Acute eye injuries.

Acute eye injuries.


Etiologic factors and presenting complaints of 110 laryngetomized patients.


Hearing aids for children with unilateral losses: are they practical?


The role of arsenic in chronic asthma and cancer.


Aural rehabilitation for a population of hearing impaired adults.


Transplantation of superficial temporal artery to revascularize the external auditory canal.


Aneurysmal bone cyst of the maxillary antrum.


Clinical analysis of 62 allergic rhinitis cases.


"Doctor, I've got sinus.

"Doctor, I've got sinus.


Glaucoma in relation to adult cataract surgery--an outline.


Delayed hypersensitivity to merthiolate preservative.


Ophthalmological aspects of blepharoplasty.


A modification of the Hummelsheim operation for external rectus muscle palsy.


Surgery for prevention of angle closure.


Effect of short-term (5-15 days) topical dexamethasone treatment on intraocular pressure.


Residency Program at St. Mary's Hospital Rochester, New York.


Induction of experimental autoimmune aspermatogenesis by immune serum fractions.


Effect of ionizing radiation on the frequency and ultrastructure of mast cells in mouse spleen.


Changes in DNP histones after irradiation and contact with heparin.


The genetic basis of virulence in dermatophytes.


Induction of translocations in mice by TEPA.


Organ localization of intravenously administered HSA I-131 in chickens.


Further evidence of active synthesis of immunoglobulins in precolostral germfree piglets.


A special case of lysogeny in Mycobacterium avium.


Effect of medium composition on the production of lysine by Corynebacterium sp. 9366-H-454.


Antimicrobial agents. VII. Microbial degradation of the antifungal agent 2-chloro-4-nitrophenol (Nitrofungin).


Regulation of biosynthesis of secondary metabolites. XII. AcetylcoA carboxylase in Streptomyces aureofaciens.


Contribution to the morphology of the productive strains of Penicillium chrysogenum Thom from the Wisonsin family.


The effect of humic and fulvic acids on the growth and efficiency of nitrogen fixation of Azotobacter chroococcum.


The distribution of antagonistic actinomycetes of three types of Indian soils.


Management by objectives and its subsystems.


Top management compensation in Catholic-sponsored hospitals.


Religious personnel: a look to the future.


New dimensions in the care of the aging.


The current status of purchasing education.


The changing urban scene.

The changing urban scene.


Development of a teaching hospital.

Development of a teaching hospital.


Licensure and career mobility.

Licensure and career mobility.


Sophisticated radio network successful.

Sophisticated radio network successful.


The triage nurse.

The triage nurse.


Social service staffing patterns.

Social service staffing patterns.


OR systems as seen by a surgeon.

OR systems as seen by a surgeon.


Saving through centralization.

Saving through centralization.


Attractive holiday meals for patients on modified diets.


Wet grinding of disposables.

Wet grinding of disposables.


Methadone maintenance treatment program.


Utilization of nursing personnel.

Utilization of nursing personnel.


Consents: recent developments.

Consents: recent developments.


Interdepartmental communication.

Interdepartmental communication.


The effect of aldosterone and desoxycorticosterone on the sodium appetite of normal and adrenalectomised rats.


A clinical study of 158 cases of amebic liver abscess.


Isolation of Vibrio cholerae from a well water during a small outbreak of cholera.


Value of caloric tests in cases of vertigo.


Congo red test in amyloidosis.

Congo red test in amyloidosis.


Ossification of the upper end of the tibia--age of appearance and age of fusion with diaphysis.


Anemia. 8. Hemolytic anemia. I.

Anemia. 8. Hemolytic anemia. I.


Temporal order in the perception of vowels.


The pattern of stapedial vibration.

The pattern of stapedial vibration.


Transducer for measuring mandibular movements.


Effects of interaural frequency differences on the lateralization function.


Hazardous noise levels in computer labs.


Fixed-scale mechanism of absolute pitch.


Transducer for measuring lip movements during speech.


Audibility of high harmonics in a periodic pulse.


Discrimination of transient signals having identical energy spectra.


Pitch perception of two-frequency stimuli.


In-head localization of acoustic images.


Effects of electric stimulation of the crossed olivocochlear bundle on single auditory-nerve fibers in the cat.


Variations in the effects of electric stimulation of the crossed olivocochlear bundle on cat single auditory-nerve-fiber responses to tone bursts.


Critical band with respect to temporary threshold shift.


Effects of filtering and vowel environment on consonant perception.


Vowel spectra, vowel spaces, and vowel identification.


A method of treating sciatic pain.

A method of treating sciatic pain.


Bacteremic consumptive coagulopathy.

Bacteremic consumptive coagulopathy.


The use of arterial or venous blood in acid base balance.


Services for the mentally retarded evaluation clinic.


Absorption and multiple scattering by biological suspensions.


Reflections on the use of propranolol in angina pectoris.


Adaptation to pattern spatial frequency: effects on visual movement sensitivity in humans.


Effects of surround luminance on perceptual latency.


Range of perceived hues in two-primary projections.


Psychophysical spectral-sensitivity measurements and color-matching data.


Opponent-color-theory treatment of the CIE 1960 (u, v) diagram: chromaticness difference and constant-hue loci.


Exploratory investigation of perceptual color scaling.


Model of retinal receptive fields.

Model of retinal receptive fields.


In vitro product of a ribonucleic acid polymerase induced by influenza virus. The ribonucleic acid (RNA)-dependent RNA polymerase induced in the microsomal fraction of cells infected with influenza virus synthesized a mixture of single-and double-stranded RNA in vitro. The single-stranded RNA sedimented mainly in the 8S region on sucrose density gradients, with a smaller proportion of the RNA sedimenting at 18S. This sedimentation pattern corresponds closely to that of incomplete influenza virus RNA. The double-stranded RNA formed in vitro sedimented at 11S, but molecules which may be replicative intermediate, sedimenting at 14 to 20S, were also detected in the in vitro reaction product. Similar species of RNA were detected in vivo by pulse-labeling infected cells at the time of polymerase harvest, but the proportion of each RNA species was different, most of the RNA being single-stranded and sedimenting in the 18S region. An 11S double-stranded RNA was also synthesized in vivo. Pulse chase analysis of the double-stranded RNA synthesized in vitro showed that most is stable, and only a small proportion turns over during the reaction. A proportion of the RNA formed in vitro could be annealed to RNA formed in infected cells and to RNA extracted from purified virus.


Effect of rifampicin on poxvirus protein synthesis. Poxvirus strains differ with respect to the effect of rifampicin on viral protein synthesis. Rifampicin severely depressed vaccinia-directed protein synthesis but had little effect on the rate of cowpox-directed protein synthesis, including one late virus-induced enzyme. The spectrum of polypeptides synthesized in cowpox-infected cells was similar in the presence or absence of rifampicin except for one significant difference. After removal of rifampicin, viruslike particles assembled to some extent, even when protein synthesis was inhibited by cycloheximide. However, reversal was more extensive if protein synthesis was allowed.


Suspected rape.

Suspected rape.


Legal aspects of nursing services.

Legal aspects of nursing services.


First stage care of maxillofacial trauma.


How a psychiatrist looks at pain.

How a psychiatrist looks at pain.


What we've learned from the Watts health center.


What patients need is a little self-denial.


Bezoars, old and new.

Bezoars, old and new.


A study of 45 patients. Late systolic murmur mid-systolic click syndrome.


Tips on diagnosing the bleeding patient.


Two minutes with diabetes.

Two minutes with diabetes.


How hemorrhage and transfusion affect organ perfusion, oxygen transport and blood volume.


Cardiopulmonary resuscitation 1970.

Cardiopulmonary resuscitation 1970.


C.S. by any other name would function as well.


Care in catheterization can prevent gram-negative urinary infection.


Peer review: the new look in medical accountability.


Unit-of-use packaging is shape of the future.


Do-it-ourself renovation saves forty-two thousand dollars.


P.R. is not all show and tell--it's also look and listen.


Hospital hearings must be fair, but they don't have to be formal.


Items that work together should be bought together.


The method might not work--but it still hasn't been tried.


Report tells how "fastest growing" hospital specialty got that way.


Problem-oriented record begins with patient.


Small digital computer monitors I.C.U. patients.


These patients tell the tube where it hurts.


Survey shows how doctors, nurses and hospitals agree and disagree on health care issues and outlook.


Hospital built for nurses works well for everyone.


Community medicine paths lead hospital into home, school, E.C.F., work places.


Adjacent effect on suppression efficiency. II. Study on ochre and amber mutants of T4 phage lysozyme.


Genetic effects of N-methyl-N'-nitro-N-nitrosoguanidine in Neurospora crassa.


The effect of storage on the frequency of dominant lethals in Drosophila melanogaster.


Induction by UV-light of sectored and non-sectored petite mutants of Saccharomyces cerevisiae.


Studies on the mutagenic action of N-methyl-N'-nitro-N-nitrosoguanidine in Paramecium aurella with emphasis on repair processes.


Heterologous interchange at meiosis in Drosophila. 3. Interchange-mediated nondisjunction.


X-ray-induced recombination in the fourth chromosome of Drosophila melanogaster females. I. Kinetics and brood patterns.


X-ray-induced recombination in the fourth chromosome of Drosophila melanogaster females. II. Segregational properties of recombinant fourth chromosomes.


Coordinate nondisjunction of Y and fourth chromosomes in irradiated compound-X female Drosophila.


Chemically induced mutations observed as mosaics in Drosophila melanogaster.


Effects of paternal x-irradiation on litter size and early postnatal mortality in swine.


Bacteriophage T4 mutants unable to exclude gene 56 of T2 from the progeny of crosses.


On the inhibitory activity of human prostatic fluid on Candida albicans.


Griseofulvin-resistant mutants in dermatophytes. 2. Physiological and genetic studies.


Estrogen therapy in atrophic vaginitis.

Estrogen therapy in atrophic vaginitis.


Head and neck cancer: preoperative radiation.


[In vitro study of the antifungal effect of phenylmercuric borate on 8 types of pathogenic fungi] (Fre].


Adsorption of chlorhexidine acetate onto different filter media during bacteriological filtration.


Politics in physical therapy.

Politics in physical therapy.


The point of death.

The point of death.


Transplant surgery in otolaryngology.

Transplant surgery in otolaryngology.


Torsion of the testis. A plea to general practitioners.


Childhood obesity.

Childhood obesity.


Analgesic nephropathy.

Analgesic nephropathy.


Hypnosis helps reluctant smokers.

Hypnosis helps reluctant smokers.


Fluocinolone in pustular psoriasis of the foot.


Smoking habits of business executives. Doctor variation in reducing cigarette consumption.


The treatment of chronic venous disorder of the leg.


Cellulose gel pads in the control of incontinence of urine in elderly women.


Family medicine in the academic and community settings.


Modern views on physiology. XX. The kidney.


A capsule research review.

A capsule research review.


Never give up. Cerebral palsy as viewed by its victim.


Team work experience for the mentally retarded.


Methods of communications by the deaf. Oral vs. manual vs. oral-manual.


Pulmonary macrophages. Observations of eosinophilic extracytoplasmic processes. A preliminary report.


An approach to anemia.

An approach to anemia.


Modified Sturmdorf amputation of the uterine cervix.


Clinical experience with nordihydroguaiaretic acid--"chaparrel tea" in the treatment of cancer.


Toxemia.

Toxemia.


Pulmonary hemodynamics during experimental air embolism. Evidence of vasoconstriction.


Marine farming.

Marine farming.


Auditory illusions and confusions.

Auditory illusions and confusions.


The silent epidemic: burn injuries in Texas.


Surgical control of population.

Surgical control of population.


Trends in early syphilis.

Trends in early syphilis.


Why do pregnant women die?

Why do pregnant women die?


Obstetric hemorrhage. Frequency, etiology, and prevention of deaths.


Obstetric anesthesia.

Obstetric anesthesia.


Experiences with IUD complications.

Experiences with IUD complications.


Cervical cone, frozen section diagnosis. Review of 210 cases.


Complete office screening for porphyria.


Thymic hyperplasia simulating mediastinal metastasis.


Clinicopathologic conference.

Clinicopathologic conference.


Symposium: the EENT concern in cerebrovascular disease. Management.


Senile entropion and ectropion.

Senile entropion and ectropion.


Current status of homograft tympanic membrane transplants.


Impact resistant lenses and flammable ophthalmic materials.


Address by William B. Walsh, M.D.

Address by William B. Walsh, M.D.


Symposium: the EENT concern in cerebrovascular disease. Neurovascular considerations.


Symposium: the EENT concern in cerebrovascular disease. Ophthalmologic involvement.


Symposium: the EENT concern in cerebrovascular disease. Otolaryngologic considerations.


An "exposure to risk" register.

An "exposure to risk" register.


A proposed trial of heart disease prevention in industry.


Immunisation requirements for international travel.


Keeping fit in world wide business and holiday travel.


Education for the health professions. Technical discussions at the Twenty-third World Health Assembly.


International Education Year: WHO activities.


Teacher training.

Teacher training.


New approaches to medical teaching in Europe.


Looking to the future in Africa. The beginnings of the University Centre for Health Sciences, Yaoundé, Cameroon.


Medical education in Latin America.

Medical education in Latin America.


The supply of medical textbooks in Latin America.


The WHO fellowship programme.

The WHO fellowship programme.


Modern teaching methodology in the training of the health team.


The social sciences in medical education.


The Southwest Center and instructional television.


Instructional television activities at the Midwest Center.


Programmed movies--a supplemental medium for language development.


Distribution ideas for videotape programs.


The potential of television for teaching the deaf.


Television's neglected strenghts.

Television's neglected strenghts.


1970 survey of instructional television in programs for the deaf.


Teacher self-evaluation and behavioral analysis.


Atoms and atomic energy: a science lesson for the high school deaf.


Mathematics practice, drill and attitudes for vocational education.


Videotapes in teacher preparation.

Videotapes in teacher preparation.


"Sesame Street" captioned for the deaf.

"Sesame Street" captioned for the deaf.


Production and characterization of specific antibodies to gastrin with no cross-reactivity with cholecystokinin-pancreozymin.


Hyperparathyroidism and acute postpartum pancreatitis with neonatal tetany in the child.


Concurrence of features of pseudohypoparathyroidism, pseudopseudohypoparathyroidism and basal-cell nevus syndrome.


A case of toxoplasmic lymphadenitis in an adult with a description of the biopsied lymph nodes.


Application of social learning principles to the training of ghetto Blacks.


Planning of research on effectiveness of psychotherapy.


A postdoctoral program in behavior modification: theory and practice.


Utilization of psychologists in positions of responsibility in public mental health programs: a national survey.


A survey of the interest in continuing education among mental health professionals in the Southeastern States.


Stabilizing support of mental health center programs: testimony on community mental health centers amendments of 1969.


APA-approved doctoral programs in clinical and in counseling psychology: 1969.


Internships for doctoral training in clinical and counseling psychology approved by the American Psychological Association.


Race, social status, and criminal arrest.


Societal reaction as an explanation of mental illness: an evaluation.


Seasonal emergence of Culicoides furens (Diptera: Ceratopogonidae) at Vero Beach, Florida.


Dose-response curves for dominant lethal mutations induced in the sperm and oöcytes of screw-worm flies by N,N'-tetramethylenebis (1-aziridinecarboxamide).


A simple device for producing fluctuating temperatures, with an evaluation of the ecological significance of fluctuating temperatures.


Rapid incorporation of wild genotypes of Culex nigripalpus (Diptera: Culicidae) into laboratory-adapted strains.


Geographical variation in Aedes atropalpus (Diptera: Culicidae).


Arizona Medical Association's malpractice insurance plan.


Evidence for a neural influence on the house fly heart.


Our most immediate threat.

Our most immediate threat.


Dope Stop--Teen Involvement.

Dope Stop--Teen Involvement.


The reinforcing properties of a television presented listener.


An introduction to the functional analysis of speech and language.


The use of operant procedures to reduce rates of reading and speaking.


Reinforcement procedures for establishing and maintaining echoic speech by a nonverbal child.


Extending stimulus control of phoneme articulation by operant techniques.


Reinforcement procedures and the increase of functional speech by a brain-injured child.


Control of a pest population.

Control of a pest population.


Deceleration of inappropriate vocal behavior in a hard-of-hearing child.


The implications of a functional approach to speech and hearing research and therapy.


Age distributions.

Age distributions.


A new deterministic model for the interaction between predator and prey.


A stochastic model for the growth of cells in cancer.


The removal method for two and three samples.


Survival of a mutation under mixed positive assortative and random mating. I. One locus, two alleles without dominance.


Sequential decision for a binomial parameter with delayed observations.


On the detection and estimation of linkage between a locus influencing a quantitative character and a marker locus.


Index selection for direct and maternal genetic components of economic traits.


Multi-variate probit analysis.

Multi-variate probit analysis.


A technique of nonparametric multivariate analysis.


A classification problem involving human chromosomes.


Design of experiments to estimate heritability by regression of offspring on selected parents.


Brain damage and personality change after subarachnoid haemorrhage.


Shock, surgery and cerebral asymmetry.

Shock, surgery and cerebral asymmetry.


The validity of some cognitive tests in the diagnosis of dementia.


Social and economic aspects of transsexualism.


Sexual deviants two years after electric aversion.


Psychiatric admissions from North London related to demographic and ecological characteristics.


Affective disorders in Iraq.

Affective disorders in Iraq.


State benefits as a cause of unwillingness to work.


Intravenous chlorimipramine in the treatment of severe depression.


Video-tape recording as an aid to behaviour therapy.


Diazepam in the management of epilepsy.

Diazepam in the management of epilepsy.


Basic psychoanalytic concepts: V. Resistance.


Phenelzine in obsessional neurosis.

Phenelzine in obsessional neurosis.


Concurrence of Turner's syndrome and anorexia nervosa.


Gradual withdrawal of tranquilizers with the help of ascorbic acid.


The clinical distinction between psychotic and neurotic depressions.


The clinical distinction between the affective psychoses and schizophrenia.


The bearing of treatment of the classification of the affective disorders.


Genetic findings and methodological considerations in manic depressive disease.


Fasting blood lipid concentrations in manic-depressive psychosis.


A repertory grid method of studying groups.


The evidence for a birth order factor in schizophrenia.


A measure of therapist-patient understanding.


Folate deficiency in depressive illness.


The classification of depressive illness.


Basic psychoanalytic concepts. VI. Acting out.


Sibship size and mental illness.

Sibship size and mental illness.


The dyad grid: a modification of repertory grid technique.


Depersonalization phenomena in psychiatric patients.


A case of Kleine-Levin syndrome in India.


Sudden religious conversions in temporal lobe epilepsy.


A case of the Kleine-Levin syndrome of long duration.


Age-related correlates of self-derogation: report of childhood experiences.


The medical assessment of mentally retarded children in hospital.


Treatment of aviation phobias by behaviour therapy.


Treatment of compulsive gamblers by electrical aversion.


Subjective and penile plethysmograph responses to aversion therapy for homosexuality: a follow-up study.


Basic psychoanalytic concepts. 8. Special forms of transference.


Methodological problems in psychotherapy research: observations on the Karon-VandenBos study of psychotherapy and drugs in schizophrenia.


Eye-contact and depression: a preliminary report.


Alcoholism: antisocial traits in male alcoholics.


Royal Medico-Psychological Association memorandum on the second Green Paper on the future of the National Health Service.


Migraine and schizophrenia.

Migraine and schizophrenia.


Critical studies of phage typing as an aid for the identification of mycobacteria.


Acquired hemolytic anemia with unusual serological characteristics probably caused by alpha-methyldopa.


Instantaneous lung capillary blood flow in patients with heart disease.


The effect of venous occlusion on capillary size in man.


Venous return disturbances induced by arrhythmias. A transcutaneous, instantaneous, flowmetric study at the site of the jugular vein.


Influence of ventricular ejection on the relationship between central aortic and brachial pressure pulse in man.


The relationship between myocardial blood flow and bradycardia in man.


Experimental study of mitral valve incompetence and mitral valve lesions following papillary muscle inactivation in the dog.


The effect of cardioacceleration by right atrial pacing on myocardial blood flow in normal human subjects.


Arteriovenous potassium changes and ventricular arrhythmias after coronary artery occlusion.


Myocardial metabolism and function during ischaemia: response to 1-noradrenaline.


The effects of circulatory arrest during profound hypothermia upon human myocardial fine structure.


Testing of an improved ultrasound flowmeter: technical description and results of testing in vitro.


Histochemical study of the 'electrolyte-steroid-cardiopathy with necrosis' (ESCN) in rats.


The surface temperature of electromagnetic velocity probes.


The distribution of sister chromatids at mitosis in Chinese hamster cells.


Quantitative autoradiography of heterochromatin replication in Microtus agrestis.


The gregarisation pheromone of locusts.

The gregarisation pheromone of locusts.


A non-doubling DNA series in somatic tissues of the locusts Schistocerca gregaria (Forskål) and Locusta migratoria (Linn.).


Clarification of alleged "cytologically verified" hybrids between a toad and a frog.


The somatic chromosomes of the small Indian mongoose: autoradiographic analysis of an unbalanced translocation heterozygote.


Chromosomes of human endometrial cells. I. In vitro studies from normal tissues of healthy women.


Genetic studies on a minute centric fragment transmitted through three generations.


Replication of the mouse sex chromosomes early in the S period.


A method for the isolation of insulin from single human pancreas.


Plasma insulin and glucose responses of healthy subjects to varying glucose loads during three-hour oral glucose tolerance tests.


Comparison of the 50 and 100 gram oral glucose tolerance test.


Diagnosis of diabetes. The size and nature of carbohydrate load.


Comparison of different methods for the evaluation of the oral glucose tolerance test.


Diabetes in a pair of identical twins.

Diabetes in a pair of identical twins.


Progressive gangrene of an extremity due to mucormycosis in a diabetic patient.


Sex differences in mental health.

Sex differences in mental health.


The influence of certain child-rearing factors upon the development of a structured and salient sense of time.


Genetic fine structure of the albino (al) region of Neurospora crassa.


A search for temperature-sensitive mutants of Ustilago maydis blocked in DNA synthesis.


Genetic and phenotypic relationships between ovulation rate and body weight in the mouse.


Controlling elements in the mouse X-chromosome. II. Location in the linkage map.


On the fixation probability of mutant genes in a subdivided population.


A note on the diffusion approximation for the variance of the number of generations until fixation of a neutral mutant gene.


The reduction of fitness from genetic drift at heterotic loci in small populations.


The calculation of the map length of interchange segments from meiotic configuration frequencies.


Cell number in early embryos from strains of mice selected for large and small body size.


Dynamics of pattern formation.

Dynamics of pattern formation.


Linkage and the elimination of deleterious mutant genes from experimental populations.


Inheritance of the black form of the leopard Panthera pardus.


Linkage of dwarf with obese in the mouse.


Controlling elements and mutable loci in maize: their relationship to bacterial episomes.


Progeny: sperm ratios and segregation-distorter in Drosophila melanogaster.


Behavioural studies in different strains of mice and the problem of heterosis.


Pulmonary haemosiderosis in mitral stenosis.


Use of pulmonary cardiogram in the diagnosis of pulmonary hypertension in mitral valvular disease and in diagnosis of mitral and tricuspid disease.


Intrarenal distribution of diagnostic agents.


Liver and disturbances of carbohydrate metabolism.


Is osteoporosis a nutritional disease?

Is osteoporosis a nutritional disease?


Porphyrias in Bikaner District of Rajasthan.


Poststenotic dilatation in renal arteries: preliminary report.


Extra pyramidal manifestations following phenothiazines therapy. Report of 10 cases with review of Indian literature.


Angiography of mesenteric arterial occlusion.


Bone mineral determination in vitro by radiographic photodensitometry and direct photon absorptiometry.


Selection of optimum cineradiographic frame rate: relation to accuracy of cardiac measurements.


Craniovertebral anomaly with visual field defect.


Louis-Bar syndrome. A review with three personal cases.


Scanning phantom allowing planar and depth responses.


An academic nonradiologist looks at the academic radiologist.


Sports medicine.

Sports medicine.


Hepatic angiography of experimental transplantable tumor.


Capillary basement membrane structure: a comparative study of diabetics and sexual ateliotic dwarfs. A group of 32 sexual ateliotic dwarfs with an isolated deficiency of human growth hormone (HGH) were shown previously to resemble subjects with genetic diabetes mellitus in terms of hyperlipemia, carbohydrate intolerance, and patterns of insulin secretion. 11 of these dwarfs had needle biopsies of the quadriceps femoris carried out and tissue fixed for electron microscopy. Capillary basement membrane thickness was measured and compared with measurements previously obtained in diabetics and normal controls. Measurements were similar in controls and dwarfs (1080 +/-27 A and 1086 +/-90 A, respectively) and significantly less than in diabetics (2403 +/-119 A). Placed in juxtaposition with the absence of retinopathy in dwarfs and the high incidence in the diabetic group (41%), the data support the thesis that these anatomical abnormalities are largely independent of serum lipid and carbohydrate abnormalities. The data are consistent with a supportive, if not causative role of growth hormone in the pathogenesis of these lesions.


Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes. A technique was devised for a more accurate measurement than has been heretofore possible of one of the factors responsible for hyperglycemia in the complex syndrome of diabetes. This factor is termed impedance and represents the tissues' insensitivity or resistance to insulin-mediated glucose uptake. It was measured by use of steady-state exogenous insulin and glucose infusions during a period of pharmacological suppression of endogenous insulin secretion. Endogenous new glucose production was also inhibited. Impedance as calculated is a direct function of steady-state glucose concentrations, since exogenous insulin concentrations were similar in all studies. Two groups of normal weight subjects were studied. One had maturity onset latent diabetes, and the other (matched for age, weight, and per cent adiposity) was normal. Impedance was closely reproducible in the same individual and remained relatively constant during prolonged infusions. The diabetics had average infusion glucose concentrations (and thus impedance) 68% higher than the normal group, and it is of note that their previously measured glucose intolerance differed by a similar degree; that is, the diabetic's intolerance (as defined by mean weighted plasma glucose response after oral glucose) was 52% greater than that of the normal individuals.


Motion of mitral valves in cardiac arrythmias: ultrasonic cardiographic study.


Measurement of blood flow by angiography with increasing rate of injection: experimental study.


Augmentation of albumin but not fibrinogen synthesis by corticosteroids in patients with hepatocellular disease. Simultaneous studies of albumin and fibrinogen metabolism have been conducted using the carbonate-(14)C method before and after a 13 day course of prednisolone in eight patients with hepatocellular disease. Initially six patients were hypoalbuminemic. The mean plasma albumin and fibrinogen concentrations and albumin and fibrinogen synthetic rates were all lower than the corresponding values in a group of control subjects. Prednisolone therapy was associated with significant increases in the plasma concentration and synthetic rate of albumin but changes in the intravascular albumin pools were not significant. It is inferred that a low synthetic rate of albumin in a patient with liver disease does not necessarily represent the maximum capacity of the diseased liver to synthesize this protein. Changes in the plasma concentration, intravascular pool, and synthetic rate of fibrinogen were small and inconsistent. The data are compatible with a selective action of corticosteroids on hepatic protein metabolism and with the existence of different mechanisms for the control of albumin and fibrinogen synthesis.


Evidence for the chylomicron origin of lipids accumulating in diabetic eruptive xanthomas: a correlative lipid biochemical, histochemical, and electron microscopic study. Plasma lipoprotein alterations in nine insulin-dependent diabetics with hyperlipemia have been related to the lipid accumulating in eruptive xanthomas evolving in these patients. Histochemical and electron microscopic examination of xanthomas have been correlated with the lipid analyses in order to obtain additional evidence regarding the lipoprotein origin of lipids accumulating in the lesions. Both analytical and morphologic evidence suggested that circulating chylomicrons significantly contribute to the xanthoma lipids. All the patients had large quantities of circulating triglyceriderich chylomicrons which carried approximately 70% of the triglyceride found in the plasma. The fatty acid pattern of chylomicron and xanthoma triglycerides were similar. Triglyceride constituted the major lipid found in the xanthomas when they were sampled during their eruption. These findings, take in conjunction with histochemical and electron microscopic evidence of chylomicron particles in the dermal capillary walls, support the theory that blood lipoproteins, and particularly chylomicrons, permeated the vascular walls and the triglycerides carried by these lipoproteins apparently accumulated in tissue macrophages and perithelial cells which evolved into foam cells. Initiation of appropriate therapy resulted in clearance of the chylomicronemia and a concomitant resolution of the xanthomas as reflected by a decrease in total xanthoma lipid. Sequential studies of resolving xanthomas in five patients revealed that xanthoma triglyceride was mobilized more rapidly than cholesterol, resulting in a redistribution of the xanthoma lipids, so that the resolving lesions were cholesterol rich. Consistent with this change in lipid composition, correlative electron microscopy revealed loss of amorphous material from many of the foam cell vacuoles.


Opacification of falx and tentorium during cerebral angiography: preliminary report.


Effect of retransfusion after hemorrhagic hypotension on intrarenal distribution of blood flow in dogs. Hemorrhagic hypotension in anesthetized dogs produces a marked decrease of the cortical blood flow, whereas the medullary blood flow is well preserved. These animals were maintained at blood pressures of 50 mm Hg during a 3 hr period after which their blood pressures were restored by the reinfusion of blood or dextran, or both. In the first group of animals, the reinfusion of blood reestablished the blood pressure to control values, but the cortical blood flow was still nonuniformly decreased whereas the medullary blood flow appeared to be increased. In the second group of animals, phenoxybenzamine failed to protect the kidney completely since after blood reinfusion, the same anomalies described for the preceding group were found in 7 out of 10 dogs. The animals of the third group were reinfused with 50% of the shed blood and 10 ml/kg of a 10 g/100 ml solution of low molecular weight dextran. The modifications of the intrarenal distribution of the blood flow were less marked in this group although the blood flow rate of the inner cortex and the outer medulla was always elevated under these conditions. The reinfusion of low molecular weight dextran alone (20 ml/kg of a 10 g/100 ml solution) restored the blood pressure to levels slightly lower than those observed under control conditions but reestablished a normal pattern of intrarenal blood flow. The reinfusion of high molecular weight dextran was inefficient in correcting completely the anomalies of the renal blood flow. Mechanisms such as the increased sympathetic tone, the liberation of angiotensin, and the intravascular cellular aggregation could possibly account for the persisting anomalies of the renal circulation after reinfusion and are discussed.


Diminished synthesis of an alpha chain mutant, hemoglobin I (alpha-16 lys leads to glu). In patients heterozygous for abnormal hemoglobins there is usually less than 50% of the mutant hemoglobin present in peripheral blood. The synthetic rates of alpha-chain mutants compared to alpha(A) have not been reported to date. In this study the production of alpha(A)- and alpha(I)-chains has been measured in peripheral blood and bone marrow of two patients with approximately 30% hemoglobin I, an alpha-chain abnormality (alpha(16 lys --> glu)). The results suggest that the decreased amount of alpha(I) compared to alpha(A) is due solely to diminished biosynthesis of the alpha(I)-chains. The relative rates of synthesis of alpha(I)- and alpha(A)-chains are similar in both nucleated red cells and reticulocytes indicating that no change occurs during erythroid cell maturation which preferentially affects either alpha(I) or alpha(A) production.


Kinetic parameters and renal clearances of plasma adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in man. Kinetic parameters and the renal clearances of plasma adenosine 3',5'-monophosphate (cyclic AMP) and guanosine 3',5'-monophosphate (cyclic GMP) were evaluated in normal subjects using tritium-labeled cyclic nucleotides. Each tracer was administered both by single, rapid intravenous injection and by constant intravenous infusion, and the specific activities of the cyclic nucleotides in plasma and urine were determined. Both cyclic AMP and cyclic GMP were cleared from plasma by glomerular filtration. The kidney was found to add a variable quantity of endogenous cyclic AMP to the tubular urine, amounting to an average of approximately one-third of the total level of cyclic AMP excreted. Plasma was the source of virtually all of the cyclic GMP excreted. Plasma levels of the cyclic nucleotides appeared to be in dynamic steady state. The apparent volumes of distribution of both nucleotides exceeded extracellular fluid volume, averaging 27 and 38% of body weight for cyclic AMP and cyclic GMP, respectively. Plasma production rates ranged from 9 to 17 nmoles/min for cyclic AMP and from 7 to 13 nmoles/min for cyclic GMP. Plasma clearance rates averaged 668 ml/min for cyclic AMP and 855 ml/min for cyclic GMP. Approximately 85% of the elimination of the cyclic nucleotides from the circulation was due to extrarenal clearance.


Effects of glucagon on adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in human plasma and urine. Glucagon, infused intravenously into fasting, well-hydrated, normal men in doses of 25-200 ng/kg per min, induced up to 30-fold increases in both plasma and urinary cyclic AMP. Cyclic GMP levels were unaffected by glucagon. Simultaneous cyclic AMP and inulin clearance studies demonstrated that the glucagon-induced increase in urinary cyclic AMP was entirely due to glomerular filtration of the elevated plasma levels of the nucleotide. The cyclic AMP response to glucagon was not mediated by parathyroid hormone or epinephrine, and trypsintreated glucagon was completely inactive. The perfused rat liver released cyclic AMP into the perfusate in response to glucagon, indicating that the liver is a possible source of the cyclic AMP entering the extracellular fluids in response to glucagon in vivo.


The relationship between the free pool of proline and collagen content in human liver cirrhosis. The free proline, free glutamic acid, and total collagen contents of the livers of cirrhotic and noncirrhotic patients were determined. The amounts of free proline in the sera of the patients were also determined. The results indicated that certain metabolic changes occurred in cirrhotic livers of humans that were similar to the metabolic changes observed previously in CCl(4)-induced cirrhosis in the rat. The amount of free proline was coordinate with the increase in total collagen, and both were inversely related to the amount of free glutamic acid. The average proline concentration in sera of cirrhotic patients was not higher than that of non cirrhotic patients, suggesting that the metabolic alteration noted above is a local event in the liver related to fibrogenesis. These and other results suggest that the pool size of free proline may play a prime role in regulation of collagen biosynthesis in liver cirrhosis.


Glucagon levels and metabolic effects in fasting man. The role of glucagon in the metabolic adaptation to prolonged fasting in man has been examined. Plasma immunoreactive glucagon was determined during 6-wk fasts and during infusion of exogenous glucagon using an assay which minimized nonpancreatic immunoreactivity. Plasma glucagon concentrations rose twofold to a peak on the 3rd day of fasting and then declined thereafter to a level maintained at or above postabsorptive. Insulin concentration declined to a plateau by the 3rd day. Thus a persisting altered relationship of glucagon and insulin concentrations characterized the fasted state. A synergism of low insulin and relative or absolute elevation of glucagon levels is viewed as a hormonal mechanism controlling the rate of hepatic substrate extraction for gluconeogenesis. Glucagon was infused systemically into 4-6 wk fasted subjects at three dose levels. A marked sensitivity of individual plasma free amino acids to the induced elevations of plasma glucagon within the physiologic range was demonstrated. At higher concentrations, equivalent to those present in the portal vein, stimulation of hepatic gluconeogenesis occurred, and the effects on glucose, insulin, and growth hormone levels and on ketone metabolism were induced.


Uniphasic insulin responses to secretin stimulation in man. Secretin-stimulated insulin release was studied in normal subjects. In response to rapid intravenous injections (pulses) of secretin, insulin levels reached a peak between 2 and 5 min and returned to basal levels with 15 min. In contrast to large glucose pulses, increasing secretin pulses did not elicit sustained or prolonged insulin responses. In addition, insulin responses to a pulse and infusion were essentially identical with that of a pulse alone. Increasing secretin pulses given in 1 day were associated with decreasing insulin responses but not when the same pulses of secretin were given over a 2 day period. When time was the sole variable, insulin responses progressively decreased after identical 15-U secretin pulses given every 30 min, but were unchanged when the interval was 105 min. These observations indicate that secretin in contrast to glucose stimulates insulin release which is uniphasic. They suggest that release occurs only from a stored, readily available pool. This insulin pool appears to be relatively small and can be discharged faster than it refills.


Transport of plasma free fatty acids and triglycerides in man: a theoretical analysis. Three different multicompartmental models of free fatty acid (FFA) and very low density lipoprotein triglyceride fatty acid (VLDL-TGFA) transport in man are formulated from plasma FFA and VLDL-TGFA tracee and tracer data collected over a 24 hr interval after the injection of palmitate-(14)C. All modeling and data fitting were performed on a digital computer using the SAAM program. Structural differences in the three models relate to the position of the slowly turning over compartment required to generate the late portion of the plasma VLDL-TGFA tracer data. The positions of this slow compartment are along the hepatic pathway from FFA to VLDL-TGFA (model A) or in the distribution system of VLDL-TGFA (model B) or in the distribution system of FFA (model C). Although all three models are equally consistent with our experimental data and are supported by observations of others, each reveals inconsistency with some data obtained from the literature. Consequently, a combination model of FFA-TGFA transport, incorporating properties of models A, B, and C would be more consistent with all available data. Experiments that would help to determine the quantitative significance of each of the slow compartments in the combination model are suggested. Several other models suggesting recycling of plasma VLDL-TGFA through the plasma FFA pool, kinetic heterogencity of the plasma VLDL-TGFA pool, and contamination of plasma VLDL-TGFA radioactivity with low density lipoprotein (LDL) TGFA radioactivity were tested. The first model does not explain the late portion of the plasma VLDL-TGFA tracer data. The second and third models, while consistent with our tracee and tracer data, have steady-state implications with respect to the extent of kinetic heterogeneity and size of the LDL-TGFA contaminant that make them unlikely. Assumptions underlying other investigator's models of FFA and TGFA transport in man are reviewed within the logical framework of our models. Quantitative differences among the various models are shown by evaluating all of the models with respect to a common set of plasma FFA and VLDL-TGFA data.


Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets. Transport of plasma-free fatty acids (FFA) and of fatty acids in triglycerides of plasma very low density lipoproteins (VLDL-TGFA) was studied in two normal subjects, five patients with type IV hyperlipoproteinemia, and two patients with type I hyperlipoproteinemia. After intravenous pulse-labeling with albumin-bound 1-palmitate-(14)C, specific radioactivity of plasma FFA and VLDL-TGFA were determined at intervals up to 24 hr. The results were analyzed using several different multicompartmental models each compatible with the experimental data. Fractional transport of VLDL-TGFA was distinctly lower (no overlap) in the type IV patients than in the control subjects, both on a usual balanced diet (40% of calories from carbohydrate) and on a high-carbohydrate diet (80% of calories). However, net or total transport of VLDL-TGFA in the type IV patients was not clearly distinguishable from that in the control subjects, there being considerable overlap on either diet. The results suggest that in this group of type IV patients the underlying defect leading to the increased pool size of VLDL-TGFA is not overproduction but a relative defect in mechanisms for removal of VLDL-TGFA. Since some of these type IV patients had only a moderate degree of hypertriglyceridemia at the time they were studied, and since it is not established that patients with the type IV phenotype constitute a biochemically homogeneous population, the present results should not be generalized. Four studies were done (in two control subjects and two type IV patients) in which the kinetic parameters in the same individual were determined on the balanced diet and on the high-carbohydrate diet. All subjects showed an increase in VLDL-TGFA pool size. Using two of the models for analysis, all showed an increase in net transport of VLDL-TGFA; using the third model, three of the four studies showed an increase in VLDL-TGFA transport. The results are compatible with the interpretation that the carbohydrate-induced increase in VLDL-TGFA, both in controls and type IV patients, is at least in part due to an increased rate of production of VLDL-TGFA. The magnitude of the increase was approximately the same in controls and patients. Thus, metabolic adjustment to a high-carbohydrate regimen in these type IV patients may not be basically different from that in normal controls; the higher levels of VLDL-TGFA reached may simply be another reflection of a defective removal mechanism. An alternative interpretation, compatible with the data, would involve both a carbohydrate-induced increase in fractional rate of release of VLDL-TGFA from liver to plasma and a decrease in fractional removal of VLDL-TGFA from plasma without increase in net production rate. The simpler hypothesis of a single primary effect on net VLDL-TGFA production from FFA seems more likely.


Increased ureteral back pressure enhances renal tubular sodium reabsorption. Moderate increases of ureteral back pressure usually cause decreases of glomerular filtration rate and even greater decreases of sodium excretion. It has been assumed previously that increased ureteral back pressure does not enhance renal tubular sodium reabsorption directly and that the decreases of sodium excretion are caused by the decreases of glomerular filtration rate. In the experiments reported here, the effect of increased ureteral back pressure on urinary sodium excretion was studied in dogs in which changes of filtration rate were minimized by infusing saline while ureteral back-pressure was increased. When ureteral back pressure was increased on one side by 10-23 cm of water, the inulin clearance of the experimental kidney decreased by only 3-12% in 21 experiments, did not change significantly (+/-2%) in eight experiments, and increased by 3-8% in seven experiments. The sodium excretion of the experimental kidney decreased in all experiments regardless of whether its inulin clearance increased, decreased, or was unchanged from control values. When the inulin clearance of the experimental kidney increased or remained unchanged during increased ureteral back pressure, its reabsorption of sodium increased more than could be accounted for by the increase of filtered sodium. When the inulin clearance of the experimental kidney decreased during increased ureteral back pressure, its reabsorption of sodium decreased less than could be accounted for by the decrease of filtered sodium.Therefore, the effect of increased ureteral back pressure to decrease urinary sodium excretion is caused in part by increased tubular reabsorption of sodium.


Metabolism of arterial plasma estrogens by the splanchnic organs of the dog in vivo. In order to study the splanchnic metabolism of blood-borne estrogens, a constant infusion of estrone-6,7-(3)H was made in a series of dogs, and arteriovenous (A-V) differences at equilibrium were determined for estrone-6,7-(3)H and for its products estradiol-17beta, estrone sulfate, estrone glucosiduronate, and estradiol-17beta glucosiduronate across the splanchnic bed (artery-hepatic vein), the small intestine (artery-superior mesenteric vein), and the spleen (artery-splenic vein). Per cent extractions (100 - [V/A] 100) were calculated. The plasma metabolic clearance rate (MCR) for estrone was measured. Principal findings were as follows: mean MCR was 731 liters/day per m(2), SEM 50. By comparison with estimated hepatic plasma flow and using the observed splanchnic extraction of estrone, 45-71% of estrone metabolism was calculated to be extrasplanchnic. The significant mean per cent extractions were as follows (SEM in parentheses): splanchnic bedestrone 85.9 (1.92), estradiol-17beta 88.11 (3.36), estrone sulfate 27.9 (5.22), estrone glucosiduronate -48.5 (9.33), estradiol-17beta glucosiduronate -33.3 (80.3); small intestine-estrone 45.3 (2.60), estradiol-17beta 46.1 (12.9), estrone glucosiduronate - 30.8 (7.9); spleen-estrone 35 (3.8), estrone glucosiduronate 12 (3.7). These results lead to the following conclusions. Both estrone and estradiol-17beta are nearly completely extracted in one passage through the splanchnic bed. There is net uptake of estrone sulfate and net production of estrone glucosiduronate and of estradiol-17beta glucosiduronate by the splanchnic bed. There is net uptake of estrone and of estradiol-17beta by the intestine, associated with substantial net production of estrone glucosiduronate. There is net uptake of estrone by the spleen and a small but significant net uptake of estrone glucosiduronate.


Effects of increased sodium delivery on distal tubular sodium reabsorption with and without volume expansion in man. The separate effects of volume expansion and of increased delivery of sodium on sodium reabsorption in the diluting segment of the distal nephron were studied in man. In six normal subjects during a sustained water diuresis, sodium delivery to the distal nephron was increased without volume expansion by the administration of acetazolamide. In these subjects, free water clearance rose linearly as a function of urine flow. In five patients with complete, central diabetes insipidus, distal sodium delivery was increased by the infusion of hypertonic saline during a sustained water diuresis. In four of these five patients, changes in free water clearance were also observed during hypertonic saline diuresis in the presence of distal blockade of sodium reabsorption with chlorothiazide. At high rates of distal delivery the following observations were made: (a) free water clearance was lower and fractional sodium excretion higher during saline diuresis compared to acetazolamide diuresis; (b) although free water clearance was moderately reduced by chlorothiazide at low rates of urine flow, there was no difference in free water clearance between saline loading alone and saline plus chlorothiazide at high rates of urine flow; and (c) during saline loading free water clearance rose without evidence of a limit when increased distal delivery was accompanied by spontaneous increases in glomerular filtration rate, but tended toward a limit when glomerular filtration rate remained constant. The data indicate that during acute volume expansion with saline, there is a decrease in the fraction of delivered sodium reabsorbed in the distal nephron when compared to the response of the distal nephron to comparable increases in distal sodium delivery in the absence of volume expansion.


Cerebrovascular response to acute hypocapnic and eucapnic hypoxia in normal man. Alterations in human cerebral blood flow and related blood constituents were studied during exposure to acute hypoxia. Observations were made during serial inhalation of decreasing O(2) concentrations with and without maintenance of normocarbia, during 8 min inhalation of 10% O(2), and after hyperventilation at an arterial P(O2) of about 40 mm Hg. In the range of hypoxemia studied, from normal down to arterial P(O2) of about 40 mm Hg, the magnitude of the cerebral vasodilator response to hypoxia appeared to be largely dependent upon the coexisting arterial CO(2) tension. The mean slope of the increase in cerebral blood flow with decreasing arterial O(2) tension rose more quickly (P < 0.05) when eucapnia was maintained when compared with the slope derived under similar hypoxic conditions without maintenance of eucapnia. When 12 subjects inhaled 10% oxygen, cerebral blood flow rose to more than 135% of control in four whose mean decrease in arterial CO(2) tension was - 2.0 mm Hg. The remaining eight had flows ranging from 97 to 120% of control, and their mean decrease in CO(2) tension was - 5.1 mm Hg. When mean arterial P(O2) was 37 mm Hg, hyperventilation was carried out in 10 subjects. Arterial P(O2) increased insignificantly, arterial P(CO2) declined from 34 to 27 mm Hg (P < 0.05), and cerebral blood flow which had been 143% of control decreased to 109%, a figure not significantly different from control.These data demonstrate the powerful counterbalancing constrictor effects of modest reductions in CO(2) tension on the vasodilator influence of hypoxia represented by arterial P(O2) reductions to about 40 mm Hg. Indeed, mild hyperventilation completely overcame the vasodilator effect provided by an arterial O(2) tension as low as 40 mm Hg. The effects of hypoxia on the control of the cerebral circulation must be analyzed in terms of the effects of any associated changes in CO(2) tension.


Hemoglobin stability: observations on the denaturation of normal and abnormal hemoglobins by oxidant dyes, heat, and alkali. Several unstable mutant hemoglobins have alterations which affect areas of the molecule involved in the attachment of heme to globin. Loss of heme from globin has been demonstrated during the denaturation of some of these unstable mutants. The importance of heme ligands for the stability of hemoglobin was illustrated in the present experiments on the denaturation of several hemoglobins and hemoglobin derivatives by heat, oxidative dyes, and alkali. Heating of normal hemolysates diluted to 4 g of hemoglobin per 100 ml at 50 degrees C for 20 hr in 0.05 M sodium phosphate, pH 7.4, caused precipitation of 23-54% of the hemoglobin. Dialysis against water or dilution of the sample decreased denaturation to 12-20%. Precipitation was decreased to less than 3.5% by the presence of 0.015 M potassium cyanide. Increasing the ionic strength of the medium increased precipitation. Cyanide prevented the formation of inclusion bodies when red cells containing unstable hemoglobin Philly, beta35 tyr --> phe, were incubated with the redox dye new methylene blue. Conversion to methemoglobin increased the rate of alkali denaturation of hemoglobin but the presence of potassium cyanide returned the denaturation rate to that of ferrohemoglobin. The ability of cyanide to decrease heat precipitation of hemoglobin may depend on a dimeric or tetrameric state of the hemoglobin molecule. Purified beta-chains, which exist as tetramers, were stabilized but purified monomeric alpha-chains were not rendered more heat resistant by the ligand. Stabilization of hemoglobin by cyanide required binding of the ligand to only one heme of an alphabeta-dimer. Hemoglobin Gun Hill, an unstable molecule with heme groups present only on the alpha-chains was quite heat stable in the presence of cyanide. The binding of cyanide to the iron atom in methemoglobin is thought to be associated with increased planarity of the heme group and increased stability of the heme-globin complex. The stabilizing effect of cyanide in the above experiments suggests that Heinz body formation, heat precipitation of hemoglobin, and the increased alkali denaturation of methemoglobin depend on changes of heme-globin binding.


Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration. A radioimmunoassay for serum digoxin concentration has been used to study the interrelationships of circulating levels of the drug and various factors in the clinical setting in 48 hospitalized patients with cardiac rhythm disturbances due to digoxin intoxication. 131 patients on maintenance doses of digoxin without toxicity and 48 patients with equivocal evidence of digoxin excess were also studied and compared with the toxic group. Patients with cardiac rhythm disturbances due to digoxin intoxication tended to be older and to have diminished renal function compared with the nontoxic group; body weight, serum potassium concentration, underlying cardiac rhythm, and nature of cardiac disease were not significantly different for the groups as a whole. Despite comparable mean daily digoxin dosages, digoxin intoxicated patients had a mean serum digoxin concentration of 3.7 +/-1.0 (SD) ng/ml, while nontoxic patients had a mean level of 1.4 +/-0.7 ng/ml (P < 0.001), 90% of patients without evidence of toxicity had serum digoxin concentrations of 2.0 ng/ml or less, while 87% of the toxic group had levels above 2.0; the range of overlap between the two groups extended from 1.6 to 3.0 ng/ml. Patients with atrioventricular block as their principal toxic manifestation had a significantly lower mean serum digoxin concentration than those in whom ectopic impulse formation was the chief rhythm disturbance. Patients with equivocal evidence of digoxin excess had received comparable daily maintenance doses of digoxin but had a mean serum concentration of 1.9 +/-0.8 ng/ml, intermediate between those of the nontoxic (P < 0.005) and toxic (P < 0.001) groups. Renal function as judged by mean blood urea nitrogen concentration was also intermediate. The data indicate that knowledge of the serum digoxin concentration, weighed in the clinical context, is useful in the management of patients receiving this drug.


Effects of parathyroid hormone on plasma and urinary adenosine 3',5'-monophosphate in man. The effects of parathyroid hormone (PTH) on plasma and urinary adenosine 3',5'-monophosphate (cyclic AMP) levels were studied in normal subjects. Under basal conditions normal adults have plasma concentrations of cyclic AMP ranging from 10 to 25 nmoles/liter and excrete from 1.5 to 5 mumoles of cyclic AMP per g of urinary creatinine. About one-half to two-thirds of the cyclic AMP excreted in the urine is derived from the plasma by glomerular filtration, and the remainder is produced by the kidney. Renal production of cyclic AMP is partly under the control of PTH. It can be suppressed by infusions of calcium and stimulated by infusions of the calcium chelating agent, EDTA. Infusions of PTH in doses up to 10 mU/kg per min were associated with dose-related increases both in urinary cyclic AMP and phosphate. Infusions of PTH in doses ranging from 20 to 80 mU/kg per min did not lead to any further increase in phosphaturia but did lead to further marked increases in urinary cyclic AMP. A modest increase in plasma cyclic AMP was noted when PTH was infused at 40 mU/kg per min. Anephric patients failed to show appreciable increases in plasma cyclic AMP in response to large doses of PTH but did show expected increases in response to glucagon. Surgical removal of parathyroid adenomas from nine patients with primary hyperparathyroidism was invariably followed by a decrease in urinary cyclic AMP, PTH, in large doses, and calcium infusion produced up to 2-fold increases in the other known naturally occurring cyclic nucleotide, guanosine 3',5'-monophosphate (cyclic GMP).


A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moieties of low density lipoproteins. The plasma low density lipoproteins (LDL) in biliary obstruction are characterized almost exclusively by the presence of the immunochemically distinct lipoprotein families, lipoprotein B (LP-B) and lipoprotein X (LP-X). It is suggested that LP-X, with its uniquely high content of unesterified cholesterol and phospholipid, is primarily responsible for the unusual lipid composition of LDL and the abnormal plasma lipid composition in obstructive jaundice. To show their protein moieties, we isolated LP-X and LP-B from the LDL in plasma obtained from patients with obstructive jaundice. A separation procedure was employed which combines ultracentrifugation, heparin precipitation, and ethanol fractionation. Whereas LP-B was characterized by the presence of apolipoprotein B (ApoB), intact LP-X contained a protein moiety of unique composition consisting of a mixture of albumin (approximately 40%) and the specific apolipoprotein, ApoX (60%). These two protein moieties were separated by preparative ultracentrifugation at d 1.21 g/ml of a solution of partially delipidized LP-X. LP-X thus comprises an albumin-lipoprotein complex in which the masked antigenic site of albumin can be revealed by partial or total delipidization. Apolipoprotein X, the characteristic nonalbumin protein moiety of intact or partially delipidized LP-X, was immunochemically different from ApoA, ApoB, albumin, gamma-globulins, and other serum proteins. The results of analytical ultracentrifugation and the immunochemical and electrophoretic properties of ApoX indicated it to be a complex protein consisting possibly of several nonidentical polypeptides. ApoX was characterized by its amino acid composition, and by serine and threonine as the major N-terminal and alanine as the major C-terminal amino acids. It has been suggested that ApoX is similar to, if not identical with, apolipoprotein C.


The role of ceruloplasmin in iron metabolism. The importance of ceruloplasmin in iron metabolism was studied in swine made hypoceruloplasminemic by copper deprivation. When the plasma ceruloplasmin level fell below 1% of normal, cell-to-plasma iron flow became sufficiently impaired to cause hypoferremia, even though total body iron stores were normal. When ceruloplasmin was administered to such animals, plasma iron increased immediately and continued to rise at a rate proportional to the logarithm of the ceruloplasmin dose. The administration of inorganic copper induced increases in plasma iron only after ceruloplasmin appeared in the circulation. Thus, ceruloplasmin appeared to be essential to the normal movement of iron from cells to plasma. Studies designed to define the mechanism of action of ceruloplasmin were based on the in vitro observation that ceruloplasmin behaves as an enzyme (ferroxidase) that catalyzes oxidation of ferrous iron. Retention of injected ferrous iron in the plasma of ceruloplasmin-deficient swine was significantly less than that of ferric iron, reflecting impaired transferrin iron binding. Rat ceruloplasmin, which has little ferroxidase activity, was much less effective than porcine or human ceruloplasmin in inducing increases in plasma iron. These observations suggest that ceruloplasmin acts by virtue of its ferroxidase activity. Eight patients with Wilson's disease were evaluated in order to investigate iron metabolism in a disorder characterized by reduced ceruloplasmin levels. Evidence of iron deficiency was found in six of these, and in five of the six, plasma ceruloplasmin was less than 5% of normal. In comparison, the two patients without evidence of iron deficiency had ceruloplasmin levels of 11 and 18% of normal. It is suggested that iron deficiency tends to occur in those patients with Wilson's disease who have the severest degrees of hypoceruloplasminemia, possibly because of defective transfer of iron from intestinal mucosal cells to plasma.


Effects of insulin on spontaneous activity during food deprivation.


Hypothalamic hyperphagia: males get just as fat as females.


Studies on steroid fever. II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of man. The pyrogenic properties of some C-19 and C-21 steroids were examined by in vitro incubation of human blood leukocytes with serum-buffer solutions of the steroids and injection of the 18-hr supernatants into rabbits. In previous studies this method demonstrated release of leukocyte endogenous pyrogen by etiocholanolone. With two exceptions, steroids known to cause fever in man, such as 11beta-OH etiocholanolone and 3alpha-hydroxy-5beta-pregnane-20-one were also pyrogenic in vitro. All steroids tested which are nonpyrogenic in man, such as androsterone, 3beta-OH etiocholanolone, and 3alpha, 17alpha-dihydroxy-5beta-pregnan-20-one were also nonpyrogenic in vitro. Solubility in aqueous solution did not correlate with pyrogenic capacity. Inhibition of pyrogen release from human leukocytes in vitro by hydrocortisone and estradiol was demonstrated. Hydrocortisone-treated leukocytes released less pyrogen than did normal leukocytes when stimulated either by etiocholanolone or by phagocytosis of heat-killed staphylococci. On the other hand, estradiol-treated blood leukocytes and mononuclear cells showed significant suppression of pyrogen release when phagocytosis, but not etiocholanolone, was used as the stimulus. When blood cells were incubated with progesterone, greater than normal amounts of pyrogen were released following phagocytosis, and the inhibiting effect of estradiol could be partially reversed. Neither estradiol nor hydrocortisone appeared to act on rabbit leukocytes. These studies indicate that a variety of naturally-occurring steroids may alter pyrogen release from leukocytes. Alterations in steroid balance in man may influence normal temperature regulation and contribute to clinical fevers.


Feeding patterns of normal and ventromedial hypothalamic lesioned male and female rats.


Localization of quinine aversion within the septum, habenula, and interpeduncular nucleus of the rat.


Salt seeking in the adrenalectomized rat with an established sugar preference.


Comparison of the motivational properties of deprivation-induced drinking with drinking elicited by central carbachol stimulation.


Effects of chronic stress and differential environments upon brain weights and biogenic amine levels in rats.


Instrumental control and ulceration in rats.


Conditioned drinking and its failure to extinguish: avoidance, preparedness, or functional autonomy?


Attenuation of a conditioned emotional response via reinforcing intracranial stimulation in rats.


Effects of electric shock, D-amphetamine sulphate, and chlorpromazine on factors of emotionality in inbred mice.


Avoidance learning in neonatal dogs.

Avoidance learning in neonatal dogs.


Cross-modal matching by young children.

Cross-modal matching by young children.


Stimulus generalization in salivary conditioning.


Behavioral contrast and frustration effect in multiple and mixed fixed-interval schedules in ther rat.


Effects of prenatal maternal handling on the maturation of rhythmic processes.


Hypoxia and visually guided behavior in cats: effects of oxygen deprivation on differential brightness thresholds.


Human pituitary follicle-stimulating hormone: distribution, plasma clearance and urinary excretion as determined by radioimmunoassay.


The effect of abnormal maternal plasma calcium levels on the offspring of rats.


The effects of an intra-uterine device on uterine cell division and epithelial morphology during early pregnancy in the mouse.


The effect of low environmental temperature on plasma corticosteroid and glucose concentrations in the newborn calf.


Role of oestrogens and gonadotrophins in perphenazine-induced mammogenesis.


Effects of human pituitary extracts on androgen biosynthesis by human adrenals in vitro.


Effect of hypophysectomy of female rats on the activity of pancreatic elastolytic enzymes and the elastin content of heart, lung and aorta.


The response of plasma sugar, free fatty acids, 11-hydroxycorticosteroids and growth hormone to insulin-induced hypoglycaemia and vasopressin in primary myxoedema.


Genetic variation in adrenal structure: quantitative measurements on the cortex and medulla in hybrid mice.


Changes in the metabolic clearance rate of progesterone in the guinea-pig.


Pituitaries of spayed mice of different strains: cytology and gonadotrophin content.


Follicle-stimulating hormone content of the pituitary glands of intact and ovariectomized mice of different strains.


Plasma protein-bound iodine levels in camels.


Gonadotrophin excretion at puberty.

Gonadotrophin excretion at puberty.


The correlation between urinary oestriol excretion and the oestriol concentration in liquor amnii.


Ribosomes in normal and giant placentae.


Magnitude estimations and category judgments of brightness and brightness intervals: a two-stage interpretation.


Transplacental influence of androgen upon ovulatory mechanisms in the rat.


Test of the TSD model in human eyelid conditioning: a priori probability and payoff manipulations.


Verbal interference with encoding in a perceptual classification task.


Dimensional dominance and continuity theory.


Motivational arousal and task complexity: support for a model of cognitive changes in sensory deprivation.


Effect of instructions on visual orientation.


Operant suppression of electrodermal response rate as a function of punishment schedule.


Visual performance after preadaptation to colored lights.


Maximum capacity for sequential one-bit auditory decisions.


Discrimination of succession in visual masking by retarded and normal children.


Knowledge of alternatives and perception of tachistoscopic stimuli.


Search time in a redundant visual display.


Differential patterns of heart rate and skin resistance during a digit-transformation task.


Form constancy and the perceptual task: a developmental study.


Influence of imaged pictures and sounds on detection of visual and auditory signals.


Heart rate and skin conductance during experimentally induced anxiety: effects of anticipated intensity of noxious stimulation and experience.


Frustration effect and resistance to extinction as a function of percentage of reinforcement.


Identification of forms at brief durations when seen in apparent motion.


Intermodality inconsistency of input and directed attention as determinants of the nature of adaptation.


Haptic and visual perception of proportion.


Cognitive processes in the differential trace conditioning of electrodermal and vasomotor activity.


Effects of free association training, retraining, and information on creativity.


Magnitude estimates of the oculogyral illusion during and following angular acceleration.


Resistance to extinction in GSR conditioning following different numbers of postpeak acquisition trials.


Effects of unconditioned stimulus intensity and schedules of 50 per cent partial reinforcement in human classical eyelid conditioning.


Brightness differences and the perception of figure-ground.


Optional intradimensional and extradimensional shifts in children as a function of age.


Perceptual displacement of a test mark toward the larger of two visual objects.


Effect of bracketing lines on speed of "same"-"different" judgment of two adjacent letters.


Backward and forward masking as a function of stimulus and task parameters.


Effects of temporal delays on the ear asymmetry in dichotic listening.


Chromosomal polymorphism in Drosophila birchii.


Blood cell chimerism and freemartinism in heterosexual bovine quadruplets.


Computer calculation of Wright's inbreeding coefficient by Cruden's method.


An XYY survey in a Negro prison population.


Effect of inbreeding in rabbits. Skeletal variations and malformations.


Gonadal hypoplasia and white coat color in Swedish Highland cattle.


Selection in mice for change in viability of a semilethal genotype at the T locus.


The use of a priori probability in progeny tests for recessive alleles.


Complete linkage in females of Culex tritaeniorhynchus mosquitoes.


Pleiotropic effects of the gene for golden color in rainbow trout.


Linkage relationships of Strong's luxoid gene in the mouse.


Endocrine control of flight muscle histolysis in Dysdercus intermedius.


A general solution to a genetic selection problem involving recessive lethals.


Studies on ecdysone transport in insect haemolymph.


A new hereditary degeneration of the mouse retina.


Genetic basis of leukocyte production in mice.


The control of prophenoloxidase activation in larval haemolymph of Calliphora.


Transfer of amino acids from aminoacyl-tRNA into protein by isolated ribosomes of the house cricket.


Developmental changes of osmotic pressure in the haemolymph of Galleria mellonella.


Canine serum transferrins.

Canine serum transferrins.


Amino acid nitrogen and proteins in the haemolymph of adult desert locusts, Schistocerca gregaria.


Genetic correlation between seine escapability and growth capacity in carp.


The chromosomes and a deviation from parthenogenesis in Aphanostigma piri.


Haploid chicken embryos: evidence for diploid and triploid cell populations.


Xq- Turner's syndrome: reconsideration of hypothesis that Xp- causes somatic features in Turner's syndrome.


Red-spotted eye in the mosquito. An autosomal, conditionally codominant mutant.


Heritability of alcohol preference in laboratory mice and rats.


Severe achondroplasia: demonstration of probable heterogeneity within this clinical syndrome.


Absent IgA and deletions of chromosome 18.


Prevalence of abnormal haemoglobins in pulmonary tuberculosis in three different ethnic groups.


Thalassaemia intermedia: a genetic study in 11 patients.


ABO blood groups, haemoglobin genotypes, and loiasis.


The somatic karyotype of Meriones unguiculatus. A morphologic and autoradiographic study.


Achondroplasia in Holstein-Friesian cattle.


Inheritance of vertebral fusion in the skipper frog.


Genetic factors influencing human serum trehalase activity.


A 46,XX,t(Cp+;Cq-) translocation in a girl with multiple congenital anomalies and in her phenotypically normal father 46,XY,t(Cq+;Cq-).


Trisomy E and T-E fistula.

Trisomy E and T-E fistula.


t(2q-; Dq+) in a mentally retarded female child.


A female with the 48,XXXX karyotype.

A female with the 48,XXXX karyotype.


Median facial cleft associated with ring E chromosome.


Autosomal deletion syndrome 46,XX,18p-: a new case report with absence of IgA in serum.


Marginal mandibulectomy in treatment of carcinoma of the floor of the mouth.


Utricular stimulation and oculomotor reactions.


Saccular stimulation and oculomotor reactions.


Thorium induced carcinoma of the maxillary sinus.


Rhabdomyosarcoma of larynx.

Rhabdomyosarcoma of larynx.


A new mini-corkscrew for bronchoscopic foreign bodies.


The organization of acute intensive care in Denmark.


The design of the intensive care unit, department of anaesthesia, university hospital, Copenhagen.


Drowning and the postimmersion syndrome.


On the components of rabbit lens gamma-crystallin.


Selection for body weight at 8 weeks of age. 7. Blood glutathione.


The use of infrared dichroic absorption spectra in the study of the structure of bovine fibrinogen and fibrin.


Platelet aggregation induced by soluble fibrin monomer complexes.


Regulation of the lactose operon in vitro. II. Repression of transcription of the lactose operon.


Common steps in the repair of alkylation and radiation damage in yeast.


Genetic function correlated with unfolding of lampbrush loops by the Y chromosome in spermatocytes of Drosophila hydei.


Transcriptional origin of RNA in a mitochondrial fraction of yeast and its bearing on the problem of sequence homology between mitochondrial and nuclear DNA.


The effect of cycloheximide upon polyribosome stability in two yeast mutants defective respectively in the initiation of polypeptide chains and in messenger RNA synthesis.


The wrong way to think about gene conversion?


Syntactic maturity in schoolchildren and adults.


Dose-response curve for x-ray-induced translocations in mouse spermatogonia. I. Single doses.


Obstetrical medication and infant outcome: some summary considerations.


Delivery medication and infant outcome: an empirical study.


RBE values of 15-MeV neutrons for recessive lethals and translocations in mature spermatozoa and late spermatids of Drosophila.


Genetic classification of the lethal effects of various agents on heterokaryotic spores of Phycomyces.


Dose-response curve for x-ray-induced translocations in mouse spermatogonia. II. Fractionated doses.


Macromolecular synthesis in irradiated bacteria.


The concept of failure to thrive.

The concept of failure to thrive.


The forty-volume, twenty-year index: some reflections.


Fecal fat and nitrogen in healthy children and in children with malabsorption or maldigestion.


An approach to the estimation of the true number of congenital malformations.


Atypical phenylketonuria in a family with a phenylketonuric mother.


Partial deletion of the long arm of chromosome E-18.


Digitalis tolerance in young puppies.

Digitalis tolerance in young puppies.


Hodgkin's disease in the first decade of life.


The education of foreign medical school graduates.


Care of the critically ill child: the problem of disseminated intravascular coagulation.


Oxygen tension measurements on digital blood in the newborn.


Infectious mononucleosis and Reye's syndrome: a fatal case with studies for Epstein-Barr virus.


A spot test for detection of lead in paint.


Needles for percutaneous renal biopsy in infants and children.


Vascular changes in the mandibular alveolar mucosae of diabetic children.


Utilization of a pediatrician in a community child guidance clinic. I. Low-income community.


The clinical and radiological presentation of blowout fracture of the orbit in children.


Evaluation of routine examinations: is the private practice of pediatrics by the pediatrician ineffective?


Intra-uterine growth.

Intra-uterine growth.


Head circumference growth in North American Negro children.


Diabetes insipidus, chlorpropamide, and hypoglycemia.


New technique of sample preparation for respirometry of filamentous fungi. Various difficulties in the respirometry of filamentous fungi were avoided by using samples of moist mycelium layered thinly on tantalum grids. A variety of measurements is feasible with such preparations and are illustrated with samples of Schizophyllum commune from liquid and solid cultures.


Antimycin A-resistant respiratory pathway in Ustilago maydis and Neurospora sitophila.


Chemical constitution of the host-specific toxin of Helminthosporium carbonum. The host-specific toxin of Helminthosporium carbonum Ullstrup has a molecular formula approximating C(32)H(50)N(6)O(10). The compound has been crystallized and a crystalline hydrochloride derivative has been produced. The molecular weight, as determined by chromatography on Sephadex G-10, is slightly less than 700. The toxin appears to be a cyclic peptide, since, although it does not react with ninhydrin or dinitrofluorobenzene, it yields, on hydrolysis, compounds which react to these reagents. It is unstable in dilute acids, yielding ninhydrin-reacting products. Complete acid hydrolysis yields alanine, proline, and three other ninhydrin-reacting components. The infrared spectrum of the toxin reveals an ester band in addition to amide absorption. Its ultraviolet spectrum reveals the presence of unsaturation in the molecule. The toxin is relatively unstable and loses its specific toxicity. This loss of activity appears to be associated with loss of nitrogen and with decreased solubility in water.


The definition of sarcoidosis.

The definition of sarcoidosis.


Frequency of disordered calcium metabolism in sarcoidosis.


Problems in histological interpretation in sarcoidosis.


Calcium metabolism in sarcoidosis.

Calcium metabolism in sarcoidosis.


The Kveim test in sarcoidosis.

The Kveim test in sarcoidosis.


The Kveim test in leprosy.

The Kveim test in leprosy.


The Kveim test in Crohn's disease.

The Kveim test in Crohn's disease.


The fine structure of sarcoid and tuberculous granulomas.


Ocular sarcoidosis.

Ocular sarcoidosis.


Sarcoidosis in bone.

Sarcoidosis in bone.


Skin changes in sarcoidosis.

Skin changes in sarcoidosis.


Evaluation of the clinical and histological features of paratracheal and hilar gland enlargement.


Identical twins, one presenting as tuberculosis, the other as sarcoidosis.


An attempt to demonstrate a transmissible agent from sarcoid material.


Renal involvement in sarcoidosis.

Renal involvement in sarcoidosis.


The late stages of pulmonary sarcoidosis.


Lactate dehydrogenase pattern of middle ear mucosa.


On the problem of damage to the organ of Corti in manipulations on the conductive apparatus of the ear.


The cholinergic innervation of the human nasal mucosa. A histochemical study.


Fitting of stereo acoustical hearing aids. Indicational and financial problems.


Distortions measured inside the cochlea of the guinea pig.


Bio-electrical phenomena in the peripheral acoustic system.


Epipharynx and its pathology.

Epipharynx and its pathology.


Papillomas in the nose and nasopharynx.

Papillomas in the nose and nasopharynx.


The treatment of some patients with a cerebral prolaps in the ear.


A case of Ewing's sarcoma.

A case of Ewing's sarcoma.


Solitary histoplasmosis of the larynx.

Solitary histoplasmosis of the larynx.


Local antibiotic therapy in maxillary sinusitis.


The phonetogram.

The phonetogram.


A case of Wegener's disease.

A case of Wegener's disease.


Sophisticated life assurance.

Sophisticated life assurance.


What do the practice accounts mean?

What do the practice accounts mean?


Hire purchase and contract hire for the motorist.


The high yield system.

The high yield system.


Planning a consulting-room.

Planning a consulting-room.


Taking the work out of gardening.

Taking the work out of gardening.


An evaluation of the effect of high-dose urography on previously impaired renal and hepatic function in man.


Dissecting aneurysm of the renal artery.


Weight-bearing radiography in osteoarthritis of the knee.


An experimental study of the effect of free pleural fluid on the lung scan.


Brain scans in multiple sclerosis.

Brain scans in multiple sclerosis.


99mTc sulfur colloid macroaggregates. A new lung-scanning agent.


Splenic masses detected by scintillation imaging and contrast tomography.


Advantages of 99mTc pertechnetate for thyroid scanning in patients with decreased radioiodine uptake.


Detection of carotid artery obstruction by intravenous radionuclide angiography.


Roentgenographic study of the human trachea with powdered tantalum.


Forming Teflon catheters during angiography.


Roentgen findings in farmer's lung.

Roentgen findings in farmer's lung.


Small bowel intussusception demonstrated by oral barium.


The acute pulmonary edema of heroin intoxication.


Angiography in reversible colonic ischemia.


Double shielding for radium operations.

Double shielding for radium operations.


Lenticulostriate artery abnormalities. Value of direct serial magnification.


Arteriographic demonstration of spontaneous spinal subarachnoid hemorrhage. Case report.


Bilateral symmetrical pseudarthrosis in a newborn.


Evolution of persistently enlarged parietal foramina.


Unusual manifestations of rheumatoid arthritis.


Aneurysm of left atrium.

Aneurysm of left atrium.


A dose-reducing fluoroscopy system. Dose measurements and clinical evaluation.


Computer dosimetry of partially blocked fields in cobalt teletherapy.


Surgical staging of abdominal involvement in unselected patients with Hodgkin's disease.


Radiation exposure-rate dependence of the immune response in mice.


A simple device for infant warming during radiography.


Another examining board in Nuclear Medicine.


Validity of emphysema mortality data.

Validity of emphysema mortality data.


A changing picture of the treatment of asthmatic patients.


Pollen counts and radio advertising.

Pollen counts and radio advertising.


The effects of acute gamma irradiation on the brine shrimp, Artemia. I. Life spans and male reproductive performance.


The effects of acute gamma irradiation on the brine shrimp, Artemia. II. Female reproductive performance.


Modifications to the Weissenberg rheogoniometer for hemorheological and other biorheological studies.


Influence of load on order-disorder transition in native collagen fibres.


A mathematical model of the flow in the axial plasmatic gaps of the smaller vessels.


A method for determining the viscoelastic properties of bioogical fluids.


A device to regulate low air pressures.

A device to regulate low air pressures.


Criminality among patients with Klinefelter's syndrome and the XYY syndrome.


Family background in prison groups: a comparative study of parental deprivation.


Young offenders' images of self and surroundings: a semantic enquiry.


Themes in a therapeutic community.

Themes in a therapeutic community.


Interpersonal considerations and judgements in a day hospital.


Personality, body build and adrenocortical activity.


Basic psychoanalytic concepts. VII. The negative therapeutic reaction.


Androgen excretion and physique in schizophrenia.


Suicide and primary affective disorders.


Treatment of a case of obsessional neurosis using thought-stopping technique.


The effect of unilateral E.C.T. on schizophrenic delusions and hallucinations.


The prevalence of nail-biting in normal and abnormal populations.


Toxic psychosis caused by radioactive iodine.


Shortcomings of scientific psychiatry.

Shortcomings of scientific psychiatry.


Basic psychoanalytic concepts.

Basic psychoanalytic concepts.


Attempted suicide as language.

Attempted suicide as language.


Yoga and psychoanalysis.

Yoga and psychoanalysis.


Immunological aspects of cancer.

Immunological aspects of cancer.


Are antidiabetic drugs dangerous?

Are antidiabetic drugs dangerous?


Yet another penicillin.

Yet another penicillin.


Accuracy of screening methods for the diagnosis of breast disease. Clinical examination, thermography, and 70-mm. mammography were performed in 891 patients-414 presented to hospital with symptoms of breast disease and 477 were asymptomatic. Comparison of the diagnostic accuracy of these methods showed that neither thermography nor 70-mm. mammography has a useful place as an isolated screening procedure for breast cancer. In fact, we consider such a policy dangerous.


Flucloxacillin, a new isoxazolyl penicillin, compared with oxacillin, cloxacillin, and dicloxacillin. Flucloxacillin, a new isoxazole penicillin, is active against penicillinase-producing strains of Staphylococcus aureus and is well absorbed in man after oral and intramuscular administration. Compared with isoxazole penicillins in current clinical use-namely, oxacillin, cloxacillin, and dicloxacillin-flucloxacillin has proved as active against Gram-positive cocci, including penicillin-resistant staphylococci. The extent of binding of flucloxacillin to the protein of human serum was similar to that of oxacillin and cloxacillin and less than that of dicloxacillin. In man flucloxacillin given orally produced total and free serum levels higher than those obtained with oxacillin and cloxacillin; total serum levels similar to those of dicloxacillin, and free levels greater than those of dicloxacillin. Similarly, after intramuscular injection the free serum levels of flucloxacillin were higher than those of oxacillin, cloxacillin, and dicloxacillin.


Prostatic contribution to normal serum acid phosphatase. Total and tartrate-labile serum acid phosphatase levels were compared in patients with and without prostates, and in 12 patients before and after cystoprostatectomy. Absence of the prostate seems to make no significant difference to the levels of serum acid phosphatase. There is no justification for referring to the tartrate-labile serum acid phosphatase as "prostatic acid phosphatase." A substantial incidence of marginally raised levels of serum acid phosphatase in each group of patients suggests that the upper limit of normal for the total serum acid phosphatase should be taken as 5 K.A.u.


Suppression of ventricular tachyarrhythmias by transvenous intracardiac pacing after acute myocardial infarction. Transvenous intracardiac pacing was carried out on nine patients with recurrent ventricular tachyarrhythmia after drug treatment had failed. In eight patients recurrent Ventricular ectopic activity was suppressed by pacing at a rate above the sinus rate. With this technique the need for D.C. shock and repeated antiarrhythmic drugs can be avoided.


Cancer of the prostate. I.

Cancer of the prostate. I.


L-dopa. I.

L-dopa. I.


Prospects for immunotherapy of cancer: experience in experimental systems.


Immunotherapy of cancer.

Immunotherapy of cancer.


Athletes' deaths.

Athletes' deaths.


Criticism of conventional methods of treating solid tumours in man.


Hyperpyrexia after anaesthesia.

Hyperpyrexia after anaesthesia.


Laparoscopy hazard.

Laparoscopy hazard.


Treatment of shock.

Treatment of shock.


Phenacetin nephropathy.

Phenacetin nephropathy.


Allergy to iprindole (Prondole) with hepatotoxicity.


Retaining device for nasogastric tube.

Retaining device for nasogastric tube.


Thyroid dysfunction.

Thyroid dysfunction.


Patenting micro-organisms.

Patenting micro-organisms.


Complication of hysterotomy.

Complication of hysterotomy.


L-dopa for postencephalitic Parkinsonism.


UV-irradiation induced changes in the uptake of acridine orange in living mouse fibroblasts in vitro.


The molecular structure of nucleohistone (DNH).


Chemical kinetics at the micro level. A laser micro temperature jump apparatus for relaxation studies in micro samples.


A cytochemical study of euchromatin and heterochromatin in roots of Rhoeo discolor.


Histoenzymological and cytophotometric studies on the variations of some enzymatic activities in different cell cycle phases in cultured cells.


Proliferative activity and cytochemical properties of nuclear chromatin related to local cell density of epithelial cells.


DNA, RNA and hemoglobin during erythroblast maturation. A cytophotometric study.


Cell fine structure and function--past and present.


Changes in binding between DNA and arginine residues in histone induced by cell crowding.


The distribution of acid phosphatases and esterases in differentiating roots of Vicia faba.


Studies in lipid histochemistry. I. Criticism of performic and peracetic acid-schiff reactions.


Determination of small amounts of noradrenaline using a fluorescence histochemical method.


Human chromosome fibers. Considerations of DNA-protein packing and of looping patterns.


The ultrastructural distribution of succinic dehydrogenase activity in the supraoptico-neurohypophyseal system of the rat.


A new procedure for the ultrastructural localization of acid phosphatases.


Appearance in the blood plasma and excretion of 35S from three chemical forms of sulfur by lambs.


Marking boar spermatozoa with fluorochromes for evaluating spermatozoan transport within gilts.


Effect of protein and fat levels in complete pelleted diets on the growth of mink kits.


Effects of energy intake and dichlorvos during gestation on reproductive performance of gilts and some chemical characteristics of the offspring.


Influence of site of blood withdrawal and stage of fast on concentrations of plasma free amino acids in the growing pig.


Monte Carlo studies of selection and inbreeding in swine. 3. Gene frequency.


Reproductive performance following long-term treatment with melengestrol acetate.


Influence of time of fast on concentrations of free amino acids in plasma and total amino acids in liver protein of young swine.


Response of 170-day-old prepuberal Poland China Yorkshire and crossbred gilts to unilateral ovariectomy.


Transport and distribution of spermatozoa in the reproductive tract of the cow.


Reproductive performance of ewes in an early-weaning, controlled-breeding program.


Treatment of pregnant ewes with cyclophosphamide.


Effect of energy levels provided ewe lambs post-weaning on their development and subsequent production.


Effect of various mineral elements on in vitro rumen cellulose digestion.


Influence of type and level of grain and diethylstilbestrol on the rumen microbial populations of steers fed all-concentrate diets.


Structure of poly-beta-(p-chlorobenzyl)-L-aspartate: x-ray analysis of the alpha-helix form.


Spontaneous renaturation of newly-synthesized bacteriophage T7 deoxyribonucleic acid.


Properties of rapidly labelled deoxyribonucleic acid fragments isolated from the cytoplasm of primary cultures of embryonic mouse liver cells.


Synthesis and structural investigation of poly(L-alanyl-L-alanyl-glycine).


Position of branch points in replicating lambda DNA.


Non-endospermic hemicellulosic beta-glucans from cereals.


Nerve sheath in Multicotyle purvisi Dawes.


Flagellar rootlet attached to the nuclear envelope.


Metabolic effects related to fungitoxicity of carboxin.


Lipid peroxidation, a result of injury in bean leaves exposed to ozone.


Effects of gramicidin on corn mitochondria. The effects of gramicidin D, S, and J on corn mitochondria respiration and swelling were studied. Only gramicidin D was found to have any pronounced effect on mitochondrial swelling. In buffered KCl gramicidin D produced a rapid, respiration-independent swelling which was not reversed with respiratory inhibitors or substrate exhaustion. The respiration rate of exogenous reduced nicotinamide adenine dinucleotide was stimulated by all three gramicidins, but the effects on malate-pyruvate and succinate respiration depended on the type of gramicidin and the reaction media. The respiration effects of gramicidin D may be due to action at specific sites for each substrate.


Amino acid stimulation of carbon dioxide fixation in cell-free extracts of Chlamydomonas reinhardtii.


L-ascorbic acid biosynthesis in higher plants from L-gulono-1, 4-lactone and L-galactono-1, 4-lactone. Detached bean (Phaseolus vulgaris) and strawberry (Fragaria) fruits fed l-gulono-1,4-lactone or l-galactono-1,4-lactone convert this compound, in part, to l-ascorbic acid. When l-galactono-1,4-lactone is given as a 0.25% solution to detached bean shoots, the ascorbic acid content is tripled in less than 10 hours. l-Gulono-1,4-lactone is only 5 to 10% as effective as its epimer. Experiments with specifically labeled l-gulono-1,4-lactone and l-galactono-1,4-lactone prove that conversion is direct. Ascorbic acid is labeled at the same carbon as its precursor.A method is described for preparation of l-galactono-1,4-lactone-2-(14)C from myo-inositol-2-(14)C. This method can be extended to the preparation of l-ascorbic acid-2-(14)C on the basis of results obtained in the present study.


A nonlinear analysis of the mechanics of accommodation.


Smearing of the retinal image during voluntary saccadic eye movements.


Geometrical illusions and figural after-effects. The distorting and distorted components of illusions.


Dependence of visual suppression on the angular size of voluntary saccadic eye movements.


Temporal and spatial characteristics of visual suppression during voluntary saccadic eye movement.


Antibiotics and ureter. IV. Spiramycin.

Antibiotics and ureter. IV. Spiramycin.


Effects of potassium on rat hippocampus: the dependence of hippocampal evoked and seizure activity on extracellular potassium levels.


Brain serotonin and pituitary-adrenal function in rats of different emotionalities.


Nerve mediated response of the guinea-pig colon in situ: activity of some anticholinergic drugs.


Chronically administered nicotine and the blood pressure of normotensive and renal hypertensive rats.


The structure of anticapsin, a new biologically active metabolite of Streptomyces griseoplanus. 1. Physical and analytical data obtained on crystalline anticapsin indicated the empirical formula C(9)H(13)NO(4). Spectral data (u.v., i.r. and proton magnetic resonance) and formation of l-tyrosine on hydrolysis revealed the functionalities and carbon skeleton of the new epoxy keto amino acid. 2. The optical properties of anticapsin (optical rotatory dispersion and circular dichroism) permitted assignment of absolute configuration to the new metabolite. 3. Treatment of anticapsin with hot methanolic hydrochloric acid followed by acetylation gave C(18)H(19)NO(5), the alpha-alkoxycyclohexenone derivative. Analysis of the nuclear-magnetic-resonance and mass spectra of the latter allowed its structure to be determined and confirmed the assigned structure of anticapsin.