The experimental production of zinc deficiency in the rat.


Tumours of the retinal pigment epithelium.


Post-radiation retinopathy. A fluorescence fundus angiographic study.


Ocular signs in chronic renal failure.

Ocular signs in chronic renal failure.


Ocular leprosy in Uganda.

Ocular leprosy in Uganda.


Lens displacement associated with pseudocapsular exfoliation. A report on 19 cases in the Southern Bantu.


Ocular thermography.

Ocular thermography.


Treatment of congenital and juvenile cataract with intraocular lens implants (pseudophakoi).


Dysplasia epiphysialis punctata with ocular anomalies.


Interpretation of brain scans by computer analysis.


A pulmonary disease in patients ventilated with high oxygen concentrations.


Follow-up thyroid carcinoma by whole-body counting.


A dual detector system for thyroid uptake measurement.


Red cell production in the continuously irradiated mouse.


The Spigelian hernia: radiographic manifestations.


A device to facilitate blood background subtraction in renograms.


Hazard control for helium-neon gas lasers.


Improvements in intravenous cholangiography.


A simple method of making the "isodose shift" obliquity correction.


Model analysis of impression tonometry and tonography.


Responses of iris blood flow to stimulation of the cervical sympathetic in the rabbit.


Effect of changes in external ion concentrations and 2,4-dinitrophenol on the conductance of toad lens membranes.


Ultrastructure of lymphatic vessels in the vascularized rabbit cornea.


Flow conductivity of human corneal stroma.


Human tear film lipids. I. Composition of the principal non-polar component.


Flow of water in the sclera.

Flow of water in the sclera.


Nature and distribution of two distinct forms of hexokinase within the mammalian lens.


Quantitative aspects of glucose catabolism by rainbow and lake trout ocular tissues including alterations resulting from various pathological conditions.


Intraocular fluid dynamics. II. Postmortem changes in solute concentrations.


Use of embryonic chick lens for screening potentially toxic chemicals.


Effect of topical application of hydrocortisone on the corneal thickness.


Efflux of 22Na and 86Rb from the crystalline lens.


Soluble lens proteins in rats on different sugar diets.


Identification of tuoromycin with beta-rubromycin.


The effect of long-term lymphatic drainage on the lympho-myeloid system in the guinea-pig.


The systemic distribution of soluble antigen injected into the footpad of the laboratory rat.


A potent new oral antidiabetic drug--glibenclamide.


Enhanced vascular permeability induced in mice by larch arabinogalactan.


Disseminated intravascular coagulation (a clinicopathological study of 16 cases).


A fatal transfusion reaction due to anti-Duffy (Fya). Case report.


Anti-Fyb (Duffy) as a cause of transfusion reaction. Case report.


Sterility testing: detection of yeast and fungal contamination.


Umbilical cyst of vitello-intestinal duct origin associated with Meckel's diverticulum in a child.


Some observations on the secretion of blood group substances in the saliva in health.


Osteosclerosis in multiple myeloma. A case report.


Hemolytic anemia. II. Thalassemia syndromes and hemoglobinopathies.


The possible role of autoimmunity in etiopathogenesis of infantile cirrhosis of liver.


Autoimmune hemolytic anemia in infancy and childhood.


Hypogammaglobulinemia in a child.

Hypogammaglobulinemia in a child.


Some developmental aspects in relation to immunity and allergy.


In vitro correlates of delayed hypersensitivity in tuberculosis.


Ultrastructure of "tubular body" in the endothelial cells of the ocular blood vessels.


Experimental myopia in rabbits.

Experimental myopia in rabbits.


Corticosteroid provocative testing.

Corticosteroid provocative testing.


Proline transport by rabbit ciliary body-iris in vitro.


Effects of hydroxypropyl methylcellulose and polyvinyl alcohol on intraocular penetration of topical fluorescein in man.


The influence of binding domains on the nature of subunit interactions in oligomeric proteins. Application to unusual kinetic and binding patterns.


Bacterial degradation of biotin. V. Metabolism of 14C-carbonyl-labeled biotin d-sulfoxide.


The tryptophan microenvironments in apomyoglobin.


Hormonal regulation of hyaluronidase during spermatogenesis in the rat.


Analysis of Hill interaction coefficients and the invalidity of the Kwon and Brown equation.


Rat liver adenosine triphosphate: adenosine monophosphate phosphotransferase activity. I. Purification and physical and kinetic characterization of adenylate kinase 3.


Rat liver adenosine triphosphate: adenosine monophosphate phosphotransferase activity. II. Subcellular localization of adenylate kinase isozymes.


Isolation and characterization of plasma membranes from human blood platelets.


Genetic differences in the extent of aryl hydrocarbon hydroxylase induction in mouse fetal cell cultures.


Localization of the active site through chemical modification of the encephalitogenic protein.


Carboxamidomethylation and inactivation of rabbit muscle phosphoglucose isomerase.


Studies on the enzymatic conversion of 5 alpha-cholesta-8, 14-dien-3 beta-ol to cholesterol.


Acetyl coenzyme A carboxylase. The effects of biotin deficiency on enzyme in rat liver and adipose tissue.


Transcarboxylase. IX. Parameters effecting dissociation and reassociation of the enzyme.


Rare earth metal ions as probes of calcium ion binding sites in proteins. Neodymium(3) acceleration of the activation of trypsinogen.


Transcarboxylase. X. Assembly of active transcarboxylase from its inactive subunits and incorporation of the biotin-carboxyl carrier protein.


Phage typing of the typhoid bacillus.

Phage typing of the typhoid bacillus.


Phage typing of Salmonella typhi and S. paratyphi A related to salmonellosis in Egypt.


Evaluation of chloramphenicol given orally and ampicillin given either intramuscularly or orally in the treatment of Salmonella enteric fever.


Antimicrobial therapy of salmonella infections.


Immunological control of typhoid fever.

Immunological control of typhoid fever.


Pathogenesis of typhoid fever.

Pathogenesis of typhoid fever.


Antibiotic resistance factors.

Antibiotic resistance factors.


Typhoid fever as an endemic disease of importance in the Middle East.


Surgical complicatons of typhoid.

Surgical complicatons of typhoid.


Use of indigenous pacemaker in the treatment of complete heart block.


Niridazole in amoebic dysentery.

Niridazole in amoebic dysentery.


Blood pressure variations in aging. A study in a Central Indian population.


A comparative trial of furazolidone and chloramphenicol in typhoid fever.


The penultimate in the diagnosis of cancer.


Osteogenesis imperfecta.

Osteogenesis imperfecta.


Human histocompatibility antigens.

Human histocompatibility antigens.


The hippuran 131-iodine renal scan in renal failure.


Leiomyoma and leiomyosardcoma of the rectum.


Man and the wart.

Man and the wart.


Advances and future problems in surgery.


Ectopic rhythms due to bradycardia in myocardial infarction.


Carbenicillin.

Carbenicillin.


The early phase of endocytosis in rat thyroid follicle cells.


Ultrastructural study of experimental globoid cells.


Effects of ethanol on the biogenesis of mitochondrial membranes and associated mitochondrial functions.


Autoradiographic studies on cell population kinetics in dog gastric and rectal mucosa. A comparison between in vitro and in vivo methods.


Continuous measurement of blood gases in vivo by mass spectrography.


A percutaneous electrode for long-term monitoring of bio-electrical signals in humans.


Recording of respiration by electrical impedance change from the dogfish in sea water.


Manganese dioxide depolarizer for biomedical electrodes.


The relationship between vessel-wall elasticity and Korotkoff-sound frequency.


Modifications to a miniature pressure transducer for the measurement of intracranial pressure.


Linear valves for small flows.

Linear valves for small flows.


On the origin of scatter in results of human bone strength tests.


A wide-range linear beat-by-beat cardiotachometer.


The correlation operator and pulse trains.


The Rochester Ultimate Weapon. A high speed real-time interpretive computer language for biologists.


Constant current stimulation through a microelectrode.


A versatile amplitude analyzer for EEG signals to provide feedback stimuli to the subject.


A temperature monitor and proportional direct current controller.


A catheter inserted device for the creation of reversible aortic insufficiency.


Image quality in the human eye.

Image quality in the human eye.


Calibration of ultrasonic beams for bio-medical applications.


Tremor recording in Parkinson's disease.


The effects of small doses of ionizing radiation.


Oxygen cathode measurements in the mouse testis.


Estimation of the standard error of retention in whole-body counter studies and its relevance to counter design.


Threshold detection tests in radioisotope scanning.


The consistency of FeSO4 dosimetry.

The consistency of FeSO4 dosimetry.


The effect of spectrophotometry error on the accuracy of the perspex H.X. megarad dosemeter.


The response of thermoluminescent dosimetric lithium borates equivalent to air, water and soft tissue and of LiF TLD-100 to low energy x-rays.


The energy response of LiF, CaF2, and Li2B4O7: Mn to high energy radiations.


A method of exponential separation applicable to small computers.


Improvements of solid state x-ray image intensifiers.


Phytochemical investigation of the flowers of Thalictrum rugosum.


Seasonal variations in sapogenin yields from Dioscorea sylvatica and D. hondurensis.


Alkaloids of Coptis groenlandica.

Alkaloids of Coptis groenlandica.


Pentacyclic triterpenoids from Euclea kellau.


Colorimetric determination of tomatine in tomato plants.


Intra- and interspecific differentiation within the Achillea genus.


Chemical examination of the leaves of Murraya koenigii.


Investigation of Erythrina SPP. IV. Study of the chemical constituents of seeds of Erythrina variegata var. orientalis.


The steroid sapogenin constituents of Agave americana, A. variegata and Yucca gloriosa.


Another method of bringing the midface forward.


Secondary rhinoplasty.

Secondary rhinoplasty.


Use of the extensor pollicis brevis to restore abduction in the unstable thumb.


Operative treatment of fractures of the mandibular condyle in children. Using the post-auricular approach.


Concave-convex arthrodeses in joints of the hand.


I'm against a rigid core curriculum prior to specialty training in plastic surgery.


Correction of hypertrophied earlobes in leprosy.


Esthetic surgery and the plastic surgeon.


Open-sky approach for reduction of naso-orbital fractures. Case report.


Reconstruction of partial loss of the auricle.


Pectus excavatum: use of preformed prosthesis for correction in the adult. Case report.


A new technique of chin augmentation.

A new technique of chin augmentation.


Current views on schizophrenia.

Current views on schizophrenia.


Day hospitals.

Day hospitals.


Behaviour therapy.

Behaviour therapy.


The autistic child.

The autistic child.


Family psychiatry and family practice.

Family psychiatry and family practice.


The present status of psychotropic drugs.


The use of ultrasonics in physical medicine.


Falling as a cause of admission to a geriatric unit.


'Idiopathic epilepsy'.

'Idiopathic epilepsy'.


Cardiac complications of coxsackie virus group B infection.


The value of vaccination against influenza.


An influenza vaccination programme for hospital staff winter 1968-1969.


Group practice in a modern office block.


Thoughts at random. A running commentary.


Use of amantadine in an epidemic of 'Hong Kong' influenza type A2 in family practice.


Problems of child health in West Cameroon.


Influenza in general practice.

Influenza in general practice.


Modern views on physiology. XXI. Regulation of reproduction.


Steroid excretion in molar pregnancy and early hormone-induced pregnancy.


Oestriol in amniotic fluid.

Oestriol in amniotic fluid.


Progesterone metabolism in pregnancy.

Progesterone metabolism in pregnancy.


Hormone excretion in hormone-induced pregnancy.


Assessing the demographic effect of a family planning programme.


Factors influencing prosthetic procedures.


Oestrogen and pregnanediol excretion in various obstetrical populations.


Heterotopic bone formation in a synthetic sponge.


Problems in the treatment of femoral neck fractures.


Assessment of biological properties of implants before their clinical use.


A new method of treatment of pertrochanteric fractures.


The significance of good reduction in medial fractures of the femoral neck.


Some factors influencing the duration of morbidity in industry. Introduction.


Sickness absenteeism from the point of view of an industrial Medical Officer.


Some factors influencing the duration of morbidity in industry.


Motivational factors affecting absence and duration of absence from work.


Some factors influencing the duration of morbidity in industry. National and international trends.


Some factors influencing the duration of morbidity in industry. The employer's point of view.


The rehabilitation of patients with neurological disorders.


Neurosurgical patients and medical rehabilitation.


Rehabilitation.

Rehabilitation.


The rehabilitation of elderly patients.

The rehabilitation of elderly patients.


Rehabilitation in orthopaedics.

Rehabilitation in orthopaedics.


Medical rehabilitation.

Medical rehabilitation.


Treatment of cerebral palsy in the severely subnormal.


Rehabilitation in the services. 3. The Royal Air Force.


Social problems.

Social problems.


Industrial rehabilitation.

Industrial rehabilitation.


Voluntary organizations.

Voluntary organizations.


Jejuno-ileal atresia.

Jejuno-ileal atresia.


Diverticular disease of the colon.

Diverticular disease of the colon.


The management of some aspects of lower venous disorders.


Spleno-renal shunt constructed below the body of the pancreas.


Post-prostatectomy urinary incontinence.


Steroids, antibiotics, sulphonamides and the anaesthetist.


Secondary lymphoedema.

Secondary lymphoedema.


Intrasplenic haematoma.

Intrasplenic haematoma.


Measurement of inferior esophageal sphincter pressure: a comparison of open-tip, balloon and infusion techniques.


Furrier's lung.

Furrier's lung.


Management of coarctation of the aorta in the first six weeks of life.


Tracheo-oesophageal fistula and oesophageal atresia: results of 30 years' experience.


Changes in airways conductance on smoking a cigarette. A study of repeatability and of the effect of particulate and vapour phase filters.


Design and construction of fascia lata aortic valve prostheses.


Central flow tilting disc valve for aortic valve replacement.


Pulmonary function during pregnancy in normal women and in patients with cardiopulmonary disease.


Respiratory impairment and airway closure in patients with untreated idiopathic scoliosis.


The value of simple tests for peristaltic activity in hiatus hernia.


Acquired pulmonary stenosis.

Acquired pulmonary stenosis.


Response of the gullet to gastric reflux in patients with hiatus hernia and oesophagitis.


The use of ancrod to prevent thrombosis on prosthetic heart valves. An experimental study.


Gross hypertrophic pulmonary osteoarthropathy in a 7-year-old child.


Congenital cleft sternum.

Congenital cleft sternum.


Fibrosing alveolitis and polymyositis.

Fibrosing alveolitis and polymyositis.


Agriculture--has it any future?

Agriculture--has it any future?


The exposure of day-old chicks to infectious bronchitis and the subsequent development of the oviduct.


The role of mycoplasma WRI as a primary pathogen of poultry.


Contagious bovine pleuropneumonia: artificial reproduction.


Streptomyces mediolani (Arcamone et al.) emend. Bianchi et al. and its production of carotenoids.


Anaerobic formation of n-decyl alcohol from n-decene-1 by resting cells of Candida rugosa.


Interpretation of serial sections.

Interpretation of serial sections.


A contribution of probability calculus to the interpretation of the fine structure of bacterial chromosomes and comparable objects.


Electron microscopic histochemistry of lysosomes in neurosecretory nerve endings and pituicytes of rat posterior pituitary.


The hagfish retina: fine structure of retinal cells in Myxine glutinosa, L., with special reference to receptor and epithelial cells.


The alkylation of DNA in vitro by isopropyl methanesulfonate.


Matrix-bound enzymes. I. The use of different acrylic copolymers as matrices.


Pseudomonas cytochrome c peroxidase. I. Purification procedure.


Bacterial carotenoids. 31. C50-carotenoids 5. Carotenoids of Halobacterium salinarium, especially bacterioruberin.


Bacterial carotenoids. 32. C50-carotenoids 6. Carotenoids from Corynebacterium poinsettiae including four new C50-diols.


The molecular and crystal structure of dehydroascorbic acid.


A convenient synthesis of 2,3,6-tri-0-methyl-D-galactose.


Bacterial carotenoids. 35. Total synthesis of 1,2-dihydro- and 1,2,1',2'-tetrahydrolycopene.


Pseudomonas cytochrome c peroxidase. II. Localization of cytochrome c peroxidase in Pseudomonas fluorescens.


Identification and determination of methylmercury compounds in fish using combination gas chromatograph-mass spectrometer.


Utilization of malonyl-CoA for the biosynthesis of beta-carotene and ergosterol in cell-free preparations from Blakeslea trispora.


Rate of acetylation of alpha-chymotrypsin by p-nitrophenyl [1-14C] acetate studied by isolation of [14C]-acetyl enzyme.


The water-soluble polysaccharide of opium poppy (Papaver somniferum L.). Identification of acidic oligosaccharides from a partial acid hydrolysate.


The crystal structure of succinylcholine iodide.


Activation of chymotrypsin by formation of a covalent dimer.


Growth stimulants in plant extracts for Leuconostoc citrovorum. The growth of Leuconostoc citrovorum ML 34, an isolate associated with the malo-lactic fermentation of wine, was stimulated in part by grape, orange, cabbage, and tomato juices. The stimulatory activity of tomato serum was associated with the carbohydrate fraction. Further purification of the fraction showed that fructose was the factor responsible for initiating growth. In addition to fructose, the organism required CO(2) for establishing growth. Saturated CO(2) atmosphere and catalytic amounts of fructose served as substitutes for plant extracts in a complex glucose medium.


Metabolic fate of cysteine and methionine in rumen digesta. Estimates were obtained of the extent to which cysteine and methionine were incorporated into the protein of the microbes of rumen digesta without prior degradation and resynthesis. By using the amino acids labeled with both (35)S and (14)C, it was observed that a large proportion of the (35)S appeared in the sulfide pool and of the (14)C appeared in volatile fatty acids. By isolating the appropriate amino acid, obtaining the (14)C to (35)S ratio, and comparing this with the ratio in the added amino acid, the degree of direct incorporation was calculated. For cysteine it was estimated that at most 1% and for methionine, at most 11% of the amino acid in the free pool was incorporated unchanged into microbial protein. As a consequence of these findings, it is considered that the method for measuring microbial protein synthesis in rumen digesta based upon incorporation of (35)S from the free sulfide pool is not seriously affected by direct utilization of sulfur amino acids arising from dietary sources.


Heat resistance of xerophilic fungi based on microscopical assessment of spore survival. An improved viable counting technique was developed to facilitate study of the heat resistance of fungal spores. Spores were heated and subsequently incubated in the same medium. After germination, hyphae and germ tubes were stained with lactofuchsin, and the germinated spores were counted with the aid of a microscope. A number of xerophilic strains were examined, mostly isolates from spoiled highmoisture prunes. Of these, ascospores of Aspergillus chevalieri, A. mangini, and Xeromyces bisporus were the most heat-resistant. A decimal reduction curve obtained for A. chevalieri was specified by a z value of 23 F and an F(180) of 2.2 min.


Sugar substrates for L-lysine fermentation by Ustilago maydis. The extracellular production of l-lysine in media with cane sugar, blackstrap molasses, or clarified sugar-cane juice by a previously obtained mutant of Ustilago maydis was studied. Enzymatically inverted clarified juice (medium J-3) gave 2.9 g of lysine per liter under the following conditions: inoculum, 5%; pH 5.8; temperature, 30 C; K(La) in the fermentors, 0.41 mmoles of O(2) per liter per min; fermentation time, 72 hr. The concentrate, obtained by direct evaporation and drying of the fermentation broth, could be used as a possible feed supplement because of its amino-acid and vitamin content.


Comparative study of 14C-labeled purified protein derivative from various mycobacteria. II. Skin cross-reactivity in sensitized guinea pigs. A study on skin cross-reactivity between stabilized (14)C-labeled mycobacterial antigens, namely tuberculin purified protein derivative (PPD; from Mycobacterium tuberculosis), PPD-A (M. avium), PPD-Y (M. kansasii), PPD-G (M. scrofulaceum), PPD-B (M. intracellulare), and PPD-F (M. fortuitum), has been carried out in groups of guinea pigs sensitized with one of the following heat-killed mycobacteria: M. tuberculosis, M. avium, M. kansasii, M. scrofulaceum, M. intracellulare, or M. fortuitum. For each type of sensitization, the average response for the corresponding PPD antigen was higher than the average response for any of the other antigens. However, the responses to the heterologous PPD antigens were not necessarily significantly different among themselves, and the significant differences of the heterologous PPD antigens were distributed differently according to the type of sensitization. Therefore, (14)C-PPD antigens skin cross-reacted in guinea pigs essentially in the same manner as reported by others for nonradioactive PPD antigens.


Comparative study of 14C-labeled purified protein derivative from various mycobacteria. I. Preparation of 14C-labeled purified protein derivative antigens and their adsorption to glass. Biologically active (14)C-labeled purified protein derivative ((14)C-PPD) has been prepared from the culture filtrates of seven species of mycobacteria, namely Mycobacterium tuberculosis Johnston strain (PPD), M. bovis BCG (PPD-BCG), M. avium (PPD-A), M. kansasii (PPD-Y), M. intracellulare (PPD-B), M. scrofulaceum (PPD-G), and M. fortuitum (PPD-F). These mycobacteria were grown in a culture medium containing a mixture of (14)C-labeled amino acids. The yield and specific radioactivity of the PPD, of the nucleic acid, of the bacterial cells, and of the CO(2) developed during growth have been determined for each of the seven species of mycobacteria. Although the yields of (14)C-PPD antigens differed greatly for the different species of mycobacteria tested, their specific radioactivities were similar. The (14)C-PPD antigens have been used as a means to measure their adsorption to glass. When glass ampoules containing dilute solutions (0.001 mg of PPD per ml) of these PPD antigens (PPD, PPD-BCG, PPD-A, PPD-Y, PPD-G, PPD-B, and PPD-F) were stored for 12 months at 5 C, it was found that they all adsorbed equally well to glass surfaces. In fact, regardless of the origin of the PPD, a loss due to adsorption of about 90% occurred during the first month of storage, and thereafter the PPD content remained practically constant for the rest of the duration of the storage period. The addition of 0.0005% Tween 80 to the PPD solutions effectively reduced the adsorption to glass of most PPD antigens. However, adsorption of PPD-BCG was not quite so effectively prevented, even when the Tween 80 concentration was increased from 0.0005 to 0.0005%.


Penicillic acid production by blue-eye fungi on various agricultural commodities. Of 10 Penicillium species reported to cause blue-eye disease of corn, four (P. martensii, P. palitans, P. cyclopium, P. puberulum) were found capable of producing the mycotoxin penicillic acid on various agricultural commodities. Commodities with high protein contents did not support toxin synthesis. The extent of toxin production varied with the strain of mold, the commodity, and the temperature; low temperatures (1 to 10 C) favored toxin accumulation.


Identification of a stimulant for Lactobacillus casei produced by Streptococcus lactis. A compound stimulatory to the growth of Lactobacillus casei was isolated from cell extracts of Streptococcus lactis, purified, and characterized. The stimulant was identified as a small peptide with a molecular weight of approximately 4,500 daltons. The purified peptide gave negative tests for nucleic acids, phosphorus, glucosamine, and carbohydrates. Sixteen amino acids were detected in acid hydrolysates of this peptide. Serine, proline, glycine, alanine, leucine, and glutamic acid were present in hydrolysates in greatest abundance.


Membrane filtration of the Reiter treponeme. A membrane filtration technique with commercially available membrane filters (Millipore Corp.) was effective for the removal of Reiter treponemes from liquids such as fluorescent-antibody conjugates, to which the organisms are added for adsorption. Reiter treponemes from an 8-day culture were not microscopically detectable in filtrates through membranes with a pore diameter of 0.45 mum, but treponemes were demonstrated in the filtrate by cultural methods. No organisms of the 8-day culture passed through a membrane filter having a pore size of 0.22 mum, as determined by microscopy and culture. Culture data indicated that a filter with a pore size of 0.1 mum was necessary to prevent passage of treponemes from 4-day cultures. It is recommended that a membrane filter with a pore size of 0.22 mum or smaller be used for the removal of Reiter treponemes from suspensions and that the age of the culture be considered in choosing filter pore size.


Detection of mycotoxins by thin-layer chromatography: application to screening of fungal extracts. A convenient thin-layer chromatographic screening procedure for the detection of 18 mycotoxins is described.


Continuous dispenser for multiple-well serological plate. Materials and methods are described for the construction of an inexpensive multiple-well dispensing apparatus for use in serological microtitration.


Destruction of toxic fungi with low concentrations of methyl bromide. Aspergillus parasiticus and Penicillium rubrum spores at the level of 10(4) to 10(5) / g were completely killed by prolonged exposure to 30 to 45 mg of methyl bromide per liter.


Production of specific agglutinins for mycobacteria in peritoneal fluid of mice. Specific agglutinins were produced in ascitic fluid of mice by intraperitoneal injection of certain mycobacteria suspended in Freund's incomplete adjuvant.


Effects of amobarbital sodium on the acquisition and extinction of a lever-press spatial discrimination in the rat.


A method for the determination of small quantities of salicylate metabolites in the presence of a great excess of salicylic acid.


Action of some antibiotics on the extra-hepatic biliary tract. 8. Gentamicin.


Studies on the biotransformation of salicylic acid by the salivary gland.


A comparative study of the Lewis and Sprague Dawley rat in adjuvant arthritis.


Neurodepressant and local anesthetic activity of the quaternary ammonium salt, methyllidocaine chloride.


Uptake and metabolism of noradrenaline--14C in rats after provoking damage to the heart muscle with isoprenaline.


Distribution and metabolism of 14C-metronidazole in mice.


Multicompartment-kinetics and the accumulation plateau.


Lipolytic action of lysine-vasopressin in the adipose tissue of the reserpinized rat.


Normorphine on noradrenaline hypertension.


The effect of inhalation of citral and geraniol on the output and composition of respiratory tract fluid.


Toxicological study of cyheptamide: 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-carboxamide (BS 7029).


Role of endogenous norepinephrine in cardiac inotropic effects of nucleosides.


9,10-dimethyl-1,2-benzanthracene carcinogenesis in the hamster cheek pouch. Inhibitory effect of topically administered cortisone acetate.


Brainstem lesions characteristic of traumatic hyperextension of the head.


Crigler-Najjar syndrome in four of five siblings with postmortem findings in one.


Lysosomal activity of macrophages in leprosy.


Brain lesions in Reye's syndrome.

Brain lesions in Reye's syndrome.


Lymphangiectasis and other pulmonary lesions in the asplenia syndrome.


Accentuation of carbon tetrachloride-induced cirrhosis by azathioprine in the rat.


Diffuse angioendotheliosis. A fatal case in infancy, with clinical and autopsy studies.


Histopathological identification of Entomophthora phycomycosis. Deep mycotic infection in an infant.


Nodular amyloidosis of the lungs. An unusual case associated with chronic lung disease and carcinoma of the bladder.


Chromosomal evidence for the secondary role of fibroblastic proliferation in acute myelofibrosis.


Treatment of aplastic anemia with nandrolone decanoate.


Feedback regulation by red cell mass of the sensitivity of the erythropoietin-producing organ to hypoxia.


Stem cell migration and proliferation during severe anemia.


Reaction of cold agglutinins with I antigen solubilized from human red cells.


Urinary iron excretion in valvular heart disease and after heart valve replacement.


Glucose-6-Phosphate dehydrogenase deficiency in Egypt: with a note on the methemoglobin reduction test.


Erythrocyte glyoxalase II deficiency with coincidental hereditary elliptocytosis.


Statistical analysis of the radial segmentation of lymphocyte and monocyte nuclei in vitro.


Paracervical block in labour.

Paracervical block in labour.


The influence of changes in acid-base balance on neuromuscular blockade in cats.


The effects of variations in end-expiratory inflation pressure on cardiorespiratory function in normo-, hypo-and hypervolaemic dogs.


Coronary artery blood flow in the halothane-depressed canine heart.


The comparative antiarrhythmic effects of mepivacaine and lignocaine.


The amnesic effect of diazepam (Valium).


A source of error in the determination of inhibitor constants of serum cholinesterase.


Electrocardiographic changes during nitrous oxide-oxygen-relaxant anaesthesia in cardiac patients.


The effect of methylphenidate (Ritalin) on post-halothane muscular spasticity.


Effects of spinal anaesthesia and surgery on carbohydrate and fat metabolism in man.


A record number of anaesthetics? A case report.


Studies of drugs given before anaesthesia. XXI. Droperidol.


A disposable anaesthetic face mask.

A disposable anaesthetic face mask.


Movable operating table top for use in tonsillectomy.


The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. 1. Amiodarone (2-butyl, 3-(4-diethylaminoethoxy, 3,5-diiodo, benzoyl) benzofuran hydrochloride), an anti-anginal drug which causes coronary dilatation and depresses myocardial oxygen consumption, was found to protect anaesthetized guinea-pigs against ouabain-induced ventricular fibrillation.2. A 5% (73.4 mM) solution of amiodarone had no local anaesthetic action on guinea-pig skin.3. Amiodarone, 20 mg/kg (29.4 mumol/kg) given daily for 6 weeks intraperitoneally, had no effect on the resting potential or action potential height, and only a small effect on the maximum rate of depolarization, of isolated rabbit atrial or ventricular muscle fibres as shown by intracellular recording. It caused a considerable prolongation of the action potential in both tissues.4. Simultaneous administration of thyroxine (5 mug; 6.26 nmol), given daily for 3 weeks intraperitoneally, prevented the prolongation by amiodarone of the duration of the action potential.5. Treatment of rabbits with 20 mg/kg of amiodarone daily intraperitoneally for 6 weeks had no effect on the weight of the thyroid gland, but was associated with a reduction in body growth rate.6. Treatment of rabbits with 10 mg/kg (60.3 mumol/kg) of potassium iodide (equal in its iodine content to that of 20 mg/kg of amiodarone), given daily for 6 weeks intraperitoneally, had no effect on body growth rate or the duration of cardiac action potentials.7. It was concluded that amiodarone had effects on cardiac action potentials similar to those which occur after thyroidectomy.


Cardiac actions in the dog of a new antagonist of adrenergic excitation which does not produce competitive blockade of adrenoceptors. 1. The cardiac actions of amiodarone, a benzofuran derivative used in the treatment of angina pectoris, have been compared with those of (+/-)-propranolol in anaesthetized dogs.2. After three successive intravenous injections of propranolol, 0.5 mg/kg, had reduced the heart rate by 25%, a fourth dose had no further negative chronotropic action, but amiodarone, 10 mg/kg intravenously, at this point reduced the heart rate by 23%.3. Amiodarone, 10 mg/kg intravenously, reduced, but did not abolish, cardiac responses to isoprenaline, 2 mug/kg intravenously. Subsequent successive injections of 10 mg/kg of amiodarone did not further block the responses to isoprenaline, but propranolol, 1 mg/kg intravenously, abolished them.4. Amiodarone reduced cardiac chronotropic and inotropic responses to glucagon, which were not affected by propranolol.5. Cardiac output was increased 5 min after amiodarone, 10 mg/kg intravenously, but at 10 min and thereafter it did not differ from control values. Propranolol, 1 mg/kg intravenously, reduced cardiac output by 17% at 5 min, and by 30% after 30 min.6. From this and other evidence which is discussed, it is concluded that the cardiac actions of amiodarone are not produced by competitive blockade of beta-adrenoceptors.


A third class of anti-arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474. 1. Both MJ 1999 and AH 3474 protected guinea-pigs anaesthetized with urethane against ouabain-induced ventricular fibrillation.2. MJ 1999 had 1/90, and AH 3474 1/30, of the activity of procaine in reducing the height of the action potential of frog sciatic nerve.3. MJ 1999 and AH 3474 reduced the rate of rise of intracellularly recorded action potentials at concentrations in excess of 160 x 10(-6)M (50 mg/l.). It was concluded that direct depression of depolarization could have contributed little to the protection against ouabain-induced fibrillation.4. MJ 1999, but not AH 3474, greatly prolonged the duration of the action potential in acute experiments on isolated atrial and ventricular muscle, and prolonged the Q-Tc interval of the electrocardiogram in anaesthetized guinea-pigs. It is suggested that this effect contributes to anti-arrhythmic activity.5. At concentrations up to 80 x 10(-6)M AH 3474 had positive chronotropic and inotropic effects on isolated rabbit atrial muscle, but at higher concentrations these were superseded by negative effects. MJ 1999 was depressant at all concentrations studied, the threshold concentrations being 19 x 10(-6)M for chronotropic, and 162 x 10(-6)M for inotropic effects.


Noradrenaline and tyramine action on isolated atrial muscle of endotoxin-treated guinea-pigs. 1. Isolated left-atrial strips of guinea-pigs were driven electrically at a constant rate and log-concentration curves were determined for the positive inotropic effect of noradrenaline and tyramine.2. The atrial tissue from endotoxin-treated animals had a reduced sensitivity to noradrenaline and tyramine.3. After endotoxin, the sensitizing effect of cocaine on the response to noradrenaline was normal but accumulation of (3)H-noradrenaline in nerve terminals was markedly reduced.4. Atrial tissue of endotoxin-treated guinea-pigs responded normally to stretch.


Effects of general depressant drugs on the electrical responses of isolated slabs of cat's cerebral cortex. 1. In the neuronally isolated cortex of the cat, local application of diphenhydramine, promethazine, gammahydroxybutyrate, gammabutyrolactone, gamma aminobutyric acid, hyoscine and pethidine, and the intravenous injection of diazepam and meprobamate depressed or abolished the surface negative and surface positive response to direct stimulation and raised the stimulus threshold of the positive burst response. These effects were the same as previously demonstrated for general and local anaesthetics on the same preparation.2. Chlorpromazine produced a similar depression in small concentrations but caused spontaneous activity in higher concentrations.3. In contrast to local application, pethidine when given by intravenous injection in a high dose produced convulsant activity in the isolated cortical slab. The possibility was suggested that the convulsant activity was produced by a metabolite of pethidine.4. The results of this investigation suggest that the central depression produced by a number of structurally unrelated drugs is indicative of an anaesthetic-like property of these drugs.


Role of the vagus nerves in anaphylaxis and histamine-induced bronchoconstrictions in guinea-pigs. 1. The effects of vagotomy on the respiratory responses of guinea-pigs to anaphylactic reactions and to intravenous injections of histamine acid phosphate are described.2. In spontaneously breathing guinea-pigs, vagotomy reduced by 50% or more the decreases in total lung conductance (bronchoconstriction) and the decreases in lung compliance, and almost abolished the rapid shallow breathing due to histamine.3. In paralysed, artificially ventilated guinea-pigs, vagotomy reduced by more than 33% the decreases in total lung conductance, but had little effect on the changes in lung compliance due to histamine.4. In paralysed, artificially ventilated guinea-pigs, vagotomy reduced by 75% the decrease in total lung conductance and halved the decrease in lung compliance due to anaphylaxis.5. We conclude that a vagal reflex is mainly responsible for the rapid shallow breathing due to histamine, and partly responsible for the bronchoconstrictions due to histamine and to anaphylaxis in guinea-pigs. We suggest that "lung irritant receptors" in the bronchial epithelium are the afferent end-organs involved.


Acetylcholine content in the brain of rats treated with paraoxon and obidoxime. 1. The effect of obidoxime on the rise in brain acetylcholine caused by the anticholinesterase paraoxon was studied in the rat.2. In animals poisoned with a sublethal dose of paraoxon and thereafter treated with obidoxime the levels of both "free" and total brain acetylcholine were practically the same as those in rats injected with paraoxon only.3. After poisoning with doses of paraoxon which are lethal unless an oxime is also given, the total acetylcholine in the brain of obidoxime-protected rats continued to accumulate, reaching a peak 2 h after injection of paraoxon. At this time no signs of central effects such as convulsions or tremor were seen.4. Atropine, given 30 min before paraoxon, markedly reduced the rise in total brain acetylcholine seen when the anticholinesterase is given alone.5. In rats pretreated with atropine and obidoxime excessive doses of paraoxon which are lethal in the absence of the antidotes produced a rise in total brain acetylcholine which was directly proportional to the dose of paraoxon administered.


A comparison of the sensitivities of innervated and denervated rat vasa deferentia to agonist drugs. 1. One vas deferens of a rat was denervated by stripping away the serous coat; the other vas was left intact as a control. One week later the sensitivity in vitro of both vasa deferentia to noradrenaline, adrenaline, dopamine, oxymetazoline or acetylcholine was measured.2. Log concentration response curves for the mean responses of both vasa from a group of four rats for each drug were plotted. Denervated vasa were more sensitive than control vasa to noradrenaline (16-fold), to adrenaline (8-fold), to dopamine (2-fold) and to oxymetazoline (2-fold). Denervated vasa were more sensitive to acetylcholine over the lower half of the concentration range only.3. It is concluded that these results support the theory that at least part of the increased sensitivity of denervated smooth muscle to catecholamines is due to an abolition or reduction of the neuronal uptake process. There is also a small non-specific increase in sensitivity.


Corneal tolerance and insult.

Corneal tolerance and insult.


Uptake, metabolism and release of (3H)-adrenaline by human platelets. 1. Measurements were made of the uptake, metabolism and release of [(3)H]-adrenaline by human platelets in citrated plasma or in an artificial medium.2. Radioactive adrenaline was not taken up at 0-2 degrees C. At 37 degrees C there was a slow uptake which continued for at least 5 hours.3. About half of the radioactivity in the platelets was intact adrenaline. The other half was an acidic metabolite from which adrenaline was released by acid hydrolysis.4. The immediate uptake of adrenaline was proportional to its concentration in the plasma up to at least 1 x 10(-5)M. Uptake measured after 1 h also increased linearly with concentration up to about 1 x 10(-4)M but less with higher concentrations. The highest concentration ratio was about 12.5. The concentration of metabolite in the platelets increased with the concentration of added adrenaline only up to about 2 x 10(-4)M.6. The immediate uptake of adrenaline was partially inhibited by phentolamine and dihydroergotamine. Measurement of uptake both immediately and after 1 h showed that the inhibition produced was not increased beyond about 50% by these drugs or by (+/-)-propranolol, chlorpromazine or amitriptyline up to 1 x 10(-4)M.7. Formation of the metabolite was inhibited by pyrogallol, 8-hydroxyquinoline, or tropolone. This inhibition was associated with a corresponding increase in the adrenaline accumulated intact. Formation of the metabolite was not inhibited by monoamine oxidase inhibitors.8. Reserpine caused a small decrease in the uptake of adrenaline radioactivity in 1 h and a great increase in the proportion recovered as metabolite.9. Thrombin caused the release from platelets of intact adrenaline but not of the metabolite.10. Platelets of albino patients with spontaneous haemorrhages accumulated adrenaline radioactivity at the normal rate but this radioactivity was wholly accounted for by metabolite and not released by thrombin.11. After taking up adrenaline, platelets resuspended in artificial medium at 37 degrees C slowly released both adrenaline and its metabolite. At the same time, the intracellular adrenaline was slowly metabolized.12. The Result suggest that human platelets take up adrenaline by two processes, one of which is inhibited by both alpha- and beta-adrenoceptor blocking agents ad well as by phenothiazines; and that in the platelets adrenaline is partly stored in organelles from which, like 5-hydroxytryptamine, it can be specifically released.


Fitting ultra-thin micro corneal lenses.


Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with L-DOPA. 1. Human blood platelets have been shown to take up dopamine by an energy-dependent, saturable process that is inhibited by 5-hydroxytryptamine (5-HT), desipramine and other drugs.2. Platelets from parkinsonian subjects receiving oral L-DOPA also took up dopamine.3. When the responses of normal and parkinsonian platelets were compared, the parkinsonian cells showed the following differences: increased affinity for the dopamine transport process; decreased equilibrium concentrations of dopamine after incubation for 90 min, and greater efflux of dopamine from loaded platelets during a 10 min incubation.4. There were no differences in the uptake of 5-HT by parkinsonian platelets, but endogenous 5-HT was significantly reduced; ATP was normal.5. In two out of three samples of platelets from parkinsonian subjects, traces of a dopamine-like substance were detected, but this finding requires confirmation.6. If the platelet is a valid model for dopaminergic brain neurones, then the results described would suggest that dopamine uptake and storage may be abnormal in brain neurones in Parkinson's disease.


The effect of high-powered contact lenses on the visual fixation reflex.


Experiences of an ophthalmologist in Portugal with hydrophilic contact lenses.


Changes in the composition of hind limb lymph after chemical injury. 1. Lymph was collected directly from the hind limbs of rabbits and cats anaesthetized with pentobarbitone.2. Injury to the hind limb was caused by injection of one of two chemicals; either dimethylsulphoxide (DMSO) which produced a mild injury, or croton oil which produced severe injury.3. After subcutaneous injection (6 x 0.2 ml) into the right hind limb there was a good correlation between the changes in concentration of intracellular enzyme systems in the lymph draining the limb and the histological appearance of the injured tissue. DMSO caused an increase in cytoplasmic enzymes only, while after croton oil, which caused cell necrosis, there was an increase in the concentration of all intracellular enzymes examined.4. There was an increased lymph flow accompanied by a fall in protein concentration after DMSO, while croton oil caused an increase in protein concentration and a variable effect on lymph flow.


The protective actions of some anticholinergic drugs in sarin poisoning. 1. The central and peripheral anticholinergic activities of a series of drugs comprising atropine, hyoscine, caramiphen and one of its analogues, and three glycollic acid esters, have been measured.2. The ability of the same drugs used alone, and in conjunction with N-methyl pyridinium-2-aldoxime methanesulphonate (P2S), to protect mice, rats and guinea-pigs from the lethal effects of sarin has been assessed.3. No correlation was found to exist between central or peripheral anticholinergic activity and ability to protect from sarin.4. On the indirectly stimulated isolated rat phrenic nerve-diaphragm preparation all drugs with the exception of hyoscine caused potentiation of responses to low frequency stimulation but partial block of responses to high frequency stimulation. The drugs did not reverse the effects of sarin on the phrenic nerve-diaphragm preparation.6. It is concluded that a pharmacological action other than an anticholinergic one is involved, in part, in the protective actions against sarin of some of the drugs studied. Whether their effects on skeletal muscle are of any relevance in this respect is unresolved.


The use of acrylic laminates in fitting impression haptic lenses.


The anterior corneal mosaic.

The anterior corneal mosaic.


Personality, involvement and extremity of judgement.


Cognitive and affective aspects of children's national attitudes.


The rating of psychotherapeutic empathy: a preliminary study.


Current education in contact lens practice.


Autonomic arousal in good and poor premorbid schizophrenics.


Age differences in achievement motivation.


A five- to fifteen-year follow-up study of infantile psychosis. IV. Patterns of cognitive ability.


Personality patterns and levels of dogmatism.


Changing schizophrenic conceptualization by enrichment.


Placental insufficiency.

Placental insufficiency.


Penicillin instability in infusions.

Penicillin instability in infusions.


Abnormal bile or faulty gall bladder?

Abnormal bile or faulty gall bladder?


Ileorectal anastomosis for ulcerative colitis.


Tuberculin anergy.

Tuberculin anergy.


Mesothelioma in Scotland.

Mesothelioma in Scotland. In a retrospective study of the incidence of mesothelioma in Scotland for 1950-67 80 cases were traced from pathological reports and biopsy material of malignant tumours invading the pleura and peritoneum. These cases were matched with two sets of controls. Detailed histories of residence, occupation, and degree of exposure to asbestos confirmed that the incidence of mesothelioma in Scotland is similar to that in other parts of Britain.


Idiopathic hypercalciuria and hyperparathyroidism. With provocative tests of parathyroid activity based on phosphate deprivation and the administration of chlorothiazide 8 out of 19 patients with idiopathic hypercalciuria developed hypercalcaemia. Five of the eight underwent exploration of the neck and four of them had parathyroid adenomas; the fifth patient had "normal" glands but responded satisfactorily to subtotal parathyroidectomy. One patient who failed to develop hypercalcaemia had primary chief cell hyperplasia of the parathyroids.


Glucose tolerance and insulin response in atherosclerosis. Oral glucose tolerance tests were carried out on 51 men with atherosclerotic peripheral vascular disease, none of whom were known diabetics or had suffered recent myocardial infarction. The plasma insulin and blood sugar responses were compared with 47 age and sex-matched controls. There was no significant difference in obesity between the two groups. The patient group showed an increased plasma insulin response with a delay in return to fasting levels, and the blood sugar response was similar. These results suggest that hyperinsulinaemia and hyperglycaemia are often associated with atherosclerosis, and may have a role in its aetiology.


Urinary tract dilatation and oral contraceptives. Six nulliparous patients were found to have overdistensiblity of the upper urinary tract on excretion urography. Of these five had had persistent or recurrent urinary infections. All had been or were receiving oral contraceptives. Though overdistensibility associated with contraceptive therapy is unlikely to be life-threatening, it may be associated with increased patient morbidity.


Anticoagulation by ancrod for haemodialysis. The defibrinating agent ancrod (Arvin) was used instead of heparin for intermittent haemodialysis. It was an effective, and apparently safe, anticoagulant and reduced the deposition of fibrin and leucocytes on the Cellophane membrane. Administration was more complicated and urea dialysance was less with ancrod than with heparin.


Fibrosing alveolitis associated with renal tubular acidosis. The discovery of a case of renal tubular acidosis and fibrosing alveolitis led to the investigation of 19 further patients. Abnormal pulmonary function tests were found in a further four patients with overt renal tubular acidosis and in four out of eight patients with "incomplete" renal tubular acidosis. The response to an ammonium chloride test in seven patients with cryptogenic fibrosing alveolitis was normal. Those patients with a defect of both renal acidification and pulmonary gas transfer had concurrent autoimmune diseases such as Sjögren's syndrome and primary biliary cirrhosis. It is suggested that the renal and pulmonary abnormalities may be part of a systemic disorder capable of affecting many organs. Moreover, hyperglobulinaemia and autoantibodies in these patients further suggests that immunological mechanisms are concerned in the pathogenesis of these abnormalities.


Multiple gastrointestinal haemangiomata.


Reactions of psychiatric outpatients to teaching interviews. In an attempt to assess some of the reactions of psychiatric outpatients attending a teaching clinic, a group of patients who received a letter warning them of the possible presence of students were compared with a group who did not receive such a letter. The "letter" group were generally more satisfied with their interview and were less likely to say that they had consciously withheld information. Greater satisfaction was also expressed by patients over 35.When asked whether they preferred to see one student in private and then the psychiatrist with a small group of other students, or to have the whole interview conducted by the psychiatrist in front of the group, patients expressed a clear preference for the former choice. This former method may also allow more responsible and active participation by the students.


Abortions under the N.H.S.

Abortions under the N.H.S.


Analgesic nephropathy.

Analgesic nephropathy.


Health services financing.

Health services financing.


Length of gestation.

Length of gestation.


Bell's palsy and surgery.

Bell's palsy and surgery.


Rational oxygen therapy.

Rational oxygen therapy.


Vasectomy.

Vasectomy.


Hyperpyrexia after anaesthesia.

Hyperpyrexia after anaesthesia.


Brucellosis in veterinary surgeons.

Brucellosis in veterinary surgeons.


Angina and indomethacin.

Angina and indomethacin.


Expert evidence and evidence of opinion.


Nutritional balance trials with calves experimentally infected with Trichostrongylus axei.


Efficiency of haloxon against some sheep gastro-intestinal nematodes in a coastal region of Tanzania.


Acrosomal abnormality in ram spermatozoa due to heat stress.


The efficacy of various anthelmintics against the parasitic larval stages of Ancylostoma caninum in Mastomys natalensis.


Man, medicine and ecology. An overview.

Man, medicine and ecology. An overview.


The new airborne disease. Community air pollution. Community air pollution is the new airborne disease of our generation's communities. It is caused by the increasing use of fuel, associated with both affluence and careless waste. Photochemical air pollution of the California type involves newly defined atmospheric reactions, is due mostly to motor vehicle exhaust, is oxidizing, and produces ozone, plant damage, impairment of visibility and eye and respiratory symptoms. Aggravation of asthma, impairment of lung function among persons with chronic respiratory disease and a possible causal role, along with cigarette smoking in emphysema and chronic bronchitis, are some of the effects of photochemical pollution. More subtle effects of pollution include impairment of oxygen transport by the blood due to carbon monoxide and interference with porphyrin metabolism due to lead. Carbon monoxide exposures may affect survival of patients who are in hospitals because of myocardial infarction. While many uncertainties in pollution-health reactions need to be resolved, a large number of people in California have health impairment due to airborne disease of this new type.


Is the canary dying? The time has come for man, miner of the world's resources, to surface.


The climax of population growth--past and future perspective.


Everybody's guilty. The ecological dilemma.


Chemicals in the environment.

Chemicals in the environment. Synthetic chemicals are now being incorporated into the earth's ecosystems at a rate and in such manners as to alarm environmentalists. These chemicals are the uncontrolled waste products of a technological society. Most prominent among them at the present time are organochlorine, organomercurial and lead compounds. Persistent members of these groups disperse in water, air and animal tissues. Also they have the capacity for concentration in animal food chains, thereby reversing the historical expectation of the dilution and degradation of wastes. Examples of damage from environmental residues to man are at this stage speculative but documentation from effects on wild species is abundant. Already several species of birds seem on their way to extinction. These wild species constitute a gratuitous monitoring system which already has signaled clear warnings for the welfare of man.


Man-made maladies and medicine.

Man-made maladies and medicine. Man-made, including iatrogenic, maladies are usually unforeseen and may fall into several categories: those resulting from diagnosis and treatment, those relating to social and psychological attitudes or situations, and those emanating from mass programs to control or eradicate diseases. the physician-originated spread of "shipyard eye," tactless behavior toward patients, and lapses in malaria eradication programs. From a presentation of some results from acts of good intention, we may come to anticipate at least some of the unanticipated consequences of health-related interference, much as we are all becoming aware of other consequences of man's tampering with earthly resources.


Ecology as a central discipline in public health.


Ecological health and quality of life now and forevermore.


Myxedema masked by hypoparathyroidism following subtotal thyroidectomy.


Sarcoidosis of the nervous system.

Sarcoidosis of the nervous system. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs. Sydney E. Salmon and Robert W. Schrier, Assistant Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.


The role of ecology in the design of a health care system. The weight of evidence does not support the hypothesis that the health status of the population is largely dependent on the quality and quantity of its medical services. Evidence to test this hypothesis is presented in a conceptual model of the relationship between health and disease and their care systems, suggesting that medical care is largely unrelated to the health status of the population. Examples of disease trends and distribution are presented to support the thesis that ecology is the primary determinant of the health status of the populationData from selected epidemiological studies point to poverty and air pollution as key factors in determining the pattern of mortality in the urban eco-system.


Photocontrol of the orientation of cell division in Adiantum. I. Effects of the dark and red periods in the apical cell of gametophytes.


Perithecial formation in Gelasinospora reticulispora. I. Effects of light at two different growth states.


Skin necrosis associated with warfarin sodium.


An analysis of the effect of "conditioned medium" upon the cell culture at low density.


Changes in the capacity for clonal growth and differentiation in vitro of the vertebral cartilage cells with embryonic development. I. Culture in the standard medium.


Effects of fasting and hypophysectomy on FFA uptake and ketone body production by the isolated, perfused rat liver.


Synthesis of liver glycogen in starved alloxan diabetic rats.


Diabetes incidence: a two-year follow-up of 10,000 men in a survey of ischemic heart disease in Israel.


Diabetic hemorrhagic glaucoma.

Diabetic hemorrhagic glaucoma.


Studies in patients with chlorpropamide-induced hypoglycemia.


CMA's proposal for a voluntary, universally available Health Benefits Program. A socio-economic report of the Bureau of Research and Planning, California Medical Association. The May 4, 1970 issue of the American Medical News contains an article on a report released in April by the British Medical Association following a two-year study of the British National Health Service. Although the BMA study is oriented to the specific program as it has evolved in Great Britain since 1946, its main thrust is in the development of a system of voluntary health insurance which would provide for greater consumer choice, based upon nationally determined guidelines and regulations. BMA's recommendations would have the NHS utilize a combination of tax-supported and voluntary-supported mechanisms in providing medical services to various segments of the population, based upon categories of illness and income levels. Since the BMA proposal as reported in the AMA News parallels in some respects the one approved by the CMA House of Delegates and submitted to the AMA House of Delegates for its consideration, the reader will be interested in seeing the concept for a Voluntary Universally Available Health Benefits Program, independently developed by the California Medical Association. It is interesting to note that the CMA proposal attempts to avoid many of the problems with which the NHS has been identified, and at the same time would establish a single, coherent, integrated approach for development over the next decade, incorporating public programs into a unified system of medical care which utilizes the multiplicity of voluntary health insurance approaches and mechanisms.


Virus particles in a transplantable rat mammary tumor of spontaneous origin.


The influence of host factors on cyclophosphamide treatment of Moloney virus-induced lymphomas.


Tumor growth inhibiting effect of JB-I ascitic fluid. I. An in vivo investigation.


Nucleic acids-hybridization studies in normal and cancer cells.


Pharmaco-biochemical studies on cytotoxic polyol derivatives. II. The effect of biological alkylating agents on the thermal-denaturation properties of DNA.


Effect of insulin and of alloxan diabetes on growth of the rat mammary carcinoma in vivo.


A new ester glucoside from the bark of Tecomella undulata.


Synthesis of 2,2,4,4-tetramethyl-azetidine.


Identification of odorous compounds from male Lepidoptera.


Flavonoids of Gnaphalieae: Leontepodium alpinum Cass.


Effect of a growth-promoting factor on protein synthesis and amino acid transport in vitro.


Fibrous protein ultrastructure of gastropod periostracum (Buccinum undatum L.).


In vivo rupture of the imidazole ring of histamine.


Polymeric collagen isolated from squid (Loligo peallii) connective tissue.


The effect of guanidinosuccinic acid on in vitro carbohydrate metabolism.


Intestinal absorption of D-xylose by germfree rats.


The prosthetic group of the green chromoprotein of Patella ova.


A new plasma kinin in the turtle, Pseudemys scripta elegans.


In vitro incorporation of 14C labeled precursors into swine coronary arterial phospholipids.


Capillarity of red, white and intermediate muscle fibers in trained and untrained guinea pigs.


Divergence of the in vitro and in vivo extracellular space measurements in heart muscle.


A protective mechanism for the tongue: suppression of genioglossal activity induced by stimulation of trigeminal proprioceptive afferents.


Measurement of collateral flow in experimental coronary occlusion.


Exercise, blood lactate and food intake.


Physiologic and pharmacologic responses of mammalian vascular smooth muscles during electric field stimulation.


An assay procedure for mescaline and its determination in rat brain, liver and plasma.


N-(t-aminoalkynyl)-substituted pyrrolidones as oxotremorine antagonists.


Reduction of the quantum content of endplate potentials by atropine.


Action of hydroxychloroquine on the skeletal muscle in vitro.


Fetal encephalopathy following ingestion of tellurium.


Interaction between mycoplasmas and Ehrlich ascites tumor cells.


The amphibian lens: a three month organ culture.


Differential neuronal radiosensitivity as a tool for the study of short connections.


Delayed cutaneous hypersensitivity reaction to tumor-specific antigens of fibrosarcoma in sensitized mice.


Atractyloside does not inhibit the release reaction of blood platelets.


Radiation effects on embryonic chick tibiae.


Normal human blood treated in vitro with cephalothin. Relationship between serologic and metabolic abnormalities of red blood cells.


Agglutinins from Jerusalem sage (Phlomis fruticosa).


The effects of seed extracts on local lesion formation by tobacco necrosis virus.


The innervation of the prothoracic glands of Cerura vinula L (Lepidoptera).


Three probable cases of parthenogenesis in lizards (Agamidae, Chamaeleontidae, Gekkonidae).


The influence of temperature upon the change from the male to the female phase in Ophryotrocha puerilis puerilis, a polychaete worm.


Electron microscopic observation of the balloon-formation of isolated spinach chloroplasts.


Acoustic stimulus perception by the american lobster Homarus americanus (Decapoda).


Tissue sodium and potassium: direct detection in the electron microscope.


Cinephotographic superposition as a technic for the analysis of sub-cellular movement.


Early weaning of buffalo calves. 2. Concentration of total volatile fatty acids and ammonia in the rumen fluid and nitrogenous constituents in the blood.


Inhibition of ovarian compensatory hypertrophy by implants of atropine in the hypothalamus.


Peritoneal fluid cytodifferential changes associated with the administration of cortisone.


Effect of haemagglutinating and mitogenic fractions of phytohaemagglutinin on electrophoretic mobility of lymphocytes and macrophages.


Scanning electron microscopy of the antigen-antibody complex.


Comparative immune response of lentogenic CDF-66 and F strains of Newcastle disease virus.


Self-report scales of hypnotic depth.

Self-report scales of hypnotic depth.


Symposium on the relationship of group psychotherapy to other group modalities in mental health.


Influence of therapeutic task orientation on patient and therapist satisfaction in group psychotherapy.


The comparison of three suggestion techniques for increasing reading efficiency utilizing a counterbalanced research paradigm.


Age regression with unexpected reappearance of a repressed childhood language.


The three-factor theory of hypnosis as applied to the book-reading fantasy and to the concept of suggestion.


Handedness and hypnotizability.

Handedness and hypnotizability.


The challenge to the group psychotherapist created by a society in flux.


Group and family therapy: moving into the present and letting go of the past.


Setting the record straight.

Setting the record straight.


The integrity of a profession.

The integrity of a profession.


Group psychotherapy and group methods in community mental health programs.


The contribution of visual problems to learning disability.


Specificity of the immunological inhibition of the parathyroid hormone activity.


Motor planning and developmental apraxia.


Screening for perceptual dysfunction.

Screening for perceptual dysfunction.


Central and peripheral stimuli regulating sweating during intermittent work in men.


Coronary and systemic hemodynamic effects of glucagon in the intact unanesthetized dog.


Total respiratory compliance in infants and children.


Mechanism of compliance change in excised rat lungs at low transpulmonary pressure.


A small-group approach to individual and institutional change.


Bilateral lung lavage with hyperbarically oxygenated saline in dogs.


Heart rates during 24 hours of usual activity for 100 normal men.


Absorption of bile salts from human gastric mucosa.


Reduction of blood volume by voluntary hyperventilation.


FFA mobilization during and after prolonged severe muscular work in men.


Central circulation during submaximal work preceded by heavy exercise.


Individuation through group psychotherapy.


Diurnal patterns of rats determined by calorimetry under controlled conditions.


Exhausting work limited by external resistance and inhalation of carbon dioxide.


Direct evaluation of convective heat transfer coefficient by naphthalene sublimation.


Temperature regulation of the unanesthetized cat during mild cold and severe heat stress.


Thermal response of human legs during cooling.


Relative viscosity of blood at varying hematocrits in pulmonary circulation.


Tidal volume and respiratory rate changes at start and end of exercise.


Measurement of canine left ventricular performance by cineradiography of the heart.


Radiographic determination of force-velocity-length relationship in the intact dog heart.


Remote switching with latching to selected sites of variable-frequency cardiac pacing.


Digital monitoring of cardiac transmembrane potential characteristics.


Recording of contractile activity of cells in culture.


Rebreathing measurements of pulmonary diffusing capacity for CO during exercise.


FM converter for tape recording of low-frequency biological data.


Estimation of pressure gradient by differential pressure.


Report barometric pressure.

Report barometric pressure.


Catheter-flush system for continuous monitoring of central arterial pulse waveform.


Hybrid computer programming for study of cardiac excitation.


Effect of water pollution control laws on location of dairy products plants in certain United States counties.


Estrone concentrations in the peripheral blood of pregnant cows.


Effects of a stepwise replacement of hay with corn silage on pH, some organic metabolites, and their changes in the rumen fluid of the bovine after feeding.


Effects of dietary protein on blood lipids of the calf with special reference to cholesterol.


From the files of the Committee for the Study of Maternal Mortality.


The cardiac effects of local anesthetics.


Treatment of diabetic retinopathy by photocoagulation.


Neuroblastoma, a study of presenting signs and symptoms.


Tell it like it is doctor. A discussion of reasonable medical probability in Kentucky.


The distribution of triglyceride in subclasses of very low density plasma lipoproteins.


Jejunal absorption of water and electrolytes in inflammatory bowel disease.


Experimental enhancement of lead toxicity by low dietary calcium.


Red cell glucose-6-phosphate dehydrogenase deficiency in Pakistan.


Radiometric analysis of serum and tissue proteins.


A systematic revision of the genus Hirstionyssus (Acari: Mesostigmata) of the Nearctic region.


Variations in the hemoglobin concentrations of Great Basin rodents.


Biology and ethology of Triatoma dimidiata (Latreille, 1811). II. Life span of adults and fecundity and fertility of females.


Laboratory and field studies of the southern house mosquito, Culex pipiens quinquefasciatus Say, infected with the dog heartworm, Dirofilaria immitis (Leidy), in Louisiana.


Population dynamics of Telenomus fariai (Hymenoptera: Scelionidae), a parasite of Chagas' disease vectors. II. Effect of host-egg age.


A new synonym of Ardeicola expallida Blagoveshtchensky (Mallophaga: Philopteridae).


A preliminary note on predation on free-living engorged female Rocky Mountain wood ticks.


A review of Neoschoengastia colombiae Boshell and Kerr, 1942 with descriptions of two new species misidentified with it (Acarina: Trombiculidae: Colicus).


Studies on the preference shown by ovipositing females of Aedes aegypti for water containing immature stages of the same species.


Gigantolaelaps trapidoi, a new neotropical mite (Acarina: Laelapidae).


Radiologic seminar. CI. Roentgen changes in the sella turcica in pituitary tumors.


Youth and drugs.

Youth and drugs.


Amputations in patients with peripheral vascular disease.


Mississippi peer review: the practicing M.D.'s own plan.


Distribution of neural responses to tilting within vestibular nuclei of the cat.


Responses of cat cerebellar Purkinje cells to convergent inputs from cerebral cortex and peripheral sensory systems.


Neural correlates of gustatory intensity and quality.


Attempts to transmit bovine anaplasmosis with Anopheles quadrimaculatus Say (Diptera: Culicidae) and Dermacentor andersoni Stiles (Acarina: Ixodidae).


Localization of visual patterns by neurons in cerebral cortex of the cat.


Somatic and visceral receptive field properties of fibers in ventral quadrant white matter of the cat spinal cord.


Conditioned eye blink: unit activity at coronal-precruciate cortex of the cat.


Conditioned eye blink: gross potential activity at coronal-precruciate cortex of the cat.


Electrophysiological properties and functional interconnections of two symmetrical neurosecretory clusters (bag cells) in abdominal ganglion of Aplysia.


Deformations and thickness variations accompanying spreading depression in the retina.


The meaning of being a Jew in Israel: an analysis of ethnic identity.


Recovery from surgery, with and without preparatory instruction, for three coping styles.


Effects of fear arousal andreassurance on attitude change.


Perceived opportunity, alienation, and drinking behavior among Italian and American youth.


Differential change in affective intensity and the forgetting of unpleasant personal experiences.


Perceptual articulation and task effectiveness in several Israel subcultures.


Environmental effects on interpersonal affective behavior: ambient effective temperature and attraction.


Physical distance and persuasion.

Physical distance and persuasion.


Experimenter-subject "distance" and self-disclosure.


Ecology and environment. 3. Sanitation and housing for industrial workers.


Ecology and environment. 1. Health problems of water management.


Industrial health problems of developing countries. 1. Types of risk and their prevention.


Industrial health problems of developing countries. 2. Use of epidemiological studies in industry to identify health problems and to measure success in overcoming them.


Ecology and environment. 2. Nutrition in industrial populations in the tropics.


Prevention of communicable disease. 1. The control of communicable diseases in rural workers--the role of university departments.


Prevention of communicable disease. 2. The impact of communicable disease on the health of urban workers.


Seminar on care of the newborn. V. Surgical emergencies of the newborn.


Further clarification of Sporotrichum species.


Microbial characteristics of a forest soil after twenty years of prescribed burning.


A platinum resistance thermometer for use in cryobiology.


In vivo determination of the elastic response of bone. I. Method of ulnar resonant frequency determination.


Improved computer chromosome analysis incorporating preprocessing and boundary analysis.


The measurement of iron absorption by whole-body counting.


In vivo determination of the elastic response of bone. II. Ulnar resonant frequency in osteoporotic, diabetic and normal subjects.


A whole-body counter for precision in vivo measurement of radio-iron.


A new three-gate method for measuring 51Cr in the presence of 59Fe in sources in a scattering medium.


Iodine-125, a tracer in cell biology: physical properties and biological aspects.


The quantitative analysis of renograms using the gamma camera.


Degradation of spatial resolution in gamma cameras employing sodium iodide or germanium detectors.


Errors in ferrous sulphate dosimetry.

Errors in ferrous sulphate dosimetry.


The determination of x-ray spectra using attenuation measurements and a computer program.


A hybrid positron scanner.

A hybrid positron scanner.


The on-line application of a small digital computer to a gamma scintillation camera.


The use of "effective" energy to calculate absorbed dose.


Secondary-standard ionization chamber design.


The energy response of LiF, CaF2 and Li2B4O7 to high energy radiations.


On the physical characteristics of 113-In-m.


Calcium kinetics: the philosophy and practice of science.


Values of C lambda for polystyrene and lucite.


A statistically designed colour ribbon for scanners.


Use of epoxy resin in oxygen electrodes.


Effect of thyroid states on amino acid uptake and incorporation in the chicken anterior pituitary.


Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity.


Whole blood ascorbic acid levels in chickens with experimental aplastic anemia and the effect of supplemental ascorbic acid, B 12, and minerals on mortality and pathologic manifestations.


Factors affecting the accumulation of amino acid by the chick intestine.


A study of aflatoxicosis in laying hens.


A system for diurnal heart rate measurement in chickens.


Mercury retention in several strains and strain crosses of chickens.


Effects of an avian ultimobranchial extract in the domestic fowl.


Effect of two levels of buquinolate on endogenous development and oocyst suppression of Eimeria tenella.


Oxygen uptake of mitochondrial isolates from two breeds of chickens and their F cross.


The association of the A, B and E parental blood group system genotypes with fertility and hatchability in chickens.


Seven generations of selection for high and low blood pressure in chickens.


Incorporation of 14C-amino acids into egg proteins by the laying hen.


Toxicity of tannic acid and its metabolites for chickens.


Medical research in the world setting.

Medical research in the world setting.


Medical education and medical migration.


Agriculture, food and nutrition in developing countries.


Provision of medical care in developing countries.


Psychosocial correlates of serum urate levels.


Audiotape and videotape self-confrontation in psychotherapy.


Note on how to choose a visual noise mask.


Note on stress, anxiety and related defenses in a controlled situation.


Responses to intact and intermixed personality inventories.


Changes in ACL scales corresponding to changes in educational levels.


Comparative performance of disadvantaged ethnic and racial groups.


High levels of state or trait anxiety and performance on selected verbal WAIS subtests.


Note on authoritarianism and critical thinking ability.


The California Psychological Inventory as a measurement of permissiveness-restrictiveness and love-hostility.


Self-concepts associated with mania and depression.


Sex differences in the effects of frustration and attack on emotion and vascular processes.


Item ambiguity in the uthoritarianism scales.


Student leadership, mathematics aptitude and college major.


Effect of reverie on recall of word associates.


New approaches to mental health services in colleges and universities.


Role of spatial variables in conditioned conflict.


Aspects of alcoholics' self-concepts as measured by the Tennessee Self-Concept Scale.


Anxiety as a function of task performance feedback and extraversion-introversion.


Audiotape self-confrontation in group psychotherapy.


The need to achieve and the fear of death.


A note on subception.

A note on subception.


Need for control data in studies of self-esteem and persuasibility.


The role of the United Kingdom in world medicine.


Some techniques of behavior modification with an autistic child.


Authoritarian trends in contemporary psychology: the dominance of the paradigm.


Level of aspiration, locus of control and N-achievement in retardates and normal chidren.


Deprivation levels and conditioned suppression.


Characteristics of obese university females who lose weight.


Factor analysis of two personality tests with differing conceptual frameworks.


Authoritarian traits as predictors of candidate preference in 1968 United States presidential election.


Heart-rate response during aversive conditioning.


Water metabolism with prolonged ethanol consumption in the rat.


Acoustic variation and arousal level in infants.


Personality characteristics inventory. I. Factor structure for a combined sample of male and female college students.


Questioning skills among advantaged and disadvantaged children in first grade.


Consistency of performance change and autonomic response as a function of expressed attitude toward a specific stress situation.


The information content of the recovery limb of the electrodermal response.


The cardiac-somatic relationship: some reformulations.


The peripheral mechanism of the galvanic skin response.


Efficiency of GSR detection of information as a function of stimulus set size.


A cat restraining device for the awake animal.


The role of biotin in the nutrition of turkey poults.


Jaundice in the newborn. Case presentation.


Basal cell carcinoma with metastases. Report of two cases.


Infectious mononucleosis and Gaucher's disease in a child.


Segmental infarction of the spinal cord associated with thrombosis of the abdominal aorta.


Local and regional anesthesia in the office.


Peripelvic extravasation with acute ureteral obstruction.


Management of the nephrotic syndrome in children.


Prolapse of the umbilical cord.

Prolapse of the umbilical cord.


Some aspects of constipation.

Some aspects of constipation.


Allergic diathesis in relation to chronic bronchitis.


Assessment of the slow drip infusion technique in cholangiography.


Pancreatic heterotopia.

Pancreatic heterotopia.


The management of scoliosis.

The management of scoliosis.


The effect of insulin upon the secretory response to feeding in dog with selective vagotomy of the parietal cell mass.


The effect of buffered and unbuffered aspirin on gastric pH measured by a pH-sensitive telemetering capsule.


Encephalopathy and portacaval anastomosis.


Results of prolonged insulin tests in patients with duodenal ulcer. Comparison between insulin- and histamine-activated gastric acid secretion.


Pre- and postoperative insulin tests in patients with duodenal ulcer. Comparison with the augmented histamine test.


The content of eosinophil granulocytes in the colonic mucosa in ulcerative colitis.


Serum insulin response to oral glucose in pernicious anemia.


SWITCH--hospital case history on computer.


Repeated insulin tests in patients with duodenal ulcer after truncal vagotomy and pyloroplasty.


The use of computers in assessment of medical students.


Machine recognition in medical microscopy.


Committees or computers.

Committees or computers.


The nonoperative treatment of impacted fractures of the femoral neck.


Smothering in infancy: its relationship to the "crib death syndrome".


Ileal conduit diversion for carcinoma of the bladder.


Mumps arthritis associated with positive latex fixation reaction.


Cancer of the esophagus.

Cancer of the esophagus.


Esophageal stenosis produced by ingestion of bleach: report of two cases.


Aspects of treatment of crisis in myasthenia gravis.


Ocular bobbing.

Ocular bobbing.


Determinants of survival of the dialysis cannula.


Allergic cough syndrome.

Allergic cough syndrome.


Repair of avulsion of medial canthal tendon.


Parathyroid adenoma.

Parathyroid adenoma.


Cosmetic management of selected skin changes of the legs.


One stage management of periurethral abscess complicating urethral stricture.


Pathologist, whither thou goest?

Pathologist, whither thou goest?


Epispadias and vesicoureteral reflux.

Epispadias and vesicoureteral reflux.


Macular and vitreal disturbances produced by traumatic vitreous rebound.


Interferon.

Interferon.


Rapid production of mepacrine resistance in rodent malaria.


Electron microscope studies on the pre-erythrocytic stages of rodent malaria.


Drug sensitivity of exo-erythrocytic stages in pyrimethamine-resistant Plasmodium berghei.


Macrophages and Trypanosoma brucei infections in rabbits.


Pleomorphism demonstrated in a clone of an akinetoplastic strain of Trypanosoma evansi.


Cell mediated immunity in cutaneous leishmaniasis of the guinea-pig.


Use of carbon dioxide instead of agar slopes for preservation of amoebic cultures in BRS medium.


Immunological studies on amoebiasis.

Immunological studies on amoebiasis.


Weber-Christian disease in the differential diagnosis of filariasis.


Yellow fever neutralization tests carried out on blood samples collected on filter paper strips.


Teaching global microbiology.

Teaching global microbiology.


Triple and quadruple hybridization in the Anopheles gambiae complex.


Upper limit in male multiple mating in Anopheles gambiae species A.


Scanning electron micrographs of some mosquito structures.


Two phoretic stimuliids from West Cameroon.


Some tabanids of British Honduras.

Some tabanids of British Honduras.


Screen tests of acaricides for control of the house dust mite.


Dipterous fauna of some Army training areas--Dartmoor 1969.


Increasing malaria during an eradication programme. A study on the tea estates in Assam, 1964-68.


The influence of urinary bilharziasis on vesico-vaginal fistula in relation to causation and healing.


Calcification of the bladder in urinary schistosomiasis.


Haemostasis in kala-azar.

Haemostasis in kala-azar.


Anaemia in Zanzibar.

Anaemia in Zanzibar.


Glucose-6-phosphate dehydrogenase of Schistosoma mansoni.


Cardiovascular disease in a West Malaysian town. A survey in general practice.


Imported schistosomiasis.

Imported schistosomiasis.


Premenstrual pruritus due to recurrent cholestasis.


The early changes in experimental porphyria of mice induced by griseofulvin.


The significance of secondary infection in a skin hospital.


The role of contact allergy in hand eczema.


Acquired hypertrichosis lanuginosa.

Acquired hypertrichosis lanuginosa.


Ultrastructural and light microscopic aspects of lichen planus.


The surgical treatment of oral lichen planus.


Jet gun intralesional therapy.

Jet gun intralesional therapy.


Chronic muco-cutaneous candidiasis.

Chronic muco-cutaneous candidiasis.


Immunodominance.

Immunodominance.


The vocational specialist answer.

The vocational specialist answer.


Fertilizing capacity of frozen boar semen following surgical insemination.


Veterinary surgeons and the E.E.C.

Veterinary surgeons and the E.E.C.


Treatment of established infections of candidasis in partridges with formic acid.


Veterinary Medicine in Indonesia.

Veterinary Medicine in Indonesia.


Radiation disease in hypo- and hyperthyreotic rats.


Incorporation of palmitate-1-14C into lung tissue and "alveolar" lecithin.


Thermal dehydration of the rat: distribution of losses among tissues.


Separation of plasma and platelet factor XIII by gel filtration.


Hepatocellular uptake of inulin, sucrose, and mannitol in rats.


Cerebrospinal and extracellular fluid spaces in turtle brain.


Water and electrolytes during experimental renal and DCA hypertension.


Capillary pressure and filtration coefficient during isoproterenol infusion.


O2 exchange across spleen during asphyxia.


Transport of large molecules from plasma to interstitial fluid and lymph in dogs.


Transformation of hepatic reticuloendothelial cells to erythroid cells by pars intermedia.


Perfusate cations and contracture and Ca, Cr, PCr, and ATP in rabbit myocardium.


Mechanical activity of canine mitral valve in situ.


Minimal preglomerular resistance and calculation of normal glomerular pressure.


Intracellular storage of exportable protein in functionally hypertrophied pancreas.


Effects of reinnervation on denervated skeletal muscle by axons of motor, sensory, and sympathetic neurons.


Tissue amino acid concentrations in rats during acute ammonia intoxication.


Computer simulation of intestinal slow-wave frequency gradient.


Electrical potential difference across proximal convoluted tubules.


Effects of estrogens and progesterone on electrolyte balances in normal dogs.


Renal function in the chinchilla.

Renal function in the chinchilla.


Experimental cardiogenic shock: pulmonary performance after acute myocardial infarction.


Acetazolamide in studying sodium reabsorption in diluting segment.


Metabolism of acetate, propionate, utyrate, and glucose by bovine cerebral cortex slices.


Combined effect of carotid sinus hypotension and digestion on splanchnic circulation.


Cerebral oxygenation and metabolism during progressive hyperthermia.


Tissue resistance of the progesterone-dominated rabbit myometrium.


Oxidative phosphorylation in smooth muscle.


Potassium exchange kinetics in amphibian atrium.


Effect of anions and cations on membrane potential of rabbit corneal epithelium.


Relation between ribosomes and functional growth in the avian nasal gland.


On the resistance of the snail, Lymnaea catascopium pallida (Adams) to concurrent infection with sporocysts of the strigeid trematodes, Cotylurus flabelliformis (Faust) and Diplostomum flexicaudum (Cort and Brooks).


The identification of blood meals in biting midges, (Culicoides: Ceratopogonidae).


Clinical trial of Hetol (1,4-bis-trichloromethylbenzol) in the treatment of opisthorchiasis.


The timing of the first blood meal in Simulium damnosum Theobald.


Glucose-6-phosphate-dehydrogenase-deficiency and malaria in Thailand: the comparison of parasite densities and mortality rates.


A note on variation within Simulium damnosum in the forest zone of West Cameroon.


The chemotherapy of rodent malaria. IX. Causal prophylaxis. I. A method for demonstrating drug action on exo-erythrocytic stages.


The ultrastructure of Leishmania tropica in the oriental sore.


The chemotherapy of rodent malaria. X. Dynamics of drug resistance. II. Acquisition and loss of chloroquine resistance in Plasmodium berghei observed by continuous bioassay.


Serological changes during the acquisition of immunity to Plasmodium vinckei in mice.


The chemotherapy of rodent malaria. XI. Cyclically transmitted, chloroquine-resistant variants of the Keyberg 173 strain of Plasmodium berghei.


Effect of polyacrylic acid on experimental malaria and trypanosomiasis in mice.


The use of electron microscope autoradiography for examining the uptake and degradation of haemoglobin by Plasmodium berghei.


Erythrocyte morphology in blackwater fever.


Comparison of methods for coccidioidomycosis complement fixation. A Laboratory Branch Task Force of the National Communicable Disease Center has proposed a standardized complement fixation procedure (LBCF) and an adaptation of this to microtitration techniques (MT) as uniform methods for performing complement fixation (CF) tests. A common procedure should make CF results from one laboratory more comparable to another. In addition, it would be preferable if the common procedure reproduced the titer levels of a testing procedure which is to be replaced, particularly when valid clinical interpretations have been derived from the latter. Replicated sets of sera were tested by the LBCF, MT, and the standard Smith CF procedure for coccidioidomycosis. Results with all three procedures were highly reproducible within an acceptable one-tube variation of a twofold dilution series, but the frequency of one-tube variations was greater with the MT method than with the other two. There was no statistical difference in the titers obtained with the Smith and LBCF procedures, but there was a significant difference when the MT results were compared to those with the Smith method. The LBCF method should be acceptable as a standardized and uniform CF procedure for coccidioidomycosis, subject to comparative testing between different laboratories.


Evaluation of liquid nitrogen storage for preservation of group A streptococcal M protein-sensitized sheep red blood cells. Streptococcal M protein-sensitized sheep red blood cells stored in liquid nitrogen showed insignificant change in titer when tested against homologous antisera over a 6-month period. This method eliminates much of the preparation time required for the passive hemagglutination procedure and increases the reproducibility of the test.


Evaluation of phenylene 1,4-diisothiocyanate (Bitoscanate: Jonit) in intestinal parasitic infection: a field study.


Modification of the microtiter technique for antimicrobial drug susceptibility testing by incorporation of indicators. A pH indicator and dextrose were incorporated into growth media as a modification of microbial microtiter methods for determining the minimal inhibitory concentration of antimicrobial drugs. This modified method was tested to evaluate the ease of reading end points by changes in the indicator color. Application of the procedure to two media, three indicators, and eight species of bacteria indicated that definitive end points could be reached as a result of indicator color change caused by acid production during bacterial growth. This method is accurate and reproducible. It is a modification which eliminates a need for plating and facilitates the reading of minimal inhibitory concentration end points.


Microneutralization test for the determination of mumps antibody in vero cells. A sensitive and reproducible test for the determination of mumps serum-neutralizing antibody with Vero cells grown in disposable plastic microtiter plates is described. Serum end point titers obtained by this method showed excellent correlation with those obtained by the primary chick embryo tissue culture-hemadsorption tube test.


Pectic acid lyases of Bacillus polymyxa. Four enzymes were separated from an extracellular preparation of Bacillus polymyxa by carboxymethylcellulose column chromatography. The pH optima were 8.3 to 8.5, 8.7 to 8.9, 9.2 to 9.4, and 9.5 to 9.6. All of the enzymes required calcium ion for maximum activity, whereas strontium ion was only partially effective in stimulating activity. Cobalt was the only other cation tested which was effective in two of the enzymes. The lyases seem to attack a calcium salt-bridged substrate. K(m) and V(m) data of the four enzymes on various oligomers are presented as well as paper chromatographic evidence of preferred sites of attack. All of the enzymes are endo-enzymes which, based upon their characteristics, were classed into two types.


Use of acetone-dried vaccines for preparing capsular antisera against the Klebsiella group and the lyophilization of Klebsiella cultures. Capsular antisera against the 72 types of Klebsiella have been prepared in rabbits by using an acetone-dried vaccine. It was shown that encapsulated cells dried with acetone and ground to a fine powder with a mortar and pestle retain their capsules. Antisera obtained from rabbits vaccinated with these vaccines had quellung titers ranging from 1:16 to 1:64. The dried vaccine was stable after storage for over 2 years at room temperature. Encapsulated cultures lyophilized in the presence of 5% sucrose, 5% sodium glutamate, and 5% polyvinylpyrrolidone remained viable and retained their capsules after storage for 10 months at room temperature.


Preparation of noninfectious arbovirus antigens. Noninfectious arbovirus antigens were prepared from borate-saline suspensions of infected suckling mouse brain buffered with tris(hydroxmethyl)aminomethane and treated with beta-propiolactone (BPL). The activity and stability of these antigens were enhanced by altering the buffering system, by passing the virus seed through a series of four or more continuous passages in the brains of suckling mice, or by a combination of these procedures. The titers of group A and B arbovirus antigens were comparable to titers of antigens extracted by the conventional sucroseacetone-BPL (SA-BPL) method. Antigens prepared from some ungrouped and Bunyamwera arboviruses by either the borate-saline-BPL or SA-BPL method produced inconsistent results and will require the development of more unique procedures to obtain suitable hemagglutinating antigens.


Isolation of a pure dextranase from Penicillium funiculosum. A dextranase, produced by Penicillium funiculosum, was purified 1,000-fold to yield the enzyme which was demonstrated by gel electrophoresis and electrofocusing to be a homogeneous protein. The purification method included acetone partition, ammonium sulfate fractionation, gel filtration, iron defecation and precipitation, and diethylaminoethyl-cellulose chromatography. The pure enzyme was also obtained by preparative gel electrophoresis. Gel-permeation chromatography indicates a molecular weight of 41,000. An isoelectric pH of 4.6 was established by electrofocusing. A 1-mg amount of the enzyme hydrolyzes a dextran substrate to yield 27,000 isomaltose reducing units in 2 hr.


Laboratory studies with a selective Enterococcus medium. Lancefield group D streptococci are involved with appreciable frequency in a variety of infectious processes. The presumptive recognition of these bacteria on initial culturing of clinical specimens is an objective not attained readily by selective media available in the clinical laboratory. Selective Enterococcus agar was evaluated with emphasis on its ability to sequester enterococci from specimens with many microbial components. In addition, the sensitivity of this new agar was compared with Trypticase Soy agar containing sheep blood and Mitis Salivarius agar. All enterococci isolated from clinical material were classified in accordance with accepted biochemical and immunochemical criteria. The enterococci grew on the new medium as distinctive colonies surrounded by a black zone. Only Listeria monocytogenes presented similar colonial morphology after 48 hr. Most other bacteria did not grow at all or appeared markedly different. The sensitivity of the new agar was of the same order of magnitude as on blood or Mitis-Salivarius agars, but its selectivity was superior.


Biological assays for two mycotoxins produced by Fusarium tricinctum. A survey was made to detect microorganisms useful for assaying butenolide [4-acetamido-4-hydroxy-2-butenoic acid gamma-lactone] and T-2 toxin [4beta, 15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxytricothec -9-en-3alpha-ol]. These mycotoxins produced by strains of Fusarium tricinctum have been implicated in mycotoxicosis of livestock. Although butenolide proved to be a very weak antibiotic, assay discs containing 100 mug of this toxin inhibited Sprillum serpens NRRL B-2052, Vibrio tyrogenus NRRL B-1033, and Xanthomonas campestris NRRL B-1459. T-2 toxin had no effect on 54 bacterial strains but inhibited 6 of 11 fungi. Growth of Rhodotorula rubra NRRL Y-7222 and Penicillium digitatum NRRL 1202 was retarded by assay discs containing 4 mug of T-2 toxin. Solutions with less than 1 mug of T-2 per ml toxin were readily detected by a pea seed germination test. Germination was reduced more than 50% when seeds imbibed solutions of 0.5 mug of T-2 toxin per ml. Butenolide had no effect on pea seed germination at concentrations as high as 200 mug/ml.


Stability of antibiotics and chemotherapeutics in agar plates. The stability of chemotherapeutic agents incorporated into agar plates was studied by comparison of minimum inhibitory concentrations on fresh and stored plates and by direct bioassay of the chemotherapeutic agar plates. Plates were stored in sealed bags at 4 C. No loss of bioactivity was demonstrated after 30 days of storage in plates containing methicillin, erythromycin, cephalothin, tetracycline, chloramphenicol, kanamycin, streptomycin, polymyxin B, or nalidixic acid. Penicillin G, ampicillin, and nitrofurantoin showed statistically significant losses of activity after 4 weeks. None of the chemotherapeutics tested showed significant loss in activity after 1 week.


Production of ochratoxin A by Aspergillus ochraceus isolated in Japan from moldy rice. A simple thin-layer chromatography-fluorodensitometric method for quantitative analysis of ochratoxin A was developed. This method proved to be of use in investigating the production of the toxin and the nutritional factors affecting the toxin production by two strains of Aspergillus ochraceus isolated from moldy rice in Japan. These fungi produced large amounts of ochratoxin A in a nutrient solution containing 1% l-phenylalanine and 2% yeast extract.