Current concepts. Napalm.

Current concepts. Napalm.


Carl Axel Gemzell.

Carl Axel Gemzell.


The use of colloidal carbon as a tracer for vascular injury. A review.


The etiology of pellagra and its significance for modern medicine.


The atypical lymphocyte.

The atypical lymphocyte.


Malignancy in adult coeliac disease and idiopathic steatorrhoea.


Proline metabolism in Escherichia coli. IV. Preparation of proline-2- and proline-5- 3H and location of 3H in proline.


Management of chloroquine-resistant falciparum malaria.


Chronic myelogenous leukemia. Possible association with reticulum cell sarcoma.


One stage urethroplasty. Report of two cases.


Supplemental sulfone (dapsone) therapy. Use in treatment of chloroquine-resistant falciparum malaria.


An operative technique for the treatment of pilonidal sinus.


A quantitative assay for DNA-DNA hybrids using membrane filters.


Ribosome production during recovery from puromycin treatment: influence of 5-fluorouracil.


Selectivity for thymine over 5-bromouracil by a thymine-requiring bacterium.


Synthesis of enzymes of the lactose operon during diauxic growth of Escherichia coli.


Protein synthesis in Bacillus stearothermophilus.


Evidence for the direct conversion of chloramphenicol particles into ribosomes in Escherichia coli.


Synthesis of ribonucleic acid and protein during inhibition of Escherichia coli by analogues of amino acids.


Stimulation of amino acid incorporation in vitro by DNA: different effects of aminoglycoside antibiotics in calf-thymus nuclear and bacterial ribosome systems.


Clinical trials of tolnaftate and variotin.


Angular cheilosis and dentures.

Angular cheilosis and dentures.


Gastric biopsy--a critical evaluation.

Gastric biopsy--a critical evaluation.


Studies in the U.S.S.R. on the distribution, circulation, and fate of carcinogenic hydrocarbons in the human environment and the role of their deposition in tissues in carcinogenesis: a review.


On the biosynthesis of hemoglobin.

On the biosynthesis of hemoglobin.


Incorporation of p-fluorophenylalanine into protein by a cell-free system.


Distribution of the activity of various hydrolases, transaminases, and glutamic dehydrogenase in the digestive tracts of fed and fasted rats.


Succinylation of pepsinogen.

Succinylation of pepsinogen.


Biosynthesis of phosphatidic acid, lysophosphatidic acid, diglyceride, and triglyceride by fatty acyltransferase pathways in Escherichia coli.


A kinetic study of the reaction mechanism of tryptophanase-catalyzed reactions.


The enzymology of virus-infected bacteria. X. A biochemical-genetic study of the deoxynucleotide kinase induced by wild type and amber mutants of phage T4.


The purification of aspartate transcarbamylase of Escherichia coli and separation of its protein subunits.


A review of detection methods for the early diagnosis of lung cancer.


The effect of zinc oxide and eugenol on microorganisms in the dental pulp.


The clinical comparison of a spherical amalgam alloy and a conventional amalgam alloy: a pilot study.


Report of a study demonstrating improved oral health through education.


Current concepts in periodontal disease.


A clinical and television densitometric evaluation of the indirect pulp capping technique.


A long and happy love affair between the man and medicine.


Dr. Milford O. Rouse new AMA president.

Dr. Milford O. Rouse new AMA president.


Bibliography on Medical Education. Citations obtained through the National Library of Medicine's MEDLARS Program.


18O labeling of deoxyribonucleic acid during synthesis and stability of the label during replication.


Inhibitory effeft of oxidized spermine on the multiplication of coliphage T5.


Fractionation of a suppressor sRNA.

Fractionation of a suppressor sRNA.


Sudden and unexpected non-traumatic deaths in adults: a review of epidemiological and clinical studies.


Determination of streptomycin sensitivity by a subunit of the 30S ribosome of Escherichia coli.


Streptomycin sensitivity and the structural components of the 30S ribosomes of Escherichia coli.


Studies of a phage-induced DNA methylase.


Protein synthesis in a relaxed-control mutant of Escherichia coli upon recovery from methionine starvation.


Properties of a mutant blocked in inducibility of messenger RNA for the galactose operon of Escherichia coli.


Two phenomena associated with skin grafting from tumor-bearing syngeneic donors.


Measurement and interpretation of intelligence (IQ).


Effects of growth hormone on the rate of disappearance of insulin from blood in depancreatized and Houssay dogs.


Differentiation of epidermis and epidermal derivatives.


The determination of molecular weights of biological macromolecules by ultracentrifuge methods.


The photochemical and macromolecular aspects of vision.


The structure and interactions of myosin.


The effects of radiations on DNA biosynthesis and related processes.


Ribonucleic acid and hormonal control of protein synthesis.


A review of the use of tannic acid in patients with ulcerative colitis.


Unusual symptomatic arch anomalies.

Unusual symptomatic arch anomalies.


Radioisotope techniques for instruction in the biological sciences. A list of annotated references. TID-21262 (Rev.).


Radioisotopes in the biological sciences. An annotated bibliography of selected literature. TID-3585.


Purification and properties of ribonucleic acid polymerase from Escherichia coli. LA-3638.


Incidence of Bordetella bronchiseptica in wildlife and man in iowa.


Association of Escherichia coli with diarrheal disease of the newborn pig.


Continuous recording of the growth of leptospira, staphylococcus, pasteurella, haemophilus, and erysipelothrix species.


Total body water and water turnover in sheep.


The isolation and characterization of Moraxella bovis.


The effect of aeration upon the growth of leptospira serotypes.


The ionic mechanisms of excitatory and inhibitory synaptic action.


A review of schizophrenia in childhood.

A review of schizophrenia in childhood.


Gilles De La Tourette's disease. The past and the present.


Diagnostic labels in the history of schizophrenia.


Criteria for identification of a central nervous system transmitter.


Recent studies of the properties of nudibranch nerve cells.


Transmission of hog cholera by pregnant sows.


The diagnosis of hog cholera by a fluorescent antibody test.


Some properties of DNA from phage-infected bacteria. Replicating T5 or lambda phage DNA has been labeled by adding tritiated thymidine for short periods to cultures of phage-infected Escherichia coli before isolation of intracellular DNA. Two procedures are described for separating T5 replicating DNA from DNA of intracellular phage particles. Both T5 and lambda replicating DNA had the same bouyant density in cesium chloride as DNA from phage particles but sedimented faster when centrifuged in sucrose density gradients. The fast sedimentation did not appear to be caused by DNA protein or DNA-RNA complexes or by aggregation of DNA, but is probably due to DNA molecules of unusual structure. Experiments involving hydrodynamic shear and sucrose density gradient centrifugation at alkaline pH have suggested that with lambda the replicating form of DNA is a linear molecule considerably longer than the DNA molecules of lambda-phage particles. The constituent polynucleotide chains of lambda but not T5 replicating DNA also appear to be longer than those of phage DNA.


Membrane structure and function.

Membrane structure and function. An understanding of the biochemical basis of membrane function is an important goal of present day biology. In this paper, a biochemical approach to the problem of the specific transport of sugars across the membrane of Escherichia coli is discussed. A new biochemical model for lactose transport system in this organism is presented, in which a specific membrane protein (M protein) plays the role of the sugar carrier. Experiments which have led to the discovery of such a protein, its specific labeling, and partial purification are briefly reviewed.


Enzymatic mechanisms of DNA replication. DNA polymerases purified from several sources are characterized by replication of the 3'-hydroxy-terminated strand of a helical template. Failure to achieve simultaneous replication of the 5'-strand leads to aberrations in the synthesized DNA, described as nondenaturability and branching. Aberrations in synthesized DNA were not observed when (a) the 5'-strand was destroyed by a specific nuclease during the course of replication or (b) a single-stranded (circular) phage (M13) DNA served as template. Replication of a single-stranded, circular DNA produced a helical product, but the nature of initiation of a new strand by the circular template remains to be explained. Hypothetical mechanisms for simultaneous replication of the 5'-strand are presented as is the possibility that the tertiary structure of the DNA, as for example, a circular form of the helix, is of prime importance in in vivo replication.


Imipramine (Tofranil vs. placebo in hospitalized psychotic depressives. (a comparison of patients' self-ratings, psychiatrists' ratings and psychological test scores).


Methylation of DNA.

Methylation of DNA. The methylated bases of DNA are formed by the transfer of the methyl group from S-adenosylmethionine to a polynucleotide acceptor. This transfer is catalyzed by highly specific enzymes which recognize a limited number of available sites in the DNA. The mechanism for the recognition is presently unknown. In some instances, there is evidence that other cellular components, such as lipopolysaccharides, can influence the methylation reaction. Certain bacteriophages induce new methylases upon infection of their hosts. Phage T3 is unique in establishing an environment in which methylation of neither the phage nor the host nucleic acid can occur. By superinfecting T3-infected cells with other phages, the latter can be obtained with methyl-deficient DNA. Although a great deal is known about the enzymology of the methylation reaction, and there appears to be a strong correlation between the in vitro and in vivo reactions, studies in which DNA is either supermethylated or totally unmethylated have not yielded any insight as to what the possible function of the methylated bases may be.


The enzymatic phosphorylation of nucleic acids and its application to end-group analysis. Polynucleotide kinase catalyzes the transfer of a phosphate group from ATP to the 5'-hydroxyl termini of polynucleotides. Selective labeling of the 5'-hydroxyl termini of DNA with polynucleotide kinase has been used to study the number and the identity of the 5'-terminal residues of bacteriophage DNA's, and to examine the nature of the phosphodiester bond cleavages produced by endonucleases and by sonic irradiation. The intact strands of T7 DNA bear 5'-phosphoryl end-groups; only deoxyadenylate and deoxythymidylate are present as 5'-terminal residues. The intact strands of native lambda-DNA bear 5'-hydroxyl end-groups. M13 DNA, a circular molecule, cannot be phosphorylated. End-group labeling of DNA provides a method for determination of molecular weight; calibration against other DNA preparations is not required. The molecular weight of a single strand of T7 DNA, determined by end-group labeling, is 13.1 x 10(6); the molecular weight of a single strand of lambda-DNA is 16.0 x 10(6). These values are in agreement with molecular weight estimates by sedimentation analysis and electron microscopy. Sonic irradiation of DNA has been shown to favor the production of polynucleotides terminated by 5'-phosphomonoester groups. All four deoxyribonucleotides are present as 5'-terminal residues of sonicated DNA.


Problems in protein biosynthesis.

Problems in protein biosynthesis. Outline of the steps in protein synthesis. Nature of the genetic code. The use of synthetic oligo- and polynucleotides in deciphering the code. Structure of the code: relatedness of synonym codons. The wobble hypothesis. Chain initiation and N-formyl-methionine. Chain termination and nonsense codons. Mistakes in translation: ambiguity in vitro. Suppressor mutations resulting in ambiguity. Limitations in the universality of the code. Attempts to determine the particular codons used by a species. Mechanisms of suppression, caused by (a) abnormal aminoacyl-tRNA, (b) ribosomal malfunction. Effect of streptomycin. The problem of "reading" a nucleic acid template. Different ribosomal mutants and DNA polymerase mutants might cause different mistakes. The possibility of involvement of allosteric proteins in template reading.


Amoebiasis in the African infant in Rhodesia.


Influence of social and economic research on public policy in the health field. A review.


Evaluating the quality of medical care.

Evaluating the quality of medical care.


Research into the organization of community health service agencies. An administrator's review.


Intranucleolar deoxyribonucleic acid components in insect cells as revealed by electron microscopy.


Requirement for ribonucleic acid synthesis for deoxyribonucleic acid replication in bacteria.


Heat denaturation of beta-galactosidase: a possible approach to the problem of catabolite repression and its site of action.


Suppression of homograft immunity in chickens grafted in ovo with allogeneic thymus.


Liver transplantation effects on plasma lipids.


Anti-ribonucleic acid factors in the sera of germ-free animals.


Spectrophotometric detection and measurement of sensitizing antibodies.


A simple dye test for skin graft viability.


Heterogeneity of rabbit serum interferons.


The significance of the cytoplasmic droplet in the disintegration of semen in Guernsey bulls.


The immunizing properties of a Staphylococcus aureus variant possessing surface antigen.


Identification of the protective and toxic antigens of Corynebacterium pseudotuberculosis.


The functional organization of the tryptophan gene cluster in Salmonella typhimurium.


The attachment of the male-specific bacteriophage F1 to sensitive strains of Escherichia coli.


Thymineless death and its relation to UV sensitivity in Escherichia coli.


On the regulation of cell division.

On the regulation of cell division.


On a class of noncommutative Jordan algebras.


Polysome transitions and the regulation of ribonucleic acid synthesis in Escherichia coli.


Translation of the genetic message: factors involved in the initiation of protein synthesis.


The effect of chlorambucil on proteases and esterases.


Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher's disease.


Recent advances in improving dry whole milk. A review.


The effect of intermittent positive pressure breathing and voluntary hyperventilation upon the distribution of ventilation and pulmonary blood flow to the lung in chronic obstructive lung disease.


Nutritional factors affecting the solids-not-fat content of milk.


Changes proposed for 12th Edition of Standard Methods for the Examination of Dairy Products.


Factors affecting ketogenesis from butyric acid in the ruminant.


The Warren Commission: Report and Hearings. A commentary on issues of importance in the study of investigation and  criminalistics.


Psychiatric observations on the Warren Commission Report.


A legal demurrer to the Report of the Warren Commission.


A critique of the medical aspects of the investigation into the assassination of President Kennedy.


Release and uptake of noradrenaline in adrenergic nerve granules.


Historical research, document examination and crown prince Rudolph of Austria.


Pharmaceutical sciences--1965. A literature review.


Statistical procedures for bioassays when the condition of similarity does not obtain.


Blood level distribution patterns of diazepam and its major metabolite in man.


Effects of thiols on escherichia coli beta-galactosidases.


Obituaries.

Obituaries.


Glycolytic and dehydrogenase activities of dwarf colony mutants Salmonella typhi and Salmonella typhimurium.


Increased proliferation of transplanted mouse bone marrow cells by pre-irradiation of the recipient.


Establishment of a line of mosquito (Aedes aegypti L.) cells grown in vitro.


Polypeptidyl-sigma-ribonucleic acid and amino-acyl-sigma-ribonucleic acid binding sites on ribosomes.


Cells producing IgD immunoglobulins in human spleen.


Experimental renal heterotransplantation. I. In widely divergent species.


A simple cannula for implantation into the chicken brain.


Allograft immunity and graft-versus-host activity in mice injected with sensitized spleen cells.


Transplantation immunity and hemagglutinin response in mice immunized with allogeneic skin grafts or splenic preparations.


The white blood cell response to skin homografts in mice.


Histocompatibility genes of mice. VI. Allografts in mice congenic at various non-H-2 histocompatibility loci.


Immunogenic properties of purified antigen preparations from a mouse sarcoma.


Acquired tolerance to skin grafts induced with cell-free antigenic material: further tissue sources, frozen storage, dose-duration requirements.


Effect of newborn splenectomy on homograft survival in inbred mice.


A unique instance of canine renal homotransplantation with remission of rejection crisis and prolonged survival.


Demonstration of isohistogenicity in groups of rats from partially inbred strains.


Fatigue in aviation activities.

Fatigue in aviation activities.


Dual actions of guanethidine on amine uptake mechanisms in adrenergic neurons.


A history of the pulmonary catarrhs and airways obstruction.


Historical note: fit or feign in the civil war.


Serologic types of Escherichia coli isolated from certain pigs with enteric disorders.


A review of recent sleep and dream studies.


Biochemical studies on the activity of thiophenicol.


Single disc method for minimum inhibitory concentration (MIC) determination.


The efficacy of clomiphene citrate for induction of ovulation. A controlled study.


Studies on two colonial types of Leptospira icterohaemorrhagia with special reference to the bottle culture method.


Survival of shell-frozen, freeze-dried, and agar slant cultures of Pasteurella multocida.


Effects of dextroamphetamine, pentobarbital, chlorphentermine, and placebo on the alpha blocking response in normal subjects.


Cryoprotective compounds. Review and discussion of structure and function.


Some effects of spermine on Escherichia coli.


Survival of Escherichia coli frozen in cell extracts.


Objective assessment of antitussive agents in patients with chronic cough.


Clinical investigation in drugs designed for prolonged release.


An unusual complication following replacement of the aortic valve by the Starr-Edwards prosthesis.


Surgical treatment of hiatal hernia, with particular reference to the transthoracic subdiaphragmatic approach.


Acute clinical assay for appetite suppression.


Corneal autografts.

Corneal autografts.


Is phenacetin the cause of "analgesic nephrotoxicity"?


Intermittent positive pressure ventilation in the treatment of severe crushing injuries of the chest.


Fixed pupil following keratoplasty. Evaluation of six cases.


Use of isocarboxazid in hypertensive patients.


Reticuloendothelial cell in the bone marrow and its relationship to iron metabolism.


Gentamicin in the treatment of bacterial conjunctivitis.


Acute conjunctivitis and moraxella.

Acute conjunctivitis and moraxella.


Controlling temporary spastic entropion.


History and development of photocoagulation.


Joseph Davis Eby (1887-1966).

Joseph Davis Eby (1887-1966).


Elucidation of body imagery in chronic schizophrenia.


Motivation for patient delay.

Motivation for patient delay.


The effects of LSD-25 on creativity and tolerance to regression.


Historical symposium. "The man who made surgery safe". Lister--the man.


Magnesium ion-independent ribonucleic acid depolymerases in bacteria. The distribution of ribonucleases among bacteria has been determined from the examination of a wide variety of species. Bacteria that had been growing rapidly on a solid medium were harvested, treated with acetone and incubated in the presence of EDTA between pH4 and pH9. The ribonuclease activity was determined from the rate at which acid-soluble nucleotides were released. Out of nearly 200 strains examined, about 30 did not contain a detectable ribonuclease. The pH optima of ribonucleases in the remainder were sufficiently distinctive to suggest a use in taxonomy. Escherichia coli B was examined in more detail to determine the factors responsible for variations in the ribonuclease content of this bacterium. Growth rate had little influence on ribonuclease content when a complex medium containing no readily assimilable carbohydrate was used; the addition of glucose resulted in a marked increase in ribonuclease and a dependence of enzyme content on growth rate. An increase in the concentration of sodium chloride in the medium decreased the ribonuclease content of bacteria growing on it.


History of Canadian surgery.

History of Canadian surgery.


Quantitative studies on isolated pancreatic islets of mammals. Activity and heterogeneity of lactate dehydrogenase in obese-hyporglycemic mice.


Soluble antigen fluorescent antibody test (SAFA) for human filariasis.


Effects of carbohydrates on the oxygen consumption of isolated pancreatic islets of mice.


A kinetic study of the bacteriolytic and bactericidal action of human serum.


Causal interpretations from cross-sectional data. An examination of the stochastic processes involved in the relationship between a personality characteristic and coronary heart disease.


Social class and coronary heart disease: a sociological assessment of the medical literature.


Antimicrobial therapy in patients sensitive to penicillin.


Causes of peptic ulcer. A selective epidemiologic review.


Experimental relapsing fever initiated by Borrelia hermsi. II. Sequential appearance of major serotypes in the rat.


Experimental relapsing fever initiated by Borella hermsi. I. Identification of major serotypes by immunofluorescence.


The influence of the route of administration of Newcastle disease virus on host response. 3. Immunofluorescent and histopathological studies.


Association of rapidly labelled bacterial RNA with ribosomal RNA in solutions of high ionic strength. II.


Myopathy with atypical mitochondria in type I skeletal muscle fibers. A histochemical and ultrastructural study.


Ulrich Ellenbog, one of Ramazzini's predecessors.


Salerno--something old, something new...


Liver enlargement and drug toxicity.

Liver enlargement and drug toxicity.


Steatonecrosis--Mallory body type.

Steatonecrosis--Mallory body type.


The transaminase tests in liver disease.


Pathogenesis of hemochromatosis.

Pathogenesis of hemochromatosis.


Malignant pelvic lymphomas.

Malignant pelvic lymphomas.


Abortion induced by means of the uterine aspirator.


Immunofluorescent study of B4 Coxsackievirus valvulitis in mice.


Direct localization and visualization of hyaluronate lyase activity by agar gel electrophoresis.


The susceptibility of Blastomyces dermatitidis to drying.


Response of the coyote to endotoxin.

Response of the coyote to endotoxin.


Exchange of injected labeled red cells in liver tissue during hemorrhagic shock.


Effects of cortisol and adrenalectomy on induction of interferon by endotoxin.


Instrumented identification for bacterial differentiation. A. The BAIT and TAMIS concepts. B. Immunoelectronic principles and instrumentation. SAM-TR-66-61.


Abnormal phosphorus metabolism in a potassium transport mutant of Escherichia coli. SAM-TR-67-10.


Recovery of clostridia from human feces. Development of a method. SAM-TR-66-81.


On the incidence of antinuclear factors in rheumatoid arthritis. A comparative study, with special reference to the reaction with polymorphonuclear granulocytes.


Pulmonic valvular insufficiency: etiology, recognition, and management.


The present status of clinical cardiac pacing.


Coxsackie B viral myocarditis and valvulitis identified in routine autopsy specimens by immunofluorescent techniques.


Magnesium requirements in adults.

Magnesium requirements in adults.


Central nervous system mechanisms mediating cardiac rate and rhythm.


Effect of pepsin on the absorption of food vitamin B12 and iron.


Accelerated oxidative catabolism of ascorbic acid in siderotic Bantu.


Formylation of amino acid analogues of methionine sRNA.


Brain ribosomes.

Brain ribosomes.


Microsurgery in ophthalmology.

Microsurgery in ophthalmology.


Blood platelet fluctuation consecutive to trauma and surgical intervention in the rat, a possible stress effect.


Our forgotten man. W. Marsden.

Our forgotten man. W. Marsden.


Clinical conference on leukemia. Chromosome studies in leukemia. This review discusses the significance of chromosomal abnormalities found in leukemia with the bias of belief that these have a primary role or are the mechanism of action of leukemogenic agents. The Philadelphia chromosome (Ph(1)) is present in marrow cells examined without culture at any stage of most patients with chronic granulocytic leukemia (CGL). the presence of this chromosome is of diagnostic and prognostic value.Varied chromosomal abnormalities have been found in acute leukemia. Each abnormality, which may be unique, is absent in remission, found again at relapse and is seldom changed by therapy. Abnormalities may be of number of chromosomes (aneuploid) or structural rearrangements resulting in "marker" chromosomes, Ranges of abnormal numbers of chromosomes, when present, usually have related patterns which suggest origin of several cell types from one initial cell. Cells from patients with increased risk of leukemia owing to genetic factors have a high incidence of chromosome breakage and structural rearrangements suggesting a mechanism for production of clones of abnormal, possibly leukemic, cells.


A controlled in-patient pilot study with the antidepressant mebanazine, a mono amine oxidase inhibitor of the hydrazine group. I.


Chronic obstructive disease of the major arteries of the upper extremity.


The infant's mouth.

The infant's mouth.


Dental significance of pathways for dissemination from infectious foci.


Excess minerals in the diet.

Excess minerals in the diet.


Effect of posterior thalamic lesions on retention of a brightness discrimination motivated by thirst.


Binding of specific sRNA to template ribosome complex: effect of proteolytic enzymes.


Regulation of lambda exonuclease. I. Properties of lambda exonuclease purified from lysogens of lambda T11 and wild type.


Radiophosphorus-induced single-chain interruptions in DNA.


Replication of secondary bacteriophage genomes in heterologous and homologous superinfections.


Inhibition of the synthesis of beta-galactosidase in Escherichia coli by 2-nitrophenyl-beta-D-fucoside.


Ribonucleic acid composition of bacteria as a function of growth rate.


Fractionation of viral-specific ribonucleic acid by cesium sulfate equilibrium density-gradient centrifugation.


Laboratory studies concerning the effectiveness and safety of various fluoride and fluoride-phosphate systems.


Prophylactic ampicillin in the control of intrauterine infection.


The effects of carphenazine, trifluoperazine and chlorpromazine on ward behavior, physiological functioning and psychological test scores in chronic schizophrenic patients.


Method for study of saliva and bacteria in dental enamel decalcification.


Dissimilarity between human and bacterial deoxyribonucleic acids.


Microbiological transformation of oxytetracycline.


Intracellular repressor of alkaline phosphatase.


Facial skeleton growth after bone grafting to surgically created premaxillomaxillary suture defects: an experimental study on the guinea pig.


A simplified method for correcting the prominent ear.


Split-skin graft covering lung, pericardium and diaphragm.


Interpreting muscle function in invertebrates.


Surgical treatment of ischial decubitus ulcers with buried derma-fat flap.


Sensory rehabilitation of the injured thumb.


The organization and function of the sarcoplasmic reticulum and T-system of muscle cells.


The closure of a wound of the lower leg in a patient with pemphigus vulgaris: a case report.


Cybernetic interactions in epigenetics.

Cybernetic interactions in epigenetics.


Genetic transcription or DNA-dependent RNA synthesis.


Technique of conversion and closure of postoperative septic wounds.


The effect of intra-arterial perfusion on renal function following acute ischemia.


Clinical study and results of stereoencephalotomy in the treatment of Parkinsonism.


An investigation of sectional aeronautical charts and series 200 charts as briefing aids for a side-looking radar reconnaissance task. AMRL-TR-66-153.


Bibliography and index of research in human and animal vigilance 1961-1965. Rep No. 456.


Adaptation, fortitude and intelligence.

Adaptation, fortitude and intelligence.


The infectivity of Plasmodium malariae to Anopheles labranchiae atroparvus in the first days of patency.


Analysis of the QRS vector loop in muscular dystrophy.


In vitro kidney storage. I. Hypothermia and hyperbaric oxygen.


John Edward Anderson: 1893-1966.

John Edward Anderson: 1893-1966.


Robert Arthur Kehoe, MD.

Robert Arthur Kehoe, MD.


The inhibition of streptococci by lactoperoxidase, thiocyanate and hydrogen peroxide. The oxidation of thiocyanate and the nature of the inhibitory compound. 1. The products of the lactoperoxidase-catalysed oxidation of thiocyanate by hydrogen peroxide were sulphate, carbon dioxide and ammonia. Cyanate, sulphite and a compound showing increased extinction at 235mmu (the ;235 compound') were intermediate oxidation products. 2. Two of the intermediates acted as electron acceptors in the oxidation of NADH(2). Thus NADH(2) was oxidized by sulphite in the presence of lactoperoxidase (EC 1.11.1.7) and Mn(2+) and by the ;235 compound' in the presence of an enzyme, the NADH(2)-oxidizing enzyme, present in extracts of lactoperoxidase-resistant streptococci. Sulphur dicyanide also acted as an electron acceptor in the latter reaction. The ;235 compound' was also reduced non-enzymically by sulphite. 3. The glycolysis of lactoperoxidasesensitive streptococci suspended in glucose solution was not inhibited by sulphite, cyanate, cyanide or the ;235 compound' but was inhibited by sulphur dicyanide. The inhibition by 0.1mm-sulphur dicyanide could be reversed, as could that caused by lactoperoxidase, thiocyanate and hydrogen peroxide, by washing the cells or by the addition of a cell-free extract of a lactoperoxidase-resistant streptococcus. 4. The effects of 0.1mm-sulphur dicyanide on catabolic enzymes of resting streptococci were very similar to those of the lactoperoxidase-thiocyanate-hydrogen peroxide system. Thus hexokinase was completedly inhibited, glucose 6-phosphate dehydrogenase and aldolase were partially inhibited and phosphohexokinase was little affected in both cases.


Catabolite repression of beta-galactosidase synthesis in Escherichia coli. 1. Repression by glucose of beta-galactosidase synthesis is spontaneously reversible in all strains of Escherichia coli examined long before the glucose has all been consumed. The extent of recovery and the time necessary for reversal differ among various strains. Other inducible enzymes show similar effects. 2. This transient effect of glucose repression is observed in constitutive (i(-)) and permease-less (y(-)) cells as well as in the corresponding i(+) and y(+) strains. 3. Repression is exerted by several rapidly metabolizable substrates (galactose, ribose and ribonucleosides) but not by non-metabolized or poorly metabolized compounds (2-deoxyglucose, 2-deoxyribose, phenyl thio-beta-galactoside and 2-deoxyribonucleosides). 4. The transient repression with glucose is observed in inducible cells supplied with a powerful inducer of beta-galactosidase synthesis (e.g. isopropyl thio-beta-galactoside) but not with a weak inducer (lactose); in the latter instance glucose repression is permanent. Diauxic growth on glucose plus lactose can be abolished by including isopropyl thio-beta-galactoside in the medium. 5. In some strains phosphate starvation increases catabolite repression; in others it relieves it. Adenine starvation in an adenine-requiring mutant also relieves catabolite repression by glycerol but not that by glucose. Restoration of phosphate or adenine to cells starved of these nutrients causes a pronounced temporary repression. Alkaline-phosphatase synthesis is not affected by the availability of adenine. 6. During periods of transient repression of induced enzyme synthesis the differential rate of RNA synthesis, measured by labelled uracil incorporation in 2min. pulses, shows a temporary rise. 7. The differential rate of uracil incorporation into RNA falls during exponential growth of batch cultures of E. coli. This is equally true for uracil-requiring and non-requiring strains. The fall in the rate of incorporation has been shown to be due to a real fall in the rate of RNA synthesis. The significance of the changes in the rate of RNA synthesis is discussed. 8. A partial model of catabolite repression is presented with suggestions for determining the chemical identification of the catabolite co-repressor itself.


The control mechanism of thiamine biosynthesis a model for the study of control of converging pathways. 1. Thiamine or the pyrimidine moiety of thiamine added in excess to a growing culture of Salmonella typhimurium LT2 repressed subsequent thiamine synthesis in non-growing organisms. 2. A mutant unable to convert added pyrimidine moiety into thiamine was not repressible by the pyrimidine, showing that thiamine, not the pyrimidine, was the repressor. 3. Thiamine repression occurred at 40mmug. of thiamine/mg. dry wt. or above and de-repression occurred at 30mmug. of thiamine/mg. dry wt. or below. 4. Thiamine controlled the pyrimidine and thiazole pathways at the same concentration and to the same extent. 5. Biosynthesis of the thiazole moiety had, in contrast with biosynthesis of the pyrimidine moiety, an additional feedback inhibition control that allowed utilization of the exogenous thiazole. 6. The enzymes joining the pyrimidine and thiazole moieties were repressible by high concentrations of thiamine. 7. Thiamine was rapidly converted into thiamine pyrophosphate and this appeared to be the active repressor. 8. Theoretical aspects of control of converging pathways are discussed.


The renaturation of soluble collagen. Products formed at different temperatures.


Size distribution of thoracic duct lymph chylomicrons from rats fed cream and corn oil.


Occult spinal dysraphism.

Occult spinal dysraphism.


The de-repression of thiamine biosynthesis by adenosine a tool for investigating this biosynthetic pathway. 1. Growth of Salmonella typhimurium LT2 in the presence of adenosine was shown to cause enormous synthesis of thiamine in washed-cell suspensions. 2. Evidence that this was due to de-repression and not an accumulation of precursors was obtained by using a mutant blocked in the biosynthesis of the thiazole moiety, which showed a similarly large synthesis of the pyrimidine of thiamine. 3. The specific requirements for a source of energy, nitrogen and sulphur were investigated, and indicated new synthesis in this system.


Association between colicinogenic and fertility factors.


Transduction of Salmonella typhimurium-Salmonella montevideo hybrids.


A model for three-point analysis of random general transduction.


The effect of a bacterial mutator gene upon mutation rates in bacteriophage T4.


Intranuclear 3H thymidine: dosimetric, radiobiological and radiation protection aspects.


Techniques and procedures for in vitro and in vivo rumen studies.


Restriction in matings of Escherichia coli strain K-12 with strain B.


Optical specificity of monoamine oxidase.


Effect of methylhydrazine derivatives on the survival of second-set skin homografts.


Enhanced susceptibility of thymectomized and irradiated mice to infection with Mycobacterium leprae.


Flagella-assisted cell fission in Escherichia coli.


Immunofluorescent staining of globule leucocytes in the colon of the sheep.


The physiology of excystment of the metacercaria of Fasciola hepatica L.


Increased stability of polysomes in an Escherichia coli mutant with relaxed control of RNA synthesis.


Evidence for increased DNA template activity in regenerating liver nuclei.


Analysis of products of protein synthesis directed by R17 viral RNA.


In vitro formation of functional ribosomes from the "relaxed particles".


Template functions in the enzymic formation of polyribonucleotides, I. Integrity of the DNA template.


Studies of missense suppression of the tryptophan synthetase A-protein mutant A36.


Missense suppression of the tryptophan synthetase A-protein mutant A78.


Sensory deprivation and aberrant behavior among idiots.


The main thoracic and cervical arteries of birds. 2. Columbiformes, Columbidae, 2.


Anterior grafting in extensive spondylolisthesis.


General metabolism of the hexapod embryo with particular reference to lipids.


Correlation between activity of the visual cortex and the somatovisual interaction in the lateral thalamus of cats.


Lesions of infectious arthritis in calves.


Studies on soluble cytochromes in Enterobacteriaceae. I. Detection, purification, and properties of cytochrome c-552 in anaerobically grown cells.


Effect of ultrasound on disaggregation of milk bacteria.


Milk enzymes: their role and significance.


Distribution of lipase among components of a water extract of rennet casein.


Cause of microbial death during freezing in a soft-serve ice cream freezer.


Comparison of Mosaic response of Negro and white primary-school children.


Some methodological considerations in physiological research on aversive behavior.


Fluorinated pyrimidines. 28. The synthesis of 5-trifluoromethyl-6-azauracil and 5-trifluoromethyl-6-aza-2'-deoxyuridine.


Specificity of sRNA for recognition of codons as studied by the ribosomal binding technique.


Transposition of the lac region of Escherichia coli. I. Inversion of the lac operon and transduction of lac by phi80.


Selective synthesis of T-even bacteriophage early messenger in vitro.


Transposition of the lac region of Escherichia coli. II. On the role of thiogalactoside transacetylase in lactose metabolism.


Positive contrast cerebral ventriculography using water-soluble media. Clinical evaluation of 102 procedures using methyglucamine iothalamate 60 per cent.


New species of Dactylogyrinae from Alabama fishes.


Personality assessments conceptualized as perspectives.


Common psychological tests applied to the assessment of brain damage.


Body image in Hansen's disease patients.


The assessment of anxiety of means of the Rorschach.


Stereotypical M-F as related to two Szondi test assumptions.


The imaginary lovers delusion: a diagnostic case study.


The living, endogenous stages of the rat coccidium, Eimeria nieschulzi.


"Spheroplasts" prepared from Euglena gracilis by proteolysis.


A note on the mechanism of UV mutagenesis in Escherichia coli.


The eighth Welbeck memorial lecture. Equipment and people.


Granville Pattison and the uses of history.


Clinical aspects of glucose-6 phosphate dehydrogenase deficiency.


The application of bronchostomy to the experimental study of transplanted pulmonary tissue.


Derepression of oxaloacetate 4-carboxy-lyase synthesis in Salmonella typhimurium.


Ribonucleic acid synthesis by Escherichia coli C 3000/L after infection by the ribonucleic acid coliphage ZIK/1, and properties of the coliphage-induced double-stranged ribonucleic acid. 1. The efficiency of extracting nucleic acids from Escherichia coli after five methods of obtaining cell lysis was determined. 2. The recovery of various nucleic acid species isolated after chromatography on methylated albumin-coated kieselguhr was also examined. 3. Double-stranded coliphage-induced RNA was isolated from infected bacteria and its resistance to ribonuclease digestion under various conditions determined. 4. The involvement of double-stranded RNA during the infection process was demonstrated. 5. The time-course of the syntheses in infected cells of double-stranded RNA, DNA, single-stranded coliphage and 16s ribosomal RNA, transfer RNA and ribosomal 23s RNA was examined. 6. It was demonstrated that the syntheses of DNA, transfer RNA and ribosomal RNA decreased 10-15min. after infection. 7. Synthesis of coliphage RNA commenced 10-15min. after infection and double-stranded RNA was also synthesized from about 10min. after coliphage adsorption.


Electron microscopy of alkaline phosphatase of Escherichia coli.


Direct testing of antibiotic sensitivity by a microcolony method.


A rapid determination of bacterial antibiotic sensitivity in mixed culture.


Selenite reduction by Salmonella heidelberg.


Effects of vegetable tannins on glucose oxidation by various microorganisms.


A clinical trial of four hypnotic drugs. A CLINICAL TRIAL OF FOUR HYPNOTIC DRUGS WAS CARRIED OUT: Ro 4-5360, 10 mg. (Mogadon), methyprylon, 200 mg. (Noludar), Ro 4-5360, 5 mg. (Mogadon), secobarbital sodium, 100 mg. (Seconal), and a placebo. The study was on the usual double-blind basis, and all observations were made by a full-time nurse. Capsules were given at 10 p.m. for five successive nights, with two nights free from medication or observation. There were five such periods. The nurse carried out her observations right through the night, determining whether the patients were awake or asleep. Each of these drugs was statistically significantly different from the placebo, in terms of length of sleep. Differences between the individual drugs were not significant. The length of action of the various drugs appeared to be similar, with a somewhat longer period of activity for the Mogadon in both dosages. The major side effect was some drowsiness: this was more marked with Mogadon 10 mg. With the hypnotics, the patients had, on the average, about one hour more sleep than on the placebo.


An isotope dilution method for determining the absolute amounts and specific activities of proline and hydroxyproline in tissues.


Effect of sodium acetate on TmPAH depressed by exposure to hydrazine.


Current malaria control problems and research.


Lattice structures in human tumor cells as revealed by electron microscopy.


Studies on two variant strains of Yoshida sarcoma characterized by island formation in ascites.


Substrate-accelerated death' of nitrogen-limited bacteria.


Regression of mouse ascites tumors by the treatment with bacterial extracts.


Virological studies on experimental infection of pregnant mice with influenza virus.


Diffuse pulmonary diseases.

Diffuse pulmonary diseases.


Psychosomatic methods of preparation for childbirth. Spread of the methods, theory, and research.


The central nervous system and disorders of ovulation in women.


Treatment of pyelonephritis in pregnancy.


Corticosteroids in pulmonary tuberculosis. II. Importance of background factors.


Corticosteroids in pulmonary tuberculosis. 3. Indications.


Jaroslav Heyrovský, 1890-1967.

Jaroslav Heyrovský, 1890-1967.


Enzymic assay for spermine and spermidine.


Optics and visual physiology.

Optics and visual physiology.


Phrenic and cardiac irregularities in the hypothermic cat.


Partial hepatic autotransplantation with complete revascularization in the dog.


Prevention of ventricular fibrillation during experimental hypothermia. Failure of sodium diphenylhydantoin.


Auxiliary pancreas allografting.

Auxiliary pancreas allografting.


Hemorrhagic necrosis in pancreas allografts.


Radiation clearance of bone. The préliminary report.


Renal preservation with hyperbaric oxygenation and hypothermia.


The localization of antigen in lymph nodes and its relation to specific antibody-producing cells. II. Comparison of iodine-125 and tritium labels.


The localization of non-microbial antigens in the draining lymph nodes of tolerant, normal and primed rabbits.


Molecular weight and amino acid composition of human gastricsin and pepsin.


Isolation of "renaturable" transfer ribonucleic acids.


Hydrolysis of S-substituted monoesters of phosphorothioic acid by alkaline phosphatase from Escherichia coli.


Effect of lesions in the central nervous system on lateral hypothalamic self-stimulation in the rat.


Spontaneous alternation and septal lesions.


Increased serum glutamic-oxalacetic transaminase and lactic dehydrogenase levels produced by cholera infection and cell-free toxin in the rabbit.


The effects of artificial ventilation on cerebrospinal fluid pressure.


Single plane fixation for prosthetic aortic valves.


Some basic psychologic investigations relevant to schizophrenia.


Assessing the emotional development of children.


Cutaneous complications in subaponeurotic surgery of the communicating venous system.


Observations on "dense-body" structure in nerve cells with special reference to scrapie.


Studies on growth products of Corynebacterium ovis. II. Other activities and their relationship.


AF Hospital renamed to honor General Grant.


An analysis of fevers of unknown origin in American soldiers in Vietnam.


Edward L. Ball, D.D.S.

Edward L. Ball, D.D.S.


A case of congenital paresis in 1966.

A case of congenital paresis in 1966.


Prevalence of periodontal disease in hospitalized populations.


High-dose corticoid therapy in Hodgkin's disease and other lymphomas.


An investigation into the use of the dynamic method of calibration of cardiac output.


Anaesthesia in untreated myxoedema. Report of two cases.


Effect of oral iron therapy on the symptoms of anaemia.


Arterial gas tensions under anaesthesia in tetralogy of Fallot.


Periodontal disease in diabetics.

Periodontal disease in diabetics.


An evaluation of sulfasymazine in infections in mice.


Aspects of births in the Shatby Hospital, Alexandria.


Homograft response and haemagglutinin production by sensitized thymectomized irradiated adult mice.


Induction of experimental amyloidosis in neonatally thymectomized mice.


Naturally occurring anti-tissue antibodies in rat sera.


The knotless suture method for prosthetic valve fixation.


Clinical and experimental studies on the pathogenesis of cholecystitis.


The present status of organ transplantation. A review.


Samuel D. Bell (1892-1966).

Samuel D. Bell (1892-1966).


John M. Sheldon (1905-1967).

John M. Sheldon (1905-1967).


Evaluation of B.663 in human leprosy.

Evaluation of B.663 in human leprosy.


A logarithmic index of bacilli in biopsies. I. Method.


Synthesis of macromolecules by Escherichia coli near the minimal temperature for growth. When a culture of Escherichia coli ML30 growing exponentially at 37 C in a glucose minimal medium was shifted abruptly to 10 C, growth decreased for about 4.5 hr. There was no net synthesis of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein. The cells, however, respired at a rate characteristic of cells growing in the steady state at 10 C and were able to accumulate alpha-methyl-d-glucoside. When growth recommenced at 10 C, protein synthesis started at 4 hr, RNA synthesis, with a burst at 6 hr, and DNA synthesis, with a burst at 7 hr. One synchronous division occurred at about 11 hr after shifting to 10 C. There was no alteration in the steady-state RNA to protein ratio. The results are discussed in relation to other reported effects of shifts in environmental conditions. The lag at 10 C was dependent on prior conditions of growth at 37 C. Growth at 37 C under conditions giving catabolite repression were necessary for the lag to be established on shifting to 10 C.


Division delay induced in Escherichia coli by near-ultraviolet radiation. Beams of near-ultraviolet radiation at several principal emission lines of a mercury arc were isolated with a grating monochromator and directed upon cell suspensions. During subsequent incubation at room temperature in Nutrient Broth, the population was studied by removing samples and obtaining cell numbers and cell size distributions with an electronic cell counter. Division delay without lethality was observed. The shapes of the dose-response curves for induction, the doses of near-ultraviolet radiation required, and the action spectrum for division delay were found to be similar to those for growth delay (in broth) and for photoprotection. These findings indicate that all three effects, division delay, growth delay, and photoprotection, are induced by a common type of critical event. Changes in cell size distribution in the culture during incubation in Nutrient Broth after near-ultraviolet irradiation are very similar for control and irradiated populations, although these changes occur at a much later time in the irradiated population. This indicates that, in Nutrient Broth, the population recovers completely from the inhibition of growth and division, thus justifying use of the term "delay," and suggesting that the damage is nongenetic.


Clinical evaluation studies in lepromatous leprosy. Sixth series: effect (on lepra reaction) of supplementing DDS with dexamethasone, methandrostenolone, or mefenamic acid.


Isolation and characterization of Actinomyces propionicus. Three cultures of Actinomyces have been identified as Actinomyces propionicus. Two of these strains are recent isolates, one, 427, from a case of cervico-facial actinomycosis, and one, 439, from a case of lacrimal canaliculitis. The third strain, 346, was described by F. Lentze as A. israelii serological type II. These three strains were compared with the type strain of A. propionicus ATTC 14157 and with known strains of five other Actinomyces species. Morphologically and biochemically the three new cultures of A. propionicus were identical with the type strain but closely resembled A. israelii. In serological tests making use of fluorescent antibody, all four A. propionicus strains gave negative results with antisera for A. israelii, A. bovis, A. naeslundii, and A. eriksonii, but gave positive results with antisera for A. propionicus 14157 and strain 346. The A. propionicus antisera did not stain other Actinomyces species. A. propionicus contains diaminopimelic acid (DAP) in its cell wall and produces propionic acid from glucose. All three new isolates were shown to contain DAP and to produce propionic acid. By use of the presence of DAP in the cell wall and serological tests as the differential criteria, the three cultures described in the report were specifically identified as A. propionicus.


Growth of the fission yeast, Schizosaccharomyces pombe, with late, eccentric, lytic fission in an unbalanced medium. Growth of Schizosaccharomyces pombe in batch cultures in a commercial defined medium was found to be normal until the last generation before the stationary phase. Approximately one-half the progeny of the last division lysed. Lysis occurred at breaks in the cell wall at cell-plates whose fission was eccentric. Normal culture cycle patterns were obtained when the medium was balanced by addition of either 0.20 mg of l-asparagine per ml or 5.0 mg of KH(2)PO(4) per ml, or both. The lytic effect of growth in the unbalanced medium was compared with similar effects of growth in 2-deoxyglucose. These studies with 2-deoxyglucose in the balanced medium confirmed earlier cytological observations (lysis at all growing points), but showed that the similarities were superficial.


Chemotherapeutic trials in leprosy. 4. Dapsone (DDS) in low dosage in the treatment of lepromatous leprosy. A demonstration pilot study.


Amino acid composition of crystalline botulinum toxin, type A.


Protein synthesis in sonically damaged Escherichia coli. By gentle sonic treatment, Escherichia coli cells were modified to permit penetration of actinomycin D, adenosine triphosphate, trypsin, ribonuclease, and polyuridylic acid. The behavior of these "soniplasts" as protein-synthesizing particles was investigated.


A logarithmic index of bacilli in biopsies. 2. Evaluation.


Lipoic acid requirement of Mycoplasma species abian strain J.


Studies on Mycobacterium leprae in media enriched by mycobacterial extracts.


Mutator gene of Escherichia coli B.

Mutator gene of Escherichia coli B. An azaserine-resistant derivative of Escherichia coli B/UV, AZA/R(1), was found to carry a mutator gene. This gene, designated mutS1, was mapped by means of conjugation and P1kc-mediated transduction. The mutS1 gene was cotransduced with argB at a frequency of 2.4%; the gene order in this region of the chromosome is thy argB mutS1. To determine whether a relationship commonly exists between azaserine resistance and the mutator property, 12 additional azaserine-resistant derivatives of B/UV were developed and tested for the mutator phenotype. None of the twelve was a mutator strain. The level of azaserine resistance was not increased over that of the recipient parent when mutS1 was transduced to an azaserine-susceptible strain. Reversion studies indicated that mutS1 induced adenosine-ribosylthymine to guanosine-cytidine and guanosine-cytidine to adenosine-ribosylthymine transitions. Because such mutational changes are suppressible with deoxynucleosides when induced by base analogues, an attempt was made to suppress the mutator activity of mutS1 by the addition of deoxyribonucleosides to the medium. No suppression was found. Recombinants were prepared containing mutS1 and the Treffers mutator gene of E. coli K-12. The effect of the mutator genes appears to be additive.


Derepression of alkaline phosphatase in  Escherichia coli by p-fluorophenylalanine. p-Fluorophenylalanine (FPA) causes a 100-fold increase in alkaline phosphatase in Escherichia coli B, strain PR1 at 30 C in minimal medium that contains excess inorganic phosphate (1.92 x 10(-3)m). Little increase in alkaline phosphatase synthesis occurs under these conditions at 22 C. [This strain is known to have a mutation in a regulator gene (R(2)) that, in the absence of FPA, permits derepression of alkaline phosphatase synthesis at 37 C, but not at 30 C or below.] In contrast, E. coli B3 (the strain from which E. coli B strain PR1 was derived) is not derepressed at 30 C by FPA. (14)C-FPA is incorporated into bacterial proteins. Temperature-shift experiments (30 Cright harpoon over left harpoon22 C) in the presence of FPA are consistent with the following mechanism. FPA is incorporated into the genetically altered R(2) protein at 30 and 22 C. This further alteration due to the incorporation of analogue makes the R(2) protein inactive at 30 C, but active at 22 C.


David Keilin, 1887-1963.

David Keilin, 1887-1963.


Bacterial survival in suspension in polyethylene glycol solutions.


The survival of Escherichia coli in nitrogen atmospheres under changing conditions of relative humidity.


Automatic control of dissolved oxygen concentration in stirred microbial cultures.


The relationship of F type piliation and F phage sensitivity to drug resistance transfer in R+F- Escherichia coli K 12.


Biochemical studies of lethal processes in aerosols of Escherichia coli.


Morphological features of the pili associated with Escherichia coli K 12 carrying R factors or the F factor.


Biological application of immunologic techniques in electron microscopy.


Richard B. Stoughton, M.D.

Richard B. Stoughton, M.D.


Host specificity of DNA produced by Escherichia coli. 9. Host-controlled modification of bacteriophage fd.


The establishment of beta-galactosidase repression in the mating system of Escherichia coli K12.


Inhibition of repressor formation in the lactose system of Escherichia coli by inhibitors of protein synthesis.


Control of messenger RNA synthesis and decay in Escherichia coli.


Perpetuation of genome of a temperature-sensitive mutant of RNA bacteriophage beta in growing cells of Escherichia coli at high temperature.


Electrophoretic properties of enzymically synthesized DNA.


Enzymic synthesis of RNA from T7 DNA.

Enzymic synthesis of RNA from T7 DNA.


Specific stimulation of RNA synthesis by methionine in several strains of Escherichia coli.


Effects of ultraviolet light on polyuridylic acid assayed in vitro.


Regulatory mechanisms and protein synthesis. X. Codon recognition on 30 S ribosomes.


Subunit structure of the tryptophan synthetase of Escherichia coli.


Dissociation of ribonucleic acid from silkmoth pupae by heat and dimethylsulfoxide: evidence for specific cleavage points.


The binding of RNA polymerase to DNA.

The binding of RNA polymerase to DNA.


Pulmonary hazards from exposure to glass fibers.


Drug effects on animal performance and the stress syndrome.


Sulphur metabolism: the usefulness of N-ethylmaleimide.


Effect of disseminated lupus erythematosus sera on the respiratory activity of guinea-pig leucocytes.


Monovalent cation requirement for the aminoacyl transfer reaction in protein synthesis.


Determination of regional blood flow by means of small semiconductor detectors and red cells tagged with phosphorus-32.


Modification of poor growth of parental marrow cells in F1 hybrid mice.


Dr.

Dr.


A multipurpose, modular respiratory monitor for intensive care units using intermittent positive-pressure respiration.


The earliest medical electrician in South Africa.


Health, population, and economic development. International health programs have an important role in promoting economic development and population control. Health as a basic human value is particularly important to people in the developing world. Rates of economic development lower than had been hoped for and ever more steeply rising population growth have precipitated a reaction against public health programs. Among economists, agriculturalists, and even health professionals the philosophy arose that one should "hold back" on using modern weapons against disease because they are "too effective." To satisfy the recognized popular demand, simple and relatively ineffective measures of curative medicine could be substituted. It was said that the emphasis should be, instead, on agriculture, community development, education, and industrialization and that family planning should be pushed as a separate program. Documentation presented here sharply challenges such a point of view. No segment of the total development process can be effective without the other sectors.


Replication of viral RNA: RNA synthetase from Escherichia coli infected with phage MS2 or Qb. An RNA synthetase is formed in Escherichia coli after infection with bacteriophages containing RNA. Specific annealing techniques revealed that, from the very outset of the reaction in vitro, the partially purified enzyme-template complex synthesizes parental-type plus strands, namely, MS2-RNA when isolated from cells infected with MS2 phage and Q(beta)-RNA in the case of cells infected with Q(beta) phage. This is in contrast to the situation found with Q(beta) replicase primed with Q(beta)-RNA, where the initial product is the complementary strand.


Experimental platelet thrombus.

Experimental platelet thrombus.


Rôle of platelets in thrombosis.

Rôle of platelets in thrombosis.


Inhibition of thrombogenesis by inhibition of platelet aggregation.


Experimental coagulation thrombus.

Experimental coagulation thrombus.


Rôle of coagulation in thrombosis.

Rôle of coagulation in thrombosis.


The rôle of lipids in thrombosis.

The rôle of lipids in thrombosis.


Contribution to the morphology of thrombosis.


The pharmacological basis of oral anticoagulant therapy.


Anticoagulant therapy in acute myocardial infarction.


Treatment of cerebral arterial thromboembolism and hemorrhage.


The pathology of arterial thrombosis.

The pathology of arterial thrombosis.


Coagulation disturbance induced by Echis colorata venom in vivo.


The vascular wall in the pathogenesis of thrombosis.


Hemodynamic factors in the pathogenesis of thrombosis.


Haemostasis and thrombosis.

Haemostasis and thrombosis.


Surgery and Lister.

Surgery and Lister.


Prospects for a vaccine against group A streptococci: the problem of the immunology of M proteins.


A trial of streptonigrin in the treatment of advanced malignant disease.


St. Christopher's Hospice.

St. Christopher's Hospice.


Evidence for anti-Burkitt tumour globulins in Burkitt tumour patients and healthy individuals.


Sir Alexander Macgregor.

Sir Alexander Macgregor.


Live donors for renal transplantation.

Live donors for renal transplantation.


Somerville Hastings.

Somerville Hastings.


Augmentation of artificial circulation during cardiopulmonary resuscitation.


Multiclinic trials in cancer chemotherapy.


Methodology of multiclinic therapeutic trials in hypertension.


The control of unknown variables.

The control of unknown variables.


A theoretical examination of double-blind design.


The changing voice of protest.

The changing voice of protest.


Pulmonary and 'central' blood volume during reactive hyperaemia in the legs.


Polarization impedance of stainless steel bipolar electrodes in brain.


Ethical views of Harry Stack Sullivan.

Ethical views of Harry Stack Sullivan.


Psychophysiological reactions to films by chronic schizophrenics. I. Effects of drug status.


Measurement of indocyanine green dye with a cuvette oximeter.


Role of platelets in the acute pulmonary responses to endotoxin.


Recent modifications of the glycol methacrylate embedding procedure.


Decentering implications of social interactions.


The ultrastructure and spatial organization of the metaphase kinetochore in mitotic rat cells.


The effects of colcemid inhibition and reversal on the fine structure of the mitotic apparatus of Chinese hamster cells in vitro.


Effects of Medicare and Title XIX on House-Staff Training Programs.


Recognition and management of smoke inhalation.


George R. Murray (1865-1939). Clinical endocrinologist.


Fibrinolysis: an unusual cause of bleeding.


Primary hyperparathyroidism.

Primary hyperparathyroidism.


Hyperfunctioning adrenocortical diseases.


Steroid synthesis by the human ovary: a compartmental viewpoint.


Unusual manifestations of Graves's disease.


Acute renal failure: its unusual causes and manifestations.


A. T. Glenny.

A. T. Glenny.


The morphology of temperate bacteriophages of Serratia marcescens.


General Douglas Macarthur.

General Douglas Macarthur.


Clinical virology today.

Clinical virology today.


Management of chloroquine resistant falciparum malaria.


Factors influencing host resistance to salmonella infection. The effects of hemolysis and erythrophagocytosis.


Memorial. Arthur Frederick Miller, M.D.

Memorial. Arthur Frederick Miller, M.D.


Osler, Trollope and the fixed period.

Osler, Trollope and the fixed period.


Memorial. Charles C. Wolferth, M.D.

Memorial. Charles C. Wolferth, M.D.


The Gordon Wilson lecture: growth hormone--1966.


Splenic pooling and the pathophysiology of hypersplenism.


Memorial. John Charles Leonard, M.D.

Memorial. John Charles Leonard, M.D.


Memorial. Walter B. Martin, M.D.

Memorial. Walter B. Martin, M.D.


Memorial. Henry Bearden Mulholland, M.D.


Memorial. Charles Nash Meader, M.D.

Memorial. Charles Nash Meader, M.D.


Memorial. George William Norris, M.D.

Memorial. George William Norris, M.D.


Memorial. Samuel Timothy Nicholson, 2nd., M.D.


Memorial. George Morris Piersol, M.D.

Memorial. George Morris Piersol, M.D.


Memorial. Henry M. Thomas, M.D.

Memorial. Henry M. Thomas, M.D.


Memorial. Roger Irving Lee, M.D.

Memorial. Roger Irving Lee, M.D.


Memorial. Roy Delaplaine Adams, M. D.

Memorial. Roy Delaplaine Adams, M. D.


Lewis John Pollock, Md. 1886-1966.

Lewis John Pollock, Md. 1886-1966.


Isolation and properties of a DNA-containing rod-shaped bacteriophage.


Control of ribonucleic acid synthesis in Escherichia coli cells with altered transfer ribonucleic acid concentration.


Loss of coding properties of the trinucleotide guanylyl-uridylyl-uridine on replacement of uridylic by dihydrouridylic acid.


Function of reticulocyte ribonucleic acid in the Escherichia coli cell-free system.


On the mechanism of action of chloramphenicol in protein synthesis.


The isolation of ribonucleic acid from plant, bacterial or animal cells.


Progressive subcortical gliosis, a rare form of presenile dementia.


Asbestosis.

Asbestosis.


Myelopathy complicating congenital atlanto-axial dislocation. (A study of 28 cases).


Early maxillary orthopedics: a sequence of events.


Inhibition of protein synthesis by bottromycin A2 and its hydrazide.


Mechanism of kasugamycin action on polypeptide synthesis.


Sydney Wood Bradley 1879-1967.

Sydney Wood Bradley 1879-1967.


Onset of function in the human fetal thyroid: biochemical and radioautographic studies from organ culture.


A new technique of partial nephrectomy.

A new technique of partial nephrectomy.


William Hawkins Wilson--a biographical sketch (1868-1956).


The lymphocyte.

The lymphocyte.


A comparative trial of amitriptyline and trimipramine in the treatment of depression.


Effect of temperature on s-ribonucleic acid aggregation induced by magnesium ions.


Cobalt-free corrinoids as vitamin B12 antagonists.


Rapid method for localizing beta-glucuronidase in populations of human leucocytes and of mouse Ehrlich carcinoma cells.


Meiosis in pupal ovarian cells of Samia cynthia cultured in vitro.


Structure in protein films: myosin monolayers.


Fluorescent complement fixation technique.


Immunological priming without production of circulating bacterial antibodies conditioned by endotoxin and its lipoid A component.


Fluorescence microscopy of lysosomes and related structures in living cells.


Methods for the preparation of autoradiographs with coverslip cultures.


Mathematical approach to the spread of scientific ideas--the history of mast cell research.


Loss of dendrite spines as an index of pre-synaptic terminal patterns.


Distinction of brown from white adipose tissue.


Effect of thrombin, adenosine diphosphate, connective tissue, and endotoxin on platelet glycolysis.


Lysosome stabilizing agents for hypothermic kidney preservation.


Reconstruction in vivo of irradiated Escherichia coli deoxyribonucleic acid; the rejoining of broken pieces.


Depressant action of cyanide on recombination and synthesis of deoxyribonucleic acid in phage T4-Escherichia coli complexes.


New types of immunity to virulent T-phages in Escherichia coli.


Bertram David Lewin. An appreciation.

Bertram David Lewin. An appreciation.


Bibliography of Bertram D. Lewin (1926-1966).


Theories of transference neurosis.

Theories of transference neurosis.


The nonsense of Edward Lear.

The nonsense of Edward Lear.


Robert Palmer Knight, 1902-1966.

Robert Palmer Knight, 1902-1966.


A new infant resuscitation shelf.

A new infant resuscitation shelf.


Body attention patterns and personality defenses.


Genetic recombination in Escherichia coli: clone heterogeneity and the kinetics of segregation. Several recombinant types may be produced from a single Escherichia coli zygote when the donor parent is Hfr-Hayes and segregation is delayed; usually only one type is produced with Hfr-Cavalli. Statistical experiments confirm well-known pedigree analyses by micromanipulation and suggest that DNA synthesis is required before final genetic integration.


Delayed hypersensitivity: bone marrow as the source of cells in delayed skin reactions. Adult Lewis rats were thymectomized, irradiated, and restored with bone marrow from allogeneic (or F(1)) donors. They were passively sensitized to tuberculin by a subsequent transfer of Lewis lymph node cells and were given intradermal skin tests with tuberculoprotein. In 24-hour skin reactions the majority of cells, in successive experiments, were shown to be allogeneic (or F(1)) with the use of isoantibody against the antigens of the transplanted marrow cells and by the indirect fluorescent antibody technique. Our results demonstrate that the non-specific cells making up a large proportion of the infiltrating elements in tuberculin skin reactions probably originate in the bone marrow.


A rapid method for obtaining zygotes and to determine the mating type in Saccharomyces.


Cell and tissue culture in aging research.


Aging of ground substance in connective tissue.


Somatic mutations and the aging process.


The biology and pathogenesis of vascular disease.


Lipid peroxidation: its measurement, occurrence, and significance in animal tissues.


The metabolism of ribonucleic acid in young and old rodents.


Regulation and deterioration of structure in membranes.


Controlled trials of a sulphonamide given weekly to prevent exacerbations of chronic bronchitis.


Acute metabolic response to human growth hormone in different types of dwarfism.


Treatment of radiation sickness with pyridoxine hydrochloride in outpatients of a radiotherapy unit.


The effect of insulin on the distribution space of galactose in eviscerated normal and diabetic rats and their selected organs.


The surgery of facial malignancy. A conservative approach.


Facial nerve injury in otologic surgery.


Sustained, locally-applied beta radiation in experimental nerve repair.


Clinical and experimental studies on the hemodynamics in acute intestinal obstruction.


The stimulus values of line drawings of human facial pictures.


The relationship between the Ammons and WAIS test performances of unselected psychiatric subjects.


The assessment of ambivalence in schizophrenic patients.


Comparison of the Bender Gestalt Test and Frostig Test in several clinical groups of children.


Emotional indicators on human figure drawings of shy and aggressive children.


Sex-change in successive draw-a-person tests.


Emotional indicators on human figure drawings and school achievement of first and second graders.


Failure to produce postural tremor by mesencephalic lesions in cats.


Bibliography on medical education. Citations obtained through the National Library of Medicine's MEDLARS program.


The treatment of polycythemia vera.

The treatment of polycythemia vera.


Sickle cell anemia.

Sickle cell anemia.


The use of platelet transfusions.

The use of platelet transfusions.


Current concepts in the therapy of multiple myeloma.


The treatment of hemochromatosis by phlebotomy.


The treatment of Hodgkin's disease.

The treatment of Hodgkin's disease.


A note on Biermer's anemia.

A note on Biermer's anemia.


Compatibility tests: an appraisal.

Compatibility tests: an appraisal.


The complications of therapy with epsilon-aminocaproic acid.


Using a clinical laboratory in the diagnosis of anemia.


Anemias of infection.

Anemias of infection.


Immunohemagglutination test for rapid detection and assay of rubella antibodies.


Antibody formation at various times after previous treatment of mice with endotoxin.


Production of generalized Shwartzman reaction in rabbits with nitrogen mustard-induced granulocytopenia.


Toxicity of L-asparaginase to resistant and susceptible lymphoma cells in vitro.


Aetiology and treatment of the corneal homograft reaction including azathioprine (Imuran).


Release of somatic antigen into filtrates of an Escherichia coli broth culture. A preliminary report.


Production of purple pigment by a mutant of Serratia marcescens.


Present-day problems of the pneumoconioses.


Delayed hypersensitivity and its significance in medicine.


Biochemical changes during sleep.

Biochemical changes during sleep.


Antithrombin 3 and diseases.

Antithrombin 3 and diseases.


Sir Benjamin Rycroft.

Sir Benjamin Rycroft.


A theoretical approach to the study of genetic parameters of histocompatibility in man.


Alkaline phosphatase.

Alkaline phosphatase.


The major medical complications of heroin addiction.


The medical sequelae of narcotic addiction.


The sectioning planes for study of temporal bones.


Philip Edward Meltzer, M.D. 1895-1967.

Philip Edward Meltzer, M.D. 1895-1967.


Separation of the organ of Corti into its component cells.


American dermatology journals. Their growth from 1870 to 1920.


The pain of acute gout. A review.

The pain of acute gout. A review.


Mode of spread in patients with localized malignant lymphoma.


Necrotizing fasciitis due to group A beta-hemolytic streptococci.


Symptomatic benign renal mesenchymoma. A case necessitating bilateral nephrectomy.


Production of granulocytic progeny by transplanted bone marrow in irradiated mice.


Sir Eardley Holland.

Sir Eardley Holland.


Mechanical stresses on lumbar disks.

Mechanical stresses on lumbar disks.


Louis Bauer, a pioneer in American orthopaedic surgery.


Cerebral palsy: symptoms and signs of diagnostic and prognostic signficance.


William Ludwig Detmold, the first American orthopaedic surgeon.


Equinus deformity in cerebral palsy.

Equinus deformity in cerebral palsy.


Management of hip deformities in cerebral palsy.


Effect of vagotomy and vagal stimulation on insulin secretion.


Clinical and experimental aspects of barbiturate withdrawal convulsions.


Ultrastructural features of canine hepatic auxiliary transplant rejection.


An over-all view of low temperature food preservation.


Drug metabolism in marine vertebrates.

Drug metabolism in marine vertebrates.


Barrier systems in insect ganglia and their implications for toxicology.


Renal transport mechanisms.

Renal transport mechanisms.


Extrapolation of pharmacologic data: lower animals to man.


Mechanisms of detoxification and transformation. Introductory remarks.


Comparative toxicity of rodenticides.

Comparative toxicity of rodenticides.


Small intestinal motility.

Small intestinal motility.


Comparative aspects of the pharmacology of smooth muscle.


Neurotransmitters and modulators in the animal kingdom.


Brief-contact therapy and drugs in outpatient treatment.


Comparative therapeutics in large domestic animals.


Veterinary therapeutics with emphasis on anthelmintics.


Acquisition of fluoride in vivo by deciduous enamel from daily topical fluoride applications.


A clinical trial of the effect of tablets stimulating salivary flow on the oral hygiene of patients wearing orthodontic appliances.


Substances of potential biomedical importance from marine organisms.


Physiological peculiarities of the ruminant relevant to drug distribution.


Role of the formylmethionine codon AUG in phasing translation of synthetic messenger RNA.


Comparative pharmacology of cardiac glycosides.


Comparative pharmacology in relation to teratogenesis.


Vitamin A deficiency: a review. I.

Vitamin A deficiency: a review. I.


The use of lyophilized parasites in indirect fluorescent antibody technique for detection of toxoplasma antibody.


Alteration of a host character by infection with RNA phage Q-beta.


The unusual animal, or to expect the unexpected.


"The luminous autumn"--the Journal and Joseph Garland.


Drugs used in the zoo.

Drugs used in the zoo.


Michael Herbert Watt.

Michael Herbert Watt.


Charles Maurice Bevan-Brown.

Charles Maurice Bevan-Brown.


Eric Robin Harty.

Eric Robin Harty.


Colin Kemp Swallow.

Colin Kemp Swallow.


Melioidosis.

Melioidosis.


Pulp response to an airstream directed into human cavity preparations.


Photosynthesis by isolated chloroplasts.


Nature and mode of action of antilymphocytic antiserum.


Reversible dissociation of tryptophanase into protein subunits.


Studies on the active center of alkaline phosphatase of E. coli.


Template functions in the enzymic formation of polyribonucleotides. 3. Apurinic acid as template.


The preferential interactions of polylysine and polyarginine with specific base sequences in DNA.


Genes and cellular differentiation.

Genes and cellular differentiation.


Recent advances in bovine obstetrics.

Recent advances in bovine obstetrics.


Anaerobic stimulated mixed culture system. A compartmented, autoclavable culture vessel has been developed for the purpose of studying interactive associations of microorganisms which are essential to the anaerobic decomposition of sewage sludge. The unit employs sterile filter membranes to subdivide the interior culture space into individual compartments. Bacteria cultured in one compartment are denied access to adjacent compartments, even though rapid interchange of nutrients and metabolic waste products occurs throughout the unit. The obligate methane-forming anaerobe, Methanobacillus omelianskii has been successfully grown and concentrated in this system by use of a synthetic medium reduced with sodium sulfide. The feasibility of using this system to study microbial interactions was, in part, demonstrated by growing M. omelianskii in a thoroughly aerated medium which had been biologically reduced by Escherichia coli prior to inoculation with the anaerobe. Under this condition of simulated mixed culture growth, the cell yield of both microorganisms, as well as specific metabolic activities ascribed to each organism, was readily monitored.


Comparison of methods for the isolation of Salmonella from bone meal. The efficiency of some methods for the isolation of Salmonella from bone meal was studied. Grinding of the granulated, industrial product was found to increase Salmonella recovery. An improvement in the efficiency of the pre-enrichment method was obtained by adding deoxycholate (1%) to mannitol broth. Selective enrichment in selenite cystine medium gave better results than in Kauffmann-Müller medium, when small inocula were used. Experimental data showed that, in the presence of large numbers of coliforms and very small numbers of Salmonella, the Kauffman-Müller medium offers better results, but, in the presence of smaller numbers of coliforms, selenite cystine is preferable. As solid selective medium, Brilliant Green Agar gave, in our laboratory, better results than S S medium.


Separan NP10, a viscosity-producing substance in culture media.


Variables affecting the foam separation of Escherichia coli. The removal of washed and standardized Escherichia coli from distilled-water suspension by foam separation with nitrogen gas and 30 mug/ml of ethylhexadecyldimethylammonium bromide surfactant was increased by increasing the gas rate from 4.3 to 9.3 liters per min and by lowering the port level at which foam was removed from 60.4 to 20.4 cm, but with concomitant increases in foam volumes. The concentrations of cells and of surfactant in the residual suspensions were related to foam volumes; a given number of cells adsorbed a constant amount of surfactant. The addition of from 10 to 500 mug/ml of inorganic salts decreased the total cell removal, with magnesium sulfate producing an anomalously large effect. The addition of surfactant in several doses (compared with a single dose) together with an increase in foaming time from 10 to 24 min produced residual suspensions with lower cell concentrations, and, when salts were present in the initial suspensions, produced lower foam volumes and more concentrated foams.


Presence of Clostridium botulinum in the Gult of Venezuela and the Gulf of Darién.


Analysis of proteolytic digests of genetic variants of alpha-s1-Casein.


The occurrence of a protein inhibitor for 5'-nucleotidase in extracts of Escherichia coli.


Isolation of a specific acyl-chymotrypsin intermediate.


Cell-free protein synthesis dependent on transfer RNA.


Sedimentation properties of E. coli RNA polymerase and its complexes with polyuridylic acid.


Studies of complexes of RNA polymerase and lambda DNA.


The relationship of adenosine and inosine transport in Escherichia coli.


Effect of glucose and other carbon compounds on the transport of alpha-methylglucoside in Escherichia coli K12.


The demonstration of the elementary particles of mitochondrial membranes fixed with glutaraldehyde.


Immunofluorescent localization of Tamm-Horsfall mucoprotein.


Genetic studies of paralyzed mutant in Salmonella. I. Genetic fine structure of the mot loci in Salmonella typhimurium.


A review of skin preservation.

A review of skin preservation.


Studies of heat-inducible lambda-phage. 3. Mutations in cistron N affecting heat induction.


Structure and properties of skin and of its components from the point of view of preservation by freezing and freeze-drying.


Polyribosome metabolism in Escherichia coli. I. Extraction of polyribosomes and ribosomal subunits from fragile, growing Escherichia coli.


Cryopreservation of skin: discussion and comments.


Modification of leucyl-sRNA after bacteriophage infection.


Some effects of bromouracil on the kinetics of thymineless death in Escherichia coli.


Regulation of chromosome replication in Escherichia coli: a comparison of the effects of phenethyl alcohol treatment with those of amino acid starvation.


Bronchial dynamics and the reconstitution of bronchial artery supply in the autotransplanted lung.


Volume changes in bone marrow and Ehrlich ascites cells after freezing as an index of preservation efficiency.


Molecular recombination following conjugation in Escherichia coli.


Percutaneous noncatheter arteriography and aortography. II. Brachial aortography and peripheral arteriography.


Postlymphangiogram film as an indicator of tumor activity in lymphoma.


Physical and chemical characterization of two- and three-stranded adenine-thymine and adenine-uracil homopolymer complexes.


Amino acid sequence of the f2 coat protein.


Statistical dependency between interspike intervals of spontaneous activity in thalamic lemniscal neurons.


Robert P. Grant (1915 to 1966)--in memoriam.


Inhibition of protein synthesis by polypeptide antibiotics. 3. Ribosomal site of inhibition.


A freeze-tolerant solid medium for detection and sampling of air-borne microorganisms at subzero temperature.


Initiation by the DNA-dependent RNA polymerase.


A genetic locus responsible for generalized high mutability in Escherichia coli.


Spore germination in Dictyostelium discoideum.


Self-selection of alcohol by animals, human variation, and the etiology of alcoholism. A critical review.


Dr. W.R. Wooldridge.

Dr. W.R. Wooldridge.


The treatment of thyrotoxicosis with radioactive iodine.


Dr. W. R. Wooldridge.

Dr. W. R. Wooldridge.


An experimental study of the fate of autografts of whole-thickness skin used to replace the anterior cruciate ligament.


A survey of Hand-Schüller-Christian's disease in otolaryngology.


Alcohol and college youth.

Alcohol and college youth.


Bioflavonoid therapy in senxori-neural hearing loss. A double-blind study.


Teenagers and alcohol: recent research.

Teenagers and alcohol: recent research.


Electron microscopy in the study of muscular dystrophy.


Staphyloma of the sclera repaired by corneal graft.


Surgical approach to carotid arterial insufficiency. Risks and results.


Modified Blalock-Hanlon procedure for transposition of the great vessels.


Comparative electron microscopic studies on various forms of muscle atrophies and dystrophies in animals and man.


Regional temporal bone banks centers and areas served.


Survival of bacteria on metal surfaces.

Survival of bacteria on metal surfaces. Survivor curves were determined for Serratia marcescens, Sarcina lutea, Pasteurella tularensis, and P. pestis deposited from the airborne state onto metallic surfaces and subsequently stored at various humidities and temperatures. Cells of all species tested remained alive longest in a dry atmosphere, except that cells of S. marcescens survived best in a saturated atmosphere. Survival decreased most rapidly at the intermediate humidity level for three of the test organisms, yet P. tularensis died most rapidly in a saturated atmosphere. An increase in temperature decreased survival of P. pestis and P. tularensis.


Hemagglutination-inhibition method and immunofluorescence staining with Venezuelan equine encephalomyelitis virus. Hemagglutination and fluorescent antibody (FA) are compared for the direct detection of virus devoid of host cells. A determination was made of the minimal number of tissue plaque-forming units of Venezuelan equine encephalomyelitis virus that could be detected by the hemagglutination technique. Similar concentrations of the virus in bovine albumin borate saline, Brain Heart Infusion broth (Difco), and demineralized water were tested by the FA technique. Somewhat higher concentrations of the virus in bovine albumin borate saline were used in the hemagglutination-inhibition test. The quantitative hemagglutination procedure employed for these studies was carried out at 37 C for 75 min with variations in concentration of goose red cells. As a result of lowering the red cell concentration, smaller concentrations of virus were detected. The direct FA staining procedure applied to slide preparations containing known numbers of tissue culture plaque-forming units of virus was negative. Adsorbed viral antigen on agglutinated goose erythrocytes was visualized by direct and indirect FA techniques.


Identification of fluorescent-antibody labeled group A streptococci by fluorometry. A quantitative system, amenable to automation, for determining the presence of group A streptococci in broth culture is described. After separation from the broth, the cells' protein coats are removed by digestion with 0.1% trypsin, and they are then stained with anti-A fluorescent antibody (FA). Excess FA is removed, and bound FA is put into solution by dissociation with demineralized distilled water. The amount of FA bound to the cells is quantitated by fluorometry of the solution. The level of nonspecific staining is measured by staining the cells with fluorescein-conjugated normal rabbit globulin absorbed with group A cells, dissociating, and quantifying, as above. The two quantities are subtracted to measure specific binding of FA to group A cells. A clinical trial showed 92% agreement with microscopists.


Effect of available water on thermal resistance of three nonsporeforming species of bacteria. Cells of Escherichia coli, Pseudomonas fluorescens, and Staphylococcus aureus, previously grown in Trypticase Soy Broth (TSB) at a high level of available moisture (a(w) 0.994) and at low levels produced by addition of NaCl or glucose, were heated in neutral phosphate buffer, and in this buffer adjusted to low levels of available moisture by means of NaCl or glucose. Glucose in the heating medium was more protective than NaCl for E. coli and P. fluorescens, but hastened the thermal destruction of S. aureus. Added protection was given P. fluorescens during heating in glucose-buffer solution at a(w) 0.97 by previous growth in TSB adjusted to that a(w) value with glucose. Added protection was given E. coli during heating in NaCl-buffer solution at a(w) 0.98 by previous growth in TSB adjusted to that value with NaCl. With S. aureus, however, previous growth in TSB plus NaCl or glucose had little effect on heat resistance, but the solute in the heating medium had great influence, in that NaCl was very protective and glucose destructive. Opportunity may have been given during tempering of the cell suspension at 30 C in the heating medium prior to heating for the NaCl and glucose to diffuse into the staphylococcal cells.


Application of an end point dilution method to bacteriophage assay.


Rapid serial dilution technique with self-filling syringes.


Alfred Newton Richards.

Alfred Newton Richards.


D- and L-lactate dehydrogenases in Escherichia coli.


An improved preparation of L-rhamnulose 1-phosphate.


Otolithic influences on the unitary discharge of the oculomotor nucleus.


Submicroscopic histochemical demonstration of intracellular reactive zinc in beta cells of pancreatic islets.


Unnecessary use of tranquilizers in elderly patients.


A review of aperture and ceiling-shine effects in fallout shielding technology.


Hematopoietic tissue neoplasms in animals administered 90Sr.


Radiophotoluminescence dosimetry--a bibliography.


Inhibition by mikamycins of polypeptide synthesis directed by native messengers and synthetic polynucleotides.


Studies on soluble cytochromes in Enterobacteriaceae. II. Cytochromes b-562 and c-550.


Beta-galactosidase formation controlled by an episomal gene during the cell cycle of Escherichia coli.


A melting point for the birefringent component of muscle. The A filament of the striated muscle sarcomere is an ordered aggregate of one or a few species of proteins. Ordering of these filaments into a parallel array is the basis of birefringence in the A region, and loss of birefringence is therefore a measure of decreased order. Heating caused a large decrease in the birefringence of glycerinated rabbit psoas muscle fibers over a narrow temperature range ( approximately 3 degrees C) and a large decrease in both the birefringence and optical density of the A region of Drosophila melanogaster fibrils. These changes were interpreted as a loss of A filament structure and were used to define a transition temperature (T(tr)) as a measure of the stability of the A region. Since the transition temperature was sensitive to pH, ionic strength, and urea, solvent conditions which often affect protein structure, it is an experimentally useful indicator for factors affecting the structure of the A filament. Fibers from glycerinated frog muscle were less stable over a wide pH range than fibers from glycerinated rabbit muscle, a fact which demonstrates a species difference in structure. Glycerinated rabbit fibrils heated to 70 degrees C shortened to about 40% of their initial length. The extent of shortening was not correlated with the loss of birefringence, and phase-contrast microscopy showed that this shortening occurred in the I region as well as in the A region. This response may be useful for studying the I filament and actin in much the same way that the decrease in birefringence was used for studying the A filament and myosin. The observations presented show that some properties of muscle proteins can be studied essentially in situ without the necessity of first dispersing the structure in solutions of high or low ionic strength.


To the memory of Professor Alexander L. Myasnikov (1899-1965).


Fine structure of Sciara coprophila sperm. Though the fagellum of Sciara sperm arises from a blepharoplast and is characterized by doublet tubules with arms, it differs markedly from the familiar type of flagella in the number and arrangement of its tubules. The axial filament complex in sperm from the testis of Sciara consists of approximately 70 doublet tubules, each with an associated singlet tubule. Near the nucleus these tubules are displaced in an oval array. Posteriorly the oval breaks and coils from one free end so that the axial filament complex at posterior levels has the form of a spiral. The singlet tubules do not extend the full length of the sperm but terminate in order from inside the spiral. Farther posteriorly the axial filament complex reverses the direction of coiling, and the doublets terminate from outside the spiral. Four arms are specifically positioned on the singlet and doublet tubules. A single mitochondrial derivative extends most of the length of the sperm; it consists of a large mass of proteinacious material, a crystalloid located adjacent to the axial filament complex, and peripheral cristae. In the female genital tract, sperm undergo gross morphological changes which include sloughing of practically all the mitochondrial material except the crystalloid, repositioning of the crystalloid, and uncoiling and subsequent recoiling of the axial filament complex into a different configuration. From analysis of serial sections it was determined that the orientation of arms, when the axial filament is viewed from base to tip, is the same as in conventional flagella.


Role of lipids in the structure and function of biological membranes. The concept of biological membranes as vesicular or tubular continua built up of nesting repeating units has been systematically explored and some of the relevant experimental work has been assembled. The bulk of the data have been drawn from studies on the mitochondrion, which is assumed to be a model for membranes generally. The repeating units of membranes are composite macromolecules containing both protein and lipid. The unit of the mitochondrial inner membrane is tripartite; the basepiece is the membrane-forming element. The four complexes of the electron transfer chain represent the different species of basepieces in the inner membrane. The repeating units of the outer mitochondrial membrane have a different form and size and a completely different set of enzymes (the enzymes of the citric and fatty acid oxidation cycles). The repeating units of the inner mitochondrial membrane are capable of forming membranes spontaneously. This membrane-forming capability is absolutely dependent on the presence of lipid. Evidence is presented for the view that lipid restricts the number of binding modalities and thus compels a two-dimensional alignment of repeating units. In absence of lipid three-dimensional stacking takes place, and the aggregates thus formed are, in effect, bulk phases. The membrane may be looked upon as a device for molecularizing repeating units, and it is this molecularization which underlies the essentiality of lipid for electron transfer. The theory of lipid requirement for enzymic activity is developed. The reconstitution of the electron transfer chain is shown to be essentially a membrane phenomenon rather than an expression of direct chemical interaction between the different parts of the electron transfer chain.


Sex-linked censure expectancies in process and reactive schizophrenics.


In vitro studies on Patiria mininata (Brandt) coelomocytes, with remarks on revolving cysts.


Immunofluorescence as an aid to the diagnosis of Corynebacterium pyogenes infection.


A bibliography on autoradiographic studies of mammalian chromosomes.


Successful tissue transplantation in frogs produced by nuclear transfer.


Hyperpyrexia during anaesthesia.

Hyperpyrexia during anaesthesia.


Hyperpyrexia in association with general anaesthesia in children.


Ultrastructural localization of alkaline phosphatase activity in the absorbing cells of the duodenum of mouse.


Factors in the suspending media which alter the carbon clearance rate.


Effect of sodium-copper-chlorophyllin as a complement inhibitor on the allograft reaction.


Histochemical demonstration of beta-glucuronidase and N-Acetyl-beta-glucosaminidase on paraffin section using naphthol AS substrates.


Viability studies with Mycoplasma gallisepticum under different environmental conditions.


Distribution of Mycoplasma gallisepticum in selected tissues and organs of artificially infected turkeys.


Studies on the mechanism of split tolerance in mice.


Further observations on potential immunologically competent cells of fetal liver origin.


Allograft tolerance in thymectomized mice injected with small doses of spleen cells.


The cumulative effect of histocompatibility antigens.


Supply and demand in kidney and liver transplantation: a statistical survey.


Effect of antilymphocytic serum on the survival of renal homotransplants in dogs.


Induction of tolerance to homografts in rats in the offspring of parabiotic mothers.


Comparison of the histocompatibility requirements of skin and tooth germ grafts.


The use of tetracycline fluorescence in the evaluation of ischaemic changes in renal transplantations.


An index to deoxyribonucleic acid base compositions of bacterial species.


Comparison of freeze-dried daughter strains of BCG by aerogenic immunization and virulent challenge.


A new service for sensitivity tests.

A new service for sensitivity tests.


A clinical trial of thiocarlide (4-4' diisoamyloxythiocarbanilide).


Tablets of coated aspirin microspherules--a new dosage form.


IBM-Fortran computer calculations for analytical ultracentrifuge data.


The antidepressant properties of IN 1060: a preliminary report.


Ribonucleic acids fractionation by density-gradient centrifugation and by agar gel electrophoresis: a comparison.


Alterations in pulmonary surfactant following compression atelectasis, pulmonary artery ligation, and reimplantation of the lung.


Salvage of severed or near-severed arms.


Value of renal blood flow measurement with xenon-133 at the time of kidney transplantation.


Military psychiatry. A prototype of social and preventive psychiatry in the United States.


Evaluation of psychotropic drug therapy in chronic hyperventilation syndrome: intensive study design.


The inhibition of polynucleotide phosphorylase by certain substrate analogues.


Reutilization of degradation products of ribosomal ribonucleic acid in Escherichia coli strain B during the phosphorus-deficient stage.


Peptidyl-transfer RNA: an intermediate in protein biosynthesis.


Peptide chain initiation and growth in the induced synthesis of beta-galactosidase.


Inhibition of protein, RNA and DNA synthesis in Escherichia coli by p-methoxyphenethyl alcohol.


A chemical method for the purification of amino acid-specific transfer RNA's.


Interaction of streptonigrin with DNA in vitro.


Temperature-sensitive synthesis of isocitrate lyase in Escherichia coli.


Scanning methods: volume quantitation of tissues, cells and subcellular components.


Infected ventriculoatrial shunts. A method of treatment.


Placental transfusion: early versus late clamping of the umbilical cord.


Rapid decalcification followed by a new fuchsin-methylene blue stain for acid-fast bacilli in frozen sections.


Genetic control of prophage insertion specificity in bacteriophages lambda and 21.


Use of dilute osmium tetroxide for preservation of three-dimensional crystals of tobacco mosaic virus.


The urinary sediment after renal transplantation. Quantitative changes as an index of the activity of the renal allograft reaction.


Treatment of trigeminal neuralgia with tegretol.


Therapeutic results in 133 cases of spina bifida.


Bone conduction measurement: mastoid versus upper central incisor.


General surgical complications associated with renal allotransplantation using related donors.


Of man's heart valves and strep's cell walls.


Heterotopic auxiliary liver transplantation. I. A physiological concept of functional competition.


Heterotopic auxiliary liver transplantation. II. A technique for heterotopic partial liver homotransplantation in dogs.


Late degenerative changes in the cornea following breaks in Descemet's membrane.


Heterotopic auxiliary liver transplantation. 3. Functional competition--cause of atrophy of the auxiliary liver transplant.


Neutrophilic function in animals with the Chediak-Higashi syndrome.


A comparison of the effects of varying dose levels of oxypertine on mood and physical performance of trained athletes.


Dr. Camille Dreyfus.

Dr. Camille Dreyfus.


The lined forehead flap in reconstructive procedures of the face.


Bilateral distal tibial and fibular epiphyseal separation associated with spina bifida. A case report.


Aortic arch syndrome (brachiocephalic ischemia).


Bacteriocins and phages produced by Serratia marcescens.


Oren C. Durham (1889-1967).

Oren C. Durham (1889-1967).


Treatment of spinal tuberculosis in Korea, using focal débridement and interbody fusion.