Isolation of the plasma membrane of the luminal surface of rat bladder epithelium, and the occurrence of a hexagonal lattice of subunits both in negatively stained whole mounts and in sectioned membranes. A method of isolating the thick luminal membrane from homogenates of bladder epithelium is described, which entails pretreatment of the epithelium with fluorescein mercuric acetate and centrifugation of the homogenate on sucrose density gradients. A hexagonal array of hexamers is illustrated by negative contrast staining in whole mounts of the isolated thick membrane. Subunits are also shown in tangential sections of this thick membrane, in fixed, embedded bladder epithelium. The significance of the subunits is discussed in the context of membrane structure and permeability.


Aberrant intranucleolar maturation of ribosomal precursors in the absence of protein synthesis. To help elucidate the role of protein in the maturation of ribosomal RNA in cultured L cells, we have studied the effects of cycloheximide upon the maturation process and upon the intranucleolar ribonucleoprotein particles containing the "preribosomal RNA's." Five parameters of these particles were analyzed: (a) extractability, (b) sedimentation characteristics in sucrose gradients, (c) RNA composition, (d) buoyant density in CsCl gradients, and (e) effects of increased ionic strength on the buoyant density. When protein synthesis is inhibited, the rate of conversion of the precursor 45S ribosomal RNA is rapidly diminished, falling to less than 30% of the control rate within 1 hr. Nevertheless, in terms of the first three parameters there is no difference between control and cycloheximide nucleolar particles. However, the cycloheximide particles have a lower and more heterogeneous buoyant density and a more variable response to increased ionic strength. The results imply that the protein composition of the cycloheximide particles is different from that of particles from control cells, and that the entire protein complement is not necessary for the first cleavages in the maturation process, although it is necessary for the normal rate of processing and for the eventual appearance of both 18S and 28S rRNA in mature ribosomes.


Peroxidase activity in rat liver microbodies after amino-triazole inhibition. The in vivo effects of 3-amino-1,2,4-triazole (AT) on the fine structure of microbodies in hepatic cells of male rats has been studied by the peroxidase-staining technique. Within 1 hr of intraperitoneal injection AT abolishes microbody peroxidase-staining, and the return of staining coincides temporally with the known pattern of return of catalase activity following AT inhibition; this is further evidence that the peroxidase staining of microbodies is due to catalase activity. Peroxidase staining reappears in the microbody matrix without evidence of either massive degradation or rapid proliferation of the organelles. Furthermore, during the period of return of activity, ribosomal staining occurs adjacent to microbodies whose matrix shows little or no peroxidase staining. These observations are interpreted as evidence that (a) catalase is capable of entering preexisting microbodies without traversing the cisternae of the rough endoplasmic reticulum or the Golgi apparatus, and that (b) the ribosomal staining is probably not cytochemical diffusion artifact and may represent a localized site of synthesis or activation of catalase.


Further biochemical and morphological studies of granule fractions from rabbit heterophil leukocytes. Fractionation of rabbit heterophil leukocyte homogenates by isopycnic centrifugation as well as by zonal sedimentation has helped to characterize further the particulate components of these cells. Four classes have been identified: (A) Large (0.5-0.8 microm) and dense (1.26) azurophil or primary granules, containing all the myeloperoxidase, one-third of the lysozyme, and a major proportion of the lysosomal acid hydrolase activities of the cells. (B) Smaller (0.25-0.40 microm) and less dense (1.23) specific or secondary granules, containing 90% of the alkaline phosphatase and the remainder of the lysozyme activities, but very little if any acid hydrolases. (C) Particles of low density (1.20), containing the remainder of the lysosomal acid hydrolases. This fraction was heterogeneous, but showed abundant small rod- or dumbbell-shaped particles of moderate electron opacity, surrounded by a single membrane (tertiary granules?). The possible origin of these lysosomes from contaminating macrophages could not be ruled out but appeared unlikely. (D) Slowly sedimenting material of very low density (1.14), made up of large, empty vesicular membrane structures, and containing 10% of the alkaline phosphatase, and all of a thiol-dependent acid p-nitrophenyl phosphatase, an enzyme clearly different from the lysosomal acid phosphatase.


On the reconstitution of the crystalline components of the sea urchin fertilization membrane. The characteristics of the reconstitution of a crystalline component of the sea urchin fertilization membrane are presented. The reassembly of large aggregates of cylindrical or tubular components is effected by the addition of calcium or other divalent cations. The reassembly requires a slightly alkaline pH and is little affected by increasing ionic strength. Reassembly is strongly inhibited by treatment with reducing agents such as dithiothreitol. The role of this protein in the formation of the fertilization membrane and its possible relation to the calcium-insoluble proteins of the mitotic apparatus are discussed.


Ribosome synthesis in Tetrahymena pyriformis. The cellular site of synthesis of ribosomal RNA in Tetrahymena pyriformis was studied by analyzing the purified nuclear and cytoplasmic RNA from cells pulse labeled with uridine-(3)H. The results of studies using zonal centrifugation in sucrose density gradients show that the ribosomal RNA is synthesized in the nucleus as a large precursor molecule sedimenting at 35S. The 35S molecule undergoes rapid transformation through two main nuclear intermediates, sedimenting at about 30S and 26S. The smaller ribosomal RNA (17S) appears first in the cytoplasm and it seems to be absent from the nucleus. The apparent delay in the appearance of the larger ribosomal RNA (26S) in the cytoplasm is due to the presence of a larger pool of its precursors in the nucleus as indicated by pulse-chase experiments. The newly synthesized ribosomal RNA's appear in the cytoplasm as discrete 60S and 45S ribonucleoprotein particles, before their incorporation into the polysomes.


Selective antibody transport in the proximal small intestine of the neonatal rat.


Zonation of hemoprotein P-450 and cytochrome b5 in the adrenocortex of mammals.


The possible role of the vesicles in renal ammonia excretion. An implication of concentrated glutamic oxalacetic transaminase.


A stereoscope observation of tracheal epithelium of mouse by means of the high voltage electron microscope.


Migration of glycoprotein from golgi apparatus to cell coat in the columnar cells of the duodenal epithelium.


Treatment of Proteus meningitis with carbenicillin: a report of four cases.


Pharmacokinetics of carbenicillin in patients with hepatic and renal failure.


Carbenicillin: in-vivo synergism and combined therapy.


Carbenicillin in therapy of systemic infections due to Pseudomonas.


Shaving and hair growth.

Shaving and hair growth.


Enzymatic hydrolysis of the alpha-protein of epidermis.


Non-specific lymphocyte transformation in vitro by nickel acetate. A possible source of errors in lymphocyte transformation test (LLT).


The pathophysiology and treatment of pulmonary contusions.


The problem of contused lungs.

The problem of contused lungs.


Perforating wounds of the heart caused by central venous catheters.


Snowmobile accidents: a review of injuries sustained in the use of snowmobiles in northern New England during the 1968-69 season.


Delayed acrylic reconstruction of the skull in craniocerebral trauma.


Surgical treatment of pancreatic trauma.


The epidemiology of snowmobiling injuries.


Organizing to improve emergency medical services: birth of the University Association for Emergency Medical Services.


Renin assays in hypertension: the use of peripheral renin as a screening test.


A comparison of renal function in spinal cord injury patients with and without reflux.


Pyeloduodenal fistula due to tuberculosis.


The changing concept of hypernephroma.

The changing concept of hypernephroma.


Partial nephrectomy for carcinoma in a congenital solitary kidney.


Intraoperative pulmonary embolectomy: case report.


The management of ureteral obstruction with silicone rubber splint catheters.


An experimental model of ureteral colic.


Experiments in ureterosigmoidostomy: transureteroureterostomy combined with ureterosigmoidostomy to allow a single ureterocolic anastomosis.


Abnormal hydrodynamics during vesicoureteral regurgitation.


Urinary retention associated with herpes zoster.


The association of benign bladder papilloma with cancers of sites other than the bladder and ureter.


Carcinoma of the penis involvi skin of base.


Scrotal pneumatocele as an unusual sign of pneumoperitoneum: report of a case and review of the literature.


Effect of stilbestrol on the isoenzymes of lactate dehydrogenase in benign and malignant prostatic tissue.


Retropubic seminal vesiculectomy for chronic seminal vesiculitis with preservation of potency.


Fourteen-hour concentrated urine osmolality as a renal function test in children.


Sulfonamide crystalluria: a forgotten disease.


Effects of glucose on the subcellular structure of the rat liver cells in acute ethionine intoxication.


Dynamics of liver cell injury and repair. I. Spontaneous reformation of the nucleolus and polyribosomes in the presence of extensive cytoplasmic damage induced by ethionine.


Electron microscopic study of phagocytosis of Histoplasma capsulatum by hamster peritoneal macrophages.


On calculating volumes of transsected bodies from two-dimensional micrographs.


The occurrence of lysosome-like structures in sickling erythrocytes.


Postmortem observations on Fischer rats with leukemia and other disorders.


Surgical treatment of reflux esophagitis and stricture associated with permanent incompetence of the cardia.


Larva of Scenopinus sp. (diptera: scenopinidae) causing human urogenital myiasis?


The modified Robert Jones dressing.

The modified Robert Jones dressing.


The parasellar syndrome: problems in determining etiology.


Simultaneous renal clearances of 125I- and 131I-labelled orthoiodohippurate and para-aminohippurate in the estimation of effective renal plasma flow in man.


Calcaneal osteotomy in the treatment of the cavovarus foot.


Rheumatoid arthritis and papilledema. Résumé of case.


Adult lean body mass declines with age: some longitudinal observations.


Glucose tolerance and time sequence of adiposity, hyperinsulinemia and hyperglycemia in obese-hyperglycemic mice (obob).


Characteristics of galactose-1-phosphate uridyl transferase in intestinal mucosa of normal and galactosemic humans.


Complications of diuretic therapy: severe alkalosis and syndrome resembling inappropriate secretion of antidiuretic hormone.


The effect of fluoride on the reactions of methanesulfonates with acetylcholinesterase.


Uncoupling action of sulfonylureas on brown fat cells.


Biochemical effects of niridazole on Schistosoma mansoni.


The metabolism of ribonucleic acid in rat liver after phenobarbital administration.


The effect of chloroquine on the enzymatic hydrolysis of nucleic acids.


Epidemic fears exaggerated.

Epidemic fears exaggerated.


Government chemist allays fears.

Government chemist allays fears.


MRC-university symbiosis.

MRC-university symbiosis.


NAS, AAAS to report on Vietnam defoliation.


1 detergent for another.

1 detergent for another.


Interest in exine.

Interest in exine.


Selective synthesis of a nuclear acidic protein in liver cells stimulated by cortisol.


Selective constraints on amino-acid substitutions during the evolution of proteins.


Fk-lac, an episome with unusual properties found in a wild strain of a Klebsiella species.


Effect of surface charge on the steady-state potassium conductance of nodal membrane.


Effects of anti-lymphocyte serum on uptake of uridine by lymph nodes during carcinogenesis.


Copper in hepatocyte lysosomes of the toad, Bufo marinus L.


Metabolism of diethylnitrosamine by human liver slices in vitro.


Role of the acid moieties in the toxic actions of pyrrolizidine alkaloids on liver and lung.


Stability of cardiac monoamine oxidase activity after chemical sympathectomy with 6-hydroxydopamine.


Effects of morphine and its antagonists on release of cerebral cortical acetylcholine.


Production of poly-unsaturated ruminant body fats.


Effects of high levels of yeast feeding on uric acid metabolism of young man.


New process for reducing the nucleic acid content of yeast.


Internal muscle in the eye of an insect.


Quantitative assessment of the flight of Archaeopteryx.


Analysis of running and the preduction of ultimate performance.


Choices of parenthood.

Choices of parenthood.


Wasting waste.

Wasting waste.


Air pollution surveillance systems.

Air pollution surveillance systems. Atmospheric surveillance is necessary in order to identify airborne pollutants, to establish ambient concentrations of these pollutants, and to record their trends and patterns. Air pollutants may occur in the form of gases, liquids, and solids, both singly and in combination. Gaseous pollutants make up about 90 percent of the total mass emitted to the atmosphere with particulates and aerosols accounting for the remaining 10 percent. Small particulates are of particular importance because they may be in the respirable size range. These small particles may contain biologically active elements and compounds. Furthermore, they tend to remain in the atmosphere where they interfere with both solar and terrestrial infrared radiation, which may affect climate on a global basis.


Cancer research: Senate consultants likely to push for planned assault.


Atmospheric aerosol: does a background level exist? Measurements of light-scattering made with an integrating nephelometer at Point Barrow, Alaska, and Mount Olympus, Washington, are in agreement in magnitude, and both sets of measurements also are in agreement with other measurements of light-scattering and turbidity made in remote locations. This agreement suggests that a background level of aerosol exists and that the concept of a background is applicable.


Humic substances: fulvic acid-dialkyl phthalate complexes and their role in pollution. Fulvic acid is a water-soluble humic material with relatively low molecular weight that occurs widely in soils and waters. It can combine with lyophobic organic compounds such as alkanes, fatty acids, and dialkyl phthalates to form stable "complexes" that are soluble in water. Fulvic acid in an aquatic environment may act as a vehicle for the mobilization, transport, and immobilization of organic compounds, some of which may be toxic pollutants.


Sulfur: simulated long-range transport in the atmosphere. One way to examine the question of whether or not air pollutants are transported over distances on a continental scale is by numerical simulation. A simple atmospheric transport and accumulation model, together with mean wind data and an estimated source distribution in Western Europe, were used in this study. The results suggest that Great Britain and Central Europe contribute to the observed concentrations of sulfur in Northern Europe.


Pigeon control by chemosterilization: population model from laboratory results. Reproductivity of pigeons is inhibited with mestranol incorporated in a synthetic grit; continual erosion releases daily doses. Young squabs may be permanently sterilized when fed crop milk by treated birds. A theoretical model of pigeon population dynamics using laboratory-obtained data shows the advantages of chemosterilization over killing as a means of pigeon control.


Water transport in the cloaca of lizards: active or passive? The withdrawal of water from the lizard cloaca can be a passive process resulting from the colloidal osmotic pressure of the plasma proteins. The forces necessary to withdraw water from lizard urine, the forces prevailing within the cloaca in vivo, and the counterbalancing of these forces by a protein solution placed in the cloaca all are in accord with this hypothesis.


Amygdaloid nucleus: new afferent input from the vomeronasal organ. Terminal degeneration stained by the Fink-Heimer technique was found in the medial and cortical amygdaloid nuclei in a discrete zone after lesions were inflicted in the accessory olfactory bulb but not after lesions were made in the main olfactory bulb in the rabbit. Since the accessory olfactory bulb receives the endings of the vomeronasal nerve, the mediocortical complex of the amygdala is the central projection area for the vomeronasal sensory organ. The vomeronasal organ is seen as having new potential significance in sexual and feeding behavior because the cortical amygdaloid nucleus projects to the anterior, medial hypothalamus and the ventromedial nucleus.


Microelectrophoresis of biogenic amines on hypothalamic thermosensitive cells. The rat hypothalamus contains thermally insensitive, normally sensisitive, and highly thermosensitive cells. The responses of thermosensitive neurons to microelectrophoretically applied acetylcholine, norepinephrine, and 5-hydroxy-tryptamine were the same in both rats and cats. The firing rate of warm-sensitive interneurons was accelerated by acetylcholine and inhibited by norepinephrine. The firing rate of cool-sensitive interneurons was accelerated by norepinephrine and, in one case, was inhibited by 5-hydroxytryptamine. Thermodetector cells were relatively insensitive to these amines, but were sensitive to current flow. These results from the rat, but not from the cat, agree with the data for thermoregulatory responses following microinjection of these amines into the hypothalamus.


Estrogenic induction of ornithine decarboxylase in vivo and in vitro. Injection of estrogens (17beta-estradiol or diethylstilbestrol) into immature chicks results in a marked (30- to 50-fold) increase in the ornithine decarboxylase activity of oviductal homogenates within a 4-hour period. Similar stimulations were obtained when estrogen was injected into hypophysectomized or castrated rats and the uterus was examined for decarboxylase activity. An elevation of decarboxylase activity was obtained in vitro when oviducts from immature chicks were incubated in the presence of estrogen. These data indicate a direct action of estrogen on oviduct tissue to promote a rapid increase in the activity of a specific enzyme and represent the first example of a completely in vitro enzyme response to estrogen.


Acetylcholine concentrations in rat brain: diurnal oscillation. A diurnal oscillation of acetylcholine concentrations in rat brain has been demonstrated by gas chromatography. Peak concentrations occur at 2 hours of light, and a trough is seen at 6 hours of darkness. This pattern is observed only in grouped rats, and emerges after at least 18 days of prior conditioning in an environment with controlled light, humidity, and temperature.


Mammalian evolution: is it due to social subordination?


Brain enhancement in tadpoles: increased DNA concentration after somatotrophin or prolactin. Frog tadpoles, injected with prolactin or somatotrophin during early stages when the brain cell population is rapidly increasing, exhibited marked increases over sham-injected controls in body weight, brain weight, and brain DNA, throughout subsequent development. Animals treated with somatotrophin attained the increase in brain DNA during the infection period. Prolactin had little effect during this period, but brain DNA accumulation continued at an accelerated rate over the next 15 days, when the rate of DNA increment normally declined. Patterns of incorporation of tritiated thymidine confirmed that both hormones increased DNA accumulation, suggesting increased cell proliferation rather than decreased cell death.


Advances in human genetics and their impact on society.


Bioresources of shallow water environments.


Medical editors' dilemma.

Medical editors' dilemma.


Ekistics, the science of human settlements.


Psychological and social barriers to women in science. Commitment and creativity in science are not merely a function of an individual's competence or excellence, but are a product of the social environment as well. Acceptance and recognition from significant other people (one's peers and other professionals), and opportunities for stimulating and challenging interaction are essential for developing a strong occupational or professional identiy, and for creating the inner sense of role competence which can lead to greater commitment and productivity in professional work. Unfortunately women, especially those who have experienced interrupted or discontinuous careers, find such opportunities and acceptance difficult to obtain.


Nixon's science adviser: genesis, progress of a surprise appointment.


Blood velocity measurements in intact subjects. Venous blood velocities in intact human forearms can be measured by the use of nuclear magnetic resonance techniques. In essence, two separated coils are placed over the vein, and the arm is held in a magnetic field. Radio-frequency energy in one coil "flips" over the protons in the blood stream, and the second coil detects the arrival of the "flipped" protons. Human blood in vivo and in vitro has a nominal nuclear magnetic resonance relaxation time of 0.4 second.


Bimodal sedimenting zones due to ligand-mediated interactions. Ligand-mediated association-dissociation reactions can give rise to band sedimentation patterns showing bimodal bands despite instantaneous establishment of equilibrium. Weaker interactions result in unimodal bands whose sedimentation coefficients decrease with time of sedimentation and in characteristic patterns of total ligand. The implications of these results for fundamental investigations of protein interactions and for conventional analytical applications of zone sedimentation and molecular sieve chromatography are considered.


Macrophage membranes viewed through a scanning electron microscope. When rabbit peritoneal macrophages were cultured in serum and Tyrode medium, numerous membranous structures varying in size and transparency were observed to cover the surface in complex cascading patterns. Modifications in the methods of fixation and drying probably accounted for the new perspective of macrophage surfaces gained in this study.


Echo-ranging neurons in the inferior colliculus of bats. Bats measure the distance to an object in terms of the time lag between their outgoing orientation sounds and the returning echo. For measurement of the time lag, the latency of response of a neuron to a stimulus must be nearly constant regardless of the stimulus amplitude and envelope. Otherwise, a large error would be introduced into the measurement. Bats have neurons that are specialized for echo ranging.


Histamine production by transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis. A transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis contained appreciable amounts of histamine. Dialyzed, microsome-free supernatant of tumor tissue produced definite amounts of histamine in the presence of L-histidine and pyridoxal phosphate. These findings may relate to hypersecretion of gastric acid and formation of multiple ulcers in the stomach and duodenum of Mastomys bearing carcinoids.


Phenylthioacetate: a useful substrate for the histochemical and colorimetric detection of cholinesterase. Cholinesterase from frozen sections of honey bee (Apis mellifera, L.) brain hydrolyzes phenylthioacetate and acetylthiocholine to give virtually identical patterns of enzyme distribution with and without the use of paraoxon. In addition, phenylthioacetate is an economical substrate for in vitro and in vivo studies of cholinesterase. Phenylthioacetate offers the advantages of being easily synthesized and lipoid soluble, and appears to penetrate membranes easily.


Trisomy-3,4 and triploidy (3A-ZZZW) in chick embryos: autosomal and sex chromosomal nondisjunction in meiosis. The first known cases of trisomy-3, trisomy-4, and triploidy (3A-ZZZW) in chickens are reported. The trisomic embryos were near death at 4 days of incubation; the triploid embryo appeared normal and probably could have developed further. Although the triploid (3A-ZZZW) was found after sampling more than 2000 embryos, the trisomic-3 and trisomic-4 embryos were discovered in the first sampling of a line of chickens selected for low egg production. These studies suggest that the sex chromosomes (Z and W), as well as the autosomes, can undergo nondisjunction in meiosis of chickens.


Plasticizers from plastic devices extraction, metabolism, and accumulation by biological systems. Phthalate ester plasticizers were found to be extracted by blood from plastic tubing and from plastic bags used for blood storage. One such plasticizer was metabolized by the isolated perfused rat liver while another was found to be accumulated in the liver unchanged. In addition, this latter plasticizer was identified in samples of human tissue taken from patients who had received transfusions of blood stored in plastic bags. The biological implications of these observations are considered.


Shear degradation of fibrinogen in the circulation. Plasma fibrinogen in vitro suffers a loss in clottability due to shearing. From calculation of the mass average shear to which plasma is subjected in the circulation, it is estimated that the half-life of fibrinogen is 4 days. This is in excellent agreement with reports that the half-life of fibrinogen in the circulatory system is 4 to 5 days. Hence shearing may be the mechanism for fibrinogen degradation in the circulatory system.


International Biological Program.

International Biological Program.


Serum histidine levels in atopic dermatitis patients.


Primary tumors of the duodenum.

Primary tumors of the duodenum.


A twelve year psychiatric follow-up of gastrectomy patients.


Congenital heart disease in the immediate neonatal period: differential diagnosis.


Surgical Grand Rounds from the University of Mississippi Medical Center.


Cholecystostomy, a definitive procedure in the aged.


Control of allergy and humidity in secretory otitis media of children: an analysis of 423 cases.


Characteriological deterrants to economic progress in people of Appalachia.


The management of the vitreous in injuries of the eye.


The prevention of postoperative renal failure.


Spontaneous gangrene of the colon, with emphasis on the left colon.


Carbamylcholine (carbachol) in the management of corneal trauma and after cataract extraction: an experimental and clinical study.


Cephalothin as a preventive antibiotic.

Cephalothin as a preventive antibiotic.


Appalachia and the like.

Appalachia and the like.


The management of head injuries in adults.


Early management of head injuries in children.


Fundus angiography in man by intracarotid administration of dye.


Infectivity and some physicochemical characteristics of rubella virus ribonucleic acid.


Tobacco ringspot virus in the nematode Xiphinema americanum.


Infection of apical initials in tobacco shoot meristems by tobacco ringspot virus.


Ultrastructure of potato infected with potato virus M.


Sequential reconstitution of tobacco mosaic virus.


Polyethylene glycol solubility gradients, a new and rapid technique for investigations of plant viruses.


Characterization of the DNA of herpesviruses associated with Lucké adenocarcinoma of the frog and Burkitt lymphoma of man.


Studies on mixed infection with Newcastle disease virus. IV. On the structure of heterozygotes.


Infection of barley by tobacco mosaic virus in single and mixed infection.


Isolation and characterization of two species of double-stranded RNA from tobacco leaves doubly infected with tobacco necrosis and satellite tobacco necrosis viruses.


Uncoating of tobacco mosaic virus ribonuleic acid after inoculation of tobacco leaves.


Effects of tobacco mosaic virus infection on photosynthetic CO2 fixation and 14CO2 incorporation into protein in tobacco leaves.


Glycopeptides of vaccinia virus. I. Preliminary characterization and hexosamine content.


Poliovirus antibody status three years after vaccination with trivalent oral vaccine.


Function of the left atrial receptors.

Function of the left atrial receptors.


Creatinine excretion as index for estimating urinary excretion of micronutrients or their metabolic end products.


Immunohematology proficiency testing, 1966-1969.


Esophageal manomtry in clinical medicine.


Mannitol osmotic diuresis in patients with chronic renal failure.


Conjunctival biopsy for the biochemical diagnosis of cystinosis.


Thermosensitive neurons in tuberal and posterior hypothalamus of cats.


Neurochemical studies of the affective disorders: the pharmacological bridge.


Arteriography in neurovascular compression at the thoracic outlet, with special reference to embolic patterns.


New cross compression forceps for carotid angiography.


Severe reflex algodystrophy (Sudeck's atrophy) as a complication of myelography: report of two cases.


Television fluorodensitometry. A simple and rapid method for the evaluation of image intensifier-television systems.


Uneventful perforation of a coronary artery during selective arteriography. A case report.


Postoperative pancreatitis. A study of seventy cases.


Nigropallidal encephalomalacia in horses fed Russian knapweed--Centaurea repens L.


The effects of ozone, nitrogen dioxide, and sulfur dioxide on the experimentally induced allergic respiratory disorder in guinea pigs. I. The effect on sensitization with albumin through the airway.


Partial substitution of serum in hematopoietic cell line media by synthetic polymers. Several synthetic polymers (hydroxyethyl starch, sodium carboxymethyl cellulose, polyvinylpyrrolidone) markedly improved the growth of three human lymphocyte cell lines [Roswell Park Memorial Institute (RPMI) 1348, 1788, and 8098]. Growth was stimulated when each of these polymers was added to RPMI 1640 medium supplemented with only 2% fetal bovine serum. Dextran T-40, T-70, and T-110 varied in their effect on the growth of these cell lines. Dextran T-250 and Haemaccel did not improve cell yields when partially substituted for the serum. The successful partial substitution of polymers for serum was specific for individual cell lines.


Comparison of the effects of some C27-, C21-, and C19-steroids upon hepatic sterol synthesis and hydroxymethylglutaryl-CoA reductase activity.


Evidence of a hydrazine-reactive group at the active site of the nonheme portion of horseradish peroxidase.


Pyridoxal phosphate-catalyzed alpha-beta elimination of lanthionine and cystathionine.


Insulin and protein synthesis in muscle.


Purification and characterization of enolases from coho (Oncorhynchus kisutch) and chum (Oncorhynchus keta) salmon.


Vitamin A and ribonucleic acid synthesis in rat intestine.


Optical rotatory dispersion and circular dichroism studies on insulin and its trypsin-modified derivatives.


Polypeptide subunits of lipovitellin. II. Resolution and characterization.


Incorporation of leucine-14C and lysine-14C into protein in the developing endosperm of normal and opaque-2 corn.


Rat liver oxidative N-dealkylase and N-oxidase activities as a function of animal age.


The biosynthesis of isoprenoid lipids including ubiquinone in muscle from normal and genetically dystrophic mice.


Biosynthesis of bacterial glycogen. 8. Activation and inhibition of the adenosine diphosphoglucose pyrophosphorylase of Rhodopseudomonas capsulata and of Agrobacterium tumefaciens.


Synthesis of L-thyroxine from 3,5-diiodo-L-tyrosine by nonenzymic transamination.


Isolation and characterization of phospholipase A from sea snake, Laticauda semifasciata venom.


The effects of phentolamine, tolazoline and phenoxybenzamine on the response of the isolated spleen strip to electrical stimulation and noradrenaline.


Effect of hypotension on sensitivity of minute cerebral vessels.


A comparative study of the pharmacologic actions of amphetamine and fenfluramine.


Head bobbing associated with third ventricular cyst. Report of a case.


Antibody response to Salmonella heidelberg in turkeys.


Anatomic and physiologic studies of the ocular circulation using microsurgical techniques.


Antagonism by adenine in the nutrition of Schizosaccharomyces pombe mutants. Inhibition at the level of guanine uptake.


Study of DNA conformation in native, partial and reconstituted nucleohistones, using hydrodynamic methods and optical rotatory dispersion.


Castor bean lipase: specificity of action.


Metabolic activity in single supraoptic neurones and its relation to osmotic stimulation.


The increased response of chronically de-efferented rat muscle spindles to stretch.


Midbrain regions relevant to auditory communication in songbirds.


Overcrowding in mental hospitals.

Overcrowding in mental hospitals.


Two haemoglobins Q, alpha-74 (EF3) and alpha-75 (EF4) aspartic acid to histidine.


Spectrophotometric determination of mercury (II) by solvent extraction with variamine blue B.


Transformation of progesterone by Rhizopus nigricans REF 129 as influenced by modification of the fermentation medium.


Impulse noise and neurosensory hearing loss. Relationship to small arms fire. The problems of noise are not limited to the simple annoyance of an individual. Noise can produce a permanent hearing handicap. Many everyday activities and hobbies are associated with hazardous exposure to noise. The hunter and the sport shooter are potential subjects of severe and unresolvable hearing loss.Noise-induced hearing loss develops insidiously. The means of prevention are far more simple than is correction of the loss. Wearing ear protectors, plugs or earmuffs, is advisable during exposure to hazardous noise.


The influence of management and bovine serum protein on the incidence of diarrhea in calves.


Reaction of polycyclic hydrocarbon-cysteine conjugates with the aminoacyl-RNA synthetase system.


Uptake and clearance of 9, 10-dimethyl-1, 2-benzanthracene-9-14C by mammary parenchymal cells of the rat.


Stimulation of growth of transplantable tumors by genes which promote spontaneous tumor development.


A collaborative study of the serum calcium determination by atomic absorptn spectroscopy.


Normal concentrations of lactate, glucose, and protein in cerebrospinal fluid, and the diagnotic implications of abnormal concentrations.


Conversion of 3-oxo-23,24-dinor-4-cholen-22-al into progesterone by the action of amine salts in dimethylformamide.


Peak characteristics and computers in continuous flow analysis.


The preservation of urine specimens for delta-aminolevulinic acid determination.


Effect of dextrans on o-toluidine methods for glucose.


Revision in flame photometric Li determination.


Disc electrophoresis of lipoproteins: a reinterpretation of the chylomicron band.


Choosing a course of action.

Choosing a course of action.


The psychopathologist--what man of science?


Justice in the therapeutic state.

Justice in the therapeutic state.


A brief follow-up rating.

A brief follow-up rating.


The prosthetic man.

The prosthetic man.


Macrocosm and microcosm: the interfaceof anthropology and clinical psychiatry.


Hormone therapy for cancer. I. Leukemias and malignant lymphomas.


Age and phenylalanine.

Age and phenylalanine.


Effect of various steroids on microsomal aliphatic hydroxylation and N-dealkylation.


Influence of hypothermia on eye nystagmus.


Coccidiosis: problems involved in obtaining reliable field data.


Anticoccidial drugs: introductory remarks on techniques in battery trials.


Long-term monitoring during clofibrate therapy.


Regeneration of limbs in adult Rana ridibunda ridibunda ridubunda Pallas.


Diver performance in cold water.

Diver performance in cold water.


Family therapy in Czechoslovakia: an aspect of group-centered psychotherapy.


CPC No.220(II) at the Second Tokyo National Hospital.


The role of xoxygen and nitrogen bases in the lysis of acyl-activated esters. Cobalt 3 chelated glycine isopropyl ester.


Artificial rearing of lambs: feeding cold milk ad libitum versus warm milk three times per day to appetitie, and effects of an antibiotic-vitamin-iron supplement on growth performance and digestibility of diet constituents.


Influence of calcium source, phosphorus level and acid--base-forming effects of the diet of feedlot performance and urinary calculi formation in lambs.


Cefazolin, a new semisynthetic cephalosporin antibiotic. I. Synthesis and chemical properties of cefazolin.


Studies on the effect of free fatty acid on binding of benzyl-penicillin by serum proteins.


Phosphonomycin: isolation from fermentation sources.


Isolation and characterization of a new antibiotic, neopluramycin.


Deoxynybomycin from a streptomyces.

Deoxynybomycin from a streptomyces.


A device for production of aortic insufficiency in intact experimental animals.


The structure and function of ribonuclease T1. 8. Reaction of 2-hydroxy-5-nitrobenzyl bromide with the single tryptophan residue in ribonuclease T1.


The incidence and distrubition of slipped capital femoral epiphysis in Connecticut and Southwestern United States.


Correlation studies between paper chromatographic mobility and the chemical structure of certain bio-organic substances and their significance for identification.


The use of vapour-programmed thin-layer chromatography in the separation and identification of sulphonamides.


The different chromatographic behaviour of high- and low-molecular-weight substances on nitrocellulose membranes.


Sodium chloride and water transport in the descending limb of Henle. The unique membrane characteristics of the thin descending limb of Henle (DLH) play an integral part in the operation of the countercurrent system. We examined these properties in vitro by perfusing isolated thin descending limbs of rabbits. Active transport of NaCl was ruled out by failure to demonstrate either net transport or transmembrane potential difference when perfusing with isosmolal ultrafiltrate of the same rabbit serum as the bath. Transmembrane potential was zero, and net fluid transport was -0.07 +/-0.06 nl mm(-1) min(-1), which also is not significantly different from zero. Passive permeability coefficient for Na(P(Na)) was determined from the disappearance rate of (22)Na from isosmolal perfusion solution. P(Na) was surprisingly low, 1.61 +/-0.27 x 10(-5) cm sec(-1), a figure which is significantly less than P(Na) in the proximal convoluted tubule (PCT). Reflection coefficient for NaCl (sigmaNaCl) was measured by perfusing the tubule with Na-free raffinose solution in a bath of rabbit serum to which sufficient NaCl was added to obtain conditions of zero net fluid movement. The measured sigmaNaCl of 0.96 +/-0.01 is significantly greater than sigmaNaCl in the PCT. Water permeability to osmotic gradients (L(p)) was determined by perfusing with ultrafiltrate of rabbit serum in a bath made hyperosmotic by addition of either 100 mOsm raffinose or NaCl. L(p) with raffinose was 1.71 +/-0.15 x 10(-4) ml cm(-2) sec(-1) atm(-1) and with NaCl 1.62 +/-0.05 x 10(-4) ml cm(-2) sec(-1) atm(-1), indicating much greater water permeability than in the PCT. In each case the measured increase in osmolality of the collected fluid was primarily due to water efflux without significant influx of solute. The finding of low permeability to sodium and high permeability to water is consonant with the hypotheses that high interstitial concentration of Na in the medulla generates an effective osmotic pressure which results in concentration of the fluid as it courses through the DLH primarily by abstraction of water without significant net entry of NaCl.


Correlation of serum follicular stimulating hormone (FSH) and luteinizing hormone (LH) as measured by radioimmunoassay in disorders of sexual development. Serum FSH and LH levels in 104 patients with disorders of sexual development were determined by radioimmunoassay and compared with serum FSH and LH levels in 164 normal individuals.32 of 35 gonadal dysgenesis patients (ages 4.8-18.9 yr) had serum FSH levels which were elevated above the range of normal for chronological age, and 19 had serum LH levels similarly elevated. All patients with elevated serum LH levels were 11 yr of age or older. However, 8 of 10 gonadal dysgenesis patients, ages 4.8-10.9 yr, had serum FSH levels elevated above the normal range. In accord with these observations was the finding that in normal girls, serum FSH levels may increase at an earlier age than do serum LH levels (FSH, 5-8 yr of age; LH, 9-10 yr of age). These data indicate that serum FSH determinations may be helpful in diagnosing gonadal dysgenesis during childhood. Serum gonadotropin levels within the range of normal for chronological age were found in 2 of 18 girls with idiopathic isosexual precocity. The other 16 had serum FSH levels elevated above the range of normal for chronological age, and 8 also had serum LH levels similarly elevated. In all instances serum FSH and LH levels were in the range expected for the stage of sexual development. In 35 boys, ages 13.1-17.8 yr, with delayed adolescence, serum gonadotropin levels correlated with stage of sexual development and, therefore, were often less than those expected for age.8 patients with premature pubarche, 5 patients with premature thelarche, and 3 patients with adolescent gynecomastia had serum gonadotropin levels within the range of normal for chronological age.


Abnormal lipid composition of chylomicrons in broad-beta disease (type 3hyperlipoproteinemia). Chylomicron (primary particles) were detected by polyvinylpyrollidone (PVP) flocculation in plasma collected after an overnight fast from eight hyperlipemic subjects with broad-beta disease (type III hyperlipoproteinemia). The composition of these chylomicrons was abnormal: relatively poor in triglyceride and rich in cholesterol, giving rise to a triglyceride/cholesterol ratio of < 3.0 in all cases, uniformly below the ratio in chylomicrons from eight fasting subjects with mixed lipemia. By contrast, at the peak of alimentary lipemia following an oral fat load (2 g/kg), chylomicrons from broad-beta subjects had normal, triglyceride-rich composition (triglyceride/cholesterol = 14.0) and resembled chylomicrons from subjects with mixed lipemia, endogenous lipemia, and familial hypercholesterolemia after similar fat loads. As the alimentary lipemia cleared, chylomicrons remaining in broad-beta subjects 14-24 hr after the fat load were again rich in cholesterol. However, a similar degree of cholesterol enrichment was observed in chylomicrons from the subjects with familial hypercholesterolemia, while only a minor increase in cholesterol was recorded in chylomicrons from subjects with mixed or endogenous lipemia. Parallel studies of changes in chylomicron composition during in vitro incubation of whole plasma and of S(f) > 400 with S(f) < 400 lipoproteins from subjects with the different forms of hyperlipoproteinemia revealed equal cholesterol enrichment of chylomicrons from a subject with mixed lipemia and from a subject with broad-beta disease in media of equivalent cholesterol content. These experiments suggested neither excessive avidity of chylomicrons for cholesterol uptake nor excessive influence of S(f) < 400 lipoproteins upon chylomicron composition in broad-beta disease.Thus, results in this study suggest that the cholesterol-rich chylomicrons observed in subjects with broad-beta disease after an overnight fast may originate in the intestine as particles of normal composition (chiefly dietary triglyceride) but assume a composition which is relatively rich in cholesterol through processes of lipolysis and cholesterol transfer among circulating lipoproteins which may not be unique to broad-beta disease.


High resolution observations of biological sections with a high voltage electron microscope.


Short-term measurement of catabolic rates using iodine-labeled plasma protein. Fractional catabolic rates of iodine-labeled plasma albumins and fibrinogens have been measured in experiments of a few hours duration in adult rabbits. The method used which is based on release of labeled iodide from the protein gives accurate estimates of catabolic rates (expressed as fractions of the plasma protein pool catabolized per day) after 36 hr without the need for urine collections. At earlier times and using undenatured albumin, fractional catabolic rates increased steadily from approximately 10% per day in the first few hours to a constant 20-25% per day after 24 hr. Fibrinogen values which started at 15% plateaued after 24 hr at 30-35% per day. The fractional synthesis rate of albumin, measured with (14)C-labeled carbonate in the first 6 hr when the short-term fractional catabolic rate was 10.2% agreed with the 36 hr plateau value of 29% per day. The presence of traces of denatured or polymerized proteins was revealed by high initial fractional catabolic rates, and in a few experiments biological screening in another animal was not fully effective in removing them. On the other hand, some labeled albumins showed no traces of denatured protein even without biological screening. Fibrinogen polymer was catabolized rapidly and behaved like denatured or incipiently clotted fibrinogen. Irradiation of albumin produced a marked increase in early fractional catabolic rates, and some proteins after prolonged storage and labeling behaved similarly. Alternative theories to explain the low fractional catabolic rates in the first 24 hr are considered. Since radioautographic experiments failed to provide evidence for retention of labeled proteins or their nondiffusible breakdown products inside catabolic cells, preference is given to the view that catabolism occurs in a pool of significant protein content which is either a subunit of the extravascular pool or is independent and sandwiched between the plasma and extravascular pools. Earlier hypotheses concerning small catabolic pools in which protein specific activities approximate closely to plasma values at the same time are considered to be no longer tenable.


The fine structure of nerve endings in the sinus node of the canine heart.


Glycogen accumulation in astrocytes of the striatum and pallium of the rabbit following administration of psychotropic drugs.


Prismatic adaptation under scotopic and photopic conditions.


Aging and life space in Poland and the United States.


Prevention of meningococcal infections.

Prevention of meningococcal infections.


Clinical pharmacology of carbenicillin compared with other penicillins.


Tissue localization of the heme-hemopexin complex in the rabbit and the rat as studied by light microscopy with the use of radioisotopes.


Peripheral vascular injuries.

Peripheral vascular injuries.


Novel preparation of cardiolipin from beef heart. A new method is described for the isolation of beef heart cardiolipin. A lipid-protein complex, rich in cardiolipin, is obtained by a one-step solvent fractionation of the tissue total lipid extract. Cardiolipin in the complex is largely freed of protein by salt denaturation and is further purified by gel filtration on Sephadex LH-20 followed by column chromatography on bicarbonate-treated silicic acid. The highly purified product is obtained as the sodium salt in a yield of 85-100 mg/100 g of fresh tissue.


Synthesis and positive inotropic effect of strophanthidol 3-bromacetate-19-H3.


Alkylating agents related to 2,2'-biaziridine. 3. The stereoisomeric N,N'-dimethanesulfonyl-2,2'-biaziridines.


Irreversible enzyme inibitiors. CLXXII. Proteolytic enzymes. XVI. Covalent bonding of the sulfonyl fluoride group to serine outside the active site of alpha-chymotrypsin by exo-type active-site directed irreversible inhibitors.


Modification of recovered dominant lethal mutations induced by heteroaromatic aziridines in stored housefly sperm.


Replacement of all tryptophan residues in T4 bacteriophage lysozyme by tyrosine residues.


Metabolism of amino acids in incubated slices of mouse brain.


Rhythmicity of RNA polymerase activity and RNA levels in nuclei of rat cerebral cortex.


Carotid-basilar venous plexus fistulas.

Carotid-basilar venous plexus fistulas.


Continuous facial spasm with tumor of the pons. Case report.


Multiple meningiomas occupying separate neuraxial compartments. Case report.


Cor pulmonale as a complication of ventriculoatrial shunts. Case report.


Absorption by the rat of nonvolatile oxidation products of labeled randomized corn oil.


Effect of dietary Sterculia foetida oil on pink-white discoloration and fatty acid distribution in stored eggs.


Presence of HLA antigens on human reticulocytes as demonstrated by electron microscopy.


Bilirubinemia and fasting.

Bilirubinemia and fasting.


A new day for Jenny.

A new day for Jenny.


Do it Yourself.

Do it Yourself.


T & AVR--Britain's shadow hospitals. And then to Aldershot.


Management training and nurses: cause for concern?


Anorexia nervosa: some in-patient nursing aspects.


Video recordings.

Video recordings.


There is hope for these chilren.

There is hope for these chilren.


Psychiatric nurses' attitudes to treatment in a general hospital.


Double-aspect perception and social interest.


Effects of differential spatial orientation on tactual pattern recognition.


Physical treatment of pectoral transfer and flexorplasty.


Transporation of the injured.

Transporation of the injured.


Treatment of renal abnormalities accompanying shock.


Care of the injured in the emergency department.


Treatment of cold injuries.

Treatment of cold injuries.


Extremity fractures in children. 1. Epiphyseal injuries.


Electric injury.

Electric injury.


Initial care of hand injuries.

Initial care of hand injuries.


Diagnosis and management of hepatic trauma.


Psychiatric changes in the acutely injured.


Treatment of acute myocardial infarction. 4. Other complications and rehabilitation.


Auscultation of the senile heart.

Auscultation of the senile heart.


Community medicine at the University of California, San Diego.


Becoming a team physician.

Becoming a team physician.


How I treat hidradenitis suppurativa.

How I treat hidradenitis suppurativa.


Regional Medical Programs; mountain states.


Dizziness.

Dizziness.


Pitfalls of mass chemical screening. 1.

Pitfalls of mass chemical screening. 1.


Supernumerary right intrathoracic rib.

Supernumerary right intrathoracic rib.


Clinical guides to therapy of shock.

Clinical guides to therapy of shock.


Fluid resuscitation of hemorrhagic shock.


Growth relationship between the foetus and the placenta.


Pyoderma gangrenosum.

Pyoderma gangrenosum.


Influence of 16-alpha-hydroxyprogesterone, 20-alpha-hydroxyprogesterone and 20-beta-hydroxyprogesterone on progesterone activity in a bio-assay.


A psychoanalytic model of attention and learning.


Problems of tuberculosis control in the United Kingdom.


Energy deposition spectra of 14C beta radiation in a uniform medium.


A thermodynamic formulation of radiation dose rate.


Electronic monitoring of nanosecond pulses from a field emission electron source.


X- and gamma-irradiation of dilute solutions of chymotrypsin in atmospheres of air and nitrogen: effects on activity towards various substrates.


Relative biological effectiveness of the 10B(n, alpha)7 Li reaction in HeLa cells.


Effects of x-irradiation on the implanting canine embryo.


Comparison of 60-MeV protons and 300-kVp x-rays for induction of lens opacities in RF mice.


The effect of acute x-irradiation on the cell proliferation kinetics of induced carcinomas and their normal counterpart.


Acute mortality of mice and rats exposed to 14 MeV neutrons.


Radiation effects on death and migration of tumor cells in mice.


Effect of regional shielding on bacterial endocarditis in x-irradiated rats.


Gamma-ray spectrometric method using a lithium-drifted silicon detector to determine the antimony deposits in the lung in vivo.


The handling of ileocolic intussusception in a pediatric medical center.


The disadvantaged. An analysis of factors affecting the counseling relationship.


The rehabilitation process--as viewed from the inside. Remarks addressed to the allied health professions.


Interlaboratory control.

Interlaboratory control.


Obesity in patients with cirrhosis of the liver.


Cell density in lamina propria of the colon. A quantitative method applied to normal subjects and ulcerative colitis patients.


The value of rectal biopsy in the diagnosis of Crohn's disease.


Intestinal villus in experimental lymphatic obstruction. Correlation of light and electron microscopic findings with clinical diseases.


Potentiation of maximal gastric acid response to pentagastrin by subthreshold doses of methacholine in Heidenhain pouch dogs.


The gastric acid secretory response to submaximal and maximal continuous intravenous histamine stimulation in patients with duodenal ulcer.


A comparison between the results of truncal and selective vagotomy in patients with duodenal ulcer.


Effect of secretin on histamine- and pentagastrin-stimulated secretion of acid in man.


Determination of trypsin in duodenal fluid as a test of pancreatic function. A methodological note.


A clinical evaluation of elevated serum and urine amylase.


Bicarbonate and acid secretion in the diagnosis of pancreatic disease.


Prediction of tissue loss in experimental frostbite with radioactive xenon.


Initial clinical evaluation of plasma dialysis.


Experimental toxicity of sodium 2-ethylhexyl sulfate.


In vitro assessment of six new hemodialysis membranes.


Uremic blood cleansing by diafiltration using a hollow fiber ultrafilter.


Automatic fluid replacement and blood pressure control during dialysis.


Peritoneal dialysis and its effects on cerebrospinal fluid composition.


On the epidemiology of influenza. II. Persistence of HI antibody titers after the outbreaks of influenza A and B with respect to the different course of infection.


Synthesis and renewal of proteins in duck anterior hypophysis in organ culture. In cultures of duck anterior pituitaries, the synthesis and renewal of the specific secretory protein prolactin and of total newly synthesized tissue proteins were studied. As concerns prolactin, assay of the tissue and culture media hormone content demonstrates de novo synthesis of prolactin in vitro at a constant rate during at least 2 wk. The prolactin content after 1 wk and after 2 wk of culture is the same and is similar to the initial content. The renewal time of this prolactin can be estimated at 28 or 48 hr. As concerns total proteins, the use of a chase after a short pulse of 5 min in the presence of tritiated L-leucine demonstrated that newly synthesized proteins are excreted into the culture medium from 30 min to 1 hr after the beginning of the chase. Therefore, the synthesis and excretion of proteins are two discontinuous phenomena. The migration rate of the total proteins was slower than that of prolactin, indicating that this hormone does not represent more than about half of the newly synthesized proteins. These conclusions are in good agreement with those based on high resolution radioautographic data previously obtained on the same material.


Regulation of initiation of DNA synthesis in Chinese hamster cells. I. Production of stable, reversible G1-arrested populations in suspension culture. Suspension cultures of Chinese hamster cells (line CHO) were grown to stationary phase (approximately 8-9 x 10(5) cells/ml) in F-10 medium. Cells remained viable (95%) for at least 80 hr in stationary phase, and essentially all of the cells were in G(1) Upon resuspension or dilution with fresh medium, the cells were induced to resume traverse of the life cycle in in synchrony, and the patterns of DNA synthesis and division were similar to those observed in cultures prepared by mitotic selection. Immediately after dilution, the rates of synthesis of RNA and protein increased threefold. This system provides a simple technique for production of large quantities of highly synchronized cells and may ultimately provide information on the biochemical mechanisms regulating cell-cycle traverse.


An appraisal of the use of monoamine oxidase as an enzyme marker for the outer membrane of rat liver mitochondria.


Comparison of infectivity of strains of Trypanosoma cruzi (Chagas, 1909).


Immunoglobulin synthesis and secretion. II. Radioautographic studies of sites of addition of carbohydrate moieties and intracellular transport. The subcellular sites of synthesis and route of intracellular transfer of immunoglobulin G (IgG) have been investigated by electron microscope radioautography with precursors used for the polypeptide chain (leucine-(3)H) and for the carbohydrate moieties (galactose-(3)H and glucosamine-(3)H). For this purpose, plasma cells from a mouse myeloma tumor were labeled with appropriate precursors and the distribution of radioautographic grains was determined at the end of the labeling period and after varying times of incubation in unlabeled medium. The results indicated that the polypeptide backbone is synthesized in a region of the cell occupied by the rough endoplasmic reticulum (RER) and is transported from there to the region of the Golgi complex. Galactose is incorporated in IgG primarily at the level of the Golgi complex, whereas the incorporation of glucosamine appears to take place both in the RER and in the Golgi complex. From the Golgi complex, the completed IgG molecules reach the plasma membrane and are discharged extracellularly. The latter route of transport and the mechanism of discharge are not understood but may be mediated via smooth-surfaced vesicles.


Factors determining response to mannitol in acute renal failure.


Tick-borne viruses of West Pakistan. 3. Dera Ghazi Khan virus, a new agent isolated from Hyalomma dromedarii ticks in the D. G. Khan District of West Pakistan.


Evaluation and treatment of the burned patient.


Fee and charge concepts for the occupational therapist.


Group dynamics of the interdisciplinary team.


Future trends in professional education.


Research in occupational therapy.

Research in occupational therapy.


Occupational therapy in a small town.

Occupational therapy in a small town.


Personality characteristics of three allied health professional groups.


An occupational therapy refresher course.


The male occupational therapist: attitudes and trends.


The neuroradiologist and the ear.

The neuroradiologist and the ear.


Cerebral water and electrolytes. Effect of asphyxia, hypoxia, and hypercapnia.


Histological evaluation of long-term microvascular repair and replacement.


Biosynthesis of echinulin by Aspergillus amstelodami from cyclo-L-alanyl-L-tryptophyl-14C.


Metabolically induced shifts in the translational efficiency of yeast spheroplast polysomes.


U.S.-Japan seminar on experimental carcinoma of the glandular stomach.


Histogenesis of fetal mouse isocortex and hippocampus in reaggregating cell cultures.


Chromosomal control of foot pad development in Sarcophaga bullata. II. Cuticle formation and tanning.


Uterine suppression of biochemical and morphogenetic events in Rana pipiens.


On the formation of a homogeneous zygotic population in Chlamydomonas reinhardtii.


An analysis of melanogenesis in cultured chick embryo spinal ganglia.


Effect of local anesthetics on radiocalcium binding in nerve.


An inheritable abnormal beta-chain in rabbit haemoglobin.


Purification of dihydroporphyrins for specific activity determination by thin-layer chromatography.


Studies on polypeptides. XLV. Structure-function studies in the beta-corticotropin series.


Synthesis and pharmacological properties of 4-decarboxamido-8-arginine-vasopressin and its 1-deamino analog.


Synthesis and positive inotropic effect of strophanthidol 3-bromoacetate-19-H3.


Potential naphthoquinone antimalarials. 2-acylhydrazino-1,4-naphthoquinones.


Reduction of 1-(4-dimethylaminobenzylidene) indene.


Hemodynamics, coronary blood flow, and myocardial metabolism in coronary shock; response of 1-norepinephrine and isoproterenol. Hemodynamics and myocardial metabolism were evaluated in 18 patients in cardiogenic shock following acute myocardial infarction. The response to l-norepinephrine was studied in seven cases and the response to isoproterenol in four cases. Cardiac index (CI) was markedly reduced, averaging 1.35 liters/min per m(2). Mean arterial pressure ranged from 40 to 65 mm Hg while systemic vascular resistance varied widely, averaging 1575 dyne-sec-cm(-5). Coronary blood flow (CBF) was decreased in all but three patients (range 60-95, mean 71 ml/100 g per min). Myocardial oxygen consumption (MV(O2)) was normal or increased ranging from 5.96 to 11.37 ml/100 g per min. Myocardial oxygen extraction was above 70% and coronary sinus oxygen tension was below 22 mm Hg in most of the patients. The detection of the abnormal oxygen pattern in spite of sampling of mixed coronary venous blood indicates the severity of myocardial hypoxia. In 15 studies myocardial lactate production was demonstrated; in the remaining three lactate extraction was below 10%. Excess lactate was present in 12 patients. During l-norepinephrine infusion CI increased insignificantly. Increased arterial pressure was associated in all patients by increases in CBF, averaging 28% (P < 0.01). Myocardial metabolism improved. Increases in MV(O2) mainly paralled increases in CBF. Myocardial lactate production shifted to extraction in three patients and extraction improved in three. During isoproterenol infusion CI increased uniformly, averaging 61%. Mean arterial pressure remained unchanged but diastolic arterial pressure fell. CBF increased in three patients, secondary to decrease in CVR. Myocardial lactate metabolism deteriorated uniformly; lactate production increased or extraction shifted to production. In the acute state of coronary shock the primary therapeutic concern should be directed towards the myocardium and not towards peripheral circulation. Since forward and collateral flow through the severely diseased coronary bed depends mainly on perfusion pressure, l-norepinephrine appears to be superior to isoproterenol; phase-shift balloon pumping may be considered early when pharmacologic therapy is unsuccessful.


Individual or institution: the dilemma of the psychiatric profession. An editorial.


Empathy: a developmental model.

Empathy: a developmental model.


An experimental study of listening between the lines.


The schizophrenic patient and depressive symptomatology.


Hostility conflict in neurotic patients who prematurely terminate drug treatment.


Estimation of the major psychotic disorders by objective test scores.


Increased survival of Swiss mice given sublethal infections of Trichinella spiralis.


Volunteer workers at the Towers Leicester.


SOS children villages.

SOS children villages.


'There's a man on my bed'.

'There's a man on my bed'.


Chemically induced porphyria: prevention by prior treatment with phenobarbital. The excessive induction of hepatic delta-aminolevulinic acid synthetase in rats after the administration of porphyria-inducing compounds is prevented by prior treatment with phenobarbital. Studies in vivo and in vitro indicate that phenobarbital prevents the induction of chemical porphyria by increasing the rate of detoxification of inducers by way of drug-metabolizing enzymes of the hepatic endoplasmic reticulum.


Aortic valve replacement with a pulmonary valve autograft: indications and surgical technique.


Serum glutamic oxalacetic transaminase activity in cholecystitis.


Determination of ventilatory insufficiency by mixed venous carbon dioxide measurement using rebreathing techniques in surgical patients.


In vitro neointima formation in vascular prosthesis lined by velour.


Metabolic and hemodynamic effects of secretin and pancreozymin on the pancreas.


Necrotizing enterocolitis of premature infants.


Intramural hematomas of the alimentary tract in children.


Duplication cyst of the duodenum: case report and discussion.


A simple emergency closed thoracostomy set.


Alterations in the enzymatic activity of plasma of guinea pigs infected with Junín virus.


Absorption and release of hydrocarbons by rubber closures: a source of error in some biological assays.


Sphingolipid hydrolases in brain tissue of patients with generalized gangliodosis.


Preparation and properties of specifically labeled radiochemically stable 3H-bilirubin.


Glucose-free fatty acid interactions in the working heart.


A-B-O incompatibility and haemolytic disease of the newborn.


Conformational changes in rabbit muscle aldolase. Kinetic studies.


Chemical approaches to intermediates of enzyme catalysis.


High incidence of lactase activity deficiency in small bowel of adults in the Naples area.


Initial isolation and partial characterization of ovulation inhibitor(s) from cerebral tissue of cows.


Application of the temperature-jump technique to the study of phospholipid dispersions.


Effects of estradiol on the in vitro incorporation of acetate-1-14C and choline-1,2-14C into the phospholipids of human peripheral arteries.


Computer simulation of granulopoiesis: normal and impaired granulopoiesis.


Polyploidy in malignant melanoma.

Polyploidy in malignant melanoma.


Cytogenetic and immunologic abnormalities related to leukemia.


Protective draping of patients for surgical operations on the chest.


Histangic patterns in seborrheic alopecia.


Clinical value of liver function appraisal by means of 131-I-rose bengal. 3. Comparison of the results of 131-I-rose bengal test and BSP test.


K-series centrifuges. 3. Effect of core taper on particle capture efficiency.


Blue lght and jaundice.

Blue lght and jaundice.


Further suicidal behaviour: the development and validation of predictive scales.


The epidemiology of drug overdosage.

The epidemiology of drug overdosage.


Motivation for addiction to amphetamine and reducing drugs.


Unusual effect of fenfluramine.

Unusual effect of fenfluramine.


Psychological reactions to compensable injury.


Memory-for-designs test: a follow-up study.


An ego psychological approach to psychiatric manifestations in systemic lupus erythematosus.


The Missouri automated mental status examination: development, use and reliability.


The reversible organic psychosyndrome in hypothyroidism.


A dental device for ECT anesthesia.

A dental device for ECT anesthesia.


Oral contraceptives and hypertension.

Oral contraceptives and hypertension.


The eternal triangle.

The eternal triangle.


Diagnosis in renal disease. II.

Diagnosis in renal disease. II.


Heparin sorptivity and blood compatibility of carbon surfaces.


Calculation of penetration factors for point gamma-ray sources off the axis of cylindrical hole collimators.


Exchange transfusion in the treatment of patients with acute hepatitis in coma.


Automatic recording of the rate of packing of erythrocytes in blood by a centrifuge.


Trend in work injuries.

Trend in work injuries.


A profile of hard-core personnel employed in heavy industry.


A pathologist looks at screening.

A pathologist looks at screening.


Women in industry--what can't they do?

Women in industry--what can't they do?


Work adjustment and the adolescent soldier.


Spatial visualization, reading, spelling, and mathematical abilities in second- and third-grade children.


Whole-body measurements on the distribution of mercury-203 in humans after oral intake of methylradiomercury nitrate.


Applicators for remote afterloading technique for optimum pelvic dose distribution in carcinoma of the uterine cervix.


Evaluation of radiation treatment of painful conditions of the locomotor system. A double blind study.


Neonatal necrotizing enterocolitis.

Neonatal necrotizing enterocolitis.


Significance of splenomegaly in patients with hepatic cirrhosis and bleeding esophageal varices.


Alterations in the functional capacity of mitochondria in hemorrhagic shock.


Compartmentation of citric acid cycle metabolism in brain: effect of aminooxyacetic acid, ouabain and Ca2+ on the labelling of glutamate, glutamine, aspartate and gaba by [1-14C]acetate, [U-14C]glutamate and [U-14C]asparate.


A new method for measuring motion of flexor tendon grafts.


Haematological study of a rodent malaria model.


The interaction between magnesium and other neuromuscular blocking agents.


Launderable shearlings.

Launderable shearlings.


O-T-C products for diaper rash and prickly heat.


Photoperiodically significant photoreception in sparrows: is the retina involved? Blind house sparrows (150 birds) and normal ones (199 birds) were subjected to various photoperiodic treatments consisting of cycles of 12 hours light, 12 hours dark and 16 hours light, 8 hours dark at intensities ranging from 20 to 500 lux. The testicular, response of the blind birds was found to be indistinguishable from the response of normal birds under these conditions. The data show that a functional extraretinal photoreceptor exists in this species which is fully capable of mediating the gonadal response to photoperiodic stimuli.


"Psychogenic" death: a reappraisal.

"Psychogenic" death: a reappraisal. Social, economic, and medical variables correlated with "psychogenic" death rates across about 30 countries. However, McClelland's psychological motives of achievement, affiliation, and power, determined for each country by content analysis of children's stories, did not. Status integration correlated positively with homicide and negatively with deaths from suicide and ulcers. Low life expectancy, wealth, economic growth, wine consumption, and zinc (cadmium) consumption correlated with deaths from homicide, suicide, ulcers, cirrhosis and hypertension, respectively.


Effect of estrogen on arterial blood levels of alpha-amino nitrogen.


Study of possible causal mechanism of fatty liver of chronic hypoxic suckling rats.


The low-pressure rocking membrane oxygenator. An infant model.


Lactational performance of rats injected with oxytocin, cortisol-21-acetate, prolactin and growth hormone during prolonged lactation.


Thresholds to preoptic stimulation at varying times in the rat estrous cycle.


Ovarian thresholds to exogenous LH at varying times in the rat estrous cycle.


In vitro induction of specific unresponsiveness of immunologically reactive, normal bone marrow cells. Normal rabbit bone marrow cells have been studied according to their immunological reactivity in vitro. The test system involved stimulation by antigen after the subsequent stimulation into cellular proliferation by measuring the uptake of tritium-labeled thymidine. Specific separation of immunological reactivity was obtained by filtration of cells through antigen-coated bead columns. All experimental evidence supported the view that this separation was due to the existence of preformed antibody molecules on the outer cell surface of the antigen-recognizing cells. The response to antigenic stimulation was shown to be strictly dose related and, using supraoptimal concentrations of one antigen, no increased DNA synthesis was recorded. That this state of unresponsiveness represented a state of immunological paralysis was indicated by the normal response of these cells to stimulation by a second antigen in optimal concentration. Thus both methods, cell separation on antigen-coated columns or induction of specific unresponsiveness by antigen in vitro, can produce a cell population specifically devoid of cells reactive against a given antigen.


In vitro induction of a primary response to the dinitrophenyl determinant. Primary antibody response against the dinitrophenyl group has been elicited in vitro after the stimulation of normal mouse spleen explants with 2,4-dinitrophenyl (DNP)-hemocyanin or alpha-DNP-poly-L-lysine (PLL). Antibodies were detected in the culture medium by the inactivation of DNP-T4 phage. The specificity of the reaction was manifested by the lack of the capacity of the medium to inactivate the unmodified bacteriophage and by the inhibition of the inactivation of DNP-T4 with DNP-lysine.


Prenatal chromosome analysis.

Prenatal chromosome analysis.


Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. II. Relationship of the anti-lymphocytic choriomeningitis immune response to tissue injury in chronic lymphocytic choriomeningitis disease. Tissue injury (chronic disease) associated with persistent LCM infection is apparently caused by the host immune response to the virus. Employing parabiosis or cell transfer from hyperimmune donors to isologous virus carriers, the tissue injury of chronic disease could be initiated and/or intensified. Furthermore, the transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells. The pathogenesis of the nonglomerular tissue injury of chronic LCM disease is apparently at least in part related to the interaction of circulating anti-LCM antibody with viral antigen at the tissue site. Trapping of circulating virus-antibody complexes in the glomerular filter is apparently the major cause of the glomerulonephritis.


Estrogenic potential of estriol. A comparison of estrone, estradiol, and estriol in aqueous and lipoid solvents with bioassay.


A practical method for the assay of phenothiazines in biologic fluids.


Embryonic blood flow patterns and heart development.


Rubella. Does she or doesn't she?

Rubella. Does she or doesn't she?


Chemical suppression of primary and anamnestic maternal immunization of Rh-incompatible pregnancies. An animal model.


Neonatal septicemia.

Neonatal septicemia.


Burr cells: classification and effect of splenectomy.


Motor behavior of small for gestational age newborn infants.


Catalysis of polynucleotides in ionic reactions.


Behavior patterns in chromatin-positive Klinefelter's syndrome of sheep.


Arthrogryposis multiplex congenita: a clinical investigation.


Role of oestrogen in spontaneous ovulation demonstrated by use of an antagonist of oestrogen, ICI 46,474.


The patent umbilical vein in portal hypertension.


Propranolol in the treatment of hyperkinetic heart syndrome, idiopathic hypertrophic subaortic stenosis, and systemic hypertension.


Diagnosis of pregnancy in the bitch with an ultrasonic Doppler instrument.


Canine ocular adenocarcinoma of mammary origin.


Superfetation in a cat.

Superfetation in a cat.


Hoff circulation in equine laminitis.

Hoff circulation in equine laminitis.


Trihalogenomethyl compounds of potential therapeutic interest. IX. Miscellaneous reactions.


Synthesis, configuration, and dehydration of some 1-alkyl- and aralkyl-3-methyl-4-o-tolylpiperidin-4-ols.


Experiments in steroid synthesis: oestrone.


Aza-analogues of pteridine. I. 1,2,4,6,8-penta-azanaphthalene and some methyl, dihydro-, and 5-alkoxy-derivatives.


Cyclisation of unsaturated bases derived by Hofmann degradation of perhydroazepines: a convenient synthesis of aza-steroids from steroidal ketoximes.


Heterocyclic compounds from urea derivatives. XVI. Interaction of carbohydrazide and carbodi-imides.


[Heterocyclic compounds from urea derivatives. XVII. Reactions of l-phenylcarbonohydrazide and l-phenylthiocarbonohydrazide with carbodi-imides].


Some reactions of enamines. II. Some alkylation reactions of the pyrrolidine enamines of 3,4-dihydronaphthalen-l(2H)-one and 6,7,8,9-tetrahydro-benzocyclohepten-5-one.


Studies on the metabolites of Zygosporium masonii. I. Structure of zygosporin A.


SStudies on the metabolites of Zygosporium masonii. II. Structures of zygosporins D, E, F, and G.


The rearrangement of N-(2-bromoallyl)-arylamines to 2-methylindoles.


Reduction of quaternary pteridines and purines by sodium borohydride.


Trihalogenomethyl compounds of potential therapeutic interest. 8. Synthesis of some epoxides, amides, alcohols, and acetylenic amines.


Determination of hemoglobin oxygen saturation in the blood of the human fetus at term. Use of OSM 1 and of the nomogram for the adult.


Comparative ultrastructure of the decidua in pregnancy and pseudopregnancy.


Uterine blood flow during early ovine pregnancy.


EEG, ECG, and acid-base observations during acute fetal hypoxia.


Hypertension and muscular subaortic stenosis.


Progress in radioimmunoassay of gastrin.


Levels of luteinizing hormone in sera and pituitaries of ewes during the estrous cycle and anestrus.


Ultrastructure of the rat exocrine pancreas after long term intake of ethanol.


Prothrombin in factor X deficiency.

Prothrombin in factor X deficiency.


Synthesis of progesterone by the mammary gland of the goat.


Obstacles to the prevention and treatment of cancer: a critical summary of a crucial investigation.


Men in occupational health nursing.

Men in occupational health nursing.


Night shift workers help in diabetic study.


Microcephaly and mental retardation.

Microcephaly and mental retardation.


The histologic effects of dilation and internal urethrotomy on the canine urethra.


Ectopic ureterocele as a cuase of urinary incontinence.


Male intersexuality and damage to the upper urinary tract.


Evaluation and treatment of the suspected drug user in the emergency room.


Revision of the external urinary meatus in girls: a clinical appraisal.


Metabolism of neutral steroids in the human fetus. II. Metabolism of progesterone and pregnenolone in anencephalic monsters after delivery.


Total abdominal irradiation using cobalt 60 moving strip technique.


Immunological properties of human vitamin B 12 binders.


The molecular weight of the Bowman-Birk soybean protease inhibitor.


The effect of acetylation on the stability of collagen fiber.


The primary structure of duck egg-white lysozyme II.


The skin, a first level lymphoid organ?

The skin, a first level lymphoid organ?


The clinical aspects of Rift Valley Fever virus in household pets. II. Susceptibility of the cat.


The clinical aspects of Rift Valley Fever virus in household pets. 3. Pathologic changes in the dog and cat.


Salmonella surveillance--1968.

Salmonella surveillance--1968.


Synaptically mediated potentials elicited by the stimulation of post-ganglionic trunks in the guinea-pig superior cervical ganglion.


Responses of the cerebellar cortex to cutaneous and visceral afferents. I. Fiber responses.


Some ambiguities for research in Senate's drug bill.


Insulin-stimulated glucose uptake by subcellular particles from adipose tissue cells. Microsomal particles prepared from isolated rat adipose cells take up D-glucose more rapidly than L-glucose. The rate of D-glucose uptake, but not that of L-glucose, is stimulated by incubation of the intact cells with insulin at concentrations as low as 10 microunits per milliliter before disruption and preparation of the microsomes.


Toxoplasma gondii: the oocyst, sporozoite, and infection of cultured cells. The infective form of Toxoplasma gondii fouind in cat feces is an oocyst wihich, when sporutlated, resembles that of the genus Isospora in havinig two sporocysts. Sporozoites obtained by artificial excystation of the oocyst are infective for monkey kidney cell cultures. Ultrastructural characteristics of sporozoites resemble those seen previously in proliferative stages of Toxoplasma gondii.


Lateral hypothalamic control of killing: evidence for a cholinoceptive mechanism. In rats that would not ordinarily kill mice, lateral hypothalamic injection of crystalline carbachol, a cholinomimetic, elicited killing. Norepinephrine, amphetamine, serotonin, and sodium salts were ineffective at the same site. Carbachol was ineffective when injected into the medial, dorsal, or ventral hypothalamus. As additional evidence for a cholinoceptive mechanism, neostigmine elicited killing, and, in spontaneous killers, methyl atropine blocked it. The results indicate that the lateral hypothalamus contains a cholinoceptive component of an innate system that activates killing, and anticholinergic treatment can be used as a means of suppressing killing.


A sling operation, using Marlex polypropylene mesh, for treatment of recurrent stress incontinence.


Uterine contractions in spontaneous labor. A quantitative study.


Hepatic rupture in the newborn lamb.

Hepatic rupture in the newborn lamb.


Microassay of diphenylhydantoin. Blood and regional brain concentrations in rats during acute intoxication.


Lumbar cerebrospinal fluid electromanometrics with a minitransducer.


Regional cerebral blood flow in apoplexy without arterial occlusion.


Tuberous sclerosis in a premature infant. Report of a case and review of the literature.


Muscular dystrophy in young girls.

Muscular dystrophy in young girls.


Strokes in women of childbearing age. A population study.


Juvenile GM2-gangliosidosis. Clinical variant of Tay-Sachs disease or a new disease.


Calcium metabolism in atrial tissue during frequency potentiation and paired stimulation.


Analysis of the interval histogram of cortical neurons.


Accurate pressure recording in human uterus.


[Electric monitoring of high risk deliveries].


Influence of extracellular sodium concentration on the depolarization rate of atrial fibres.


Electronic spread of current in monolayers of cultured heart cells.


Influence of extracellular sodium concentration on contractility of the isolated rabbit atrium.


A procedure for electromagnetic flowmetry in an internal mammary artery before and after implantation into the myocardium.


Haemodynamics of atrial septal defects.

Haemodynamics of atrial septal defects.


Functional behaviour of the foramen ovale in the newborn piglet.


Quantitative relation between vagal stimulation and heart interval in rabbits.


Effects of atrial pressure on the rate of neonatal pig hearts.


The effects of hypothermia on the ventilatory response to hypoxia and hypercapnia in dogs.


Automatic PO2-stabilization in spirometry.


Studies on avoidance behaviour with a new automated apparatus.


The postnatal development of the ERG evoked with sinusoidally modulated light in the guinea pig and the rabbit.


Strain-gauge--plethysmography (Whitney) in normal persons at rest and after arterial occlusion (reactive hyperaemia).


The determination of blood PCO2 and PO2 with electrodes in an open cuvette system.


A technic for estimating intramyocardial pressure in acute and chronic experiments.


Variation of efficiency of optokinetic stimulation with pattern luminance.


Active elasticity of the isolated rabbit heart.


The influence of a seasonal rowing training on a number of physiological parameters measured during step-wise work load test.


Heat regulation in birds.

Heat regulation in birds.


Introduction to the microsymposium peripheral circulation.


Physical characteristics of the arterial system.


Measuring methods for peripheral circulation in man during work.


Plethysmography in relation to filtrations and edema.


The blood flow through the human calf during rhythmic exercise.


The relation of tissue pressure to disturbances in muscle blood flow.


Determination of central and peripheral pulse wave velocity of children between 2 and 12 years.


The resistance to blood flow in the gastrocnemius of the dog during sustained and rhythmical isometric and isotonic contractions.


An analysis of the reflex activity in the cervical sympathetic trunk induced by myelinated somatic afferents.


Single unit responses in the cervical sympathetic trunk upon somatic nerve stimulation.


Relationship of starling-blackbird roosts and endemic histoplasmosis.


Histoplasmosis in Florida. I. Report of a case and epidemiologic studies.


Fetal intrauterine transfusion II. Review of indications and management.


Radioimmunoassay of gastrin.

Radioimmunoassay of gastrin.


Mechanism of squalene cyclization. Biosynthesis of fusidic acid from (4R)-[2-14C,43H]mevalonic acid.


The synthesis of (1-deamino,4-L-leucine)-oxytocin and (1-deamino,4-L-isoleucine)-oxytocin and some of their pharmacological properties.


Dietary-atherosclerosis study on deceased persons.


Forced convection roasting at 200 degrees and 300 degrees F.


Holding roast beef by three methods.

Holding roast beef by three methods.


Some ultrastructural effects of insulin, hydrocortisone, and prolactin on mammary gland explants. The effects of insulin, hydrocortisone, and prolactin on the morphology of explants from midpregnant mouse mammary glands were studied. Insulin promotes the formation of daughter cells within the alveolar epithelium which are ultrastructurally indistinguishable from the parent cells. The addition of hydrocortisone to the medium containing insulin brings the daughter cells to a new, intermediate level of ultrastructural development by effecting an extensive increase of the rough endoplasmic reticulum (RER) throughout the cytoplasm and an increase in the lateral paranuclear Golgi apparatus. When prolactin is added to the insulin-hydrocortisone medium, the daughter cells complete their ultrastructural differentiation. There is a translocation of the RER, Golgi apparatus, and nucleus and the appearance of secretory protein granules within the cytoplasm. There is excellent correlation between the ultrastructural appearance of the alveoli and their capacity to synthesize casein.


Lysozyme in epiphyseal cartilage. II. The effect of egg white lysozyme on mouse embryonic femurs in organ cultures. Embryonic mouse femoral cartilage, like the epiphyseal cartilage of the calf scapula, contains large amounts of lysozyme. The addition of egg white lysozyme to organ cultures of embryonic mouse femurs induces unique alterations in the gross and microscopic morphology of the femurs. The sites of these alterations are precisely related to the natural distribution of lysozyme in calf scapula. If the exogenous lysozyme is withdrawn from the culture, the morphological changes disappear, accompanied by a resumption or derepression of growth. The effect on growth is evident only in 17-day embryos. These observations support the idea that lysozyme has a physiological role in cartilage, perhaps related to a regulatory mechanism in bone formation.


A comment on graphic displays of bird sounds and analyses with a new device, the melograph mona.


Early Elephantidae of Africa and a tentative correlation of African plio-pleistocene deposits.


Effect of ALS globulins on amino-acid incorporation by human peripheral lymphocytes.


Effect of early malnutrition on the reaction of adult rats to aversive stimuli.


Electroencephalographic abnormalities in hypercalcemia.


A pedigree study of metachromatic leukodystrophy. Biochemical identification of the carrier state.


Regional cerebral blood flow in apoplexy due to occlusion of the middle cerebral artery.


Pyridoxine dependency and penicillamine.


Nature of occlusions of the middle cerebral artery.


Drug dependence among physicians.

Drug dependence among physicians.


An unusual case of 'haematuria' in an XX/XY hermaphrodite.


Alcohol, amines, and alkaloids: a possible biochemical basis for alcohol addiction. Tetrahydropapaveroline is a benzyltetrahydroisoquinoline alkaloidderivative of the biogenic amine, dopnmine. Alcohol, by way of its primary metabolite, acetaldehyde, competitively inhibits nicotinamide-adenine Sinucleotide-linked aldehyde dehydrogenase and augments the formation of tetrahydropapaveroline in vitro. The limited capacity of brain to oxidize aldehydes may be of pharmacological importance because it facilitates the production of tetrahydropapaveroline in the presence of drugs which inhibit this enzyme.


The economics of intensive livestock production.


The efficacy of T1 strain broth vaccine against contagious bovine pleuropneumonia: in-contact trials carried out six and twelve months after primary vaccination.


Nutrition of the growing-finishing pig.

Nutrition of the growing-finishing pig.


The efficac of nitroxynil in the treatment of naturally-occurring ovine fascioliasis.


Isolation of Pasteurella multocida Carter type E in Tanzania.


The isolation of a strain of influenza A virus from turkeys.


The transient inactivation of trypsin by mild acetylation with N-acetylimidazole.


Evidence that cocoonase and trypsin interact with soybean trypsin inhibitor at the same reactive site.


Teen-age patients.

Teen-age patients.


Immune reactions to Nippostrongylus brasiliensis in the rat. I. Characteristics of primary and secondary immune response in vivo.


Training psychiatrists from developing nations.


Clinical cancer chemotherapy aimed at potential cell regulators.


A rapid system for preparative electrophoresis depending on isoelectric buffers of low conductivity.


The formation of short fibres from native cellulose by components of Trichoderma koningii cellulase. Cellulolytic enzyme components of culture filtrates of Trichoderma koningii were fractionated on ionic and non-ionic forms of Sephadex and on cellulose powder (Whatman) and examined for their ability to hydrolyse soluble carboxymethyl-cellulose, and to saccharify, solubilize and form short fibres from native undegraded cellulose of the type found in cotton. DEAE-Sephadex provided two CM-cellulase components and a C(1) component; the C(1) component acted weakly and solely on cotton, forming soluble products but not short fibres. The ability to form short fibres was confined almost wholly to one of the CM-cellulase components which completely degraded cotton, minimally to soluble products and extensively to short fibres. The latter action was unaffected by the presence of the other two components. The two CM-cellulase components solubilized cellulose synergistically whereas the short-fibre-forming component and C(1) component were inhibitory.


Of balloons and biological statistics.

Of balloons and biological statistics.


Choriocarcinoma in a postmenopausal nulligravida.


Drugs that inhibit lactation.

Drugs that inhibit lactation.


The development of lymphoid and haemopoietic tissues in pig fetuses.


Spontaneous thyroiditis in the obese strain of chickens. IV. The effect of thymectomy and thymo-bursectomy on the development of the disease.


The stability of cysteine and cystine during acid hydrolysis of proteins and peptides.


The role of ribonucleic acid and protein synthesis in microsomal aryl hydrocarbon hydroxylase induction in cell culture. The independence of transcription and translation.


Product inhibition of the hexokinases.

Product inhibition of the hexokinases.


Physicochemical characterization of citrate synthase and its subunits.


A phytotoxic glycopeptide from potato plants infected with Corynebacterium sepedonicum.


Mass treatment of ringworm in cattle with griseofluvin mycelium.


Some aspects of feline dermatoses.

Some aspects of feline dermatoses.


Yersinia enterocolitica infection in the bush-baby (Galago).


Present and future veterinary work concerning meat production.


The abused child and the school system.

The abused child and the school system.


Lincomycin in enzootic pneumonia of pigs.


Health observation in action.

Health observation in action.


Chronic disease morbidity and income level in an employed population.


Foodborne disease surveillance in the United States, 1966 and 1967.


The turbidity of public swimming pool waters.


Report of the chairman of the executive board of the American Public Health Association to the Governing Council, 1969.


The Technical Development Board. Report of the chairman to the Governing Council, 1969.


Public health and the law. Suicide: civil right or punishable crime?


The role of the American Public Health Association in the development of comprehensive health services.


A new year and a new course for APHA.

A new year and a new course for APHA.


Utilization of available "nurse power" in Public Health.


The city and the changing American health system.


New health careers for the poor.

New health careers for the poor.


Parsimony applied.

Parsimony applied.


Community care services for the mentally retarded in Britain.


Planning and implementing a large-scale family planning program in Georgia.


Reserving a womb: case for the small family.


Child-rearing attitudes of teen-age Negro girls.


Extragenital choriocarcinoma in a female presenting as a gastric tumour.


Lipogranuloma of the breast due to phenothiazine therapy.


Reduction of incidence of prematurity by folic acid supplementation in pregnancy. Folic acid administered to pregnant Bantu, whose diet is low in folate, was associated with a significant reduction in the incidence of prematurity. No such effect could be demonstrated in White patients subsisting on an average Western diet. This suggests that folate deficiency may contribute to the "pregnancy wastage" in populations whose dietary folate intake is low, and is a further indication for folic acid supplementation during pregnancy in these groups.


Multiple impairment of glycolysis in Veillonella alcalescens. The property of glucose nonfermentation, characteristic of the genus Veillonella, was investigated in V. alcalescens C1, a strain of sheep rumen origin. Cell-free extracts as well as intact cells were incapable of glucose fermentation, thereby eliminating the possibility of nonpermeation. Assimilation of (14)C-glucose was not detectable. Of the 10 glycolytic enzymes, hexokinase, phosphoglyceromutase, and pyruvate kinase were not detectable. The other glycolytic enzymes were present.


Familial cardiomyopathy: a clinical, hemodynamic and angiographic study in one family.


Renal effects of calcitonin.

Renal effects of calcitonin. Porcine calcitonin in a slow-release gelatin vehicle was given by intramuscular injection to 10 patients-four with primary hyperparathyroidism, four with Paget's disease, and two with carcinoma of the breast and hypercalcaemia. All cases showed a fall in serum calcium with an immediate rise in urine calcium. All except three patients with primary hyperparathyroidism showed a fall in serum phosphorus, but an immediate rise in urine phosphorus occurred in all cases. Urine hydroxyproline output fell in three patients with severe Paget's disease. Urine sodium rose in all cases, but the effects on potassium, magnesium, water, and pH were not appreciably different from results obtained in four control subjects who were given the gelatin vehicle alone.The data suggest that calcitonin caused a decrease in the tubular resorption of calcium and phosphorus. The hypocalcaemic effect appeared to be due to a decrease in bone resorption in the patients with Paget's disease but in the remaining cases could be accounted for in part or entirely by the rise in urine calcium.


The fine structure of spermatid-associated, extracellular tubules in the schizopod Mysis oculata relicta.


Ultrastructural changes during spherule formation in Physarum polycephalum.


Gigantopithecus and the origins of Hominidae.


Doctor-patient communication with the inner-city adolescent.


The normal infant.

The normal infant.


Altered dihydrofolate reductase associated with drug-resistance transfer between rodent plasmodia. Resistance to pyrimethamine in strains of Plasmodium vinckei and of Plasmodium berghei is attributed to changes in amounts and properties of the dihydrofolate reductases. The resistant strain of Plasmodium berghei was isolated from an experimentally induced mixed infection of drug-resistant Plasmodium vinckei and drug-sensitive Plasmodium berghei, through biological filtration in hamsters. The drug resistance in Plasmodium berghei appears to have been acquired through transfer of part of the gene or genes coding for dihydrofolate reductase from the resistant Plasmodium vinckei to the sensitive Plasmodium berghei.


Deceptions in the illicit drug market.

Deceptions in the illicit drug market.


A compact apparatus for liquid emulsion autoradiography in total darkness.


The Northumberland Committee report. 2. Conclusions and recommendations.


An agent possibly associated with swine dysentery.


Vaccination of cattle with killed 45-20 adjuvant vaccine. Effects on serological and Milk Ring Tests when used in cattle previously exposed to infection or vaccinated with S.19.


Pyrimidine reactions. XX. Thermal rearrangement of 5-(p-substituted phenyl)-2(and 4)-methoxypyrimidines.


N-acetyl-N-trichloromethylsulphenylarenesulphonamides.


The development of the nucleolus of the ovarian nurse cell of Drosophila melanogaster.


The Dimroth rearrangement. XII. Transformation by alkali of 4-amino-3-benzyl-1,2,3-triazole and its 5-substituted derivatives into the corresponding 4-benzylamino isomers. Retrogression of this reaction in neutral solvents.


Microbiological hydroxylation of steroids. 1. Proton magnetic resonance spectra of ketones, alcohols, and acetates in the androstane, pregnane, and oestrane series.


Reduction of benzyl sulphonyl (sulphone) intermediates to sulphinic acids. Synthesis of hypotaurine, and of L-cysteine and L-homocysteine sulphinic acids.


Studies in mycological chemistry. XXIV. Synthesis of ochratoxin A, a metabolite of Aspergillus ochraceus Wilh.


Studies in mycological chemistry. XXV. Experiments directed towards a synthesis of aflatoxin-G2: synthesis of the coumarino-lactone system.


Oxidative cyclisation of ketone thiosemicarbazones. II. Derivatives of phenoxyacetone.


Synthesis of 3-amino-1,2,3,4-tetrahydro-6-hydroxycarbazole, an analogue of 5-hydroxytryptamine.


Chemistry of cephalosporin antibiotics. XVI. Configurational and conformational analysis of deacetoxy-delta-2- and -delta-3-cephalosporins and their corresponding sulphoxide isomers by nuclear magnetic resonance.


Phytotoxic compounds produced by Fusarium equiseti. IV. Fission of trichothecan-3-alpha,4-beta-diols by manganese dioxide.


Phytotoxic compounds produced by Fusarium equiseti. V. Transformation products of 4-beta,15-diacetoxy-3-alpha,7-alpha-dihydroxy-12,13-epoxytrichothec-9-en-8-one and the structures of nivalenol and fusarenone.


Phytotoxic compounds produced by Fusarium equiseti. VI. 4-beta-8-alpha,15-triacetoxy-12,13-epoxytrichothec-9-ene-3-alpha,7-alpha-diol.


Nitrene. VI. Reaction of 6'-nitropapaverine and its analogue with triethyl phosphite.


Configuration and rearrangements of homoproaporphines.


Spinal cord distribution of the somatic innervation of the external urethral sphincter of the cat.


Enterococcal endocarditis. An analysis of 38 patients observed at the New York Hospital-Cornell Medical Center.


Evidence from dielectric studies for the presence of bound water in myelin.