Cytolytic effect of 6-hydroxydopamine on neuroblastoma cells.


In vivo interaction of urethan with nucleic acids and proteins.


Effect of enzyme induction on the metabolism and tissue distribution of benzo(alpha)pyrene.


Stimulatory effect of benzo(alpha)pyrene and phenobarbital pretreatment on the biliary excretion of benzo(alpha)pyrene metabolites in the rat.


Inhibitory effects of D-glucosamine on the growth of Walker 256 carcinosarcoma and on protein, RNA, and DNA synthesis.


A ganglioneuroma in the adrenal medulla of a rat bearing a preoptic-anterior hypothalamic lesion.


Antigen-specific immunity in recipients of leukocyte transfusions from immune donors.


Irreversible inhibition of dehalogenation of 5-iodouracil by 5-diazouracil and reversible inhibition by 5-cyanouracil.


The oncogenicity of two 1,1-diaryl-2-propynyl N-cycloalkylcarbamates.


Immunological and pathological manifestations of murine sarcoma virus (Moloney) infections.


Ultrastructure of beta-cells during the dynamic response to glucose and tolbutamide in vitro.


The metabolism of ketones, triglyceride and monoglyceride in livers of obese hyperglycaemic mice.


The response to intravenous glucose infusion in normal and diabetic subjects.


The role of the portal circulation in glucose and fructose tolerance.


Continuous monitoring of blood sugar in brittle diabetics.


Effect of diet on blood and tissue lipid levels in aged male rats.


Age changes in the subunit composition of rat tail tendon collagen extracted at 65 degrees C in water and a 2 degrees C in acid.


Electron microscopic studies of the adenohypophyses of aged rats.


Thymus nucleoproteins. Thymus histones in young and adult rats.


The reactivity of isolated small arteries for norepinephrine in essential hypertension.


The influence of diuretics on the intrarenal distribution of 45Ca2.


Renal effects and side effects of diuretics.


Fetal heart monitoring.

Fetal heart monitoring.


Fees, income, and methods of payment.

Fees, income, and methods of payment.


Changes in body composition and metabolism induced by sucrose in the rat.


Preparation of a purified, scorbutogenic diet for guinea pigs, with determination of vitamin C content of individual feed components.


Nutrition and the ischemic heart disease mortality rates in 33 countries.


Non-traumatic rupture of a coronary artery. Report of a case.


Haemodynamic results of aortic valve replacement with the Kay-Shiley disc valve.


Revascularizing effect of diaphragm graft on ischaemic myocardium. An experimental study in the dog.


Mechanically induced ventricular systoles during external massage and thumping of the chest.


Ultrasound used for the registration of arterial pulse curves.


Flow pattern in central and peripheral human veins. A pilot study.


Postpneumonectomy empyema in pulmonary carcinoma patients.


Oesophageal hiatus hernia. Follow-up studies after surgical correction.


Graduates of British and Irish medical schools in United States.


Class characteristics of supporters and rejectors of basic health measures.


A challenge to youths: summer 1968.

A challenge to youths: summer 1968.


Medical education. The training of psychiatric practitioners. A quantitative study of therapeutic performances by residents in psychiatry.


Herniation of the heart.

Herniation of the heart.


Surgery of ventricular septal defect and pulmonary vascular resistance.


New pathological findings in emphysema of childhood. 1. Polyalveolar lobe with emphysema.


Disseminated aspergillosis.

Disseminated aspergillosis.


Early detection of mediastinal spread of pulmonary carcinoma by mediastinoscopy.


Circulatory effects of potassium, glucose and insulin following open-heart surgery.


Relationship between posterior pharyngeal pouch and hiatus hernia.


Aethritis and arthralgia in infection with Mycoplasma pneumoniae.


Effect of tolazoline hydrochloride on sputum viscosity in cystic fibrosis.


Lung manifestations in leptospirosis.

Lung manifestations in leptospirosis.


Foetal intensive care.

Foetal intensive care.


The ultrastructure of cardiac myxoma.

The ultrastructure of cardiac myxoma.


A case of chronic paraffin pneumonitis.

A case of chronic paraffin pneumonitis.


Foetal intensive care during pregnancy.

Foetal intensive care during pregnancy.


Behavior disorders of the adolescent. Student mental health.


The adolescent heroin addict.

The adolescent heroin addict.


Antibody deficiency syndromes.

Antibody deficiency syndromes.


Immune deficiency states.

Immune deficiency states.


Chronic granulomatous disease of childhood.


Hiatus hernia (surgical aspects).

Hiatus hernia (surgical aspects).


Subarachnoid haemorrhage.

Subarachnoid haemorrhage.


Diagnosis and management of subarachnoid haemorrhage.


Carriage of invalids by air.

Carriage of invalids by air.


Clinical aspects of calcium metabolism.

Clinical aspects of calcium metabolism.


Clinical aspects of calcium metabolism. Bone diseases.


The function of the thymus.

The function of the thymus.


Radiology of the thymus.

Radiology of the thymus.


The efficiency of a paste formulation of hexachlorophene against Fasciola hepatica in sheep.


Veterinary surgeons and the E.E.C.

Veterinary surgeons and the E.E.C.


The profession in the Netherlands.

The profession in the Netherlands.


Acute leucemia in a patient with juvenile rheumatoid arthritis displaying cystic osseous lesions.


Possible "orf" (contagious pustular dermatitis, contagious ecthyma of sheep) infection in the dog.


Scimitar syndrome.

Scimitar syndrome.


An unusual case of cyst hydatid.

An unusual case of cyst hydatid.


The accumulation of mercury in chickens following the prolonged administration of low levels of an inorganic mercurial.


The complement fixation test as an indicator of Bedsonia respiratory infection in cattle.


Spontaneous peritonitis in cirrhosis of the liver in a child.


Henbane (Hyoscyamus niger) poisonings in the vicinity of Erzurum.


The value of nose and throat swab cultures in managing the attacks of asthmatic children.


Cerebro-spinal fluid lactate concentration in neurologically normal and abnormal children.


Changes in the muscle and skin blood flow following lower leg fracture in man.


Properties of acetohydroxy acid synthetase in Streptomyces rimosus.


[Regulatory action of chlorpromazine on the activity of some dehydrogenases].


The nesting behaviour of hens with ovarian transplants.


Comparative effects of glycopyrrolate, atropine sulfate and propantheline bromide on canine parietal cell ultrastructure.


The effects of halothane on respiratory and cardiovascular responses to hypoxia in dogs: a dose-response study.


Concerning the organization of thrombi.

Concerning the organization of thrombi.


Concentration of Rift Valley fever and Chikungunya viruses by precipitation. Simple and efficient methods for concentrating Rift Valley fever (RVF) virus and chikungunya (CHIK) virus are described. Ammonium sulfate, potassium sulfate, or alcohol was used as a precipitating agent and the precipitate was resuspended to volumes suitable for further processing and purification. The methods permitted concentration of live RVF virus and CHIK virus about 100-fold with negligible losses of virus. RVF virus retained a high level of infectivity with potassium aluminum sulfate and alcohol, but CHIK virus retained a higher infectivity level with ammonium sulfate than with potassium aluminum sulfate. The data indicate that serum plays an important role in the concentration of both viruses, at least when the sulfate methods are used.


The President's address.

The President's address.


Malignant melanoma of the iris in children. A report of a case in a 9-year-old girl.


Pros and cons of departmentalization--a survey of college and university speech pathology and audiology programs.


Inhibition of adenovirus replication by canavanine.


Role of a volatile female sex pheromone in stimulating male courtship behaviour in Drosophila melanogaster.


Studies on the mechanisms of delayed and stimulated delayed fluorescence of chloroplasts.


Conformational differences of immunoglobulin G subclasses.


Mechanisation in clinical chemistry: trends and equipment. 1.


Graphic display for clinician-computer interaction in clinical management.


A body scanner using a matrix system.

A body scanner using a matrix system.


Risk-taking and anxiety among successful and unsuccessful, traditional and progressive agricultural entrepreneurs of Delhi.


Scales for a British personality differential.


Social feedback in the learning of a motor skill.


Religion and conceptual models of behaviour.


A further type of personal questionnaire technique.


The Symptom-Sign Inventory as a dignostic differentia for paranoid and non-paranoid schizophrenics.


Further investigation of the two personae of extraversion.


Thought-process disorder and personal construct subsystems.


Army mental health activities in Vietnam: 1965-1970.


Which soldiers break down. A survey of 610 psychiatric patients in Vietnam.


"Over the hump" in Vietnam. Adjustment patterns in a time-limited stress situation.


Mental health technicians in Vietnam.

Mental health technicians in Vietnam.


Liver biopsy with a needle of 0.7 MM outer diameter. Safety and quantitative yield.


Vertebral artery insufficiency and rotational obstruction.


Haemodynamic responses to sustained hand-grip in patients with hypertension.


Treatment of essential hypercholesterolemia with clofibrate and nicotinic acid.


Tubular reabsorption of calcium in the differential diagnosis of hypercalcaemia. Further experience.


Functional checking of implanted cardiac pacemakers. Methods, values indicative of impending pacemaker failure, and results of testing of fixed rate, ventricular synchronous and atrial synchronous pacemakers.


A two-year follow-up of persons with non-tuberculosis chest disease found at "operation doorstep", Vancouver 1964. Eight hundred and fifty-four patients of 928 who had attended a mass radiographic tuberculosis survey and in whom the diagnosis of non-tuberculous lung disease had been made, were located two years after the survey. This was the second follow-up survey of this group, the first having been at four months. The majority of patients were well, but 247 were ill and 101 had died. Serious non-tuberculous chest disease can be diagnosed with accuracy at mass surveys but the benefit to the patient of having these conditions detected is less clear. Serious progressive conditions that lead to death or ill health within two years appear to become symptomatic and force the sufferer to seek medical advice at about the same time that they are detected at mass surveys. This fact, coupled with the low yield of previously unknown tuberculosis, makes the future use of general mass radiographic surveys questionable in areas with good medical services. Evidence is presented that suggests screening directed to specific age groups may be more productive.


Prognostic significance of ECG-changes in survivors of myocardial infarction. Five-year follow-up study.


Cluster migraine--an unrecognized common entity. A review is presented of a distinctive type of vascular headache and its stereotyped features are emphasized, viz. severe non-throbbing character, unilateral and usually peri-ocular localization, frequent nocturnal occurrence and tendency to occur in brief episodes in a clustered pattern over weeks or months, with headache-free periods lasting months or years.Ten illustrative case histories are given and a plea is made for the early clinical recognition of this entity so that patients will not be submitted to unnecessary and potentially hazardous investigative procedures. While the common analgesics and narcotics are usually ineffective, ergotamine derivatives, methysergide and a new compound, BC-105, are highly effective forms of therapy.


Studies on the absorption and distribution of doxycycline in normal patients and in patients with severely impaired renal function. Doxycycline, a recently synthesized analogue of tetracycline, was given to 16 patients with normal renal function and to 14 patients with severely impaired renal function. Serum concentrations in the two groups following a single dose were followed after absorption. The rate of clearance from the plasma following a single dose did not differ significantly in the two groups despite low urinary concentrations in patients with renal failure. No accumulation of doxycycline occurred in the serum of three normal patients or of nine patients with renal failure when treated with either 200 mg. daily or 200 mg. initially followed by 100 mg. daily for up to 15 days.


Increased ratio of glycine-taurine conjugated bile acids in the early diagnosis of terminal ileopathy. Preliminary report.


Exocrine pancreatic function in porphyria cutanea tarda.


Clinical, metabolic and cardiovascular effects of different prostaglandins in man.


Proficiency in the detection and titration of blood group antibodies: results of an interlaboratory trial. Twelve numbered samples of serum were distributed to 82 Canadian blood transfusion laboratories. The presence or absence of blood group antibodies in these samples was correctly reported by less than 50% of participants; inability to demonstrate the presence of weak anti-D or anti-c was responsible for most of the failures. On the other hand, about 85% of participants reported titres of anti-D and anti-Fy(a) within an acceptable range. Two proposals are made that should help laboratories achieve a high and uniform level of proficiency in antibody detection and titration.


Disseminated actinomycosis.

Disseminated actinomycosis.


Medical care: changing needs and pattern.


Trauma Rounds. Montreal General Hospital. Fractured orbit (Case P67).


Pre- and post-natal growth acceleration and increased sugar consumption in Canadian Eskimos. A striking increase in birth weights and height measurements in children of Canadian Eskimos was observed in recent years.The growth acceleration seen to varying degrees in different Eskimo groups appears most closely to parallel the increase in the per capita annual sugar consumption which has more than quadrupled during the last decade in some trading areas of the Canadian Central and Eastern Arctic, while the per capita consumption of protein derived from animal sources shows a reverse relationship.Canadian Eskimos do, therefore, contrary to what is stated in earlier publications, conform to the general secular growth acceleration patterns observed in all populations coming under the influence of modern civilization. They do not, however, conform to the commonly held explanation for this acceleration, namely increased consumption of high-quality proteins, since their traditionally extremely high consumption of meat and fish decreased markedly during the same period.Our observations confirm the relation of growth acceleration and consumption of sugar first established by the Swiss pediatrician, Eugen Ziegler. A hypothesis first advanced by Ziegler is elaborated to link this growth acceleration, in particular the extraordinary increase in birth weight, to "pseudo-diabetic" oral glucose tolerance patterns described previously by the author in a large proportion of Eskimos.


Successful pregnancy in a patient with single ventricle and other congenital cardiac anomalies.


Mass surveys by chest radiography.

Mass surveys by chest radiography.


Disodium cromoglycate in the treatment of asthma.


Therapeutic abortion in a Canadian city.


Proteolytic enzymes. II. Studies on the requirement for the active center of trypsin with amidinobenzoates as substrates.


Effect of ionic head of cationic surface active agents on their hemolytic activity.


Effect of complex formation on the intestinal absorption of tryptophan.


Automated determination of urea nitrogen in serum with diacetyl monoxime-glucuronolactone reagent. (Organic analysis. 73).


The effect of xenogenic and allogeneic tumor cells on experimental metastasis with Ehrlich carcinoma.


Proteolytic enzymes. 3. Trans-4-aminomethylcyclohezane-1-carboxylic acid derivatives as substrates and an active site titrant of trypsin.


Chemical and cytotoxicity survey on the production of ochratoxins and penicillic acid by Aspergillus ochraceus Wilhelm.


Drug absorption, metabolism, and excretion. VI. Preparation of ether-type glucuronide of 4-hydroxyacetanilide.


Behaviour of plasma sugars after oral administration of lactose.


Adverse effect of antitumor drugs on the prevention of metastasis in mice.


Mechanics of distension of dog veins and other very thin-walled tubular structures.


Isoproterenol-induced myocardial infarction in rats. Distribution of corticosterone.


The investigation of the mental effects of trichlorethylene.


Effect of deoxycorticosterone acetate and aldosterone on the salt appetite of wild rabbits (Oryctolagus cuniculus (L.).


Fractionation and analysis of nuclear proteins in sea urchin embryos.


Molecular heterogeneity of soluble proteins and histones in relationship to the presence of B-chromosomes in rye.


Ultrastructure of the epithelium of the respiratory bronchioles in man.


The significance of pancreatic heterotopia in relation to cancer of the head of the pancreas.


The in vitro synthesis of subclasses of human gamma-G as demonstrated by a study of allotypes. The genes of the Gm system are they structural genes?


Thiamphenicol excretion in subjects with renal insufficiency.


Data on the tissue concentration of antibiotics in man tissue concentrations of semi-synthetic penicillins in the fetus.


The uptake of Hg203, Cu64, Mn52, and Pb212 by the intestinal wall of the duodenal and ileal segment in vitro.


The protective influence of haptoglobin on hemoglobinuric kidney. II. Microscopic observations and clinical aspect.


Note describing a sensitive spectrophotometric method for determination of isoniazid.


Preventive therapy with siblings of a dying child.


Crisis intervention and short-term therapy: an approach in a child-psychiatric clinic.


The male therapist and the female adolescent patient.


Therapeutic effectiveness of untrained volunteers with chronic patients.


Comparing behavior modification approaches to habit decrement--smoking.


Creativity, birth order, and preference for symmetry.


Private practice research.

Private practice research.


Birth order and scholastic aptitude and achievement.


Ego identity status, adjustment, and academic achievement.


Detection of brief tones in noise by rats. Two rats were trained to detect brief 8000-Hz tones centered in a one-third octave band of noise. The procedure was analogous to the yes-no method of human psychophysics in that one response was defined as correct and reinforced if the tone were present in the noise, and another response was correct and reinforced if the tone were absent. The percentage of correct responses was determined principally by the energy in the tone for the range of durations studied (75 to 600 msec): if the tone's duration were halved, for example, its power had to be doubled to keep the percentage of correct responses about the same. The ratio of the energy in the tone to the power per cycle of the noise needed to maintain 75% correct responses was about 36 db for one animal and 41 db for the other. Although the two responses were similar, and their consequences equal, biases in responding were sometimes observed.


Educating the diabetic patient.

Educating the diabetic patient.


Breast cancer treatment--a problem of selection.


Symmetry and asymmetry in interpersonal relations--with implications for the concept of projection.


Discrimination of auditory intensities by rats. Rats were trained to press one of two keys when a standard intensity value of a 4.0-kHz sine tone (70 or 100 db re 2 x 10(-4) microbar) was presented from a centrally located loudspeaker. Pressing the other key was reinforced when comparison intensity values (as much as 30 db less than the standard value) were presented. The animals initiated tone presentations by breaking a light beam at the rear of the chamber. Correct choices produced brain-stimulation reinforcement, and errors produced a timeout. A procedure designed by Jenkins was used to partial out choice data under potential control of sequential cues in the stimulus series. When the standard-comparison intensity difference was varied, the rats showed similar psychometric functions despite wide differences in response bias (relative position preference). A signal detection analysis showed that response biases for individual animals remained fairly consistent during psychophysical testing. The trend of decreasing choice accuracy at small intensity differences was described by the cumulative normal probability function. The similarity of psychometric functions obtained with 70- and 100-db standards supported Weber's law. There was some evidence that response latencies were controlled by intensity differences even when choice behavior was undifferentiated.


Radiolytic degradation of the peptide main chain in dilute aqueous solution containing oxygen.


Extended Hückel calculations on polypeptide chains. II. The phi-psi energy surface for a tetrapeptide of glycine.


Minimal apparent blood damage in Landé-Edwards membrane oxygenator at physiologic gas tensions.


Rehabilitation and civil commitment of addicts.


Increase of brain pyridolase phosphokinase activity following melatonin administration.


Studies on methylation of nucleic acids in crown gall tumor tissue cultures of tobacco.


Malnutrition and disease in pre-school Aboriginal children in the Walgett area of N.S.W.


Bacterial meningitis associated with a congenital dermal sinus.


Aliphatic hydrocarbon contents of various members of the family Micrococcaceae.


Hyperglycaemia in the urbanized Aboriginal. The Davenport survey.


Industrial skin cleaners.

Industrial skin cleaners.


The Chediak-Higashi syndrome.

The Chediak-Higashi syndrome.


Hyperthyroidism in systemic lupus erythematosus.


Venous ulceration--a further factor.

Venous ulceration--a further factor.


Data processing in general practice.

Data processing in general practice.


Safety belts in motor vehicles: their compulsory wearing.


Oxygen therapy in acute respiratory failure.


Influenza immunization.

Influenza immunization.


Casualties of war.

Casualties of war.


Cleft lip and cleft palate.

Cleft lip and cleft palate.


Legg-Perthes' disease.

Legg-Perthes' disease.


Chromosomal abnormalities and spontaneous abortion.


Rifampicin and thrombocytopenia.

Rifampicin and thrombocytopenia.


Breast cancer in old age.

Breast cancer in old age.


Health problems of Sydney Aboriginal children.


Embolizing paraneoplastic endocarditis with lethal myocardial infarction (description of a case).


Bioevaluation of dietary iron in growing rats. V. Response of rats to different levels on meat in a stimulated Finnish diet.


Casein and gluten diets of the same protein value. Long-term ad libitum feeding tests with young rats.


A comparison of radioisotope imaging devices using plane source distributions.


Variation of response of the FeSO4 dosemeter with temperature of the solution during irradiation.


Congenital abdominal coarctation with renal artery hypoplasia, hypertension and rheumatoid arthritis.


Clasmatosis: ultrastructure of cytoplasmic fragments from the spleen, lymph nodes, and thymus of the rat.


Altruistic behavior by children.

Altruistic behavior by children.


An intake report outline for behavior modification.


Antimitotic agents and macronuclear division of ciliates IV. Reassembly of microtubules in macronuclei of Tetrahymena adapting to colchicine.


Tissue distribution and dosimetry of 144Ce in Chinese hamsters.


Mechanism of action of radiation protective agents. In vivo distribution and metabolism of cysteamine-S-phosphate (MEAP).


Olfactory esthesioneuroma.

Olfactory esthesioneuroma.


The structure of mezerein, a major toxic principle of Daphne mezereum L.


[Isolation and absolute configuration of the aeroplysinin I enantiomorphic pair from ianthella ardis].


Cardiological investigations by the use of magnetic materials.


Cerebral angiography and electroencephalography in cerebrovascular disease.


Changes in cellular properties during the long-term serial culture of lung cells of newborn hamster and the transformation into A cells.


Ca flux and action potential in smooth muscle of guinea-pig taenia coli.


An outbreak of Mycoplasma pneumoniae infection in a community.


Delayed hypersensitivity reaction to succinylcholine.


Difference of cellular properties of D cells between two hamster cell lines carried in media fortified with different kinds of albumin.


ECHO virus type 22 infection in a premature infant.


Longitudinal study on maturation patterns of EEG basic waves of infants fed on milk from mothers with low serum folate levels.


Manometric and cineradiographic studies on anorectal motility in Hirschsprung's disease before and after surgical operation.


Maturation patterns of EEG basic waves of healthy infants under twelve-months of age.


Ballistocardiography simplified by recording microvibration of the skin surface of the head.


Removal of barriers to family planning.

Removal of barriers to family planning.


The pathology and incidence of the D & E trisomies in Jamaica.


Fibrous tissue tumours of the neck in children.


Beta-thalassaemia Hb E disease.

Beta-thalassaemia Hb E disease.


The role of anaerobic metabolism in the urine concentration mechanism.


Experience with 100 cases of gastroscopy with the GTFA gastrocamera.


Pyloric stenosis in Jamaica.

Pyloric stenosis in Jamaica.


A survey of nurses' attitudes to psychiatric patients in two general hospitals in Jamaica and Trinidad.


Health education--old wine in new medicine bottles?


Spermtatogenesis in animals as revealed by electron microscopy. XX. Relationship between chromatoid bodies and centriole adjunct in spermatids of grasshopper, Acrida lata.


Combined treatment with aminocaproic acid and subcutaneous heparin in the prevention of thrombosis following prostatectomy.


Myocardial infarction and coronary atherosclerosis among, and comparison between urban and rural population in Finland.


Flavin-photosensitized reactions of retinol and stilbene. 1. Retinol and stilbene are both isomerized when they are illuminated anaerobically in the presence of flavins. 2. Triplet quenchers (e.g. oxygen, potassium iodide and paramagnetic ions) inhibit the reaction more efficiently than they quench flavin fluorescence. At 77 degrees C in a diethyl ether-isopentane-ethanol (5:5:2) glass retinol quenches flavin phosphorescence, but not its fluorescence. 3. For the stilbene reaction cis/trans photostationary-state mixtures are obtained with different flavins and these are linearly related to the phosphorescence transition energies of the flavins used. 4. The reaction involves the triplet state of flavin and a scheme for the reaction is suggested. 5. The dependence of the rate of reaction on substrate concentration is explicable in terms of this scheme. 6. The photobleaching of rhodopsin sensitized by flavin is also demonstrated.


Preparatin, proteolysis and reversible oxidationof highly purified Azotobacter vinelandii polynucleotide phosphorylase. 1. A new method has been developed for the preparation in good yield of highly purified Azotobacter vinelandii polynucleotide phosphorylase in its reduced form. 2. Aging or digestion with trypsin causes the enzyme to develop a primer requirement that is not eliminated by beta-mercaptoethanol. 3. The development of a primer requirement is accompanied by marked changes of the electrophoretic mobility of the enzyme in polyacrylamide gels. 4. The enzyme is inactivated by aerial oxidation or thiol-specific reagents. The lost activity is restored by beta-mercaptoethanol, but not by oligonucleotide primers.


Bacteriolytic enzymes from Staphylococcus aureus. Properties of the endo-beta-N-acetylglucosaminidase. An extracellular bacteriolytic endo-beta-N-acetylglucosaminidase has been purified and its specificity of action has been investigated (Wadström & Hisatsune, 1970a,b). Some enzymic properties, such as optimum pH for enzyme activity on whole cells and cell walls of Micrococcus lysodeikticus and Staphylococcus aureus and optimum pH for stability, have been studied. The activity was maximum in 0.05m-tris-hydrochloric acid buffer, pH7.0. A higher ionic strength inhibited cell-wall hydrolysis. Since the crude and purified enzymes were found to be unstable on storage, the stabilizing and inhibiting effects of several compounds were investigated. Several heavy metal ions inactivated the enzyme at very low concentrations. Thiol compounds stabilized and thiol-reacting compounds partly inhibited the activity. Crude and purified glucosaminidase was found to be heat-stable at acidic pH and unstable at alkaline pH as previously found for several lysozymes (endo-beta-N-acetylmuramidases). Other properties of the staphylococcal enzyme and hen's-egg-white lysozyme have been compared, since the modes of action of the two are quite similar (Wadström & Hisatsune, 1970b).


Kinetic studies with cytosol and mitochondrial phosphoenolpyruvate carboxykinases. 1. Measurements of Michaelis constants for oxaloacetate in the reaction catalysed by liver phosphoenolpyruvate carboxykinase give values much lower than previously reported. With Mg(2+) as bivalent cation, the Michaelis constant was approx. 2.5x10(-5)m whether the enzyme used was the mitochondrial phosphoenolpyruvate carboxykinase purified from sheep liver or chicken liver or the cytosol enzyme purified from rat liver or sheep liver. 2. When Mn(2+) replaced Mg(2+) in the reaction a lower Michaelis constant of 9x10(-6)m was found, but only with the mitochondrial enzymes. 3. With all enzymes malate at high concentration was a competitive inhibitor with respect to oxaloacetate when Mn(2+) was the added cation. With Mg(2+) the inhibition by malate was competitive with the mitochondrial enzymes and non-competitive with the cytosol enzymes.


Chemical properties of guinea-pig immunoglobulins gamma-1 G, gamma-2 G and gamma M. The isolation of guinea-pig immunoglobulins gamma(1)G, gamma(2)G and gammaM are described and methods for separating the polypeptide chains of each examined. The molecular weights, extinction coefficients and carbohydrate and amino acid compositions of the immunoglobulins and their constituent chains have been analysed. The findings provide a basis for further studies attempting to relate structural differences to distinct biological properties of guinea-pig immunoglobulins.


The reverible dissociation and activity ofribosoma subunits of liver and skeletal muscle from rats. Ribosomal subunits were prepared from rat liver and skeletal muscle after incubation with puromycin and treatment at low concentrations of Mg(2+). After isolation the resulting subunits could be recombined and the particles effected the synthesis of polyphenylalanine in the presence of polyuridylic acid. Hybrid particles formed from subunits of liver and muscle respectively were also active. The homogeneity of the isolated subunits was checked by polyacrylamide-gel-agarose electrophoresis. The method is shown to be a reliable and comparatively simple way of preparing active ribosomal subunits from skeletal muscle.


Determination of high-affinity oestrogen receptor sites in uterine supernatant preparations. An assay method was developed for the determination of high-affinity oestradiol receptors in uterine supernatant preparations. When only high-affinity sites are present in such preparations, or when they predominate, the analysis of the equilibrium between oestradiol and receptor sites based on the Scatchard (1949) plot may be used to determine the dissociation constant of the equilibrium and the molar concentration of the high-affinity sites. When both high-affinity and low-affinity sites are present the Scatchard plot is no longer linear and cannot be used directly to determine high-affinity sites. Determination of the reverse velocity constants of the reaction between high-affinity (k(-1)) and low-affinity (k(-2)) receptor sites and [(3)H]oestradiol has shown that these constants differ by at least one order of magnitude. Advantage has been taken of this difference to introduce an additional step into the assay procedure that eliminates oestradiol bound to low-affinity sites and permits the determination of high-affinity sites in different species and under a variety of physiological conditions.


Changes in the concentration of high-affinity oestradiol receptor in rat uterine supernatant preparations during the oestrous ycle, pseudopregnancy, pregnancy, maturation and after ovariectomy. A quantitative method was used to determine the concentration of high-affinity oestradiol-receptor sites in rat uterine supernatant preparations under various physiological conditions. Cyclic changes in concentration were observed during the oestrous cycle, with a maximum occurring in late dioestrus. The changes followed a similar pattern in endometrium and myometrium, although concentrations were higher in the former. In pseudopregnancy the concentration was initially low, rising to a maximum on the tenth day. In early pregnancy a high concentration of receptor was found to be associated with the developing placenta, but this declined in later stages of pregnancy. After ovariectomy or combined ovariectomy and adrenalectomy the receptor concentration remained at a constant low value that could be increased by treatment with oestradiol. The receptor concentration was considerably higher in immature than in adult uteri.


The concentration of amino acids by yeast cells depleted of adenosine triphosphate. 1. The ATP content of preparations of a strain of Saccharomyces carlsbergensis was lowered below 0.3nmol/mg of yeast by starving the yeast cells in the presence of both antimycin and 5mm-deoxyglucose. 2. When the depleted cells were put at pH4.5 with glycine up to about 20nmol of the amino acid/mg of yeast was absorbed without being chemically modified. The mechanism did not depend on an exchange with endogenous amino acids. 3. The concentration of the absorbed glycine could apparently reach 100-200 times that outside the cells. 4. Replacement of the cellular K(+) by Na(+) almost stopped amino acid absorption in the presence of antimycin and deoxyglucose, but not in their absence. 5. It is suggested that, when energy metabolism itself had stopped, a purely physical process, namely the movements of H(+) and K(+) into and out of the yeast respectively, served to concentrate the amino acids in the cells. Both ionic species appear to be co-substrates of the system transporting amino acids.


Interctions between potassium ions and glycine transport in the yeast Saccharomyces carlsbergensis. A study has been made of the effects of both varying the pH and extracellular [K(+)] on the initial rate of uptake of glycine (v) by a strain of Saccharomyces carlsbergensis that concentrated the amino acid, with respect to the extracellular phase, by up to 1400 times. When no other substrate than glycine was provided and [glycine] was relatively small (</=0.2mm) (1) v increased fivefold when the pH was lowered from 7 to 4.5; (2) v fell by up to about 80% as [K(+)] rose, K(+) behaving as a non-competitive inhibitor of the system, with K(i) 0.33mequiv./l at pH7; (3) the absorption of glycine caused up to about 2 or 3 equiv. of K(+) to leave the yeast cells. These three phenomena were each less evident when glucose was present. An analogy is drawn between the respective interactions of H(+) and K(+) with the yeast system and the well recognized effects of Na(+) and K(+) on amino acid transport in certain mammalian systems.


The dissociation of chicken erythrocyte deoxyribonuleoprotein and some properties of its partial nucleoproteins. Histones were completely dissociated from their native complex with DNA in 2.0m-sodium chloride. Histone fractions IIb, V and I were dissociated in 1.2m-sodium chloride, fractions V and I in 0.7m-sodium chloride and fraction I in 0.45m-sodium chloride. Repeated extraction of partial dRNP (deoxyribonucleoprotein) preparations with sodium chloride of the same concentration as that from which they were prepared resulted in release of histones that previously had remained associated with the DNA of the complex. Gradual removal of histones from dRNP was paralleled by an improvement in solubility, a decrease in wavelength of the u.v.-absorption minimum, and a fall in sedimentation coefficient of the remaining partial dRNP. X-ray diffraction patterns of partial dRNP preparations showed that removal of histone fractions I and V from dRNP did not destroy the super-coil structure of the dRNP, but further removal of histones did. Infrared spectra of partial dRNP preparations showed that in native dRNP histone fraction I was present in the form of extended, isolated polypeptide chains, and that the other histone fractions probably contain a helical component that lies roughly parallel to the polynucleotide chains in the double helix and an extended polypeptide component that is more nearly parallel to the DNA helix axis. An analysis of the sedimentation of partial dRNP preparations on sucrose gradients showed that native dRNP consists of DNA molecules each complexed with histone fractions of all types.


Some aspects of clinical allergy.

Some aspects of clinical allergy.


Isolation of some precursors of 2-methylpyrrole in the Elson-Morgan reaction. 1-C-(1-Acetylacetonyl)-2-deoxy-2-(1-methyl-3-oxobut-1-enyl)amino -d-galactitol is obtained from the condensation of 2-amino-2-deoxy-d-galactose with pentane-2,4-dione in anhydrous solvent. On treatment with hot alkali it gives 2-methylpyrrole with 37% yield. By acid hydrolysis under mild conditions the compound loses the N substituent and from the resulting unstable derivative 2-methylpyrrole is obtained (52% yield). It is concluded that derivatives of aminohexoses substituted at C-1 with a dioxopentyl chain are the precursors of 2-methylpyrrole in the Cessi & Serafini-Cessi (1963) modification of the Elson-Morgan reaction. As demonstrated previously, products of condensation of aminohexoses with pentane-2,4-dione at the amino group are not converted directly into 2-methylpyrrole, but this step provides protection of the amino group during condensation at C-1.


Major pulmonary embolism.

Major pulmonary embolism.


Oxygen therapy: its current place in medical practice.


Coronary thrombosis.

Coronary thrombosis.


Social and ethnic differences in understanding the spoken word.


The speech of deaf and partially-hearing children with special reference to factors affecting intelligibility.


Orofacial musculature imbalance among mentally retarded children.


The long term effect of auditory masking on young stutterers.


Notes on patterns of development found by using the qualitative phonetic assessment sheet of the Edinburgh articulation test.


Attitudes expressed by families of aphasics.


Speech therapy in the British Isles--license to practice.


The use of morphological rules by four year old children: an item analysis of the auditory-vocal automatic subtest of the Illinois test of psycholinguistic abilities.


Central effects of 6-hydroxydopamine on the body temperature of the rat. 1. Rats which had been pretreated with intraventricular injections of 6-hydroxydopamine (6-OHDA) to cause a selective depletion of brain noradrenaline (NA) to 20.7% of control brain NA and brain dopamine (DA) to 34.6% of control brain DA retained an unimpaired ability to regulate their body temperatures on exposure to heat or cold. This is discussed in relation to the possible role of brain NA in the central control of body temperature.2. Intraventricular injections of 6-OHDA in normal rats at room temperature caused an acute, dose dependent hypothermia of up to 4.5 degrees C which lasted for 4-5 hours. Depletion of brain NA and DA by prior treatment with 6-OHDA markedly reduced the hypothermic response to a subsequent dose of 6-OHDA. Selective depletion of brain NA without affecting brain DA did not reduce the response to 6-OHDA. The acute hypothermic response to 6-OHDA, may therefore, be related to a release of DA in the brain.


Acceleration of noradrenaline biosynthesis in the guinea-pig vas deferens by potassium. 1. Increasing the concentration of KCl in Krebs-Henseleit bicarbonate solution enhanced the formation of (14)C-noradrenaline ((14)C-NA) from (14)C-tyrosine in the guinea-pig vas deferens. In 52 mM KCl Krebs-Henseleit solution the specific activity of the newly formed (14)C-NA was double that of controls.2. The rate of synthesis of (14)C-NA from (14)C-tyrosine was constant for up to 2 h in 52 mM KCl Krebs-Henseleit solution and for 4 h in unmodified Krebs-Henseleit solution.3. There was no increase in NA formation in the presence of KCl rich Krebs-Henseleit solution if (14)C-DOPA was used as the starting substrate instead of (14)C-tyrosine.4. The specific activity of (14)C-tyrosine in the high KCl treated vas deferens was 80% of that of control tissues. Thus the enhanced synthesis of (14)C-NA in high KCl Krebs-Henseleit solution did not arise from an increase in the specific activity of precursor.5. The effect of K(+) on NA synthesis was not mimicked by ganglionic stimulants nor blocked by tetrodotoxin.6. Removal of Ca(2+) ions or increasing the concentration of Mg(2+) ions abolished the increase in synthesis of NA seen in high KCl Krebs-Henseleit solution but left the basal rate of NA synthesis in unmodified Krebs-Henseleit solution unaltered.7. The spontaneous release of newly synthesized catecholamines ((14)C-labelled) or tritiated noradrenaline ((3)H-NA) from vasa deferentia was increased in 52 mM KCl Krebs-Henseleit solution. Removal of Ca(2+) ions reduced the increased efflux of newly synthesized amine in high KCl media to that seen in unmodified Krebs-Henseleit solution. The efflux of (3)H-NA was reduced to one-third of its former rate in the absence of Ca(2+).8. High KCl Krebs-Henseleit solution caused a substantial contraction of the vas deferens which was not abolished by tetrodotoxin. Release of (3)H-NA paralleled the contractile response, and was likewise unaffected by tetrodotoxin.9. No evidence was obtained for any alterations in the activity of tyrosine hydroxylase, the rate limiting enzyme in the formation of NA from tyrosine, in homogenates of vas deferens which had been treated with 52 mM KCl Krebs-Henseleit solution.10. These results support the hypothesis that acceleration of NA synthesis occurs when tyrosine hydroxylase is freed from end-product inhibition by the release of noradrenaline, brought about in this case, by high concentrations of KCl.


Effects of catecholamines infused into the brain of young chickens. 1. (-)-Noradrenaline, (-)-alpha-methylnoradrenaline and (-)-isoprenaline were infused into various brain regions of 12-21 day chicks. When infused into the hypothalamic area, but not the cerebral hemisphere or posterior mesencephalon, these amines produced behavioural sleep, lowered temperature and blood pressure and reduced oxygen consumption; electrocortical sleep activity usually ensued but this was not marked and frequently dissociation between electrocortical activity and behaviour occurred. After monoamine oxidase inhibition, which prolonged the action of noradrenaline, dopamine had similar effects.2. The effects of the catecholamines were prevented or substantially reduced by pretreatment with phenoxybenzamine given intravenously or into the hypothalamus but not by intravenous injection of propranolol. However, intrahypothalamic infusion of propranolol prevented the temperature, but not the behavioural effects of noradrenaline. The implications of this are discussed.3. That the effects were similar but more intense, apart from electrocortical changes, and of longer duration than those seen after intravenous injection of catecholamines suggests that in young chicks these amines penetrate from the blood into the brain and elicit their effects through a localized region, presumably the hypothalamus.


An investigation of alpha-methyl amino-acids and their derivatives on isolated tissue preparations. 1. The ability of alpha-methyl amino-acids and their corresponding amines to restore the sympathomimetic actions of tyramine, and the uptake of the amino-acids and the amines, were studied in isolated tissue preparations obtained from reserpine pretreated animals.2. Tyramine relaxed isolated rat ileum preparations from non-reserpinized rats but not from reserpine treated animals. alpha-Methyldopa, alpha-methylnoradrenaline and lower concentrations of metaraminol restored the responses of reserpinized preparations. alpha-Methyldopamine, alpha-methyl-m-tyrosine, alpha-methyl-p-tyrosine and higher concentrations of metaraminol did not do so. The restoring effect of alpha-methyldopa was blocked by disulphiram. alpha-Methyl-p-tyrosine or alpha-methyl-m-tyrosine blocked the restoring action of alpha-methyldopa but not of alpha-methylnoradrenaline. Cocaine blocked the restoration of responses to tyramine by alpha-methylnoradrenaline but not by alpha-methyldopa. alpha-Methyldopa and alpha-methylnoradrenaline failed to restore responses to tyramine in the presence of sodium-free Tyrode solution.3. Tyramine increased the perfusion pressure in isolated rabbit ear preparations obtained from non-reserpinized animals but was very much less active in preparations obtained from reserpine treated animals. alpha-Methyldopa, alpha-methyl-m-tyrosine, alpha-methylnoradrenaline, alpha-methyl-p-tyrosine and metaraminol restored the effects of tyramine. alpha-Methyldopamine did not do so. The restoring effect of alpha-methyldopa and alpha-methyl-m-tyrosine was blocked by disulfiram. alpha-Methyl-p-tyrosine blocked the restoring effect of alpha-methyl-m-tyrosine.4. Tyramine produced positive inotropic effects in isolated rabbit heart preparations. This was either reduced or absent in preparations obtained from reserpine pretreated animals. alpha-Methyldopa, alpha-methylnoradrenaline, alpha-methyl-m-tyrosine and metaraminol restored the responses to tyramine. alpha-Methyldopamine and alpha-methyl-p-tyrosine did not do so.


Effect of caerulein on protein synthesis and secretion in the guinea-pig pancreas. 1. Caerulein produced a striking increase in the rate of secretion of the guinea-pig pancreas. When tested in vivo with pancreatic slices its optimal concentration was found to be 2.5 ng/ml. In vivo the intravenous injection of 400 ng/kg and the subcutaneous injection of 4 mug/kg of the drug produced marked secretory responses.2. Neither incubation of pancreatic slices in vitro for various lengths of time in the presence of caerulein nor the intravenous injection of the drug brought about any detectable changes in the rate of (14)C-L-leucine incorporation into protein of pancreatic slices incubated in vitro. By contrast, a two-fold increase in the incorporation of leucine was found in fasting animals injected subcutaneously with caerulein twice a day for 4 days. The same treatment in fed animals, or one single dose of caerulein injected subcutaneously 4 h before killing in guinea-pigs starved for 4 days did not affect the rate of incorporation. Moreover the long term treatment with the cholinergic segretagogue bethanechol in fasted guinea-pigs was also ineffective.3. It is concluded (a) that in the guinea-pig pancreas, stimulation of enzyme secretion does not affect per se the rate of synthesis of digestive enzymes; and (b) that the increase of protein synthesis elicited by caerulein is critically dependent both on the nature of the segretagogue (that is, it is elicited by the polypeptide but not by a cholinergic drug) and on the experimental conditions (it is evident only in fasted animals after prolonged treatment).


Time course of the effects of 6-hydroxydopamine on catecholamine-containing neurones in rat hypothalamus and striatum. 1. The effects of intraventricular injection of 6-hydroxydopamine (6-OHDA) on tyrosine hydroxylase activity, uptake of (3)H-noradrenaline and endogenous catecholamine concentration in rat hypothalamus and striatum were investigated at various times after the injection of 6-OHDA.2. In the hypothalamus after the injection of 250 mug of 6-OHDA there was a rapid decrease in tyrosine hydroxylase activity, (3)H-noradrenaline uptake and noradrenaline content, which was essentially complete within 2 hours.3. In the striatum after this dose of 6-OHDA there was a much slower reduction in tyrosine hydroxylase activity and (3)H-noradrenaline uptake during the first 48 h after drug injection. For the first 24 h the dopamine concentration in this brain area was increased significantly above control values, but had fallen below control values by 48 hours.4. After the injection of a smaller dose of 6-OHDA (25 mug) the only detectable change in the striatum was a rapid increase in the dopamine concentration. In the hypothalamus this dose induced a rapid depletion of noradrenaline, not accompanied initially by any significant reduction in tyrosine hydroxylase activity.5. These results are consistent with the hypothesis that 6-OHDA causes a rapid degeneration of catecholamine-containing nerve terminals in the central nervous system (CNS). These degenerative changes, indicated by the loss of tyrosine hydroxylase and noradrenaline uptake sites, did not appear to be preceded by an initial displacement of endogenous catecholamines by 6-OHDA, except possibly at early times after the administration of small doses of the drug.


Effects of intraventricular 2,4,5-trihydroxyphenylethylamine (6-hydroxydopamine) on rat behaviour and brain catecholamine metabolism. 1. 6-Hydroxydopamine (200 mug injected intraventricularly) caused depletion of noradrenaline from all regions of rat brain within 2 h after injection but depletion of dopamine in the brain was observed only from 2 days after injection. Both catecholamines remained depleted for more than 32 days.2. Rats treated with intraventricular 6-hydroxydopamine were sedated and lethargic, with reduced spontaneous and exploratory activity, for periods of up to 8 days after injection. Conditioned avoidance responding was abolished or reduced for a similar period.3. Intraventricular 6-hydroxydopamine caused a prolonged reduction in the amount of labelled catecholamines in store 4 h following an intraventricular injection of (3)H-dopamine. During the first 6 h after 6-hydroxydopamine injection, there was a marked increase in neutral and acid metabolites from the labelled catecholamines.4. A comparison of the behavioural and biochemical effects of intraventricular 6-hydroxydopamine and reserpine suggests that both drugs affect catecholamine storage mechanisms but by different mechanisms. It was not possible from these experiments to correlate behavioural changes with either catecholamine storage or metabolism.


Uptake of monoamines into central neurones and the blood-brain barrier in the infant rat. 1. A fluorescence histochemical study was undertaken to investigate the ability of systemically administered monoamines to penetrate into the central nervous system of infant rats.2. It was found that after subcutaneous injections of large doses, L-noradrenaline, L-alpha-methyl-noradrenaline, DL-alpha-methyl-dopamine, L-alpha-methyl-dopa and 5-hydroxytryptamine could cross the blood-brain barrier of newborn to 2 week old rats and be taken up by neurones normally containing monoamine as well as by several neurones which normally contained no monoamine.3. 5-Hydroxytryptamine containing neurones took up 5-hydroxytryptamine as well as catecholamines and alpha-methyl-dopa. The pinealocytes, which contain large amounts of 5-hydroxytryptamine, were depleted of their endogenous fluorescence by alpha-methyl-dopa and showed no selective uptake of catecholamines.4. The uptake of monoamines was not antagonized by previous reserpine treatment or by inhibition of catecholamine synthesis, and occurred throughout the whole extent of the monoamine-containing neurones (cell body, axon, terminals).5. The monoamines were also taken up by the endothelial cells and pericytes of capillaries in the central nervous system (CNS) which are thought to constitute the physical barrier to these substances in the adult.6. The peripheral sympathetic nerves to pial blood vessels, the pineal and pituitary glands also took up the monoamines and alpha-methyl-dopa; uptake was also noted in cells of the pituitary gland, in epithelial and connective tissue elements of the meninges and choroid plexuses and in the epithelial, connective and muscular tissue of pial blood vessels.7. It is concluded that the blood-brain barrier to monoamines may not be fully developed in infant rats, at least for high levels of circulating monoamines; the central monoamine-containing neurones possess the ;membrane pump' mechanism for uptake of monoamines from the time of birth, even though they are not fully developed morphologically.


Two toxins from a poisonous sample of mussels Mytilus edulis. 1. A crude preparation of toxin was extracted from a sample of mussels Mytilus edulis, part of a batch responsible for many cases of paralytic shellfish poisoning.2. The crude extract was partially purified by absorption on sodium Amberlite ion-exchange resin. Two toxins were recovered by elution from the Amberlite, and purified further by gel filtration.3. One toxin closely resembled saxitoxin in its behaviour on Amberlite and in its biological effects.4. The other toxin behaved quite differently on the Amberlite. Its molecule was small, comparable in size with saxitoxin. It was not tetrodotoxin. Its biological effects were similar, but not identical, to those of saxitoxin: it paralysed muscular contraction and inhibited conduction along nerves; it caused death of experimental animals by producing a peripheral paralysis of respiration; it did not depolarize the membrane of frog skeletal muscle fibres, but acted by preventing a stimulus from initiating a conducted action potential.5. The biological effects of the second toxin suggest that, like saxitoxin and tetrodotoxin, it is an inhibitor of inward sodium ion movement through electrically excitable membranes.


A simple method for measuring a picogram of acetylcholine using the clam (Mya arenaria) heart. 1. A simple and reliable method is described for assaying 1 pg or less of acetylcholine (ACh) using a strip of clam (Mya arenaria) heart.2. Clam heart preparations generally are extremely selective for ACh. The preparation described is at least 10(5) times less sensitive to the following: acetyl coenzyme A, adrenaline, choline, dopamine, gamma-aminobutyric acid, glutamic acid, histamine, 5-hydroxytryptamine and noradrenaline.3. Because this preparation is one of the most sensitive known for detecting ACh, it should prove useful for assaying particularly low levels of this substance in biological extracts.


GABA and hippocampal inhibition.

GABA and hippocampal inhibition. Bicuculline, a specific GABA antagonist, diminishes basket cell inhibition of hippocampal pyramidal neurones, an inhibition which is not affected by strychnine.The inhibitory transmitter released by basket cells is thus probably GABA.


[Continuous monitoring of the peripheral circulation with digital photoplethysmography. Its importace in anesthesia-resuscitation].


Influence of the antrum on the acid response to distension of the body of the stomach in dogs.


Effect of vagotomy on the acid response to gastric distension.


Effect of increased dietary phosphorus on calcium metabolism of young rats.


Pulmonary fate of histamine, isoproterenol, physalaemin, and substance P.


Effect of radiation on lecithin metabolism, surface activity, and compliance of rat lung.


The static elastic properties of carotid arteries from fetal sheep.


The identification of acetyl-l-carnitylcholine in rat brain extracts and the comparison of its cholinomimetic properties with acetylcholine.


Tolerance of unacclimated and cold-acclimated rats to exercise in th cold: serum, red and white muscle enzymes, and histological changes.


3H-2-glucose in turnover studies.

3H-2-glucose in turnover studies.


The effect of a standardized 'skin insult' on transepidermal water loss from clinically resolved dermatitic skin.


The quantitative analysis of some constituents of crude sweat.


Disseminated intravascular coagulation presenting with cutaneous symptoms.


Thermal induced sweating in tattooed skin.


Selective renal arteriography in renal tumors. II. Benign tumors and cysts.


CaSO4-Mn dosimetry in dental x-ray diagnosis.


Psychological factors affecting pain tolerance.


Physiological changes during spontaneous panic attacks.


The Social Readjustment Rating Scale: a cross-cultural study of Western Europeans and Americans.


Correlates of the desire to be held in women.


Prediction of near-future health change from subjects' preceding life changes.


The development and evaluation of a pneumatic barrier for restraining surface oils in a river.


Economics of thermal pollution control.

Economics of thermal pollution control.


Design of activated carbon adsorption beds.


Establishing water quality standards--an industrial viewpoint.


Demonstration of two mitochondrial populations y rate zonal centrifugation.


Differential sensitivity of the protein-synthesizing system of rat liver to 8-azaguanine.


Homoepathy.

Homoepathy.


Dentists' dilemma.

Dentists' dilemma.


The emotional tone-scale ladder.

The emotional tone-scale ladder.


Whither therapeutic abortion?

Whither therapeutic abortion?


Advertising and smoking.

Advertising and smoking.


Alcohol and the heart.

Alcohol and the heart.


Simple liquid scintillation counting of tritium incorporated in mouse bone marrow.


Selective aldosterone deficiency in chronic pyelonephritis.


LDH isoenzyme pattern of rat kidney in mercurial intoxication.


Reverse osmosis as a method of preparing dialysis water.


Radiology in the management of arterio-venous shunts. Review of 60 poorly functioning shunts.


Cystinuria, hyperuricemia and uric acid nephrolithiasis. Case report.


[Pathogenesis of pulmonary hypertension].


A two-year follow-up of 181 sputum-positive tuberculosis patients treated in Gateshead between 1961 and 1966.


Twice-weekly streptomycin plus isoniazid for tuberculosis.


Observer and experimental variation in tuberculin testing.


New colorimetric micromethod for the estimation of gamma-glutamyl transpeptidase activity in biological samples.


Herring bodies; an electron microscopic study of local degeneration and regeneration of neurosecretory axons.


Electron microscopic studies on the oocyte maturation in cultures of juvenile rat ovaries.


The arginase inhibitor from sunflower seeds: purification and inhibitory properties.


The variations in the content of triterpenoids in the developing flowers of Calendula officinalis L.


Hydrolysis of 5-cyano-, and decarboxylation of 5-carboxy-, uracils: a facile route to the synthesis of analogues of 1-cyclohexyluracil and cytosine.


Effect of maleate on glutamate oxidation by rat liver mitochondria.


Intermediates in the synthesis of purines and pteridines: N-methylated 6-chlorouracils.


Carboxylation of propionyl-CoA in erythromycin biosynthesis.


Conformation of acid forms of poly C: temperature and ionic strength dependence of protonation of cytidine and cytidine-5'-phosphate.


Electroreduction of halogenopyrimidines. Electrochemical reduction of 5-halogenoderivatives of uracil, its nucleosides and oligonucleotides.


Photochemistry of 5-ethyluracil and its glycosides.


Regulation of lactose utilization in Aspergillus nidulans.


The electrical evaluation of muscle relaxation in anesthesia.


A simplified technique of blind nasotracheal intubation of patients with respiratory insufficiency.


Diagnosis and treatment of tracheal collapse after thyroid operation.


A failure of the pin-index system of anesthetic gas tube connections. A case report.


A simple electrode for monitoring the ECG during anesthesia.


Maintenance of an adequate circulation during anesthesia.


The effect of haloperidol with promethazine on postoperative vomiting.


Aspects of operability.

Aspects of operability.


Pre-operative administration of fluids.

Pre-operative administration of fluids.


Factors determining the end-tidal concentration of halothane--a theoretical analysis.


A comparison of neuroleptanesthesia and halothane in neurosurgery.


The influence of supranormal temperatures on the nucleolus of Hela-S3 cells exposed to the antibiotic toyocamycin.


Carotenoid pigments of Stigmatella aurantiaca (Myxobacterales). II. Acylated carotenoid glucosides.


Relative susceptibilities of caffeine-sensitive and caffeine-resistant strains of Candida albicans to inactivation and mutation by ultraviolet radiation.


Immunologic effects of cyclophosphamide treatment in rheumatoid arthritis.


Synovectomy in rheumatoid arthritis. A retrospective study.


Oxygen tension in synovial fluids.

Oxygen tension in synovial fluids.


Gold nephropathy. A clinical and pathologic study.


Epidemiologic studies on systemic lupus erythematosus. Comparative data for New York City and Jefferson County, Alabama, 1956-1965.


Zvaifler NJ: Synovial fluid findings in systemic lupus erythematosus (SLE).


The nephrotic syndrome as a complication of gold therapy.


Rheumatoid constrictive pericarditis, treated by pericardiectomy. Report of a case and review of the literature.


Iron-induced arthritis in immature rabbits.


Particulate matter in I.V. infusion fluids.


LeClair challenges hospital boards.

LeClair challenges hospital boards.


Manufacturers can play creative role in purchasing.


Relapsing polychondritis with aortic involvement.


It's time governments tell it "like it is".


Hospital austerity--B.C. style.

Hospital austerity--B.C. style.


Will Parcost ease the patient's financial burden?


What volunteers have to offer a children's hospital.


Hemarthrosis and sickle cell trait.

Hemarthrosis and sickle cell trait.


Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.


Equipment for preparing and inspecting disposable glass syringes.


Continuous high speed filling and nitrogen freezing of lyophilized products.


Utilization of Rondo unscrambler and Strunck units in ampul inspection.


Evaluation of sustained tion parenteral emulsions.


Biological effects of anthramycin methyl ether. I. Acute intestinal necrosis.


The in vitro action of mammalian sex hormones on Staphylococcus aureus.


Biological effects of anthramycin methyl ether. II. Inhibition of DNA synthesis in the intestinal epithelium and sarcoma-180 tumor cells.


A new method of intracardiac emergency pacing, ECG, and pressure monitoring by means of microcatheterization. Annotation.


Clinical evaluation of cephalexin in the treatment of urinary tract infections.


Faecal fat excretion, diarrhea, and subjective complaints with highly dosed oral fat intake.


The effect of ambient temperature on restraint ulcer in the rat.


Electric activity of the vascular wall and release of tissular factors of blood clotting after adrenaline injections.


Biochemical, morphological and haematological changes in guinea-pigs fed with cholesterol diets having a different fatty acid composition.


Pancreatic secretion of bicarbonate in patients with chronic pancreatitis.


Scanning of the stomach with 99mTc.

Scanning of the stomach with 99mTc.


Cardiac effects of oxyfedrine in the cat.


Peritonitis caused by candida albicans.

Peritonitis caused by candida albicans.


Stimulatory effects of catecholamines on the isolated rat colon after beta-adrenergic blockade with oxprenolol and propranolol.


Glucagon: its effect upon myocardial oxygen consumption.


Selective lowering of brain serotonin by p-acylphenylethylamines.


Effect of chlorpromazine on 5-hydroxytryptamine metabolism in hippocampal stimulated rats.


Effects of nicotine and tyramine on contractile activity of the colon.


Effects of metoclopramide on isolated guinea-pig colon. 1. Peripheral sensitization to acetylcholine.


Effect of changes in ionic environment on the action of bradykinin on the guinea-pig taenia coli.


Intrinsic plasma kinin formation in man, dog and rat.


Effects of metoclopramide on isolated guinea-pig colon. 2. Interference with ganglionic stimulant drugs.


Chronic reserpine treatment on adrenergic neuronal and receptor function in the isolated perfused mesenteric blood vessels of the dog.


Diurnal variation in sensitivity to and metabolism of barbiturate in the rat: lack of correlation between in vivo and in vitro findings.


Inclusion of predivision labeled nuclear RNA in post division nuclei in Amoeba proteus.


The role of the nucleus in the formation and maintenance of the contractile vacuole in Amoeba proteus.


Influence of ions, inhibitors and anoxia on transtrophoblast potential of rabbit blastocyst.


Evidence for an antagonistic action of diazoxide at alpha-adrenergic receptors in rabbit aorta.


Reversible interaction of human lymphocytes with the mitogen concanavalin A.


In vivo incorporation of labeled amino acids into nuclear proteins of the sea urchin embryos.


Factors influencing exogenous nucleoside utilization in DNA synthesis by irradiated human cells.


Localization and conformation of polyribosomes bound to chloroplast lamellae.


Quantitative relation between hydrostatic pressure gradient, extracellular volume and active sodium transport in the epithelium of the frog skin (R. temporaria).


Lymphocyte stimulation: the effect of ouabain on nucleic acid and protein synthesis.


The effect ofgrowth hormone on DNA synthesis in rat spleen.


Cold storage as a method for accumulating mitotic HeLa cells without impairing subsequent synchronous growth.


Cytokinesis at prophase in plant cells treated with ethidium bromide.


Arrays of thick filaments in ATP-activated Amoeba model cells.


Oscillation of individual generation times in cells lines of Tetrahymena pyriformis.


Analysis of human metaphase chromosome set by aid of DNA-binding fluorescent agents.


Aqueductal stenosis as the cause of hydrocephalus in mice fed the substituted hydrazine, cuprizone.


Structural and functional changes in polysomes from ischemic livers.


Occurrence of Z-band widening in human atrial cells.


Lymph vessels of rat aorta and their changes in experimental atherosclerosis: an electron microscopic study.


Increased DNA synthesis in aortic explants from swine fed a high-cholesterol diet.


Analysis of stable iodinated insulin by neutron-activation techniques.


Clinical experience with piperacetazine in hospitalized mental patients. A four year study.


Influence of the level of the carbon source on the autolysis of Aspergillus niger.


Complete heart block in myocardial infarction.


A study of the antigenic relationships of isolates of Trypanosoma brucei collected from a herd  of cattle kept in one locality for five years.


Mycoplasmal pneumonia.

Mycoplasmal pneumonia.


To orient or not to orient--that is the question.


Corneal absorption reinforcement of certain mydriatics.


X-ray conference. Traumatic carotid-cavernous sinus fistula.


Mechanism of tetracycline resistance in Staphylococcus aureus.


Pharmacokinetic model for chlordiazepoxide--HCl in the dog.


Molecular scale drug entrapment as a precise method of controlled drug release. 3. In vitro and in vivo studies of drug release.


Interactions of drugs with proteins. II. Experimental methods, treatment of experimental data, and thermodynamics of binding reactions of thymoleptic drugs and model dyes.


Solubility of alkyl benzoates. I. Effect of some alkyl p-hydroxybenzoates (parabens) on the solubility of benzyl p-hydroxybenzoate.


Molecular scale drug entrapment as a precise method of controlled drug release. II. Facilitated drug entrapment to polymeric colloidal dispersions.


Selected pharmacological studies of a series of substituted imidazo(4,5-d)pyridazines.


Binding specificity between small organic solutes in aqueous solution: classification of some solutes into two groups according to binding tendencies.


Mathematical optimization techniques in drug product design and process analysis.


Alkaloids of Tylophora. II. Structural studies.


Allylic phosphate hydrolysis. Kinetics and mechanism of degradation of 3-beta,17-alpha-dihydroxy-6-alpha-methylpregn-4-en-20-one 17-acetate, 3-phosphate.


pH effects on salicylate absorption from hydrophilic ointment.


Salt effects in aqueous solutions of urea.


Comparison of plasma concentrations of warfarin measured by both simple extraction and TLC methods.


Common receptor-complement feature among some antileukemic compounds.


Theoretical justification of reciprocal rate plots in studies of water vapor transmission through films.


Potential anticancer agents. VI. 5-Substituted pyrimidine-6-carboxaldehydes.


Colorimetric determination of atropine, homatropine, scopolamine, and their derivatives by the ferric hydroxamate method.


Assay of emetine hydrochloride injection.


Colorimetric and gas chromatographic analyses of arecoline in capsule preparations.


Characterization of the content uniformity plan.


Solid-phase synthesis and degradation of a model polypeptide by an automated approach.


Teratogenic effects of audiogenic stress in albino mice.


Molecular association of barbital and caffeine in 2:1 crystalline complex.


Influences of heredity and environment on alkaloidal phenotypes in Solanaceae.


Complexes of ergot alkaloids and derivatives. IV. Investigations into the nature of ergot alkaloid--xanthine complexes.


Absolute configuration of (+)-trans-2-o-tolylcyclohexanol by x-ray crystallography.


Critical evaluation of extraction procedures in determination of atropine and scopolamine from Datura powder.


First pKa values of some acid-base indicators.


Dipole moment and structure of thiophene derivatives and benzene analogs.


New compounds: potential antineoplastics. VI. 2,4-Diamino-6-hydroxy-5-arylazopyrimidines and 1,3-dimethyl-5-arylhydrazonoalloxans.


Solubility relationships in urea-water systems.


Preparation of bis(acetylthiobenzyl)sulfide.


Low-frequency rescue of a genetic marker in deoxyribonucleic acid from Bacillus bacteriophage phi 105 by superinfecting bacteriophage. Markers in gene L, which maps at the right end of the vegetative and prophage maps, are rescued at a strongly reduced frequency from mature phi105 deoxyribonucleic acid (DNA) by superinfecting phage but at high frequency from vegetative and prophage DNA. It is suggested that the ends of mature DNA are degraded when DNA is taken up by competent cells.


Mapping of prophage and mature deoxyribonucleic acid from temperate Bacillus bacteriophage phi 105 by marker rescue. By using temperature-sensitive (ts) and suppressor-sensitive (sus) mutants, 11 essential genes have been identified in phage phi105. The order of the genes has been established in two- and three-factor crosses. The genes can be arranged in a linear order; this order is identical in the vegetative phage and in the prophage. One gene essential for phage deoxyribonucleic acid (DNA) synthesis has been found. Marker rescue from prophage and mature DNA, taken up by competent bacteria, was studied by superinfection with phage carrying one sus and one ts mutation. In prophage DNA, all single markers studied are rescued at similar frequencies. The frequency of co-rescue of two markers is proportional to the recombinational distance between the markers. Thus, colinearity between the genetic map and the position on the DNA molecule of those mutations used to establish the map is demonstrated. The results indicate that the recombination frequencies observed in vegetative crosses are a relative measure of the physical distance between markers. All single markers are not rescued at equal frequencies from mature DNA. The frequency of co-rescue of two markers is related to the recombinational distance only over a distance about one-fourth or less of the genetic map. Markers separated by 10% recombination, or more, are co-rescued at 5 to 10% of the frequency of rescue of single markers. Shearing of mature DNA into half-sized molecules reduces the efficiency by which single markers are rescued by a factor of 5 to 10. The results of experiments on co-rescue of two markers from half-sized mature DNA indicate a preferred break-point near the middle of the genetic map; the results are compatible with a nonpermuted sequence in mature DNA. It is pointed out and discussed that mature DNA exhibits several anomalies in marker rescue experiments.


Properties of Caulobacter ribonucleic acid bacteriophage phi Cb5. The ribonucleic acid (RNA) bacteriophage phiCb5, which specifically infects only one form of the dimorphic stalked bacterium Caulobacter crescentus, has been obtained in high yield. Since the phage is extremely salt-sensitive, a purification procedure was devised which avoided contact with solutions of high ionic strength. Phage phiCb5 was studied with respect to the physical and chemical properties of both the phage and its RNA. In an electron microscope, the phage particles appear as small polyhedra, 23 nm in diameter. The phage is similar to the Escherichia coli RNA phages in that it (i) sediments at an S(20, w) of 70.6S, (ii) is composed of a single molecule of single-stranded RNA and a protein coat, (iii) contains two structural proteins, and (iv) apparently contains the genetic capacity to code for a coat protein subunit, a maturation-like protein, and an RNA polymerase. Phage phiCb5 differs from the E. coli RNA phages in (i) host specificity, (ii) salt sensitivity, and (iii) the presence of histidine, but not methionine, in the coat protein.


The African species of Strychnos. I. The ethnobotany.


The distribution of tyramine, N-methyltyramine, hordenine, octopamine, and synephrine in higher plants.


Catharanthus alkaloids. XXV. Isolation of leurosine and ursolic acid from C. pusillus.


Purification and properties of a nonspecific hemagglutinin from the peanut (Arachis hypogaea).


Biological and phytochemical evaluation of plants. 8. Isolation of a new alkaloid from Sanguinaria canadensis.


The effect of antibiotics on the growth of Catharanthus roseus tissue cultures.


Microbiological hydroxylation of 4-androstene-3,17-dione.


Saccharomyces capensis--an inositolless yeast.


Fusarium javanicum Koorders in Israel.

Fusarium javanicum Koorders in Israel.


Surgery for ptosis and strabismus in ocular myopathy.


Oculomyodynamometry. The strength and work of extraocular muscles in squint.


Extremity fractures in children. 3. Lower extremity.


How to interpret electrocardiographic interpretations. 2.


New developments in anticonvulsant therapy.


Should pregnant patients gain more weight?


Causes of chronic diarrhea in infants and children.


Rational chemotherapy for aging.

Rational chemotherapy for aging.


How I treat granuloma annulare.

How I treat granuloma annulare.


Hyperlipoproteinemias and dietary treatment.


Seminal dialogues on psychiatric problems. On being "high". 1. What is being "high"?


Evaluation of tests for rheumatoid factor.


Instrumentation for expanding intensive care.


Thoracentesis: a modified technic.

Thoracentesis: a modified technic.


A quantitative procedure for the determination of cortisol and corticosterone in blood plasma.


Mass spectrometric studies on methyl ether derivatives of sterols.


The influence of spironolactone on its own biotransformation.


Conversion of 3-keto-5-beta-cholanoic acid to lithocholic acid by guinea pig brain tissue, in vitro.


A sensitive sulfuric acid-ethanol induced fluorescence reaction for testosterone and androstenedione.


An orally active long-acting estrogen (AY-20,121).


The isolation of 31-norcyclolaudenone from Musa sapientum.


Cleansing the approach from biases in the study of underdeveloped countries.


Chinese economic policy.

Chinese economic policy.


Epidemiology of Rocky Mountain spotted fever and murine typhus.


The problem of chronic hepatitis.

The problem of chronic hepatitis.


Coagulation testing in the surgical patient.


Treatment with lithium carbonate. Results in 35 cases.


Quinidine intoxication from alkali ingestion.


Lateral unilobular thyroid.

Lateral unilobular thyroid.


Trends in cerebral palsy treatment.

Trends in cerebral palsy treatment.


A pictorial review: radiological findings in nonspecific ulcerative colitis.


Immunological aspects of bovine trypanosomiasis. II. Antigenic variation in a strain of Trypanosoma congolense transmitted by Glossina morsitans.


The pathology of African trypanosomiasis.


Electronic cytochemical demonstration of a lysosome in Leishmania donovani.


Pathogenicity of Trichomonas hominis to splenectomized rats.


Field trial of cycloguanil pamoate in the treatment and suppression of malaria in Nigerian school children: a preliminary report.


Helminth and protozoal parasites of the Hadza of Tanzania.


Schistosomiasis and diabetes mellitus.

Schistosomiasis and diabetes mellitus.


The schistosomal circumoval precipitin test in cases of chronic prostatitis.


The potentiating effect of pyrethrins and pyrethroids on the action of organophosphorus larvicides in Simulium control.


Lymphangioadenopathy of filariasis.

Lymphangioadenopathy of filariasis.


Iron loss and reabsorption in Ancylostoma duodenale infection and bilharzial colonic polyposis. Individuals infected with Ancylostoma duodenale may lose up to 6 mg of iron daily and those infected with bilharzial colonic polyposis may lose an average of 3 mg daily; patients suffering with both infections may lose up to 9 mg of iron daily.  1 study has shown that some iron loss to the upper gastrointestinal tract was reabsorbed.  A study was undertaken to ascertain whether any iron lost in the lower gastrointestinal tract is reabsorbed and to measure the amount of iron reabsorbed in patients with A. duodenale.  7 Egyptian farmers with A. duodenale and 8 with bilharzial intestinal polyposis but without hookworm infection were given thorough physical and laboratory examinations.  Hookworm and Schistosoma mansoni egg counts were performed.  All patients were given oral ferrous sulfate before starting the experiment to raise their hemoglobin levels to over 10 gm %.  The mean daily blood loss in the 7 patients with heavy hookworm infections was 64.8 ml and the mean iron loss was 18.7; but a mean of 7.7 of this iron was reabsorbed.  In the 8 patients with bilharzial polyposis, blood loss averaged 13.1 ml and iron loss, 4.3 mg.  In 4 patients, the amount of iron reabsorbed was not significant, in the remaining 4, it reached only 2 mg.  The reabsorption of 40% of the iron initially lost in the upper gastrointestinal tract may explain the remarkable tolerance of Egyptian farmers to prolonged hookworm infections.  The general iron deficiency anemia prevalent among patients with bilharzial polyposis is due in part to the loss of iron which is not reabsorbed.


Trichomonas sp. from reptiles of Ceylon.


Progress towards the control of bilharziasis in Iran.


Survival and viability of Brugia microfilariae in stored blood.


Experimental infection of gibbons with Dirofilaria immitis.


Aspergilloma and residual tuberculous cavities--the results of a resurvey.


A study on the frequency of 'atypical' mycobacteria in Japanese National Sanatoria.


Disease caused by 'atypical' (opportunist) mycobacteria: a whole population review.


Lung fibrosis and cavitation mimicking tuberculosis.


Isolation of 'atypical' mycobacteria from healthy individuals in tropical Australia.


Detection of rifampicin in urine by a simple microbiological assay.


False elevation of serum aspartate aminotransferase in patients with pulmonary tuberculosis during administration of sodium aminosalicylate.


Carotene and xanthophylls in mycobacteria. I. Technical procedures; thin-layer chromatographic patterns of mycobacterial pigments.


A survey of erythema nodosum in a rural community between 1954 and 1968.


'Original mycobacterial sin'.

'Original mycobacterial sin'.


ABO blood groups and pulmonary tuberculosis.


Jaundice associated with rifampicin.

Jaundice associated with rifampicin.


Risk of infection.

Risk of infection.


Determination and identification of sympathomimetic amines in blood samples from drivers by a combination of gas chromatography and mass spectrometry.


Use of ninhydrin to purify extracts of putrefied biological specimens.


Analysis of methaqualone in autopsy material.


On the development of the blood island in Xenopus laevis embryos: light and electron microscope study.


Epidermal ridge configurations in a boy with triploid-diploid mosaicism.


Two-gene hypothesis for hairy pinnae of the ear.


Inheritance of an unusual ear tye in man.


Twinning in Nigeria.

Twinning in Nigeria.


Frequency of consanguineous marriages in Madhya Pradesh.


Sex differences in skin colour in man.

Sex differences in skin colour in man.


Behavior theory and problems of the deaf.


Report of a program for emotionally disturbed deaf boys.


Student assessment according to a developmental sequence of educational goals: inventory.


Reinforcing appropriate visual attending behavior in classes of deaf children.


The conformational energy map of an alanyl residue preceding proline: a quantum-mechanical approach.


Requirement for HCO3- by ATP: urea amido-lyase in yeast.


Choline kinase as an allosteric enzyme.

Choline kinase as an allosteric enzyme.


Mechanism of dissociation of pigeon liver fatty acid synthetase complex into half-molecular weight subunits and their reassociation to enzymatically active complex.


Molecular properties of local anesthetics: the crystal structure of 2-diethylaminoethyl p-methoxybenzoate hydrochloride.


Bisulfite-catalyzed transamination of cytosine and cytidine.


Structural studies on gastric mucoproteins: lowering of molecular weight after reduction with 2-mercaptoethanol.


The synthesis of ribosomal-type RNA by isolated rat liver mitochondria.


A complex of functionally-bound enzymes: transketolase and glyceraldehydephosphate dehydrogenase.


Mass spectrometry of DNP-amino acids combination with paper chromatography.


Carbon dioxide fixation and the synthesis of aspartate by Microbacterium thermosphactum.


Evidence for the location of methionyl-lysyl-bradykinin moieties at the carboxyl terminus and inside of bovine kininogen-I.


Liberation of Agrobacterium tumefaciens DNA from the crown gall tumor cell DNA by shearing.


Mitochondrial protein synthesis: resistance to emetine and response to RNA synthesis inhibitors.


Lingual positions of cleft palate patients with and without velopharyngeal closure.


Experimental interference with auditory feedback.


Air flow in the upper register.

Air flow in the upper register.


Effect of ouabain on contractility of the isolated ureter.


The effects of stretching the rabbit bladder. Preliminary observations.


Catheters for studies of urinary tract pressure.


Simultaneous determination of glomerular filtration rate and effective plasma flow by external monitoring of radioisotopes. An experimental study in dogs.


Bladder regeneration following serosal colocystoplasty.


Secretory activity of the rabbit vas deferens.


Radioisotope 69mZn chloride prostate gland scan. I. 69mZn organ distribution studies and gamma-camera scan in canine subjects.


The podiatrist in the hospital.

The podiatrist in the hospital.


The Polokoff hallux shield.

The Polokoff hallux shield.


Kinetics of hydrolysis of orthophosphate monoesters by canine prostatic acid phosphohydrolase.


Neurodermatitis. A case report.

Neurodermatitis. A case report.


A case of gout in a 15-year-old.

A case of gout in a 15-year-old.


Clinical evaluation of the efficacy of oral trypsin in reducing edema postoperatively in foot surgery: a preliminary study.


Nondisplacement of rat tissue riboflavin by 7-chloro-8-methyl-flavin and the stimulation of intestinal synthesis of riboflavin.


Nutritional effects induced in rats by feeding natural and synthetic trypsin inhibitors.


Lysine requirement of the growing rat: plasma-free lysine as a response criterion.


Effects of high but nontoxic levels of zinc in practical diets on 65Zn and zinc metabolism in Holstein calves.


Utilization of L-methionine sulfoxide by the rat.


Influence of dietary lipid on lipogenesis and on the activity of malic enzyme and citrate cleavage enzyme in liver of the growing chick.


Urinary methylmalonate and hepatic methylmalonyl coenzyme A mutase activity in the vitamin B12-deficient rat.


Effects of dietary zinc and calcium on the retention and distribution of zinc in rats fed semipurified diets.


Alcohol and traffic safety.

Alcohol and traffic safety.


Calcium metabolism in ponies fed varying levels of calcium.


Studies on the formation of endogenous ethanol in blood putrefying in vitro.


Clay ingestion (geophagia) as a source of zinc for rats.


The relation of dietary choline and methionine to phospholipid synthesis in the rat.


Inhibition of calcium absorption and elevation of calcium removal rate from bone in fluoride-treated calves.


Cardiac metabolism in thiamin deficiency in rats.


Sarcoidosis and chronic hepatic disease: a clinical and pathologic study of 20 patients.


Relative annual frequencies of cancers, 1940-1970.


Patterns and prognosis of advanced breast carcinoma.


Detection for lung cancer: present methods and their worths.


Granular cell ameloblastoma of the mandibular symphysis. Case report.


Hospital-based education at Ellis Fischel State Cancer Hospital and the Cancer Research Center.


CAMEO--Cancer Management and Education Optimization.


Cushing's disease as a psychosomatic disorder. A report of ten cases.


Who are they?

Who are they?


Care of the teeth: the nurse's view.

Care of the teeth: the nurse's view.


Care of the teeth: dentures.

Care of the teeth: dentures.


A mechanism for carotenoid synthesis in fungi involving a multifunctional enzyme complex.


The mechanism of competence in the transformation of streptococci of serological group H. Transformation of the marker of the competence factor from S. challis to S. wicky.


Different photodynamic action of proflavine and methylene blue on bacteriophage. I. Host cell reactivation of Serratiaphage kappa.


Selection and characterisation of mutants lacking arginase in Neurospora crassa.


A nursing experience in Belgium.

A nursing experience in Belgium.


The ribosomal proteins of Drosophila melanogaster. I. Characterization in polyacrylamide gel of proteins from larval, adult, and ammonium chloride-treated ribosomes.


Embryology made easy. 2. Development of the placenta and umbilical cord.


Augmentation mammaplasty.

Augmentation mammaplasty.


Some aspects of tetanus based on observations in East Anglia 1928--1969.


Wilson's disease. A nursing study of the physical and psychological manifestations.


Geriatric care.

Geriatric care.


Salmon: its objectives and achievements as seen from the centre.


Blood sample survey.

Blood sample survey.


Fibrosarcoma of the brain. A case report describing response of the primary and metastatic tumors to radiotherapy.


Variation of the transmembrane potential level as a basic mechanism of mitosis control.


Antidiuretic hormone (ADH). Hypersecretion syndrome in the course of acute intermitent porphyria (considerations with reference to two cases).


Behçet's disease with renal involvement (with reference to three anatomico-clinical cases).


The role of serum proteins in determination of the neuropsychial syndrome in the course of chronic hepatopathies and their chromatographic separation.


Functional innervation of the adipose tissue and the role of the mast cells in lipid metabolism.


Asphyxiating thoracic dystrophy (Jeune's syndrome). Radiological findings.


Pulmonary nocardiosis.

Pulmonary nocardiosis.


Difficulties in the diagnosis of benign tumours of the stomach.


Exposure of the facial nerve in the tympanic portion without dislocation of the malleus and incus.


Increased antipyrine half-life in women taking oral contraceptives.


Congenital dislocation of the hip.

Congenital dislocation of the hip.


Practical steps towards the prevention of bronchial carcinoma.


Fluorine distribution in rats following acute intoxication with nitrogen and halogen fluorides and with sodium fluoride.


Changing pattern of care for the intellectually handicapped.


Toxicology of nitrogen trifluoride.

Toxicology of nitrogen trifluoride.


Time-dependent changes in toxicity of rotenone dispersions to trout.


Indomethacin-induced intestinal lesions in the rat.


Comparative toxicologic study with polychlorinated biphenyls in chickens with special reference to porphyria, edema formation, liver necrosis, and tissue residues.


Some features of the reaction between cobaltinitrite and hemoglobin.


Toxicologic studies with 2,6-di-tert-butyl-4-hydroxymethylphenol in the rat.


Toxicity of paraquat to rats and its effect on rat lungs.


Some aspects of interaction between diphenylhydantoin and digoxin by simultaneous administration to dogs.


Toxicity of DDT to Japanese quail as influenced by body weight, breeding condition, and sex.


The acute hyperbaric toxicity of carbon monoxide.


Temporal aspects of carbon tetrachloride-induced alteration of sulfobromophthalein excretion and metabolism.


Ammonia toxicity in rats: protection by alpha-methylglutamic acid.


Dieldrin excretion by the isolated perfused rat liver: a sexual difference.


The gamble on high risk students.

The gamble on high risk students.


Distribution of I-131-labeled abrin in vivo.


Snake venom toxins. I. Preliminary studies on the separation of toxins of Elapidae venoms.


Thermostability of the venom of the scorpion Leiurus quinquestriatus (H. et E.).


A study on sea-snake venom phospholipase A.


Epidemiology and general management of poisoning by pesticides.


Tetanus toxin and muscle relaxation.

Tetanus toxin and muscle relaxation.


Octopus neurotoxins: low molecular weight non-immunogenic toxins present in the saliva of the blue-ringed octopus.


A suggested medium for maintaining Fasciola hepatica prior to in vitro experimentation.


Changes in the synovial fluid caused by osmic acid.


Social class and sex differences in admission patterns of the mentally retarded.


Ovulation inhibition with a long-acting injectable contraceptive. IV. Return of reproductive function after discontinuation.


Lochia and menstrual patterns in women with postpartum IUCD insertions. 185 postpartum women were inserted with 30-mm Lippes loops on the third or fourth postpartum day to determine the effects of lochia and menstrual patterns.  100 postpartum without IUDs were used as a control group.  Hemoglobin and bacteriological studies were done periodically in both groups and amount of lochial discharge and menstrual patterns were recorded.  The period of lochia averaged 31.2 days in the study group and 23.3 days in the control group.  The amount of lochia was excessive in 40% of the study group as compared with 11% of the controls, and menorrhagia was more often seen in the study group (20% and 7%, respectively).  No difference in hemoglobin levels or bacterial count was noted.


Roentgenographic findings in lipoid proteinosis: a case report.


Chronic post-rheumatic fever (Jaccoud's) arthropathy.


Rheumatoid arthritis in Ugandan Africans.


Giant granulomatous lesions of the femoral head and neck in rheumatoid arthritis.


Ultrastructure of articular cartilage in experimental immobilization.


Mode of aggregation of hyaluronic acid protein complex on the surface of articular cartilage.


Hip disease in juvenile rheumatoid arthritis.


Synovial perfusion of clinically normal knee joints in patients with rheumatoid arthritis. An isotope study.


Rheumatoid factor in cases of rheumatic fever and parasitic infestation in children.


Cyclophosphamide in systemic lupus erythematosus.


Nuclear bodies in rheumatoid synovium.

Nuclear bodies in rheumatoid synovium.


Quantitative aspects of the latex-fixation and Whaaler-Rose tests.


Anatomo-clinical forms and haemodynamics of chronic ischaemia at the upper end of the femur.


Hip involvement in juvenile chronic polyarthritis.


Tendinous ruptures in rheumatoid arthritis.


Felty's syndrome: a clinical and pathological survey of 21 patients.


Hepatic effects of fenzlozic acid.

Hepatic effects of fenzlozic acid.


Follow-up studies on synovectomy of the knee in rheumatoid arthritis.


A study in vivo of the stiffness of the human knee.


Mechanism of the fall in complement level in the synovial fluid in cases of rheumatoid polyarthritis.


Rheumatoid rosettes (significance of the phenomenon).


Observations on the clinical outcome and recovery of hypothalamo-pituitary-adrenal axis function after complete withdrawal of long-term corticosteroid therapy in patients with rheumatoid arthritis.


The technetium scintigram as an indicator of synovial vascularity in rheumatoid arthritis: its comparison with the results of temperature measurement.


A rich source of replicative ribonucleic acid of Sindbis virus--a potent interferon inducer.


The immunological status of the bone marrow cells of sheep erythrocyte-tolerant rats.


A short duration group treatment of smoking behavior by stimulus saturation.


[Studies on the combined use of killed and live measles vaccines. V. Five year follow-up].


The inhibition of N-acetyl-beta-D-glucosaminase by the (1-4)-and (1-5)-lactones of N-acetylglucosaminic acid. The inhibition of N-acetyl-beta-d-glucosaminase activity by 2-acetamido-2-deoxy-d-gluconolactone was examined. Separation of the (1-->4)- and (1-->5)-lactones was achieved by using paper chromatography or countercurrent distribution and identification was obtained by examination of the relative stability of the components of separated material. Quantitative measurement of the two lactones was by kinetic titration or by a colorimetric method based on their reaction with hydroxylamine. It was shown that only the (1-->5)-lactone acted as an inhibitor of N-acetyl-beta-d-glucosaminase.


Circular dichroism of calf liver nucleohistone.


Transcriptive expression during sea urchin embryogenesis.


Haemoptysis in cystic fibrosis.

Haemoptysis in cystic fibrosis.


Some size and charge properties of tomato pectin methylesterase.


Hydroxylation of N-(4-chlorophenyl)[14C1] acetamide to N-(4-chlorophenyl)-[14C1] glycolamide in rabbits.


Bioassay of thyroid stimulating hormone using the f goldfish. A new method for the bioassay of thyroid stimulating hormone using goldfish is described. The technique can detect thyroid stimulating substances in euthyroid unconcentrated plasma. Early results show that the method compares well with other techniques. Some evidence has been obtained which suggests that in primary myxoedema there may be some impairment of the thyropituitary "servo-mechanism" in older patients.


An 11-year review of primary tumours of the small bowel including the duodenum.


Subacute sclerosing panencephalitis: isolation of a measles-like virus in tissue culture of brain biopsy.


First derivative of ventricular pressure recorded by means of conventional cardiac catheters.


Use of computers in monitoring a psychiatric treatment program.


The effects of various prior treatments upon the transport of chlorpromazine and trifluoperazine into rat brain.


Attempted suicide. Some statistical and psychiatric parameters. I.


Thessaly variant of glucose-6-phosphate dehydrogenase.


Hypnotic age regression: an empirical and methodological analysis.


Liver changes in leprosy.

Liver changes in leprosy.


Organizational goals and quality of medical care: evidence from comparative research on hospitals.


Seasonal variations in probable neurosecretory cells in the ganglia of Littorina littorea (L.).


The structure and function of ribonuclease T. X. Reactions of iodoacetate, iodoacetamide and related alkylating reagents with ribonuclease T.


College students as companions to long-term mental hospital patients: some considerations.


Metabolic clearance rate of radioiodinated human calcitonin in man. The characteristics of the disappearance of radioiodinated synthetic human calcitonin from plasma have been studied in man. After single injection the disappearance curve was multiexponential. The number of exponentials of the theoretical curve fitting the best with the experimental data varied individually. Metabolic clearance rate was determined both from single injection and constant infusion studies, and fast initial distribution volume from the former. Metabolic clearance rate values in normal man calculated from constant infusion studies were 82.3 +/-3.4 ml/min per m(2). Values derived from single injection studies were similar, 77.0 +/-4.7 ml/min per m(2). These results were compared to those obtained in end stage, renal failure patients. Metabolic clearance rate was considerably lower and volume of fast initial distribution slightly larger in that group. This fact emphasizes the important role of kidneys in the utilization and/or the degradation of human calcitonin.


Factors affecting the choice of medical care among university students.


Lymphocytes and yellow fever. I. Transient virus refractory state following vaccination of man with the 17-D strain.


A field trial for evaluation of the prophylactic effect of influenza vaccine containing inactivated A2-Hong Kong and B influenza viruses.


A deleted B chromosome in a mosaic mother and her cri du chat progeny.


The position of autosomal glucose-6-phosphate dehydrogenase on linkage group 8 of the mouse.


Wegener's granuloma complicating pregnancy.


Punishment, stuttering, and disfluency.

Punishment, stuttering, and disfluency.


Stereospecificity of anesthetic activity, distribution, inactivation and protein binding of the optical antipodes of two N-methylated barbiturates.


A comparison of the results of pressure articulation testing in various contexts for subjects with cleft palates.


Comparison of sentence identification and conventional speech discrimination scores.


The effect of surgical operation on the velocity of venous return from the legs.


The role of syntax in children's comprehension from ages six to twelve.


Possible hazards of handling anti-neoplastic drugs.


Reye's syndrome and salicylate intoxication.


1969 results on mosquito control research.


Panel: legislative activities.

Panel: legislative activities.


Biological factors affecting the radioprotective efficiency of S-2-[2-aminopropylamino] ethylphosphorothioic acid (WR-2721). LD50(3)) doses.


Evolutionary divergence in Hawaiian Drosophila.


Antiparkinson drug overuse.

Antiparkinson drug overuse.


The effects of a contrast medium (sodium iothalamate, 80 percent) on left ventricular function.


The response of growth hormone to xylitol administration in man.


The alveolar macrophage: pulmonary frontiersman.


Ethics of intensive treatment.

Ethics of intensive treatment.