Unusual complications of acute bronchial asthma.


Technique of tracheotomy.

Technique of tracheotomy.


Transfusion of "fresh blood".

Transfusion of "fresh blood".


Fine structural study of the microgametogenesis of Eimeria auburnensis.


[Study of bleomycin on brain tumors. 1. Inhibitory effect of bleomycin on cultured brain tumor cells].


Determination of terodiline (Bicor) in serum by gas chromatography and electron capture detection of benzophenone formed by chromic acid oxidation.


Studies on a proposed fluxional system in the tocopherol spiro dimer.


The directing effect of annulated rings in aromatic systems. 3. Bromation of chromanols related to tocopherols.


Studies on the medicinal chemistry of oxoquinazolines. VI. Mass spectra of isomeric N- and O-alkylated 4-oxoquinazolines.


Biological assay of cholecystokinin in guinea-pig gall-bladder in situ.


Synthesis of 1,4-bis(2-oxopyrrolidino)-2-butyne, a metabolite of tremorine.


Some pharmacological properties of cholecystokinin.


The production of infusion fluids of low particle content.


Potential local anaesthetics. II. Basic N-(alpha, alpha-dimethylbenzyl)- and N-(alpha, alpha, p-trimethylbenzyl)acylamines.


Observation on some possible attractants of tsetse flies (Glossina morsitans Westw. and G. pallidipes Aust.).


Some interesting points about the practice of ophthalmology in Democratic Germany.


Comparative study of monthly courses versus weekly doses of 5-fluorouracil (NSC-19893).


Treatment of cervical carcinoma by methotrexate (NSC-740) with cyclophosphamide (NSC-26271).


Hyperammonemia in cor pulmonale.

Hyperammonemia in cor pulmonale.


Complete heart block with total recovery in a previously healthy 17-year-old boy.


Diagnosis of uraemia post mortem.

Diagnosis of uraemia post mortem.


Neurogenic dysfunction of the urinary bladder. An experimental and clinical study with special reference to the ability of electrical stimulation to establish voluntary micturition.


An internal standard for amino acid analyses: S-beta-(4-pyridylethyl)-L-cysteine.


An improved Calliphora bioassay for insect moulting hormones.


Cat collars impregnated with dichlorvos ineffective against ear mites.


Effects of the protein content of the diet on the development of nephrocalcinosis in rats.


Accurate estimation of pentose in purine and pyrimidine nucleotides in quantities from 1 microgram.


Determination of iron in heme compounds. 3. Extension and modification of the method.


Electromyographic study of the pectoralis major and latissimus dorsi muscles during medial rotation of the arm.


Preparation and characterization of sulfoxides of S-adenosyl-L-homocysteine and S-ribosyl-L-homocysteine.


Electromyographic investigation of muscle imbalance in patients with paralytic scoliosis.


Ophthalmodynamometry and ophthalmodynamography in subclavian steal syndrome.


Cholinesterase activity in normal and cataractous human lens.


Cultural characteristics of the brown rot fungi (Sclerotinia spp.).


New homothallic neurosporas from tropical soils.


Isolation of Trichophyton vanbreuseghemii from soil in Alberta, Canada.


Non-linear transport behaviour in very thin membranes.


The influence of major surgery on kinin-forming, kinin-destroying and alkaline phosphatase activities in urine.


Disseminated intravascular coagulation in shock.


The role of the platelet and leukocyte in disseminated intravascular coagulation caused by bacterial endotoxin.


Teratology of the beetle Tenebrio molitor. V. Ultrastructural changes and viruslike particles in the foregut epithelium of pupal-winged adults.


Insecticidal activity of thirty-one strains of Bacillus against five insect species.


The inflammatory response of the cockroach Leucophaea maderae to injections of normal and abnormal tissues.


Nuclear polyhedrosis of Heliothis: stability and relative infectivity of virions.


Biochemical studies on the multiplication of a nuclear-polyhedrosis virus in the silkworm, Bombyx mori. I. Nucleic-acid synthesis in larval tissues after infection.


Electron-microscopic studies on hemocytes of the Egyptian cottonworm, Spodoptera littoralis (boisduval) infected with a nuclear-polyhedrosis virus, as compared to noninfected hemocytes. I. Noninfected hemocytes.


An electron-microscope study of the constituents of encapsulating cysts in the American oyster, Crassostrea virginica, formed in response to Tylocephalum metacestodes.


Nuclear-polyhedrosis and cytoplasmic-polyhedrosis virus infections in Louisiana mosquitoes.


Annulment of amphotericin B inhibition of Coccidioides immitis endospores. Effects on growth, respiration and morphogenesis.


Attributes of deficient immunity in mice receiving Coccidioides immitis Spherule vaccine by the intravenous route.


Mating behaviour of Trichophyton mentagrophytes varieties paired with Arthroderma benhamiae mating types.


Protein synthesis by phagocytized yeast cells of Histoplasma capsulatum.


Some observations on Arthroderma uncinatum.


Effect of hydrogen ion concentration and of temperature on the growth of Paracoccidioides brasiliensis in soil extracts.


Factors affecting serum inhibited growth of Candida albicans and Cryptococcus neoformans.


[Is blood gas analysis to be considered as a routine investigation?].


The pigmentation of bovine serum albumin by the "black yeast" Phialophora jeanselmei.


The usefulness of praxiological notions for evaluation of the efficiency of health care activities.


The indices of the function of a 1,000 bed general hospital in Hungary.


Critical path analysis in planning of the course of surgical procedures.


Modern conception of hospital organization.


Control of leprosy.

Control of leprosy.


Rural leprosy control problems in Biafra and central India: a comparison.


Leprosy control work at Polambakkam and its critical appraisal.


Results after five years of intensive leprosy control work in a highly endemic area.


Leprosy control in Tanzania.

Leprosy control in Tanzania.


Leprosy control in the southern province of Zambia.


A spectrographic investigation of some diphthongal phonemes in Australian English.


Leprosy control in the Teso District, Uganda--a review of the last twenty years.


LEPRA control project in Malawi.

LEPRA control project in Malawi.


Some experiments with queer sentences.

Some experiments with queer sentences.


A plan of leprosy control in Nepal being carried out in a general hospital.


Psycholinguistic study of a schizophrene's speech.


Integration of leprosy control into the health centre scheme.


Student views of the new pre-clinical. A questionnaire course.


The department of general practice.

The department of general practice.


Sexual disharmony in marriage.

Sexual disharmony in marriage.


Physiologist in India.

Physiologist in India.


Fatigue, the subtle killer.

Fatigue, the subtle killer.


The routine treatment of offenders in the National Health Service.


The evaluation of post-mortem blood sugar levels and their correlation with the glycogen content of the liver.


A study of syllabic stress in some English words as produced by deaf and normally hearing speakers.


Fatigue and automobile driving.

Fatigue and automobile driving.


The role of radiology in forensic pathology.


Medical evidence in adoption and custody cases.


The use and abuse of documents. (An introduction to questioned document examination).


Some fallacies about the photography of luminescence.


The Abortion Act 1967: the legal aspects.


The Abortion Act--a gynaecologist's view.


Family law.

Family law.


The scope of blood grouping in the elucidation of problems of paternity.


Blood tests in the establishment of paternity.


Homosexuality and abortion. A psychiatrist's observations.


Alcohol and driving.

Alcohol and driving.


Recent changes in legislation. A police officer's observations.


The influence of medical and biological progress on the criminal law.


Reforms in blood test law.

Reforms in blood test law.


Subnormality and crime. II.

Subnormality and crime. II.


The use of body temperature in estimating the time of death and its limitations.


Psychiatric aspects of mental health legislation.


Controversial crusaders.

Controversial crusaders.


Collaboration between doctors and jurists as the basis of a new penal justice.


Liver changes resembling those seen in acute phosphorus poisoning in a patient receiving cytotoxic drugs.


Inaccuracy and under-reporting in certification of death following urethral stricture.


Furnishing the waiting area.

Furnishing the waiting area.


Intercommunication systems for the surgery.


Are your home, surgery and family litigation-proof?


The Giro's first six months.

The Giro's first six months.


Safeguarding the health of employees: an important new principle.


Planning retirement to the country.

Planning retirement to the country.


An adaptable surgery and its systems.

An adaptable surgery and its systems.


Rapid measurements of red blood cell fragility.


Alcohol flaming--a possible source of contamination in sterility testing.


Diagnosis of Haemophilus vaginalis by Papanicolaou smears.


A modified "last stop pin" for technicon's sampler II.


Interference with certain chemical analyses caused by dextran.


Efficiency and validity of abbreviated ECG lead system composed of leads aVf, V1 and V5 as a screening test.


Species differences of the effects of x-irradiation upon the rat and mouse embryo.


Effect of monochromatic light environment on color discrimination learning in pigeons.


Plasma free fatty-acid response and adrenal medullary and cortical secretion following glucagon injections.


Frequency changes of alpha brain waves during 3 days of sensory deprivation.


Are cortical DC potentials neuronal or metabolical?


The onset of anaemia and the production of haemoglobin C in sheep fed on kale.


Mid-piece sperm abnormality due to high temperature exposure of rams.


Injuries to the elbow.

Injuries to the elbow.


Inguinal herniorrhaphy reduced to basic principles.


Management of hilar injury of the liver.


The menopause and prognosis in breast cancer.


Artificial ski-slope injuries.

Artificial ski-slope injuries.


Pitfalls in the diagnosis of coronary disease.


Diet and coronary disease.

Diet and coronary disease.


An alternative to paste in the treatment of gravitational ulcers.


A case of Weil's disease.

A case of Weil's disease.


An illness associated with Coxsackie virus B2 in a residential school.


Blood urea estimation in general practice. 'Azostix' and 'Urastrat'.


Specialist or generalist?

Specialist or generalist?


The primary physician--generalist or specialist?


Hazards of general practice. A running commentary.


Erythropoietin levels in cord blood of control infants and infants with respiratory distress syndrome.


Paediatric education. The place of "social paediatrics" in undergraduate teaching.


Acid-base and electrolyte balance in newborn infants of diabetic mothers.


The diagnosis of iron deficiency anemia in children.


Gastroenteritis with secondary disaccharide intolerance. An outbreak in a premature unit.


Familial aplastic anaemia without congenital malformations.


The noise level in a childrens hospital and the wake-up threshold in infants.


Removal of indirect reacting bilirubin by albumin binding during intermittent peritoneal dialysis in the newborn.


Secondary cystathioninuria.

Secondary cystathioninuria.


The effect of cobamide coenzyme in methylmalonic acidemia.


An inherited B-C translocation in a dysplastic girl with partial C trisomy.


Neonatal nonspherocytic hemolytic anemia due to glucose-6-phosphate dehydrogenase deficiency in a Danish infant.


Remarks on two species of the genus Cotylurus Szidat: C. platycephalus (Creplin, 1825) and C. cucullus (Thoss, 1897) = C. communis (Hughes, 1928)).


Neoplastic equivalents of protozoa.

Neoplastic equivalents of protozoa.


Mechanism of catalase induction in Rhodopseudomonas spheroides: role of porphyrin excretion.


Mechanism of catalase induction in Rhodopseudomonas spheroides: the effects of acridine, acriflavin, and diphenylamine.


Isolation problems and structural organization of membrane units in Mycobacterium sp. smegmatis.


Comparative aspects of cold acclimation and nonshivering thermogenesis in homeotherms.


Dynamics of adaptive reactions at the cellular level during training of rats of hypoxia. Review of research.


Observations on dosage of drugs for anesthesia of domestic animals in temperature and tropical climate.


Thermoregulation in the domestic fowl exposed to a natural climate.


The effect of the natural climate of the Sahara and controlled climate on the rectal temperature and cardiorespiratory activities of Friesian cattle and water buffaloes.


The effect of the natural climate of the Sahara and controlled climate on thyroid gland activity in Friesian cattle and water buffaloes.


The short--term variation of asthma in Brisbane: its relation to the weather and other factors.


Effect of altitude upon 1968 Olympic Games running performances.


Sound and pattern in "artificial" fluency.


Stimuli and intensity factors in testing infants.


Assessing communication attitudes among stutterers.


Perception of the aging male voice.

Perception of the aging male voice.


Comparison of techniques for discriminating among talkers.


Individual specificity of the late components of averaged electroencephalic responses (AERS) evoked by repeated clicks.


Social class differences in children's syntactic performance: a quantitative analysis of field study data.


A psycholinguistic approach to study of the language deficit in aphasia.


Loudness discomfort level modification.

Loudness discomfort level modification.


The influence of prosody on stuttering adaptation.


Spontaneous recovery from aphasia.

Spontaneous recovery from aphasia.


Anticipation and stuttering: a pupillographic study.


Practice effects in frequency discrimination by hearing impaired children.


Comparative Bekesy typing with broad and modulated narrow-band noise.


Probability learning by aphasic subjects.


Bekesy audiometry and temporal summation.


A task for evaluation of articulation change. 3. Imitative task scores compared with scores for more spontaneous tasks.


Measurement, and visualisation with cholesteric liquid crystals, of the alterations of the peripheral blood circulation after smoking.


Syndrome of cellular agony--biochemical characterization.


Computer processing of medical text information.


Adapting a general purpose information processing system to a new environment.


Daily treatment planning with an on-line shared computer system.


Decomposition of oxalic acid and other organic acids by streptomycetes as a taxonomic acid.


Photochemical oxygen evolution by Chlorella fusca in glucose.


Brain and cerebrospinal fluid free amino acids in phenylketonuria.


Characterization of rapidly labelled RNA associated with DNA in Chlorella.


Dendritic arborization of the hypothalamus in mouse.


Photodynamic action on the transplabtabiligy of 4NQO-induced tumor cells.


The effect of H-ion concentration upon aerobic polysaccharide synthesis by resting cells of Saccharomyces cerevisiae.


Inactivation of Candida albicans by ultraviolet radiation.


Aquatic fungi of iceland: Phlyctohytrium Schroeter.


A marine isolate of Pseudomonas nigrifaciens. II. Characterization of its blue pigment.


Bacterial degradation of riboflavin. VII. Studies on the bacterial decomposition of 6,7-dimethylquinoxaline-2,3-diol.


A proposal for the transfer of Streptomyces mediterranei Margalith and Beretta 1960 to the genus Nocardia as Nocardia mediterranea (Margalith and Beretta) comb. nov.


Differential effects of growth temperatures on inactivation and mutation of Candida albicans by ultraviolet radiation.


Metabolism of sinapic acid and related compounds in the rat. 1. Administration of sinapic acid to the rat results in the excretion of 3-hydroxy-5-methoxyphenylpropionic acid, dihydrosinapic acid, 3-hydroxy-5-methoxycinnamic acid and unchanged sinapic acid in the urine. The sinapic acid conjugate sinalbin is also catabolized to free sinapic acid and 3-hydroxy-5-methoxyphenylpropionic acid in the rat. 2. 3,4,5-Trimethoxycinnamic acid is metabolized in part to sinapic acid and 3-hydroxy-5-methoxyphenylpropionic acid. 3. 3,5-Dimethoxycinnamic acid is metabolized to 3-hydroxy-5-methoxycinnamic acid and 3-hydroxy-5-methoxyphenylpropionic acid. 4. The metabolic interrelationships of these compounds were studied by the administration of intermediates and a metabolic pathway is proposed. 5. The metabolism of the corresponding benzoic acids was studied, but these compounds and their metabolites were shown not to be intermediates or products of the metabolism of the related cinnamic acids.


Kinetics of thiamin cleavage by sulphite. Results are presented on the rate of thiamin cleavage by sulphite in aqueous solutions as affected by temperature (20-70 degrees ), pH(2.5-7.0), and variation of the concentration of either thiamin (1-20mum) or sulphite (10-5000mum as sulphur dioxide). Plots of the logarithm of percentage of residual thiamin against time were found to be linear and cleavage thus was first-order with respect to thiamin. At pH5 the rate was also found to be proportional to the sulphite concentration. In the pH region 2.5-7.0 at 25 degrees the rate constant was 50m(-1)hr.(-1) at pH5.5-6.0, and decreased at higher or lower pH values. The rate of reaction increased between 20 degrees and 70 degrees , indicating a heat of activation of 13.6kcal./mole.


The mechanism of biosynthesis and direction of chain extension of a poly-(N-acetylglucosamine 1-phosphate) from the walls of Staphylococcus lactis N.C.T.C. 2102. 1. The synthesis of a polymer of N-acetylglucosamine 1-phosphate, occurring in the walls of Staphylococcus lactis N.C.T.C. 2102, was examined by using cell-free enzyme preparations. The enzyme system was particulate, and probably represents fragmented cytoplasmic membrane. 2. Uridine diphosphate N-acetylglucosamine was the only substrate required for polymer synthesis and labelled substrate was used to show that N-acetylglucosamine 1-phosphate is transferred as an intact unit from substrate to polymer. 3. The properties of the enzyme system were studied. A high concentration of Mg(2+) or Mn(2+) was required for optimum activity, and the pH optimum was about 8.5. 4. End-group analysis during synthesis in vitro showed that newly formed chains contain up to about 15 repeating units. Pulse-labelling indicated that chain extension occurs by transfer from the nucleotide to the ;sugar-end' of the chain, i.e. to the end that is not attached to peptidoglycan in the wall.


The development of gluconeogenesis in rat liver: experiments in vivo. 1. The injection of substrate amounts of lactate into newborn rats produced an increase in the concentration of phosphoenolpyruvate in liver. Similar experiments with foetal rats showed no increase in phosphoenolpyruvate concentration although pyruvate formation was observed. 2. The administration of pyruvate to foetal rats was also without effect on the hepatic phosphoenolpyruvate concentration, although a 20-fold increase in this was observed when pyruvate was injected into newborn animals. 3. Analogous experiments with aspartate produced qualitatively similar differences between foetal and newborn rats. 4. When [(14)C]-lactate, -pyruvate or -aspartate was injected into foetal or newborn rats incorporation of radioactivity into liver glucose was observed only in the newborn animals. 5. Lactate/pyruvate ratios of 213 in foetal liver and 13.5 in the livers of newborn rats indicated a relatively reduced environment in the cytosol of foetal liver. This difference in redox state was illustrated experimentally by a greater conversion of pyruvate into lactate and an increased formation of malate in foetal liver. 6. Although both the substrate-loading and tracer experiments indicated a block in gluconeogenesis in foetal liver at the stage of conversion of oxaloacetate into phosphoenolpyruvate, gluconeogenesis was also hindered by a highly reduced environment.


The effect of protein content of the diet on the rate of urea formation in sheep liver. 1. In the livers of six sheep given a high-protein diet, the concentrations of certain urea-cycle enzymes [ornithine transcarbamoylase, arginine synthetase (combined activity of argininosuccinate synthetase and argininosuccinase) and arginase] were significantly greater than when the sheep were given a low-protein diet. Alkaline phosphatase activity/mg. of liver protein was not significantly affected by diet. 2. Three sheep previously given the high-protein diet showed no significant rise in the concentration of ammonia in the blood after the administration of urea (0.5g./kg. body wt.). The concentration of ammonia in the blood of the three sheep given the low-protein diet rose exponentially with time after dosing with urea and all sheep died. 3. It is suggested that tolerance to ammonia toxicity in the sheep is at least partly a function of the activity of the urea-cycle enzymes in the liver.


The amino acid composition of jack-bean urease.


The subunit structure of jack-bean urease. 1. Urease of specific activity 160-180 Sumner units/g. (Sumner, 1951) was purified from jack-bean meal. The preparation was pure on the basis of polyacryl-amide-gel electrophoresis and N-terminal studies. 2. By using both the 1-fluoro-2,4-dinitrobenzene method and the phenyl isothiocyanate method a single N-terminal methionine residue was found. 3. A single C-terminal sequence -Tyr-Leu-Phe was found by studies with carboxypeptidase A, carboxypeptidase B and hydrazinolysis. 4. N-Bromosuccinimide cleavage showed that five unique tryptophan sequences were present: Trp-Ala, Trp-Glu, Trp-Gly, Trp-Met and Trp-Arg. 5. Polyacrylamide-gel electrophoresis in sodium dodecyl sulphate showed that urease had a subunit molecular weight of 76000. 6. The yield of N- and C-terminal amino acids, the number of tryptic peptides and tryptophan sequences and the above polyacrylamide-gel electrophoretic measurement all suggest that urease contains a single structural subunit of molecular weight 75000.


Changes in certain kinetic properties of hepatic microsomal aniline hydroxylase and ethylmorphine demethylase associated with postnatal development and maturation in male rats. 1. Changes in certain kinetic properties (V(max.) and apparent K(m)) of hepatic microsomal mixed-function oxidases have been studied as a function of postnatal development and maturation in male rats. 2. Microsomal cytochrome P-450 content changed only slightly between 1 and 12 weeks of age. 3. Aniline hydroxylase activity (V(max.)) increased abruptly between 1 and 2 weeks of age to greater than adult activities and then returned to a plateau value between 4(1/2) and 12 weeks of age. Ethylmorphine demethylase activity remained low and relatively constant between 1 and 3 weeks of age and then increased markedly ( approximately 100%) between 3 and 4(1/2) weeks. 4. The apparent Michaelis constant (K(m)) for aniline hydroxylation increased almost linearly with time between 1 and 6 weeks of age and tended to reach a plateau value thereafter. The apparent K(m) for ethylmorphine demethylation increased between 1 and 3 weeks of age and then decreased abruptly to a constant value between 6 and 12 weeks. 5. The data indicate that developmental changes in the activity of these microsomal oxidases do not correlate temporally with each other or with changes in microsomal cytochrome P-450 content. 6. The most dramatic changes in enzyme activity were associated with early development (1-3 weeks) and weaning (3-4 weeks). 7. Changes in weight of seminal vesicle, a criterion of sexual maturation in male rats, were most prominent between 6 and 8 weeks of age and thus appeared to be separated in time from the prominent changes in enzyme activity.


The action of a bacterial agarase on agarose, porphyran and alkali-treated porphyran. 1. A purified extracellular agarase from a Cytophaga species was used to hydrolyse agarose, porphyran and alkali-treated porphyran. 2. The hydrolysate from agarose was separated by gel filtration into the series of neoagarosaccharides, the predominant member of which was the tetrasaccharide. 3. Enzyme action on alkali-treated porphyran gave neoagarosaccharides and other oligosaccharides containing 6-O-methyl-d-galactose units. From the composition of these oligosaccharides it is deduced that action of the enzyme on a d-galactosidic linkage is four to five times faster than on the 6-O-methyl-d-galactosidic linkage. 4. Enzyme action on native porphyran gives a similar series of oligosaccharides but in smaller yield, much of the polysaccharide being either not degraded or only degraded to a series of large, highly sulphated oligosaccharides. 5. For porphyran, it is concluded that 6-O-methyl ether groups are distributed randomly on half the d-galactose units, but that the 6-sulphate groups on l-galactose units tend to occur in blocks.


The specificity of an agarase from a Cytophaga species. 1. The extracellular agarase from a Cytophaga species was shown to have no action on neoagarobiose, neoagarotetraose or their analogues containing 6-O-methyl-d-galactose residues. 2. The action of the enzyme on neoagaro-octaose suggests that scission of the central beta-d-galactosidic linkage, to form two molecules of tetrasaccharide, is the preferred mode of action; however, both exterior d-galactosidic linkages in the octasaccharide and both in neoagarohexaose are hydrolysed at a somewhat lower rate. 3. Sulphated oligosaccharides produced by prolonged enzyme action on porphyran have a minimum degree of polymerization of about 8-10units. 4. For such sulphated oligosaccharides to be further hydrolysed by enzyme action, it is suggested that an unmodified neoagarotetraose residue must be present in the oligosaccharide. 6. A new method for determining the degree of polymerization of these large oligosaccharides is described.


Selective effect of hormones on nucleic acid metabolism during germination of pear embryos. 1. The effect of hormones on (32)P incorporation into various RNA fractions in germinating pear embryos was studied by fractionation on methylated albumin-kieselguhr columns. Abscisic acid inhibited labelling of soluble RNA, DNA-RNA hybrid and light-ribosomal RNA fractions with (32)P and this effect was reversed by both kinetin and gibberellic acid. 2. Kinetin reversed the inhibition by abscisic acid of (32)P incorporation into total ribosomal RNA and appeared to promote labelling of heavy-ribosomal RNA. Gibberellic acid was more active than kinetin in reversing the inhibition by abscisic acid of labelling of the DNA-RNA hybrid fraction with (32)P, but in contrast with kinetin appeared to increase further the inhibition by abscisic acid of labelling of total ribosomal RNA. 3. The percentage of radioactivity in various RNA fractions showed marked variation in response to hormones. 4. The pattern of labelling of RNA in pear embryos during reversal of inhibition by abscisic acid with a combination of kinetin and gibberellic acid was similar to that after cold-treatment of dormant pear embryos. This is suggestive of hormonal interplay in dormancy release by cold-treatment in pear embryos.


The hydrolysis of monolayers of phosphatidyl(Me-14C)choline by phospholipase D. 1. The hydrolysis of monolayers of phosphatidyl[Me-(14)C]choline at the air/water interface by phospholipase D (phosphatidylcholine phosphatidohydrolase) was investigated by a surface-radioactivity technique by using a flow counter. 2. Phosphatidylcholine of high specific radioactivity was prepared biosynthetically in good yield from [Me-(14)C]choline by using Saccharomyces cerevisiae. 3. At initial monolayer pressures between 12 and 25 dynes/cm. the hydrolysis occurred in two stages, an initial slow hydrolysis followed by a rapid hydrolysis. Below 3dynes/cm. and above 28dynes/cm. no enzymic hydrolysis of pure phosphatidylcholine monolayers could be detected. 4. The rapid hydrolysis was proportional to the enzyme concentration in the subphase, its pH optimum was 6.6, and 0.2mm-Ca(2+) was required for maximal activity. 5. Hydrolysis of the film was accompanied by a pronounced fall in the surface pressure even though the phosphatidic acid formed did not leave the film. When the pressure fell to low values the hydrolysis ceased even if the film was only partially hydrolysed. 6. Above monolayer pressures of 28dynes/cm. enzymic hydrolysis could be initiated by inclusion of phosphatidic acid (and less effectively stearyl hydrogen sulphate) in the film, although the rates were not appreciably higher than those observed at 25dynes/cm. with a pure phosphatidylcholine film. 7. The initiation of the hydrolysis by phosphatidic acid was facilitated by the inclusion of high Ca(2+) concentrations and certain carboxylic acid buffer anions in the subphase, although these did not activate by themselves. 8. The initiation of the hydrolysis at high pressures could not be related to any change in the surface potential brought about by the addition of the long-chain anions to the film, nor could it be ascribed to a surface dilution effect. 9. The results are discussed in relation to previous studies on the hydrolysis of phosphatidylcholine particles by the enzyme and also similar investigations on phosphatidylcholine monolayers with other phospholipases.


Binding sites of cholinesterases. Alkylation by an aziridinium derivative. 1. Alkylation of acetylcholinesterase and butyrylcholinesterase by 2-chloro-N-(chloroethyl)-N-methyl-2-phenylethylamine was observed. This alkylating agent was more potent than related compounds previously described, and less stable (half-life 8.5min. at 23 degrees ). 2. Alkylation had effects on hydrolysis of substrates varying from activation for indophenyl acetate to inhibition for acetylcholine, and intermediate effects with five other substrates. The effects were on V(max.) and not K(m). 3. Alkylation caused a variety of changes in sensitivity to inhibition by five carbamates, five organophosphates and four other inhibitors, varying from total protection against tetraethylammonium to mildly enhanced sensitivity to urea. 4. The findings suggested the existence of three binding sites, one of which was anionic and another hydrophobic, in addition to the esteratic site.


Acetylation of serotonin in vitro by a human N-acetyltransferase. 1. There is a well-recognized genetic polymorphism for the N-acetylation of isoniazid and sulphamethazine by human livers. 2. Serotonin was found to be acetylated by human liver enzyme preparations and the N-acetylserotonin formed was identified and determined quantitatively. 3. In 13 livers examined there was a wide variability in the capacity to acetylate serotonin that did not correlate with the capacity of the same livers to acetylate isoniazid and sulphamethazine. The results suggest that serotonin is not a natural substrate for the polymorphic N-acetyltransferase and that it may be acetylated by a different enzyme.


Studies on the biosynthesis of the ergosterol side chain. 1. A convenient synthesis of 24-methylene[23,25-(3)H(3)]dihydrolanosterol is described. 2. A general anaerobic-aerobic method for the incorporation of sterols into whole yeast cells is also described and illustrated by experiments with (3)H-labelled lanosterol. 3. The method was used to convert labelled 24-methylene-dihydrolanosterol into ergosterol, in good yield, by Saccharomyces cerevisiae. 4. Degradation of the biosynthetic ergosterol provided confirmation of the conversion, which supports the proposed mechanism for the biosynthesis of the ergosterol side chain. 5. Mechanisms for the further conversion of the 24-methylene side chain into the ergosterol side chain are discussed and it was shown that a compound, [3alpha-(3)H(1)]-ergost-7-en-3beta-ol, with a fully saturated side chain, can also be efficiently incorporated into ergosterol. 6. This result was confirmed by a procedure involving formation of the 5,8-epidioxide and subsequently the 5,8-epidioxy-22,23-epoxide of the biosynthetic ergosterol.


Biogenesis of oestrogens from (14C)testosterone in the mitochondrial fraction of the human placenta.


The use of carbon dioxide for collecting of ticks.


Control of the profession's education.

Control of the profession's education.


Immunization against whooping-cough.

Immunization against whooping-cough.


Society's rejects.

Society's rejects.


Genetics and infection.

Genetics and infection.


Mental problems in rheumatoid arthritis.


Prevalence, natural history, and relationship of wheezy bronchitis and asthma in children. An epidemiological study. Three randomly selected groups of 7-year-old schoolchildren in Melbourne with mild wheezy bronchitis, with moderate wheezy bronchitis, and with asthma were compared with a control group, and the patients followed up until 10 years of age. Comparison showed that if there was any significant difference between the study groups and the controls it was usually present in all these study groups. It was considered that children with wheezy bronchitis and asthma were from the same population with the same underlying basic disorder, and that there was a wide spectrum in various aspects of the natural history of the disorder.About 11% of all children aged 10 years had had some asthmatic episodes. Seventy per cent. of these children ceased having asthma before 10 years of age, while about 30% (3.7% of the whole community) continued to have episodes. There was a highly significant correlation between early age of onset, the frequency of episodes in the first year of symptoms, and the persistence of asthmatic episodes up to 10 years of age.Ten per cent. of all children with asthmatic episodes continued to have symptoms as severely at 10 years as at an earlier period. In this group the onset of symptoms was almost always before 3 years of age, there was a high frequency of episodes in the first year of symptoms, and boys and girls were affected in the ratio of 7:3.


Epilepsy in prisons: a diagnostic survey. A previous study has suggested that epilepsy is commoner in prisons than in the general population. We devised a standard definition of "epilepsy" and then interviewed a representative sample of the "epileptics" in prisons. The results confirmed the initial conclusion, and showed the point prevalence of epilepsy in prison and Borstals to be at least 7.1/1,000 men.


Action of dopamine on the human iris.

Action of dopamine on the human iris. Dopamine eye drops produce marked dilatation of the pupil in man. This mydriatic effect is inhibited by pretreatment with guanethidine. It is therefore concluded that dopamine acts indirectly via adrenergic nerve endings, rather than exerting a direct effect on adrenergic receptors in the dilator pupillae muscle. In this respect dopamine resembles the phenyl-alkylamines, such as tyramine, rather than the catecholamines, adrenaline and noradrenaline.If dopamine acts by releasing noradrenaline from adrenergic nerve endings, high concentrations of dopamine could lead to depletion of noradrenaline stores, since synthesis might be unable to keep pace with release. This could be the explantion for the orthostatic hypotension found in patients taking L-dopa for Parkinsonism.


Thyroid stimulation test with serum thyroxine concentration as index of thyroid response. A thyrotropin (T.S.H.) test is suggested which relies on the change in the concentration of serum thyroxine as the index of thyroid response to T.S.H. stimulation. Ten such tests have been carried out in healthy volunteers and 39 in patients referred for routine thyroid stimulation tests. Among the advantages of such a test are that the patient does not receive ionizing radiation; it is independent of the presence of iodide-or mercury-containing compounds; and it minimizes the number of patient visits. In remote areas the patient need not attend the specialist centre, because the T.S.H. injection can be given and the serum samples taken locally, the samples then being sent to the appropriate laboratory for assay.


Death due to a combination of treatment and disease.


Testing for phenylketonuria.

Testing for phenylketonuria.


Death and resuscitation.

Death and resuscitation.


Thyroid suppression test with serum thyroxine concentration as index of suppression. A thyroid suppression test is suggested which relies on the change in concentration of serum thyroxine as the index of thyroid response to the administration of triiodothyronine. The test has been carried out in 16 healthy volunteers and in 27 patients referred for routine suppression tests. This index appears to be sensitive and safe and results in a reduction in the required dosage of triiodothyronine. The test can be carried out in fewer patient-visits than the commonly used suppression test; moreover, in remote areas the patient need not attend the specialist centre because the course of triiodothyronine can be given (and the serum samples obtained) locally, the samples then being sent to the appropriate laboratory for assay.


Obstetrics and the general practitioner.


Follow-up after abortion.

Follow-up after abortion.


Premedication for hypotensive anaesthesia.


Hypotensive reaction after propanidid and atropine.


The effect of increased levels of dietary calcium and sodium on the development of hypomagnesaemia in milk-fed calves.


Relationship between corneal radius of curvature and age in rabbits.


Pathophysiology of infections with normal and irradiated metacercariae of Fasciola hepatica.


Erythrocyte glutathione and growth in the calf.


The effect of cortisone on populations of Ostertagia ostertagi of uniform age.


Alteration of glomerular filtration rate in the chicken during intravenous dextrose infusion.


A type of cercaria easily mistaken for Fasciola gigantica in Uganda.


Water and electrolyte balance studies of birds showing "wet droppings".


Microfluorimetric studies on the formaldehyde-induced fluorescence of noradrenaline in adrenergic nerves of rat iris.


A fluorescent method for the detection and localization of zinc in human granulocytes.


Selective labeling of murine amyloid deposits with tritiated tryptophan. An in vivo study.


The effect of pH on the stability of purified glutaraldehyde.


Detection of histamine in mast cells by O-phthalaldehyde reation after liquid fixation.


Morphological change of Pasteurella pseudotuberculosis on tellurite media.


Staphylococcal interference.

Staphylococcal interference.


Intradermal test in the epidemiological survey on bilharziasis in villages near Alexandria, U.A.R.


Heterogeneous system degeneration. Subcortical argyrophilic dystrophy.


Optic glioma of childhood. Natural history and rationale for conservative management.


Toxicity of 1, 8, 9-triacetoxyanthracence to the cornea in rabbits.


Central corneal thickness. Ocular correlations in normal eyes and those with primary angle-closure glaucoma.


Corneal vascularization induced experimentally with corneal extracts.


The visual evoked response in hysterical amblyopia.


Influence of various miotics on cataract formation.


Spontaneous luxation of the eyeballs. Report of a patient with brachycephaly and anomalies of the extraocular muscles.


Aqueous humour vitamin B12 and intramuscular cobalamins.


Relief of chronic epiphora by transantral vidian neurectomy.


Breath-shield modification on Haag-Streit slit lamp.


Spatula for trabeculotomy.

Spatula for trabeculotomy.


Intracellular distribution of basic proteins in the hog renal cortex.


Application of Cu ions for the determination of alpha-amylase in presence of beta-amylase.


Dinema symmetricum sp. n. (Euglenoidina)--parasite of Copepoda from Poland.


The position of Flagellata--parasites of Copepoda in the systematics of Euglenoidina.


The role of Calcium in the action of catecholamine and histamine on the vascular smooth muscles.


The effect of calcium and acidosis on the reactivity of perfused artery segments.


Diurnal fluctuations in the numbers of mitotic and labelled with tritiated thymidine cells of colonic lymphatic noduli of guinea pig.


Clinical course and physical changes of blood in foot-and-mouth S.A.T.2 type infection in cattle.


Some notes on the host specificity of the etiological agents of contagious caprine pleuropneumonia and contagious bovine pleuropneumonia.


Epizootiology of African swine fever virus in warthogs.


Primary pulmonary hypertension in seven young women. Possible connection with taking aminorox fumarate (Menocil).


Effect of intraconjunctival application of pilocarpine on bronchial resistance in asthmatics.


Angiography of the pancreas after injection of secretin and adrenaline.


Intravascular fibrinolysis in the treatment of third-degree burns.


The treatment of hissutism with cyproterone acetate.


Hypopituitarism in sarcoidosis.

Hypopituitarism in sarcoidosis.


Peritoneal dialysis in the treatment of thyrotoxic crisis.


Gastric scanning with technetium 99m.

Gastric scanning with technetium 99m.


Treatment of pseudohypoparathyroidism.

Treatment of pseudohypoparathyroidism.


Plasma expanders and renal function.

Plasma expanders and renal function.


On the epidemiology of influenza. I. Pre-epidemic antibody levels and their relation to some epidemiological characteristics of influenza.


Lack of carcinogenic effects of isonicotinic acid hydrazide in the Syrian golden hamsters.


Overmethylated t-RNAs in human gliomas.

Overmethylated t-RNAs in human gliomas.


Ultrastructural study of Burkitt lymphoma cell lines (EB-2 and EB-3) growing in infant rats.


On lactosepositive variants of Sh. flexneri 2a and serotype 145-46.


Ultrastructure and distribution of neuronal and glial elements on the surface of the proximal part of a motoneuron dendrite, as analyzed by serial sections.


Observations on the ultrastructure of the axon hillock and initial axon segment of lumbosacral motoneurons in the cat.


Ultrastructure of dorsal root boutons on lumbosacral motoneurons of the adult cat, as revealed by dorsal root section.


Observations on the ultrastruture and distribution of neuronal and glial elements on the motoneuron surface in the lumbosacral spinal cord of the cat during postnatal development.


Ultrastructure of the hyphae of Phytophthora palmivora with special reference to intrahyphal hyphae and vesicular elements.


Monocular deviation of the line of writing and its changeability under special conditions.


Marinesco-Sjogren syndrome with myopathy.


EEG in Devic's disease.

EEG in Devic's disease.


Callus formation in cases of cerebral fat embolism (a contribution to the theory of neurogenic influence on osteogenesis).


The effect of streptomycin and colistin on myasthenic patients.


Inner words, dream thought, phantom members.


Bilateral optic atrophy in Charcot-Marie's muscular atrophy.


Relative effects of pregnancy, human placental lactogen and prednisolone on carbohydrate tolerance in normal and subclinical diabetic subjects.


Short-term toxicity of black PN in pigs.


The effect of cyclamate on the hypoglycaemic response of tolbutamide and chlorpropamide in rats.


Acute and short-term toxicity of diacetyl in rats.


Safety evaluation of enzyme detergents. Oral and cutaneous toxicity, irritancy and skin sensitization studies.


Acute and short-term oral toxicity of 2-N-ethylaminoethanol in rats.


Effect of coumarin, BHT and phenobarbitone on protein synthesis in the rat liver.


WHO on drug safety.

WHO on drug safety.


Differential ferrioxamine test in haemochromatosis and liver diseases. The effect of desferrioxamine is examined in more than 100 patients with liver disease, including haemochromatosis, using the differential ferrioxamine test. The procedure gives a reasonably accurate estimate of the size of the iron stores, as determined by multiple venesection, in patients with idiopathic haemochromatosis. Since desferrioxamine is not specific for storage iron, unequivocally abnormal results are not obtained unless the iron load exceeds about 2.3 g. In other forms of liver disease the effect of desferrioxamine is generally increased compared with that in controls. The results show no correlation with the serum iron level or the degree of hepatic siderosis. High values are usual in the presence of jaundice and overlap the range found in untreated haemochromatosis, adding to other evidence that desferrioxamine can derive iron from a hyperchelatable source unrelated to the stores. It is concluded that in liver diseases other than haemochromatosis the results of the test do not reliably reflect body storage iron content.


Postmortem study of the frequency of gallstones in patients with cirrhosis of the liver. The frequency of gallstones in cirrhotic and non-cirrhotic patients at necropsy has been determined from a retrospective survey of postmortem records over 15 years. The frequency of gallstones was found to be 29.4% in the cirrhotic group and 12.8% in the non-cirrhotic population. Whereas gallstones were twice as frequent in females than males in the general population the sex difference disappeared in cirrhotic patients. Gallstones increased in frequency with age in the general population but this phenomenon was not seen in the cirrhotic group. No one type of cirrhosis was more liable to be associated with gallstones at necropsy. In contrast to the general population bilirubin stones were more frequent in cirrhotics.


Significance of increased "splenic uptake" on liver scintiscanning. Peak activity over the spleen as a percentage of peak activity over the liver was measured in 265 (99m)Technetium sulphur colloid liver scintiscans. The value exceeded 70% in 50 cases. In 32 of these cirrhosis was present; the other 18 scans were from patients with a wide variety of conditions, including secondary deposits, hepatitis, and diseases involving the reticuloendothelial system. A measure of the total activity in the spleen was derived from the peak activity and the length of the spleen. In cirrhosis this was closely related to the finding of oesophageal varices thus showing the importance of a collateral circulation (which allows colloid to bypass the liver) in the increased uptake of colloid by the spleen. In eight patients with hepatosplenomegaly due to blood dyscrasia or disease involving the reticuloendothelial system, total activities in the liver and spleen were estimated from the anteroposterior colour dot scan, and both liver and spleen blood flow were measured by methods independent of reticuloendothelial cell function. The results showed that the main factor causing increased uptake of colloid by the spleen in these diseases was an increased blood flow in the spleen relative to that in the liver.


Action of gastrin on the lower oesophageal sphincter in man. Both hog gastrin and synthetic gastrin stimulate the cardiac sphincter to increase tone and augment the resistance to reflux. Endogenous gastrin has a similar effect, and gastrin also stimulates the secretion of acid which has also been found to increase the resistance of the sphincter, but the effect of gastrin appears to be independent of the secretory stimulus.


Gastrointestinal motility and gastric secretion during intravenous infusions of gastrin II. The effect of intravenous infusion of gastrin II on gastric and colonic motor activity was studied in 12 patients; gastric acid output was also measured. Administration of gastrin at near-maximal dose levels stimulates the motor activity of the antrum but has no measurable effect on the activity of the proximal colon, sigmoid, or rectum. The results suggest that gastrin plays a part in the regulation of gastric motility but that it is not a mediator of the gastro-colic reflex.


Response to insulin of the intact stomach in patients with duodenal ulcer. Insulin tests were performed on 47 duodenal ulcer patients with intact stomachs. Only 20 had a positive response to the test judged positive by the criteria of Hollander in the first 45 minutes after the insulin. Twenty became positive between 45 and 60 minutes, and in five the response was not noted until the second hour. Surprisingly, two patients had apparently negative responses to the insulin. While caution is necessary in comparing responses of the intact stomach to those after vagotomy operations, the occurrence of the ;late positive' and negative patterns of response to insulin in the intact stomach may give rise to reservations about the interpretation of these types of response after vagotomy.


Effect of acid infusion into various levels of the intestine on gastric and pancreatic secretion in the cat. Intraduodenal infusion of increasing amounts of hydrochloric acid solution results in a stepwise increase in the volume of pancreatic secretion and output of bicarbonate, reaching about 90% of amounts attained with exogenous secretin infused intravenously in increasing doses. Acid infusion into the different regions of the intestine stimulates pancreatic secretion only from the duodenum and upper jejunum, suggesting that the area of endogenous release of secretin by acid is confined to the upper part of the small bowel in the cat. Gastric acid secretion induced by pentagastrin, but not by histamine, is inhibited by acid perfusion of the duodenum. The acidification of other parts of the small intestine does not result in any change in gastric acid secretion induced either by pentagastrin or by histamine.


Estimation of faecal fat excretion using cuprous thiocyanate as a continuous marker. A method for the estimation of faecal fat excretion using cuprous thiocyanate as a continuous marker is described. Results obtained from a single stool sample are in close agreement with those from a three-day collection using this technique. The method is simpler and more accurate than collections done without a marker.


The long-term effects of end-to-end subclavian-pulmonary arterial anastomosis.


Pendred's syndrome: report of two cases.


An unusual case of calcinosis due to vitamin D intoxication.


Complement titration by rectilinear attenuance and attempts at its automatization.


Temperature effect on antibody production and immunological memory, in carp (Cyprinus carpio) immunized against bovine serum albumin (BSA).


Subpopulations of rat and mouse thoracic duct small lymphocytes in the Salmonella flagellar antigen system.


The development of serum proteins and humoral immunity in opossum "embryos".


Labelling of mouse alloantibody with tritiated dl-alanine.


Social interest and humor.

Social interest and humor.


The relevance of power theme's among male, negro and white, paranoid and non-paranoid schizophrenics.


A social-therapeutic jazz club in England.


Personality and social class position in migration from an island: the implications for psychiatric illness.


Machiavellianism and other personality attributes of psychiatry residents.


A community psychology consultation program in police family crisis intervention: preliminary impressions.


The psychiatric status of 100 men on skin row.


Beyond the half-way house.

Beyond the half-way house.


Some views on individuation.

Some views on individuation.


Individuation and the emergence of the unexpected.


A case of homosexuality.

A case of homosexuality.


High molecular weight fragments of R17 bacteriophage RNA produced by pancreatic ribonuclease.


Determination of the orientation and position of the myoglobin molecule in the crystal of seal myoglobin.


Rate of synthesis along replicons of different kinds of mammalian cells.


Heat of the reaction between polyribocytidylic acid and polyriboinosinic acid.


Community psychiatric services and the general practitioner.


Psychiatry and the general practitioner.


Report of a symposium on psychiatry in general practice. "All the world's a stage".


Some concepts of domiciliary psychiatric practice.


Alcohol in the Highlands and Islands.

Alcohol in the Highlands and Islands.


Effect of the doctor's personality on his style of practice.


The shape of local government.

The shape of local government.


The unity of medical services.

The unity of medical services.


Two streams of medicine?

Two streams of medicine?


Change in local government.

Change in local government.


The medical officer of health in local government.


The local authority and the "Green Paper".


Imported foods.

Imported foods.


Vigilance.

Vigilance.


The Minister of Health's "Green Paper". The point of view of a hospital administrator.


Community care services for the mentally retarded in Britain.


Imported food regulations, 1968. General considerations.


The imported food regulations, 1968. Impending changes.


Executive councils and the "Green Paper".


Radiation at home.

Radiation at home.


Visual aptitude tests with use of KVA tester--a study of the testing method and suggestions for improvement of the standard for judgment.


Fibrinogen metabolism in experimental tumours.


The role of the carrying molecule in the cross-resistance against sugar alcohol derivatives.


Radioimmunoassay of rat prolactin. Comparison of rat prolactin preparations isolated from the "granular fraction" of pituitary tumour transplants and from normal pituitary glands.


Radioimmunoassay of rat prolactin. Prolactin levels in plasma of rats with spontaneous pituitary tumours, primary oestrone-induced pituitary tumours or pituitary tumour transplants.


Growth of tumour cells in diffusion chambers on the chick chorioallantois.


The examination method, equipment, and biometry.


Elements of corneal anatomy and physiology.


Optical and geometric problems in fitting.


Patient selection and fitting procedures for contact lenses.


Fitting special types of patients.

Fitting special types of patients.


Contact lenses. Preface.

Contact lenses. Preface.


On the physiology of spinal dendrites in the cat.


Conditional avoidance in frogs and salamanders.


Spinal electrogram: synchronizing and desynchronizing influences of the brainstem.


Treatment of vitiligo with 1 percent solution of the sodium salt of meladinine using the ionophoresis technique.


Comparative study of local treatment of alopecia areata with trial of two additional methods.


Acute (rat and mouse) and short-term (rat) toxicity studies on isooctyl isodecyl nylonate.


Erysipelothrix rhusiopathiae. Infection in gnotobiotic pigs and rats.


Measles antibodies in patients with various types of measles infection.


Release of neuraminidase from hemagglutinins caused by treatment of influenza viruses with ether. (Brief report).


Action of ethidium bromide on growth of vaccinia virus in rabbits. (Brief report).


Ultrastructure of a freely implanted thyroid.


On the metabolite acidosis resulting from acute hypercapnia.


A possible mechanism for cellular differentiation.


Electrical and contractile activities of the smooth muscles from the stomach in cats.


Anthropometric characteristics of the hard palate in Bulgarians. (Osteological studies).


Ultrastructure of preserved thyroid gland.


Experimental histochemical study of certain dehydrogenases in the receptors of Vater-Pacini.


The weight of the placenta in relation to birthweight.


The onset of abnormal weight gain in toxaemia of pregnancy.


The effect on the fetus of maternal hyperventilation during labour.


Fetal acid-base balance and heart rate during labour with bupivacaine paracervical block anaesthesia.


Levels and significance of 17-oxosteroids and 17-hydroxycorticosteroids in amniotic fluid throughout pregnancy.


Subarachnoid haemorrhage and pregnancy.

Subarachnoid haemorrhage and pregnancy.


Changes in amino acid metabolism during the menstrual cycle.


A clinical trial of isoxsuprine in the treatment of threatened abortion.


An unusual case of recurrent coagulation failure in pregnancy. Treatment with heparin.


Hydrometra and hydrorrhoea in association with endometrial carcinoma.


Metabolic encephalopathies: mechanisms and management.


Functional disorder versus toxic encephalopathy.


Central nervous system disorders related to uremia.


Hepatic encephalopathy.

Hepatic encephalopathy.


Thyroid delirial states.

Thyroid delirial states.


Infectious delirium.

Infectious delirium.


Respiratory infections: new viruses and new techniques.


Immunoprophylaxis in tropical medicine.

Immunoprophylaxis in tropical medicine.


Pseudomonas infection in hospitals.

Pseudomonas infection in hospitals.


Tetanus prophylaxis: clinical aspects.

Tetanus prophylaxis: clinical aspects.


Organisation of field trials of vaccines in England with special reference to measles vaccine.


Observations on the blood concentration of thyrotrophic hormone (T.S.H.) in schizophrenia and the affective states.


Liver circulation and function. Changes in lipids of rat liver following ligation of liver lobe.


A study of biochemical correlates of the affective constitution among Edinburgh business executives.


Alcoholism in the Republic of Ireland.

Alcoholism in the Republic of Ireland.


The significance of age of onset of excessive drinking in male alcoholics.


Liver circulation and function. Observation of enzymatic activity in ligated rat liver lobes.


Phenomenological aspects of the alcoholic "blackout".


Changes in the attitudes to authority of patients with behaviour disorders in a therapeutic community.


E.E.G., memory and confusion in dominant, non-dominant and bi-temporal E.C.T.


Liver circulation and function. Cyto-and biochemical studies of liver glycogen on a liver lobe ligation.


Liver circulation and function. Changes in phosphorylase activity following liver lobe ligation.


The Lincolnshire rehabilitation scheme.

The Lincolnshire rehabilitation scheme.


The complete analysis of a data matrix.

The complete analysis of a data matrix.


Behavioural treatment of non-consumation due to vaginismus.


Aversion therapy for homosexual impulses.


Use of lithium in pregnancy.

Use of lithium in pregnancy.


A cautionary approach to questionnaire response.


A Danish twin study of schizophrenia.

A Danish twin study of schizophrenia.


Obsessive compulsive neurosis in identical twins.


Psychometrically assessed thought disorder in schizophrenic and control patients and in their parents and siblings.


Early vascular injury in the x-irradiated chick embryo: an electron-microscope study.


Atherosclerosis in the Nigerian.

Atherosclerosis in the Nigerian.


Passive transfer and labelling studies on the cell infiltrate in experimental allergic encephalomyelitis.


Plasma bradykininogen levels in adjuvant arthritis and carrageenan inflammation.


The pathology of dyshormonogenetic goitre.


Kinetics of potassium in colonic mucosa of normal and sodium-depleted rats. 1. The transport of K across the mucosal epithelium of the colon of normal and Na-depleted rats has been investigated in vivo by methods involving I.V. administration of solutions containing (42)K and by labelling the mucosa with (42)K from the lumen and observing the ;soaking-out' rates into radionucleide-free solutions.2. During the infusions, the specific activity of the mucosal K was always less than the simultaneous specific activity of the secreted K. On stopping the infusion the specific activity of the mucosal K fell although the plasma specific activity remained at all times greater than that of the mucosa. The blood flow rate to the mucosa estimated from these results was 0.95 ml./min.g wet wt.3. Experiments with (42)K in the lumen showed that the steady-state specific activity of the mucosal K was considerably less than expected if the K had been in a single compartment. The (42)K efflux curves were also consistent in showing two components. The curves were analysed on the basis of a model having two compartments in the mucosa with half-times of 6 and 33 min.4. Na depletion produced two significant changes, (a) K secretion rate doubled, (b) the steady-state specific activity of the mucosal K after luminal exposure to (42)K was increased. The half-times of the compartments were unaffected.5. The results were discussed in terms of a working hypothesis which represented the mucosal K in two compartments. Most of the K exchanges across the mucosa took place through the smaller compartment which probably contained 5% or less of the mucosal K, but which had a rapid turnover rate. The change of K permeability of the luminal face produced by Na depletion and probably due to increased aldosterone action, may well be an important factor in producing the rise of K secretion rate.


Mechanism of stimulation of type J pulmonary receptors. 1. The responses of type J pulmonary receptors (identified according to existing criteria) were studied in anaesthetized cats by recording impulses in individual vagal afferent fibres whose conduction velocity ranged from 0.8 to 7 m/sec.2. Measurements of actual latencies between insufflation of halothane or ether into the lungs and the excitation of the endings, and the latencies before and after circulatory arrest have established that the endings are located in the interstitial tissues close to the pulmonary capillaries. Mainly for this reason, the term juxta-pulmonary capillary receptors (i.e. type J receptors) has been applied to these endings in preference to the term K deflation receptors used hitherto.3. The endings were stimulated by pulmonary congestion produced by occlusion of the aorta or left a-v junction for short periods. They were markedly stimulated during pulmonary congestion following injection of alloxan (150 mg/kg) or the addition of chlorine to the inspired air. This excitation was associated with a marked rise in pulmonary artery pressure and the occurrence of pulmonary oedema. However, the actual onset of excitation occurred some time after the rise in pressure and it was in fact more closely related to fall in pulmonary compliance. The frequency of discharge averaged over about 10-20 sec (in order to take the periods of relative inactivity into account) was 7.5 impulses/sec in 10 fibres (range 0.6-19 impulses/sec; S.D. 6.3). This is intense stimulation of the endings and the congestion so produced is therefore regarded as a severe stimulus for the endings.4. The pattern of excitation was variable. In some fibres the activity consisted of periodic bursts of impulses which seemed to be set off during the deflation phase of artificial respiration, sometimes during the inflation phase. This periodic activity was not due to contraction of smooth muscle as the endings are not stimulated following injection of histamine (into the right ventricle) which is known to stimulate smooth muscles in the alveolar ducts and respiratory bronchioles.5. It is postulated that the actual stimulus for the endings is a rise in interstitial pressure or volume produced by a rise in pulmonary capillary pressure. Evidence has been gathered to show that the latter rises during muscular exercise; this rise must stimulate the endings. It was therefore postulated that stimulation of the endings should cause reflex inhibition of limb muscles (for terminating exercise).


Changes in extracellular potassium concentration produced by neuronal activity in the central nervous system of the leech. 1. Experiments were made on single neurones and glial cells in the central nervous system of the leech to study the accumulation of K that occurs in the extracellular spaces around neurones as a result of impulse activity.2. The resting potential of a neurone is too insensitive to be used for the estimation of small changes in K concentration. The undershoot of the action potential, however, provided a reliable indicator of the K accumulation that occurs around a neurone during activity.3. After a single impluse the amplitude of the undershoot of a second action potential was decreased; the effect corresponded to a peak increase in K concentration of about 0.8 mM/l. immediately after the spike and declined exponentially with a time constant of about 100 msec. With trains of impulses the K concentration increased exponentially, again with a time constant of about 100 msec. The final value of K depended on the frequency and could build up to about double the normal concentration of 4 mM/l.4. The build-up of K was markedly reduced when the extracellular space surrounding a neurone was enlarged by removing its glial investment.5. Synchronous, repetitive activation of groups of neurones caused a slow depolarization of neighbouring glial cells in the C.N.S. of the leech, similar to that observed in amphibia and mammals. The change in glial membrane potential was also used to estimate the changes in K concentration and these values agreed with measurements derived from the undershoot.6. Increases of K concentration in the bathing fluid of the same order as those caused by neural firing markedly affected the frequency of ;spontaneous' neuronal discharges and synaptic potentials occurring within certain neurones in the C.N.S.7. The possible effects of physiologically occurring increases of K concentration on integration are discussed.


After-effects of nerve impulses on signalling in the central nervous system of the leech. A long-lasting hyperpolarization has been observed in sensory neurones of the C.N.S. of the leech following natural stimulation applied to their receptive fields. The underlying mechanism of this hyperpolarization and its effects on signalling were investigated by intracellular recording.1. The amplitude and duration of the hyperpolarization depended on the number of action potentials. Whereas a brief burst of impulses had little effect, a prolonged sensory discharge was followed by a hyperpolarization of up to 30 mV that gradually declined over a period of several minutes.2. The hyperpolarization was abolished by ouabain, reversibly inhibited by strophanthidin or cooling, unaffected by Mg and accompanied by an increase in membrane resistance. These observations suggest that the hyperpolarization is the result of membrane current generated by an electrogenic pump.3. A hyperpolarization similar to that recorded in the cell body also occurred in the neuronal processes within the neuropile, where synaptic contacts are made. This led to significant changes in integrative activity, such as an increase in the amplitude of excitatory synaptic potentials, a reversal of inhibitory synaptic potentials or a conduction block in parts of the neurones. All of these effects could be mimicked by injecting hyperpolarizing currents into resting cells, or abolished by injecting a depolarizing current into a cell hyperpolarized by previous impulses.4. During neuronal hyperpolarization the sensitivity of the membrane potential to small increments of external K was enhanced by a factor of about three. This effect varied with the magnitude of the hyperpolarization produced by preceding impulses and could not be mimicked by applying K to a neurone hyperpolarized by the injection of current into its cell body.5. These findings are discussed in relation to possible effects that changes in the intracellular and extracellular concentrations of ions produced by activity might have on integration in the C.N.S.


The uptake of thyroxine and tri-iodothyronine by perfused hearts. 1. An examination has been made of the uptake of radioactive thyroxine and tri-iodothyronine by the perfused hearts of the rat, rabbit, chicken and frog.2. In all species the uptake of both hormones reaches a steady state at which the uptake of tri-iodothyronine is 2-4 times that of thyroxine.3. The uptake of thyroid hormones by perfused hearts can be resolved into two distinct components-first, an initial transient process which takes up hormone and then releases it with a peak uptake at about 20 min from the beginning of perfusion and second, a basic, slow-uptake process which takes several hours to reach a steady state and which has a greater affinity for tri-iodothyronine. Analysis of the ;initial uptake-and-release effect' suggests that it is due to the presence of plasma thyroxine-binding protein in the interstitial fluid of the heart.4. These two uptake processes provide the basis for the biphasic release of thyroid hormones previously described for the rat heart.


The catecholamine content of hypothalamic nerve cells after acute exposure to cold and thyroxine administration. 1. In female rats, the intensity of the catecholamine fluorescence was determined in nerve cells of the arcuate and periventricular hypothalamic nuclei by means of a microfluorimetrical technique which is based on the fluorescence method of Falck & Hillarp. Frequency distributions were established by grouping the nerve cells according to their fluorescence intensity which was referred to that of a noradrenaline standard.2. When rats were exposed to a cold environment (4 degrees C) on dioestrous day 1, the frequency distribution of relative fluorescence intensity was shifted towards classes of higher fluorescence intensity within 10 min. The mean relative fluorescence intensity and the symmetry of the distribution did not change further during the next 20 min.3. The change in the frequency distribution was almost completely prevented by L-thyroxine (50 mug/kg) administered 3 hr before exposure to cold.4. The direction of the cold-induced change in the frequency distribution is interpreted as reflecting an increase in neuronal activity. Since it was observed in nerve cells which belong to catecholamine-containing tubero-infundibular neurones, it might be related to the release of thyrotropin. Differences in the frequency distributions of the anterior and posterior tuberal regions are discussed with regard to possible functional implications.


Echo-location and evoked potentials of bats after ablation of inferior colliculus. 1. Echo-location and evoked potentials of blinded Yuma bats (Myotis yumanensis) were studied before and after ablation of the inferior colliculus (I.C.). A task of obstacle-avoidance was given to the bats: hits and misses of strands in the flight path were counted. Orientation sounds emitted by the bats during flight were recorded.2. Bilateral ablation of the dorso-medial region of I.C. including the internuclear cortex and commissure had no effect on obstacle-avoidance performance. The bats avoided even strands of 0.2 mm diameter with orientation sounds.3. Bilateral ablation of the dorsal half of I.C. including the external nucleus (lateral cortex) also had no effect on echo-location.4. Bilateral ablation of the ventral half of I.C. caused severe deficiency in ability to avoid obstacles. The main nucleus appeared to be very important for echo-location. When bilateral ablation including the main nucleus was moderate, the bats failed to avoid strands of less than 0.5 mm diameter in spite of detecting them, but avoided large obstacles such as 3.7 mm strands. With severe bilateral ablation including the main nucleus, the bats did not avoid even the 3.7 mm strands in spite of frequent emission of orientation sounds, but often avoided crashing into the wall.5. Severe unilateral ablation of I.C. including the main nucleus and a part of the lateral lemniscus had no effect on ability to avoid obstacles. Since sound localization by such bats are not explained by Van Bergeijk's model based on Békésy's, a modification of Van Bergeijk's model has to be considered.6. Of the positive evoked potentials recorded with an active electrode placed at the dorsal surface of I.C., the slow component with a 7-9 msec peak latency reflected activity of inferior collicular neurones, while the fast component (N(4)) with a 3 msec peak latency represented activity of ascending lateral lemniscal fibres.


The effect of topically applied atropine on resting and evoked cortical acetylcholine release. 1. Cortical acetylcholine (ACh) output was measured in cats anaesthetized either with Dial compound (0.6 ml./kg) or with halothane-N(2)O. ACh output was found to be 1.67 ng/cm(2).min under Dial anaesthesia, and 0.30 ng/cm(2).min under halothane-N(2)O.2. Addition of atropine sulphate (1 mug/ml.) to the collection fluid increased ACh output fourfold under Dial anaesthesia but had no effect under halothane-N(2)O anaesthesia.3. Isolation of the cortex, lesions in the mesencephalon and topical application of tetrodotoxin (TTX) reduced ACh output under Dial anaesthesia to about 0.8 ng/cm(2).min. The effect of atropine on ACh output was somewhat reduced by isolation and completely abolished by mesencephalic lesions or TTX.4. ACh release evoked by reticular formation stimulation under halothane-N(2)O anaesthesia was increased fourfold by atropine but evoked release due to direct stimulation of the cortex was increased only twofold.5. ACh release due to depolarization of the cortex with KCl was not increased by atropine.6. Dihydro-beta-erythroidine (DHE) or D-tubocurarine failed to affect ACh output even in a concentration of 100 mug/ml.7. It is concluded that atropine does not increase spontaneous ACh release and only ACh release evoked by trans-synaptic stimulation of cholinergic neurones is potentiated by atropine.8. These findings are fully consistent with the hypothesis that atropine increases ACh output by blocking cortical cholinergic synapses which are a part of a circuit inhibiting cholinergic neurones.


Hypertension and emotional disturbance.

Hypertension and emotional disturbance.


Two behavioral syndromes in young adults related to possible minimal brain dysfunction.


Longitudinal studies of diurnal excretion patterns in two cases of cyclical affective disorder.


Physiological measures in agitated and retarded depressed patients.


Cum scientia caritas.

Cum scientia caritas.


Communications. Some problems in medical computing in 1969.


The computer and screening techniques in general practice.


Alcoholism treated by systematic desensitization. A follow-up of eight cases.


Carcinoma of lung and bronchus. Incidence in a practice over four years.


The health opinion survey. A psychiatric screening instrument.


Sports injuries of the neck.

Sports injuries of the neck.


The educational needs of the future general practitioner.


The education of the team.

The education of the team.


On the distinction between binding of substrate and kinetic order of addition in enzyme-catalyzed reactions.


Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions.


Biochemical systems analysis. II. The steady-state solutions for an n-pool system using a power-law approximation.


Computing ability of a developmental model for filamentous organisms.


Polyribosomes and unstable messenger RNA: a stochastic model of protein synthesis.


CNDO-2 calculations of the electronic structure of the guanine-cytosine base pair: proton transfer in excited states.


On the structural organization of operon and the regulation of RNA synthesis in animal cells.


A mechanism ffr the amplification of fluctuations in racemic mixtures.


A model for hormone specific activation of adenyl cyclase.


A comment on "A Generalized Functional Role for Phospholipids".


On an analysis of the constant field equation.


The role of glucose in acute laboratory trypanosomal infection.


Observations on foetal haemoglobin in Khartoum hospital.


Electrocardiographic studies in kwashiorkor.


Haemorrhagic pleural effusion in tropical eosinophilia. (A case report).


Observations on the cultivation of Hartmannella castellanii (Douglas) without associated flora.


Renal pathology in acute malaria: a biopsy study.


Effect of long-term electrical stimulations of the hypothalamus on pituitary-target gland systems in rabbits.


Primary afferent depolarization of the trigeminal nerve.


A forceful intracarotid and intravertebral arterial injections of blood for a posttraumatic prolonged coma. A preliminary reort.


Electroencephalographic studies on the lever-pressing behavior rewarded by food.


On the neural mechanism of decision making of lever-pressing.


First records of eye-frequenting Lepidoptera from Nepal.


Burns in Western Nigeria.

Burns in Western Nigeria.


A silastic tendon prosthesis as an adjunct to flexor tendon grafting: an experimental and clinical evaluation.


A new approach to the operation of blepharoplasty.


Free composite lip-switch procedure.

Free composite lip-switch procedure.


Restoration of movement to the upper eyelid in facial palsy.


Congenital tubular nostril (proboscis lateralis).


Stenosis of the nostrils: a report of three cases.


Transplantation of the nail: a case report.


Modified Dingman mouth gag.

Modified Dingman mouth gag.


An improved cranio-maxillary fixation.

An improved cranio-maxillary fixation.


Changes in the pituitary of mice maintained on diets supplemented with various lipids.


The fine structure and development of the nauplius eye of the copepod. Doropygus seclusus Illg.


Cellular changes in the pituitary leading toward tumorigenesis in mice of the C57 B1. strain treated with estrogen.


Lung tumor response in strain A mice as a quantitative bioassay of carcinogenic activity of some carbamates and aziridines.


Warfarin therapy as an adjunct to the surgical treatment of malignant tumors in mice.


Studies on the mechanism of action of anthramycin methyl ether, a new antitumor antibiotic.


The production of hemangioendothelialsarcoma in rats by feeding 5-acetamido-3-(5-nitro-2-furyl)-6H-1,2,4-oxadiazine.


Pathogenesis, histology, and transplantability of urinary bladder carcinomas induced in albino rats by oral administration of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide.


Modification of tumor regression by immunologic means.


Effective means of reducing toxicity without concomitant sacrifice of efficacy of carcinostatic therapy.


Hypersensitivity reactions at tumor sites.


Sensitivity, objectivity and communication.


A room filter for the removal of dust, pollen and air pollutants: preliminary report.


Separate summary for serum proteins in allergic diseases.


Relative sensitivity of methods for measuring airway resistance in asthmatic children.


Comparison of the rotoslide and Durham samplers in a survey of airborne pollen.


Comparison of metaproterenol and isoproterenol aerosols: spirometric evaluation after two months' therapy.


Letters to the editor: interest in allergoid.


Thrombosis.

Thrombosis.


Aspirin, platelets, and bleeding.

Aspirin, platelets, and bleeding.


Aortic homograft valve replacement. A long-term follow-up of an initial series of 101 patient.


Cardiovascular abnormalities following surgery for left-to-right shunts. Observations in atrial septal defects, ventricular septal defects, and patent ductus arteriosus.


Results of repair of tetralogy of Fallot.


Acute pulmonary edema in the absence of left ventricular failure.


Coronary and systemic hemodynamic effects of cardiac pacing in man with complete heart block.


The value of aggressive therapy in the hypertensive patient with azotemia.


Observations on the regulation of cerebral blood flow in complete heart block.


The effects of propranolol on cardiac conduction.


A long-time study of the blood lipids of two students of atherosclerosis.


Termination of paroxysmal junctional tachycardia by right ventricular stimulation.


Localization of the site of myocardial scarring in man by high-frequency components.


Introduction to panel on disturbances of male and female identity as met with in psychoanalytic practice.


Introduction to panel on protest and revolution.


Introduction to panel on psychoanalysis and psychotherapy: the relationship of psychoanalysis to psychotherapy--current issues.


Introduction to panel on language and psychoanalysis.


Narcissistic object choice, self representation.


The self: a contribution to its place in theory and technique.


The non-transference relationship in the psychoanalytic situation.


The psychopathology of the psychoses: a proposed revision.


Towards a basic psychoanalytic model.

Towards a basic psychoanalytic model.


Introduction to panel on child psychoanalysis. The separation-individuation phase: direct observations and reconstructions in analysis.


Introduction to panel on the use of the economic viewpoint in clinical psychoanalysis: the economic point of view and defence.


The nature of the therapeutic action of psychoanalysis.


The development and problems of the theory of the instincts.


A contribution to the ego-psychological critique of the Kleinian school.


A patient's gift: its meaning and function.


The cognitive function of the ego in psychoanalysis. II. Repression, incognizance and insight formation.


Testicular and scrotal masturbation.

Testicular and scrotal masturbation.


Some considerations about transference and countertransference manifestations evoked by the analyst's pregnancy.


The hysteric's experience in psychoanalysis.


The dying patient.

The dying patient.


Observations on the ultrastructure of the initial motor axon segment and dorsal root boutons on the motoneurons in the lumbosacral spinal cord of the cat during postnatal development.


Congenital macrodactyly.

Congenital macrodactyly.


Changes occurring during the growth in Ehrlich ascites cells in vivo.


Changes in the pyruvate kinase and lactate dehydrogenase activity in rat lung during cultivation and "spontaneous" development of malignancy in vitro.


A replication technique for the identification of asbestos fibres in mesotheliomas.


The frequency of constitutional chromosome abnormalities in patients with malignant disease.


The intrapsychic process and its analysis--a recent line of thought and its current implications.


D-xylose test in the marasmic type of protein-calorie malnutrition.


Several views of the self.

Several views of the self.


Familial occurrence of congenital retinal blindness and developmental renal lesions.


Dominantly inherited keratoconus.

Dominantly inherited keratoconus.


Thoughts on the future of human genetics.


Studies on red cell nucleoside triphosphate pyrophosphohydrolases.


Does the human X chromsome show evidence for clustering of genes with related functions?


Idiopathic familial cardiopathy. A study of two families.


Some remarks on the clinical and genetic puzzle of Leber's optic neuritis.


Carrier detection in X-linked muscular dystrophy.


Changes in the electrolytes, urea and osmolality of the amniotic fluid with advancing pregnancy.


Comparison of frontal and mastoid bone-conduction thresholds in various conductive lesions.


The effects of nuclear explosions on modern cities.


Alternative de novo and "salvage" pathways to thymidine triphosphate synthesis: possible implications for cancer chemotherapy.


The excretion of extremely polar unconjugated corticosteroids in normal and pathological pregnancy. A preliminary study.


Lecithin-protein interaction in the GTP-dependent acyl-CoA synthase.


Bullous pemphigoid of childhood and coeliac disease. Report of a case.


Oxygen dissociation curves of the bloods of maternal and fetal goats as they exist in vivo.


Crime and mental illness in a group of psychopathic personalities.


Trial of chlorpromazine for the prevention of the central nervous system side effects of niridazole.


Vernal keratitis.

Vernal keratitis.


Ocular toxoplasmosis (case report).

Ocular toxoplasmosis (case report).


Why diabetic children go to summer camp.


Hiatal hernia and gastroesophageal reflux. A clinicoradiological analysis of more than 1,000 cases.


Acid-base and electrolyte disturbances in hepatic coma.


Recent trends in hospitalization and disability from mental disorders.


The use of hyperbaric oxygen in clinical medicine.


Transmission technique used for positioning for cerebral blood flow.


Interstitial irradiation of the pituitary gland with a 90Sr--90Y applicator having adjustable active length.


Spontaneous aortico--left ventricular fistula associated with myxomatous transformation.


Differential labelling of ribonucleic acid in subfractions of rye (Secale cereale) leaf mitochondria.


Steady state levels of dehydrogenases and alpha- and beta-glucosidases in Klebsiella aerogenes.


Lactic acid and the phlogiston debt.

Lactic acid and the phlogiston debt.


Leontiasis ossea: (a case report).

Leontiasis ossea: (a case report).


The development of the placenta in the sheep and goat: an electron microscope study.


Metabolism of [U-14C]glucose in the rat uterus in the presence of an intra-uterine contraceptive device.


Thrombocytopenic purpura and carcinoma of the stomach in old age.


Protein binding and lipophilic nature of ataractics of the meprobamate- and diazepine-group.


Considerations in genetic counseling.

Considerations in genetic counseling.


Social aspects of medicine with special reference to pediatrics.


Bridging the gap. Quality control in obstetrics.


The dog heartworm: a possible problem in man.


Diagnosis of anatomical lesions in children with urinary tract infections.


Lupus erythematosus and hyperthyroidism.


Vitamin B 12 dependent methionine biosynthesis in cultured mammalian cells.


Cell wall polymers of Bacillus sphaericus 9602. I. Structure of the vegetative cell wall peptidoglycan.


Solid-phase syntheis and some pharmacological properties of [8-phenylalanine]-oxytocin.


Equilibrium mechanochemistry of collagen fibers.


Enzymatic replacement of the arginyl by a lysyl residue in the reactive site of soybean trypsin inhibitor.


Ultraviolet difference spectrl studies of conalbumin complexes with transition metal ions.


Circular dichroism and absorption spectra of horse radish peroxidase and sperm whale myoglobin in the Soret region.


Zinc isotope exchange in horse liver alcohol dehydrogenase.


The amino acid sequence of bovine carboxypeptidase A. II. Tryptic and chymotryptic peptides of the cyanogen bromide fragment F-III.


The amino acid sequence of bovine carboxypeptidase A. 3.


Glycerol-3-phosphate dehydrogenase. I. Fluorescence behaviour of the p-CMB inactivated enzyme.


Sternomastoid tumour and muscular torticollis.


Effect of photoperiod on patterns of oviposition of Anocentor Nitens Neumann (Acarina: Ixodidae).


Three new species of Guntherana Womersley and Heaslip (Prostigmata: Trombiculidae) from East New Guinea.


Ixodes taglei n. sp. (Acarina: Ixodidae) a parasite of the deer, Pudu pudu (Wol.), in Chile.


Endoparasitic chiggers. V. New genera, species and records from Venezuela and Brazil (Acarina: Trombiculidae).


Amino acid patterns during digestion in the small intestine of ducks.


Effect of excess amino acids on the utilization of the first limiting amino acid in chick diets.


On the protective action of zinc against experimental liver damage due to choline free diet or carbon tetrachloride.


Pulmonary coin lesion containing a horse bot, Gasterophilus. Report of a case of myiasis.


Kinetic studies of the action of cellulase upon sodium carboxymethyl cellulose.


Student unrest in secondary schools.

Student unrest in secondary schools.


Fluorescence decay time characteristics of the complex between ethidium bromide and nucleic acids.


Reduction and reoxidation of the disulfide bonds of bovine serum albumin.


Character of placentation in twins, as related to hemoglobin levels.


Relationship of hygiene, milking machine function, and intramammary therapy to udder disease.


The effect of interspecies contact upon diarrhea morbidity and salmonellosis in children.


Vibriocidal antibody in clinical cholera.


Rabies in citizens of the United States, 1963-1968: epidemiology, treatment, and complications of treatment.


Inhibition of Ehrlich ascites tumor growth by nucleoprotein. I. In vivo characterization and presumptive chemical identification.


In vivo oxidation of glucose-1-14C and glucose-6-14C in mice with 7,12-dimethylbenz-[a]anthracene-induced tumors.


A cytogenetic study of D-D translocation in two families.


Teratogenic action of hypoxia on the chick embryo. II. Malformations observed in the eighteen-day-old embryo.


Electrocardiogram of the rainbow trout and its radio transmission.


Minimum medium for Corynebacterium renale and filamentous growth due to deficiency or excess of inorganic ions.


The importance of foetal physiology and endocrinology in obstetrics.


Central pontine myelinolysis.

Central pontine myelinolysis.


Hydatid control. A problem in health education.


The pupillogram and narcolepsy. A method to measure decreased levels of wakefulness.


Excitability of motoneurons in infants.

Excitability of motoneurons in infants.


Separate and combined effects of phenol, hyaluronidase, and dimethyl sulfoxide on the sciatic nerve of the rat. II. Chronic studies.


Evidence for a Pasteur effect regulating cerebral oxygen and carbohydrate metabolism in man.


Migraine associated with hyper-pre-beta lipoproteinemia.


Aspergillosis of the central nervous system. Report of a brain abscess due to A. fumigatus and review of the literature.


Spinal fluid creatine kinase in neurologic disease.


Chromobacterium violaceum infection in pigs.


Palatal myoclonus and rhythmic ocular movements: a polygraphic study.


Storage of cysticerci of Taenia hydatigena and its effect on the recovery of worms from dogs.


Death claim payments near 900,000,000 dollars in 1968.


Incorporation of [3H] thymidine into the DNA of brain, liver, spleen and submaxillary salivary gland in normal and scrapie-affected mice.


Substitution of lipids with bile salts in the formation of thrombin.


Some properties of the anticoagulant factor of aged pooled plasma.


Histomonas in the bird and in the nematode Heterakis.


Investigations of possible sub-lethal effects of DDT on oögenesis in houseflies.


Tissue reactions to Schistosoma mansoni eggs. I. Serological and histological reactions at various intervals after infection.


A study to investigate the pathogenicity of a parasite resembling Acanthocheilonema perstans.


A new paper chromatography solvent system resolving pyrimidine-pyrimidine riboside-pyrimidine deoxyriboside mixtures.


The relation of measured intelligence to birth weight and duration of gestation.


Use of a non-carcinogenic reagent for the determination of blood glucose.


Infantile autism in Australia.

Infantile autism in Australia.


Cesarean section.

Cesarean section.


Effect of heating and cooling on interaction of lysine-rich histones with deoxyribonucleic acid.


Reversible adsorption of enzymes as a possible allosteric control mechanism.


Radiotherapy in the treatment of sarcomas of the corpus uteri.


Enhancement of respiration in the sea urchin egg by a subthreshold stimulation with an activating reagent.


Induction of nuclear changes and cleavage by repeated insufficient stimulations with activating reagents in the sea urchin egg.


Ultrastructural changes in the surface of the oocyte during oogenesis of the sea urchin, Hemicentrotus pulcherrimus.


Acceleration of cleavage in sea urchin eggs by repeated insufficient stimulations with various activating reagents and spermatozoa.


Propagation of the fertilization-wave on the once-activated surface of the sea urchin egg.


Non-gametic factors involved in the fertilization of Bufo arenarum oocytes.


Effect of magnesium on the response of the rat mammary gland strip to oxytocin analogues.


The effect of ethanol and carbon tetrachloride administration on hepatic lipid-soluble antioxidant activity.


Protection of mice against infection by Staphylococcus aureus.


A novel composition of phosvitins from salmon and trout roe.


Metabolism of the lipoproteins of serum by leptospires: degradation of the triglycerides.


Long-term culture of mouse peritoneal macrophages with special reference to proliferation.


Linking of cardiac and respiratory rhythms in newborn babies.


The transmural potentials in the functional oviduct of the hen.


Residues of endrin and DDT in soybeans grown on soil treated with these compounds.


DDT residues in tobacco and soybeans grown in soil treated with DDT.


Residues of DDT and endrin in peanuts and soybeans grown in soil containing these pesticides.


Fetal environment and its influence on fetal development.


Effect of raw soybean flour on vitamin B12 requirement on rats.


Hazards from raw fish.

Hazards from raw fish.


Poultry mite infestation.

Poultry mite infestation.


The circadian rhythm of flight activity in the mosquito Aedes aegypti (L.). The phase-setting effects of light-on and light-off.


Chronic manganese poisoning. Individual susceptibility and absorption of iron.


Studies of delayed dermal hypersensitivity in patients with subacute sclerosing panencephalitis.


On the probability that a twin pair is monozygotic.


Studies on chromosomal nondisjunction in man. 3.


Fertility of mothers with twins.

Fertility of mothers with twins.


N-Acylphosphatidylethanolamines: occurrence in nature, structure and stereochemistry.


Operational experience of a large urban neonatal referral unit.


The influence of alcohol on viral and isoproterenol cardiomyopathy.


Social introversion--extraversion as a heritable response.


Some acute effects of administered porcine calcitonin in man.


Toxemia of pregnancy in sheep: a clinical, physiological, and pathological study. Toxemia was induced in 13 of 20 pregnant ewes by the stress of a change in environment and food deprivation late in pregnancy. Of the toxemic ewes, eight developed prominent neurological findings with convulsions, motor weakness, and blindness, whereas five ewes developed azotemia without neurological signs. Proteinuria and azotemia occurred in all but one of the toxemic animals. Seven animals did not develop clinical or laboratory evidence of toxemia. Hypertension did not occur with the onset of toxemia but all toxemic animals showed glomerular changes by light and electron microscopy. These abnormalities, which were similar to those seen in human preeclampsia, included endothelial cell swelling, focal reduplication of the basement membrane, and fusion of the epithelial cell foot processes. The toxemia could not be attributed to changes in hematocrit, plasma glucose, Na, Cl, CO(2), K, Ca, fibrinogen, arterial pH, lactate, or pyruvate concentrations. Cardiac output fell only in ewes with prominent neurological signs. Plasma renin rose strikingly in animals developing toxemia, without change in substrate concentration. In contrast to human and other species, sheep uterus and amniotic fluid contained no detectable quantities of renin. Thus in response to stress the pregnant ewe develops a toxemia which in the absence of hypertension has clinical and pathological similarities to human preeclampsia.


Alienation and the will to live.

Alienation and the will to live.


Failure of nitro blue tetrazolium reduction in the phagocytic vacuoles of leukocytes in chronic granulomatous disease. The leukocytes of patients with chronic granulomatous disease (CGD) may be identified by their failure to reduce Nitro Blue Tetrazolium (NBT) during phagocytosis. This reaction, normally detected in the phagocytic vacuole, is absent or delayed in CGD monocytes and eosinophils as well as in neutrophils, even though sonicates of normal and CGD leukocytes contain equal activities of a cyanide insensitive enzyme system capable of reduction of NBT in the presence of pyridine nucleotide. Enlargement of CGD phagocytic vacuoles appears to be inhibited. Histochemical estimates of the rate of release of alkaline phosphatase are normal in CGD cells. Peroxidase activity is released from CGD cells, but the rate appears to be somewhat slower than normal in some cases. The latter observation may be explained by the increased intensity of the peroxidase stain in resting and phagocytizing CGD cells. The severity of the defect in NBT reduction within the phagocytic vacuoles of the leukocytes of patients and carriers is more variable than was previously appreciated. Some female carriers have profoundly reduced dye reduction and others are nearly indistinguishable from normal. Three brothers with CGD demonstrated significant, albeit delayed, NBT reduction in phagocytic vacuoles during prolonged incubation of their leukocytes. No obvious relationship exists, however, between the rate of reduction of NBT in vacuoles and the clinical severity of the disease.


Vertical cutaneous organization.

Vertical cutaneous organization.


Studies on motile, nontubule-containing, filiform spermatozoa of the ostracod Cypridopsis. I. Spermiogenesis.


Solid-phase radioimmunoassay of human placental lactogen.


Urethrovesical needle suspension: postoperative loss of vesical neck support demonstrated by chain cystography.


Dysfunctional labor due to fecal impaction. Report of a case.


Amniotic fluid filtration and cytology.

Amniotic fluid filtration and cytology.


Biochemical studies of the fetus. 3. Fetal base and Apgar scores.


Gas in the superior sagittal sinus of the dead fetus.


Hydrocephaly following fetal X irradiation.


Uterine cervix marker.

Uterine cervix marker.


On the glycocalyx, the external coat of the plasma membrane, of some secretory cells.


The nature of strong binding between acridine orange and deoxyribonucleic acid as revealed by equilibrium dialysis and thermal renaturation.


Species specificity of the low molecular weight nuclear RNA's.


Sedimentation properties of ribosomal particles in Dictyostelium discoideum.


Acute (rat and mouse) and short-term (rat) toxicity studies on isoocyl isodecyl nylonate.


The yolk of Holostean fishes.

The yolk of Holostean fishes.


Studies of clomiphene effects on rabbit embryo development and biosynthetic activity.


Report on the present-day medical and economic importance of measles in Czechoslovakia.


Changes during clomiphene citrate therapy. A study of basal body temperature, cervical mucus, vaginal cytology, spermatic penetration, and duration of menstrual cycle.


The lyophilization of measles virus.

The lyophilization of measles virus.


Chondrogenesis in chick embryo somites in vitro.


Effect of carbonic anhydrase inhibitor on tubal ova.


Haemagglutination-inhibiting antibodies to arboviruses in the human population in Thailand.


Studies on the ecology of antibiotic-resistant staphylococci.


Concentration and purification of haemagglutinin of three types of Myxovirus parainfluenzae by means of chemical methods.


Postvaccination anti-typhoid immunity after primary immunization and revaccination according to the results of controlled field trials.


Oestrus induction in ewes.

Oestrus induction in ewes.


The acute and chronic effects of pharmacological adrenergic blockade in obstructive cardiomyopathy.


Treatment for intestinal cappallariasis.


A laboratory survey of A-B-O blood-group incompatibility and neonatal jaundice.


The immunogenicity of a multicomponent clostridial oil emulsion vaccine in sheep.


A note on the intraperitoneal injection of sheep with oil adjuvant vaccines.


Studies on the activity of nitroxynil against fasciola gigantica in naturally infected buffaloes, cattle and sheep.


Thoracic repair of a diaphragmatic hernia in a heifer.


Anthrax: a problem of the livestock industry.


Correspondence scientific, toxocara canis as a support for cholelithiasis in the dog.