detecting the enzyme defect in histidinemia.


Comment on "The ambiguity of TAT ambiguity".


Reply to Murstein's "Comment on 'The ambiguity of TAT ambiguity'".


A procedural critique of "Bender Gestalts of organic children: accuracy of clinical judgment".


Body boundary and psychological control in an arthritic population.


The anal character and social severity in attitudes.


The Loyola Seminarian Sentence Completion Test.


Volunteering for a high-demand, low-reward project: sex differences.


Rorschach indices of love, aggression and happiness.


Personality and esthetic sensitivity.

Personality and esthetic sensitivity.


Limited sensory and social deprivation and operant control of affiliation and deference responses.


Consensus Rorschach in the primary classroom.


Obscure hepatomegaly. A clinico-pathological study.


Vascularization of the rabbit's ureter after ligation of its normal arterial supply.


Serological relatedness of the ribonucleic acid-containing coliphages. The serological relationship of the ribonucleic acid (RNA)-containing coliphages MS-2, M-12, R-17, f(2), beta, fr, f(4), and Qbeta was determined. Antisera against MS-2, R-17, f(2), fr, and Qbeta neutralized the infectivity of all of these RNA phages to varying degrees. Although each phage was serologically distinct, the antisera cross-reacted with certain phages to approximately the same degree, indicating the antigenic relationship of the coat proteins of these phages. Adsorption of anti-MS-2 sera with varying concentrations of all of the phages demonstrated that these viruses contain similar yet unique antigenic determinants. It is suggested that these RNA phages are mutants of two related phages rather than of the same phage.


Synthesis of vaccinia viral proteins in cytoplasmic extracts. II. Identification of early and late viral proteins. The synthesis of vaccinia viral proteins has been studied in a cell-free system prepared from vaccinia virus-infected HeLa cells. The radioactively labeled proteins were identified as viral proteins by immunodiffusion, disc gel electrophoresis, and disc gel-immunoelectrophoresis. The cytoplasmic extracts, obtained from infected cells at different times during viral replication, synthesized the corresponding "early" or "late" viral proteins.


Capsid mosaics of intermediate strains of human adenoviruses. Antisera against isolated capsid components of intermediate adenovirus strains, types 3-16 (the San Carlos agent) and 15-9 and of "parental" prototype strains were compared in neutralization tests, hemagglutination-inhibition (HI) tests employing soluble and virion-associated hemagglutinin as antigens, and by electron microscopy. Hexons of the intermediate strains were found to be similar to, but not identical to, those of the prototype strains with which a cross-reaction occurred in neutralization tests (types 3 and 15). In contrast, fibers of intermediate strains displayed characteristics relating them to the corresponding components of prototype strains to which a relationship has been found in HI tests. Fibers (and possibly even pentons) of types 9 and 15-9 appeared to be identical, whereas fibers of types 3-16 and 16 displayed antigen specificities of both common and unique nature.


Transcription and replication of viral deoxyribonucleic acid in cells coinfected with adenovirus types 2 and 12. The yield of infectious virus was determined for KB cells infected with both adenovirus types 2 (ad 2) and 12 (ad 12). It was found that the yield of the former was greatly reduced, whereas that of the latter was not affected significantly. The reduction in virus yield was accompanied by an inhibition of ad 2 virus-specific ribonucleic acid (RNA) and viral deoxyribonucleic acid (DNA) synthesis at various times after infection. On the other hand, the rate of synthesis of ad 12 virus-specific RNA and viral DNA was not inhibited, but advanced in time. The total amount of ad 12 viral DNA synthesized was not affected by coinfection with ad 2. These results suggest that ad 2 infection hastens the maturation of ad 12.


Immunological relationships between hexons of certain human adenoviruses. Antisera against hexons of serotypes 2, 4, 5, and 6 (subgroup III), and 15 (subgroup II) were absorbed with purified hexons of various serotypes representing the different subgroups of human adenoviruses. Group, subgroup, and type specificities of hexons could be distinguished. The subgroup specificity of type 4 hexons resembled that of hexons of subgroup I members (types 3, 11, and 16). Antihexon sera gave a type-specific inhibition of virion-associated hemagglutinin. The inhibiting activity of different sera was found to be inversely related to the length of fibers of the serotype concerned. Virions of serotypes carrying fibers shorter than about 20 nm (types 3, 4, 9, 11, and 15) were readily inhibited, whereas those of serotypes with longer fibers (types 2 and 6) were inhibited only by relatively large amounts of antibody measured in terms of homotypic complement fixation activity. The reciprocal cross-neutralization between serotypes 4 and 16 was studied separately. Hexons of both serotypes each carried a type-specific component and, in addition, a unique antigen specificity common to the two types. This common antigen specificity was interpreted to be available to a larger extent at the surface of virions (and probably also isolated hexons) of type 4 than of type 16. These results suggest an explanation for the predominantly one-sided character of the cross-neutralization between types 4 and 16.


Biophysical properties of Australia antigen. Biophysical studies with Australia complement-fixing (CF) antigen showed it to be a particle with a buoyant density of 1.20 g/cm(3) in CsCl, a sedimentation coefficient of 110, and an average diameter of 25 nm. The CF antigen was not inactivated by ether, 1% deoxycholate, 1% Tween 80 or overnight heating at 56 C. The antigen was unstable when treated with 1% sodium dodecyl sulfate. A procedure is described for the isolation and partial purification of Australia antigen from serum by using isopycnic banding and rate separation techniques. Treatment of the 1.20 g/cm(3) Australia antigen with 1% Tween 80 yielded a minor peak of CF activity with a buoyant density of 1.39 g/cm(3) in CsCl.


Isolation of two plaque mutants of Western equine encephalitis virus differing in virulence for mice. Two plaque mutants were isolated from tissue cultures infected persistently with Western equine encephalitis virus. A large plaque mutant proved to be markedly avirulent for mice.


Immunological and other biological characteristics of pentons of human adenoviruses. Comparative hemagglutination-enhancement (HE) tests demonstrated diversified patterns of antigenic specificities both in the fiber and vertex capsomer part of pentons of human adenovirus types 3, 11 (subgroup I), 9, 15 (II), 1, 2, 4, 5, 6 (III), and 12. All fibers contained a type-specific antigen. Subgroup II and III fibers, in addition, contained specificities both unique for each subgroup and also common to the two subgroups. Fibers of serotypes 4 and 12 displayed a somewhat deviating behavior. All vertex capsomers tested shared a group-specific part. This was the only antigenic specificity demonstrable for serotype 12. Maximal penton HE titers of all sera were reached in tests with incomplete hemagglutinin of type 11. In addition, maximal HE activity of sera against individual serotypes also was recorded against pentons of other members of the same subgroup. Antigen characteristics of vertex capsomers of type 4 indicated a closer relationship to subgroup I than to subgroup III. The toxin activity of pentons was more sensitive to trypsin treatment than their capacity to function as incomplete hemagglutinin. Homotypic antipenton sera, unabsorbed or absorbed with homotypic fibers to remove antibodies against this component, and, to a varying extent, also heterotypic antipenton sera could neutralize toxin activity. Antifiber sera could neutralize toxin activity of pentons carrying short fibers (10 nm, type 3) but not of those carrying long fibers (28 to 31 nm, type 2). It is concluded that toxin activity is carried by a specific part of vertex capsomers and that cell detachment can be brought about via a direct contact between this component and cell membranes. Fiber-mediated attachment does not seem to be necessary for this biological activity to become expressed.


Structure and development of viruses as observed in the electron microscope. V. Entry and uncoating of adenovirus. Stages in the direct penetration of adenovirus through the cell membrane are illustrated. Phagocytosis with rupture of the vacuole and release of virus into the cytoplasm may also account for entry of some particles. Uncoating by digestion within phagosomes was not observed. Rather, alteration of capsid and core occurred to virions free in the cytoplasm. Nucleoprotein released from virus close to the nucleus was transported to the nuclear matrix by a unique mechanism. These events were not prevented by puromycin and hence were not dependent upon the synthesis of new enzymes. They were, however, energy-dependent.


Electrophoresis of adenovirus-specified thymidine kinase. Stimulation of thymidine kinase (TK) activity occurs after abortive or productive infection with human adenoviruses. Striking changes in TK electrophoretic profile accompany this stimulation.


The ultrastructure of globoid (Krabbe) leukodystrophy.


Some deficiencies of Carcinus maenas (L.) as an experimental animal.


Anaemia in pregnancy in Western Australia.


Toxicity of interferon inducers of the double stranded RNA type.


Relationships between the effects of poly I. poly C and endotoxin.


Photoconductivity in black lipid and thin lipid membranes.


HEPES-buffered medium for organ culture.


Effect on the superior colliculus of cortical removal in visually deprived cats.


Antlers--the bones of contention.

Antlers--the bones of contention.


Musk odour and far infrared vibration frequencies.


Cyclamates.

Cyclamates.


Diagnosis of Tay-Sachs.

Diagnosis of Tay-Sachs.


Polypeptide chain initiation: nucleotide sequences of the three ribosomal binding sites in bacteriophage R17 RNA.


Sequence of a ribosome binding site in bacteriophage Q-beta-RNA.


What will happen to the scientific literature?


Application of the Lifshitz theory to the calculation of Van der Waals forces across thin lipid films.


Is Tay-Sachs disease increasing?

Is Tay-Sachs disease increasing?


Nonoliguric renal failure. Report of a case.


Drug therapy of essential hypertension.

Drug therapy of essential hypertension.


Histochemistry, refractometry, and fine structure of excretory globules in larval malpighian tubes of Melipona quadrifasciata (Hym., Apoidea).


Time-lapse and electron microscopic studies of sea urchin micromeres.


An analysis of a peer network using psychedelic drugs.


Community psychiatry welcomes the nonprofessional.


Schizophrenia as a diagnosis and disease process. A theoretical overview.


Long-term follow-up of schizophrenics admitted to a general hospital psychiatric ward.


The sorcerer's apprentices.

The sorcerer's apprentices.


Crystalline transfer RNA: the three-dimensional Patterson function at 12-angstrom resolution. An orthorhombic form of crystalline formylmethionine transter RNA has been obtained which contains one molecule as the asymmetric unit of the unit cell. Three-dimensional x-ray diffraction data have been collected up to a resolution of 12 angstroms, and from this a Patterson function has been calculated. The function contains an elongated ridge of interatomic vectors parallel to the c-axis of the crystal. Analysis of the function suggests that the molecules are elogated and dimerized in an overlapping antiparrael fashion along the c-axis. The dimer has a length near 109 angstroms and a width of 35 angstroms in one direction. The individual molecular length is approximately 80 angstroms with an irregular cross section measuring 25 by 35 angstrms.


Cytosine to thymine transitions from decay of cytosine-5-3H in bacteriophage S13. Decay of cytosine-5-(3)H incorporated into bacteriophage S13 DNA causes a molectular rearrangement of the cytosine molecutle undergoing the decay. The molecular rearrangement produces a cytosine to thyimine coding change with at efficiency approaching one. Decay of either thymidine-(methyl)-(3)H or cytosine-6-(3)H is less than 1 percent as effective in calusing either cytosine to thymine or thymine to cytosine transitions.


Microtubular protein: synthesis and metabolism in developing brain. In the developing mouse brain 40 percent of the labeled soluble protein found found after injection of leucine-C(14) consists of subunits with a molecular weight of 60,000 and with other characteristics of microtubular protein. This protein has a half-life of about 4 days.


Pompe's disease: detection of heterozygotes by lymphocyte stimulation. A technique has been developed for the detection of inborn errors by multiple enzyme analysis of lymphocytes stimulated by phytohemagglutinin. Its practicality has been demonstrated in Pompe's disease in which there is a deficiency of acid alpha-1,4-glucosidase (E.C.3.2.1.20).


Self-assembly of Q-beta and MS2 phage particles: possible function of initiation complexes. Four kinds of particles were reconstituted with RNA and protein from the genetically unrelated bacteriophages Qbeta and MS2, namely, two homologous and two heterologous, with respect to RNA and protein. However, once Qbeta RNA (or MS2 RNA) reacted with a few molecules of either Qbeta or MS2 protein to form a nucleoprotein complex (initiation complex), it formed a phagelike particle only with subsequent addition of the same protein.


Permeability and structure of junctional membranes at an electrotonic synapse. The dye Procion Yellow M4RS crosses junctional membranes from cytoplasm to cytoplasm at electrotonic synapses between segments of the crayfish septate axon. The dye does not enter the cells from extracellular space. Thus permeability of junctional membranes is qualitatively different from that of nonjunctional membranes. Electron microscopy after fixation in the presence of lanthanum hydroxide indicates that these synapses are "gap junctions" and that there is a network of channels continuous with extracellular space between apposed junctional membranes. These channels must be interlaced with intercytoplasmic channels that are not open to extracellular space.


Hemoglobin as a tracer in hemodynamic pulmonary edema. Stroma-free hemoglobin is an electron-opaque molecule useful as a tracer for the ultrastructural stuty of pulmonary capillary permeability. After this tracer was infused into the isolated pulmonary lobe of the dog, the endothelial junctions of the capillaries, as revealed by electron microscopy, act like distensible pores, thus allowing the tracer to escape when the pulmonary artery pressure was raised above 50 millimeters of mercury.


Rhapidosomes: absence of a highly 2'-O-methylated RNA component. Rhapidosomes of Saprospira grandis do not contain RNA that is highly methylated at the 2'-oxygen of the sugar residues. Neither is such an RNA associated with the particles as a contaminant. A cursory examination of the rhapidosomes of two other marine organisms gave similar results.


Antibodies to polynucleotides: distribution in human serums. Hemagglutination procedures were used to determine the distribution of antibodies to native DNA, single-stranded DNA, and double-stranded RNA. Antibodies to all three polynucleotides were found in a high percentage of the serums of patients with systemic lupus erythematosus. Antibodies to native DNA occurred almost exclusively in serums of patients in the active stages of systemic lupus erythematosus, whereas antibodies to single-stranded DNA were observed in the serums of patients with several diseases and of some normal individuals.


Buoyancy control in the freshwater turtle, Pseudemys scripta elegans. Freshwater turtles (Pseudemys scripta elegans) significantly corrected experimental displacements of their specific gravity. By reciprocally changing the volumes of lung air and stored water, they set their buoyancy and maintained their body volume. The cloacal bursae may be the active site for water storage and exchange in this mechanism.


Respiration and deep diving in the bottlenose porpoise. A bottlenose porpoise was trained to dive untethered in the open ocean and to exhale into an underwater collecting funnel before surfacing from prescribed depths down to 300 meters. The animal was also taught to hold its breath for periods up to 4 minutes at the surface and then blow in the funnel. Alveolar collapse is probably complete at around 100 meters, and little pulmonary respiratory exchange occurs below that depth. Thoracic collapse was observ visually at 10 to 50 meters and by underwater television to 300 meters.


Climate and evolutionary rate.

Climate and evolutionary rate.


Dialects in elephatn seals.

Dialects in elephatn seals. Threat vocalizations of male elephant seals Mirounga angustirostris vary among four populations on islands off the coast of California and Baja California, Mexico. Males at San Nicolas Island in Southern California emit sound pulses at more than double the rate of males at Aũo Nuevo Island, 528 kilometers north. Mean pulse rates at San Miguel Island and Isla de Guadalupe (408 and 944 kilometers south of Aũo Nuevo, respectively) are intermediate to these two. Pulse rate is homogeneous within each population and consistent in the same individual. Other properties of the calls which separate populations are pulse duration and embellishment of the initial or terminal pulse in a series. These geographical differences in vocal behavior resemble local dialects in birds and humans.


Enzyme nomenclature: new edition planned.


Sociology and the study of psychiatric disorder.


Optically active organophosphoramides. O-2,4-dichlorophenyl O-methyl isopropylphosphoramidothioate and some related compounds.


Visual pigments of the burbot, Lota lota, and seasonal changes in their relative proportions.


The transfer functions of sensory intensity in the nervous system.


Nonlinearities of the human oculomotor system: gain.


Further properties of the human saccadic system: eye movements and correction saccades with and without visual fixation points.


Effect of reduced retinal illuminance on the pupillary near reflex.


Interocular hue shifts and pressure blindness.


Inhibitory and sub-liminal excitatory receptive fields of simple units in cat striate cortex.


Binocular corresponding receptive fields of single units in the cat dorsal lateral geniculate nucleus.


Pre-excitatory inhibition in the stirnorgan of the bullfrog.


Border-contrast: corner brightening effects.


Heterogeneity of the human haptoglobin 1-1 molecule by electrophoresis of serum in starch gels at pH 4.9.


Polysaccharides elaborated by Polyporus borealis (Wahlenb.). 1. Water-soluble neutral polysaccharides from the fruit bodies.


Structural studies on the O-specific side chains of the cell wall lipopolysaccharides from Salmonella typhi and S. enteritidis.


Mass spectrometry of phenylthiohydantoin (PTH) amino acids.


Polysaccharides elaborated by Polyporus ovinus (Schaeff). 1. Structure of a fucogalactan from the water extracts of the fruit bodies.


Evidence suggesting independent pathways for the synthesis of rat liver fatty acids from acetyl-CoA and malonyl-coA respectively.


Correlation between amount of aggregates formed on freezing of immunoglobulin G and protein concentration.


An improved preparation of cellulose layers for the thin-layer chromatography of amino acids.


Positive immuno-reactions in a case of unilateral scleroderma or progressive hemiatrophy.


Disappearance of 22NaCl and 131-I-hippuran from immobilized joints in rabbits.


The fate and distribution of intra-articularly injected osmium tetroxide (Os-191).


Curare sensitivity and myastheniform symptoms in patients with rheumatoid arthritis.


The LED (SLE) patient and the doctor. A study of the diagnostic process in 45 patients.


Erythromucoid and plasmamucoid in ankylosing spondylitis.


The reaction of rheumatoid factor with various animal IgG globulin.


Wrist and finger deformities in juvenile rheumatoid arthritis.


Ankylosing spondylitis and osteitis condensans ilii.


Effect of 5-hydroxytryptamine on morphine analgesia in rabbits.


Half-lives of isoniazid and salicylic acid in serum and their modification by different drugs in psychiatric patients.


Biogenic amines, cold-adaptation and halothane shivering in mice.


Development of some enzymes involved in gluconeogenesis in human liver.


A sensitive method for determination of serum guanine deaminase activity.


Influence of the duration of deoxycorticosterone and sodium chloride treatment on blood pressure and metabolic events in the rat.


The physiological explanation of split parturition in the pig and other mammalian species.


Formation of thyroid hormone by the thyroid gland in vitro and during electrophoresis. I. Experiments on bovine glands.


The estimation of heritability for the self-selection of alcohol in the albino rat.


Formation of thyroid hormone by the thyroid gland in vitro and during electrophoresis. II. Experiments with rat tissues.


Regression of experimental skin tumours.


The effect of reserpine on the regional 5-hydroxytryptamine content of the rat gastrointestinal tract.


Studies on the conversion of 60s yeast ribosomes into a 50S component. The process of conversion of the larger (60s) subunit of yeast ribosomes into a 50s component was studied. The release of any RNA or protein material during conversion was assayed by using (32)P- or (35)S-labelled ribosomes; ribosomal RNA distributions of the particles were examined and protein/RNA ratios of subunits were determined. The change in sedimentation coefficients was found to be due, not to loss of material, but to a structural change. The change in structure was shown by electron microscopy.


Chemical and biological properties of mycobactins isolated from various mycobacteria. Nine different strains of mycobacteria grown on media deficient in iron all produced mycobactins. Most strains produced one mycobactin in great preponderance. Mycobacteria from clearly distinct taxonomic groups gave mycobactins differing in the structure of their nuclei. One group of taxonomically related mycobacteria produced mycobactins having the same nucleus but with different distributions of side chains within the homologous mixtures. Simple methods are described for identifying mycobactins on a small scale; these may be of value in classifying mycobacteria. Structures are proposed for mycobactin A from Mycobacterium aurum, mycobactin R from M. terrae, mycobactin F, produced together with mycobactin H by M. fortuitum, and mycobactins M and N from M. marinum. The first three of these differ from known mycobactins in details of substitution and configuration of asymmetric centres in the nucleus. Mycobactins M and N are substantially different, having only small acyl groups (acetyl and propionyl respectively) at the hydroxamic acid centre of the mycobactic acid moiety. Both are homologous mixtures having long-chain saturated 3-hydroxy-2-methyl acid fragments in the cobactin moiety. All mycobactins so far isolated promote almost maximal growth of M. johnei at 30ng./ml. in liquid medium. The activity of some mycobactins extends to much lower concentrations, mycobactin S showing significant growth promotion at 0.3ng./ml. Mycobactin M or N in combination with mycobactins having a long side chain in the mycobactic acid moiety exerts a mutually antagonistic effect on the growth of M. johnei, the mixture giving less growth than either mycobactin separately. Mycobactin M also decreases the growth of M. kansasii and M. tuberculosis on liquid media. These antagonistic effects are probably caused by a lengthening of the lag phase.


Identification of mycobactins by nuclear-magnetic-resonance spectroscopy. Details are given of the n.m.r. spectra of mycobactins F, H, M, N, P, S and T, and resonances are ascribed to all the protons in these molecules. A simplified system is described for identifying known mycobactins by the n.m.r. spectrum alone. This method will not distinguish mycobactins S and T, whose nuclei differ only in the configuration at an asymmetric centre.


The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells. 1. The pentose phosphate pathway in Krebs ascites cells was investigated for regulatory reactions. For comparison, the glycolytic pathway was studied simultaneously. 2. Activities of the pentose phosphate pathway enzymes were low in contrast with those of the enzymes of glycolysis. The K(m) values of glucose 6-phosphate dehydrogenase for both substrate and cofactor were about four times the reported upper limit for the enzyme from normal tissues. Fructose 1,6-diphosphate and NADPH competitively inhibited 6-phosphogluconate dehydrogenase. 3. About 28% of the hexokinase activity was in the particulate fraction of the cells. The soluble enzyme was inhibited by fructose 1,6-diphosphate and ribose 5-phosphate, but not by 3-phosphoglycerate. The behaviour of the partially purified soluble enzyme in vitro in a system simulating the concentrations of ATP, glucose 6-phosphate and P(i) found in vivo is reported. 4. Kinetics of metabolite accumulation during the transient state after the addition of glucose to the cells indicated two phases of glucose phosphorylation, an initial rapid phase followed abruptly by a slow phase extending into the steady state. 5. Of the pentose phosphate pathway intermediates, accumulation of 6-phosphogluconate, sedoheptulose 7-phosphate and fructose 6-phosphate paralleled the accumulation of glucose 6-phosphate. Erythrose 4-phosphate reached the steady-state concentration by 2min., whereas the pentose phosphates accumulated linearly. 6. The mass-action ratios of the pentose phosphate pathway reactions were calculated. The transketolase reaction was at equilibrium by 30sec. and then progressively shifted away from equilibrium towards the steady-state ratio. The glucose 6-phosphate dehydrogenase was far from equilibrium at all times. 7. Investigation of the flux of [(14)C]glucose carbon confirmed the existence of an operative pentose phosphate pathway in ascites cells, contributing 1% of the total flux in control cells and 10% in cells treated with phenazine methosulphate. 8. The pentose phosphate formed by way of the direct oxidative route and estimated from the (14)CO(2) yields represented 20% of the total accumulated pentose phosphate, the other 80% being formed by the non-oxidative reactions of the pentose phosphate pathway. 9. The pentose phosphate pathway appears to function as two separate pathways, both operating towards pentose phosphate formation. Control of the two pathways is discussed.


Liver-L-alanine-glyoxylate and L-serine-pyruvate aminotransferase activities: an apparent association with gluconeogenesis.


The transport of L-histidine across rat small intestine in vitro: an effect of semi-starvation and energy substrate requirements.


The role of polyribosomes in the biosynthesis of glycoprotein.


Fatty acid composition of the phosphatidylcholine fractions of denervated and tendonectomized rat skeletal muscle.


Cytochrome P-450 in the omega-oxidation of fatty acids.


Induction of drug-metabolizing enzymes and cytochrome P-450.


Oestrogen-receptor interaction in target tissues.


The effect of nutrition and hormonal status on cytochrome P-450 and its induction.


Oestradiol-17beta binding: some unresolved problems.


Metabolism of testosterone and activity of metabolites in prostate organ culture.


Lysosomes, chromosomes and cancer.

Lysosomes, chromosomes and cancer.


Lysosomes and congenital malformations.

Lysosomes and congenital malformations.


Secretory activities of cells in culture: the effect of ouabain.


N-acetyl-beta-D-glucosaminidase activity in Congo Red-induced arthritis.


Factors affecting the changes in activities of some hepatic enzymes during development of the rat.


Activity of aminotransferases in the tissues of developing lambs.


Active-site thiol groups of yeast hexokinase.


An assay for liver glutamine aminotransferase.


Species body size and liver glutamine synthetase, glutaminase and glutamine aminotransferase.


Investigation of the cathepsins of human gastric carcinomata.


Regulations of penicillinase synthesis in Bacillus licheniformis: binding of inducer to cells, and the half-life of the messenger ribonucleic acid.


Four classes of steroid identified by their interaction with mineralocorticoid receptors in the toad bladder.


Effects of oestrone and oestradiol on rat and rabbit uterus in organ culture.


Changes in mitochondrial structure and ribosomal activity in muscle as a consequence of the interaction between a glucocorticoid and some anabolic steroids.


Purification of an oestrophilic protein from calf uterus.


The use of protamine for a simple test of oestradiol-17beta binding.


Fractionation of chromatin from dimethylbenzanthracene-induced rat mammary adenocarcinoma.


Acetoacetate formation in bovine tissues.


Rat liver beta-xylosidase, a lysosomal membrane enzyme.


Acid phosphatases in rat heart.

Acid phosphatases in rat heart.


Latency of endogenous and exogenous lysosomal glucosidases.


Lysosomal uptake of actinide elements.

Lysosomal uptake of actinide elements.


Observations on [35S] sulphated insulins.


Effects of suramin and aurothiomalate on rat liver lysosomes.


The subcellular acquisition of carbohydrates by glycoproteins.


Studies on sialoglycoprotein complexes of human erythrocyte membranes.


Increased drug-metabolizing activity without increased cytochrome P-450 in rats treated with phenolic antioxidants.


Quinate metabolism by lactobacilli.

Quinate metabolism by lactobacilli.


The effect of intraductal prolactin on protein and nucleic acid biosynthesis in the rabbit mammary gland.


Metabolites of sulphadimethoxypyrimidine in the urine of various species.


Bile secretion in relation to decreases in liver adenosine triphosphate concentration in the rat.


Reabsorption from the biliary system as a factor influencing the biliary excretion of organic anions.


A quantitative study of a reduced ovomucin-natural lysozyme interaction.


A reduced ovomucin-reduced lysozyme complex from egg white.


The digestive capacity of rat yolk-sac in organ culture.


Rates of effux and intracellular concentrations of potassium, sodium and chloride ions in isolated fat-cells from the rat. 1. The metabolism of K(+), Na(+) and Cl(-) has been investigated in isolated fat-cells prepared from the epididymal adipose tissue of rats. 2. Methods are described for measuring the intracellular water space, the rates of loss of intracellular (42)K(+), (22)Na(+) and (36)Cl(-) and the intracellular concentrations of K(+), Na(+) and Cl(-) in isolated fat-cells. 3. The intracellular water space, measured as the [(3)H]water space minus the [carboxylic acid-(14)C]inulin space, was 3.93+/-0.38mul./100mg. cell dry wt. 4. The first-order rate constants for radioisotope effluxes from isolated fat-cells were 0.029min.(-1) for (42)K(+), 0.245min.(-1) for (22)Na(+) and 0.158min.(-1) for (36)Cl(-). 5. The intracellular concentrations of K(+), Na(+) and Cl(-) were 146m-equiv./l., 18.6+/-2.9m-equiv./l. and 43+/-2.4m-equiv./l. respectively. 6. The total intracellular K(+) content of isolated fat-cells was determined by atomic-absorption spectrophotometry to confirm the value obtained from the radioisotope-efflux data. 7. The ion effluxes from isolated fat-cells were: K(+), 1.5pmoles/cm.(2)/sec., Na(+), 1.6pmoles/cm.(2)/sec., and Cl(-), 2.4pmoles/cm.(2)/sec. 8. The membrane potential of isolated fat-cells calculated from the Cl(-) distribution ratio was -28.7mv.


Effect of cholesteryl 14-methylhexadecanoate on the activity of some amino acid-transfer ribonucleic acid ligases from mammalian tissues. 1. l-Tyrosine-, l-alanine-, l-tryptophan- and l-threonine-tRNA ligases (where tRNA is transfer RNA) were purified from mammalian tissues and the relative contents of cholesteryl 14-methylhexadecanoate were determined in fractions obtained during the isolation. Purified enzymes were extracted with various organic solvents. 2. Cholesteryl 14-methylhexadecanoate contents in purified ligases were up to 210-fold that in the starting material. Different enzymes showed different contents of this cholesteryl ester. 3. Extracted enzymes lost in most cases their ability to catalyse formation of the aminoacylhydroxamate and aminoacyl-tRNA complexes. Enzymes extracted with various solvents showed a variable decreased activity. 4. The original activity could be restored to 70-100% by the addition of cholesteryl 14-methylhexadecanoate. Cholesteryl palmitate, cholesteryl margarate and cholesteryl stearate were inactive in this respect. 5. Incubation mixtures of extracted enzymes with cholesteryl 14-methylhexadecanoate added showed an initial delay in the time-course of both reactions assayed. 6. It is concluded that the effect of cholesteryl 14-methylhexadecanoate on the activity of amino acid-tRNA ligases seems to be specific and that this compound may play some role in the function of these enzymes.


The metabolism of [14C] nicotine in the cat. The metabolism of [2'-(14)C]nicotine given as an intravenous injection in small doses to anaesthetized and unanaesthetized cats has been studied. A method is described for the quantitative determination of [(14)C]nicotine and [(14)C]cotinine in tissues and body fluids. Nanogram amounts of these compounds have been detected. After a single dose of 40mug. of [(14)C]nicotine/kg., 55% of the injected radioactivity was excreted in the urine within 24hr., but only 1% of this radioactivity was unchanged nicotine. [(14)C]Nicotine is metabolized extremely rapidly, [(14)C]cotinine appearing in the blood within 2.5min. of intravenous injection. [(14)C]Nicotine accumulates rapidly in the brain and 15min. after injection 90% of the radioactivity still represents [(14)C]nicotine. Metabolites of [(14)C]nicotine have been identified in liver and urine extracts. [(14)C]Nicotine-1'-oxide has been detected in both liver and urine.


The solubilization of collagen and protein-polysaccharides from the developing cartilage of lathyritic chicks. 1. The solubilization of collagen and protein-polysaccharides from the developing cartilage of normal and lathyritic chicks was studied by using mild extraction procedures. One-third of the protein-polysaccharides could be solubilized in salt solutions at neutral pH from normal cartilage, whereas 95-100% could be extracted from the cartilage of animals that were severely lathyritic. Likewise, whereas in normal animals the collagen of cartilage was essentially insoluble in salt solutions at neutral pH, in lathyritic animals it was almost completely soluble. 2. The increased solubility of the collagen of cartilage from lathyritic animals enabled sufficient material to be collected so that the pure alpha1 chains of the collagen were isolated by repeated reconstitution, precipitation and CM-cellulose column chromatography. The purified alpha1 component was characterized by its relatively high content of hydroxylysine (14 residues/1000 amino acids). 3. About 37% of the collagen from the cartilage of normal chick embryos could be extracted as the gelatin at pH7.4 in lithium chloride solution. This was accompanied by the extraction of approx. 14% of the protein-polysaccharide content. 4. The protein-polysaccharides and the collagen from normal animals could be extracted from the cartilage relatively independently of one another under mild conditions. These same components obtained from lathyritic animals easily separated from one another after solubilization. This provided evidence that the two components are probably not covalently cross-linked. 5. The collagen of cartilage extracted as a gelatin from normal animals contained a high proportion of alpha chains compared with beta dimers, similar to the lathyritic collagen of cartilage and other tissues, and similar to the gelatin extracted from normal chick bone.


Schiff bases formed from retinal and phosphatidylethanolamine, phosphatidylserine, ethanolamine or serine. 1. Conditions were established for the reaction of retinal with phosphatidylethanolamine, phosphatidylserine, ethanolamine and serine in chloroform, ethanol or ethanol-water solutions to form retinylidene compounds, or Schiff bases. 2. The Schiff bases were reduced to retinyl compounds with sodium borohydride. 3. Absorption maxima and molar extinction coefficients were determined for the various retinylidene and retinyl compounds and for the corresponding coloured products formed by their reaction with antimony trichloride.


Glutathione S-aralkyltransferase.

Glutathione S-aralkyltransferase. 1. The name ;glutathione S-aralkyltransferase' is proposed for the enzyme catalysing the reaction of benzyl chloride with GSH. 2. Results from heat-inactivation studies, ammonium sulphate-fractionation and acid-precipitation experiments, and studies of the distribution of activities in rat liver, in rat kidney and in the livers of other animals indicate that glutathione S-aralkyltransferase differs from glutathione S-alkyltransferase, S-aryltransferase, S-epoxidetransferase and an S-alkenetransferase. 3. The distribution of these enzymes in the livers of the animal species examined was different. 4. Glutathione S-alkyltransferase, S-aralkyltransferase and the S-alkenetransferase that are present in rat liver supernatant were inhibited by GSSG, and the nature of the inhibition varied in each case. 5. 3,5-Di-tert.-butyl-4-hydroxybenzyl acetate reacts spontaneously with GSH, but the rat liver-supernatant-catalysed reaction of GSH with this and other aralkyl esters was weak. 6. A probable function of the glutathione S-transferases is the protection of cellular constituents from strong electrophilic agents.


Changes in lipid pattern of HeLa cells exposed to immunoglobulin G and complement. 1. Immunoglobulin G was isolated from sera of non-immunized rabbits or rabbits immunized with whole HeLa cell homogenate. The anti-HeLa immunoglobulin G and its Fab fragment precipitated the particulate 400000g-min. fraction of HeLa cell homogenate. 2. Immunoglobulin G from immunized or non-immunized rabbits and fresh or inactivated complement were added to HeLa cell cultures. Changes in the cell count and cellular contents of DNA, RNA, protein, total and individual phospholipids, cholesterol (and esters) and ganglioside were followed. 3. Addition of immunoglobulin G from non-immunized rabbits and guinea-pig serum (complement) caused a transient increase in DNA followed by a permanent increase in RNA, protein, dry weight and number of cells per culture. 4. Addition of anti-HeLa immunoglobulin G and active complement caused an increase in the cellular content of cholesterol, total phospholipids, lysophosphatidylcholine and lysophosphatidylethanolamine greater than the increase of the controls and a decrease in the molar percentages of phosphatidylcholine and phosphatidylethanolamine as compared with the controls. 5. The cholesterol/phospholipid ratio remained constant. 6. The appearance of lysophosphoglycerides was transient, reaching a maximum 3hr. after addition of anti-HeLa immunoglobulin G. 7. The content of lysophosphoglycerides in HeLa cultures exposed to immunoglobulin G from non-immunized rabbits ranged from 50% to 30% of the values obtained from cultures exposed to the anti-HeLa immunoglobulin G and complement. 8. The changes in the lipid pattern of the HeLa cells were associated with the appearance of juxta-nuclear vacuoles in cells, but were apparently not specifically related to the presence of active complement.


Population retested for diabetes after 17 years: new prevalence study in Oxford, Massachusetts.


The control of diabetes in summer campers, with special reference to acetone bodies.


High carbohydrate diet in the treatment of diabetes mellitus.


Evolution of diabetes after early testosterone treatment in rats.


Factors determining serum-insulin response in a population sample.


Insulin sensitivity of adipose tissue and of diaphragm in rats adapted to periodic hyperphagia.


Insulin in bile. The effect of monosaccharides and hypoglycaemic agents.


The reactivity and ultrastructure of conjunctival microaneurysms in diabetes.


Effects of propranolol on blood sugar, insulin and free fatty acids.


Dissociation of hyperglycaemia and obesity in mice fed high fat diets.


The significance of the blood glucose level for plasma insulin response to intravenously administered tolbutamide in healthy subjects.


Stimulation by insulin of the incorporation of U-14C-glucose into lipids released by the liver.


Dissolution kinetics of hydroxylapatites of calcium and strontium.


Confirmation of the effect of indole-3-acetic acid on citrate synthase.


Antimitotic agents and macronuclear division of ciliates. I. Colchicine and colcemid in exponentially growing cultures of Tetrahymena pyriformis GL.


Effect of zinc on mitosis.

Effect of zinc on mitosis.


Vinblastine-induced chromosomal alterations in cultured Chinese hamster cells.


Influence of steroids on the growth of the dwarf pea.


4-Allyloxy-3-chlorophenylacetic acid, a new type of analgesic, antipyretic and antiphlogistic drug.


Effect of estrone on the content of endogenous gibberellins in the dwarf pea.


Correlation analyses of behaviour patterns in Tilapia (Pisces, Cichlidae).


Reaction of CCCP in photosynthesis on an intermediate between chlorophyll-aII and water.


Differential effect of Dio-9 on non-cyclic photophosphorylation and 14C-fixation in vivo.


3,4-Dihydroxy-mandelic acid in the mushroom gland of cockroaches.


Sex-specific difference of alkaline phosphatase of Ehrlich's carcinoma cells.


Sinu-ventricular opening in the heart of a salamander.


Rehabilitation in a changing world.

Rehabilitation in a changing world.


The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia. I.


The stability of the cervical spine following the conservative treatment of fractures and fracture-dislocations.


The treatment of the paralysed bladder after spinal injury in the accident unit of Colmar.


The rehabilitation of paraplegics and tetraplegics in West Germany.


Rehabilitation of paraplegics in Austria.


Development of an autonomous spinal injuries unit.


Pregnancy and labour in high traumatic spinal cord lesions.


Treatment of paraplegic spasticity by muscle transplantation.


Carrageenan and delayed hypersensitivity. II. Activation of Hageman factor by carrageenan and its possible significance.


Enzymes for the formation of lecithins by transmethylation in the livers of developing rats.


Bile salt-induced permeability changes in the isolated rat intestine.


Synthesis of reovirus structural proteins.


Lipid changes in the chick hatching muscle.


Lymphoblastoid cell cultures from patients with infectious hepatitis.


Experimental histuria and histemia. Tissue macromolecules in blood and urine due to hepatic necrosis in rabbits.


The potency of anesthetics in frog gastric secretion in Cl-solutions.


Inhibitory effect of chlorothiazide on glucose utilization by aorta.


A pharmacological evaluation of a genetically predisposed conditioned avoidance response.


Effect of stimulation on pancreatic amylase secretion and nuclear RNA synthesis.


Amino acids and glucose in human blood plasma after beef and nonprotein meals.


Prostaglandin inhibition of innervated antral motility in dogs.


Effect of acetylcholine on renin secretion in salt-depleted dogs.


Transport and binding of chloroguanide-triazine by rat liver slices.


Net movements of magnesium and calcium in the rat small intestine in vivo.


Plasma pyridoxal phosphate depletion by the carcinostatic procarbazine.


Distribution of radioactivity in different tissues of pigs after 3H-hydrocortisone injection.


The effect of arvin upon cardiac function.


Isolation of gonadotropin from human term placenta.


Analysis of dextran- and methylated albumin-induced hypersensitivity by mouse paw swelling.


Studies on thymic humoral factor prepared from guinea pigs: the influence of dietary vitamin C.


The effect of glucagon on Brunner's gland secretion in dogs.


Folic acid conjugase: inhibition by unconjugated dihydroxy bile acids.


Heidenhain pouch response to antral stimulation before and after antral denervation in dogs.


On relationships between induction of liver cancer with azo dyes and changes in nuclear RNA metabolism during carcinogenesis.


Failure of growth hormone alone to potentiate epinephrine-induced lipolysis.


Induction of ovulation in adult rats with follicle stimulating hormone.


Extraction of plasminogen activator from canine vascular segments in situ.


Pathogenesis of experimental cholera: choleragen-induced rat foot edema; a method of screening anticholera drugs.


Migration of mouse lymphocytes in vitro from capillary tube cultures.


Metabolic effects of progesterone in the dog.


The binding of calcium to phospholipid-protein complexes.


Response of the human red cell to muscular activity.


Effects of benziodarone on the metabolism and biliary excretion of sulfobromophthalein and related dyes.


Rate of elimination of dimethylsulfoxide from tissues of euthermic and hypothermic rats.


Oncogenic evaluation in hamsters of human picorna-, paramyxo-, and herpesviruses.


Stimulatory effect of polynucleotides on short term leukocyte cultures.


Glucose utilization by the working rat heart.


Failure to demonstrate leukocyte migration inhibition in human tuberculin hypersensitivity.


A comparison of some biochemical properties of dissociated liver cells and of slices.


Effects of ethyl-alpha-p-chlorophenoxybutyrate (CPIB) on total cholesterol concentrations of rat aorta.


Increased hepatic microsomal activity induced by spironolactone and other steroids.


Radiation produced aggregation in crystalline preparations of ribonuclease, lysozyme, and trypsin.


Effect of selected antibiotics on prothrombin time of rats and the relationship to coumarin anticoagulants.


Hypophyseal nucleic acids: castration and thiouracil.


Nucleic acid content of rat mammary gland nucleic during pregnancy, lactation, and involution.


Strain and sex differences in renin content of rat kidneys.


Effect of gastrin on the in vivo incorporation of 14C-leucine into protein of the digestive tract.


The zeiss-Nomarski differential interference equipment for transmitted-light microscopy.


The pattern of serum triglyceride fatty acids in Laennec's cirrhosis.


Gastric secretion of acid in res- ponse to right and left atrial infusion of gastrin.


Cirrhosis and diabetes. I. Increased incidence of diabetes in patients with Laennec's cirrhosis.


Neuro-endocrine influences on human gastric secretion. I. Gastric acid and plasma cortisol responses to induced hypoglycemia.


The effect of secretin, gastrin-pentapeptide, and histamine on gastric acid and hepatic bile secretion in man.


Intestinal structure and function in neoplastic disease.


Toxic megacolon in pregnancy.

Toxic megacolon in pregnancy.


Leiomyoma of the ileum presenting as perforated viscus. Report of a case.


Ischemic dilatation of the colon.

Ischemic dilatation of the colon.


Response of giant duodenal ulcer to medical therapy. Report of a case.


Diazepam as an induction agent.

Diazepam as an induction agent.


The personal Centripeter--a particle size-selective personal air sampler.


A gravimetric dust sampling instrument (SIMPEDS): preliminary underground trials.


Determination of bis(tributyltin)oxide in air by atomic absorption spectroscopy or pyrolysis gas chromatography.


The acute toxicity and skin irritant properties of 1,2,4-trichlorobenzene.


Respiratory symptoms and pulmonary function in welders.


A screening programme for personnel exposed to laser radiation.


A legal action for noise deafness.

A legal action for noise deafness.


An appraisal of the methods of urinary diversion.


A physiological study of the isolated spleen.


Recent advances in the prevention of dental caries.


Pathology of chickens experimentally inoculated or contact-infected with an arthritis-producing virus.


A large portable isolation cabinet for poultry-disease research.


Studies on acute Marek's disease. XII. Detection of antibodies with a tannic acid indirect hemagglutination test.


Pathologic features of experimental sodium chloride poisoning in chicks.


Effect of avian encephalomyelitis vaccination on condemnation rates of broilers for Marek's disease.


Interdependence between promitochondrial and cytoplasmic protein synthesis during respiratory adaptation in baker's yeast.


Measurement of viscosity in living cells by a fluorescence method.


A preliminary study of the nucleophilic competition in beta-galactosidase catalyzed reactions.


Stimulation and inhibition by puromycin of cell-free amino acid incorporation.


Peptide sequencing by low resolution mass spectrometry. I. The use of acetylacetonyl derivatives to identify N-terminal residues.


Poly 2'-O-methylcytidylic acid and the role of the 2'-hydroxyl in polynucleotide structure.


Separation of haem incorporation from protein synthesis in liver microsomes.


Polyamines and protein synthesis. IV. Stimulation of aminoacyl transfer RNA formation by polyamines.


Active acetyl CoA carboxylase from livers of rats fed carbohydrate.


Ribulose diphosphate carboxylase. I. A factor involved in light activation of the enzyme.


Conformation of 5-bromo-uracil-arabinofuranoside.


Effects of dihydrotestosterone on the synthesis of nucleic acid and ATP in prostatic nuclei.


Protein synthesis by yeast promitochondria in vivo.


An improved, totally automated antibiotic bioassay machine.


Automatic electrode selection device for monitoring pH.


Solubility of endotoxin and stability of its biological activity in organic liquids.


The influence of growth conditions on the composition of some cell wall components of Aerobacter aerogenes.


Continuous phased culture--a technique for growing, analyzing, and using microbial cells.


Cell growth and population activity of Saccharomyces cerevisiae in two-stage continuous cultivation.


Effect of total illumination upon continuous Chlorella production in a high intensity light system.


Homogeneous cultivation of animal cells for the production of virus and virus products.


Character formation.

Character formation.


The scientific paper as artefact.

The scientific paper as artefact.


Recovery of biological materials through ultrafiltration.


Hysteria--multiple manifestations of semantic confusion.


Hysterical personality and conversion: theoretical aspects.


Psychoanalytic nosology and hysteria. A discussion of Dr. R. A. Cleghorn's paper, "Hysterical personality and conversion: theoretical aspects".


Psychogenic regional sensory and motor disorders alias hysteria.


Psychodynamics of the survivor syndrome.


A case of obsessive neurosis treated by aversion relief.


Treatment of a schizophrenic speech disorder by operant conditioning in play therapy.


Chronic perchlorethylene poisoning.

Chronic perchlorethylene poisoning.


Pulmonary disability in the Klippel-Feil syndrome. A study of two siblings.


Post-traumatic degenerative arthrosis in the manubriosternal joint.


Analysis of the pitching arm of the professional baseball pitcher.


Unusual distribution of the median nerve at the wrist. A case report.


Limitations of the use of metallic prosthesis in the rheumatoid hand.


Trochanteric fractures of the femur. Treatment with a strong nail and early weight-bearing.


A computers system for respiratory parameters.


Dependency estimation of two point processes using modified analyser of physiological data.


Computer dissection of peripheral nerve bundle activity.


Muscle relationships in functional fascia. A preliminary study.


A computer program for metabolism studies of labelled drugs.


Evaluation of rapid-cure acrylic compound for prosthesis stabilization.


A mathematical approach to medical diagnosis: application of polycythemic states utilizing clinical findings with values continuously distributed.


A practical automatic data acquisition system for stopped-flow spectrophotometry.


Cementoma of long bones. An extragnathic odontogenic tumor.


Experimental study of chymopapain in cats.


Clinical significance of serum amylase activity in the dog.


Calcium homeostasis--calcium transport--parathyroid action. The effects of parathyroid hormone on the movement of calcium between bone and fluid.


Observations on membranes of Mycoplasma laidlawii strain B. The cytoplasmic membrane of Mycoplasma laidlawii strain B is solubilized by anionic and nonionic detergents, succinylation, phospholipase A, alkaline phosphatase, trypsin, and chymotrypsin. Cationic detergents are without effect, as are chelating agents, even in the presence of high concentrations of monovalent cation. The detergent-solubilized membrane exhibits one peak in the analytical ultracentrifuge, but the sedimentation coefficient is dependent upon concentration of detergent. Simple dialysis does not remove all of the sodium dodecylsulfate except from lipid-depleted membrane particles. Membranes bind sodium dodecylsulfate but acetone powders of membranes do not. Sulfated alcohols with chain lengths of C(14) and C(16) are more tightly bound than dodecylsulfate. A constant amount of di- and trivalent cation is bound by the membrane upon aggregation. Only a portion of this cation is removable with chelating agents. No chelating agent is bound by these aggregates. A portion of the lipid-depleted membrane particles is solubilized by negatively charged lipids and detergents, giving rise to aggregates in the presence of divalent cation. Fractionations of detergent-solubilized membranes by preparative gel electrophoresis and ammonium sulfate were inconclusive. Density gradient centrifugation of succinylated membranes yielded at least five fractions which exhibited homogeneity by ultracentrifugation. Analytical gel electrophoresis of these fractions demonstrated heterogeneity. The composition of these five fractions suggested separation of protein from lipid.


Evaluation of the lumbar spine by diskography and its use in selection of proper treatment of the herniated disk syndrome.


Evidence against necessary phosphorylation during hexose transport in Aspergillus nidulans. The transport of 2-deoxy-d-glucose, a nonmetabolizable glucose analogue, into Aspergillus nidulans against a concentration gradient does not appear to require phosphorylation, despite the high levels of sugar phosphates accumulated rapidly within the cell. Two other deoxy analogues of d-glucose, 6-deoxy-d-glucose and 1,5-anhydro-d-glucitol (1-deoxy-d-glucose), although they lack the C-6 and the C-1 hydroxyl groups, respectively, and thus cannot be phosphorylated in those positions, still competitively inhibit the entry of 2-deoxy-d-glucose. Moreover, 6-deoxy-d-glucose can be concentrated against a gradient within the cell without the accumulation of 6-deoxy-d-glucose-phosphate. d-Galactose shows an intracellular ratio of free to phosphorylated sugar similar to that found for 2-deoxy-d-glucose in cells that have galactokinase, but no sugar phosphates are found in a galactokinaseless mutant strain. These data suggest that intracellular kinases are responsible for the sugar phosphate pool; and indeed, a kinase capable of phosphorylating 2-deoxy-d-glucose has been demonstrated. Finally, experiments on the kinetics of labeling of intracellular free sugar and sugar phosphate pools with (14)C-2-deoxy-d-glucose show that radioactivity appears first in the free sugar pool and after a delay enters the sugar phosphate pool.


Method for fingerprinting yeast cell wall mannans. Controlled acetolysis of yeast mannans yields mixtures of oligosaccharides with (1-->2) and (1-->3) linkages between the mannose units, whereas the less stable (1-->6) linkages of the polysaccharide backbone are cleaved. The "fingerprints," obtained by gel filtration of the oligosaccharide mixtures, can be used to distinguish between the different yeast mannans. The general method may be useful for determining the taxonomy of yeasts and for making correlations between immunochemical reactivity and mannan structure.


Lateral diskograms and chemonucleolysis in the treatment of ruptured or deteriorated lumbar disks.


Anatomy of the intervertebral disk.

Anatomy of the intervertebral disk.


Lateral approach for lumbar diskogram and chemonucleolysis.


Metabolism of Bacillus thuringiensis in relation to spore and crystal formation. A general pattern of metabolism was determined for Bacillus thuringiensis grown in a glucose-yeast extract-salts medium. The pattern did not differ significantly from that of B. cereus grown in a similar medium. Acetic acid produced from glucose during exponential growth was further catabolized in the early sporulation phase of growth, at which time the specific activity of aconitate hydratase increased markedly. Fluoroacetate and alpha-picolinate prevented the removal of accumulated acid, and the resulting low pH inhibited spore and crystal synthesis. Neither crystal-related antigens nor insect toxicity was shown by cells whose crystal synthesis was inhibited in this way. alpha-Picolinate prevented the normal increase in specific activity of aconitate hydratase without inhibiting exponential growth. It also inhibited aconitate hydratase in vitro, but only if preincubated with the enzyme. alpha-Picolinate did not inhibit the increase in specific activity of aconitate hydratase or spore and crystal synthesis in a medium buffered near neutrality. Chloramphenicol and actinomycin D inhibited crystal enlargement and sporulation when added to cells in which small crystals had already begun to form. Typical messenger ribonucleic acid-dependent protein synthesis, rather than the type associated with peptide antibiotic synthesis, is thus indicated for the synthesis of crystal peptide subunits.


Protoplasts obtained from Candida tropicalis grown on alkanes. A method for the preparation of protoplasts from Candida tropicalis cultivated on n-tetradecane is described. This essentially consists of replacing the mannitol-sorbitol solution of the classical helicase technique by 1 m magnesium sulfate and lowering the pH to 4.1 during incubation in the presence of helicase. The protoplasts thus prepared behave like intact cells and are capable of consuming oxygen in the presence of n-tetradecane, n-decane, 1-decanol, and glucose.


Yersinia philomiragia sp. n., a new member of the Pasteurella group of bacteria, naturally pathogenic for the muskrat (Ondatra zibethica). A bacterium experimentally pathogenic for muskrats (Ondatra zibethica), white mice, mountain voles (Microtus montanus), and deer mice (Peromyscus maniculatus) was isolated from the tissues of a sick muskrat captured on the Bear River Migratory Bird Refuge (Brigham City, Utah) and from four surface water samples collected within 15 miles of that point. In culture, the cells are chiefly coccoid, but in the tissues of muskrats and voles they resemble the bizarre forms of Yersinia pestis, except for their smaller size. The characteristics of the organism are described and the name Yersinia philomiragia sp. n. is proposed.


Effect of antilymphocyte serum on animals experimentally infected with Histoplasma capsulatum or Cryptococcus neoformans. The anti-mouse and anti-guinea pig antilymphocyte sera (ALS) prepared for this study were shown to contain cytoxic and leucoagglutinating antibodies, and were capable of producing severe lymphopenia in these animals. Guinea pigs treated weekly with ALS were more susceptible to development of fatal infection when inoculated with Histoplasma capsulatum. No fatalities occurred in guinea pigs infected with equal doses of H. capsulatum but treated with normal rabbit serum (NRS) or saline. The time necessary to reach 50% fatality in mice infected with Cryptococcus neoformans was greatly reduced by pretreatment with ALS in comparison with infected controls treated with NRS or saline. When low dosages were used (0.1 ld(50)), the effect was even more pronounced. Spleen homogenates from mice infected with equal dosages of H. capsulatum and treated with ALS or NRS were cultured. More than 150 times as many organisms were present in the spleens of the ALS-treated group. Similar results were obtained from culturing the lungs and liver. Delayed hypersensitive skin reactions were radically decreased or abrogated in H. capsulatum-infected guinea pigs inoculated intraperitoneally with ALS 12 hr before skin testing with histoplasmin. When ALS was given weekly, the influence on skin reactivity was less notable. Given intradermally, ALS was shown to inhibit the delayed reaction to histoplasmin within a radius of 40 mm.


Isocitrate dehydrogenase and glutamate synthesis in Acetobacter suboxydans. Acetobacter suboxydans is an obligate aerobe for which an operative tricarboxylic acid cycle has not been demonstrated. Glutamate synthesis has been reported to occur by mechanisms other than those utilizing isocitrate dehydrogenase, a tricarboxylic acid cycle enzyme not previously detected in this organism. We have recovered alpha-ketoglutarate and glutamate from a system containing citrate, nicotinamide adenine dinucleotide (NAD), a divalent cation, pyridoxal phosphate, an amino donor, and dialyzed, cell-free extract. Aconitase activity was readily detected in these extracts, but isocitrate dehydrogenase activity, measured by NAD reduction, was masked by a cyanide-resistant, particulate, reduced NAD oxidase. Isocitrate dehydrogenase activity could be demonstrated after centrifuging the extracts at 150,000 x g for 3 hr and treating the supernatant fluid with 2-heptyl-4-hydroxyquinoline N-oxide. It is concluded that A. suboxydans can utilize the conventional tricarboxylic acid cycle enzymes to convert citrate to alpha-ketoglutarate which can then undergo a transamination to glutamate.


Purification and characterization of beta-glucosidase of Alcaligenes faecalis. A cellobiose-utilizing bacterium isolated from sugar cane bagasse and identified as a strain of Alcaligenes faecalis (ATCC 21400) produced an inducible beta-glucoside-splitting enzyme. The enzyme was purified by a series of streptomycin and ammonium sulfate fractionations and by Sephadex and diethylaminoethyl column chromatography. The final preparation was purified 130-fold, with a recovery of about 10% of the initial enzyme activity. The enzyme had a wide pH range, with optimal activity at pH 6.0 to 7.0. The enzyme was stable in solution at pH 6.5 to 7.8 when kept at 30 C for 2 hr, but it was destroyed by temperatures above 55 C. At 58 and 60 C, the time required to inactivate 90% of the initial activity was 16 and 6.5 min, respectively. An activation energy of 9,500 cal/mole and a K(m) of 1.25 x 10(-4)m were obtained by using p-nitrophenyl beta-glucoside as a substrate. The K(i) value and hydrolysis of cellobiose by the enzyme indicated a high affinity of the enzyme for the cellobiose. The enzyme had its specificity on beta-glucosidic linkage and the rate of hydrolisis of glucosides depended upon the nature of the aglycon moiety. The inactivation studies showed the presence of sulfhydryl groups in the enzyme. The activity of the enzyme was easily destroyed by the Cu(++) and Hg(++) ions. The Michaelis-Menton relationship and the rate of heat inactivation indicated the presence of one type of noninteracting active site in the bacterial beta-glucosidase. Molecular weight of the enzyme was estimated by gel filtration (Sephadex G-200) and sucrose density gradient, and a value of 120,000 to 160,000 was obtained.


Pyrimidine synthesis in Neurospora crassa: gene-enzyme relationships. A new series of pyrimidine-requiring mutants of Neurospora has been isolated and all enzymes involved in pyrimidine biosynthesis are represented by at least one mutant. Among these mutants is included a single isolate for a new locus, pyr-6. This mutant is deficient in dihydroorotase (DHOase) and represents the only enzymatic step in orotate synthesis for which no mutant previously had been found. This mutant, which mapped genetically on the right arm of linkage group V, is unlinked to any of the other pyrimidine mutants. The DHOase-deficient mutant is also characterized by an unexpected growth behavior. The pyr-1 locus has been specifically associated with a lack of dihydroorotate dehydrogenase (DHOdehase). Mutants isolated in this series for other pyrimidine loci have been related to previously isolated mutants by allelism, recombination, and accumulation studies.


Pyrimidine synthesis in Neurospora crassa: regulation of enzyme activities. The regulation of several enzymes involved in pyrimidine biosynthesis in Neurospora crassa has been studied. Elevation of ATCase (l-aspartate carbamoyltransferase) activity is found in all pyrimidine-requiring mutants when they are starved for uridine. DHOase (dihydroorotase) is an unstable enzyme, and it is impossible to conclude what type of regulation, if any, controls this enzyme. DHOdehase (dihydroorotate dehydrogenase) activity shows a marked elevation in uridine-starved pyr-2 cultures, a mutant blocked late in the pathway. Several mutants blocked early in the pathway show much smaller increases in DHOdehase activity and possible explanations for this are discussed. Differences in the modes of regulation of the pyrimidine biosynthetic pathways in various organisms are compared.


Fine structure of Vibrio cholerae during toxin production. The fine structural changes associated with cell growth and toxin production have been examined in Vibrio cholerae strain 569B. No morphological alterations in the cell envelope are apparent during logarithmic growth with thin-section techniques. However, internal swelling, suggesting alteration of cell envelope permeability, is evident particularly during the late logarithmic and early stationary phases of growth. Certain extracellular material demonstrable with negative-stain techniques does appear during the period of toxin production. The possible origin of this material is discussed. The effects of high temperature (37 C) and aeration on cell structure are also examined.


Electron microscopy of small cells: Mycoplasma hominis. The size, ultrastructure, and reproduction of Mycoplasma hominis species H39 were studied by electron microscopy. These are the smallest known cells.


Amino acid composition and terminal sequences of ferredoxins from two photosynthetic green bacteria. The amino acid composition of ferredoxins from Chlorobium thiosulfatophilum 8327 and Chloropseudomonas ethylicum, like C. thiosulfatophilum Tassajara, resembled ferredoxins from nonphotosynthetic anaerobes rather than Chromatium; the terminal sequences, however, more closely resembled Chromatium ferredoxin.


Effect of low pH on thiomethyl-beta-D-galactoside uptake by Streptococcus lactis. Maximal beta-galactosidase activity in Streptococcus lactis was obtained at pH 7, but the maximal rate of thiomethyl-beta-d-galactoside uptake was observed at pH 3.6 to 4. It is concluded that the decrease in beta-galactosidase activity in intact cells at lowered pH is not due to diminished transport of beta-galactoside.


Ethidium bromide resistance, a new marker on the staphylococcal penicillinase plasmid. A strain of Staphylococcus aureus resistant to ethidium bromide is described. The genetic determinants for the resistance are present on the same plasmid as the penicillinase genes.


Transfer RNA's in human leukemia.

Transfer RNA's in human leukemia.


Preparation and storage of single spores of Saccharomyces cerevisiae. A method is described for large-scale isolation and storage of single spores of Saccharomyces cerevisiae.


Recognition sites in transfer RNA.

Recognition sites in transfer RNA.


Location of the alanyl-tRNA synthetase recognition site in yeast tRNA-II-Ala.


A plea for new theory.

A plea for new theory.


A new approach to determination of the nucleotide sequence of a viral RNA.


Nucleic acids and polynucleotides.

Nucleic acids and polynucleotides.


DNA virus maturation.

DNA virus maturation.


Conformational aspects of the nucleic acid-protein recognition problem.


Form and function of protein assemblies.


Purification and isolation of active mammalian ribosomal subunits.


Comparison of multiple injections with continuous infusion of tritiated thymidine, and estimation of the cell cycle time.


DNA synthesis and mitosis in fused cells. II. HeLa-chick erythrocyte heterokaryons.


DNA synthesis and mitosis in fused cells. 3. HeLa-Ehrlich heterokaryons.


Isopropyl N-phenylcarbamate affects spindle microtubule orientation in dividing endosperm cells of Haemanthus katherinae Baker.


Regulation of mitosis. II. Interaction of isopropyl N-phenylcarbamate and melatonin.


Macromolecular physiology of plastids. VII. The effect of a brief illumination on plastids of dark-grown barley leaves.


The olfactory bulb and medial hemisphere wall of the rat-fish, Chimaera.


The accessory olfactory bulbs and the lateral telencephalic wall of the rat-fish, Chimaera.


Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb.


Fine structural studies of the main sensory trigeminal nucleus in the cat and rat.


Effect of creativity, response mode, and subject matter familiarity on achievement from programmed instruction.


Anxiety and learning to formulate hypotheses.


Leniency toward cheating in preschool children.


Process of solving analogy items.

Process of solving analogy items.


Michigan Association for Sudden Infant Death Study. The story of the birth of a new service organization.


Autopsy diagnosis of accidental hypothermia.


Abrus precatorius poisoning in mice. Pathological findings.


The antigen M1.

The antigen M1.


The agglutination of Abantu and other human erythrocytes by reagents from snails.


A screening test for antibodies using 2-mercaptoethanol.


Results of surgical decompression of affected joints in early rheumatoid arthritis.


Urinary excretion of 17-ketosteroids in congestive cardiac failure.


Epidemiology of oral carcinoma in Eastern Districts of Uttar Pradesh.


ABO blood group and secretory status in vitiligo.


Minor injuries and their management.

Minor injuries and their management.


Osteomyelitis variolosa.

Osteomyelitis variolosa.


Rupture of liver hydatid cyst into small intestine.


Myelopathy in cirrhosis.

Myelopathy in cirrhosis.


Pendred's syndrome.

Pendred's syndrome.


"Mind expanders".

"Mind expanders".


Mitochondrial oxidation of diaminobenzidine and its relationship to the cytochemical localization of tapeworm peroxidase.


The molecular configuration of pyrimidines that causes allosteric activation of uracil transport in Hymenolepis diminuta.


Developmental physiology of cestodes. V. Effects of vitamin deficient diets and host coprophagy prevention on development on Hymenolepis diminuta.


Fine structure and organization of the musculature in the miracidium of Fasciola hepatica.


Delayed skin sensitivity in schistosomiasis.


Continuous high parasitemia in mice infectedith Babesia (Nuttallia) microti.


Ancylostoma caninum burden in relationship to erythrocyte loss in dogs.


Development of gametocytes and second asexual generation stages of Eimeria auburnensis in calves.


The current helminthofauna of stray dogs and cats in Israel.


Plasmodium jefferyi: a redescription.

Plasmodium jefferyi: a redescription.


The sporogonic cycle of Plasmodium jefferyi.


Studies of the exoerythrocytic stages of simian malaria. V. Plasmodium jefferyi.


Ascaridia galli (Schrank, 1788) from the chukar partridge, Alectoris chukar (Gray), in Nevada.


Biochemical and physiological studies of certain ticks (Ixodoidea). Gonad development and gametogenesis in Argas (Persicargas) arboreus Kaiser, Hoogstraal, and Kohls (Argasidae).


Stages in the development of Choriopsoroptes kenyensis gen. et. sp. n. (Acari: Sarcoptiformes: Psoroptidae), a body mange mite from captive African buffalo, Syncerus caffer, in Kenya.


The fine structure of a human carotid body tumour.


The fine structure of fibro-adenoma of the human breast.


Renal medullary necrosis in infancy and childhood.


Ultrastructural changes in lymphocytes in lymph-nodes, spleen and thymus after sublethal and supralethal doses of x-rays.


Primary malignant meningeal melanoma associated with benign hairy naevi.


Benign solid teratoma of uterus.

Benign solid teratoma of uterus.


Juxta-intestinal cystic schistosomal granuloma.


The delayed pressor response to small doses of intravenous noradrenaline in conscious rabbits. 1. Noradrenaline, infused intravenously at low rates into conscious rabbits, can sustain a moderate elevation of blood pressure of 20-40 mm Hg. The most effective dose range is 0.1-0.5 mug.kg(-1).min(-1).2. Toxic manifestations and tachyphylaxis occur at higher infusion rates, but have also been seen at infusion rates within this range.3. The highest sustained rise of blood pressure was obtained after initially low infusion rates had been gradually increased over a period of 2-4 weeks.


A study of chemoreceptor and baroreceptor A and C-fibres in the cat carotid nerve. 1. 149 A-fibres and 52 C-fibres from the cat carotid nerve were studied in vivo with single-unit recording techniques. These units subserved chemoreceptor and baroreceptor modalities. In addition, half of the C-fibres were determined to be efferent in origin. The estimated fibre diameter spectrum for chemoreceptor and baroreceptor A-fibres is described.2. The discharge pattern of chemoreceptor A and C-fibres was characteristically irregular both at rest and during activation. However, about 5% of the chemoreceptor A-fibre population exhibited a very regular discharge pattern, even at low rates of firing.3. In comparing A and C-fibres, it was found that chemoreceptor and baroreceptor A-fibres had lower thresholds, shorter response latencies, more rapid acceleration of discharge and higher discharge frequencies than their C-fibre counterparts.4. During strong chemoreceptor or baroreceptor stimulation, interaction of the ;spontaneous' whole nerve activity with the evoked A and C-fibre compound action potentials provided a method of estimating the relative proportions of chemoreceptors and baroreceptors in the A and C-fibre populations of the carotid nerve. The A-fibre population was found to be comprised of approximately 2/3 chemoreceptors, 1/3 baroreceptors. The reverse was true for the C-fibre population, i.e. 2/3 baroreceptors, 1/3 chemoreceptors.5. A stepwise C-fibre response is described which may arise from the several C-fibres within a single Schwann cell.


Ionic, histological and vascular factors in the reaction of the sheep's parotid to high and low mineralocorticoid status. 1. The blood capillaries from the alveolar areas of the sheep's parotid gland drain into a sinusoidal portal venous system which is in close relation to the striated intralobular ducts.2. The alveoli of the gland are surrounded by a mesh of muscular processes of myoepithelial cells: there are no myoepithelial structures in relation to the ducts.3. In close relation to the alveoli are nerve fibres, some containing noradrenaline and some with cholinesterase at their cellular contact area. Stimulation of the cervical sympathetic trunk for 1-2 min (or intra-arterial injection of noradrenaline) causes expulsion from each gland of a regular amount of saliva without changing the long term appearance rate of saliva. Stimulation of the secretomotor nerve (or acetylcholine I.A.) causes an increase in saliva production.4. It is proposed that the saliva which appears due to sympathetic stimulation is expelled from the alveoli by contraction of the myoepithelial network and is little changed during its rapid transit through the duct system.5. The results indicate that the alveolar cells react to increasing aldosterone status by increasing concentration of K(+) in alveolar fluid with inverse change of Na(+) in alveolar secretion over a wide range of flow rates.6. No histological evidence of innervation of the intralobular striated ducts by sympathetic or secretomotor nerves was obtained.7. The secretory ducts appear to be the site of exchange of HCO(3) (-) and phosphate, Na(+) and K(+), and for enrichment of SCN(-) and I(-) in the alveolar fluid.8. During stimulation of the secretomotor nerve supply, the gland, whether in adrenally insufficient or in hyperaldosterone status, shows the initial transient of discharge of K(+) into saliva and blood and then maintains K(+) intake from plasma as near to output in saliva as does the gland in the replete animal with basal aldosterone status.


Changes in the composition of rabbit hind limb lymph after thermal injury. 1. Lymph was collected directly from the hind limbs of rabbits anaesthetized with pentobarbitone and from unanaesthetized rabbits before and for several days after the hind limb was injured.2. After the limb was injured with hot water at 60 degrees C for 1 min or at 80 degrees C for 15-20 sec, there was an increase in the concentration of cytoplasmic and mitochondrial enzymes in the lymph.3. As previously found in cats, it was not until cell destruction was brought about by freezing the limb solid, that there was an increase in the concentration of lysosomal enzymes in the lymph.4. In rabbits which had a cannula permanently implanted in the femoral lymphatic, it was found that the elevated enzyme levels following a 60 degrees C burn returned to normal at between 24 and 36 hr after injury.5. The increase in enzyme activities usually occurred in two phases, an initial increase during the first 4-6 hr after the burn followed by a second increase which reached a maximum between 10 and 16 hr after injury.6. Even during the second phase which corresponded with the cellular phase of injury there was no increase in lysosomal enzymes.7. The present results support the earlier conclusion that lysosomes take little or no part in the tissue reaction to thermal injury except in the later scavenging processes after cell break-down.


Influence of prehydration on the changes in renal tissue composition induced by water diuresis in the rat. 1. The composition of renal tissue was determined in rats before and immediately after intravenous infusion of dextrose (2.5 g/100 ml.) in amounts sufficient to administer a positive fluid load of 4% body weight over 2 hr. The rats were classified into three groups, according to the preinfusion urine osmolality: hydropaenia, normal and moderately diuretic (over 2400, 800-1500 and below 800 mu-osmoles/g H(2)O, respectively).2. In non-infused rats, the steepness of the corticomedullary osmolal gradient varied, due to differences in both water and solute (sodium and urea) contents, and was related to urinary osmolality. Whereas differences in medullary and papillary solute contents occurred between all three groups, papillary water content was significantly higher only in the moderately diuretic animals.3. Dextrose infusion caused the induction of water diuresis, the lowest urinary osmolalities being produced in the previously moderately diuretic animals.4. Dextrose infusion caused a considerable reduction in the steepness of the corticomedullary osmolal gradient in all rats, particularly in the previously hydropaenic animals, due to changes in both solute (sodium and urea) and water contents. Whereas reductions in medullary and papillary solute contents occurred in all three groups, there was no further increase in papillary water content from the already high values seen in the noninfused diuretic animals.5. Thus, dextrose infusion largely abolished any previous differences in tissue water content, whereas significant, though small, differences in osmolal (particularly urea) content persisted.6. These data are discussed in terms of changes and differences in endogenous antidiuretic hormone (A.D.H.) release.7. Changes in the magnitude and direction of the urinary-papillary urea concentration difference are discussed in terms of passive transport, with probable A.D.H.-induced changes in nephron urea permeability.


Adaptation of canine pancreatic enzymes to diet composition. 1. Lipase, protease and amylase activity in canine pancreatic juice were determined during the feeding of basal, high fat, high protein and high carbohydrate diets for 3-week periods.2. The level of lipase in pancreatic juice was significantly augmented by increasing the dietary intakes of fat (P < 0.05) and carbohydrate (P < 0.05) but was not affected by increasing the protein intake.3. Protease activity was highly augmented by increasing the intake of protein (P < 0.01), was less strongly augmented by increasing carbohydrate (P < 0.10), but was not affected by the level of dietary fat ingested.4. Enzyme activities in canine pancreatic juice were modified by the nature of the diet on which the animals were maintained and the response for a given enzyme may be influenced by more than one dietary constituent.


Use of a miniature GM counter and a whole body counter in the study of potassium transport by the colon of normal, sodium-depleted and adrenalectomized rats in vivo. 1. A method is described employing a whole-body counter and a miniature GM counter placed within the lumen of the gut which can be used to study the absorption rates and kinetics of labelled substances in the mucosal epithelium in vivo. The method was applied to the study of K transport by the mucosa of the descending colon of normal, Na-depleted and adrenalectomized rats.2. The K influx rate was linearly related to luminal [K] over the range 5-80 mM. NaCN in the lumen produced a fall of electrical potential difference (p.d.) and of K secretion rate but did not reduce K influx rate. The findings were consistent with passive K influx.3. The mucosal (42)K content reached a steady value after 60-90 min of exposure to (42)K in the lumen. The value was similar in normal and adrenalectomized rats but was greater in Na-depleted rats.4. After replacement of luminal solution by a non-radioactive solution the fall of mucosal (42)K content could be described, in the majority, by a curve having two exponential components with half-times of 8-10 and 65-106 min. Approximately half of the (42)K outflow passed to the lumen. The rate constants were similar in all groups of rats.5. The results analysed on the basis of representing the mucosal K as in two compartments, indicated that the observed absorption rate could not be accounted for by transport through these compartments alone and that most of the (42)K crossed the mucosa by a fast pathway not detectable by the miniature GM counter. Most of the mucosal K was relatively inaccessible from the lumen.6. Na depletion raised the transmucosal p.d., increased the K secretion rate and appeared to increase K permeability of the mucosa but the kinetics were unaltered. Accumulation of (42)K in the mucosa was greater, suggesting that the permeability of the luminal face had increased. Adrenalectomy produced only one change, namely a reduction of K secretion rate.


A high resolution charge and mobility spectrometer for radioactive submicrometre aerosols.


An improved conductivity cell for the continuous measurement of sulphur dioxide in the atmosphere.


Fabrication of extremely fine glass micropipette electrodes.


A double-beam recording spectrodensitometer.


The distribution of portal blood flow before and after hepatic resection in dogs.


The use of metabolic inhibitors in hypothermic kidney storage.


A new self-regulating pump.

A new self-regulating pump.


The parental role. A functional-cognitive approach.


Response surface analysis of pulmonary surfactant hysteresis loops.


Trimethoprim and sulphamethoxazole in ulcerative colitis.


Combined antibacterial action in vitro of trimethoprim and sulphonamides. The in vitro nature of synergy.


Comparative studies of dihydrofolate reductase.


Assay and pharmacokinetics of trimethoprim in man and animals.


The renal handling of trimethoprim and sulphamethoxazole in man.


Toxicology of sulphonamide-trimethoprim combinations.


Effects in man of prolonged administration of trimethoprim and sulfisoxazole.


The possible scope of trimethoprim-sulphonamide treatment.


The treatment of bacteriuria in pregnant women with sulphamethoxazole and thrimethoprim. A microbiological, clinical and toxicological study.


Long-term, low-dosage, trimethoprim-sulphonamide in the control of chronic bacteriuria.


Species differences among dihydrofolate reductases as a basis for chemotherapy.


The treatment of gonorrhoea in women with sulphamethoxazole-trimethoprim.


Preliminary experience with trimethoprim and sulphamethoxazole in the treatment of purulent chronic bronchitis.


A combination of trimethoprim and sulphamethoxazole in upper respiratory infection.


Use of trimethoprim and sulphamethoxazole in tropical Africa: typhoid fever, salmonella typhi carriage and staphylococcus aureus sepsis.


Cyclamates.

Cyclamates.


The epidemiology of gastro-enteritis in infancy: I.


Mitral valve prosthesis and pregnancy withou anticoagulation therapy.


Milk of calcium renal disease.

Milk of calcium renal disease.


Control of typhoid fever by vaccination.


Paraplegics require intensive care.

Paraplegics require intensive care.


Female phenotype associated with XY karyotype: report of a case with gonadal dysgenesis.


Diabetes in South Africa.

Diabetes in South Africa.


Trimethoprim.

Trimethoprim.


A four-year survey of penetrating wounds of the neck.


Prevalence of diabetes, glycosuria and related variables among a white population in Cape Town.


A source of error in pelvic dosimetry.

A source of error in pelvic dosimetry.


Artificial fluoridation of public water supplies.


"Haemolytic" jaundice of the newborn (not Rh) in paediatric wards of general hospitals.


A comparative study of the mass spectra of delta-4(5)-, delta-5(6)-, and delta-5(10)-3-ethyleneketals of 19-norsteroids.


A simple method for the isolation of the microsomal aromatising enzyme from human placenta.


Steroids and related products. XXX. (1). Cardiotonic steroids. IV. (2). The synthesis of bufadienolides. I. (3).


Optical rotatory dispersion and circular dichroism studies of C19-steroid N-acetylglucosaminides.


Studies on the metabolism of C19 steroids in rat liver. 5. 18-Hydroxylation of 17 beta-hydroxy-C19 steroids in rat liver microsomes.


The simultaneous estimation of plasma cortisol and transcortin binding characteristics by a competitive protein binding technique.


16alpha-Hydroxycortisol metabolism in man.


Mercuric acetate oxidation of steroidal alkenes and their analogs. I. Cyclopropanes.


The addition of nitrosyl fluoride to steroid 9(11)-olefins. (1).


Progesterone synthesis in the pure trophoblasts of human choriocarcinoma.


Crystal structure of D-mann-3-heptulose monohydrate.


Synthesis of racemic sirenin, a plant sex hormone.


Cesium-137 in various Chicago foods (collection month April, 1969). HASL-210.


Inhibitory effect of DEAE-dextran on tumour growth. (2). A). Effect of DEAE-dextran in vivo on the transplantable ascites tumour JBI in C3H/A mice. B). Action of dextran sulphate administered after inoculation of DEAE-dextran inhibited tumour cells.