Partial purification and kinetics of oestriol 16 alpha-glucuronyltransferase from the cytosol fraction of human liver. An enzyme that conjugates the 16alpha-hydroxyl group of oestriol with glucuronic acid was found in the cytosol fraction of human liver. The enzymic activity could not be sedimented when the cytosol fraction was centrifuged at 158000g(av.) for 120min. The oestriol 16alpha-glucuronyltransferase was purified 100-fold by 0-30% saturation of the cytosol fraction with ammonium sulphate followed by filtration of the precipitate through Sephadex G-200. The activity was eluted at the void volume. The product of the reaction, oestriol 16alpha-monoglucuronide, was identified by paper chromatography and by crystallization of radioactive product to constant specific radioactivity. The optimum temperature was 37 degrees C, and the activation energy was calculated to be 11.1kcal/mol. The apparent Michaelis-Menten constants for oestriol and UDP-glucuronic acid were 13.3 and 100mum respectively. Cu(2+), Zn(2+) and Hg(2+) inhibited, whereas Mg(2+), Mn(2+) and Fe(2+) stimulated the enzyme. Substrate-specificity studies indicated that the amount of oestradiol-17beta, oestradiol-17alpha and oestrone conjugated was not more than about 5% of that found for oestriol. Oestriol 16alpha-monoglucuronide, a product of the reaction, did not inhibit the 16alpha-oestriol glucuronyltransferase; in contrast, UDP, another product of the reaction, inhibited the enzyme competitively with respect to UDP-glucuronic acid as the substrate, and non-competitively with respect to oestriol as the substrate. ATP and UDP-N-acetylglucosamine did not affect the oestriol 16alpha-glucuronyltransferase. 17-Epioestriol acted as a competitive inhibitor and 16-epioestriol as a non-competitive inhibitor of the glucuronidation of oestriol. 5alpha-Pregnane-3alpha,20alpha-diol also inhibited the enzyme non-competitively. It is most likely that the oestriol 16alpha-glucuronyltransferase described here is bound to the membranes of the endoplasmic reticulum.


Glutaraldehyde-insolubilized concanavalin A: an adsorbent for the specific isolation of polysaccharides and glycoproteins.


The physiological role of liver alcohol dehydrogenase. 1. Yeast alcohol dehydrogenase was used to determine ethanol in the portal and hepatic veins and in the contents of the alimentary canal of rats given a diet free from ethanol. Measurable amounts of a substance behaving like ethanol were found. Its rate of interaction with yeast alcohol dehydrogenase and its volatility indicate that the substance measured was in fact ethanol. 2. The mean alcohol concentration in the portal blood of normal rats was 0.045mm. In the hepatic vein, inferior vena cava and aorta it was about 15 times lower. 3. The contents of all sections of the alimentary canal contained measurable amounts of ethanol. The highest values (average 3.7mm) were found in the stomach. 4. Infusion of pyrazole (an inhibitor of alcohol dehydrogenase) raised the alcohol concentration in the portal vein 10-fold and almost removed the difference between portal and hepatic venous blood. 5. Addition of antibiotics to the food diminished the ethanol concentration of the portal blood to less than one-quarter and that of the stomach contents to less than one-fortieth. 6. The concentration of alcohol in the alimentary canal and in the portal blood of germ-free rats was much decreased, to less than one-tenth in the alimentary canal and to one-third in the portal blood, but detectable quantities remained. These are likely to arise from acetaldehyde formed by the normal pathways of degradation of threonine, deoxyribose phosphate and beta-alanine. 7. The results indicate that significant amounts of alcohol are normally formed in the gastro-intestinal tract. The alcohol is absorbed into the circulation and almost quantitatively removed by the liver. Thus the function, or a major function, of liver alcohol dehydrogenase is the detoxication of ethanol normally present. 8. The alcohol concentration in the stomach of alloxan-diabetic rats was increased about 8-fold. 9. The activity of liver alcohol dehydrogenase is generally lower in carnivores than in herbivores and omnivores, but there is no strict parallelism between the capacity of liver alcohol dehydrogenase and dietary habit. 10. The activity of alcohol dehydrogenase of gastric mucosa was much decreased in two out of the three germ-free rats tested. This is taken to indicate that the enzyme, like gastric urease, may be of microbial origin. 11. When the body was flooded with ethanol by the addition of 10% ethanol to the drinking water the alcohol concentration in the portal vein rose to 15mm and only a few percent of the incoming ethanol was cleared by the liver.


Cellular growth in specific nutritional deficiency states in rats. I. Iron deficiency anaemia in post-weanling period.


Placental transport of iron in X-linked anaemia of mice.


Rat mammary-gland acetyl-coenzyme A carboxylase interaction with milk fatty acids. 1. Highly purified rat mammary-gland acetyl-CoA carboxylase was inhibited by milk obtained from rats 12h after their young were weaned. 2. All the inhibitory activity was found in the particulate fraction (R(105)) obtained on centrifuging the milk. It could be extracted from milk fraction R(105) with acetone and identified as a complex mixture of non-esterified fatty acids, present in high concentration (nearly 10mm) in the milk. 3. Inhibition of acetyl-CoA carboxylase was observed at low concentrations (0.2-20mum) of several of these fatty acids when fresh fully active enzyme was used. Enzyme that had been partly inactivated by aging, or by storing in the absence of citrate, was stimulated by low concentrations but inhibited by high concentrations of fatty acids. 4. Various experiments suggested that fatty acids produce irreversible inactivation of acetyl-CoA carboxylase. 5. The effects of palmitoyl-CoA on mammary-gland acetyl-CoA carboxylase were found to resemble those of fatty acids, except that palmitoyl-CoA was effective at lower concentration. 6. The effect of milk fraction R(105) was tested on six other enzymes previously shown to decline to various extents after weaning. Although several of these enzymes were affected by unfractionated milk fraction R(105), none was significantly inhibited by the acetone extract or by low concentrations of lauric acid. 7. The findings are consistent, both qualitatively and quantitatively, with a regulatory mechanism whereby milk fatty acids shut off fatty acid synthesis in the mammary gland after weaning by inhibiting acetyl-CoA carboxylase.


Enzymatic diagnosis of megaloblastic anaemia.


The use of reticulocytes with high non-haem iron pool for studies of regulation of haem synthesis.


Erythrocyte glutathione-peroxidase deficiency.


Milder variant of sickle-cell disease in Arabs in Kuwait associated with unusually high level of foetal haemoglobin.


Pharmacological studies of Bufexamac topically applied on the skin.


Irreversibly sickled cells and splenomegaly in sickle-cell anaemia.


Progress in physiotherapy.

Progress in physiotherapy.


Length of gestation.

Length of gestation.


Problems of rectal prolapse.

Problems of rectal prolapse.


Absence from work.

Absence from work.


In time of need.

In time of need.


Hereditary defect in the platelet release reaction caused by a deficiency in the storage pool of platelet adenine nucleotides.


Juvenile spondylarthritis.

Juvenile spondylarthritis.


Hidden hyperthyroidism.

Hidden hyperthyroidism.


Fallacy of the fundal height.

Fallacy of the fundal height. The method of estimating gestational age from the height of the fundus uteri during pregnancy has been investigated. Such wide variations occur in the length of the maternal abdomen and umbilical position and in the level of the uterine fundus at each gestational age that the method is not reliable. Assessment of uterine size by pelvic examination in the first trimester of pregnancy correlates more closely with gestational age than assessments made by abdominal palpation of the uterus at a later time.


Serum fibrin-fibrinogen degradation products associated with postoperative pulmonary embolus and venous thrombosis. A total of 76 "high-risk" surgical patients were studied for evidence of venous thromboembolic disease. Episodes of deep vein thrombosis and of pulmonary embolism were related to changes in blood levels of fibrin degradation products (F.D.P.). When diagnosed either by ordinary clinical means or by venography and isotope scanning significantly raised F.D.P. levels were found in all cases. Serum F.D.P. estimations are unlikely to help in detecting deep vein thrombosis, but may prove valuable in diagnosing pulmonary embolism.


Acetate and bicarbonate in the correction of uraemic acidosis. Uraemic acidosis was readily corrected by the infusion of sodium acetate solution, which gave comparable results to equivalent amounts of sodium bicarbonate infusion. Preliminary data suggest that this was true even in severe liver disease.


Spironolactone diuresis in patients with cirrhosis and ascites. Increased aldosterone levels with consequent or diuretic-potentiated electrolyte abnormalities are an important consideration when patients with cirrhosis and ascites undergo diuresis. A simple clinical method using the urinary Na/K ratio as a guide to spironolactone dosage is outlined. Patients with a ratio greater than 1 responded well to 100 mg. of spironolactone a day; those when it was one or less responded well to 200 to 1,000 mg. a day.Administration of spironolactone alone (11 patients) or as the main diuretic (three patients) was a safe and effective means of inducing sustained uncomplicated diuresis in all these patients.


Endocrine function in male and female homosexuals. Serial assays of hormones and their metabolites are reported in the urine of three male and four female homosexuals. Urinary testosterone levels were abnormally low in the two men who practised exclusive homosexuality and were within the normal range in the third, who had both homosexual and heterosexual relationships. In the women assays were generally performed throughout one menstrual cycle; in three the pattern of hormone excretion was ovulatory in character, while in the fourth evidence for ovulation was equivocal. Levels of testosterone and luteinizing hormone (L.H.) were raised in the female homosexuals, while those for oestrogens, particularly oestrone, were below the range for normal heterosexual subjects during their reproductive life; readings of follicle-stimulating hormone (F.S.H.) and pregnanediol were normal in three women. The data reported here are in keeping with the view that abnormalities in endocrine function may occur in both male and female homosexuals.


Combined rifampicin and erythromycin for bacterial endocarditis.


Immunological factors affecting tumour growth.


Host defence mechanisms in Burkitt's lymphoma and Kaposi's sarcoma: the clinical evidence.


Accident and emergency services.

Accident and emergency services.


Emphysema in coalworkers.

Emphysema in coalworkers.


Maternal phenylketonuria.

Maternal phenylketonuria.


Gangrene of digits.

Gangrene of digits.


Prophylactic lithium.

Prophylactic lithium.


Fibrin degradation products.

Fibrin degradation products.


Myocardial infarction and the G.P.

Myocardial infarction and the G.P.


Outbreak of El Tor cholera in Istanbul.

Outbreak of El Tor cholera in Istanbul.


Coats' disease, diagnosis and treatment.


Haemorrhage on the disc--a sign of acute ischaemic optic neuropathy in chronic simple glaucoma.


Trachoma in private practice in Western Australia.


Congenital fibrosis syndrome.

Congenital fibrosis syndrome.


The A-wave of the rabbit electroretinogram.


Orbital extension of meningioma.

Orbital extension of meningioma.


Severe aplastic anemia as a complication of acetazolamide therapy.


Pedunculated malignant melanoma of conjunctiva.


Oscillatory potentials: a clinical study in diabetics.


Variation in urinary creatinine excretion and its relationship to measurement of urinary 17-hydroxycorticosteroids.


Labeling with indocyanine green of serum protein from normal persons and patients with acute viral hepatitis.


Biological and analytic components of variation in long-term studies of serum constituents in normal subjects. I. Objectives, subject selection, laboratory procedures, and estimation of analytic deviation.


Biological and analytic components of variation in long-term studies of serum constituents in normal subjects. II. Estimating biological components of variation.


An automated, saccharogenic method for determining serum amylase activity.


Assessment of two blood-analyzer systems intended for diagnostic testing in the physician's office.


Biological and analytic components of variation in long-term studies of serum constituents in normal subjects. 3. Physiological and medical implications.


Measurement of total calcium in serum by atomic absorption spectrophotometry, with use of a strontium internal reference.


Adverse drug reactions: a pharmacist-based monitoring system.


Comparative effects of smoking marihuana or placebo on human motor and mental performance.


Breed susceptibility to tryptophan-induced pulmonary adenomatosis in cattle.


Effects of exercise on certain electrocardiographic parameters and cardiac arrhythmias in the horse. A radiotelemetric study.


Correlation of heterophil agglutinins with the complete blood counts of auction calves.


Swine abscesses caused by Lancefield's group E streptococci. VII. Specificity of the precipitin test for their detection with relation to streptococcal antigens of groups C and L.


The enterohepatic circulation in glutethimide intoxication.


Standard oral water load to determine the site of action of diuretics in man. With data on metolazone, a new diuretic.


Disposition of bretylium in man and rat. A sensitive chemical method for its estimation in plasma and urine.


Flumethasone pivalate (Locorten). Anti-inflammatory, antipruritic.


Unwanted effects of pentagastrin.

Unwanted effects of pentagastrin.


Comparative stimulant and diuretic actions of caffeine and theobromine in man.


Peripheral facial-nerve paralysis and its surgical treatment.


The effect of chlorpromazine on serum cholesterol in chronic schizophrenic patients.


One-stage correction of subglottic stenosis.


Prazepam metabolism by man.

Prazepam metabolism by man.


Traumatic luxation of the globe.

Traumatic luxation of the globe.


Tracheal stenosis following the use of the cuffed tracheotomy tube.


Retinal perforation and muscle surgery.

Retinal perforation and muscle surgery.


Management of the dry eye using scleral lenses (a report on 66 cases).


Benefits for office practice using tropicamide--a short acting mydriatic-cycloplegic.


Removal of vitreous from the anterior chamber in vitreo-corneal adhesions.


Ophthalmology at the University of Tennessee College of Medicine.


On some present concepts regarding acute respiratory infection.


Correction of ametropia in skin and scuba divers.


Eye tissue transplantation in children.

Eye tissue transplantation in children.


Neurophysiological studies on wearing contact lenses.


Deep perforating injury of the orbit.

Deep perforating injury of the orbit.


Aural rehabilitation for a population of hearing impaired adults.


Evaluation of diphenidol in the symptomatic treatment of labyrinthine vertigo.


The investigation of headaches.

The investigation of headaches.


The International Eye Foundation.

The International Eye Foundation.


Tear-gas pens may cause permanent eye damage.


Congenital cataract: surgical and visual problems--two decades of developments.


The use of applanation tonometer massage in formation of filtering blebs.


Eye care in state institutions for the mentally retarded.


A guide to the Wilmer Institute, Johns Hopkins Hospital.


Trauma to the cartilaginous skeleton of the nose.


Lipoflavonoids in Ménière's disease.

Lipoflavonoids in Ménière's disease.


Adhesive otitis media. An approach to its treatment.


Central air-conditioning system may be a public health hazard.


Practically speaking: glaucoma problems and ramifications.


Psychology of blindness.

Psychology of blindness.


The fiber optics indirect ophthalmoscope.


Cataract operation on the institutionalized elderly.


Correlation between ophthalmodynamometry and arteriography in diagnosing carotid occlusive disease.


Allergies may lead to minimal brain dysfunction in children.


Management of malignant lymphoma of the Waldeyer's ring by irradiation.


The case of the unfortunate construction worker.


Devers Memorial Eye Clinic.

Devers Memorial Eye Clinic.


Stepping test.

Stepping test.


Audiologic findings in serous otitis media.


The crooked or twisted nose.

The crooked or twisted nose.


Vacuum headache.

Vacuum headache.


Aspirin intolerance.

Aspirin intolerance.


An unusual malignant melanoma of the choroid affected by prednisone.


Cataract extraction still a major procedure.


Malignant hyperpyrexia.

Malignant hyperpyrexia.


Residency Training Program in ophthalmology Presbyterian-St. Luke's Hospital.


The management of orbital tumors with emphasis on diagnosis by venography.


The biophysics of light energy and the eye.


The return of function after damage to the facial nerve.


Residency Program Department of Ophthalmology Evanston Hospital, Evanston, Illinois.


Torsion swing and galvanic test. Comparative evaluation of two neglected vestibular tests.


A review of carcinoma of the larynx in a large veterans hospital from 1950 through 1960.


Some physiologic correlations between labyrinth and retina.


Severe asthma attacks caused by gnats and box elder bugs.


Cancer of the tonsilar area.

Cancer of the tonsilar area.


Emergency airway for acute laryngeal obstruction.


Physical therapy for children with intractable asthma.


Absolute profile visual field studies with the Tubingen perimeter in normal subjects and in patients with early retinitis pigmentosa.


The influence of pupil size in accommodative convergence: evaluation with pinhole contact lenses.


Residency Training Program in ophthalmology Manhattan Eye, Ear and Throat Hospital.


What is uveitis?

What is uveitis?


Placental and fetal RNA metabolism. I. In vivo labeling of the fetal and placental RNA in the 14-day pregnant rat.


Immunoassay of HPL by complement fixation.


Hormone secretion by the human ovaries.

Hormone secretion by the human ovaries.


Cardiovascular and ventilatory responses to exercise breathing 100 per cent oxygen.


Exercise training and resting oxygen consumption.


A comparison between the bicycle ergometer and the step-test for determining maximum oxygen intake on Kalahari bushmen.


Diagonal locomotion in de-afferentated toads.


Properties of action potentials from insect motor nerve fibres.


Body weight and the energetics of temperature regulation.


Regulation of cellular osmolarity and volume in Tetrahymena.


Cardiac ganglion of limulus: intracellular activity in the unipolar cells.


Extraneuronal potentials and potassium depolarization in cockroach giant axons.


The dimensions and sensitivities of semicircular canals.


Hepatic fatty acid synthesis and plasma free fatty acid levels in chicks subjected to short periods of food restriction and refeeding.


Effect of dietary molybdenum and sulfate upon urinary excretion of copper in sheep.


Effect of acylcarnitines on pyruvate metabolism in liver mitochondria from thiamin-deficient rats.


Availability of fluoride from fish protein concentrate and from sodium fluoride in man.


Effect of level of protein intake on urinary and fecal calcium and calcium retention of young adult males.


Dietary orotic acid and lipogenesis in the rat.


Meadow vole nutrition studies with semisynthetic diets.


Influence of a low casein diet on malate dehydrogenase activity of rat liver mitochondria and homogenate disrupted by various treatments.


Nickel toxicity in the young bovine.

Nickel toxicity in the young bovine.


Effect of ovarian steroids on maintenance of pregnancy in rats fed diets devoid of one essential amino acid.


Influence of exogenous ascorbic acid on calcium and phosphorus metabolism in the chick.


Aorta and other soft tissue calcification in the magnesium-deficient rat.


An agent promoting growth of rats fed amino acid diets (factor G).


An evaluation of screening tests for chronic lung disease.


Reversible hypercalcemia associated with prolonged thiazide administration to control hypertension.


Retinal detachment.

Retinal detachment.


The health of the coal miner--an expendable resource?


A practical look at the glaucomas.

A practical look at the glaucomas.


Medical examinations for coal miners.

Medical examinations for coal miners.


Coal dust standards and measurements.

Coal dust standards and measurements.


An international view of coal workers' pneumoconiosis.


An experience with "unemployable" workers.


The effect of ouabain and acetazolamide on transport of sodium and chloride from plasma to aqueous humor.


Inhibition of renal tubular transport of catecholamines by cocaine: an organic base mechanism.


A study of the mechanism responsible for the sensitivity of newborn rats to pregnanolone.


Effect of phenobarbital and SKF 525A pretreatment on diphenylhydantoin teratogenicity in mice.


Effects of phenobarbital on the plasma disappearance and biliary excretion of drugs in rats.


Effect of chronic intake of ethanol on pentobarbital metabolism.


The role of microsomal drug-metabolizing enzymes in the biliary excretion of 3,4-benzpyrene in the rat.


The metabolism of cyclamates in rats.

The metabolism of cyclamates in rats.


Daunomycin metabolism in rat tissue slices.


The effect of nicotinic acid on the caffeine-induced serum free fatty acid increase.


Radioimmunoassay for serum digitoxin concentration: methodology and clinical experience.


Effects of ketamine on contractile performance and excitability of isolated heart muscle.


Effects of CL 1848C, a new dissociative anesthetic, on the canine cardiovascular and respiratory systems.


Antagonism of the behavioral effects of morphine and methadone by narcotic antagonists in the pigeon.


Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake.


Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammations induced in rat and dog by carrageenan, sodium urate and ellagic acid.


Cesium effects on muscle membrane responses to quaternary ammonium ions.


The antipyretic effects of acetaminophen and sodium salicylate on endotoxin-induced fevers in cats.


On the mechanism of supersensitivity to norepinephrine in the denervated cat spleen.


Effect of intermittent nerve stimulation on norepinephrine synthesis and mobilization in the perfused cat spleen.


Specific subsensitivity of the rat atrium to cholinergic drugs.


The effect of intraneuronal inactivation on the transmembranal uptake of l- and d-norepinephrine.


On the possible existence of a new intraneuronal monoamine in the spinal cord of the rat.


Graphical and weighted regression analyses for the determination of agonist dissociation constants.


Blockade of the nicotine-induced norepinephrine release by cocaine, phenoxybenzamine and desipramine.


Early actions of cadmium in the rat and domestic fowl testis. 3. Subcellular location of injected 109 cadmium.


The lipid content of bovine spermatozoa during maturation and ageing.


Increased duration of pseudopregnancy associated with uterine distension in the rat.


Effect of an anti-androgen on the differentiation of the internal genital organs in dogs.


Influence of the genotype of males on pregnancy-block in inbred mice.


Influence of an IUD on the leucocytic content of the uterus and on the duration of pseudopregnancy in mice.


Testosterone propionate during gestation in the rabbit: effect on subsequent maternal behaviour.


Electrophoretic and gel filtration behaviour of boar seminal plasma proteins before and after removal of accessory sex glands.


The fate of unfertilized eggs in the rabbit.


The effect of hypervitaminosis A on opening of the vaginal membrane in the rat.


The chromosome complement of blastocysts from rabbits injected with various doses of HCG before ovulation.


Excretion of [6-14C]megestrol acetate (6 methyl-17 acetoxypregna-4,6 diene, 3,20 dione) released from subcutaneous silastic implants in women.


Pheromonal facilitation of ovulation in the immature mouse.


A 'posterior ring' in the spermatozoa of species of Muridae.


Sex proportion of domestic chicken at 16 hours of incubation.


Liquor amnii and foetal maturity.

Liquor amnii and foetal maturity.


Therapeutic abortions using prostaglandin E2.


Effect of prostaglandins on human uterus in pregnancy.


Effect of induced hypothermia and rewarming on renal hemodynamics in anesthetized dogs.


Dopamine concentrations in the caudate nucleus of the developing cat.


Some effects of an hallucinogenic drug (phencyclidine) on neurohumoral substances.


The effect of heat stress on body development in rats.


Effect of epinephrine and potassium chloride on contraction and energy intermediates in rabbit thoracic aorta strips.


Gallbladder disease in pima indians. Demonstration of high prevalence and early onset by cholecystography.


Glutamine in the phenylketonuric central nervous system.


Role of the emergency unit in a community hospital.


Circulatory assistance and emergency direct coronary-artery surgery for shock complicating acute myocardial infarction.


Medicare deadlock in Quebec.

Medicare deadlock in Quebec.


Case records of the Massachusetts General Hospital. Weekley clinicopathological exercises. Case 51-1970.


What's new in pku.

What's new in pku.


The future of medicine.

The future of medicine.


Screening programs.

Screening programs.


Granulomas in Hodgkin's disease.

Granulomas in Hodgkin's disease.


Insulin levels in hereditary ataxias.

Insulin levels in hereditary ataxias.


Elevated serum alkaline phosphatase levels in epilepsy during diphenylhydantoin therapy.


Myopia.

Myopia.


Unsolicited food additives.

Unsolicited food additives.


Implications of "unco-operative".

Implications of "unco-operative".


Physician liberation units system.

Physician liberation units system.


Smokers, help yourselves.

Smokers, help yourselves.


Smoking and flying.

Smoking and flying.


Forensic sciences.

Forensic sciences.


War in spite of good deeds.

War in spite of good deeds.


Gifts and medical care.

Gifts and medical care.


Hemoglobin O arab in four negro families and its interaction with hemoglobin S and hemoglobin C.


Stimulation of human-growth-hormone secretion by L-dopa.


Hyperchlorhydria and hyperhistaminemia in a patient with systemic mastocytosis.


Glucose homeostasis in viral hepatitis.

Glucose homeostasis in viral hepatitis.


Radar-induced failure of a demand pacemaker.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 52-1970.


Interactions of other hemoglobin variants with sickle-cell hemoglobin.


Measurement of fibrinogen degradation products.


Sedimentation rate: normal values.

Sedimentation rate: normal values.


Yersinia enterocolitica.

Yersinia enterocolitica.


No smallpox in Vietnam.

No smallpox in Vietnam.


Treatment of vitamin D intoxication.

Treatment of vitamin D intoxication.


No dictated practice.

No dictated practice.


Scalp tourniquet to lessen alopecia after vincristine.


The influence of back massage on autonomic functions.


Rehabilitation of the patient with a postsurgical lower extremity amputation.


Specificity of speed of exercise.

Specificity of speed of exercise.


Passive shoulder exercises.

Passive shoulder exercises.


Student selection for physical therapy education: a project in progress.


Let's reduce the understanding gap. 3. Experimental design: what and why?


Federal science: differences of opinion in the highest councils.


Computer-based chemical information services.


Specificity of antigen recognition by human lymphocytes in vitro. Delayed hypersensitivity reactions in vivo are exquisitely specific, in terms of both a lack of response after induction of tolerance and a response after sensitization. These studies in vitro demonstrate that this specificity, at least at the level of antigen recognition, is probably derived from different populations of cells, each responding to different antigens.


Postembryonic development of adult motor patterns in crickets: a neural analysis. Adult crickets have stereotyped patterns of motor output which are generated by the central nervous system, and which serve as a standard against which emerging nymphal patterns can be measured. The neural circuits generating these patterns are not functional at hatching. The pattern elements appear in an ordered sequence over the course of the last four molts. The circuits are completely functional before the final molt. Circuits which might be prematurely activated are suppressed in the nymph by descending inhibition from the brain.


APA information plan funded.

APA information plan funded.


Fluorocitrate inhibition of aconitase: relative configuration of inhibitory isomer by x-ray crystallography. The fluorocitrate isomer that is a strong inhibitor and inactivator of aconitase has been shown by x-ray crystallographic studies on the rubidium ammonium salt to have the configurations (1R : 2R) or (1S : 2S) 1-fluoro-2-hydroxy-1,2,3-propanetricarboxylic acid. A possible mechanism for the action of fluorocitrate is proposed which involves the 1R : 2R isomer suggested from biochemical data.


A thermophilic, acidophilic mycoplasma isolated from a coal refuse pile. A thermophilic, acidophilic procaryote lacking a cell wall has been isolated from a coal refuse pile which had undergone self-heating. Electron micrographs, chemical assays for hexosamine, and the inability of vancomycin to inhibit growth confirm the lack of a cell wall. The apparent ability of the organism to reproduce by budding and the low guanine plus cytosine content of its DNA indicate a relation to the mycoplasmas. The temperature optimum of the organism is 59 degrees C, and growth occurs over a range of 45 degrees to 62 degrees C. No growth occurs at 37 degrees C or at 65 degrees C. The optimum pH for growth is between 1 and 2, and growth occurs between pH 0.96 and 3.5 but does not occur at pH 0.35 and only poorly at pH 4.0. We propose to call this organism Thermoplasma acidophila. The existence of this organism extends considerably the range of habitats in which mycoplasma may occur.


Tongue cooling: a new reward for thirsty rodents. Thirsty rodents will persistently lick a stream of dry air pumped through a standard drinking tube. This air-licking is attenuated by experimental manipulations which reduce the evaporative cooling of the tongue and mouth produced by the airstream. This suggests that such cooling is itself an effective reward for thirstry rodents. We tested this hypothesis by presenting thirsty rodents with a piece of cold, dry metal. Different species spent from 9 to 40 percent of their session time licking the cold metal. When deprived of water hamsters reared from birth without access to drinking water licked cold metal in preference to metal maintained at room or body temperature. This preference was approximately equal to that of littermates reared normally. We conclude that tongue cooling is a primary reward for thirsty rodents.


Superior colliculus: single unit responses to stimulation of visual cortex in the cat. Electrical stimulation of area 18 of the cat visual cortex produces intense excitation of neurons in the superior colliculus. Excitation is followed by a period of decreased collicular responsiveness to light stimulation. These effects are seen in both directionally selective and nonselective units. The corticocollicular projection is retinotopically organized.


Focal lymphoid hyperplasia of gastric mucosa.


The relation of gonads and suprarenal glands to the rate and duration of normal and abnormal growth.


Behaviour of some enzymes from different structures studied on bioptic specimens of gastric mucosa in various pathological conditions.


Tropical sprue and malnutrition in West Bengal. 3. Biochemical characteristics of bile salts in the small intestine.


Tropical sprue and malnutrition in West Bengal. II. Fluid and electrolyte transport in the small intestine.


Tropical sprue and malnutrition in West Bengal. IV. Bile salt deconjugation in tropical sprue.


On the logarithmid transformation of intestinal bacterial counts.


Disturbance of the jejunal and colonic bacterial flora in immunoglobulin deficiencies.


Total fasting and sweat chloride secretion in obese men.


Effect of amino acid diets upon serum lipids in man.


Changes in plasma free amino acid concentrations in human subjects on hypocholesteremic diets.


Teaching the recommended dietary allowances.


Serum amino acid levels of northern Alaskan Eskimo infants and children.


Growth failure and congenital heart disease. Energy and nitrogen balance in infants.


Artificial challenge studies in rubella. Utilization of RA 27-3 rubella vaccines, rubella naturally acquired seropositives, and rubella susceptible children.


Replacement of cardiac valves in children.


Maternal filicide.

Maternal filicide.


Bilateral renal hypoplasia with oligomeganephronia. Oligomeganephronic renal hypoplasia.


Race as a variable in hearing screening.


Volvulus of the stomach.

Volvulus of the stomach.


Recurrent meningitis due to a congenital fistula through the stapes footplate.


Occult helminth infection with appearance of splenic and lung calcifications.


Occlusion of pulmonary veins, "mitral" insufficiency, and ventricular septal defect. Functional resemblance to ventricular aneurysm.


Pierre Robin syndrome in siblings.

Pierre Robin syndrome in siblings.


Congenital sensory neuropathy?

Congenital sensory neuropathy?


Ultrastructural aspects of normal human gingival epithelium.


Clioxanide, a new anthelmintic active against Fasciola hepatica and Haemonchus contortus in sheep.


Visual processing and the use of redundant information in tachistoscopic recognition.


Monitoring eye movements during paired-associate learning in a retroactive inhibition setting.


The effects of method of recall on performance in the dichotic listening task.


Development of mental abilities: an investigation of the "Differentiation Hypothesis".


Infections due to non-sporeforming anaerobic bacteria.


Carbenicillin in pulmonary infection complicating cystic fibrosis.


Adverse effects of antibacterial agents.


Kidney tuberculosis.

Kidney tuberculosis.


Localization of urinary tract infection.


Oxolinic acid therapy of recurrent urinary tract infections.


Minocycline in the treatment of urinary tract infections.


Cephalexin in the treatment of urinary tract infections.


The significance of the intestinal microflora.


A quantitative histologic analysis of selected tissues in growing mice.


A UV-labile morphogenetic substance in Volvox carteri.


Changes in rate of cellular proliferation during the differentiation of cartilage and muscle in the mesenchyme of the embryonic chick wing.


The in vitro cultivation and differentiation capacities of myogenic cell lines.


Changes in transfer RNA in developing brine shrimp.


Electron microscopic analysis of aggregation of embryonic cells: the structure and differentiation of aggregates of neural retina cells.


Vocal cord paralysis in Guillian-Barre syndrome.


Rhinosporidiosis.

Rhinosporidiosis.


Laryngeal cyst--a case report.

Laryngeal cyst--a case report.


Concerning nasal reflexes.

Concerning nasal reflexes.


A new disposable eye shield.

A new disposable eye shield.


The Vision Information Center.

The Vision Information Center.


Ophthalmology Program, Greater Baltimore Medical Center, Baltimore, Maryland.


The use of spermatogenic activity test for evaluation of therapy in young unfertile adults.


Clomiphene therapy in defective spermatogenesis.


Pergonal (menotropins): a summary of clinical experience in the induction of ovulation and pregnancy.


Uterine and oviduct fluid protein patterns in the rabbit before and after ovulation.


Electroencephalographic recording during progestation treatment.


Thiamphenicol excretion in subjects with renal insufficiency.


Data on the tissue concentration of antibiotics in man tissue concentrations of semi-synthetic penicillins in the fetus.


The uptake of Hg203, Cu64, Mn52, and Pb212 by the intestinal wall of the duodenal and ileal segment in vitro.


The protective influence of haptoglobin on hemoglobinuric kidney. II. Microscopic observations and clinical aspect.


Note describing a sensitive spectrophotometric method for determination of isoniazid.


Autonomic responses to threatening stimuli in relation to the repression-sensitization dimension.


Marital status and schizophrenia: a study of incidence and outcome.


Temporal stability of field dependence among hospitalized alcoholics.


Psychoendocrine studies of patients with spinal cord lesions.


Susceptibility to social influence and retention of opinion change in two types of delinquents.


Recalled dream content and the maintenance of body image.


New directions in psychotherapy research.


Autonomic conditioning in chronic schizophrenia.


Client-centered and behavior therapies: their peaceful coexistence: a case study.


Physiological concomitants of behavioral indexes in schizophrenia.


Social isolates and urbanites in perceptual isolation.


Role of verbal intelligence in the field approach of selected groups of psychotics.


Disordered language as related to autonomic responsivity and the process-reactive distinction.


Relative contributions of modeling, informational influences, and physical contact in extinction of phobic behavior.


Effects of sensory restriction on susceptibility to hypnosis: a hypothesis and more preliminary data.


Nonfluency, information, and word length.


Communication of intents among parents and their disturbed adolescent child.


Safety and efficacy of an inactivated tissue culture vaccine for feline panleukopenia.


Tilt aftereffects in central and peripheral vision.


Time judgment as a function of method, practice, and sex.


Evidence for an interruption theory of backward masking.


Effect of frustrative nonrelief upon shock-escape behavior in the double runway.


Short-term memory while shadowing: recall of visually and of aurally presented letters.


Semantic processing of unattended messages using dichotic listening.


Relative effects of display mode and input function on tracking performance.


Rated acceptability of mineral taste in water. 3. Contrast and position effects in quality scale ratings.


Dark intervals as stimulus events and their effect on visual masking and time-intensity reciprocity.


Direct psychophysical scaling of the odor intensity of undiluted N-aliphatic alcohols.


Response interference in an information processing task: sensory versus perceptual factors.


Effects of instructional set on pupillary responses during a short-term memory task.


Differential human eyelid conditioning as a function of the probability of reinforcement and CS similarity.


Effects of instructions on the skin resistance response.


A choice reaction time test of ideomotor theory.


Retrieval strategy in dichotic listening as a function of presentation rate and structure of material.


Reaction time as a function of perceptual bias, response bias, and stimulus discriminability.


The perception of rotary motion.

The perception of rotary motion.


Arousal effects in intentional recall and forgetting.


Effects of sight of the body and active locomotion in perceptual adaptation.


Auditory S-R compatibility: reaction time as a function of ear-hand correspondence and ear-response-location correspondence.


Motor response latency as an indicator of subliminal affective stimulation.


Inhibition of humor enjoyment: differential effects with traditional diagnostic categories.


Learning pairs of nonsense syllables and pleasant and unpleasant adjectives.


A hierarchal model for analyzing personality data.


The effect of retinal orientation on the recognition of novel and familiar shapes.


Cue effectiveness as a function of differential preadaptation.


Impression value, instructional set, and methods of stimulus presentation as factors influencing control subjects in verbal conditioning.


Epidemiological considerations of cancer of the gallbladder, bile ducts and salivary glands in the rubber industry.


Disorders of ocular motility.

Disorders of ocular motility.


Cataracts.

Cataracts.


Studies on pulmonary function and respiratory tract symptoms of workers in an iron ore mine where diesel trucks are used underground.


Finger tip injuries. Emergency and definitive care.


The UMWA looks at coal workers' pneumoconiosis.


The large general hospital, an industrial medical complex.


The influence of submaximal work on solvent uptake.


Sexual aspects of Rorschach administration.


A model for evaluating coal mine dust standards.


A note on achievement motivation and verbal fluency.


Rorschach content responses of East Indian psychiatric patients.


Psychological distance, future time perspective, and internal-external expectancy.


Physical activity and increases in M response.


Body image and defensiveness in an LSD-taking subculture.


Perceptual and cognitive processes in different states of consciousness: the waking state and hypnosis.


Intropunitiveness in suicidal adolescents.


Paranoia and power anxiety.

Paranoia and power anxiety.


Voice expression and rated extraversion.


Two cases of psychiatric symptoms following exposure to the Rorschach.


Lebanese and American aspects of personality: a cross-cultural comparison.


Authoritarianism in an "authoritarian" culture: the case of Afrikaans-speaking South Africa.


Group therapy interaction with and without the leader.


Creative abilities: a cross-cultural study.


Cross-modal congruity: visual and olfactory.


The role of internal inhibition in crime causation.


Substantive significance of the linguistic relativity hypothesis when using translations of written personality measures.


Signature size: a key to status awareness.


Interpersonal evaluation as a function of social attention.


Traffic accident research.

Traffic accident research.


Whither the society?

Whither the society?


Hereditary polyposis of the colon.

Hereditary polyposis of the colon.


The use of air splints as immediate prostheses after below-knee amputation for vascular insufficiency.


Clinical study of a new absorbable suture material--polyglycolic acid.


Oxygen therapy in acute respiratory failure.


An unusual salivary gland calculus.

An unusual salivary gland calculus.


Respiratory mechanisms and the metazoan fossil record.


Short term test for evaluating potential carcinogenic activity of tobacco condensates.


The biologist's dilemmas.

The biologist's dilemmas.


Fulfilment lags promise in biology.

Fulfilment lags promise in biology.


Evidence for extraterrestrial amino-acids and hydrocarbons in the Murchison meteorite.


Variability of interchain binding of immunoglobulins. Interchain bridges of mouse IgG2a and IgG2b.


Interchain bridges of human IgD.

Interchain bridges of human IgD.


Very lysine rich histone of echinoderms and molluscs.


Transmission of mouse neuroblastoma by a cell-free extract.


Mechanism of changes in brain norepinephrine metabolism after ovariectomy.


Prolactin and growth hormone production as influenced by catecholamines and agents that affect brain catecholamines.


Acute changes in blood and pituitary prolactin after a single injection of perphenazine.


Effect of lesion size in the ventromedial hypothalamus on growth hormone and insulin levels in weanling rats.


Distribution curves of 3H-testosterone and 3H-estradiol in neonatal female rats.


Mechanisms that determine the changes in pituitary MSH activity during pseudopregnancy induced by vaginal stimulation in the rat.


Genetic diagnosis in the newborn. A part of preventive medicine.


The photoisomerization of retinal.

The photoisomerization of retinal.


Absorption band shape and emission in rhodopsin.


Photoaddition of psoralen and of 4,5',8-trimethylpsoralen to DNA.


Photoproducts of bromouracil-labeled DNA and the structure of 5-bromodeoxyuridylyl-(3'-5')-thymidine photoproduct.


Mechanisms in the quantum yield of Cypridina bioluminescence.


Reliability of the flocculation test in the evaluation of the stability of freeze-dried diphtheria antitoxin by the accelerated degradation test.


Response to phytohaemagglutinin of lymphocytes from patients treated with anti-lymphocyte globulin.


An analysis of the multiplicity of the effects of anti-lymphocyte serum.


Researches on the isolation of human antilymphocyte globulin.


Studies on the local immunity of intestinal tract of chickens after oral administration of Newcastle disease virus.


Antibodies against lipase from staphylococci.


Antibodies against the isoenzymes of glutamic-oxalacetic-transaminase.


Investigations on the international pyrogen reference preparation.


Standardization of tests for toxicity for some materials used in tissue cultures laboratory.


Hormonal control of lymphatic tissue development in Snell-Bagg dwarf mice.


A new in vivo assay system for immunogenicity.


Properdin level changes as related to the appearance of metastases.


Artificial antigens and immunity to infectious disease.


Relationship between the molecular weight of tuberculoprotein and its biological potency.


Studies on the standardization of mycobacterial sensitins, using the hemaggregation-inhibition technique.


Potency control of tetanus and diphtheria toxoids, adsorbed, produced in Bulgaria.


The differences in immunizing capacity between various tetanus toxoids in active-passive immunization with human antitoxin.


Adjuvants and delayed-type hypersensitivity due to infection.


Effectiveness of mumps virus given alone or in combination with live vaccines against measles and rubella.


The action of an antitrachoma vaccine on mouse experimental pulmonary infection.


The immunity to vaccina virus of Japanese people of different age groups: serum antibody titre and local skin reaction at the site of vaccination.


Proteolytic digestion and chemical cleavage of human IgA.


Protein-polyacrylamide gel, an immunosorbent of high capacity.


Observations on the preparation and testing of stable and unstable immune serum globulin preparations.


Intraventricular infusion of ethanol in dogs. Effect on voluntary alcohol intake.


The alcoholic symptom and its therapeutic relevance.


Abstinence and time perception of alcoholics.


Serum enzyme, corticosterone and tissue changes in rats following a single oral dose of ethanol.


Effects of alcohol on its utility for alcoholics and nonalcoholics.


Family therapy with the families of recovering alcoholics.


Some epidemiological data on alcoholism in Maryland: based on admissions to psychiatric facilities.


Cerebral dysfunction in alcoholics. A psychometric investigation.


Formation of complexes of thiol and amino compounds as studied by amperometric titration and infrared spectrometry.


A patient with hereditary galactokinase deficiency.


The content of lipofuscin in liver bopsies from patients operated for gallstones.


The relationship of cartilage canals to the initial osteogenesis of secondary centers of ossification.


Recent advances in immunization against viral diseases.


Vascular and respiratory emergencises.

Vascular and respiratory emergencises.


Competition between leucine and phenylalanine and its relation to p-fluorophenylalanine resistant mutations in Aspergillus nidulans.


The distribution of NADH oxidase in the membrane system of Rhodospirillum rubrum.


Distribution and placental transfer of 131-I streptokinase.


Nuclear magnetic resonance studies of hemoglobiss. V. The heme proton spectra of human deoxyhemoglobins A, F, Zurich, and Chesapeake.


Disaggregation of giant "DNA-like RNA" of yeast by denaturation in the presence of formaldehyde.


Possible control of intracellular calcium metabolism by [H+]: sarcoplasmic reticulum of skeletal and cardiac muscle.


Catalytic subunit of firefly luciferase.


Kinetic studies on the mechanism of insect acetylcholinesterase.


Purification and properties of a trypsin-like enzyme from the starfish Evasterias trochelii.


Lipid metabolism in bilharzial cirrhosis.


Optical properties of specific complexes between complementary oligoribonucleotides.


Fluorescence studies of Aplysia and sperm whale apomyoglobins.


Biochemical similarity of papain-solubilized H-2d alloantigens from tumor cells and from normal cells.


Fate of phospholipids in liposomal model membranes damaged by antibody and complement.


Arteriosclerosis in rabbit aorta induced by noradrenaline. The importance of the duration of the noradrenaline action.


Further studies on the fatty acid specificity of rat liver sterol-ester hydrolase.


Interaction of a repotter molecule with chromatin. Evidence suggesting that the proteins of chromatin do not occupy the minor groove of deoxyribonucleic acid.


Fatty acids of Monnina emarginata seed oil.


Fatty acid biosynthesis. VI. Specificity for termination of fatty acid biosynthesis by fatty acid synthetase from lactating-rabbit mammary gland.


A rapid immunological assay of endonuclease activity.


Grounding of patient monitoring systems.


Annular pancreas and jaundice.

Annular pancreas and jaundice.


Accuracy of screening methods for breast disease.


Pressure studies of the choledochoduodenal junction in man and the pig.


The effect of retransfusion and beta-adrenergic blockade on muscle blood-flow and lactic acidosis in haemorrhagic shock in dogs.


Regional blood flow and oxygenation in haemorrhagic shock.


Transplantation of joint surfaces by cartilage grafts.


Gastric acid secretion and duodenal ulcer in Crohn's disease.


Low-dose, pentagastrin infusion studies.


Recovery of vagal nerve function after vagotomy.


An analysis of spontaneous acid secretion and its relation to the insulin response in normal and duodenal ulcer subjects: new criteria for insulin test.


The effect of Arvin on blood-coagulation and patency of venovenous shunts in the dog.


Technical problems in direct left gastric vein diversion.


Haemodynamic effects of portacaval transposition in severe experimental cirrhosis.


The effect of hexamethonium and atropine on gastric emptying of hyperosmolar glucose solution.


Preliminary study in developing an operation for control of gastro-oesophageal reflux.


Bile reflux in active and healed gastric ulcer.


The magnitude of the intestinal phase of gastric-acid secretion.


The spontaneous motility and the action of cholecystokin pancreozymin, secretin, and agastrin on the canine extrahepatic biliary tract in vitro.


Evaluation of preoperative drill biopsy in the diagnosis of mammary cancer.


The myoelectrical activity of the isolated perfused canine stomach nand duodenum.


The effect of secretion on the myoelectric activity of the duodenum and bowel.


Urinary steroid excretion in patients with advanced breast cancer.


The role of scintigraphy in the assessment of response to therapy of skeletal metastases from mammary cancer.


The soleal sinuses: origin of deep-vein thrombosis.


Fibrinogen-fibrin degradation products in venous thromboembolic disease.


Cahanges in fibrinolytic activity in response to surgical trauma.


A comparative study of strain-gauge plethysmography and Doppler ultrasound in the assessment of occlusive arterial disease of the lower extremities.


The measurements of resting metabolic expenditure in surgical patients by means of a diaferometer.


Measurement of acute changes in extracellular fluid volume with radiobromide.


The postoperative metabolism of fibrinogen: studies with 125I-labelled fibrinogen.


Jejunal permeability to sodium, potassium, and water immediately after surgery.


The effect of operation on the intestinal handling of water, sodium, and potassium.


The effect of intraperitoneal Malayan pit-viper venom on adhesion formation and peritoneal healing.


Simultaneous pressure-flow measurement in intermittent claudication.


The effect of temperature on the metabolic activity and growth rate of the VX2 carcinoma in rabbits.


A study of micturition pressure and urine flow rate in thirty-eight incontinent patients.


Renal inactivation of gastrin.

Renal inactivation of gastrin.


Insulin and the intestinal absorption of glucose.


A case of polycystic adventitial disease of the left external iliac and femoral artery.


Concurrent hyperthyroidism and hyperparathyroidism.


An unusual gall-stone.

An unusual gall-stone.


Bilobed gall-bladder.

Bilobed gall-bladder.


Undiagnosed abdominal pain.

Undiagnosed abdominal pain.


L-dopa treatment failure: explanation and correction.


Glucose tolerance sum criteria in a non-patient control population.


The three-hour glucose tolerance sum in normal, equivocal and abnormal tests.


Induction of labour.

Induction of labour.


The peripheral nervous system of adult Nigerians without overt neurological disease--a community sample study.


Bupivacaine--clinical experience on 50 Nigerian cases.


Pyogenic meningitis in Lagos.

Pyogenic meningitis in Lagos.


Parenteral chloroquine in children.

Parenteral chloroquine in children.


Hospitals may assume role of information centres.


"When is a hospital liable for negligence to its patients"?


How to mobilize practical political support.


Waste disposal--a growing international problem.


Space for hospital stores.

Space for hospital stores.


A quiet explosion. Winnipeg general's computer story.


Medico-sociological information exchange program--a proposal.


Throwing it away.

Throwing it away.


Purchasing and the Task Force Reports.

Purchasing and the Task Force Reports.


The value checklist.

The value checklist.


A synthetic approach to camptothecin.

A synthetic approach to camptothecin.


Right bundle-branch block and left anterior fascicular block (left anterior hemiblock) following tricuspid valve replacement.


The effect of antigen given intravenously on specific antigen-sensitive lymphocytes of peripheral blood in man.


Jaundice and splenomegaly.

Jaundice and splenomegaly.


Meiotic nondisjunction in mice and mouse hybrids.


Induction of ovulation with human menopausal gonadotropin: the effect of prior treatment with estrogen.


Quantitative genetics of fertility. II. Lifetime egg production of Drosophila melanogaster--experimental.


Age-linked modification of the effect of estrogen on joints and cortical bone of female mice.


Aging of collagen in tissue culture.

Aging of collagen in tissue culture.


Vulnerability to risk and awareness of dual choice of health insurance plan.


Significance levels in multiple comparison tests.


Forecasting by a modified exponential smoothing method.


Waiting time as an index of quality of nursing care.


A community approach to the delivery of health services.


Public utility regulation.

Public utility regulation.


Computerized information system.

Computerized information system.


Maintenance problems in small hospitals.


Epilogue and a new beginning.

Epilogue and a new beginning.


Adolescence and social change.

Adolescence and social change.


Certain cultural and familial factors contributing to adolescent alienation.


Alienation: an essential process of the psychology of adolescence.


"Youth unrest": reflections of a psychoanalyst.


Alienation of youth as reflected in the Hippie movement.


Behavior deviations in mentally retarded children.


Aleenation of present-day adolescents.

Aleenation of present-day adolescents.


Psychophysiologic and conversion reactions in children. Selective incidence in verbal and nonverbal families.


The selective toxicity of new N-phosphorothioyl-carbamate esters.


Residential treatment of children. A survey of institutional characteristics.


Transitional objects and the process of individuation: a study in three different social groups.


The role of geographic mobility in some adjustment problems of children and families.


Fleeting phobias.

Fleeting phobias.


Special considerations in the operation of a Head Start program by a community child guidance clinic.


The hypoglycemic agents--their interactions.


Acute effects of cold on blood levels of growth hormone, cortisol, and thyrotropin in man.


An assessment of an automated fluorimetric blood phenylalanine technique for phenylketonuria screening and for accurate estimations. An assessment of the automated fluorimetric technique for the estimation of phenylalanine, using blood collected and stored on filter paper, indicated that its accuracy and precision compared favourably with those of other methods, including the bacteriological inhibition assay. The method appeared to offer advantages, both in the detection of phenylketonuria and for the more accurate determinations required in the further investigation and control of known cases.


Electrophoretic analysis of cell proteins of T-strain mycoplasmas isolated from man. Electrophoretic patterns of the cell proteins of 12 T-strain mycoplasmas isolated from man showed a remarkable similarity. This finding suggests that these strains are genetically closely related and supports their classification in a single species.


From the subject's point of view, when is behavior private and when is it public problems of inference.


Effects of cognitive style and teaching method on categories of achievement.


The effect of anticoagulants on thromboplastin generation.


L-Dopa therapy in Parkinson's disease (a year's experience with 20 patients).


Congenital nephrotic syndrome: case with electron microscopic and family studies.


Indications for the use of anticoagulants in stroke syndromes.


Careful food handling: a must.

Careful food handling: a must.


Possible agent in the transmission of Crohn's disease and its similarity to sarcoidosis.


Immunization levels need constant attention.


Cervical lymph node biopsies.

Cervical lymph node biopsies.


A Hoosier success.

A Hoosier success.


Credit and collection policies for the medical office.


Congenital cup-shaped deformity of the ear.


Extirpation experiments on embryonic rudiments of the carapace of Chelydra serpentina.


Comparison of effects of 1,8-dihydroxyanthraquinone and 1,5-dihydroxyanthraquinone on different segments of rabbit gastrointestinal tract.


Ontogenesis of drug-induced tremor in the rat.


Metabolism of optically active barbiturates. II. S (-)--pentobarbital.


Investigation of canine tissue reaction to TFE-fluorocarbon resin, to high-density polyethylene, and to vitallium.


Influence of intestinal microorganisms on the metabolism of bile acids in mice.


Monoassociation with bacteria in the intestines of germfree mice.


Irradiation cell for oxygen absorption measurements.


The effects of p-chlorophenylalanine on behavior. 3. Facilitation of brightness discrimination in satiated rasts.


The interaction of glucagon with theophylline, PGE1, isoproeerenol, ouabain, and CaC1 on the dog isolated papillary muscle.


A career in art as applied to medicine--an editorial.


Latex molds and casts.

Latex molds and casts.


A.M.I. Presidential Address, 1968.

A.M.I. Presidential Address, 1968.


The elimination of manual transfer.

The elimination of manual transfer.


Pen and ink illustration.

Pen and ink illustration.


Preparation of copy for the graphic arts.


Teamwork of medical illustrator and physician.


Pen approaches.

Pen approaches.


Preparing eye illustrations as observed through the slit lamp.


Medical art as a business.

Medical art as a business.


The Oslo assembly of the World Medical Association.


Electrical pacing of the heart.

Electrical pacing of the heart.


A hazard of nephrectomy.

A hazard of nephrectomy.


Compulsory wearing of safety belts.

Compulsory wearing of safety belts.


Neurological complications of influenza A2-Hong Kong-68 virus.


The most common fee.

The most common fee.


Forceps--a forgotten procedure?

Forceps--a forgotten procedure?


Referral to specialists.

Referral to specialists.


Tine test conversion in Vietnam.

Tine test conversion in Vietnam.


Nearly 100 pills per day.

Nearly 100 pills per day.


Cyclamates farce not appreciated.

Cyclamates farce not appreciated.


Research in muscular dystrophy.

Research in muscular dystrophy.


X-rays from domestic colour television receivers in Britain.


Primary structure of alpha-lytic protease: a bacterial homologue of the pancreatic serine proteases.


Gene conversion in Drosophila: non-reciprocal events at the maroon-like cistron.


Rapid detection of penicillin sensitivity in Staphylococcus aureus.


Gerbich blood group system: a useful genetic marker in certain Melanesians of Papua and New Guinea.


Lymphocyte stimulation by bovine beta-lactoglobin.


Effects of glutaraldehyde on the protein loss and photochemical properties of kale chloroplasts: preliminary studies on food conversion.


Dual innervation of the pineal of the fowl, Gallus domesticus.


Quantitative tissue of human malnutrition using scalp hair roots.


Prevention of hypercholesterolaemia in thyroidectomized rats by growth hormone.


Long-term isolation in rats reduces morphine response.


The work of a 'nurse practitioner'. Experience of two years in a West Midlands group practice.


Piezoelectric effect and growth control in bone.


Development of the brain depends on the visual environment.


Drug-induced release of 3H-norepinephrine and 3H-serotonin from brain slices.


Nursing care of babies with cleft lip and palate. 3. Trisomy of the 13-15 chromosome group (Patau's syndrome--trisomy D1).


Flying phobia: phobia: phenomenological study.


Ulceration of the colon in guinea-pigs fed carrageenin.


The genetic activity of mitochondria and chloroplasts.


Automatic analysis of blood cells.

Automatic analysis of blood cells.


Experiments in intergroup discrimination.


Scanning electron microscopy of the organ of Corti. With the scanning electron microscope we have examined normal cochlear sensory epithelium of the guinea pig and cat and that damaged by noise. The studies demonstrate how the regular surface architecture of the organ of Corti is altered after exposure to noise. The changes include loss of sensory hairs, formation of giant hairs, and complete degeneration of circumscribed areas of the organ of Corti. Our method greatly reduces the artifacts.


Hydrolysis rates of long chain triglycerides: "in vivo" study.


Pharmacological differentiation of allergic and classically conditioned asthma in the guinea pig. A whole-body plethysmographic technique was developed and then used to detect experimentally induced asthma in guinea pigs and to assess pharmacological treatments of allergic and classically conditioned attacks. Inhalation of a beta adrenergic compound (isoproterenol) controlled both forms of attack. Atropine and methscopolamine, parasympathetic blocking agents, prevented conditional but not allergic attacks; diphenhydramine, an antihistamine, prevented allergic attacks; and methysergide, which blocks serotonin (which is believed to trigger human asthma), prevented neither. The guinea pig's allergic reaction is probably the result of a bronchospasm induced by histamine released in tissue of the airway by a local combination of allergen and antibody. The conditional attack is believed to be a constriction of the airway mediated by parasympathetic fibers of central origin.


Extraction of an inhibitor of DNA synthesis from human peripheral blood lymphocytes and bovine spleen.


Effects of adriamycin on human lymphocytes stimulated with PHA "in vitro".


Arsenic and water pollution hazard.

Arsenic and water pollution hazard.


RNA hybridization: competition between species.


Regulation of temperature during surgical anesthesia in the adult patient.


Lymphocytic reaction around primary and metastatic melanomas.


Spontaneous rupture of the esophagus: a review with reports of six cases.


Alteration in protein and carbohydrate metabolism of chick embryos infected with Staphylococcus aureus.


Alterations in lipids of chick embryos infected with Staphylococcus aureus.


Secundum auxiliari.

Secundum auxiliari.


Travelogue 1969.

Travelogue 1969.


Microscopic observations on abdominal sympathetic paraganglia.


Social status, ethnic status, and urban mortality: an ecological analysis.


Electrophoretic comparison of ceruloplasmin types in ten primate species.


Use of the aortic pulse as an index of myocardial contractile force.


Strongyloidiasis causing fatal peritonitis.


Death of chickens in anti-malaria D.D.T. spraying.


Commercial airline pilot and his ability to remain alert.


Helium-oxygen saturation diving. I. Hematologic, lactic acid dehydrogenase and carbon monoxide-carboxyhemoglobin studies.


Lower body negative pressure as an assay technique for orthostatic tolerance. 3. A comparison of the individual response to incremental leg negative pressure vs. incremental lower body negative pressure.


Synergistic oxygen-inert gas interactions in laboratory rats in a hyperbaric environment.


Symptomatology of decompression sickness in male sprague-dawley rats.


Effect of metal ions on oxygen toxicity.


Doppler indices of decompression sickness: their evaluation and use.


Dynamics analysis for time of useful function (TUF) predictions in toxic combustive environments.


Electrochemical aircrew oxygen systems.

Electrochemical aircrew oxygen systems.


Effect of immersion at different water temperatures on graded exercise performance in man.


Effect of time zone changes on the sleep patterns of BOACB. 707 crews on world-wide schedules.


Life on orbital stations.

Life on orbital stations.


Xanthine oxidase for calibration of the oxygen electrode apparatus.


Radiochemical assay of long-chain fatty acids using 63Ni as tracer.


Determination of degree of polymerization of N-acetyl chitooligoses by chromatographic methods.


A simple protein meter.

A simple protein meter.


Method for determination of plastoquinone A and plastoquinol A levels in spinach chloroplasts.


Determination of tryptophan in feeds.

Determination of tryptophan in feeds.


Degradation of acetate-14C: modification of Roseman's benzimidazole procedure.


Fluorescent substances in protein hydrolyzates. I. Acid "hydrolyzates" of individual amino acids.


Spectrophotometric determination of phosphate esters in the presence and absence of orthophosphate.


Temperatures in polyacrylamide disc electrophoresis: influence on LDH isoenzymes.


Spectrophotometric determination of copper with N,N,N',N'-tetraethylthiuram disulfide and an application of this method for studies on subcellular distribution of copper in rat brain.


Series disc electrophoresis: its application to enzyme research.


On the absorbancy of reduced methyl viologen.


On the specificity of labeling in tritiated folic acid.


Interferences by sulfhydryl, disulfide reagents and potassium ions on protein determination by Lowry's method.


Determination of lipid phosphorus in the nanomolar range.


Preparation of 32P-labeled inositol hexaphosphate.


Automated analysis of polysaccharide and protein in cartilage.


Fluorescein-hemoglobin as a substrate for cathepsin D and other proteases.


Ammonia determination: reagent modification and interfering compounds.


Comparative studies of liquid scintillation counting of aqueous 14C samples.


Studies on the reaction of proteins and peptides with methyl isothiocyanate and identification of the methylthiohydantoins by gas-liquid chromatography.


Nucleotide analysis of deoxyribonucleic acid containing deoxybromouridylic acid.


Device for slicing polyacrylamide gels.

Device for slicing polyacrylamide gels.


Enzymic assay for galactosyl transferase activity of lactose synthetase and alpha-lactalbumin in purified and crude systems.


Histochemical abnormalities of skeletal muscle in acutely psychotic patients. II.


Agoraphobic syndrome (phobic anxiety state).


Decision-making and role shifts as they affect the consultation interface.


Supervision of the resident's initial interview.


Hostility factors and clinical improvement in depressed patients.


Female criminals: their personal, familial, and social backgrounds. The relation of these to the diagnoses of sociopathy and hysteria.


Increased blood serotonin and platelets in early infantile autism.


Reaction of the substrate analog bromopyruvate with two active-site conformers of 2-keto-3-deoxy-6 phosphogluconic aldolase.


Nitrocytochrome c. I. Structure and enzymic properties.


Thiolysis of dinitrophenylimidazoles and its use during synthesis of histidine peptides.


Effects of guanidine derivatives and oligomycin on swelling of rat liver mitochondria.


Histochemical study of the metabolism of the ketone bodies in the nervous system. I. Histochemical characteristics of the activity of the D(-)-beta-hydroxybutyric dehydrogenase.


Preplacement health screening by nurses in industry.


Are we really meeting our patients' needs?


Continuing to care--even in the air.

Continuing to care--even in the air.


The autistic child.

The autistic child.


Winter isn't so very far away.

Winter isn't so very far away.


Blockade of copulation-induced ovulation in the rat by anterior hypothalmic deafferentation.


Effects of hydrocortisone acetate and estradiol in normal and adrenalectomized salt deficient rabbits.


In vitro stimulation of leucine incorporation into muscle and cartilage protein by a serum fraction with sulfation factor activity: differentiation of effects from those of growth hormone and insulin.


The effects of immunization with human placental lactogen on reproduction in female rats.


Alterations in intrathyroidal iodine metabolism in response to chronic iodide administration.


Maintenance of ovine corpora lutea in the absence of ovarian follicles.


A bioassay for thyroxine based on rat kidney transamidinase activities.


Comparative effects of phosphate and thyrocalcitonin on skeletal turnover.


Prolactin induction of enzymes controlling luteal cholesterol ester turnover.


Effect of ultimobranchialectomy on the laying hen.


Influence of gonadectomy and replacement with estradiol or testosterone on formation of 5 alpha-reduced metabolites of corticosterone by the adrenal gland of the rat.


Role of protein synthesis in the utilization of administered iodide by thyroid glands in rats.


Effect of hypophysectomy on immobilization-induced elevation of tyrosine hydroxylase and phenylethanolamine-N-methyl transferase in the rat adrenal.


Effect of hypoglycemia on plasma renin activity in dogs.


Bioassay of glucagon using the isolated perfused rat liver.


Effect of thyroparathyroidectomy and parathyroid hormone on urinary excretion of calcium and phosphate in the golden hamster.


Early stimulation of mitochondrial protein synthesis in livers from triiodothyronine-injected mice.


Effect of orchidectomy on the intestinal secretion of dogs.


The effect of L-epinephrine and triamcinolone on the incorporation of acetate-2-14C and 32Pi into phospholipids and neutral lipids in liver slices from adrenalectomized rats, in vitro.


Effect of urea and guanidine hydrochloride on the biological activity of ovine follicle stimulating hormone (FSH).


Glycogen and water responses to estrogen in the hamster reproductive tract.


Influence of growth hormone, fasting and alloxan diabetes on pituitary, tibia and adrenal glycogen levels in the rat.


Effects of starvation on adrenal cortical function in the rabbit.


Effects of corticosteroids on the circulation in shock: experimental and clinical results.


Role of a myocardial depressant factor in the pathogenesis of circulatory shock.


Control of ovulation. Introductory remarks.


Genetic aspects of human HL-A transplantation antigens.


Effect of drugs on animals exposed to chronic environmental stress.


Measuring the effectiveness of mental hospitals.


Influence of reduced pressure on drug administration.


Community mental health on the college campus.


A small-group approach on State Hospital wards.


Low-cost individualized treatment in a day center.


Establishing a therapeutic community in a municipal hospital.


Educational considerations in discharging juveniles.


Outpatient management of passive-dependent women.


Facial paralysis complicating herpes zoster.


An alcoholism program tailored to community needs.


Calcifying  epithelioma. (Report of a case).


Role of genetics in dermatology.

Role of genetics in dermatology.


Studies on the relationship of protein binding and gel-affinity of antibiotics including penicillins.


Semisynthetic coumermycins. VI. Preparation and properties of 3-(3-aryl- and 3-aralkyl-4-hydroxybenzamido)-4-hydroxy-8-methyl-7-[3-O-(5-methyl-2-pyrrolylcarbonyl)noviosyloxy]coumarins.


Janiemycin, a new peptide antibiotic.

Janiemycin, a new peptide antibiotic.


Aranoflavin, a new antibiotic.

Aranoflavin, a new antibiotic.


A new peptide antibiotic complex S-520. IV. Isolation of three new amino acids from the hydrolysate.


Chemistry of leucomycin. IX. Identification of leucomycin A3 with josamycin.


Mechanism of cyclopropane ring cleavage in cyclopropanecarboxylic acid.


Analysis of equilibrium data from proton magnetic relaxation rates of water for manganese-nucleotide-kinase ternary complexes.


Enzyme variants in thermal acclimation. Trout liver citrate synthases.


The intracellular hemoglobins of a polychaete. Some properties of the hemoglobins of Glycera dibranchiata.


Base-catalyzed exchange of the iron and sulfide of clostridial ferredoxin.


The all-or-none mode of the reconstitution and the reactions of a,a'-bipyridyl and mercurials with clostridial ferredoxin.


Further characterization of apolipoproteins from the human plasma very low density lipoproteins.


The effect of pH on the reactions of oxygen and carbon monoxide with the hemoglobin of the carp, Cyprinus carpio.


Turnover of several glycolytic enzymes in rat liver.


Properties of some glycosyltransferases in embryonic chicken brain.


Hormonal regulation of rapidly labeled ribonucleic acid in mammary cells in vitro.


The dynamics of synthesis and degradation of polyamines in normal and regenerating rat liver and brain.


The enzymatic conversion of uracil 5-carboxylic acid to uracil and carbon dioxide.


Observations of the infectivity of RNA from Antheraea virus (AV).


Metabolic changes in diseased insects. 3. Nucleic acid metabolism in Lepidoptera infected by densonucleosis and Tipula iridescent viruses.


Replication of a nuclear polyhedrosis virus in an established insect cell line.


Possible defensive mechanism of hymenolepis diminuta cysticercoids to hemocytes of the beetle tribolium confusum.


Sodium and potassium fluxes in Philosamia ricini during Bacillus thuringiensis protein crystal intoxication.


Partial-body irradiation of larvae of tenebrio molitor.


Premature mortality--what is the answer?


Case report: multiloculated lymphangiomatous cyst of the ileum.


Blood gas, fluid and osmotic monitoring in the coronary-pulmonary care unit.


Locality rule.

Locality rule.


Right of action for injury to, or death of a woman who consented to abortion.


Statute of limitations against physicians and surgeons for malpractice.


Economical long-distance telephoned electrocardiographs.


Family planning--a health priority.

Family planning--a health priority.


The unresting specialty. tThe 1970 AANS presidential address.


The changing role of the institution in health care. The 1970 Harvey Cushing oration.


Extradural and subdural hematomas. Changing patterns and requirements of treatment in Australia.


The fate of retained intracerebral shotgun pellets. An experimental study.


The spinal manometric examination (Queckenstedt's test). The effects of certain factors as seen in a hydraulic model.


Spinal cord participation in the Cushing reflex in the dog.


Creation and operation of a bone bank.

Creation and operation of a bone bank.


External carotid-transverse sinus fistula. Case report.


Attempted infanticide by insertion of sewing needles through fontanels. Report of two cases.


Study on peripheral circulation using 131-I-macroaggregated serum albumin.


Differential diagnosis of organic and functional impotence by the use of 131-I-human serum albumin.


Arteriographic studies of splenic and hepatic arteries in portal hypertension.


Evaluation of surgical treatment of chronic pancreatitis.


Abnormally high levels of lactate and pyruvate in cerebrospinal fluid of hyperalaninemia with hyperpyruvicemia.


Culture conditions necessary to sustain the serial culture of lung cells of newborn hamster in albumin fortified medium.


Action of animal albumin preparations on the growth of lung cells of newborn hamster.


Immunoreactive luteinizing hormone in acetone precipitates and kaolin extracts of human urine.


Late recurrence in carcinoma of the cervix.


Intraepithelial carcinoma of the vulva.

Intraepithelial carcinoma of the vulva.


Familial male hermaphroditism with ambiguous external genitalia.


Antiurinary follicle-stimulating hormone serum in radioimmunoassay.


Endometrial leukocytes in patients using intrauterine contraceptive devices.


Blood serum amino acids of nonpregnant women who have given birth to children with gross developmental malformations.


Ultrastructural changes in mouse myometrium during pregnancy.


Studies on beta thalassemia trait in pregnancy.


Thyroid hormone relationships between maternal and fetal circulations in human pregnancy at term: a study in patients with normal and abnormal thyroid function.


Combined method for evaluating fetal well-being by plasma estriol measurements and ultrasonography.


Thyroid function studies following the Schiller test (using Lugol's solution).


Spontaneous abortion and human pesticide residues of DDT and DDE.


The continuing search for meaning.

The continuing search for meaning.


Sex ratio in human embryos obtained from induced abortion: histological examination of the gonad in 1,452 cases. In this histological analysis of 1452 human embryonal gonads on a large scale, embryos were obtained from mothers whose pregnancies were interrupted by curretage mainly for social reasons.  The ratio of male to female embryos was fairly constant at and after Streeter's Horizon 20 at values of about 130.  At Horizons 18 and 19 a remarkably high sex ratio was obtained: 385 and 212, respectively.  From these data it may be conceivable that the earlier the gestational stage, the higher the sex ratio of conceptuses, i.e., contrary to theoretical calculation, the primary sex ratio may not be 100, but may be even higher than the secondary  ratio of 106 males to 100 females at birth.


Bilateral and unilateral ECT: follow-up study and critique.


Revolutionists among the Chicago demonstrators.


Adjustment of mentally retarded patients in a hospital for the mentally ill.


Frequency of diagnoses of schizophrenia versus affective disorders from 1944 to 1968.


The serious suicide attempt: epidemiological and follow-up study of 886 patients.


Dimensions of institutional racism in psychiatry.


Problems of black psychiatric residents in white training institutes.


Beware of whites bearing gifts.

Beware of whites bearing gifts.


Reflections on racism.

Reflections on racism.


Research and careers for blacks.

Research and careers for blacks.


Adverse marijuana reactions: a critical examination of the literature with selected case material.


Alienation-reduction in brief group therapy.


Effect of lithium carbonate, placebo, and thioridazine on hyperactive children.


Criminal recidivism and psychiatric illness.


More on psychiatric practices in the Soviet Union.


Manic-depressive illness and schizophrenia.


Guidelines for psychoanalysts.

Guidelines for psychoanalysts.


Coordination: a needed factor in the certification process.


Death and confidentiality.

Death and confidentiality.


Psychiatry made easy.

Psychiatry made easy.


Microbiological leaching of a zinc sulfide concentrate.


Dialysis fermentation. I. Enhanced production of salicylic acid from naphthalene by Pseudomonas fluorescens.


An autoclavable version of the Mackereth oxygen probe.


A defined medium for the production of lysergic acid alkaloids by Claviceps paspali.


The effect of small amounts of sodium hypochlorite on the growth of Earl's "L" cells in suspension growth.


The clinical value of frequency analysis of the first heart sound in myocardial infarction.


The role of left atrial transport in aortic and mitral stenosis.


Distribution of pulmonary blood flow after myocardial ischemia and infarction.


Anomalous left coronary artery from pulmonary artery: report of 11 cases; review of indications for and results of surgery.


The effect of ethanol on continuous culture stability.


Catheterization of the pulmonary artery in transposition of the great arteries: a simple method.


Anomalies associated with coarctation of aorta: particular reference to infancy.


Eradication of rheumatic fever: an unfulfilled hope.


Total excitation of the isolated human heart.


The international cooperative study on epidemiology.


Interpretation of isopotential surface maps in patients with Ostium Primum and Secundum atrial defects.


Ventriculo-atrial conduction in man.

Ventriculo-atrial conduction in man.


Wenckebach and Mobitz type II A-V block due to block within the His bundle and bundle branches.


Observations on atrioventricular conduction in patients with bilateral bundle-branch block.


The pattern of onset and spontaneous cessation of atrial fibrillation in man.


Report of Inter-Society Commission for Heart Disease Resources. I. Prevention of Cardiovascular Disease. Prevention of pulmonary heart disease.


Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock).


Report of Inter-Society Commission for Heart Disease Resources. I. Prevention of Cardiovascular Disease. Prevention and early detection of thromboembolic disease.


Serial cardiac catheterizations and exercise hemodynamics after correction of tetralogy of Fallot: average follow-up 13 months and 7 years after operation.


Electrocardiographic changes during lithium treatment.


Validation of the MacAndrew-Rosen drug therapy scale.


Further investigation of factors affecting outcome in a doctor's choice treatment setting.


Electroencephalographic findings in affective psychoses. A comparative clinical and electrophysiological study.


Suicide: seasonal patterns and related variables.


The upward mobile Negro family in therapy.


Hospital experience with fluphenazine enanthate.


Detection of a hypocalcemic factor in the urine of hypocalcemic rats.


Feedback regulation of TSH secretion in rats with hypothalamic lesions.


The ultimobranchial body in rana pipiens. XI. Response to increased dietary calcium--evidence of possible physiological function.


Stimulation of proteolysis in the mouse thyroid gland by thyrotropin and the long-acting thyroid stimulator: comparison of intact lobe and homogenate.


Penetration of exogenous testosterone, pregnenolone, progesterone and cholesterol into the seminiferous tubules of the rat.


Selective activation by short chain alcohols of glucagon responsive adenyl cyclase in liver.


Thyroglobulin in fractions of thyroid homogenate.


Immunologic and biologic properties of antibodies to a glucagon-serum albumin polymer.


Paradoxical increase in acute thyroid radioiodine accumulation following hypophysectomy in iodine-deficient rats.


Effect of thyroidectomy and aminoglutethimide on adrenal function in rats.


In vitro metabolic effects of bovine growth hormone fragments in adipose tissue.


Effect of a single prepubertal injection of testosterone propionate on adult bisexual behavior of male hamsters castrated at birth.


The binding affinity and specificity of the estrogen receptor of the rat uterus and anterior pituitary.


Metabolism of progesterone by the rabbit liver.


The relationship of mitochondrial swelling to thyroxine-stimulated mitochondrial protein synthesis.


Pulmonary function in workers with chronic exposure to cadmium oxide fumes.


Behavior therapy.

Behavior therapy.


A confusion of tongues.

A confusion of tongues.


The medical model as ideology.

The medical model as ideology.


A mish-mash of theories.

A mish-mash of theories.


New techniques of new approach?

New techniques of new approach?


Psychotherapists need theories.

Psychotherapists need theories.


Group sensitvity training.

Group sensitvity training.


The psychodynamic-behavioral polemic.

The psychodynamic-behavioral polemic.


A new technology.

A new technology.


The trend to grouping.

The trend to grouping.


Behavior therapy: reply to discussants.

Behavior therapy: reply to discussants.


Sex reassignment.

Sex reassignment.


The quest of the counterculture.

The quest of the counterculture.


The socket-wrench saga.

The socket-wrench saga.


Group sensitivity training: reply to discussants.


Family therapy.

Family therapy.


Sheltered workshops for the alienated.

Sheltered workshops for the alienated.


Triadic-based therapy.

Triadic-based therapy.


A humanistic approach.

A humanistic approach.


A research strategy.

A research strategy.


Sex reassignment: reply to discussants.

Sex reassignment: reply to discussants.


An emerging entity?

An emerging entity?


A systems approach.

A systems approach.


Psychotherapy of extremely feminine boys.


Through the looking glass.

Through the looking glass.


The public arena.

The public arena.


Community mental health centers.

Community mental health centers.


The medical muddle.

The medical muddle.


Medical model: reply to discussants.

Medical model: reply to discussants.


The prevention of alcoholism.

The prevention of alcoholism.


Community mental health centers: reply to discussants.


The emperor's model.

The emperor's model.


From concept to reality.

From concept to reality.


Dilemmas in community psychiatry.

Dilemmas in community psychiatry.


Another doubtful prognosis.

Another doubtful prognosis.


The concept of neurasthenia.

The concept of neurasthenia.


A doubtful prognosis.

A doubtful prognosis.


A functional approach.

A functional approach.


Assets outweight liabilities.

Assets outweight liabilities.


Alcoholism: reply to discussants.

Alcoholism: reply to discussants.


A methodological dilemma.

A methodological dilemma.


A prophylactic myth.

A prophylactic myth.


Lithium in psychiatry: reply to discussants.


Will the real community psychiatry please stand up.


Antipsychotic and antianxiety drugs.

Antipsychotic and antianxiety drugs.


Drug treatment in psychiatry: reply to discussants.


Pot or not.

Pot or not.


Clinical vs. desk pharmacology.

Clinical vs. desk pharmacology.


Neurotic, anxious, and depressed outpatients.


Marihuana.

Marihuana.


Irrational responses.

Irrational responses.


Clinical vs. statistical sense.

Clinical vs. statistical sense.


The goal of protection.

The goal of protection.


Will-o'-the-wisp.

Will-o'-the-wisp.


Clinical not anecdotal evidence.

Clinical not anecdotal evidence.


The crime of punishment.

The crime of punishment.


Marihuana: reply to discussants.

Marihuana: reply to discussants.


An obsolete diagnosis.

An obsolete diagnosis.


Automation of psychiatric case records: reply to discussants.


The crisis in psychiatric hospitalization.


The conceptualization of deviance.

The conceptualization of deviance.


No defense needed.

No defense needed.


The ideal system.

The ideal system.


Is the crisis artificial?

Is the crisis artificial?


Radical psychiatry.

Radical psychiatry.


A time for realism.

A time for realism.


Automating narrative records.

Automating narrative records.


The crisis in psychiatric hospitalization: reply to discussants.


The concept of neurasthenia: reply to discussants.


The retreat from patients.

The retreat from patients.


Radical individualization.

Radical individualization.


Blind spots in obstetrics.

Blind spots in obstetrics.


A study of two families with multiple autoimmune disease.


A substitute for clinical thinking?

A substitute for clinical thinking?


Mesothelioma of the pleura.

Mesothelioma of the pleura.


Porcine small bowel allotransplantation.


Boon for average, bane for excellence.

Boon for average, bane for excellence.


Quantitative and qualitative changes in plasma amino nitrogen and amino acids during haemodialysis.


All power to the flowers.

All power to the flowers.


Practical radicalism.

Practical radicalism.


A generation in jeopardy.

A generation in jeopardy.


Radical goals.

Radical goals.


Synthetic amino acids and their use in fortifying foods.


The primacy of fear.

The primacy of fear.


The patient, the student, and the full-time system.


The burden of practice.

The burden of practice.


Extension and intensional anxiety.

Extension and intensional anxiety.


The persistence of ambiguity.

The persistence of ambiguity.


Reasonable fear and natural fear.

Reasonable fear and natural fear.


Retreat from patients: reply to discussants.


Isolation and structure of a biologically reduced aflatoxin B1.


Protein-deficient diet and diuron toxicity.


Metabolism of endrin in the rat.

Metabolism of endrin in the rat.


Estrogenic activity of DDT analogs and polychlorinated biphenyls.


Fate of the fungicide, 2,6-dichloro-4-nitroaniline (DCNA) in plants and soils.


Metabolism of dimethyl p-(methylthio)phenyl phosphate in animals and plants.


Metabolic degradation of O-ethyl S-phenyl ethylphosphonodithioate (Dyfonate) in potato plants.


Comparative metabolism of methoxychlor, methiochlor, and DDT in mouse, insects, and in a model ecosystem.


Papilloedema and its diagnosis.

Papilloedema and its diagnosis.


Expulsive haemorrhage (a case report).

Expulsive haemorrhage (a case report).


Bilateral orbital involvement in multiple myelomatosis.


Morphological studies of extraocular muscles in cases of microcornea.


Sympathetic ophthalmitis with total deafness (a case report).


A case of gumma of the ciliary body.

A case of gumma of the ciliary body.


Oculo-auricular dysplasia. (A case report).


Chelation of uranyl ions by adenine nucleotides. IV. Nuclear magnetic resonance investigations, hydrogen-1 and phosphorus-31, of the uranyl-adenosine 5'-diphosphate and uranyl-adenosine 5'-triphosphate systems.


On the origin of carbon 1 in tetrahydroisoquinoline alkaloids.


Selective cyanylation of sulfhydryl groups.


Reaction of the active site of papain with a "reporter" group labeled phenacyl halide.


Determination of pyribenzamine (tripelennamine) residues in bovine milk.


Dieldrin accumulation in tissues of the sheep.


Nybomycin. 3. A revised structure.

Nybomycin. 3. A revised structure.


Nybomycin. IV. Total synthesis of deoxynybomycin.


The flow birefringence of persistence length deoxyribonucleic acid. Hydrodynamic properties, optical anisotropy, and hydration shell anistropy.


Idiopathic scoliosis. Analysis of curve patterns and the preliminary results of Milwaukee-brace treatment in one hundred sixty-nine patients.


Free amino acids during germination of gamma-irradiated groundnut.


Fractures, dislocations, and fracture-dislocations of the spine.


Cast-brace treatment for fractures of the distal part of the femur. A prospective controlled study of one hundred and fifty patients.


Fluoroalkanesulfonanilides, a new class of herbicides.


Proton magnetic resonance spectroscopy of thiocarbamate herbicides.


Relations between the fatigue life and histology of adult human cortical bone.


Characterization of alkylation products of diethyl phosphorothioate.


Estimation of lysine and sulfur amino acids by short ion exchange column method.


The effect of limb elevation in preventing venous thrombosis. A venographic study.


Compression fracture of the anterior articular surface of the calcaneus.


Bacterial (suppurative) arthritis in the adult.


Intravenous lidocaine anesthesia for upper extremity fractures and dislocations.


An unusual complication of a below-the-knee cast. A case report.


Traumatic occipito-atlantal dislocation.


Symptomatic enlargement of the tuberosity of the radius causing snapping in the forearm.


Kirner's deformity of the little finger. Case reports and proposed treatment.


Unusual dislocation of symphysis pubis with locking. A case report.


Ewing's tumor of the talus. A case report.


Paralytic valgus deformity of the foot. Treatment by replacement of paralyzed tibialis posterior muscle: a long-term follow-up study.


Criteria for determining the proper level of amputation in occlusive vascular disease.


Fracture of the intercondylar eminence of the tibia.


Conservative approach in the treatment of fractures of the calcaneus.


The lateral position for operations on the upper extremity.


An improved approach for obturator neurectomy for cerebral spastic paralysis.


The biosynthesis of human growth hormone and prolactin.


Growth hormone antibodies in patients treated with different preparations of human growth hormone (HGH).


Determination of the endogenous component of alimentary lipemia.


The influence of age on the phosphaturic response to induced hypocalcemia in man.


Radioimmunoassay for triiodothyronine: A preliminary report.


Characteristics of the amino acid transport system in the mucosal border of rabbit ileum. The specificity of the neutral amino acid transport system in the brush border was examined by studying the ability of amino acid analogues to inhibit the unidirectional influx of phenylalanine from mucosal solution into the cells. Effects were evaluated in terms of the affinity of various substrates for the amino acid site in the transport system. The affinity of amino acids for the site was proportional to the number of carbon atoms in the side chain. Electron-withdrawing substituents in the ring of phenylalanine increased affinity and electron-releasing groups decreased affinity. Removal of the alpha-amino group from phenylalanine decreased affinity by a factor of approximately 50 and removal of the carboxyl group decreased affinity 12-fold. Effects on affinity of variations in the side chain of the amino acid can be comparable in magnitude to that of the carboxyl group. The effect of sodium ion on the transport system appears to be similar for all compounds tested.


Potassium exchange and afterpotentials in frog sartorius muscles treated with glycerol. The potassium exchange properties of glycerol-treated sartorius muscles of the frog were determined. Potassium ((42)K) uptake, efflux, and net flux were measured in the presence of glycerol and at various times after exposure to glycerol and return to isotonic Ringer solution. Potassium uptake was not altered by the presence of glycerol but was reduced on the average 53% after glycerol treatment. Efflux transiently increased in the presence of glycerol and was reduced 37% after glycerol removal. Consequently, there was a net loss of intracellular potassium as well as a gain of sodium. In contrast to the irreversible alterations of potassium exchange induced by glycerol treatment, action potentials with normal negative afterpotentials (N.A.P.) were elicited 4-5 hr after glycerol removal. The reappearance of the N.A.P. was associated with a return of the membrane potential to normal values (90 +/- 2 mv). However, the response of these muscles to reduced extracellular potassium was anomalous. In K(+)-free Ringer solution the average resting membrane potential was 74 +/- 3 mv and a positive afterpotential of 11 +/- 3 mv was associated with the action potential.


Energy production in cardiac isotonic contractions. The energy output of rabbit papillary muscle is examined and it is shown that there is more energy liberated in an afterloaded isotonic contraction than in an "equivalent" isometric contraction. This statement holds true regardless of whether equivalence is based on the proposition that tension or the time integral of tension is the best index of muscle energy expenditure. Besides the external work performed there is additional heat production in isotonic contractions and this heat increases as the afterload is decreased. The additional heat is more evident when tension rather than the time integral of tension is made the determinant of energy expenditure. It is shown in single contractions that the rate of isotonic heat production, regardless of afterload size, never exceeds the heat rate recorded in an isometric contraction at the same initial length. Experiments reveal no simple linear correlation between isotonic energy output and contractile element work. Problems associated with the compartmentalization of the energy output of a contraction are discussed.


The cellular transport of magnesium in rat liver. The bidirectional transport of Mg in rat liver was studied using slices labeled with (28)Mg in a closed two-compartment system under steady-state conditions. The influx (K(bs)) and efflux (K(sb)) transfer coefficients governing transport between the extracellular phase and a rapidly exchanging cell fraction were 0.074 and 0.019 per min, respectively. An increased extracellular concentration of Mg(++) caused a 30% decrease in K(bs) and a 31% increase in K(sb). A decreased extracellular Mg(++) had an opposite effect. At 0 degrees C, both transfer coefficients were reduced by 65%. Increased pH and NaCN increased transport, whereas Ca(++) reduced transport. Reduced pH, altered Na(+):K(+) ratio, Sr(++), glucose deletion, iodoacetate, ethanol, and lactate had no significant influence. Dinitrophenol reduced K(sb) but had no effect on K(bs). These data support the thesis that the intracellular concentration of Mg is in part regulated by a reciprocal change in the influx transfer coefficient and a parallel change in the efflux transfer coefficient in response to altered extracellular concentrations of Mg(++). The qualitative and quantitative similarities of Mg and Ca transport in this system suggest that Mg and Ca share a common transport mechanism which is primarily dependent upon the binding of these divalent cations to macromolecular ligands within the cell membrane or within the cell.