Evaluation of the Edgegard laminar flow hood. In a horizontal back-to-front flow high-efficiency particulate air-filtered laminar hood, it is shown that a Blake bottle obstruction to the air flow causes a downstream cone of turbulent air which can draw microbial contamination into the work area of the hood. In controlled experiments, contamination with T3 coliphage was reduced by a series of perforations around the open edge of the hood which eliminates the cone of turbulent air. The average reduction in phage counts was 90.75, 86.79, 91.12, and 98.92%, depending upon the site of nebulization. The phage counts were reduced in 48 of the 51 tests.


Environmental and nutritional factors affecting the production of rubratoxin B by Penicillium rubrum Stoll. Rubratoxin B can be produced in a semisynthetic medium by Penicillium rubrum under varying environmental and nutritional conditions. Maximum production (552.0 mg/500 ml) was obtained with P. rubrum NRRL A-11785 grown in stationary cultures of Mosseray's simplified Raulin solution supplemented with 2.5% malt extract broth at ambient temperature. Zinc is required at levels of at least 0.4 mg per liter. In the absence of iron sulfate, there was a 50-fold reduction in rubratoxin B production but not in growth. No toxin was produced by this isolate in 5- or 7-liter fermentors.


Isolation and characterization of a staphylococcal lipase. A number of coagulase-negative staphylococci isolated from human skin were found to produce lipase. Lipolytic activity appeared in the growth medium during the stationary phase of growth but did not appear as a result of autolysis of the cells. Maximal lipase synthesis was obtained when the medium was adjusted to pH 7.5 before inoculation. The purified enzyme hydrolyzed tributyrin and tridecanoin most actively, and a relatively high rate of hydrolysis of triolein was also noted. The optimal activity of the purified lipase was at pH 7.5. The characteristics of the concentrated crude enzyme and purified lipase were compared.


Increased sensitivity of the microbiological assay for biotin by Lactobacillus plantarum. Addition of Tween 80 to biotin assay medium containing acid-hydrolyzed casein as the amino acid source caused marked growth of Lactobacillus plantarum ATCC 8014 in the absence of added biotin. This growth-promoting activity could be eliminated by treating the "vitamin-free" Casamino Acids (Difco) with activated charcoal (Darco G-60) at pH 3.5 for 30 to 60 min. Incorporation of Tween 80 and charcoal-purified Casamino Acids (PCA) into the assay medium (0.8 g and 27 g, respectively, per liter of single strength medium) in place of unpurified Casamino Acids resulted in a medium in which L. plantarum responded to 30 to 50 times less biotin over an extended linear response range (1.3 logs versus 1.0 log) than was required for similar growth in the standard medium. Endogenous growth in the modified medium was absent if the inoculum used was of low density, if it was prepared from biotin-deficient cells, and if the reagents used were free from contaminating traces of biotin. Assays of biological materials for biotin content using the standard medium and the Tween 80-PCA-modified medium resulted in nearly identical values for all samples tested.


Factors affecting the secretion of staphylococcal enterotoxin A. The biosynthesis of enterotoxin A by replicating and nonreplicating cells was investigated. Unlike enterotoxin B, a secondary metabolite, enterotoxin A secretion resembled that of a primary metabolite by being secreted during the exponential phase of growth. The amount of toxin produced per unit of growth was not influenced by NaCl, NaNO(2), or NaNO(3). Several surfactants increased toxin secretion. Toxin secretion by nonreplicating cells was inhibited by chloramphenicol and 2, 4-dinitrophenol but not by streptomycin or penicillin G. The optimal pH for enterotoxin A production was 6.5 to 7.0. The findings suggest a number of possible reasons for the higher incidence of food poisonings caused by enterotoxin A as compared to enterotoxin B.


Differential light scattering measurements of heat-treated bacteria. Effects of heat on diameter, size distribution, and refractive index of Staphylococcus epidermidis suspensions were determined accurately by computer analysis of differential light scattering data.


Chemoprophylaxis of Shigella flexneri keratoconjunctivitis in rabbits. Chloramphenicol, chlortetracycline, streptomycin, and sulfisoxazole prevented keratoconjunctivitis in rabbit eyes infected with Shigella flexneri. The route of administration of the agent and the dose were important variables in controlling the infectious process. This assay system appears to be a useful technique for the in vivo evaluation of chemotherapeutic agents.


Characterization of EO-1 strains (Pseudomonas kingii) isolated from clinical specimens and the hospital environment. Ten strains of the pseudomonad designated EO-1 and named Pseudomonas kingii, which were isolated from clinical specimens and the hospital environment, are described.


Specificity patterns of Agrobacterium tumefaciens phages.


Metabolism of alpha-beta-diaminopropionate in a Pseudomonas sp.


IUPAC-IUB Commission on Biochemical Nomenclature (CBN). Nomenclature for vitamins B6 and related compounds. Tentative rules.


Identification of guanosine 5'-triphosphate and uridine 5'-triphosphate in subcellular monamine-storage organelles.


The regulation of glycollate oxidoreductase with photosynthetic capacity in Chlamydomonas mundana.


Invertebrate connective tissue. Isolation of D-arabinose from sponge acidic polysaccharide. 1. d-Arabinose, an extremely rare sugar in the animal kingdom, was isolated from a complex acidic polysaccharide obtained from the connective tissue of the sponge Hippospongia gossypina. A crystalline derivative of arabinose, the 1-benzyl-1-phenylhydrazone, was prepared and characterized by its melting point, optical rotation, and mixed melting point with authentic d- and l-enantiomers. 2. The distribution of arabinose within the animal kingdom is discussed, and a biological role is proposed for the spongonucleotides.


A comparison between the effects of cold exposure in vivo and of noradrenaline in vitro on the metabolism of the brown fat of new-born rabbits. 1. Exposure of new-born rabbits to the cold leads to an increase in the incorporation of [(14)C]glucose into the glycerol of brown-fat triglyceride, but has no effect on [(14)C]glucose incorporation into triglyceride of white fat or liver. The effect of cold exposure on brown-fat triglyceride is abolished by cutting the cervical sympathetic nerve. 2. Brown fat incorporates very little [(14)C]glucose into triglyceride fatty acids, either in vivo or in vitro. 3. Noradrenaline added to incubations of brown fat from new-born rabbits stimulates O(2) consumption, CO(2) output and incorporation of glucose into triglyceride glycerol. The effects of noradrenaline in vitro are therefore consistent with the hypothesis that noradrenaline mediates the response of the brown fat of new-born rabbits to cold exposure. 4. Glycerokinase is present in the brown fat of new-born rabbits, but its activity is much less than that of the glycerokinase in the brown fat of adult rats. 5. Insulin has no effect on O(2) consumption, CO(2) output or glucose uptake in brown fat of new-born rabbits. 6. It is concluded that the thermogenic response of new-born rabbits to cold exposure is accompanied by a selective acceleration of the triglyceride cycle in brown fat. However, resynthesis of triglyceride would not account for more than 1% of the O(2) consumed in vitro by new-born rabbit brown fat in the presence of noradrenaline if respiration remains coupled to phosphorylation.


The penetration of serum albumin into phospholipid monolayers of different fatty acid chain length and interfacial charge. 1. The highest surface pressure of phosphatidylcholine monolayers allowing penetration of delipidated serum albumin decreased in the order dibehenoyl>distearoyl>dipalmitoyl=dimyristoyl. This pressure was not related to the area occupied or to the space available between the phospholipid molecules at the interface. 2. Penetration of albumin into yeast phosphatidylcholine monolayers was increased by adding a small percentage of long-chain anions (phosphatidic acid, dicetylphosphoric acid) to the film but only when the protein was below its isoelectric point (i.e. positively charged). 3. Stearylamine added to phosphatidylcholine monolayers had no effect on albumin penetration even when the protein was oppositely charged to that of the phospholipid/water interface. 4. The results are discussed in relation to the activation of certain phospholipases by anionic amphipathic substances.


The influence of insulin on the metabolism of glucosamine in the isolated rat diaphragm muscle. 1. The influence of insulin on the metabolism of [1-(14)C]glucosamine by diaphragm muscle from normal rats and rats rendered diabetic with streptozotocin has been studied. 2. The glucosamine was converted into glucosamine 1-phosphate, glucosamine 6-phosphate, glycogen, lactate and small amounts of other unidentified intermediates. 3. Insulin increased the incorporation of (14)C into glycogen in both the normal and diabetic muscle, but did not increase the formation of the glucosamine phosphate esters. 4. The (14)C content in the glycogen was present partly as glucose and partly as glucosamine; there was significantly more [(14)C]glucose in the glycogen of the diabetic muscle than in that of the normal muscle.


An electrophoretic study of the low-molecular-weight components of myosin. 1. The low-molecular-weight components of myosin freshly prepared by the standard procedure from adult rabbit skeletal muscle migrated as four main bands Ml(1), Ml(2), Ml(3) and Ml(4) on polyacrylamide-gel electrophoresis in 8m-urea. 2. The number of bands increased on storage. This change was accelerated by increasing the temperature and pH. 3. None of the bands had electrophoretic mobilities identical with those of the well-characterized proteins of the myofibril or with the sarcoplasmic proteins. 4. By varying the ionic conditions and concentration of muscle mince used for the initial extraction it was possible to change the relative proportions of the two electrophoretic bands of intermediate mobility, Ml(2) and Ml(3). 5. The four-band picture similar to that obtained with rabbit was observed with myosin isolated from skeletal muscle of the rat, mouse, hamster, pigeon and chicken. 6. Rabbit cardiac myosin gave only two bands on electrophoresis. Myosin from rabbit red muscle gave a pattern intermediate between cardiac and white-skeletal-muscle myosin, i.e. the two fastest bands were present in decreased relative amounts. 7. It is suggested that the differences in the low-molecular-weight components of myosin from different types of muscle are a consequence of differences in the isoenzyme composition of the myosins.


Ketone body and fatty acid metabolism in sheep tissues. 3-Hydroxybutyrate dehydrogenase, a cytoplasmic enzyme in sheep liver and kidney. 1. 3-Hydroxybutyrate dehydrogenase (EC 1.1.1.30) activities in sheep kidney cortex, rumen epithelium, skeletal muscle, brain, heart and liver were 177, 41, 38, 33, 27 and 17mumol/h per g of tissue respectively, and in rat liver and kidney cortex the values were 1150 and 170 respectively. 2. In sheep liver and kidney cortex the 3-hydroxybutyrate dehydrogenase was located predominantly in the cytosol fractions. In contrast, the enzyme was found in the mitochondria in rat liver and kidney cortex. 3. Laurate, myristate, palmitate and stearate were not oxidized by sheep liver mitochondria, whereas the l-carnitine esters were oxidized at appreciable rates. The free acids were readily oxidized by rat liver mitochondria. 4. During oxidation of palmitoyl-l-carnitine by sheep liver mitochondria, acetoacetate production accounted for 63% of the oxygen uptake. No 3-hydroxybutyrate was formed, even after 10min anaerobic incubation, except when sheep liver cytosol was added. With rat liver mitochondria, half of the preformed acetoacetate was converted into 3-hydroxybutyrate after anaerobic incubation. 5. Measurement of ketone bodies by using specific enzymic methods (Williamson, Mellanby & Krebs, 1962) showed that blood of normal sheep and cattle has a high [3-hydroxybutyrate]/[acetoacetate] ratio, in contrast with that of non-ruminants (rats and pigeons). This ratio in the blood of lambs was similar to that of non-ruminants. The ratio in sheep blood decreased on starvation and rose again on re-feeding. 6. The physiological implications of the low activity of 3-hydroxybutyrate dehydrogenase in sheep liver and the fact that it is found in the cytoplasm in sheep liver and kidney cortex are discussed.


Osmometry with single sephadex beads.

Osmometry with single sephadex beads. 1. The measurement of osmotic pressure by means of a single bead of Sephadex (Edmond, Farquhar, Dunstone & Ogston, 1968) has been made more precise by immobilizing the bead on a fine needle. The design, calibration and use of the osmometer are described. 2. The method is particularly suitable for measuring high osmotic pressures in solutions of high-molecular-weight solutes, which must not penetrate the Sephadex to a significant extent. 3. With Sephadex G-50 the limit of precision is about 1.5cmH(2)O and the lower limit of molecular weight for a solute of compact molecular form is about 10(5). 4. The time required for each equilibration is less than 10min. 5. An impaled bead can be stored in the dry state without affecting its calibration. 6. Measurements on a sample of polyvinyl alcohol, degree of polymerization stated as 1750+/-50, gave m(n) 43000+/-3000 and A(2) (6.0+/-0.24)x10(-4).


Aspects of carnitine ester metabolism in sheep liver. 1. Carnitine acetyltransferase (EC 2.3.1.7) activity in sheep liver mitochondria was 76nmol/min per mg of protein, in contrast with 1.7 for rat liver mitochondria. The activity in bovine liver mitochondria was comparable with that of sheep liver mitochondria. Carnitine palmitoyltransferase activity was the same in both sheep and rat liver mitochondria. 2. The [free carnitine]/[acetylcarnitine] ratio in sheep liver ranged from 6:1 for animals fed ad libitum on lucerne to approx. 1:1 for animals grazed on open pastures. This change in ratio appeared to reflect the ratio of propionic acid to acetic acid produced in the rumen of the sheep under the two dietary conditions. 3. In sheep starved for 7 days the [free carnitine]/[acetylcarnitine] ratio in the liver was 0.46:1. The increase in acetylcarnitine on starvation was not at the expense of free carnitine, as the amounts of free carnitine and total acid-soluble carnitine rose approximately fivefold on starvation. An even more dramatic increase in total acid-soluble carnitine of the liver was seen in an alloxan-diabetic sheep. 4. The [free CoA]/[acetyl-CoA] ratio in the liver ranged from 1:1 in the sheep fed on lucerne to 0.34:1 for animals starved for 7 days. 5. The importance of carnitine acetyltransferase in sheep liver and its role in relieving ;acetyl pressure' on the CoA system is discussed.


Pancreatic pathology, chemically defined liquid diets and bacterial flora in the rat.


Selective inhibition of glucose oxidation by triethyltin in rat brain in vivo. Results are reported of a comparative study in vivo of the metabolism of [2-(14)C]-glucose and [1-(14)C]acetate in brains of rats intoxicated with triethyltin sulphate. The incorporation of (14)C from glucose into glutamate, glutamine, gamma-aminobutyrate and aspartate was greatly decreased. The incorporation of (14)C from acetate into these amino acids was unaffected. The experimental data indicated that the main action of triethyltin was to decrease the rate at which pyruvate formed from glucose is oxidized. Glycolysis was not inhibited. Changes in glucose metabolism in the brain are shown not to be directly due to hypothermia. Some of the advantages of measuring the labelling of intermediates at very short time intervals after the injection of the labelled glucose are demonstrated.


N-phenyl anthranilic acid: an agent for inducing and studying renal papillary necrosis in the rat.


Production of experimental models of foetal growth retardation by inhibition of DNA or protein synthesis.


Some observations on the effects of vitamin C deficiency on bone.


The influence of haemodynamics on the structure and organisation of experimental red thrombi.


Malaysian medical students: intellectual performance and ethnic background.


Growth in the rat's brown fat of a Hodgkin's-like transplantable reticulo-endothelial tumour.


A first degree in clinical science.

A first degree in clinical science.


Platelet adhesion to subendothelial components in experimental aortic injury. Role of fine fibrils and basement membrane.


The application of anatomy and other basic medical sciences in general practice.


A teaching methods course in Liverpool for general practitioners.


An approach to the teaching of clinical biochemistry.


The effects of reserpine depletion of circulating vasoactive amines on rabbit serum sickness.


A self-testing device as an aid to learning.


A method for keeping student records and its application to the evaluation of examinations.


The roles of medicine and social science in the future health services of Britain.


Medical education in Taiwan.

Medical education in Taiwan.


Overseas tutor scheme in medical laboratory technology.


Reorganization of the British National Health Service.


A linear educational study on the intake of a single year into medical school.


Women students in Canadian medical schools.


Influence of environmental factors on height and weight of schoolchildren.


The dynamics of a long-stay mental hospital population.


Changes in mean birth weight and proportion of low-weight births in Hungary.


Maternity unit admissions policy and the use of simulations.


'Clustering' of multiple sclerosis cases by date and place of birth.


Deaths of children in Greater London 1966.


The Yerkes-Dodson law and alimentary motivation.


Results and costs of a computer-assisted immunization scheme.


Territorial imperative.

Territorial imperative.


Creativity and the need for associative novelty.


Multiple standardization of parasuicide ('attempted suicide') rates in Edinburgh.


Management of intractable angina pectoris by implantation of a carotid sinus nerve stimulator. This paper discusses the management of patients with intractable angina pectoris, and describes the first year's experience with implantation of a carotid sinus nerve stimulator. Seven patients had such stimulators installed; all showed objective evidence of stimulator action through a drop in blood pressure and/or pulse rate. All seven have since shown considerable improvement, enabling them to lead more comfortable lives. One patient derived initially little benefit; this was traced to a mechanical failure of the device which was corrected. However, this patient died of an acute myocardial infarction 15 months after the operation.


Christmas tree allergy: mould and pollen studies. A history of respiratory or other allergic symptoms during the Christmas season is occasionally obtained from allergic patients and can be related to exposure to conifers at home or in school. Incidence and mechanism of production of these symptoms were studied. Of 1657 allergic patients, respiratory and skin allergies to conifers occurred in 7%. This seasonal syndrome includes sneezing, wheezing and transitory skin rashes. The majority of patients develop their disease within 24 hours, but 15% experience symptoms after several days' delay. Mould and pollen studies were carried out in 10 test sites before, during and after tree placement in the home. Scrapings from pine and spruce bark yielded large numbers of Penicillium, Epicoccum and Alternaria, but these failed to become airborne. No significant alteration was discovered in the airborne fungi in houses when trees were present. Pollen studies showed release into air of weed, grass and tree pollens while Christmas trees were in the house. Oleoresins of the tree balsam are thought to be the most likely cause of the symptoms designated as Christmas tree allergy.


Improving Canada's medical aid to developing countries: a role for the social sciences.


A cold-weather "jogging mask" for angina patients.


Experience with home dialysis using arteriovenous fistulas.


Cor pulmonale secondary to talc granulomata in the lungs of a drug addict.


Uncommon causes of sciatica.

Uncommon causes of sciatica.


Ectopic pregnancy following hysterectomy.


Deaths in drug addicts.

Deaths in drug addicts.


Bill 41: the end of an era?

Bill 41: the end of an era?


Gun-shot wound of abdomen (case P66).

Gun-shot wound of abdomen (case P66).


Too many children or too many pediatricians?


Abortion.

Abortion.


Manifestations of pinworms.

Manifestations of pinworms.


Rectal absorption of progesterone and testosterone in rabbits.


Microbial content in a non-sterile concentrated haemodialysis solution.


Identification of barbiturates in blood by gas chromatography.


Studies on particle size problems. VI. Fundamentals on pharmacopoeial control of particle size in the sub-sieve range.


Chlamydospore development in the absence of protein synthesis in Fusarium solani.


DNA polymerase activity in rat brain during ontogeny.


A microphotometric study of myogenic lizard cells grown in vitro.


Temperature-sensitive mutations in drosophila melanogaster. VI. Temperature effects on development of sex-linked recessive lethals.


An analysis of developmental fields.

An analysis of developmental fields.


An interplay of genetic and environmental factors in familial hepatitis and myasthenia gravis. A family is described in which there occurred two cases of the lupoid type of active chronic hepatitis with cirrhosis, one of chronic persistent hepatitis, and one of myasthenia gravis. The two cases of lupoid hepatitis were in the proposita, a schoolgirl aged 16 years, and her great-aunt aged 69 years whom she had never met. The case of myasthenia gravis was that of the father. The whole family, except the great-aunt, had been exposed to an epidemic of infectious hepatitis five years previously, and the girl and her brother had contracted this disease. The schoolgirl later developed active chronic hepatitis while her brother had chronic persistent hepatitis without immunological concomitants. APART FROM COINCIDENCE, SOME COMBINATION OF THREE PROCESSES WAS REQUIRED TO ACCOUNT FOR THE ILLNESSES IN THIS FAMILY: a genetic predisposition to chronic liver disease in particular, a genetic predisposition to autoimmune reactions in general, and a ;triggering' effect of infection with the hepatitis virus.


A case of the Dubin-Johnson syndrome complicated by acute hepatitis. A patient is described in whom the Dubin-Johnson syndrome was diagnosed after an attack of acute hepatitis at the age of 21. In the eight years following the hepatitis Dubin-Johnson pigment, initially scanty, developed to classical proportions. The defect in intracellular transport of bilirubin was thought to precede the attack of acute hepatitis.


Idiopathic acute fatty liver of pregnancy. A maternal survivor of idiopathic fatty liver, with the characteristic histological appearance on liver biopsy, is reported. Profound hypoglycaemia was the major complication in this patient and it is suggested that more attention should be given to the blood glucose in this disease. The consideration of future pregnancy in this patient is discussed.


Recurrent acute retrograde intragastric intussusception. A case of recurrent acute retrograde jejunogastric intussusception is described in a 45-year-old man who five years previously had had an antecolic gastrojejunostomy. Two previous haematemases imply that this complication was recurrent and self reducing an unusual and fortuitous outcome. Awareness of the possibility of acute intussusception following gastroenterostomy or partial gastrectomy is stressed.


Dose response relationships of insulin hypoglycaemia and gastric acid in man. Fourteen studies of gastric acid secretion in a basal hour and in the two hours after a single intravenous injection of soluble insulin (0.01 to 0.40 units/kg) were performed in a healthy man. The peak acid output after insulin (measured as the two consecutive 15-minute samples giving the highest acid output) was significantly correlated with the lowest concentration of blood glucose, the fall in blood glucose, the rate of fall of blood glucose, and the maximum fall of blood glucose in any 15 minutes. Peak acid outputs after insulin were similar over the range 0.1 to 0.2 units/kg, and greater than at lower or higher doses. These results are contrary to the accepted assumption that insulin-stimulated acid secretion is an ;all-or-none' phenomenon. They support instead the hypothesis that insulin hypoglycaemia provides a quantitative glycopenic stimulus producing quantitative vagal acid response. Extreme hypoglycaemia, below about 15 mg/100 ml of blood glucose, inhibits insulin-stimulated acid secretion.


Histological localization of plasminogen activator and proteolytic activity in the human stomach and duodenum. Plasminogen activator activity has been localized in gastric and duodenal tissue using a histological technique. This activity could be separated from proteolytic activity by incorporating in-aminocaproic acid into the fibrin substrate or by heat treatment. Plasminogen activator activity was found in relation to mucosal and submucosal blood vessels in the tissues studied. Proteolytic activity was identified in the surface epithelium, the gastric antral and fundal glands, and in the antral submucosal fat. Proximal duodenal tissue contained proteolytic activity in relation to Brunner's glands.


The interrelationships of pancreatic enzymes in human duodenal aspirate. The interrelationships of proteolytic enzymes and amylase have been studied in the duodenal aspirate obtained from subjects with normal and abnormal pancreatic function during stimulation with secretin and pancreozymin. While the relationship of trypsin to chymotrypsin was independent of stimulus and presence of pancreatic disease the ratio of proteolytic enzymes to amylase rose when the degree of stimulation of the pancreas was increased. Patients with recent acute pancreatitis and with chronic pancreatitis tended to have more severe impairment of secretion of proteolytic enzymes than of amylase. In routine tests of pancreatic function both proteolytic and non-proteolytic enzymes should be measured, both because an abnormal ratio may be of diagnostic significance and because the two different groups of enzymes provide mutual checks of the secretory capacity of pancreatic enzymes.


Gastric leiomyoblastoma.

Gastric leiomyoblastoma. This paper describes two cases of gastric leiomyoblastoma (bizarre smooth muscle tumour), one of them having evidence of metastases. Both patients remain well after seven years and three and a half years respectively. The literature is reviewed, and the clinical features, diagnosis, and treatment are discussed. The histological appearances are described in detail and an attempt is made to assess the criteria for the diagnosis of malignancy.


Immunochemical characterization of submicrosomal rat liver esterases.


Molecular forms of antigen in the circultion following immunization.


Antibody-ligand interactions studied by fluorescence enhancement methods. II. Binding properties of anti-azonaphthalenesulfonate antibodies.


A note on brucellosis in and around Calcutta.


Fat studies on normal Indian adults: effect of dietary fat on excretion of fat in faeces.


Experimental study on bonding of tissues in mammals with epoxy resin.


Anti-inflammatory activity of saponins and ot-her natural products.


An epidemiological study into sickness absence in a textile mill in Delhi.


A study of infant mortality in Luckow Cantonment.


Optical components of the normal eyes in Indians. 3. Depth of the anterior chamber.


Environmental health and ecology: old concepts with new meaning for man's survival.


Animal technicians and the veterinarian.


Evaluation of thiamylal sodium, succinylcholine, and glyceryl guaiacolate prior to inhalation anesthesia in horses.


Evaluation of closed, semiclosed, and nonrebreathing inhalation anesthesia systems in the horse.


Effects of succinylcholine and promazine on the cardiovascular and respiratory systems of horses.


Pregnancy diagnosis in swine utilizing the vaginal biopsy technique.


Economic analysis of a feeder cattle preconditionin program.


Beef production on irrigated alfalfa pastures.


An anabolic agent for ruminants.

An anabolic agent for ruminants.


Bovine inhalation anesthesia.

Bovine inhalation anesthesia.


Nigropallidal encephalomalacia in horses caused by ingestion of weeds of the genus Centaurea.


Endodontic therapy for canine teeth in the dog.


The university and the city.

The university and the city.


Veterinary Medicine in civil affairs and the world hunger problem.


Food for the '70's.

Food for the '70's.


A veterinary view of consumer protection.


Regulatory aspects of animal welfare legislation.


Military consumer protection.

Military consumer protection.


The center for population research.

The center for population research.


Progress toward improved modified live-virus vaccines.


The continued education and training of regulatory veterinarians.


Progress of the cooperative state-federal inspection programs under the wholesome meat act.


Fumigation or famine.

Fumigation or famine.


Spontaneous oral papillomatosis in rabbits.


Fiber spectrum and functional propertis of pyramidal tract neurons in the American opossum.


New decontamination efforts and techniques for elimination of Salmonella from animal protein rendering plants.


Ecology and the veterinarian.

Ecology and the veterinarian.


A quantitative ultrastructural study of the inner plexiform layer of the rat retina.


A study of single dose tolbutamide therapy in diabetes mellitus.


Pharmacological action of the biflavonoids fromthe gymnosperms with special reference to Ginkgo biloba, L. A survey.


Pattern of ischaemic heart disease: a clinical study.


Follow-up study of inguinal hernia in adults repaired by dividing the spermatic cord in the inguinal canal.


Some assorted cases of non-neoplastic intracraniallesions.


Medical journalism.

Medical journalism.


Learning by simulation. The validation of disaster simulation: medical scheme planning.


Pattern of ischaemic heart disease in India.


Low voltage in carcinoid syndrome.

Low voltage in carcinoid syndrome.


Chronic granulomatous disease of childhood.


Medical record guide.

Medical record guide.


Medicine and government.

Medicine and government.


Research vs. social medicine? Demands of society upon medical research.


Clinical management of patients with prosthetic valves.


Surgical treatment of abdominal aortic aneurysms.


Health statistics used in "errati numbers game".


Preventing death in a ditch.

Preventing death in a ditch.


From out of the past.

From out of the past.


Angiography in cancer detection.

Angiography in cancer detection.


Ethical aspects of "the final revolution": mind manipulation and Judaeo-Christian ethics.


Physician attitudes toward hospital abortion in Georgia--1970.


Clinical cardiology. Tetralogy of Fallot.


The individual member, the County Socity, andthe Medical Association of Georgia.


Mallet finger. A review of the literature.


The abortion survey.

The abortion survey.


Angina pectoris two hundred years later.


The 5 s RNA genes of Drosophila melanogaster.


The 3'-termini of bacteriophage Q-beta plus and minus strands.


Segments of genome of viruses containing double-stranded ribonucleic acid.


Denaturation at the right-hand end of the DNA molecule of lambda bacteriophage.


IUPAC-IUB Commission on Biochemical Nomenclature. Abbreviations and symbols for the description of the conformation of polypeptide chains.


Initiation of the polypeptide chain in the rII B cistron of bacteriophage T4.


Nucleotide clusters in deoxyribonucleic acids. VI. The pyrimidine oligonucleotides of strands r and l of bacteriophage lambda DNA.


Composition and structure of chromosomal and amplified ribosomal DNA's of Xenopus laevis.


Electrophoretic characterization of nucleolar RNA from Chironomus tentans salivary gland cells.


Nucleotide clusters in deoxyribonucleic acids. V. The pyrimidine oligonucleotides of strands r and l of bacteriophage T7 DNA.


The petite mutation in yeast. Loss of mitochondrial deoxyribonucleic acid during induction of petites with ethidium bromide.


Reconstruction of three-dimensional images from electron micrographs of structures with helical symmetry.


Reactivities of the tryptophan residues of alpha-lactalbumin and lysozyme to 2-hydroxy-5-nitrobenzyl bromide.


Structures of deoxy- and carbonmonoxy-erythrocruorin.


Isolation of open-circular DNA molecules by retention in agar gels.


Co-operative non-enzymic base recognition. I. Thermodynamics of the helix-coil transition of oligoriboadenylic acids at ACIDIC PH.


Studies on aggregation of embryonic cells: initial cell adhesions and the formation of intercellular junctions.


Structure and function of mammalian ribosomes. II. Exchange of ribosomal subunits at various stages of in vitro polypeptide synthesis.


Effect of cycloheximide on the nucleolar RNA synthesis in rat liver.


Seasonal ovarian histology of the ovoviviparous iguanid lizard Sceloporus jarrovi Cope.


Structure and function of mammalian ribosomes. I. Isolation and characterization of active liver ribosomal subunits.


The lizard ear: Scincidae.

The lizard ear: Scincidae.


An electron microscopic study of the spermathecal complex of virgin Aedes aegypti mosquitoes.


Chemosensitive hairs in spiders.

Chemosensitive hairs in spiders.


The segmentation of the gnathobdellid leeches with special reference to the Indian leech Hirudinaria and medicinal leech Hirudo.


An attempt to separate a sheep pineal extract fraction showing antigonadotropic activity.


Fluorescence histochemical investigation on the adrenergic innervation of the white adipose tissue in the rat.


Cardiovascular reactions to orthoclinostatic conditions in children of various age.


Separation of pineal extracts on sephadex G-10. I. A spectrofluorimetric study of indoles in a cockerel pineal extract.


Instigation to aggression as a function of degree of defeat and the capacity for massive retaliation.


Individual differences in verbal conditioning, extinction, and awareness.


Evidence for a curvilinear relationship between complexity and originality.


Personality caracteristics of college students on academic probation.


A field experiment in interpersonal persuasion using authoritative influence.


Self-esteem and the effects of success and failure feedback n performance.


The structure of mood: a comparison between sleep deprivation and normal wakefulness conditions.


Encoding and decoding of nonveral affect in humans.


Deindividuation in the small group: further evidence.


Social comparison, self-consistency, and the concept of self.


Leader complexity and leadership style.

Leader complexity and leadership style.


Heart rate and skin conductance during experimentally induced anxiety: the effect of uncertainty about receiving a noxious stimulus.


Combining information about people: comparisons between six models.


A national mental health manpower showcase conference: NAMH leads the way.


Case studies of volunteer programs in mental health.


The new professionals practical aspects of the use of New Careerists in public service agencies.


Education of the community mental health assistant: dovetailing theory with practice.


Mental health professionals' hang-ups in training mental health counselors.


The clergyman's role and community mental health.


The first-year psychiatric resident and the professional identity crisis.


Problems and pitfalls of establishing an Operant Cnditioning-Token Economy program.


Reaching the deaf: report of an in-hospital group.


Social intervention--consultation to organizations.


Fees and mental health services: attitudes o the professional.


Community cooperatin and a shoestring budget: Rx for an activity therapy program.


Characteristics of community residents who are favorable toward alcohol education.


Organization of mental health services and its effect on the treatment career of the patient.


The wider field of work of the National Committee for Mental Hygiene.


Social adequacy of state mental hospital patients.


A psychiatric training program for high school students assigned to a geriatric service.


From psychiatric aide to psychologist.

From psychiatric aide to psychologist.


Stability of attitudes in psychiatric attendants following training.


We need sheltered workshops for former metal patients.


Psychiatric disorders in young women: the public health implications.


Effects of the Baltimore riots on psychiatric hospital admissions.


Doing it in the road: folkways vs. mores.


Primary prevention: a challenge to Mental Health Associations.


The need for differentiation in rehabilitating the mentally retarded.


What happened to the family?

What happened to the family?


[Production of antibiotics by geophilic dermatophytes. II. The antibiotic spectrum of crude filtrate].


Chronic paronychia, and oral and vaginal candidal carriage.


Tinea capitis in infants. (A survey of 70 cases).


The hypocrealean fungi (Ascomycetes, Hypocreales).


Glucose inhibition and inheritance of pigment-producing ability in Phytophthora.


Soil microfloral interactions with aflatoxin synthesis and degradation.


A method for nutritional support of patients with severe renal failure.


Body fat and muscle tissue in Dutch adolescent boys and young adult men, assessed by anthropometry.


The effect of ascorbic acid on cholesterolemia in healthy subjects with seasonal deficit of vitamin C.


Effec of fasting on external pancreatic secretion in volunteers.


Bioevaluation of dietary iron in growing rats. IV. Response of rats to a simulated Finnish diet with and without iron and copper supplementation.


Effect of dietary linoleic acid on vitamin E requirement and fatty acid composition of erythrocyte lipids in rats.


Some effects of thiamine deficiency on food selection in the rat.


Conidial discharge in Protomycopsis thirumalacharii.


The effect of testosterone on chemical carcinogenesis in the buccal pouches of castrated and intact male hamsters.


The "Cordless" mobile x-ray machine.

The "Cordless" mobile x-ray machine.


A new instrument for measuring dose-rate.


The analysis of cineradiographic records of movements of the temporo-mandibular joints.


Overlap and coverage in arteriography with moving table-top technique.


Rheumatoid arthritis in the Bantu.

Rheumatoid arthritis in the Bantu.


Anhidrotic ectodermal dysplasia: presentation in the neonatal period.


The evolution in South Africa of the concept of 'climate asthma' and of the associated climate patterns.


Vagotomy of the parietal cell mass: experimental study and preliminary report in fifteen patients.


Pulmonary function studies using radio-isotope xenon-133.


Oedema of obscure origin: a report of two cases.


Left ventricular akinesis: experimental production, hemodynamic effects, and results of excision.


Clinical trials of hycanthone (etrenol) in urinary tract bilharziasis.


Penicillin-induced haemolytic anaemia: a case report.


Gastric bypass and pancreatic secretion.


Experimental effects of selective arteriography on the microcirculation.


Creative time.

Creative time.


Time in particle physics.

Time in particle physics.


Tme in statistical physs and speial relativity.


Evaluation of circadian dyschronism during transmeridian flights.


Blood flow measurements in aorto-coronary artery saphenous vein bypass grafts.


Homograft replacement of the aortic valve.


Open heart surgery in elderly patients.

Open heart surgery in elderly patients.


Removal of intra-uterine foreign body.

Removal of intra-uterine foreign body.


Prosthetic replacement of the aortic valve: a current assessment of operative results.


Landmark case.

Landmark case.


Pre-coronary care, 1970.

Pre-coronary care, 1970.


Congenital radio-ulnar synostosis. Report of 37 cases.


Bone changes in parathyroid adenoma. Report of a case.


Bone strain in the tibia during normal quadrupedal locomotion.


Osteoid osteoma and osteoblastoma. Closely related entities of osteoblastic derivation.


Tissue surrounding grafted tendons in dogs. A pathomorphologic study.


Anterior cervical fusion for cervical rhizopathies. A follow-up study.


Fractures of radial head and their treatment.


A new compression plate for high femoral osteotomy for osteoarthritis of the hip. Preliminary report.


Treatment of fractures of the femoral shaft.


Synovial pH in rheumatoid knee joints. II. The effect of local corticosteroid treatment.


Shortening in pseudarthrosis. Treatment with the Küntscher distractor.


Correlation between noradrenaline release and effector response to nerve stimulation in rat portal vein in vitro.


Effect of vagotomy on gastric emptying.

Effect of vagotomy on gastric emptying.


Impaired renal function exaggerates hyperbilirubinemia in bile duct-ligated dogs.


Rapid duodenal intubation employing a wire guide.


Achalasia or carcinoma? The significance of the mecholyl test.


Toxic dilatation of the colon in granulomatous colitis. Report of 2 cases.


The syndrome of bronchial mucocele and regional hyperinflation of the lung.


Bronchocele and blocked bronchiectasis.

Bronchocele and blocked bronchiectasis.


Multiple pulmonary fibroleiomyomatous hamartomas. Report of a case and review of the literature.


Nephrobroncholithiasis. Report of a case secondary to renal lithiasis with a nephrobronchial fistula.


The roentgen manifestations of thoracic actinomycosis.


Roentgenographic measurements of diaphragmatic motion-respiratory compliance.


A characteristic pulmonary finding in unilateral complete bronchial transection.


Roentgenographic appearance of aorto-coronary artery by-pass using a reversed saphenous vein.


Phlebography in the prevention of recurrent pulmonary embolism--techniques and value.


Reversibily of left ventricular dysfunction following aorto-coronary by-pass grafts.


Roentgenographic measurement of arterial narrowing.


Transposition of the great arteries. Determination of the position of the great arteries in conventional chest roentgenograms.


Pitfalls in the ultrasonic diagnosis of pericardial effusion.


Renal agenesis--roentgenologic problem.

Renal agenesis--roentgenologic problem.


Renal emphysema. A case report and review of the literature.


Total hip replacement. Roentgen appearance of current devices.


Double-contrast arthrography in the diagnosis of pigmented villonodular synovitis of the knee.


Gastric tuberculosis. Report of a case with discussion of angiographic findings.


Bone changes in chronic adult Gaucher's disease.


Transfemoral superselective celiac angiography.


Celiac epinephrine enhanced angiography.


Intestinal lymphangiectasia.

Intestinal lymphangiectasia.


Submucosal lymphatic cysts of the gastrointestinal tract: a rare cause of submucosal mass lesion.


Abdominal lymphography: a study with special reference to the individual variations in dosage of contrast medium.


The juxta-alveolar lymphatics in the human adult lung. Histologic studies in 15 cases of drowning.


Capillary density: alveolar diameter, a morphometric approach to ventilation and perfusion.


Idiopathic pulmonary hemosiderosis. Ultrastructural abnormalities in the capillary walls.


On the factors influencing consistency in the radiologic diagnosis of pneumoconiosis.


A study of gas analysis for measurement of pulmonary diffusing capacity for carbon monoxide by chromatographic techniques.


Measurement of alveolar carbon dioxide tension at maximal expiration as an estimate of arterial carbon dioxide tension in patients with airway obstruction.


Relationship of bronchitis and emphysema to altered pulmonary function.


Pulmonary phycomycosis. Report of a case of bronchocutaneous fistula formation and pulmonary arterial mycothrombosis.


The effect of anemia on pulmonary diffusing capacity with derivation of a correction equation.


A simple, rapid technique for assessing airway resistance during quiet breathing.


Normal macrophage function in pulmonary alveolar proteinosis.


An oropharyngeal loop to guide nasotracheal intubation.


Ethnic variation in forced expiratory volume and forced vital capacity of African and Indian adults in Guyana.


Specificity in skin reaction to tuberculin protein prepared from rapidly growing mycobacteria and some nocardia.


Early lung cancer.

Early lung cancer.


A preliminary investigation of some immunologic aspects of tobacco use.


The tuberculin unit.

The tuberculin unit.


Oxygen therapy in cardiopulmonary disease.


Standards for tuberculosis treatment in the 1970's.


Effect of timing of vagal stimulation on heart rate in the dog.


Potentiation by anticholinesterases of the response of rat mesenteric arteries to sympathetic postganglionic nerve stimulation.


Studies on the pathogenesis of hypertensive vascular disease. Effect of high-pressure intra-arterial injections in rats.


Longitudinal gradients in periarteriolar oxygen tension. A possible mechanism for the participation of oxygen in local regulation of blood flow.


Local regulation of vascular cross section during changes in femoral arterial blood flow in dogs.


Prostaglandin-like substances appearing in canine renal venous blood during renal ischemia. Their patial characterization by pharmacologic and chromatographic procedures.


Role of lysosomes in the pathogenesis of splanchnic ischemia shock in cats.


Increased cardiac output as a contributory factor in experimental renal hypertension in dogs.


Direct current make and break thresholds for pacemaker electrodes on the canine ventricle.


Effects of blood pressure and blood viscosity on fluorescein transit time in the cerebral microcirculation in the mouse.


Protective role of increased myocardial glycogen stores in cardiac anoxia in the rat.


Minor pyrrolizidine alkaloids from Cynoglossum officinale L.


Ampoule for freeze-drying of pharmaceuticals with stopper inserted below flame-sealing.


Longitudinal distribution of blood in the rabbit in relation to the heart, with observations on the contribution of different organs.


Studies on particle size problems. V. Surface area stabilities of micronized powders in relation to humidity and heat sterilization.


Lessons from the sea for gastroenterology. The presidential address.


Amiloride (MK-870), a new antikaluretic diuretic. Comparison to other antikaluretic diuretics in patients with liver disease and ascites.


Sulfobromophthalein tolerance test in patients with Dubin-Johnson syndrome and their relatives.


Insignificance of the enterobiliary circulation of lecithin in man.


Canalicular bile flow and bile secretory pressure. Evidence for a non-bile salt dependent fraction in the isolated perfused rat liver.


Granulomas in suction biopsies of distal duodenum. An aid in the diagnosis of "granulomatous enteritis".


Histological diagnosis by peroral biopsy of Crohn's disease of the proximal intestine.


Eosinophilic gastroenteritis: a simple reaction to food allergens?


Gastric reflux during perfusion of the proximal small bowel.


An assessment of models for pancreatic secretion.


An unusual case of ischemic enteritis mimicking regional enteritis.


Volume, composition, and source of intestinal gas.


Morphometric analysis comparing junctional and oral epithelium of normal human gingiva.


Enzymatic hydrolysis and structure of water-insoluble glucan produced by glucosyltransferases from a strain of streptococcus mutans.


Clinical pharmacology: a bridge to better treatment.


Standards.

Standards.


Repair of the mitral valve after rupture of chordae tendineae.


Problems arising from alcohol in the New Hebrides.


Debrisoquine. A five-year study of a new hypotensive agent.


Acute renal failure due to overdosage of colistin.


Asthma and specific learning difficulty.


The period spent in hospital for appendicectomy.


Observations on dysphagia.

Observations on dysphagia.


Partial inhibition of aurotoxicosis by calcium.


Possible role of Aspergillus flavus in the pathogenesis of Schneeberg and Jáchymov disease.


A study of chromosomal behaviour in primary tumour cells and lymphatic metastases under the action of the cytostatic IOB 82.


The effect of chlorambucil on the incorporation of tritiated precursors into the nucleic acids and proteins of Yoshida ascites sarcoma cells.


Presence of antitumorous autoantibodies in the blood of BALB-c mice with methylcholanthrene-induced sarcoma.


Properties of the sarcomas induced by ferridextran Spofa in inbred rat strain AVN. II. The observation of H-1a and B 1 antigenity of FEDEX-AVN-3 tumour following long term in vitro cultivation.


Effect of progesterone on endometrial cancer in the organ culture.


Macroscopic characteristics of cancer of the fallopian tube.


Abuse of amphetamine and amphetamine-like drugs.


A double-barrel approach to modification of homosexual behavior.


Effect of avoidance-avoidance conflict on startle magnitude.


Smoking, extraversion, and neuroticism.

Smoking, extraversion, and neuroticism.


Optimism-pessimism as a consequence of success or failure in children.


Influence of dyadic interaction on creative functioning.


Effect of instructions and internal-external control of reinforcement on a conditioned finger-withdrawal response.


Transparency or pseudo-transparency on the subscales of the Self-perception Inventory.


Treatment of smoking by covert sensitization.


Intermittent reinforcement, guilt, and crime.


Workshop in communication for members of a psychiatric team.


Clinical judgment as fantasied identification.


Personality pattern of depression and its relation to acquiescence.


Note on the role of neuroticism and extraversion in the "nice personality" stereotype.


Extra-list errors in paired associate learning by retarded and normal children.


Multivariate analysis of attitudes and personality characteristics among 60 youthful offenders.


Status integration and suicide.

Status integration and suicide.


Personality and intellective predictors and academic success in an independent study science course at the college level.


Commonality of word association response in schizophrenia as a function of premorbid adjustment, chronicity, and paranoid status.


A denotative dimension of meaning for the mentally ill-healthy role in society.


Anomie and the suicidal individual.

Anomie and the suicidal individual.


A good, short measure of religious dogmatism.


High and low levels of dogmatism in relation to personality, intellectual, and environmental characteristics of medical students.


Comment on "the effects of modified programmed lectures and mathematical games upon achievement and attitude of ninth-grade low achievers in mathematics".


Temporal stability of the PPVT in normal and educable-retarded children.


Effects of insulin, metrazol, and electroconvulsive shocks upon learning to learn 30 successive reversal problems by rats.


Internal-external control of reinforcement in smoking behavior.


Significant intercorrelations among measures of overinclusive thinking.


Validity test of the dogmatism scale.

Validity test of the dogmatism scale.


Another note on political candidate preference and authoritarianism.


Creativity: reported family patterns and scoring methodology.


Religious orientations of three samples of graduate students in clinical psychology, social work, and counseling and guidance.


Pro-rationalization: a defence mechanism.


Personality correlates of the duration of menses.


Interpersonal trust and delinquency: a reply to Rotter.


Effects of video playback of a person on his self-concept.


Discriminant analysis.

Discriminant analysis.


High-voltage electrophoresis in urinary amino acid screening.


The effect on the nitrogen balance of the ratio essential-non-essential amino acids in intravenously infused solutions.


Pyroglutamic aciduria--a new inborn error of metabolism.


Arterial noradrenaline concentration during exercise in relation to the relative work levels.


Respiratory compensation to metabolic acid-base disturbances.


Muscle metabolites during submaximal and maximal exercise in man.


Dimerisation of bilirubin diglucuronide and formation of a complex of bilirubin and the diglucuronide.


Synthesis of phospholipids and triglycerides in human liver slices. II. Influence of preoperative fructose load.


Simultaneous registration of ventilation and perfusion of the right and left lung in rabbits with a radiospirometric technique.


A system for identification and distribution of samples and for processing and storage of data in clinical chemistry.


Respiratory function after spontaneous pneumothorax in relation to treatment.


Residual volume determined by single breath dilution of helium at various apnoea times.


Alveolar volume and transfer factor determined by single breath dilution of a test gas at various apnoea times.


Choice of therapy in spontaneous pneumothorax in relation to later cardiopulmonary function.


The modified Gersuny procedure for urinary diversion.


Trauma to the parotid region.

Trauma to the parotid region.


Ion selection by burn eschar.

Ion selection by burn eschar.


Carcinoma in the other breast.

Carcinoma in the other breast.


Compound fracture of the tibia.

Compound fracture of the tibia.


Familial nephritis and associated deafness in a southwestern Apache Indian family.


Safe management of the child with a contracted neck: a new method.


Reading epilepsy: case report and review of the literature.


Drug and environmental effects on DDT residues in human blood.


Preemption of parental authority by grandparents and its destructive effect upon the family.


Meningococcal disease.

Meningococcal disease.


Divorce and children.

Divorce and children.


An improved technic for ureteroneocystostomy.


The natural history of adenomatous rectal polyps.


Economic progress in people of Appalachia.


Studies on the viability of sporozoites of Eimeria tenella.


[Excystation and infection experiments with coccidian oocysts in newborn animals].


Chirodiscus amplexans Trouessart & Neumann redescribed (Acari: Listrophoridae).


Biosynthesis of ribonucleic acid in mitochondria of rye (Secale cereale) leaves in vitro.


Branched-chain aminotransferase in brain tissue.


Purification of yellow lupin seed tRNA's specific for isoleucine and some other amino acids.


Genetic analysis by transduction of Rhizobium meliloti mutants with changed symbiotic activity.


Studies on the effect of constant magnetic field on tobacco mosaic virus synthesis in tobacco leaves.


The relationship between arylesterase activity and growth in rats.


Effect of prostaglandin E1 on fat mobilizing lipolysis in rat adipose tissue in relation to the nutritional condition.


Synthesis of noradrenaline from 3,4-dihydroxyphenylalanine (DOPA) and dopamine in adrenergic nerves of mouse atrium--effect of reserpine, monoamine oxidase and tyrosine hydroxylase inhibition.


Effects of some adrenergic neuron blockers, related quaternary ammonium compounds and guanidine derivatives on degenerating adrenergic nerves in the conscious rat.


Cytoplasmic distribution of endogenous and exogenous 5-hydroxytryptamine in rat peritoneal mast cells.


The effect of periarterial nerve stimulation on the jejunal and ileal motility in cat.


Circulatory effects of interruption and stimulation of cardiac vagal afferents.


The role of vagal cardiac nerves and arterial baroreceptors in the circulatory adjustments to hemorrhage in the cat.


Contraction times of twitches evoked by H-reflexes.


Fate of 3H-noradrenaline in canine subcutaneous adipose tissue.


In vitro assay of the stimulatory effect of hypoxic serum on cellular proliferation in the erythron.


Preferential secretion of newly formed noradrenaline in the perfused rabbit heart.


Ocular manifestations in collagenoses (with colour plates I and II).


Pathological aspects of Adie's syndrome.


Pathophysiology of reproductive failure after clomiphene-induced ovulation. 70 patients with infertility were evaluated after clomiphene-induced ovulation to determine the cause of the low rate of conceptions and subsequent viable pregnancies.  Ovarian function was measured employing the usual clinical techniques.  In a select group of 4, plasma luteotropic hormone, follicle stimulating hormone, progesterone, and 17-hydroxyprogesterone were measured an ovarian biopsies were obtained.  From these studies, 2 groups could be defined.  The 1st was found to have normal luteal function followed by a relatively high incidence of successful pregnancy.  The 2nd group demonstrated abnormal luteal function with only 1 successful pregnancy.  Ovarian biopsies from 2 patients in the 2nd group showed inadequate luteinization of the granulosa cells, a finding which appeared to correlate with abnormal gonadotropin stimulation.  These data would suggest that gonadotropin requirements for adequate corpus luteum function are separate from those required for ovualtion.


Estriol concentrations in blood during pregnancy.


Cross-implantation of tumor tissue and cross-transfusion in patients with advanced cancer.


Prognosis, malignancy, and curability of the germ-cell tumor occurring in dysgenetic gonads.


Pathogenicity of Trichomonas vaginalis. a clinical and biologic study.


Thermal aspects of uterine blood flow in nonpregnant sheep.


Plasma cortisol levels and cortisol binding in normal and pre-eclamptic pregnancies.


An automated collecting and measuring device for uterine blood flow studies.


Split products of fibrin in maternal serum in the perinatal period.


Prematurity and low birth weight litters: a mechanism elicited by thermal stress.


Virilization in pregnancy associated with an ovarian mucinous cystadenoma.


The relationship between progesterone, uterine volume, intrauterine pressure, and clinical progress in hypertonic saline--induced abortions.


Maternal and fetal disorders in pregnancies of mothers of twins.


Leukocyte alkaline phosphatase and fetal prognosis in placental dysfunction.


A comparative study of a screening test for bacteriuria.


Premature rupture of the fetal membranes confirmed by intra-amniotic injection of dye (Evans blue T-1824).


Regulation of arginine biosynthesis in Chlamydomonas reinhardii: studies in vivo and of ornithine transcarbamoylase and argininosuccinate lyase activities.


The utilisation of galactose by an Aspergillus nidulans mutant lacking galactose phosphate-UDP glucose transferase and its relation to cell wall synthesis.


Purification of monotrichous flagella of Vibrio parahaemolyticus.


Immunological properties of Chikungunya virus and its components.


Electric and hydrodynamic properties of polypeptides in solution. II. Conformation of poly(L-glutamic acid) in various organic solvents.


Optical activity of aromatic chromophores. I. O, m, and p-tyrosine.


The influence of single-strand breaks on the kinetics of denaturation of DNA.


Electro-optic scattering studies on deoxyribonucleic acid.


Studies on bacteriophage MS2. 8. Evidence for dimer formation of MS2 RNA by reaction with formaldehyde at acidic pH.


Buoyant density and solvation of magnesium DNA.


Nature of the charge carriers in solvated biomacromolecules: DNA and water.


Differences in fluorescence spectra of acridine orange-DNA complexes related to DNA base composition.


Cyclophosphamide therapy of idiopathic nephrosis. Thirty-three children with steroid-dependent or steroid-resistant idiopathic nephrosis were treated with a combination of cyclophosphamide and prednisone. Remission occurred in all 23 steroid-dependent patients and, at last report, 12 had gone without any medication for periods of from two months to 21 months without relapse. Remission occurred in five of ten steroid-resistant patients. The renal biopsy findings in these patients demonstrate a correlation between the "minimal change" lesion and a positive response to cyclophosphamide.


The clinical spectrum of meningococcal disease. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs. Sydney E. Salmon and Robert W. Schrier, Assistant Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.


The treatment of anovulatory infertility.


Recent progress in cervical oncology.

Recent progress in cervical oncology.


Amniocentesis in the assessment of fetal maturation.


"Come and go" aspiration abortion.

"Come and go" aspiration abortion.


Clomid in the treatment of oligo-amenorrhea.


Antenatal diagnosis of genetic disease.

Antenatal diagnosis of genetic disease.


Septic abortion--current management.

Septic abortion--current management.


Squamous dysplasia of the uterine cervix.


Rupture of the membrane before the 36th week of pregnancy.


Fetal monitoring for the practicing physician.


Outpatient dilatation and curettage.

Outpatient dilatation and curettage.


Clinical significance of folic acid metabolism in pregnancy.


The chain reaction of health care legislation 1965-1970.


Minors and the physician.

Minors and the physician.


Bacteriuria--prevention at what cost?

Bacteriuria--prevention at what cost?


Health care pollution?

Health care pollution?


Popollution--are we all guilty? The higher and higher wisdom.


Nature's statement of facts.

Nature's statement of facts.


If we hurry we may be late.

If we hurry we may be late.


On "chemicals in the environment".

On "chemicals in the environment".


Semantic pollutants.

Semantic pollutants.


Long range expectations for the health delivery system.


Methadone maintenance for opiate dependence. The use of the synthetic opiate methadone on a continuing maintenance scheduled is unquestionably the most successful and most widely applicable treatment for the control of opiate dependence. Though the medical aspects of the treatment are simple, the nature of the medication and the nature of the problems of opiate dependence are such that administration of a program requires careful attention. Because the problem is so serious both to society and the addict, it is urgent that we develop and adequate number of well run methadone programs throughout the state and the nation.


Peer review. Cost control or quality control?


Continuing medical education. A survey among physicians practicing in San Diego and Imperial Counties. Patterns of continuing education of 244 physicians practicing in San Diego and Imperial Counties were studied by means of an interview questionnaire. An additional 20 internists and general practitioners were observed for one week in order to check the validity of the questionnaire findings.All physicians reported that they engaged in one or more means of continuing education and about three quarters had attended at least one formal course during the preceding three years. Almost all (99 percent) had attended some hospital-based teaching conference, tumor board or professional society meeting during the year preceding interview and 88 percent had attended at least once each month. Physicians in group practice participated more regularly in continuing education than those in solo practice, but no differences in participation were observed between those practicing in the metropolitan area of San Diego and those practicing in the other areas of the two counties. Different patterns of continuing education by specialty are also reported and the attitudes of physicians toward continuing education are described.


Wheezing and bronchial asthma.

Wheezing and bronchial asthma.


Not method but fortuity.

Not method but fortuity.


Cardiomyopathies.

Cardiomyopathies.


The subendocardium of the left ventricle, a physiologic enigma.


Continued progress in the treatment of histoplasmosis.


Never on Sunday.

Never on Sunday.


Pharmacology of a new antianginal drug: perhexiline. 3. Bronchopulmonary system in the dog and humans.


Follow-up of patients with chronic pulmonary histoplasmosis treated with amphotericin B.


The differential response to infection of autogenous vein versus dacron arterial prosthesis.


Pseudocoarctation of the aorta: a variant or an entity?


Miliary tuberculosis: diagnostic methods with emphasis on the chest roentgenogram.


Pharmacology of a new antianginal drug: perhexiline. I. Coronary circulation and myocardial metabolism.


Thrombogenic experience with intravascular heat exchangers.


The phonocardiogram in systemic hypertension.


Arrhythmias in myocardial infarction. Diagnosis and treatment (No. 7).


The management of acute respiratory failure in a respiratory intensive care unit.


Single coronary artery; origin from the pulmonary trunk in association with ventricular septal defect.


Pulmonary tuberculosis with giant radiolucency.


Anomalous origin of the left coronary artery from the right pulmonary artery associated with ventricular septal defect.


Brush holder for endoscopy.

Brush holder for endoscopy.


Unilateral hyperlucent lung.

Unilateral hyperlucent lung.


Atrial septal defect in a nonagenarian.

Atrial septal defect in a nonagenarian.


Chemical characterization of tetanus toxin and toxoid. Amino acid composition, number of SH and S-S groups and N-terminal amino acid.


Coat protein repression of bacteriophage M12 RNA directed polysome formation.


Neutral steroids in urine during pregnancy. Identification of sulphate-conjugated 3-beta,15-alpha-dihydroxy-5-alpha-pregnan-20-one, 3-beta,15-alpha-dihydroxy-5-beta-pregnan-20-one and 5-pregnene-3-beta,15-beta,17-alpha,20-alpha-tetrol.


Acid protease from germinated sorghum. 2. Substrate specificity with synthetic peptides and ribonuclease A.


The partial specific volume of chymotrypsinogen A in aqueous urea solutions.


Acid phosphomonoesterase from Phaseolus mungo. Purification and characterization.


The phosphoglycerate kinase reaction and its metal ion specificity.


The biosynthesis of polyunsaturated fatty acids by photosynthetic tissue. The composition of phosphatidyl choline species in Chlorella vulgaris during the formation of linoleic acid.


On the morphology of phytohemagglutinin from Phaseolus vulgaris seeds.


The stereochemistry of alpha-oxidation of fatty acids in leaves. The formation of carbonyl intermediates.


The amino acid sequence of the beta-chains of rabbit hemoglobin.


Large scale purification of A-protein from bacterior17.


Immunological properties of amylose, dextran and polyvinylalcohol conjugated with polytyrosyl-peptides.


Vocal initiation. High speed cinematographic studies on normal subjects.


Phonation quotient in patients with laryngeal diseases.


The monosynaptic spinal cord reflex activity changes in stuttering.


Certain speech characteristics of mentally retarded children.


Cell-mediated immunity against antigens common to human colonic carcinomas and fetal gut epithelium.


Tumor-associated immunoglobulins. The elution of IgG2 from mouse tumors.


The formation of variants with a reversion of properties of transformed cells. V. Reversion to a limited life-span.


Effects of prolactin or growth hormone on growth of carcinogen-induced mammary tumors of adreno-ovariectomized rats.


A prospective trial of the TNM classification of breast cancer by the regional cancer treatment centres in Ontario, 1960-1964.


Effect of neuraminidase on electrophoretic mobility and immune cytolysis of human uterine cervix carcinoma cells.


Near-infrared circular dichroism of an iron-sulfur protein. D leads to d transitions in rubredoxin.


A solid-phase synthesis of (8-arginine)-vasopressin through a crystalline protected nonapeptide intermediate and biological properties of the hormone.


Some model reactions and a general mechanism for flavoenzyme-catalyzed dehydrogenations.


Coarctation of the aorta and cerebrovascular accident: a proposal for early corrective surgery.


Pulmonary valvular atresia with intact ventricular septum: problems in diagnosis and results of treatment.


The genesis and significance of digital and palmar hand creases: preliminary report.


Effects of pH and protein concentration on the molecular weight of human chorionic somatomammotropin.


Pycnodysostosis: a case report of a child with associated trisomy X.


Failure of phototherapy to reduce serum bilirubin in newborn infants.


The relationship of koilonychia and iron deficiency in infants.


The alkaline bleaching of Pseudomonas fluorescens azurin.


Lysergic acid diethylamide (LSD) and exstrophy of the bladder.


The effect of methyldopa on plasma renin activity in a child with Bartter's syndrome.


On the nature of the equilibrium product of the reaction between pyridoxal 5'-phosphate and bovine serum albumin. Evidence against sulfhydryl participation.


Nucleic acid synthesis in rat fetal liver.


Juvenile GM2 gangliosidosis: partial deficiency of hexosaminidase A.


The pediatrician and his patient: prescribing medication for pediatric patients.


Thiamine deficiency presenting as opisthotonus.


Rubella as a possible cause of diastrophic dwarfism.


Systemic lupus erythematosus and ethosuccimide.


Maternal thiazides and platelet counts of neonates.


Relationship of phototherapy and skin color.


Pseudolymphoma induced by diphenylhydantoin.


Gaucher cells in leukemia.

Gaucher cells in leukemia.


Familial dysautonomia.

Familial dysautonomia.


Secondary and prolonged fevers in bacterial meningitis.


A protracted hospital-associated outbreak of salmonellosis due to a multiple-antibiotic-resistant strain of Salmonella indiana.


Patterns and determinants of maternal attachment.


Cortical hyperostosis with hyperphosphatemia: a new syndrome?


Observations on cystic fibrosis of the pancreas. VI. The uterine cervix.


Inhibition of desaturation of stearic acid in livers of rats fed ethionine.


Fatty acid composition of the neutral lipids and individual phospholipids of muscle of cold-stressed arctic mice.


Effect of culture temperature on fatty acid composition of Chlorella sorokiniana.


Cerebrosides of rabbit and pigeon aorta: isolation and fatty acid distribution.


Fatty acid metabolism in Drosophila melanogaster. II. Metabolic origin of monoenes.


Effect of fructose on rat lipids.

Effect of fructose on rat lipids.


The metabolism of linoleic and arachidonic acids in rat testis.


Liberation of aldehydes from alk-1-enyl glyceryl ethers by acid hydrolysis.


The effect of hydrogen peroxide on serum lecithin-cholesterol acytransferase activity.


The development of motor disturbances in experimental chronic carbon disulphide intoxication.


Surgical treatment of temporal lobe seizures.


Cysticercosis of the brain.

Cysticercosis of the brain.


Acoustic neurinoma.

Acoustic neurinoma.


Trigeminal neuralgia.

Trigeminal neuralgia.


Intraspinal dermoids.

Intraspinal dermoids.


Motor nerve conduction velocity in diabetic neuropathy.


Spinal extradural cryptococcal granuloma. A case report.


Thoracic intervertebral disc prolapse. (A case report with a five year follow-up).


Australia antigen--a glimmer of hope.

Australia antigen--a glimmer of hope.


Physician-patient relationship lacking.

Physician-patient relationship lacking.


Continuing medical education. II. AMA physician recognition award and other mistakes.


Tracheal stenosis: a disease of medical progress. Surgical repair of three cases.


Standards again demonstrated.

Standards again demonstrated.


Amebic abscess of the liver in Vietnam.

Amebic abscess of the liver in Vietnam.


Effect of reserpine on 22Na and 42K exchange in the cat papillary muscle.


Effects of spontaneous ischemia on aerobic metabolism of cortical and medullary homogenates of dog kidney.


Effect of H-1 virus infection on RNA synthesis in NB cells.


The influence of structural abnormality on ion transport in rabbit ileum.


Ionic flux across the gastric mucosa: effects of atropine on the permeability of fundus and antrum.


Permeability of superficial proximal tubules and loops of henle to urea in rats.


Effect of long-term hypoxia on protein synthesis in granuloma and in some organs in rats.


Enhanced hepatic protein synthesis in rats force-fed a tryptophan-devoid diet.


Effects of boranes upon tissues of the rat. II. Tissue amino acid content in rats on a normal diet.


Alterations in splenic hilar lymphatics in patients with congestion of the spleen.


Fractionation of rat liver chromatins: effects of cations, hepatectomy and actinomycin D.


Early tissue 65 Zn distribution after duodenal dosing in calves fed zinc-deficient and control diets.


Intestinal absorption of micellar lipid in normal and bile deficient rats.


Effects of chronic administration of sheep stalk-median eminence extract on organ weights of immature hypophysectomized rats with pituitary grafts.


Precipitation of soluble fibrin monomer complexes SFMC by cellular basic proteins, and the antagonistic effect of sulfonated mycopolysaccharides.


Significance of different routes of introduction on the transport of substances into the brain.


Impaired water metabolism in germfree rats.


Preparation of highly purified concentrates of Coxiella burneti.


Effect of administering 8-azaguanine at various times on liver enzyme activities of starved-refed rats.


Reduced lymphatic drainage from hamster cheek pouch.


Thiamine deficiency and experimental cardiac necrosis.


The binding of benz [a] anthracene to replicating and nonreplicating DNA in cell culture.


Antibody synthesis in vitro: the antigenic reactivity of antibodies to coliphage MS-2 synthesized in the presence and absence of streptomycin.


Arthritis and psoriasis: the effects of antipsoriatic agents in the adjuvant-induced arthritic rat.


The distribution of a particulate trypsin inhibitor in brain.


Effects of heat, diet and hormones on total body protein turnover rate in young and old rats.


Aminoaciduria in experimental lead poisoning.


Effect of steroids on serum sialic acid values in the canine.


Isolation and partial characterization of protein polysaccharides from rat costal cartilage.


Effect of low sugar intake upon blood lipids and insulin levels of hyperlipemic subjects.


Effects of some pharmacologic agents on gastric cation secretion: ratio of hydrogen to potassium ions.


Activation of trypsin by anti-inflammatory drugs.


Study on the mechanism of dopamine-induced inhibition of hemoglobin synthesis in chick blastoderm in vitro.


Effect of ethanol on the conjugation of benzoate and salicylate with glycine in man.


Reversal of antilymphocytic serum-induced immunosuppression by macrophage administration.


Removal of alpha-methyldopa (aldomet) in man by dialysis.


Depletion of ventricular catecholamine levels following peripulmonary neurectomy.


Adrenal function during long-term anesthesia in man.


Bone marrow blood flow after marrow removal or nutrient vessel ligation.


The influence of thymectomy and steroid hormones in neonatal rats.


Effect of estrogen on bone mineral  turnover in mature female rats as measured by strontium-85.


Cold hemagglutinin associated with leptospiral hemolytic anemia in the sheep.


Effect of insulin on creatinuria and hypercreatinemia induced by creatine loading.


Left and right ventricular pressures in the normal and the cardiomyopathic syrian hamster (Mesocricetus auratus).


Cross immunity among strains of Chlamydia psittaci.


The treatment of asthmatic children away from home.


Morbidity and mortality in children under 16 at the Provincial Hospital of Quang Ngai, South Vietnam, 1965-8.


Thrombopoietin activity in children with cyanotic congenital heart disease.


The concentration of granulocytic stem cells in mouse bone marrow, determined with diffusion chamber technique.


The effect of extended-field radiotherapy on peripheral blood values in advanced Hodgkin's disease.


Platelet survival in Hodgkin's disease.

Platelet survival in Hodgkin's disease.


Mitotic activity of circulating atypical lymphocytes.


Extraosseous plasmacytomas causing extrahepatic cholestasis and cardiac tamponade. A unique case of multiple myeloma.


Congenital deficiency of factor 13 in an Indian kindred.


Cytogenetic studies in myeloproliferative disorders during transformation into leukaemia.


51Cr-half life time of heavy and light human erythrocytes.


Influence of splenectomy on thymic release of lymphocytes into the blood.


Cytoplasmic microtubules and radial-segmented nuclei (Rieder cells). Effects of osmolality, ionic strength, pH, penetrating non-electrolytes, griseofulvin, and a podophylline derivative.


The interpretation of red cell survival curves in non-stationary states. I. The mean cell life span as calculated from the initial disappearance rate of labelled red cells.


Diagnosis and assessment of bleeding tendency in chronic liver failure using three simple coagulation tests.


The presence of non-recirculating long-lived lymphocytes in rat blood.


A possible new variant of G-6-PD with decreased activity (G-6-PD-Utrecht) in a Dutch family with hereditary spherocytosis.


The haematological response to androgens in sickle cell anaemia.


Effect of treatment with combined phenformin and ethyloestrenol on the coagulation and fibrinolytic systems.


Communication disorders and the quest for relatedness in families of schizophrenics.


Psychoanalysis and religion.

Psychoanalysis and religion.


Religion, mental health and the psychoanalyst.


Self-consciousness considered within a theory of self.


Spatiality--a concern of the psychoanalyst.


Emotional hazards of plolice work.

Emotional hazards of plolice work.


Mythic consonance and dissonance in the vicissitudes of transference.


The simulation of psychosis: a contemporary presentation.


The effect of ECT on memory and learning.


Behavioural treatment of a homosexual with compulsive rituals.


Music therapy in the setting of a psychotherapeutic centre.


Distractibility in the mentally retarded: negative evidence for an orienting inadequacy.


A review of research: reading and the educable mentally handicapped.


Performance of cerebral palsied children under conditions of reduced auditory input.


Morphologic changes in the fetal rabbit kidney after intrauterine ureteral ligation.


Preparation of a pure glomerular fraction: a modification.


The effect of uremic environment on renal concentrating and diluting mechanisms in a severely damaged nephron population.


The effects of cholinergic and adrenergic drug stimulation of detrusor muscle.


Parameters of renal functional capacity in reversible hydroureteronephrosis in dogs. V. Effects of 7 to 10 days of ureteral constriction on RBF-Kr,C-In, Tc-H2O, C-PAH, osmolality, and sodium reabsorption.


Cortical blood flow in ureteral obstruction.


Transcutaneous measurement of the urethral lumen.


Experimental study of sites of lymph formation in the canine kidney.


Nishimoto-Takeuchi-Kudo disease: case report. The case is reported of a 7-year-old Czech boy with an obliterating disorder of the large intracranial arteries with formation of an extensive collateral network of blood vessels of the `rete mirabile' type. It is analogous to cases described under the names `abnormal cerebrovascular network', `occlusion of the circle of Willis', or the `moyamoya disease' by Japanese authors.


Effect of hypnotic susceptibility on creativity test performance.


Effects of modiiication of cognitive style on creative behavior.


Renal trauma.

Renal trauma.


Medical therapy of renal calculi.

Medical therapy of renal calculi.


Results of a long-term study of non-functioning tuberculous kidneys.


Lymphangiectasia simulating polycystic disease.


Pyelonephritis with vasculature suggesting renal cell carcinoma: case report.


Crossed, fused, renal ectopia with an ectopic ureterocele.


Human ureteral peristalsis.

Human ureteral peristalsis.


Factors which contribute to or prevent sloughing of the distal ureter: an experimenatal study.


Bilateral, synchronous, primary transitional cell carcinoma of the ureter: report of 2 cases add review of literature.


Further attempts at internal urinary diversion: an experimental study.


Bladder exstrophy.

Bladder exstrophy.


Inverted papilloma of the bladder.

Inverted papilloma of the bladder.


Treatment of delayed intractable hemorrhagic cystitis following radiation of chemotherapy.


Hamartoma of the bladder.

Hamartoma of the bladder.


Clinical staging of bladder tumors.

Clinical staging of bladder tumors.


Giant condyloma of the penis.

Giant condyloma of the penis.


Local anesthesia for acute epididymitis.


Induction of diuresis following transurethral resection of the prostate.


Experiences with F-32 in advanced carcinoma of the prostate.


A simple, inexpensive technique for photographing roentgenograms.


Urogenital sinus outlet obstruction.

Urogenital sinus outlet obstruction.


Local androgenic effect of interstitial cell tumor of the testis.


I-131 uptake by thyroid of hypophysectomized dogs with salivary gland transplants in the sella turcica.


Hemodynamic response to hypoxia in dogs with special reference to ventilation.


Survival comparison between totally hypophysectomized dogs and dogs with a transplant of salivary gland in the place of the extirpated hypophysis.


Self-stimulation enhancement in diabetic rats.


Metabolic activity of rat brain mitochondria during postnatal development.


Inhibitory properties of rat liver homogenate on glycogen synthesis.


The effect of prior diet upon glucose and glibenclamide pancreatic insulin response.


Metabolic changes during severe acute hypercapnia.


Subcellular distribution of acid phosphatase in the mouse testis.


Mitochondrial changes on ATP-treated choroid plexuses.


The information center and what it can do for you.


Vocal cord remobilization in the canine larynx.


Nasofrontal duct in frontal sinus fractures.


Physiology of the nasal valve.

Physiology of the nasal valve.


Skin-muscle flap for orbital floor fractures.


Polytef injection for nasal deformity.

Polytef injection for nasal deformity.


Anterior glottic stenosis. Experimental and clinical management.


Surgery of the crooked nose.

Surgery of the crooked nose.


Lateral osteotomy drainage tubes in rhinoplasty.


Middle ear ventilation in chronic otitis media.


Eustachian tubal function. Changes in anatomy and function with age and the relationship of these changes to aural pathology.


Irradiation as an etiologic factor in the development of melanoma.


Herpes zoster oticus.

Herpes zoster oticus.


Selection for constancy of expression of the Tabby gene in the mouse.


Development of the epidermis of the marsupial Trichosurus vulpecula.


Metabolic fate of parenterally administered sulphur-containing amino acids in sheep and effects on growth and composition of wool.


Uterine endometrial phosphomonoesterases in relation to implantation in the ewe and rabbit doe.


Pathogenic variation in Ophiobolus graminis.


Prophylactic and therapeutic vaccination against ovine foot-rot.


Field observations on four outbreaks of maternal dystocia in the Merino ewe.


Isolation of Leptospira hardjo from cows with mastitis.


The efficiency of Australian Newcastle disease virus for vaccine production.


Hyperglycaemia in acute malathion poisoning in fowls.


A method for investigating the effects of drugs on the exploratory behaviour of mice. 1. Exploratory behaviour in mice was observed when they were put on a wooden board to which twelve tunnels were fixed. The number of different tunnels entered (indicating exploration) and the total entries into tunnels were recorded over 5 min on 2 successive days.2. Untreated mice entered more different tunnels in the first minute on the second day on the tunnel board, and this difference in behaviour was taken as an indication that exploration had occurred on the first day. When the behaviour of the treated mice on the second day was similar to that of inexperienced mice on the first day it was inferred that drug treatment had adversely affected exploration.3. Haloperidol 4 mg/kg, chlorpromazine 8 mg/kg and thioridazine 16 mg/kg adversely affected exploration at doses which almost immobilized the mice.4. Amphetamine at 8 mg/kg disrupted exploratory behaviour in the mice, although the mice were observed to move round the board very quickly.5. With tranylcypromine 2 mg and nialamide 100 mg, increased exploratory behaviour by comparison with controls was recorded in the mice when they were tested 24 h after drug treatment.6. Imipramine at 20 mg/kg reduced the total number of tunnels entered by the mice on the first day, but on the second day the mice behaved in a similar way to mice treated with monoamine oxidase inhibitors.


Quantitative studies of the effect of antagonists on the acute toxicity of organophosphates in rats. 1. The subcutaneous acute toxicities of the vinyl phosphate pesticides monocrotophos, dicrotophos, chlorfenvinphos, crotoxyphos, dichlorvos, mevinphos, and of the experimental compounds SD 4455 (cis-2-carboxy-1-methylvinyl dimethylphosphate) and SD 7779 (cis-2-(1-phenylethoxy) carbonyl-1-methylvinyl diethylphosphate) have been determined in female rats.2. The effects on the log dose-probit mortality curves to the vinylphosphates of the therapeutic subcutaneous administration of methylatropine, atropine, N-methylpyridinium-2-aldoxime methanesulphonate and obidoxime have been studied.3. Elevation of the LD50 values by the therapeutic regimens was shown to be an unsatisfactory measure of therapeutic efficiency, while reduction of the effect of a maximally lethal dose (LD90) to less than that of a minimally lethal dose (LD10) provided a better quantitative measure of therapeutic efficiency.4. The combination of atropine sulphate (50 mumol base/kg) with obidoxime (250 mumol/kg) was found to be generally the most effective of the antidotal regimens.


Inhibition of brain cholinesterase activity after the injection of organophosphorus compounds in the rat.


The pharmacological effects of ouabain administered intracerebrally to conscious mice.


Some effects of muscarine on the central nervous system of chickens.


Some effects of nicotine on the central nervous system of chickens.


The effect of adrenaline on 5-hydroxyindole concentrations in the hypothalamus and thalamus of rat.


A comparison of the analgesia produced by morphine and the sympathomimetic drugs.


Acute toxicity of heroin, alone and in combination with cocaine or quinine.


The effect of propranolol on the human and canine transmembrane action potential.


Binding sites for 2-haloalkylamines.

Binding sites for 2-haloalkylamines.


Comparative effectiveness of lignocaine, quinidine, propranolol and procainamide as antifibrillatory agents.


The uptake of adrenergic neurone blocking drugs.


Raspberry leaf tea: a new aspect to an old problem.


The Schultz-Dale reaction in bovine pulmonary smooth muscles.


Effects of azathioprine and phenylbutazone in rat adjuvant arthritis.


The origin of ascorbic acid stored in the leucocytes.


The growth maintaining activity and intestinal absorption of ascorbic acid in guinea-pigs.


The concentration of catecholamines in the brain of the domestic fowl (Gallus domesticus). 1. The concentrations of adrenaline and noradrenaline in the brains of chickens (Gallus domesticus) have been determined using two different methods of fluorimetric analysis.2. The concentrations of adrenaline, noradrenaline and also dopamine were found to increase with age, as did the relative amount of adrenaline present in the chicken brain.3. It was observed that the differential assay of adrenaline by the trihydroxyindole method often underestimated the amount of adrenaline present.


Liver damage and excretion of bivalent sulphur after exposure to carbon disulphide in fed and fasted rats with and without phenobarbitone pretreatment.


Central effects of picrotoxin when acting from the liquor spaces in anaesthetized cats. 1. Picrotoxin was perfused through different parts of the cerebral ventricles in cats anaesthetized with chloralose, and applied topically to the upper cervical cord in cats anaesthetized with intraperitoneal pentobarbitone sodium. With both methods, picrotoxin produced effects similar to those produced by tubocurarine; but it was active in weaker concentrations.2. Perfused through the third ventricle, picrotoxin caused shivering resulting in a rise of rectal temperature, increased motor excitability, muscle jerks, tachypnoea, mydriasis, and withdrawal of the nictitating membranes. The effects were due to an action on structures in the walls of the ventral half of the ventricle, because they occurred only on perfusion of tubocurarine through this half and not on its perfusion through the dorsal half of the third ventricle. Noradrenaline perfused through the third ventricle abolished the shivering and the rise in temperature, but did not affect the motor hyperexcitability or the muscle jerks, whereas pentobarbitone sodium similarly perfused abolished these effects as well.3. Perfused through the inferior horn of a lateral ventricle, picrotoxin caused excitation of the hippocampus. This resulted in a rhythmic discharge of high voltage negative spikes in the electrocorticogram taken from the occipital cortices. The spikes developed after-positivity with after-discharges and were interrupted from time to time by bursts of fast activity termed episodes. This abnormal discharge was recorded also from the perfusion cannula which was inserted into the inferior horn and acted as a lead from the surface of the hippocampus.4. Perfused through the anterior horn of a lateral ventricle picrotoxin caused a rhythmic discharge of negative spikes which was recorded from the anterior horn cannula and resulted from excitation of the grey matter in the anterior limbic area which forms part of the medial wall of the horn.5. Applied to the surface of the upper cervical cord, picrotoxin produced scratching movements.


The effect of Arvin on reticuloendothelial activity in rabbits. 1. Arvin stimulated the reticulo-endothelial uptake of colloidal carbon in rabbits. The onset of effect after intravenous administration was immediate and the minimum stimulant dose by this route was very low-0.05 unit/kg (0.1 mug protein/kg).2. Carbon opsonized in vitro with serum taken 4 h after an intravenous injection of Arvin was cleared more rapidly than carbon treated with control serum. Serum collected 10 min after Arvin did not promote carbon uptake.3. Reticulo-endothelial block with Thorotrast or excess carbon did not prevent the stimulant effect of Arvin but prevented the stimulant effect of opsonization with 4 h serum.4. The reticulo-endothelial stimulant effect of Arvin appears to be unrelated to its coagulant action on fibrinogen. The mechanism may involve a direct action on phagocytic cells and an effect on colloidal particles via serum opsonins.


Actions of some cholinergic antagonists on fast-twitch and slow-twitch skeletal muscle of the cat. 1. The anticholinergic drug N-ethyl-2-pyrrolidylmethylcyclopentylphenyl glycollate (PMCG) has been studied for its effects on the contraction of fast-twitch (flexor hallucis longus, FHL) and slow-twitch (soleus) muscles in the cat.2. In both muscles lower doses (0.25 to 10 mg intra-arterially) potentiated and higher doses (10 mg and above) depressed twitches produced by indirect stimulation. Similar effects were obtained in directly stimulated muscles.3. The effects of the drug on muscles stimulated repetitively were dependent on both dose and frequency of stimulation. Doses which potentiated twitches also potentiated low frequency tetani (5-30 Hz for soleus; 10-50 Hz for FHL). There was a depression and non-maintenance of higher frequency tetani (80 Hz and above for soleus; 150 Hz and above for FHL).4. Both atropine and caramiphen had similar dose dependent potentiating and depressant actions. Hyoscine acted similarly in some cats; in others it had only a depressant action.5. It is suggested that the potentiating actions of PMCG, caramiphen, atropine and hyoscine are due to a direct musculotropic action. The depressant actions resulting from higher doses are due, in part, to a curare-like action and in part to a direct action on the muscle fibres.


Actions of sarin on fast-twitch and slow-twitch skeletal muscles of the cat and protective action by anticholinergic drugs. 1. The organophosphate cholinesterase inhibitor sarin has been studied for its effects on the contraction of fast-twitch (flexor hallucis longus, FHL) and slow-twitch (soleus) muscles in the cat.2. In both muscles lower doses (2.5 to 20 mug intra-arterially) potentiated, and higher doses (20 mug and over) depressed, twitches produced by indirect stimulation. Muscle action potentials became repetitive. There was no simple relationship between degree of inhibition of blood cholinesterase and effect on muscle twitch.3. The effects of the drug on repetitively stimulated muscles were dependent on both dose and frequency of stimulation. Doses of 2.5 to 10 mug increased the degree of fusion of low frequency tetani (10 Hz for FHL, 5 Hz for soleus) but depressed and caused non-maintenance of tetani at high frequencies (150 Hz and above for FHL, 60 Hz and above for soleus). Doses of 20 mug and above depressed and caused non-maintenance of tetani at all frequencies.4. The anticholinergic drug N-ethyl-2-pyrrolidylmethylcyclopentylphenyl glycollate (PMCG) injected intra-arterially protected both muscles from the effects of sarin on twitch but less so from effects on tetani. When given after sarin the drug reversed twitch potentiation and repetitive firing. In contrast, atropine had little effect on the responses to sarin.5. The effects of (+)-tubocurarine were compared with those of PMCG.6. The possible mode of action of PMCG is discussed.


Microinjections of tubocurarine, leptazol, strychnine and picrotoxin into the cerebral cortex of anaesthetized cats. 1. In cats anaesthetized with intravenous chloralose, microinjections of tubocurarine, leptazol, strychnine or picrotoxin, in a volume of 1 mul, were made into the grey matter of the cerebral cortex and the electrical activity was recorded from the site of injection with the microinjection cannula which, insulated except at its tip, served as recording electrode.2. Routinely the injections were made into the gyrus splenialis or into the underlying gyrus cinguli close to the mid-line, because the injections would then most likely be in grey and not in white matter. Injected in this way all four drugs set up foci of excitation which gave rise to synchronous firing of a large number of neurones with the result that high voltage negative spikes were recorded from the microinjection cannula.3. On injection into the gyrus splenialis the threshold dose was about 0.04 mug for picrotoxin, about 0.2 mug for tubocurarine, about 5 mug for strychnine and 25 to 50 mug for leptazol. Following the injection of larger doses the spike discharge continued for a few hours after picrotoxin and tubocurarine, for over an hour after strychnine, but for a few minutes only after leptazol. On injection into the gyrus cinguli the threshold doses were slightly greater and with larger doses the spikes occurred at greater frequency but were of lower voltage than in the gyrus splenialis.4. With large doses of picrotoxin injected into the gyrus splenialis the spikes developed an after-positivity and an after-discharge which sometimes passed into a short period of fast activity.5. The foci of excitation set up by the drugs were restricted to the site of injection because on raising or lowering the microinjection cannula the spikes recorded from it quickly decreased in voltage and then disappeared. When the injections were made close to a sulcus and the microinjection cannula, on being lowered, traversed the sulcus, the spikes changed their polarity.6. The spike discharge appears to be a consistent response to the injections of the drugs into grey matter of any part of the cerebral cortex since it was also obtained on their injection into the pyriform cortex, amygdala and area retrolimbica anterior, but not on their injection into white matter or caudate nucleus, thalamus or hypothalamus.


The effects of caerulein on insulin secretion in anaesthetized dogs. 1. Insulin concentration changes in pancreatico-duodenal venous plasma were studied in anaesthetized dogs injected with caerulein.2. Rises in insulin concentration were elicited by rapid intravenous injection of caerulein, as well as by intravenous infusion. Threshold doses were 10 ng/kg and 0.5-1 (ng/kg)/min respectively.3. At the highest dose used (500 ng/kg by rapid intravenous injection and (25 ng/kg)/min by intravenous infusion) the increase in immuno-reactive insulin release was approximately 7 to 9 times the base levels.4. Adrenalectomy potentiated the effects of intravenous infusion of caerulein.5. On a molar basis, caerulein was 2-3 times as active as pancreozymin.6. It is concluded that caerulein is a potent stimulant of pancreatic islets in the dog and that it may be considered as a model peptide, capable of being substituted for pancreozymin in any experiment.7. The mechanism of the insulin stimulating effect of caerulein is discussed. The possibility of a direct "beta-cytotropic" effect of the peptide is suggested.


Pathology and prognosis of carcinoma of the stomach.