Mechanism of mitral regurgitation in hypertrophic obstructive cardiomyopathy. Echocardiography of the mitral valve in patients with hypertrophic obstructive cardiomyopathy has revealed an abnormal pattern of movement. The abnormality is characteristic, readily recognized, and can be explained in anatomical and physiological terms. It consists of a sharp reopening of the valve during systole when it should normally remain in the fully closed position. This abnormal movement mirrors the mid-systolic onset of both outflow tract obstruction and mitral regurgitation. It was only absent in the two patients with the disease in whom both mitral regurgitation and outflow tract obstruction were also absent. A second and less striking abnormality was a reduced diastolic closure similar to that seen in mitral stenosis and attributed to slow left ventricular filling. The echo from the septum is also unduly prominent.


Effects of propranolol on response to exercise in hypertrophic obstructive cardiomyopathy. The circulatory, respiratory, and metabolic responses to steady state submaximal exercise have been studied in four women and two men with hypertrophic obstructive cardiomyopathy, before treatment, after intravenous, and after three months of oral propranolol. The physical working capacity was significantly lower than in normal subjects, and the response to exercise was characterized by a tachycardia, low cardiac output and stroke volume, and high ventilation and blood lactate concentration. After propranolol there was a significant reduction in heart rate, but changes in most other measurements were slight and there was no improvement in effort tolerance though angina was relieved in the two patients in whom it was present. The possible causes of breathlessness and effort intolerance in hypertrophic obstructive cardiomyopathy are discussed in relation to known effects of propranolol. It is concluded that further trial of propranolol and other beta-adrenergic blocking agents is warranted.


A case of fatal peri-partum cardiomyopathy. A case of fatal cardiomyopathy presenting in the puerperium is described. Despite extensive investigation and post-mortem examination no aetiological factor was found. The diagnosis of specific peri-partum cardiomyopathy is discussed.


Insulin resistance and thrombocytopenic purpura occurring in the same patient.


Cat leukemia.

Cat leukemia.


Sleepwalking and guilt.

Sleepwalking and guilt.


Cat leukaemia.

Cat leukaemia.


Foot-and-mouth disease.

Foot-and-mouth disease.


Purification and properties of catechol 1,2-oxygenase from Trichosporon cutaneum.


Stricture and dilatatio of the esophagus in the cat.


Imperforate cardiac septal defect in a dog.


Dextroaorta, atopic left subclavian artery, and persistent left cephalic vena cava in a dog.


Ringworm of the horse caused by an atypical form of Microsporum canis.


Infectious tenosynovitis in cattle.

Infectious tenosynovitis in cattle.


Ectopic cilia of the canine eyelid.

Ectopic cilia of the canine eyelid.


The estimation of daily faecal trypsin levels in dogs as an indicator of gross pancreatic exocrine insufficiency.


Arthritis and osteo-arthritis in dogs.

Arthritis and osteo-arthritis in dogs.


Surgical repair of an ununited fracture of the fibular tarsal bone of a miniature poodle.


Letter to the editor: Endotracheal tube radio-opaque marker misdiagnosed as a tracheal foreign body.


Determination of predator food preferences.


Initiation of slime mold aggregation viewed as an instability.


Asymmetry of living systems.

Asymmetry of living systems.


Karyotypic fissioning and canid phylogeny.


Aggression in animals.

Aggression in animals.


Aggression in horses.

Aggression in horses.


Selective spinal cord arteriography in cord compression by tumour.


Application of angiography to tumours affecting the spinal cord.


Heterologous bovine liver perfusion therapy of acute hepatic failure.


Angiocardiography in canine heartworm disease.


Prepatent clinical, pathologic, and serologic changes in dogs infected with Dirofilaria immitis and treated with diethylcarbamazine.


Experimentally induced Angiostrongylus cantonensis infection in dogs.


Cap cell hyperplasia of the meninges in a wildebeest.


Efficacy of pyrantel tartrate as an anthelmintic in swine.


Some factors that influence egg hatch of Aedes aegypti (Diptera: Culicidae).


Comparative effects of chemosterilants on spermatogenic stages in the house fly. II. Recovery of fertility and sperm transfer in successive matings after sterilization with 1,3-propanediol dimethanesulfonate or x-rays.


Glutaminase from pig renal cortex. II. Activation by inorganic and organic anions.


Carboxymethylation of sperm whale myoglobin in the dissolved state.


High resolution proton magnetic resonance studies of cyanoferrimyoglobins and alkylated derivatives from different species.


Formation from trypsin and modified soybean trypsin inhibitor of a complex which upon kinetic control dissociation yields trypsin and virgin inhibitor.


Effect of salts on inhibition of chicken muscle adenosine monophosphate deaminase by phosphate esters and inorganic phosphate. Effect of 5,5'-dithiobis(2-nitrobenzoic acid)on enzyme activity and inhibition by 2,3-diphosphoglyceric acid.


A program for control of drug abuse in industry.


An overview of occupational health nursing in an era of change.


The electron microscope in biomedical research.


Nursing education programs.

Nursing education programs.


President's message.

President's message.


Locomotor disturbance of cattle grazing Halogeton glomeratus.


Linoleate oxidation induced by lipoxygenase and heme proteins: a direct spectrophotometric assay.


Occurrence of Mima and Herellea species in clinical specimens from various animals.


Congestive heart failure in the cat.

Congestive heart failure in the cat.


Rickets and osteodystophia fibrosa in foxes fed a high horsemeat ration.


Brief to the commission of inquiry into non-medical use of drugs.


[An electron microscopic study of the rat prostate, with special reference to the effect of hypophysectomy. II. The fine structure of hypophysectomized rat prostate].


Cryobiology: the freezing of biological systems.


Study of TV violence: seven top researchers blackballed from panel.


Paecilomyces clavisporis sp. nov., Trichoderma saturnisporum sp. nov., and other noteworthy soil fungi from Georgia.


DNA synthesis in autonomous and hormone-responsive mammary tumors.


Biological and technical aspects of nucleic acid synthesis in cultures of mammary tumors.


News rom the National Communicable Disease Center. Leptospirosis, 1965-1968.


Ecology and attempted control of cutaneous leishmaniasis around Jericho, in the Jordan Valley.


Electrographic and behavioral effects of diazepam during alcohol withdrawal stage in cats.


A chemically defined medium for the study of growth, sporulation, and presumptive sporogenic substances in Alternaria tomato.


An electron microscope study of deoxyribonucleoprotamines.


Quantitative relationship between amount of dietary fat and severity of alcoholic fatty liver.


Variation of electrolyte content in wet-spun lithium- and sodium-DNA.


Selective measurement of the synthesis and metabolic stability of messenger RNA in 3T3 mouse cells.


Biosynthetic studies with carbon-13; variotin.


Advantages of integrating sterile-male releases with other methods of control against house flies.


Oviposition and hatchability of eggs of the face fly.


Autochemosterilization of the southern house mosquito by means of a modified light trap.


Comparison of urinary pregnanediol with plasma progesterone levels to detect ovulation.


Unequal cojoint goat twin.

Unequal cojoint goat twin.


Coexistent aortic and subaortic stenosis.


Ultrasonic attenuation measurements in phospholipid dispersions.


The subunits of thyroglobulin.

The subunits of thyroglobulin. 1. Pig thyroglobulin was reduced with dithiothreitol in the presence of sodium dodecyl sulphate, 8m-urea or 6m-guanidinium chloride. 2. The molecular weights of the reduction products were about 165000. 3. Two stable subunits with molecular weights as low as 35000 and 20000 were separated by Sephadex chromatography after prolonged exposure of the reduction products to sodium dodecyl sulphate at pH8.7. Although a hydrolytic reaction is probably implicated, the nature of the chemical linkages broken was not established.


Observations by nuclear magnetic resonance of the interactions of water with lecithin micelles in carbon tetrachloride solution.


Selective effect of domiphen bromide (dodecyldimethyl(2-phenoxyethyl)ammonium bromide) on some hydrolytic enzymes.


Isolation of a phospholipase a from Agkistrodon piscivorus venom.


Developmental patterns of drug metabolism in liver and in some non-hepatic tissues of fetal and newborn rabbits.


Immunological aspects of the binding of substrate analogues and polypeptide inhibitors to alpha-chymotrypsin.


Effects of some psychoactive drugs on experimental "neurotic" (conflict induced) behavior in cats.


Blood concentrations of acetaldehyde and ethanol in chronic alcoholics. Fifteen adult male alcoholic volunteers were studied before, during, and after a 10- to 15-day period of experimentally induced intoxication. Blood acetaldehyde concentrations ranged from 0.11 to 0.15 and from 0.04 to 0.08 milligrams per 100 milliliters when blood ethanol concentrations ranged from 1 to 400 milligrams per 100 milliliters after consumption of bourbon or grain ethanol, respectively. No dose or dose-time relationships were found between blood ethanol concentrations and blood acetaldehyde concentrations during any phase of this study.


Chlorinated hydrocarbon insecticides: root uptake versus vapor contamination of soybean foliage. The major environmental source of DDT (dichlorodiphenyltrichlo-roethane) residues in soybean plants arises from vapor movement from contaminated soil surfaces. In contrast, the presence of dieldrin, endrin, and heptachlor results primarily from root uptake and translocation through stems to leaves and seeds.


Inhibition of cytotoxicity of lymphocytes by concanavalin A in vitro. Human lymphocytes treated with the plant protein concanavalin A are stimulated to transform into blasts, without developing cytotoxicity for chicken erythrocytes. Prior treatment of lymphocytes with concanavalin A potentiated phytohemagglutinin-induced blast transformation and DNA synthesis but completely inhibited phytohemagglutinin-induced cytotoxicity. Inhibiton was not due to suppression of the mixed lymphocyte-erythrocyte aggregation normally caused by phytohemagglutinin. Inhibition of cytotoxicity was reversible when concanavalin A was removed from the lymphocytes by treatment with methyl-alpha-D-manno-pyranoside after 1 hour but not after 20 hours. The results indicate that blast transformation and cytotoxicity are separate expressions of lymphocyte stimulation.


Failure of mestranol alone or with norethynodrel to prepare for the generalized Shwartzman reaction in rats.


Normal lactation and blood growth hormone studies.


Genetic and interracial aspects of hypertensive toxemia of pregnancy. A prospective study.


Placental oxygen consumption in vitro. V. Hypertensive disorders.


Reliability of fetal blood sampling. Maternal-fetal relationships.


The human element--a problem in psychiatric assessment.


Schizophrenia--does the prognosis make a difference?


Ocular leprosy in Malawi. Clinical and therapeutic survey of 8,325 leprosy patients.


Estimation of sodium fusidate levels in human serum, aqueous humour, and vitreous body.


Ocular findings in thrombotic thrombocytopenic purpura (Moschcowitz's disease).


Hemothorax: a rare complication of splenoportography.


Serum osmolality and plasma electrolytes in patients who develop dilutional hyponatremia during transurethral resection.


Feline viruses. V. Serum-neutralization test for feline panleukopenia.


Antibody response before and after abortion in psittacosis (Chlamydia) infections in pregnant cows.


Ram epididymitis. A study on infertility.


Feline viruses. VI. Survey of the incidence of feline pathogenic agents in normal and clinically-ill cats.


Swine abscesses caused by Lancefield's group E streptococci. VI. Experimental application of hemagglutination tests for their detection.


Preovulatory changes in the progesterone level of bovine peripheral blood plasma.


Mycoplasma infections of goats.

Mycoplasma infections of goats.


Testicular phospholipids. II. Action of interstitial cell-stimulating hormone (ICSH) upon testicular phospholipids in hypophysectomized rats.


Progesterone: regulation of estrous cycle, ovulion and estrous behavior in the golden hamster.


Effect of continuous light and darkness on hydroxyindole-0-methyltransferase and 5-hydroxytryptophan decarboxylase activities in the Japanese quail.


Reporting communicable animal diseases.

Reporting communicable animal diseases.


Bovine viral diarrhea-mucosal disease, abortion, and congenital cerebellar hypoplasia in a dairy herd.


Surgical correction of a thoracic abscess in a colt.


Clinical and radiologic survey of canine panosteitis.


A procedure for the surgical removal of dirofilaria immitis.


Incidence of microfilariasis in dogs in Detroit, Michigan.


Sympathicoblastoma in a dog.

Sympathicoblastoma in a dog.


Adenocarcinoma of the thyroid gland in a cat.


Chemotactic effect of Staphylococcus aureus on neutrophils isolated from the bovine mammary gland.


Liver lipids of lactating bovine: fatty acid composition.


Methionine hydroxy analog: varying levels for lactating cows.


Limitations and possible side effects of virus vaccines.


Psychophysiological correlation of 17-ketosteroids and 17-hydroxycorticosteroids in 21 pairs of monozygotic twins.


Management of thermal burns with Sulfamylon.


Communicating in writing. I.

Communicating in writing. I.


Good communication can reduce your company's lost time.


Write right.

Write right.


The taking of minutes.

The taking of minutes.


Tissue reactions to Schistosoma mansoni eggs. II. Distribution of eggs in faeces and at different levels of the intestinal wall, at variable intervals after infection.


Plasmodium (Sauramoeba) giganteum in Agama cyanogaster: a new host record.


A malaria-like parasite of a bat from Brazil.


Trypanosoma vivax in ruminants.

Trypanosoma vivax in ruminants.


Herpetomonas oestrorum--a parasite within a parasite.


An unusual site for a ciliate in the blue wildebeeste (Connochaetes taurinus).


Development of the hook in Onchocerca volvulus.


Two remarkable nematodes from a South American tortoise.


Cytotaxonomy.

Cytotaxonomy.


A new species of the Anopheles punctulatus complex.


Phlebotomus longipes from Ethiopia.

Phlebotomus longipes from Ethiopia.


Typing of fresh or stored cells by absorption of lymphocytotoxic antibodies.


Embryonic development of human transplantation antigens.


Human immune response to a xenogeneic nucleated cell.


The ethics of certain surgical procedures in the dog.


Cheyletiella yasguri: widespread infestation in a breeding kennel.


Hairball in the pig.

Hairball in the pig.


Feline haemobartonellosis.

Feline haemobartonellosis.


The sedation of cattle.

The sedation of cattle.


The relationship between the total lactation yields of heifers and the yields of the halves of their udders.


Observations on the effect of introducing salmonella-infected calves to a commercial beef rearing unit.


Growth of weaned lambs at pasture.

Growth of weaned lambs at pasture.


Treatment of dilatation and right abomasal displacement in cattle by pyloroplasty or pyloromyotomy.


A knackery survey of calf disease.

A knackery survey of calf disease.


A post-mortem x-ray study of laminitis in barley beef animals.


Bovine mastitis associated with Mycobacterium smegmatis and an untypable Mycobacterium.


Dissecting aneurysm of the aorta in a gorilla.


Spraying of streets with toxic substances.


Salmonella give infection in cattle.

Salmonella give infection in cattle.


A technique for blood sampling the chicken from the jugular vein.


Nutrition of the dairy heifer.

Nutrition of the dairy heifer.


Amino acid differences between highly cross-reactive antibodies.


Fluorine magnetic resonance study of the interaction of serum albumin with 8,8,8-trifluorooctylbenzene-p-sulfonate ions.


Reversible boundary spreading as a criterion of the microheterogeneity of plasma albumins.


Multioscillator fluorescence depolarization. Anisotropy of dye binding.


Yeast pyruvate kinase. Native and subunit molecular weight.


Gel filtration, aggregation, and the enzymatic activity of glycogen phosphorylase.


Dissociation and association of the oligomeric forms of factor V.


Polar lipids in bovine milk. II. Long-chain bases, normal and 2-hydroxy fatty acids, and isomeric cis and trans monoenoic fatty acids in the sphingolipids.


A new saccharogenic micromethod for measurement of amylase activity in biological fluids.


Angioarchitecture of the sigmoid flexure of the bovine corpus cavernosum penis and its significance in erection.


Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme.


A conformational study of porcine thyrocalcitonin.


Lipid, bile acid, water and dry matter content of the intestinal tract of domestic ducks with reference to the habitat of Polymorphus minutus (Acanthocephala).


Influence of sucrose on chloroquine-3-H3 content of mammalian cells in vitro: the possible role of lysosomes in chloroquine resistance.


Uterine weight and pituitary LH content in the pseudopregnant hamster.


Quantitative changes in uterine nucleic acids during the oestrous cycle in rats.


Effect of gamma-chlordane on synchronized lymphoma cells and inhibition of cell division.


Learning impairment associated with maternal phenylketonuria in rats.


Effects of radiation on asynchronous and synchronized L cells under energy deprivation.


Electric power production--another public health dilemma.


Bilirubin excretion in newborn human infants. I. Unconjugated bilirubin as a possible trigger for bilirubin conjugation.


Vietnam casualties.

Vietnam casualties.


Relationship between fallout and trends in infant and fetal mortality.


A big city strives for relevance in its community health services.


Policing publicly funded health care for poor quality, overutilization, and fraud--the New York City Medicaid experience.


Comparative demographic profiles: voluntary and paid blood donors.


Identifying and developing health services in a new town.


Evolution of a health program: the Job Corps experience.


Dentistry, legislation, and the new administration.


Dentistry's role in Regional Medical Programs.


Some new dimensions of social work practice in a health setting.


Changing the patterns of ambulatory pediatric caretaking: an action-oriented training program for nurses.


An effect of continued exposure to air pollution on the incidence of chronic childhood allergic disease.


Fatal phenol poisoning from improperly laundered diapers.


An investigation of the effectiveness of a new helmet to control touch football head injuries.


Current status of population research in schools of public health.


Salmonella excretion in joy-riding pigs.


Interprofessional education in law and the health sciences.


Cultivation of hepatic tissue from chimpanzees  experimentally infected with adenovirus.


Alternatives to the suicide prevention approach to mental health.


The effect of moderate hyperthermia on canine bladder.


Induction of ovulation in sheep by electrical stimulation of hypothalamic regions.


The blood levels of oxytocin during machine milking in cows with some observations on its half-life in the circulation.


Tube agglutination test of Mycoplasma hyopneumoniae infection in swine.


Estrous cycle and age in mice of DSD strain affected with endometrial cystic hyperplasia.


Shark oil and medicine.

Shark oil and medicine.


Renal clearance of estriol in complicated pregnancies.


Osteochondrosis of the vertebrae in a dog.


Biochemical aspects of an outbreak of bovine polioencephalomalacia.


Toxic reactions in cattle treated with systemic organophosphate insecticides.


Problems of antlerogesis.

Problems of antlerogesis.


Cleavage of the fourth component of human complement (C4) by activated Cls.


Regions of high and low cationic charge in a lysine-rich histone.


Measurement of rubella antibody by hemagglutination inhibition. I. Variables affecting rubella hemagglutination.


Effect of anesthesia and amputation on tumor and general immunity of the mouse.


More on mollies (and tetracycline).

More on mollies (and tetracycline).


A study of clinical, pathological, and electroencephalographic features in 137 full-term babies with a long-term follow-up.


The effect of a high dose of adrenalin and noradrenalin upon visual evoked response (VER) and electroretinogram (ERG).


Development of rhythmic processes.

Development of rhythmic processes.


Studies on psychophysiologic individuality.


Influence of 1.4-benzdiazepin on stress in rats.


Interindividual differences in reactivity to stress in selected rats.


Transplacental passage of pesticides.

Transplacental passage of pesticides.


Effect of pregnancy and hypertension on reticuloendothelial activity.


Effect of intrauterine transfusion on the maternal urinary estrogen excretion.


Vascular degenerative changes in the uterine arteries and veins of multiparous rats.


Quantitative evaluation of effects of exogenous amines on contractility of human myometrium in vitro.


Evaluation of fetal scalp pH with a proposed new clinical assessment of the neonate.


Granuloma formation around Schistosoma mansoni, S. HAEMATOBIUM, AND S. japonicum eggs. Size and rate of development, cellular composition, cross-sensitivity, and rate of egg destruction.


Aggression reconsidered.

Aggression reconsidered.


Angiosarcoma of the skull. Report of a case and review of the literature.


A systematic sex difference in intestinal carcinoma.


Reaction of glyoxal with alpha-glucan phosphorylases from potato and rabbit muscle.


Effects of cyproterone acetate on aggressive behaviour and the seminal vesicles of male mice.


Estimation of the minimum amount of luteinizing hormone secreted for ovulation in rats.


Effects of excess dietary phenylalanine on composition of cerebral lipids.


Ejaculatory reflex and luteal activity induction in Mus musculus.


Effects of intense noise during fetal life upon postnatal adaptability (statistical study of the reactions of babies to aircraft noise).


The role of estrogen in the control of the estrus cycle in the ewe.


Pituitary content of follicle-stimulating hormone in the female rat.


LH release, ovulation and estrus following the  treatment of anoestrous ewes with ovarian steroids.


Identification of antemortem and postmortem blood (report) 1.


Studies on the alimentary flora of pig. V. Influence of starvation on the microbial flora.


Canine pulmonary disease and the urban environment. I. The validity of radiographic examination for estimating the prevalence of pulmonary disease.


Epizootology supplements epidemiology.

Epizootology supplements epidemiology.


Canine pulmonary disease. II. Retrospective radiographic analysis of pulmonary disease in rural and urban dogs.


Differential effect of porcine proinsulin on rat epididymal fat cells and fat pieces.


Effect of alkylbenzenesulfonate as a vehicle for 4-nitroquinoline 1-oxide on gastric carcinogenesis in rats.


Initial stage of hematogenous metastasis of Cr-labeled tumor cells.


"Nine-position-test" for proof of even illumination of the light field in fluorescence microspectrophotometry.


The reliability of neurons.

The reliability of neurons. The prevalent probabilistic view is virtually untestable; it remains a plausible belief. The cases usually cited can not be taken as evidence for it. Several grounds for this conclusion are developed. Three issues are distinguished in an attempt to clarify a murky debate: (a) the utility of probabilistic methods in data reduction, (b) the value of models that assume indeterminacy, and (c) the validity of the inference that the nervous system is largely indeterministic at the neuronal level. No exception is taken to the first two; the second is a private heuristic question. The third is the issue to which the assertion in the first two sentences is addressed. Of the two kinds of uncertainty, statistical mechanical (= practical unpredictability) as in a gas, and Heisenbergian indeterminancy, the first certainly exists, the second is moot at the neuronal level. It would contribute to discussion to recognize that neurons perform with a degree of reliability. Although unreliability is difficult to establish, to say nothing of measure, evidence that some neurons have a high degree of reliability, in both connections and activity is increasing greatly. An example is given from sternarchine electric fish.


Fluorinated pyrimidines. XXXVII. Effects of 5-trifluoromethyl-2'-deoxyuridine on the synthesis of deoxyribonucleic acid of mammalian cells in culture.


Red cell flexibility and electrical resistance of blood centrifuged at low g-values.


Psychiatric symptoms in community, clinic, and mental hospital groups.


The HL-A antigen, KN-HN (=HL-A13).

The HL-A antigen, KN-HN (=HL-A13).


Contributions of psychiatric epidemiology.


Marihuana psychosis.

Marihuana psychosis.


Isolation of nucleotides, nucleic acids, and protein from single tissue samples by a phenol technique.


5-Thyminyl-5,6-dihydrothymine from DNA irradiated with ultraviolet light.


Modification by sucrose of the catalytic activity and physical properties of glutamic dehydrogenase.


Intermediate fragments of the newly replicated DNA in mammalian cells.


Alterations in proteins and polyamino acids caused by ultraviolet irradiation in a spectropolarimeter.


4-Hydroxypyrazolo (3,4-d) pyrimidine as a substrate for xanthine oxidase: loss of conventional substrate activity with catalytic cycling of the enzyme.


Crosslinking during the nitration of bovine insulin with tetranitromethane.


Induction of phenylalanine ammonia lyase and pisatin in pea pods by poly-lysine, spermidine or histone fractions.


Evidence for the presence of a protein-bound intermediate in the cleavage and the synthesis of glycine.


A general method for the isolation of labelled peptides from affinity-labelled proteins.


Free-flow electrophoresis: a new method for the elucidation of immunological events at the cellular level, II. The formation of 19S hemolysin-producing cells in intestinal lymph nodes of the rat.


A kHz dual wavelength spectrophotometer. Design and experimental test.


Differentiation of normal and malignant cells.


Some considerations for evaluating the Doman-Delacto "patterning" method.


The effects of an intracoronary infusion of adenosine on cardiac performance, blood supply and on myocardial metabolism in dogs.


Investigations into the fluctuations of proprioceptive reflexes in man. I. Fluctuations of the patellar tendon reflex and their relation to the vegetative rhythms during spontaneous respiration.


Investigations into the fluctuations of proprioceptive reflexes in man. II. Fluctuations of the patellar tendon reflex and their relation to vegetative rhythms during controlled respiration.


Effect of Amiloride on sodium transport of frog skin. I. Action on intracellular sodium content.


Preferences for morphine in rats: validation of an experimental model of dependence.


The effect of pilocarpine in combination with monoamine oxidase inhibitors, imipramine or desmethylimipramine on oestrous behaviour in female rats.


Ambulatory paediatrics in a teaching hospital.


Spleen effluent manipulations: some biologic possibilities.


Effect of progesterone on length of estrous cycle in cattle.


Visceral larva migrans (Toxocara canis) in calves.


Spectral studies on the deoxyribonucleic acid-aflatoxin B1 system. Binding interactions.


Cholelithiasis in a cat.

Cholelithiasis in a cat.


Side-chain conformation of 5 alpha 17 alpha-pregnan-20 alpha- and 20 beta-ols: a nuclear magnetic resonance study.


Proein-synthetic activity of ribosomes from interferon-treated cells. Cell-free protein-synthetic systems from normal and interferon-treated chick cells were compared. No difference was found in the amino acid incorporation activities of such ribosome-cell sap systems or in their response to polyuridylic acid. Throughout a variety of experiments we failed to detect the formation of a discrete peak of virus-specific polysomes, when ribosome monomers and subunits (from interferon-treated or control cells) were incubated with labeled Sindbis or Semliki Forest virus ribonucleic acid (RNA). Some binding of viral RNA did occur, but the complexes formed were evident in sucrose gradients as a broad, rapidly sedimenting shoulder on the ribosome monomer peak. Interferon pretreatment of cells did not affect the formation of these complexes in vitro, nor did it alter their rate of breakdown on incubation under amino acid incorporation conditions. Experiments with inhibitors of protein synthesis showed that such "breakdown" was not dependent upon amino acid incorporation and was not an index of translation. In these respects, our results are in marked contrast to those of Marcus and Salb. These results, together with our failure to detect any significant change in the protein composition of ribosomes from interferon-treated cells, suggest that such treatment does not result in a modification of the ribosome per se. They do not, however, rule out the involvement of a factor(s) required for ribosomes and viral RNA to function in viral protein synthesis. Indeed, it remains likely that interferon acts through such a mechanism, although the precise level at which the inhibition occurs remains to be elucidated.


Circadian rhythm for experimentally-induced aggressive behavior in mice.


Population crisis and extremism.

Population crisis and extremism.


On the apparent homology of actin and tubulin. Muscle actin and ciliary A-tubulin from Pecten irradians have molecular weights of 46,000 and 59,000, respectively, as measured by sodium lauryl sulfate-polyacrylamide-gel electrophoresis. Tryptic and chymotryptic peptides obtained from these proteins are very dissimilar, indicating that there is little significant homology.


Congenital ectodermal dysplasia in male miniature poodle siblings.


Metabolism of the obligatory aerobic yeast Rhodotorula gracilis. II. Pyruvate kinase and phosphoenolpyruvate carboxykinase activities at various metabolic states.


Chemical and physical characterization of ovomucin, a sulfated glycoprotein complex from chicken eggs.


Murine catalase phenotypes.

Murine catalase phenotypes.


Microheterogeneity in ferritin molecules.


The NH2-terminal amino acid of bovine prothrombin.


The isolation of undegraded bovine prothrombin and its partial characterization.


Physical properties of mouse H-2 transplantation alloantigens.


Fetal mammary gland differentiation in vitro in response to hormones. I. Morphological findings.


Cellular interaction and chondrogenesis in vitro.


Fetal mammary gland differentiation in vitro in response to hormones. II. Biochemical findings.


DNA polymerase from rat liver chromosomal proteins. Alteration of template specificity and alkaline deoxyribonuclease activity.


Horse liver alcohol dehydrogenase. On the primary structure of the ethanol-active isoenzyme.


Subcellular responses to localized infection of Chenopodium quinoa by pokeweed mosaic virus.


Chromosomal localization of mouse satellite DNA. Hybridization of radioactive nucleic acids with the DNA of cytological preparations shows that the sequences of mouse satellite DNA are located in the centromeric heterochromatin of the mouse chromosomes. Other types of heterochromatin in the cytological preparations do not contain satellite DNA.


Antigen-induced blastogenesis: the human cell determining the specificity of response in vitro.


The relative rates of synthesis of hemoglobins A and F in immature red cells of newborn infants.


Congenital bacterial pneumonia with intact fetal membranes.


Neonatal hypocalcemia in low birth weight infants.


Antenatal infection and unruptured membranes.


Infants of diabetic mothers.

Infants of diabetic mothers.


Methotrexate in the treatment of choriocarcinoma.


Progestins in the medical management of active acromegaly.


Intra-uterine contraceptive device with ectopic gestation. A case report.


Violence as a defense against intimacy.

Violence as a defense against intimacy.


Ovotransferrin with one iron atom.

Ovotransferrin with one iron atom.


Drug ads on tv and radio.

Drug ads on tv and radio.


Electrocardiography and vectorcardiography in idiopathic hypertrophic subaortic stenosis.


Aggressive behavior in the rat: effects of isolation, and olfactory bulb lesions.


A new Indian source of diosgenin (Costus speciosus).


Acceleration of the rate limiting step in norepinephrine biosynthesis by potassium.


Primary antibody response in mice bearing leukemia L1210.


Ethical confusion, medicine and the law.


The effects of parental consanguinity and inbreeding in Hirado, Japan. I. Stillbirths and prereproductive mortality.


Rabbit uterine contractile activity increase following coitus.


Suprapublic trocar cystostomy.

Suprapublic trocar cystostomy.


The vascular stiffening mechanism in t tongue of the echidna (Tachyglossus aculeatus).


Transarterial diffusion of mepivacaine.

Transarterial diffusion of mepivacaine.


Study of tuberculosis amongst cattle in Calcutta.


Variation in calving interval in Tharparkar, Hariana and Malvi cows.


Some observations on trichomoniasis of the upper digestive tract of love birds (Budgerigars) in Hyderabad, Andhra Pradesh.


Occurrence of twin chick embryos.

Occurrence of twin chick embryos.


Effect of body weight at birth of the Murrah buffaloes on their milk yield and period of different lactations.


Quixalin (Squibb) in the treatment of bovine coccidiosis.


Amaurosis in dog--a case report.

Amaurosis in dog--a case report.


A case of trigeminal paralysis in dog.

A case of trigeminal paralysis in dog.


Selective renal arteriography in renal tumors. Malign tumors.


H-1 virus growth in synchronized rat embryo cells.


Observation on the influence of changing photoperiod on spontaneous wheel-running activity of neonatally pinealectomized rats.


Composition of the cell wall of Pityrosporum ovale (Bizzozero) Castellani and Chalmers.


Dogs need more than meat.

Dogs need more than meat.


Madura mycosis with secondary proteus infection. A case report.


Long-term oxygen cage therapy for hypoxemic dogs.


Torsion of the left apical and cardiac pulmonary lobes in a dog.


Radiographic contrast techniques for detecting orbital and nasolacrimal tumors in dogs.


Prostatic cyst.

Prostatic cyst.


Familial renal disease in Norwegian Elkhound dogs.


A psammous meningioma in a dog.

A psammous meningioma in a dog.


Longer rabies quarantines?

Longer rabies quarantines?


Alleviation of hip dysplasia with bilateral excision arthroplasty.


Enthusiasm generates prosperity in Iowa.


Induced estrus as an aid in detection of bovine genital vibrosis by means of the virgin heifer test.


Prosthesis for partially amputated foreleg in a horse.


Intra-articular injection of betamethasone in arthritis in horses.


Dislocation of the humerus. Diagnosis.

Dislocation of the humerus. Diagnosis.


Formylation of iron (3) porphyrins and chlorins of natural origin.


Components of Chionographis japonica Maxim. IV. Structures of chiograsterone and isochiograsterone, two new sterols from Chionographis japonica Maxim.


New metabolites of gibberella fujikuroi. XIV. O-demethyl-anhydrofusarubin.


The utility of superoxide dismutase in studying free radical reactions. II. The mechanism of the mediation of cytochrome c reduction by a variety of electron carriers.


Novel heterocyclic spirobenzofurans.

Novel heterocyclic spirobenzofurans.


Studies on the formation and association characteristics of IgG class antibodies in bovine serum and colostrum against protein antigens.


Hemangioblastoma of the cerebellum associated with erythrocytosis and an unusual blood supply. Case report.


Looks like meat, tastes like meat, costs less.


Variant of group B lacking the B antigen on the red cells.


On the genetic interpretation of the 6-phosphogluconate-dehydrogenase-isozymes in man.


Changes upon fertilization in the distribution of RNA-containing particles in sea urchin eggs.


DNA synthesis and development in reciprocal interordinal hybrids of a sea urchin and a sand dollar.


Comparison of effects of hypophysectomy, antiserum to ovine LH, and ovariectomy on estrogen secretion during the rat estrous cycle.


Ionizing radiation as a source of veterinary malpractice and negligence actions.


Long-standing unilateral contraction of the diaphragm synchronous with the heart beat.


Retinopathy in anemic cats.

Retinopathy in anemic cats.


Osteochondromatosis in a cat.

Osteochondromatosis in a cat.


Human gait and the human foot: an ethnological study of flatfoot. II.


Diagnosis of feed-related toxicoses.

Diagnosis of feed-related toxicoses.


Necropsy of the bovine paralytic.

Necropsy of the bovine paralytic.


Lead and organic pesticide poisonings in cattle.


Rabies in Illinois farm animals.

Rabies in Illinois farm animals.


Diagnosis of lightning strike.

Diagnosis of lightning strike.


Foreign bodies.

Foreign bodies.


Characterization of a nonproteolytic arginine ester-hydrolyzing enzyme from snake venom.


Conformation of the phosphoprotein, phosvitin.


Bovine liver flutamate dehydrogenase. Sequence of a hexadecapeptide containing a lysyl residue reactive with pyridoxal 5'-phosphate.


Properties of thyroglobulin. XX. The biosynthesis of thyroglobulin. Effect of temperature on subunit species.


Ichthyosarcotoxism--Ciguatera intoxication.


Occurrence of warble fly, Hypoderma lineatum, infestation in yaks in Bhutan.


Mechanism of action of thiosinamine, an egg suppressive agent in schistosomiasis.


Effect of amprolium on Eimeria adenoeides in cell culture.


Bovine filariasis in Dinajpur District, East Pakistan.


The spermatozoon of Arthropoda. VII. Plecoptera and Trichoptera.


Ultrastructure of a new cell in the gills of the air-breathing fish Helostoma temmincki.


Lentysine: a new hypolipidemic agent from a mushroom.


Studies on microsomal cytochrome P-450 in resistant and susceptible houseflies.


Pheromones and their effect on aggression in mice.


Protean displays as inducers of conflict.


Evidence against transmission of scrapie by animal house fomites.


Agricultural pest control and the environment.


Amphetamine: differentiation by d and l isomers of behavior involving brain norepinephrine or dopamine. d-Amphetamine is markedly more potent an inhibitor of catecholamine uptake by norepinephrine neurons in the brain than is 1-amphetamine, whereas the two isomers are equally active in inhibiting catecholamine uptake by the dopamine neurons of the corpus striatum. In behavioral studies, d-amphetamine is ten times as potent as 1-amphetamine in enhancing locomotor activity, while it is only twice as potent in eliciting a compulsive gnawing syndrome. This suggests that the locomotor stimulation induced by amphetamine involves central norepinephrine, while dopamine neurons play an important role in the induced compulsive gnawing behavior. Assessment of differential actions of d- and 1-amphetamine may be an efficient method to differentiate behaviors involving norepinephrine or dopamine in the brain.


Collection of blood samples and smears for diagnosis.


The slender thread.

The slender thread.


An experimental study of the effects of growth on the relationship of tendons and ligaments to bone at the site of diaphyseal insertion. 3. Autoradiographic study with 3H-thymidine of the insertion area of the tendon of the pectineus muscle.


Innovations in a pediatric unit.

Innovations in a pediatric unit.


A discussion of the oxygen effect based upon the two-component theory of radiation.


Ectopic pregnancy in Nairobi, Kenya.

Ectopic pregnancy in Nairobi, Kenya.


Oxygen tension of oral cavity carcinoma.


Current concepts of surgical treatment of anorectal fistula.


Standardization of a hemagglutination test for schistosomiasis with formalin-treated human erythrocytes.


Thelazia callipaeda Railliet and Henry, 1910, in man and dog in Thailand.


Ecologic studies of Buttonwillow virus in Kern County, California, 1961-1968.


Directed assembly of polypeptis of the isozymes of lactate dehydrogenase.


Age changes in the polymer composition of acid soluble collagen prepared from rat tail tendon.


The effect of diet on the composition of chromatin from young and old rats.


Acetylcholine metabolism peculiarities in aging.


A fluorescent compound in collagen and its relation to the age of the animal.


Cytotoxic activity of imidazole derivatives.


The use of anticollagenic serum in experiment on rabbits of various age.


Observations on smooth muscle disposition in the urinary tract.


Thermal requirements to protect aquatic life in texas reservoirs.


Toxicological aspects of wastewater reclamation--a preliminary report.


Bedside differentiation of heart murmurs.


Schistosoma mansoni: alteration in ovipositing capacity by transplanting between heterologous hosts.


Histomonas meleagridis: effect on plasma enzymes in chickens and turkeys.


Sperm distribution and degradation in the human female reproductive tract. In 26 fertile women studied 25-41 hours after coitus the presence of uterine sperm directly correlated with the density of sperm in the cervical mucus and the hormonal phase of the woman's menstrual cycle.  All patients in whom uterine sperm were found at hysterectomy had a cervical mucus sperm density of at least 10/hpf when examined 24 hours before.  All were probably in the late proliferative phase or within the period of up to 36 hours after ovulation.  In all mammals, following ejaculation most spermatozoa remain in the vaginal cavity.  They are subjected primarily to the vaginal fluids and phagocytic cells during the process of degradation.  This study confirms a previous hypothesis that from 5 days before ovulation through 2 days after ovulation is the optimal pregnancy period.


Results with the Cendehill rubella vaccine in postpartum women.


Cervical pregnancy: review of the literature and a case report.


Lithium-induced changes in electrolyte balance and tissue electrolyte concentration.


Cochleo-saccular degeneration in Hedlund white mink.


Aggressive behaviour in chicks induced by tricyclic antidepressants.


Fetuses and newborns of 95 per cent pancreatectomized female rats.


Early versus late feeding of low birth weight neonates--a controlled study.


An anthropometric study of the newborn in Varanasi.


A study of complement fixation, agglutination and haemagglutination tests in bovine brucellosis.


Studies on the pathology of female reproductive organs of Indian buffalo. Occurrence of rete ovarii and cystadenoma.


Gastric carcinoma in equines.

Gastric carcinoma in equines.


Genetic and phenotypic studies of lactation yield and lactation length in Gir cattle.


Incidence of goiter in goats.

Incidence of goiter in goats.


Brassica sp. (Sarson) plant poisoning in a group of Haryana heifers.


Bovine trypanosomiasis--control with 'Samorin'.


Left bundle branch block.

Left bundle branch block.


Binding of long chain fatty acids to beta-lactoglobulin.


C-terminal amino-acid sequence of bovine immunoglobulin light chain.


Amino-acid sequence of slightly lysine-rich histone.


Comparison of the effects of LSD, heliotrine and x-irradiation on chromosome breakage, and the effects of LSD on the rate of cell division.


Radiation resistance and sensitivity of mice transferred by foster nursing.


Biology of African elephants.

Biology of African elephants.


Pediatric facial trauma.

Pediatric facial trauma.


Transurethral resection of bladder-neck tumours.


Thrombocytopenic purpura following Mantoux test.


Alkaline phosphatases in normal and malignant tissues.


Some facts concerning the epizootiology of trichinellosis in Spain.


Complex epidemiologic and epizootiologic studies in foci of trichinellosis.


The epidemiology and control of trichinellosis in the United States.


An attempt of using some serologic methods in the diagnosis of trichinellosis in slaughter pigs.


A construction improvement of the installation "OFR" for trichinelloscopy.


Epizootiological and epidemiological problems of trichinellosis in Latvian S.S.R.


A differential diagnostics of Trichinella spiralis larvae during the microscopic examination of muscles of animals.


Trichinellosis of animals in Georgia.

Trichinellosis of animals in Georgia.


The importance of trichinellosis in Hungary.


Education for health services administration. IV. Perceptual differences of administrators regarding the importance of health service programs. Implicaions for education for health services administration.


Epidemiological data for mental health center pnning. I. Field survey methods in ocial psychiatry: the problem of the lost population.


Epidemiological data for mental health center planning. 3. Demographic factors and responses to stress among rural people.


Group practice and poor communities.

Group practice and poor communities.


An associate of arts program for training mental health associates.


Preeminence and mortality: longevity of prominent men.


Prevention of cardiovascular diseases.

Prevention of cardiovascular diseases.


Contraceptive methods prior to hospital discharge: the first city-wide program.


Guidelines for the control of rabies.

Guidelines for the control of rabies.


Health planning agencies.

Health planning agencies.


The health administrator.

The health administrator.


The New Left and American public health--attempted radicalization of the A.P.H.A. through dialectic.


Education for health services administration. 1. Undergraduate training for health administration.


Education for health services administration. 3. The influence of system thry in educating health services administrators. The University of California experience.


Education for health services administration. II. Community planning for new partnerships i health administration.


An investigation of the conformation of bovine alpha-lactalbumin by proton magnetic resonance and optical spectroscopy.


Influenza and mumps diagnostic antigens from BHK-21 cell cultures.


Prepation of hypercholesterolemic and-or hypertriglyceridemic sera for lipid determinations.


Immunochemical studies on hen's egg-white lysozyme. The role of the lysine, the histidine and the methionine residues.


Polykaryocyte induction by Newcastle disease virus propagated on different hosts.


Tubules of globoid leukodystrophy: a right-handed helix. Morphologic similarity between the cytoplasmic tubules of globoid leukodystrophy and Gaucher's disease (as demonstrated by thin sectioning, negative staining, and shadowing techniques) and their resemblance to negatively stained beef cerebroside are presented as evidence favoring the accumulation of cerebrosides in globoid cells. The tubules of globoid leukodystrophy have a 60-angstrom periodic banding similar to the tubules of Gaucher's disease. A right-handed helical twisting of the tubules is observed in both diseases.


Carac glycosides and distastefulness: some observations on the palatability spectrum of butterflies. The monarch butterfly Danaus plexippus sequesters cardiac gylcosides from northern species of Asclepias formerly reported to lack these noxious compounds. Thus, a new explanation must be sought as to why the monarchs reared on these northern asclepiads are palatable to avian predators.


Large-quantity production of chicken embryo tracheal organ cultures and use in virus and mycoplasma studies. Chicken tracheal organ cultures were made from embryos which were 19 to 20 days old. Transversely cut rings of trachea were placed in screw-capped tissue-culture tubes with Eagle's-N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) medium and incubated in roller drums. The method had advantages over other organ culture systems in that these cultures were prepared in numbers similar to conventional tissue cultures, ciliary activity was quickly and accurately evaluated, and contamination occurred less frequently than with organ cultures in petri dishes. Ciliary activity persisted for at least 1 month when the medium was changed at 5-to 7-day intervals and for 10 to 15 days without a change. Infectious bronchitis virus stopped ciliary movement, and this effect was used as a basis for titrating the virus and for determining the neutralizing capacity of immune mouse ascitic fluid. Twenty-four Mycoplasma strains were tested. Organisms of 17 strains, both avian and mammalian, multiplied in the organ cultures, and 7 strains, belonging to the species M. gallisepticum and M. mycoides var. capri, inhibited ciliary activity.


Salmonella enteritidis serotype 50-1,2,3: Z4, Z24:-. Characteristics of a new Salmonella serotype, subgenus IV, are reported. Culture 5534-68 was recovered from the intestinal tract of Anolis biporcatus, an arboreal lizard found in deep forest tracts in Panama Province, Republic of Panama. The antigenic composition of this new serotype was found to be 50(1, 2, 3):z(4), z(24):-.


Inactivation of bovine thrombin by nitrous acid.


Purification of Neurospora crassa endonuclease-resistant DNA-RNA hybrid.


Tumor cell metabolism in vitro: a study of incubation media.


Endrin poisoning in chickens.

Endrin poisoning in chickens.


Human fascioliasis in Malawi.

Human fascioliasis in Malawi.


Hygromas in cattle.

Hygromas in cattle.


Spastic diplegia after short gestation.

Spastic diplegia after short gestation.


Some aspects of the nonagenarian's environment.


Anorexia nervosa in one of identical twins.


The role of splenectomy in neonatal idiopathic thrombocytopenic purpura.


Congenital anomalies in the pig: teratogenic effects of trypan blue.


Heat production and thermoregulation in the small-for-date infant.


The role of the neonatologist.

The role of the neonatologist.


Prenatal influences upon small-for-date infants: an introduction.


Occurrence of unique colloidal particles in snake blood and their transport across the capillary wall. A proposal of a new hypothesis on the permeability of the blood capillaries.


The fine structure of the subcommissural organ of the human fetus.


Studies on the metabolic products of Oospora astringenes. 8. Isolation, chemical structure, and biosynthesis of oospolide.


Studies on the centrally acting muscle relaxants: the spinal reflex and the spinal gamma-aminobutyric acid level in young chickens.


Peyer's patches: immunologic studies.

Peyer's patches: immunologic studies. The immune capabilities of the Peyer's patches have been investigated by the use of an in vitro system. Despite our failure to stimulate Peyer's patch lymphocytes in vivo it appears that Peyer's patches behave immunologically as peripheral lymphoid tissues. Cultures prepared from the dissociated Peyer's patches of normal rabbits respond to sheep erythrocytes. The response is comparable to that obtained with spleen cultures from the same animals and is not dependent on the presence of the epithelial cells which line the lumen. Similar thymic cultures do not respond. Our experiments with cultures prepared from rabbits which have received one or two injections of SRC show that the Peyer's patches contain both IgM and IgG "memory" cells which have migrated from the spleen. The concentration of these cells in the spleen remains several hundredfold higher.


Maturation of hemolysin-producing cell clones. II. The appearance and localization of precursor units in lymphoid tissues of neonatal mice. Cells capable of reacting with sheep erythrocyte (SRBC) antigen to maturate and produce hemolysin appear simultaneously in the bone marrow and spleen of 1-day old Swiss-Webster mice. However, hemolysin-producing cell clones (HPCC) do not result. Complete functional precursor units generally appear in the spleens of mice older than 3 days. In vivo and in vitro data correlate well in this regard. Complete precursor units are not seen in the bone marrow and only very rarely in the thymus. The efficiency of precursor units of neonatal mice when they become functional approximates that of the mature animal when based on the doubling time of plaque-forming cells (PFC). Possible explanations of the initial appearance of incomplete precursor units have been discussed.


Studies on the specificity and affinity of alpha, DNP-oligolysine antibody: a basis for questioning the role of cell-bound antibody in cellular recognition of antigen.


Effect of physical state and route of inoculation of diphtheria toxoid on the formation of nasal secretory and serum antibodies in man.


Concanavalin A: a reagent for sensitization of erythrocytes with glycoproteins and polysaccharides.


Homocytotropic antibody in primary responder and hyperimmune rabbits.


Phenylketonuria and glutamine.

Phenylketonuria and glutamine.


Histidinemia.

Histidinemia.


Propionate utilization by pregnant, lactating, and spontaneously ketotic dairy cows.


Oxytocin levels in the plasma of Holstein-Friesian cows during milking with and without a premilking stimulus.


Anatomical traits as they relate to productive utility.


Observations on rumen fluid, blood serum, and milk lipids of cows fed methionine hydroxy analog.


Do twins carry a high risk for mother and baby?


Immunocytes and autoimmune response and suppression.


The structure of bostrycin.

The structure of bostrycin.


Some characteristics of streptococci competent for uptake of deoxyribonucleic acid.


Temperature-induced orientation instability during meiosis: an experimental analysis.


A massive system of microtubules associated with cytoplasmic movement in telotrophic ovarioles.


Antibody-mediated suppression of the immune response in vitro. I. Evidence for a central effect. Antibody-mediated suppression of the in vitro immune response to polymerized flagellin of Salmonella adelaide and to sheep erythrocytes was studied at the cellular level. Normal mouse spleen cells, preincubated in vitro with mixtures of antigen and antibody for short periods of time before being washed, did not respond to an optimal antigenic challenge in vitro, whereas similar cells treated with antibody alone gave a normal response. The degree of immune suppression was found to depend on the time of preincubation. Significant immune suppression could be induced in as short a time as 15 min, whereas profound suppression (90%) required the incubation of cells with mixtures of antigen and antibody for 4-6 hr. Mouse spleen cells treated similarly were also unable to respond subsequently to the antigen upon transfer to lethally irradiated hosts, as measured at both the level of the antigen-reactive cell and that of serum antibody production. These results were taken as evidence that in vitro an effect of antibody-mediated suppression occurred at the level of the immunocompetent cell. Similarities between immune tolerance and antibody-mediated suppression in vitro were described, and the significance of the findings discussed in the light of current concepts of the mechanism of antibody-mediated suppression.


Time: an important variable at Caesarean section.


Cerebral vascular disease in pregnancy. I. Haemorrhage.


Fetal haemoglobin in cord blood as estimated by two different techniques.


An analysis of massive pulmonary haemorrhage in the newborn infant in Oxford, 1948-68.


The racecourse medical officer.

The racecourse medical officer.


Electron microscopy of cells infected with Semliki forest virus temperature-sensitive mutants: correlation of ultrastructural and physiological observations. Cells infected at the permissive temperature with three temperature-sensitive mutants of Semliki Forest virus were not significantly different in appearance from cells infected, at either the permissive or nonpermissive temperature, with wild-type virus. Virus particles, nucleocapsids, spherules, and tubules were seen in the cytoplasm. But replication of the mutants was inhibited in cells infected at the nonpermissive temperature. This was evidenced by the absence of virus particles and nucleocapsids (except in one case) and the absence or limited production of spherules and tubules. These observations are discussed with reference to the physiological defects of the mutants.


The induction of oestrus in mares by uterine infusion of saline.


Rumenitis containing Fusiformis necrophorus organisms found in a calf reared on an early weaning feeding system.


The British Veterinary Association-Kennel Club progressive retinal atrophy scheme.


The use of magnesium alloy bullets.

The use of magnesium alloy bullets.


A case of uterine prolapse in a donkey.

A case of uterine prolapse in a donkey.


Plasma insulin, glucose, and cortisol levels during and after exchange transfusion.


Topography of nucleic acid helices in solutions. The interaction specificities of optically active amino acid derivatives. The synthesis and interactions of the d- and l-enantiomers of the amino acid amide derivatives [Formula: see text] (I) and lysyl dipeptides [Formula: see text] (II) with poly rI.poly rC, poly rA.poly rU and calf thymus DNA is reported. The following results were found. (1) The degree of stabilization of the helices as measured by the T(m) (;melting' temperature) of the helix-coil transition was dependent on the nature of the amino acid. (2) For the poly rI.poly rC helix, the l-enantiomers of salts (I) and (II) stabilized more than the d-enantiomers. The same was true for calf thymus DNA in the presence of salts (II) and for poly rA.poly rU in the presence of salts (II) and the proline derivatives of salts (I). (3) As R increased in size and became more apolar, the amount of stabilization of the poly rI.poly rC helix in the presence of salts (I) decreased. On the other hand, the amount of stabilization increased with more polar substituents. An attempt was then made to determine whether the difference in stabilization of the double-stranded helices at the T(m) in the presence of the l- and d-enantiomers of salts (I) is due to the interaction with the helix, the random coil or both. A new method was developed for determining the binding of small ions to polyions that involves a competition between an insoluble polystyrene ion-exchange resin and the soluble polyion for the counterion. Dissociation constants are obtained for the complexes of single- and double-stranded helices with the salts (I). The results are illuminating and indicate that with certain helices, i.e. poly rA.poly rU, the interactions of salts (I) with the single strands may not be ignored. It is concluded that the high optical specificity found in Nature, i.e. d-ribose in nucleic acids and l-amino acids in proteins, cannot be attributed solely to monomer-polymer interactions described by Gabbay (1968).


Preparation and characterization of antigen and antibody adsorbents covalently coupled to an inorganic carrier. Immunoadsorbents were prepared by the use of an inorganic carrier. The proteins were covalently coupled to the carrier through a silane coupling agent. An immunoadsorbent prepared with human gamma-globulin was found to complex with specific antibodies. These antibodies could be recovered in high yield and purity from the adsorbent. Similarly, insolubilized antibodies to l-asparaginase were used to isolate and purify the enzyme from crude extracts. These insolubilized antibodies are extremely stable with time and may be reused many times.


Study of the thermal denaturation of ribonuclease A by differential thermal analysis and susceptibility to proteolysis. 1. The thermally induced change in conformation of ribonuclease A in solution was investigated by differential thermal analysis and the susceptibility of the enzyme to proteolytic digestion by ficin. 2. A transition with a mid-point of 60.5 degrees C at pH4.2 was observed directly by differential thermal analysis and shown to be a property of the native structure. 3. At pH4.2 ribonuclease A is susceptible to ficin digestion at 60 degrees C but not at 18 degrees C. 4. Chromatographic analysis of the digestion products reveals that transient active intermediates are produced during the digestion. 5. Three of these intermediates were purified and partially characterized. 6. The nature of those sections of the ribonuclease molecule that are involved in the thermal transition is discussed.


Bovine brain creatine phosphotransferase: amino acid sequence around the essential thiol groups.


Effect of phenylalanine on protein synthesis in the developing rat brain. 1. Inhibition of the rate of incorporation of [(35)S]methionine into protein by phenylalanine was more effective in 18-day-old than in 8-day-old or adult rat brain. 2. Among the subcellular fractions incorporation of [(35)S]methionine into myelin proteins was most inhibited in 18-day-old rat brain. 3. Transport of [(35)S]methionine and [(14)C]leucine into the brain acid-soluble pool was significantly decreased in 18-day-old rats by phenylalanine (2mg/g body wt.). The decrease of the two amino acids in the acid-soluble pool equalled the inhibition of their rate of incorporation into the protein. 4. Under identical conditions, entry of [(14)C]glycine into the brain acid-soluble pool and incorporation into protein and uptake of [(14)C]acetate into lipid was not affected by phenylalanine. 5. It is proposed that decreased myelin synthesis seen in hyperphenylalaninaemia or phenylketonuria may be due to alteration of the free amino acid pool in the brain during the vulnerable period of brain development. Amyelination may be one of many causes of mental retardation seen in phenylketonuria.


The uptake of glycerol ethers by the lactating goat mammary gland.


Mixed lipolytic activities of an enzyme preparation from the pancreas.


Uterine response to adrenergic nerve stimulation in the guinea-pig.


Effects of circulating oestrogen on function of the cholinergic dilator nerves supplying the guinea-pig uterine artery.


The brain acetylcholine system in barbitone-dependent and withdrawn rats.


Laboratory experiments suitable for practical classes in psychopharmacology.


Urethral pressure measurement: a modified technique.


Hazard from the home aquarium.

Hazard from the home aquarium.


Agriculture and the public health.

Agriculture and the public health.


Influence of in vivo aging of rabbit spermatozoa caused by infrequent collection on fertility and embryonic mortality.


Potassium, phosphorus and calcium interrelationships influencing feedlot performance and phosphatic urolithiasis in lambs.


Genetic consequences of crossbreeding.

Genetic consequences of crossbreeding.


Effects of cyclopropane and xenon upon the high-resolution nuclear magnetic resonance spectrum of ferrimyoglobin cyanide.


Control of estrus and ovulation in the pig by ICI 33828 and gonadotropins.


Radiocytogenetic determination of the oxygen enhancement ratio of californium 252.


Association of an enlarged tentorial artery with cerebellar hemangioblastoma. A case report.


Dose-rate effects for various dose rates of 252Cf radiation on HeLa cells in culture.


Species-dependent inhibition of platelet aggregation by adenosine and dipyridamole: paradoxical potentiation in the rat.


Testing the toxicity of effluents to fish.


Glycogen: distribution in the estrus and postpartum hamster uterus.


The treatment of hatching eggs for the control of egg transmitted aspergillosis.


A yeast-leavened, low-protein, low-electrolyte bread.


Mechanical restraints: to use or not to use?


Faster FDA action asked in lawsuit.

Faster FDA action asked in lawsuit.


Pyodermia chronica sinificans?

Pyodermia chronica sinificans?


Integration of research and practice in creating a continuum of care for the elderly.


Assessing functioning of older persons living in the community.


A symposium on the assessment of functions of the aging adult.


Assessment, integration, and environments for older people.


Factor XIII assay by an isotope method. I. Factor XIII (transamidase) in plasma, serum, leucocytes, erythrocytes and platelets and evaluation of screening tests of clot solubility.


Diagnostic assessment of the elderly: a multifunctional model.


Applied research needs in nutrition and aging.


The development of gluconeogenic function in rat liver.


Cats hazardous to your health?

Cats hazardous to your health?


Clinical haemonchosis from maturation of inhibited larvae.


Congenital hemimelia (agenesis) of the radius in a dog and a cat.


Aspergillosis in the frontal sinus of a dog.


Posterior paralysis resulting from malignant lymphoma in a dog.


Medial orbital abscess in a collie dog.

Medial orbital abscess in a collie dog.


Spinal arachnoid calcification: diagnosis.


The determination of zygosity--a study of 608 pairs of twins born in Aberdeen.


'As ever came out'.

'As ever came out'.


Some histopathological, enzyme-histochemical and electron-microscopical data on hypertonic obstructive cardiomyopathy.


Irreversible lung damage in extrinsic allergic alveolitis from pigeon dust inhalation.


Workshop on "The Adolescent in My Practice". Introduction.


Comparison of two sample proportions by the normal difference test. Distribution of chance differences between two sample proportions. Standard error of the difference between two sample proportions. Location of a sample difference on the distribution of chance differences.


Protein-hydrocarbon interactions. Interactions of various proteins with decane in the presence of alcohols. 1. Solutions of proteins were subjected to gentle agitation in the presence of small quantities of decane containing different alcohols. 2. Some of the protein was lost from solution and adsorbed on the surface of the emulsion formed; at the same time some decane was bound to the protein remaining in solution. 3. Comparison of these results with those obtained with pure decane suggests that a mixed film of protein+alcohol is formed on the surface of the emulsion. 4. If the concentration of alcohol in decane is increased the amount of protein adsorbed on the emulsion is decreased. This phenomenon was used to compare the effect of different alcohols in disrupting the hydrophobic interactions between proteins and hydrocarbons.


The effect of oxamate on glycolysis in intact ascites tumor cells. I. Kinetic evidence for a dual glycolytic system.


Mercury poisoning from fish.

Mercury poisoning from fish.


You and the aging in your community.

You and the aging in your community.


Unusual enteritis in Manipal, India.

Unusual enteritis in Manipal, India.


Incidence of Linguatula serrata infection in Cairo mongrel dogs.


Directional flow of fallopian tube secretion in the ewe at onset of the breeding season.


Age-dependent changes in the pituitary-gonadal relationship. IV. Sex difference in rat pituitary FSH content.


The effects of progestagens on cervical mucus.


Ovulation induced by gonadotrophins in the marsupial, Sminthopsis crassicaudata (Gould).


Structure of cyclonerodiol.

Structure of cyclonerodiol.


The factor structure of the Frostig Developmental Test of Visual Perception.


Fracture of the zygomatic bone. Radiologic diagnosis.


Clinical and clinicopathologic findings in tropical canine pancytopenia.


Surgical repair of a ruptured ileocecocolic lymph node in a cat.


Protothecal enterocolitis in a dog.

Protothecal enterocolitis in a dog.


Perforating gastric ulcer associated with lead poisoning in a dog.


A lateral retinacular imbrication technique for the surgical correction of anterior cruciate ligament rupture in the dog.


Polycythemia vera in a cat.

Polycythemia vera in a cat.


Protective effect on infections with Vibrio cholerae in suckling mice caused by the passive immunization with milk of immune mothers.


The role of muscle relaxation in participant modeling.


An experimental analysis of the effectiveness of "shaping" in reducing maladaptive avoidance behavior: an analoguestudy.


Systematic desensitization of snake-avoidance following three types of suggestion.


Hemorrhagic thrombocythemia; control of postsplenectomy thrombocytosis with melphalan.


An experimental study on the reactive changes after disc injuries.


Pressure on the femoral head in osteoarthritis secondary to congenital dislocation of the hip.


The relative radiosensitivity of the nucleus and cytoplasm of Chinese hamster fibroblasts.


Variations in the sensitivity to x-ray-induced mitotic delay during the cell division cycle of the sea urchin egg.


Susceptibility of isotopically labeled mammalian nuclei to deoxyribonuclease I.


X-ray survival of cultured Chinese hamster cells resuming growth after plateau phase.


The dreams of the traumatic neuroses.

The dreams of the traumatic neuroses.


A phenomenon of rebirth: coming alive in analytic and medical patients.


Adolescent group psychotherapy in a hospital setting.


Circular dichroism properties of ethidium bromide-deoxyribonucleic acid complexes.


Effect of rate and number of cell divisions on RNA synthesis.


Short chain intermediate in DNA replication of Ehrlich ascites tumor cells.


RNA polymerase activity of erythroblasts isolated from regenerating or erythroblastosis-infected avian bone marrow.


Factors influencing preputial prolapse in yearling bulls.


Effect of progestins on lactation in the ewe.


Dimethyl sulfoxide as a cryoprotective agent for freezing bovine semen.


Influence of programmed circadian temperature changes on the reproductive performance of rabbits acclimated to two different temperatures.


Internuclear ophthalmoplegia as an early sign of brainstem tumors.


Metabolism of 14C-labeled pyridostigmine in myasthenia gravis. Evidence for multiple metabolites.


Cerebral venous thrombosis in paroxysmal nocturnal hemoglobinuria. Marchiafava-Micheli syndrome.


Diphenylhydantoin intoxication attendant to slow inactivation of isoniazid.


Late-onset proximal myopathy with diabetes mellitus in four sisters.


Lymphocyte stimulation with measles antigen in multiple sclerosis.


Pseudoxanthoma elasticum. Report of an autopsied case with cerebral involvement.


Progression of unilateral tremor and rigidity in Parkinson's disease.


Atrial fibrillation associated with seizure in a case of frontal meningioma.


Immediate postpartum oral contraception. Oral contraceptives were administered on Postpartum Day 5 to 363 patients, 83 of whom were breast-feeding, to determine if bleeding quantity could be reduced and menstrual periods established earlier in the puerperium, to evaluate the effect  on lactation, and to note if side effects could be minimized by initiating pill usage earlier postpartum; 245 patients, of whom 91 were breast-feeding, served as controls.  All of the women were patients at the U.S. Air Force Hospital in Wiesbaden, West Germany.  54% of the lactating mothers on the pill were successfully breast-feeding at 6 weeks compared with 59% of the controls.  87% of the patients taking pills had their 1st menstrual period before 6 weeks postpartum compared with 23% of the controls.  No significant decrease in quantity of bleeding was noted.  Patients taking the pill did report a weight gain.  The uterus returned to normal size sooner in the group taking the pill and there was less breast tenderness.  65% of the multigravida mothers taking the pill thought they had a more favorable postpartum course, 24% saw no difference, and 11% thought their postpartum experience was less favorable.  Patient acceptance was excellent and no major porblems were encountered.


Breech delivery.

Breech delivery.


Factors affecting reports of neonatal deaths in United States and elsewhere.


Pharmacy service in an addiction research center.


The delinquent and the insane: right and adequacy of treatment.


Production of chlorflavonin, an antifungal metabolite of Aspergillus candidus. Production of chlorflavonin, a new antifungal antibiotic, by strains of Aspergillus candidus is described. Two wild strains of the fungus had distinctly different chlorflavonin-producing capabilities. One strain produced 25 mug of chlorflavonin per ml per 4 to 5 days in a pilot scale fermentor with stirring, using a medium containing corn steep liquor and glucose. Production of antibiotic was favored by high rates of agitation-aeration. Crude chlorflavonin was extracted from the whole brew with a hydrocarbon solvent and then purified by recrystallization from benzene and petroleum ether. The overall yield from fermentation brew to pure product was 50%.


Titration of cholera antitoxin in human sera by microhemagglutination with formalinized erythrocytes. Microtiter hemagglutination tests employing formalinized sheep erythrocytes sensitized with either crude or purified cholera toxin were used to assay the cholera antitoxin content of human sera. Comparable results were obtained with either crude or purified toxin-sensitized cells with the exception of two sera that gave unusually high hemagglutination titers with the crude toxin. Sera from 13 convalescent cholera patients showed a high degree of correlation between antitoxin levels as determined in vitro by the hemagglutination test and in vivo by the skin permeability factor neutralization test. Fourfold or greater rises in antitoxin levels between acute and convalescent sera were detected in 9 of 15 patients with bacteriologically proven cholera. No significant increases in titer were observed in 14 cases of noncholera diarrhea. Cholera antitoxin was detected by hemagglutination in only 1 of 33 sera, obtained from eight countries, containing vibriocidal antibodies. Formalinized sheep erythrocytes sensitized with toxin and stored at 4 C in the presence of 1:10,000 thimerosal were stable and sensitive for at least 6 months (the longest time tested).


Gamma-irradiated Venezuelan equine encephalitis vaccines. The efficacy of Formalin-inactivated Venezuelan equine encephalitis (VEE) vaccine has been reported to be low for man. Although a live VEE vaccine has been shown to be highly effective for the protection of laboratory workers, local and systemic reactions have occurred in approximately 20% of inoculated individuals. Therefore, studies were initiated in an attempt to produce an inactivated vaccine of high potency with low toxicity. Inactivated VEE vaccines were prepared by exposing virus suspensions to 8 x 10(6) or 10 x 10(6) r of gamma radiation. Irradiated VEE vaccines prepared from virus suspensions produced in Maitland-type chick embryo (MTCE) cell cultures and in monolayer cultures of human diploid strain WI-38 cells were highly immunogenic for mice and guinea pigs. Guinea pigs vaccinated with a series of three inoculations of vaccine (MTCE) survived challenge with at least 10(8.4) mouse intracerebral 50% lethal doses of VEE virus. Irradiated vaccines induced high levels of serum-neutralizing and hemagglutinin-inhibiting antibodies in guinea pigs and rabbits. These findings suggest that ionizing radiation may be effective in the preparation of an inactivated VEE vaccine.


Salmonella contamination in a poultry-processing plant. Bacteriological examination of 1,427 samples from a poultry-processing plant over a 2-year period yielded 202 (14.2%) cultures positive for salmonellae. The results indicate that contamination is reduced by washing procedures within the plant but that recontamination of the carcasses occurred in at least two different stages of processing, i.e., during evisceration and chilling. There was evidence of spread of salmonellae from flock to flock during the serial processing of flocks, but the spread was usually not extensive. The serotypes of salmonellae isolated in this study were similar to those of chicken origin reported from other areas of the country.


Method for extracting viral hemagglutination-inhibiting antibodies from the nonspecific inhibitors of serum. Various methods are used to remove nonspecific inhibitors from sera before titering viral hemagglutination-inhibiting antibodies. These methods have several undesirable features; some are tedious and time-consuming, some remove antibody along with nonspecific inhibitors, and different techniques are usually required to remove the nonspecific inhibitors for different viruses. This communication describes a single method that uses diethylaminoethyl-Sephadex to extract the immunoglobulin G antibodies for several viruses from nonspecific inhibitors. The procedure is fast, simple to perform, and removed the nonspecific inhibitors for influenza, Western equine encephalitis, dengue-2, and rubella viruses.


Somatic antigens of Streptococcus group E. I. Comparison of extraction techniques. Eleven Streptococcus group E strains, representing serotypes I, II, III, IV, V, and "untypable" isolates, were extracted by formamide, trichloroacetic acid, and hydrochloric acid under various conditions in an effort to determine the best method for recovering maximum amounts of group and type antigens. The group antigen was found to be relatively stable, and adequate amounts for identification purposes were recovered by a wide spectrum of conditions. Type-specific antigens were relatively labile, and were destroyed at low pH in acid hydrolysis or by prolonged heating in formamide hydrolysis. The best single procedure for recovering both type and group antigens from Streptococcus group E was formamide hydrolysis for 30 min at 180 C.


Somatic antigens of Streptococcus group E. II. Separation and a partial physicochemical characterization. Antigenic extracts of Streptococcus group E (SGE) were subjected to fractional ethanol precipitation, block (preparative) electrophoresis, and gel filtration for the purpose of separating the type antigen from the group antigen. Ethanol precipitation was ineffective in separating the substances. Block electrophoresis yielded serologically pure group antigen and a mixture of type and group antigen. Serologically pure type antigen was obtained by gel filtration. In some cases, pure group antigen was also recovered; in others, it was contaminated with type antigen. Gel filtration column effluents of antigenic extracts of SGE serotypes, I, II, III, IV, V and "untypable" isolates, collected from the region in which type antigen was eluted, were studied by paper chromatography and infrared spectrophotometry in an effort to develop a nonserological means of detecting type antigen. Hydrolysates of type antigens or suspect type antigens of serotypes I through V contained l-rhamnose, d-glucose, and several unidentified substances. d-Galactose also was present in hydrolysates of serotypes III and V. Untypable isolates and negative controls contained traces of d-glucose only. The data suggested that serotypes I through V contained a type antigen and that the untypable isolates were devoid of type antigen. Infrared absorbance spectra seemed to support the paper chromatography data.


Application of agglutinins for the rapid and accurate identification of medically important Candida species. Agglutinins have been prepared against the medically important Candida species. Crude antisera to the various species demonstrated intense cross-reactions with heterologous yeastlike fungi as well as with many true yeasts. However, carefully monitored adsorptions of selected antisera allowed the production of six factor sera that proved useful in a slide agglutination test. These six sera permitted the rapid and specific identification of C. guilliermondii, C. krusei, C. parapsilosis, and C. pseudotropicalis. They also allowed the delineation of two groups: (i) C. albicans (type A)-C. tropicalis and (ii) C. albicans (type B)-C. stellatoidea. C. albicans type A could be readily distinguished from C. tropicalis by its ability to form germ tubes in serum. C. stellatoidea could be distinguished from C. albicans type B by its predominantly filamentous growth on a nutritionally deficient medium. The medically important Candida species could be identified within 24 hr by the combined use of serological and morphological procedures.


Fungal disfigurement of paper, and soft rot of cedar shingles. Disfiguration of paper by Cladosporium cladosporioides is described, and the association between "soft rot" fungi and the greying of cedar shingles in marine locations is reported.


Q fever in the Milwaukee area. I. Q fever in Milwaukee area cattle.


Q fever in the Milwaukee area. 3. Epidemiological studies of Q fever in humans.


Studies on the absorption, distribution, and elimination of amiquinsin hydrochloride, a hypotensive drug.


Optical diffusion in blood.

Optical diffusion in blood.


Comments on canine brucellosis due to Brucella canis.


Comments on epizootiology and control of canine brucellosis.


Newer knowledge on the use of measles vaccine for canine distemper prophylaxis.


Prevention of canine distemper on infected premises.


Early immunization against canine distemper and hepatitis, using combined vaccines.


Comments on the use of measles virus for distemper prophylaxis.


Comments on methods for assaying canine biologics.


Use of cell cultures in vaccine production: primary cell cultures.


Comments on use of rabies vaccines.

Comments on use of rabies vaccines.


Time of neuron origin in the diencephalon of the mouse. An autoradiographic study.


Sexuality in male epileptics.

Sexuality in male epileptics.


Puerperal investigation of women with asymptomatic bacilluria.


Relationship between thymus-dependent cells and humoral immunity.


Postmortem leukocyte culture studies in sudden infant death.


Analysis of the code relating sequence to secondary structure in proteins.


Circular dichroism study of the f2a1 histone in the presence of polyvinylphosphate and DNA.


Amphetamine induced increase in tyrosine hydroxylase activity.


Irreversible coma associated with electrocerebral silence.


A simple constant-infusion manometric test for measurement of CSF absorption. I. Rationale and method.


Pupil size and spontaneous pupillary waves associated  with alertness, drowsiness, and sleep.


Episodic blindness as a late effect of head trauma. Electrophysiological study of 3 cases.


In vitro incubation of brain hemispheres. Fluid spaces and amino acid uptake.


Prognostic criteria for cerebrospinal fluid shunting from isotope cisternography in communicating hydrocephalus.


Blood flow to white matter during maturation of the brain.


The frequency of diabetes mellitus in families of patients with multiple sclerosis.


Synthesis of proteins in cells infected with herpesvirus. IV. Analysis of the proteins in viral particles isolated from the cytoplasm and the nucleus.


Purification and properties of Semliki Forest virus nucleocapsids.


The effect of polyvinylsulfate on the ribonucleoprotein of influenza virus.


Perforation of small and large intestine following exchange transfusion.


Comments on: "systematic desensitization: expectancy change or counterconditioning?


The role of visual imagery in desensitization.


An experimental investigation of the implosion technique.


Cognitive desensitization as a model of systematic desensitization.


Effects of systematic desensitization, programmed fantasy and bibliotherapy on a specific fear.


A standardized desensitization program applicable to group and individual treatments.


Control of aversive stimulus termination in systematic desensitization.


The comparative effectiveness of pairing aversive imagery with relaxation, neutral tasks and muscular tension in reducing snake phobia.


Recent research on yellow fever in Kenya.


Phagocytosis of latex beads by isolated thyroid cells.


Autoradiographic methods in enzyme cytochemistry. IV. The cellular and ultrastructural localisation of organophosphate-sensitive esterases in mouse liver and kidney.


The locomotion of fibroblasts in culture. II. "RRuffling".


Dry mass determination by interference microscopy; agreement with quantitative electron microscopy.


Nondisjunction of chromosomes in a synchronized cell population initiated by reversal of Colcemid inhibition.


Quantitation of lysosomal enzyme changes during enforced mammary gland involution.


A serum macromolecule-supplemented medium for frog cell lines.


Differential ordering of stimulus presentation in systematic desensitization.


The clinical importance of brucellosis in veterinary surgeons in private practice.


Teleost urophysis. II. Biological characterization of the bladder-contracting activity.


Pharmacologic approach to contraception. Current information on oral contraceptives is presented for the use of pharmacists.  The normal ovarian and uterine cycles and the effect of the combination and sequential oral contraceptives on ovulation are described.  Information is given on product formulation and effectiveness, and how to minimize side effects by careful selection of regimen and dosage.  Side effects, from milk to severe, are listed with suggestions on how to alleviate them by change of regime, or in some cases, discontinuance of therapy.  Side effects of unknown significance such as alteration of blood proteins, blood lipids, carbohydrate metabolism and cellular changes of the uterus may occur.  Patient conditions which are contraindicative to oral contraceptive use are listed.  Promising developments for future use are depot therapy, continuous low dosage progestin therapy, and postcoital estrogen therapy.  In this new era of pharmacologic contraception, it is likely that a woman will continue to continue to consult her pharmacist regularly.


An analysis of the development of conjunctival papillae and scleral ossicles in the eye of the scaleless mutant.


Oogenesis in the suppressor of hairy-wing mutant of Drosophila melanogaster. II. Nucleolar morphology and in vitro studies of RNA protein synthesis.


Mycotoxins.

Mycotoxins.


Heart and aortic arch anomalies: anomalous right subclavian artery, complete interruption of the aortic arch, and associated anomalies of the heart.


Colonic stenosis in the newborn: the possible thromboembolic etiology of intestinal stenosis and atresia.


Pharmacokinetic evidence for saturable renal tubular reabsorption of riboflavin.


Distribution, excretion, and metabolism of 14C-labeled quaternary ammonium salt of mepazine and promethazine in rats.


Some data on twinning in Singapore.

Some data on twinning in Singapore.


Renal development in dysplasia of the fetal pituitary.


Bile acid concentrations in serum during infancy and childhood.


Changes of hypoglossal nerve activity during inhibition of chewing and swallowing by lingual nerve stimulation.


Increase of sodium concentration near the inner surface of the nodal membrane.


Liver panangiography in the assessment of portal hypertension in liver cirrhosis.


Electrical and mechanical responses from ventricular muscle fibers after inactivation of the sodium carrying system.


The development of hearing in man: an assessment of current status.


Modification of arginine in proteins by oligomers of 2,3-butanedione.


Studies on the substrates of D-fructose 1,6-diphosphate aldolase in solution.


Spore germination in Dictyostelium discoideum: trehalase and the requirement for protein synthesis.


The mitochondrial and ribosomal DNA components of oocytes of Urechis caupo.


Regulation of ribosomal RNA synthesis and its bearing on the bobbed phenotype in Drosophila melanogaster.


Control of epithelial development in normal and pathological connective tissue from oral mucosa.


Anorexia nervosa, secondary aldosteronism and angiopathy.


Developement of the adrenergic innervation and chromaffin cells in the human fetal gut.


Effect of intrauterine contraceptive suture on the response of rat uterus to prolonged estrogen treatment.


Fluorine toxicosis and industry.

Fluorine toxicosis and industry.


Nature and site of action of 3-chloro-1,2-propanediol--an oral antifertility agent for the male.


Alkaline phosphatase activity in the stratified epithelia of penis and cervix in normalcy and malignancy.


Drug abuse programs--timely efforts.

Drug abuse programs--timely efforts.


Solanaceous alkaloids and 5-hydroxytryptamine metabolism.


Amino acid transport by the filamentous fungus Arthrobotrys conoides. Uptake of l-valine by germinated spores of Arthrobotrys conoides has all the characteristics of a system of transport that requires an expenditure of energy by the cells. It is dependent on temperature and has an energy of activation of 16,000 cal/mole. Uptake is optimal at pH 5 to 6. l-Valine accumulated against a concentration gradient and is not lost from the cells by leakage or exchange. The process requires energy supplied by the metabolic reactions that are inhibited by catalytic amounts of 2,4-dinitrophenol and azide. The kinetics of the system are consistent with a mechanism of transport that depends on a limited number of sites on the cell surface, and the Michaelis constant for the system is 1.5 x 10(-5) to 7.5 x 10(-5)m. Modification of the amino or carboxyl group abolishes l-valine uptake. The process is competitively inhibited by d-valine, glycine, and other neutral amino acids (K(i) = 1.5 x 10(-5) to 4.0 x 10(-5)m), indicating a lack of stereospecificity, and also indicating that aliphatic side chain is not required for binding with the carrier. The transport system has less affinity for acidic amino acids (glutamic and aspartic acids) than neutral amino acids, and a greater affinity for basic amino acids (histidine, lysine, and arginine). The range of affinity is in the order of 100, as measured in terms of K(i) values for various compounds. The data presented provide suggestive evidence that the uptake by A. conoides of all amino acids except proline is mediated by a single carrier system that possesses an overall negative charge.


Propagation and growth cycle of Rickettsia quintana in a new liquid medium. The growth cycle of Rickettsia quintana was studied for the first time in liquid culture. Growth of the microorganism in a transparent broth medium was made possible by the finding that fetal calf serum (FCS), but not calf serum (CS), satisfied the requirement of R. quintana (Fuller strain) for red blood cell lysate. The three constituents of the medium, other than FCS, were autoclavable. The growth cycle was characterized by a lag phase of approximately 24 hr, an exponential growth phase of 72 hr, and a doubling time of approximately 4.5 hr. In FCS medium, titers increased 10(5)-fold over starting titers and reached a peak after 5 days of greater than 10(8) colony-forming-units (CFU)/ml. Optical density readings at 520 nm (OD(520)) served as useful estimates of the titers only during the last 30 hr of exponential growth. Before this time, titers were below 3 x 10(7) CFU/ml and could not be detected at OD(520). The growth-promoting activity of FCS appeared to be a normal serum component widely distributed among fetal calves. FCS from five commercial suppliers supported growth of R. quintana. The active factor(s) was: (i) non-dialyzable, (ii) resistant to heating at 56 C for 30 min, and (iii) partially inactivated at 100 C in 2 min and completely lost at 100 C in 10 min. The results emphasize the presence of erythrocyte and serum factors other than hemoglobin which stimulate the growth of R. quintana.


Crisis intervention in industry.

Crisis intervention in industry.


Lipofuscin pigment accumulation in spontaneous mammary carcinoma of A/Jax mouse.


Metabolism of valine by the filamentous fungus Arthrobotrys conoides. Uptake of valine by Arthrobotrys conoides was an active process and was independent of its incorporation into cellular protein. Chemical fractionation of cells supplied with (14)C-l-valine for different time intervals revealed that the amino acid initially entered a pool of metabolic intermediates and was extractable with cold trichloroacetic acid. After a 4-min interval, some intracellular valine was incorporated into cell proteins, but most underwent metabolic transformation to a variety of products that included carboxylic acids and other amino acids. Carbon derived from valine was not localized in the lipid or nucleic acid fraction of cells, but some was completely oxidized and recovered as metabolic (14)CO(2). Autoradiograms of paper and thin-layer chromatograms of acid hydrolysates of cellular protein identified the following amino acids as having originated from valine: glutamate, aspartate, alanine, and leucine. Similar analysis of cold trichloroacetic acid extracts established that (14)C supplied as l-valine had been transformed also to alpha-ketoisovalerate, isobutyrate, propionate, succinate, malate, oxalacetate, pyruvate, and alpha-ketoglutarate. Pathways for transformation of the carbon skeleton of valine to various metabolic products are proposed.


Meeting the challenge of changing needs.


Cephalosporium meningitis.

Cephalosporium meningitis.


The effects of tentoxin on chlorophyll synthesis and plastid structure in cucumber and cabbage. To determine if chlorosis caused by tentoxin, a toxin produced by Alternaria tenuis Nees., is due to interference with chlorophyll synthesis directly or to disruption of normal chloroplast development, the effects of the toxin on these processes in cucumber (Cucumis sativus L.) and cabbage (Brassica oleracea L., var. capitata) were studied. Cucumber cotyledons are highly sensitive to the toxin but exhibited no interference with the conversion of protochlorophyll(ide) to chlorophyll(ide) or with the general time course pattern of chlorophyll synthesis, although there was a 90% reduction in chlorophyll concentration. In cabbage, which shows no chlorosis in the presence of the toxin, there was a slight stimulation of chlorophyll synthesis in the presence of the toxin. Electron microscopy revealed that in cucumber, toxin treatment interferes with development of prolamellar bodies and lamellae, and results in deformed plastids. No such effects were noted in toxin-treated cabbage tissues. Plastids in toxin-treated cotyledons of both cucumber and cabbage contained more starch than plastids in nontreated tissues. It was concluded that tentoxin acts through disruption of normal plastid development, rather than through direct interference with chlorophyll synthesis.


Absence of avarian compensatory hypertrophy after unilateral ovariectomy during the anestrous season in the ewe.


Effect of preputialectomy on fighting behavior in mice.


Bacteriology of postpartum oviducts and endometrium. The risk of infection from puerperal tubal ligation is studied 1, 2, 3, and 5 days postpartum.  Aliquots of 52 oviduct homogenates and 26 endometrial saline aspirates were cultured in serum.  PPLO, tryptic soy, and thioglycolate broth, and blood, PPLO, and chocolate agar.  A Brown and Brenn Gram stain was run on oviduct sections.  Results indicated that, except for contamination with airborne Staphylococcus epidermidis, 1 oviduct harbored S. epidermidis, and 1 endometrium yielded Streptococcus epidermidis and Staphylococcus epidermidis.  Fever occurred only in 2 other patients whose cultures were sterile; one had bronchial pneumonia and the other had positive transcervical lochial culture.  No histologies were positive, and no fastidious organisms, L-forms, or fungi were cultured.  The widely held view that tubal sterilization is unwise 48 hours after delivery because of infection is therefore opposed.


Slide rule for management of erythroblastosis fetalis.


Ocular changes in granulomatous ileocolitis.


The mechanism of prism formation in teeth: a hypothesis.


Anthrax. Biological and immunological principles of diagnosis and prevention. 3. Biological, biochemical and immunological study of anthraxin.


New combined alum hydroxide adsorbed diphtheria-tetanus-pertussis-vaccine with parapertussis component. I. Reactogenicity and serological efficacy.


Staphylococcal bacteraemia with a fulminant course. Comparative study in vitro and in vivo.


Precipitin reaction between mucopeptide of group A streptococci and human sera (preliminary communication).


Participation of nonspecific factors in the destruction of type M12 streptococci in vitro. II. Indispensability of human complement and role of other factors in the bactericidal test.


Salmonella surveillance in Czechoslovakia. Incidence of salmonella serotypes in man in the years 1966-1967.


On the immunological reactivity of penicillin, cephalosporin and tetracycline antibiotics.


Study on the Au-SH-antigen.

Study on the Au-SH-antigen.


Q fever investigation in Slovakia. I. Isolation of the agent from ticks and serological surveys in small mammals in the districts of Zvolen and Lucenec, Central Slovakia Region.


Biological effect of low concentrations of furfurol under experimental conditions.


Anterior chamber angle recess.

Anterior chamber angle recess.


Some observations on urinary diversion.

Some observations on urinary diversion.


Management of carpal injuries in the fast-gaited horse.


Haemolytic disease of the newborn in calves.


Reference collection of strains of avian infectious bronchitis virus.


Factors affecting survival in the transportation of sheep by sea in the tropics and subtropics.


Ribonuclease-sensitive infectivity of chikungunya virus from BHK21 cells infected with the virus.


Acetamido group in the binding and catalysis of synthetic substances by lysozyme.


Induction of glutamine synthetase in embryonic neural retina in vitro by inhibitors of macromolecular synthesis.


Pancreatic dose-response curves to intravenous secretin in man.


On the occurrence of Calicophoron cauliorchis (Stiles and Goldberger, 1910) Nasmark, 1937 paramphistomidae: trematoda) in sheep in India.


The histochemical demonstration of phosphoglucose isomerase.


Treatment of theileriasis in cross bred and pure bred exotic breeds of cattle.


Pulmonary abscess (Malli) in a camel.

Pulmonary abscess (Malli) in a camel.


A case of pressure syndrome due to Cysticercus cellulosae in the brain of a dog.


Clinical trials of iron arsenite and strychnine in vocal cords paralysis in dogs.


Treatment of insecticide poisoning in calf with atropine sulphate.


An evaluation of public health hazards of barbecued chickens.