Pathogenesis of contrast media injury: insights provided by neurotoxicity studies.


Transition metal complexes of porphins, corrins and related compounds.


Solid 'liquid-crystalline' films of synthetic polypeptides: a new state of matter.


Trends in preparation of new angiographic contrast media with special emphasis on polymeric derivatives.


Excretory pathways for contrast media.

Excretory pathways for contrast media.


Chemical composition and names of some principal water-soluble and cholecystographic contrast media.


Circulatory effects of repeated intraarterial injections of Conray 60.


Hemodynamic responses to contrast media.


Effects of angiographic contrast media and hypertonic saline solutions on cerebral venous outflow in autoregulating brains.


Particulate radiographic contrast material for quantitative representation of blood-flow patterns. I. Experimental studies.


Contrast-protein interactions.

Contrast-protein interactions.


Improved technique for production of particulate contrast medium.


Osmotic properties of some contrast media.


Pursuit of the pits in the nevoid basal cell carcinoma syndrome.


Pilosebaceous dysplasia in the oral-facial-digital syndrome.


Pityriasis rubra pilaris. Prolonged treatment with methotrexate.


Yellow nails. A report of six cases.

Yellow nails. A report of six cases.


Evaluation of possible chronic hepatotoxicity from methotrexate for psoriasis.


Dermatitis of hands and feet associated with intestinal malabsorption in B.itish service families in Singapore.


Dermatitis associated with an implanted cardiac pacemaker.


Ikeda S: Sturge-Weber and Klippel-Trénaunay syndrome with nevus of ota and ito.


Nevoid basal cell carcinoma of the palm.


Vamp disease. Inflammation of the great toe due to pressure from women's shoes.


Psoriasis and systematized epidermal nevus.


Verrucose sarcoidosis.

Verrucose sarcoidosis.


Lung abscess. Complication of high dosage steroids in bullous pemphigoid.


Chalazion clamp for dermatological surgery.


Psoriasis.

Psoriasis.


Molluscum contagiosum.

Molluscum contagiosum.


Sulfones.

Sulfones.


Health policies for the 70's. Walter J. Zeiter Lecture.


Discrimination of time interval between cutaneous stimuli in normal and hemiplegic subjects.


Walking patterns of normal women.

Walking patterns of normal women.


Stroke in a midwestern county.

Stroke in a midwestern county.


An experimental and clinical appraisal of "syncardial" compression.


Effect of liner materials on interface pressures in below-knee prostheses.


A factor inactivating in vitro transforming DNA isolated from transformable group H streptococci and its relation to competence of the cells.


Control of ornithine-transcarbamylase formation in aspergillus nidulans.


The effect of hypothermia on the respiratory response to carbon dioxide.


Gertel M: An evaluation of two new local anaesthetics for major conduction blockade.


Effect of gallamine on cholinergic receptors.


Electrocardiographic changes associated with the use of epinephrine during general anaesthesia.


The effects of inhalation anaesthetic agents on convulsant (LD-50) doses of local anaesthetics in the rat.


The preparation of accurate standard mixtures of inhalation anaesthetic agents.


Anaesthetic dosage for epidural sympathetic blockade.


Adsorption of halothane vapour in glass syringes.


Epidemiology, diagnosis and control of leptospirosis in man.


Rare complication during stellate ganglion block: a case report.


Halothane sensitization: a case report.

Halothane sensitization: a case report.


Haematoma following epidural anaesthesia.


The published image.

The published image.


Borosilicate glass rods for living tissue illumination.


Use of membrane mirrors in surgical photography.


A report on educational programs in biophotography sponsored by the Biological Photographic Association.


A statement on the internship program in the biomedical photography curriculum.


A new consideration in electron microscopy.


Support for research, training and education in medical research engineering.


Engineering R&D support by the hospital and university.


A cardiac response demonstrator useful in teaching pacemaker function.


Legislation. Device inventory and classification.


An evaluation of methods for determining the concentration of fibrinogen in rabbit plasma.


Identification of the hexosamine linked to hydroxyaminoacids in the protein-polysaccharide linkages.


Human chorionic somato-mammotropin (HCS): effects on glucose metabolism in rat epididymal adipose tissue.


The dynamic response of a photoreceptor.


Quantitative data in neuroanatomy.

Quantitative data in neuroanatomy.


Applications of computer simulation to the study of neurochemical behavior.


General principles of simulation techniques.


Muscle AMP aminohydrolase. IV. Purification of rat muscle enzyme.


Computer programming for parameter analysis of the electroencephalogram.


Brain-computer relationships.

Brain-computer relationships.


Estimation of the parameters of a truncated gamma distribution in the case of neuronal spike data.


On-line cfmputation in behavioral neurophysiology.


The quantitative analysis of EEG data.

The quantitative analysis of EEG data.


Quantitative computer analysis of intracellularly recorded action potentials.


The use of correlation analysis in processing neuroelectric data.


Computers of the brain and brainmade computers.


Blindness in St. Lucia.

Blindness in St. Lucia.


Some biological observations on hypoglycin-A in the presence of leucine.


The clinical features in adults sickle cell anaemia in Jamaica.


Slipped capital femoral epiphysis.

Slipped capital femoral epiphysis.


Some features of infantile malnutrition in Jamaica.


A note on infant feeding in Kingston.

A note on infant feeding in Kingston.


Kaposi's sarcoma in West Indians.

Kaposi's sarcoma in West Indians.


A comparison of the in vitro sensitivity of Furadantin and Nalidixic acid (Wintomylon) on urinary pathogens.


The "Uroscreen" test for significant bacteriuria in pregnancy.


The young primigravida.

The young primigravida.


The problems of grand multiparity.

The problems of grand multiparity.


A study of the movement and location of U.W.I. medical graduates, classes 1954-1965.


Management of orthopaedic problems from the 1962 epidemic of poliomyelitis in Guyana.


Direct titrimetric microdetermination of threonine. I. Direct determinations of threonine-L-arginine and L-histidine-threonine-L-arginine mixtures without separating.


A survey of twins in the population of a prospective collaborative study.


Genetic criteria for the classification of malformations--a twin study.


Congenital malformations in MZ twins.

Congenital malformations in MZ twins.


Thalidomide-embryopathy in twins: a collaborative study.


Conjoined twins--a genealogical study.

Conjoined twins--a genealogical study.


Twins with clefts.

Twins with clefts.


Twinning and blood groups. I. ABO frequencies in twins and controls: immunological considerations.


The role of Xg a blood group incompatibility in fetal loss--twin study.


Allergy and disease in twins: an anamnestic study.


The genetic control of blood pressure under experimental stress.


Twin studies in congenital heart diseases.


Coronary occlusion in twins.

Coronary occlusion in twins.


The twin clinical method in dermatology.


Concordant glaucoma in MZ twins.

Concordant glaucoma in MZ twins.


Family studies of MZ twins discordant for schizophrenia: neurological findings.


A twin study of suicide.

A twin study of suicide.


Twins with mental retardation and physical abnormalities: preliminary report.


Twenty-one psychiatric cases and their MZ cotwins. A thirty years' follow-up.


Do conception delays explain some changes in twinning rates?


A twin register for eye studies and need for collaboration.


The inheritance of DZ twinning. A study of 18,737 maternities in Ibadan, Western Nigeria.


Placental forms and zygosity determination of twins in Ibadan, Western Nigeria: a study of 1,475 twin maternities.


Leukemia in twins: world-wide review of clinical cases.


Cancer in twins: concordance or discordance?


Some considerations about twin zygosity and concordance determination in cancer research.


Cancer in MZ and DZ twins.

Cancer in MZ and DZ twins.


Fetal acidosis in second twins.

Fetal acidosis in second twins.


Changes in maternal body composition resulting from twin pregnancies.


Leukocytic infiltration of the umbilical cord in twins.


Influence of serum cholesterol level of parents on litter size in Swiss albino mice.


Nosocomial colonization with kanamycin-resistant Klebsiella pneumoniae, types 2 and 11, in a premature nursery.


A study on evaluation of selected general anaesthetics in buffalo calves.


Factors influencing toxicity of bilirubin in cerebellum tissue culture.


Hereditary tyrosinemia and abnormal pyrrole metabolism.


The nonoperative treatment of meconium ileus by Gastrografin enema.


Survival of infants with severe congenital heart disease.


Progressive hydronephrosis, hydroureter, and dilatation of the bladder in siblings with congenital nephrogenic diabetes insipidus.


The hemolytic process of viral hepatitis in children with normal or deficient glucose-6-phosphate dehydrogenase activity.


Chromosome aberrations in 50 patients with idiopathic mental retardation and in 50 control subjects. Madison blind study 3.


Management of supraventricular tachycardia by atrial stimulation.


Primary idiopathic segmental infarction of the greater omentum.


Neonatal thrombocytopenia and congenital malformations associated with administration of tolbutamide to the mother.


The value of fetal scalp blood hemoglobin determination in Rh erythroblastosis fetalis.


Arginine-induced growth hormone responses in children: effect of age and puberty.


Effect of adolescence on the serum growth hormone response to hypoglycemia.


Identification of heterozygous genotype for cystinosis in utero by a new pulse-labeling technique: preliminary report.


Cyanosis of the newborn infant. Recognition and clinical evaluation.


Respiratory failure in a full-term infant.


Possibility of cystic fibrosis in infants with vitamin K deficiency.


Anticonvulsants and hemorrhagic diseases of the newborn infant.


Some thoughts and speculations on breast-feeding.


"Mucosa to skin" loop colostomy.

"Mucosa to skin" loop colostomy.


Axillary-femoral bypass grafts for aorto-iliac occlusive disease.


Stricture formation after end-to-end trachea repair in goats.


The management of acute cholecystitis.

The management of acute cholecystitis.


The value of radical neck dissection in the treatment of cancer of the head and neck.


Injuries of the common bile duct.

Injuries of the common bile duct.


Toxic megacolon--experience with 5 cases in the S. Transvaal.


An evaluation of the Cyprane Trilene inhaler.


Gastric inflation due to artificial respiration.


Aggregation of erythrocytes in ACD-blood after dilution with isotonic glucose solutions.


Ventilatory and circulatory effects of anaesthesia and cardiopulmonary bypass.


Pinocytic uptake of ferritin by the amoeba Chaos chaos measured by atomic absorption of iron.


The degradation of the B-chain of oxidized insulin by Mucor miehei protease.


Hydrogen isotope exchange of insulin. A comparison of methods.


Cytolysomes in Tetrahymena pyriformis Gl. II. Reversible degeneration.


Evidence for a common transport system for a group of amino acids in Tetrahymena.


The president's page.

The president's page.


Liability for use of paramedical personnel.


Malpractice--a review of 174 claims.

Malpractice--a review of 174 claims.


The medicolegal autopsy.

The medicolegal autopsy.


Professional continuing education--and deductibility of related travel expense under the U.S. income tax code.


The Connecticut confidentiality statute.


Effect of gibberellic acid on elongation and nucleic acid synthesis in etiolated Alaska pea epicotyl.


Chemical nature of yeast sexual hormones.


Effect of yeast sexual hormones on elongation of Avena coleoptile.


Ultrastructural nuclear and nucleolar lesions induced by 1-nitro-9-aminoacridine in rat liver cells.


Ultrastructural lesions induced by 1-nitro-9-aminoacridine in the cytoplasm of rat liver cells.


Quantitative changes of nucleic acids in lymphocytes in culture under the influence of amethopterin.


Morphological and histoenzymatic features of mouse brain gliomas induced by methylcholantrene.


The blood groups of the Newars of Nepal.


The comparison of somatic development, body composition and functional characteristics in Tunisian and Czech boys of 11 and 12 years.


Skinfold thickness and body fat in children.


Skeletal maturation of the hand and wrist in Jamaican children.


A comparison of skinfold measurements using the Best and Harpenden calipers.


A high incidence of multiple births in one area of New Britain.


Selective differentiation of the ABO blood group gene frequencies in Europe.


Genetic problems of hot desert populations of simple technology.


Studies on the control of bacterial stalk rot of maize with antibiotics.


The impact of high altitudes on human populations.


In vitro effect of antibiotics and fungicides against Pseudomonas pisi, the incitant of bacterial blight of pea in Udaipur, Rajasthan.


Effect of actinomycin-D & chloramphenicol on the deposition of glycogen in the developing oocytes of Delias eucharis Drury (Pieridae-Lepidoptera, Insecta).


In vitro effect of antibiotics and fungicides on Rhizobium species from guar.


Effect of altered hormonal states on histochemical distribution of proteins in the rat prostatic complex.


Autoradiographic studies on DNA synthesis in sex chromosomes of five-striped squirrel, Funambulus pennanti Wroughton.


The extent of participation of electrostatic forces in antigen-antibody interactions.


Changes in amino acid metabolism in rat brain following glycosine administration.


Study of epididymal function following long-term treatment with isomers of clomiphene citrate.


Monoamine oxidase activities in tissues of experimental atherosclerotic rabbits.


Efficacy of acti-dione and aureofungin in the control of post-harvest decay of some cucurbitaceous fruits due to Pythium apharnidermatum.


Role of sodium-retaining hormones in cardiac control.


Experimental chemical nephritis in canines: some diagnostic aspects.


Serum protein patterns in experimental candidiasis.


Enzyme degradation of conidial wall during germination of Neurospora crassa.


Genetic investigation of tryptophan-requiring mutants of Aspergillus nidulans.


Nature of antiviral activity detected in some plant extracts screened in cell cultures infected with vaccinia & Ranikhet disease viruses.


Biological effects of high background radioactivity: studies on plants growing in the monazite-bearing areas of Kerala coast & adjoining regions.


A-435-a new antifungal agent.

A-435-a new antifungal agent.


Modifying effect of pre- & post-treatment with nitrogen mustard on the effect of UV irradiation in Aspergillus chevalieri (Mangin).


Regionalization of the physiological effect of mistletoe infection.


Quantitative in vitro titration of anti-lymphocyte serum.


Effect of papain on hepatic lipids in experimentally induced fatty liver.


Effect of paraldehyde on lung surfactant.


Application of calcium arsenate: histopathological changes & glycogen mobilization in Achatina fulica bowdich.


Effect of betamethasone on strophosid induced ventricular fibrillation in guinea-pigs.


Distribution of blood potassium & haemoglobin types in Indian sheep.


Non-specific sensory input from the eyes of scorpion, Heterometrus fulvipes.


Chloride dependent growth stimulation of Vibrio cholerae (569B Inaba).


Studies on aflatoxin synthesis in Aspergillus flavus.


Chemical investigations of plant tissues grown in vitro: isolation of beta-sitosterol from Morus alba (Mulberry) callus tissue.


Physiology of sorghum spikelets infected by Sphacelia sorghi: effect on phenolics & polyphenol oxidase.


Defective bacteriophages.

Defective bacteriophages.


The molecular biology of Reovirus.

The molecular biology of Reovirus.


From cell biology to immunology--a short trip.


The distribution of rapidly hybridizing RNA sequences in heterogeneous nuclear RNA and mRNA from HeLa cells.


Differential temperature sensitivity of normal and cancer cells in culture.


Biosynthesis of the alpha chains of collagen.


Modification of rabbit muscle aldolase in vivo and in vitro.


Cytotoxic effects of puromycin on the Golgi apparatus of pancreatic acinar cells, hepatocytes and ameloblasts.


Microbody formation in regenerating rat liver.


A heme-peptide as an ultrastructural tracer.


Non-osteogenic fibroma of bone.

Non-osteogenic fibroma of bone.


Reaction in the tissues of the carpal tunnel after repeated contractions of the muscles innervated by the median nerve. An experimental investigation on the rabbit.


Post-fracture growth changes in rats.

Post-fracture growth changes in rats.


Tumoral lipo-calcinosis.

Tumoral lipo-calcinosis.


Dysphagia and dyspnoea as complications in spondylarthritis ankylopoetica with cervical osteophytes.


Bilateral Sprengel's syndrome with situs inversus totalis.


Trigger finger. Incidence in children and adults and the possibility of a predisposition in certain age groups.


Operation for Dupuytren's contracture by the method of McCash.


Surgical treatment of flexion-adduction contracture of the thumb in cerebral palsy.


Operative adaptation with cerclage in traumatic rupture of the symphysis.


Leg lengthening.

Leg lengthening.


Central dislocation of the hip. The prognosis with conservative management.


Fusion of the knee joint with internal fixation by staples. A preliminary report.


A new, adjustable iron cross bar to be used in plaster casts.


A new brace for the treatment of congenital clubfoot.


Training.

Training.


Combined therapy for cancer of the laryngopharynx.


Experimental microembolization of cochlear vessels.


Vocal-cord paralysis with endotracheal intubation.


Concept of mechanical assist in esophageal speech.


Tympanometry in human temporal bones.

Tympanometry in human temporal bones.


Tympanometry.

Tympanometry.


Malignant change in sphenoid sinus fibrous dysplasia.


Thorium-dioxide granuloma with laryngeal palsy.


Roentgenographic changes in healed meningococcal labyrinthitis.


Paroxysmal positional vertigo in vitamin B12 deficiency.


Hemangioma of the pharynx in a newborn.

Hemangioma of the pharynx in a newborn.


Fixation of Foley catheter against external naris.


Repeated aspiration of multiple hypodermic needles.


Intracranial tumours in children.

Intracranial tumours in children.


Uric acid levels in serum and C.S.F. in neurological disorders.


A clinical study of 100 patients with poliomyelitis.


Serum tocopherol levels in normal children.


Serum transaminase levels in various childhood disorders.


Pyelonephritis.

Pyelonephritis.


Leucocyte culture with bean extract and AB serum for chromosome analysis.


Niemann Pick disease.

Niemann Pick disease.


Congenital diaphragmatic hernia.

Congenital diaphragmatic hernia.


Pediatric cholera.

Pediatric cholera.


Three cases of fundus flavimaculatus.

Three cases of fundus flavimaculatus.


The effects of autonomic nervous system agents on vitamin B6 and amine metabolism in rabbit brains.


The Trueta phenomenon.

The Trueta phenomenon.


Alkaline phosphatase in neutrophil leucocytes in infectious diseases.


IUPAC-IUB Commission on Biochemical Nomenclature (CBN). Abbreviations and symbols for nucleic acids, polynucleotides and their constituents. Recommendations 1970.


Circular dichroism of DNA.

Circular dichroism of DNA.


Carbohydrate components of extraneuronal gangliosides from bovine and human spleen, and bovine kidney.


Preliminary partial purification of hen liver microsomal stearoyl-CoA desaturase.


Effects of trialkyltin and triphenyltin compounds on mitochondrial respiration.


Binding of aldolase and triosephosphate dehydrogenase to F-actin and modification of catalytic properties of aldolase.


Studies on human erythrocyte IMP: pyrophosphate phosphoribosyltransferase.


The incidence and treatment of faucial diphtheria in a rural West Bengal population.


A study of diphtheria cases among hospital admissions in Calcutta during 1969.


Aetiopathogenesis of bronchiectasis. (An analysis of 53 cases).


Spontaneous pneumothorax.

Spontaneous pneumothorax.


Angiography in renal disease.

Angiography in renal disease.


Diphtheria--a health problem in India.

Diphtheria--a health problem in India.


Radioimmunoassay of Australia antigen.

Radioimmunoassay of Australia antigen.


The logarithmic growth of the human mandible.


Development of the intermediate lobe of the rat pituitary and differentiation of its cells.


A conceptual basis of viral hepatitis.

A conceptual basis of viral hepatitis.


The glands of the common bile duct in the rat and mouse. An electron microscope study.


Electron microscopy of hepatitis associated antigens.


Curvature of the heart: its first appearance and determination.


Australia antigen in patients with acute and chronic liver disease, in blood donors and recipients.


Hemophilia, hepatitis and HAA.

Hemophilia, hepatitis and HAA.


Solitary cyst of the ramus ossis pubis. Report of a case.


Au-SH-antigen in liver disease.

Au-SH-antigen in liver disease.


The age distribution of hepatitis-associated antigen (HAA) in Switzerland.


A study of prevalence and biosocial variables in mental illness in a rural and an urban community in Uttar Pradesh--India.


Plasma concentrations of thioridazine in patients with depression. A preliminary report.


Interest of enzymatic determinations: OCT, GOT, GPT and observations of the presence of Australia antigen relating to viral hepatitis in blood donors.


HAA-antigen determination in 12,000 patients in a general Copenhagen hospital.


A controlled study of the antidepressant effect of p-Chloro-N-methylamphetamine, a compound with a selective effect on the central 5-hydroxytryptamine metabolism.


Attitude of educated Nigerians to psychiatric illness.


Some observations concerning the "pink spot" reacting substances in urine.


Two cases of "folie à deux" in husband and wife.


Cerebro-organic pathogenesis in 110 children followed-up subsequent to admission to a child psychiatric department.


Recalcification of bone metastases by calcium diorotate.


Effect of potassium and tris-aspartate on heparin-induced serum free-fatty-acids evaluation, in man.


New horizons in gastrointestinal physiology.


Effect of concurrent treatment with terramycin and streptonigrin on Rauscher virus in BALB-c mice.


Embryonal rhabdomyosarcoma (sarcoma botryoides) of the middle ear.


The ultrastructure of Kaposi's sarcoma.

The ultrastructure of Kaposi's sarcoma.


[Surgical treatment in cardiac localizations of bacterial endocarditis].


Burkitt's tumor. A cytologic and histological study of three cases.


The role of the thalamus (VL) and pallidum in the activation of motor functions.


Enzymes of dopa metabolism of diencephalic structures in man and rabbit with special regard to extrapyramidal disorders.


Sensory function of the pulvinar.

Sensory function of the pulvinar.


Remarks concerning the effect of diencephalic lesions on pain and sensitivity with special reference to lemniscally mediated control of noxious afferences.


Neuroleptanesthesia--a new method of anesthesia for transphenoidal cryohypophysectomy.


The advantage of ventricle decompression.


Steroid abnormalities in psychomotor epilepsy.


The primary female register transition in singing. Aerodynamic study.


Pitch perturbations in normal and pathologic voices.


The results of vocal organ investigations of the deaf.


Apple peel small bowel: an uncommon variant of duodenal and jejunal atresia.


Unoperated funnel chest in middle and advances age: evaluation of indications for operation.


Incidence of diabetes in families of patients with Hirschsprung's disease.


Ureteroneocystostomy in refluxing ureteric duplication: indications, technique and results.


Postoperative intensive care of esophageal atresia patients.


Experience with gastrografin enema in the treatment of meconium ileus.


Multiple intestinal atresias.

Multiple intestinal atresias.


Esophageal atresia associated with an anorectal anomaly and probably laryngeal fissure in three siblings.


Use of optic pantograph to reduce transversal tomograms to normal size.


The survival of 51Cr-labeled erythrocytes in dependence to the dose of whole-body x-irradiation.


Neural control of contracture in slow muscle fibres of the frog.


Prolonged coumadin treatment as an adjuvant to surgery in an experimental colon carcinoma.


Heterosegmental contralateral inhibition in the sacral cord of the cat.


Potassium- and sodium- induced changes in the electrical activity of heart cells "in vitro".


Enzymatic and ultrastructural changes in subcellular fractions from developing rat brain.


Relationship between plasma erythropoietin activity and hematocrit ratio in high altitude residents.


Effect of the local application of anti-cerebral immune-serum on the electrical activity of the thalamus and neocortex of the rat.


Bronchogenic carcinoma. Anatomical and physiological conditions of its origin and evolution.


On the validity of some Indian species of the genus Spinitectus, Fourment, 1883, with a key of the Indian species.


Hygromycin-B induction of trichomoniasis in pigeons (Columba livia).


Fowl cholera: immune response in turkeys.


A comparison of radiographic lesions in pelvic limbs of chickens infected with Mycoplasma gallisepticum, Mycoplasma synoviae, or an arthritis-producing virus.


Effect of avian influenza-A viruses upon egg production and fertility of turkeys.


Immunization against Mycoplasma gallisepticum.


Effect of novobiocin on fowl cholera in turkeys.


Efficacy evaluations of robenzidene for control of coccidiosis in chickens.


Microtitration of Salmonella pullorum agglutinins.


The effects of in vivo light and temperature acclimation on in vitro responses of heart rate to temperature in a cold-climate reptile, Thamnophis sirtalis parietalis.


Oxygen consumption of largemouth bass, Micropterus salmoides, in relation to swimming speed and temperature.


Erythropoiesis through clone cell formation in peripheral blood of the white sucker, Catostomus commersoni, studied after labeling with 3H-thymidine for various exposure intervals.


A morphological comparison of two closely related species of the genus Myoxocephalus (Pisces: Cottidae) with notes on their life histories and ecology.


Chromatin patterns in fishes with emphasis on sexual dimorphism.


Taenia macrocystis (Diesing, 1850), its occurrence in Eastern Canada and Maine, U.S.A., and its life cycle in wild felines (Lynx rufus and L. canadensis) and hares (Lepus americanus).


Temperature selection in day-old chickens (Gallus domesticus) and young Japanese quail (C. coturnix japonicus).


The effect of age on the thermal preference of white mice (Mus musculus) and gerbils (Meriones unguiculatus).


Observations on the opisthonephric kidney of the sea lamprey of the Great Lakes, Petromyzon marinus L., at various stages during the life cycle.


The trypanosomes of Ranidae. II. The effects of excitation and adrenalin on the peripheral parasitaemia in the bullfrog (Rana catesbeiana Shaw).


A histological and histochemical study of the development of the pineal gland in the chick, Gallus domesticus.


Effect of pituitary homotransplants on peripheral target organs in intact threespine sticklebacks, Gasterosteus aculeatus L. form trachurus.


Muskox (Ovibos moschatus) milk. I. Gross composition, fatty acid, and mineral constitution.


Studies on the band-tailed pigeon (Columba fasciata) in British Columbia. 1. Seasonal changes in gonadal development and crop gland activity.


Snowshoe hare (Lepus americanus) milk. I. Gross composition, fatty acid, and mineral constitution.


Small chamber tests of insecticidal fumigants.


Locomotor activity responses in juvenile sockeye salmon, Oncorhynchus nerka, to melatonin and serotonin.


A technique for collecting ectoparasites from small birds and mammals.


Variation in ruminal nitrogen levels among some cervidae.


Nest digging behavior of rainbow trout (Salmo gairdneri).


Neural origin of cardioperiodicities in Limulus.


The presence of pteridines in the hypodermis as a taxonomic tool in crayfish.


A study of plasma fibrinogen content and its fibrinolytic activity in acute cerebral infarction.


Some observations on thrombolysis in vitro. An alternative hypothesis on fibrinolytic mechanisms in thrombolysis.


Inter-relationship of serum uric acid and serum cholesterol in cases of coronary artery disease.


Value of blood pyruvic acid estimation in evaluation of myocardial infarctionand renal disease.


Study of platelet adhesiveness and serum lipids in cerebral venous-venous sinus thrombosis during puerperium.


Elective countershock in atrial fibrillation with an intracardiac electrode--a preliminary report.


Atherosclerosis in the aged: a postmortem study.


Potentiation of lipogenic action of insulin by epinephrine observed in normal and maturity-onset diabetic individuals.


Plasma free insulin-like activity in normal and diabetic subjects.


Acute intermittent porphyria as a diagnostic problem. (A case report from Punjab).


The incidence and distribution of pigmented naevi in Indians.


Hypogammaglobulinemia in an adult female.


Lower extremity paralysis complicating herpes zoster.


The influence of motor activity and sensible excitation on the regional spinal blood flow.


The effect of CSF on blood clotting.

The effect of CSF on blood clotting.


Massive dural sinuses occlusion, including a dilated straight sinus, in hydrocephalic infant. A case report with detailed angiographic studies.


Syndromes of dwarfism and obesity associated with prediabetes.


Serum lipids in diabetic children.

Serum lipids in diabetic children.


Growth as a measurement of control in the management of diabetic children.


The genetics of diabetes.

The genetics of diabetes.


Some aspects of growth in diabetic children.


Growth attainments of juvenile diabetics.


Residential care of the diabetic child.

Residential care of the diabetic child.


A special Bar Mitzvah.

A special Bar Mitzvah.


The Reikian method in psychoanalysis.

The Reikian method in psychoanalysis.


Theodor Reik: letters to a student.

Theodor Reik: letters to a student.


The resolution of a delusional hair fetish.


Puerilism.

Puerilism.


Avoidance of tenderness.

Avoidance of tenderness.


Ego development and the hypnosis theory of schizophrenia.


Hamlet: a psychoanalytic reinterpretation.


Dybbuks and their divines.

Dybbuks and their divines.


The Sda blood group antigen in tissues and body fluids.


Four examples of Bhm blood in one family.


Anticoagulants.

Anticoagulants.


Some data on the low frequency antigens Wra and Bpa.


Additional uses of blood group A substance from peptone.


A method for the preservation of human blood group erythrocyte antigens in liquid nitrogen for a test cell panel.


Anti-A hemagglutinin from the garden snail Euphadra periomphala: inhibition by N-acetyl-D-galactosamine and N-acetyl-D-glucosamine.


Steroid assays in human pregnancy blood.


The human isolated cervix: a study of its spontaneous motility and responsiveness to drugs.


Restless legs.

Restless legs.


Osteoporosis, skin collagen, and androgen. Total skin collagen was found to be decreased in untreated patients with osteoporosis, particularly women, but increased after treatment with androgens in women. Decreased body collagen may possibly be a primary defect in osteoporosis, while androgens may increase total skin collagen.


The lateral respiratory neurones of the medulla: their associations with nucleus ambiguus, nucleus retroambigualis, the spinal accessory nucleus and the spinal cord.


Ascending projections of the medial cerebellar (fastigial) nucleus: an experimental study in the cat.


Automated method for determination of serum calcium by use of alizarin.


Improved nitromethane-hyamine method for the chemical determination of nitrofurantoin in whole blood.


Ammonium sulfate precipitation of conjugated estrogens in pregnancy urine: rapid assay and glucose effects.


Comparison of serum lithium determinations by flame photometry and atomic absorption spectrophotomerry.


Progesterone in nonpregnancy plasma. An assay method for the clinical chemistry laboratory.


Preservation of urine for ammonia determination with a direct method.


Chest trauma.

Chest trauma.


Jaw depression elicited by tooth pulp stimulation.


Ostertagia circumcincta: methyridine and tetramisole against third stage larvae.


Trichinella spiralis: fine structure of body wall with special reference to formation and moulting of cuticle.


Antitumor activity of imidazole derivatives, especially of 2',3',5'-tri-o-formyl beta-D-ribofuranosyl 5-formamido 4-imidazolethiocarboxamide.


Radioautographic study on the distribution of a polysaccharide with antitumor activity in mice.


Establishment of four lines of transplantable rat leukemia induced by N-nitrosobutylurea in Donryu rats.


The synthesis of a di-N-acetylchitobiose asparagine derivative, 2-acetamido-4-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-1-N-(4-L-aspartyl)-2-deoxy-beta-D-glucopyranosylamine.


Adenylate kinase from bakers' yeast. IV. Substrate and inhibitor structurll requirements.


Low temperature circular dichroism of tyrosyl and tryptophanyl diketopiperazines.


Induction of phenobarbital of microsomal mixed oxidase enzymes in regenerating rat liver.


Biosynthesis of a mycobacterial lipopolysaccharide. Properties of the polysaccharide methyltransferase.


Reactions at the 3' terminus of transfer ribonucleic acid. A single enzyme catalyzes the incorporation of adenosine monophosphate and cytidine monophosphate into transfer ribonucleic acid.


"Do doctors cheat more than anybody.

"Do doctors cheat more than anybody.


Whats new and different on this year's tax return.


Chronic proximal spinal muscular atrophy.


Dear Juli, Dealing with the delinquent patient.


How to get 20 per cent more mileage from your car deductions.


Regeneration of muscle in Duchenne muscular dystrophy: an electron microscope study.


Cracking up over collision insurance costs?


Dental materials in Japan 1969-1970.

Dental materials in Japan 1969-1970.


Conservative dentistry in Japan 1969-1970.


The effect of an intrauterine thread on tissue changes in the endometrium of the pseudopregnant rat. 1. Changes in the fresh weight of uterine horns bearing unilateral intrauterine threads have been measured during early pseudopregnancy in the rat.2. Such a thread, which acts as an intrauterine contraceptive device, causes an increase in weight in the horn which carries it, compared to the untreated contralateral horn, on days 2, 4, 5 and 7 of pseudopregnancy. This increase is observed when the device has been present either for 25 or for 45 days.3. The fresh and dry weights of samples of endometrial tissue together with the concentration of chloride and potassium in these samples have also been determined, both in control horns and in horns which have contained a device for 45 days.4. The fresh and dry weights of samples from the device side are greater than the control. However, the weights of the endometrial samples recovered showed considerable variation, particularly in the device side. The weight of water per unit dry weight of endometrial tissue remains constant in the control side but falls steadily from day 2 to day 7 in the device side. The extracellular fluid space, as measured by the weight of chloride per unit dry weight, follows a similar pattern in each side. The weight of potassium per unit dry weight of control tissue falls on days 4 and 5 but rises again on day 7. By contrast, the potassium content of endometrial tissue from the device side falls steadily, reaching its lowest value on day 7.5. These results suggest that the presence of an intrauterine thread alters the composition of the connective tissue matrix of the uterine endometrium. It is likely that these changes are partially responsible for the contraceptive action of such a foreign body.


Effects of iontophoretically applied drugs on spinal interneurons of the lamprey. 1. Intracellular records were obtained from giant interneurones in the isolated spinal cord of the sea lamprey. The cells had a mean resting potential of about 75 mV and action potentials with overshoots of about 35 mV. Their input resistances, measured by passing polarizing currents through the recording pipette, were in the range 3-7 MOmega.2. Iontophoretic ejection of gamma-aminobutyric acid (GABA) from a micropipette placed near the surface of a cell resulted in a slight hyperpolarization, accompanied by a marked reduction in input resistance. The reversal point for the potential change was about 5 mV greater than the resting membrane potential.3. Iontophoretic application of L-glutamate to the cells produced a depolarization with a decrease in input resistance much smaller than that accompanying a GABA potential of similar amplitude. The action potential amplitude was reduced by L-glutamate application. The reversal potential could not be determined accurately but appeared to be near zero membrane potential.4. Glutamate application produced, in addition, a burst of inhibitory synaptic potentials in the cell, presumably by depolarizing either inhibitory presynaptic nerve terminals or nearby inhibitory cell bodies.5. Acetylcholine (ACh) produced no detectable change in membrane resistance or potential.6. Application of the three drugs to first-order sensory cells in the spinal cord had no effect on their membrane properties.


The total thermal insulation of the new-born baby. 1. One hundred and seventeen healthy new-born babies weighing between 0.9 and 4.8 kg at delivery have been studied during the first ten days of life, and sixteen of these babies have been studied serially for 6 weeks after birth. The babies lay supine in a draught-free environment (air speed 4-5 cm/sec) of moderate humidity. The operative temperature was between 26 and 38 degrees C for the babies who were studied naked.2. Total non-evaporative heat loss was calculated from simultaneous measurements of oxygen consumption, evaporative water loss and the concomitant change in mean body temperature.3. Approximately 10% of the total body surface area was in contact with the mattress or floor. Conductive heat loss accounted for only about 5% of all non-evaporative heat loss when the naked baby was lying on a thick foam mattress, but for as much as 25% when the baby was lying in a water-jacketed chamber with a floor of clear plastic approximately 5 mm thick.4. Insulation to heat loss by convection and radiation varied with environmental temperature. Total specific insulation was low in a warm environment when the naked baby vasodilated, and rose by between 16 and 25% to a maximum in an environment of 31 degrees C. It decreased significantly when the baby became physically active in environments with a temperature less than this.5. Total specific insulation in an environment of 31 degrees C varied with body size: it averaged 0.156 degrees C.m(2).hr/kcal in seven naked babies weighing 0.9-1.2 kg, rose to 0.190 degrees C.m(2).hr/kcal in twelve babies weighing 1.8-2.2 kg, and averaged 0.201 degrees C.m(2).hr/kcal in the thirty-four babies who weighed over 3 kg. Tissue insulation accounted for 23% of this total specific insulation in the smaller babies, and about 28% of the total in babies weighing over 3 kg.6. Clothing ten babies in a vest, napkin and long cotton nightdress increased the total specific insulation by an average of 0.23 degrees C.m(2).hr/kcal.


Guides: starting on your own.

Guides: starting on your own.


Goals: The new dentist's responsibility to society and his community.


Ground rules: how to build a successful practice.


Academic reinforcement in dentistry at Howard University.


The recovery of resting potential and input resistance in sheep heart injured by knife or laser. 1. A lesion 100 mu in diameter with well-defined boundaries was made with a laser in Purkinje fibres from sheep hearts. The membrane potential and the input resistance recorded in the intact tissue at about 0.5 mm from the edge of the lesion were found to drop at the instant of injury. The corresponding decrease of input resistance fits quantitatively the transmission line theory applied to a cable terminated by a short circuit at the lesion.2. The input resistance and the membrane potential were found to rise simultaneously during healing-over. The membrane potential returned to its original level within 1 min. By then, the input resistance had settled either to the same value as before injury, or to a higher value matching quantitatively the theoretical resistance of a cable terminated by an infinite resistance at the lesion.3. Neither membrane potential nor input resistance recovered in calcium-free solutions. But healing-over rapidly occurred when calcium was added to solutions that might otherwise differ widely in composition.4. The transmission line model fits all observations if it is assumed that the injury causes a leak or short circuit in the ;cable' that is soon closed, or rendered open circuit, by the development of a new diffusion barrier in the presence of calcium ions.


Acetylcholine in adrenergic terminals of the cat iris. 1. Acetylcholine was bio-assayed in the normal cat iris, and also after selective sympathetic or parasympathetic denervation. Sympathetic denervation caused no significant change in the acetylcholine content of the cat iris, whereas selective parasympathetic denervation reduced the acetylcholine content below the level of detectability, which on the average was at about 5% of the acetylcholine content of the normal iris.2. It is concluded that if adrenergic terminals contain any acetylcholine, it is less than what is detectable with the methods available at present, and most certainly less than 6% of the acetylcholine content of cholinergic neurones.3. On the basis of these and other recently obtained observations, the hypothesis of Burn & Rand (1965) of a cholinergic link in the adrenergic transmission is discussed. It is proposed that it is more reasonable to suppose an interaction between peripheral adrenergic and cholinergic terminals than to presume a cholinergic mechanism within adrenergic nerve fibres.


Shortage of dentists? Look to "womanpower.


Modern offices. "Now we can practice dentistry of the '70s".


Death.

Death.


Teaching after graduation.

Teaching after graduation.


The use of operant techniques for modifying the behavior of the severely and profoundly retarded. I. Introduction and initialpphase.


G. V. Black. How to rest, or modes of recreation.


Salmonella--its presence in and removal from a wastewater system.


Sites of action of RAM-302 and nalorphine as morphine antagonists.


Electrographic effects of diacetylmorphine (heroin) and naloxone in man.


Electrical treatment--a balanced view.

Electrical treatment--a balanced view.


Embryology made easy. 3. The developing embryo.


The forgotten patient.

The forgotten patient.


Ménière's disease.

Ménière's disease.


'A heart of stone'.

'A heart of stone'.


How to wear three hats at once and work a 36-hour day.


Lower extremity bracing in paraplegics with usage follow-up.


Our experiences about pregnancy and delivery of the paraplegic woman.


A study on sexual function in 56 male patients with complete irreversible lesions of the spinal cord and cauda equina.


Postural variations of the capacity in tetraplegics.


Bed sores treated with negative air-ions.


Renal sodium and water conservation in acute paraplegia.


The dilatation of the upper urinary tract in paraplegics.


The salvage of kidney function.

The salvage of kidney function.


Cultural deprivation. A clinical dimension of education.


Binding of (3H)- phenylalanyl-t-RNA to nucleoprotein particles derived from rat liver polysomes via T1-ribonuclease treatment.


Some variables contributing to the onset of cigarette smoking among junior high school students.


Some aspects of calcium metabolism in normal and osteoporotic Bantu subjects with special reference to the effects of iron overload and ascorbic acid depletion.


Dermatoglyphic analysis in a highly mutilating syndrome.


Blood selenium in naturally fed horses and the effect of selenium administration.


The metabolism of niridazole (AMBILHARR) in man. II. Investigations on patients suffering from clinically advanced forms of Schistosoma mansoni infection.


Effect of muscular dystrophy on the rate of RNA synthesis in chickens.


Glycerophosphatide biogenesis. I. Subcellular localization of cytidine triphosphate: phosphatidic acid cytidyl transferase.


Dissociation and preferential hydration of oxyhaemoglobin in concentrated CsC1 solutions.


Physicochemical studies on bovine cardiac globular actin.


Phosphate esters in human erythrocytes. VII. Further evidence for ribose 1,5-diphosphate as a natural metabolite.


Synthesis of chicken liver pyruvate holocarboxylase in vivo and in virro.


Decrease of the hepatic ATP content and gluconeogenesis in ethionine-treated rats.


Studies on the influence of thiamine on the synthesis of thiamine pyrophosphate-dependent enzymes in Saccharomyces cerevisiae.


Regulation of O-alkylhomoserine-forming enzyme involved in methionine biosynthesis in Corynebacterium acetophilum.


Free lysine compartments in rat liver cells.


The influence of magnesium on calcium release from bone in vitro.


Polyphosphate formation by caries-conducive streptococcus SL-I.


Cell wall arabinogalactan of Mycobacterium phlei.


Altitude hypoxia and erythrocyte phosphates.


Sources of urea in Neurospora.

Sources of urea in Neurospora.


The 220 MHz and 60 MHz H NMR spectra of 5'-deoxyadenosylcobalamin and cobinamide coenzymes.


Biosynthesis of colistin by a cell-free system Bacillus colistinus Koyama.


Microsomal structural protein after x-irradiation.


Cardiopulmonary resuscitation: a review of 184 cases and some applications for future improvements.


A case of surgical emphysema occurring spontaneously in labour.


The student health services: University of Rhodesia.


Functions of visual imagery in the learning and concept formation of children.


Self-description as a function of evaluative and activity ratings among American and Indian adolescents.


Phosphorylcholine: a tumour-inhibitory substance extracted from seminal plasma.


Hematology of prosimian primates. II. A comparative study of lemuriformes in captivity in Madagascar and North Carolina.


Effect of copper and cobalt supplementation on the digestibilities of the nutrients and their retentions by cattle.


Investigation concerning the mode of termination of the olivocerebellar system.


Relation of number of embryos in domestic sows to sex steroid hormone changes during the first 28 days of pregnancy.


Serum enzyme and electrolyte levels of "stress-resistant" Chester White pigs and "stress-susceptible" Poland China pigs.


Leprosy in Hawaii.

Leprosy in Hawaii.


Mycetoma--a histological study.

Mycetoma--a histological study.


Excretion of 14C in urine of the domestic sow after injection of radioactive estradiol-17 beta, esterone, corticosterone and cortisol.


Celiac axis syndrome.

Celiac axis syndrome.


Silent rupture of the uterus.

Silent rupture of the uterus.


Conditions simulating acute appendicitis.


Automation in medicine.

Automation in medicine.


Studies on ADP-induced platelet aggregation in normal and diseased groups.


Anticoagulant therapy in cerebrovascular disorders.


Pesticides.

Pesticides.


Leiomyosarcoma of the uterus. Current case reports. Review of all cases in Honolulu, 1955-1965. Review of the literature.


The "Y Y" syndrome.

The "Y Y" syndrome.


Open lung biopsy in obscure lung conditions.


Studies on platelet adhesiveness in diabetes mellitus and atherosclerotic heart disease after glucose load.


Penicillin encephalopathy in children.

Penicillin encephalopathy in children.


A study on fasting true sugar level in venous blood in 510 normal individuals.


Blood platelets and thrombosis.

Blood platelets and thrombosis.


Myasthenia gravis.

Myasthenia gravis.


Haematological aspects of Indian kalaazar.


Urinary tract infection in children.

Urinary tract infection in children.


Enteric perforation. A study of 60 cases.


Suprascrotal vasectomy.

Suprascrotal vasectomy.


Successful resuscitation following cardiac arrest.


The blood in kala-azar.

The blood in kala-azar.


Spinal extradural cyst.

Spinal extradural cyst.


Bio-engineering in relation to spinal mechanism.


The coelomic elements of sea urchins (Strongylocentrotus). V. Ultrastructure of leukocytes exposed to bacteria.


New host and distribution records of Acarina (Myobiidae, Sarcoptidae, Teinocoptidae) from India.


Factors influencing the distortion of sex ratio in Aedes aegypti.


Comments on patients with sex chromosome aneuploidy: dermatoglyphs, parental ages, Xg a blood group.


The effect of food deprivation on enzyme activity in developing brain.


On-line display of inhibitory post-synaptic potentials and conductance changes from cortical neurones.


A comparison of the effects of close shearing and of injections of noradrenaline into a lateral cerebral ventricle in the Welsh Mountain sheep.


Segmental integration of converging inputs to thoracic respiratory motoneurones.


Studies on fat absorption in sheep with chronic fistulation of the thoracic duct.


Unilateral renal excretory responses to close arterial infusions of potassium chloride in conscious sheep.


Dopamine in the blood of the ruminant.

Dopamine in the blood of the ruminant.


Further evidence for right atrial receptors affecting heart rate.


An estimate of calcium concentration changes during the contraction of single muscle fibres.


Calcium influxes in perfused squid giant axons during voltage clamp.


Membrane potential of perfused and isolated rat liver.


An increase in potassium efflux in human red cells associated with reversing the sign of the membrane potential.


The inhibitory effect of potassium ions on insulin-stimulated sugar transport in rat soleus muscles.


Mineralocorticoid action on human and cat-pad eccrine sweat glands.


Effect of muscle activity on denervation hypersensitivity.


Cortisol turnover in the sheep foetus immediately prior to parturition.


Excitability of human motoneurones during effort.


The relationship between the external calcium concentration and the contracture tension developed by auricular trabeculae isolated from the heart of the frog, Rana pipiens.


Eenergy balance during working contractions of frog muscle.


The passage of amino acids into the rat's brain.


Electrical connexions between cells at neural stages of the axolotl.


Receptive properties of centrifugal cells projecting to the pigeon retina.


Formation of isorhodopsin in isolated frog retinae by intense nanosecond flashes.


Retinal disparity and retinal dominance of binocular cortical neurones.


Body temperature in exercise.

Body temperature in exercise.


Interaction between peripheral temperature receptors and central neurones responding to brain temperature.


Release of 5-hydroxytryptamine (5-HT) from septum and caudate nucleus.


The effect of acute hypocapnia on maternal placental blood flow in rabbits.


Spinal cord and root potentials.

Spinal cord and root potentials.


Excitation of identified supraoptic neurones by the iontophoretic application of acetylcholine.


The effect of topically applied amino acids on primary afferent terminal excitability in the rat cuneate nucleus.


Antidromic invasion of cerebellar Purkynĕ cells.


Some effects of posterior pituitary extracts on nucleoli of supraoptic nerve cells.


Movements of the jaw resulting from the application of external forces.


The influence of chronic administration of pentagastrin on the rat pancreas.


Uptake of 3H-gamma-aminobutyric acid (GABA) by rat retina.


Arterial blood pressure regulation (film).


Variations in deep body temperature in the young unrestrained pig over the 24 hour period. 1. The temperature near the carotid artery has been measured in the unrestrained pig by means of radiotelemetry. When the animals were housed singly under constant conditions of temperature and lighting the temperature rhythm appeared to be related only to the time of feeding. A similar record was obtained from temperature measurements made in the hypothalamus.2. Over the range of ambient temperatures 10-30 degrees C the mean body temperature was 38.8 degrees C. No consistent variation occurred with ambient temperature, but on initial transfer from 10 to 30 degrees C ambient temperature the body temperature decreased, while on initial transfer from 30 to 10 degrees C it increased.3. When one pig was housed in a hut with a small outside yard a nychthemeral rhythm was sometimes superimposed on that imposed by feeding. When two pigs were kept in a paddock containing a hut the nychthemeral rhythm was more pronounced.4. It is concluded that in the pig there is very little innate circadian temperature rhythm and that the temperature variations seen are related chiefly to feeding and activity.


The penetration of inulin, sucrose, mannitol and tritiated water from the interstitial space in muscle into the vascular system. 1. An isolated gastrocnemius muscle from cat was perfused with a modified Ringer fluid containing the extracellular tracers mannitol, sucrose and inulin and in some cases tritiated water (HTO). When equilibration of the tracers between the perfusate and the tissue was obtained, perfusion with tracer-free fluid was started.2. The fractional rate of escape, Phi (t), of the tracers was followed. For all tracers it declined steadily with time. The rate of decline was faster for the smaller extracellular molecules when any combination of two extracellular tracers was studied.3. Arrest of flow for 1-2 min lead to an increase in Phi (t) for the extracellular tracers when flow was resumed. There was little or no effect upon Phi (t) for HTO.4. Doubling the rate of flow had no effect upon Phi (t) for the extracellular tracers, while that of HTO increased.5. We conclude that the cause of the decline in Phi (t) for the extracellular tracers is concentration gradients in the interstitial space. The findings raise problems in methods for studying capillary permeability by means of the fractional rate of escape of tracers from the interstitial space into the vascular system.


The influence of commitment and self-esteem on susceptibility to persuasion.


Aptitude, dogmatism, and college press as codeterminants of academic achievement.


Lymphocytopenia with lymph extravasation from abnormal lymphatics: its occurrence with chylous ascites and chylothorax.


A simplified method for cannulation of the normal canine cervical thoracic duct.


The superficial lymphatic system of the cat.


Fundamentals of publicity applied to medical exhibits.


Immunosuppressive drugs and lymphatic depletion by thoracic duct fistula in adult progressive glomerulonephritis.


The pharmacologic basis for the choice of an analgesic. II. Mild analgesics.


Hosts and distribution records of Mexican smut fungi.


Crossing of mortality curves.

Crossing of mortality curves.


Sterols of Oocystis polymorpha, a green alga.


Sustained release hormonal preparations. 12. Plasma levels of 6-methyl-17-alpha-acetozy-4,6-pregnadiene-3,20-dione in hamsters.


A new marine sterol, 22-trans-24-norcholesta-5, 22-dien-3-beta-ol.


Identification of cholesterol, 7-oxocholesterol, pregnenolone, progesterone, 20-hydroxypregn-4-en-3-one epimers and 5-beta-nndrostane-3,17-dione in plasma and ovarian tissue of the domestic fowl.


Conversion of an equilenane to the estrane: synthesis of d1-3-methoxy-17 beta-carboxy-1,3,5(10)-estratriene(1).


Pharmacologic and toxicologic studies with the monopotassium salt of acetylenedicarboxylic acid.


Rhizosphere mycoflora of some bryophytes.


The influence of climate and atmospheric pollution on exacerbations of chronic bronchitis.


Interaction of nitrogen dioxide with cholesterol-lecithin mixed monolayers.


Distribution of sulfur dioxide over metropolitan St. Louis, as described by empirical eigenvectors, and its relation to meteorological parameters.


A numerical experiment in simulating the transport of sulfur dioxide through the atmosphere.


Concentration of effluents in a plume as predicted by a model and observed in the field.


An efficient absorbing reagent for nitrogen dioxide.


Determination of chrysotile in airborne asbestos by an infra-red spectrometric technique.


Cancers of the lung and nasal sinuses in nickel workers. Men employed in a nickel refinery in South Wales were investigated to determine whether the specific risks of developing carcinoma of the bronchi and nasal sinuses, which had been associated with the refining of nickel, are still present. The data obtained were also used to compare the effect of age at exposure on susceptibility to cancer induction and to determine the rate of change of mortality after exposure to a carcinogenic agent had ceased.Eight hundred and forty five men were studied who had been employed in the industry for at least 5 years and whose first employment was in or before April 1994. All but 27 (3.2 per cent) were traced until death or January 1, 1967.Altogether 482 of the men had died: 113 from lung cancer and 39 from nasal cancer. In men employed before 1925, deaths from lung cancer varied from about 5 to 10 times the numbers that would have been expected from the corresponding national mortality rates, while the deaths from nasal cancer varied from about 100 to 900 times the expected numbers. Among men first employed in 1925 or after there were 8 deaths from lung cancer against 6.2 expected and no deaths from nasal cancer. The death rate from causes other than cancer was similar to that experienced by men in the same geographical area irrespective of their date of first employment.Susceptibility to the induction of nasal cancer increased with age at first exposure, but susceptibility to the induction of lung cancer varied irregularly. The trends in susceptibility showed some similarity to the trends in the national mortality among men employed at similar ages. It is suggested that susceptibility to cancer induction is determined by the amount of previous exposure to other agents.The risk of developing nasal cancer persisted with little change 15 to 42 years after the carcinogen was eliminated whereas the risk of developing lung cancer decreased. If the effects of cigarette smoking and the specific occupational hazard interact, the reduction in the risk of lung cancer could be due to the differential elimination of heavy cigarette smokers.


Pattern of malignancy in a place in Western India. Analysis of 4500 cases of malignancy encountered in a general hospital in Western India showed that: (1) parts of buccopharynx were the site involved in nearly 25 per cent of these cases. In women the incidence of buccopharyngeal carcinoma was less than in men but was not insignificant (nearly 5 per cent of all malignancies found in women); (2) the cervix was the next frequent site involved accounting for 22 per cent of the total and 80 per cent of the female cancer; (3) cancer of breast was not less common (5 per cent of the total and 12 per cent of the female cancer); (4) oesophageal cancer was far more common than malignant neoplastic lesions of the other parts of the gastrointestinal tract (two-thirds of all cases being found in the oesophagus); (5) carcinoma of skin was not a common lesion.High frequency of the types of cancer mentioned in the first two paragraphs is a "ommon facto" of many such reports from India. On the other hand, reported incidences of the types mentioned in the paragraphs number (3), (4) and (5) show wide variations in different parts of the country.


An analysis of clinical and histopathological features in 101 cases of carcinoma of breast in women under 35 years of age. An analysis of 101 cases of breast carcinoma occurring in patients under 35 years of age is presented with details of clinical stage, site, size and histological appearances of the tumour. Various factors are correlated with survival and the prognosis of the patient under 35 years is found to be closely related to the histological appearances of the tumour, which are reflected in the clinical stage at presentation. The question of treatment of carcinoma of the breast in the young woman is discussed.


The use of discriminant analysis for examining the histological feathers of oral keratoses and lichen planus. In a retrospective survey of 235 cases in which the diagnosis on biopsy was lichen planus, keratosis or leukoplakia, the histological features were re-assessed as objectively as possible and without reference to the original diagnosis.The tissue changes were recorded under 39 headings, and many were assessed on a roughly quantitative basis. In addition, two clinical features were included; whether the biopsy was from the buccal mucosa (as opposed to some other intraoral site) and whether the lesions involved multiple intraoral sites. For each possible pair of diagnostic categories (keratosis and leukoplakia, lichen planus and keratosis, lichen planus and leukoplakia) the recorded findings were subjected to discriminant analysis in order to provide a quantitative assessment of the value of each individual feature for discriminating between the two diagnostic groups. The computer programme also provided for the application of these calculated values to yield a "score" for each case, and for an assessment of the significance of the separation of the diagnostic groups thus achieved. In general, the values calculated by the computer for the discriminatory value of each tissue change accorded with our subjective impressions, but a number of features that were given a relatively high value had not previously been recognized as important in differential diagnosisA discriminant analysis was also performed on those cases of leukoplakia known to have later developed a carcinoma, in comparison with the leukoplakia cases that did not develop carcinoma. High values were accorded mainly to the well-known features of epithelial atypia, but a similar high value was indicated for the presence of Russell bodies. we had not previously realized that the presence of Russell bodies was of prognostic significance in this context.When the total scores for the groups of cases were analysed, it was found that the separation of each pair of diagnostic groups was significant at the 1% level. The separation of leukoplakia cases that subsequently developed carcinoma, from those that did not develop carcinoma, was significant at the 5% level. In this latter analysis, a better separation might be achieved with larger numbers of cases, but there will always be the complicating factor that an unknown number of leukoplakia cases would develop carcinoma if the patient had received no treatment.


The use of discriminant analysis for examining the histological features of oral keratoses and lichen planus. Appendix on discriminant analysis.


Liposarcoma. A review of 60 cases.

Liposarcoma. A review of 60 cases. Sixty cases of liposarcoma are presented. The pathological appearances, clinical features and methods of treatment are described. The overall 5-year survival was 64%.


Radiation-induced fibrosarcoma.

Radiation-induced fibrosarcoma. Six cases of fibrosarcoma arising in previously irradiated tissues are reported, out of a total of 220 cases of fibrosarcoma treated at Mount Vernon Hospital during the last 23 years.This rare occurrence may follow at any interval from 3 to 38 years after irradiation, usually after high dosage. Four of our six cases are known to have died of the disease.The literature regarding radiation-induced fibrosarcoma is reviewed and it is suggested that adequate excision or amputation may be curative, if undertaken early enough.


Diffusible factors from malignant cells which affect epidermal survival and differentiation. Embryonic chick epidermis, if cultured for 4 days on a TH millipore filter overlying certain malignant dermal fibroblasts, shows abnormalities ranging from complete degeneration to hypertrophy and abnormal differentiation. The effect of the tumour cells is prevented if the thickness of the filter is doubled, to 50 μm., but not if a 25 μm.-thick membrane is coated with a thin collagen gel. When a semipermeable membrane is interposed between the cells and the epidermis, the latter does not degenerate, but keratinizes without showing the usual stages of differentiation.The malignant cells sometimes cause hypertrophy of the epidermis when cultured beneath the dermis of intact skin, but have no effect when grown on the peridermal surface of this tissue or of isolated epidermis.Freeze- or heat-killed dermal cells, whether normal or malignant, provide an unsuitable substratum for epidermal survival, possibly due to adsorption of intracellular constituents on to their surfaces.IT IS SUGGESTED THAT THE MALIGNANT FIBROBLASTS EXAMINED PRODUCE AT LEAST TWO SUBSTANCES HAVING AN EFFECT ON EPIDERMIS: one of small molecular size affecting differentiation, and a toxic macromolecule. A growth-promoting substance may also be produced by the cells of one subline.


Adrenocortical activity in disseminated malignant disease in relation to prognosis. Adrenocortical activity has been assessed in patients with inoperable carcinoma of the bronchus or with disseminated malignant disease of other organs. The mean basal plasma cortisol level was higher in the former than in the latter and both were higher than the controls. Each had abnormally high midnight levels, particularly those with oat cell carcinoma of the bronchus. After the administration of a single dose of dexamethasone both groups suppressed poorly compared with the controls. Failure to suppress was associated with a poor prognosis.


Preliminary observations on the histochemistry of the cell surface of carcinoma of the cervix. Histochemical studies on the cell surface and intercellular matrix of normal cervical epithelium, and squamous cell carcinomata have shown the mucosubstances present may be symbolized by the descriptive formula:C(G) mucosubstance; B 3.5; A 2.5 (0.6m MgCl(2)); T; S.This indicates that sulphate groups are absent and that the intercellular matrix and cell coat are rich in hyaluronic and sialic acids or closely related compounds. These may be important in masking the antigenic expression of the tumour cells.We have not been able to detect any alteration in the mucosubstances at 7 days following radium treatment.


A human tissue culture cell line from a transitional cell tumour of the urinary bladder: growth, chromosone pattern and ultrastructure. Cell cultures were made from 18 human bladder tumours. Three cell lines were maintained for seven transfer generations, but all had a "fibroblastic" morphology and a normal diploid karyotype. A fourth line has been maintained for over 80 transfer generations. This was derived from a well differentiated papillary tumour of bladder. Morphologically the light and electron microscopic structure of the cells resembled that of bladder tumours. The cells formed tumour nodules, with a similar structure, when transplanted into hamster cheek pouches. There is a stem line chromosome number of 48. Karyotypes of 60% of the stem line cells had one extra chromosome in Group C and one in Group D.


The effect of thyroactive substances on the induction of cervico-vaginal and vulval tumours in castrate rats at various levels of carcinogenic treatment. Medication with L-thyroxine or methylthiouracil of castrate rats painted weekly 5, 10, 20 or 40 times with DMBA does not alter the order of thresholds for carcinogenesis which increases from that for cervico-vaginal epitheliomas via squamous celled and basal celled vulval tumours to cervicovaginal sarcomas. Methylthiouracil lowers the threshold for basal celled vulval neoplasms.Sarcomas reach a peak of 25% with 20 doses of DMBA in non-medicated rats, but rise to 90% and at a faster rate in animals given either of the thyroactive drugs with further carcinogenic treatment.The optimal dose phenomenon for cervico-vaginal epitheliomas, i.e. a significant fall with continued painting from a peak reached by 5 to 20 doses of DMBA, is not affected by medication with methylthiouracil or L-thyroxine.Thyroactive compounds accelerate the formation of squamous celled vulval tumours which reach a maximum with 20 DMBA paintings; the total incidence as well as the proportion of carcinomas to papillomas falls with further treatment.Methylthiouracil promotes formation of basal celled vulval tumours at low dose levels, but inhibits it at the highest. In medicated as in non-medicated rats the induction of basal celled tumours of the vulva follows an optimum dose pattern.The optimal dose phenomenon and the effect of thyroactive compounds on the tissue-specific sensitivity to carcinogens are discussed.


Pulmonary adenomata induced by carcinogen treatment in organ culture. Influence of increasing amounts of carcinogen. Explants of lung from 1 month old inbred BALB/c mice were cultured in vitro for 4 days with 3-methylcholanthrene added to the culture medium at various dose levels. They were subsequently implanted subcutaneously into 6-week-old mice of the same strain.Lung adenomata appeared in a high proportion of explants.


The mechanism of carcinogenesis by the neutral fraction of cigarette smoke condensate. Sixteen groups, each of 50 Swiss female SPF mice, were treated thrice weekly with various combinations of 3,4-benzopyrene (BP) and/or the neutral fraction of cigarette smoke (NF) in acetone applied to the skin. Some groups received one carcinogen, some the other and some a mixture of the two. Skin tumour incidence rates were found to increase both with the dose of NF and with the dose of BP. With BP alone a threshold dose was found beyond which a very heavy incidence rate of malignant skin tumours occurred. After correction of the results for intercurrent deaths it was found that when NF and BP are applied together as a mixture they do not act independently in the production of malignant skin tumours but interact positively. This suggests that some of the components of NF act as cocarcinogens rather than as complete carcinogens. Treatment with NF appeared to increase the incidence of malignant lymphomas. The data were not suitable for deciding whether the various treatments influenced the rates of incidence of internal tumours of other types, for example, lung tumours.


The effects of x-irradiation and anti-lymphocyte serum on the responses to tumour allografts. The growth of a CBA mammary adenocarcinoma has been studied following transplantation to syngeneic and allogeneic recipients, with particular reference to the susceptibilities of the primary and secondary responses elicited by the tumour allografts, to impairment by whole-body X-irradiation and by treatment with rabbit-anti-mouse lymphocyte serum. In syngeneic recipients, the diameter of tumour implants increases linearly with time and there is no difference in the growth curves in females and in males. Later tumour generations grow faster than earlier generations. In allogeneic recipients, there is a relationship between the tumour diameter on day 21 (T) and the dose of X-irradiation (D) administered before implantation:T = 0.028 D - 9.17for early tumour generations (SMT4) but this is obscured for later generations (SMT21). The primary response to tumour allografts was radiosensitive whereas the secondary response was radioresistant. This radioresistance of the secondary response persisted for at least 5 months after primary sensitization. Unlike whole-body X-irradiation, treatment with rabbit-anti-mouse lymphocyte serum suppresses both the primary and secondary responses to tumour allografts. The possibility is considered that after exposure to antigenic stimulation, an immunologically reactive cell population is formed which is radioresistant but sensitive to ALS, unlike the precursor cells from which this population is derived, which are radiosensitive and sensitive to ALS.


Studies of the rat immune response to plasmacytoma 5563 in C3H mice. Washed lymphocytes from immunized rats showed no reaction against mouse plasmacytoma 5563 in vivo or in vitro.Cell-free lymph from immunized rats was shown to be cytotoxic to the tumour cells in vitro. This effect we have shown to be solely in the 19s fraction after Sephadex G-200 separation.This 19s fraction conferred partial protection to tumour bearing mice when given shortly after transplantation, but had negligible effect against late well established tumour.


The effect of the age of mice on the incidence of skin cancer. The plausibilities of two hypotheses explaining the increased cancer incidence rate in old age caused by a constant dose of carcinogen were compared using a mouse skin painting experiment in which two groups of mice started treatment at different ages. It was shown that the hypothesis of the increased rate being caused simply by increased vulnerability of old animals was not as plausible as the alternative hypothesis of the carcinogen acting to some extent cumulatively.


Nuclear proteins and their metabolism in hormone responsive and unresponsive BR6 mouse mammary tumours. The histone, neutral and acidic nuclear-protein content of BR6 mouse mammary tumours have been measured and related to growth rate and hormone responsiveness. In unresponsive tumours, histone and neutral nuclear-protein content was inversely correlated with growth rate while acidic nuclear-proteins were directly correlated with growth rate. The histone content of these tumours was low when compared to pregnancy dependent tumours growing at the same rate under the same physiological conditions.In vitro incorporation of labelled amino acids into total protein and the nuclear proteins was also measured. Pregnancy independent tumours had higher rates of total protein synthesis than pregnancy dependent tumours The rates of incorporation of amino acids into the nuclear proteins also tended to be higher in independent tumours.


Amino acid contribution to hapten specificity in delayed reaction to arsanilic acid conjugates.


Independent and consecutive action of C5, C6 and C7 in immune hemolysis. II. Formation and decay of the intermediate complexes EAC1-5 and EAC1-6.


Independent and consecutive action of the complement components C5, C6 and C7 in immune hemolysis. I. Preparation of EAC1-5 with purified guinea pig C3 and C5.


A simple method for quantitation of hemolytic antibodies.


The psychoanalytic vision of reality.

The psychoanalytic vision of reality.


On the concept of reality testing.

On the concept of reality testing.


Some psychoanalytic considerations on moods.


Catcher gone awry.

Catcher gone awry.


A psychoanalytic study of the desire for sexual transformation ('transsexualism'): the plaster-of-paris man.


Fetishism: a case report.

Fetishism: a case report.


Learning from psychoanalytic supervision.


On individual supervision.

On individual supervision.


The problems of supervision in psychoanalytic education.


Technical remarks on the supervision of psychoanalytic treatment.


The psychopathology of the psychoses: a reply to Arlow and Brenner.


In vivo formation of tyrosine from phenylalanine in brain.


Blood flow in adipose tissue and skeletal muscle during hemorrhagic shock in heparinized dogs.


Functional relationships of brin cicuits in control of drinking behavior.


Further studies on homocarnosine induced hypothermia.


The pharmacological specificity of muscarinic receptors in the posterior hypothalamus of the rat.


Vitamin B12 dependency and cobalt-dependent metabolism.


Vitamin B12-dependent methylmalonicaciduria: amino acid toxicity, long chain ketonuria, and protective effect of vitamin B12.


The urinary excretion of aminoimidazolecarboxamide in the Lesch-Nyhan syndrome.


Excretion of catecholamine metabolites by children with familial dysautonomia.


Corticosteroids in the treatment of Engelmann's disease: progressive diaphyseal dysplasia.


Benign persistent asymptomatic proteinuria in childhood.


The benign effects on rabbits' lungs of the aspiration of water compared with 5 per cent glucose or milk.


Evaluation of a school for young mothers. The frequency of prematurity among infants born to mothers under 17 years of age, according to the mother's attendance of a special school during pregnancy.


Generalized lymphangioma in infancy with chylothorax.


Children of divorce.

Children of divorce.


Some comparative costs in comprehensive versus fragmented pediatric care.


Behavioral reactions to minor illness in preschool children.


Congenital deficiency of factor 13: report of a family from Newfoundland with associated mild deficiency of factor XII.


The critically ill child: acute metabolic disease in infancy and early childhood.


Familial congenital duodenal atresia.

Familial congenital duodenal atresia.


American Academy of Pediatrics Committee on Environmental Hazards. Pediatric aspects of air pollution.


Committee on drugs. Should steroids be used in treating bronchiolitis?


Intra-uterine transfusion.

Intra-uterine transfusion.


Brazilian contribution to phototherapy.

Brazilian contribution to phototherapy.


Possible hazards of handling antineoplastic drugs.


Urinary retention, fecal impaction, and neurogenic disease of the colon.


"Diaper dermatitis" from allergens excreted in urine.


Diabetes mellitus and congenital rubella.


Physical abuse of children.

Physical abuse of children.


Special auditory tests in diagnosis of vertigo.


Mechanical changes of the ossicular chain due to head injury.


Nasopharyngometry.

Nasopharyngometry.


Nassau County microwave oven study, June 1969--March 1970.


Radioactive cesium in estuaries.

Radioactive cesium in estuaries.


Krypton-85 levels in the environment determined from dated krypton gas samples.


Some fine structural changes in sympathetic neurons following axon section.


Reconstruction of the elastic cartilage by isolated chondrocytes in autogeneic transplants.


Differential induction of cytoplasmic guanine deaminase isozymes under guanine stress in rat liver and brain.


Biosynthesis of the 4,5-dimethyl-1,2-phenylene moiety of vitamin B12.


The isolation and characterization of N-[9-(beta-D-ribofuranosyl)-purin-6-ylcarbamoyl]glycine from yeast transfer RNA.


N-formylmethionine: the N terminus of Clostridium pasteurianum rubreodoxin.


Involvement of p-OH-benzoyl-coenzyme A in the biosynthesis of ubiquinone-9 in the rat.


Differential inhibition of 28S-18S RNA and 5S RNA synthesis in the cycloheximide-treated Xenopus laevis embryonic cells.


Observations on yeast pyruvate kinase activity in vivo.


Effect of enzyme concentration on the kinetics of D-lactate dehydrogenase from Aerobacter aerogenes.


Cardiolipin from beef heart mitochondria: fatty acid positioning an molecular species distribution.


Maintenance of protein synthesis in hearts of diabetic animals.


Studies on the regulation of ribulose-1,5-diphosphate carboxylase synthesis during the cell cycle ofthe eucaryote chlorella.


Mechanism for cadmium and zinc antagonism of copper metabolism.


The N-formyl-L-tryptophan-chymotrypsin complex in solution.


Potassium-39 nuclear magnetic resonance.


Detection of a phosphorylated intermediate in mitochondrial oxidative phosphorylation.


DNA-dependent RNA polymerase from mitochondria of a cytoplasmic "petite" mutant of yeast.


Identification of 2-amino-4-hydroxy-6-methylpteridine as a naturally-occurring compound in two methane-oxidizing bacteria.


Factors and rifampicin influencing RNA polymerase isolated from chromatin of eukaryotic cell.


Wavelength dependence of electron flow and oxygen evolution in isolated chloroplasts: a possible role for carotenoids.


Proton NMR studies of hemoglobin in H2O.


Regulation by estrogen of organ-specific synthesis of a nuclear acidic protein.


Brucella melitensis infection in female kids born into a heavily infected environment.


Serum adenosine deaminase activity in normal cattle.


Observations on serum adenosine deaminase activity in experimentally produced liver diseases of cattle and sheep: yellow-wood, lantana, carbon tetrachloride and chronic copper poisoning.


Observations on the histology of the lung of Gallus domesticus.


An attempt to explain the caused of cluttering with the LLMM theory.


Investigations on incidence and symptomatology of cluttering.


Observations on tachylalia.

Observations on tachylalia.


A casuistic model of a logopedic assessment in private practice.


Cluttering and its problems.

Cluttering and its problems.


Some problems of cluttering.

Some problems of cluttering.


Stuttering and cluttering. Developmental aspects of dysrhythmic speech.


Vrious aspects of cluttering.

Vrious aspects of cluttering.


A contribution to pharmacotherapy of stuttering and cluttering.


Relations between motorics of speech and general motor ability in clutterers.


Tachyphemia. A clinical contribution.

Tachyphemia. A clinical contribution.


Haematological problems in a geriatric unit with special reference to anaemia.


Evaluation of the d-Xylose absorption test in elderly in-patients.


The continued apposition of physiological dentine in the mature tooth.


The transitional object and the fetish with special reference to the role of illusion.


On the analyst's silence in psychoanalysis: a synthesis of intrapsychic content and interpersonal manifestations.


A superego distortion: the defensive use of expressions of moral concern.


A function of action in the early development of identity.


Comments on the screening function of a 'technical affect', with reference to depression and jealousy.


What he is or what he does.

What he is or what he does.


Psychoanalytic reflections on the psychiatry of the poor.


The inhibitory effect of tetracycline on osteogenesis in organ culture.


The development of rabbit eggs after culture in vitro for 1-4 days.


The effect of trypan blue on the growth of the rat embryo in vivo.


Characteristics of five cell types appearing during in vitro culture of embryonic material from Drosophila melanogaster.


On the occurrence of specific adhesion between cells.


Centrifugal dorsal root discharges induced by motoneurone activation. 1. It has been confirmed that antidromic stimulation of motoneurones in the cat lumbar cord can induce, when properly conditioned, a centrifugal discharge in dorsal root afferent fibres.2. The effective conditioning can be (a) an orthodromic volley to the same or an adjacent dorsal root, (b) a volley to the dorsal column one or two segments above the tested level, or (c) a natural stimulus applied to the ipsi- or contralateral hind limb.3. The conditioning stimulus acts by increasing presynaptic excitability; the peak of its effect (maximum presynaptic depolarization) occurs 7-10 msec after the arrival of the conditioning volley to the cord and then quickly decays.4. A large antidromic field potential in the ventral horn is not necessary for the production of a centrifugal dorsal root discharge. Activation of a ventral root filament of approximately 100 mu in diameter can still induce such a discharge in a single dorsal root fibre. Furthermore, antidromic stimulation of the remaining fibres of the same ventral root cannot affect the terminals activated by the thin ventral root filament.5. The phenomenon of motoneurone-presynaptic interaction was obtained in different types of experimental preparations: acute and chronic spinal, anaemic and midcollicular decerebrate, animals with intact supraspinal centres, and one animal without acute laminectomy.


Use of radioactiv isotopes for continuous recording of increased vascular permeability in the rabbit ear.


Water uptake by the crab-eating frog Rana cancrivora, as affected by osmotic gradients and by neurohypophysial hormones. 1. The rate of water uptake across the skin was investigated in live Rana cancrivora, an euryhaline frog which has been reported to tolerate sea water. When they were exposed to distilled water at 29 degrees C, the rate of water uptake was 8.4 +/- 0.4 mul./cm(2).hr; when bathed in solutions ranging from 30 to 570 m-osmole/l., irrespective of whether the solute was sucrose, urea or NaCl, the rate of fluid uptake during the first day was inversely related to the osmolarity of the solution. No appreciable fluid movement was observed when the bathing solution had an osmolar concentration of 270 m-osmole/l.2. The rate of fluid uptake was not affected by injections of vasopressin, oxytocin or of extracts of amphibian or rat pituitary glands, irrespective of whether R. cancrivora were bathed in distilled water or in solutions of NaCl or sucrose.3. In Bufo melanostictus, in contrast with R. cancrivora, injections of neurohypophysial extracts produced a marked increase of the rate of fluid uptake.4. In the laboratory, R. cancrivora could be acclimatized stepwise to tolerate NaCl solutions up to 700 m-osmole/l. for 7 days.5. After 24 hr exposure either to distilled water or to NaCl solutions from 100 to 670 m-osmole/l., the osmolar concentration of the plasma of R. cancrivora was always higher than that of the bathing fluid. In R. pipiens or R. temporaria plasma osmolar concentration was higher than that of the bathing fluid only when the latter did not exceed 300 m-osmole/l.6. Under all conditions investigated, the osmolar concentration of the urine of R. cancrivora was always lower than that of the plasma.7. The amounts of pressor and oxytocic activities of pituitary glands of R. cancrivora kept in distilled water or in NaCl solutions up to 300 m-osmole/l. were 8.9 +/- 0.8 and 1.8 +/- 0.3 m-u./gland, irrespective of sex or body weight within the range 30-50 g. After 3 days exposure to hypertonic NaCl solutions, the amounts of pressor and oxytocic activities were 14.7 +/- 1.2 and 3.1 +/- 0.3 m-u./gland. In both instances the pressor/oxytocic ratio was 4.9. Pituitary glands of R. temporaria similarly showed increased pressor and oxytocic activities after exposure to NaCl solutions of 300-360 m-osmole/l.


On-line analysis of neuronal spike trains using a general purpose digital computer.


The influence of blood flow and hypoxia on free alpha-amino nitrogen transfer across the placental membrane.


Distribution of ions and electrical potential differences between mother and foetus at different gestational ages in goats and sheep. 1. Potential differences associated with the compartments of goat and sheep conceptuses have been measured in vivo and in vitro during the last half of gestation and the osmolarity, and the [Na(+)], [K(+)], and [Cl(-)] of maternal and foetal plasma and amniotic and allantoic fluid taken from these animals were determined.2. The potential difference (p.d.) patterns of both goats and sheep were the same.(a) The transplacental p.d. was about 71 mV (foetus negative) in the goat, and about 51 mV (foetus negative) in the sheep.(b) The amniotic fluid p.d. (i.e. the p.d. measured between the maternal extracellular fluid and the amniotic fluid) decreased as gestation advanced (from 110 to 70 mV in the goat, and 90 to 50 mV in the sheep) and was equal to the sum of the transplacental p.d. and a p.d. between the foetal blood and the amniotic fluid. The amniotic fluid was negative relative to both maternal and foetal blood.(c) An allantoic fluid p.d. (measured between the maternal extracellular fluid and the allantoic fluid) of about 107 mV in the goat, and about 96 mV in the sheep, was equal to the sum of the transplacental p.d. and a p.d. between the foetal blood and the allantoic fluid. The allantoic fluid was negative relative to both maternal and foetal blood.(d) The results suggest that p.d.s of the fluid sacs arise from activity between the foetal fluids and the blood perfusing the foetal membranes, and not from activity across the full thickness of the foetal membranes.3. The ionic concentrations were considered in relation to the electrochemical gradients found between the maternal and foetal fluid compartments to determine whether the ions were distributed according to electrochemical equilibrium.(a) It seems that ions in the amniotic fluid tend to equilibrate with foetal plasma, and not with maternal plasma or allantoic fluid, that changes in the [Na(+)] and [K(+)] of amniotic fluid can be accounted for largely in terms of passive factors, and that variations in the [Cl(-)] are associated with activity of an electrogenic Cl(-) pump directed from the foetal blood into the amniotic fluid.(b) It appears that ions in the allantoic fluid can exchange with those of both maternal and foetal plasma, that an electrogenic pump effects absorption of Na(+) from the allantoic fluid into the foetal blood, and that the [K(+)] and [Cl(-)] of allantoic fluid are maintained largely by passive exchange under the action of electrochemical gradients between maternal plasma and allantoic fluid, and between foetal plasma and allantoic fluid.4. The results considered in the context of Na(+) passage between mother and foetus call in question the general assumption that all Na(+) reaches the foetus by passing across the placenta.


Tremor of the wrist induced by positive velocity feed-back.


Voltage clamp experiments on ventricular myocarial fibres. 1. A voltage clamp method utilizing a sucrose gap and glass microelectrodes was developed and used to study dog ventricular myocardial fibre bundles. The limitations and the reliability of this method are demonstrated by a series of tests.2. A dynamic sodium current, excited at membrane potentials more positive than -65 mV, was measured. The equilibrium potential for this large, rapid inward current depends directly on [Na](o), shifting 29.0 +/- 2.3 mV (+/- S.E. of mean), as opposed to a theoretically expected value of 30.6 mV, when [Na](o) is reduced to 31% of normal.3. Sodium current is inactivated by conditioning depolarizations. Complete inactivation occurs with conditioning potentials more positive than -45 mV, and 50% inactivation occurs at about -55 mV. The location of the inactivation curve shifts along the voltage axis, when [Ca](o) is varied between 0.2 and 7.2 mM.4. A second, much smaller and slower net inward current, with a threshold around -30 mV, and an equilibrium potential above +40 mV was also observed.5. The ;steady-state' current-voltage relationship (after 300-600 msec) exhibits inward-going (anomalous) rectification with negative slope between -50 and -25 mV.6. A small, very slowly developing component of outward current was observed at inside positive potentials. The equilibrium potential for this current, although slightly dependent on [K](o), is neither identical with the potassium equilibrium potential nor with the resting potential in normal Tyrode solution.7. Anatomical limitations, primarily resistance in the extracellular space within the bundle, prevent complete characterization of the rapid, large sodium current, but do not limit the application of the clamp method to the study of other, smaller and slower currents. The evidence for this is discussed extensively in the Appendix.


The action of salicylate oa non-infective feer.


Membrane calcium current in ventricular myocardial fibres. 1. A slow inward current in ventricular preparations of the dog heart can be measured by the voltage clamp method without interference from the initial rapid sodium current if the sodium system is inactivated by conditioning depolarization.2. The slow inward current is very sensitive to variation in [Ca](o). It occurs above the equilibrium potential of I(Na) immediately after changing the bathing fluid to a sodium-free solution and persists under this condition for a long time without much alteration, while I(Na) is rapidly abolished. Tetrodotoxin and [Mg](o) have no effect on this current component. These results strongly support the view that the slow inward current in cardiac tissue is carried by calcium ions.3. The threshold for initiation of the calcium current is around -35 mV in Tyrode solution and is shifted to more negative potentials by either increasing [Ca](o) or reducing [Na](o).4. Calcium sensitive inward current tails associated with repolarization are assumed to represent a proportional measure of calcium conductance activated during the preceding depolarization. Calcium conductance declines rapidly with time in the inside negative potential range and slowly at positive potentials. The time constants for this ;inactivation' process vary between 40 and 700 msec in the potential range -35 to +50 mV.5. By using instantaneous current-voltage relations the reversal potential of calcium current was estimated to be about +60 mV in normal Tyrode solution. As shown in the Appendix, however, the calcium equilibrium potential cannot be considered to be constant.6. The importance of the calcium current for the plateau of the cardiac action potential is discussed.


Radiographic determination of leg fat, muscle and bone volums in male and female young adults.


The effects of distension of the pulmonary vein-atrial junctions upon peripheral vascular resistance. 1. Small balloons were inserted through the left pulmonary veins so as to lie at the pulmonary vein-left atrial junctions.2. Distension of the balloons caused a reflex increase in heart rate. The afferent path was in the vagus nerves and the efferent path was in the cardiac sympathetic nerves.3. Only small and variable changes in vascular resistance in a perfused hind limb accompanied the increase in heart rate when a steady state had been reached.4. In about half of the experiments a transient vasodilatation was observed in the perfused hind limb, occurring immediately after distension of the pulmonary vein-atrial junctions and lasting about 22 sec.5. The transient dilatation was due to a decrease in sympathetic vasoconstrictor nervous activity.6. Stimulation of left atrial receptors causes an increase of sympathetic nervous activity to the heart but does not cause a corresponding increase in sympathetic nervous activity to the hind limbs.


The direct and crossed components of the reflex release of catecholamines from the adrenal medulla of the dog following stimulation of the carotid body chemoreceptors.


Ion transport across isolated omsal epithelum of the sheep.


ircadian changes in sweating threshold.

ircadian changes in sweating threshold.


The relation between membrane potential, membrane currents and activation of contraction in ventricular myocardial fibres. 1. Membrane currents and contractile responses have been measured in ventricular myocardial preparations under voltage clamp conditions.2. In Tyrode solution, steady-state contraction was obtained only after 5-8 depolarizations to a given potential level. The threshold of steady-state tension was identical to the potential where the calcium inward current, I(Ca), was activated (about -35 mV). Both thresholds were shifted in the same direction along the voltage axis and by the same amount by changing [Ca](o) or [Na](o). Maximum tension was obtained at inside positive potentials.3. The time courses of steady-state tension and of activation of I(Ca) were different by more than one order of magnitude in Tyrode solution. But in order to achieve any appreciable steady-state tension, I(Ca) had to flow during several identical depolarizations. Tension decreased again at potentials above E(Ca). This suggests that calcium inward current must flow in order to fill intracellular calcium stores from which calcium can be released by an unknown mechanism.4. The ability of a fibre bundle to contract again after a preceding twitch is greatly dependent on the membrane potential between two equal depolarizations. In Tyrode solutions with 1.8 and 7.2 mM-CaCl(2) half restoration of this ability occurred at -45 +/- 3 mV (+/- S.E. of mean) and -23 +/- 4 mV, respectively.5. In sodium-free bathing solutions, steady-state tension was attained upon the first depolarization provided I(Ca) was activated. Furthermore, at different potentials, the time courses of activation of tension and of activation of I(Ca) were identical, i.e. tension reached its maximum when I(Ca) was fully activated. This suggests that in sodium-free solutions the flow of calcium ions into the fibre directly activates contraction.


Static compliance measurements in the adult human lung.


Storage effects in an oxygen electrode.

Storage effects in an oxygen electrode.


Carbohydrate metabolism in acidotic rats.


The effects of noradrenaline micro-iontophoretically applied on rabbit right atrium pace-maker cells.


The effects of nerve stimulation and hemicholinium on synaptic vesicles at the mammalian euromuscular junction. 1. Electron micrographs of nerve terminals in rat phrenic nerve-diaphragm preparations have been studied. This has been done before and after prolonged nerve stimulation. The effectiveness of nerve stimulation has been monitored by intracellular micro-electrode recordings from the muscle cells.2. Characteristic changes in the form and distribution of the nerve terminal mitochondria were noted after nerve stimulation.3. Synaptic vesicle numbers in the region of nerve terminal less than 1800 A from the synaptic cleft were significantly greater in tissue taken 2 and 3 min after nerve stimulation, than in unstimulated preparations.4. The long and short diameters of the synaptic vesicle profiles less than 1800 A from the synaptic cleft were measured. Analysis of the distribution of the diameters indicated synaptic vesicles to be basically spherical structures. Estimates of synaptic vesicle volume were made from the measurements. Synaptic vesicle volume was significantly reduced in tissue taken 2 and 4 min following nerve stimulation.5. If hemicholinium, a compound which inhibits acetylcholine synthesis, was present during the period of nerve stimulation, much greater reductions in synaptic vesicle volume occurred. Synaptic vesicle numbers in the region of nerve terminal less than 1800 A from the synaptic cleft were also reduced, compared with unstimulated control preparations.6. These results are regarded as support for the hypothesis that the synaptic vesicles in nerve terminals at the mammalian neuromuscular junction represent stores of the transmitter substance, acetylcholine.


The influence of insulin in promoting the survival and beating of intact foetal mouse hearts in organ culture.


Nucleotide requirements for Na:Na exchange by the Na pump.


Localization of the rate-limiting step in calcium absorption by rat intestine.


Pressure changes in different veins of the hand during venous occlusion plethysmography.


Passage of thyroxine across the placenta in the foetal sheep.