Lactate, ATP, and CP in working muscles during exhaustive exercise in man.


Effect of muscular activity on bile acid excretion in rats.


Increased atelectatic pulmonary shunt during hemorrhagic shock in dogs.


Reduction of reactive hyperemia in the human forearm by face immersion.


Peak measured velocity of shortening in the canine left ventricle.


In vivo visualization of small-airway constriction after pulmonary microembolism in cats and dogs.


Oxygen debt after submaximal physical exercise.


Role of air temperature and wind in the time necessary for a finger to freeze.


Autologous pulmonary embolism in the intact, unanesthetized dog.


Effects of heating and cooling of the spinal cord on preoptic unit activity.


Effects of water intake on composition of thermal sweat in normal human volunteers.


Mobilization of energy sources in exercising dogs.


Vertical gradient of transpulmonary pressure with active and artificial lung expansion.


Brain temperature and cutaneous blood flow in the anesthetized pig.


Determination of valvular pressure gradients by visual comparison of areas.


An indirect method for determination of tissue: blood partition coefficient for xenon 133.


Polyvinyl alcohol--- heparin hydrogel "G".


Design of a small-animal pneumotachograph.


Apparatus measuring oxygen consumption and expired CO2 and 14CO2 in small subjects.


A method for measurement of dynamic compliance of the left ventricle in dogs.


Variable-temperature nerve chamber.

Variable-temperature nerve chamber.


An electrooptical monitoring technique for heart cells in tissue culture.


Theory of the globe thermometer.

Theory of the globe thermometer.


A simple reliable membrane oxygenator for organ perfusion.


Lipids of Rhizopus arrhizus Fischer.

Lipids of Rhizopus arrhizus Fischer. The lipids of Rhizopus arrhizus Fischer mycelia and sporangiospores were extracted, isolated, and separated by thin-layer, liquid, and gas chromatography. Structural confirmations of the compounds were made by a gas chromatographmass spectrometer combination. The n-heptane fraction contained squalene (1%) as a major hydrocarbon constituent. Other major lipid classes detected were free fatty acids, naturally occurring methyl esters of fatty acids, triglycerides, sterols, and polar lipids. The polar lipids (44.4%) were found in the highest concentrations, and the triglycerides (22.1%), sterols (16.7%), and free fatty acids (11.7%) were present in lesser concentrations. This is the first report of naturally occuring methyl esters of long-chain fatty acids being present in fungal mycelium. There appears to be a preference for incorporation of unsaturated acids into the complex lipids, with the exception of the triglycerides. The major saturated fatty acids in the mycelium were palmitic (C(16)) and arachidic (C(20)), whereas the major unsaturated acids were oleic (C(18:1)) and linoleic (C(18:2)), respectively.


Intracellular substrates for endogenous metabolism during long-term starvation of rod and spherical cells of Arthrobacter crystallopoietes. Cells of Arthrobacter crystallopoietes, harvested during growth as spheres and as rods, were starved by shaking at 30 C in phosphate buffer for 30 days, during which time they maintained 100% viability. Changes in cellular components and the activity of specific enzyme pathways were monitored. A glycogen-like polysaccharide comprised 40% of the dry weight of growing spherical cells and 10% of the dry weight of rod cells. This material was utilized at approximately the same rate, on a percentage basis, during starvation of both cell forms. The rods degraded intracellular protein at approximately twice the rate of the spheres. At the end of 30 days, the rods had degraded 40% and the spheres 20% of their initial content of protein. Ribonucleic acid (RNA) was degraded significantly more rapidly in the rods. After 30 days starvation, 85 and 32% of the initial RNA of rods and spheres, respectively, had been depleted. Magnesium ion followed this same general pattern; the rods lost 65% and the spheres 45% of their initial content during 28 days of starvation. Deoxyribonucleic acid increased by 20% during the first few hours of starvation of both cell forms and then remained constant. The ability of glucose-, succinate-, and 2-hydroxypyridine (2-HP)-grown cells to oxidize glucose remained constant during 14 days of starvation. The ability of succinate-grown cells to oxidize succinate decreased rapidly during the first few hours of starvation to a rate which remained constant for 14 days. Cells adapted to growth on 2-HP completely lost their ability to oxidize this substrate after 3 days starvation.


Feedback inhibition of L-glutamine D-fructose 6-phosphate amidotransferase by uridine diphosphate N-acetylglucosamine in Neurospora crassa. The enzyme, l-glutamine d-fructose 6-phosphate amidotransferase (EC 2.6.1.16) of Neurospora crassa, which catalyzes the formation of glucosamine 6-phosphate was shown to be subject to feedback inhibition by uridine diphosphate N-acetyl-d-glucosamine (UDP-GlcNAc). The conclusion is based on the following observations. UDP-GlcNAc, the direct precursor of chitin, did not accumulate in the cell even when its utilization for the synthesis of cell wall chitin was interrupted by the antibiotic polyoxin D, a competitive inhibitor of the chitin synthetase (EC 2.4.1.16). Furthermore, the cellular level of UDP-GlcNAc rose in a short period of time when the amidotransferase was bypassed in vivo by the addition of glucosamine to the growing medium of the fungus. The amidotransferase was purified from N. crassa approximately 85-fold. Kinetic studies showed that UDP-GlcNAc was a potent and specific inhibitor of the amidotransferase, and that it did not alter the Michaelis constant for either l-glutamine or d-fructose 6-phosphate, suggesting that the inhibitor binds at a site on the enzyme distinct from the active site.


Similarities in the action patterns of exopolygalacturonate lyase and pectinesterase from Clostridium multifermentans. Exopolygalacturonate lyase and pectinesterase from Clostridium multifermentans were assayed simultaneously in the same reaction mixture which contained a highly esterified pectin, polymethyl polygalacturonic acid methyl glycoside. Lyase is specific for unesterified galacturonide residues and cannot degrade this substrate in the absence of the esterase. The rate for esterase was twice the rate for lyase throughout the entire course of the combined reaction. Thus, the molar ratio of the two enzyme activities was the same since the product of the lyase is an unsaturated digalacturonic acid containing two free carboxyl groups. Since clostridial exopolygalacturonate lyase is known to degrade polygalacturonate in a linear manner beginning from the reducing ends of polygalacturonate chains, it was apparent that clostridial pectinesterase must hydrolyze methyl groups in highly esterified pectins with an action pattern similar to that of the lyase. Otherwise it would be impossible for the two enzyme rates to have corresponded on the basis of a 2:1 ratio.


Differential depression of staphylococcal plasmid and chromosomal penicillinase genes by a class of unlinked chromosomal mutations (R2-). We described previously a class of mutations (phenotypic designation R2(-)) in Staphylococcus aureus that were unlinked to penicillinase genes but nevertheless imposed constitutive synthesis of this enzyme upon wild-type plasmids. The plasmids affected by these mutations have been found to possess the same maintenance-compatibility type (I) and to form penicillinase of serotype A. Three plasmids that had a different maintenance-compatibility type (II) and formed penicillinase of serotype C were only slightly derepressed in R2(-) mutants. Three chromosomal penicillinase genes were variably derepressed, the range extending from negligible to nearly complete derepression. The differences in degree of derepression among the three types of penicillinase linkage groups were tentatively ascribed to position effects.


Inhibition of carotenoid hydroxylation in Staphylococcus aureus by mixed-function oxidase inhibitors. Compounds known to be inhibitors of mixed-function oxidase systems inhibited the aerobic synthesis of hydroxylated carotenoids in Staphylococcus aureus U-71. Growth of the cells in the presence of 2-diethylaminoethyl-2,2-diphenyl valerate, 2,4-dichloro-6-phenylphenoxyethylamine, 2,4-dichloro-6-phenylphenoxyethyldiethylamine, and piperonyl butoxide reduced the levels of the rubixanthins found in stationary-phase cells by 75 to 97%. In cells grown with mevalonate-2-(14)C, the turnover rate of phytoene was reduced and the turnover rate of phytofluenol was increased in the presence of these inhibitors. The zeta- and delta-carotenes, which turn over in the absence of the inhibitors, accumulated (14)C in the presence of the inhibitors. This suggested that a mixed-function oxidase was responsible for the aerobic hydroxylation of delta-carotene in S. aureus U-71.


Tryptophan transport in Neurospora crassa: a tryptophan-binding protein released by cold osmotic shock. Osmotic shock treatment of germinated conidia of Neurospora reduced the capacity for tryptophan transport in these cells approximately 90% without an appreciable loss of cell viability. Tryptophan-binding proteins and alkaline phosphatase were consistently released into the osmotic shock fluid by this treatment. Four lines of evidence suggest that the binding protein may be related to the tryptophan transport system. (i) It appears to be located on or near the cell surface. (ii) a decreased capacity for binding tryptophan was observed in shock fluids from cells repressed for tryptophan uptake; reduced or altered binding capacity was released from a transport-negative mutant. (iii) The specificity of tryptophan binding was similar to that observed in the in vivo transport system. (iv) The dissociation constant for binding, as measured by equilibrium dialysis, was approximately the same as the K(m) for tryptophan transport.


Galactose transport in Saccharomyces cerevisiae. II. Characteristics of galactose uptake and exchange in galactokinaseless cells. The characteristics of the inducible galactose system in Saccharomyces cerevisiae were studied by using the nonmetabolized galactose analogues, l-arabinose and d-fucose, and galactokinaseless and transportless mutants. Induced wild-type cells transport l-arabinose by facilitated diffusion. Transportless cells transport neither galactose nor l-arabinose above the noninduced rate, whereas galactokinaseless cells transport galactose l-arabinose and d-fucose by facilitated diffusion. Determination of unidirectional rate of (14)C-labeled galactose uptake by preloaded galactokinaseless cells, containing a large unlabeled free-galactose pool, showed that the rate of galactose uptake by facilitated diffusion is greater than the rate of galactose metabolism at similar external galactose concentrations.


Galactose transport in Saccharomyces cerevisiae. 3. Characteristics of galactose uptake in transferaseless cells: evidence against transport-associated phosphorylation. The characteristics of the inducible galactose transport system in bakers' yeast were studied in uridine diphosphate, galactose-1-phosphate uridylyl-transferaseless cells. Transferaseless cells transport galactose at the same initial rate as wild-type cells and accumulate a mixture of free galactose and galactose-1-phosphate. The addition of (14)C-labeled galactose to cells preloaded with unlabeled galactose and galactose-1-phosphate results in a higher rate of labeling of the free-sugar pool than of the galactose-1-phosphate pool. These results support other evidence that galactose uptake in bakers' yeast is a carrier-mediated, facilitated diffusion and that phosphorylation is an intracellular event after uptake of the free sugar.


Role of thiosulfate in bisulfite reduction as catalyzed by Desulfovibrio vulgaris. Studies with (35)S-labeled substrates were conducted to investigate the pathway involved in the reduction of sulfite to sulfide by cell-free extracts of the sulfate-reducing organism Desulfovibrio vulgaris. The results showed that accumulation of thiosulfate occurred when crude extracts were incubated under appropriate conditions with sulfite as substrate. With labeled sulfite as substrate, thiosulfate with equal distribution of radioactivity in both sulfur atoms was formed. When the rates of formation of (35)S(2-) from inner- and outer-labeled thiosulfate were compared, the rate of formation from outer-labeled thiosulfate was greater. Time studies with S-(35)SO(3) (2-) showed an increase of (35)S(2-) with time and an increasing ratio of doubly labeled to inner labeled thiosulfate remaining in the reaction mixture. From these studies it is concluded that thiosulfate is a stable intermediate formed from sulfite during the reduction of sulfate by D. vulgaris. Both sulfur atoms are derived from sulfite; during the utilization of thiosulfate, the outer sulfur is reduced to sulfide and the inner sulfur recycles through a sulfite pool.


Photoinhibition of growth in Acanthamoeba castellanii cultures. Light from 350 to 680 nm at intensities up to 1.62 x 10(5) ergs per sec per cm(2) slowed exponential growth and lowered the maximum yield in axenic cultures of Acanthamoeba castellanii. Photoinhibition was a linear function of light intensity up to 1.25 x 10(5) ergs per sec per cm(2). At higher intensities, growth was too slow to be measured accurately. A photochemical change occurring in the growth medium on irradiation was a function of light dosage and not intensity per se. Light in dosages which appreciably changed the growth-supporting properties of the medium exceeded the dosages received by exponentially growing cultures during irradiation. Consequently, photoinhibition of growth was attributed to a direct effect of light on the amoebae, not to photodegradation of the medium. The growth-supporting properties of irradiated media could be restored by the addition of yeast extract and Proteose peptone. The reduced growth rate in the light was not due to cyst formation or induction of multinuclearity. Light affected the amoebae either through absorption by intracellular pigment(s) or through binding to the amoebae of a photosensitizing compound in the medium.


Gene mutation eliminating antimycin A-tolerant electron transport in Ustilago maydis. A class of mutants of Ustilago maydis selected on a fungitoxic oxathiin lack of antimycin A-tolerant respiratory system which is present in wild-type cells. This system provides, directly or indirectly, for considerable resistance to antimycin A because growth of mutant cells lacking the system is much more sensitive to the antibiotic than that of the wild type. Antimycin A-sensitive O(2) uptake and growth is found in half of the progeny from crosses of mutant to wild type. All antimycin A-sensitive segregants are somewhat more resistant to oxathiins than the antimycin A-resistant segregants. The respiration of the mutant is strongly inhibited by cyanide and azide at concentrations which stimulate respiration of the wild type. Respiration of both mutant and wild type is about equally inhibited by rotenone. It appears that the mutation alters some component of the respiratory system located between the rotenone inhibition site and the antimycin A inhibition site that permits shift of electron transport to an alternate terminal oxidase when the normal electron transport pathway is blocked.


Extracellular cell wall lytic enzyme from Staphylococcus aureus: purification and partial characterization. An autolysin obtained from culture fluid of Staphylococcus aureus strain 8507 was purified 3,000-fold. One milligram of this preparation (S-5DL) will solubilize 12 mg of cell wall in 1 hr. The major activity is N-acetylmuramyl-l-alanine amidase. Recovery of lytic activity in the purified preparation was repeatably only 20% of the starting level. This suggests that other cell wall lytic enzymes may be present in the starting material. The S-5DL enzyme has been compared to freeze-thaw extracted enzyme (AFZ). Both enzymes precipitate in 0.01 m KPO(4) (pH 6.0) and dissolve in 0.1 to 0.7 m NaCl. Fifty per cent of the AFZ activity and 66% of the S-5DL activity bind rapidly to cell walls of S. aureus at 0 C in the presence of magnesium ion. None of the AFZ activity and 66% of the S-5DL activity bind to cell walls at 0 C in the absence of magnesium ion. The cell walls of nine different strains of S. aureus were compared for level of native autolysin activity. These same walls after inactivation of the native autolysin were tested for susceptibility to the S-5DL enzyme.


Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. IV. Evidence for a general amino acid permease. Kinetic and genetic evidences are presented to show that, in addition to specific amino acid permeases, Saccharomyces cerevisiae has a general amino acid permease which catalyzes the transport of basic and neutral amino acids, but most probably not that of proline. The general amino acid permease appears to be constitutive, and its activity is inhibited when ammonium ions are added to the culture medium. A mutant which has lost the general amino acid permease activity was isolated. Its mutation, named gap (general amino acid permease), is not allelic to the aap (amino acid permease) mutation of Surdin et al., which has a quite different phenotype and cannot be considered as having selectively lost the general amino acid permease activity.


Evidence for genetic interaction between plasmid and chromosomal penicillinase linkage groups in Staphylococcus aureus. Spontaneous reciprocal recombination was detected between the regulator genes of penicillinase plasmids and chromosomal penicillinase linkage groups of Staphylococcus aureus. The frequency of recombination varied with different penicillinase linkage groups.


Thermally induced intracellular alteration of ribosomal ribonucleic acid. Heating at 55 C causes the intracellular degradation of ribosomes of Staphylococcus aureus MF-31. The 30S subunit of heated cells appears to be selectively attacked. Analysis of ribonucleic acid (RNA) showed that 16S RNA was destroyed and that the secondary structure of 23S RNA was altered.


Assay of cocaine in the presence of procaine and quinine by column chromatography.


Characterization of phosphonomycin by microchromatographic and related techniques.


Gas-liquid chromatography of caramiphen hydrochloride and its analogues.


Buffer preservative failure and modification of in-line buffer filter for automated step-change amino acid analyzers.


A simple technique for the estimation of mitochondrial glutamate-oxaloacetate transaminase in serum and tissues.


Polyacrylamide gel electrophoresis and gel filtration of dyed polysaccharides.


Separation and detection of synthetic sweetners by thin-layer chromatography.


The separation of the ultraviolet-absorbing constituents of urine by high-pressure liquid chromatography.


Chromatography of biogenic amine metabolites and related compounds on lipophilic sephadex. II. The catecholamines and their 3-O-methylated derivatives.


Mobile coronary care units. A preliminary critique.


Use of general duty ambulances as mobile coronary care units.


An approach to the identification of high risk individuals in the general population.


Functional prognosis of the hemiplegic.

Functional prognosis of the hemiplegic.


Seminole medicine.

Seminole medicine.


Automation in the practice of medicine.

Automation in the practice of medicine.


Politics and medicine.

Politics and medicine.


Slaves and prophets.

Slaves and prophets.


Valuing the environment.

Valuing the environment.


Experimental production of transients in human interaction.


Theory for the mechanism of chloroquine resistance in rodent malaria.


Prebiotic synthesis of polypeptides by heterogeneous polycondensation of amino-acid adenylates.


Proton magnetic resonance studies at 220 MHz of the histidine residues of staphylococcal nuclease.


Absolute stereochemistry of the second step of ribonuclease action.


Strontium-90 and infant mortality in Canada.


In vivo cortisol action on RNA synthesis in rat liver nuclei and mitochondria.


In vitro production of nucleolar channel system by progesterone in human endometrium.


Interaction of atropine with the muscarinic receptor.


Doubtful value of bicuculline as a specific antagonist of GABA.


Bicuculline and central GABA receptors.

Bicuculline and central GABA receptors.


Extremely small motions of the basilar membrane in the inner ear.


Demonstration of intention in the reaching behaviour of neonate humans.


Further evidence for reduced role of photorespiration in low compensation point species.


Nature of acquired resistance to filarial infection in albino rats.


Palace and pollution.

Palace and pollution.


Sex--and the 24 hours.

Sex--and the 24 hours.


Nursing care of babies with cleft lip and palate. 1. The Pierre Robin syndrome.


Twelve months' attachment: from the local authority.


Airport nurse.

Airport nurse.


Mental illness and the district nurse. 3. Preventive measures.


The lonely adolescent.

The lonely adolescent.


The complete family planning service at King's College Hospital.


The widow's mite.

The widow's mite.


Nursing in transition in Mauritius.

Nursing in transition in Mauritius.


A changing night administration.

A changing night administration.


How not to obtain student nurses.

How not to obtain student nurses.


Children in a district hospital ITU.

Children in a district hospital ITU.


'Don't sacrifice the children to the nurses'.


Computer in the ward.

Computer in the ward.


Nursing care of babies with cleft-lip and palate. 2. Pre-surgical correction of the deformed maxillary arch.


Chronic renal failure: a patient care study.


Practice makes perfect?

Practice makes perfect?


Some simple get-you-home tricks.

Some simple get-you-home tricks.


The dignity of labour.

The dignity of labour.


Nursing auxiliaries.

Nursing auxiliaries.


The problem of asbestos.

The problem of asbestos.


Case closed--wound open.

Case closed--wound open.


Bedsores--the missing links?

Bedsores--the missing links?


Putting a lid on it. Suppression of gastric reflux.


The British Army in Amman.

The British Army in Amman.


On being an agency nurse.

On being an agency nurse.


Why paediatric nurses? 1. An assessment of the past, present and future of this nursing specialty.


Angled bilateral cervical arteriography in the investigation of ischemia.


Change and advancement for radiologic technologists: the importance of being earnest.


Problems in socioeconomics for radiologic technologists: panel discussion.


Technique for radiographic localization of non-palpable breast tumors.


Survey results of the use of x rays in the healing arts specialties in North Dakota, 1964-1968.


President's message.

President's message.


Washington dateline.

Washington dateline.


Criteria of brain death.

Criteria of brain death.


Amino acid synthesis in stimulated primitive environments.


DDT ban: a judgment of emotion and mystique.


International research: its role in environmental biology. To determine the role of environmental factors in human health, studies on several population groups are essential, involving the most sophisticated techniques possible. The logistic and political problems associated with such studies, especially in developing countries, and the high cost of modern environmental biological investigations make it particularly desirable to avoid unnecessary duplication and waste of resources. For certain investigations an international research center would appear to have considerable advantages, provided that the organizational difficulties can be overcome. Not only can such an organization provide the human data necessary for calculating the balance between the benefits and harm of a given course of action but also it may stimulate the long-term routine laboratory studies so necessary as a basis for extrapolation from animals to man.


The organization of language and the brain.


Synthesis of amino acids by the heating of formaldehyde and ammonia. The heating of formaldehyde and ammonia yields a product that, on hydrolysis, is converted into seven amino acids: aspartic acid, glutamic acid, serine, proline, valine, glycine, and alanine. Glycine is the predominant amino acid. Inasmuch as formaldehyde and ammonia have been identified as compounds in galactic clouds, these experimental results are interpreted in a cosmochemical and geochemical context.


Centrifugal effects in the avian retina. Electrical stimulation of the centrifugal fibers to the avian retina can disturb the balance between the excitatory and inhibitory system within the receptive fields of individual retinal ganglion cells. Although the mechanisms may vary from one unit to another, the effect is always to make them fire more readily and to a wider range of visual inputs.


Recent mortality trends for emphysema and other chronic respiratory diseases.


Catastrophic death toll lower in first half of 1970.


Accidental injuries--disability by type.


American longevity in 1968.

American longevity in 1968.


Further observations on upper urinary tract smooth muscle. A light and electron microscope study.


Response of host embryonic chicks to grafts of additional adrenal glands. II. Ultrastructure of normal and host adrenal glands.


The arrangement of neurosecretory and catecholamine fibres in relation to the pituitary intermedia cells of the skate, Raja radiata.


Association of glial cells with the terminal parts of neurite bundles extending from chick spinal cord in vitro.


Alterations of platelet aggregaion in the Chandler tube. I. Turbidimetric studies.


Aggregation of human blood platelets and its correlation with their uptake of phospholipid-specific dyes.


Aids to electronic platelet counting.

Aids to electronic platelet counting.


A modification of the erythrocyte osmotic fragility test.


Fatal primary amebic meningoencephalitis. A retrospective study in Richmond, Virginia.


Laboratory suggestions. Electrophoresis of unconcentrated cerebrospinal fluid on agarose using the Spectrophor I.


Letters to the editor. Identification of Serratia organisms.


Multitest screening and ninety-five per cent limits.


Experimental infection of the argasid tick, Ornithodoros moubata porcinus, with African swine fever virus.


Significance of microbial interactions in control of microbial ecosystems.


Preparation and characterization of isolubilized L-amino acid oxidase.


The relationship of oxidation-reduction potential to the growth performance of tissue culture media poised prior to incubation.


Oxidation-reduction potential and concomitant growth patterns of cultures of Earle's "L" cells in centrifuge bottle spinners.


Glucose and lactic acid trends in suspension cultures of two established mammalian cell strains in chemically defined media.


Blood glucose levels and food intake in the domestic chicken.


Oxidation of L-hydroxyproline in the liver and kidney of the rat and domestic fowl in vitro.


Specific inhibition of morphogenesis in Trichinella spiralis by insect juvenile hormone mimics.


Changes in the distribution of Hymenolepis diminuta (Cestoda: Cyclophyllidea) within the rat intestine during prepatent development.


Distribution of long-chain fatty acids among the lipid classes of Lucilia sericata (Meigen) and Galleria mellonella (Linnaeus).


Fine structure of the impulse-conducting system in rat heart.


Alkaline phosphatase activity and histogenesis in two species of urodele amphibians.


Response of host embryonic chicks to grafts of additional adrenal glands. I. Response of host adrenal glands, gonads, and kidneys.


The ontogenesis of cortical circuitry: the spatial distribution of synapses in somesthetic cortex of newborn dog.


Experimental frostbite. The effect of hyperbaric oxygenation on tissue survival.


Silastic oxygenator and perfusion system for canine liver and kidney preservation.


Freeze-drying various attenuated strains of Pasteurella pestis.


An apparatus for regulating the freezing and thawing rates in the cryopreservation of blood cells.


The critical thermal minimum of small rodents in hypothermia.


Cryobiology of platelets. II. Effects of freezing and storage at low temperatures on the survival of isolated human blood platelets as measured by assays for aminopeptidases.


Cryoprotective additives and hypertonic hemolysis.


A comparison of lethal procedures by cesium-137 assay.


Inhibition of Candida utilis by cycloheximide and acetoxycycloheximdie.


Synthesis of macromolecules in the yeast Candida utilis as influenced by a specific factor inducing cell division.


Antimicrobial agents. VI. Antimycotic activity and problems of resistance.


The relative specificity of mutagens for the induction of forward mutations in Corynebacterium.


Pancreatic function and intestinal absorption in chronic alcoholism.


Comparison of dose-response relations of insulin and 2-deoxy-D-glucose for biliary and gastric acid secretion in dogs.


Studies on human gastric gel mucin. Isolation and characterization of a major glycoprotein component.


Effect of bile salts on ionic movement across the human gastric mucosa.


Comparison of dose-response curves with subcutaneous and intravenous histamine.


The effect of graded insulin doses on incompletely vagotomized subjects.


The effect of bile on electrolyte movement across canine gastric antral and fundic mucosa.


Inhibitory effects of a purified enterogasterone, secretin, and cholecystokinin on histamine-stimulated gastric acid secretion.


Duodenal ulcer as a second disease.

Duodenal ulcer as a second disease.


Pacemaker localization and electrical conduction patterns in the canine stomach.


Action of caerulein on gastric secretion in man.


Effects of drugs, ileal obstruction, and irradiation on rat gastrointestinal propulsion.


Pressure inversion point at the upper high pressure zone and its genesis.


Magnesium absorption by everted sacs of rat intestine and colon.


Hyperplastic mucosal changes in the rabbit colon produced by degraded carrageenin.


Jaundice associated with peritoneal absorption of bilirubin.


Cultivating the source.

Cultivating the source.


Photodecomposition of bilirubin.

Photodecomposition of bilirubin.


The relationship between age and sodium metabolism in human erythrocytes.


Decrease of creatine-phosphate restitution of muscle in old age and the influence of glucose.


The threshold theory of ageing.

The threshold theory of ageing.


The need for therapeutic and administrative partnerships.


Public information in community mental health.


Photography enhances mental health information.


Psychiatric nurses as consultants in a general hospital.


Authority: its nature and use in the therapeutic relationship.


A rehabilitation team on a State hospital unit.


Should purchasing approve invoices?

Should purchasing approve invoices?


An historical analysis of the viability of for-profit hospitals.


How much for Sisters' maintenance?

How much for Sisters' maintenance?


The labor law status of health care facilities. 3. Proprietary hospitals, nursing homes, and state and federal government hospitals.


Medical staff functions and leadership.

Medical staff functions and leadership.


The hospital medical director: an administrator's view.


Management education.

Management education.


Hospital design and infection control.

Hospital design and infection control.


Playroom in the outpatient clinic.

Playroom in the outpatient clinic.


Medical staff appointments.

Medical staff appointments.


Automated screening systems.

Automated screening systems.


Hospital social work programs.

Hospital social work programs.


Orientation and training.

Orientation and training.


Diabetic patients require education and understanding.


Measuring job satisfaction.

Measuring job satisfaction.


Clinical pharmacy: general hospital.

Clinical pharmacy: general hospital.


Basics of biologic relativity.

Basics of biologic relativity.


Biometric studies of army conscripts in Greece. Mean stature and ABO blood-group distribution.


Physique and the eosinophil count.

Physique and the eosinophil count.


Comparative study of body composition of American and Filipino women.


Body weight at birth of viable human infants: a worldwide comparative treatise.


Sex ratio of Guyanese of African and East Indian origin.


Physical anthropology of the Negroes of Charleston, S. C.


Effect of ecological and socio-economic factors on the age at menarche, body height and weight of rural girls in Poland.


Growth and development of the Bundi child of the New Guinea highlands.


Age of menarche of a group of Singapore girls.


Hematologic changes to 4 and one-half years of age in clinically normal beagles.


Toxicity of disophenol at excessive dosages in newly weaned pups.


Anesthesia for parakeets and other birds.


Observations on the use of glyceryl guaiacolate in the horse.


Sphenociadium capitellatum (whiteheads) toxicosis of cattle and horses.


Pharmacologic diagnosis of Horner's Syndrome in the dog.


Physiological effects of parathion on the cockroach gut in vivo and correlation with external symptoms of poisoning.


Induction by DDT and dieldrin of insecticide metabolism by house fly enzymes.


Residues of ethylene dibromide, methyl bromide, and ethylene chlorobromide resulting from fumigation of fruits and vegetables infested with fruit flies.


Residues of Rabon in tissues and egg yolks of poultry.


Fate of carbofuran in laying hens.

Fate of carbofuran in laying hens.


Insect repellency of N,N-diethyl-m-toluamidine--a nitrogen isostere of Deet.


Mosquito control agents derived from petroleum hydrocarbons. IV. Further larval abnormalities produced by FLIT MLO.


Mosquito-repellent dihydroxyacetone monoesters.


Residues of aldrin, dieldrin, chlordane, and DDT in soil and sugarbeets.


Ovicidal effect of selected compounds on the eggs of Anopheles albimanus.


Studies on control of house flies in Egypt by chemosterilants. 3. Sterilization of Musca sorbens by apholate, tepa, and hempa.


Studies on the control of mosquitoes in Egypt by means of chemosterilants. 3. Sterilization of Anopheles pharoensis and Culex pipiens by Metepa.


Susceptibility of adult Hippelates pusio to insecticidal fogs.


Susceptibilities of adult Hippelates eye gnats to insecticidal deposits.


Skin repellents against Aedes aegypti.

Skin repellents against Aedes aegypti.


Insecticide resistance and cross-resistance in Aedes nigromaculis.


Small-scale field tests with dermally applied animal systemic insecticides for control of the common cattle grub.


Systemic insecticide study on livestock in California, 1965-67. 1. Cattle grub control.


Detection of residues of Rabon in manure of Rhode Island red hens.


Seven juvenile hormone analogues as synergists for pyrethrins against house flies.


Effect of monoamine oxidase inhibitors on carbaryl metabolism.


Similarly I will not--cause abortion.

Similarly I will not--cause abortion. The writer opposes abortion in all cases, including rape, except to save the mother's life.  "Liberalized" abortion laws place nonmedical responsibilities on doctors.  Physicians should return to the Hippocratic Oath, which emphasizes their responsibilities to the community, their patients, and their profession.  The Oath stresses the independent judgment of the doctor.


Angiography of pheochromocytomas in children.


Presacral extension of carcinoma of the cervix.


The need for an increase in AMA dues.

The need for an increase in AMA dues.


Should blood sales require sales tax?

Should blood sales require sales tax?


Impedance plethysmography: a noninvasive means of monitoring the thoracic surgery patient.


The technical details of bronchial brushing.


Effect of oxygen and helium mixtures on ventricular fibrillation.


Evaluation of dextrose, insulin, and potassium on ventricular irritability in acute myocardial infarction.


Replacement of the aortic valve with molded autogenous grafts grown in response to implanted Silastic.


Deterioration of formalin-treated aortic valve heterografts.


Myocardial metabolism in acute regional eschemia.


Mapping of epicardial and intramural activation of the heart: a technique for localization of chronic infarction during myocardial revascularization.


Operative assessment of ventricular aneurysm and adynamic myocardium.


A comparison of lung scanning and differential bronchospirometry as pulmonary function tests in dogs.


Left ventricular function after occlusion of the ascending aorta: assessments of various methods for myocardial protection.


Mediastinoscopy--good or evil?

Mediastinoscopy--good or evil?


Experimental aspergillosis in mice. II. Enhanced susceptibility of the cortisone treated mice to infection with Aspergillus fumigatus, Aspergillus flavus und Aspergillus niger.


Some data on the treatment of otomycoses.


Endemic trichophytosis in Brazilian pemphigus patients.


Post-mortem mycological investigation of 100 cancerous patients.


Tinea pedis--a clinical and mycological study.


Determination of individual tropa-alkaloids in Belladonnae herba, Belladonnae radix and extractum belladonnae.


Evaluation of the Schirmer Tear Test.

Evaluation of the Schirmer Tear Test.


Arteriography, pelvic pneumography and lymphangiography augmenting assessment and staging of carcinoma of the cervix.


Anal lesions of granulomatous (Crohn's) disease of the bowel.


Performance and reliability of cholecystography.


Diagnosis and management of vertical strabismus.


Nasal papillomatosis.

Nasal papillomatosis.


Metacarpophalangeal and interphalangeal joint reconstruction: use of silicone rubber-dacron prostheses for replacement of irreparable joints of the hand.


Perianal condyloma.

Perianal condyloma.


Emotional aspects of disability.

Emotional aspects of disability.


Medical Grand Rounds from the University of Alabama Medical Center.


Retrosternal dislocation of the clavicle.


Familial leukemia: a report of 4 cases of acute leukemia in 4 consecutive generations.


Primary hyperparathyroidism at the Ochsner Clinic: experience with 100 cases.


Experimental total body hypothermia: a comparison of three methods of production.


Therapeutic orphans: who speaks for children?


The nutritive effect in man of non-essential amino acids infused intravenously (together with the essential ones). I. Individual non-essential amino acids.


The oxygen tension of cerebrospinal fluid in patients with brain lesions.


The effect of mepivacaine and lidocaine on forearm resistance and capacitance vessels in man.


Heart-rate changes after atropine and neostigmine given for the reversion of muscle paralysis.


Mast cells in endosteal and periosteal bone repair. A quantitative study on callus tissue of healing fractures in rabbits.


Healing in the experimentally fractured os priapi of the rat.


Diagnostic use of 85 strontium in the preoperative evaluation of non-union.


Recurrent dislocation of the shoulder treated by transposition of the tendon to pectoralis minor. A follow-up of fifteen patients.


Vertebral angiosarcoma. A case report.

Vertebral angiosarcoma. A case report.


Roentgen appearance of coxarthrosis. Relation between the anatomy, pathologic changes, and roentgen appearance.


[Traumatic dislocations of the hip. Follow-up on cases from the Stockholm area].


Growth disturbances of the proximal end of the femur. An animal experimental study with tetracycline.


Resection of the metatarsophalangeal joints in rheumatoid arthritis.


The effect of dinitrophenol on secretory potentials, secretion and potassium accumulation in the perfused cat submandibular gland.


Variation in total body water with muscle glycogen changes in man.


Exchange of glucose between plasma, brain extracellular fluid and cerebral ventricles in cats and effects of intraventricular acetazolamide and insulin.


Adrenergic excitatory influences on initiation and conduction of electrical activity in the rat portal vein.


The effect of anesthetics on the tissue lactate, pyruvate, phosphocreatine, ATP and AMP concentrations, and on intracellular pH' in the rat brain.


Blood flow and oxygen extraction in the cat uvea at normal and high intraocular pressures.


Thermogenesis of brown adipose tissue reflected in mitochondrial respiratory control.


Determination of cortical blood flow in rabbit femur by radioactive microspheres.


Effects of feeding states on lipid radioactivity in liver, muscle and adipose tissue after injection of labelled glucose in the rat.


The incorporation of cholesterol into the nervous system of the newly hatched chick.


Blood flow through limb muscles during heavy rhythmic exercise.


Distribution of choline acetyltransferase in the hearts of mammals.


Time relations of degeneration mydriasis and degeneration vasoconstriction in the rabbit ear after sympathetic denervation. Effect of bretylium.


Background of increased flow resistance and vascular reactivity in spontaneously hypertensive rats.


Effect of hypotonic mannitol and saline load on diluting capacity in man.


Mechanisms involved in the cat's blink reflex.


Renal reabsorption and metabolic conversion of galactose in the cat.


Potentiation by various smooth muscle stimulants of an isolated sympathetic nerve-seminal vesicle preparation from the guinea-pig.


Single unit analysis of mechanoreceptor activity from the human glabrous skin.


Projections to the cerebral cortex from afferents of the interosseous nerves of the cat.


Effects of increased liver metabolism of nicotine on its uptake, elimination and toxicity in mice.


The effect of anesthetics upon labile phosphates and upon extra- and intracellular lactate, pyruvate and bicarbonate concentrations in the rat brain.


Acetylation of p-aminohippuric acid in the kidney. Renal clearance of p-aminohippuric acid and N4-acetylated p-aminohippuric acid in pigs.


Ontogenesis of peripheral adrenergic neurons in the rat: pre- and postnatal observations.


The circadian fluctuations of the amount of free phosphate and of the activity of acid phosphatase in the kidneys of mice and the effect of UV radiation upon this rhythm.


Carcinoma of the larynx. I. Treatment mainly by primary irradiation.


Radiopathology of americium 241. I. Distribution of americium in adult mice.


Concentration of zinc in some hard and soft tissues of rat determined by neutron activation analysis.


Roentgen ray effects on the ovaries of foetal mice.


Early effects of localized single doses of ionizing radiation on human bone marrow.


Depigmentation of hair in two strains of mice after single and fractionated doses of roentgen rays.


Dose response of jejunal sucrase and maltase activities to isocaloric high and low carbohydrate diets in man.


Nutritional macrocytic anemia of infancy and childhood.


Effect of pyridoxine supplementation on glutamic-pyruvic transaminase and in vitro stimulation in erythrocytes of normal women.


Nutrition as a national priority. Lessons from the India experiment.


The Caribbean food and nutrition institute.


Nutritional rehabilitation centers in Latin America: a critical assessment.


Symposium on food science and nutritional diseases in the Middle East.


Intestinal microflora. Introduction.

Intestinal microflora. Introduction.


Introduction to the ecology of the intestinal flora.


Human normal and abnormal gastrointestinal flora.


Ecologic consequences of resistance--transfer factors.


Enteric pathogen--normal flora interactions.


Human fecal flora under controlled diet intake.


Associations of indigenous microorganisms with gastrointestinal mucosal epithelia.


Metazoa-protozoa-bacteria interrelationships.


Metabolic contributions of the cecal flora.


Effect of hibernation on the intestinal flora.


Oil-mist studies, environmental evaluation and control.


Hydrazine toxicity in pregnant rats.

Hydrazine toxicity in pregnant rats.


An epidemiologic study of an oil mist exposure.


Serum proteins and kidney function after exposure to cadmium.


In vivo and in vitro ciliotoxic effects of tobacco smoke.


Effects of environment on respiratory function. 3. Weekly studies on young male adults.


Commission on chronic illness follow-up study. Comparison of screened and nonscreened individuals.


A hypothesis regarding the pathophysiology of acute mountain sickness.


Absenteeism and "presenteeism" in industry.


Evaluation of safety for food additives: An illustration involving the influence of methyl salicylate on rat reproduction.


Validation of an in vitro enzyme assay indirectly measuring an in vivo biosynthesis.


Use of graph theory in computation of inbreeding and kinship coefficients.


Effects of selection and drift on the dynamics of finite populations. II. Expected time to fixation or loss of an allele.


Selectively disadvantageous mutants.

Selectively disadvantageous mutants.


Drug interaction.

Drug interaction.


Change detection model for serially correlated multivariate data.


The effect of hyperventilation on the size and shape of alveoli.


Cardiovascular collapse following induction with propanidid.


Heart rate and arterial blood pressure during different forms of induction of anaesthesia in patients with mitral stenosis and constrictive pericarditis.


Sodium nitroprusside as a hypotensive agent in general anaesthesia.


Redox state of the liver during anaesthesia as studied by parenteral galactose loads in children.


Determination of the serum cholinesterase.


Clinical studies of induction agents. XXXVI: Ketamine.


Effect of magnesium on ventricular fibrillation due to hypothermia.


Unsteadiness after relaxant anaesthesia.


Propanidid alone for antral washout in adults.


Anaesthesia for profound selective autocerebral cooling and circulatory arrest of human brain. A case report.


Apparent death with accidental hypothermia. A case report.


A surgical hazard of central venous pressure monitoring. A case report.


Amino acid sequence around the active site aspartic acid in penicillopepsin.


Isolation and characterization of beta-lipolytic hormone from porcine pituitary gland.


Agents affecting lipid metabolism. XXXIX. Effect of combined administration of ethyl chlorophenoxyisobutyrate and cholestyramine on cholesterol biosynthesis in the rat.


Effect of organic reducing agents and ferrous ion on thioglucosidase activity of Crambe abyssinica seed.


L-cysteinylglycine: its occurrence and identification.


The effect of urea upon the activity measurement of cod muscle cathepsin with hemoglobin substrate.


Defective respiration and oxidative phosphorylation in muscle mitochondria of hamsters in the late stages of hereditary muscular dystrophy.


Quantitative estimation os bile salts in serum.


The interaction of alpha-chymotrypsin with phenylalanine derivatives containing a free alpha-amino group.


Hemoglobin Mahidol: a new hemoglobin alpha-chain mutant.


The effect of puromycin and aminonucleoside on kidney proteins.


The middle ultraviolet spectra of proteins. II. The denatured states of RNase.


The middle ultraviolet spectra of proteins. I. Studies on model compounds.


Soluble esterases of human lung.

Soluble esterases of human lung.


Detection of carbon. Phosphorus bonds by proton nuclear magnetic resonance spectroscopy.


Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts.


Cell killing and the accumulation of breaks in the DNA of HEp-2 cells incubated in the presence of hydroxyurea.


The golgi apparatus during mitosis in human melanoma cells in vitro.


Production of leukemia and stomach neoplasms in Swiss, RF, BALB-c, and C3H female mice by feeding N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide.


[Decreased hydroxylation of steroid hormones by liver microsomes from rats bearing Walker carcinosarcoma 256].


Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.


Acid hydrolase activity in the leukocytes of tumor-bearing rats.


Studies on the chemotherapy of experimental brain tumors: development of an experimental model.


Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-l-nitrosourea, cyclophosphamide, mithramycin, and methotrexate.


RNA synthesis in nuclei isolated from normal and Friend virus-infected mouse spleen.


Virus-like particles in chemically induced sarcomas in high- and low-leukemia strains of mice.


A review of the Culicoides nigrigenus group, with two new species (Diptera: Ceratopogonidae).


Detection of phosphohexose isomerase deficiency in human fibroblast cultures.


Gene frequencies of red cell adenosine deaminase, adenylate kinase, phosphoglucomutase, acid phosphatase and serum alpha-1-Antitrypsin (Pi) in a German population.


Contributions to the genetics of serum beta-lipoproteins in man. IV. Evidence for the existence of the Ag-a1-d and Ag-c-g loci, closely linked to the Ag-x-y locus.


Induction of DNA synthesis in human lymphocytes: interaction between non-specific mitogens and antigens.


Antibody responses of goldfish to bovine serum albumin. Primary and secondary responses.


Cell-mediated immune responses to heterologous and homologous thyroglobulin in guinea-pigs immunized with heterologous thyroid extracts.


Secretion of IgA in the sheep following local antigenic stimulation.


Early 7S antibody--antigen complexes with affinity to spleen cells in chickens immunized with a low dose of human serum albumin.


The rapid purification of peritoneal exudate macrophages by ficoll (polysucrose) density gradient centrifugation.


Examination and reevaluation of prosthetic lenses employing an operant procedure for measuring subjective visual acuity in a retarded child.


An appliance for autoinduced adverse control of self-injurious behavior.


Visual abilities and pattern preferences of premature infants and full-term neonates.


A survey of twin pregnancy.

A survey of twin pregnancy.


Obturator hernia. A report of three cases with strangulation occuring twice in two patients.


Total hip replacement--the past, present, and future.


Complications following abdominal surgery.


The induction of autologous immune-complex nephritis in neonatally thymectomised rats.


Hyperplasia of bronchial muscle in chronic bronchitis.


Storiform neurofibroma in the core of naevocellular naevi.


Histogenesis of intrapulmonary and endobronchial hamartomas and chondromas (cartilage-containing tumours): a hypothesis.


Reduction of 3,4-benzopyrene content in curing smoke by scrubbing.


Observations on the mechanically induced differentiation of cartilage from fibrous connective tissue.


Molybdate metabolism in Aspergillus nidulans. I. Mutations affecting nitrate reductase and-or xanthine dehydrogenase.


Px, a hybrid between the serologically unrelated and heteroimmune Salmonella bacteriophages P22 and Py. I. Some properties of Py and Px, genetic evidence for the hybrid nature of Px, and phenotypic mixing between P22, Py and Px.


Px, a hybrid between the serologically unrelated and heteroimmune Salmonella bacteriophages P22 and Py. II. Contribution of P22 genetic material to different Px variants.


Genetical analysis of glossy mutants of maize. 3. Intracistron recombination and high negative interference at the gl-1 locus.


The genetic analysis of regulation of amidase synthesis in Aspergillus nidulans. I. Mutants able to utilize acrylamide.


Infectious DNA from coliphage T1. II. Host-cell reactivation of UV-irradiated molecules.


Hyper-UV-sensitive yeast. I. Isolation and properties of two such mutants.


Physical properties of phage 299.

Physical properties of phage 299.


Continuing medical education. I. Surveys. Surveys.


Mutations of coliphage lambda affecting the expression of replicative functions O and P.


The physician and the pharmacist.

The physician and the pharmacist.


Is medical management of hyperparathyrodism ever justified?


Drug therapy. 8. Clinical application of the biologic half-life of drugs.


Renal carcinoma and arteriovenous fistula.


Notes on joint diseases. 8. Pseudogout.

Notes on joint diseases. 8. Pseudogout.


Acetylcholine, cholinesterase activity, and the aggregability of human platelets.


Plasma growth-hormone response to glucocorticoids in diabetics.


Influence of pregnancy and-or exercise on intestinal transport of amino acids in rats.


Effect of biogenic amines on the endocrine axis and esterase activity of hamster testes.


Fetal iron content following maternal achylia gastrica.


A rapid method for in vitro screening of immunosuppressants using mouse spleen cells.


The effect of rifampin on Toxoplasma gondii.


Inhibition of Walker 256 carcinosarcoma growth of dietary zinc deficiency.


Immunetolerance to experimental autoimmune nephrosis in rats.


Morphological aspects of the kinetically inactive human neutrophilic granulocytopoiesis.


Lipid composition of tissues from Electrophorus electricus.


Effect of chlorothiazide on renal blood flow in the conscious dog.


Influence of extracellular and intracellular factors on hippurate uptake by rat kidney cortex: acid-base effects.


Renal hypertrophy factor in serum of nephrectomized rats, with observations on species specificity.


The effect of route of administration and radiation on 3H-actinomycin D binding by mouse hepatocyte DNA.


Effects of toxicity and on enzyme activity of the interactions between aldrin, chlordane, piperonyl butoxide, and banol in rats.


Glucose metabolism by rat embryos in vitro.


Comparison of concomitant and sinecomitant tumor immunity.


The effect of malethamer on the excretion and plasma levels of sodium, potassium, and chloride.


Effect of starvation on pituitary and plasma growth hormone in rats.


Starch-fel electrophoresis of murine major urinary protein.


Glycosidases in canine pancreatic secretion.


The effect of diet protein on late burn mortality.


Vietnam: AAAS herbicide study.

Vietnam: AAAS herbicide study.


More mislabeling--more frustration.

More mislabeling--more frustration.


Mutagens and carcinogens.

Mutagens and carcinogens.


Neural events and the psychophysical law.


Interferon: clinical application of molecular biology.


Plasminogen: purification from human plasma by affinity chromatography. Plasminogen was prepared from human plasma by affinity chromatography on L-lysine-substituted Sepharose. Thirty milligrams of plasminogen, with a specific activity of 100 caseinolytic units (Committee on Thrombolytic Agents) per milligram of nitrogen, were obtained from 340 milliliters of plasma. This corresponds to over 200-fold purification from plasma. Disc-gel electrophoresis at pH 8.3 indicated seven distinct bands, all of which contained activity.


Mammoth hair: stability of alpha-keratin structure and constituent proteins. Hair from a woolly mammoth (Mammuthus primigenius, age about 32,000 years) retains the ordered structure characteristic of alpha-keratins, but the proteins of this hair differ in composition from and are smaller than similar proteins isolated from other keratins, for example, elephant hair. It is suggested that these changes have been caused by limited proteolysis.


Tolerance to morphine-induced increases in [14C]catecholamine synthesis in mouse brain. Morphine sulfate increased the incorporation of carbon-14-labeled tyrosine into labeled catecholamines in the mouse brain. Tolerance was manifested by a shift to the right in the dose-response curve for morphine after mice were treated repeatedly with morphine. Naloxone, a specific morphine antagonist, also shifted the dose-response curve for morphine to the right.


Neuraminidase activity in hela cells: effect of hydrocortisone. Homogenates of HeLa cells contain neuraminidase activity. This enzyme is particle-bound, and it has a pH optimum of 4.2. Hydrocortisone-regulated cells contain two to three times as much neuraminidase as the corresponding controls. The hydrocortisone treatment also causes an increase in the cell content of beta-glucuronidase and acid deoxyribonuclease.


A disease of goslings new to Britain.

A disease of goslings new to Britain.


Circadian rhythm of mitotic activity in the adult gull-tapeworm, Diphyllobothrium dendriticum (Cestoda).


The fine structure of the cysticercoid of Hymenolepis diminuta. I. The outer wall of the capsule.


Electron microscope studies of macrogametes and fertilization in Eimeria bovis.


Experimental secondary echinococcosis of Echinococcus granulosus. I. Development in different strains of mice.


Nutrition in the medical school.

Nutrition in the medical school.


Absorption of iron from chapatti made from wheat flour.


Changes in brain weight, cholesterol, phospholipid, and DNA content in marasmic children.


Composition of human nail substance.

Composition of human nail substance.


Patterns of growth and nutrition in childhood.


Use of semisynthetic fats in determining effects of specific dietary fatty acids on serum lipids in man.


Liver stores of alpha-tocopherol in a normal population dying suddenly and rapidly from unnatural causes in New York City.


Lipid absorption and lipid-reesterifying enzyme activity in small bowel of the protein-deficient rat.


Reactions of nutritionists to nutrient labeling of foods.


Dietary factors causing hypertension in India.


Prevalence and causes of anemia in children in Kiryat Shmoneh, Israel.


Nutrition teaching and research in Israel.


Evaporation-induced errors in clinical chemistry assays.


The clinical case study: a tool in medical technology education.


Preservation of urine sediments on slides.


The J. Burns Amberson Lecture--in defense of the lung.


Cigarette smoking among patients with respiratory disease.


Dynamic and static lung volumes, blood gas tensions, and diffusing capacity in patients with cystic fibrosis.


Intrapulmonary gas distribution. A comparison of the helium mixing time and nitrogen single breath test in normal and diseased subjects.


Measurement of the total lung capacity by helium dilution in a constant volume system.


Microwave transmission of chest roentgenograms.


Experimental papain-induced emphysema in dogs.


Acid-base equilibrium of cerebrospinal fluid in chronic respiratory acidosis and provoked hypercapnia in relaxed patients.


Systematic sarcoidosis with severe involvement of the upper respiratory tract.


Biosynthesis of a lipase by Mycobacterium smegmatis ATCC 607 infected by Mycobacteriophage D29.


The occurrence of lipids in Mycobacteriophage D29 propagated in Mycobacterium smegmatis ATCC 607.


Model for a pediatric respiratory disease center.


Adverse effects of isoniazid and their significance for chemoprophylaxis.


Heterotopic pancreatic tissue in the common bile duct or ampulla of Vater.


Improved extracorporeal hepatic assist using intermittent external pressure on the liver.


Hemopneumothorax following transabdominal vagotomy.


Atrophy of the right lobe of the liver: case report and review of the syndromes associated with atrophy or agenesis of the liver.


Fibroplastic response to intestinal carcinoid.


Alveolar hydatid disease with involvement of the inferior vena cava.


Leiomyosarcoma of the duodenum: report of two cases and review of the literature.


Acquired hourglass gallbladder.

Acquired hourglass gallbladder.


Splenic rupture masquerading as acute appendicitis.


Clinical significance of blood viscosity.


Concomitant hydroxyurea and radiotherapy in the preoperative management of locally advanced lung cancer.


Use of different sources of nitrogen in uremia.


Abnormalities of carbohydrate and lipid metabolism in uremia.


Disorders of red blood cell production in uremia.


The hemolytic uremic syndrome. Renal cortical thrombotic microangiopathy.


Uremic toxins and platelet function.

Uremic toxins and platelet function.


Uremic toxins.

Uremic toxins.


Permeability changes in experimental uremic encephalopathy.


Guanidinosuccinic acid in uremia.

Guanidinosuccinic acid in uremia.


Transketolase activity in uremia.

Transketolase activity in uremia.


Evaluation of amino acid and protein requirements in chronic uremia.


A humoral inhibitor of sodium transport in uremic serum. A potential toxin?


Uremia and insulin response.

Uremia and insulin response.


The effect of uremia upon glucose metabolism.


Uremic lipemia. An unrecognized abnormality in triglyceride production and removal.


Implications of dietary therapy.

Implications of dietary therapy.


A perspective on uremic toxins.

A perspective on uremic toxins.


Recovery after prolonged oliguria.

Recovery after prolonged oliguria.


Electroencephalogram changes secondary to asparaginase.


Passive length-tension relationship and hydroxyproline content of chronically denervated skeletal muscle.


Suture diastasis following rapid weight gain. Pseudopseudotumor cerebri.


Effects of facilitation exercise techniques in stroke rehabilitation.


The relationship of intermittent isometric exercise to fatigue of hand grip.


Surface electric stimulation of lower limb.


Value of polyphasic potentials in diagnosis of lumbar root lesions.


Clinical versus computer measurement of motor fiber conduction velocity in median nerve.


Studies on marsupial proteins. 3. N-bromosuccinimide cleavage of the alpha-chain of kangaroo haemoglobin and the amino acid sequence of the N-terminal fragment.


The absorption and metabolism of (14C)DDT in DDT-resistant and susceptible strains of the cattle tick Boophilus microplus.


Cooperative aspects of small ion, small molecule interactions with nucleic aicds. Potassium-polyriboadenylic acid, polyribouridylic acid. Ionic conductivity measurements vs. temperature were made on KCl solutions of K-polyriboadenylic acid + K-polyribouridylic acid (K-poly-A + K-poly-U) in regions of temperature and composition where the helix-coil transition occurred. It was possible to relate the measurements to a differential helix-to-coil binding of K(+) to nucleotide. The results were, within experimental error, the same as those obtained from a limited number of differential KCl activity coefficient measurements and from a theoretical interpretation of polymer free-boundary electrophoretic mobilities. It was concluded that the alkali ion-phosphate interaction in polynucleotides must be regarded as cooperative in nature and several criteria for recognition of such phenomena were given. A brief outline for a proposed statistical mechanical model for binding was presented.


The role of diffusion in bimolecular solution kinetics. An appropriate boundary condition is derived which permits both the bimolecular association and dissociation steps to be simultaneously treated within the framework of the theory of Smoluchowski, Debye, and Collins, and Kimball. Kinetic theory expressions are derived for the intrinsic rate constants. The transient case of the suddenly switched-on reaction is considered as well as the suddenly perturbed equilibrium, but only the time dependence of the rate constants is obtained. The frequency response spectrum for a diffusion-controlled reaction is obtained in the linear approximation and compared with the corresponding Debye relaxation spectrum.


The role of diffusion in enzyme kinetics. A discussion is given of the general role of diffusion in enzyme kinetics based upon a rigorous theory for bimolecular association and dissociation steps that was presented previously, and criteria are formulated for the dependence of the over-all rate on medium viscosity. With these criteria it is possible to conclude that a number of enzymes will exhibit no appreciable dependence of over-all rate on the medium viscosity, quite irrespective of the as yet unmeasured rate constants for association and dissociation of enzyme and substrate. The effect of adsorbing the enzyme onto the surface of a much larger spherical colloidal particle is considered with the conclusion that the rate will either remain the same or decrease, and that its sensitivity to medium viscosity will remain the same or increase.


Studies of electric capacitance of membranes. I. A model membrane composed of a filter paper and a lipid analogue. A hydrophobic filter paper of a given pore size containing a synthetic lipid, i.e. dioleyl phosphate, was interposed between aqueous electrolyte solutions having the same chemical composition and temperature. The electric capacitance and conductance of the membrane immersed in various concentrations of KCl were measured in the frequency range from 20 to 3 x 10(6) cycle/sec. The observed capacitance and conductance were found to be strongly dependent on the applied frequency. A theory is proposed to account for this dispersion of impedance observed in the present membrane-electrolyte system. The dispersion is attributed to the formation of bilayer membranes of the lipid inside the filter paper. The effects of the salt concentration, the adsorbed quantity of the lipid, and the pore size of the filter paper on the capacitance and conductance of the membrane are discussed in terms of the distribution function of bilayers formed within the filter paper.


On the transmission of information through sensory neurons. Information about muscle length is transmitted to the cerebellum from muscle spindle receptors through the dorsal spinocerebellar tract (DSCT). The "transinformation" about muscle length in single DSCT fibers was calculated from steady-state spike trains by two different methods, assuming that the decoding mechanisms use a frequency code. By the first method, the number of distinguishable muscle lengths (and thus the transiformation) was determined from the rate of convergence of the mean frequency of firing (with increasing number of intervals). The observation time necessary to estimate the mean frequency of the impulse train with a certain accuracy was independent of the stretch level, even though the number of intervals necessary to make this estimate was different at high and low levels of stretch. By the second method an input frequency-output frequency matrix was calculated. The transinformations and the rate of transinformation was then calculated from this matrix. There was an acceptable agreement in the estimates of transinformation by the two methods. The rates of transinformation are significantly increased by the particular time structure of the discharge patterns of the nerve cells. Consequently, the loss of information due to the synaptic coupling is appreciably reduced.


A pseudo-Markov model for series of neuronal spike events. Spike trains of spontaneous neuronal activity in the rabbit brain are submitted to statistical analyses based on the following pseudo-Markov model. The nerve cell is supposed to alternate between a bursting and a resting state. The numbers of consecutive spikes within each state are assumed to be independent integer-valued random variables with discrete probability distributions. Given the state, the interspike intervals are independent real-valued random variables. The two state semi-Markov model is obtained as a special case when the discrete distributions are geometrical. Statistical second-order properties of recorded spike trains are compared with those predicted by the model on the basis of known first-order properties. For that purpose, serial correlation coefficients and intensity functions for spike trains produced by the model are computed. A comparison between observed and predicted results for the spontaneous activity of 17 brain cells yields a good fit in eight cells and discloses some salient features of the statistical structure in the activity of six other cells. By making it feasible to compute theoretical correlograms, the model may advance the understanding of empirical correlograms. The possibilities for integrating this statistical model of spike trains with a model of the mechanism of spike train production are discussed.


The small angle light scattering of biological cells. Theoretical considerations. The light scattered by living biological cells (assumed homogeneous spheres with a relative refractive index, m = 1.05) at small angles has been calculated by the Hodkinson approximation and the more rigorous Mie theory. Both methods predict that relative volume distributions may be estimated from low angle scattering measurements on each cell in a population. Under conditions of short wavelength illumination or strong absorption, absolute volume information may also be obtained.


The effects of betel-nut chewing on the buccal mucosa of 296 Indians and Malays in West Malaysia. A clinical study. Changes in the buccal mucosa of 296 Indian and Malay betel-nut chewers in Perak, West Malaysia, were studied clinically. 167 out of 212 Indian subjects incorporated tobacco in their quids, while 45 out of 84 Malay subjects incorporated. "Gambir". The Indians appeared to show a higher proportion of mucosal changes, particularly when tobacco was used. "Gambir" did not appear to be potent in the production of mucosal changes. Comparison with studies in other parts of the world suggested comparable findings with respect to both tobacco and non-tobacco chewing samples, and there would appear to be some evidence that tobacco-containing quids are likely to produce a higher proportion of mucosal changes as compared to non-tobacco-containing quids. An attempt to demonstrate a dose-effect relationship by dividing the subjects into "slight" and "heavy" chewers did not yield significant differences between these two categories in each of the groups.


The effects of betel-nut chewing on the buccal mucosa: a histological study. Sixty-two "leukoplakias" from the cheeks of betel-nut chewers in West Malaysia were studied histologically. Ten biopsies were from non-tobacco betel-nut chewers. An amorphous von Kossa positive layer was seen on the keratin surface in 42 specimens. Tobacco did not appear essential for its formation, and it appeared to be significantly associated with parakeratosis. Its possible significance as a cuticle-like layer prolonging contact between carcinogens and the mucosa is discussed.Parakeratosis appeared to be the most common form of cornification seen, and the mitotic activity in parakeratinized leukoplakias appeared to be significantly greater than orthokeratinized leukoplakias.Comparison with studies on other population samples using different quids suggested that severe histological changes were more likely to be seen when tobacoo-containing quids were chewed as compared to non-tobacco-containing quids.An attempt to correlate the histological changes seen with the clinical habit in leukoplakias from chewers using tobacco-containing quids suggested that epithelial atrophy appeared to be significantly related to the duration of the habit but not to the "intensity" of the habit.


Antibody-producing capacity in human cancer. The antibody response to primary immunization with monomeric flagellin from Salmonella adelaide was studied in 61 patients with cancer and antibody-producing capacity was correlated with survival. In 27 patients suffering from "active" cancer, antibody-producing capacity was significantly depressed (P<0.05) as compared with sick but not cancerous controls; in 13 such patients who survived more than 6 months after immunization, antibody-producing capacity was moderately depressed, whereas in 14 who survived less than 6 months, the capacity was markedly depressed. In 34 patients with "cured" cancer, by surgery and/or radiotherapy, antibody-producing capacity was significantly greater than that of the "hospital" controls and patients with "active" cancer, but yet was significantly less than that of healthy subjects. Three explanations for the findings were considered: an immunodepressive effect of general debility, an immunodepressive effect specific to cancer and, on the other hand, the occurrence of cancer preferentially in individuals with an impaired capacity for antibody production. The present findings gained added relevance from recent evidence that a specific humoral immune response is evoked by antigens of certain types at least of human cancer.


Kaposi sarcoma of lymph nodes.

Kaposi sarcoma of lymph nodes. Sixteen out of 48 adult African patients with Kaposi sarcoma were found to have tumour tissue in lymph nodes. The evidence suggests that there are probably two main types of involvement. One occurs predominantly in younger patients and involves many groups of glands, probably develops in situ, and is associated with a poor prognosis. The other form is the result of metastasis to a node from an aggressive tumour in the neighbourhood. This occurs more commonly in the older patient and carries a much better prognosis than in those with generalised lymphadenopathy, though worse than in patients with nodular disease without gland involvement. Follow-up over a period of many years will be required to discover the outcome in these cases. Kaposi sarcoma is unusual in women but when it occurs runs a more aggressive course than in men.


Chromosomal DNA replication pattern in human tumour cells in vitro. The present paper deals with the chromosomal DNA replication pattern in human solid tumour cells in vitro. This was studied at the terminal stages of the S-period. All the cell lines of female origin showed a late replicating chromosome in group XX6-12. In cell lines of male origin one of the chromosomes of group 21-22Y was later replicating than the rest of the members of the group. The DNA replication pattern of the autosomes and the sex chromosomes was similar to that of the cultured human leucocytes. The results of the present study show that the DNA replication pattern of the chromosome in neoplastic cells is basically unchanged despite the changes in the chromosome number and morphology. Therefore the abnormal behaviour of the neoplastic cells cannot be related to the changes in the pattern of the chromosomal DNA replication.


The influence of thyroactive substances on the induction of cervico-vaginal tumours in intact and castrate rats. The effect of the administration of L-thyroxine and of methylthiouracil alone, together, in combination with stilboestrol or in the perinatal period on the induction of cervico-vaginal tumours by weekly local applications of DMBA was investigated in intact and castrate rats and compared with carcinogenesis in animals not additionally treated.In intact rats the rate of sarcoma induction is accelerated by methylthiouracil, delayed and reduced by methylthiouracil plus L-thyroxine and delayed by perinatal injection of either L-thyroxine or methylthiouracil. In castrates sarcoma induction is accelerated and increased by L-thyroxine, methylthiouracil and by combination of either substance with stilboestrol; it is accelerated but not significantly increased by combined treatment with the thyroactive compounds.The incidence of epithelial neoplasms is accelerated and increased in intacts and in castrates by methylthiouracil. This effect is slightly reduced in intacts but potentiated in castrates by additional stilboestrol treatment as well as by administration of L-thyroxine plus methylthiouracil.The incidence of sarcomas is significantly greater in intact than in spayed rats not additionally treated, greater in castrates than in intacts given L-thyroxine ± stilboestrol and not significantly different in intacts and castrates with any of the other additional medications. For epithelial tumours the incidence is low and similar in both groups without additional treatment, greater in spayed than intact animals given methylthiouracil plus stilboestrol or plus L-thyroxine.The influence of the thyroactive compounds on the induction of epithelial and sarcomatous tumours is not correlated with their effect on gain in body weight nor on growth of the stroma and of the epithelium of the vagina, cervix and uterus. Changes induced in the thyroid gland and the hypophysis are not correlated with those on carcinogenesis.Central and local factors may account for the differential response in carcinogenesis of intacts and castrates as well as of the epithelial and connective tissue of the cervico-vaginal tract to medication with thyroactive compounds.


The effect of multiple tumours on mammary tumour growth rates in the C3H mouse. Spontaneous and transplanted tumour growth rates studied in the C3H mouse have shown that when only one spontaneous tumour was present in one strain then the distribution of growth rates closely resembled that for first generation isotransplants of another strain. It was also shown that the number of spontaneous tumours (in the range one to four tumours) present on the mouse affected the tumour growth rate, i.e. the more tumours per mouse, the slower the growth rate of the earliest tumour. This factor might partly account for the discrepancy between human tumour growth rates (normally determined when many tumours are present in the patients) and the faster tumour growth rates observed in experimental animals, in which normally only single tumours are present.


Mammary tumour development in BR6 mice: ovarian influences and 5-hydroxytryptamine. Pregnancy-dependent mammary tumours in BR6 mice first appeared during the third week of pregnancy. Regressed tumours reappeared chiefly during the second week. Alkaline Phosphatase activity in normal mammary tissue indicated a uniform increase in growth during pregnancy with no marked increase at any particular time. Pseudopregnancy was not sufficient to induce new tumours, though it had some stimulating effect on existing, regressed ones. 5-Hydroxy-tryptamine did not cause tumours in virgin mice, but seemed to influence tumour appearance in breeding females. Its possible mode of action is discussed.


The acid soluble disulphide and mixed disulphide levels of some normal tissues and transplanted tumours. The acid soluble disulphides and mixed disulphides of a range of normal rat and mouse tissues and a number of transplanted rat or mouse tumours were measured. The result were considered in relation to other workers' data. It is noted that more radioresponsive tissues have higher levels than the more radioresistant tissues.


Lymphatic pressures and the flow of lymph.


The pattern of lacrimal injuries in naso-ethmoid fractures.


The restrictive pharyngeal flap.

The restrictive pharyngeal flap.


A case of epignathus with long term survival.


Histological changes following the surgical closure of a canine cleft palate.


Synovectomy of proximal interphalangeal joints.


W-plastic glabellar rhytidectomy.

W-plastic glabellar rhytidectomy.


Technique for preservation of the temporal branches of the facial nerve during face-lift operations.


Positive infusion control in the treatment of burns in children.


A quick-release connecting rod for cranio-mandibular fixation.


The plain chest radiograph in congenital heart disease.


Angiography in peripheral ischaemia due to ergotism. Report of two cases.


Femoral catheter techniques in cerebral angiography--an analysis of 422 examinations.


Intravenous pyelography in acute idiopathic inferior vena caval thrombosis.


The response of stem cells of intestinal mucosa to irradiation with 14 MeV neutrons.


The cobblestone appearance of the duodenal cap, duodenitis and hyperplasia of Brunner's glands.


Differences in survival of jejunal crypt cells after radiation delivered at different dose-rates.


Pyle's disease or craniometaphyseal dysplasia (tarda).


Evaluation of the dosimetry of intravenously administered 67Ga citrate from measurements of the distribution in male August-Marshall hybrid rats.


Asphyxiating thoracic dystrophy.

Asphyxiating thoracic dystrophy.


Ulcer in a Meckel's diverticulum demonstrated radiographically.


Osteoblastic metastases in carcinoma of pancreas.


Ovarian cyst presenting in the neonatal period.


Tissue-air ratio formulae in 60Co teletherapy dosimetry.


Extending the dynamic range of the photoscan display.


Radioimmunoassay of thyroid and steroid hormones.


Clinical applications of thyroid hormone measurement.


Radioimmunoassay of gastrin.

Radioimmunoassay of gastrin.


A bioassay for thyroid stimulating hormone.


Measurement of overnight fasting insulin values and modulations below this.


A dual isotope modification of the Schilling test.


The use of labelled fibrinogen in the detection and management of deep vein thrombosis.


New radioactive inulin determinations (hydroxymethyl-C14), inulin and inulin T for the measurement of glomerular filtration rate and extracellular fluid space.


13N solutions for research studies in pulmonary physiology.


A new radiopharmaceutical for lung scanning.


The value of scintiscanning in the diagnosis of hepatic tumours using both selenomethionine and technetium.


Evaluation of surgical ventricular shunts using sodium pertechnetate (Na99Tcm04).


Avulsion of the renal pelvis treated by ureterocalycostomy.


Multiple indicator dilution technique for measuring precapillary gas and water distribution volumes of the lung; studies performed on anaesthetised dogs and human volunteers under acute hypoxic stress.


The use of cephalexin monohydrate in chronic bacteriuria and acute urinary tract infection.


Uretero-ileostomy.

Uretero-ileostomy.


An improved system of local renal hypothermia. With special reference to the pseudorecurrence rate of staghorn calculi.


Segmental replacement of the ureter by a narrowed ileal loop.


Urinary presentation of cauda equina lesions without neurological symptoms.


Muscle water and electrolytes after ureterocolic anastomosis.


The problem of carcinoma of bilharzial bladder in Iraq.


Bladder "calculus" from water soluble lubricants.


Serology in the study of the relationship between S. haematobium infestation and cancer of the urinary bladder.


Management of clotting in arteriovenous cannulae in patients on regular dialysis therapy.


Hypermagnesaemic encephalopathy due to antacid ingestion occurring during regular dialysis treatment.


An instrument for ureteric catheterisation.


Depression and oral contraception.

Depression and oral contraception.


Analgesic nephropathy.

Analgesic nephropathy.


Reaching the top.

Reaching the top.


One grim spectre.

One grim spectre.


Fetal maturity.

Fetal maturity.


Phenacetin nephropathy, with particular reference to the effect of surgery. Sixteen patients suffering from phenacetin nephropathy were seen at one London hospital between June 1964 and January 1970. There were five deaths, three of them following a surgical operation. Phenacetin nephropathy occurs far more frequently than is generally considered. Unless patients are asked about the consumption of phenacetin routinely the diagnosis is usually missed. It is recommended that phenacetin and paracetamol should be available only on a doctor's prescription.


Resolution of pulmonary embolism.

Resolution of pulmonary embolism. To assess restoration of pulmonary perfusion after pulmonary embolism serial lung scans were carried out on 74 patients. Of these, one-third showed almost complete recovery, one-third improved, and the remainder either failed to improve or became worse. Perfusion was most rapidly restored in the first few days after the embolus and more slowly during the next two to three weeks.Untreated patients improved less often and had more new defects in perfusion than patients treated with anticoagulant therapy, no difference occurring in either the amount of improvement or in the rate of recovery of perfusion between patients treated with different anticoagulant regimens. There was evidence of further pulmonary emboli in 35% of treated patients, 82% of these occurring within two weeks of the initial embolus. Patients with defects in perfusion greater than 30% showed considerable improvement but recovered less well than those with smaller defects.


Control of heparin therapy.

Control of heparin therapy. Heparin therapy in 114 patients was controlled by daily blood tests-the whole blood coagulation time, kaolin-activated partial thromboplastin time of plasma, and plasma heparin assay. Bleeding episodes occurred in 7 out of 92 patients (7.6%) who had normal haemostatic mechanisms before therapy and in 11 out of 22 patients (50%) with defective haemostasis, mostly due to intravascular coagulation or renal failure. The dose of heparin ranged from 20,000 to 60,000 units in each 24-hour period. In some patients bleeding was related to overdosage, but in others the laboratory tests indicated satisfactory or suboptimal dosage at the time of bleeding. Though there were positive correlations between the results of the three tests, these were not close, and no one test was preferable. Hence laboratory control of heparin therapy is unsatisfactory and patients may bleed despite careful control of the dose by all three methods.


Depressive symptoms and oral contraceptives. Of 261 women who completed a self-rating scale for measuring depression, 168 were taking oral contraceptives and 93 were using physical methods of contraception. Of the group of women taking oral contraceptives 6.6% were more severely depressed than any of the control group. There was a significant variation in the depth of depression related to the day of the menstrual cycle in the control group. This association was not found in the oral contraceptive group, where premenstrual depression was limited to the one or two days preceding menstruation.Women taking a contraceptive containing lynoestrenol 2.5 mg. and mestranol 0.075 mg. showed a significantly increased incidence of pessimism, feelings of dissatisfaction, crying, and tension, compared with women taking other oral contraceptives and the control group.


Comparison of the efficacy of liquid and freeze-dried strains of B.C.G. vaccine in preventing tuberculosis. Analysis of the tuberculosis notifications and the statistics of B.C.G. vaccinations among 13-year-old schoolchildren in Birmingham, England, between 1953 and 1969 shows that the Copenhagen strain of B.C.G. (liquid batches issued 1953-61) and the Glaxo Laboratories strain (freeze-dried batches issued 1962-68) were of similar high efficacy in the prevention of tuberculosis. The method of analysis could be used for the surveillance of the protective efficacy of B.C.G. vaccine in other population groups where it is used routinely but not universally.


Efeect of temperature on hospital admissions for myocardial infarction in a subarctic area. In a study of the effect of mean daily temperature on the admission and fatality rates of 771 patients with myocardial infarction the admission rate was found to be significantly higher on cold (temperature below 0 degrees C.) than on warm (temperature above 0 degrees C.) days. The fatality rate was almost equal in cold and warm weather. Thus the seasonal fluctuation in the admission rate of patients with myocardial infarction is probably due to a direct effect of environmental temperature.


Toxoplasmal and toxocaral infections: a clinical investigation into their relationship. An investigation was carried out to determine whether a relationship existed between infections with Toxoplasma gondii and Toxocara canis. Antibodies were sought by the toxoplasma dye test and the toxocara skin sensitivity test. Sixty-seven patients were examined in the United Kingdom; 38 had positive toxoplasma dye tests, two of these being toxocara-positive; and 29 had negative dye tests, six of them being toxocara-positive. From the total of eight toxocarapositive patients antibodies to toxoplasma were detected in two, an incidence no greater than that expected for a normal population.Sera from 60 toxocara-positive African patients were examined; 20 possessed antibodies to Toxoplasma. Analysis according to age group or geographical location indicated that this incidence was no greater than that expected for patients without evidence of toxocaral infection.This study therefore showed no causal or clinically important relationship between toxoplasmal and toxocaral infections.


Treatment of premature labour with orciprenaline. The use of orciprenaline, a beta-adrenergic agent, in 30 patients with probable premature labour proved to be effective and safe to both mother and fetus under the conditions employed.


Metabolic findings in a patient with hyperosmolar non-ketoacidotic diabetic stupor.


Optic atrophy eight years after tuberculous meningitis.


Purpura fulminans treated with hyperbaric oxygen.


Acute renal failure.

Acute renal failure.


Operative cholangiography. Its effect on the practice of cholecystectomy.


Disaster planning. A major accident exercise.


Tropical splenomegaly syndrome.

Tropical splenomegaly syndrome.


Cardiac arrest and bone cement.

Cardiac arrest and bone cement.


Benign sixth-nerve palsy.

Benign sixth-nerve palsy.


Bloodstained tears.

Bloodstained tears.


Internal sphincterotomy.

Internal sphincterotomy.


ABO groups and myelomatosis.

ABO groups and myelomatosis.


Teratogenic drugs--R.C.G.P. survey.

Teratogenic drugs--R.C.G.P. survey.


Biological detergents.

Biological detergents.


Tales of error and indemnification.

Tales of error and indemnification.


Hepatitis in dialysis units.

Hepatitis in dialysis units.


Clinical use of prostaglandins.

Clinical use of prostaglandins.


Back to smoke pollution.

Back to smoke pollution.


Genital herpes and cervical cancer.

Genital herpes and cervical cancer.


Problems of chronic paronychia.

Problems of chronic paronychia.


Lactic acidosis.

Lactic acidosis.


Electroencephalographic prediction of fatal anoxic brain damage after resuscitation from cardiac arrest. Ninety-three electroencephalograms (E.E.G.s) were recorded within a week of cardiac resuscitation from 41 patients in whom the subsequent outcome was known to be either recovery of cerebral function or death with associated pathological evidence of gross anoxic brain damage. A statistical analysis of observations on these E.E.G.s yielded a discriminant function for predicting death or survival. Predictions based on each of the 93 individual E.E.G.s would have been correct in 92 and at a confidence level better than 99%. The same discriminant function was found to be applicable to a further 19 patients who died but did not undergo neuropathological studies and to 33 others in whom the clinical picture was complicated by such factors as uraemia or head injury. Thus it seems that the presence or absence of fatal brain damage after cardiac arrest can be reliably predicted from E.E.G.s taken within a week of resuscitation. An estimate of the probability of survival is now routinely included in the clinical report on each E.E.G. taken after cardiac arrest.


Outbreak of anticonvulsant intoxication in an Australian city. An outbreak of anticonvulsant intoxication occurred in epileptic patients in Australia during 1968-9. All affected patients studied in Brisbane were taking one brand of phenytoin. In 87% of them the blood phenytoin levels were above the therapeutic range. Reduction of phenytoin dosage relieved the intoxication in all patients. The excipient in the responsible phenytoin capsules had been changed several months before the outbreak, and this change was probably related causally to the altered blood phenytoin concentrations.


Reversible encephalopathy and acute renal failure after cephaloridine.


Gangrene of digits after chicken-pox.

Gangrene of digits after chicken-pox.


Vasculas complications in nephrotic syndrome: relationship to steroid therapy and accelerated thromboplastin generation. Arterial thrombosis and renal vein thrombosis occurred in two men and one woman, respectively, treated with steroids for the nephrotic syndrome. Raised serum cholesterol occurred in one patient only. Though bleeding, clotting, and prothrombin times, as well as the platelet counts, were normal, the rate of thromboplastin generation was increased in all three patients. Adding heparin to the plasma of one patient slowed the rate, and suggested that the raised rate could be due to removal or suppression of such normal circulating coagulation inhibitors. The thromboplastin generation test seems to be useful in diagnosing and managing such hypercoagulable states, and may help in further investigations of their causes.


Glomerulonephritis.

Glomerulonephritis.


A male sterilization clinic.

A male sterilization clinic. In the Cardiff Family Planning Association Clinic 330 men have been sterilized during the past 20 months. Selection for operation was made after a detailed discussion between husband, wife, and a Family Planning Association doctor, and with the general practitioner's agreement. The outpatient operation was performed under local anaesthetic by a surgeon. It was regarded as being successful or complete when two semen analyses showed azoospermia at an interval of one month.


Psychological aspects of vasectomy.

Psychological aspects of vasectomy. In a study to assess the psychosocial and sexual effects of contraceptive vasectomy by questionnaire and personal interview, 10 out of 82 respondents indicated some psychological problem arising from the operation. Five out of seven couples interviewed had histories of marital, sexual, or psychological instability. Screening of applicants for vasectomy is therefore recommended, pre-existing instability being a contraindication to the operation.


Attitudes to psychiatry.

Attitudes to psychiatry.


A vagal paradox.

A vagal paradox.


Renin activity in acute renal failure.

Renin activity in acute renal failure.


Osteoporosis and fluoride therapy.

Osteoporosis and fluoride therapy.


Coalworkers' pneumoconiosis.

Coalworkers' pneumoconiosis.


Salicylates and papillary necrosis.

Salicylates and papillary necrosis.


Myocardial infarction and the G.P.

Myocardial infarction and the G.P.


Phentolamine in heart block.

Phentolamine in heart block.


Adoption, mothers' and children.

Adoption, mothers' and children.


Reaction of amino acids with guanidinating agents.


Peroxidase-catalyzed conjugation of [4-14C]estradiol with albumin and thiols.


The activation of chymotrypsinogen by papain.


An examination of the relation between endogenous lipid and the activity of the phosphatidylglycerol-forming enzyme system in beef heart mitochondria and microsomes.


The regulation of protein synthesis in nephrotic rat liver ribosome preparations.


Mode of action of choline. V. Sequential changes in hepatic and serum lipids of choline-deficient rats.


Lichen substances. IV. Incorporation of pulvinic-14C acids into calycin by the lichen Pseudocyphellaria crocata.


The reaction of 2,4,6-trinitrobenzene sulfonic acid with pancreatic elastase.


Influence of the acceptor during transglucosylation by transglucosylamylase of Candida tropicalis.


Biosynthesis of Se-methylselenocysteine and S-methylcysteine in Astragalus bisulcatus.


New gene-enzyme system in Anopheles atroparvus: occurrence and frequencies of four alleles at the EST6 locus.


Genetic evidence for 'Darwinian' selection at the molecular level. II. Genetic analysis of cytoplasmically-inherited high and low suppressitivity in Saccharomyces cervisiae.


Serum proteins of the silver pheasant, Gennaeus nycthemerus.


Effect of antibiotics on carbohydrase activities of mouse small intestine.


Comparative studies on liver and kidney xanthine dehydrogenase in two breeds of domestic chicks (Gallus domesticus) during prolonged starvation.


The glycopeptide pattern of the porcine (Sus domesticus) and rabbit (Oryctolagus caniculus domesticus) corneal stroma.


Effects of hypoxia upon respiration and circulation in the dogfish Scyliorhinus stellaris.


DNA synthesis in the developing ovary of the housefly.


Normal serum glutamic oxalacetic transaminase and alkaline phosphatase levels in albino mice.


Activation of superior colliculus neurons and motor responses after electrical stimulation of the inferior colliculus.


Epileptic focus in the frog forebrain. Triggering of the focal discharge with sensory stimuli.


The midbrain tectum in visual relay.

The midbrain tectum in visual relay.


Evoked cortical potentials in prenatally irradiated rats.


Vulnerability of developing brain. I. Some lasting effects of x-irradiation.


Myelin synthesis in two demyelinating mutations in mice.


Distribution of thiamine phosphate esters in normal and thiamine-deficient brain.


Mechanisms of orientation discrimination in the rabbit.


Effect of para-chlorophenylalanine on basal forebrain stimulation.


Can hypothalamically induced escape behavior be conditioned?


Absence of visually influenced cells in auditory cortex of normal and congenitally deaf cats.


Association of genetic polymorphisms with embryonic mortality in the chicken. II. The B blood-group system and the pure and crossbred progeny of two populations.


Selection for a threshold character in Drosophila. 3. Genetic control of variability in plateaued populations.


Chromosomal basis of dosage compensation in Drosophila. II. The DNA replication patterns of the male X-chromosome in an autosome--X insertion in D. melanogaster.


DNA feeding and directed mutagenesis in Drosophila melanogaster.


Studies on genetic organization in higher organisms. 3. Confirmation of the single cistron-allele complementation model of organization of the maroon-like region of Drosophila melanogaster.


Polyacrylamide-agarose electrophoretic pattern of the RNA labelling in liver cytoplasm and total liver of 5-fluorouracil treated rats.


Effect of cortisol on the synthesis of DNA-like RNA contained in 30S ribonucleotprotein particles from rat liver.


Nurse staffing systems.

Nurse staffing systems.


Licensure of hospital personnel. 1.

Licensure of hospital personnel. 1.


Involvement of providers.

Involvement of providers.


Office landscaping.

Office landscaping.


The mental health practitioner.

The mental health practitioner.


The inner-city patient.

The inner-city patient.


Pharmacy supportive personnel.

Pharmacy supportive personnel.


Irrigating solutions.

Irrigating solutions.


Expanding a food service system.

Expanding a food service system.


Insulated trays facilitate meal delivery, improve food service.


OR scheduling methods.

OR scheduling methods.


Purchasing mathematics.

Purchasing mathematics.


On the structural view of affect.

On the structural view of affect.


Therapeutic playback, self objectification and the analytic process.


Action, acting out and the symptomatic act.


Research in psychoanalysis: experimental studies.


Negative therapeutic reaction.

Negative therapeutic reaction.


The scope of psychoanalyst as a consultant in colleges.


Effects of contrast media upon blood coagulation.


Measurement of lower extremity arteriovenous shunting with 131-I-macroaggregates of albumin.


Auxiliary methods in peripheral angiography of the extremities.


Congenital multi-cystic disease in the adult.


Xanthogranulomatous pyelonephritis--radiologic considerations.


The plain film diagnosis of acute ileo-ileal intussusception.


Positive identification of lung neoplasms with 197HgCl2.