Stochastic properties of discrete waves of the limulus photoreceptor. In the dark-adapted photoreceptor of the horseshoe crab, Limulus, transient discrete depolarizations of the cell membrane, discrete waves, occur in total darkness and their rate of occurrence is increased by illumination. The individual latencies of the discrete waves evoked by a light stimulus often cannot be resolved because the discrete waves overlap in time. The latency of the first discrete wave that follows a stimulus can be determined with reasonable accuracy. We propose a model which allows us to make an estimate of the distribution of the latencies of the individual light-evoked discrete waves, and to predict the latency distribution of the first discrete wave that follows a stimulus of arbitrary intensity-time course from the latency distribution of the first discrete wave that follows a brief flash of light. For low intensity stimuli, the predictions agree well with the observations. We define a response as the occurrence of one or more discrete waves following a stimulus. The distribution of the peak amplitudes of responses suggests that the peak amplitude of individual discrete waves sometimes has a bimodal distribution. The latencies of the two types of discrete waves, however, follow similar distributions. The area under the voltage-time curve of responses that follow equal energy long (1.25 sec) and short (10 msec) light stimuli follows similar distributions, and this suggests that discrete waves summate linearly.


The effects of amino acids on the labellar hair chemosensory cells of the fly. The effects of amino acids on the labellar hair chemosensory cells were examined with two kinds of flies (the fleshfly, Boettcherisca peregrina, and the blowfly, Phormia regina). As a result of this examination, the effects of amino acids were divided into four main classes. Amino acids in class 1 did not stimulate any chemoreceptor cell. Amino acids in class 2 inhibited nonspecifically the discharges from three kinds of chemosensory cells. Amino acids in class 3 stimulated the salt receptor cell. Amino acids in class 4 stimulated the sugar receptor cell. A possibility that a fourth neuron in the labellar hair chemosensory cell might be a protein or an amino acid receptor cell was eliminated.


An educational program for primary care.


Introducing a sex education course into the medical curriculum.


The training and practice of women physicians: a case study.


Twelve years' experience with a comprehensive ambulatory care program.


Providing medical information to physicians by telephone tapes.


The academic health center and health care delivery. 3. The changing scene.


Application activity and MCAT data of applicants to the class of 1969-70.


Medical school organization: a new approach.


The academic health center and health care delivery. The changing scene. I.


Impact of medical school characteristics on location of physician practice.


The academic health center and health care delivery. The changing scene. II.


Chick lens differentiation in vitro.

Chick lens differentiation in vitro.


The academic health center and health care delivery. Preparing personnel to meet the demand.


A histochemical study of the circumtesticular Leydig cells of a teiid lizard, Cnemidophorus tigris.


The segmental origin of the appendages of the head and anterior body segments of a spiroboloid milliped, Narceus annularis.


Sense organs of a thysanuran, Ctenolepisma lineata pilifera, with special reference to those on the antennal flagellum (Thysanura, Lepismatidae).


Morphogenesis of albino rat lung: an autoradiographic analysis of the embryological origin of the type I and II pulmonary epithelial cells.


Comparison between electroencephalographic and systematic nursing observations of sleep in psychiatric patients.


Dreams and suicide attempts.

Dreams and suicide attempts.


Telepathy and dreams: a controlled experiment with electroencephalogram-electro-oculogram monitoring.


Optokinetic nystagmus as a criterion of visual imagery.


The electromyographic study of verval hallucination.


Prediction of lightness and brightness on different backgrounds.


Perception of white in a 10 degree field.


Subjective measurement of accommodation with laser light.


Experimental Leucothoe grayana poisoning in goats.


Hydrofluoric acid treatment on pasture grass ashes for atomic absorption analysis.


Influence of congenital passive immunity on the response of chicks to Newcastle disease vaccination.


Rabbit antibody light chains and gene evolution.


Variability in the lambda light chain sequences of mouse antibody.


Reactivity of inbred mouse sera with antisera to the variable region of light chains.


Origin of mammalian trypanosomes which develop in the anterior-station of blood-sucking arthropods.


Mechanism for joining V and C genes.

Mechanism for joining V and C genes.


Cyclophosphamide tolerance as a test for antigenicity of nucleic acids.


IgG synthesis in hybrid cells from an antibody-producing mouse myeloma and an L cell substrain.


Long range coherence and the action of enzymes.


GM1-gangliosidosis types 1 and 2: enzymatic differences in cultured fibroblasts.


Inhibition of chemical carcinogenesis in the hamster cheek pouch by topical chlorpromazine.


Metabolism of D-alanine in Rhodospirillum rubrum and its bacilliform mutants.


Effect of salts and pH on fish chemoreceptor responses.


Effect of Ca2+ on the water and non-electrolyte permeability of phospholipid membranes.


Unusually high taste acuity for phenylthiocarbamide in two Formosan aboriginal groups.


Temporal bounds of post-ingestive glucose induced satiety in man.


Lack of a long-term effect of LSD on Y-maze learning in mice.


Inhibitory action of the amygdala on the lateral hypothalamic area in rats.


Alpha rhythm and fine eye and eyelid movement.


How dependable are skin tests?

How dependable are skin tests?


Pages from an allergist's notebook. Some problems of everyday practice.


The challenge of our time.

The challenge of our time.


Why did we destroy Europe?

Why did we destroy Europe?


Contributions of the Frensham group.

Contributions of the Frensham group.


Some implications of the scientiae for the future of mankind.


The code of science. Analysis and some reflections on its future.


The enmity between generations and its probable ethological causes.


Critical aspects of the future of the human species.


The identification and divison of the bundle of Kent for premature ventricular excitation and supraventricular tachycardia.


In vivo cinephotographic analysis of the hydrodynamics of prosthetic cardiac valves.


The late results of axillofemoral grafts.


The use of small-diameter Dacron grafts with wall-bonded heparin for venous and arterial replacement: canine studies and preliminary clinical experience.


Treatment of infected aortofemoral arterial prosthesis.


Experiences with modified bovine carotid arteries in arterial surgery.


Pulsatile cardiopulmonary bypass: clinical evaluation.


A liquid-liquid oxygenator utilizing oxygen-saturated inert fluorocarbon for organ perfusion-preservation.


Cholesterol reduction by partial ileal bypass in a pediatric population.


A new absorbable synthetic suture in growing and adult primary vascular anastomoses: morphologic study.


Hypothenar hammer syndrome: posttraumatic digital ischemia.


Risk of excision of abdominal aortic aneurysms.


Popliteal aneurysms.

Popliteal aneurysms.


New techniques in the treatment of extensive fibromuscular disease involving the renal arteries.


The influence of femoral vein dynamics on the development of varicose veins.


Arterial emboli: an analysis of 125 patients.


Leiobunum longipes: radioautographic localization of 5-hydroxytryptamine.


The late results of caval ligation.

The late results of caval ligation.


A removable intracaval filter for prevention of pulmonary embolism: early experience with the use of the Eichelter catheter in patients.


Corpus cardiacum: induced fluctuation in paraldehyde-fuchsin material in Aedes sollicitans.


Chlamydotheca arcuata: autoradiographic localization of 14C-Aldrin and 14C-Dieldrin.


Immunologic assay for factors controlling granulopoesis in rat bone marrow: maturation factor from rat serum.


A differential extraction method for the isolation of host nucleic acids from TMV-infected tobacco plants.


On the mechanism of persistence and distribution of barley yellow dwarf virus in an aphid vector.


Studies on the structural polarity of bacteriophage f1.


Properties of infectious ribonucleic acid from wheat streak mosaic virus.


Determination of molecular weights of plant viral protein subunits by polyacrylamide gel electrophoresis.


The size of the rII region of bacteriophage T4.


Electron microscopy on the behavior of two strains of alfalfa mosaic virus in mixed infections.


Vision and visual pigments in a fish, Scardinius erythrophthalmus (the rudd).


Landolt's club in the retina of the African lungfish, Protopterus aethiopicus, Heckel.


Interaction of excitation and inhibition in the stirnorgan of the frog.


Rod participation in the 'blue' mechanism and its effect on colour matching.


Induced changes in the perceived orientation of line segments.


Insulin participation in the plasma inorganic phosphorus decrease induced by 2-deoxy-D-glucose.


Treatment of diabetic retinopathy.

Treatment of diabetic retinopathy.


The car and the cardiac.

The car and the cardiac.


Roentgenographic findings of perinephric abscess.


Diagnosis and treatment of groin eruptions.


Acute head injuries.

Acute head injuries.


International Academy of Proctology Congress, German Session. Introduction.


Statistics of ulcerative colitis. A catamnestic study of 229 patients.


Ulcerative colitis. Etiologic unity or polyetiologic syndrome?


Vitamin absorption in the colon.

Vitamin absorption in the colon.


Enzyme cytochemical and isoenzyme studies of normal and diseased rectal mucosa.


The problem of continence. Following pediatric operations in the anal and rectal area.


Sympathetic control of synovial blood vessels.


Hygroma. A histological review.

Hygroma. A histological review.


The technetium scintigram as an indicator of syovial vascularity in rheumatoid arthritis: its comparison with the results of temperature measurement.


Stenosis of the lumbar spinal canal and sciatic claudication. A study of 29 cases, thirteen of which were operated upon.


Studies on immunization of golden hamsters to transplantable melanomas.


Growth in vitro of L-1210 leukemia in suspension culture.


A technique for removing a broken ureteric catheter from a child's bladder.


Clindamycin in the treatment of minor surgical infections.


Perforation of the colon due to carcinoma.


Panhypopituitarism, chronic renal failure and osteomalacia.


Cardiac tamponade due to massive pericardial effusion in myxoedema.


Two cases of lupus erythematosus profundus.


Profession or technocracy.

Profession or technocracy.


Another drug interaction.

Another drug interaction.


Flashes in astronaut's eyes.

Flashes in astronaut's eyes.


Controlling gastric acid.

Controlling gastric acid.


Gelastic epilepsy.

Gelastic epilepsy.


Infant mortality and population structure.


Effects of large doses of colistin sulphomethate sodium on renal function. High doses of colistin were used in the treatment of severely ill patients with refractory klebsiella chest and urinary tract infections. At the same time renal function was monitored to determine possible nephrotoxicity. In all patients it produced acute renal failure and in some acute tubular necrosis. Though renal failure contributed to the final cause of death in some cases, in the majority death was due to the primary neurological illness.


Endocrine and metabolic disordes in bronchial carcinoma. In an unselected series of 185 patients with histologically confirmed bronchial carcinoma 16 had endocrine disturbances attributable to the tumour (excluding pulmonary osteoarthropathy). Of these, 11 patients had hypercalcaemia; three inappropriate secretion of antidiuretic hormone; one Cushing's disease; three hypertrophic osteoarthropathy; and one gynaecomastia. Cushing's disease and inappropriate antidiuresis are specifically associated with oat-cell tumours, and hypercalcaemia occurs most frequently with squamous carcinoma. A negative correlation exists between gynaecomastia and osteoarthropathy on the one hand and oat-cell carcinoma on the other.


Interference of iron with the absorption of tetracyclines in man. Ferrous sulphate administered together with tetracycline and three of its derivatives-oxytetracycline, methacycline, and doxycycline-was found seriously to impair the absorption of these antibiotics. Thus even small doses of iron taken simultaneously should be avoided during tetracycline treatment.


Southey's tubes and vulval oedema.

Southey's tubes and vulval oedema.


Cancer of the prostate. II.

Cancer of the prostate. II.


Evaluation of home nurse attachment in Bristol. By the end of June 1969 home nurses in Bristol were attached to 18 general practices caring for about 137,000 patients, or about one-third of the city's population. Attachment was associated with an increase by about one-third in the number of patients referred by general practitioners for home nursing. Additional benefits derived from attachment during the nine months from January to September 1969 were 2,047 items of service performed by nurses in general practitioners' surgeries, 65 home visits to patients who were not receiving domiciliary nursing care, improved communications between general practitioners and nurses, and opportunities for both doctors and nurses to widen their fields of work. The travelling expenses paid to Bristol's nurses increased by 9.5%.It is suggested that the benefits to patients, doctors, and nurses of attachment far outweigh the costs and that there is scope for extending the role of the attached nurse in the surgery and in home visiting.


Group occupational health service in a developing country. In 1967 an experimental group occupational health service was set up in Dar es Salaam to provide direct service to industrial firms. Larger companies were visited by a doctor, smaller firms in rotation by auxiliaries. After three years 65 companies had joined with over 15,000 employees, and workers were attending the group dispensaries at a rate of over 250,000 visits a year. Such an approach through direct service to the working community appears to be more appropriate to a developing country than a purely advisory central occupational health unit.


Lactic acidosis and the M.D. thesis.

Lactic acidosis and the M.D. thesis.


Ban on barbiturates.

Ban on barbiturates.


What is the best coronary car?

What is the best coronary car?


Jet vaccination.

Jet vaccination.


Postpartum renal failure.

Postpartum renal failure.


Information service on occupational health.


Postoperative leg vein thrombosis.

Postoperative leg vein thrombosis.


Phentolamine in heart block.

Phentolamine in heart block.


Calcium metabolism in patients with epilepsy.


Skin disease and the gut.

Skin disease and the gut.


Brain abscess: a world record?

Brain abscess: a world record?


Changing ambulatory care: a reply to Dr. Gelb.


The forum. Environment and health. Billions of Christmas seals.


Effect of local x-irradiation on the dissemination of Ehrlich carcinoma transplanted intracerebrally.


Total hemocyte counts of honey bee larvae (Apis mellifera L.) from various elevations.


Target organs of 131-I-chorionic gonadotrophine in immature female rat.


Criteria for return to work. Case study of hypertensives.


Reduction of cold-influenza absenteeism in a factory.


An investigation of personal constructs through nonverbal tasks.


Dichotic stimulation as a method of assessing disorder of attention in overinclusive schizophrenic patients.


Forearm blood flow in response to stress.


Comparison of hypnotic analgesia and hypnotic relaxation during stimulation by a continuous pain source.


Treatment components in implosive therapy.


A psychophysiological analysis of fear modification using an automated desensitization procedure.


Antecedents to outcome in group counseling with institutionalized juvenile delinquents: effects of therapeutic conditions, patient self-exploration, alternative sessions, and vicarious therapy pretraining.


Factors associated with accuracy of prediction of posthospitalization adjustment.


Relation of formal thought disorder to the communication deficit in schizophrenics.


The immediacy hypothesis and response-produced stimuli in schizophrenic speech.


Thematic content and trials effects in the size estimation of meaningful stimuli.


An experimental investigation of behavior rehearsal in assertive training.


Effect of hypnotically induced hallucination of a color filter.


Use of behavioral therapy in the reinstatement of verbal behavior in a mute psychotic with chronic brain syndrome: a case study.


Some psychiatric observations on a group of maladjusted deaf children.


Age differences in the discrimination shift learning of young children.


A follow-up study of school phobic adolescents admitted to an in-patient unit.


A modular teaching unit for research and therapy with children.


An assessment of serum 57Co cyanocobalamin as an index of vitamin B12 absorption. A technique has been developed for accurately assaying serum and urine (57)Co cyanocobalamin during the conventional Schilling test. Serum and urine radioactivity in a large number of patients has been correlated and the precise normal limits have been determined by statistical analysis. The implications of this for investigating conditions other than pernicious anaemia and the malabsorption syndromes are stressed.


Vitamin B12 absorption in some neurological and neuroendocrine disorders. An assessment of vitamin B(12) absorption in neurological patients has been made by both serum and urine counting of (57)Co cyanocobalamin during the conventional Schilling test. Although patients with pernicious anaemia, some with subacute combined degeneration of the cord, have been studied, emphasis in the discussion is placed on the significantly increased excretion of the radioactive vitamin in a group of patients with pituitary insufficiency. Results are also given for epileptic patients who have developed folate deficiency (as assessed by serum folate levels) coincidental with anticonvulsant therapy, as well as for some patients who have had neurological symptoms or signs following partial gastrectomy operations.


Studies on the 57Co vitamin B12 plasma level absorption test. Results of the (57)Co vitamin B(12) plasma level absorption test are described in 163 patients. The use of intramuscular carbachol with the test and the presence or absence of current vitamin B(12) therapy did not affect the test results. Injection of 1,000 mug of unlabelled vitamin B(12) during the test augmented plasma levels in patients with normal absorption but tests without this injection gave satisfactory differentiation between the normal and malabsorption ranges. Results from patients having had a gastrectomy, ileal resection, or a past history of adult coeliac disease are also described. Amongst patients with presumed Addisonian pernicious anaemia, two with unresolved equivocal results and three with falsely normal results were found. The significance of these is discussed.


Thermal damage to red cells.

Thermal damage to red cells. Erythrocytes from a burned patient show a temporal sequence of morphological changes. Immediate severe changes occur which are followed by a transient phase only of less abnormal morphology. Heating whole blood in vitro to 49 degrees C instead of 50 degrees C does not show the expected dose response curve. Heating whole blood in vitro to 50 degrees C induces progressive morphological changes. Fractionation of whole blood and subsequent heating to 48 degrees C show the older cells to be less deformable.


Effect of feeding fat on fibrinolysis, Stypven time, and platelet aggregation in Africans, Asians, and Europeans. The effects of acute fat feeding on fibrinolytic activity, platelet aggregation, and Stypven time in 10 Africans and 10 Asians are presented and compared with the results previously obtained in 10 Europeans. These indicated that the inhibition of fibrinolytic activity seen in Europeans does not occur in either Africans or Asians although the Stypven time was shortened in all three groups. Platelet aggregation, as measured by the Chandler's tube technique, was inhibited by fat feeding in Europeans but was unchanged in Africans and Asians. The results also indicate that the fibrinolytic activity of Africans and Asians is greater than that of Europeans.


Alkaline phosphatase activity of polymorphonuclear leucocytes and lymphocytes separated from normal human blood. Suspensions of polymorphonuclear leucocytes and lymphocytes were prepared from normal human blood by the glass bead column method of Rabinowitz (1964). The alkaline phosphatase activity of the separated cells was determined by biochemical and cytochemical techniques. Lymphocytes were found to contain an enzyme catalysing the hydrolysis of beta-glycerophosphate at alkaline pH but not of p-nitrophenylphosphate at the same pH and in the same buffer system. The alkaline phosphatase in polymorphonuclear leucocytes catalysed the hydrolysis of both substrates equally. The importance of this finding to the interpretation of clinical data is discussed.


The connective tissue in livers of children. The amount of connective tissue present, relative to the amount of parenchymal tissue, has been assessed in a random series of 200 livers from children dying from non-hepatic disease. The amount of connective tissue in the left liver is approximately twice that in the right liver. The connective tissue in both lobes progressively diminishes during childhood but at all times remains higher than that in adults.Increased amounts of connective tissue in the liver in children is probably non-specific and related to the degree and duration of shock and hypoxia in the immediate postnatal period.


Glomerular fine structure in mixed membranous and proliferative glomerulonephritis. A case of mixed membranous and proliferative glomerulonephritis has been studied by light and electron microscopy. Electron microscopy has shown that the cellular proliferation is mesangial in origin and that there are qualitative and quantitative alterations in the filtration basement membrane. In addition there are numerous examples of direct contact between filtration basement membrane and neutrophil polymorphonuclear leucocytes. This latter phenomenon is good direct evidence that interaction of glomerular-bound antigen-antibody complex and complement has taken place. The light and electron microscopic evidence is thus in favour of the histopathological entity, mixed membranous and proliferative glomerulonephritis, being fundamentally a proliferative glomerular lesion initiated by complement-induced basement membrane injury.


Inconsistency of temperature in plastic containers.


Rheumatoid heart disease with complete heart block. A case of florid rheumatoid heart disease with complete heart block is described, and the histopathology of the atrioventricular conducting tissue is described in detail.


Hypo-osmotic urine in Nereis diversicolor.


Effects of sub-lethal high temperature on an insect, Rhodnius prolixus (Stål.). IV. Egg formation, oviposition and sterility.


Observations on the myo-neural physiology of a polyclad flatworm: inhibitory systems.


The central course of the hair afferents and the pattern of contralateral activation in the central nervous system of the scorpion, Heterometrus fulvipes.


Osmoregulation of Lampetra fluviatilis L. and Petromyzon marinus (Cyclostomata) in hyperosmotic solutions.


Ionic content of haemolymph in the cockroach, Periplaneta americana. A critical analysis.


Effects of sub-lethal high temperature on an insect, Rhodnius prolixus (Stål.). V. A possible mechanism of the inhibition of reproduction.


Oxygen consumption in ammocoetes of the lamprey Ichthyomyzon hubbsi Raney.


Chloride regulation at low salinities by Nereis diversicolor (Annelida, Polychaeta). I. Uptake and exchanges of chloride.


Chloride regulation at low salinities by Nereis diversicolor (Annelida, Polychaeta). II. Water fluxes and apparent permeability to water.


Electrophysiological and endocrinological correlates during the metamorphic degeneration of a muscle fibre in Galleria mellonella (L.) (Lepidoptera).


A method for assessing the size of a protein from its composition: its use in evaluating data on the size of the protein subunits of plant virus particles.


Changes in the ribosomes extracted from Mung beans infected with a strain of tobacco mosaic virus.


An analysis of the histochemical procedure for sodium ion detection.


Hybridization studies with the RNA of the WS strain of influenza virus and its neurotropic variant NWS.


Uptake of 3H-norepinephrine by fluorescent nerves of the heart.


Seasonal changes in reproductive and related organs in the pine vole, Microtus pinetorum, in southwestern Virginia.


Biotelemetric studies of temperature regulation and torponin the echidna, Tachyglossus aculeatus.


Vaginal trichomoniasis and precancerous states of the cervix: a preliminary report.


The curve of labour used as a teaching device in Uganda.


The effects of schistosomiasis on the fallopian tubes in the African female. 104 patients among 151 subjected to removal of genital tissue for gynecological purposes in the practice of 1 physician at the Harari Central Hospital in Salisbury, Rhodesia, were adequately assessed for evidence of bilharziasis in the Fallopian tubes, as well as for the presence of bilharzial ova in the urine, stool, or rectal biopsy.  Of the 104, 10 had definite evidence of bilharziasis in the tubes, and 3 also had Schistosoma hematobium in the urine, stool, or rectal biopsy.  Another 3 had evidence of S. mansoni associated with Schistosoma hematobium in the rectal biopsy.  4 had no evidence of bilharziasis in the urine, stool, or rectal biopsy.  31 patients had no evidence of bilharziasis in the tubes, but S. haematobium was present in the urine, stool, or rectal biopsy.  63 patients had no evidence of bilharziasis in the tubes, urine, stool, or rectal biopsy.  During the same period 38 ectopic pregnancies were treated by salpingectomy and the tubes examined.  6 of the patients (16%) had concomitant bilharzial involvement, compared with 4 of 66 patients (6%) without ectopic pregnancy, not a significant difference.  In only 2 of the 6 ectopic pregnancies associated with bilharziasis was enough inflammatory reaction present to have been a possible factor in the production of the ectopic pregnancy.  In the other 4 cases the ova probably caused no structural damage to the tubes and cannot therefore be implicated in the causation of the ectopic pregnancy.  It was not possible to demonstrate any significant difference between the fertility of patients with bilharziasis of the tubes compared with those without it.  The findings suggest that ectopic pregnancy associated with bilharziasis may occur at a somewhat earlier age than ectopic pregnancy associated with pyogenic salpingitis.


Pregnancy and delivery after bilateral adrenalectomy for phaeochromocytoma. Case report and review of literature.


An unusual case of compound presentation.


Radical operation for carcinoma of the vulva. A new approach to wound healing.


Out-patient diagnostic curettage.

Out-patient diagnostic curettage.


Suction evacuation of uterus for incomplete abortion.


Studies on the urinary excretion of gonadotrophins during the normal menstrual cycle in young women.


The vascular patterns in myomatous uteri.


The effect of ethanol on the myometrial response to oxytocin in women at term.


A clinical evaluation of the selenomethionine uptake test.


The heat-stable alkaline phosphatase content of human placentae.


The mechanism of action of exogenous ATP for the treatment of fetal hypoxia during delivery.


Serum heat-stable alkaline phosphatase in pregnancy complicated by hypertension.


The effect of ATP on the fetus in danger during labour.


Changes in liver lysosomes and cell junctions close to an invasive tumour.


The interrelations of complement and a prostaglandin-like substance in acute inflammation.


The general practitioner, the hospital and community services.


Peliosis hepatis: case report and review of pathogenesis.


Laying the foundation--teaching students.


Maintaining and testing standards.

Maintaining and testing standards.


Medical care, common world problems and dilemmas.


Future patterns of practice.

Future patterns of practice.


Avulsion of the flexor profundus tendon insertion.


The effect of topial Sulfamylon on water loss through burn eschar: a re-evaluation.


Problems related to the management of combat wounds caused by specific ordnance.


Experimental fat embolism: treatment with phenoxybenzamine.


Appearance of defective virions in clones of reovirus. Virus obtained from five plaques of reovirus was serially passaged in L cells. Defective virions arose in each clone by the seventh passage. Such defective virions lacked the largest of the 10 segments of the double-stranded ribonucleic acid genome.


Comparison of the virion polymerase of reovirus with the enzyme purified from reovirus-infected cells. Reovirus has in its protein coat an enzyme which catalyzes the net synthesis of the three size classes of virus-specific, single-stranded ribonucleic acid (RNA). For synthesis of 24, 19, and 14S single-stranded RNA, Mn(++) was the preferred divalent cation, and ammonium sulfate at an optimal concentration of 4.2% of saturation was an absolute requirement. During synthesis, the parental double-stranded RNA was conserved in the viral core and the newly synthesized completed RNA chains were released as free RNA. The viral cores synthesizing RNA had properties consistent with the presence of nascent RNA on their outer surface. The enzyme-template complex from the infected cells described in an earlier paper was comprised of viral cores already active in the in vivo synthesis of single-stranded RNA. This pool of viral cores was newly made during infection, and exponential increase in the number of particles in this pool, as detected by the increase in enzymatic activity, occurred 2 hr earlier than that in mature virus.


Phospholipid content of human and guinea pig muscle: post-mortem changes and variations with muscle composition.


Association of phospholipid-cholesterol micelles with rat heart mitochondria: stimulators and inhibitors.


Chain length specificity of the saturated fatty acyl desaturase in rat liver preparations.


Graphic presentation of computer-derived Schlieren lipoprotein data.


Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots.


The future of antiviral chemotherapy.

The future of antiviral chemotherapy.


The surgery of peptic ulcer: a review.

The surgery of peptic ulcer: a review.


Mammography.

Mammography.


Speech disorders in children.

Speech disorders in children.


Hypospadias.

Hypospadias.


Serum hepatitis as a professional risk.

Serum hepatitis as a professional risk.


Pulmonary embolism.

Pulmonary embolism.


The problem of head and spinal injuries: prevention of the second accident.


Unusual features of haemorrhage in a patient on warfarin sodium.


A fatality associated with trichloroethylene inhalation.


Myocardial infarction and coronary atherosclerosis in forensic autopsy material.


Epilepsy and driving.

Epilepsy and driving.


Scientific problems associated with the Road Safety Act 1967.


The training of questioned document examiners.


A knife swallowed in prison retrieved at oesophagoscopy.


Mental health review tribunals.

Mental health review tribunals.


The three special hospitals in England and patients with dangerous, violent or criminal propensities. II. Patients with dangerous, violent or criminal propensities.


An integrated health-science core library for physicians, nurses and allied health practitioners in community hospitals.


Pulmonary embolism and unexpected death in supposedly normal persons. A second look.


Resection of acute ventricular aneurysm and ruptured interventricular septum after myocardial infarction.


By the London Post. Good hospital practice.


Core health-science libraries.

Core health-science libraries.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 53-1970.


Consent to continued pregnancy.

Consent to continued pregnancy.


Levodopa and tests for ketonuria.

Levodopa and tests for ketonuria.


Effects of expanded health insurance.

Effects of expanded health insurance.


Creative literature for doctors.

Creative literature for doctors.


Junk mail, revisited.

Junk mail, revisited.


Biochemical determination of urinary bladder carcinogens in human urine.


Responsibilities and risks involved in the use of wood protecting chemicals.


Metabolism of industrial solvents. 1. The biotransformations of benzene and benzene substitutes.


Sciatica and the straight-leg-raising test in manipulative treatment.


Poliomyelitis in Uganda.

Poliomyelitis in Uganda.


The intervertebral foramen.

The intervertebral foramen.


Physiotherapy in the treatment of poliomyelitis in Uganda.


Nephropathy and edema syndrome induced in miniature swine by corn cultures of Penicillium viridicatum.


Routine pre-and post-operative physiotherapy. A preliminary trial.


Prosthesis in plastazote.

Prosthesis in plastazote.


What is N.A.P.S.?

What is N.A.P.S.?


Recent developments in personal protective clothing and equipment.


Protective clothing for fishermen.

Protective clothing for fishermen.


Protective clothing for fishermen: design factors.


Protective clothing for fishermen: assessment of design.


Protective clothing for underground workers.


Articulated suits: principles and design.


Dynamic insulation: an equation relating airflow, assembly thickness and conductance.


Royal aircraft establishment water-cooled suit.


Water-cooled suit for protection against hot environments.


Recent developments in ear protection.

Recent developments in ear protection.


Disposable protective garments.

Disposable protective garments.


The use of high activity cobalt 60 sources for intracavitary and surface mould therapy.


Afterloading techniques.

Afterloading techniques.


Varieties of adrenal hyperplasia.

Varieties of adrenal hyperplasia.


Diagnosis and management of congenital adrenal hyperplasia.


Vulva-vaginoplasty.

Vulva-vaginoplasty.


Experience with the Strassmann operation in Dundee.


An operation for prolapsed rectum in women.


A new technique for estimating oestriol in plasma or other fluids.


A method of tubal splinting.

A method of tubal splinting.


A non-operative method of controlling stress incontinence.


Positive vaginal cytology recurring after total hysterectomy for carcinoma-in-situ of the cervix (three cases).


Extrauterine pregnancy.

Extrauterine pregnancy.


Pure gonadal dysgenesis.

Pure gonadal dysgenesis.


The management of locked twins.

The management of locked twins.


Immunological aspects of clinical leprosy.


Immunological aspects of experimental leprosy in the mouse.


The mode of action of cytotoxic drugs.

The mode of action of cytotoxic drugs.


The complications of antilymphocyte therapy.


Microbiological aspects of cytotoxic drug therapy.


The complications of bone marrow suppression.


The use of standardized cell substrates as an alternative to primary animal tissue for vaccine production.


Application of computers in association with animal experiments.


An experiment on a baby with idiopathic hypercalcaemia.


Composition and function of future departments of clinical measurement.


Training for measurement in medicine. Types of training required.


Measurement of the physical properties of valve homografts.


Fluid mechanics of model aortic and mitral valves.


he preparation of homografts: are they still homografts?


Inner sustainment: metapsychological considerations.


Mechanisms of incorporation of homografts and heterografts.


Soft tissue placentography and the uterine compressor.


Staffing levels--a look to the future.

Staffing levels--a look to the future.


An instant step-wedge.

An instant step-wedge.


Cardiac arrest in the x-ray patient.

Cardiac arrest in the x-ray patient.


The elimination of scattered radiation.

The elimination of scattered radiation.


Failure to alter skin inflammation by hypnotic suggestion in five subjects with normal skin reactivity.


Psychologic correlates of growth hormone and adrenal secretory responses of patients undergoing cardiac catheterization.


The use and care of a radioactive source, caesium 137, in University College Hospital, Ibadan, Nigeria.


Dermoid cyst in the liver.

Dermoid cyst in the liver.


Emigrating British physicians.

Emigrating British physicians.


Disease and "development" in Africa.

Disease and "development" in Africa.


Thyroid "hot spots": their relationship to life stress.


The stress of aircraft carrier landings. II. 3-methoxy-4-hydroxyphenylglycol excretion in naval aviators.


Psychological adaptation and development under acculturative stress: toward a general model.


Pregnancy in teenage girls.

Pregnancy in teenage girls.


Factors affecting non-participation in a county-wide tuberculin testing program in Southern Appalachia.


The referring of patients as a component of the medical interaction system.


Psychiatric implications of health and illness in a Maya Indian group: a preliminary statement.


The development of the social and health sciences in Japan.


Natural resolution of hepatic ultrastructural changes induced by DL-ethionine.


Penicillamine-induced changes in growing rats. I. Epiphyseal plate.


The ultrastructure of primary water-clear cell hyperplasia of the parathyroid glands.


The uncertain future of clinical psychology.


Uncommon morphologic features in subacute sclerosing panencephalitis (SSPE). Report of two cases with virus recovery from one autopsy brain specimen.


Financial provisions in APA-approved clinical internships.


Heparin requirements in patients with acute myocardial infarction.


A preliminary evaluation for primary aldosteronism.


Spontaneous rupture of the esophagus.

Spontaneous rupture of the esophagus.


Dermatoglyphics in the Holt-Oram syndrome.


Staphylococcus epidermidis endocarditis complicating a Starr-Edwards prosthesis. A therapeutic dilemma.


Traumatic hemolysis with rupture of aneurysm of sinus of Valsalva.


Taxonorics. II. Formats and coding systems for data processing.


Hyperdynamic beta-adrenergic circulatory state. An overview.


On a contradiction between intent and enactment.


The clinical spectrum of plague in Vietnam.


Candida at Boston City Hospital. Clinical and epidemiological characteristics and susceptibility to eight antimicrobial agents.


Rehabilitation and functional status after surgery for valvular heart disease.


The oxidation of organic anions by flavins.


Application of mass spectrometry to protein chemistry. II. Chemical ionization studies on acetylated permethylated peptides.


Charge transfer interactions in transketolase-thiamine pyrophosphate complex.


Induction of ceruloplasmin synthesis by copper.


Effects of neutralization of amino groups on the kinetics of chymotrypsin.


Small polypeptide components of the Bacillus thuringiensis parasporal crystalline inclusion.


Ethylene formation from peptides of methionine.


The crystal structure of two forms of 1-ethyl-5-bromouracil.


Antigenic activity of prostaglandins.

Antigenic activity of prostaglandins.


The action of hexadecyltrimethyl ammonium bromide on bilayer lipid membranes.


Chemical modification of tRNA-Tyr-yeast with bisulfite. A new method to modify isopentenyladenosine residue.


Separation of synthetic deoxyribo-oligonucleotides by thin layer chromatography.


Developmental increases in activity and sensitivity to mercury of human and chicken skeletal muscle phosphoglycermutase.


Isolation of tRNA-Phe-yeast half-molecules by gel filtration and chromatography on benzoylated DEAE-cellulose at high temperature.


Isolation and characterization of a lysine-sensitive aspartokinase from a multicellular plant.


Ascorbic acid interaction with metallothionein.


A new procedure for the preparation of highly labeled intact 32P RNA from bacteriophage R-17.


Therapy of hereditary mouse muscular dystrophy with coenzyme Q7.


Variation with temperature of the apparent molecular weight of rat-liver mitochondrial RNA, determined by gel electrophoresis.


Deficiency of coenzyme Q9 in mice having hereditary muscular dystrophy.


Biosynthesis of blood group active glycoproteins: a peptidyl: alpha-N-acetylgalactosaminyltransferase from human submaxillary gland and stomach mucosal tissue.


Potassium ion as an essential factor for binding of vitamin B 12 coenzyme to apopropanediol dehydratase.


Hydroxyproline containing chromatin proteins from tobacco callus tissue.


Stimulation of RNA synthesis in isolated mammary cells by insulin and prolactin bound to sepharose.


Typing of Rhizobium by phages.

Typing of Rhizobium by phages.


Ergotamine production and metabolism of Claviceps purpurea strain 275 FI in stirred fermenters.


Keratinophilic activity in species of Corynebacterium.


Diacetyl reductase of Lactobacillus casei.


Influence of cardiac disease upon partial and complete interruption of the vena cava for thromboembolism.


Secondary biosynthesis of aflatoxin B in Aspergillus parasiticus.


Splénic artery aneurysm.

Splénic artery aneurysm.


Intracellular development of a bacteriophage of Clostridium perfringens.


Sinus histiocytosis and mammary carcinoma. Study of 366 radical mastectomies and an historical review.


The natural history and management of mammary cancer metastatic to the femur.


The possible role of riboflavin deficiency in epithelial neoplasia. II. Effect of skin tumor development.


Survivorship following treatment for cancer of the colon and rectum.


Familial juvenile polyposis of the colon.


Surgical therapy of the valvular complications of bacterial endocarditis.


A new method for long-term coronary sinus blood sampling in the unanesthetized dog without thoracotomy.


Effect of irradiation on lymph flow and filtration function of lymph nodes.


Angioarchitecture of pulmonary malignancies in humans.


Multiple noduli cutanei and urinary tract abnormalities. A possible significant association.


Ultrastructure of congenital fibrosarcoma.


Surgical treatment of Wolff-Parkinson-White syndrome.


Fine structure of a functional adrenal cortical adenoma.


Spindle-cell variant of squamous carcinoma. A light and electron microscopic study of 13 cases.


Childhood renal carcinoma.

Childhood renal carcinoma.


The cartilage analogue of fibromatosis (aponeurotic fibroma). Further observations based on 7 new cases.


Malignant histopathologic counterpart of the benign lymphoepithelial lesion.


Primary adenocarcinoma of the mid-esophagus arising in ectopic gastric mucosa with associated hiatal hernia and reflux esophagitis (Dawson's syndrome).


Primary leiomyosarcomas of the inferior vena cava. Report of a case and review of the literature.


Complementary value of pulmonary angiography and mediastinoscopy in individualizing treatment for patients with lung cancer.


The effect of nonspecific immune stimulation with corynebacterium parvum on patterns of tumor growth.


Epilepsy in African hospital practice.

Epilepsy in African hospital practice.


A medical research safari: fruits and frustrations.


Atrial flutter.

Atrial flutter.


Age of first conception in rural Mashonaland.


Pancreatitis.

Pancreatitis.


Peculiarities in dermatology. A case of knuckle pads.


A learning experience in helping parents get what they want.


Health care through Head Start.

Health care through Head Start.


A differential use of group homes for delinquent boys.


Family participation in hospital care for children.


A clinic for children with learning disabilities.


Isolation of commisterone, a new phytoecdysone from Cyanotis vaga.


The total synthesis of racemic cryptosporiopsin, a fungitoxic antibiotic.


Terpenoid alkaloids from Murraya koenigii Spreng. IV. Structure and synthesis of mahanimbinine.


Picralinal--a key alkaloid of picralima group from Alstonia scholaris R. Br.


Fluorescent metabolites in mold-damaged wheat flour.


New intermediates in phaemelanogenesis in vitro.


The synthesis of monofluoroacetic acid by a tissue culture of Acacia georginae.


Autoradiographic identification of rabbit retinal neurons that take up GABA.


The effect of anaerobic incubation upon 2,3-diphosphoglycerate synthesis in vitro.


Effect of spermine on the kinetics of estradiol hydroxylation by rat liver microsomes.


Isoforms of baker's yeast transketolase.


Absence of dehydroxylation of caffeic acid in germ-free rats.


'Rupture sites' in elastin during the course of organo-alkaline hydrolysis.


Conversion of gamma-hydroxybutyrate to gamma-aminobutyrate by mouse brain in vivo.


Mass and RNA content of rat spinal anterior horn neurons during postnatal development.


Phenolic content of sugarcane in relation to red rot disease.


Effect of emetine on certain aspects of protein metabolism.


Effect of an inhibitor isolated from onion (Allium cepa Linn.) bulbs on the activity of some of the enzymes involved in starch biosynthesis.


Molecular alterations of human fibrinogen by ultrasonic frequencies.


Influence of magnesium and cysteine on vasopressin-induced contractions in various canine blood vessels.


Relationship between the resting blood pressure and depressor responses evoked by compression of the eyeballs.


The interaction of hypothalamic self-stimulation and temperature regulation.


Vagus pneumonia as membrane phospholipase activation.


Hormonal action of certain biologically active compounds in Agrotis ypsilon larvae.


Ionic mechanisms of opposite synaptic actions of an interneuron in the abdominal ganglion.


Postjunctional potentials and cardiac acceleration in a mollusc (Dolabella auricula).


Photoperiod manipulation to control diapause in the pink bollworm, Pectinophora gossypiella.


The importance of extracellular sodium and potassium for acetylcholine-evoked salivary secretion.


Neuroanatomical regions relevant to production and analysis of vocalization within the avian torus semicircularis.


Anomalous changes in the plasma antidiuretic activity of hydrated dogs after the cessation of intravenous infusion of arginine vasopressin.


Filamentous structures in normal taste bud.


Variations in the Golgi complex of mouse prolactin cells at different times in a circadian period.


The effect of short term exposures to 100 per cent oxygen on the fine structure of proximal convoluted tubules.


Monoamine-containing structures in the nerve cord of some representatives of Diptera (Insecta).


Ultrastructure of the 'onion bodies' of the sensory pore X-organ of Paratya tasmaniensis Reik (Crustacea, Decapoda).


A regular actin filament lattice in a vertebrate smooth muscle.


Effects of reserpine on development of 7,12-dimethylbenzanthracene induced mammary tumors in female rats.


Extranuclear 3H-thymidine incorporation in subcortical cytoplasmic organelles of primary oocytes in the Japanese quail (Coturnix coturnix japonica).


The destruction of lymphoma cells by activated human lymphocytes.


Experimental myocarditis: enhancement by the use of pertussis vaccine in Lewis rats.


Effect of caerulein infusion on glucagon secretion in the dog.


Prolactin-inhibiting activity in hypophysial stalk blood and elevation by dopamine.


Pineal inhibition of compensatory testicular enlargement in light-deprived hamsters.


A nutritional method for the isolation of morphological mutants of Neurospora crassa.


A diploid population of Poa annua L. from Australia.


Refrigerating apparatus for medical use.


Cytogenetic studies of dolphin (Tursiops truncatus) by an extended tissue culture technique.


Child-care attitudes and emotional disturbance among mothers of young children.


Quick discharge possible for many surgical patients.


The Paul principle: when technology outgrows the man.


The asthmatic wheeze which isn't caused by asthma.


Ten years' dietary treatment of primary hyperlipidemia.


Terminal ECG in the aged. Electrocardiographic, pathological, and clinical correlations.


Human strength: terminology, measurement, and interpretation of data.


Drivers' judgments in overtaking and passing.


Laboratory panel estimation of consumer assessments of taste and flavor.


Autonomic responses during a replicable interrogation.


A questionnaire measure of achievement motivation.


Effects of level and rate of body surface cooling on psychomotor performance.


The physiological response to the communication modes: reading, listening, writing, speaking, and evaluating.


The measurement of speaker credibility.

The measurement of speaker credibility.


Some new mutants of house flies and their linkage groups and map positions.


Metepa as a chemosterilant for the adult male spruce budworm, Choristoneura fumiferana.


Dietary fats and fatty-acid composition of bollworms as factors influencing insecticide susceptibility.


Evaluation of aliphatic amines against larvae and pupae of mosquitoes.


Metabolism of 14C-labeled N2,N2,N4,N4-tetramethylmelamine in male house flies.


Spatial action of mosquito repellents.

Spatial action of mosquito repellents.


Residues of fenthion in corn silage and effects of feeding dairy cows the treated silage.


Development of bisensory memory in culturally deprived, dyslexic, and normal readers.


The difference model: a new explanation for some reading difficulties.


Effects of chlorpromazine in the pigeon under a second-order schedule of food presentation. Chlorpromazine was studied for its effects on responding under a second-order schedule in which food was presented following a sequence of 20 one-minute fixed-interval components. A brief visual stimulus occurred at the completion of each fixed interval including the one that terminated with food presentation. Chlorpromazine showed rate-dependent effects in that it increased low rates in the early components of the second-order schedule and, to a lesser extent, decreased high rates in the later components. Chlorpromazine also increased rates in the early quarters within the 1-min fixed-internal components and to a smaller extent decreased rates in the final quarter. The alteration in the patterns of responding within 1-min fixed-interval components terminating in a brief stimulus presentation was substantially less than that which occurred throughout the succession of 1-min fixed-interval components terminating in food presentation, thus suggesting that the presentation of the brief stimulus exerted more control over responding within components than did food presentation over the sequence of components. This result and others suggest that studies using drugs may be useful in elucidating the factors controlling patterns of responding in second-order schedules.


Generalization and response mediation of a conditional discrimination. Fifteen pigeons were given conditional discrimination training in which a colored sample stimulus determined which of two line comparison stimuli (vertical and horizontal) was correct. As part of the conditional discrimination procedure, birds were required to make an "observing response" to the sample stimulus presented on a wide key. The location on this key of the required observing response for the two sample stimuli differed by 0, 3, or 6 in. (0, 7.6, or 15.2 cm) for three groups of birds. Accuracy of conditional discrimination performance was directly related to the amount of separation. In subsequent generalization tests with novel sample stimuli, both observing-response location and comparison responding changed within the same region of the wavelength continuum from that appropriate for one of the training samples to that appropriate for the other. A maintained generalization test (continued reinforcement for training stimuli) revealed this relation more strongly. A test in which observing-response location was the only sample stimulus of a conditional discrimination revealed stimulus control by this observing response, supporting a response mediation interpretation of the data.


Forgetting and conditioned suppression: role of a temporal discrimination. Several experiments have found complete retention of conditioned suppression when overall suppression to the signal for shock was measured. The present experiment examined retention of conditioned suppression but did so with a paradigm that produced temporal discrimination of shock occurrence. Nine rats were exposed to a flashing light signal of 5-min duration that always terminated with a shock. After several months, a temporal discrimination was well established, as shown by maximum suppression toward the end of the signal period. After remaining in the home cage for 25 days, the rats were again subjected to the conditioning procedure. The overall level of suppression remained the same but the temporal discrimination was not observed.


Electron microscopic study of inhibition of macrophage migration in delayed hypersensitivity.


Transfer of the delayed hypersensitivity skin reaction in the guinea pig using RNA-treated lymphoid cells.


Primary rejection of homologous intraperitoneal fibroblasts: an electron microscopic study.


Human immunologic response to soluble antigens. I. Hypersensitivity induced by a hapten-altered native protein.


Carbonyl iron: a new adjuvant for experimental autoimmune diseases.


Ultrastructural localization of horseradish peroxidase and endogenous peroxidase activity in guinea pig peritoneal macrophages.


Partial purification and characterization of a dengue virus soluble complement-fixing antigen.


Sebaceous gland response in man to prolonged total caloric deprivation.


Systemic lupus erythematosus: electron microscopic localization of in vivo bound globulins at the dermal-epidermal junction.


Catecholamines in the hair cycle of rats.


Stratum granulosum: dissection from cattle hoof epidermis.


The effect of ADH on eccrine sweating in the rat.


Observations of fenestrated capillaries in the human scalp.


The College of Medicine in the 70's.

The College of Medicine in the 70's.


Prevention of urinary infection in patients with indwelling catheters.


Tuberculous peritonitis: use of the hook needle biopsy.


Porphyria: the little mimic. An interesting case with a general review.


Rubella vaccines.

Rubella vaccines.


Neurologic manifestations of infective endocarditis.


A medical-surgical clinic service in a mental hospital.


Iodide induced myxedema: a failure of autoregulation.


Percutaneous transhepatic cholangiography.


Utilization of current knowledge of the educational process.


Physicians for the care of the sick.

Physicians for the care of the sick.


The educational process: viewpoints of the discussion groups.


The gap between urgent need and present actions.


Physician manpower needs: viewpoints of the discussion groups.


Workshop on the Medical School Curriculum. The questionnaire and its analysis.


Site visits to 12 medical schools.

Site visits to 12 medical schools.


Workshop on the Medical School Curriculum. Introduction.


Curriculum improvement in the university.


Social demands upon health care delivery.


The response of the university medical center to social demands.


Social demands: viewpoints of the discussion groups.


Workshop on the Medical School Curriculum. Principal recommendations of the Workshop.


Cognitive learning and the educational process.


When does dissonance fail? The time dimension in attitude measurement.


An exploratory study of the effects of emotionally toned incidental stimuli.


Leadership style and role differentiation as determinants of group effectiveness.


Birth order and hierarchical versus innovative role requirements.


Triadic consistency and false heart-rate feedback.


Self-esteem, attitude similarity, and attraction.


An evaluation of a rotating drum densitometer and its application to precession photographs of protein crystals.


An environmental cell for the examination of wet biological specimens at atmospheric pressure by transmission scanning electron microscopy.


A scanning electron microscopy of the glomerulus of normal and nephrotic rats.


Morphologic and biochemical effects of a chelating agent, alpha, alpha'-dipyridyl, on kidney and liver in rats.


Parathyroid morphology in suppressible and nonsuppressible renal hyperparathyroidism.


Double contrast technique for postmortem coronary angiography.


Experimental allergic encephalomyelitis. Antiserum inhibition of myelination in vitro.


Bacteroides bacteremia.

Bacteroides bacteremia.


The enema can be a dangerous act.

The enema can be a dangerous act.


Case report. Lymphatic cyst of the stomach.


Experience with atypical of positive cytology smears.


Cortisone glacuoma.

Cortisone glacuoma.


Observations on the epidermis of the miracidium and on the formation of the tegument of the sporocyst of Fasciola hepatica.


A note on the effects of antimalarial drugs on the sporogonous cycle of Plasmodium cynomolgi in Anopheles stephensi.


The distribution and fine structure of the integumentary papillae of the cercaria of Himasthla secunda (Nicoll).


Changes in the chemical composition of Hymenolepis diminuta (Cestoda: Cyclophyllidea) during prepatent development within the rat intestine.


The inhibitory effect of CO2 on the ecdysis of infective Haemonchus contortus cayugensis larvae.


Carbohydrate stores in chickens infected with Eimeria tenella.


The influence of pCO2 and the rate of shaking on the ecdysis of infective Haemonchus contortus cayugensis larvae.


The effects of larval age and cold storage on the ecdysis of infective Haemonchus contortus cayugensis larvae.


Observations on the effect of the rediae of Fasciola hepatica on the lipid composition of the hepatopancreas of Lymnaea truncatula.


Nucleoside diphosphate-sugar 4-epimerases. II. Uridine diphosphate arabinose 4-epimerase of wheat germ. Uridine diphosphate (UDP)-arabinose 4-epimerase (EC 5.1.3.5) has been purified at least 20-fold from wheat germ by MnCl(2) treatment, (NH(4))(2)SO(4) fractionation, dialysis, and Sephadex and diethylaminoethyl cellulose column chromatography. The enzyme has no action on UDP-d-glucose, UDP-d-glucuronic acid, or TDP-d-glucose. The pH optimum is 8.0. Km values are 1.5 mM for UDP-d-xylose and 0.5 mm for UDP-l-arabinose. The equilibrium constant, K, for the reaction UDP-l-arabinose left arrow over right arrow UDP-d-xylose is 1.25. The enzyme is neither activated by nicotinamide adenine dinucleotide nor inhibited by reduced nicotinamide adenine dinucleotide. It is completely inhibited by p-chloromercuri-phenylsulfonate; the inhibition is reversed by cysteine.


Pulmonary candidiasis in fowl.

Pulmonary candidiasis in fowl.


A short down-blistered foot lethal and a congenital, crippling mutant of the domestic fowl.


On the inhibition of tetracycline absorption of dietary calcium.


The effect of aureomycin on the thyroid glands of growing chicks.


Influence of a thiamine deficiency on basal metabolic rate, specific dynamic effect and the efficiency of energy utilization.


Variations in phosphatases in plasma and uterine fluid and in the uterine epithelia of the domestic fowl.


Response of broilers to moenomycin.

Response of broilers to moenomycin.


Preferential utilization of methionine in chicks.


Pulmonary circulation time in the chicken.


Vitamin A deficiency and Eimeria acervulina infection in the chick.


Growth of psychrotolerant pseudomonads and achromobacteria on various chicken tissues.


Effect of various agents in alleviating the toxicity of tannic acid for chickens.


Effect of a chemical additive on Salmonella in poultry feed and host birds.


The isoleucine and valine nutrition of young laying pullets as influenced by excessive dietary leucine.


Effect of gold thioglucose on survival, feed consumption and body weight of broilers.


The response of chicks, ducklings, goslings, pheasants and poults to graded levels of aflatoxins.


Depression of plasma alpha-tocopherol level in chicks infected with avian leukosis.


Aflatoxicosis: the presence of aflatoxins or their metabolites in livers and skeletal muscles of chickens.


Ordinal position and conformity: a role theory analysis.


Compliance to threats as a function of the wording of the threat and the exploitativeness of the threatener.


Interpersonal spacing in natural settings.


Personality and group impression formation as a function of the amount of overlap in evaluative meaning of the stimulus elements.


Marijuana: should it be controlled?

Marijuana: should it be controlled?


Sudden unexpected death due to biliary obstruction.


Calyceal cysts.

Calyceal cysts.


A stainless washable gentian violet specific for candida albicans (monilia) and other vaginal pathogens. One medication for all vaginal infections.


The defibrination syndrome in rabbits following infusion of tissue thromboplastin in the jugular vein.


Effect of anticoagulating and non-anticoagulating concentrations of heparin on the generalized Shwartzman reaction.


Severe hereditary deficiency of factor VII during pregnancy. Evidence for the absence of transplacental diffusion of factor VII.


Corrective effect of sialic acid on the clotting of factor VIII deficient blood.


Severe congenital factor X deficiency in 5-month-old child.


Comparison of the effects of various blood plasma expanders on platelet adhesiveness.


Platelet factor 4(PF4) release during human platelet aggregation in diabetic patients.


Characteristics of platelet factor 3 release during ADP-induced aggregation. Comparison with 5 hydroxytryptamine release.


Assay of progressive antithrombin in plasma.


A simple technique for the measurement of plasma heparin concentration during anticoagulant therapy.


Rapid detection of fibrinopeptides by bidimensional paper electrophoresis.


Factor XIII assay by an isotope method. II. Heparin inhibition of factor XIII activation.


The kidney and fibrinolysis. A study of aminonucleoside nephrotic rats.


Junction thrombi deposited on conducting materials at different potentials. An electron microscopic study.


Exercise induced increase in split products of fibrinogen.


Platelet adhesiveness, aggregation and fibrinolysis after the oral administration of the contraceptive "Lyndiol".


Blood clotting, plasma kinins and fibrinolysis.


Fibrinolytic activation of plasma by means of urokinase in vitro and in vivo.


Persistence of fibrinolytic activity in fragments of human veins cultured in vitro.


Acidosis induced disseminated intravascular microthrombosis and its dissolution by streptokinase.


Teacher aide attitudes toward the mentally retarded.


Effects noted from the use of the Frostig Training Program with trainable retardates.


Effects of trans-4-aminomethylcyclohexane carboxylic acid as an antifibrinolytic agent on arterial wall and experimental atherosclerotic lesions in rabbits.


Needed: a more realistic classification of mentally retarded children.


Employee perceptions of Daylight Savings Time as it influences job and patients' behavior.


The efficacy of special class placement for the mentally retarded in proper perspective.


A comparison of two groups of mentally retarded children on The Illinois Test of Psycholinguistic Abilities.


Evaluation of the normal and pathologic apexocardiogram on the basis of mathematical analysis.


Changes in the posterior cerebral artery in supratentorial tumors.


Preliminary studies on the prevalence of phosphoglucomutase isoenzymes in the Polish population.


Pathologic jealousy in delusional syndromes.


Monoclonal hypergammaglobulinemia of the gamma M type in a nine-year-old girl with ataxia-telangiectasia.


A new microhemagglutination inhibition pregnancy test.


Creatine kinase in umbilical cord blood.


A semi-micromethod for the determination of serum iron and iron-binding capacity without deproteinization.


Comparison of manual, automated, and "kit" methods for the measurement of glucose and urea in plasma.


Automated micromeasurement of urea using urease and the Berthelot reaction.


Rapid colorimetric method for the quantitative determination of ethchlorvynol (Placidyl) in serum and urine.


Ultrastructure of the kidney in the nephropathy of the nail--patella syndrome.


A scent marking response associated with the ventral sebaceous gland of the Mongolian gerbil (Meriones unguiculatus).


Effects of food depvation and consummatory activity on the heart rate of the rat.


Differential effects of testosterone and oestradiol on male courtship in Barbary doves (Streptopelia risoria).


Light-dependent structural changes in the lamellar membranes of isolated spinach chloroplasts: measurement by electron microscopy.


Two adrenal gland cytochrome P-450 entities evidenced by metyrapone-induced spectra.


Photooxidation of cytochromes in reaction center preparations from Chromatium and Rhodopseudomonas viridis.


The relation of post-illumination ATP formation capacity (X-E) to H+ accumulation in chloroplasts.


Photophosphorylation as a function of light intensity.


Time-dependent quenching of chlorophyll a fluorescence from (pigment) system II by (pigment) system I of photosynthesis in Chlorella.


Contrasting requirement for plastocyanin in the photooxidation of chloroplast cytochromes.


Uncoupling and charge transfer in bacterial chromatophores.


Cytochrome P-450 in adrenal mitochondria of male and female rats.


The role of GSH peroxidase in protecting the membrane of rat liver mitochondria.


The adenine nucleotide translocator and the nucleotide specificity of oxidative phosphorylation.


Simultaneous evaluation of phosphorylation efficiency of the three coupling sites of the respiratory chain in isolated mitochondria.


Evidence from Mossbauer spectroscopy for the role of iron in nitrogen fixation.


Regulation of nitrogenase synthesis by Klebsiella pneumoniae.


The isolation of cytoplasmic polyhedrosis virus from the white-marked tussock moth, Orgyia leucostigma (Smith).


Carbon and nitrogen requirements for macroconidial germination of Fusarium solani: dependence on conidial density.


Effects of Friend leukemia virus on the immune response of mice to bacterial antigens.


Convenient microscopic tests for yeast viability and sporogenic capability.


Cell cycle and post cycle changes during continuous phased growth of Candida utilis.


Mechanism of ammonia production from aspartate in teleost liver.


The coupling of magnesium secretion and sodium reabsorption in the kidney of teleost.


Phylogenetic differences in spontaneous contractility of isolated heart muscle cells.


Comparative effects of temperature on brain enzymes in the goldfish (Carassius auratus) and mouse (Mus musculus).


A comparative study on the influence of temperature on the metabolism of glucose in isolated reptilian and mammalian muscle.


Mechanisms of locomotion in the polychaete, Harmothoë.


Contribution of the pentose cycle to glucose metabolism by insects.


Regulation of sodium and potassium in muscle fibers of the ventricle of Unio, a fresh-water lamellibranch.


Tissue buffering in the snail, Helix aspersa.


Regional distribution of 137Cs in rats forced to swim in warm and cold water.


Serum proteins and haptoglobins of Caribbean rodents.


Effects of temperature on Drosophila. VII. Glutamate-aspartate transaminase activity.


The use of hypnosis in the rehabilitation of complicated vascular and post-traumatic neurological patients.


Theory and practice of pain control in malignancy and other protracted or recurring painful illnesses.


Hypnosis and psychotherapy in dentistry. Five case histories.


Emotional involvement, oral anxiety and hypnosis.


Hypnotically induced amnesia versus ablation of memory.


Hypnosis, hypnotic responsiveness, and learning meaningful material.


Interpretation of patient behavior through goals, feelings, and context.


Birth order of creative writers.

Birth order of creative writers.


Suicide and sibling position.

Suicide and sibling position.


The academic health center--on the rocks with a twist of dilemma.


A healthy university in a sick society?

A healthy university in a sick society?


The role of the social worker in family medicine training.


Curriculum effects on new medical school planning.


Medical school climate: comparative faculty and student views.


Medical school class and illness history.


Teaching behavioral science: an experiment.


Personality correlates of first-year medical school achievement.


Presence and incorporation of glucosamine in a phospholipid fraction of rat brain.


Experience with new curriculum and elective year at Washington University School of Medicine.


Social characteristics of applicants to Canadian Medical Schools.


A second study in composition of small learning groups in medical education.


Glucosamine 6-phosphate deaminase from rabbit erythrocytes.


The core of the matter.

The core of the matter.


Admission of graduate students to the second year of medical school.


A computer-conducted interview for intern applicants.


Basic science departments in the United Kingdom.


State aid to medical schools.

State aid to medical schools.


[Early change of glucose oxidation mode in vivo in mice induced by normobaric or hyperbaric hyperoxia].


[Influence of the nature of dietary sugars on fatty acids of cholesterol esters in rats].


Mass spectrometry of triglycerides. 1. Structural effects.


Mass spectrometry of triglycerides. II. Specifically deuterated triglycerides and elucidation of fragmentation mechanisms.


The absorption of fatty acids by functional bovine mammary cells.


Effects of diets rich in saturated fatty acids with or without added cholesterol on plasma lipids and lipoproteins.


The fatty acids of Entomophthora coronata.


Dietary lipid, fatty acid oxidation and incorporation of carbon into cholesterol.


The variation of triglyceride structure with fatty acid composition in pig adipose tissue.


Metabolic fate of gossypol: the metabolism of 14C-gossypol in rats.


Conditioned appetitive drive states: empirical evidence and theoretical status.


The use of nonlinear, noncompensatory models in decision making.


The mechanical basis of supportive therapy in chronic venous insufficiency. I. The ankle pump.


Physical theory of tension in thick-walled blood vessels in equilibrium.


Strength of collagen fibres obtained from different sources.


Modified marginal zone theory of blood flow through a rigid tube.


Rigidity moduli of bovine fibrin gels initiated by thrombin.


Velocity distribution and other characteristics of steady and pulsatile blood flow in fine glass tubes.


Measurement of capillary resistance by a negative pressure technique and its relationship to buffy layer ascorbic acid levels.


The influence of Vitamin A on condylar,epiphyseal and articular cartilages in the rat.


Loss of vitamins and nutritional studies.


Sources of error in dietary surveys.

Sources of error in dietary surveys.


Dietary ascorbic acid intake of Norwegian students.


Australian dietary surveys with special reference to vitamins.


Dietary surveys on school children and medical students.


Intake of vitamins and some other nutrients in aged people, adults and children.


Vitamin content of the diet and its relation to some biochemical parameters.


Studies on the intake of vitamin C and thiamine among aged people in Finland.


Supply of thiamine and ascorbic acid investigated in aged prople and apprentices living in homes.


Ascorbic acid status of healthy old people.


The induction of keratinization in the corneal epithelium. A comparison of the "dry" and vitamin A-deficient eyes.


Pathogenesis of radiation-induced retinal dysplasia.


Effect of sympathetic stimulation on critical closure of intraocular blood vessels.


Effects of thyroid hormone on the hydroxylation of progesterone in liver microsomes of male and female rats.


Effect of thyroid hormone on the substrate interaction with P-450 in the oxidation of drugs by liver microsomes.


Studies on the respiratory system of Aspergillus oryzae. II. Preparation and some properties of mitochondria from mycelia.


Solubilization, purification and properties of particulate hydrogenase from Desulfovibrio vulgaris.


The structure and function of ribonuclease T1. XI. Modification of the single arginine residue in ribonuclease T1 by phenylglyoxal and glyoxal.


The metabolism of glycoproteins of rat liver microsomes.


Genetically desensitized aspartate kinase to the concerted feedback inhibition in Brevibacterium flavum.


Studies on the substrate specificity of Taka-amylase A. VI. Synthesis of phenyl 2'-O-methyl-alpha-maltoside and an enzymatic investigation.


Turnover of ribosomal RNA of mouse peritoneal macrophages in cell culture.


Structural studies on a glucose containing polysaccharide obtained from Micrococcus lysodeikticus cell walls. I.


Ascorbate synthesizing system in rat liver microsomes. I. Gulonolactone-reducible pigment as a prosthetic group of gulonolactone oxidase.


Depression of respiratory activities by fatty acids in liver mitochondria from diabetic rats and hormonal regulation of mitochondrial fatty acids.


A soluble receptor for estradiol in rat anterior hypophysis.


Nutritional effects on the polyribosome distribution and rate of protein synthesis in Ehrlich ascites tumor cells in culture.


The enzymatic alpha-N-methylation of histidine.


A possible physiological role for glyceroneogenesis in rat adipose tissue.


Urease catalysis and structure. VI. Correlation of sedimentation coefficients and electrophoretic mobilities for the polymeric urease isozymes.


Citrate and the conversion of carbohydrate into fat.  Fatty acid synthesis by a combination of cytoplasm and mitochondria.


Sulfation of sugar nucleotides. II. A particulate sulfotransferase system catalyzing the sulfation of uridine diphosphate N-acetylgalactosamine.


Solubilization and partial purification of protein methylase 3 from calf thymus nuclei.


Stereochemistry of pyruvate kinase, pyruvate carboxylase, and malate enzyme reactions.


Sulfation of sugar nucleotides. 3. Diversity of sulfated sugar nucleotides occurring in hen oviduct.


Stereoselective interactions of phosphoenolpyruvate analogues with phosphoenolpyruvate-utilizing enzymes.


Yeast aldehyde dehydrogenase. 3. Preparation of three homogeneous species.


Yeast aldehyde dehydrogenase. IV. Dissociation and reassociation of native and hybrid forms.


Progesterone-binding components of chick oviduct. I. Preliminary characterization of cytoplasmic components.


The synthesis of acidic nuclear proteins in the prereplicative phase of the isoproterenol-stimulated salivary gland.


The synthesis of isomers of D-apiofuranosyl 1-phosphate.


Structural studies and organic ligand-binding properties of bovine plasma albumin.


The amino acid sequence of hemoglobin V from the lamprey, Petromyzon marinus.


The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria.


Intracellular location and properties of bovine brain sialidase.


Biosynthesis of the alpha chains of collagen studied by pulse-labeling in culture.


Studies on the formation of transfer ribonucleic acid-ribosome complexes. 8. Aminoacyl oligonucleotide binding to ribosomes: characteristics and requirements.


Subunit recycling during translation in a reticulocyte cell-free system.


Pyruvate carboxylase from baker's yeast. The presence of bound zinc.


The hospital service--integration and efficiency.


New unit for disinfecting hyperbaric oxygen chambers.


Transhepatic percutaneous cholangiography.


Studies on syndromes of disseminated intravascular coagulation, in vitro and animal studies.


Electron microscopic study of acute glomerulonephritis in children, with special reference to so-called humps and other deposits.


An antibiotic produced by streptomyces strain No. 2608, identical with D-4-amino-3-isoxazolidone.


Tuberculosis of the esophagus. A case report.


Evaluation of cesarean section hysterectomy as a sterilization procedure.


Free plasma 17-beta-estradiol in normal pregnancy, labor, and the puerperium.


Pyeloureteral dilation and pregnancy.

Pyeloureteral dilation and pregnancy.


Plasma human placental lactogen in late pregnancy and labor.


Hydatidiform moles in other pregnancies of mothers of twins.


Carbohydrate metabolism in experimental intrauterine growth retardation in rats.


Effects of hydralazine on uteroplacental and fetal circulations.


Frequency of pathologic changes in the young human chorion in therapeutic abortions of normal pregnancies. A report on 500 cases studied histologically. 500 chorionic specimens from legal abortions were examined macroscopically and histologically from January 1965 until December 1967.  All 500 specimens were obtained between the fifth and the fourteenth weeks of normal pregnancy.  Among the developmental defects of the chorion, the most frequent finding was focal micromolar degeneration, which was observed in 21% of all cases.  Cases of diffuse involvement of the chorion were found in 2%.  Diffuse micromolar degeneration was observed in 2% of all cases.  Discrete stromal fibrotic changes were evident in 4.4% of the cases, focal intervillous thromboses in 4.2%, fetal "lymphoid" elements in 3.6%, and acute nonspecific inflammations in 1.8%.  Most of the cases in every age group revealed no histopathologic changes at all.  The percentage of abnormal cases rose gradually with the duration of pregnancy.  The changes that did occur were found in the materials from pregnancies taken as "normal".  Since the tissues obtained during therapeutic abortion are not always normal and contain various pathologic changes, the need for systematic microscopic examination of the human chorion is stressed.


Abnormal Papanicolaou smears. Evaluation by colposcopy, biopsies, and endocervical curettage.


Cervical cancer after initial negative and atypical vaginal cytology.


Premature ovarian failure. Report of seven cases.


Significance of abnormal sites of DNA synthesis in certain lesions of the human uterine cervix.


Surgical management of carcinoma of the cervix.


Resting pressure patterns in the nonpregnant human uterus.


Evaluation of peridural anesthesia in outpatient culdoscopy.


Intraureteric pressures in women.

Intraureteric pressures in women.


Male hermaphrodites with female legal sex.


Postgranulomatous epidermoid carcinoma of the vulva.


Acute iron poisoning: obstetrician's opportunity.


Rubella in the distant past as a possible cause of congenital malformations.


Notes on present standing and future developments of angiology.


Forearm venous reflex activity in normal and essential hypertensive subjects.


Revascularization of severe ischemiclegs. Composite reconstruction using semi-closed thromboendarterectomy and tibial artery vein graft.


Multifocal fibrotic diathesis. An often overlooked cause of venae cavae syndrome.


Surgical management of the hypoplastic right heart syndrome.


Controlled production of left ventricular failure in intact calves using implanted coronary occluders.


Results of 271 funnel chest operations.

Results of 271 funnel chest operations.


Daily in vivo functional studies of internal mammary artery implants with metabolic and hemodynamic myocardial alterations.


A simplified surgical approach to therapy of uremic pericarditis with tamponade.


A simplified method of producing experimental heart block.


Intrapericardial pressure and pericardial tamponade in cardiac surgery.


Infarction of a mediastinal neuroblastoma with hemorrhagic pleural effusion.


An unusual complication of balloon-catheter atrial septostomy.


Emergency evacuation of acute pericardial tamponade.


Physiatrist, know thyself.

Physiatrist, know thyself.


Exercise and hypnotherapy in the rehabilitation of the coronary patient.


Influence of cardiac status on rehabilitation of lower-extremity amputees.


Physical rehabilitation of quadriplegic patients.


Participation in household activities as a prognostic factor for rehabilitation.


Shoulder movements during abduction in the scapular plane.


Steroid glucuronyltransferases from the cytosol fraction of human liver.


A protective device for a decubitus ulcer.


Role of endogenous hormones in uterine binding of oestradiol-17-beta.


Metabolic clearance rates and conversions of oestradiol-17-beta in the sheep.


Androgen uptake by rat ventral prostate.


The partial purification of a soluble androgen receptor.


The regulation by methionine of three inducible enzymes in Coprinus lagopus.


Membrane-bound penicillinase of Bacillus licheniformis 749-C.


Methylation of homocysteine in Coprinus lagopus.


Comparative effects of chemical modification on human alkaline phosphatases.


Oestrogen action: a study of the influence of steroid hormones on genetic expression.


Interaction of steroid hormones with histones.


The effect of steroids on transport of electrolytes through membranes.


The preparation of acetylcholinesterase from human erthrocytes.


Oxygenation of methane by methane-grown Pseudomonas methanica and Methanomonas methanooxidans. 1. Experimental conditions have been found in which small amounts of methanol (approximately 2.5mm) accumulated when washed cell suspensions of methane-grown Pseudomonas methanica and Methanomonas methanooxidans were incubated with methane+oxygen mixtures in Warburg flasks. 2. The methanol formed could be separated completely from water by fractional distillation through glass helices followed by gas chromatography using 20% polyethylene glycol 400 on a Celite 545 support. 3. By using (18)O-enriched oxygen gas the abundance of (18)O in the methanol formed from oxidation of methane was measured with a Perkin-Elmer 270 combined gas chromatograph/mass spectrometer. The results showed that the oxygen in methanol was derived exclusively from gaseous oxygen in both micro-organisms. 4. Control experiments using [(18)O]water in incubation mixtures confirmed that there was negligible incorporation of the oxygen atom from water into methanol.


The influence of electrical stimulation in vitro on protein synthesis and other metabolic parameters of rat extensor digitorum longus muscle. 1. Apparatus is described in which rat extensor digitorum longus muscle can be incubated in buffer under conditions of light tension and be subject to contractures induced by electrical stimulation in vitro. Under these conditions the tissue retains its weight, its content of potassium and size of the extracellular space at values similar to those in vivo. 2. Though uptake of glucose was enhanced on addition of insulin, there was little increase in glucose consumption on stimulation. Breakdown of glycogen and enhancement of lactate output were found on stimulation. 3. Incorporation into protein of several labelled amino acids was diminished during stimulation. Accumulation of [(14)C]leucine was enhanced whereas that of glycine was decreased. 4. There were no very consistent changes in the content of free unlabelled amino acids during incubation with or without stimulation. Comparison of actual amino acid concentrations in tissue and incubation mixture with accumulation of (14)C-labelled amino acid indicated that full equilibration of the cell pool of amino amino acids with the medium is slow. 5. Substantial oxidation of several (14)C-labelled acids was observed. 6. The ATP content of the tissue declined a little during incubation and somewhat faster after a period of stimulation. 7. The results are discussed in relation to the way in which exercise can induce muscle hypertrophy.


Quantitative and metabolic changes of hepatic collagens in rats after carbon tetrachloride poisoning. 1. The collagen hydroxyproline in rat liver was composed of 3.5% neutral-soluble collagen, 4.9% acid-soluble collagen and 91.6% insoluble collagen. In labelling studies with [(14)C]proline in vitro, the specific radioactivities of neutral-soluble, acid-soluble and insoluble collagens in rat liver were found to be 233000, 69000 and 830d.p.m./mumol of hydroxyproline respectively after 1h. 2. During subacute carbon tetrachloride poisoning the hepatic content of insoluble collagen markedly increased, whereas those of soluble collagens did not change. During recovery from subacute poisoning hepatic contents of soluble collagens were markedly decreased. 3. After 8 weeks of carbon tetrachloride poisoning the specific radioactivities of hepatic soluble collagens increased, while that of insoluble collagen decreased. During recovery from subacute poisoning, the specific radioactivities of soluble collagens decreased to the normal range and that of insoluble collagen further decreased. 4. Hepatic collagenolytic activity solubilizing insoluble collagen, which differs from mammalian collagenase, decreased under the conditions of the subacute poisoning and also during recovery from subacute poisoning.


Studies on the effect of sulphate nutrition on the flavour components of onion (Allium cepa).


Studies on the phospholipases of rat intestinal mucosa. 1. Subcellular distribution and characteristics of different phospholipases of rat intestinal mucosa were studied. 2. The presence of free fatty acid was necessary for the maximal hydrolysis of lecithin (phosphatidylcholine), but there was no accumulation of lysolecithin (1 or 2-acylglycerophosphorylcholine);lysolecithin accumulated when the reaction was carried out in the presence of sodium deoxycholate and at or above pH8.0. 3. The fatty acid-activated phospholipase B as well as lysolecithinase showed optimum activity at pH6.5, whereas for the phospholipase A it was about pH8.6. 4. The bulk of the phospholipase A was present in the microsomal fraction, whereas the phospholipase B and lysolecithinase activities were distributed between the microsomal and soluble fractions of the mucosal homogenate. 5. Phospholipase A was equally distributed between the brush border and brush-border-free particulate fraction, with the brush border having highest specific activity, whereas the other two activities were distributed between the brush-border-free particulate and soluble fractions. 6. Various treatments showed marked differences between the phospholipase A and phospholipase B activities, but not between phospholipase B and lysolecithinase activities. 7. By using (beta[1-(14)C]-oleoyl) lecithin it was shown that the mucosal phospholipase A was specific for the beta-ester linkage of the lecithin molecule.


Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase. 1. The enzyme that catalyses the transfer of galactose from UDP-galactose to N-acetylgalactosaminyl-(1-->4)-N-acetylneuraminyl-(2-->3)-galactosyl-(1-->4)-glucosylceramide (G(M2)) was found mainly in the heavy- and light-microsomal fractions of the adult frog brain. 2. The subcellular distribution of the enzyme, UDP-galactose-G(M2) galactosyltransferase, parallels that of gangliosides in adult frog brain. 3. The enzymic activity was first detected at late gastrulation (Shumway stage 11(1/2)) and increased until the completion of the operculum (Shumway stage 25) and then decreased in the tadpoles. 4. In adult frog brain, the enzyme exhibited a pH optimum of 7.2-7.3 in both cacodylate and tris buffers. The enzyme required 10mm-Mn(2+) for maximal activity and the K(m) for Mn(2+) was determined as 2.2mm. The half-maximal velocity was obtained at a G(M2) concentration of 0.18mm. Inhibition of the enzymic reaction was found when the G(M2) concentration was greater than 1.38mm. 5. The enzymic activity was also inhibited by the products in the pathway of ganglioside synthesis, i.e. either by a mixture of gangliosides or by individual ganglioside components. The most active inhibitor was disialoganglioside. The degree of inhibition is a function of the individual ganglioside concentration. 6. A product-inhibition mechanism for the regulation of ganglioside biosynthesis is discussed.


Acylation of lysolecithin in the intestinal mucosa of rats. 1. The presence of an active acyl-CoA-lysolecithin (1-acylglycerophosphorylcholine) acyltransferase was demonstrated in rat intestinal mucosa. 2. ATP and CoA were necessary for the incorporation of free [1-(14)C]oleic acid into lecithin (phosphatidylcholine). 3. The reaction was about 20 times as fast with [1-(14)C]oleoyl-CoA as with free oleic acid, CoA and ATP. 4. With 1-acylglycerophosphorylcholine as the acceptor, both oleic acid and palmitic acid were incorporated into the beta-position of lecithin; the incorporation of palmitic acid was 60% of that of oleic acid. 5. Of the various analogues of lysolecithin tested as acyl acceptors from [1-(14)C]oleoyl CoA, a lysolecithin with a long-chain fatty acid at the 1-position was most efficient. 6. The enzyme was mostly present in the brush-border-free particulate fraction of the intestinal mucosa. 7. Of the various tissues of rats tested for the activity, intestinal mucosa was found to be the most active, with testes, liver, kidneys and spleen following it in decreasing order.


The interaction of sulphate esters and glutathione in vivo.


Regulation of lipogenesis. Stimulation of fatty acid synthesis in vivo and in vitro in the liver of the newly hatched chick. 1. A single glucose meal stimulated the incorporation of acetate into fatty acids in liver slices. If the glucose was added in vitro, it had no effect. Fructose and glycerol in vitro markedly stimulated fatty acid synthesis from acetate. Fructose and glycerol probably by-passed a rate-controlling reaction between glucose and triose phosphate. This reaction may have been stimulated by glucose administered in vivo. 2. The stimulation of fatty acid synthesis caused by fructose did not require the synthesis of enzyme, thus indicating that fatty acid-synthesizing enzymes were present in a latent form in the livers from unfed chicks.


Effect of histamine and of bradykinin on incorporation of [14C] leucine by rat liver microsomal fraction.


Oxygenation of methane by methane-utilizing bacteria.


Possible effect of histamine on protein synthesis by the perfused rat liver.


Particulate malate oxidation in strictly aerobic bacteria.


Isoelectric focusing of human liver alkaline phosphatase. 1. Isoelectric focusing of human liver alkaline phosphatase in a sucrose density gradient with LKB Ampholine as carrier ampholytes is described. 2. Problems due to the chelating properties of the ampholytes and the pH gradient were examined. 3. A reactivation procedure to counter these effects was devised that can probably be used for other alkaline phosphatases. 4. The isoelectric point of human liver alkaline phosphatase was found to be pH3.9.


Factors that modify the metabolism of ethanol in rat liver and adaptive changes produced by its chronic administration. 1. 2,4-Dinitrophenol (0.1mm) increases by 100-160% the rate of ethanol metabolism by rat liver slices incubated in a medium saturated with a gas mixture containing O(2)+CO(2)+N(2) (18:5:77). Similar effects are produced by relatively low concentrations of arsenate (10mm). At higher concentrations (37.5 and 50mm) arsenate inhibits the rate of ethanol metabolism. 2. When liver slices are incubated under an atmosphere containing O(2)+CO(2) (95:5) the metabolism of ethanol increases by about 100% over that obtained with O(2)+CO(2)+N(2) (18:5:77). However, under these conditions the activating effect of dinitrophenol is no longer observed. 3. Chronic administration of ethanol to rats for 3-4 weeks, in doses from 3 to 8g/kg per day, increases by 70-90% the ability of the liver to metabolize ethanol. In the liver slices of these rats, although an O(2)+CO(2)+N(2) (18:5:77) mixture was used, dinitrophenol does not further increase the metabolism of ethanol. If the chronic administration of ethanol is discontinued for two weeks, the rate of ethanol metabolism is lowered to control values and the activating effect of dinitrophenol is recovered. 4. No change in alcohol dehydrogenase activity was found in the liver of the rats in which the metabolism of ethanol had been increased as a result of the chronic ethanol treatment; a 40% increase in the activity of succinate dehydrogenase was observed.


Biogenesis of rosmarinic acid in Mentha. The biogenesis of rosmarinic acid (alpha-O-caffeoyl-3,4-dihydroxyphenyl-lactic acid), the second most common ester of caffeic acid in the plant kingdom, was studied in Mentha arvense and Mentha piperita. Administration of (14)C-labelled compounds showed that, whereas the caffeoyl moiety was formed from phenylalanine via cinnamic acid and p-coumaric acid, the 3,4-dihydroxyphenyl-lactic acid moiety was formed from tyrosine and 3,4-dihydroxyphenylalanine. Time-course studies and the use of labelled rosmarinic acid showed that endogenous rosmarinic acid had a low turnover rate. The caffeoyl moiety did not appear to contribute to the formation of insoluble polymers, as has been suggested for chlorogenic acid in other plants.


Multiple activities of penicillin acyltransferase of Penicillium chrysogenum.


Activity of skeletal-muscle ribosomes from intact and castrated rats treated with triamcinolone acetonide.


Dissociation of catalase. A correlation between changes in sedimentation and spectroscopic properties accompanying dissociation of bacterial catalase in alkaline solution. 1. At high concentrations, in 10mm-phosphate buffer, pH7.0, the sedimentation coefficient of bacterial catalase varies with concentration according to: [Formula: see text] with S(0) (20,w)=11.30S and k(s)=6.29x10(-3)ml mg(-1). Sedimentation-equilibrium experiments yield a molecular weight of 240000. 2. Parallel studies of changes in sedimentation-velocity behaviour and in electronic spectra of bacterial catalase at pH>11 were made. Dissociation is indicated by the appearance of a slow-moving (2.9S) component in sedimentation patterns and this is accompanied by marked changes in absorption spectrum in the Soret region. Values of R=E(406)/E(355) show a theoretically predictable near-linear dependence on alpha, the degree of dissociation calculated from ultracentrifuge data. 3. The Soret absorption of bacterial catalase subunits is much lower than that of the native enzyme, and it is suggested that dissociation produces an environmental constraint on the prosthetic group that results in distortion of the porphyrin ring.


Effect of cortisone on transfer ribonucleic acid and aminoacyl-transfer-ribonucleic acid synthetases in rat liver.


The different adsorption of aldolase isoenzymes in rat brain.


Studies on the isolation of epithelial growth factor from fractions of mouse salivary-gland extracts.


Biological effects of epithelial growth factor and its antiserum in neonatal rats.


The histological effects of epithelial growth factor and its antiserum in the neonatal rat.


Indirect evidence that light-induction of adenosine triphosphate hydolysis by cholorplasts depends on electron-transfer reactions.


Preparation of human pathological gamma-macroglobulins by rate zonal centrifugation in BXV Ti rotor.


Extrusion of water in antigen-antibody reactions.


Use of electrofocusing for the detection of carrier proteins and their differention from antibodies.


The circular dichroism of deoxyribonucleic acid and deoxyribonucleohistone and the effect of thermal denaturation.


Countercurrent studies of porcine liver porphyrins.


Effect of bile and pancreatic juice on the absorption of long-chain fatty acids in the sheep.


Base exchange reactions of phosolipid metabolism in chick brain microsomal membranes.


Molecular models for macromolecules: a new concept for teaching and research.


Transport pathway for glycine betaine in rat kidney cortex in vitro.


Transport pathway for glycine betaine in rabbit kidney in vivo.


The effect of circulating lactose on brain metabolism in the neonatal rat.


A flow system for the superfusion and stimulation of isolated mammalian tissues.


Chain-length specificity of inhibition of fatty acid oxidation by pent-4-enoly-L-carnitine and by pent-4-enoic acid.


Characteristics and partial purification of the corticosteroid-binding protein extracted from rat liver.


The effects of various steroids on pentose-shunt dehydrogenase activity.


Inhibition of tryptophan oxygenase in rat liver by steroid hormones.


Enzymic methylation of 2-hydroxyoestrogens to the corresponding 2- and 3-monomethyl ethers by human liver in vitro.


Effect of 2-substituted oestrogens on the enzymic methylation of catecholamines in human liver.


Investigations on the absorption and distribution of trazodone or AF 1161 in rats, dogs and humans.


Skin collagen content and thickness in systemic sclerosis.


Diabetic dermangiopathy.A spectrum including pigmented pretibial patches and necrobiosis lipoidica diabeticorum.


Lymphangioma of skin. A review of 65 cases.


The direction of growth of human epidermis.


Electron microscopic study of the effect of vitamin A on the differentiation of reconstructed embryonic chick skin.


Nail-fold capillary loop development in the infant of low birth weight.


Ultrastructural changes in human skin maintained in organ culture.


Varicella bullosa associated with measles vaccine.


Lipid transport in kwashiorkor.

Lipid transport in kwashiorkor.


Voluntary intake, digestion, rate of passage, amount of material in the alimentary tract and behaviour in cows receiving complete diets containing straw and concentrates in different proportions.


The absorption of alpha-tocopherol in man.


An apparatus for the regulation of the food supply to rats.


The effects of early zinc deficiency on DNA and protein synthesis in the rat.


Effects of zinc deficiency on food intake and feeding patterns of rats.


Changes in the plasma concentrations of free amino acids in relation to egg formation in the hen.


Evaluation of modified [35S] methionine and [35S] casein preparations as supplements for sheep.


Food intake and energy expenditure of army recruits.


Production, absorption, distribution and excretion of vitamin B 12 in sheep.


Metabolism of vitamin E in sheep.

Metabolism of vitamin E in sheep.


A comparison of markers for estimating magnitude of rumen digestion.


The urinary aromatic acids excreted by sheep given S24 perennial ryegrass cut at six stages of maturity.


The effect of dietary essential fatty acids on the concentration of serum and liver lipids in the rat.


Blood urea measurement as a technique for assessing protein quality.