Sites of action of plant growth retardants on cholesterol biosynthesis by cell-free rat liver preparations.


Ultrastructure and differentiation of Hydrodictyon reticulatum. I. Mitosis in the coenobium.


Regulation of recombination at the his-3 locus in Neurospora crassa.


The development of hair follicles in the marsupial Trichosurus vulpecula.


Effect of incubation conditions on the metabolic response of ram spermatozoa in the presence of fluids from the genital tract of the ewe.


The morphology and motility of human synovial cells and their pericellular gels: a time-lapse microcinematographic study.


Fertilization and survival of fertilized eggs in the ewe following surgical insemination at various times after the onse of oestrus.


Some properties of red blood cell glucose-6-phosphate dehydrogenase from three species of kangaroo.


Uroporphyrinogen 3 cosynthetase activity in fibroblasts from patients with congenital erythropoietic porphyria.


Phosphoglucomutase (PGM) locus in Drosophila melanogaster: linkage and population data.


Glucose 6-phosphate dehydrogenase activity in the early rbbit and mouse embryo.


Production of hemoglobin C in the Moufflon (Ovis musimon Pallas, 1811) and the Barbary sheep (Ammotragus lervia Pallas, 1777) during experimental anemia: amino acid composition of tryptic peptides from the beta B and bet C chains.


Properties of placental alkaline phosphatase. I. Molecular size and eletrical charge of the various electrophoretic components of the six common phenotypes.


Uroporphyrinogen 3 cosynthetase in asymptomatic carriers of congenital erythpoietic porphyria.


Mitochondrial malate dehydrogenase and malic enzyme: Mendelian inherited electrophoretic variants in the mouse.


User services offered by medical school libraries in 1968: results of a national survey employing new methodology. The breadth and depth of services that ninety-two medical school libraries offer to individual users were ascertained by interviewing the heads of these libraries, employing a standardized inventory procedure developed earlier (Bulletin 56:380-403, Oct. 1968). Selected aspects of the descriptive data obtained on services to faculty and to medical students are presented and commented upon. Comparisons with the findings of earlier surveys suggest that increases in the staffs and budgets of medical school libraries over the past two decades have gone largely to supporting a rapidly increasing volume of service, rather than to any striking increase in the breadth and depth of services. To facilitate summarization and comparisions among libraries the descriptive data were weighted and converted to quantitative measures; the weighting scheme was established by a group of five academic medical librarians to reflect the relative values the group assigned to different services. One of these quantitative measures, the percentage score for overall services relative to the optimal library, summarizes a library's services in a single figure. On this measure, medical school libraries ranged from 38 percent to 87 percent; the median overall score was 63 percent. Results of some exploratory analyses are described; these analyses attempted to find explanations for the observed differences among libraries and among geographical regions on the quantitative measures. Present and potential uses of the survey data for managerial and research purposes are discussed. One of the most important of these uses is in establishing and implementing standards-activities which should be carried out by the library profession itself-and recommendations are made for a program of such activities that is appropriate for the Medical Library Association.


MLA committee membership: retrospect and prospect. MLA committee membership by category (medical school, society and hospital) for the past three years is examined revealing a heavy reliance upon medical school librarians for committee members. A ten-year examination of committee membership and turnover in individual committee membership rosters points out those committees whose rate of turnover is greatest. Opportunities for service by new MLA members is examined as is committee tenure as experienced during the last decade. Turnover, tenure, and frequency of leadership is examined for the ten-year period. Pointing out that only 360 individuals have served MLA in committee positions listed in the Bulletin, the Ad Hoc Committee to Review the Goals and Structure of the Medical Library Association is urged to more actively seek the opinions of the membership and to consider the service patterns of the past in recommending a course for the future.


An investigation of the educational needs of health sciences library manpower. II. Health-related institutions and their library resources. As part of an investigation of health sciences library manpower, the universe of health-related institutions and programs (excluding hospitals) was surveyed by postcard questionnaire to produce an inventory and description of libraries providing services to these institutions and programs. Seventysix percent (5,215) of the institutions reported access to library resources, indicating usage of some 2,207 non-hospital libraries. Eighty percent (2,431) of the institutions reported that the library used was "within" their own institution; 20 percent (608) noted that the library was "outside" of their institution. The distribution of health-related institutions and libraries is shown by RML districts, together with relevant census data. A classification of libraries, based on the degree of involvement of the libraries' facilities, resources and personnel in supplying services to health-related institutions, was developed. It is concluded that projections of manpower needs should take into account institutions and programs not at present possessing health sciences libraries as well as documented demand in existing health sciences libraries.


The Royal Medical Society of Edinburgh: sale of its library at Sotheby's. The library of the Royal Medical Society of Edinburgh, which has been in existence for nearly 250 years, was sold by Sotheby & Co. of London at three auction sales during 1969. The author describes her attendance at the three sales, with emphasis on the most valuable items sold and the considerable acquisitions made for the Middleton Medical Library of the University of Wisconsin. Concluding observations concern some of the practical problems of acquiring antiquarian books at auction.


Circulation policies in health science libraries. There is general agreement that library policies have considerable influence on the use of libraries. Medical school (health science) libraries of this country were surveyed as to their policies in respect to whether faculty and student use were regulated by a single policy, circulation regulations, hours library was accessible to users, accessibility of reserve material, interlibrary loan, policy on overdue material, and exit control. THE LIBRARIES WERE THEN DIVIDED INTO THREE GROUPS, HIGH, MIDDLE, AND LOW ACCORDING TO THE FOLLOWING CHARACTERISTICS: size of student body, size of faculty, size of holdings, size of library staff, annual budget, and annual circulation. Our findings would indicate that schools falling in a high category based upon these criteria tend to be more restrictive in their policies and to have different regulations for faculty and students than do schools in the low category.These findings warrant further study.


Medical school libraries and the "new" curriculum. The growing recognition of the need for humanities taught in schools of medicine is affecting acquisitions policies of medical libraries. This paper presents results of a survey conducted in various medical school libraries to evaluate the availability of humanities literature in their collections.


The nature of the use and users of the Midwest Regional Medical Library. Using a 10 percent random sample of all requests submitted to the Midwest Regional Medical Library during 1968-1969, this study has revealed that physicians constitute the user group making the most requests, that physicians request periodical materials most, that 86.6 percent of materials requested were for periodicals, and that over one-third of materials requested was more than ten years old. It was found that 66.3 percent of requests were filled, that "Pathology, Diseases, and Treatment" was the subject category with the highest percentage of requests, and that this category and Materia Medica were the subjects accounting for over 50 percent of the requests from all users. The subject categories most frequently requested by physicians were found to be the same (Pathology, Diseases, and Treatment and Materia Medica) as for educators and researchers. The most requests from students were in the Materia Medica and "other" subject categories. These findings are significant for drawing up acquisition policy for both the John Crerar Library, which supplies the physical facilities for the MRML, and the borrowing library which submits the requests for users.


Hospital libraries: focal point in the continuing education crisis. The Proposed Requirements for Professional Libraries in Hospitals to be Licensed in the Commonweath of Pennsylvania are presented and discussed. Indication is given of current trends in the development of hospital libraries as the single most important factor in continuing medical education and as the least-developed factor.


Birth of a foundation.

Birth of a foundation. In order to attract competent students with backgrounds in biology to the field of medical librarianship, the Medical Library Group of Southern California decided to expand their scholarship program. Funds were appropriated to establish a nonprofit, tax exempt foundation whose objective is to provide two full annual scholarships for the Master's degree program in librarianship. Details of the procedure followed in establishing the foundation are described along with criteria for selecting students.


Hospital library cataloging.

Hospital library cataloging.


SUNY-MEDLARS.

SUNY-MEDLARS.


Responsibility--institutional or individual.


Periodical prices.

Periodical prices.


Certification reform.

Certification reform.


Dispersion of the literature.

Dispersion of the literature.


TALON.

TALON.


President's page.

President's page.


Tests of a model of binocular brightness.


The generality of color-form preference as a function of materials and task requirements among lower-class Negro children.


Simple reaction time to cutaneous temperature stimuli.


An analysis of transfer along a continuum.


The relationship betweenuditory and visual short-term memory and reading achievement.


Children's use of context in judgment of weight.


Neonate-mother interaction: effects of parity on feeding behavior.


Perceptual exploration in Israelihildren.


The relationship between intentional learning, incidental learning, and type of reward in preschool, educable, mental retardates.


Attentional responsesof five-month girls to discrepant auditory stimuli.


A note on selective imitation by a six-week-old infant.


The ability of prsonality variables in discriminating among three intellectual groups of preadolescent boys and girls.


Educationl intervention at home by mothers of disadvantaged inants.


Infant mental development and neurological status, family socioeconomic status, and intelligence at age four.


A reexamination of some assumptions about the language of the disadvantaged child.


Verbal factors in compensation performance and the relation between conservation and compensation.


Children's seective attention to stimuli: stage or set?


Young children's orientation of letters as a function of axis of symmetry and stimulus alignment.


Studies on the kynurenine transaminase of Schistocerca gregaria forsk. (Orthoptera, Acrididae).


Lipid composition of the egg exteriors of the chicken (Gallus gallus).


Time-lapse photographic studies of cockroach hemocyte migrations in vitro.


Induction of nucleolar segregation by actinomycin D following inhibition of protein synthesis with cycloheximide.


Electron probe analysis of calcium distribution during active transport in chick chorioallantoic membrane.


Subpopulations within "short-lived" and "long-lived" lymphocytes resolved by isopycnic sedimentation in Ficoll solutions coupled with a double radioisotopic labeling technique.


Early stimulation of potassium uptake in lymphocytes treated with PHA.


UV-absorption and quinacrine mustard fluorescence patterns for chromosome aberration study in Chinese hamster.


Identification of the flagellar proteins of Chlamydomonas reinhardii.


Diagnostic procedures in hypopituitary dwarfism. I. Evaluation of growth hormone deficiency: plasma growth hormone response to insulin-induced hypoglycemia, effect of HGH on nitrogen retention, insulin-tolerance-test and growth velocity.


Plasma growth hormone determination in the Silver-Russell syndrome.


Fatal familial granulomatosis in children.


Utilization of capillary blood for serum enzyme analysis.


Beyond the clinical cocoon: community mental health in the university.


Clinical pharmacy at the University of Cincinnati.


Roommate compatibility in freshmen women.


Report of a preliminary study of pregnancy on the university campus.


Case finding with minifilm chest x-ray.

Case finding with minifilm chest x-ray.


Findings of the ACHA family life-sex education study.


Features of a medical records information system: results of a survey.


The role of electronic data processing in the evaluation of college health programs.


Rheumatic fever and rheumatic heart disease on campus--1956-1969.


Sensitivity training and the university.


Typhoid epidemic at Stanford University.


March hemoglobinuria treated with rubber insoles: two case reports.


Nutritional considerations for Americans living in the tropics.


Problems of foreign students: an overview.


A hunger strike on campus.

A hunger strike on campus.


Education for health behavior: a philosophical model.


Criteria for administration. VI. The director and T-W C.


Criteria for administration. V. The director and compliance.


Vigilance performance under hypoxia.

Vigilance performance under hypoxia.


Sensory-feedback persistence in determining memory.


Arousal, monotony, and accidents in line driving.


Delayed retinal feedback of eye movements: a dynamic basis of perceptual disabilities.


Predicting vocational outcome of psychiatric patients with the Edwards Personal Preference Schedule.


Cells containing Birbeck granules (Langerhans cell granules) in the human thymus.


Crystal bodies in the outer plexiform layer of the human retina.


Depth perception from motion parallax in one-dimensional polar projections: projection versus viewing distance.


Error-produced frustration as a factor influencing the probability of occurrence of further errors.


Influence of frequency on the estimation of time for auditory, visual, and tactile modalities: the Kappa effect.


Auditory pattern perception: processing limits and organizational tendencies.


Unimodal and multimodal sequential information processing in normals and retardates.


Time course of visual and auditory encoding.


Energy integration in intersensory facilitation.


Eye elevation and visual space in monocular regard.


Effects of an irrelevant auditory stimulus on visual choice reaction time.


Acid-labile (amide) nitrogen metabolism of brain proteins.


Tryptophan transport across the synaptosomal membrane.


Colchicine-binding activity in particulate fractions of mouse brain.


The activation of thiamine diphosphatase by ATP in rat brain.


The incorporation of isotopic carbon 14C into the cerebral glycogen of normal and x-irradiated rats.


Choline acetyltransferase in individual neurons of Aplysia californica.


Preparation of DNA and four different RNA species from rat brain. A new RNA fraction and a new characteristic of the various RNA's.


Personal space as influenced by sex and type of movement.


Putreanine in human brain.

Putreanine in human brain.


Monocular and binocular estimations of distance when knowledge of the relevant space is absent.


Aspirations and concerns of hospitalized sychiatric and medical casualties evacuated from the republic of Vietnam.


Population pollution.

Population pollution.


Effect of stimulus presentation on free recall of reflective and impulsive Mexican-American children.


Self-ideal congruence as a function of human relations training.


Correlates of eidetic imagery in Africa.


Mental illness in four cultures.

Mental illness in four cultures.


Ethnocentrism and acculturation of North Americans in Guatemala.


A comparative study of intercultural insightand empathy.


Effects of leadership and other inputs on group processes and outputs.


Authoritarianism and evaluation of appropriateness of role behavior.


The effect of academic integration on the self-esteem of southern Negro students.


Leader LPC scores: attitude dimensions and behavioral correlate.


Evidence of construct and criterion-related validity for the self-concept.


Some cultural determinants of suicide in Sweden.


Temporal orientation and academic achievement in college.


Group influence on ethical risk taking: the inadequacy of two hypotheses.


Creativity, authoritarianism, and birth order.


The relationship between birth order and leadership style.


Dogmatism and intolerance for sensory discrepancy.


Authoritarianism and race attitudes in South Africa.


Caste prejudice and its perception by Harijans.


Creative thinking ability and susceptibiltiy to persuasion.


Feasibility of Cloze techniques for teaching and evaluating culturally disadvantaged beginning readers.


The structure of parents intrafamilial attitudes and sentiments measured by objective tests and a vector model.


Relationships between various criteria of leadership in small groups.


Fear and affiliation during a disaster.

Fear and affiliation during a disaster.


Sex and age differences in persuasibility.


Some personality differences between seminarians and nonseminarians.


Cognitive stages in dream concept development in English children.


In vitro recognition of diethylstilbestrol by anti-azobenzyl estradiol IgG.


Poststerone, a metabolite of insect metamorphosing substances from Cyathula capitata.


A comparison of the effects produced by metyrapone and its reduced metabolitonheadrenal 11-beta-hydroxylase systm in the rat.


Sustained release hormonal preparations. 12. Plasma levels of 6-methyl-17-alpha-acetoxy-4,6-pregnadiene-3,20-dione in hamsters.


Effects of norethynodrel on the tissue distribution of H3-estradiol- 17-beta in ovariectomized rats.


The management of esophageal wounds.

The management of esophageal wounds.


Benign duodenal tumors: unusual surgical problems.


Reconstructive surgery of the colon in soldiers injured in Vietnam.


Ileosigmoid knotting.

Ileosigmoid knotting.


Traumatic rupture of the right main bronchus in an eight-year-old child successfully repaired eight years after injury.


Long-term appraisal of aortic and arterial homografts implanted in years 1954-1957.


Saphenous vein bypass grafts to the arteries of the ankle and foot.


Effect of hyperglycemia on cardiac tolerance to normothermic anoxia arrest during cardiopulmonary bypass in dogs.


Acid base changes associated with topical Sulfamylon therapy: retrospective study of 100 burn patients.


Relationship of biliary phospholipid and cholesterol concentrations to the occurrence and dissolution of human gallstones.


The effect of thermal injury on serum immunoglobulins.


Chronic afferent loop syndrome.

Chronic afferent loop syndrome.


Necrotizing fasciitis.

Necrotizing fasciitis.


Plasma cortisol levels after head injury.


Adenocarcinoma of the colon associated with severe hypokalemia: report of a case.


Hydrocarbons, free fatty acids, and amino acids of sclerotia of Sclerotinia sclerotiorum.


Hydroxylations of aromatic amino acids mediated by a tetrahydropterin.


A re-examination of the equations appertaining to sedimentation equilibrium.


Effects of antibiotic substances on the respiration of yeast grown in 1 percent glucose.


Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin.


A possible role for the species peroxonitrite in nitrification.


Differential assay of human hexosaminidases A and B.


Effects of aflatoxin on some marker enzymes of lysosomes.


Structure-activity relationships among the aminoglycoside antibiotics: comparison of the neomycins and hybrimycins.


The effect of imidodiphosphate (P-N-P) on the precipitation and dissolution of calcium phosphate in vitro.


Physicochemical properties of the active fragments of M and N group mucoproteins from human erythrocytes.


Formation of dibutylphthalate from 2-butyne-1,4-diol by a soil bacterium.


Separation of blood coagulation factors II, VII, IX and X by gel filtration in the presence of dextran blue.


Reproducibility of analysis of the electrocardiogram in epidemiology using the 'Minnesota code'.


Correlation of weight-height index with diastolic and with systolic blood pressure.


Patterns of respiratory illness in Sheffield junior schoolchildren. A follow-up study.


Cross-cultural analysis of selected emotional questions from the Cornell Medical Index.


Patients on the waiting list of a London teaching hospital.


Factors affecting response to postal questionnaires.


Median cerebrofacial dysgenesis.

Median cerebrofacial dysgenesis.


Technique, rationale, and usefulness of bedside right heart catheterization in critically ill cardiac patients. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs. Martin J. Cline and Hibbard E. Williams, Associate Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.


Differentiation of extrahepatic and intrahepatic obstructive jaundice.


A policy on strikes.

A policy on strikes.


Therapeutic effects of hypothermia upon intestinal obstruction with special reference to the cause of death.


The use of autosuture instrument in gastro-intestinal surgery.


New diagnostic method for the postoperative disorders of intestine.


Medicine's place in aviation safety.

Medicine's place in aviation safety.


Treatment of hypertension.

Treatment of hypertension.


Some psychiatric comments on the current move toward sex education programs in the schools.


Relations of heart rate to motor activity and arousal in the rat.


CS and UCS intervals and orders in human autonomic classical differential trace conditioning.


Leiomyosarcoma of Meckel's diverticulum.


Effect of age and test situation on reinstatement of fear.


Crohn's disease of the rectum.

Crohn's disease of the rectum.


Improved avoidance performance following exploratory movement.


Carcinoma of colon and rectum with reference to longterm survival.


Choledochoduodenostomy, why and when.

Choledochoduodenostomy, why and when.


4-amino-imidazole-5-carboxamide excretion and folate status in children with burns and scalds.


Serum trehalase: assay and normal values.


A comparative study of choledochoenterostomy and transduodenal sphincterotomy in the management of benign extrahepatic biliary tract obstruction.


An experimental hepatorenal syndrome.

An experimental hepatorenal syndrome.


Volatile fatty acids in normal human physiological fluids.


Enzymatic abnormality of the carrier state in metachromatic leukodystrophy.


An assessment of the use of sephadex G-25 in the estimation of serum protein-bound magnesium and calcium.


A method for the determination of plasma guanase on finger-tip blood.


A rapid fluorimetric method for the determination of dopamine in urine.


Rat and human seromucoid under normal and certain pathological conditions.


Leukocyte alkaline phosphatase in pregnancy. Comparison with placental phosphatase activity.


An automated method for urinary oestriol determination.


Utilization of ion-exchange chromatography in the isolation and colorimetric assay of p-aminophenyl glucuronide derivatives in human urine.


Polymeric binding of haemoglobin in cattle.


Patterns of urinary enzyme excretion in healthy subjects.


Renal effects of streptomycin in rats.

Renal effects of streptomycin in rats.


Comparison of fecal urobilinogen excretion with bilirubin production in normal volunteers and patients with increased bilirubin production.


The quantitative estimation of oestriol using gas-liquid chromatography.


A rapid and simple method for the specific estimation of glucose in blood.


The effect of P O2 on the determination of P CO2 by the interpolation technique.


The determination of arylsulfatases in biological fluids.


A simple and clinically useful method for plasma testosterone-like substances by competitive protein binding.


A titrimetric method for the determination of actual bicarbonate in cerebrospinal fluid and plasma or serum.


The binding of 14C-labelled porphyrins by plasma proteins.


A simple and rapid semi-automatic micro method for the determination of chloride in serum and urine.


A semiautomated method for the determination of serum thyroxine (T4) without incineration.


Foreign profiles in air pollution control activities. Special sources of information.


A load shifting model for air pollution control in the electric power industry.


Relationship between time-span of discretion, leadership behavior, and Fiedler's LPC scores.


Studies on the removal of sulfur dioxide from hot flue gases as a measure to prevent air pollution. IV. Recovery of flue gas sulfur as ammonium phosphate.


Feedback factors in steering and tracking behavior.


Determination of sulphur in foodstuffs. II. Reduction to hydrogen sulphide.


Improved myo-electric control system.

Improved myo-electric control system.


Evaluation of total muscular activity by quantification of electromyograms through a summing amplifier.


The summation of muscle fibre action potentials.


The use of spectral analysis to determine the cortical adaptation time course from extracranially recorded responses in man.


A six channel scanning system for digital recording and analysis of pulmonary function data.


Eight channel scanning and timing controller for physiological data aquisition.


Determination of the modulus of elasticity of bone by a vibration method.


Comparative membrane ultrafiltration rates.


G.S.R. systems which aid data analysis.

G.S.R. systems which aid data analysis.


A simple millivoltmeter and electrodes for measurement of rectal electrical potential in man.


An inexpensive pulse transducer and cardiac tachometer.


A simple ultrasonic meter for measuring activity in small laboratory animals.


A method for triggering evoked potentials by a certain component of the background-activity.


A combined time base-event marker circuit for physiological research.


A digital tachystoscope.

A digital tachystoscope.


Inhibiion of the mold phase of Coccidioides immitis by beta-ionone and dimethoxane.


Fungi that cause mouldiness of processed sheet rubber in Western Nigeria.


Ploidy differences in Cryptococcus albidus.


Susceptibility of laboratory animals to Blastomyces dermatitidis using different routes of inoculation.


The role of repeated administration of suckling mice with urethan on carcinogenesis.


Experimental study on cerebral circulation and ultrasonic attenuation in dog.


Cytogenetic aspects of habitual abortion. 1. Chromosome analysis of couples with history of habitual abortion.


Cytogenetic studies in the gynecological field. 1. ytogenetic studies on primary amenorrhea.


Cytogenetic aspects of habitual abortion. 2. Observation of satellite association in couples with history of habitual abortion.


[Cytogenetic studies in the gynecological field. 2. Cytogenetic studies on primary sterility].


Human discrimination learning: the subset-sampling assumption.


Individual differences in figural aftereffects.


Peripheral physiological variables and emotion: the James-Lange theory revisited.


Sexual dimorphism and homosexual gender identity.


X-ray film processing economiser.

X-ray film processing economiser.


A survey of silver recovery. I. The mechanics of silver recovery.


Radiography: challenge and responsibility.


A patient's view of radiotherapy.

A patient's view of radiotherapy.


The hospital radiographer--a profile.

The hospital radiographer--a profile.


A new school of radiography at Bradford.


The Balkanization of allergy.

The Balkanization of allergy.


Arterial blood pH.

Arterial blood pH.


The ignored or unknown variables of the pollution syndrome.


Regional variation in the cycle time of cells in epiphyseal cartilage.


A new look at biochemical tests of liver function.


Purification of human lymphocytes by simple centrifugation.


Hormonal response to intra-venous fructose in normal and fructosaemic children: a study of insulin and growth hormone secretion.


Synthesis of nueic acids and proteins in the dimorphic forms of Candida albicans.


Tinea capitis in North India.

Tinea capitis in North India.


Effect of hair oils and fatty acids on the growth of dermatophytes and their in vitro penetration of human scalp hair.


In vitro an in vivo protein synthesis in Candida albicans. I. Isolation and protein synthesis of polysomes.


In vitro and in vivo protein synthesis in Candida albicans. 2. Dissociation properties of ribosomes.


In vitro and in vivo protein synthesis in Candida albicans. 3. Protein synthesis and inhibition.


Cysteine oxidation and annulment of amphotericin B inhibition of Coccidioides immitis.


Germination of blastospores of Histoplasma capslatum.


Effect of sirepar on experimental cirrhosis in rats.


Clinical observations concerning Uregyt, a Hungarian diuretic preparation of ethacrinic acid.


Efficiency of Phlogosam in the treatment of eczema.


Laboratory analysis and clinical evaluation of a new amino-penicillin preparation (Semicillin).


Treatment of vascular diseases with Mydocalm.


Discrimination learning as a function of MA, IQ and institutionalization.


Effectiveness of counselor-trainees with mentally retarded sheltered workshop clients.


A comparison of broken home and stable home retardates on selected variables.


Three summers: experiments in temporary residential care of retardates.


Independence programming among institutionalized retarded young adults: an anecdote, and comment.


Procedures for evaluating physical functioning in trainable mentally retarded children.


A review of the development of work-study programs for the mentally retarded.


Factors in an adaptive behavior check list for use with retardates.


Withdrawal of social reinforcers as a means of controlling rumination and regurgitation in a profoundly retarded person.


A novel group approach to school counseling of educable retardates.


The blind retardate--three program suggestions.


Programming for educable mentally retarded children.


Lesions in nervous tissue and bone in ataxic vitamin A deficient quail.


Neuropathological and neurochemical studies of three cases of sudanophilic leucodystrophy.


[Foramina parietalia permagna as a familial developmental defect].


Direct and rapid description of the individual ionic currents of squid axon membrane by ramp potential control. Computations based upon the Hodgkin-Huxley equations and experimental data from squid axons show that ramp functions can be used as commands to a voltage clamp system to selectively observe either the fast (sodium) or slow (potassium) process in axon membranes without chemical separation techniques or computer assistance. Each process is characterized directly (on line) and rapidly (real time) by generating a current-potential curve on an oscilloscope for fast or slow rates of change of membrane potential (ramps). The speed and directness of this method of characterizing each of the essential axonal events permit quantitative measurement of the kinetics of rapid effects on these processes due to various pharmacological agents such as tetrodotoxin and tetraethylammonium ion or other experimental changes in the membrane environment.


Conduction mechanisms in Lillie's iron-wire model of nerve. Based on theory and experiment, we found that the conduction through the oxide film in Lillie's iron-wire model is dominated by Schottky emission at low fields (below 10(6) v/cm), by electron tunneling from trap to trap at intermediate fields and by direct tunneling (Fowler-Nordheim type) at higher fields (above 3 x 10(6) v/cm). The trap-to-trap tunneling is considered to give rise to the negative resistance and the fixed position of the current maximum as observed. Some of the nervelike properties of the Lillie's model are interpreted on this tunneling mechanism.


Spin-echo nuclear magnetic resonance evidence for complexing of sodium ions in muscle, brain, and kidney. Na(+) in muscle, brain, and kidney is shown by spin-echo nuclear magnetic resonance (NMR) to consist of two fractions with different NMR parameters. The slow fraction of Na(+) in these tissues has NMR relaxation times T(1) and T(2) of 10-15 x 10(-3) sec, which is approximately 4-5 times shorter than for Na(+) in aqueous NaCl solution. The slow fraction may represent Na(+) dissolved in structured tissue water. The fast fraction of tissue Na(+), which is shown to represent approximately 65% of the total tissue Na(+) concentration, has T(2) less than 1 x 10(-3) sec, which resembles the values of T(2) observed for Na(+) complexed by synthetic ion-exchange resins. One is drawn to the conclusion that approximately 65% of total Na(+) in muscle, brain, and kidney is complexed by tissue macromolecules.


An electrokinetic model of transduction in the semicircular canal. Transduction in the semicircular canal was studied by focusing an infrared beam on either side of exposed ampullae from the posterior canals of Rana pipiens. The direction of fluid movement resulting from a stimulus was inferred by observing the polarity of the change in afferent impulse mean rate relative to the spontaneous value. On the basis of the accepted functional polarization of this receptor, the results indicate that fluid moved toward the warmer side of the ampulla. Convection and thermal reception were shown to be unlikely explanations for these results. Morover, cupular displacements toward the warmer side would not be expected. Because thermo-osmosis can cause fluid to move toward the warmer side in a gelatin membrane, the results can be interpreted as evidence that thermo-osmosis occurred in the gelatinous cupula and influenced the transduction mechanism. Thermo-osmosis of liquids appears to be due to an electric field that is set up in a charged membrane; hence, the hair cells might have detected an electric field that occurred in the cupula during thermo-osmosis. Electroreception might be an important link in the transduction of physiological stimuli also. Rotational stimuli could result in weak electric fields in the cupula by the mechanoelectric effect. Cupular displacements could be important for large stimuli, but extrapolations to threshold stimuli suggest displacements of angstrom amplitudes. Therefore, electroreception by the hair cells could be an explanation of the great sensitivity that has been observed in the semicircular canal and other labyrinthine receptors.


Some peculiarities of water transport through plasticized nonporous membranes. "Liquid" and "plasticized" solvent membranes are of interest as possible analogues of biological systems. Semipermeable homogeneous films are prepared by plasticizing polyvinylchloride with organic phosphates. Water permeability of such films is relatively high. For a material containing 70% of 1.4-dihydroxyphenyl-bis(dibutylphosphate), the diffusion coefficient of water at room temperature was estimated to be about 1 x 10(-6) cm(2)/sec. Conditioning of a plasticized membrane, under the osmotic gradient of solution of sodium nitrate, leads to profound changes in its morphology and to a drastic increase of its water permeability. The induced changes are reversible to a large extent. Their reversibility in various solutions may be correlated with the respective differences in permselectivity. The structure of expanded membranes and the mechanism of changes taking place under the osmotic gradients are discussed.


Sulfhydryl and disulfide groups in HeLa cells.


A theory of necrotaxis.

A theory of necrotaxis. A mathematical theory for the motion of polynuclear leukocytes after the laser irradiation of a red blood cell is derived and compared with the measured movement of a number of cells. An estimate is made on the diffusion constant and the molecular size for the unknown material which communicates the information on the irradiation of the red blood cell to the leukocyte.


On the possibility of nonthermal biological effects of pulsed electromagnetic radiation. Two mechanisms for the interaction of alternating electrical fields with biological tissue are the development of heat, via i(2)R losses, and field-induced force effects, via differences in passive electrical properties. It has been shown that for continuous wave (CW) fields in media of physiologic electrical conductivity, the development of heat (>1 degrees C) always precedes the possible appearance of a field-induced force effect. Using pearl-chain formation as a model effect and experimentally demonstrating that its time constant varies inversely as the square of the electrical field strength, we show that a pulsed field has no greater ability than a CW field of equal rms field strength to produce a field-induced force effect. Thus, the statement above for CW fields can be broadened to include pulsed fields of any description. By relating incident power density to electric field strength in tissue, we show that the American National Standards Institute's radiation protection guide obviates the production of genetic effects in man, if they exist, via field-induced force effects.


Pyramidal modulation of responses of spinal neurons to natural stimulation of cutaneous receptors.


Oculomotor influences on lateral geniculate body neurons.


Differences in the electrophysiological correlates upon receipt of a food reard and nonreward i the rat.


The distribution of 5'-nucleotidase in subcellular fractions of mouse cerebellum.


Ultrastructural stability of contact regions of phospholipase-treated synapses from rat motor cortex.


Changes in the concentrations of the two brain specific proteins, s-100 and 14-3-2, during the development of the avian optic tectum.


Effects of cortical and thalamic lesions on temperature discrimination and responsiveness to foot shock in the rat.


Aspects of the biliary excretion of orphenadrine and its N-demethylated derivative, tofenacin, in the rat.


The metabolic fate of 3H-fenetylline in man.


Increased synthesis and release of dopamine in the striatum of the rat after amantadine treatment.


Depressant effect of delta-1-tetrahydrocannabinol enhanced by inhibition of its metabolism.


The effect of some oral hypoglycaemics on the gamma-aminobutyric acid content in the cerebral hemispheres of adult male mice.


Hypnotic activity of centrally--administered barbiturate and uncouplers of oxidative phosphorylation.


Chronic administration of trifluoperazine in multiple dosages and multiple durations.


Iron, copper, and zinc in rat brain.

Iron, copper, and zinc in rat brain.


Formation of a quaternary derivative in mouse brain after administration of N-(5'-chloropentyl)-N-methylaminoaceto-2,6-xylidide.


Distribution of norepinephrine released from adrenergic motor terminals in arterial wall.


Actions of neurohypophysial hormone analogues on perfused isolated rat caudal artery.


Membrane stabilization and cardiac effects of d,1-propranolol, d-propranolol and chlorpromazine.


Effects of ergotamine and dihydroergotamine on uptake of 5-hydroxytryptamine in blood platelets.


Drug-induced changes of urinary catecholamines in the rat: role of the adrenal medulla.


Preventive effect of local heparin administration on microvascular pulmonary hemorrhages induced by cobra venom in mice.


Ultrastructural changes associated with reversible and irreversible suppression of electrical activity in olfactory cortex slices.


Further study on pharmacological properties of the cerebellar-induced inhibition of deiters neurones.


Glycogen accumulation in dendrites of the rabbit pallidum following trifluoperazine administration.


Simultaneous contrast, filling-in process and information processing in man's visual system.


Atypical mycobacteria in human disease. Review of literature with report of five strains isolated from cases of pulmonary tuberculosis.


Carcinoma of the ureter with thrombosis of inferior vena cava.


Mycological aspects of dermatomycosis in Hyderabad.


Experiences with percutaneous transhepatic cholangiography (P.T.C.) and review of cases of carcinoma pancreas met at General Hospital, Madras over last three-and-a-half years.


Augmented histamine test in cirrhosis liver.


Review of cases of amoebic liver abscess proven at aspiration over last five years.


Clinico-sigmoidoscopic presentation in non-specific ulcerative colitis.


Colon and disease.

Colon and disease.


Histopathological changes in serial liver biopsies in amoebic liver abscess.


Amoebic abscess of the lung. (A clinical study of 14 cases).


Requirement of cytidine derivatives in the biosynthesis of O-alkyl phospholipids.


Protein catabolism in rat liver homogenates. A re-evaluation of the energy requirement for protein catabolism.


Urea biosynthesis in a surviving amphibian liver cube preparation.


Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase.


Structural specificity of the adenosine 5'-phosphate site on glycogen phosphorylase b.


Studies of the electron transport chain of extremely halophilic bacteria. IV. Role of hydrophobic forces in the structure of menadione reductase.


Denaturation of globular proteins. II. The interaction of urea with lysozyme.


Kinetics of the reaction of hybrid-heme hemoglobins with carbon monoxide.


Kinetics of the reaction of the "masked" and "free" sulfhydryl groups of human hemoglobin with p-mercuribenzoate.


On the mode of action of lipid-lowering agents. 3. Kinetics of activation and inhibition of acetyl coenzyme A carboxylase.


Magnetic resonance studies on a gel of guanylic acid and a guanosine monophosphate-copper (II) complex.


The effects of altered brain norepinephrine levels on continuous avoidance responding and the action of amphetamines.


Comparative effects of amphetamine, scopolamine, chlordiazepoxide, and diphenylhydantoin on operant and extinction behavior with brain stimulation and food reward.


The effect of eserine on the efferent neuronal activity in the cervical sympathetic of the rat.


Evidence that gamma-aninobutyric acid is not the inhibitory transmitter at the crossed olivocochlear nerve-hair cell junction.


Cerebrospinal fluid 5-hydroxyindoles and behavior after L-tryptophan and pyridoxine adminstration to psychiatric patients.


Effects of pentobarbitone and chlorpromazine on acoustically evoked potentials in the rat.


Analysis of iodine-131 data in bovine thyroids, October 1964 through February 1969.


Results of 33,911 x-ray protection surveys of facilities with medical or dental diagnostic x-ray equipment, fiscal years 1961-1968.


Preliminary survey of x-ray producing devices in Kansas schools, 1968.


Food and diet surveillance. I. Estimated daily intake of radionuclides in California diets, April-December 1969, and January-June 1970.


2. Radionuclides in institutional diet samples, January-March 1970.


Tritium in surface water network January-June 1970.


Radioactivity in airborne particulates and precipitation.


1. Radiation alert network July 1970.

1. Radiation alert network July 1970.


. Canadian air and precipitation monitoring program, July 1970.


3. Mexican air monitoring program July 1970.


4. Pan American air sampling program July 1970.


Environmental levels of radioactivity at Atomic Energy Commission installations.


Induction of the Schultz-Dale reaction at low temperature.


Physiopathological correlation between hitoogical alterations and bioelectrical modifications of the retina in experimental hypobarism.


Assessment and outcome.

Assessment and outcome.


Facing the new challenge.

Facing the new challenge.


Art, play and slow learners.

Art, play and slow learners.


'Not see you Monday'.

'Not see you Monday'.


Education of mentally handicapped children.


The teacher and the clumsy child.

The teacher and the clumsy child.


Concurrent exponential growth and death of cell populations of Saccharomyces cerevisiae at superoptimal growth temperatures.


An attempt at modelling of the central alimentary system in higher animals. I. Physiological organization of the alimentary system.


An attempt at modelling of the central alimentary system in higher animals. 3. Some theoretical problems concerning identificationand modelling of the simple neural structures.


An attempt at modelling of the central alimentary system in higher animals. IV. Experiments on classical conditioning.


An attempt at modelling of the central alimentary system in higher animals. V. Instrumental conditioned reflexes.


Influence of acid-base changes on isolated human foetal hearts.


Influence of mepivacaine on isolated human foetal hearts at normal and low pH.


Influence of contraction rate, coronary perfusion pressure and diastolic pressure on the mechanical performance of isolated human foetal hearts.


The conservation of number, mother, water and a fried egg chez l'enfant.


Studies of visual backward masking and a model for the Crawford effect.


The influence of margins on visual after-effects in the third dimension.


The exploration of transition rules in conservation of quantity (substance) using film mediated modeling.


The diminishing time-uncertainty with the lapse of time after the warning signal in reaction-time experiments with varying fore-periods.


The effect of extraversion and stimulant and depressant drugs on verbal conditioning.


Verbal communication length as an index of interpersonal attraction.


The generality of social perception characteristics.


The boundaries of entoptic space and Emmert's law.


Constancy and contrast 3c.

Constancy and contrast 3c.


Further observations of a modified elastic support for stasis and stasis ulcers of the legs.


Ultrasound as an aid in the diagnosis and management of intermittent claudication.


Functional segmental plethysmography. Clinical application and results.


Angiographic demonstration of pulmonary venomotor reactions in the intact dog.


Separation of shock types. Experimental and clinical separation of hypovolemic and septic shock.


Alterations in catalytic and regulatory properties of glutamate dehydrogenase resulting from reaction with one molecule of 14C-labeled methylmercuric iodide.


Studies on the subunit structure of thermostable glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus.


Vitamin K activity of phylloquinone oxide.


Formation and life cycle of ribosomal subunits, mono- and polyribosomes in Bacillus licheniformis.


A modified microdiffusion procedure for the growth of single protein crystals by concentration-gradient equilibrium dialysis.


Ribosomes of Saccharomyces cerevisiae, strain LK2G12, and of other yeasts.


Small-angle light scattering of bioparticles. 3. Vaccinia virus.


Localization of the monoglyceride pathway in subcellular fractions of rat intestinal mucosa.


Influence of degradative procedures, salts, respiratory inhibitors, and gramicidin on the binding of cytochrome c by liver mitochondria.


Effects of cortisone on orotic acid transport and RNA synthesis in rat liver.


Anion inhibition of firefly luciferase.

Anion inhibition of firefly luciferase.


Photolysis of dansyl amino acids and dansyl peptides.


Characterization of two circular satellite species of deoxyribonucleic acid in Rhodopseudomonas spheroides.


Studies on pituitary lactogenic hormone. XXX. The primary structure of the sheep hormone.


The biosynthesis by brain microsomes of cerebrosides containing nonhydroxy fatty acids.


A soluble amino acid-incorporating system from the fat-rich supernatant fractions of rat liver.


Non-protein amino acids in Australian seaweeds.


Can scalp hair suddenly turn white? A case of canities subita.


Erythema chronicum migrans.

Erythema chronicum migrans.


A flagon of yeast.

A flagon of yeast.


Candidiasis, vitiligo, Addison's disease, and hypoparathyroidism.


Sarcoidosis.

Sarcoidosis.


Pemphigus vulgaris.

Pemphigus vulgaris.


Vasculitis.

Vasculitis.


Primary amyloidosis involving lip, gums and salivary glands.


Lichen amyloidosus.

Lichen amyloidosus.


Diffuse normolipemic xanthomatosis.

Diffuse normolipemic xanthomatosis.


Xanthomatosis, associated with multiple myeloma.


Elastosis perforans serpiginosa.

Elastosis perforans serpiginosa.


Multiple melanocytoma.

Multiple melanocytoma.


Elastosis perforans serpiginosa vs Kyrle's disease.


The cutaneous amyloidoses. II. Systemic forms.


Urticaria pigmentosa discordant in identical twins.


Mercury pigmentation. An electron microscopic study.


Evaluation of two new color indicator media for diagnosis of dermatophytosis.


North American blastomycosis presenting as an acute panniculitis and arthritis.


Electron transfer during sulphide and sulphite oxidation by Thiobacillus concretivorus.


Low-temperature (4-77 degrees K) spectroscopy of Chlorella: temperature dependence of energy transfer efficiency.


Characterization of chloroplast photosystems 1 and 2 separated by a non-detergent method.


The plastocyanin content of chloroplasts from some higher plants estimated by a sensitive enzymatic assay.


A spectrophotometric method for the quantitative estimation of intact (Class I) chloroplasts.


II. Effect of ionophorous antibiotics in chlorplasts.


Determination of the concentration and the redox potential o chloroplast cytochrome 559.


Energy utilization by mammalian fast and slow muscle in doing external work.


The phosphate potential generated by membrane fragments of Azotobacter vinelandii.


Oxidative phosphorylation in Azotobacter vinelandii. Atebrin as a fluorescent probe for the energized state.


The sensitivity of dicarboxylate anion exchange reactions o transport inhibitors in rat-liver mitochondria.


The generation of "spikes" by lipo-collagen membranes.


Reconstitution of membranes by recombining proteins and lipids derived from erythrocyte stroma.


Myelin structure and retention of cholesterol in frog sciatic nerve embedded in a resorcinol-formaldehyde resin.


Erythrocyte membrane interactions with menadione and the mechanism of menadione-induced hemolysis.


Acetylcholinesterase and acetylcholine proteolipid receptor: two different components of electroplax membranes.


About the changes of internal ionic concentration in the isolated electroplax during chemical excitation.


Membrane potentials across the bovine lens capsule in vitro.


Absorption of aliphatic hydrocarbons by rats.


The isolation and properties of a beta-alanine permeaseless mutant of Pseudomonas fluorescens.


The effects of high hydrostatic pressure on the permeability characteristics of the isolated frog skin.


Active Na plus and Cl minus transport by the isolation chick chorioallantoic membrane.


Structural effects in the action of antibiotics on the ion permeability of lipid bilayers. 3. Gramicidins "A" and "S", and lipid specificity.


Lithium-stimulated sodium efflux in frog skeletal muscle.


On the permeability of the pancreatic duct membrane.


The large-scale preparation of unsaturated phosphatidyl cholines from egg yolk.


Uptake of alpha-aminoisobutyric acid by cultured human fibroblasts.


Sodium-dependent binding of L-histidine to a fraction of mucosal brush borders from hamster jejunum.


Amino acid absorption in the mammalian colon.


Asymmetrical response of oxyntic cells to direct current in nonstimulated frog gastric mucosa.


Chloride and sodium permeabilities of human red cells.


Inhibition of free fatty acid oxidation by acetoacetate in normal dogs.


The rate of formation and disapearance of microaneurysms i diabetic retinopathy.


Comparison of the absorption of a polar lipid, oleic acid, ad a non-polar lipid, alpha-tocopherol from mixed micellar solutions and emulsions.


The effect of 5-fluorouracil on cells and regenerating protoplsts of Saccharoyces cerevisiae.


Lipase activity in the fat cake and aqueous phase of adipose tissue homogenate of fed, fasted and fasted-refed rats.


Bikaverin, an antibiotic from ibberella fujikoi, effective against Leishmania brasiliensis.


Adolescence, identity, and foster family care.


Foster family services for mentally retarded children.


Drug use among the young: as teenagers see it.


Changing prospects for children with hemophilia.


Effect of androgens on histochemical fibre type. Differentiation in the temporal muscle of the guinea pig.


Histochemical demonstration of 5-hydroxytryptamine in poison glands of amphibian skin.


The effect of polyvinyl alcohol and polyvinyl pyrrolidone on diffusion artifacts in lactate dehydrogenase histochemistry.


Height, weight, height velocity and weight velocity of Bengali Hindu children from birth to 18 months.


A semi-longitudinal study on physical growth of primary school children in Delhi.


Longitudinal growth pattern of children during pre-school age and its relationship with different socio-economic classes.


Birth weight and its relation with certain maternal factors.


Asymptomatic bacteriuria in infants and children.


Diaphragmatic hernia and eventration.

Diaphragmatic hernia and eventration.


Kleeblattschadel deformity syndrome. Report of a case.


Growth and development.

Growth and development.


Reappraisal: classification and nomenclature of newborn babies.


Control of algae in Alexandria water treatment plant.


Wound sepsis and the use of central sterile supply department in a district general hospital.


Toxicity of certain organophosphorus insecticides to Musca vincina. (Diptera: Muscidae).


Antibodies to arboviruses in rodent sera.


A cross-cultural study on the strength of the Müller-Lyer illusion as a function of attentional factors.


Racial differences in reactive versus self-paced sports activities.


Conforming behavior of black and white children.


Social norms and authoritarianism: a Turkish-American comparison.


Field dependence and prior reinforcement as determinants of social interaction in judgment.


Conformity, anticonformity, and independence: their dimensionality and generality.


Effects of experimentally aroused feelings of undistinctiveness upon valuation of scarce and novel experiences.


Effects of conceptual structure on information preference under sensory-deprivation conditions.


Effects of initial level of response competition and frequency of exposure on liking and exploratory behavior.


Response competition as a mediating factor in the frequency-affect relationship.


Generic services for the mentally retarded and their families.


Reflections on recent mental retardation development in Nebraska. I. A new plan.


A survey of public relations practice in public and private residential facilities for the mentally rearded.


A thirty-day residential training program for retarded children.


Analysis of a case of mutagen specificity in Neurospora crassa. 3. Fractionated treatment with diepoxybutane (DEB).


An explanation of fine structure map expansion in terms of excision repair.


Morphogenesis of the tail fiber of bacteriophage T4. II. Isolation and characterization of a component (the genes 35-36-37-38 directing half fiber).


The variation in biochemical reactivity off rough and smooth variants of mycobacteria.


Dissociation in M. avium.

Dissociation in M. avium.


Standard values of some important blood constituents, particularly serum electrolytes, in infancy in Jakarta.


Genetic interaction in mycobacterial host-phage system. The effect of lysogeny on the phage.


"Presumable" congenital rubella syndrome.


Mycobacterial variations as influenced by phage and other genomic factors.


Host-cell determined variations in mycobacteriophages.


Symptoms and treatment of ankylostomiasis in children.


Paroxysmal tachycardia in infancy and childhood.


Social and clinical aspects of epilepsy in Indonesia.


Infectious mycobacteriophage nucleic acids.


Temperature adaptations and biochemical activities of group 3 mycobacteria.


[Clinical problems of mycobacterial variability].


Pigment variations in photochromogenic mycobacteria with special reference to M. vaccae.


Variability of the pigmentation of mycobacteria by the composition of medium.


Multicentric reticulohistiocytosis (lipoid dermato-arthritis): a clinical conundrum.


Indigenous Malay psychotherapy.

Indigenous Malay psychotherapy.


Haemophilia in Nigeria.

Haemophilia in Nigeria.


The problem of epilepsy in Ethiopia.

The problem of epilepsy in Ethiopia.


Urinary lithiasis in Iran. A retrospective study based on 2,114 operations.


Serotypes in, and clinical notes on, leptospirosis in a plantation area of Sumatra.


Self poisoning by drugs. A survey of admissions in Nigeria.


Microfilaria bancrofti and Microfilaria volvulus in hydrocele fluid and tissue sections. Morphology and differential diagnosis.


Influenza A2-HongKong-68 virus in Uganda.


Seasonal variations of natural leptomonad infection in sandflies of rodent burrows.


The effect of antimalaria spraying on the transmission of zoonotic cutaneous leishmaniasis.


Biological false positive VDRL test in malaria.


Cysts of the spleen. Report of two cases.


A seroepidemiologic study of malaria in the Republic of the Philippines by the indirect hemagglutination test.


The chemotherapy of rodent malaria. XII. Substituted tetrahydrofurans, a new chemical family of antimalarials. The action of 2-(p-chlorophenyl)-2-(4-piperidyl)-tetrahydrofuran against Plasmodium berghei and Plasmodium chabaudi.


The formation of unsaturated bile acids by intestinal bacteria.


Clinical experiences with antimonyl-dimethylcysteino-tartrate (NAP) in a rural population infected with Schistosoma mansoni.


Immunization of mice with components of Pasteurella multocida. Log-phase cells of Pasteurella multocida strain P-1059 were used to prepare isolated culture filtrate, cell wall, and cytoplasmic components. Culture filtrate was further separated by column chromatography. A portion of cytoplasm and culture filtrate was conjugated to ferritin by means of metaxylylene diisocyanate. Cell walls induced more protection in mice than the conjugated or unconjugated cytoplasm or culture filtrate. The cell walls caused edema and erythema when given intradermally in rabbits, whereas cytoplasm and culture filtrate produced dermal necrosis. The first of four chromatographically separated fractions of culture filtrate was possibly more immunogenic in mice than cell walls. This fraction was less reactive intradermally in rabbits than cell walls but more reactive than the other fractions.


Wegener's granulomatosis.

Wegener's granulomatosis.


Intra-abdominal vasectomy in bladder neck surgery.


Experiences with dialysis at the General Hospital, Kuala Lumpur.


The jet set.

The jet set.


Mechanisms in pernicious anaemia.

Mechanisms in pernicious anaemia.


Cancer report.

Cancer report.


Clear-cell acanthoma.

Clear-cell acanthoma.


Control of oxygen therapy.

Control of oxygen therapy.


Curiosa et exotica.

Curiosa et exotica.


Skin collagen and thickness in women with hirsuties. Total skin collagen is greatly increased in women with hirsuties. This is presumably due to androgen, whether locally produced or circulating.


Restless legs syndrome, with particular reference to its occurrence after gastric surgery. There is a higher incidence of restless legs syndrome (Ekbom's syndrome) in patients after gastric surgery (11.3%) and with diabetes mellitus (17.0%) and uraemia (17.3%) than in patients who have been diagnosed as having a psychonoeurosis (4.0%) and in controls (2.0%). Three patients with malabsorption syndrome complained of restless legs, but these patients had abnormal neurological signs. The incidence after gastric surgery and in diabetes mellitus and uraemia remained high even when patients with any abnormal neurological signs were excluded.


Cyanide self-poisoning.

Cyanide self-poisoning. Four cases of cyanide self-poisoning were admitted to one hospital over a period of two years. Two of the patients died. The diagnosis in the unconscious patient may be suggested by the finding of bradycardia and the absence of cyanosis (despite inadequate ventilation). The diagnosis can be confirmed in 5 to 10 minutes by a simple test on gastric aspirate, performed by the casualty officer. Cardiac pacing was used in two patients and may have a place in the supportive management of severe cases.


Dipeptide absorption in cystinuria.

Dipeptide absorption in cystinuria. Absorption of a dipeptide and its constituent amino-acids has been studied by a perfusion technique in a patient with cystinuria and in a normal subject. Though the cystinuric patient was unable to absorb the dibasic amino-acid lysine in its free form, the dipeptide glycyl-L-lysine was well absorbed. Both free lysine and glycyl-L-lysine were well absorbed in the normal subject.This finding suggests that the reason that clinical malnutrition does not occur in cystinuria, despite defective intestinal absorption and heavy renal loss of dibasic amino-acids and cystine, is that these amino-acids can be absorbed in the form of oligopeptides.


Parachlorophenylalanine treatment in carcinoid syndrome.


Childhood enuresis.

Childhood enuresis.


Democratic direction.

Democratic direction.


Restless legs syndrome in chronic pulmonary disease. Eight consecutive patients referred for neurological opinion because of very severe "restless legs" all suffered from chronic pulmonary disease. It was considered that the restless legs syndrome was not a metabolic consequence of respiratory failure but a nervous manifestation of their invalidism.


Ban on amphetamines and barbiturates.

Ban on amphetamines and barbiturates.


Amphetamines outmoded.

Amphetamines outmoded.


Hyperpyrexia after anaesthesia.

Hyperpyrexia after anaesthesia.


Fibrosing alveolitis and renal tubular acidosis.


Coagulation failure in pregnancy.

Coagulation failure in pregnancy.


Calcium metabolism in patients with epilepsy.


Alcoholism and industrial absenteeism.

Alcoholism and industrial absenteeism.


Immunization schedules.

Immunization schedules.


Respiratory variations of blood pressure in the ox (Bos taurus) during panting.


Metabolism of drugs. LXIX. Studies on the urinary metabolites of morphine in several mammlian species.


The effect of polytetrafluoroethylene (Fluon) on the characteristics of compressed tablets.


Evaluation of the dissolution rate of drugs from solid pharmaceutical forms.


Metabolism of uridine nucleotides. II. Uridine nucleotides in liver and heart tissues.


Action of antibiotics on the respiratory tract. 3. Chloramphenicol.


Nuclear magnetic resonance studies on selectively deuterated staphylococcal nuclease.


Benzyl and p-nitrobenzyl monoesters of N-t-butyloxycarbonyl-L-glutamic acid and N-t-butyloxycarbonyl-L-aspartic acid.


Photochemical inactivation of L-kynurenine 3-hydroxylase (EC 1.14.1.2) preparations from rat liver.


Molecular weights of pig liver cell membrane proteins.


Interaction of alcohols with lysozyme. I. Studies on circular dichroism.


Interaction of alcohols with lysozyme. II. Studies on difference absorption spectra.


Incorporation of radioactive iron into cytochrome b5 and cytochrome P-450 of liver microsomes.


Structure and function of chloroplast proteins. XI. Dissociation of spinach leaf ribulose-1,5-diphosphate carboxylase by urea.


Changes in turnover rates of some enzymes involved in nitrogen metabolism in the rat liver after administration of carbon tetrachloride.


Heat balance of S-peptide-S-protein binding in ribonuclease S.


Partial structure of a glycopeptide from Taka-amylase A.


Homoserine dehydrogenase genetically desensitized to the feedback inhibition in Brevibacterium flavum.


Preferential binding of RNA polymerase to the thymidylic acid-rich fragments obtained from bacteriophage fl DNA.


The effect of neutral salts on gelatin and peptides containing L-proline.


Binding of 3'-guanylic acid and related compounds to ribonuclease T1--gel filtration studies.


Isoenzymes of glycogen phosphorylase in pig brain.


Experiments on chromosome elimination in the gall midge, Mayetiola destructor.


Early actions of cadmium in the rat and domestic fowl testis. V. Inhibition of carbonic anhydrase.


Immunological studies on chicken gonadotrophins.


Surgical treatment of male infertility.

Surgical treatment of male infertility.


Deducing the consequences of evolution: a mathematical model.


Analysing sequences of behavioural events.


Effect of tri-hydroxymethyl-aminomethane (Tris) on insulin secretion in vitro.


The hemiblocks: diagnostic criteria and clinical significance.


The incompatibility relationships between geographic races of Podospora anserina. IV. Biochemical aspects of the heterogenic incompatibility.


Use of fatty acids for the control of Papilio demoleus L.


Protein-bound calcium in tumors.

Protein-bound calcium in tumors.


Virus-like particles in the hamster melanoma A Mel 3 of fortner.


Synaptonemal complexes in haploid Petunia and Antirrhinum sp.


Physical data on the essential oils of five compositae plants.


Human aggression.

Human aggression.


Maternal eating habits and fetal motility.


Minute pulmonary arteriovenous fistulas demonstrated by magnification pulmonary angiography. Case report.


The determination of spleen mass from radionuclide images.


Residential care for the mentally subnormal.


Repeat lymphangiography in Hodgkin's disease.


The angiographic appearance of hydatid disease.


Conjoint family therapy.

Conjoint family therapy.


Battered babies.

Battered babies.


Acute pulmonary oedema from sensitivity to beta-sympathetic blockade.


Recognition of experience in general practice.


Bezoars occurring in the gastric remnant after gastrectomy.


The management of white certified schizophrenic patients in the community of the Witwatersrand.


A simple and reliable method of exteriorizing a functioning kidney for experimental purposes.


Precocious sexual development following tuberculous meningitis: a case report.


A follow-up study of learning through colour.


Drug names on pill boxes.

Drug names on pill boxes.


The case against smoking.

The case against smoking.


The working mother. The effect upon home and family.


Diet-induced hypercholesterolemia in the chinchila and rabbit.


Complexing of serum pre-beta and beta-lipoproteins and acid mucopolysaccharides.


Leukocyte reserves of newborn infants. I. Observations during exchange transfusions.


The structure and the biological activities of sulfopolyglucans. 2. The effect of sulfoevernan and heparin on lipid metabolism.


Diet and cholesterl metabolism in young and old baboons.


Origin of cholesteryl oleate and other esterified lipids of rabbit atheroma.


A study on the erythropoiesis stimulating effect of the thyroid hormone. I. Erythropoiesis stimulating effect of D- and L-triiodothyronine.


Tissue lactate dehydrogenase isoenzyme patterns in rats fed a hypercholesterolaemic diet.


Electron microscopic study on acid phosphatase of macrophges during the breakdown of erythrocytes in the spleen of the rat.


Cholesterol biosythesis: lack of feedback control in circulating leucocytes.


[Ga-iquid chromatoraphy of akaloids].

[Ga-iquid chromatoraphy of akaloids].


Evidence for the participation of the Golgi apparatus in the intracellular transport of nascent albumin in the liver cell. A comparative biochemical and radioautographic in vivo study was performed to identify the site of synthesis and route of migration of albumin in the parenchymal liver cell after labeling with leucine-(14)C or leucine-(3)H via the portal vein. Free cytoplasmic ribosomes, membrane-bound ribosomes, rough- and smooth-surfaced microsomes, and Golgi membranes were isolated. The purity of the Golgi fraction was examined morphologically and biochemically. After administration of leucine-(14)C, labeled albumin was extracted, and the sequence of transport was followed from one fraction to the other. Approximately 2 min after the intravenous injection, bound ribosomes displayed a maximal rate of leucine-(14)C incorporation into albumin. 4 min later, a peak was reached for rough microsomes. Corresponding maximal activities for smooth microsomes were recorded at 15 min, and for the Golgi apparatus at approximately 20 min. The relative amount of albumin, calculated on a membrane protein basis, was higher in the Golgi fraction than in the microsomes. By radioautography the silver grains were preferentially localized over the rough-surfaced endoplasmic reticulum at the 5 min interval. Apparent activity in the Golgi zone was noted 9 min after the injection; at 15 and 20 min, the majority of the grains were found in this location. Many of the grains associated with the Golgi apparatus were located over Golgi vacuoles containing 300-800 A electron-opaque bodies. It is concluded that albumin is synthesized on bound ribosomes, subsequently is transferred to the cavities of rough-surfaced endoplasmic reticulum, and then undergoes migration to the smooth-surfaced endoplasmic reticulum and the Golgi apparatus. In the latter organelle, albumin can be expected to be segregated together with very low density lipoprotein in vacuoles known to move toward the sinusoidal portion of the cell and release their content to the blood.


Duration of premeiotic deoxyribonucleic acid synthesis and the stages of prophase I in rabbit oocytes. To estimate the duration of oocyte DNA synthesis 36, 3-day-old female rabbits received 3, 6, 9, 12, 15, or 18 injections of tritiated thymidine (thy-(3)H) at hourly intervals. The ovaries, removed at 1, 10, or 20 days after the first injection, were radioautographed. Counts made of the number of silver grains associated with oocyte nuclei in meiotic Prophase I indicate that the duration of DNA synthesis is between 9 and 12 hr. To determine the length of the stages of meiotic Prophase I, a group of 2-3-day-old rabbits was given a single sub-cutaneous injection of thy-(3)H, and the ovaries were removed at hourly and/or daily intervals after treatment. The minimum duration of leptotene was 3 hr and the maximum duration probably was less than 8 hr. The maximum durations of zygotene, pachytene, and diplotene were estimated to be 44, 216, and 96 hr, respectively. The interval from the end of oogonial DNA synthesis to the beginning ofpremeiotic DNA synthesis (G(2) + Mitosis + G(1)) appeared to be less than 6 hr.


The effects of high hydrostatic pressure on the microtubules of Tetrahymena pyriformis. Exposure of Tetrahymena pyriformis to 7,500 or 10,000 psi of hydrostatic pressure for 2, 5, or 10 min intervals results in a change in cell shape and ciliary activity. Shape changes occur concurrently with a degradation of longitudinal microtubules in a posterior to anterior direction. High pressure also causes a disruption of ciliary activity. Fine structural analysis reveals a breakdown (presumably microtubule depolymerization) of the central ciliary microtubules. The depolymerization begins at the junction of the central ciliary microtubules with the axosome and progresses distally along the ciliary shaft for a distance of about 0.5 micro.


Effects of accuulated tissue cholesterol on bile acid etabolism in hypophysectomized rats and hamsters.


Quantitative aspects of transmitter release. The opener-stretcher motor neuron in crayfish makes 50 endings upon each of 1200 muscle fibers. We have calculated the quantal content of junctional potentials produced by individual terminals and by the whole cell at various physiological frequencies. The results show that when the motor neuron is active at 20 impulses/second, it releases 50 quanta/impulse per muscle fiber, or a total of 4.5 x 10(9) quanta/hr. These figures are similar to those for vertebrate muscles per fiber, but larger for the entire neuron because the opener motor unit is so large. On the basis that the quanta correspond to synaptic vesicles each containing 10(3)-10(4) molecules of transmitter, the release rate must be around 10(-11) mole/hr. This value is within an order of magnitude of the release figures obtained for mammalian neurons by collecting transmitter in perfusates, but it is far lower than the value reported for a crustacean inhibitory neuron. If the membrane materials surrounding each vesicle were lost in the release process, the replacement synthesis would involve 24 mm(2) of membrane/hr. We conclude that the metabolic load in terms of transmitter synthesis is probably sustainable, but that the release mechanism must operate in such a way that vesicle membrane materials are neither lost nor incorporated into the terminal membrane.


The chemical nature of keratohyalin granules of the epidermis. Keratohyalin granules were isolated in the native form from the epidermis of newborn rats by the use of citric acid and a detergent. The isolated granules revealed a fine granular substructure in the electron microscope similar to that seen in situ. Analyses of amino acids by automated column-chromatography showed that proline and cystine are present in large proportions whereas histidine is present in a small amount. Accordingly, it was concluded that keratohyalin represents a sulfur-rich amorphous precursor of the horny cell content, rather than a sulfur-poor side product of the keratinization process, or a unique histidine-rich protein as proposed by in situ histochemical and radioautographic studies.


Studies on nuclear structure and function in Tetrahymena pyriformis. II. Isolation of macro- and micronuclei. This report describes a rapid, efficient method for isolating macronuclei from Tetrahymena. The macronuclear fraction contains only small amounts of micronuclear material and little detectable whole cell or cytoplasmic contamination. A method is also described for preparing a "micronuclear fraction" which contains 20-40 micronuclei for every macronucleus present. Electron microscope observations indicate that the ultrastructure of the nuclei in the macronuclear fraction closely resembles that of nuclei in situ. The presence of ribosomes on the outer membrane of micronuclei and of pores in the micronuclear envelope is also described.


Studies on nuclear structure and function in Tetrahymena pyriformis. 3. Comparison of the histones of macro- and micronuclei by quantitative polyacrylamide gel electrophoresis. Histones were extracted from isolated macro- and micronuclear fractions and from nucleohistone fibers which were prepared from the isolated macronuclear fraction. Analysis of these histones by polyacrylamide gel electrophoresis indicated that there are electrophoretic differences between the histones of macro- and micronuclei.


Isolation of rat liver plasma membranes. Use of nucleotide pyrophosphatase and phosphodiesterase I as marker enzymes. Nucleotide pyrophosphatase and phosphodiesterase I of rat liver have been found to be localized primarily in cell particulates highly enriched with respect to the most commonly accepted plasma membrane marker, 5'-nucleotidase, and therefore should themselves be assigned a plasma membrane localization. The observation that plasma membranes sediment in isotonic sucrose with both nuclear and microsomal fractions was exploited to obtain plasma membrane preparations from each fraction. Both preparations are similar in chemical and enzymic composition. Moreover, the preparative method developed in this study appears to give the best combination of yield, purity, and reproducibility available. The question of the possible identity of nucleotide pyrophosphatase and phosphodiesterase I is considered, and evidence is presented suggesting that these activities may be manifestations of the same enzyme.


A cytological study of the relation of the cortical reaction to subsequent events of fertilization in urethane-treated eggs of the sea urchin, Arbacia punctulata. Eggs of the sea urchin, Arbacia punctulata, treated with 3% urethane for 30 sec followed by 0.3% urethane and inseminated are polyspermic and fail to undergo a typical cortical reaction. Upon insemination the vitelline layer of urethane-treated eggs either does not separate or is raised only a short distance from the oolemma. 1-6 min after insemination, almost all of the cortical granules remain intact and are dislodged from the plasmalemma. Later (6 min to the two-cell stage) some cortical granules are released randomly along the surface of the zygote. Not all zygotes show the same degree of cortical granule dehiscence; most of them experience little if any granule release whereas others demonstrate considerably more. The thickness of the hyaline layer appears to be directly related to the number of cortical granules released. Subsequent to pronuclear migration, several male pronuclei become associated with the female pronucleus. Later the male and female pronuclear envelopes contact and the outer and the inner laminae fuse, thereby forming the zygote nucleus. The male pronuclei remaining in the cytoplasm increase in size and progressively migrate to, and fuse with, the zygote nucleus. By 60 min some zygotes appear to contain only one large zygote nucleus which subsequently enters mitosis. Other zygotes possess a number of male pronuclei which remain unfused, and later these pronuclei along with the zygote nucleus undergo mitosis. There does not appear to be a direct relation between the number of cortical granules a zygote possesses and the above mentioned dichotomy.


Kinetoplast deoxyribonucleic acid of the hemoflagellate Trypanosoma lewisi. Cesium chloride centrifugation of DNA extracted from cells of blood strain Trypanosoma lewisi revealed a main band, rho = 1.707, a light satellite, rho = 1.699, and a heavy satellite, rho = 1.721. Culture strain T. lewisi DNA comprised only a main band, rho = 1.711, and a light satellite, rho = 1.699. DNA isolated from DNase-treated kinetoplast fractions of both the blood and culture strains consisted of only the light satellite DNA. Electron microscope examination of rotary shadowed preparations of lysates revealed that DNA from kinetoplast fractions was mainly in the form of single 0.4 micro circular molecules and large masses of 0.4 micro interlocked circles with which longer, often noncircular molecules were associated. The 0.4 micro circular molecules were mainly in the covalently closed form: they showed a high degree of resistance to thermal denaturation which was lost following sonication; and they banded at a greater density than linear DNA in cesium chloride-ethidium bromide gradients. Interpretation of the large masses of DNA as comprising interlocked covalently closed 0.4 micro circles was supported by the findings that they banded with single circular molecules in cesium chloride-ethidium bromide gradients, and following breakage of some circles by mild sonication, they disappeared and were replaced by molecules made up of low numbers of apparently interlocked 0.4 micro circles. When culture strain cells were grown in the presence of either ethidium bromide or acriflavin, there was a loss of stainable kinetoplast DNA in cytological preparations. There was a parallel loss of light satellite and of circular molecules from DNA extracted from these cells.


Metabolism of bilirubin by a clonal strain of rat hepatoma cells. These studies demonstrate that the MH(1)C(1) strain of rat hepatoma cells has the ability to take up and conjugate bilirubin and then excrete the conjugated pigment into the culture medium. On incubation with unconjugated bilirubin, the average rate of appearance of conjugated bilirubin in the medium was 4.4 +/- 0.20 microg per mg of cell protein per hour (mean +/- SE). The products formed from bilirubin by MH(1)C(1) cells were chromatographically identical to those found in normal rat bile. Assay of bilirubin UDP glucuronyl transferase activity in homogenates of MH(1)C(1) cells gave a value of 3.3 +/- 0.50 microg of conjugated pigment formed per mg protein per hour, only moderately less than the enzyme activity of liver from normal rats. Rat fibroblasts in culture did not conjugate bilirubin, nor did they contain bilirubin UDP-glucuronyl transferase activity. As in living animals, flavaspidic acid inhibited bilirubin metabolism by MH(1)C(1) cells, suggesting that the mechanism for bilirubin uptake is similar to that of normal liver. In contrast to the findings in animals, however, preincubation of MH(1)C(1) cells with phenobarbital led to only minimal enhancement of pigment conjugation. MH(1)C(1) cells represent the first example of a clonal strain of cells in culture in which many of the pathways of hepatic bilirubin metabolism remain intact. They should, therefore, serve as a useful model for studies of bile pigment metabolism which are not easily performed in the living animal.


A cytological study of the centrifuged whole, half, and quarter eggs of the sea urchin, Arbacia punctulata. While the ooplasmic components of centrifuged eggs of Arbacia punctulata do not stratify in homogeneous layers, we have obtained the following strata beginning with the centripetal end: lipid droplets, pronucleus, clear zone, mitochondria, yolk, and pigment. Whereas mitochondria may be found mingled with yolk bodies, we have never observed lipid droplets nor pigment bodies among any of the other inclusions. The so-called clear zone contains a heterogeneous population of inclusions: annulate lamellae, heavy bodies, Golgi complexes, and rod-containing vacuoles. The peripheral cortical granules of immature (germinal vesicle stage) and of mature eggs are not dislodged from the cortical ooplasm with the centrifugal force utilized. When the eggs are treated with urethane, prior to centrifugation, the cortical granules of mature eggs abandon their peripheral position. Further centrifugation of the initially stratified eggs produces nucleated and nonnucleated halves and the centrifugation of the halves results in quarters. The cytology of the halves and quarters is discussed. The halves and quarters have been activated with either sperm or hypertonic sea water. With the exception of the nucleated halves, we were unable to obtain plutei larvae from the other fractions (red halves and quarters). We believe that the lack of development of the various fragments is a function of the balance of particular inclusions necessary for differentiation.


RNA synthesis in HeLa cells. Pattern in hypertonic medium and its similarity to synthesis during G2-prophase. Interphase HeLa cells manifest a stepwise shutoff of RNA synthesis when the tonicity of the extracellular medium is gradually increased. Synthesis of heterogeneous nuclear RNA is most sensitive and is selectively inhibited at 1.5 times isotonicity (450 milliosmols/liter), while 45S ribosomal RNA synthesis is not affected significantly below 2.0 times isotonicity. Transfer RNA synthesis is least sensitive to increased osmolarity and is not completely inhibited until the electrolyte concentration of the medium is elevated to 2.8 times isotonicity. Although the transcription and methylation of 45S ribosomal precursor is unaffected at 1.5 times isotonicity, there is pronounced impairment of its processing into 32S and 18S RNA. Using a refined cell synchronization technique, we have been able to compare these effects of hypertonicity with the shutoff of RNA synthesis which occurs during the G(2)-prophase interval of the cell division cycle. In this case, as with random cells in hypertonic medium, a selective inhibition of heterogeneous nuclear RNA synthesis and slowed processing of 45S ribosomal RNA were found, whereas synthesis of 45S and transfer RNA continued unabated throughout G(2)-prophase. While it is known that RNA synthesis essentially ceases during metaphase, we have noted that transfer RNA synthesis continues in metaphase at 10-15% of the interphase rate, which is of particular interest in view of the relative resistance of this species to hypertonicity. The close correlation between the patterns of cessation of RNA synthesis at mitosis and during exposure to hypertonic medium supports our earlier contention that alteration of intracellular electrolyte levels provides a useful model for studying the mechanism of mitosis.


Growth and differentiation of cytoplasmic membranes in the course of lipoprotein granule synthesis in the hepatic cell. I. Elaboration of elements of the Golgi complex. The synthesis of "very low" density lipoprotein in liver cells is characterized by the fact that the synthesized products, mostly triglycerides, are processed in the form of discrete, size-limited granules or globules, about 400 A in diameter. The present investigation has been made possible in part by the use of a fixative (OsO(4) in bidistilled H(2)O at pH 6.0, in the absence of electrolytes) particularly effective in preserving cytoplasmic membranes and lipids, and giving them high stainability and differential contrast. Under these technical conditions, the lipoprotein granules retain their morphology and high density to electrons practically unaltered, and may serve as tracers in determining their route of transport from the sites of synthesis, starting at the rough-smooth ER junctions, to the lumen of Golgi concentrating vesicles. From the observations, it may be deduced that, along with lipoprotein granule synthesis and transport, there are also production and transfer of new membranes in the form of tubular extensions of smooth ER network which, by progressive fusion and coalescence, participate in the elaboration of fenestrated plates and solid Golgi sacs. In contradistinction to the entire process of liver lipoprotein granule synthesis, transport, and segregation, as reported in the present paper, appears to constitute a developmental sequence which includes the following communicating compartments, in consecutive order: cisternae of rough ER where proteins and possibly phospholipids are synthesized, smooth ER network where triglycerides are synthesized and transported in the form of dense granules, fusion of smooth ER tubular extensions into Golgi fenestrated plates, and further coalescence into solid Golgi sacs, ending in the segregation of the granules in appended concentrating vesicles, or detached "secretory vesicles." It seems that it is this progressive evolution in growth and configuration of membranes which is reflected in the so called polarity, from forming to mature faces, of the Golgi apparatus.


Ultrastructural studies on red blood cells from thyroxin-treated Rana catesbeiana tadpoles.


The macronuclear envelope of Tetrahymena pyriformis GL in different physiological states. 3. Appearance of freeze-etched nuclear pore complexes.


Flagellar elongation and shortening in chlamydomonas. II. Re-utilization of flagellar proteins.


Definition of the extracellular space in secreting and nonsecreting oxyntic cells.


Contraction bands at short sarcomere length in chick muscle.


Observed differences in CO2 requirements between mammalian and salmonid fish cell lines.


A study of aspects of heterokaryosis in Aspergillus nidulans.


Shatter-resistant lenses.

Shatter-resistant lenses.


Diabetic retinopathy therapy.

Diabetic retinopathy therapy.


A successful compaign to prevent blindness.


Can the food and nutrition problems of Indonesia be solved?


Current thoughts on contact lenses.

Current thoughts on contact lenses.


Eye problems encountered by the nonophthalmologist.


Vision organizations in the UITED States.


Bullous emphysematous lesions in a tuberculous child.


Studies on experimental bladder calculi. I. Preliminary report on attempt to produce bladder calculi in monkeys.


Clinical and theoretical models in radiotherapy.


Outline of a theory of comparative biology.


Composition of somatic antigens of Rhizobium trifolii and Rhizobium leguminosarum.


Spatial summations of vasomotor reflexes.


Effect of Tris-buffer infused into the renal artery of dogs.


Lipid composition of tonic and tetanic muscles.


Influence of cortisone on heart rate during fear extinction in the rat.


Effect on thyroid function of long-term oestrogen treatment at high dose level in the rat.


Effect of hippocampal stimulation on the establishment of conditioned fear response in the rat. An electrophysiological, behavioural and endocrine study.


Effects of small intestinal resection or exclusion in haemorrhagic shock.


Relationship between chemical structure and pharmacological activity in a series of central muscle relaxant oxadiazole derivatives.


A compound with a strong and specific central anticholinergic activity, 2-dimethylamino-9-benzilyloxy-bicyclo (3,3,1) nonane.


Particulate contamination in vials of sterile dry solids.


A documented, cross-indexed manual to human drug interactions.


Mechanisms of drug interaction in the pharmacokinetic phase of drug activity.


The status of unit dose dispensing in United States hospitals: 1969.


Manual patient drug profiles as part of a drug distribution system.


A note on Shellhaas and Nihira's "factor analysis of reasons retardates are referred to an institution".


The development of head banging in a young rhesus monkey.


Classical and atypical phenylketonuria among Egyptians: study of 10 families.


Frequency vs. magnitude of GSR in comparisons of retarded and nonretarded groups.


Agglutinating factor eluted from the erythrocytes of swine with rheumatoid arthritis.


Psychology training in emergency services.


Interaction between electron transport components in chloroplasts.


On the enzymatic conversion of 14C-labeled chlorophyll a to 14C-labeled chlorophyll b.


Functional bacteriochlorophyll-protein complexes from chromatophores of Rhodopseudomonas spheroides strain R-26.


Characteristics of a lipid-rich NADH dehydrogenase-containing particulate fraction obtained from Micrococcus lysodeikticus membranes.


Fragmentation by detergents of the respiratory chain of Micrococcus lysodeikticus membranes.


Isolation of NADH-cytochrome b5 oxidoreductase from rat liver microsomes.


Effect of antimycin of the potato mitochondrial cytochrome b system.


High-energy forms of cytochrome b. I. The effectof ATP and antimycin on cytochrome b in phosphorylating sub-mitochondrial particles.


High-energy forms of cytochrome b. II. The effect of ATP and antimycin on cytochrome b in intact mitochondria.


Energy transfer in the glutamate dehydrogenase-NADH binary complex and its relation to the binding of cofactor.


Energy conservation associated with cyanide-insensitive respiration in plant mitochondria.


Substrate supply for nuclear oxidative phosphorylation.


Cellular energy metabolism during fetal development. 3. Deficient acetyl-CoA synthetase, acetylcarnitine transferase and oxidation of acetate in the fetal bovine heart.


A rapid and simple procedure to deplete rat-liver mitochondria of lysosomal activity.


Deficient energy metabolism in streptomycin-dependent Escherichia coli.


Molybdenum associated with NADH dehydrogenase in complex I.


Chorophyll-pheophytin interactions.

Chorophyll-pheophytin interactions.


The effect of adenine nucleotides and pH on the inhibition of oxidative phosphorylation by bongkrekic acid.


Chlorophyll a-containing liposomes.

Chlorophyll a-containing liposomes.


An exploratory study of teachers' perceptions of the process of planning courses.


The effects of creativity and intelligence on teacher ratings.


Intellectual style and achievement of Arts and Science undergraduates.


A unifying concept of aging, senescence (cancer, blood vessel disease, diabetes mellitus and altered cell-immunocyte interaction) and death in man.


Estimation o latent iron binding capacity using Fe.


The cytochemical demonstration and localisation of succinic dehydrogenase in Candida species.


Stab wounds of the abdomen.

Stab wounds of the abdomen.


Effect of levorphanol on putrescine transport in Escherichia coli.


Nuclear magnetic resonance studies on acetylcholinesterase. The use of atropine and eserine to probe binding sites.


Relationship between structure, conformation, and antischistosomal activity of nitroheterocyclic compounds.


Reduced nicotinamide adenine dinucleotide phosphate-dependent binding of competitive inhibitors to dihydrofolate reductase.


Enzymatic studies relating to the mode of action of 5-mercapto-2'-deoxyuridine.


Role of phospholipids in the hepatic microsomal drug-metabolizing system.


Competition for polymeric binding sites between acridine and triphenylmethane dyes.


Induction of drug metabolism. V. Independent formation of cytochromes P-450 and P1-450 in rats treated with phenobarbital and 3-methylcholanthrene simultaneously.


Determination of the mutagenic activity to bacteriophage T4 of carcinogenic and noncarcinogenic compounds.


Catechol O-methyltransferase. 3. M- and p-O-methylation of catecholamines and their metabolites.


Mutagenic effects of near ultraviolet and visible radiant energy on continuous cultures of escherichia coli.


The technique of thermal measurements in excitable tissues.


Microcalorimeters.

Microcalorimeters.


Nematodes from the banks of still and running waters. IX. Two new genera belonging to subfamily Diplogasterinae micoletzky from India.


Synthesis of 17-alpha-hydroxycholesterol.


The effect of immunity on the vascularization of skin allografts.


Active inhibition of the allograft response in H-2-incompatible mice.


HL-A antigen studies with leukocyte cell lines.


An assay for antibodies to histocompatibility antigens based on inhibition of radioiodine-labeled antibody binding.


Early renal transplant failure associated with subliminal sensitization.


Liver-induced immunosuppression of allograft immunity in urodele amphibians.


Reactions to skin allografts in the horn shark, Heterodontis francisci.


Methylprednisolone therapy and allograft rejection. Comparison of daily and alternate day administration.


Specificity of cytotoxic antibodies. Assay for anti-I, anti-P + P1, and heterophile antibody activity.


Isolation and transplantation of 10-20 mouse lymphoma cells in a semisolid medium.


Shape and structure of pseudocrystals in the human vitreous.


Histochemical study of mucopolysaccharides and the deposition of mineral salts in postembryonic chondral ossification.


Polarization-optical study of the ultrastructure of cell nuclei in tissue cultures.


Histochemistry of avian spermatogenesis.


Tumours induced by diphenylhydantoin.

Tumours induced by diphenylhydantoin.


Formation of Russell bodies in rheumatoid arthritis.


Morphological changes in the course of experimental salmonellosis in rabbits.


Fluorescent histochemical examination of connective tissue. IV. Application of flavophosphine in the histochemistry of acid mucopolysaccharides.


Value of neurological and angiographic signs as indicators of the ruptured aneurysm in patients with multiple intracranial aneurysms.


Comparison of the inotropic response to glucagon, ouabain and noradrenaline. 1. The inotropic activity of glucagon was compared with catecholamines and cardiac glycosides by in vitro procedures which were able to differentiate between the activities of the latter two groups.2. The frequency-force curve for glucagon resembled that of noradrenaline at low stimulation frequencies (1 and 2/min) and that of ouabain at more rapid frequencies of stimulation.3. Noradrenaline and adrenaline increased the amplitude of contraction of cat papillary muscles and markedly shortened the time to reach peak tension. Ouabain and glucagon increased tension without any change in the time to peak tension.4. Noradrenaline caused a rapid onset and rate of rise of contraction of cat aortic strips, whereas the response to ouabain was slow in onset and rate of development. Glucagon had no effect on this preparation, even at high concentrations.5. Manganese ions caused a shift of the dose-response curve to ouabain and glucagon, but not to noradrenaline or calcium. In 0.5 mM Ca media, the response to ouabain was abolished and the curve to noradrenaline shifted.6. When glucagon was added to an atrial preparation, the time to the initial increase in tension and the time to maximal tension was intermediate between that necessary for noradrenaline and that necessary for cardiac glycosides.7. Propranolol blocked the inotropic response to noradrenaline, but not to either ouabain or glucagon.8. A relative measure of contraction-dependency was described. Cardiac glycosides exhibited a greater degree of contraction-dependency than either noradrenaline or glucagon.9. Adrenaline elevated the depressed plateau of the action potential from calf and sheep Purkinje fibres, but ouabain and glucagon were without effect.10. Electrophysiological measurements demonstrated that moderate concentrations of glucagon exerted only a small effect in prolonging atrial and ventricular action potentials.11. Several pharmacological blocking drugs and other inotropic agents did not potentiate or block the inotropic response to glucagon. Reserpine pretreatment increased the response to glucagon.12. It was concluded that glucagon has its own spectrum of inotropic activity and does not completely mimic the effects of either ouabain or noradrenaline.