Factors affecting production of the mycotoxin F-2 by Fusarium roseum.


The therapeutic community with chronic patients. II.


Conversion reactions in Klinefelter's syndrome.


Applications of mass spectrometry in the steroid field.


Synthetic cardenolides and related products.


Recent advances in the chemistry of terpenoid tumor inhibitors.


On photochemical transformations of steroids.


New methods of specific fluorination.

New methods of specific fluorination.


Chemistry and control of aflatoxin.

Chemistry and control of aflatoxin.


Pest control: a new industrial revolution.


Pesticide residues in the total environment: reliable detection and determination, mitigation, and legislative control and surveillance programmes.


The public health hazards associated with the non-medical and animal health usage of antimicrobial drugs.


Man's control of water quality.

Man's control of water quality.


The treatment of the air pollution problem within the chemical industry of West Germany.


Perception in the absence of the neocortical commissures.


Color vision and color coding.

Color vision and color coding.


Recognition of visual patterns.

Recognition of visual patterns.


Recovering spatial motor coordination after visual cortex lesions.


The role of selective receptive fields in visual perception.


Morphogenetic problems in space perception.


Perception from the standpoint of psychology.


The distribution of attention in infancy.


Neurophysiological coding for the perception of color.


Some characteristics of perception in the speech mode.


Pain perception.

Pain perception.


The perception of hunger.

The perception of hunger.


Perception of satiety.

Perception of satiety.


Epilepsy and disorders of perception.

Epilepsy and disorders of perception.


Thermography of the spine and sacro-iliac joints in spondylitis.


Lumbar epidural injection for the treatment of chronic sciatica.


The neurological basis of thoracic spinal pain.


Permanent electric polarization and pyroelectric behaviour of the vertebrate skeleton. V. The appendicular skeleton of the vertebrates (excluding man).


Permanent electric polarization and pyroelectric behaviour of the vertebrate skeleton. VI. The appendicular skeleton of man.


The formation of the allantoic placenta in the golden hamster (Mesocricetus auratus).


Important assumptions, extrapolations, and established facts which underlie the use of live rubella virus vaccines.


Dilemmas presented by the attenuated rubella vaccines.


Lithium in the drinking water and atherosclerotic heart death; epidemiologic argument for protective effect.


Rubella immunization: reconsideration of our present policy.


Shigellosis in custodial institutions.

Shigellosis in custodial institutions.


Tick-borne viruses of West Pakistan. I. Isolation and general characteristics.


Tick-borne viruses of West Pakistan. II. Hazara virus, a new agent isolated from Ixodes redikorzevi ticks from the Kaghan Valley, W. Pakistan.


Tick-borne viruses of West Pakistan. IV. Viruses similar to or identical with, Crimean hemorrhagic fever (Congo-Semunya), Wad Medani and Pak Argas 461 isolated from ticks of the Changa Manga Forest, Lahore District, and of Hunza, Gilgit Agency, W. Pakistan.


California encephalitis. Epidemiologic studies in Ohio using a quantitative metabolic inhibition test.


The effect of destruction of the bundle of His or the atrioventricular node on cyclopropane-adrenaline cardiac arrhythmias.


The electrical and mechanical response of rat papillary muscle to paired pulse stimulation.


Influence of cyclohexylamine on the adrenergic cardiopathy.


Influence of energy supply and calcium on the low sodium induced changes in the transmembrane potential and contraction of guinea pig papillary muscle.


The effect of shifts in the dietary amino acid pattern on feed consumption in the chick.


Some effects of ethanol on the toxicity and distribution of barbiturates in rats.


Expression of differentiated function by mammary carcinoma cells in vitro.


Effect of L-asparaginase on DNA synthesis in regenerating liver and in other dividing tissues.


Tumor lipids: identification of sterol ester species in Ehrlich ascites cells.


Gene elimination in carcinogenesis: reinterpretation of the somatic mutation theory.


Effect of steroid hormones on the in vivo incorporation of glycine-2-14C into solid Ehrlich tumor, kidney, and liver.


Incorporation of iododeoxyuridine-125-I into the DNA of L1210 leukemia cells during tumor development.


Carcinoma of the colon and antecedent epithelium.


Selected enzymes of pyrimidine nucleotide metabolism in livers from rate fed alpha-naphthylisothiocyanate.


Nickel carbonyl inhibition of RNA synthesis by a chromatin-RNA polymerase complex from hepatic nuclei.


Joint lethal effects of actinomycin D and radiation in mice.


Polyribosome disaggregation in rat liver following administration of tannic acid.


Time course and dose-response characteristics of aflatoxin B1 effects on rat liver RNA polymerase and ultrastructure.


Studies on the mechanism of skin tumor promotion.


Effect of combination treatment with 5-azacytidine and cytidine on the life-span and spleen and bone marrow cells of leukemic (L1210) and nonleukemic mice.


The cellular proliferation kinetics of animal tumors.


Comparison of tumorigenesis and of long-term development of ovarian autografts on the greater omentum of castrated infantile and mature rats.


Experimental investigations with 1-(morpholinomethyl)-4-phthalimido-piperidindione-2, 6 and drostanolone propionate in dimethylbenz-anthracene-induced tumors of Sprague-Dawley rats.


Tumor production in the glandular stomach and alimentary tract of the rat by N-methyl-N'-nitro-N-nitrosoguanidine.


A study of surface ionogenic groups of different types of normal and leukemic cells.


The dependence of DNA and RNA synthesis on protein synthesis in asparaginase-treated lymphoma cells.


Lithium carbonate treatment in psychiatry.


Uptake and distribution of diphenylthiohydantion (DPTH).


The local anesthetic activity of proadifen HCl (2-diethylaminoethyl-alpha,alpha-diphenylvalerate, HCl).


Use of a fresh water snail (Pila globosa, swainson) heart for the bioassay of 5-hydroxytryptamine.


Decreased thrombus formation in rats after chronic nicotine administration.


The effects of an intravenous infusion of norepinephrine on pulmonary and systemic haemodynamics with and without propranolol pretreatent in dogs.


Preferential utilization of newly synthesized norepinephrine in the brain stem of stressed rats.


Reactivity to norepinephrine and nature of the alpha adrenergic receptor in vascular smooth muscle of a genetically hypertensive rat.


Partial agonists and acetylcholine liberation.


Release of norepinephrine in the central nervous system by theophylline and caffeine.


A simple screening method for antiparkinsonian drugs in mice.


The effect of prolonged lithium treatment on the synthesis rate and turnover of monoamines in brain regions of rats.


Cytoplasmic inclusions resembling nucleoli in sympathetic neurons of adult rats. A distinctive cytoplasmic inclusion consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix was identified in the neurons, but not in the supporting cells, of rat sympathetic ganglia. This ball-like structure, designated "nematosome," measures approximately 0.9 micro and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies carried out with the light microscope suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles. In fine structure and stainability, they bear a resemblance to the fibrous component of the nucleolus. Subsynaptic formations, which are a special feature of some of the synapses in sympathetic ganglia, appear similar to the threadlike elements in the nematosomes. The possibility that these three structures-nucleolus, nematosome, and subsynaptic formation-may be interrelated in origin and function is discussed.


New observations on microbodies. A cytochemical study on CPIB-treated rat liver. The liver of male rats has been studied after CPIB stimulation by using the peroxidase reaction for localizing catalase in hepatic cells. CPIB administration leads to an increase in the number of microbodies, and it is suggested that one mechanism by which microbody proliferation occurs is a process of fragmentation or budding from preexisting microbodies. Reaction product was observed not only within the microbody matrix, but outside the limiting membrane of the microbody and in association with ribosomes of adjacent rough endoplasmic reticulum. This localization of reaction product is interpreted as evidence that catalase after synthesis on rough endoplasmic reticulum may accumulate near microbodies and may be transferred directly into these organelles without traversing the cisternae of the endoplasmic reticulum or Golgi apparatus.


Controlled proteolysis of nascent polypeptides in rat liver cell fractions. II. Location of the polypeptides in rough microsomes. Rough microsomes were incubated in an in vitro amino acid-incorporating system for labeling the nascent polypeptide chains on the membrane-bound ribosomes. Sucrose density gradient analysis showed that ribosomes did not detach from the membranes during incorporation in vitro. Trypsin and chymotrypsin treatment of microsomes at 0 degrees led to the detachment of ribosomes from the membranes; furthermore, trypsin produced the dissociation of released, messenger RNA-free ribosomes into subunits. Electron microscopic observations indicated that the membranes remained as closed vesicles. In contrast to the situation with free polysomes, nascent chains contained in rough microsomes were extensively protected from proteolytic attach. By separating the microsomal membranes from the released subunits after proteolysis, it was found that nascent chains are split into two size classes of fragments when the ribosomes are detached. These were shown by column chromatography on Sephadex G-50 to be: (a) small (39 amino acid residues) ribosome-associated fragments and (b) a mixture of larger membrane-associated fragments excluded from the column. The small fragments correspond to the carboxy-terminal segments which are protected by the large subunits of free polysomes. The larger fragments associated with the microsomal membranes depend for their protection on membrane integrity. These fragments are completely digested if the microsomes are subjected to proteolysis in the presence of detergents. These results indicate that when the nascent polypeptides growing in the large subunits of membrane-bound ribosomes emerge from the ribosomes they enter directly into a close association with the microsomal membrane.


Controlled proteolysis of nascent polypeptides in rat liver cell fractions. I. Location of the polypeptides within ribosomes. Free ribosomes containing nascent polypeptide chains labeled in vitro were submitted to proteolysis at 0 degrees by a mixture of trypsin and chymotrypsin. Sucrose gradient analysis showed that polysome patterns are retained even after 24 hr of proteolysis in the cold, while messenger RNA-free ribosomes (generated progressively during in vitro incorporation) are, within 2 hr, completely dissociated into subunits by trypsin. Although ribosomes and subunits are not extensively degraded into smaller fragments during low temperature proteolysis, changes in the acrylamide gel electrophoresis pattern showed that most ribosomal proteins are accessible to and are partially degraded by the proteases. Ribosome-bound nascent polypeptides are partially resistant to proteolysis at 0 degrees , although they are totally digested at 37 degrees or when the ribosomal subunit structure is disrupted by other means. Radioactivity incorporated into nascent chains during incubation times shorter than 3 min was mostly resistant to digestion at 0 degrees . A larger fraction of the initial radioactivity became degraded in ribosomes which incorporated for longer times. In these ribosomes, the amount of radioactivity which was resistant to proteolysis was constant and independent of the initial value, which reflects the labeled length of the nascent chains. These results suggest that the growing end of the nascent polypeptide is resistant to digestion and is protected from proteolytic attack by the ribosomal structure. A pulse and chase experiment confirmed this suggestion, showing that the protected segment is located at the carboxy-terminal end of the nascent chain. The protected segment was contained in the large ribosomal subunit and had a length of approximately 39 amino acid residues, as estimated by chromatography on Sephadex G-50.


Ultrastructural changes in cells of pea embryo radicles during germination. Radicles (1 mm long) of pea embryo axes, excised from dormant seeds and from seeds soaked for 80 min, 8, 12, and 48 hr, were fixed in glutaraldehyde and postfixed in OsO(4). The nucleus was only slightly changed by 48 hr soaking, but cytoplasmic organelles underwent developmental changes. There was proliferation of endoplasmic reticulum, the appearance of dictyosomes, and an inward migration of lipid bodies. Most of these changes were observed within 8 hr after soaking started. Plastids, mitochondria, protein bodies, and protein crystalline bodies were also identified and their developmental changes were followed.


Cross-striated arrays of filaments in endothelium.


A morphological analysis of binding of a hydrophobic probe to cells.


Selective presentation of DNA-regions and membranes in chloroplasts and mitochondria.


The three-dimensional reconstruction of the XY chromosomal pair in human spermatocytes. The spatial reconstruction of the XY pair of chromosomes from human spermatocytes has been made by the study of serial sections 1000 A in thickness. The sex pair during zygotene-pachytene forms a condensed mass of chromatin that has two filamentous, electron-opaque cores: the long and the short core. During early pachytene both cores have a common ending region, about 0.4-0.8 micro long. This common end is a synaptonemal complex, and each of the cores forms a lateral element of that complex. The cores become more convoluted during middle pachytene forming "ringlike bodies." Nucleoli from spermatocytes have three distinct regions: (a) granular; (b) dense fibrillar; and (c) clear intermediate. Occasional association of the XY pair and the heteropycnotic "basal knobs" results in apparent association of nucleoli and the sex pair in a minority of cells. The evidence presented is interpreted as a strong support of the hypothesis of homologous regions in the human XY pair.


Segregation and packaging of granule enzymes in eosinophilic leukocytes. During their differentiation in the bone marrow, eosinophilic leukocytes synthesize a number of enzymes and package them into secretory granules. The pathway by which three enzymes (peroxidase, acid phosphatase, and arylsulfatase) are segregated and packaged into specific granules of eosinophils was investigated by cytochemistry and electron microscopy. During the myelocyte stage, peroxidase is present within (a) all rough ER cisternae, including transitional elements and the perinuclear cisterna; (b) clusters of smooth vesicles at the periphery of the Golgi complex; (c) all Golgi cisternae; and (d) all immature and mature specific granules. At later stages, after granule formation has ceased, peroxidase is not seen in ER or Golgi elements and is demonstrable only in granules. The distribution of acid phosphatase and arylsulfatase was similar, except that the reaction was more variable and fully condensed (mature) granules were not reactive. These results are in accord with the general pathway for intracellular transport of secretory proteins demonstrated in the pancreas exocrine cell by Palade and coworkers. The findings also demonstrate (a) that in the eosinophil the stacked Golgi cisternae participate in the segregation of secretory proteins and (b) that the entire rough ER and all the Golgi cisternae are involved in the simultaneous segregation and packaging of several proteins.


Synthesis of glycoprotein, glycolipid, protein, and lipid in synchronized L5178Y cells. Synthesis of four macromolecular classes found in membranes-glycoprotein, glycolipid, protein, and lipid-was measured as a function of time of the cell cycle in synchronized L5178Y cells. Incorporation of leucine, choline, fucose, glucosamine, or thymidine into the cells, protein, nucleic acid, or lipid was measured by pulse-labeling for (1/2) hr at (1/2) hr intervals after release from the mitotic block. The amount of protein, lipid, glycoprotein, or glycolipid released or secreted into the medium by the L5178Y cells was also measured as a function of time of the cell cycle. Cellular protein was found to be synthesized throughout the cell cycle, with the highest synthesis occurring in the S period; synthesis was depressed in the M period. Cellular glycoprotein was synthesized at approximately the same times as protein, except that the rates of glycoprotein synthesis in the S period relative to other periods were much greater than for protein. Secreted protein was synthesized throughout the cell cycle without any general pattern, except that secretion was elevated in the late S and G(2) periods. Secreted glycoprotein was similar to secreted protein. Cellular lipid and cellular glycolipid were synthesized almost exclusively in the G(2) and M periods; there was no synthesis in the G(1) and S periods. Release or secretion of glycolipid and lipid also occurred in the G(2) and M periods.


Isolation, ultrastructure, and biochemal characterization of glycogen in insect flight muscle. Glycogen from flight muscle of the blowfly, Phormia regina, has been characterized ultrastructurally and biochemically. In situ, glycogen is in the form of rosettes, which vary in size with diameters of up to 0.1 micro. Sedimentation analysis of pure glycogen, isolated by mild buffer extraction, reveals a polydisperse molecular weight spectrum, with larger particles having molecular weights of 100 million. Treatment of native glycogen with alkali, under conditions usual for the extraction of the polysaccharide from tissues, results in a 5- to 10-fold reduction in molecular weight, as well as a chemical alteration of the molecule. Flight muscle phosphorylase has a lower affinity for native than for alkali-treated glycogen. The maximum velocity of the enzyme is also lower with native substrate. The apparent K(m) for inorganic phosphate is higher with native glycogen as cosubstrate. These kinetic differences with native and partially degraded glycogen demonstrate the importance of using the natural substrate in studies of biochemical control mechanisms.


Observations on a transient phase of focal swelling in degenerating unmyelinated nerve fibers. This study describes the nature and time-course of a swelling phase during the degeneration of unmyelinated nerve fibers, as observed in highly organized cultures of rodent sensory ganglia. Observations were made on nerve fascicles after they were cut and during nutritional deprivation. About 12 hr after nerve transection, large, clear vacuoles appear throughout fascicles distal to the cut. These vacuoles are most numerous at 24 hr and then gradually subside; after 48 hr, only small granules mark the severed fascicles. Electron microscopy shows that the vacuoles are, in fact, massive focal dilations of unmyelinated axons. Similar focal dilations in unmyelinated axons are observed if cultures are not refed for 5-7 days; under these conditions glucose concentrations fall below 20 mg/100 ml and degenerative changes begin to appear in neuronal somas. If the gas-tight assembly is opened and the culture refed, there is rapid disappearance of axonal dilations (usually within 1 hr) and recovery of many of the damaged neurons. Cooling (4 degrees C) prevents this reversal, suggesting that an active process is involved. It is postulated that the swellings result from the failure of active axolemmal ion-pumping mechanisms prior to loss of selective permeability in the axon membrane. The reasons for the focal nature of the swellings is unknown. A literature review indicates that a phase of focal swelling has frequently been observed during the degeneration of unmyelinated nerve fibers in vivo.


The nature and processing of ribosomal ribonucleic acid in a dinoflagellate. Certain features of the dinoflagellate nucleus suggest that it represents a primitive form of eukaryotic nucleus. For this reason, it was of interest to characterize dinoflagellate ribosomal RNA (rRNA) and its mode of synthesis to determine if it also deviated from typical eukaryotic patterns. Gyrodinium cohnii was chosen for this examination. Gyrodinium ribosomal RNA species are 16 and 25s as judged by their sedimentation velocities in isokinetic sucrose gradients. These values are typical of higher plants. In addition, the RNA cosedimented precisely with rRNA from the ciliate Tetrahymena. Nucleotide ratio analyses revealed a GMP + CMP content of 46% for both species of rRNA. The kinetics of incorporation of a radioactive precursor into ribosomal RNA have also been studied, and it seems likely that the maturation of rRNA starts with the synthesis of a 38s molecule. This serves as precursor to the 16s species, and, after a 27s intermediate, the 25s ribosomal component. The process is similar to that in other eukaryotes. The structure of the nucleolus has also been examined, and is seen to be typically eukaryotic.


Fine structural localization of peroxidase activity in the epithelium of large intestine of rat.


An ultrasensitive assay for soluble sulfhydryl and its application to the study of glutathione levels during the HeLa life cycle.


The influence of pH and osmolality on fixation of the fowlpox virus core.


The onset of electrical communication between cells in the developing starfish embryo.


Sedimentation properties of rat liver mitochondria. Effects of cortisone treatment. A prediction of the velocity of sedimentation of rat liver mitochondria in sucrose gradients is made on the basis of recent measurements of the size of isolated mitochondria suspended in sucrose medium and the model proposed by Bentzel and Solomon to describe the osmotic behavior of mitochondria. The experimentally observed velocity is extremely close to the predicted value and confirms by a different approach the estimate of mitochondrial volume made by Baudhuin and Berthet on the basis of electron microscopic measurements. Because cortisone treatment of rats is known to result in a marked increase in mitochondrial size as observed under the electron microscope, mitochondria were co-isolated from livers of control and cortisone-treated animals, and the sedimentation behavior of the mixtures was examined by sucrose density gradient centrifugation. Mitochondria from cortisone-treated animals were found to sediment 1.4 times as rapidly as those from control animals, indicating that their increased size cannot entirely be due to an increased imbibition of fluid from the surrounding sucrose medium, and that the change in size must at least in part be due to a change in content of nondiffusible mitochondrial components. Although the increase in sedimentation velocity of mitochondria from cortisone-treated animals is striking, it is less than that predicted solely on the basis of their size relative to that of control mitochondria. It is concluded that the increases in mitochondrial size and content of nondiffusible components produced by cortisone treatment are accompanied by alterations in mitochondrial composition as well.


Studies on the posterior silk gland of the silkworm Bombix mori. IV. Ultracentrifugal analyses of native silk proteins, especially fibroin extracted from the middle silk gland of the mature silkworm. Ultracentrifugal analyses of the native silk proteins extracted from the various parts of the middle silk gland of the mature silkworm have revealed that there exist four components with S degrees (20,w) values of 10S, 9-10S, 9S, and 4S in the extract. It is suggested that the fastest 10S component is the native fibroin synthesized in the posterior silk gland and transferred to the middle silk gland to be stored there, while the slower three components probably correspond to inner, middle, and outer sericins which were synthesized in the posterior, middle, and anterior portion of the middle silk gland, respectively. Native fibroin solution was prepared from the most posterior part of the middle silk gland. Ultracentrifugal analyses have shown that the solution contains considerable amounts of aggregates in addition to the main 10S component. Treatment with lithium bromide (LiBr), urea, or guanidine hydrochloride solution up to 6 M all have failed to dissociate the 10S component. From the sedimentation equilibrium analyses and partial specific volume of 0.71(6), the molecular weight of the 10S component of the native fibroin solution was found to be between 3.2 - 4.2 x 10(5), with a tendency to lie fairly close to 3.7 x 10(5).


The ultrastructure of the neuromuscular junctions of mammalian red, white, and intermediate skeletal muscle fibers. Distinct ultrastructural differences exist at the neuromuscular junctions of red, white, and intermediate fibers of a mammalian twitch skeletal muscle (albino rat diaphragm). The primary criteria for recognizing the three fiber types are differences in fiber diameter, mitochondrial content, and width of the Z line. In the red fiber the neuromuscular relationship presents the least sarcoplasmic and axoplasmic surface at each contact. Points of contact are relatively discrete and separate, and axonal terminals are small and elliptical. The junctional folds are relatively shallow, sparse, and irregular in arrangement. Axoplasmic vesicles are moderate in number, and sarcoplasmic vesicles are sparse. In the white fiber long, flat axonal terminals present considerable axoplasmic surface. Vast sarcoplasmic surface area is created by long, branching, closely spaced junctional folds that may merge with folds at adjacent contacts to occupy a more continuous and widespread area. Axoplasmic and sarcoplasmic vesicles are numerous. Both axoplasmic and sarcoplasmic mitochondria of the white fiber usually contain intramitochondrial granules. The intermediate fiber has large axonal terminals that are associated with the most widely spaced and deepest junctional folds. In all three fiber types, the junctional sarcoplasm is rich in free ribosomes, cisternae of granular endoplasmic reticulum, and randomly distributed microtubules.


Immunoglobulin synthesis and secretion. I. Biosynthetic studies of the addition of the carbohydrate moieties. This study was designed to determine the time in the intracellular life of immunoglobulin when the carbohydrate moieties are added. Plasma cells from a mouse myeloma tumor were exposed to glucosamine-(3)H (a "bridge" sugar), galactose-(3)H, or leucine-(3)H. With each of the above isotopes, the percentage of total radioactive immunoglobulin that has been secreted after different periods of labeling and the extent to which puromycin prevented incorporation into immunoglobulin were determined. The results indicate that both galactose and glucosamine (in its N-acetyl form) become covalently incorporated into immunoglobulin G late in its intracellular life and suggest that glucosamine is also added onto nascent polypeptide chains (i.e., on polyribosomes).


Proliferative behavior of differentiating cells in the developing rat parotid gland. Parotid glands of litters of rats at age intervals from 20 days in utero to 100 days were assayed for DNA content and examined by light- and electron-microscopy. The age differences in total DNA and DNA concentration indicated that there was a rapid rate of proliferation of parenchymal cells until 25 postnatal days, after which the rate declined rapidly, and that there was a rapid increase in cell size between 18 and 25 days. These findings were substantiated by histologic observations, such as the presence of numerous mitotic figures until 25 days of age, and the rapid maturation of the acinar cells between 18 and 25 days. These data suggest that the acinar cells of the rat parotid gland comprise an expanding cell population. Light- and electron-microscopic observations consistently indicated that cells with mitotic figures were about as well differentiated as other parenchymal cells at all stages of gland development, including mature acinar cells observed at ages 23 and 25 days. These observations support the view that the division of cells in advanced stages of differentiation may be important in the growth of certain organs and tissues.


The appearance of acetylcholinesterase in the dorsal root neuroblast of the rabbit embryo. A study by electron microscope cytochemistry and microgasometric analysis with the magnetic diver. In the nine day old embryo, acetylcholinesterase (AChE) is found in the reticulum, i.e. the nuclear envelope, endoplasmic reticulum, and Golgi complex, of a few cells in the neural crest. When the neurite first enters the neural tube, reticulum-bound enzyme is present also in the varicosity of the growth cone of the bipolar neuroblast. At later stages, AChE in the neuroblast has a dual distribution; in addition to the reticulum, activity also appears at the axolemmal surface. The axolemmal activity is found initially on the distal portions of axons in the posterior fasciculus and then progressively appears along the nerve roots in a distal to proximal direction. Very little reticulum-bound enzyme is present within the axon proper. After the 13th day the levels of AChE activity in the posterior fasciculus greatly exceed those in the dorsal root or in the ganglion. Enzymatic activity in the dorsal root equals or exceeds that in the posterior fasciculus by day 16, and both areas are considerably more active than the ganglion.


Human monocytes and macrophages. Interaction with antigen and lymphocytes. PPD-sensitized monocytes and macrophages from tuberculin-positive subjects are both capable of inducing blastogenic transformation of autologous lymphocytes. Incorporation of thymidine-(3)H and morphological transformation were always greater in lymphocyte cultures containing macrophages than in those containing monocytes. More lymphocytes entered the first detectable S phase in cultures containing macrophages. Lymphocyte DNA synthesis occurred as early as 40 hr of culture and always in cells in contact with mononuclear phagocytes. By 120-144 hr, many transformed lymphocytes were free in suspension; at the same time, the "immunological cluster" had increased greatly in size and contained transformed and untransformed lymphocytes. The greater effectiveness of macrophages at induction of lymphocyte transformation may be related to the efficiency of this cell type at trapping antigen and its effectiveness at making contact with and binding lymphocytes.


Chromatography of native and gamma-irradiated lysozymes on dense gels.


Adsorption of lysozyme to polyacrylamide gel (bio-gel P-2).


Analysis of antibiotics by gas chromatography. II. Chloramphenicol.


The chromatographic separation of magnesium protoporphyrin IX dimethyl esters from zinc protoporphyrin IX dimethyl esters.


Use of anionic liquid ion exchangers in the chromatography of steroidal glucosiduronic acids.


Identification of alkaloid-containing drugs by thin-layer chromatography after micro steam distillation.


Role of serum protective factor and neutralizing antibody in pathogenesis of experimental infection with Langat virus in mice.


Trends in meningococcal disease.

Trends in meningococcal disease.


"The use of Locorten (flumethasone pivalate) cream in the treatment of common dermatoses".


Synthesis of analogs of the C-terminal octapeptide of cholecystokinin-pancreozymin. Structure-activity relationship.


Hypocholesteremic agents. I. Substituted stilbazoles and dihydrostilbazoles.


Thyroxine analogs. 18. 3,5-dialkyl-3'-halo-DL-thyronines and their 3'-methyl and 4'-amino analogs.


8-hydroxyinoline derivatives. Synthesis and biological evaluation of arylglyoxal N-7-amino-5-substituted 8-hydroxyquinoline hemiacetals and 5-phenylglyoxylidenamin-8-hydroxyquinolines.


Potential antimalarials. IV. Quinoline-alpha,alpha-dialkylmethanols.


Synthesis and pharmacological evaluation of alpha-naphthylakylamines.


2-Fluoropurine ribonucleosides.

2-Fluoropurine ribonucleosides.


Fragmentation pattern of 1,4-benzodiazepin-2-ones under electron impact.


Agents acting on the central nervous system. 13. 2,3,4,4a,5,6-hexahydro-1(H)-pyrazino[1,2-a]quinolines. A new class of hypotensive agents.


Benzo[g]quinolines. II. Novel synthesis and pharmacological evaluation of cis-1-alkyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolines.


Chlorosulfonation of 17-beta-acetoxy-3-methoxyestra-1,3,5(10)-triene.


Thia steroids. II. 2-thia-A-nor-5-alpha-pregnan-20-one.


Pyrolysis of 16-methylene 17-oxygenated-20-keto steroids. IV. Synthesis of 3-hydroxy-1,3,5(10)-estratrieno[17,16-c]-2'-methylfuran.


Synthesis of potential anticancer agents. 5,12-naphthacenequinones.


Glycylureas and quaternary salts.

Glycylureas and quaternary salts.


Antitumor activity of some azine and hydrazone derivatives of 1,4-dimethoxy-2-butanone.


Potential antineoplastics. 3. A series of 1-thiocarbamoyl-3-methyl-4-arylzo-5-methyl(or phenyl)pyrazoles.


Synthesis of mono-, di-, and trimethoxy derivatives of N,N-bis(2-chloroethyl)aniline and related compounds as antitumor agents.


Benzylidene hydrazides as potential anticancer agents.


Some substituted [p-(ethoxyphenyl)anilino]acetamides.


Comparison of infectivity of strains of Trypanosoma cruzi (Chagas, 1909).


Embryonic response to Eimeria tenella infection.


Cytochemistry of the pellicle of bloodstream forms of Trypanosoma (Trypanozoon) brucei.


Cytological studies on the absorptive surfaces of cestodes. IV. Localization and cytochemical properties of membrane-fixed cation binding sites.


Haemaphysalis (Kaiseriana) ramachandrai sp. n. (Ixodoidea, Ixodidae), a parasite of man and domestic and wild mammals in Northern India and Nepal.


Further studies on the development of Angiostrongylus cantonensis in the Formosan mongoose.


Efficacy of Cambendazole against Trichinella spiralis in mice.


Aminosteroids.

Aminosteroids.


Sterically hindered esters of vitamin A. II. Vitamin A alpha, alpha-dimethylpalmitate.


Action of psychotogenic drugs on single midbrain raphe neurons.


An analysis of ephedrine mydriasis in relationship to iris pigmentation in the guinea-pig eye in vitro.


Roth RH: Influence of sympathetic nerve stimulation on conversion of H3-tyrosine to H3-catecholamine and on H3-norepinephrine disposition in rabbit pulmonary artery.


Ryanodine-induced contractile failure of skeletal muscle.


The neuromuscular pharmacology of germine-3-acetate and germine-3,16-diacetate.


Relationship among contraction, drug binding and positive inotropic action of digoxin.


The acute effects of mefruside in man: a new diuretic compound.


The effect of glucagon on calcium exchangeability, coronary blood flow, myocardial function and high energy phosphate stores.


Differential effect of furosemide on renal and limb blood flows in the conscious dog.


A reevaluation of the Markham rotation technique using model systems.


Terotogenic effects in the chick embryo caused by esters of phthalic acid.


Daily rhythm in the accumulation of brain catechol-amines synthesized fom circulating H3-tyrosine.


Immunophagocytosis of human amyloid fibrils by leukocytes.


Electron microscopy of DNA in mitochondria of pea seedlings.


Quantitation of the ultrastructural components of nucleoli of rat trigeminal ganglia.


Ultrastructure of guinea pig mast cells.


A new model for mitochondrial membranes based on structural and on biochemical information.


Ultrastructure of the postmeiotic nuclear envelope in microspores of Podocarpus macrophyllus.


Neuromuscular and axoaxonal synapses of the crayish opener muscle.


The measurement of plasma delta-4-androstenedione by competitive protein binding.


Inhibition of cholesterol side chain cleavage by cyanoketone.


A-nor oxa steroids. II. A-nor oxa pregnanes.


Further studies on corticosteroidogenesis. VII. Factors influencing the utilization of pyruvate for steroid 11-beta-hydroxylation by rat adrenal mitochondria.


Prolonged endotracheal intubation.

Prolonged endotracheal intubation.


Medicopter: an airborne intensive care unit.


Presidential address: crisis and apathy.


Screen filtration pressure in combat casualties.


Blood sugar and insulin response of humans in shock.


Prophylactic diuresis with ethacrynic acid for prevention of postoperative renal failure.


Topical and systemic antibacterial agents in the treatment of burns.


Serum gastrin levels in malignant Zollinger-Ellison Syndrome after total gastrectomy and hypophysectomy.


Chemical evidence for a functional carboxyl group in carboxypeptidase A.


Interaction of the erythrocyte--membrane protein, spectrin, with model membrane systems.


A new intermediate in plant cell wall synthesis.


The specificity of the Vi-phage II bacteriolytic enzyme.


Discrimination by rat liver aminoacyltransferase I against Met-tRNA-F.


Purification of photosystem I reaction centers from spinach stroma lamellae.


An effect of pactamycin on the initiation of protein synthesis in reticulocytes.


In vitro studies on the enzymic biosynthesis of the collagen crosslinks.


Regulation of glutamine synthetase in the embryonic neural retina in organ culture.


A specific apoprotein activator for lipoprotein lipase.


Ribonucleotide reductase from Saccharomyces cerevisiae.


Selective inhibition by cycloheximide of nuclear DNA synthesis in synchronous cultures of Chlorella.


An appraisal of methionine-tryptophan interrelationships in mental illness: methylation reactions involved.


An unusual exonuclease activity associated with Micrococcus luteus DNA polymerase.


CNS effects of the aldehyde products of brain monoamines.


Digital computer sleep prints in lobotomized and nonlobotomized schizophrenics.


The biological investigation of schizophrenia.


The life course of schizophrenic children.


Chronic amphetamine effect on the olfactory forebrain.


A matter of priorities.

A matter of priorities.


Training for research.

Training for research.


Perspectives for biological psychiatry.

Perspectives for biological psychiatry.


Chromosomal mosaicisms and occasional acentric chromosomal fragments in schizophrenic patients.


The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.


Dielectric constant of gastric juice as transfer agency.


Electric capacity in an artificial gastric juice.


LATS and recurrent thyrotoxicosis after subtotal thyroidectomy.


Protein deprivation and the measurement of albumin synthesis.


The influence of exogenous and endogenous steroids on hepatic microsomal enzyme induction.


Drug-metabolizing capacity and drug dependence.


Induction of drug metabolizing enzymes in man.


Leucine naphthylamidase activity in rat pancreas.


The effect of prolonged hyperoxia on cardiovascular dynamics.


Measurement of distribution of cardiac output in dogs using macroaggregated iodinated 131-I human serum albumin.


The 86 Rubidium assay method for determining plasma and tissue digitalis levels.


Velocity profiles in the ascending aorta.


Mechanism of closure of the mitral valve.


Raised L-glutamate and 2-oxoglutarate concentrations associated with chronic hypercapnia and hypoxaemia.


Peptide chain synthesis in unstable haemoglobin diseases.


Effect of brief hypercalcaemia on free water reabsorption during solute diuresis: evidence for impairment of sodium transport in Henle's loop.


The generation of kinins in the blood of dogs during hypotension due to haemorrhage.


Some effects of metabolic acidosis on carbohydrate metabolism in the rat.


Renal function studies in renal carcinoma.


Glomerular permeability during proteinuria induced by plasma infusion.


Chest movements in patients with traumatic injuries of the cervical cord.


The effect of dichlorphenamide on blood and cerebrospinal fluid acid-base state in chronic ventilatory failure.


Lysozyme excretion as a measure of renal tubular dysfunction in children.


The natriuresis of fasting: relationship to changes in plasma renin and plasma aldosterone concentrations.


Enzyme induction: introduction.

Enzyme induction: introduction.


Enzyme induction of drug oxidizing enzymes.


Nutrition and enzyme induction.

Nutrition and enzyme induction.


Steroids and enzyme induction.

Steroids and enzyme induction.


Interactions of ethanol, drug and lipid metabolism; adaptive changes after ethanol consumption.


Enzyme induction and bilirubin metabolism.


Remissions in Paget's disease produced by human synthetic calcitonin (calcitonin M).


Auditory laterality and tested handedness.


Role of the right parietal lobe in the mediation of cross-modal associations and reversible operations in space.


On the contribution of studies in aphasia to psycholinguistics.


Syntactic comprehension in aphasia.

Syntactic comprehension in aphasia.


Hemispheric contribution to exploration of space through the visual and tactile modality.


Isolated writing disorders in a patient with stenosis of the left internal carotid artery.


Ethylene oxide sterilization.

Ethylene oxide sterilization.


The admitting nurse coordinator.

The admitting nurse coordinator.


Tray assembly procedures.

Tray assembly procedures.


A time for a team.

A time for a team.


Involvement of consumers.

Involvement of consumers.


The ineffective trustee.

The ineffective trustee.


Professional liability.

Professional liability.


Arbitration.

Arbitration.


Volunteer engineering program.

Volunteer engineering program.


Nosocomial infections.

Nosocomial infections.


Renovation improves service.

Renovation improves service.


Hospital fire protection.

Hospital fire protection.


Reactions of labile metal ions with oligopeptides. V. Copper (II) with glycylglycine and glycylsarcosine.


A search for an intermediate in carboxypeptidase A catalyzed ester hydrolyses.


Studies on the desulfonylation of 2-hydroxy-5-nitro-alpha-toluenesulfonyl-alpha-chymotrypsin.


Hashish. A stereospecific synthesis of (-) delta 1 and (-) delta 1(6) tetrahydrocannabinols.


Structure of chelocardin, a novel tetracycline antibiotic.


Identification of the rate-limiting step in the chymotrypsin-catalyzed hydrolysis of N-acetyl-L-tryptophanamide.


Studies on the synthesis of monomeric and dimeric vinca alkaloids. The total synthesis of isovelbanamine, velbanamine, cleavamine, 18 beta-carbomethoxycleavamine, and catharanthine.


Dietetics in regional medical programs.

Dietetics in regional medical programs.


Dietetic manpower trends in education and training.


Mineral balance in treated phenylketonuric children.


Plasma amino acids in subjects on three diets.


Major mineral elements in type A school lunches.


Thalamotelencephalic projections in the turtle (Pseudemys scripta).


Stereotaxic atlas of the hypothalamus of the Mongolian gerbil (Meriones unguiculatus).


Relationships between glial and neuronal elements in the development of long term cultures of the spinal cord of the fetal mouse.


Telencephalic projections of the nucleus rotundus in the pigeon (Columba livia).


Visual intensity and pattern discrimination deficits after lesions of ectostriatum in pigeons.


Topical projection of the olivocerebellar system in the cat: an electrophysiological study.


The effects of wulst ablations on color, brightness and pattern discrimination in pigeons (Columba livia).


Physiological variations in prolactin content of the mouse pituitary gland examined by disc electrophoresis and bioassay.


Influence of methyltestosterone and cyproterone acetate on Wolffian duct differentiation in female rat foetuses.


The role of the oestrogen secreted before oestrus in the preparation of the uterus for implantation in the mouse.


Homotransplantation of ovaries with vascular anastomoses in rabbits: response of transplants to human chorionic gonadotrophin.


Pigeon crop sac-stimulating activity in the pituitary of the flounder (Pleuronectes flesus).


The effect of neurohypophysial hormones on the amphibian oviduct in vitro, with some remarks on the histology of this organ.


An evaluation of the method of Cox for the rapid analysis of pregnanediol in urine by gas-liquid chromatography.


The relation of cardiac output to plasma cortisol clearance rates in shorn sheep during exposure to a cold, wet environment.


Cortisol utilization by salivary gland, kidney and adrenal cortex.


Lactate, pyruvate and thyroid function.

Lactate, pyruvate and thyroid function.


Retention of oestradiol-17beta applied locally in the uteri of ovariectomized mice treated with progesterone.


Legalize marihuana?

Legalize marihuana?


Carcinoma of the breast, St Vincent's Hospital Breast Tumour Clinic, 1954-1965. The method of analysis of cases.


Carcinoma of the breast: St. Vincent's Hospital series, 1954-1965. The effects of childbearing on carcinoma of the breast.


Cancer, food additives and medical information services.


A report from the Australian drug evaluation committee: oral contraceptives and thromboembolic disease. The Australian Drug Evaluation Committee has evaluated data from the United Kingdom and from Australia as well as overseas concerning the relationship between thromboembolic disease and the estrogen content of oral contraceptives (OC).  The Committee has concluded that withdrawal from the market of higher estrogen dosage OCs is unnecessary.  However, based on available evidence, the Committee recommends the dispensing of OCs containing the lowest dose of estrogen which is effective and suitable to  the patient.  Higher dosage OCs should be used only when specifically indicated.


Continuous muscle fibre activity (Isaacs).


Primary melanoma of the leptomeninges.

Primary melanoma of the leptomeninges.


Giant hairy naevi and leptomeningeal primary malignant melanoma.


Raised intracranial pressure as a mode of presentation in tuberculous meningitis.


Lumbar disc prolapse. A study of 251 operated cases.


Spinal epidural meningiomas.

Spinal epidural meningiomas.


Aphasia.

Aphasia.


The brain and meninges in tuberculous meningitis-gross pathology in 100 cases and pathogenesis.


Where prevention starts.

Where prevention starts.


Hearts and drivers.

Hearts and drivers.


Quality control.

Quality control.


Levodopa: problems, promise, patience and persistence.


Pain-basic principles of management.

Pain-basic principles of management.


Cancer pain.

Cancer pain.


Nerve blocks.

Nerve blocks.


The pain-prone patient.

The pain-prone patient.


Operant conditioning as a treatment method in management of selected chronic pain problems.


Artificial ventilation. 1. Normal respiratory mechanism and function.


Outpatient surgery.

Outpatient surgery.


The forgotten men.

The forgotten men.


Nurse education in North America.

Nurse education in North America.


I am on cortisone.

I am on cortisone.


Objectives in psychiatric nursing.

Objectives in psychiatric nursing.


Perforated peptic ulcer.

Perforated peptic ulcer.


Haemodialysis and hepatitis; the hazards.


Every child a wanted child.

Every child a wanted child.


Hams in bed.

Hams in bed.


How not to obtain student nurses. 2.

How not to obtain student nurses. 2.


Implications of the 1969 General Nursing Council Syllabus of the Nursing Service.


Brief psychotherapy and the confrontation approach.


Organic disease presenting as hyperventilation syndrome.


Use of pelvic pneumography in planning radiotherapy of endometrial carcinoma.


The response to Stewart-Treves syndrome to radiotherapy.


A method for varying the effective angle of wedge filters.


Treatment of labile hypertension.

Treatment of labile hypertension.


Psychotropic agents in the coronary patient: what and when.


The interrelationship between anxiety and arrhythmias.


A controlled study of preoperative irradiation in cancer of the sigmoid colon and rectum. Preliminary report.


Split-dose radiotherapy for bladder carcinoma. 94 cases treated from 1960 through 1966.


Ten-year experience with linear accelerator irradiation of cancer of the nasopharynx.


Psychogenic impotence with a hypnotherapy. Case Illustration.


Social work in group medical practice.

Social work in group medical practice.


Psychiatric aspects of the pre-and post-surgical patient.


Effects of x radiation and actinomycin D on intestinal epithelium of dogs.


Performance of a new 4 MeV standing wave linear accelerator.


A possible link between diurnal variations in radiation sensitivity and cell division in bone marrow of male mice.


RPC of the month from the AFIP.

RPC of the month from the AFIP.


A simple radiographic method and epidemiologic study of atherosclerosis.


Applications of systems analysis in a diagnostic radiology department.


Ketipramine in the therapy of depression in outpatients.


Tantalum esophagography. A preliminary clinical evaluation.


Contamination of barium sulfate suspension.


Indoklon: convulsive therapy experimental--clinical studies.


Usefulness of calcium ipodate in the faintly opacified gallbladder.


Technique of colostomy examination.

Technique of colostomy examination.


Suprapatellar effusions. A new diagnostic sign.


Anisotropic subtraction and edge-enhancement of roentgenographic images.


Aortography in experimental renal failure. Evaluation of contrast media toxicity.


Ascending phlebography and iliac vein opacification.


Angiographic findings in pheochromocytoma of the organs of Zuckerkandl.


Metastatic calcification in cystic fibrosis. A report of two cases.


The urinary mucosal barrier in retrograde pyelography. The role of the ureteric mucosa.


Value of cerebral angiography in the embolization treatment of cerebral arteriovenous malformations.


A new roentgenographic method of measuring the retrogastric and retroduodenal spaces: statistical evaluation of reliability and diagnostic utility.


The use of a semisolid contrast medium in a defecography.


Reversible right colonic strictures in chronic ulcerative colitis.


Carcinoid tumor presenting as annular lesion in the ascending colon.


Inversion of the liver and suprahepatic gallbladder associated with eventration of the diaphragm.


Intubation with telescoping of small bowel.


Parotid sialography in Sjögren's syndrome.


Superior laryngeal nerve block.

Superior laryngeal nerve block.


Sensitivity of brain scanning in the detection of arteriovenous malformations.


Simple radiologic demonstration of cortical bone loss in thyrotoxicosis.


The 'mutilated ovary' syndrome.

The 'mutilated ovary' syndrome.


Familial occurrence of an abnormal Y chromosome.


Thyrotoxicosis in the Bantu, with special reference to myopathy.


Carcinoma of the duodenum: a case report.


Man's hidden madness or defence against insanity.


Marihuana, the plant.

Marihuana, the plant.


The problem of pot. Pharmacology and chemistry.


The medical effects of marihuana.

The medical effects of marihuana.


Marihuana, a psychiatric point of view.

Marihuana, a psychiatric point of view.


Marihuana and society.

Marihuana and society.


Closing remarks.

Closing remarks.


Marihuana laws.

Marihuana laws.


Mechanical properties of tracheal smooth muscle and effects of O2, CO2, and pH.


Stimulation by glucose of fatty acid synthesis in human platelets.


Choleretic effects of cholecystokinin, gastrin II, and caerulein in the dog.


Sodium, potassium, and water content of isolated bullfrog small intestinal epithelia.


Glycine transport in rabbit ileum.

Glycine transport in rabbit ileum.


Radiosensitivity of mice exposed to various temperatures and low-dose rate radiation.


Renin production and release by rat kidney slices.


Amiloride inhibition of ion transport in perfused excretory duct of rat submaxillary gland.


Amino acid catabolism in environmental extremes: effect of temperature and calories.


Action of cholinergic drugs on Necturus gastric mucosa.


Filtration fraction and extraction of PAH during neonatal period in the rat.


Differences in responses of saphenous and mesenteric veins to reflex stimuli.


Function of ascending loop of Henle in the potassium-deficient dog.


Effect of phloridzin on uric acid excretion in man.


Regulation of glycogenolysis in hearts: effects of pressure development, glucose, and FFA.


Renal response to solute loading in infant rats: relation to anatomical development.


Scaling of energetic cost of running to body size in mammals.


Decrease in K+ conductance and depolarization of frog cardiac muscle produced by Ba++.


Strategies of temperature regulation: effect on evaporation in East African ungulates.


Accelerated synthesis of urea in Xenopus laevis during osmotic stress.


Dehydration and heat: effects on temperature regulation of East African ungulates.


Thromboplastin and plasminogen activator in tissues of the rabbit.


Electrical properties of axons of Callinectes sapidus.


Adrenal cortical and medullary hormones in recovery of tissues from local injury.


Vitamin K and warfarin distribution and metabolism in the warfarin-resistant rat.


Fasting and alloxan diabetes effects of intestinal transport of monosaccharides.


Genetic variation in patterns of nephron function during natriuresis in mice.


Chemical evidence for early but unsustained growth in the obstructed mouse kidney.


Effect of MgCl2 infusion on urinary Ca and Na during reduction in their filtered loads.


Phlorizin and renal phosphate secretion in the spiny dogfish Squalus acanthias.


Glucose metabolism and chronic acceleration.


Efferent splanchnic activity and systemic arterial pressure.


Natriuretic effect of increased proximal delivery in dogs with salt retention.


In vivo demonstration of differences in substrate oxidation in normal and nephrotic rats.


Blood gases in hamsters during hypothermia by exposure to He-O2 mixture and cold.


Lysosomes and hepatic regression during fasting.


A direct action of insulin on the hypothalamic satiety center.


Vitamin D, tissue calcium, and calcium transport in the in vivo rat small intestine.


Velocity of propagation in vertebrate cardiac muscles as functions of tonicity and [K+].


Pancreatic bicarbonate response to various acids in duodenum of the dog.


Pancreatic response to acidification of various lengths of proximal intestine in the dog.


Proximal tubular energy metabolism, sodium transport, and permeability in the rat.


Pulmonary arterial and venous response to cooling: role of alpha-adrenergic receptors.


Dissociation between autoregulation of renal blood flow and glomerular filtration rate.


Mental health and social change: an ecological perspective.


Patterns of drug use: a study of 5,482 subjects.


Campus disorders: a problem of adult leadership.


Schizophrenia in twins and the diffuse ego boundary hypothesis.


Nurse and patient responses to a study of milieu therapy.


Group therapy with multiple therapists in a large group.


Home from the war: a study of psychiatric problems in Viet Nam returnees.


The civilian psychiatrist and the draft.


Military psychiatry and the Viet Nam experience.


Psychiatric aeromedical evacuation patients during the Tet and Tet II offensives, 1968.


Psychiatric criteria for compassionate reassignment in the army.


A new emphasis on administrative psychiatry.


Psychiatric television consultation for the mentally retarded.


Patients who flirt with treatment: the silent population.


Cardiac arrhythmias during electroshock therapy: significance, prevention, and treatment.


Electrosleep--a clinical trial.

Electrosleep--a clinical trial.


The ethics of abortion.

The ethics of abortion.


Psychosomatic ocular irritation.

Psychosomatic ocular irritation.


The need to limit radio and television dosage.


Calvarial thickening after Dilantin medication.


The contracting skull. Inward growth of the inner table as a physiologic response to diminution of intracranial content in children.


Laminography of the mastoid in the basal projection.


Orbital sclerosis in histiocytosis X.

Orbital sclerosis in histiocytosis X.


Ocular hypertelorism (Greig's syndrome) associated with Sprengel's deformity.


Arteriovenous malformations involving the Galenic system.


Intracranial solitary chondroma of dural origin.


A new simple measurement of pineal calcification in the lateral craniogram.


Should black children learn white dialect?


Third party payment abuses.

Third party payment abuses.


Immunological studies on peptides from the haptenic C-terminal octapeptide of Clostridium pasteurianum ferredoxin.


Structural and functional factors in the lyotropic activity of amides and alkyl-substituted amides on acid-soluble collagen.


Conformational changes associated with f-1 histone-deoxyribonucleic acid complexes. Circular dichroism studies.


Characterization of a yeast endonuclease.


Effects of divalent cations on activity and specificity of streptococcal nucleases B and D.


Reaction of sodium bisulfite with uracil, cytosine, and their derivatives.


Aminoethylation of thiopyrimidine nucleosides.


Interactions between cytidine and its cation in polycytidylic acid, cytidylyl-3'-cytidine, and cytidine aggregates.


Metabolism of ubiquinone-7.

Metabolism of ubiquinone-7.


Synthesis of ubiquinone-7 metabolites.

Synthesis of ubiquinone-7 metabolites.


An examination of the topography of the saccharide binding sites of concanavalin A and of the forces involved in complexation.


Bacterial bioluminescence. Comparisons of bioluminescence emission spectra, the fluorescence of luciferase reaction mixtures, and the fluorescence of flavin cations.


Isolation and characterization of the major protein component of sarcotubular membranes.


Association constant of the sex-specific agglutinin in the yeast, Hansenula wingei.


Choline acetyltransferase. Enzyme mechanism and mode of inhibition by a styrylpyridine analogue.


Purification and properties of hepatic glycogen synthetase of Rana catesbeiana.


Structural and steric specificity of alpha-chloroketones as inhibitors of alpha-chymotrypsin.


Alkylation of adenosine deaminase by benzylbromoacetate and 9-(p-bromoacetamidobenzyl)adenine.


Ligand-induced association-dissociation as a means for enzyme purification.


Spectrophotometric investigations of the interaction of native and chemically modified ATP: guanidinophosphotransferases with their substrates.


Social facilitation of feeding in newly hatched chickens as a function of imprinting.


Purification and properties of N-acetylneuraminate lyase from beef kidney cortex.


The role of motivation and orientation in sensory preconditioning.


Cue screening, cognitive elaboration, and heart-rate change.


Pupillary dilation and mediation processes during paired-associate learning.


Context effects in the generalization of a successive discrimination in human subjects.


Changes in self-stimulation preference as a function of incentive of alternative rewards.


The influence of ATP Riboflavin, Succinate, and Glutamate in vitro on the haemolytic action of Chlorpromazine.


Immuno-electrophoretic studies on the A antigen in human saliva.


Studies on lipase. Isolation and purification of a high molecular weight pancreatic lipase.


Isolation, characterization and C-terminal sequence of ovine growth hormone.


The mechanism of ion translocation in mitochondria. 2. Active transport and proton pump.


The mechanism of ion translocation in mitochondria. 1. Coupling of K+ and H+ fluxes.


An automated adaptation of the method of lowry and lopez for estimating inorganic phosphate.


The mechanism of ion translocation in mitochondria. 3. Coupling of K+ efflux with ATP synthesis.


Photodynamic action of porphyrins on amino acids and proteins. Spectral studies on mono and di-sulphoxide derivatives of lysozyme.


The mechanism of ion translocation in mitochondria. 4. Coupling of K+ efflux with Ca2+ uptake.


Studies on the metabolism of C19 steroids in rat liver. 6-Alpha hydroxylation of 3-oxo-delta 4-steroids in rat liver microsomes.


Chromatography of RNA-DNA complexes on hydroxyapatite. A method for the separation of the complementary strands in T2 DNA.


Energy dependent bivalent cation translocation in rat liver mitochondria.


Biosynthesis of cytochrome c. The sites of synthesis of apoprotein and holoenzyme.


The origin of mitochondrial phosphatidylcholine within the liver cell.


Electro-physiological analysis of oculo-motor mechanisms. (Vestibular, optic and central nystagmus).


Optokinetic nystagmus and attention.

Optokinetic nystagmus and attention.


The role of the optic pathways in the regulation of various forms of nystagmus.


Electromyographic contributions to human visual perception mechanisms.


Editorial.

Editorial.


A new peptide antibiotic complex S-520. II. Further characterization and degradative studies.


A new peptide antibiotic complex S-520. I. Isolation and characterization.


Isolation, characterization, and structure of rabelomycin, a new antibiotic.


Geldanamycin, a new antibiotic.

Geldanamycin, a new antibiotic.


Neomycins D, E and F: identity with paromamine, paromomycin I and paromomycin II.


Macrolide resistance in Staphylococcus aureus. Decrease of spiramycin-binding to 50S ribosomal subunit in macrolide resistant strains of staphylococci.


The presence of a common type of subunit in bovine thyroid-stimulating and luteinizing hormones.


Concerning the mechanism of ester hydrolysis by proteases.


The reaction of oxygen with hemoglobin and the kinetic basis of the effect of salt on binding of oxygen.


Phosphoribosyltransferase activity during early mammalian development.


Incorporation of lysozyme into liposomes. A model for structure-linked latency.


An infrared study of the hydrogen-deuterium exchange of alpha-chymotrypsin and its diisopropylphosphoryl derivative.


Studies on adenosine triphosphate transphosphorylases. IX. Kinetic properties of the crystalline adenosine triphosphate-creatine transphosphorylase from calf brain.


Identification and location of episilon-N-trimethyllysine in yeast cytochromes c.


Methionine toxicity and ornithine delta-aminotransferase in Chang's liver cells.


The effect of aliphatic alcohols on the helix-coil transition of poly-L-ornithine and poly-L-glutamic acid.


Incorporation of 3,4-dehydroproline into protocollagen and collagen. Limited hydroxylation of proline and lysine in the same polypeptide.


Crystalline L-aspartate beta-decarboxylase of Pseudomonas dacunhae.  II. Subunit and amino acid composition.


Dye-sensitized photooxidation as a tool for determining the degree of exposure of amino acid residues in proteins. The methionyl residues in ribonuclease A.


Reversibility of denaturation of the zymogen and the proteolyzed zymogen of streptococcal proteinase.


Dimethyl(2-hydroxy-5-nitrobenzyl)sulfonium salts. Water-soluble environmentally sensitive protein reagents.


Specific glucocorticoid receptors in thymus cells. Localization in the nucleus and extraction of the cortisol-receptor complex.


Changes in the nonnutritive sucking response to stimulation during infancy.


Studies in pattern detection in normal and autistic children. II. Reproduction and production of color sequences.


Recency and summation effects of nonreward in children.


Oddity preference by mental retardates.

Oddity preference by mental retardates.


The application of Premack's generalization on reinforcement to the management of classroom behavior.


An infant stabilimeter.

An infant stabilimeter.


Newborn attention: differential response decrement to visual stimuli.


Division delays and abnormal oral development produced by colchicine in Tetrahymena.


The effects of pressure on cell division and oral morphogenesis in Tetrahymena.


Age and capacity devaluation.

Age and capacity devaluation.


The internalization of social roles in institutionalized chronic mental patients.


Needle sharing in the Haight: some social and psychological functions.


Sex role differentiation in the professions: the case of Israeli dentists.


An electron microscopic and functional study of very low density lipoproteins in intestinal lymph. Previous studies with fasting rats showed that the intestine produces endogenous very low density lipoproteins (VLDL) which resemble those in the plasma. Intestinal VLDL also were found to be important in lipid transport during absorption of saturated but not of unsaturated fat. These findings depended upon separations of a chylomicron-rich fraction (S(f) > 400) from VLDL (S(f) 20-400) by preparative ultracentrifugation methods based on particle flotation rates. The present studies correlate this method with electron microscopic measurement of lipoprotein particle size. Almost all intestinal lymph lipoprotein particles from fasting rats were less than 750 A in diameter, and could not be distinguished morphologically from plasma VLDL. Cholestyramine administration or bile diversion led to decreased lymph lipid output, correlating with marked reduction in VLDL. This supports the concept that lymph VLDL contain endogenous lipid which is reabsorbed from the intestinal lumen. During exogenous fatty acid absorption, lymph lipoprotein particle sizes were significantly smaller after administration of palmitate than after administration of linoleate, a finding consistent with ultracentrifugal evidence of the importance of VLDL in lipid transport during palmitate absorption. These studies fully confirm and extend earlier observations. Together, they show that the intestine is a source of endogenous VLDL in the fasting animal. In addition, significant quantities of exogenous lipid are transported in VLDL during palmitate absorption, whereas with linoleate absorption nearly all lipid is in chylomicrons. These findings indicate that the small intestine plays a role in lipoprotein metabolism which extends beyond the absorption of dietary fat.


Computer treatment of gas-liquid chromatographic data, with special reference to fatty acid methyl esters. A computer program is described which analyzes output punched directly onto paper tape from a gas-liquid chromatograph. Although this program was written specifically for samples of fatty acid methyl esters derived from adipose tissue triglycerides which are eluted within 1 hr, modification of the dimension statements in the program would enable it to deal with samples which require a longer time to come off the column. The salient features of the rationale of the program are discussed in detail, particularly the procedures for base line correction and for estimating the contributions from components which are not perfectly separated in the column. Examples are given of the program in practice, of comparing the results it gives with those obtained by manual triangulation of the areas on a recorder chart, and of indicating the range of column load over which we have found that it operates satisfactorily. A sample computer print-out from the program is presented and interpreted.


Total nitrogen and L-hydroxyproline content of adipose tissue from various sites in rats of different ages. The total nitrogen and L-hydroxyproline concentrations of two intra-abdominal and two subcutaneous sites of adipose tissue were measured in male and female Wistar rats. At 100 g body weight the nitrogen concentration of intra-abdominal adipose tissue was slightly lower than that of subcutaneous adipose tissue. As age advanced beyond sexual maturity, the nitrogen content of intra-abdominal adipose tissue was steadily reduced, whereas that of subcutaneous tissue did not change. The L-hydroxyproline concentration of intra-abdominal adipose tissue was also lower than in subcutaneous adipose tissue. In male rats it rose in most adipose tissue sites when sexual maturity was reached, then fell with advancing age. In female rats the pattern of change was less consistent, but the l-hydroxyproline content of intra-abdominal adipose tissue was reduced as age increased.


Occurrence of ungulic acid in some epidermal tissues. The lipids isolated from different animal tissues have been studied qualitatively, by TLC, for the occurrence of the ungulic acid fraction. This fraction was found in considerable amounts only in epidermal tissues and its keratinized derivatives. In the present study it was isolated from human keratinous epidermis, hair, and nails, pig bristles, wool, and feathers. The analytical results indicated that a lipid fraction from all of these sources contained ceramide, galactose, galactosamine, sulfate, and sialic acid in equimolar amounts, and that the fractions were similar to the ungulic acid isolated earlier from a horse's hoof.


Sequential enzymes of linoleic acid oxidation in corn germ: lipoxygenase and linoleate hydroperoxide isomerase. Linoleic acid oxidation catalyzed by lipoxygenase (lipoxidase) activity in extracts of defatted corn germ does not terminate in the product, linoleic acid hydroperoxide, unless the lipoxygenase is first partially purified. If purification is not attempted, the hydroperoxide product exists only as a barely detectable intermediate in the synthesis of three products. One of these was identified as 9-hydroxy-10-oxo-cis-12-octadecenoic acid formed from the hydroperoxide by the enzyme, linoleate hydroperoxide isomerase. Another product, 13-hydroxy-10-oxo-trans-11-octadecenoic acid, is believed to be formed by an isomerase also. The third product was the linoleate ester of one of the hydroxy-oxo-fatty acids, 9-(cis-9,cis-12-octadecadienoyl)-10-oxo-cis-12-octadecenoic acid. It is not known if the synthesis of the ester is enzyme-catalyzed. When a mixture of 13-hydroperoxy-cis-9,trans-11-octa-decadienoic acid and 9-hydroperoxy-trans-10,cis-12-octa-decadienoic acid from soybean lipoxygenase oxidation of linoleic acid was used as a substrate, 13-hydroxy-12-oxo-cis-9-octadecenoic acid and 9-hydroxy-12-oxo-trans-10-octadecenoic acid were formed as the major products of catalysis by linoleate hydroperoxide isomerase(s) from corn. Smaller quantities of 9-hydroxy-10-oxo-cis-12-octadecenoic acid and 13-hydroxy-10-oxo-trans-11-octadecenoic acid were also formed.


Evaluation of gel chromatography for plasma lipoprotein fractionation. The fractionation of lipoproteins of normal and hyperlipidemic subjects on a column of 2% agarose was compared with ultracentrifugation and paper electrophoresis procedures. The following results were obtained. (a) Plasma lipoproteins were eluted successively from the column in the four overlapping peaks of chylomicrons, very low density lipoproteins, low density lipoproteins, and high density lipoproteins. (b) Very low density lipoproteins and high density lipoproteins (d > 1.063, containing nonlipoprotein proteins) showed continuous progressive changes in lipid composition as these fractions emerged, while low density lipoproteins showed a relatively constant lipid composition. (c) A discontinuous transition of lipid composition was observed when consecutive ultracentrifugal fractions were placed on the column. (d) The "trail" of pre-beta lipoprotein seen on paper electrophoresis was shown to consist of particles whose molecular sizes range between chylomicrons and pre-beta lipoproteins. A reverse relationship was observed between electrophoretic mobilities of "trail" components and their particle size. (e) Gel with an agarose content of 2% seemed to fractionate chylomicrons and very low density lipoproteins more effectively than other lipoprotein classes.


Glycolipids and other lipid constituents of normal human liver. An analysis of the lipids in normal human liver is presented which is particularly designed to assist in the classification and study of lipid-storage diseases. Special emphasis has been given to a determination of the quantity and composition of the neutral glycolipid classes and predominant ganglioside (Gm(3)). The neutral glycolipid content of 0.19 (sd +/- 0.11) micro moles per g wet tissue, represented 0.4% of the total lipid in liver. Ceramide dihexoside was the most abundant neutral glycolipid. The mean contents of cholesterol, glycerides, and total phospholipids were 3.9, 19.5, and 25.1 mg/g wet weight, respectively. The relative amounts of seven different phospholipid classes were also determined; these included cardiolipin (diphosphatidylglycerol), which constituted 3.9% of the liver phospholipids.


Effect of cellulose in the diet on the recovery of dietary plant sterols from the feces. In one normal subject, J.S., fed several formula diets in a sterol balance study, only 25-58% of the ingested plant sterols were recovered from the stool. The dietary plant sterols were completely recovered from the stools of five other men. Plant sterol recovery was complete in all men when a diet of mixed general foods was consumed. Since the chief differences in composition of the formula and the diet of mixed general foods were related to the different contents of cellulose and lactose, these components were added to the formula diet of J.S., and plant sterol balance studies were then carried out. The addition of fresh celery or pulverized cellulose to the formula diet partially corrected the usual fecal loss of plant sterols (80% being recovered). Lactose in the formula was only slightly corrective. However, the addition of both cellulose and lactose led to complete recovery of the ingested plant sterols in the feces. Bacterial cultures of stools were incubated with added cholesterol-4-(14)C, and a linear relationship between losses of sterol during balance studies and in vitro incubations was observed; that is, a considerable loss of the labeled cholesterol from cultures after the formula diet, but not after the diet of mixed general foods. This in vitro loss was also corrected by the addition of cellulose and lactose to the formula diet. The loss of the sterol nucleus in the intestinal tract may occur at times because of the lack of certain dietary constituents. It is hypothesized that the metabolism of intestinal tract bacteria is altered when certain constituents are not present in the diet, and that these bacteria may then degrade the sterol nucleus.


Isolation and identification of new constituents in milk fat. After removal of cholesterol on a digitonin column, the unsaponifiable matter of milk fat was examined for alcoholic substituents. Derivatization with pyruvic acid chloride 2,6-dinitrophenylhydrazone and fractionation of the derivatives gave four main fractions. The second, the hexane-benzene fraction, was shown by thin-layer chromatography to have a mobility similar to many common sterols. The hexane-benzene fraction was saponified and gave rise to free alcohols, which were then analyzed on a combination gas-liquid chromatograph-mass spectrometer. Dihydrolanosterol, previously unreported in milk fat, and lanosterol, previously identified but never confirmed, were characterized. The sterols which were precipitated on the digitonin column, were removed, and by the use of the combination gas-liquid chromatograph-mass spectrometer beta-sitosterol was identified. In addition, lanosterol and dihydrolanosterol were isolated from the unsaponifiable matter by chromatography on Florisil.


Separation of sterols by vapor-programmed thin-layer chromatography. By vapor-programmed thin-layer chromatography on silica gel, it was possible to separate cholestanol from cholesterol and stigmastanol from beta-sitosterol. The method was applied for the analysis of beta-sitosterol-3-(14)C.


Thin-layer chromatography of tissue lipids without extraction. Frozen tissue sections were applied directly to silica gel plates, and the lipids were separated by developing the plates in different solvent systems. Quantitation of the lipid classes was achieved by direct transmission densitometry after the plates were treated with a chromic acid-sulfuric acid spray.


Separation by gel chromatography of naturally occurring phosphatidylcholine mixtures according to number of ethylenic linkages. This paper describes a procedure for the separation of lecithins according to the number of ethylenic bonds in their fatty acid residues. The procedure uses a column of alkylated dextran (Sephadex LH-20) eluted with an organic solvent system, the unsaturated lipids being separated as their mercuric acetate addition compounds. The system is capable of resolving at least four species of lecithin, and the intact lecithin molecules can be recovered for further study. The chromatographic system has been tested with lecithin derived from dog lung, rat liver, and hen's egg.


Personality correlates of the undergraduate volunteer subject.


Taxonomic classification of male delinquents from autobiographical data and subsequent recidivism.


Sex differences in the use of hostile verbs.


An evaluation of psychotherapy at a community mental health center.


Manifest anxiety and academic achievement of American and Canadian college freshmen.


Time perception for helicopter vibration and noise patterns.


Some limiting factors in reciprocal inhibition therapy.


Attitudes of schizophrenic children about parents and others in their environments: a semantic differential study.


The outcome of group psychotherapy in a group used for teaching.


On the theory of community psychiatry.

On the theory of community psychiatry.


Paralogic involvement of the notion of awareness in schizophrenic thinking.


On administrative psychiatry.

On administrative psychiatry.


Communty mental health--an underview.

Communty mental health--an underview.


The oxygen cycle.

The oxygen cycle.


The carbon cycle.

The carbon cycle.


The nitrogen cycle.

The nitrogen cycle.


Mineral cycles.

Mineral cycles.


Human food production as a process in the biosere.


Human energy production as a process in the biosphere.


Intelligence and race.

Intelligence and race.


Calcitonin.

Calcitonin.


Visual cells.

Visual cells.


Guidelines for the design of laboratory surveys.


Systematic versus random error in laboratory surveys.


Suggested definitions for clinical laboratory standards and reference materials.


A revised scheme for the comparison of quantitative methods.


Multiphasic screening by laboratory tests--an overview of the problem.


The 1949 College of American Pathologists survey revisited.


Cyanmethemoglobin certification program of the College of American Pathologists.


The 1969 survey of prothrombin time.

The 1969 survey of prothrombin time.


Computed normal values for peak acid output based on age, sex and body weight.


Effect of caerulein on histamine and pentagastrin-induced gastric secretion in man.


Zinc and collagen content of cirrhotic liver.


Very high levels of SGOT and LDH in patients with extrahepatic biliary tract obstruction.


Isolated bleeding from colonic varices in patients with liver diseases.


Acute granulomatous disease of the liver.


Tetracycline-associated fatty liver in the male. Report of an autopsied case.


Congenital short esophagus in the newborn.


Desquamative interstitial pneumonia. An electron microscopic study.


Effectors of cellular immunity. Introduction.


Lymphocyte--target cell interaction in vitro. Ultrastructural and cinematographic studies.


Glycogen and phosphorylase activity in rat brain during recovery from several forms of hypoxia.


Migration inhibitory factor and the cellular basis of delayed-type hypersensitivity reactions.


Mechanisms of lymphocyte-induced cell and tissue destruction in vitro.


Products of lymphoid cells in continuous culture.


The use of botany in pathology.

The use of botany in pathology.


Studies of an inhibitor of DNA synthesis and a nonspecific mitogen elaborated by human lymphoblasts.


Histopathology of amino acid deficiencies. IX. The ultrastructure of the Leydig cells of rats receiving lysine-deficient or hypocaloric diets.


A bronchial carcinoid having low serotonin concentration.


Malignant atrophic papulosis with mucin in the dermis. A clinical and pathological study, including autopsy.


Hemorrhagic pericarditis in uremia. Clinicopathologic studies in six patients.


Lipoma of the liver.

Lipoma of the liver.


The pathologic anatomy of Ebstein's disease.


Induction, histogenesis, and isotransplanta bility of renal tumors induced by formic acid 2-[4-(5-nitro-2-furyl)-2-triazolyl]-hydrazide in rats.


Definition of a continuous human cell line derived from neuroblastoma.


Mouse mammary tumor metastases in lung: an electron microscopic study.


Comparative effects of the antitumor agents 5-(Dimethyltriazeno)-imidazole-4-carboxamide and 1,3-bis(2-chloroethyl)-1-nitrosourea on cell cycle of L1210 leukemia cells in vivo.


Association of decreased uridine and deoxycytidine kinase with enhanced RNA and DNA polymerase in mouse leukemic cells resistant to 5-azacytidine and 5-aza-2'-deoxycytidine.


Effects of 4,4'-diacetyldiphenylurea-bis-(guanylhydrazone) on the incorporation of precursors into nucleic acid and protein of leukemia L1210.


Rat ferritin isoproteins and their response to iron administration in a series of hepatic tumors and in normal and regenerating liver.


Radiation dose-independent inactivation of isologous mouse lymphoma cells by nonspecific resistance.


Effects of dietary fat and dose level of 7,12-dimethylbenz(alpha)-anthracene on mammary tumor incidence in rats.


Delayed hypersensitivity and neoplasia: in vitro studies with macrophage migration.


Invasive tumors induced in rats with actinomycin D.


Interaction of aflatoxins B1 and G1 with tissues of the rat.


Loosening of total hip replacements with cement fixation. Clinical findings and laboratory studies.


Total prosthetic replacement in rapidly destructive arthrosis of the hip joint.


Total replacement of the hip.

Total replacement of the hip.


Total replacement of the hip by the McKee-Farrar prosthesis. A preliminary report of 81 cases.


Total hip replacement with the McKee prosthesis. A study of 121 follow-up cases using neutral cement.


Urist hip socket and Moore prosthesis without cement for hip replacement.


McKee-Farrar total replacement of the hip joint in rheumatoid arthritis and allied conditions.


Total hip replacement.

Total hip replacement.


Preliminary report on total hip joint replacement with Urist-Thompson unit without cement.


A new splint for balanced suspension.

A new splint for balanced suspension.


Total hip replacement using McBride cup and the Moore prosthesis.


Total hip replacement without cement. McBride acetabular component and Moore femoral prosthesis.


Hip motion measurements for selected activities of daily living.


Prosthetic arthroplasty in the treatment of degenerative arthritis of the hip.


Evaluation of cold-curing acrylic cement for prosthesis stabilization.


Developmental (infantile) coxa vara--a distinct entity. Report of two patients with previously normal roentgenograms.


Power instrumentation for cup arthroplasty.


Low-friction arthroplasty of the hip in rheumatoid arthritis and ankylosing spondylitis.


Implant acceptance in the musculoskeletal system.


Holding power of orthopedic screws in bone.


Impending Volkmann's contracture following minor trauma to the palm of the hand. A theory of pathogenesis.


Extraosseous placement of guide wire for blind stabilization of the proximal femur.


Instruments to facilitate precision application of bone plates.


Present application of the Darrach procedure.


Tennis elbow: diagnosis, pathology and treatment. Nine severe cases treated by a new reconstructive operation.


Effects of mechanical forces on growing cartilage.


Tibial shaft fractures: percutaneous multiple pin fixation, short-leg cast and immediate weight bearing.


Arthropuncture technic.

Arthropuncture technic.


Studies on bone turnover and balance in the rabbit. II. Effects of fluoride.


Dysplasia epiphysealis multiplex.

Dysplasia epiphysealis multiplex.


Studies on bone turnover and balance in the rabbit. I. Effects of hydrocortisone.


Complications in total hip replacement with the Charnley technic.


Studies on bone turnover and balance in the rabbit. 3. Effects of hydrocortisone plus fluoride.


Total prosthetic replacement of the hip joint in Auckland.


Low-friction total hip replacement. Advantages and pitfalls.


Total hip prostheses.

Total hip prostheses.


Total hip replacement with rotation-endoprosthesis. [Trunnion-bearing prosthesis].


Ischemic diseases of the bowel. I. Ischemia of the small bowel.


Total hip replacement by low-friction arthroplasty.


Modification of the Charnley artificial hip joint.


Development of total prosthetic replacement of the hip.


Electrokinetic surfaces of trypsin-dissociated embryonic chick liver cells.


Regional histone changes in embryos of the newt, Triturus pyrrhogaster, during early development.


Changes of the "radioresistant" thymic lymphocyte population following x-irradiation of mice.


Site of action of 1-methyladenine in inducing oocyte maturation in starfish.


Ischemic diseases of the bowel. IV. Roentgenographic findings.


Effect of isoproterenol on ribonuclease activity of salivary glands.


Ischemic diseases of the bowel. II. Ischemic colitis.


Electron microscopy of human fibroblasts in tissue culture during logarithmic and confluent stages of growth.


Ischemic diseases of the bowel. 3. Physiology of the bowel.


Synchronization of DNA synthesis in Tetrahymena populations by temporary limitation of access to thymine compounds.


Independent synchronization of DNA synthesis and of cell division in same culture of Tetrahymena cells. Demonstration that heat-shock induced division-synchrony is by differential extension of the G2 phase.


Staging of colonic and rectal carcinomas: a review of ten years' experience at a private hospital.


Cancer of the rectum: an analysis of 171 patients in a community hospital.


Studies on in vitro lymphocyte proliferation in cultures synchronized by the inhibition of DNA synthesis. II. Kinetics of the initiation of the proliferative response.


Induction of glutamine synthetase in embryonic retina. Effects of partial and complete inhibition of RNA synthesis on enzyme accumulation.


Pilonidal disease.

Pilonidal disease.


Multiple cancers of the large bowel.

Multiple cancers of the large bowel.


Carcinoma metastatic to the vermiform appendix: report of three cases.


Necrotizing proctitis caused by injection of barium into the wall of the rectum: report of a case.


Dissociation studies on the 80 S ribosome from Pisum sativum.


Long-range electrostatic interactions between amoebae and anion-exchange particles.


Glycosidase activity. Glycosidase acitivity in L5178Y mouse leukemic cells and the activity of acid phosphatase, beta-galactosidase and beta-N-acetylgalactosaminidase and beta-N-acetylglucosaminidase in a synchronous L5178Y cell population.


Cavernous hemangioma of the rectum: an unusual case.


Visualization of ribosomes by freeze-etching.


Growth and differentiation of lepidopteran myoblasts in vitro.


Uptake of isolated metaphase chromosomes by mammalian cells in vitro.


Electron microscopy of DNA in pea chloroplasts.


In vitro studies with RNA polymerase. Detection of structural changes in formalin-fixed L cell nuclei at different stages of growth.


Activation of transcription in vitro from chromatin by non-histone proteins.


Expression of constitutive heterochromatin in cultured fibroblasts from Microtus agrestis.


Pinocytosis in centrifuged and bisected amoebae.


Isoenzyme stability in human heteroploid cell lines.


Toxicity of sulfhydryl compounds to cultured human lymphocytes.


Microassay for cathepsin D shows an unexpected effedt of cycloheximide on limb-bone rudiments in organ culture.


Fluorescent staining of heteropycnotic chromosome regions in human interphase nuclei.


Identification of the abnormal B group chromosome in the "cri du chat" syndrome by QM-fluorescence.


Quinacrine mustard-fluorescence of human chromosomes 4, 5 and X.


Poorly differentiated subendothelial cells in swine aortas.


Studies on hepatic protein synthesis in rats force-fed a threonine-devoid diet.


Cytoplasmic ribonucleic acid synthesis in the prereplicative phase of isoproterenol-induced cell proliferation.


Role of the pericyte in wound healing. An ultrastructural study.


Studies on the secretory and cytotoxic actions of caffeine on the ferret gastric mucosa.


Chlorpromazine and the eye of the dog. An electron microscopic study.


Coccidiosis: general method of analysis for field experiments.


Coccidiosis: coccidiostat evaluation under field conditions.


Coccidiosis: problems arising from the development of anticoccidial drug resistance.


Coccidiosis: experimental analysis of drug resistance.


Anticoccidial drugs: screening methods.

Anticoccidial drugs: screening methods.


Coccidiosis: criteria used and problems involved in changing coccidiostats in a commercial operation.


Coccidiosis: development of new techniques in coccidiostat evaluation.


Coccidiosis: summary of evaluation and selection of coccidiostats.


Coccidiosis: selection of the most useful parameters for anticoccidial drug testing.


Poultry anticoccidial agents: survey of parameters for evaluation.


Anticoccidial drugs: objectives of symposium on development, selection, and testing.


Coccidiosis: evaluation of coccidiostats by mortality, weight gains, and fecal scores.


Anticoccidial drugs: lesion scoring techniques in battery and floor-pen experiments with chickens.


Coccidiosis: evaluation of techniques for battery testing of field-collected Eimeria oocysts.


Coccidiosis: introduction to design and execution of floor-pen experiments.


Coccidiosis: evaluation of anticoccidial drugs in floor-pen trials.


Coccidiosis: experimental design considerations for evaluating anticoccidial agents in floor-pen and field trials.


Avian Eimeria infection technique: suspended seeder cage.


Coccidiosis: wxperimental designs involving drug mixtures.


Coccidiosis: evaluations of coccidiostats under field conditions; statement of problems.


Coccidiosis: problems in recognition in field operations.


Coccidiosis: oocyst counting technique for coccidiostat evaluation.


Gastroenterology: physical events in lipid digestion and absorption. Introductory remarks.


Surface and bulk interactions of lipids and water with a classification of biologically active lipids based on these interactions.


Measurement of the size of micelles: the case of sodium taurodeoxycholate.


Adrenergic receptors mediating metabolic responses. Introductory remarks.


Mechanistic studies of solute transport rates at oil-water interface.


Adrenergic receptors for metabolic effects in muscle.


Adrenergic receptors for metabolic responses in the heart.


Adrenergic receptors for catecholamine effects on tissue electrolytes.


Biochemical mechanisms involved in regeneration. Introductory remarks.


Control of DNA synthesis in regenerating liver.


Pancreas acinar cell regeneration. VII. Phosphate content of nuclear histones during pancreas degeneration and regeneration.


Induction of DNA synthesis by a purified chemical compound.


Changes in chromosomal proteins at times of gene activation.


Role of iron in the regulation of ferritin metabolism.


Compensatory cardiovascular responses during an environmental cold stress, 5 degrees C.


Chemical parameters in the study of in vivo and in vitro interactions of transition elements.


Distribution of pulmonary blood flow and ventilation during forward (plus Gx) acceleration.


Some aspects of nutritional trace element research.


Dependence of oxygen consumption on circulation in normovolemic and hypovolemic dogs.


Effects of hypoxia on voluntary response time to peripherally loca ted visual stimuli.


Energy metabolism, body size, and problems of scaling.


Relation of structure to energy coupling in rat liver mitochondria.


Serum electrolyte changes after marathon running.


Cardiovascular dimensions and moderate physical training in young men.


Rhythmic variations in energy metabolism.


Exercise at ambient and high oxygen pressure at high altitude and at sea level.


Metabolic oscillations in lipid metabolism in rats on controlled feeding schedules.


Nutrition and nerve cell growth.

Nutrition and nerve cell growth.


Nutrition and cell development. Introduction.


Resistance to two-phase gas-liquid flow in airways.


Muscle and liver cell growth: role of hormones and nutritional factors.


Metabolic regulation in relation to cell development.


Polyamine changes during development of Drosophila melanogaster.


Cellularity of obese and nonobese human adipose tissue.


Effect of vagal blockade on regulation of breathing in conscious dogs.


Regional dispersion of volume-to-ventilation ratios in the lung of man.


Stratified dead space in excised perfused lungs.


Polyamines and the accumulation of RNA in mammalian systems.


Effect of food and water deprivation on surface activity of lungs of rats.


Generation of sinusoidal fluid pressures of relatively high frequency.


A direct photosensor technique to measure capillary blood cell motion.


A simple and rapid method for selectively altering plasma cation concentration.


Hand-held device to measure finger (thumb) strenght.


Lung models: hollow, flexible reproductions.


Error analysis of a recording system for measuring pulmonary pressure-volume curves.


A real-time waveform analyzer for detection of ventricular premature beats.


Aerosol laryngography and bronchography.


Benign, cystic posterior mediastinal teratoma.


Idiopathic juvenile osteoporosis.

Idiopathic juvenile osteoporosis.


A new projection for demonstrating the sigmoid colon.


Infarction of colon with ulceration simulating granulomatous colitis.


Extramedullary plasmacytoma of the colon.


The use of sorbitol in the investigation of the small bowel.


Pendant mammography: a new approach to an old technique.


Hydrops of the gallbladder: unusual roentgenographic demonstration.


An unusual abdominal mass in an infant--a case for diagnosis.


Extravasation of contrast material during excretory pyelography.


Absence of translational control of histone synthesis during the HeLa cell life cycle. The cell-free synthesis of histone-like polypeptides has been achieved using a selected class of small polyribosomes as the only particulate fraction. This synthesis is prevented if the deoxyribonucleic acid (DNA) inhibitor, cytosine arabinoside, is added to the cells prior to disruption, and it is not detected when the cytoplasm used is derived from postmitotic (G(1)) cells. When the 100,000 g supernate from pure metaphase populations was compared with that from S phase cells, the cell-free synthesis of histone-like polypeptides in the presence of S phase polyribosomes remained unchanged. These data suggest that, except for the histone messenger RNA-ribosome complex, the cytoplasmic factors requisite for histone synthesis are present throughout the cycle, and that the shut-off of this synthesis is not under translational control.


Undamped oscillations of pyridine nucleotide and oxygen tension in chemostat cultures of Klebsiella aerogenes. Klebsiella aerogenes was grown in chemostat culture with the pH controlled to +/-0.01 and temperature to +/-0.1 degrees C. The oxygen tension of the culture was regulated by changing the partial pressure of oxygen in the gas phase and recorded by means of an oxygen electrode. Reduced pyridine nucleotide was monitored continuously in the culture by means of direct fluorimetry. On applying an anaerobic shock to the culture, damped oscillations in pyridine nucleotide fluorescence were obtained. Further anaerobic shocks decreased the damping and eventually gave rise to undamped oscillations of a 2-3 min period which continued for several days. These oscillations were paralleled by oscillations of the same frequency in respiration rate. The amplitude of the oscillations in the respiration rate was equivalent to only 1% of the total steady-state respiration, whereas that of pyridine nucleotide oscillations was equivalent to 10% of the total aerobic/anaerobic fluorescence response. The oscillations ceased on interrupting the glucose feed but restarted on adding excess glucose to the culture. Addition of succinate also restarted the oscillations so that they appear not to be of glycolytic origin. The frequency of oscillations varied with growth rate and conditions. Oscillations of much lower frequency were obtained under limited-oxygen and anaerobic conditions than under fully aerobic conditions. Under glucose-limited conditions, fluctuations were found in adenosine triphosphate (ATP) content which were in phase with the pyridine nucleotide oscillations, but under nitrogen-limited growth conditions no such fluctuations in ATP were observed. The primary oscillating pathway could not be identified but the mechanism would appear to be quite different from that involved in oscillations observed in yeast cells. The synchronization of oscillations and observations of negative damping could be explained by a syntalysis effect.


A large scale quasi-crystalline lamellar lattice in chloroplasts of the green alga Zygnema. A quasi-crystalline lamellar lattice was observed in chloroplasts of the filamentous green alga Zygnema. The lattice does not appear in the cells until cultures are at the end of the log phase of growth. Pseudograna are also present and become more numerous towards the middle of the log phase. The three-dimensional lattice superficially resembles the configuration of cubic prolamellar bodies but is about 10 times larger and is entirely different in internal structure. The lattice is composed of one or two appressed thylakoids in a stroma matrix which is bounded on each side by a single thylakoid membrane. This multilayered sandwich of membranes and matrix occupies a position equivalent to the single membrane of a cubic prolamellar body.