Tomography of the temporal bone: a diagnostic aid in congenital deafness.


Thyroid metastases diagnosed by 99m Tc scanning. A case report.


Paget's disease of the patella.

Paget's disease of the patella.


Aortographic demonstration of massive bleeding from duodenal stump.


Erythropoiesis in the anemia of bone marrow failure. The quantitative relationship between red cell volume, erythropoietin level, and erythropoiesis was evaluated in 43 human beings. Results in normal man were compared with studies in patients with anemia from bone marrow failure and with polycythemia vera. The maximum erythropoietin excretion after bleeding normal men was similar to the basal levels found in patients with chronic anemia of similar magnitude. Although erythropoietin values were low in patients with polycythemia vera, bleeding evoked a normal response. In patients anemic from bone marrow failure, basal levels were elevated, and phlebotomy resulted in an increase consistent with the new level of anemia. These observations indicate that erythropoietin level is affected primarily by the degree of anemia and is not influenced by the duration of anemia. In normal subjects, a fivefold increase in urinary erythropoietin was associated with a doubling of erythropoiesis. Despite similar degrees of erythropoietin production, anemic patients with evidence of bone marrow in the lower extremities had greater red cell production. In patients with polycythemia vera, red cell production was inappropriately elevated with regard to the urinary erythropoietin excretion. Bone marrow maturation time was not shortened in patients anemic from bone marrow failure to the same degree as in bled, normal volunteers. In addition to an adequate level of erythropoietin production, normal bone marrow function is necessary for maximal shortening of maturation time.


Mechanism of action of thyroid hormones on erythrocyte 2,3-diphosphoglyceric acid synthesis. Normal erythrocytes, when incubated with thyroid hormone, were found to have increased levels of 2,3-diphosphoglyceric acid. In addition, a partially purified enzyme preparation, when incubated with either a 1,3-diphosphoglyceric acid generating system or 1,3-diphosphoglyceric acid directly, showed increased levels of 2,3-diphosphoglyceric acid when exposed to thyroid hormone. The hormonal effect was biphasic and was witnessed after 5 min of incubation. Substitution on the 3 and 5 positions of the basic thyronine molecule was essential for hormonal effect. It appears that thyroid hormone acts by directly stimulating the diphosphoglycerate mutase enzyme. The hormonal effect on 2,3-DPG synthesis may offer a biochemical explanation for the shift in the oxyhemoglobin dissociation curve observed in thyroid disorders.


Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. Transport of free fatty acids from the blood into the splanchnic region and their conversion to triglycerides of very low density lipoproteins, together with estimates of splanchnic oxidation of free fatty acids to ketones and to carbon dioxide and water, have been made in the postabsorptive state in seven normolipemic subjects, six with primary endogenous hyperlipemia and one each with primary dysbetalipoproteinemia and mixed hyperlipemia. Net systemic transport of free fatty acids into the blood was the same in normolipemic and hyperlipemic groups, but a greater fraction was taken up in the splanchnic region in the latter. Transport into the blood in very low density lipoproteins of triglyceride fatty acids derived from free fatty acids was proportional and bore the same relationship to splanchnic uptake of free fatty acids in the two groups. In normolipemic subjects, near equilibration of specific activities after 4 hr infusion of palmitate-1-(14)C showed that almost all triglyceride fatty acids of very low density lipoproteins and acetoacetate were derived from free fatty acids taken up in the splanchnic region. In the hyperlipemic subjects, equilibration of free fatty acidcarbon with acetoacetate was almost complete, but not with triglyceride fatty acids, owing at least in part to increased pool size. Comparison of the rate of equilibration of triglyceride fatty acids-(14)C with rate of inflow transport from the splanchnic region, together with other data, indicated that most of the circulating triglyceride fatty acids of very low density lipoproteins in hyperlipemic subjects were also derived from free fatty acids. Although mean inflow transport of triglyceride fatty acids was greater in the hyperlipemic subjects, it correlated poorly with their concentration and it appeared that efficiency of mechanisms for extrahepatic removal must be a major determinant of the concentration of triglycerides in blood plasma of the normolipemic as well as the hyperlipemic subjects. Estimates of splanchnic respiratory quotient supported the concept that oxidation of free fatty acids accounts for almost all of splanchnic oxygen consumption in the postabsorptive state. Splanchnic oxygen consumption was greater in the hyperlipemics, but fractional oxidation of free fatty acids to ketones was higher in normolipemic subjects. Calculations of splanchnic balance indicate that a larger fraction of free fatty acids was stored in lipids of splanchnic tissues in the hyperlipemics. No differences were found between the two groups in net splanchnic transport of glucose, lactate, or glycerol.


The role of hemoglobin heme loss in Heinz body formation: studies with a partially heme-deficient hemoglobin and with genetically unstable hemoglobins. A number of mutant hemoglobins are inordinately unstable, denaturing in circulating red cells into Heinz bodies, resulting in congenital Heinz body hemolytic anemia (CHBHA). We have emphasized that most such hemoglobins involve amino acid substitutions at sites neighboring the heme group of the beta-polypeptide chain, and have shown that heme binding to globin is diminished thereby. Thus, hemes were progressively lost from four unstable hemoglobins (Köln, Hammersmith, San Francisco, and Zürich) as they precipitated into Heinz bodies at 50 degrees C. The role of heme loss, especially from beta chains, in Heinz body formation was supported by studies with a hemoglobin synthesized to contain hemes only on its alpha chains (alpha(2) (heme)beta(2) (0)). The behavior of this compound, postulated to be an intermediary in the formation of Heinz bodies, mimicked that of the genetically unstable hemoglobins in several ways: (a) it precipitated at 50 degrees C into typical coccoid Heinz bodies; (b) as also observed with CHBHA hemoglobins this denaturation was virtually prevented by the heme ligands, cyanide or carbon monoxide, which inhibit further heme loss; it was potentiated by oxidation of hemes to the ferri- state, which accentuates heme loss; (c) the thiol groups of alpha(2) (heme)beta(2) (0) were hyperreactive, forming mixed disulfides with glutathione and membrane sulfhydryls at rates similar to those of CHBHA hemoglobins and 10 or more times that of normal hemoglobin A; (d) heme repletion of the protein molecules by the addition of crystalline hemin to either alpha(2) (heme)beta(2) (0) or to the genetically unstable hemoglobins, prevented their precipitation into Heinz bodies and normalized their aberrant electrophoretic behaviors; and (e) during Heinz body formation at 50 degrees C both alpha(2) (heme)beta(2) (0) and the genetically unstable hemoglobins released free alpha(heme)-chains into solution, suggesting that the bulk of the whitish, Heinz body precipitate is naked beta(8)-chains. We conclude that heme loss from mutant beta chains is an early step in Heinz body formation in several of the unstable hemoglobinopathies. The resulting hemedepleted compounds, of which synthetic alpha(2) (heme)beta(2) (0) is a prototype, are unstable, cleaving into beta(0)-chain precipitates (the bulk of the Heinz body material) and soluble, free alpha(heme)-chains (demonstrated previously in hemolysates from many patients with CHBHA).


The role of phosphate in the secretion of parathyroid hormone in man. In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.


On the measurement of cell adhesiveness.


Law and order.

Law and order.


Sulfated extracellular matrix production in the embryonic heart and adjacent tissues.


A simple calculator for the determination of the frequency of occurrence of blood group combinations.


Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse. The level of nucleoside deaminase was determined in extracts of mouse tissues obtained during a period of accelerated erythropoiesis induced by hypoxia, hemorrhage, or the injection of phenylhydrazine. Under these conditions a striking (10- to 100-fold) elevation of the enzyme activity occurred in the spleen. Similar results were obtained with the injection of purified erythropoietin. In control animals, only a trace of nucleoside deaminase activity was detected in the blood. During the reticulocyte response which followed erythropoietic stimulation, there was a sharp increase in the blood level of nucleoside deaminase, which rose up to 120 times that of control animals. By differential centrifugation, the enzyme was localized to the reticulocyte-rich fraction. Erythrocyte nucleoside deaminase remained elevated even after the reticulocyte count had fallen to normal in the phenylhydrazine-treated mice or to zero after the cessation of hypoxia. There was a very gradual decline in the enzyme activity in the blood which fell to the barely detectable control levels about 45 days after the initial reticulocyte response, a time period which corresponds to the survival of the mouse red blood cell. The persistence of high levels of nucleoside deaminase for the full life span of a generation of erythrocytes formed during stress, viewed in contrast to the virtual absence of the enzyme from normal erythrocytes of all ages, represents an enzymatic difference between the normal red blood cell and the cell produced under conditions of accelerated erythropoiesis.


An internal standard method for gas liquid chromatography: theory and derivation.


A study of idealized striated marks and their comparisons using models.


Petrol fires in closed rooms.

Petrol fires in closed rooms.


Separation of drugs from blood contaminated syringe washings.


Increased chloride conductance as the proximate cause of hydrogen ion concentration effects in Aplysia neurons. A fall in extracellular pH increased membrane conductance of the giant cell in the abdominal ganglion of Aplysia californica. Chloride conductance was trebled whereas potassium conductance was increased by 50%. Half the giant cells were hyperpolarized (2-8 mv) and half were depolarized (3-10 mv) by lowering the pH. The hyperpolarizing response always became a depolarizing response in half-chloride solutions. When internal chloride was increased electrophoretically, the hyperpolarization was either decreased or changed to depolarization. The depolarizing response was reduced or became a hyperpolarizing response after soaking the cell in 10.0 mM chloride, artificial seawater solution for 1 hr. Depolarization was unaffected when either external sodium, calcium, or magnesium was omitted. A glass micropipette having an organic liquid chloride ion exchanger in its tip was used to measure intracellular chloride activity in 14 giant cells; 7 had values of 27.7 +/- 1.8 mM (SEM) and 7 others 40.7 +/- 1.5 mM. Three of the first group were hyperpolarized when pH was lowered and three of the second group were depolarized. In all six cells, these changes of membrane potential were in the direction of the chloride equilibrium potential. Intracellular potassium activity was measured by means of a potassium ion exchanger microelectrode.


Linear electrical properties of the transverse tubules and surface membrane of skeletal muscle fibers. With the use of two intracellular microelectrodes and a circuit designed to compensate for the effects of stray capacitances around the electrodes, transfer impedance measurements were made at frequencies from 0.5 to 1000 c/s on frog sartorius muscle fibers bathed in 7.5 mM K Ringer solution. Complete AC cable analyses performed at 46, 100, 215, 464, and 1000 c/s showed that the fibers behaved as ideal one-dimensional cables having purely resistive internal impedances (R(i) = 102 +/- 11 Omega cm). Two circuits were considered for fiber inside-outside impedance, a four lumped parameter circuit and a parallel resistance and capacitance shunted by the input impedance of a lattice model for the T-system. Least squares fits to fiber input impedance phase angles were better with the latter circuit than with the former. With the use of the lattice model the specific capacitance of both the surface and transverse tubule membranes was found to be 1 microF/cm(2) and the internal resistivity of the tubules to be about 300 Omega cm.


Dicarboxylic amino acid influx across brush border of rabbit ileum. Effects of amino acid charge on the sodium-amino acid interaction. Glutamate and aspartate influxes across the brush border of rabbit intestine are saturable processes that are subject to competitive inhibition and are markedly influenced by the Na concentration in the mucosal solution. Lowering the Na concentration increases the amino acid concentration needed to elicit a half-maximal influx but does not significantly affect the maximal influx. The interaction between Na and anionic amino acid influx can be described by the same kinetic model that has been applied to the influxes of neutral amino acids and lysine. Comparison of the kinetic parameters for anionic, neutral, and cationic amino acids suggests that amino acid charge influences (a) the stability of the binary (amino acid-site) complex and (b) the affinity of this binary complex for the subsequent binding of Na. A mechanistic interpretation of these interactions is proposed.


Effects of intracellular adenosine-5'-diphosphate and orthophosphate on the sensitivity of sodium efflux from squid axon to external sodium and potassium. A study was made of sodium efflux from squid giant axon, and its sensitivity to external K and Na. When sodium efflux from untreated axons was strongly stimulated by K(o), Na(o) was inhibitory; when dependence on K(o) was low, Na(o) had a stimulatory effect. Incipient CN poisoning or apyrase injection, which produces high intracellular levels of ADP(1) and P(i), rendered sodium efflux less dependent on external K and more dependent on external Na. Injection of ADP, AMP, arginine, or creatine + creatine phosphokinase, all of which raise ADP levels without raising P(i) levels, had the same effect as incipient CN poisoning. P(i) injection had no effect on the K sensitivity of sodium efflux. Axons depleted of arginine and phosphoarginine by injection of arginase still lost their K sensitivity when the ATP:ADP ratio was lowered and regained it partially when the ratio was raised. Rough calculations show that sodium efflux is maximally K(o)-dependent when the ATP:ADP ratio is about 10:1, becomes insensitive to K(o) when the ratio is about 1:2, and is inhibited by K(o) when the ratio is about 1:10. Deoxy-ATP mimicked ADP when injected into intact axons. Excess Mg, as well as P(i), inhibited both strophanthidin-sensitive and strophanthidin-insensitive sodium efflux. An outline is presented for a model which might explain the effects of ADP, P(i) and deoxy-ATP.


The effect of Cambendazole on Trichinella spiralis infections in mice.


A simple conversion table for pH values to H+ n.equiv.-1.


Two-dimensional separation of urinary amino acids by high voltage paper electrophoresis and chromatography.


Evaluation of an immunological test for pregnancy.


A simple method of preparing monospecific anti-human fibrin serum in rabbits.


Ultramicro determination of electrolytes and urea.


Comparison of chemical and atomic absorption methods for estimating menstrual blood loss.


A rapid occult blood test using amidopyrine as oxygen acceptor.


A knife storage box.

A knife storage box.


A holder for specimen rods in the A.E.I. EM6B electron microscope.


An automated diluter suitable for use with the Unicam S.P. 90 Atomic absorption spectrophotometer.


A dual diluter for haematology.

A dual diluter for haematology.


Method for collecting plasma from small blood samples.


Effects of carbon dioxide on coccidian oocysts from 6 host species.


Specificity of sugar transport in Trypanosoma gambiense.


Synchronization of the cell cycle of Tetrahymena by stravation and refeeding.


The influence of hyaluronidase and hyaluronidase substrates on penetration of cultured cells by eimerian sporozoites.


A lecithinase from the amoeba Hartmannella rhysodes.


Do synchronizing temperature shifts inhibit RNA synthesis in Tetrahymena pyriformis?


Pneumocystis carinii delanoë, its ultrastructure and ultrastructural affinities.


Studies of messenger RNA during the cell cycle in synchronized mass cultures of Tetrahymena pyriformis GL by hybridization.


Unsuspected urinary infection in general practice. A SURVEY was undertaken to find the prevalence of asymptomatic bacteriuria in people in normal health who were patients of members of the North-west Faculty of the Royal College of General Practitioners. Midstream specimens were collected from 341 males and 456 females seen in visits to 19 practices in Lancashire and Cheshire. Three males and 45 females had > 10(5) bacteria/ml; three males and 26 females had > 50 pus cells/cu mm. Both significant bacteriuria and pyuria were found in three males and seven females. The percentage incidence varied in each practice from 0-24 per cent. About one third of the patients with significant bacteriuria or pyuria had urinary symptoms, but there were also 53 males and 104 females, who had urinary symptoms, whose urine was normal.The highest attendances were in those practices where the family doctor made the initial approach to the subjects.


Drug addiction and the law.

Drug addiction and the law.


Motor racing.

Motor racing.


The scope for co-operation between the medical social worker and the general practitioner.


Medical record systems with special reference to numerical filing.


Obstetrical chart.

Obstetrical chart.


Communication and co-operation within the primary health team. A survey of ten large practices.


Nutritive value of meat meals. II. Influence of raw materials and processing on protein quality.


Nutritive value of meat meals. I. Possible growth depressant factors.


Nutritive value of meat meals. 3. Value of meat meals as supplements to a cereal basal diet: limiting amino acids in these diets.


Child advocacy and ecological planning.

Child advocacy and ecological planning.


Ethical considerations in the "involuntary commitment" of children and in psychological testing as a part of legal procedures.


Exploitation and the generational conflict.


Hospitalizing the young: is it for their own good?


Mental health and social action programs for children and youth in international perspective.


Functions of hesitations in the speech of normal families and families of schizophrenic patients.


Training child care staff: pitfalls and promises.


Psychological scaling of linguistic properties.


A perceptual study of American English diphthongs.


School grades and group therapy.

School grades and group therapy.


Moving the hard to move.

Moving the hard to move.


Program evaluation: a proposed model for mental health services.


On nucleus component durations.

On nucleus component durations.


Observations on psychiatric services for the deaf.


The widow as a caregiver in a program of preventive intervention with other widows.


The New York City skid row Negro: some research findings.


Catholic Seminarians in a secular institution.


The role of the psychiatric consultant in the state rehabilitation agency.


School phobia and the fear of death.

School phobia and the fear of death.


Deaths in a youth program.

Deaths in a youth program.


Correlating the Fifteen Indices with Hospital Achievement Awards.


Perspectives of military and civilian retirement.


Secondary emotional reactions in children with learning disabilities.


Conflict management: preeminent challenge.


NAMH position statements on family life and sex education and marriage counselors. Family life and sex education.


On helping the disadvantaged.

On helping the disadvantaged.


Nondisjunction induced by x-rays in oocytes of Drosophila melanogaster.


X-ray-induced dominant lethal mutations in male guinea-pigs, hamsters and rabbits.


Mutagenesis of cultured mammalian cells by X-radiation and ultraviolet light.


The resistance of mature oocytes of Drosophila melanogaster to the induction of non-disjunction by X-rays.


Social perception of internal-external control.


Neuropsychological assessment of children with, without, and with questionable epileptogenic dysfunction.


Rhythm in motor performance.

Rhythm in motor performance.


Improving prediction of brain damage with the tactile performance test for a psychiatric population.


Expectancy and stimulus generalization in vigilance.


Note on Thysell's "Reaction Time of Single Motor Units".


Reply to Lieblich's note.

Reply to Lieblich's note.


Short-term visual restriction in visual and auditory discrimination.


Voice confrontation in individuals with normal and defective speech patterns.


Varieties of consciousness: comparison of some cognitive characteristics.


Detection of an invariant among irrelevant dimensions of different salience value.


K.D.K.-Oseretsky tests of motor development.


Some influences of visual angle and retinal speed on measures of the spiral aftereffect.


Response set on the Zung Self-Rating Depression Scale.


Personality traits of women athletes as measured by the Edwards Personal Preference Schedule.


Interpolated activity in short-term motor memory.


Monitoring performance on visual and auditory displays.


Spatial discrimination reversal learning for mice genetically selected for differing brain size: a supplementary report.


Time estimation, sequence effects and filling activities.


Isotonic strength and relative isotonic endurance.


Some EPPS differences between smokers and non-smokers.


Device for measuring voluntary response time to peripherally placed stimuli.


Brightness discrimination learning in caimans.


Modification of selected Bender designs and interpretation of the first graders' visual-perceptual maturation with implications for Gestalt theory.


Recovery of motor performance following startle.


Stimulus properties, frequency of exposure, and affective responding.


Note on word frequency as a factor in perception of category size.


Effects of age and intelligence on trail making test performance and validity.


Relationship between GSR, heart rate, and reversibility of a Necker Cube.


What is signalled by proximity?

What is signalled by proximity?


Intellectual functioning of deaf children.


Peripheral flicker fusion in psychiatric patients with EEG abnormality.


Effects of test anxiety and coacting groups on learning and performance.


Perception of mechanical causality.

Perception of mechanical causality.


An effective therapeutic method for the LSD user.


Repeated presentation of stimuli and production of original responses.


Sensors.

Sensors.


Principles of engineering design.

Principles of engineering design.


Developing viable medical equipment, in general and for patient monitoring.


The hazard of electrocution during patient monitoring.


Patient monitoring: on-line computing.

Patient monitoring: on-line computing.


A clinical computer and monitor.

A clinical computer and monitor.


The patient-sensor interface.

The patient-sensor interface.


User needs of patients and nurses in clinical monitoring.


Monitoring requirements in patients with acute myocardial infarction.


Anaesthetic requirements in patient monitoring.


The treatment of varicose leg ulcers by hyperbaric oxygen.


A bedside computer in foetal assessment.


An acceptable slow-release phosphate preparation "slow P".


Axillary skin excision as a treatment for axillary hyperhidrosis.


Mass detection of bacteriuria by combination of two screening tests.


P wave abnormalities with myocardial infarction: an aid to the diagnosis of left ventricular failure.


Pneumatosis cystoides intestinalis.

Pneumatosis cystoides intestinalis.


Isobutyl cyanoacrylate as a skin adhesive.


Hypercalcaemia in thyrotoxicosis with and without hyperparathyroidism.


Bilateral cortical necrosis of the kidneys following snakebite.


Numerical study of oxygen uptake by layers of hemoglobin solution.


Hypervitaminosis D, anaemia and renal failure.


A graphical analysis of oxygen transfer in fish.


A critical evaluation of a nitrogen rebreathing method for the estimation of Pv02.


Displacement of oxygen dissociation curves and red cell cation exchange in chronic hypercapnia.


Influence of the cyclical pattern of ventilatory flow on pulmonary gas exchange.


The nature of the ventilatory period in crocodilian respiration.


Control of breathing in experimental anemia.


Quantitative recovery of phospholipids from alveolar wash.


A serological survey of the small mammals for plague in southern Africa.


The logic and process of certification of mentally disordered patients.


The control of postoperative pain.

The control of postoperative pain.


On the histogenesis of the ovarian interstitial gland in rabbits. I. Primary interstitial gland.


Protein absorption and transport by the guinea pig visceral yolk sac placenta.


The fine structure of the stannius body of the guppy and its response to deionized water.


Ultrastructure of the bone marrow of the frog.


The developing bronchial arteries in a fetus of the twelfth week.


Method for hydrolysis and isolation of plasmalogen-bound fatty aldehydes.


Selective determination of inorganic mercury in the presence of organomercurial compounds in biological material.


A rapid assay for binding estradiol to uterine receptor(s).


A polarographic method for the rapid determination of glucose with glucose oxidase.


Some S-alkyl derivatives of cysteine suitable for sequence determination by the phenylisothiocyanate technique.


Gamma counting of iodine-125 using a metal-loaded liquid scintillator.


Purity and purification of 14C-lysine.

Purity and purification of 14C-lysine.


Determination of the incorporation of 14C- or 3H-labeled precursors into macromolecules of ascites tumor cells by direct scanning and by liquid scintillation counting.


Mass spectral fragmentation of trimethylsilyl derivatives of 2-amino-4-hydroxypteridines: a method of identification.


An accelerated step-gradient procedure for the automatic analysis of collagen hydrolyzates.


Enzymic analysis of rabbit skeletal muscle carbohydrate.


Determination of iodoamino acids and inorganic iodide by thin-layer chromatography.


Automated system for ion-exchange chromatography of saccharides.


Separation of monoglucosiduronate conjugates of estrone and l7 beta-estradiol by DEAE-sephadex chromatography.


Determination of alpha-acyl-alpha-hydroxy acids in biological fluids by head-space gas chromatography.


A semiautomated procedure for determination of adenosine triphosphate.


Studies on 4-methylumbelliferone caprylate as a substrate for hog pancreatic lipase.


Determination of ATP in Chlorella with the luciferin-luciferase enzyme system.


Tremorgenic toxins from Penicillia. I. Colorimetric determination of tremortins A and B.


Automated potentiometric procedure of esterase assay.


Reactions of hydroxylamine with acetoacetyl thioesters or ethyl acetoacetate.


Acute glomerulonephritis with prolonged oliguria. An analysis of 29 cases.


Centrilobular hepatic necrosis and acute renal failure in "solvent sniffers".


Recognition of partial defects in antidiuretic hormone secretion.


Effects of coumarin compounds on the fetus.


Use of professional time by internists and general practitioners in group and solo practice.


Serum complement defects in periodic diseases.


Pseudogout with low values of alkaline phosphatase in the synovial fluid.


Methemoglobinemia from well water nitrates: a complication of home dialysis.


Tuberculin skin-test conversion in Vietnam. 1969 annual skin-test reports of Navy and Marine Corps.


Pulmonary angiothrombosis caused by "blue velvet" addiction.


The importance of patient training in home hemodialysis.


Medical limits of criminality.

Medical limits of criminality.


Glucagon and pheochromocytoma.

Glucagon and pheochromocytoma.


Vasectomy and adverse psychological reactions.


"Ouch-ouch" disease: the osteomalacia of cadmium nephropathy.


Transtracheal aspiration.

Transtracheal aspiration.


Endotracheal intubation.

Endotracheal intubation.


Inflammatory bowel disease and water supply.


Subclinical intestinal parasitic infections in military personnel with malaria.


Cryoproteins in poststreptococcal glomerulonephritis.


Acute ethchlorvynol (Placidyl) intoxication.


Chromosome karyotype 45,X-46,XY follow-up.


Deafness from furosemide.

Deafness from furosemide.


Atherosclerosis and mitochondria.

Atherosclerosis and mitochondria.


Chloride wasting and potassium depletion.


Posttraumatic bacterial meningitis.

Posttraumatic bacterial meningitis.


Thoracic injuries in combat casualties in Vietnam.


Pathophysiological alterations in perfused and nonperfused lungs during cardiopulmonary bypass.


Clinical experience with a membrane pump-oxygenator.


Automatic-demand pump for cardiopulmonary bypass.


Congenital mitral insufficiency. Results in unusual lesions.


Clinical use of tissue adhesive as an adjunct in pulmonary surgery.


Drainage patterns of internal mammary artery implant flow and the effect of implant clamping on coronary sinus flow.


The behavior of dacron felt tubes as vascular prostheses.


After fifty, what?

After fifty, what?


Experimental actinomycosis in mice. Study of pathogenesis.


Early renal changes in sickle cell anemia.


Electropotentials of surgical specimens.


Cause of death in 339 Alaskan natives as determined by autopsy.


Epithelial cysts related to sella turcica. Proposed origin from neuroepithelium.


Glycogenic acanthosis of the esophagus.

Glycogenic acanthosis of the esophagus.


Essential postmortem findings in the traffic accident victim.


Oxygen poisoning in mice. Ultrastructural and surfactant studies during exposure and recovery.


Carcinoma of the infant vagina. A distinctive tumor.


Effect of thrombogenic and atherogenic diets on aspects of hepatic energy metabolism in rats.


Evidence of beta structure in Mycoplasma membranes. Circular dichroism, optical rotatory dispersion, and infrared studies.


Platelet function in the Bantu.

Platelet function in the Bantu.


Photochemistry of thymidine in ice.

Photochemistry of thymidine in ice.


Lipid biosynthesis in rat-liver slices: effects of ions, ATP and substrate concentration on glycerol incorporation.


Aggregation patterns and release of adenosine diphosphate from guinea pig platelets.


Glycerolipid biosynthesis by Mycoplasms strain Y.


Fatty acid uptake by the brain. 3. Incorporation of (1-14C)oleic acid into the adult rat brain.


Effects of agents altering vascular calcium in experimental atherosclerosis.


Biochemical changes in Bifidobacterium bifidum var. Pennsylvanicus after cell wall inhibition. II. Fatty acid composition.


Sterol metabolism. 9.26-hydroxycholesterol levels in the human aorta.


Properties of the phospholipase D from peanut seeds.


Characterization of gangliosides from fish brain.


Cyanolipids of Stocksia brahuica Benth. seed oil.


Metabolism of radioactive estrone by rats.


Decreased esterification of (3H)cholesterol by serum from partially hepatectomized rats in vitro.


Position of double bonds in the fatty acids of cholesterol esters from human aorta.


Experimental coronary atherosclerosis in rabbits.


Modification of enzyme activities in experimental atherosclerosis in the rabbit.


Composition of glycopeptides obtained by proteolytic digestion of the media of porcine aorta.


A temperature-sensitive lipoprotein from abnormal egg yolk.


On the mechanism of enzymatic phosphatidylation. Biosynthesis of cardiolipin catalyzed by phospholipase D.


Severe agranulocytosis during para-aminosalicylic acid therapy.


Pulmonary neurilemmoma.

Pulmonary neurilemmoma.


Pulmonary tuberculosis, isoniazid and cancer.


Operative cholangiography.

Operative cholangiography.


Delayed ileorectal anastomosis in the surgery of ulcerative colitis.


Chronic beryllium disease: a new case following exposure in 1961.


Malignant melanoma of the anal canal.

Malignant melanoma of the anal canal.


The aetiology and management of branchial cysts.


Dysphagia following colon pedicle grafts.


Serial serum cholesterol estimations after biliary-tract surgery.


Management of paroxysms of hypertension in patients with phaeochromocytomas.


Some observations on the behaviour of isolated and interposed jejunal and ileal segments in the rabbit.


Carcinoma of the large intestine with survival in a child of nine and in his father. A study of carcinoma of the colon with particular reference to children.


Postoperative wound infection: a computer analysis.


The half life (T and one-half) of synthetic human gastrin I in man.


The dose response of the electrical activity, motor activity, and acid secretion to an i.v. infusion of pentagastrin.


The thymic influence on immunological recovery from antilymphocytic serum therapy.


Total blood-flow, pulsatile blood-flow, and tissue anoxia in apparently ischaemic feet.


An in vivo study of the blood-flow patterns across the normal mitral valve.


The effects of hypoxia and hyperoxia on renal blood-flow.


Species differences in response to renal ischaemia.


Contributions of Canadian research to medicine. Opening remarks.


Contributions of Canadian research to medicine.  Address of welcome.


Angel A, Steiner G: The metabolism of white and brown adipose tissue.


Calcitonin and calcium metabolism.

Calcitonin and calcium metabolism.


Vascular adjustments during the development of shock.


Platelet aggregation and the platelet release reaction in thromboembolism.


Temperature-sensitive conditional lethal mutants of somatic cells.


Physical and chemical studies of sperm production.


Sphingolipid biosynthesis by a rat brain particulate fraction.


On blood groups.

On blood groups.


The galactosyl moiety of brain cerebrosides.


Gangliosides of extraneuronal tissue.

Gangliosides of extraneuronal tissue.


New developments in the study of ganglioside structures.


Tissue culture studies in the lipid storage disorders.


Metabolic disorders of sphingolipid metabolism in man.


The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion.


Partial syntheses of the carbohydrate chain of brain gangliosides.


Glycosphingolipids having blood-group ABH and Lewis specificities.


Chemistry and pharmacology of fluphenazine decanote.


Long-acting, antipsychotic agents and extrapyramidal side effects.


Long-acting drug treatment in overall psychiatric management.


The effectiveness of parenteral administration of fluphenazine decanoate in the treatment of chronic schizophrenics.


Private ambulatory patients treated with fluphenazine enanthate.


A clinical evaluation of fluphenazine enanthate.


Fluphenazine hydrochloride and enanthate in the management of chronic psychosis.


Symposium on long-acting phenothiazines in psychiatry. Introduction.


The philosophy of long-acting medication in psychiatry.


Activity in the optic tract and lateral geniculate nucleus of th cat during the first moments of light adaptation in the scotopic region.


An experimental electron microscopic study on the striatonigral projection in the cat.


Differentiation between slow cortical potentials associated with motor and mental acts in man.


Activity of movement sensitive neurons of the cat's tectum opticum during spontaneous eye movements.


A bizarre cause for pruritus-infestation with onchocercaria.


Effects of cold periods on the stimulus-response system of Phycomyces. The sporangiophores of Phycomyces do not exhibit phototropic responses when growth is arrested reversibly by cooling to 1 degrees C. Unilateral UV stimuli (254 nm) applied during cold periods are stored for at least 2 hr and produce tropic responses away from the light after warm-up. During the cold period dark adaptation proceeds at a rate which decreases with the temperature.


Antimetabolite therapy of psoriasis.

Antimetabolite therapy of psoriasis.


Influence of polyvalent cations on the activation of muscle end plate receptors. The influence of polyvalent cations on the activation of end plate receptors has been studied in vitro on the sartorius muscle of the frog. In the absence of extracellular calcium, the sensitivity of the receptors to depolarizing quaternary ammonium salts was markedly reduced. Maximum receptor activation occurred in those fibers equilibrated in 1.8 mM calcium Ringer solution, with the response being reduced as the calcium concentration was raised or lowered. Magnesium was less efficient than calcium in regulating the sensitivity of the end plate receptors, the maximum receptor response occurring in those fibers equilibrated in 8 mM magnesium Ringer solution. In the presence of lanthanum the end plate response to carbamylcholine or acetylcholine was enhanced. Lanthanum increased the conductance change produced by carbamylcholine both in polarized and in potassium-depolarized fibers. The application of 10(-2) mM lanthanum to the end plate increased MEPP's amplitude, rise time, and half-fall time by 19, 54, and 45%, respectively. The results suggest that polyvalent cations influence postjunctional membrane receptor processes in addition to their well-documented prejunctional action.


Sodium movements in the human red blood cell. Measurements were made of the sodium outflux rate constant, (o)k(Na), and sodium influx rate constant, (i)k(Na), at varying concentrations of extracellular (Na(o)) and intracellular (Na(c)) sodium. (o)k(Na) increases with increasing [Na(o)] in the presence of extracellular potassium (K(o)) and in solutions containing ouabain. In K-free solutions which do not contain ouabain, (o)k(Na) falls as [Na(o)] rises from 0 to 6 mM; above 6 mM, (o)k(Na) increases with increasing [Na(o)]. Part of the Na outflux which occurs in solutions free of Na and K disappears when the cells are starved or when the measurements are made in solutions containing ouabain. As [Na(o)] increases from 0 to 6 mM, (i)k(Na) decreases, suggesting that sites involved in the sodium influx are becoming saturated. As [Na(c)] increases, (o)k(Na) at first increases and then decreases; this relation between (o)k(Na) and [Na(c)] is found when the measurements are made in high Na, high K solutions; high Na, K-free solutions; and in (Na + K)-free solutions. The relation may be the consequence of the requirement that more than one Na ion must react with the transport mechanism at the inner surface of the membrane before transport occurs. Further evidence has been obtained that the ouabain-inhibited Na outflux and Na influx in K-free solutions represent an exchange of Na(c) for Na(o) via the Na-K pump mechanism.


Photoreceptor potentials of opposite polarity in the eye of the scallop, Pecten irradians. Intracellular recordings were obtained from single visual cells of the scallop, Pecten irradians. Two types of units are found. One type gives a graded, depolarizing response to light and the other a graded, hyperpolarizing response. The depolarizing cells are 2-3 log units more sensitive to light and have a longer latency than the hyperpolarizing type. At high light intensities the depolarizing cells are inactivated while the hyperpolarizing cells maintain their responses. When action potentials are seen they occur during illumination in depolarizing cells ("on" response) and after illumination in hyperpolarizing cells ("off" response). The evidence suggests that the depolarizing responses are from the microvilli-brearing proximal cells, and the hyperpolarizing responses from the ciliary-type distal cells of the retina, and that both responses are directly produced by light.


Membrane conductances and spectral sensitivities of Pecten photoreceptors. The electrical and spectral properties of depolarizing (proximal) and hyperpolarizing (distal) photoreceptors in the eye of the scallop, Pecten irradians, were examined. Both depolarizing and hyperpolarizing responses are associated with an increase in membrane conductance; in addition, the depolarizing response is characterized by a secondary decrease in conductance at light intensities which inactivate the response. Both responses can be reversed in polarity by applied current across the cell membrane. The depolarizing response has a reversal potential of approximately +10 mv, whereas the estimated reversal potential for the hyperpolarizing response is near -70 mv. The two responses have the same spectral sensitivity function, which agrees with a Dartnall nomogram for a rhodospin with a lambda(max) at 500 nm. It is suggested that the photochemical reactions produce different end products which give responses of opposite polarity in proximal and distal cells, or alternatively, that the reactions of the respective cell membranes to the same end product are different.


Newer topical therapy in dermatology.

Newer topical therapy in dermatology.


Further studies of the effect of calcium on the time course of action of carbamylcholine at the neuromuscular junction. The rate at which the postjunctional membrane of muscle fibers becomes desensitized to the action of carbamylcholine is increased after the muscle has been soaked in solutions containing increased concentrations of calcium. Some further aspects of this effect of calcium were investigated by measuring changes in the input resistance of single fibers of the frog sartorius during local perfusion of the neuromuscular junction with 2.73 x 10(-3)M carbamylcholine in isolated muscles immersed in 165 mM potassium acetate. It was found that (a) sudden changes in the local concentration of calcium brought about by perfusing fibers with carbamylcholine solutions containing 20 mM calcium, 40 mM oxalate, or 40 mM EDTA were followed within 20 sec by marked changes in the rate of desensitization; (b) prior to 13 sec after the introduction of carbamylcholine, however, no effect on the input resistance could be detected even though the muscle had been presoaked in 10 mM calcium; (c) the ability of high concentrations of calcium to bring about rapid desensitization disappears when a lower concentration of carbamylcholine (0.137 x 10(-3)M) is applied to the muscle fiber. These findings suggest that calcium present in the extracellular fluid can act directly on the postjunctional membrane to promote the desensitization process and that an increased permeability of the membrane to calcium brought about by the presence of carbamylcholine is a factor which contributes to this action.


A study of age at onset of leprosy.

A study of age at onset of leprosy.


Experimental osteomyelitis. I. A description of the model.


Acid phosphatase activity during phases of growth in Candida albicans.


Ultraviolet wavelength factors in solar radiation and skin cancer.


Changing ecology of bacterial infections as related to antibacterial therapy.


Hepatitis virus: effect of heat on the infectivity and antigenicity of the MS-1 and MS-2 strains.


The effect of cryptococcin on leukocytic migration.


Antibiotic synergism against enterococci.


The effects of selenium and tellurium compounds on pigmentation of granules of Trichomycosis axillaris.


Thoracotracheostomy after resection of the larynx and cervical trachea for cancer.


Histiocytosis X.

Histiocytosis X.


Histopathological and histochemical studies on atrophic rhinitis.


Septoplasty--a new technique.

Septoplasty--a new technique.


A new material for laryngeal prosthesis.


Atypical cases of tubercular lymphadenitis.


Foreign body nasopharynx.

Foreign body nasopharynx.


Rhinolith perforating the hard palate.

Rhinolith perforating the hard palate.


Post traumatic thoracic duct fistulae in the neck.


Secondary malignant tumour of the temporal bone.


Liver polysome patterns of rats fed amino acid imbalanced diets.


65Zn absorption rate following single duodenal dosing in calves fed zinc-deficient or control diets.


Effect of age on glucose, reducing sugars and plasma insulin in blood of milk-fed calves.


Effect of level of total nitrogen intake on second limiting amino acid in corn for humans.


Comparison of scandium-46 and cerium-144 as nonabsorbed reference materials in studies with cattle.


Qualitative assessment of supplemental amino acid needs for growing lambs fed urea as the sole nitrogen source.


Quantitative assessment of supplemental amino acid needs for growing lambs fed urea as the sole nitrogen source.


Effect of curcumin on serum and liver cholesterol levels in the rat.


Effect of dietary egg and carbohydrate on hexosemonophosphate shunt dehydrogenases and lipids of liver in rats.


Effects of short-chain fatty acids, feeding, fasting and type of diet on plasma insulin levels in sheep.


Effect of long-term physical exercise on bile sterols, fecal fat and fatty acid metabolism in rats.


Influence of dietary l,3-butanediol on metabolites and enzymes involved in gluconeogenesis and lipogenesis in rats.


Effect of dietary Sterculia foetida oil on the migration of 59Fe across the egg yolk vitelline membrane to albumen in stored eggs.


Response of adult rats to low dietary levels of essential amino acids.


Work is a four letter word. A report from the Long Range Planning Committee.


The management of external eye infections in industry.


Disease of the external eye.

Disease of the external eye.


Where does BOSH belong?

Where does BOSH belong?


Problems in the gravimetric measurement of respirable coal mine dust.


The management of staff in general practice. Manpower planning in the Health Service.


The management of staff in general practice. Introduction.


The management of staff in general practice. Chairman's summary.


The management of staff in general practice. A systematic approach to selection.


The management of staff in general practice. The nurse--a luxury or a necessity in general practice?


The clerical ancillaires: their work and their worth.


The management of staff in general practice. Training the administrative worker for general practice.


The management of staff in general practice. Who bears the brunt?


Man, milieu and malady. Crisis and mental illness.


Man, milieu and malady. The tower in Siloam.


Man, milieu and malady. Human behavior in the built environment.


Man, milieu and malady. Medicine and the State. Past, present and future relationships.


Effect of alpha-tocopherol on lipid peroxide production and hemolysis following mechanical trauma to blood.


Acceleration of wound healing induced by enriched collagen solutions. Preliminary report.


Energy metabolism in healing skin wounds.


Renovascular hypertension: the diagnostic value of renal vein renin ratios.


Unilateral renal vein thrombosis and nephrotic syndrome.


Current results from primary and secondary treatment of renal cell carcinoma.


Spontaneous rupture of the collecting system of the kidney: an evaluation.


Ectopic opening of the ureter into the seminal vesicle: report of case.


Carcinoma of the colon following ureterosigmoidostomy: report of a case.


An improved concept in optics applied to cystoscopy.


Failure of the automatic bladder concept in the management of the complete upper motor neuron neurogenic bladder.


Case report of a congenital urethro-vaso-cutaneous fistula.


The physiology of the internal urinary sphincter.


Diffusion of sulfonamides from plasma into prostatic fluid.


The functional anatomy of urologic cryosurgical unit and its relation to the technique, complications and results of cryosurgery of the prostate.


A comparative study of relative incidence of stone types between a transient military population and the indigenous population of the Hawaiian Islands.


Applications of the dermo-jet in urology.


Incidence of retrograde ejaculation following bladder neck revision as a child.


Torsion of testicular appendages: presentation of 43 new cases and a collective review.


Torsion of the spermatic cord: a review of the literature and an analysis of 70 new cases.


Acute scrotum in children with emphasis on torsion of spermatic cord.


Reifenstein's syndrome: hereditary familial hypogonadism with hypospadias and gynecomastia.


Biological treatment of bleach plant wastes.


Epithelial-cell renewal in cultured duodenal biopsies in celiac sprue.


Glutathione synthetase deficiency as a cause of hereditary hemolytic disease.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Normal laboratory values.


Hormones, horoscopes, and patient care.

Hormones, horoscopes, and patient care.


Problems in developing a respiratory vaccine.


Dopamine analogues for studies of parkinsonism.


Plasmapheresis in acute pulmonary edema.


Action of chloramphenicol.

Action of chloramphenicol.


Salmonellosis and schistosomiasis of urinary tract.


Screening for rubella during pregnancy.

Screening for rubella during pregnancy.


Lead release from earthenware.

Lead release from earthenware.


Research on the effects of alcohol.

Research on the effects of alcohol.


A helmet for every driver.

A helmet for every driver.


Race and poverty.

Race and poverty.


Licensure problems of foreign medical graduates.


To draw a new line.

To draw a new line.


Homosexuals in medicine.

Homosexuals in medicine.


The determination of tryptophan in biological materials.


Automated analysis of peptides.

Automated analysis of peptides.


Determination of total amino acid concentrations in plasma.


Automated clinical chemistry.

Automated clinical chemistry.


The maintenance of analytical quality in the automated laboratory.


Recent advances in amino acid analysis.

Recent advances in amino acid analysis.


The first computer at a nutritional research institute: how its use has evolved.


Diet assessment and formulation in human nutrition.


Logging data in digital form.

Logging data in digital form.


The impact of computer analysis on the design of dietary surveys.


Nutritional problems of urban communities.


Statistics and computers--a worked example.


Food in nineteenth century England: nutrition in the first urban society.


The growth and nature of urban areas in developing countries.


The social, economic and marketing aspects of diffusing low-cost protein-enriched foods in urban Africa and the Third World.


Food supplies for urban populations in developing countries.


Factors affecting the nutritional status of urban communities.


Protein deficiency in urban and rural areas: its measurement, size and nature.


Plant breeding and nutrition.

Plant breeding and nutrition.


The breeding of wheat and maize with improved nutritional value.


Practical problems concerning the marketing of cereals with improved protein value.


Total nitrogen determination.

Total nitrogen determination.


Influence of transcription techniques on the precision of autoanalyser assays.


Nitrogen balance by Technicon AutoAnalyzer.


Problems associated with the automated analysis of mixtures of amino acids.


Response to different levels of supplementation with copper sulphate of diets for growing pigs.


Dietary cyclamate and cyclohexylamine excretion in man.


Some effects of feeding supplements of maize meal and sodium bicarbonate upon the digestion of forage cellulose by sheep.


The production of amines in the alimentary tract of the pig in relation to dietary lactobacilli, weaning and post-weaning diarrhoea. 1. In vivo studies of intestinal and urinary amines.


The production of amines in the alimentary tract of the pig in relation to dietary lactobacilli, weaning and post-weaning diarrhoea. 2. In vitro studies of the catabolic activity of the small intestinal microflora.


Effects of fractions from navy beans (Phaseolus vulgaris) on germ-free and conventional chicks.


The effect of intestinal coccidiosis upon energy utilization in the chick.


Diet, leisure activity and skinfold measurements of sedentary men.


Vitamins B and C and tongue signs in adolescents.


The absorption of micellar lipid by the small intestine of the sheep.


Absence of effect of thiamine and other vitamins on duration of myotatic.


The relationship between sucrose intake, plasma insulin and platelet adhesiveness in men with and without occlusive atherosclerosis.


Dietary sucrose and the behaviour of blood platelets.


The effect of undernutrition and subsequent rehabilitation on the growth and chemical composition of the cerebellum, brainstem and fore-brain of the rat.


Availability for rats of the lysine in field beans (Vicia faba L.).


Dietary carbohydrate, exercise and hepatic pyruvate kinase in the rat.


The value of BP-protein concentrate for growing pigs.


How to set about it.

How to set about it.


A method of posterior bone block for paralytic drop foot in children.


Problems and fallacies of field studies in Africa with special reference to cancer surveys.


Percutaneous renal biopsy in children: the use of a disposable needle.


Milestones in the history of diabetes--a brief survey.


Hypertension in patients on maintenance haemodialysis.


Non-specific agglutination reactions with Mycoplasma gallisepticum antigens.


Tubular and interstitial nephritis produced by homologous heart homogenate in rabbits. 1. Description of kidney lesions.


The incidence and frequency of Mallory bodies in 1,100 consecutive liver biopsies.


Fibro-adenomatosis and breast carcinoma. Enzyme-histochemical studies.


Place of renin formation in rabbit uterus.


Fatty change in papillary heart muscle and in its arterioles. Analysis of a material of 262 autopsies.


Pulmonary air embolization in the dog: postmortem findings.


Benzene induced chromosome abnormalities in rat bone marrow cells.


The value of estimation of radicality in cases of carcinoma in situ treated with conization. A histologic and cytologic study of a 5-year material.


Trauma and intravascular coagulation.

Trauma and intravascular coagulation.


Use of I-125-fibrinogen for determination of intravascular coagulation in vivo in various organs in the dog.


Intravascular coagulation in the kidney in experimental burns.


Density dependent cell cycle inhibition--a universal growth control among normal animal cells.


Long term culture of bone-marrow biopsies and peripheral blood leucocytes from patients with multiple myeloma.


A new histochemical technique for demonstration of histamine in mast cells by o-phthalaldehyde (OPT) reaction.


Quantitative cytochemical studies on the effect of early undernutrition on the postnatal development of neurons.


Lysosomal changes during castration-induced prostatic involution in the rat.


Synthesis and degradation of microsomal membrane constituents.


Septic gonorrheal dermatitis.

Septic gonorrheal dermatitis.


Laparotomy in cases of unexplained fever.


Fat cell necrosis in experimentally induced acute pancreatitis in the rat.


The application of a tidal flow culture method to the study of histological and lactate dehydrogenase (LDH)-isoenzymatic changes in primary mouse lung cell cultures.


Lactate dehydrogenase isoenzyme patterns in oral leukoplakias and in clinically uninvolved oral mucosa of the same persons.


Lactate dehydrogenase isoenzyme patterns in leukoplakia, submucous fibrosis and carcinoma of the oral mucosa in south Indians.


Changes in the connective tissue and inflammatory response to Ehrlich's carcinoma following treatment of the host mice with butazolidine.


Changes in the lymphoid system following the intravenous injection of phytohaemagglutinin in mice. A pilot study.


Number and structure of mitochondria in lymphocytes cultured at different oxygen tensions.


Chromosome aberrations in Fanconi anaemia.


Alteration of karyotypic profiles in human cancerous effusion following treatment with antineoplastic drug.


Histological changes in liver biopsies from patients with surgical bile duct disorders.


Cardial lesions in (CBA x DBA-2)f1 mice bearing transplanted plasma cell neoplasms and in untreated DBA-2 mice.


In vitro assay of the stimulatory effect on bone marrow cell proliferation of sera taken after chlorambucil treatment.


Histochemical and ultrastructural properties of the classical inclusion body in neurones infected with herpes simplex virus.


The intrarenal vascular alterations in nephrotoxic serum nephritis and their relationship to the development of hypertension.


Regulation of human and rat brain metabolism: inhibitory action of phenylalanine and phenylpyruvate on glycolysis, protein, lipid, DNA, and RNA metabolism.


Induction of microsomal drug-metabolizing enzymes in regenerating liver.


Regulation of flavoprotein enzymes in hypothyroidism and in riboflavin deficiency.


The sterol precursors of cholesterol in normal and tumor tissues.


Alterations in enzyme activity in tumors and the implications for chemotherapy.


Hormones and substrates in the regulation of gluconeogenesis in fasting man.


Mechanisms of enzyme modulation involving deoxycytidylate deaminase and thymidylate synthetase.


Phylogenic aspects of different regulatory mechanisms of glutamine metabolism.


Genetically determined electrophoretic variants of human red cell NADH diaphorase.


Further evidence for post-meiotic origin of teratomas in the human female.


Anencephalus: variation with maternal age, parity, social class and region in England, Scotland and Wales.


Pictorial representation of the distribution of the sickle-cell trait by contours drawn by a computer-controlled X-Y plotter.


Thermostability studies on the isozymes of human phosphoglucomutase.


The Ensu scoring system in genetic counselling.


The investigation of reactive sulphydryls in enzymes and their variants by starch-gel electrophoresis: studies on the human phosphohexose isomerase variant PHI5-1.


Heritability of liability and concordance in monozygous twins.


The pathology and treatment of polyps of the colon and rectum.


Problems peculiar to oral pathology.

Problems peculiar to oral pathology.


Surgery in the prevention of fatal pulmonary embolism with some observations on the morbid anatomy of veins.


Surgeon training in the United States of America.


Clinical survey of 354 patients with gout.


Arthropathy of haemochromatosis. Clinical and radiological analysis of 63 patients with iron overload.


Arthritis associated with Salmonella infections.


Osteoarthrosis of the hip joint and sexual activity.


Spontaneous rupture of the calcaneal tendon in rheumatoid arthritis after local steroid injection.


Intra-articular pressure and rheumatoid geodes (bone 'cysts').


Surgical synovectomy and experimental immune synovitis in the rabbit knee joint.


Absorption of vitamin B12 in rheumatoid arthritis.


Raised serum alkaline phosphatase in rheumatoid disease. An index of liver dysfunction?


Urinary cytology in experimental toxic renal injury.


Ulcerative colitis and sacroiliitis: a family study.


Uric acid metabolism in starvation.

Uric acid metabolism in starvation.


Some observations on culturing human cartilage and joints.


Do oral corticosteroids cause osteoporosis in rheumatoid arthritis?


Paget's disease in population samples.

Paget's disease in population samples.


Physician's assessment of functional overlay.


Observations on connective tissue tensile strength in the chick embryo.


Ochronotic densification.

Ochronotic densification.


Synovectomy of the knee in rheumatoid arthritis. I. Short-term observations.


Synovectomy of the knee in rheumatoid arthritis. II. Long-term results.


Surgical management of severe subluxations of the rheumatoid cervical spine.


Purification and amino acid sequence of melanocyte-stimulating hormone from the dogfish Squalus acanthias. A melanocyte-stimulating hormone (MSH) was isolated by gel filtration and ion-exchange chromatography from extracts of the pituitary glands of dogfish. Sequence studies were carried out on the hormone and its enzymically and chemically cleaved fragments. The sequence of the hormone, Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Met, shows that ten of its 11 residues are the same as ten of the 13 residues of mammalian alpha-MSH. About half of its molecules have the carboxyl group at the C-terminus free and about half are amidated; about a fifth have an extra tyrosine residue on the N-terminus, thereby making 11 residues the same as in mammalian alpha-MSH. Unlike the mammalian hormone, however, none of it was found to be N-acetylated.


The reversible reaction of protein amino groups with exo-cis-3,6-endoxo-delta-tetrahydrophthalic anhydride. 1. The reaction of exo-cis-3,6-endoxo-Delta(4)-tetrahydrophthalic anhydride with amino groups of model compounds and lysozyme is described. 2. Reaction with the in-amino group of N(alpha)-acetyl-l-lysine amide gives rise to two diastereoisomeric products; at acid pH the free amino group is liberated with anchimeric assistance by the neighbouring protonated carboxyl group with a half-time of 4-5h at pH3.0 and 25 degrees C. 3. The amino groups of lysozyme can be completely blocked, with total loss of enzymic activity. Dialysis at pH3.0 results in complete recovery of the native primary and tertiary structure of lysozyme and complete return of catalytic activity. 4. The specificity of reaction of this and other anhydrides with amino groups in proteins is discussed.


The mitochondrial oxidation of quinol monophosphates. 1. Mitochondria from ox heart and rat liver catalysed a slow cyanide-sensitive oxidation of 2,3-dimethylnaphthaquinol monophosphate, duroquinol monophosphate, menadiol 1-phosphate and menadiol 4-phosphate. 2. The release of P(i) was concomitant with oxygen uptake. 3. The oxidation was somewhat stimulated by Ca(2+) and P(i), and weakly inhibited by 2,4-dinitrophenol. 4. The quinol monophosphates effected a rapid reduction of free cytochrome c, and consequently addition of cytochrome c greatly increased the rate of the mitochondrial oxidation of 2,3-dimethylnaphthaquinol monophosphate. 5. This quinol phosphate interacts with the electron-transport chain at the level of cytochrome c. 6. Polylysine promoted an interaction between 2,3-dimethylnaphthaquinol monophosphate and cytochrome oxidase. Thus, although polylysine blocks mitochondrial oxidations via reduced cytochrome c, the oxidation of the quinol phosphate was strongly stimulated. 7. This stimulation was most effective in the most intact mitochondrial preparations and was inhibited by ADP and by P(i). 8. The implications of these results for factors limiting the rate of quinol phosphate oxidation, the mode of action of stimulators and the mechanism of P(i) formation are discussed.


Early steps in the biosynthesis of mycobactins P and S. 1. Lysine is readily incorporated into mycobactins P and S. Incorporation is into the hydroxamic acid moieties only and is equal in the mycobactic acid and cobactin portions of the molecule. 2. 2-Amino-6-hydroxyaminohexanoic acid is not taken up by cells of Mycobacterium phlei and is not detectable in extracts of cells actively synthesizing mycobactin. 3. The most abundant material derived from lysine that can be detected in such cell extracts is an N(6)-acyl-lysine. Cells grown in the presence of iron contain markedly less of this material than do those grown under conditions of iron deficiency. 4. When added to growing cultures of M. phlei the N(6)-acyl-lysine is readily incorporated into mycobactin. 5. The hydroxy acid of cobactin P is derivable from propionate.


Secretion of cell-wall glycoproteins by yeast protoplasts. Effect of 2-deoxy-D-glucose and cycloheximide. The effect of 2-deoxy-d-glucose and cycloheximide on the synthesis and secretion of the cell-wall constituents protein and mannan in yeast protoplasts was examined in detail. Although the 2-deoxy-d-glucose hardly influenced protein synthesis, a significant parallel inhibition of carbohydrate and protein secretion into the medium was observed. The mechanism of this inhibition is considered as an interference of metabolites of 2-deoxy-d-glucose with the synthesis of yeast mannan. Cycloheximide, which is an effective inhibitor of protein synthesis in yeast (Kerridge, 1958), inhibited the secretion of non-diffusible carbohydrate in yeast protoplasts, but on the other hand had no effect on the activity of particulate yeast mannan synthetase. Our results clearly show that blocking the synthesis of either part of the mannan-protein complex prevents the extracellular appearance of the other component. The nature of this phenomenon is discussed.


Formation of mercapturic acids in rats after the administration of aralkyl esters. 1. Benzylmercapturic acid and hippuric acid were isolated from the urine of rats that had been injected subcutaneously with benzyl acetate. 2. 1-Menaphthylmercapturic acid and 1-naphthoic acid were isolated from the urine of rats after the subcutaneous injection of each of the following compounds: 1-menaphthyl alcohol and its acetate, propionate, butyrate and benzoate esters. 3. A quantitative method for determining 1-menaphthylmercapturic acid in urine was developed and used to measure the excretion of this compound in the urine of rats in the 4-day period after the subcutaneous injection of 1-menaphthyl alcohol and its acetate, propionate, butyrate and benzoate esters. 4. Chromatographic evidence was obtained for the presence of S-(1-menaphthyl)glutathione and S-(1-menaphthyl)-l-cysteine in bile collected from rats with cannulated bile ducts after the animals had been injected subcutaneously with each of the following compounds: S-(1-menaphthyl)glutathione, 1-menaphthyl acetate, propionate and butyrate. 5. Benzylmercapturic acid and 1-menaphthylmercapturic acid were isolated from the urine of rats that had been injected with sodium benzyl sulphate and sodium 1-menaphthyl sulphate respectively.


The effect of electrical stimulation and ouabain on the uptake and efflux of L-[U-14C] valine in chopped tissue from guinea-pig cerebral cortex. 1. Chopped tissue from guinea-pig cerebral cortex carried out an energy-dependent accumulation of l-[(14)C]valine. 2. The uptake was dependent on the extracellular concentration of Na(+) and was markedly inhibited by ouabain (20mum). The extent of the inhibition of uptake by ouabain was also Na(+)-dependent. 3. The accumulation of labelled valine was not directly dependent on the ATP and creatine phosphate contents of the slices. 4. Electrical stimulation increased the rate of [(14)C]valine uptake at first but ultimately led to a net loss of the label so that the amount of label present in the tissue was lower than in the controls. 5. The rate of loss of label during prolonged stimulation was dependent on the extracellular concentration of Na(+). 6. The efflux of labelled valine from slices preloaded at 164mm-Na(+) was studied at 164, 80 and 40mm-Na(+) with and without electrical stimulation or ouabain. 7. Lowering the Na(+) concentration or adding ouabain increased the rate of efflux. 8. Electrical stimulation had little effect on the rate of efflux at first but ultimately led to a more complete loss of label from the tissue than occurred in the control. A kinetic analysis of the efflux curves was attempted.


The effect of electrical stimulation on the incorporation of L-[U-14C] valine into the protein of chopped tissue from guinea-pig cerebral cortex. 1. Chopped tissue from guinea-pig cerebral cortex carried out an energy-dependent incorporation of [(14)C]valine into protein. 2. At all times studied the nuclear fraction of the homogenized tissue accounted for about 25% of the total labelled protein. 3. Electrical stimulation at first increased, but subsequently decreased, the rate of incorporation of [(14)C]valine into protein of the chopped tissue. 4. The initial increase in the incorporation of [(14)C]valine into protein occurred in the nuclear fraction. At later times electrical stimulation decreased the incorporation into all the subcellular fractions, but the relative contribution of the nuclear fraction to the total labelled protein increased. 5. These changes are discussed in relation to the changes in the rates of respiration, glycolysis, high-energy phosphate content and intracellular Na(+) and K(+) concentrations, which were measured under the same experimental conditions as those used to study protein synthesis.


Determination of the kinetic constants of two consecutive first-order reactions.


The effect of preganglionic stimulation on the incorporation of L-[U-14C] valine into the protein of the superior cervical ganglion of the guinea pig. 1. Superior cervical ganglia from the guinea pig carry out an energy-dependent incorporation of l-[(14)C]valine into protein in vitro. 2. Stimulation of the preganglionic nerve at a physiological frequency for more than a few minutes decreases the ability of the ganglia to incorporate labelled valine into protein.


Glycine decarboxylase in Rhodopseudomonas spheroides and in rat liver mitochondria. 1. Glycine decarboxylase and glycine-bicarbonate exchange activities were detected in extracts of Rhodopseudomonas spheroides and in rat liver mitochondria and their properties were studied. 2. The glycine decarboxylase activity from both sources is stimulated when glyoxylate is added to the assay system. 3. Several proteins participate in these reactions and a heat-stable low-molecular-weight protein was purified from both sources. 4. These enzyme activities increase markedly when R. spheroides is grown in the presence of glycine, glyoxylate, glycollate, oxalate or serine. 5. All the enzymes required to catalyse the conversion of glycine into acetyl-CoA via serine and pyruvate were detected in extracts of R. spheroides; of these glycine decarboxylase has the lowest activity. 6. The increase in the activity of glycine decarboxylase on illumination of R. spheroides in a medium containing glycine, and the greater increase when ATP is also present in the medium, probably accounts for the increased incorporation of the methylene carbon atom of glycine into fatty acids found previously under these conditions (Gajdos, Gajdos-Török, Gorchein, Neuberger & Tait, 1968). 7. The results are compared with those obtained by other workers on the glycine decarboxylase and glycine-bicarbonate exchange activities in other systems.


Nucleotide 'maps' of digests of deoxyribonucleic acid. Various digests of (32)P-labelled DNA were examined by two-dimensional ionophoresis on cellulose acetate and DEAE-cellulose paper. The products from digestion with pancreatic deoxyribonuclease and Neurospora crassa endonuclease were qualitatively closely similar, but very complex, and were used to investigate the mapping behaviour of nucleotides in various ionophoretic systems. Ionophoresis on DEAE-cellulose paper in triethylamine carbonate, pH 9.7, followed by ionophoresis in the second dimension at pH1.9 gave high resolution of nucleotides in very complex mixtures and permitted the fractionation of larger quantities than is possible on cellulose acetate. High resolution of nucleotides in compact spots was obtained with two-dimensional ionophoresis on cellulose acetate and AE-cellulose paper, a system that is a useful supplement to those based on DEAE-cellulose paper.


Acid-soluble phosphorus compounds in mammalian semen. 1. A method is described for the extraction, purification and separation of acid-soluble phosphorus compounds from mammalian semen. [8-(14)C]ATP and [8-(14)C]AMP were used as internal recovery standards to measure the breakdown and loss of these nucleotides in the procedure. 2. Bull, ram, boar and stallion semen was separated into seminal plasma and spermatozoa and the two fractions were examined separately. The overall composition of the mixture of the phosphorus compounds extracted from the two fractions was similar for the four species. 3. Glycerylphosphorylcholine and glycerylphosphorylinositol were the two phosphorus compounds identified in extracts of seminal plasma. ATP, ADP, AMP, GTP, GDP, NAD, fructose 1,6-diphosphate and glucose 6-phosphate were identified in extracts prepared from spermatozoa.


Structural requirements for active intestinal transport. The nature of the carrier-sugar bonding at C-2 and the ring oxygen of the sugar. Several weakly transported sugars were tested for transport by the Na(+)-dependent sugar carrier with slices of everted hamster intestinal tissue. Sugars were assumed to be transported by this carrier if the accumulation was diminished in the absence of Na(+) and in the presence of the competitive inhibitor 1,5-anhydro-d-glucitol. The extent of accumulation was correlated with the number of hydroxyl groups in the d-gluco configuration if the ring oxygen was placed in the normal d-glucose position. 5-Thio-d-glucose, with a sulphur atom in the ring, was transported at about the same rate as d-glucose and had a similar K(i) for d-galactose transport, but myoinositol was poorly accumulated. It is suggested that there is no hydrogen bonding at the ring oxygen atom, but that the oxygen atom is found at this position as a result of steric constraints. No sugar without a hydroxyl group in the d-gluco position at C-2 of the sugar, including d-mannose, 2-deoxy-d-glucose, 2-chloro-2-deoxy-d-glucose and 2-deoxy-2-fluoro-d-glucose, was transported by the Na(+)-dependent carrier, but these sugars and l-fucose weakly and competitively inhibit the Na(+)-dependent accumulation of l-glucose into slices of everted hamster intestinal tissue. It is concluded that the bond between the carrier and C-2 of the sugar may be covalent, and a possible mechanism for active intestinal transport is proposed.


Human serum protein fractionation by gel filtration. The development of a quantitative immunological technique using polyvalent antiserum permits a more logical approach to the fractionation of complex protein mixtures. In this study whole serum was separated by conventional gel filtration and the fractions obtained were analysed. This demonstrates over 60 immunologically distinct serum proteins. Because the current terminology is inadequate to describe this number of proteins, a temporary numerical nomenclature has been used.


Ultrastructural studies on mitochondrial swelling. Mitochondrial swelling induced by valinomycin, calcium chloride and P(i) was studied after potassium permanganate fixation in suspension. Valinomycin induces a rapid K(+) influx, increase of the matrix space and out-folding of the cristae, with good preservation of the matrix material. This swelling is reversible but the cristae do not completely re-form and have a blebbed appearance. On repeated swelling and contraction cycles there is a gradual loss of matrix material. Calcium chloride and P(i) produce a slow swelling of the matrix space. Shrinkage induced by ATP was partial and not associated with return to the original structure.


Analytical study of the degradation of nucleohistone during calf thymus chromatin autolysis. The mechanism of nucleohistone degradation in calf thymus chromatin during autolysis of the latter involves a release of lysine-rich histone fractions, followed by degradation of the thus-exposed DNA portions; the latter portions are richest in adenine-thymine sequences. After this degradation process, residual nucleohistone fragments of low molecular weight (10(5)) remain. Their chemical composition is special, in that the DNA contains a larger proportion of guanine-cytosine sequences than does the initial DNA and it is combined with arginine-rich histones.


The Meyerhof quotient and the synthesis of glycogen from lactate in frog and rabbit muscle. 1. The conversion of lactate into glycogen was demonstrated in frog sartorius muscle in oxygen. The rates and amounts are highest when lactate is added to the bathing medium and are dependent on lactate and CO(2) concentration, as well as pH. The glycogen content of a resting muscle can be doubled in 4h at 24 degrees C. 2. Sartorius muscle, recovering aerobically in liquid paraffin from a period of anoxia, converts preformed lactate into glycogen at a lower rate and in smaller amounts than when lactate is added in an aqueous medium. The lower rates are similar to those Meyerhof found under the same conditions, after correction for temperature; they can be attributed partly to low muscle pH and partly to the limited amounts of lactate present. 3. Rabbit psoas muscle also shows the ability to convert added lactate into glycogen under aerobic conditions. The rates are low and similar to those in frog sartorius muscle recovering from anoxia. 4. The present experiments yield a Meyerhof quotient of 6.2, compared with Meyerhof's value of 4-5. However, these values are not significantly different from one another. 5. It is suggested that the glycogen coefficient, i.e. mol of glycogen formed/mol of lactate disappearing, is a more reliable way of assessing the resynthetic mechanism than the original quotient, i.e. mol of lactate disappearing/mol of lactate oxidized. The found coefficient is 0.419+/-0.024.


Resistance of extracellular yeast invertase and other glycoproteins to denaturation by tannins.


Metabolism of pyrrolidonecarboxylic acid in the rat.


Alkylation of bovine brain creatine kinase.


Investigations into the metabolism in vitro of C19 steroids by the sheep placenta.


Digital fibrous swellings in children.

Digital fibrous swellings in children.


Variations in the levels of cholesterol and triglyceride in the skin surface fat during the menstrual cycle.


The influence of age, sex, hypophysectomy and various hormones on the composition of the skin surface lipids of the rat. Hormones and sebum composition in the rat.


Apocrine sweat gland carcinoma. Report of a case.


The medical exhibition.

The medical exhibition.


Symposium on intensive care and therapy. Introduction.


Film in dermatology.

Film in dermatology.


The management of pain in the intensive care unit.


Intensive-care-metabolic response to injury.


Management problems in intensive care units.


Symposium on intensive care and  therapy. Concluding remarks.


The early diagnosis of deep-vein thrombosis by ultrasound.


Tape-closed and sutured wounds: a comparison by tensiometry and scanning electron microscopy.


Pyloric stenosis and paradoxical acid urine: an experimental study in dogs.


Release of prostaglandins from embolized lungs.


Gastric incontinence and post-vagotomy diarrhoea.


Reticulo-endothelial activity in humans with cancer.


Organization of accident services.

Organization of accident services.


Haemodynamic studies in peripheral arterial disease.


The outcome in 455 patients admitted for treatment of diverticular disease of the colon.


Massive pulmonary embolism: what can be done to improve survival?


Symposium: what's new in the treatment of peptic ulcer? Introduction.


The comparative results of different operations in the elective treatment of duodenal ulcer.


Surgical treatment of gastric ulcers. Controlled comparison of Billroth-I gastrectomy and vagotomy and pyloroplasty.


The fine structure of the subnucleus caudalis of the trigeminal nerve.


The management of side-effects of surgery for peptic ulceration.


The organization of primary afferents in the subnucleus caudalis of the trigeminal: a light and electron microscopic study of degeneration.


Regional changes in amino acid concentration in the developing brain and the effects of neonatal administration of estradiol.


Reticular projections to lateral geniculate in cat.


Area postrema: abrupt EEG synchronization following close intra-arterial perfusion with serotonin.


Symmetrical axo-axonic synapses in the axon cap of the goldfish Mauthner cell.


Organization of lateral geniculate neurons in binocular inhibition.


Brain temperature and the cerebral circulation in the chicken.


Mapping the cord of the spinal cat for sympathetic and blood pressure responses.


Effect of crossed-perfusion of the midbrain reticular formation upon sleep.


Sodium and potassium content of normal and neoplastic rodent astrocytes in cell culture.


Natural electrical activity in mammalian parasympathetic ganglion neurones.


Lactate dehydrogenase isozyme pattern contained in neurons resolved by microdisc electrophoresis.


Potassium and glutamate effects on protein synthesis in isolated neuroglial cells.


Effects of atropine on chemoreceptor discharges in the carotid body of the cat.


Ion transport across the frog posterior choroid plexus.


The influence of age on the behaviour of carcinoma of the breast. A consecutive series of 1530 patients with carcinoma of the breast has been reviewed to study the influence of age and marital status on the disease.The risk of developing breast cancer increases with age, though a peak may be reached at 75 years. The risk of developing a tumour of advanced clinical stage at presentation apparently increases with age. Local recurrence rates and mortality rates are similar at all ages. It is concluded that the therapy required is similar in all age groups.The increased risk of developing breast cancer in "never married" women is in the postmenopausal period. Survival rates and the distribution of the various presenting clinical stages are similar in both single and married patients.Though ageing and marital status have an initiating effect on breast cancer, they do not have a continuing effect on the established disease.


Diabetes in the aged: underdiagnosis and overtreatment. In keeping with the already known high prevalence of diabetes among residents of the Jewish Home for the Aged, Toronto, annual screening disclosed an average incidence of 25.5% of abnormal glucose tolerance (two-hour post-glucose blood sugars above 140 mg./100 ml.) in residents not known to be diabetic.Forty-five (47%) of the 94 residents with abnormal screening values were considered subsequently to be diabetic according to our criteria.Long-term follow-up, particularly of 81 residents initially normoglycemic in 1964-5, confirmed that the natural course of glucose tolerance in this population was one of progressive deterioration.By contrast, improvement amounting to remission has been demonstrated in nine out of 20 residents several years after they had been declared diabetic, and is thought to have been induced by dietotherapy.Moderate hyperglycemia per se did not cause symptoms in these almost always keto-resistant and usually aglycosuric aged diabetics, who often claimed they felt better when hyperglycemic. Hypoglycemia was an ever present danger when anti-diabetic medication was used; it was the main reason for undertreatment.So far, data from our long-term study have not shown morbidity to be markedly increased in the diabetics, and mortality was found to be evenly distributed among diabetic and non-diabetic male residents. However, in the females there was a clear correlation between mortality rate and the diminished glucose tolerance.What may appear as overdiagnosis of diabetes in the aged is recommended in the hope that early institution of dietary treatment will delay the development of clinical diabetes and the need for anti-diabetic agents. This, in turn, would prevent iatrogenic hypoglycemia. It would also reduce the severity and frequency of spontaneous hypoglycemia which, we believe, occurs more commonly in the early phase of diabetes in the aged than is generally realized.


Studies of male survivors of myocardial infarction. XII. Relation of serum lipids and lipoproteins to survival over a 10-year period. The relation of serum cholesterol and standard S(t) lipoproteins to survival over a 10-year period was studied in a "good risk" group of 120 men, aged 31 to 83, who had survived myocardial infarction by at least three months. All subjects were free of other disorders that might affect survival and were not receiving therapy to alter their serum lipids.Ten-year survival from time of entry into the study was 35%. Age had no important influence on survival. Neither the level of the serum cholesterol nor of the lipoprotein fractions related to survival. Mode of coronary death, whether infarctional or sudden, was also unrelated to serum cholesterol.Although the incidence and age of onset of CHD is influenced by serum lipid levels, survival subsequent to infarction is not. Apparently serum lipids affect the rate of atherogenesis in the long silent preclinical stage, but in the short clinical stage other factors determine survival. This suggests that therapy to lower serum lipids, based on a specific diagnosis of the type of hyperlipoproteinemia, should be started early in life before clinical disease occurs.


Preventive medicine and family medicine in the medical school.


Acute subluxation of the cervical spine (Case P49).


A case of malignant hyperpyrexia.

A case of malignant hyperpyrexia.


Epitheloid sarcoma. A sarcoma simulating a granuloma or a carcinoma.


Papillary carcinoma of the thyroid. I. Developing pattern of metastasis.


Papillary carcinoma of the thyroid. II. Value of prophylactic lymph node excision.


Embryonal adenocarcinoma in the prepubertal testis. A clinicopathologic study of 18 cases.


Langerhans cell granulein Letterer-Siwe disease. An electron microscopic study.


Retroperitoneal xanthogranulomas. Case report of favorable response following irradiation.


Adenocarcinoma of the small bowel complicating Crohn's disease.


Papillary epithelial neoplasm of pancreas in a child. Report of a case with electron microscopy.


The mode of spread of Hodgkin's disease to the skin.


Endometrioid carcinoma of the ovary. A clinicopathologic study of 75 cases.


Thermography in detection of early breast cancer.


Ultrastructure of a fibromatosis hyalinica multiplex juvenilis.


The histopathology of bronchogenic carcinoma and its relation to growth rate, metastasis, and prognosis.


T N M classification for stomach cancer.


The radiological appearances in allergic broncho-pulmonary aspergillosis.


Polyps and carcinoma of the large bowel in the South African Bantu.


Sarcoidosis. Typical and atypical thoracic manifestations and complications.


Accidental injection of dionosil into the neck during bronchography.


Hytrast: experimental bronchography comparing two different formulations.


Gamma densitometry in the study of ventilation and the pulmonary circulation.


A radiological assessment of the oropharynx with special reference to tomography.


The accessory middle cerebral artery: report of further two cases.


Laparotomy and splenectomy as routine investigations in the staging of Hodgkin's disease before treatment.


The potassium-sensitivity of isolated embryonic heart cells increases with development.


Ultrastructure of developing melanosomes in C57 black and pallid mice.


Epithelial-mesenchymal interactions during odontogenesis. I. Isolation of several intercellular matrix low molecular weight methylated RNAs.


The physiological effects of hypoxia on the erythrocytes of the chick embryo.


Spontaneous reduction of transplantability in cultured mammary carcinoma cells.


Localization of radioiodinated fibrinogen in invaded and metastasized tumor tissue of Walker carcinosarcoma.


Elimination, tissue accumulation, and metabolic fate of 4-nitroquinoline 1-oxide administered orally in rats.


Gastric carcinoma in a fixed population: Hiroshima and Nagasaki.


Effect of carbazilquinone on lymphoid leukemia L-1210.


Effect of toxohormone on serum iron in mice.


Inhibition of L cell adenine phosphoribosyltransferase by nucleosides and nucleotides.


Vi haemagglutination test for the identification of typhoid carriers.


The influence of urea on the growth of Proteus mirabilis.


The effect of borate on polysaccharide-protein and antigen-antibody reactions and its use for the purification and fractionation of crossreacting antibodies.


Detection of natural IgM subunits and subunits of IgM produced by reduction and alkylation by anti-mu sera.


The synaptology of the granule cells of the olfactory bulb.


An electron-microscopic study of the termination of the afferent fibres to the olfactory bulb from the cerebral hemisphere.


Species specificity of an enzyme determined by an erythrocyte nucleus in an interspecific hybrid cell.


The question of relationship between Golgi vesicles and synaptic vesicles in Octopus neurons.


A note on synaptic structure of the retina of Octopus vulgaris.


The fine structure of obliquely striated body wall muscles in the earthworm, Lumbricus terrestris Linn.


Neuromuscular junctions in the body wall muscles of the earthworm, Lumbricus terrestris Linn.


Lateral fusion of membranes in bacteroid-containing cells of leguminous root nodules.


Electron-microscope observations on the structure of condensed chromatin: evidence for orderly arrays of unit threads on the surface of chicken erythrocyte nuclei.


The fine structure of meiotic chromosome pairing in natural and artificial Lilium polyploids.


The concentrations of water, sodium and potassium in the nucleus and cytoplasm of amphibian oocytes.


The morphology of the granule cells of the olfactory bulb.


Megaloblastic anaemia of pregnancy: a clinical and laboratory study with particular reference to the total and labile serum folate levels. It has been shown that the incidence of megaloblastic anaemia in a group of 463 randomly selected pregnant women receiving iron was 12 times as high as in a control group of 235 pregnant women receiving iron and folic acid. The incidence of all types of anaemia in the women receiving iron alone was more than three times the incidence in those having iron and folic acid. Some women who were not anaemic or who had normoblastic anaemia had serum folate levels in the same range as the women with megaloblastic anaemia, but none of the women with megaloblastic anaemia had high serum folate levels. The labile fraction of the serum folate was no more reliable than the total serum folate as a diagnostic criterion of megaloblastic erythropoiesis in the individual case. The blood group distribution in the women with megaloblastic anaemia was the same as in the general population. Babies born to mothers with megaloblastic anaemia tended to be smaller than the rest, although there was no difference in the placental weights. The significance of these findings is discussed.


Red cell survival in biliary cirrhosis.

Red cell survival in biliary cirrhosis. Studies were carried out on eight patients with primary biliary cirrhosis. Four patients were found to have a haemolytic anaemia; one had Coombs red cell antibodies. Two patients had evidence of splenic sequestration of red cells using the radio-chromium technique. There was a significant correlation between the red cell survival and the bromsulphthalein retention test and the red cell survival and the serum level of bilirubin. It was concluded that the anaemia of cirrhosis of the liver, including primary biliary cirrhosis, may be due to a number of mechanisms and a unifying hypothesis based on the degree of liver dysfunction is suggested.


Relationships between platelet function tests in normal and uraemic subjects. IN TESTS OF PLATELET FUNCTION IN NORMAL SUBJECTS, THE FOLLOWING RELATIONSHIPS WERE FOUND: the greater the platelet adhesiveness the less the ability to disaggregate after challenge with adenosine diphosphate (ADP), and the greater the disaggregation after ADP, the longer the clotting time in the test for platelet factor 3 availability. Such correlations were disturbed in uraemic patients.


Sensitivity of Nocardia to trimethoprim and sulphonamides in vitro. Studies in vitro of the sensitivity to trimethoprim and sulphonamides of nine strains of N. asteroides, two strains of N. caviae, and one of N. blackwellii are presented. No unequivocal evidence of synergism was found. Despite this, the inclusion of trimethoprim in the drug regime when sulphonamides are used in the treatment of nocardiosis is suggested on empirical grounds.


Barbiturate blood levels found at necropsy in proven cases of acute barbiturate poisoning. In order to determine whether blood barbiturate levels could be used to ascertain that death had been caused by barbiturate overdose, samples of blood from 128 subjects of coroners' necropsies were examined for barbiturate content. Sixty of these were well authenticated cases of barbiturate overdosage, and barbiturates were implicated, together with other factors such as alcohol and carbon monoxide, in a further 16 cases. The remaining 52 cases were of an eliminatory nature, 10 of which had low barbiturate blood levels considered to be within the therapeutic range.The results indicate that when the accepted levels producing loss of consciousness are exceeded, and maintained, death will ensue if treatment is not given. These results may be of value in assessing findings in necropsies requested by the coroner, and are in no way applicable to the living patient in whom it is well established that recovery from higher blood levels may take place if adequate treatment is available.


Noise levels in a clinical chemistry laboratory. An investigation into the noise levels in a clinical chemistry laboratory has been carried out. It was shown that although the levels were insufficient to cause damage to hearing, they exceeded the criteria of acceptability for offices and workshops.


Flexible electrophoresis applicator for use with the AutoAnalyzer in routine protein analysis.


A simple high-speed recording colorimeter system.


Differentiating neoplasms of hair germ.

Differentiating neoplasms of hair germ. Differentiating neoplasms of hair germ are benign epithelial-mesenchymal tumours of skin in which hair follicle development may be partly or completely recapitulated. The epithelial component is equivalent to the hair germ. The mesenchymal component is equivalent to the dermal papilla. Epithelial-mesenchymal interaction results in the morphogenesis of hair follicles. In neoplasms showing stromal induction, there is centrifugal organizations: hair bulbs are found at the periphery of tumour lobules and hairs are projected centrally to lie within small keratinizing cysts. Neoplasms of hair germ without advanced morpho-differentiation are termed ;trichoblastomas', and those neoplasms in which hair follicle development is advanced are called ;trichogenic trichoblastomas'.


Tubular metaplasia in Bowman's capsule.

Tubular metaplasia in Bowman's capsule. Proximal tubular type metaplasia of the epithelium of Bowman's capsule is described in a fit young adult male. This form of metaplasia is unlike those previously described and could cause initial confusion if encountered in a percutaneous renal biopsy.


Fucidin in patients on haemodialysis.

Fucidin in patients on haemodialysis. Fucidin is useful against ;antibiotic-resistant staphylococci' which are a major problem in causing shunt site infections in patients on chronic intermittent haemodialysis for end-stage renal failure. A new form of intravenous fucidin has been used in vivo in three patients on haemodialysis, and also in experiments in vitro in order to assess its dialysing properties. The experiments in vitro show that some fucidin does cross the dialyser membrane but, in the patients studied, adequate serum levels were maintained throughout a 10-hour haemodialysis. A single intravenous dose of Fucidin is, therefore, adequate for treating ;antibiotic-resistant' staphylococcal infections in patients during haemodialysis.


An evaluation of the automated assay of urinary oestrogens in pregnant women. An automated assay suitable for estimating urinary oestrogens in pregnant women has been investigated. Fluorimetry was found to have considerable advantages over colorimetry. The fluorimetric assay was simpler, more precise, more sensitive, and eliminated the need for correction for non-specific chromogens; in the assay of oestriol in pregnant women there was no need for correction for non-specific fluorescence. Spectrofluorimetric and photometric analyses, recoveries, and reproducibility show that the method offers a robust means of providing values for urinary oestrogen in pregnant women on a scale of up to 100 tests a day, the time of the assay being one and a half hours.


Electrophoretic separation of tissue-specific serum alkaline phosphatases. Previous electrophoretic methods for the separation of tissue-specific serum alkaline phosphatases have either been unable to separate the liver and bone enzymes or have been too involved for routine clinical use. A relatively simple electrophoretic method is described which separates placental, liver, bone, and intestinal alkaline phosphatases in serum. The clinical applications of such a method appear to be mainly in the differential diagnosis of liver and bone disease, especially in complicated hypercalcaemic states where tumour metastases can affect both bone and liver, in children, and possibly in cirrhosis of the liver.No differences in electrophoretic mobility could be seen between zymograms of different diseases affecting the same organ. Patients presenting with hepatic cirrhosis all showed a marked serum intestinal alkaline phosphatase zone as well as a liver zone on electrophoresis. An intestinal zone was not present with other types of hepatobiliary disease.The heterogeneity of total serum alkaline phosphatase activity in normal subjects is demonstrated, alkaline phosphatases of liver and bone, and sometimes of intestine being present in normal serum. Results obtained in women in the last trimester of pregnancy and in old people are also discussed.