Responses of single units in the inferior olive to stimulation of the limb nerves, peripheral skin receptors, cerebellum, caudate nucleus and motor cortex. 1. Extra- and intracellular responses of single units in the inferior olive following stimulation of the cerebellum, limb nerves, skin receptors, the caudate nucleus and cerebral cortex have been described.2. Responses following cerebellar stimulation were assumed to be antidromic spikes when they occurred after a latency of less than 4 msec and followed stimulus frequencies greater than 220/sec. Other responses with longer latencies were thought to be transynaptic. Evidence for recurrent inhibition of the Renshaw type is given.3. Following limb nerve stimulation two types of units have been observed; units responding after a short latency and to stimulation of one limb only and units responding with a long latency following stimulation of one or more of the limbs.4. Units responding to stimulation of the limb nerve after a short latency could often be excited by hair movement and/or light touch on the pads. Other units were excited by pinching and others could not be excited by a physiological stimulus. The receptive field of these units was small and there was no evidence of fringe inhibition.5. Most units observed represented the contralateral forelimb but there was a significant number of units representing the ipsilateral limbs.6. The caudato-olivary pathway has been shown to be excitatory. Short latency limb units do not receive afferents from the caudate nucleus.7. Afferents from the motor cortex excite units in the inferior olive. A remarkable correlation of latencies of responses from both the cerebral cortex and the limbs on to individual units has been described.8. The results suggest a complex organization of neurones within the inferior olive. A possible plan of the organization of neurones is given and discussed.


A single-stage carbon-replica method and some related techniques for the analysis of the electron-microscope image.


The response of single units in the caudate nucleus to peripheral stimulation. 1. Extra- and intracellular recordings have been made of single units in the caudate nucleus of the cat, anaesthetized with alpha chloralose.2. Pentobarbitone was shown to depress the spontaneous activity and responses of units in the caudate nucleus.3. Spontaneous activity of units usually took the form of single spikes or bursts of up to four spikes occurring every 100-300 msec.4. The response to electrical stimulation of limb nerves was a burst of 1-4 spikes after a latency of about 30 msec. Convergence from all four limbs on to single units was observed. It is shown that muscle afferents do not cause these responses.5. Post stimulus histograms of spontaneously active units show, following stimulation of the limb nerves, recurring cycles of excitation and inhibition at a rate of 3-4 c/s and lasting for several seconds. It is suggested that each stimulus synchronizes the normally rhythmic spontaneous activity.6. Similar responses have been obtained following stimulation by clicks and flashes of light.7. Stimulation of the ipsilateral cerebral cortex gave excitatory and inhibitory responses similar to those described above.8. Possible mechanisms for these responses and their significance are discussed.


A device for the simultaneous dehydration of several samples for electron microscopy.


An inexpensive high intensity lamp unit for phase-contrast time-lapse cinemicrography.


Preliminary studies on the Escherichia coli uptake of the redbeard sponge (Microcionia prolifera verrill.


Effects of extracts from thymus on homograft survival in rats.


Geographic distribution of the geophilic dermatophytes in the soil.


Normal replication of DNA after repair replication in bacteria.


Fixation of antigen-antibody reaction by glutaraldehyde.


Fibrinolytically active vaginal epithelial cells.


Radiosensitization of Escherichia coli by methyl hydrazine and the effect of oxygen.


Dementia and folate deficiency.

Dementia and folate deficiency.


Ischaemic lesions of the spinal cord: an illustrated review.


Some early references to veterinary radiography and radiology.


Coccidiosis in chickens and turkeys.

Coccidiosis in chickens and turkeys.


Analysis of histophysiologic responses of the rat hypophysis to androgen treatment.


A comparison of blood trauma by various extracorporeal oxygenators.


Drug treatment of adolescent tiqueurs. A double-blind trial of Diazepam and Haloperidol.


Blood coagulation and haemostasis: a review.


Dr. Roberta Bond Nichols. An appreciation.


Extraction of lipopolysaccharides from gram-negative bacteria with dimethyl sulfoxide.


The changing cellular localization of alpha-crystallin in the lens of the chicken embryo, studied by immunofluorescence.


Some observations concerning DNA and beta-galactosidase synthesis in Escherichia coli B.


Progress in cancer surgery.

Progress in cancer surgery.


The scientific style of Breuer and Freud in the origins of psychoanalysis.


A comparison of immunofluorescence and cultural techniques for demonstration of Vibrio fetus.


Studies on the mechanism of implant-induced supernumerary limb formation in Urodeles. I. The histology of supernumerary limb formation in the adult newt, Triturus viridescens.


Studies on the mechanism of implant-induced supernumerary limb formation in Urodeles. II. The effect of heart-treatment, lyophilization and homogenization on the inductive capacity of frog kidney.


Electron microscopic immunocytochemistry: a review.


Rapid embedding of cell culture monolayers and suspensions for electron microscopy.


Experimental red cell chimerism in the heterozygote (Wvw) of the W-series mutants in the house mouse.


Applications of thin-layer chromatography in pharmaceutical analyses.


Human polymorphism.

Human polymorphism.


Social stress and cardiovascular disease. Factors involving sociocultural incongruity and change. A review of empirical findings.


End result measurements of quality of medical care.


Social stress and cardiovascular disease. Factors involving social and demographic characteristics. A review of empirical findings.


John Jacob Abel and the crystallization of insulin.


Enzymatic breakage and joining of deoxyribonucleic acid, I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage.


The interaction of actinomycin with DNA: requirement for the 2-amino group of purines.


Initiation of polyphenylalanine synthesis by N-acetylphenylalanyl-SRNA.


Morphological alteration of human embryo cells in vitro by treatment with human leukemic culture fluid.


A new change in leucine transfer RNA observed in Escherichia coli infected with bacteriophage T2.


X rays and gastroenterology.

X rays and gastroenterology.


The prevalence of Plasmodium malariae in a Baganda community in Uganda.


The Marcus Paterson collection.

The Marcus Paterson collection.


Management of the pulmonary burn.

Management of the pulmonary burn.


A technique for the light microscopy of tissues fixed for fine structure.


ANA titers in lupus erythematosus and certain chronic dermatoses.


A kinetic study on the inactivation of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase by bromopyruvate.


Release of an inhibitor of pepsin D during the activation of pepsinogen D.


Toxicity of several cyclohexyl amino acids towards Escherichia coli 9723.


Study of the glycerol kinase of Mycobacterium 607 by a colorimetric assay procedure.


Biosynthesis of fusaric acid in cultures of Fusarium oxysporum Schlecht.


The terminal groups of ribonucleate chains in each of the 16S and 23S components of Escherichia coli ribosomal RNA.


Fractionation and composition of ribonucleic acids from Schizosaccharomyces pombe.


Simplified procedures for production and isolation of the bacteriolytic proteases of Sorangium sp.


China mission accomplished.

China mission accomplished.


Recent and current trends in burn research and treatment.


The Kilborn family: a record of a Canadian family's service to medical work and education in China and Hong Kong.


A clinical study of Esucos in a mentally retarded clientele.


A clinical study of the anxiolytic effect of dixyrazine (Esucos).


The response of cultured mammalian cells to diphtheria toxin. I. Amino acid transport, accumulation, and incorporation in normal and intoxicated sensitive cells. The response to diphtheria toxin of two sensitive cell lines, KB and HeLa, was investigated. Inhibition of the incorporation of radioactively labeled amino acids into protein was the earliest detectable effect of diphtheria toxin. It was observed that, during the period of intoxication, the cell membrane was morphologically intact and retained its semi-permeable character, although it was rendered fragile and more easily disrupted by mechanical manipulations than the normal cell. The transport of amino acids continued even after intoxicated cells had ceased to synthesize protein, and the levels accumulated were equal to those of control cells. It was observed that cultural conditions, age, and handling of cells affected their response to toxin. In early log phase cells subjected to a minimum of handling before application of the toxin, the normally observed latent period preceding detectable effects was reduced to 15 min for KB cells and 30 min for HeLa cells, shorter times than previously reported. The data are consistent with the hypothesis that diphtheria toxin enters susceptible cells, possibly by pinocytosis, and there acts upon cytoplasmic sites of protein synthesis.


Cation transport in Escherichia coli. VII. Potassium requirement for phosphate uptake. When Escherichia coli K-12 is grown in media containing limiting amounts of K, growth continues normally until all the extracellular K has been consumed. Thereafter the rates of growth, glucose consumption, and oxygen consumption decrease progressively, and the cell contents of K and P fall. These changes, referred to as K limitation, are all reversed by the addition of K. By specifically altering the ionic composition of the cells it was shown that these metabolic disturbances are not due to changes in the cell content of K or Na, but are directly related to the absence of K from the extracellular medium. The cell pool of inorganic P and the uptake of PO(4) from the medium are low in K-limited cells and are immediately stimulated by the addition of K, suggesting that the primary effect of K limitation is to inhibit PO(4) uptake. All the metabolic effects of K limitation can be attributed to inhibition of PO(4) uptake. The requirement of extracellular K for PO(4) uptake may be due to a coupling between the uptake of K and PO(4).


Inactivation of Escherichia coli ribosomes by ultraviolet irradiation. I. Activity of poly U-directed polyphenylalanine synthesis.


Interaction of colicins with bacterial cells. II. Specific alteration of Escherichia coli ribosomes induced by colicin E3 in vivo.


The American Board of Pediatrics, Inc.: diplomates.


Effect of an osteogenic extract on the healing of extraction wounds.


Device for detail reproducibility tests of dental impressions.


Frameshift mutants in the histidine operon of Salmonella typhimurium.


New parameters in neonatal growth--cell number and cell size.


Potentiometric determination of dissociation constants.


Prenatal origins of mental retardation: epidemiological approach.


Testing of tablets with prolonged action. Enzyme activity during the modified half-change method.


Pharmaceutical sciences--1966. A literature review.


Jay McLean (1890-1957), discoverer of heparin.


An untoward reaction to accidental ingestion of LSD in a 5-year-old girl.


Dipyridamole in the treatment of angina pectoris. A double-blind evaluation.


Directory of otolaryngologic societies.

Directory of otolaryngologic societies.


William Crawford Gorgas (1854-1920), medical ambassador to Panama.


The effect of prostaglandins on protein and nucleic acid synthesis in a cell-free system.


Amyloidosis.

Amyloidosis.


The range of action of genes controlling radiation sensitivity in Escherichia coli.


David Porter Heap--from Carthage to the capitol city.


Congenital defects of shoulder girdle, sternum, spine and pelvis.


Cytology of cultured cells surviving actinomycin D.


Onset of DNA synthesis during the cell cycle in chemostat cultures.


On retine.

On retine.


Coenzymatic activity of homologues of pyridoxal phosphate.


Transcription of complementary strands of phage lambda-DNA in vivo and in vitro.


The structure of a DNA-RNA hybrid.

The structure of a DNA-RNA hybrid.


Demonstration of a guanosine triphosphate-dependent enzymatic binding of aminoacyl-ribonucleic acid to Escherichia coli ribosomes.


Chain initiation in a polycistronic message: sequential versus simultaneous derepression of the enzymes for histidine biosynthesis in Salmonella typhimurium.


The accuracy of lymphangiographic diagnosis in malignant lymphoma.


Translation of the genetic message. V. Effect of Mg++ and formylation of methionine in protein synthesis.


Christopher C. McClure, Sr., M.D. 1892-1967.


Replication of viral RNA. XIV. Single-stranded minus strands as template for the synthesis of viral plus strands in vitro.


Familial Mediterranean fever. A survey of 470 cases and review of the literature.


The fine structure of the ductuli efferentes of the opossum.


Aerobic heterotrophic bacterial populations of sewage and activated sludge. I. Enumeration. Agar plating media containing solely activated sludge extracts yielded, in general, higher viable counts of activated sludge bacteria than any other culture medium tested. Activated sludge extracts made from different treatment plants varied in efficacy in evoking maximal viable counts. Frequently, homologous plating, i.e., plating inocula of activated sludges on extracts made from the same activated sludges, tended to yield lower counts than the heterologous platings tried in this investigation. The counts obtained by homologous plating of activated sludge were not significantly lower and sometimes were even significantly higher than the counts obtained on standard Nutrient Agar, which had been found by previous workers to be a good medium for counting activated sludge bacteria. The higher counts obtained with activated sludge extracts set objectives for formulating reproducible or defined culture media for the enumeration of activated sludge bacteria.


Coconut and Salmonella infection.

Coconut and Salmonella infection. Raw, unprocessed coconut supports the growth of salmonellae as well as that of other enteric bacteria, salmonellae being particularly resistant to subsequent desiccation. Original contamination is not due to carriers or to polluted water supplies, but to contact with bacteria-containing soils followed by dispersion via infected coconut milk and shells. Pasteurization of raw coconut meat in a water bath at 80 C for 8 to 10 min effectively killed such bacteria, did not injure the product, and provided a prophylactic method now widely used by the coconut industry.


Production of isoamylase by Escherichia intermedia. A culture of a coliform bacteria isolated from soil produced isoamylase when grown in peptone-maltose-salts broth. The enzyme preparation was partially purified. Its similarity with isoamylase produced by Aerobacter aerogenes was established by studying its action upon various polysaccharides. A study of the organism producing isoamylase showed that it differed from A. aerogenes in some of its physiological properties. This organism was identified as Escherichia intermedia from morphological and cultural characteristics.


Microbial destruction by low concentrations of hypochlorite and iodophor germicides in alkaline and acidified water. Hypochlorite and iodophor germicides were evaluated for their ability to destroy a variety of organisms at levels approximating those used for final sanitizing rinse for dairy and food equipment and beverage bottles (3 to 50 ppm). Test organisms included Escherichia coli, Streptococcus lactis, Lactobacillus plantarum, Pediococcus cerevisiae, and Saccharomyces cerevisiae. The hypochlorites and iodophors demonstrated approximate rates of destruction at equivalent concentrations for the bacterial species tested, except where the hypochlorite contained excess alkalinity. The hypochlorite responded more readily to a downward shift to a pH of 5.0 than did the iodophor. Excess alkalinity of the hypochlorite significantly affected its bactericidal activity. The iodophor exhibited a consistently greater rate of destruction of yeast cells than the hypochlorite. Successive treatment with low levels of iodophor (6 ppm) followed by a hypochlorite (12 to 25 ppm) resulted in a high level of destruction of all test organisms. Possibilities for employing these measures in a sanitizing rinse of bottles for maximal destruction of organisms were discussed. Among the test organisms, S. lactis showed a comparatively high resistance and was a useful organism for comparing the halogen preparations.


The physician in small plant alcoholism programs.


Survey of the U.S. Gulf Coast for the presence of Clostridium botulinum. In sediments and animals collected during warm weather months between Key West, Fla., and Brownsville, Tex., Clostridium botulinum, predominantly type E, was demonstrable. Incidence was somewhat higher in the eastern Gulf animals, but the organism was present to the southernmost limits of both Texas and Florida. Types A and F were never detected in warm weather. No bottom type or any single species seemed exclusively vulnerable. In samples collected during colder weather, the east-west incidence differential was minimized in animals but not in sediments, overall incidence was lowered, all known types were present, and type E no longer predominated. Detection by fluorescent-antibody techniques was found to be inadequate.


The carboxypeptidase nature of cathepsin A.


Existence of two malic enzymes in Escherichia coli.


Induced hypothermia following cerebral anoxia.


Hemodynamic effects of changes in arterial carbon dioxide tension during intermittent positive pressure ventilation.


Isolation of methyl-B-12 from Escherichia coli B N-5-methyl-H-4-folate-homocysteine vitamin-B-12 transmethylase.


Functional reduction of anatomical dead space in the management of acute alveolar hypoventilation.


Differences between the sedimentation characteristics of the ribonucleic acids prepared from yeast cytoplasmic ribosomes and mitochondria.


Sex hair (F-pili) mutants of E. coli.

Sex hair (F-pili) mutants of E. coli.


Interruptions in single strands of the DNA in slime mold and other organisms. The molecular weight of single-stranded DNA from the slime mold Physarum polycephalum has been determined by alkaline gradient centrifugation. The average molecular weight during DNA synthesis ( approximately 1.5 x 10(7) D) is less than that observed in nonsynthetic periods ( approximately 4 x 10(7) D). On the basis of a chromosome number of 50 per nucleus and a DNA content of 1 mumug per nucleus, we are led to conclude that at pH 12 each chromosome dissociates into 300 (single-stranded) pieces of DNA. We have also compared the sedimentation profiles of single-stranded DNA from Escherichia coli, PPLO, and T2 bacteriophage. These data support the conjecture that each bacterial chromosome can be dissociated into 10 or 12 single-stranded pieces of DNA. Dissociation of DNA into multiple pieces under our experimental conditions is best interpreted in terms of interruptions in the continuity of the DNA either by naturally occurring gaps or at alkali-labile bonds.


Premedication of children with papaveretum-hyoscine. The effect of varying dosage schemes.


Immune reaction and the lysis of corneal cells in vitro and in vivo.


Histological and serological features of experimental autoimmune thymitis in guinea-pigs.


Runting syndrome in neonatal rabbits infected with Treponema pallidum.


Escherichia coli serotypes orally. I. Induced gastroenteritis and pathological changes in neonatal calves.


A theory of the action of cancer chemotherapeutic drugs.


Escherichia coli serotypes intravenously. II. Pharmacological effects and tolerance.


Escherichia coli serotypes intravenously. 3. Pathological changes and pathogenesis.


Strontium-85 tracer method for determination of strontium-90. A review of 4 years' experience.


Cryohypophysectomy: indications, technic, and results.


Congenital malformations of the cerebrospinal axis seen in western Nigeria. The African child with "encephalocele".


Characterization of enterobacteria by starch-gel electrophoresis of glucose-6-phosphate dehydrogenase and phosphogluconate dehydrogenase. Specific activities and electrophoretic mobilities of glucose-6-phosphate dehydrogenase and phosphogluconate dehydrogenase were determined in 38 isolates of the family Enterobacteriaceae and in 10 isolates of the related Pasteurella. The deficiency of glucose-6-phosphate dehydrogenase in P. pestis was verified. Enzymes obtained from different strains of the same species exhibited an unexpected degree of heterogeneity. For example, 8 and 11 apparent variants of glucose-6-phosphate dehydrogenase and phosphogluconate dehydrogenase, respectively, were found in 14 strains of Escherichia coli. Although similar frequencies of heterogeneity were noted in 7 strains of P. pseudotuberculosis, 5 species of Shigella, and 8 species of Salmonella, differences in mobility were generally small in comparison with those observed between strains of E. coli. Values obtained for the pasteurellae, shigellae, and salmonellae, thus fell within narrow ranges that may prove typical for the genera. However, most of these ranges, as well as many values observed for single species of other genera, were overlapped by the wide range recorded for E. coli. The significance of this observation was discussed with respect to the relative age and taxonomic position of the organisms in question. The method could be used to distinguish between most wild-type strains of the same species and should thus facilitate investigations of genetic transfer and epidemiology.


Failure of bacterial endotoxin to produce the generalized Shwartzman reaction in the Syrian hamster. The ability of bacterial endotoxin to produce the generalized Shwartzman reaction (GSR) in pregnant and nonpregnant hamsters was investigated. Endotoxins prepared from Escherichia coli O127:B8, Salmonella enteritidis, and S. typhosa 0-901 did not produce the GSR in nonpregnant hamsters. Injection of lead acetate did not make the hamsters susceptible to the GSR producing effects of endotoxin. Endotoxin administered to hamsters on either or both the 14th and 15th day of the 16-day gestation period caused fetal death, but did not provoke the GSR. The immunization of hamsters with boiled suspensions of gram-negative bacteria isolated from hamster feces did not protect against the GSR produced in pregnant hamsters by the injection of the antimitotic drug colchicine late in the gestation period. It appeared that colchicine was acting to produce the GSR by a mechanism other than the release of endogenous endotoxin through the damaged intestinal wall. Ascitic fluid, amniotic fluid, and serum obtained from pregnant hamsters developing the GSR after the administration of colchicine did not provoke the GSR in other pregnant hamsters.


Decomposition of ribosomal particles in Escherichia coli treated with mitomycin C. Exposure of cells of Escherichia coli to mitomycin C (5 mug/ml) resulted in a marked change in the sedimentation profiles of the cell-free extracts, indicating a specific decomposition of ribosomal particles. When the extracts were prepared in the presence of 0.01 m Mg(++) and analyzed by sucrose density gradient centrifugations, the 100S fraction disappeared rapidly from the treated cells. The 70S ribosomes were also degraded, but more slowly, with a concomitant accumulation of a fraction having a sedimentation coefficient of about 50S. However, decomposition of the 70S ribosomes was preceded by an almost complete loss of the 50S ribosomal subunits, as revealed by sedimentation analyses in the presence of 10(-4)m Mg(++). Synthesis of the ribosomes in the treated cells was also suppressed, being demonstrated by a lower incorporation of uracil-2-(14)C into the ribosomal fractions. However, the change in the ribosomal profile in the treated cells apparently resulted from the decomposition of pre-existing ribosomes, rather than from the inhibition of the net synthesis of ribosomes. Sedimentation analyses and chromatography of the nucleic acids extracted from the treated cells indicated extensive but delayed degradation of the ribosomal ribonucleic acid (RNA), but not of the soluble RNA or deoxyribonucleic acid fractions. Altered structure of the ribosomes in the treated cells was also indicated by their lower melting temperature, broadened thermal profile, higher electrophoretic mobility, and extreme sensitivity to ribonuclease treatment, compared with normal ribosomes. The synthesis of messenger RNA was inhibited progressively with time in the treated cells.


In memoriam. Professor Bernard Zondek.

In memoriam. Professor Bernard Zondek.


Genetic basis of colicin E susceptibility in Escherichia coli. I. Isolation and properties of refractory mutants and the preliminary mapping of their mutations. Colicin E-resistant mutants were isolated in Escherichia coli K-12 which, although still apparently possessing the E receptor and adsorbing colicin, were nevertheless insensitive (refractory) to its effect. Eight phenotypic groups were obtained, but some mutants from three of these groups were all shown to map at gal, whereas a second refractory locus, giving resistance to E1 alone, mapped close to thy. It is suggested that the successful fixation of any of the three distinct colicins of group E may involve a dual role for the cell surface "receptor," the first for the binding of the protein and the second for the correct orientation of the bound molecule relative to the cytoplasmic membrane. The majority of the refractory mutants isolated may derive from changes in components concerned with the second of these receptor functions. Two groups of mutants, however, refractory to only E1 or E2, probably reflect changes in the intracellular transmission systems which specifically mediate the effects of these two colicins, the changes not allowing transmission through the cytoplasmic membrane to the respective targets of the colicins. The E1 adsorption site was shown to be distinct from that for E2 and E3, indicating an early separation of the colicin E transmission systems.


Comparative study of the events associated with colicin induction. Colicinogenic factors ColI and ColV, which have been shown to behave as sex factors, could not be induced with mitomycin C. In contrast, the ColE(1), ColE(2), and ColE(3) factors, which do not exhibit any fertility factor characteristics, are inducible by this agent. The induced production of colicins E(1), E(2), and E(3) was accompanied by a loss in viability at a concentration of mitomycin C which was bacteriostatic to noncolicinogenic cells or to cells carrying the ColV or ColI factors. The loss in viability accompanying the mitomycin C induction of the ColE(1), ColE(2), or ColE(3) factors also occurred when colicin synthesis was blocked by chloramphenicol or amino acid starvation. However, chloramphenicol was able to block the loss of viability of a recipient cell after mitomycin C induction of a newly acquired Col factor if the antibiotic was present throughout the mating period. No detectable internal colicin or colicin precursor could be demonstrated during the lag period prior to the appearance of colicin outside the cell 20 to 30 min after the addition of mitomycin C. If chloramphenicol was present during the lag period following the addition of mitomycin C, colicin synthesis began immediately after the removal of these antibiotics. The synthesis of tryptophan synthetase and induced beta-galactosidase proceeded normally throughout the lag period and well into the period of colicin production. Regulation of beta-galactosidase synthesis did not seem to be profoundly affected during the lag period subsequent to mitomycin C addition. Induced colicin synthesis, like bacterial or induced prophage protein synthesis, was subject to inhibition by virulent phage infection.


Effect of Rec mutations on the activity of colicinogenic factors. The effect of two Rec(-) mutations (AB2463 and JC1553) on the ability of a cell to accept, maintain, and express the colicinogenic factors ColE(1), ColE(2), and ColV was examined in Escherichia coli. These mutations had no observable effect on the colicinogenic properties of the ColV factor, but prevented the spontaneous and induced production of colicins E(1) and E(2) which are determined by the ColE(1) and ColE(2) factors, respectively. The two Rec(-) mutations had no apparent effect on the ability of the cells to acquire, maintain, or transfer the ColE(1) and ColE(2) factors. These mutations did not affect the expression of immunity by any of the three Col factors. ColE(1) and ColE(2) were also shown to be indirectly induced by mating F(-) cells carrying these Col factors with ultraviolet-irradiated, non-colicinogenic, Hfr and F(+) cells. Indirect induction of colicin production occurred when either an irradiated F(+) Rec(+) or F(+) Rec(-) strain was employed as the donor strain.


Biosynthesis of androgens from progesterone by minute amounts of rat and human testicular tissue in vitro.


Growth inhibition by hexoses of a temperature-sensitive thiazoleless mutant of Salmonella typhimurium. A Salmonella typhimurium mutant showing impairment in the utilization of hexoses was isolated after treatment with N-methyl-N'-nitro-N-nitrosoguanidine. At 30 C, it grew with hexoses (glucose, fructose, galactose, mannitol), glycerol, succinate, or acid-hydrolyzed casein. At 37 C, it failed to grow with any of the hexoses. Enzymatic determinations demonstrated, however, that the enzymes of the glycolytic pathway (up to the formation of triose phosphates) were present and active at 25 and 32 C. At 42 C, the mutant did not grow with any of the carbon sources used. At both 37 and 42 C, the mutant grew perfectly well with hexoses if yeast extract was present. The metabolite required for growth was thiamine or, specifically, its thiazole moiety. If glucose was added to a culture growing in glycerol, at 37 C, growth was inhibited. This inhibition was relieved by the addition of thiamine or thiazole. Thus, at 37 C and only in the presence of hexoses, the mutant manifests a requirement for thiazole. This auxotrophy is absolute at 42 C. These data indicate that, in this mutant, some derivative of hexoses inhibits the synthesis of thiazole, and that this inhibition is also dependent on the temperature of incubation. The position in the bacterial chromosome of the genetic locus of this lesion (thz(-)) was determined by conjugation and found to coincide with the only thiamine (thi) locus so far reported.


Inhibition of Escherichia coli B by homoarginine. Homoarginine inhibits the growth of Escherichia coli B, but not of E. coli K-12. These two strains also differ in regard to repressibility of the arginine-forming enzymes. In K-12, arginine acts as a repressor whereas in B it does not. The latter difference is determined by different alleles of a regulator gene, arg R. In K-12 x B crosses, it was shown that the genetic determinant for homoarginine sensitivity is closely linked to or identical with arg R. Homoarginine-resistant mutants of B were isolated. The biochemical mechanism of homoarginine inhibition is not known. However, whether or not a strain is sensitive to homoarginine seems to depend on the intracellular level of arginine. In B this level is relatively low and inflexible as a result of the action of a repressor whose formation is determined by the B-specific allele of arg R.


Genetic mapping of a mutation in Escherichia coli showing reduced activity of thymidine phosphorylase.


Shortening the ischemic time in cadaveric human renal transplantation.


Evaluation of observer performance using televised stereofluoroscopy.


Reports of clinical studies of psychiatric drugs.


Further evidence for positive control of the L-arabinose system by gene araC.


Specific binding of sRNA to ribosomes during polypeptide synthesis and the nature of peptidyl sRNA.


Ribosomes from a streptomycin-dependent strain of Escherichia coli.


On the mechanism of amino acid control of ribonucleic acid biosynthesis.


Rights, responsibilities, and protection of patients in human studies.


Medical and biological research on human beings.


A new circular dichroic band in nucleic acids and ribosomes.


Decryptification of RNA polymerase in whole cells of Escherichia coli.


Responsibility for the ethical conduct of clinical research.


The influence of deletions on polarity.

The influence of deletions on polarity.


Institutional controls in the handling and use of investigational drugs.


Involvement of N-formylmethionine in initiation of protein synthesis in cell-free extracts of Euglena gracilis.


Preprosthetic surgery: a scheme for its effective employment.


Routine blood pressure measurement in psychiatric research.


Isergonic relations and their significance for catalysis.


A clinical evaluation of chlorphenoxamine with caffeine in the treatment of Parkinson's disease, including a comparison with methixene.


Antibacterial and antifungal properties of beta-naphthol derivatives. VI.


Consent for use of investigational new drugs on humans.


Our senior educators (Burtrum C. Schiele).


Modern trends in the treatment of spina bifida. Early closure in spina bifida: results and problems.


Modern trends in the treatment of spina bifida. Methods of assessment and their relation to treatment by early closure.


Principles and problems of rehabilitation in spina bifida.


Amine secreting tumors. The amine content of mast cells.


Megarectum in the older child.

Megarectum in the older child.


Epoxy embedding of thin-layer material in commercially available vinyl cups for light and electron microscopy.


Differentiation of mast cells in the subcutaneous connective tissue of rat embryos.


Stability of horse dander extracts.

Stability of horse dander extracts.


Systemic insecticides in trees.

Systemic insecticides in trees.


Temperature effects on embryonic development in insects.


Mode of action of insecticide synergists.


Consequences of insecticide use on nontarget organisms.


A critical review of Bacillus thuringiensis var. thuringiensis Berliner and other crystalliferous bacteria.


Trans-stadial and transovarial development of disease agents in arthropods.


Ticks in relation to human diseases caused by Rickettsia species.


Recent fundamental work on tsetse flies.


Gut absorption.

Gut absorption.


Effect of intestinal exclusion in Escherichia coli endotoxin shock.


Recombination: damage and repair of bacteriophage genome.


Alteration of respiratory particles by mutation in Escherichia coli K 12.


Isolation and preliminary characterization of T4 mutants with nonglucosylated DNA.


Partial purification and antilymphoma activity of Serratia marcescens L-asparaginase.


Stereochemical investigation of the active center of pepsin using a new inactivator.


Association of temperate phage P2 with the production of histidine negative segregants by Escherichia coli.


Microbial metabolism of amino ketones. L-1-aminopropan-2-ol dehydrogenase and L-threonine dehydrogenase in Escherichia coli. 1. A wide range of intermediary metabolites and substrate analogues have no effect on the oxidation of dl-1-aminopropan-2-ol to aminoacetone by washed-cell suspensions of Escherichia coli. Only dl-2-hydroxy-2-phenylethylamine, dl-1,3-diaminopropan-2-ol, dl-serine and l-1-(3,4-dihydroxyphenyl)-2-aminoethanol act as inhibitors. 2. Dialysed cell-free extracts of E. coli exhibit an NAD(+)-dependent dl-1-aminopropan-2-ol-dehydrogenase activity of approx. 8mmumoles of aminoacetone formed/mg. of protein/min. at the pH optimum of approx. 10. The K(m) values for the coenzyme and dl-amino alcohol are approx. 0.4 and 10.0mm respectively. A smaller peak of activity occurs at pH7.0-7.2, the K(m) for NAD(+) at pH7 being approx. 0.05mm. 3. Enzyme activity in cell-free extracts is inhibited by dl-2-hydroxy-2-phenylethylamine, dl-1-aminopropane-2,3-diol and dl-serine. dl-Phenylserine and dl-1-aminobutan-2-ol are oxidized to compounds reacting as amino ketones. 4. In fresh cell-free extracts l(+)-1-aminopropan-2-ol preparations are oxidized more rapidly than racemic or laevo-rotatory material, the d(-)-enantiomorph appearing to act as a competitive inhibitor. The K(m) for l(+)-1-aminopropan-2-ol appears to be approx. 1.5mm when highly resolved substrate preparations are used, either in the free base form or as the l(+)-tartrate salt. 5. l(+)-1-Aminopropan-2-ol dehydrogenase is a labile enzyme, and in appropriately treated extracts activity towards the d-enantiomorph is detectable and relatively higher than that towards the l-enantiomorph. 6. Optimum activity of l-threonine-dehydrogenase in cell-free extracts is exhibited at pH9.6 in the presence of NAD(+). The K(m) values for coenzyme and amino acid substrate are approx. 0.08 and 5.0mm respectively. This enzyme is distinct from 1-aminopropan-2-ol dehydrogenases on the basis of kinetic evidence, and the separation of activities by gel filtration. 7. Both l-threonine and dl-1-aminopropan-2-ol dehydrogenases are markedly inhibited by 8-hydroxyquinoline and p-chloromercuribenzoate, but only slightly by other chelating and thiol reagents. 8. E. coli is incapable of growth on simple synthetic media, containing a variety of carbon sources, when dl-1-aminopropan-2-ol is supplied as the sole source of nitrogen. It appears unlikely that the micro-organism can deaminate aminoacetone. 9. The metabolic roles of l-threonine dehydrogenase, aminoacetone and 1-aminopropan-2-ol dehydrogenases are discussed.


Prefabricated attachments for complete overlay dentures.


Protein synthesis in tomato-fruit locule tissue. Incorporation of amino acids into protein by aseptic cell-free systems. 1. Osmotically disrupted protoplasts and isolated plastids from tomato-fruit locule tissue were found capable of incorporating (14)C-labelled amino acids under aseptic conditions into an exhaustively washed trichloroacetic acid-insoluble protein fraction. 2. The disrupted protoplast system incorporated 20-45mumumoles of amino acid/mg. of protein in 10min. The isolated plastid system incorporated 10-20mumumoles of amino acid/mg. of protein; 40-150mumug. of carbon/mg. of protein was incorporated in 10min. from (14)C-labelled amino acid mixture. 3. Incorporation is stimulated by added ATP in the dark, but no added ATP is required when the system is illuminated. The cell-free plastid system is to some extent self-sufficient and does not normally require an added supernatant fraction or unlabelled amino acids. 4. Amino acid incorporation by plastids is inhibited by chloramphenicol, puromycin, actinomycin D, ribonuclease and deoxyribonuclease. It is suggested that the mechanism of protein synthesis in the cell-free plastids, and in the tissue generally, is basically the same as established for bacteria. Ribosomes and highspeed supernatant from this tissue were to some extent interchangeable with Escherichia coli ribosomes and supernatant in cell-free incubations. 5. Incorporation of amino acids by isolated plastids was stimulated by indol-3-ylacetic acid and kinetin, and, whereas incorporation normally proceeds for only 10-20min., the time-course was extended in the presence of these growth substances. It is suggested that hormones may be involved in the regulation of protein synthesis in plants.


Rapid demineralisation for microscopy of tooth enamel and associated structures.


The formation and distribution of ribosomes during hormone-induced growth and development.


Thomas Greenhalgh Battersby, F.D.S.

Thomas Greenhalgh Battersby, F.D.S.


Surgeon Rear-Admiral (D) Charles Joseph Finnigan, C.B., L.D.S.


Studies on the effect of gentamicin on Proteus vulgaris.


The differential diagnosis of neuromuscular weakness in infancy and childhood. II. The dystrophic myopathies.


Fetal electrocardiography: a survey of the literature.


The incidence of vitamin-C deficiency in meningomyelocele.


65th birthday of professor Dr. K. Zlábek.


The development of the skeleton in the guinea-pig. II. The morphogenesis of the carpus in the guinea-pig (Cavia porcellus).


Phase-contrast, fluorometric and autoradiographic determination of the transport of nucleolar products.


Morphology of terminal growth cones of regenerating nerve fibres.


A contribution to the method of embedding orientated tissue for the use of electron microscopy.


Sir Archibald E. Garrod.

Sir Archibald E. Garrod.


Reversion instability of an extreme polar mutant of the galactose operon.


Management of acute exacerbations in chronic bronchitis. A clinical trial.


Use of groundnuts in the preparation of bacteriologic media. Preliminary communication.


Medium-chain triglycerides--clinical and metabolic aspects.


The American Dietetic Association, Mary C. Zahasky, president.


Reimbursement for nutrition services in home health programs under Medicare.


Salmonella typhimurium infection in dairy cows.


Ultrastructure of the spoon type synaptic endings in the nucleus vestibularis tangentialis of the chick. The fine structure of the "spoon" type synaptic endings of the chick tangential nucleus was studied with the electron microscope. These endings often measure approximately 18 micro in length by approximately 3-4 micro in width. The axoplasm of the endings contains very few synaptic vesicles, a large number of neurofilaments oriented parallel to the long axis of the nerve fiber, and microtubules and numerous mitochondria. The synaptic membrane complex shows areas of localized occlusion of the synaptic cleft with the formation of an external compound membrane. It has not been decided whether these areas have a disc shape; their length measures between 0.04 and 0.47 micro. The five-layer pattern characteristic of an external compound membrane is shown in specimens fixed with formalin-OsO(4), glutaraldehyde-acrolein-OsO(4), and acrolein KMnO(4) but it does not appear in the glutaraldehyde-OsO(4)-fixed specimens. The over-all thickness of the external compound membrane varies depending upon the fixative used. The synaptic clefts in the regions between the external compound membrane discs are widened and measure approximately 300 A. A condensation of dense material occurs in pre- and postsynaptic cytoplasms all along the synaptic membrane complex. The morphological relationships described in the spoon endings are suggestive of electrical transmission.


Morphology of rigor--shortened bovine muscle and the effect of trypsin on pre- and postrigor myofibrils. Bovine semitendinosus muscles were sampled immediately after death, after 24 hr postmortem with storage at 2 degrees , 16 degrees , or 37 degrees C, and after 312 hr postmortem with storage at 2 degrees and 16 degrees C. A biopsy technique was used to prevent shortening during glutaraldehyde fixation. Postfixation in osmium tetroxide was followed by embedding in an Epon-Araldite mixture. Bovine muscle was supercontracted after 24 hr storage at 27deg; but was only slightly contracted after storage at 16 degrees for 24 hr. Muscle held at 37 degrees for 24 hr was slightly less supercontracted than the 2 degrees muscle. Striking similarities existed between muscles stored at 16 degrees and at 2 degrees C for 312 hr. Both were slightly shortened with narrowed I bands and an area of increased density, probably due to overlap of thin filaments in the middle of the A band. Postmortem shortening was accompanied by banding-pattern changes similar to those predicted for contracting muscle by Huxley and Hanson's sliding filament model. Treatment of myofibrils with 0.05% trypsin resulted in a rapid loss of Z lines and, in supercontracted myofibrils, caused a return of the banding pattern of resting muscle.


Cytoplasmic protrusions in insect cells during mitosis in vitro.


The arginine provocative test: an aid in the diagnosis of hyposomatotropism.


The influence of communal fluoridation upon dental practice.


Studies with androsterone-3-3H,4-14C.

Studies with androsterone-3-3H,4-14C.


Thumbsucking: habit or symptom?

Thumbsucking: habit or symptom?


Breast feeding versus bottle feeding in relation to oral habits.


Ectodermal dysplasia and the Lyon hypothesis.


Amalgam onlays. A technique for restoring hypoplastic first molars with pin-reinforced amalgam.


Effective toothbrushing requires instruction.


Localized juvenile periodontosis.

Localized juvenile periodontosis.


Aggregation in vivo of dissociated cells. II. Role of developmental age in tissue reconstruction.


Suppression of feather morphogenesis in co-aggregates of skin cells from embryos of different ages.


Ernst Albert Gäumann, 1893-1963.

Ernst Albert Gäumann, 1893-1963.


Death mechanisms in airborne Escherichia coli.


Effect of isoniazid on biosynthesis in Mycobacterium tuberculosis var. bovis BCG.


The uptake and fate of isoniazid in Mycobacterium tuberculosis var. bovis BCG.


Seven sketches of one man. Dr. Harvey A. Robinson. 1917-1966.


A decade of development in the knowledge of brain mechanisms.


Changes associated with parasitism in nematodes. I. Morphology and physiology of preparasitic and parasitic larvae of Meloidogyne javanica.


The location of the restriction locus for lambda-K in Escherichia coli.


Bone sarcoma.

Bone sarcoma.


Rate of mutation of phage resistance in 2H2O medium.


Isotope effect in tunneling and its influence on mutation rates.


Locus for radiation sensitivity in Escherichia coli B3.


Teaching machines and programmed instruction: areas of application.


Experimental and correlational studies of the fear of death.


Selective attention.

Selective attention.


Arousal sweating and electrodermal phenomena.


Evaluation of an oral proteolytic enzyme in operations upon the hand.


West Virginia medicine (1876-1900).

West Virginia medicine (1876-1900).


The mechanism of hypoxaemia after laparotomy.


Mitral valve replacement with aortic heterografts in humans.


Declaration of Helsinki. Recommendations guiding doctors in clinical research. Adopted by the World Medical Association in 1964.


Members, State Medical Society of Wisconsin.


Control of bacteria in nondomestic water supplies.


Oral microbiology.

Oral microbiology.


Media and methods for isolation and enumeration of the Enterococci.


Genetics in applied microbiology.

Genetics in applied microbiology.


Crystal-forming bacteria as insect pathogens.


The ecological approach to the study of activated sludge.


Mycotoxins in feeds and foods.

Mycotoxins in feeds and foods.


The polyunsaturated fatty acids of microorganisms.


Lipid metabolism in the bacteria.

Lipid metabolism in the bacteria.


The role of lipids in blood coagulation.


Quantitative methods for the study of vitamin D.


Labeling and radiopurity of lipids.

Labeling and radiopurity of lipids.


Lipid responses to dietary carbohydrates.


Effects of catecholamines on lipid metabolism.


Effects of stereotaxic thalamotomy to intractable pain and numbness. Preliminary report.


Current status of pharmacotherapy in schizophrenia.


Clinical application of 4-hydroxybutyrate sodium and 4-butyrolactone in neuropsychiatric patients.


A polygraphic study on the effect of atropine on human nocturnal sleep.


The development of an idea. The mesh skin graft.


The prince and prophet.

The prince and prophet.


Radiosensitivity of bone marrow cells in the mouse strains with different LD50.


Roentgenographic study of the volume of the sella turcica. 3. Evaluation on the estimating method of the volume.


Generalized expectancies for internal versus external control of reinforcement.


Contributions of the intestinal microflora to the nutrition of the host.


The detection and measurement of thyrotropic substances in health and disease.


Insulin and the regulation of hepatic biosynthetic activity.


Alarm substances and alarm behavior in social insects.


International symposium on recent advances in research on vitamins K and related quinones (vitamins K, ubiquinones or coenzymes Q, plastoquinones) in honor of Professor Henrik Dam. Historical survey and introduction.


Occurrence of vitamins K and related quinones.


Syntheses of vitamins K and related compounds with special reference to labeling.


Physicochemical properties and methods of analysis of phylloquinones, menaquinones, ubiquinones, plastoquinones, menadione, and related compounds.


International symposium on recent advances in research on vitamins K and related quinones (vitamin K, ubiquinones or coenzymes Q, plastoquinones) in honor of Professor Henrik Dam. Session 1: Summary and prospects.


Phosphorylation of derivatives of the vitamin K group.


The chemistry of ubiquinone.

The chemistry of ubiquinone.


Mode of action of vitamins K in animals.


Mode of action of ubiquinones (coenzymes Q) in electron transport systems.


Mode of action of vitamin K in microorganisms.


Function of quinones in photosynthesis.

Function of quinones in photosynthesis.


International symposium on recent advances in research on vitamins K and related quinones (vitamin K, ubiquinones or coenzymes Q, plastoquinones) in honor of Professor Henrik Dam. Session 2: Summary and prospects.


Biosynthesis of ubiquinones and vitamins K in microorganisms.


Biosynthesis of ubiquinones in animals.

Biosynthesis of ubiquinones in animals.


Interrelationships between ubiquinones and vitamins and hormones.


International symposium on recent advances in research on vitamins K and related quinones (vitamin K, ubiquinone or coenzymes Q, plastoquinones) in honor of Professor Henrik Dam. Session 3: Summary and prospects.


Biological activity of the various vitamin K forms.


Antagonists of vitamin K.

Antagonists of vitamin K.


Vitamin K in animal nutrition.

Vitamin K in animal nutrition.


Some observations on the assay of anterior pituitary hormones.


Vitamin K in medical practice: pediatrics.


International symposium on recent advances in research on vitamins K and related quinones (vitamin K, ubiquinone or coenzymes Q, plastoquinones) in honor of Professor Henrik Dam. Session 4: Summary and prospects.


Vitamin K in medical practice: adults.

Vitamin K in medical practice: adults.


Denervation supersensitivity of structures innervated by the autonomic nervous system.


Control of the psychogenic factors in skin diseases.


The U.V. sensitivity of bacteria: its relation to the DNA replication cycle.


Patterns of nucleic acid and protein synthesis during modification of lethal ultraviolet lesion.


Comparison of survival of a U.V.-irradiated uracil-requiring strain of Escherichia coli B in the presence of chloramphenicol and in the absence of the essential metabolite.


The history of ancient Korean medicine.

The history of ancient Korean medicine.


List of publication from Yonsei University College of Medicine during 1966.


A phase contrast microscopic study on the induction of cellular deformation in mast cells.


Effect of prolonged heavy exercise on renal function and urinary protein excretion.


Current status of U.S. participation in the International Biological Programme.


Lawrence Oschinsky: 1921-1965.

Lawrence Oschinsky: 1921-1965.


Members of the American Orthoptic Council--1967.


Reflections on the education of George Herbert Mead.


Hatcher and intraflock transmission of Mycoplasma meleagridis.


A comparison of incubation time and temperature for the isolation of salmonella.


Amino acylaminonucleoside inhibitors of protein synthesis. The effect of amino acyl ribonucleic acid on the inhibition.


An investigation of the peptic activation of acetylated trysinogen.


Studies on the specificity of pepsin.

Studies on the specificity of pepsin.


Optical rotatory dispersion of E. coli ribosomes and their constituents.


Physiology and phylogenesis of emotional expression.


Electrical impedance and volume changes in brain during preparation for electon microscopy.


Latency of the gastric secretory response to sham feeding in the dog.


The influence of cooked and raw wheat starch on dental caries in the rat.


The production of haemorrhagic necrosis in the hamster cheek pouch by bacterial endotoxins and catecholamines.


Meinhard von Pfaundler and the history of small-for-dates infants.


Embedding in celodal-vestopal for electron microscopy. I.


The seventieth birthday of professor Dr. L. Borovanský.


A contribution to the embedding technique for electron microscopy.


J. E. Purkynĕ's microscope preparations drawn by E. Haeckel.


The utilization of celodal and resonal in histological technique.


Senator asks legislation to spur hospitals' building of ECF's.


Vitamin B12 levels in whole blood, plasma, and blood cells in transplantable rat leukaemias.


Further studies on the membrane immunofluorescence reaction of Burkitt lymphoma cells.


A review of some major works in Soviet hypnotherapy.


Ultrastructural, cytochemical, and microgasometric studies of acetylcholinesterase in isolated neurons of the frog.


The Army Dental Service in Vietnam.

The Army Dental Service in Vietnam.


Thomas Hodgkin (1798-1866).

Thomas Hodgkin (1798-1866).


Lipid metabolism in xanthomas: an approach to the study of atherosclerosis.


Effect of some metabolic inhibitors on plaque formation in Jerne plates.


Polarography and its biological applications.


Hemochromatosis.

Hemochromatosis.


Investigation of the effect of old tuberculin and BCG on experimental cholesterol atherosclerosis in the rabbit.


Catecholamines in brown fat.

Catecholamines in brown fat.


Subtraction in radiology.

Subtraction in radiology.


Atromid and platelet adhesiveness in multiple sclerosis.


Virus-induced hydrocephalus: development of aqueductal stenosis in hamsters after mumps infection. Hydrocephalus developed as a sequela of mumps virus infections of suckling hamsters. The initial infection after intracerebral inoculation was limited largely to ependymal cells lining the ventricles. This infection was clinically inapparent but later resulted in a noninflammatory stenosis or occlusion of the aqueduct of Sylvius.


Cybernetic aspects of medical history.

Cybernetic aspects of medical history.


Two types of radiation-sensitive mutant in yeast.


100th anniversary of...an unbeatable combination.


A simplified procedure for the calculation of cardiac output from dye dilution curves.


Reconstituted collagen sutures in corneal surgery. An experimental and clinical evaluation.


Transferable resistance factors with mutator effect in Salmonella typhi.


Effect of N-methyl-N'-nitro-N-nitrosoguanidine on the F factor of Escherichia coli.


Differential effects of acriflavine and caffeine on various ultraviolet-irradiated Escherichia coli strains and T1 phage.


Effect of azathioprine (imuran) on corneal graft reaction.


Reconstruction of large defects of the upper eyelid.


Corneal transplantation in advanced Fuchs' dystrophy. The fate of homotransplanted human endothelial cells.


Water, sodium, and thiourea transcapillary diffusion in the dog heart.


Comparison of endogenous and exogenous gastrin in stimulation of acid and pepsin secretion.


Effects of carotid occlusion on dog forelimb vascular volume.


Fluorescent antibody technique as a diagnostic test for canine distemper infection: detection of viral antigen in epithelial tissues of experimentally infected dogs.


Isolation and identification of Clostridium hemolyticum in cattle in Florida.


Study of sheeppox virus synthesis by fluorescent antibody technique.


Current concepts of peritonitis.

Current concepts of peritonitis.


Repair of direct inguinal hernia without tension.


Management of the infected arterial prosthesis in the lower extremity.


Duplication of the stomach. Case report and review of the literature.


The serum lipid picture. A review.

The serum lipid picture. A review.


A comparison of the effects of chlorphentermine, diethylpropion and phenmetrazine on critical flicker frequency.


The time course of action of single doses of diazepam, chlorpromazine and some barbiturates as measured by auditory flutter fusion and visual flicker fusion thresholds in man.


The problems of LSD-25 and emotional disorder.


Rapid identification of tick-borne encephalitis virus by the fluorescent antibody technique. An immunofluorescence technique in tissue cultures and in mice, developed to provide a rapid means of identification of group B arboviruses, has been used to identify the tick-borne encephalitis virus. Identification in mouse-brain tissue was not possible when mice with vague clinical symptoms were used. Identification in chick-embryo-cell cultures was less time-consuming and laborious than identification in mouse brain, but more care was required, since only a small percentage of cells showed fluorescence. Identification can be accomplished in a few hours if mice in agony or cell cultures three to five days after inoculation are used.


Medicare and Medi-Cal.

Medicare and Medi-Cal.


Relative sensitivity and specificity of soluble antigens (metabolic and somatic) and whole cercariae in fluorescent antibody tests for schistosomiasis in humans and rabbits.


Effect of bacterial endotoxin on the course of Plasmodium berghei infection.


Early stress experiences mirrored in 'world' play test at five years.


Meditations on genesis.

Meditations on genesis.


In memoriam: James A. Johnson, Jr.--1917-1966.


Accidental changes in a donor kidney following kidney transplantation in a human presumably induced by cyclophosphamide (endoxan).


Group dynamics in the rehabilitation of hemiplegic patients.


Medicare. How to prove you're you.

Medicare. How to prove you're you.


Medicare nursing costs in relation to analysis of American Hospital Association Nursing Activity Project.


Payment of doctors' bills by medicare carriers.


Relative size of same and opposite sex drawings on the DAP as an index of dominance-submissiveness.


Edward Smith (?1818-1874), physiologist, human ecologist, reformer.


Flagellar motion and fine structure of the flagellar apparatus in Chlamydomonas. The biflagellate alga Chlamydomonas reinhardi was studied with the light and electron microscopes to determine the behavior of flagella in the living cell and the structure of the basal apparatus of the flagella. During normal forward swimming the flagella beat synchronously in the same plane, as in the human swimmer's breast stroke. The form of beat is like that of cilia. Occasionally cells swim backward with the flagella undulating and trailing the cell. Thus the same flagellar apparatus produces two types of motion. The central pair of fibers of both flagella appear to lie in the same plane, which coincides with the plane of beat. The two basal bodies lie in a V configuration and are joined at the top by a striated fiber and at the bottom by two smaller fibers. From the area between the basal bodies four bands of microtubules, each containing four tubules, radiate in an X-shaped pattern, diverge, and pass under the cell membrane. Details of the complex arrangement of tubules near the basal bodies are described. It seems probable that the connecting fibers and the microtubules play structural roles and thereby maintain the alignment of the flagellar apparatus. The relation of striated fibers and microtubules to cilia and flagella is reviewed, particularly in phytoflagellates and protozoa. Structures observed in the transitional region between the basal body and flagellar shaft are described and their occurrence is reviewed. Details of structure of the flagellar shaft and flagellar tip are described, and the latter is reviewed in detail.


Factors in the development of genetics in the United States: some suggestions.


In memoriam, Bruno Kisch (1890-1966).

In memoriam, Bruno Kisch (1890-1966).


Kopster: an etching by Cornelius Dusart (1660-1704). New Haven, Yale Medical Library, Clements C. Fry Collection.


Sir Philip Manson-Bahr.

Sir Philip Manson-Bahr.


The frustration of state medicine 1880-1899.


Sir William Osler and French medicine.

Sir William Osler and French medicine.


Edith Pechey-Phipson, M.D.: untold story.


The history of associationism and British medical psychology.


The reflex hammer. In memoriam Robert Wartenberg (1887-1956).


The occurrence of Bamble Disease (epidemic pleurodynia) in Norway.


A gynaecologist looks at the Tudors.

A gynaecologist looks at the Tudors.


The dissolution and the revolution in London hospital facilities.


Proper names--Zurich plethora.

Proper names--Zurich plethora.


The term 'causalgia'.

The term 'causalgia'.


Origins of legal medicine. Roman law: lex duodecim tabularum.


Fever, hemolytic anemia, and uremia.

Fever, hemolytic anemia, and uremia.


Qualitative analysis of dental prosthetic materials.


Joseph Henry and the National Academy of Sciences.


The loss of phenotypic suppression in streptomycin-resistant mutants.


Mechanism of hydrolysis of O-nitrophenyl-beta-galactoside in Staphylococcus aureus and its significance for theories of sugar transport.


The enzymatic repair of DNA. I. Formation of circular lambda-DNA.


National Academy of Sciences--July 1, 1967.


Mourner among the children. The psychological crisis of Emily Dickinson. I.


Psychotherapy of phobias.

Psychotherapy of phobias.


Data parallels across behavioral systems.


Transfer of puromycin-containing polypeptides through the plasma membrane of cartilage cells synthesizing collagen.


Treatment of perforating wounds of the colon and rectum: a reevaluation.


The acute treatment of heat stroke.

The acute treatment of heat stroke.


Prolapse of iris after keratoplasty.

Prolapse of iris after keratoplasty.


The detection of Vibrio fetus venerialis in the bull.


Henry Bearden Mulholland, M.D.

Henry Bearden Mulholland, M.D.


John Clark LeGrande.

John Clark LeGrande.


The in vivo effects of deglycerolized agglomerated erythrocytes transfused in multiple units to stable anemic patients.


Antibiotics literature index--a select bibliography.


Bacteriologic methods in the diagnosis of acute bacterial meningitis.


Studies on heat resistance with reference to coryneform bacteria: an improved technique using a multiple holder.


Review article: the course of microbial infection of the hen's egg.


An account of the University of Kansas School of Medicine.


Acute ketotic-type diabetic syndrome in sand rats (Psammomys obesus) with special reference to the pancreas.


Effect of CPIB ester on plasma free fatty acid levels in man.


Pollution of underground water from pea silage.


Study of a timed-release preparation of pentaerythritol tetranitrate.


Electron microscope studies of the Langerhans Islets in the toad pancreas.


Brian Lindsay Campbell.

Brian Lindsay Campbell.


Anthony Foster Crick. An appreciation.

Anthony Foster Crick. An appreciation.


Enuresis--a psychosomatic entity?

Enuresis--a psychosomatic entity?


Food habits in Western Tropical Africa.

Food habits in Western Tropical Africa.


Escherichia coli diarrhoea in children.

Escherichia coli diarrhoea in children.


Induced abortion in Japan--review of literature.


The effect of a new potent antifibrinolytic agent, tranexamic acid.


Distribution and biological effects of substance P.


Therapeutic test of diazepam (valium) in cerebral palsy.


Beta-glucuronidase activity and its variation with pH in human atherosclerotic arteries.


Oral and parenteral neomycin as a treatment for scours and salmonellosis in calves.


William H. Sanders, M. D. early leader in medical education and public health work in Alabama.


Speech pathology and audiology under Medicare.


Organophosphates of urine, including adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate.


The molecular mechanism of the enzymic reaction in RNA synthesis.


DNA turnover in a strain of Escherichia coli treated with mitomycin C.


The fate of heterologous DNA microinjected into eggs of amphibians during their development. II. Investigations by centrifugal chromatography on DEAE-cellulose paper pulp, ultracentrifugation in CsCl gradient and DNA-DNA hybridization in agar gel.


Concerning the dynamics of chromosome replication and degradation in a bacterial population exposed to X-rays.


Hydroxyurethane: dichotomy of action in bacterial and animal cells.


Resistance to actinomycin D of Escherichia coli after frozen storage.


Gastric secretory response of the unrestrained cat following electrical stimulation of the cingulate, thalamus, and mesencephalon.


Extraordinary recombinational events in Escherichia coli. Their independence of the rec+ function.


Thirty years of headache research in the laboratory of the late Dr. Harold G. Wolff.


An account of the University of Kansas School of Medicine.


N3-(2-aminoethyl)-5,5-diphenylhydantoin and derivatives.


I. The university in perspective: science, society, and service. 3. The university and the medical school. A study of their historical relationships.


Paralytic dislocation of the hip secondary to meningomyelocele.


Progress and stagnation in psychiatry during the past fifty years.


Head injuries "then and now" or diagnosis and treatment of head injuries 1939 versus 1965.


Some therapeutic disasters and their repercussions.


Marcello Malpighi and the dawn of neurohistology.


Dermatoglyphic analysis as a diagnostic tool.


The sesquicentennial of the university of Michigan's role in health.


Cerebral developmental anomalies and disturbances of language.


Cl-581: a new non-barbiturate short-acting anesthetic for surgery in burns.


Review of headache. II.

Review of headache. II.


New York, cradle of cryosurgery.

New York, cradle of cryosurgery.


Health officers of Cincinnati, Ohio and the problems of their day: 1900 to 1960. VII.


A method for orbital lining after exenteration.


Regeneration of deep defect in autogenous osteocartilaginous graft.


A study of parenzyme and varidase on the postoperative rhinoplasties of two sets of identical twins.


Regional and local societies of plastic and reconstructive surgery.


New opportunities for improving health care.


Present knowledge of protein nutrition. I.


The radiation sensitivity of Escherichia coli B: a hypothesis relating filament formation and prophage induction.


Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli.


Ribosomal proteins of Escherichia coli. I. Demonstration of different primary structures.


Isolation of a protein coded for by the permease gene of the Lac operon of Escherichia coli.


Studies in the psychological effects of a new drug (diethylpropion). Time curves for five subjective variables.


The dysacromelias.

The dysacromelias.


End results in the treatment of scoliosis. A survey of 57 cases.


Thresholds for the perception of angular acceleration in man.


Roentgenology of ventriculo-atrial shunts for the treatment of hydrocephalus.


Evaluation of complication rates of meglumine diatrizoate and meglumine iothalamate in cerebral angiography.


Gilbert W. Heublein, M.D. 1908-1967.

Gilbert W. Heublein, M.D. 1908-1967.


Comparative investigations on different methods for the determination of the sensitivity of bacteria to antibiotics.


Bibliographical note. G. H. Mead.

Bibliographical note. G. H. Mead.


Trinity Medical School.

Trinity Medical School.


Preparation and composition of the protoplast membrane of Candida utilis.


Measurement of aortic failure by the dyes method.


Abnormal phosphorus metabolism in a potassium transport mutant of Escherichia coli.


A critical study of the literature concerning rigidity.


The sclerocystic ovary syndrome.

The sclerocystic ovary syndrome.


Morphological changes in radioprotected, lethally irradiated, and bone-marrow treated animals.


An observation on the yellow fever epidemic, Memphis and Shelby County Tennessee in 1878.


Reading disability: a neurological deficit?


The effects of plasma and erythrocyte factors on the erythrocyte sedimentation rate.


Experimental and clinical comparative study of iron carbohydrate complex with ferrous gluconate.


Laboratory studies on meningitis in North Kerala.


Proflavine binding to transfer ribonucleic acid, synthetic ribonucleic acids, and deoxyribonucleic acid.


Studies on the interaction  between regulatory enzymes and effectors. I. Effect of adenosine 5'-monophosphate analogues on threonine deaminase.


The 5'-nucleotidase of Escherichia coli. I. Purification and properties.


The 5'-nucleotidase of Escherichia coli. II. Surface localization and purification of the Escherichia coli 5'-nucleotidase inhibitor.


An experimental multiple barbed suture for the long flexor tendons of the palm and fingers. Preliminary report.


The Z-plasty in hand surgery.

The Z-plasty in hand surgery.


In memoriam Philip Wiles, 1899-1967.

In memoriam Philip Wiles, 1899-1967.


In memoriam Hubert Chitty, 1882-1966.

In memoriam Hubert Chitty, 1882-1966.


Bibliography on Medical Education for 1966. An Index to the World Periodical Literature related to Education for Medicine.


Dichoptic interactions of lateral geniculate neurons of cats to contralateral and ipsilateral eye stimulation.


A multitrait multimethod measurement approach to the traits (or states) of anxiety, depression and hostility.


Studies of Rorschach content: a review of research literature. II. Non-traditional uses of content indicators.


A comparison of drawings and sentence completion responses of congenital heart children with normal children.


Mitral replacement. Review of six years' experience.


Myocardial revascularization by internal mammary artery implant procedures. Clinical experience.


New form and ID card help clinic speed Medicare patient processing.


Medicare boosts bed usage by elderly.

Medicare boosts bed usage by elderly.


Mutation of Salmonella typhimurium by nitrosoguanidine.


Mutagenesis by acridine orange and proflavine in Escherichia coli strain S.


Activating the inactive nurse: a historical review.


Attainment of the maternal role. 2. Models and referrants.


Some evolutionary concepts of human reproduction.


Correlation of pregnancy wastage and hypoplasia of placental syncytium. Study by phase-contrast microscopy.


Contractility of the nonpregnant human uterus.


Medicare and the pharmacist.

Medicare and the pharmacist.


Methysergide for migraine.

Methysergide for migraine.


General practitioner clinical trials. Two new psychotropic drugs.


The James Mackenzie lecture. Learning and teaching by family doctors.


Infectious diseases. Annual review of significant publications.


An historical analysis of the Freudian conception of the superego.


From natural science to social science.

From natural science to social science.


Contributions to the history of psychology. IV. Joseph Buchanan (1785-1829) and the "law of exercise" (1812).


Contributions to the history of psychology. 3. G. W. Leibniz (1646-1716) on the association of ideas and learning.


On the futility of aggregating individual learning curves.


A pictorial technique for obtaining social desirability ratings from young children.


The human body and bacteria. 8. Evaluation of clinical procedures with special attention to the matter of "controls".


Samuel Clifton Baldwin: pioneer orthopedist.


Highlights of early surgery in Utah.

Highlights of early surgery in Utah.


Scientific biography: work will contain articles on 5000 scientists.


Protein components in the 40s ribonucleoprotein particles in Escherichia coli. The 40S ribonucleoprotein particle in Escherichia coli cells, accumulated in the presence of a low concentration of chloramphenicol, lacks at least four ribosomal structural protein components which are present in the mature 50S ribosomal subunit. The 40S ribonucleoprotein prepared by exposing the 50S ribosomal subunit to a concentrated lithium chloride solution may also be deficient in the same protein components.


Otolithic membranes of the saccule and utricle in man. The otolithic membranes of the human saccule and utricle can be prepared as whole mounts or surface specimens for microscopic examination. They are not simple, homogeneous, gelatinous structures as heretofore described. Instead, each shows a definite and characteristic fibrillar design, which appears to be correlated with the known cytoarchitectural pattern of the underlying neuroepithelium.


The impact of recent social legislation on the health professions.


Stimulatory and depressant effects of nitrogen mustard on protein synthesis in a cell-free system.


Events and the man (John Alexander).

Events and the man (John Alexander).


A paraffin technique for processing eyes.


Harris Stanley De Silva.

Harris Stanley De Silva.


American society of medical technologists. 1966-67 directory of officers and committee chairmen.


Faculty focus: on Cameron Haight, M. D.

Faculty focus: on Cameron Haight, M. D.


Electronic processing of laboratory data: analysis of bacteriology findings.


Antibiotics literature index--a select bibliography.


Non-specific inhibition of virus hemagglutination: a review.


Leucorrhoea due to Trichomonas vaginalis--clinical trial with hamycin.


Adolf Meyer's two and a half years at Kankakee. May 1, 1893-November 1, 1895.


Consanguinity--a review.

Consanguinity--a review.


Sanitary reform in New York City: Stephen Smith and the passage of the Metropolitan Health Bill.


The "Sabio" and "Sylvester" families of anatomical fugitive sheets: note on a pair of sheets in the National Library of Medicine.


Corticosteroids in dermatology.

Corticosteroids in dermatology.


E. coli antibiotic resistance transfer.

E. coli antibiotic resistance transfer.


A new histological technique.

A new histological technique.


Tribute to Harry Loren Arnold, Jr., on the 25th anniversary of the H.M.J.--1941-1966.


Progress in dermatology.

Progress in dermatology.


Results of medicare surveys of Iowa hospitals.


The thymus.

The thymus.


The effect of thiethylperazine on nausea, vomiting and vertigo.


Medical schooling in South Carolina. IX. Prosperity (1824-1861), disaster (1861-1865), survival (1865-1913).


Animal reservoirs of hydatid disease (Echinococcus granulosus) in Lebanon and Syria with a review of the world literature on E. granulosus infections in foxes.


The evolution of the child welfare services in England and Wales.


A review of eighty-nine renal transplantations at the Cleveland Clinic.


The problem of donor eyes. A review.

The problem of donor eyes. A review.


Social Security health insurance benefits for the aged. Title 18.


An evaluation of some models of laterality. Effects in dichotic listening.


State mourns passing of Dr. W. M. Whitehead.


Of the times and the tides. Epilogue.

Of the times and the tides. Epilogue.


New members and associates OF THE American Psychological Association.


Infiltration and thrombosis in atherogenesis. A study using immunofluorescent techniques.


The reliability and validity of the Goodenough-Harris drawing test.


Developmental changes in children's drawings.


Tinea nigra.

Tinea nigra.


Intelligence assessment: a theoretical and experimental approach.


Histochemical changes in the tissues of different types of leprous lesions.


Freedom--the wave of the future.

Freedom--the wave of the future.


Management of deafness in otitis media with effusion.


Further evidence that UGA does not code for tryptophan.


Spontaneous revertants of amber mutants.


Tissue preparation for electron microscopy.


Catalysis of peptide bond formation by 50 S ribosomal subunits from Escherichia coli.


Isolation of selected segments from the genome of Hfr Escherichia coli.


Role of DNA in RNA synthesis. XI. Selective transcription of gamma DNA segments in vitro by RNA polymerase of Escherichia coli.


Relative transcription activity of different segments of the genome throughout the cell division cycle of Escherichia coli. The mapping of ribosomal and transfer RNA and the determination of the direction of replication.


Distribution of the DNA and the DNA-histone antigens in the nuclei of free-living and parasitic Sarcomastigophora.


The time of DNA synthesis during the interdivision growth cycle of Tetrahymena pyriformis fed on living bacteria.


New York's first medical school; King's College (Columbia), 1767-1775.


John Jones (1729-1791) physician to Washington and Franklin.


A study of thioridazine and its side-chain derivative, mesoridazine, in chronic male hospitalized psychiatric patients.


Tranquilizers in the management of alcoholics: a review of the literature to 1964. I.


Lack of addiction from high doses of tybamate.


Pressure relief in plate prosthesis.

Pressure relief in plate prosthesis.


Symptom expression as a form of primitive decentering.


Word-frequency effect and response bias.


Motivational and emotional controls of cognition.


Stimulus generalization and the matching principle.


Parallel functions of serial learning and tachistoscopic pattern perception.


Linear theory of performance.

Linear theory of performance.


Pavlovian conditioning and its proper control procedures.


Diagnostic problems in obliterative arterial disease elucidated by measurment of peripheral blood flow.


Antibody to intrinsic factor and parietal cells in gastric diseases.


Antibody-producing cells in division.

Antibody-producing cells in division.


Autonomic basis for the rise in brain temperature during paradoxical sleep. The rise in brain temperature in the rabbit during paradoxical sleep originates in a temperature rise of the cerebral arterial blood. Heat loss from the ear is a major factor in the regulation of arterial blood temperature in the rabbit, and the primary thermal event in paradoxical sleep is a vasoconstriction of the skin of the ear which results in a rise in arterial blood and brain temperatures. These thermal correlates of paradoxical sleep are not present in a cold environment when the ear skin is already maximally vasoconstricted. The persistence of peripheral vasoconstriction during paradoxical sleep in a hot environment suggests a disturbance in autonomic thermoregulatory control.


New historical information on the Cleveland operations.


Heterotopic autotransplantation of the canine PANCREAS.


W. Somerset Maugham (1874-1965): a medical truant.


Reconstruction of efferent pathways to the urinary bladder in a paraplegic child.


Dr. George Glentworth (1735-1792): "a physician eminent and useful".


The balloon catheter in vascular surgery.


The Albert Einstein Medical Center of Philadelphia: first 100 years.


The early Ovariotomists--pioneers in abdominal surgery.


"On guard at the gateway".

"On guard at the gateway".


Integrated effect of psychotropic drugs on the balance of cholino-, adreno-, and serotoninergic processes in the brain as a basis of their gross behavioral and therapeutic actions.


Morton David Bogdonoff, MD. Chief editor Archives of Internal Medicine.


"Immunologic" oncogenesis.

"Immunologic" oncogenesis.


Mexican phantastica--a study of the early ethnobotanical sources on hallucinogenic drugs.


Maternal-fetal thyroid relationships in health and in disease.


A means of speaking for patients with cuffed tracheostomy tubes.


Reticulum cell sarcoma of the breast.

Reticulum cell sarcoma of the breast.


The use of Hexanicotol (inositol niacinate) in peripheral vascular disease.


Crabtree effect in some bacterial cultures.


Characteristics of mutations appearing spontaneously in extracellular particles of bacteriophage T4.


Present status of the serum complement system.


Mapping of integration and excision crossovers in superinfection double lysogens for phage lambda in Escherichia coli.


Rizal, as a contemporary of Freud.

Rizal, as a contemporary of Freud.


The L-rhamnose genetic system in Escherichia coli K-12.


Radioimmunoassays. I. General principles and methods.


AMA sticks to its reservations about Medicare at clinical meeting.


Aerospace technology and its application to parenteral operations. II.


SSA's machinery for processing Medicare claims.


An interview with Robert M. Ball.

An interview with Robert M. Ball.


Reticuloendothelial neoplasms involving the spinal canal of cats.


The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. VI. Enzymatic transfer of galactose, glucose, N-acetylglucosamine, and colitose into the polymer.


The mechanism of action of cobamide coenzyme in the ribonucleotide reductase reaction.


The intracellular concentration of bound and unbound magnesium ions in Escherichia coli.


Adsorption of free fatty acids on cells of certain microorganisms.


Methods for isolation and enumeration of lipolytic organisms.


The structure of the cochlea in Chiroptera. 3. Microchiroptera: Phyllostomatoidea.


Neonatal varicella. Report of a case in a five-day-old infant and review of the literature.


Topical antiperspirants.

Topical antiperspirants.


Endotoxin shock: alterations in cardiac output and regional blood flow, with modifications resulting from whole blood transfusion with and without ganglionic blockade.


Comparative vascular responses to endotoxin, tourniquet removal and hemorrhage.


Efficacy of buffered saline as the sole replacement fluid following acute measured hemorrhage in man.


The role of residential care--past, present and future.


Living with emphysema.

Living with emphysema.


Dental care programs: prospects and perspectives.


Common antigenicity of avian reoviruses.


Detection of Vibrio fetus from bulls by means of fluorescent antibody techniques.


Amyloidosis.

Amyloidosis.


Epochs in obstetrics.

Epochs in obstetrics.


Specific foods and flatulence.

Specific foods and flatulence.


Variability in basal metabolic rate (BMR).


Immunity of mature arterial plaque to hypercholesteremia.


Adrenalectomy and the digestion and absorption of fat.


The effect of nutrition on body composition.


Nutrition and learning behavior.

Nutrition and learning behavior.


The effect of ethanol ingestion on liver dehydrogenases in various vitamin deficiencies.


Iron-55 levels in fish and in fish-eating populations.


Acetate metabolism in ruminant tissues.

Acetate metabolism in ruminant tissues.


Nutritional value of safflower meal.

Nutritional value of safflower meal.


Body conformation, coronary heart disease, and longevity.


Pyridoxine deficiency and acute porphyria.


Dietary fat and neoplasms in man.

Dietary fat and neoplasms in man.


The surgical approach to hypercholesteremia: ileal bypass.


Abraham Portaleone. Italian physician, erudite scholar and author, 1542-1612.


Etrafon: a three year study.

Etrafon: a three year study.


Routine rectal swab culture. An epidemiological survey in the elderly.


A clinical trial of troxerutin in venous insufficiency of the lower limb.


Troxerutin in the treatment of haemorrhoids.


A record in royal attendance. William Heberden, M.D. (1710-1801) and William Heberden, M.D. (1767-1845).


Differential sensitivity of two palmar sweat measures.


Orientation of nonsense codons on the genetic map of the lac operon. Intracodon recombination is used to orient the nonsense codons UGA, UAG, and UAA on the genetic map of the (lactose) lac operon of Escherichia coli. The 5'-end of these triplets is toward the operator end of the operon. A hypothesis is presented to explain the fact that the frequency of recombination between adjacent nucleotides is many times lower than expected.


Glyceraldehyde-3-phosphate dehydrogenase variants in phyletically diverse organisms. Electrophoretically distinct forms of glyceraldehyde-3-phosphate dehydrogenase (TDH) have been detected in turtle, perch, trout, spinach, and yeast. Multiple forms were not detected in rat, rabbit, chicken, frog, honey bee, Euglena, or Escherichia coli. The combination of two different subunits into tetramers is a probable explanation for the five-membered sets usually detected in extracts exhibiting TDH multiplicity.


Heterophile reactive antigen in infectious mononucleosis. Specific heterophile reactive antigen has been localized by means of indirect immunofluorescence in 12 of 13 kidney biopsy specimens obtained during the acute phase of infectious mononucleosis. I feel that this may represent the identification of infectious agent antigen. Evidence is also presented for the possible existence of two different strains of the agent of infectious mononucleosis.


Cell synchrony.

Cell synchrony.


Studies on the hydroxylation and metabolism of delta 4-androstene-3, 17-dione-7H3 in the human corpus luteum tissue.


The incidence of infective drug resistance in strains of Escherichia coli isolated from diseased human beings and domestic animals.


Rolf Sievert in memoriam.

Rolf Sievert in memoriam.


The enigma of Michelangelo's Pietà Rondanini. A study of mother-loss in childhood.


The metaphor of the journey in "The Interpretation of Dreams".


Use of externally recorded radioisotope-dilution curves for quantitation of left to right shunts.


The control of sodium excretion with normal and reduced nephron populations. The pre-eminence of third factor.


Use of skin grafts in the mouth in the management of oral cancer.


Immediate reconstruction of the resected mandibular arch.


The history of cardiac glycosides.

The history of cardiac glycosides.


The diagnostic value of an antinuclear antibody test in clinical dermatology.


Differentiation of cutaneous anaerobic bacteria. The use of the replica plating technique.


Serodiagnosis of syphilis.

Serodiagnosis of syphilis.


The evolution of concepts of melanin biology.


Dermatology at Blockley--100 years ago.

Dermatology at Blockley--100 years ago.


The Chediak-Higashi syndrome and Aleutian mink.


Prof. Edward Zebrowski; scientist, researcher, teacher.


Obstruction of superior vena cava and pulmonary artery by malignant thymoma. Hemodynamic and angiographic observations of a case.


Extended care benefits under Medicare: implications for hospitals and nursing homes.


Osteopathic hospitals.

Osteopathic hospitals.


A sixteenth century midwife's license.

A sixteenth century midwife's license.


The Begetting of Fools: an annotated translation of Paracelsus' De Generatione Stultorum.


A critical evaluation of processed calf bone.


William Harvey's methodology.

William Harvey's methodology.


Full-thickness sole-skin grafts for resurfacing the hand.


Synovectomy of the distal two joints of the thumb and fingers in rheumatoid arthritis.


The American Orthopaedic Association: the past, the present, the future.


A universal system for identifying permanent and primary teeth.


Reactions to implants of conventional and new dental restorative materials.


A recent analysis of traumatic injuries to children's teeth.


Report of the increase in bicanine diameter in 2 to 4-year-old children.


The prevalence of supernumerary teeth in primary and mixed dentitions.


Effect of premature loss of primary molars on the anteroposterior position of maxillary first permanent molars and other maxillary teeth.


Restorative dentistry under general anesthesia for the exceptional child--as an office procedure.


An evaluation of audio-analgesia effects.


Comprehensive restorative procedures for primary anteriors.


Enumeration of cellulolytic cocci in sheep rumen by using a fluorescent antibody technique.


Analyses of lipopolysaccharides extracted from penicillin-resistant, serum-sensitive salmonella mutants.


The role of the home health agency in health care for our citizens.


Crawford Williamson Long--discoverer of surgical anesthesia.


Tension pneumothorax in the newborn.

Tension pneumothorax in the newborn.


Pneumoconio-tuberculosis in soft coal miners: comparison of course, prognosis and physiologic impairment in non-miners with tuberculosis.


A perfusion chamber for continuous microscopical observations of living cells in culture.


Epidemiology of chronic bronchitis.

Epidemiology of chronic bronchitis.


The present status of mammography.

The present status of mammography.


Transplantation of the kidney.

Transplantation of the kidney.


Acute diarrheal disease.

Acute diarrheal disease.


A double-blind study of d-isoephedrine combined with chlorpheniramine in symptomatic relief of hay fever.


Inguinal hernia in the elderly.

Inguinal hernia in the elderly.


The investigation of pancreatic function in pancreatitis.


Thoracic aneurysms.

Thoracic aneurysms.


Theophylline-niacinamide in the relief of bronchospasm.


Transpiration and energy exchange.

Transpiration and energy exchange.


The pancreas and diabetes mellitus.

The pancreas and diabetes mellitus.


Seafarers' scourge.

Seafarers' scourge.


Mechanisms of guard cell action.

Mechanisms of guard cell action.


Phosphorus in sewage, polluted waters, sludges, and effluents.


Within the purview of the AMA.

Within the purview of the AMA.


The ginkgo, the most ancient living tree. The resistance of Ginkgo biloba L. to pests accounts in part for the longevity of this species. Fossil records clearly demonstrate that the group of trees known as Ginkgoales, of which today Ginkgo biloba is the sole living member, date back over 200 million years. Ginkgo bilboa itself is one of the oldest of living plants (4). It appears that the longevity of this tree and its long reproductive period are at least partially responsible for the persistence of the species. The resistance of these trees to pests such as insects, bacteria, viruses, and fungi has been studied. It is believed that their unusual resistance to pests accounts in part for the longevity of the trees and also, in turn, for the longevity of the species.


Woods Hole: summer mecca for marine biology.


Abscess formation complicating myocardial infarction.


Phenotype masking and streptomycin dependence. In attempting to define the role of ribosomes in the mechanism of streptomycin dependence, a new phenomenon has been discovered. Analysis of this phenomenon-called phenotypic masking-leads to the conclusion that "streptomycin dependent" mutants are actually "drug dependent" because their dependence is equally satisfied by several drugs. These drugs, some of which are totally unrelated chemically, act on the ribosome and induce misreading in vitro and suppression in vivo.


Dimethyl sulfoxide in dermatology.

Dimethyl sulfoxide in dermatology.


Comparative therapy of tropical ulcer.

Comparative therapy of tropical ulcer.


A review of helminthiasis in the western region of Nigeria with special reference to the Ibadan area. II.


Enteropathogenic Escherichia coli diarrhea in western Alaska.


[75th anniversary of Col. MC Ret. Julius Caesar, MD].


In vitro cultivation of rabbit ova following in vitro fertilization in tubal fluid.


Aseptic meningitis in siblings with infectious mononucleosis.


Introduction of the auscultatory method of measuring blood pressure--including a translation of Korotkoff's original paper.


A new look at some old questions in clinical electrocardiography.


An account of the University of Kansas School of Medicine.


The successful 48 hour storage of the canine kidney by hypothermia alone.


Neurological aspect of systemic lupus erythematosus.


Board of Medical Examiners of Maryland addenda to Directory of Registered Physicians, physicians registered May 1, 1966 to July 30, 1966.


The Baltimore City Hospitals under the Department of Public Welfare: social change (1935-1955).


History and objectives of the AAGP.

History and objectives of the AAGP.


Prostatic corpora amylacea.

Prostatic corpora amylacea.


Attachment behavior of mammals.

Attachment behavior of mammals.


Partial reinforcement: a hypothesis of sequential effects.


Oxyphenbutazone (tandearil) in rhinoplasty. A clinical evaluation of effectiveness. To evaluate the effectiveness of Oxyphenbutazone as an anti-inflammatory agent, a double-blind study of Oxyphenbutazone and a placebo in a group of 42 patients who had nasal cosmetic operations involving osteotomy was carried out. The observations included direct objective measurement of the width of the palpebral fissure after operation, grading of the severity of postoperative edema and ecchymosis from photographs, and observations by the patients regarding the clearing of the postoperative discoloration. It appeared from the results of these observations that Oxyphenbutazone is not effective in preventing postoperative edema in such operations or in promoting more rapid resolution of postoperative edema. It did appear to enhance the clearing of postoperative periorbital ecchymosis.


Canadian Society of Laboratory Technologists.


Medicare and medi-cal to date.

Medicare and medi-cal to date.


Drug resistance of malaria parasites in Tanzania.


James Gates Percival (M.D. Yale 1820), Once our nation's most promising poet.


Hypnopedia in the Soviet Union: a critical review of recent major experiments.


Depression in childhood. A survey of some pertinent contributions.


Simultaneous hard and soft tissue sectioning using polyester resin as an embedding medium.


A clinical trial of sulforthomidine ('Fanasil' Roche) in lepromatous leprosy.


Demodicidiasis and leprosy.

Demodicidiasis and leprosy.


A method of medial tarsorraphy for correction of lagophthalmos and ectropion.


Cancer chemotherapy. II.

Cancer chemotherapy. II.


Antonio Cocchi's sojourn in England.

Antonio Cocchi's sojourn in England.


A decade of research on the education of the mentally retarded. A selected review.


Mental retardation and religion. (An annotated bibliography).


Mechanism of action of aldosterone.

Mechanism of action of aldosterone.


Motor functions of the ruminant forestomach.


Quinones in energy-coupling systems.

Quinones in energy-coupling systems.


Iron metabolism and kinetics.

Iron metabolism and kinetics.


Mucosal block. An evaluation of concepts relating to control of iron absorption.


Clinical aspects of iron metabolism.

Clinical aspects of iron metabolism.


The anemia of chronic disorders.

The anemia of chronic disorders.


Pennsylvania Academy of Ophthalmology and Otolaryngology.


Comparative assay of endotoxins by oral and parenteral administration.


Review article: neurological complications occurring in hospitalized patients.


Public health in the contexts of its social, biological, and medical origins.


Persistent preoperative conjunctival contamination by Escherichia coli: a case report.


Current problems in pediatric nutrition.


Openness of perception as a condition for creativity.


Topical treatment of chronic discoid lupus erythematosus with betamethason-17-valerate and fluocinolone acetonie-a double blind study.


Histochemical changes in the tissues of different types of leprous lesions.


New fellows, associates and junior members. International college of surgeons.


Preliminary clinical evaluation of a new appetite suppressant. A double-blind study.


Value of a diuretic in suppressing breast engorgement.


Sir James Young Simpson--"the splendid ultimate triumph".


Sir James Young Simpson: victo dolore.

Sir James Young Simpson: victo dolore.


Stereotactic thalamotomy in pain relief.


Identification of some common gram-negative bacteria.


The storage of washed suspensions of Staphylococcus aureus.


The coming of modern medicine to Haywood County.


Present knowledge of folacin.

Present knowledge of folacin.


"Loss-of-control" drinking in the abstinent alcoholic.


Weight loss and serum lipids.

Weight loss and serum lipids.


Early feeding of the premature infant.

Early feeding of the premature infant.


Rampant caries in the pre-school child.

Rampant caries in the pre-school child.


Weight regulation.

Weight regulation.


Weight gain during drug treatment for reduction of serum cholesterol.


Copper toxicity.

Copper toxicity.


Nutritional state and hormonal regulation of liver enzymes.


Congenital supravalvular aortic stenosis, idiopathic hypercalcemia, and vitamin D.


Multiple factors altering radiation sensitivity.


Fasting metabolic rate of cattle.

Fasting metabolic rate of cattle.


Fantasy need achievement as a motivational construct.


Differentiation of capsules and hyphae in clubs of bovine sulphur granules.


50th anniversary of the Illinois Society.


Value of the cytologic examination for the early detection and treatment of cancer of the colon.


A rapid method of reparaffinizing tissue.


Resistance of the Klebsiella-Aerobacter-Serratia division to cephalothin and ampicillin. Importance of identification and nomenclature.


Ophthalmology at the University of Pennsylvania: a chronology.


A silver pitcher for Dr. Nathaniel Chapman.


Memoir of Stoughton Ralph Vogel (1907-1966).


Helminthiasis.

Helminthiasis.


Aflatoxin (a review article).

Aflatoxin (a review article).


A rationale basis for the use of antibiotics and chemotherapeutic agents in gastrointestinal surgery.


Long-term heparin treatment in ischaemic heart disease. Effects on clinical condition and plasma lipids.


The immunologic problem of pregnancy. 3. Effect of pregnancy on survival of adult and neonatal skin grafts.


The immunologic problem of pregnancy. IV. Histocompatibility antigens of aging mouse trophoblast.


Effects of a hyperbaric environment on gas exchange and ventilation in patients with chronic bronchitis and emphysema.


Studies of a new humidifying device as a potential source of bacterial aerosols.


Neurologic allergy: the problem of classification.


Mineral oil as a human carcinogen, fact and fiction.


Cytologic diagnosis from tumor tissue using the "quick method" during operation.


In memoriam. Benjamin F. Glasser, M.D. 1899-1967.


A review of hearing damage risk criteria.


Oral contraceptives: the first decade.

Oral contraceptives: the first decade.


Triamcinolone acetonide in flexible collodion for dermatologic therapy.


Psychotomimetic indoles in the Convolvulaceae.


Frank Aubrey Weight.

Frank Aubrey Weight.


A heritage of freedom.

A heritage of freedom.