Glutamate uptake and aspartate formation during oxidation of glutamate in a brain mitochondrial fraction.


Cholinesterase-containing neurones in the spinal cord of the rat.


Changes in acetylcholinesterase, acid phosphatase and beta glucuronidase proximal to a nerve crush.


Incorporation of (Me-14C)choline into phosphatidyl choline of rat cerebral cortex membranes in vitro.


Effect of superior cervical sympathectomy on experimentally induced intracranial hypertension.


Photographic analysis of rat behavior before and after amygdaloid lesions.


Photically-induced epilepsy and glucose metabolism in the adolescent baboon (Papio papio).


Computer analysis of some cat parahippocampal unit firing patterns.


Blocking by picrotoxin of both vestibular inhibition and GABA action on rabbit oculomotor neurones.


The effects of glycine, GABA and strychnine on sacral parasympathetic preganglionic neurones.


GABA as a repressor of L-glutamic acid decarboxylase (GAD) in developing chick embryo optic lobes.


Basal ganglia-diencephalon synaptic relations in the cat. I. An intracellular study of dorsal thalamic neurons during capsular and basal ganglia stimulation.


Electrophysiological concomitants of spreading depression in caudate and thalamic nuclei of the cat.


Glutamate decarboxylase in inhibitory neurons. A study of the enzyme in Purkinje cell axons and boutons in the cat.


Depth discrimination in rats following removal of visual neocortex.


Adaptation of neural taste responses in cat.


Effects of the stimulation of paleocerebellum on certain vegetative functions in the cat.


Effect of neonatal thyroidectomy on enzymes in subcellular fractions of rat brain.


The effect of halothane on preganglionic and postganglionic sympathetic activity in the cat.


Excitability cycles in central intermittency.


Past history of adult bronchitis.

Past history of adult bronchitis.


Prevalence of respiratory allergy among children and adolescents in Geneva, Switzerland.


Constitutional factors in children with asthma and recurrent bronchitis at school age.


A study of recurrent bronchitis in childhood.


Regression of radiological changes in asthma following treatment.


Social aspects of cystic fibrosis.

Social aspects of cystic fibrosis.


Physiological aspects of ultrasonic aerosols.


3rd International Symposium on Asthma and Chronic Bronchitis in Children and their prognosis into Adult Life, Davos (Switzerland), October 23-24, 1969.


Anatomical evolution of 'bronchitis' of the childhood bronchiectasis, correlations with the therapeutic resection.


7-chlorolincomycin in cystic fibrosis.

7-chlorolincomycin in cystic fibrosis.


Long term corticosteroid treatment and growth.


Methods for evaluation of pulmonary function in infants and preschool children.


The post natal development of the human lung and its implications for lung pathology.


Respiratory and cardiovascular consequences of scoliosis.


Symptoms of chronic non specific lung disease (CNSLD) in a group of school children--with a follow-up after three years.


Protective effect of pyridoxal-5-phosphate on glutamate decarboxylase from lupin seeds.


Studies on frog muscle glycogen synthetase. Factors affecting its activity.


Oxygen consumption and tissue oxygen tension as a function of the hematocrit in polycythemic mice.


Plasma iron in domestic fowl.

Plasma iron in domestic fowl.


Phosphorolytic and transferase activities of the purine nucleoside phosphorylase from human erythrocytes.


Effect of intestine irradiation in the absence of sodium on the oxygen uptake.


Sialic acids. XII. On the nature of the acylneuraminic acids from human normal urine.


The effect of absence of sodium on the respiratory metabolism of rat liver.


Effect of spironolactone in hypertensive patients.


Bubble oxygenator and screen oxygenator effects on ventricular performance: a mathematical analysis of ventricular function curves.


Renal function in Wilson's disease: response to penicillamine therapy.


Academic dress.

Academic dress.


A new method for measuring the acidity of gastric juice.


Surgical treatment of heart block. A four year experience with implantable pacemakers.


Congenital intestinal obstruction.

Congenital intestinal obstruction.


Study on the treatment of myopia in pupils of the primary and middle schools of Nose Town.


Hemangio-endothelioma occurring in the soft part of the knee joint: a case report.


Special characteristics of absorption and excretion of chloramphenicol in premature and newborn infants.


The measurement of the electric activity of the skin in clinical anesthesia.


The spontaneous electrical and mechanical activities of isolated vascular smooth muscles in rats.


Two large infant autopsy cases.

Two large infant autopsy cases.


Three autopsy cases of cebocephalus.

Three autopsy cases of cebocephalus.


Distribution of fatty acids in the plasma lipids of herbivores grazing pasture: a species comparison.


The hemoglobin of amphibia. X. Sedimentation behaviour of frog, triton and axolotl hemoglobins.


Catabolic pathways for glucose in the cichlid fish, Cichlasoma bimaculatum.


Phosphoglucomutase polymorphism in sockeye salmon.


Serum esterases of Equidae: truly or apparently negative phenotypes.


Measurement of corticosteroids in reptilian and avian plasma by fluorometry and by competitive protein-binding radioassay.


The utilization of reserves during starvation of larvae of the migratory locust.


Temperature-and-light-mediated alterations of ATP level in the chick embryo in egg; and their role in morphogenesis.


Further studies of transferrins of the arctic ground squirrel Spermophilus undulatus (rodentia: sciuridae).


Pigment polymorphism and blood serum variations in Rana pipiens.


Glucocorticoids and cellular immunity in vitro. Facilitation of the sensitization phase and inhibition of the effector phase of a lymphocyte anti-fibroblast reaction. We studied the influence of glucocorticoids on the sensitization phase as well as on the cytolytic effector phase of an in vitro lymphocyte-mediated immune reaction. Lymphocytes obtained from the spleens or lymph nodes of unimmunized inbred rats were sensitized against foreign rat or mouse embryonic fibroblasts in cell culture. The capacity of the sensitized lymphocytes to produce a cytolytic effect was tested by transferring them to target fibroblast cultures. Injury to target fibroblasts was measured by release of radioactive (51)Cr from previously labeled fibroblasts or by direct count of viable fibroblasts after incubation with sensitized lymphocytes. Various concentrations of water-soluble hydrocortisone or prednisolone were added to cell cultures during the 5 day sensitization phase and/or during the subsequent cytolytic effector phase and the influence of these hormones on the number and cytolytic capacity of the lymphocytes was measured. During the sensitization phase, the presence of glucocorticoid hormones, at concentrations of about 1 microg/ml, led to a profound decrease in the total number of recoverable lymphocytes. However, the per cent of large transformed lymphocytes was much greater in these treated cultures. The antigen-specific cytolytic capacity per cell of the glucocorticoid-treated lymphocytes, after the hormone was removed, was several times greater than that of lymphocytes sensitized in the absence of added hormones. Glucocorticoids influenced the effector phase of the reaction by inhibiting lymphocyte-mediated injury to target fibroblasts. The hormones, at concentrations of about 1 microg/ml, inhibited the cytolytic effect by about 50% without reducing the viability of the sensitized lymphocytes. Dose-dependent toxicity to lymphocytes and increasing inhibition of cytolytic effect appeared at higher concentrations of hormones. Thus, hydrocortisone and prednisolone, at concentrations of about 1 microg/ml, did not suppress the induction of sensitization, a process which they seem to facilitate in vitro. However, similar concentrations of these hormones appear to inhibit the cytolytic effector mechanism of sensitized lymphocytes. These findings may be relevant to the use of glucocorticoids as immunosuppressive agents in vivo.


Action of diphtheria toxin in the guinea pig. The blood clearance and distribution in the tissues of (125)I after intravenous injection of small doses (1.5-5 MLD or 0.08-0.25 microg) of (125)I-labeled diphtheria toxin has been followed in guinea pigs and rabbits and compared with the fate of equivalent amounts of injected (125)I-labeled toxoid and bovine serum albumin. Toxoid disappeared most rapidly from the blood stream and label accumulated and was retained in liver, spleen, and especially in kidney. Both toxin and BSA behaved differently. Label was found widely distributed among all the organs except the nervous system and its rate of disappearance from the tissues paralleled its disappearance from the circulation. There was no evidence for any particular affinity of toxin for muscle tissue or for a "target" organ. Previous reports by others that toxin causes specific and selective impairment of protein synthesis in muscle tissue were not confirmed. On the contrary, both in guinea pigs and rabbits, a reduced rate of protein synthesis was observed in all tissues that had taken up the toxin label. In tissues removed from intoxicated animals of both species there was an associated reduction in aminoacyl transferase 2 content. It is concluded that the primary action of diphtheria toxin in the living animal is to effect the inactivation of aminoacyl transferase 2. The resulting inhibition in rate of protein synthesis leads to morphologic damage in all tissues reached by the toxin and ultimately to death of the animal.


An ultrastructural study of glomerular permeability using catalase and peroxidase as tracer proteins. Mice were injected intravenously with beef liver catalase (mol wt 240,000) and very small doses of horseradish peroxidase (mol wt 40,000) and the site of localization of these enzymes in the kidney was studied by ultrastructural cytochemistry. 1 min after injection, catalase was present in glomerular capillary lumina and there was minimal permeation of the basement membrane. After 5-180 min, staining of the basement membrane increased progressively but was usually less than that in capillary lumina. At all time intervals the inner (sub-endothelial) layer of the basement membrane contained more reaction product than the lamina densa and the outer (subepithelial) layer. Catalase permeated the entire thickness of the basement membrane and extended up to the slit pore but not beyond the level of the slit diaphragm and was not seen in the urinary space or tubular lumina. Horseradish peroxidase permeated the whole thickness of the basement membrane within 2 min after injection; however, gradients of staining from the inner to outer layers of the basement membrane were frequently seen. The findings with both enzymes indicate that (a) the basement membrane restricts the passage of proteins over a wide range of molecular size with increasing impediment for larger molecules and (b) the slit pore functions as an additional barrier for molecules that cross the basement membrane.


An ultrastructural study of glomerular permeability in aminonucleoside nephrosis using catalase as a tracer protein. Beef liver catalase (mol wt 240,000) was injected intravenously into normal rats and rats made nephrotic with aminonucleoside of puromycin. The localization of the tracer in the kidneys was then studied by ultrastructural cytochemistry, 3 min-12 hr after injection. Passage of catalase into the urinary space in normal rats was restricted by the basement membrane and by the epithelial slit pore. Nephrotic glomeruli showed extensive fusion of foot processes and formation of pockets and vacuoles in the fused epithelium; within 3 min after injection, catalase appeared in basal pockets, epithelial vacuoles, and the urinary space. Residual slit pores and close junctions in fused epithelium were impermeable to catalase. These studies indicate that alteration of the epithelial cells and basement membrane is responsible for protein leakage in aminonucleoside nephrosis.


The interaction between human monocytes and red cells. Specificity for IgG subclasses and IgG fragments. Studies were carried out in order to characterize the specificity of IgG sub-classes and IgG fragments for rosette formation using red cells and human mononuclear cells. Rosette formation of red cells coated with anti-D was inhibited by free IgG(1) and IgG(3); less inhibition occurred with IgG(2) and IgG(4). Red cells specifically coated with IgG(1) and IgG(3) by chromic chloride were bound to monocytes. Rosette inhibition of anti-D-coated red cells occurred with free Fc fragment of IgG globulin, and only partly with F(ab')(2). Inhibitory capacity of Fc fragments of IgG and gamma(1) heavy chain from heavy chain disease was reversed by the cleavage of disulfide bonds. No inhibition was noted with Fab, or with pepsin components II, III, or IV. These studies indicated that the mononuclear receptor was specific for IgG(1) and IgG(3). The peptide portion of IgG globulin which attached to the mononuclear cell appeared to reside in the N-terminal portion of the Fc fragment and also appeared to require the integrity of the inter-heavy chain disulfide bond. A specific receptor for C3 was not confirmed.


Studies on the differentiation of thymus-derived lymphocytes. The development pathway from embryonic thymus-stem cell to peripheral thymus-derived lymphocyte has been demonstrated using the alloantigens theta (theta) and TL as surface markers of cell differentiation. On the basis of cytotoxicity tests carried out on CBA.H or A embryo thymus cultured in diffusion chambers and on CBA.H embryo thymus grafts and peripheral lymphocytes derived from them in AKR hosts, it has been concluded that two differentiation stages take place during the maturation of thymus-derived cells, namely a first step from stem cell to thymocyte and a second step from thymocyte to peripheral lymphocyte.


Histocompatibility type and immune responsiveness in random bred Hartley strain guinea pigs. Outbred Hartley strain guinea pigs capable of responding immunologically to 2,4-dinitrophenylated poly-L-lysine were shown to display a histocompatibility specificity in common with inbred strain 2 guinea pigs. This histocompatibility specificity was not detected in guinea pigs unable to respond immunologically to DNP-PLL. The result suggests that the poly-L-lysine specific immune response gene is very closely linked or even identical with a gene determining a major histocompatibility antigen in guinea pigs.


Regulation of antibody formation by serum antibody. II. Removal of specific antibody by means of exchange transfusion. Rabbits were immunized to two antigens and 18-55 days later exchange transfusion was performed using blood of rabbits immunized to one antigen only. By this means, serum antibody levels to one antigen were reduced 50-84% while maintaining serum antibody levels to the second antigen. After exchange, serum antibody levels of the removed antibody rose rapidly for 24-48 hr and then more slowly, reaching peak titers an average of 8 days later. The peak titer was 48-222% higher than the preexchange titer. The specificity of this rebound excluded as a cause nonspecific changes in Ig levels. Passive administration of antibody to a third antigen 4-7 days before the exchange indicated that re-equilibration of preformed antibody was not a major factor in the rebound. A change in the ratio of IgM to IgG antibodies as a cause of an increased neutralization titer in the postexchange sera was also excluded. It was therefore suggested that a change in the rate of antibody formation had occurred, although other changes in the quality of serum antibody were not excluded.


Geographic and secular variation in mortality from malignant disease in Oklahoma 1956-1965. 3. Cancer of the gastrointestinal tract.


Mechanism of action of dopamine in endotoxin shock.


The pathology, diagnosis and medical-legal aspects of death by drowning.


Chickenpox confused with smallpox. Case report.


Comparative studies of vaccines against rubella.


Newer concepts of hemiplegia.

Newer concepts of hemiplegia.


Tumor clinic proceedings. Case no. 25. Rhabdomyosarcoma of the deltoid muscle.


Renal artery aneurysm. Report of a case with associated hypertension.


Role of the veins in shock.

Role of the veins in shock.


Tumor clinic proceedings. Case no. 26. Hodgkin's disease.


Treatment of burns of the hands.

Treatment of burns of the hands.


Studies of the rubella syndrome.

Studies of the rubella syndrome.


Exudative enteropathy.

Exudative enteropathy.


Gastrointestinal hormones.

Gastrointestinal hormones.


Tumor clinic proceedings. Case no. 27. Squamous cell carcinoma metastatic to the cervical lymph nodes.


Regional medical programs and medical care in rural Oklahoma.


Mammography in daily practice.

Mammography in daily practice.


Defective iodide organification in "cryptothyroidism".


Tumor clinic proceedings. Case no. 28. Squamous cell carcinoma of the larynx.


Clinical references in pulmonary disease.


Forward together.

Forward together.


Clinical-metabolic study of the Prader-Willi syndrome.


Clinical pharmacologic studies in infants and children.


New chromosomal abnormalities.

New chromosomal abnormalities.


Proficiency testing in Oklahoma physicians' office laboratories.


Universal health insurance.

Universal health insurance.


Correlative study of renal function and serial urine osmolalities following 14-hour fluid deprivation.


Clinical references in oncology.

Clinical references in oncology.


Tearing and smog.

Tearing and smog.


Government and voluntary agencies in vision research.


Why people fail appointments.

Why people fail appointments.


Prevention of blindness: chronic glaucoma.


Brightness dependence of colour preferences in herring gull chicks.


Polarization optical investigations on the adductors of pelecypods (mollusca).


Physiological and morphological evidences of the intramuscular regulation of rhythmic activity in the adductors of Anodonta cygnea L.


Priority setting for R&D at the national level.


Left ventricular tissue pressure in the dog.


Quantitative determinations by ion pair extraction. 6. Principles for determination of extraction constants.


Biosynthesis of mescaline and 3,4-dimethoxyphenethylamine in Trichocereus pachanoi Br&R.


Quantitative gas chromatographic determination of nanogram levels of desipramine in serum.


Fluorimetric determination of pentazocine in biological samples by partition chromatography as ion pair in micro-columns.


Photometric determination of anions with the use of tetrahexylammonium picrate as a liquid anion exchanger.


Rheological properties of the liquid crystalline phase of monocaprylin and water and the effect of solubilized tricaprylin.


Gas chromatographic determination of 7-(beta-hydroxypropyl) theophylline in biological fluids.


Directed-experience hypnosis.

Directed-experience hypnosis.


Influence of adrenaline on the splitting of glycogen and maltose by gamma-amylase of liver, heart and skeletal muscles of the rat.


Further studies on the effects of various in vivo and in vitro factors on the priming and template activities of DNA isolates in the DNA and RNA polymerase systems.


The cerebrosides of bovine heart muscle.


Chemistry of glycosphingolipids Fabry's disease.


The interaction of cholesterol with the sterol free lipids of plasma membranes.


A plasticizer in lipid extracts of human blood.


LSD: chromosomal breaks in Antheraea eucalypti (Scott) (Lepidoptera: Saturniidae).


Stuttering and cluttering. The differential diagnosis.


Cluttering.

Cluttering.


Crohn's disease of the stomach and duodenum. Clinical and radiological abnormalities in 12 patients with gastroduodenal involvement were encountered amongst 300 patients followed by one of us between 1944 and 1969. Symptoms of dyspepsia were relatively mild and obstructive symptoms when present were readily relieved by bypass surgery. The patients have been followed for a mean of 9.7 years (range 1-20); two have died of other causes but the remaining 10 are well.


A new method of measuring the rate of shedding of epithelial cells from the intestinal villus of the rat. Epithelial cells shed from the intestinal villus in starved rats were trapped in mucus which the goblet cells were stimulated to secrete; the number of trapped cells per villus was counted in whole mounts of fixed Feulgen-stained specimens from three sites in the small intestine. Increase in the interval between stimulation and fixation caused an increase in the number of shed cells per villus; the rate of this increase was postulated to represent the rate of cell shedding. The rate of cell production per crypt was measured with Colcemid; this rate, multiplied by the number of crypts per villus, gave the rate of cell production per villus. There was good agreement between these estimates of cell production and cell shedding.


Electron microscopy of myenteric nevrves in Hirschsprung's disease and in normal bowel. The ultrastructure of the myenteric nerves of colon and rectum removed from 10 children with Hirschsprung's disease has been studied and compared with normal infant bowel. Distal aganglionic (Hirschsprung) bowel often showed a rich supply of nerves within the muscle layers and there was no obvious morphological abnormality of constituent axons. The numbers of nerves diminished as more proximal parts of the bowel were examined and the fewest nerves were found where ganglia first appeared. These ganglia were similar in structure to the ganglia of normal bowel, and a striking feature of them all was the absence of collagen between constituent neuronal units. The larger nerve trunks of aganglionic bowel frequently contained myelinated axons and these have been observed within the myenteric plexus of normal rectum. This study supports previous histochemical investigations of the nerves in bowel from patients with Hirschsprung's disease and indicates that the condition is due to a complex and variable abnormality of the arrangement of the nervous tissue of the bowel wall, involving myenteric nerves as well as ganglia.


The use of gastric function tests by members of the British Society of Gastroenterology.


Effect of luminal pH on intestinal absorption of water and electrolytes.


Occurrence of an abnormal lipoprotein in patients with liver disease. An abnormal lipoprotein, containing a high proportion of unesterified cholesterol and phospholipid, has previously been described as occurring in the serum of patients with obstructive jaundice, and has been called lipoprotein X. Using an immunoelectrophoretic method for the detection of lipoprotein X in serum, the sera of 97 patients with liver disease have been screened and the associated biochemical features measured.Lipoprotein X was found in 45% of cases of liver disease with cholestatic features, and was not detected in cases of liver disease without cholestasis. The incidence of lipoprotein X in different causes of cholestatis varied, and while it was commonest in cases of extrahepatic obstruction of recent onset, occurring in 75% of cases, it was also found in primary biliary cirrhosis in 48% of cases, and in cholestatic hepatitis, less commonly.The cause of the appearance of lipoprotein X is unknown, but analysis of associated biochemical features suggested a relationship to physical biliary obstruction rather than a derangement of liver cell function.


Sodium, potassium, and water absorption by normal human rectum.


Spontaneous duodeno-colic fistula.

Spontaneous duodeno-colic fistula.


Studies on bidirectional sodium fluxes across the intestinal mucosa in cholera patients.


The influence of sex, body weight, and renal function on the xylose test. A low excretion of xylose may be due to malabsorption, renal disease, or old age. Malabsorption can be distinguished from other causes by performing a combined oral and intravenous test, the result being expressed as a fraction of these readings. Sex and body weight do not influence the xylose test.


Gallbladder inertia in adult coeliac disease.


Immunoloiical studies of a community outbreak of hepatitis.


The relationship of gastric secretion to anemia over 15 years following vagotomy and gastroenterostomy.


75Se activity in the duodenal test meal aspirate: a new pancreatic function test.


Diagnosis and prognosis of primary malignant tumors of the liver.


The pathogenesis of coeliac disease.

The pathogenesis of coeliac disease.


Small bowel permeability in animals and man.


The amino acids and Paneth cells of the small intestine.


The localization of enterokinase to the brush border membrane of the guinea pig small intestine.


An experimental model of human chronic pancreatitis.


Acalculous adenomyomatosis of the gallbladder. The course of acalculous adenomyomatosis of the gallbladder in six patients is described. It is suggested that, even in the absence of gallstones, cholecystectomy should be advised when this condition is demonstrated radiographically in symptomatic subjects. The cause of the pain is unknown but it is probably related to excessive neuromuscular activity of the hyperplastic gallbladder wall. One of the patients was found also to have an adenomatous polyp containing areas of adenocarcinoma. Although this polyp was not situated within an area of adenomyomatosis, it is possible that, as in most other patients with carcinoma of the gallbladder, previous disease may have predisposed to malignant change.


The role of serum trypsin inhibitors in acute pancreatitis.


An endocrine tumour in kidney affecting small bowel structure, motility, and function.


Inactivation of gastric and pentagastrin in the portal circulation.


The effect of protein, carbohydrate, or fat on plasma gastrin concentration in human subjects.


Reduction in mucosal blood flow as a factor in the decreased response to gastrin after vagotomy.


Recurrent ulcer and postvagotomy gastric acid secretion.


The effect of vagotomy on the intestinal transport of water and electrolytes.


110 highly selective vagotomies without drainage (HSV) for duodenal ulcer.


Evaluation of a Bayesian model in the diagnosis of jaundice.


Bile salt metabolism in the normal human small intestine.


Absorption of bile acids by the colon.

Absorption of bile acids by the colon.


Inhibitory effect of neomycin on cholesterol absorption in germ-free pigs.


Absorption of tritiated vitamin K1 in patients with fat malabsorption.


Mannitol utilization in the stagnant loop syndrome.


Familial steatorrhoea with calcification of the basal ganglia and mental retardation.


Osteomalacia in adult coeliac disease.

Osteomalacia in adult coeliac disease.


The mucosal contribution to non-dietary lipid in the intestinal lumen.


Mucosal abnormalities and disaccharidases in pernicious anemia.


The fate of ileorectal anastomosis in Crohn's disease of the large bowel.


Coeliac disease, vasculitis, and cryoglobulinaemia.


Hereditary angioneurotic oedema: an unusual cause of recurring abdominal pain. Two patients with hereditary angioneurotic oedema, a condition characterized by repeated episodes of abdominal pain and oedema, and by an absence of complement-1 esterase inhibitor activity in the plasma are presented in detail. Both underwent multiple surgical procedures before the diagnosis was established. Abdominal pain is often the presenting complaint, and although a complete history will usually lead to the proper diagnosis, cases in which the family history is not clear can present a diagnostic dilemma. Characteristic radiological demonstration of localized intestinal oedema will only be obtained if studies are performed early during the acute attack.


Studies of the effect of metoclopramide and apomorphine on gastric emptying and secretion in man. With oral and intravenous doses of metoclopramide there was no constant effect on the gastric emptying of test meals of glucose or sodium citrate, nor was secretion of acid by the stomach in response to test meals of glucose or sodium citrate affected. Apomorphine, in subnauseous doses (0.25 mg intravenously) slowed the gastric emptying of test meals containing sodium citrate, and 10 mg of intravenous metoclopramide abolished the slowing of gastric emptying caused by apomorphine.


Observations on gastric acid output by a three-hour histamine infusion test using maximal doses on patients with duodenal ulcer and in normal controls. The results of a series of histamine infusion tests extended over a period of three hours in 100 patients with duodenal ulcer and in 30 normal controls showed that while in the former group acid secretion continued to rise hourly both quantitatively and qualitatively throughout each of the three-hour periods of the tests, this did not occur in the normal controls in whom acid secretion levelled off during the second hour. Assay of 30-minute aspirates in the duodenal ulcer group showed that the 90-120 minute specimen (doubled) gave a close approximation to the values obtained during the third hour and represents maximal acid secretion of the gastric mucosa.


Peptic ulceration in Crohn's disease (reional enteritis). The incidence of peptic ulceration in a personal series of 300 patients with Crohn's disease was 8%. Resection of 60 or more centimetres of the small intestine was associated with significantly increased acid output, both basally and following pentagastrin stimulation. Only five (4%) of the 124 patients who received steroid steroid therapy developed peptic ulceration. It is suggested that resection of the distal small bowel may be a factor in the probable increase of peptic ulceration in Crohn's disease.


The functions of 'inner objects'.

The functions of 'inner objects'.


Time course of the sodium influx in squid giant axon during a single voltage clamp pulse. 1. Sodium influx measurements were carried out on internally perfused squid giant axons under conditions of membrane potential control.2. The ratio ;measured extra sodium influx/calculated ionic influx from the inward current record' is close to unity and is independent of the duration of the rectangular pulse of membrane potential.3. The variation of the sodium permeability with time during the voltage clamp pulse is obtained by subtracting the sodium influx obtained from the ;tail' current record from the measured extra sodium influx.4. Evidence was obtained indicating that the measured change in sodium permeability during a sudden decrease of the membrane potential from its resting level involves two processes, namely, a transient increase in sodium permeability (activation), and a decrease in sodium permeability (inactivation).5. The extra influx of sodium during a voltage clamp pulse is not decreased by raising the internal sodium concentration from 0 to 100 mM, supporting the validity of the independence principle.


The cooling of rats and their recovery from deep hypothermia.


An electron microscopic study of the human fetus cochlea.


Adipose tissue in the new-born goat.

Adipose tissue in the new-born goat.


Research.

Research.


Medical ideology: a problem of survival.


General practice in a developing society.


Handwriting as an objective test of performance ability.


Eisenmenger--V.S.D.--a study of congenital and acquired pulmonaryvascular disease.


"Attempted suicides".

"Attempted suicides".


A review of recent supracondylar fractures of the humerus in children.


A study of 100 schizophrenic patients in private practice.


A case of clonorchis infection in Singapore--clinical and pathological features.


Prevalence and intensity of helminthic infections in adults among the ethnic groups in Singapore.


Small intestinal absorption studies and biopsy findings in Asians, in Singapore.


The effects of age, education and occupational on psychiatric dispositions.


Non-medical interventions in life and death.


Projects under way.

Projects under way.


The escape of the renal blood flow response during sympathetic nerve stimulation.


Disseminated intravascular coagulation associated with low factor VII. Evidence for a new type of hemostatic disorder.


A simple technic for semiquantitative, clinical estimation of serum beta- and pre-beta-lipoproteins.


Blood fibrinolytic activity in young Britons, Africans and Asians in relation to their 'weight-for-height' standard.


The role and significance of vasodilatation in the development of small arterial lesions in the rat.


Severe segmental obstruction of the left main coronary artery and its divisions. Surgical treatment by the saphenous vein graft technique.


Ascending aorta-to-coronary artery saphenous vein bypass grafts.


The physiologic parameters of ventricular function as affected by direct coronary surgery.


Complete surgical correction of the totally occluded and diffusely diseased right coronary artery.


Correlation of mean pulmonary arterial pressure with results of surgery for nonrestrictive ventricular septal defects.


Arterial and venous microsurgical bypass grafts for coronary artery disease.


Late cardiodynamics following correction of ventricular septal defects with previous pulmonary artery banding.


Cor triatriatum. Clinical presentation and operative treatment.


Study of the mechanisms of shunt failure after superior vena cava-right pulmonary artery anastomosis.


Prosthetic valve endocarditis.

Prosthetic valve endocarditis.


Experimental production of chronic graded mitral valve stenosis.


Clinical use of a dacron wool filter during perfusion for open-heart surgery.


Experimental polycythemia and hemodilution. Physiologic and rheologic effects.


Benign tumors of the lung. A ten-year surgical experience.


Decortication for trapped lung in the newborn infant.


Cardiac wounds at a military evacuation hospital in Vietnam. A review of one year's experience.


Rearrangements between germ-line limited and somatic chromosomes in Smittia parthenogenetica (Chironomidae, Diptera).


Repeated sequences in the DNA of Drosophila and their localization in giant chromosomes.


Evaluation of the patient with dysphagia.


Determination of acid sensitivity, mucosal damage and esophagitis.


Management of gastroesophageal reflux.

Management of gastroesophageal reflux.


Surgical management of esophageal reflux and hiatal hernia.


Management of a lower esophageal ring.

Management of a lower esophageal ring.


Evaluation of the patient with chest pain.


Pathophysiology and management of acute corrosive burns of the esophagus.


Dilatation of esophageal strictures.

Dilatation of esophageal strictures.


Treatment of achalasia with pneumatic dilatation.


Surgical treatment of achalasia.

Surgical treatment of achalasia.


Esophageal moniliasis.

Esophageal moniliasis.


Esophageal perforation.

Esophageal perforation.


Management of foreign bodies in the esophagus.


Antidotal properties of activated charcoal.


Chilling temperature depression of isocitratase activity from cotyledons of germinating cotton.


The origin of the genetic code.

The origin of the genetic code.


An ATP dependent reduction of nitrate to ammonia by a cell free particulate system from barley roots.


Organic phosphates and ligand binding in hemoglobin.


The release of 45Ca from mitochondria of chicken intestinal mucosa by calcium binding protein.


Cofactor transfer from cystathionase to aspartate aminotransferase.


Chemical characterization of two urinary sialic acid-rich glycopeptides.


Chemical characterization of cytochrome P-450cam.


Effect of size on the relative rate of degradation of rat liver soluble proteins.


Inhibition of yeast thiaminephosphate pyrophosphorylase by high-energy phosphate compounds.


The purification of a soluble cytochrome from pig kidney with spectral properties similar to those of microsomal cytochrome b5.


Ribosomal subunits from rat liver. Isolation and recombination into active ribosomal particles.


Assay of brain particulate neuraminidase. II. Identification of the endogenous substrates of the enzyme.


Assay of brain particulate neuraminidase. I. Determination of N-acetylneuraminic acid released by the enzyme from endogenous substrates.


Cranio-cerebro-cervical injuries.

Cranio-cerebro-cervical injuries.


On the occurrence of Mycoplasma hyorhinis in the respiratory organs of pigs, with special reference to enzootic pneumonia.


Persistence and excretion of Treponema anserinum (Sakharoff, 1891) in hens.


Effects of dextranase on experimental caries in the rat.


The concept of prevention.

The concept of prevention.


A regression analysis on the mortality of the Hiroshima atomic bomb survivors.


Effect of grass maturity stage in dry cows. 3. The fate of mineral elements.


Standardization in phonocardiography: the microphone pickup.


Some thoughts concerning the nomenclature of A-V nodal arrhythmias.


Neonatal surgery at White Memorial Medical Center 1950-68.


The therapeutic use of self.

The therapeutic use of self.


Transfaunation studies with germ-free Mus musculus using the Entamoeba from three rodent species.


Auto-analyzer versus Folin-Wu for blood glucose.


The use of linkage in genetic counselling.


A contribution to the genetics of hypertrichosis of the ear rims.


Genetical and developmental aspects of susceptibility to motion sickness and frost-bite.


The world distribution of electrophoretic variants of the red cell enzyme adenylate kinase (ATP:AMP phosphotransferase)EC 2.7.4.3.


Relation between the pregnancy zone protein and fetal sex.


Studies on the haptoglobin system. I. The distribution of Hp groups in the Swedish population.


Studies on the haptoglobin system. II. The development and distribution of Hp groups in children.


Chemical mutagenesis comes of age: environmental implications.


Biochemical parameters of clinical significance in rabbits. I. Strain variations.


Biochemical parameters of clinical significance in rabbits. II. Diurnal variations.


Chromosomes of mammary carcinomas induced by 3-methylcholanthrene in rats.


Correlation of conduction velocity and O 2  consumption rate in frog sciatic nerve.


Chromosome phylogeny of Drosophila pachea and related species.


Bradykinin and gastric secretion.

Bradykinin and gastric secretion.


Cerebrospinal fluid and blood catecholamines in chronic diffuse glomerulonephritis.


Linkage of esterase-3 and rex on linkage group VII of the mouse.


Cuna Moon-child albinism, 1950-1970.

Cuna Moon-child albinism, 1950-1970.


Hemolysis of human erythrocytes by lipid peroxides and fatty acids.


Genetic basis for plumage color pattern in the New Hampshire fowl.


LSD and plant chromosomes.

LSD and plant chromosomes.


[Submicroscopic structure of the iris tissues examined in polarized light].


Topological classification of palmar dermatoglyphics.


Comparative study of sole patterns in chromosomal abnormalities.


Mosaic XXX-XXXX sex chromosome complement. Case report and review of literature.


Influence of external incentives on motor performance of institutionalized retardates.


Ammonium chloride as an adjuvant to diphenyl-hydantoin therapy, and bulk ions in the CSF and serum in forty mentally subnormal epileptics.


Eleven new cases of aspartylglucosaminuria.


Ring chromosome 18 in a mentally retarded boy.


Some experiences on pyelonephritis.

Some experiences on pyelonephritis.


[Arachnoidal cyst of the Sylvian fissure].


Why are sloths so slothful?

Why are sloths so slothful?


Three dimensional radiography.

Three dimensional radiography.


Human zinc deficiency.

Human zinc deficiency.


A microradiographic study of bone disease in uremia.


Results of screening patients for peripheral vascular disease by paramedical personnel.


Emergency surgical treatment of bleeding peptic ulcer: an analysis of the published data on 21,130 patients.


Medical education--a three legged stool.


[A new x-ray method in the surgery for kidney calculi].


The founder effect and response to artificial selection.


Genetic aspects of fertility and endocrine organ size in rats.


Selection for the length of the spermatozoan midpiece in the mouse.


Genetic variation in the eel. II. Transferrins, haemoglobins and esterases in the eastern North Atlantic. Possible interpretations of phenotypic frequency differences.


A new class of slow-growing non-perithecial mutants of Aspergillus nidulans.


Controlling elements in the mouse X-chromosome. 3. Influence upon both parts of an X divided by rearrangement.


A variegated position effect in Aspergillus nidulans.


The tolerance of aneuploidy in yeast.

The tolerance of aneuploidy in yeast.


Genetic evidence of an unorthodox chromosomal system in the lac insect Kerria lacca (Kerr).


Chromosomal analysis of cultured skin fibroblasts from patients with infectious mononucleosis.


Disturbed segregation at the transferrin locus of the deer mouse.


Pseudomonas cepacia from blood of a burn patient.


Colporectocystogram with pneumoperitoneum in cases of tumours of the small pelvis.


Some efferent connections of the magnocellular nucleus of medial geniculate body in the cat; with sp;ecial reference to the pain conducting pathway.


Reconstructive surgery of the middle ear by homografts.


Specific action of some drugs on Bechterew nystagmus.


Models of the processing of quantum signals by the human peripheral retina.


Models of retinal signal processing at high luminances.


Haemagglutination and haemagglutination-inhibition reactions of extracts from snails and sponges. I. Agglutination of human and various animal red cells: its inhibition by sugars and aminosugars.


Polymers in preparation of human serum albumin.


Auto-donation in the management of placenta previa and erythroblastosis in a pregnancy complicated by Gerbich iso-immunization.


Visceral larva migrans in dogs.

Visceral larva migrans in dogs.


The Humpty Dumpty phenomenon.

The Humpty Dumpty phenomenon.


Dimensions of anesthetic uptake.

Dimensions of anesthetic uptake.


The effects of CO2 and systemic hypertension on cerebral perfusion pressure during carotid endarectomy.


The relationship between myocardial function and glucose metabolism in the halothane-depressed heart. I. The effect of hyperglycemia.


Intrathoracic pressure, pulmonary vascular pressures and gas exchange during pulmonary lavage.


The relationship between myocardial function and glucose metabolism in the halothane-depressed heart. II. The effect of insulin.


The interaction of d-tubocurarine with antiarrhythmic drugs.


A nonlinear model for the uptake and distribution of halothane in man.


The effect of gas inflow on the regulation of CO2 levels with hyperventilation during anesthesia.


The effects of anesthesia and hypothermia on canine cerebral ATP and lactate during anoxia produced by decapitation.


A new concept for the continuous monitoring of anesthetic gases. I. Detector theory and clinical uses.


A new concept for the continuous monitoring of anesthetic gases. II. Halothane: comparison of various vaporizers' outputs.


A new and simple method for ventilating patients undergoing bronchoscopy.


A method for supplemental oxygen administration during weaning from mechanical ventilation.


A method of fixation of nasotracheal tubes in infants.


An anesthetic tubing support.

An anesthetic tubing support.


Note on endotracheal tubes.

Note on endotracheal tubes.


A report on a possible hazard of gas cylinder tanks.


The improperly calibrated flowmeter--another hazard.


On the potential for genetic variability in haplo-diploidy.


The nuclear division and parasexual cycle in Penicillium.


Recombination and transcription in the hisB and paba1 loci of Aspergillus nidulans.


Recessive genetic variants affecting mating activity of males in natural populations of Drosophila melanogaster.


An analysis of white-mottled mutants in Drosophila hydei, with observations on X-Y exchanges in the male.


A linkage test with satin in the rabbit.


Genetic and morphological properties of undifferentiated and invasive variants of Aspergillus nidulans.


New crisp genes and crisp-modifiers in neurospora crassa.


The relation of mitotic recombination to DNA replication in yeast pedigrees.


Organellar damage and revision as a possible basis for intraclonal variation in paramecium.


Gene conversion in higher organisms: half-tetrad analysis of recombination within the rosy cistron of Drosophila melanogaster.


Parthenogenesis and genetic variability. I. Linkage and inbreeding estimations in the frog, Rana pipiens.


Parthenogenesis and genetic variability. II. One-locus models for various diploid populations.


On the effects of genetic counselling on gene frequencies.


Genetic effects of fluctuating temperature in populations of Drosophila melanogaster.


Consanguinity in Ireland.

Consanguinity in Ireland.


Inbreeding and celibacy.

Inbreeding and celibacy.


Dermatoglyphics in congenital heart malformations.


Inheritance of asymmetry in finger ridge counts.


The distribution of some enzyme group systems among Marathis and Gujaratis in Bombay.


Sex and age relations of alkaline serum phosphatase phenotypes.


Alterations in human organ alkaline phosphatases during foetal development.


Haptoglobin and transferrin variants in two Congolese Bantu tribes.


The frequency of Fy a  and Fy b  antigens in the population of Budapest.


A computer based system of coding for genetic studies of large kindreds.


The relationship of figural after-effects and geometrical illusions to successive and simultaneous contrasts.


Alienation: another dimension of underachievement.


Behavioral reactions of Wistar rats to conditioned fear stimuli, novelty, and noxious stimulation.


Alternation of mood via music: a study of the vectoring effect.


Lysergic acid diethylamide (LSD 25): XXXIX. The effect of high temperatures on stability.


Random matrices and neural networks.

Random matrices and neural networks.


Dogmatism and divergent-convergent abilities.


Probabilistic analysis of dendritic branching patterns of cortical neurons.


Feedback regulation of the alpha electroencephalogram activity through control of the internal and external parameters.


A feature extractor for curvilinear patterns: a design suggested by the mammalian visual system.


The possibilities of neural holographic processes within the brain.


A milking system for the preparation of technetium-99m labelled tyrosine.


Studies of the influence of wavelength on biological effects. Time and dose differentials at "radiation action sites" in the skin.


The effect of radiophosphorus on the development of gonads in mice.


Lipid screening by thin layer chromatography.


Deviations of zygotic frequencies from expectations in eggs of Tribolium castaneum.


A mathematical model for recessive lethal segregation distorters with differential viabilities in the sexes.


Genetic alterations of the rII B cistron polypeptide of phage T4.


DNA hybridization in the genus Drosophila.


Selection in finite populations with multiple alleles. II. Centripetal selection, mutation, and isoallelic variation.


A population cage test for heterosis in Drosophila pseudoobscura.


Methodological and theoretical problems in the voluntary control of electroencephalographic occipital alpha by the subject.


Context-dependent stuttering.

Context-dependent stuttering.


Linearizing: a method for analysing and synthesizing nonlinear systems.


Automated health services--reprogramming the doctor.


The first decade of effort: progress toward a hospital information system at the UCLA Hospital, Los Angeles, California.


A model of a hospital's patient medical information system.


The potential of prepaid group practice in community medicine teaching programs.


Illegitimacy and race. National and local trends.


Attitudes toward marriage and family among black males in Tally's Corner.


Male use of contraception and attitudes toward abortion, Santiago, Chile, 1968.


The structure and change of mortality in a Maya community. This is the first known report on the demographic details of a Maya group.  The predominantly Maya town of Santiago Atitlan is in the Guatemalan highlands in the Department of Solola.  The town contains 2 distinct cultural groups, the Ladinos and Indians.  Ladinos is a term applied to persons whose style of life is not predominantly Indian.  They are 3.8% of the town's population.  Racial composition is unimportant.  The age and sex distribution is characterized by high birth and death rates.  The total fertility rate indicates that the average Atitlan family has 8 live births during its reproductive period.  There is little deliberate population control.  From 1960 to 1968 the crude death rate averaged 23 per 1000 population.  Previously it had been much higher.  In the 1960 decade the life expectancy at birth was 43.3 for males and 41 for females.  Female mortality in childbirth is believed to be the cause of their higher mortality in early life.  A higher mortality in later life, is not explained.  The infant and preschool age group contribute 50 to 70% of all deaths each year.  The effect of migration is negligible.  The population increase is 3% per year.  As most are subsistence farmers and a land shortage exists, problems are expected to develop.  A colonial record written in 1585 estimated that a larger population of about 12,000 had occupied the are before 1524.  By 1650 the population was about 1000 people.  An 1689 estimate was 2235 persons.  In 1770 the population was recorded as about 900.  Currently they are regaining their PreColumbian level with 10,462 people in 1964.  Present records of births, deaths, and population numbers are considered to be accurate.


Demographic profile of a Maya community. The Atitecos of Santiago Atitlán.


Fertility among urban blacks.

Fertility among urban blacks.


Contracepive practice among urban blacks in the United States, 1965.


Overview of demographic trends and characteristics by color.


Utilization of a family planning program by the poor population of a metropolitan area.


Community participation and control. A possible answer to racism in health.


Urbanization of the blacks.

Urbanization of the blacks.


Family planning in the Negro ghettos of Chicago.


Patterns of Negro-white residential segregation.


Mold allergy in otolaryngology.

Mold allergy in otolaryngology.


Contact lens fitting technique fall 1970.


Legislation on distinctions between optometry and ophthalmology.


Heredity of biological time and population genetics. Diabetes, lupus erythematosus, and peptic ulcer.


A new estimate of genetic load from inbreeding data.


The absence of one umbilical artery in malformed MZ twins.


Congenital coxa vara, patella aplasia and tarsal synostosis: a new inherited syndrome.


Malignant tumors among twins. A study of divergent views.


Amino acid incorporation by a cell-free preparation from rat adipose tissue. Effects of fasting.


Phosphate content of goose erythrocyte histones.


Gene action in the human haptoglobins. IV. Amino acid sequence studies on the haptoglobin alpha chains.


Aldolase activity in the cell-free extract of the protozoan Leishmania donovani.


Amino-terminal-blocked tripeptide analogues of the active site of  -chymotrypsin.


Relation of polysome structure to ribonuclease and ribonuclease inhibitor activities in livers of magnesium-deficient guinea pigs.


The influence of aminonucleoside on polysome patterns of rat liver.


Factors affecting protein synthesis in rat kidney ribosome preparations.


Gene action in the human haptoglobins. 3. Isolation of the alpha-chains as single gene products. Isolation, molecular weight, and amino acid composition of alpha and beta chains.


Two possible instances of hemoglobin E Saskatoon in Manitoba.


Arabinosyladenine and arabinosylhypoxanthine metabolism in murine tumor cells.


Nonsteady-state analysis of multisubstrate enzymic reactions.


The effect of cell-sap fractions on incorporation of amino acids into protein in rat liver cell-free systems.


Blood glucose levels and glucose tolerance in prediabetic and subclinical diabetic women on a low dose progestogen contraceptive.


Some reactions of sterculic and malvalic acids. A new source of malvalic acid.


Synthetic 1-thio- -D-glucosiduronic acids as substrates for rat-liver  -glucuronidase.


Spectrophotometric determination of gold in biological materials.


Examination of the mineral composition of the micelle of milk by gel filtration.


Combination chemotherapy: treatment of the Ehrlich ascites carcinoma and several drug-resistant sublines with combinations of 6-mercaptopurine and 6-(methylmercapto)purine ribonucleoside.


A study on the radioprotective property of thiourea against radiation-induced chromosome damage.


Effect of hypophysectomy on amino acid, thymidine, and orotic acid incorporation into the mucosa of the small bowel.


Scaling effects and the inheritance of juvenile body weight in chickens.


Studies on natural populations of Drosophila. XII. Heterosis and fitness characters in hybrids between different populations of Drosophila melanogaster.


Development, structure and composition of lampbrush chromosomes in domestic fowl.


The isolation of crossover suppressors on house fly autosomes and their possible use in isolating recessive genetic factors.


Estimation of the mitotic cycle in larval brain cells of the house fly.


Leaky mutation and coordinate regulation of the accumulation of lysine-precursors in Saccharomyces.


Centriole adjunct development in the cockroach, Eublaberus posticus.


Ethyl methanesulfonate-induced chlorophyll mutations in Triticum aestivum.


A suppressor of the heterokaryon-incompatibility associated with mating type in Neurospora crassa.


5-bromodeoxyuridine-induced constrictions in human chromosomes.


Ultraviolet light sensitive mutants of Ustilago violacea.


Omega-amino acids in rat brain.

Omega-amino acids in rat brain.


Relationships of the polytene chromosomes of Drosophila mediostriata and D. Griseolineata.


Incomplete synchrony of labelling in homologues of the autosomal pairs.


Half-chromatid aberrations and chromosome strandedness.


LSD induced genetic damage in barley.

LSD induced genetic damage in barley.


Diagnostic classification and nomenclature for existential state reactions.


Effects of progressive relaxation on autonomic processes.


Internal vs. external control, time perspective and delay of gratification of high and low ego strength groups.


The effect of auditory and visual stimulation on stereotyped rocking behavior and general activity of severe retardates.


Passage of inulin from mother to fetus as an unchanged polymer.


The relationship of minimal goal discrepancy to adjustment and anxiety in elementary school children.


Psychiatric symptomatology in transvestites.


Factors affecting choice of method of suicide.


Metabolic changes in experimental intrauterine growth retardation: blood glucose and liver glycogen in dysmature and premature newborn rats.


Defibrination following Echis colorata bite in man.


Reported frequency of dream recall as a function of intelligence and various personality test factors.


Feedback and experience effects on psychological reports and predictions of behavior.


Predicting WAIS IQ from Shipley-Hartford scores.


Factor analytic structure of the Wechsler adult intelligence scale in patients with diffuse and lateralized cerebral dysfunction.


Comparison of acetate and bicarbonate in the treatment of uremic acidosis.


Red blood cell potassium and serum potassium during open-heart surgery.


Laceration of the heart in a pregnant woman.


The correlation of Peabody picture vocabulary and Wechsler adult intelligence scale scores for adult psychiatric patients.


Some factors related to the selection of clinical psychology interns.


The B factor scale of the 16 PF as a measure of intelligence in psychiatric patients.


Further evidence concerning the diagnostic accuracy of the Halstead organic test battery.


Controlled elicitation and recording of proprioceptive reflexes.


Alcoholics' GATB and Shipley profiles and their interrelationships.


The Bender Gestalt test as an ineffective predictor of reading achievement.


Construction and evaluation of a test for measuring mania and depression.


An evaluation of an abbreviated form of the WISC.


Faking and faking detection on the personality research form, AA.


The 16 PF vs. the MCI in a group testing program of reformatory inmates.


Therapist focus on clients' significant others in psychotherapy.


Therapist's evaluative statements and patient outcome in psychotherapy.


Length of therapist response, accurate empathy and patient improvement.


Appraisal of a milieu therapy environment by treatment team and patients.


The effects of model reinforcement on emotionally disturbed adolescent boys.


Blood levels of ampicillin, kanamycin and gentamicin in the uremic patient.


Recent concepts of gallstone formation.

Recent concepts of gallstone formation.


Bone lesions in mild chronic bovine hypervitaminosis A.


The metabolism of ethylene dibromide in the rat: the enzymic reaction with glutathione in vitro and in vivo.


Antagonism of the anti-tumour effects of asparaginase by methotrexate.


Effect of phenobarbital pretreatment on the ability of aflatoxin B 1  to inhibit ribonucleic acid synthesis in rat liver.


Anti-inflammatory activity of thiamine and nicotinic acid.


Reinvestigation of methotrexate metabolism in rodents.


Antihemolytic actions of tricyclic tranquilizers. Structural correlations.


Inhibition of monoamine oxidation in brain by monoamine oxidase inhibitors.


Selective inhibition of monoamine oxidase in rat brain mitochondria.


Effects of benzoctamine (30803-Ba, TACITIN), a new psychoactive drug, on catecholamine metabolism.


The fertility of migrants to and within North America.


The population of Cambodia 1945--1980.

The population of Cambodia 1945--1980.


The effects of race and occupation on hypertension mortality.


Cervical cerclage in the treatment of incompetent cervix. A retrospective analysis of the indications and results of 164 operations.


Evidence for an ordered arrangement in erythrocyte membranes.


Photosynthetic carbon fixation by isolated maize chloroplasts.


In vitro protein synthesis in a mitochondrial fraction from HeLa cells: sensitivity to antibiotic and ethidium bromide.


Aspects of low-temperature-induced meiotic nondisjunction in Drosophila females.


Comments on the results of the preceding publication of Manigault concerning Agrobacterium tumefaciens M39 mutant.


Selective angiography of the left gastric artery.


Fused bifocal contact lenses.

Fused bifocal contact lenses.


Fitting with a corneal photograph.

Fitting with a corneal photograph.


Corneal topography and its application to contact lenses.


Contact lens wear and near visual discomfort.


Oral contraceptives and the contact lens wearer.


Clinical experiences with hydrophilic lenses at the London Refraction Hospital.


The design, production, and clinical technique of a modern contact lens--J-F perioptic aspheric lens.


Factors influencing corneal contact lens centration.


Insufficiency of the cervix uteri.

Insufficiency of the cervix uteri.


On the heredity of eye colour.

On the heredity of eye colour.


Mid-digital hair in the Czechoslovak population.


Connections of the subthalamus with the reticular formation of the rat brain stem.


The pressure in the occluded branch of the pulmonary artery and the "postarteriolar" vascular resistance.


Importance of pneumoradiography for diagnosing late stages of chronic pyelonephritis.


Treatment of advanced lower limb ischemias of arteriosclerotic origin by restorative arterial surgery.


Psychological observations on the artificial kidney unit's staff during dialysis treatment.


Analysis of osteoarticular changes in 104 acromegalic patients.


Changes in catecholamine levels during shock in man.


A study of intraoperative plasma expansion with a balanced electrolyte solution.


Bradycardia with carotid system infusions of cold blood during endarterectomy.


The anaesthetic management of posterior fossa explorations in infants.


The use of intravenous Diazepam (Valium) as a sedative and relaxant in urological endoscopic procedures.


Plasma levels of cortisol in man during spinal anaesthesia and surgery.


Plasma lidocaine concentrations following topical aerosol application to the trachea and bronchi.


The use of epinephrine in the presence of halothane in children.


The "analgizer" in a general hospital: a preliminary report.


Bronchial spasm during general anaesthesia.


Spleen reaction following tumor growth. A study with a homotransplantable rat tumor.


The digastric reflex in the kitten and adult cat: paradoxical amplitude fluctuations during sleep and wakefulness.


Inhibitory interactiions between thalaic VPL nuclei of the two sides.


Dynamic interactions in the retinal receptive fields and perceptual correlates.


Succinylcholine-induced antidromic motor nerve and extraocular muscle responses in the cat.


Perfusion chemotherapy for recurrent melanoma of extremity: a progress report.


Fine needle aspiration biopsy as an aid in diagnosis and therapy of renal carcinoma.


Radical mastectomy for carcinoma of the breast.


The surgical treatment of papillary thyroid carcinoma.


The identification of hot and cold thyroid lesions at operation and its place in the surgical management of carcinoma of the thyroid.


Influencing hormone inactivation by surgery.


International medical congresses: opportunities, purposes and responsibilites.


Average particle energy in beta decay.

Average particle energy in beta decay.


The metabolism of actinium in the rat.

The metabolism of actinium in the rat.


Thermally stimulated exoelectron emission, thermoluminescence, and impurities in LiF and BeO.


AERIN, a code for acute aerosol inhalation exposure calculations.


Medical radiation exposure survey in a hospital with a nuclear medicine laboratory.


Kinetics of lanthanum retention and tissue distribution in the Beagle dog following administration of  140 LaCl 3  by inhalation, gavage and injection.


Methods of localized irradiation of material by low energy or short range charged particles.


An inexpensive rf shield for use with radiation survey instruments.


Computer program for maintaining radioactive source inventories.


Fallout  90 Sr in beer.

Fallout  90 Sr in beer.


Rapid urine assay for tritium.

Rapid urine assay for tritium.


On the  -ray dose at the interface between two media.


Werner's syndrome.

Werner's syndrome.


Hemoglobin H disease. A case report.

Hemoglobin H disease. A case report.


Bone development, incidence of hypoglycemia and effect of maternal and fetal factors in low birth weight infants.


The incidence of the inability to smell solutions of potassium cyanide in the rural health center of Ortabereket.


Mirror movement. A case report.

Mirror movement. A case report.


Spastic diplegia following mediastinal neuroblastoma. A case report.


Prostatectomy cryotherapy compared with conventional methods.


Cryotherapy in urology.

Cryotherapy in urology.


Spontaneous reactivation of organophosphorus-inhibited electroplax cholinesterase in relation to acetylcholine-induced depolarization.


Studies on trimetoquinol. I. Distribution, excretion and metabolism of trimetoquinol.


Substrate supply and energy metabolism of skeletal muscle of mice treated with methamphetamine and propranolol.


Metabolism of acetanilides and anisoles with rat liver microsomes.


Mechanism of the gamma-hydroxybutyrate-induced increase in brain dopamine and its relationship to "sleep".


Apparent association of activity of anti-inflammatory drugs in a sulfhydryl exchange reaction in vitro and in the guinea pig erythema assay.


Formation and regional distribution of gamma-hydroxybutyric acid in mammalian brain.


Effect of desmethylimipramine, iprindole and DL-erythro-alpha-(3,4-dichlorophenyl)-beta-(t-butyl amino) propanol HC1 on the metabolism of amphetamine.


Effect of 2,4-dinitrophenol and other metabolic inhibitors on the renal deposition and excretion of mercury.


Studies on the metabolism of sulfametoxipirimidine in endotoxin induced stress.


Age and the sensitivity of chicks to the delayed neurotoxic effects on some organophosphorus compounds.


Effect of insulin on brain 5-hydroxytryptamine and 5-hydroxy-indole-acetic acid of rat.


Uterine transplantation in dogs.

Uterine transplantation in dogs.


Intracellular distribution of alkaline phosphatase in human placenta.


The Society for Gynecologic Investigation.


Thermoluminescence personnel dosimetry at Hanford. I.  7 LiF extremity and non-radiation worker dosimeters.


Contribution of activity released from protective clothing to air contamination measured by personal air samplers.


A portable area monitor for gamma-rays.

A portable area monitor for gamma-rays.


The energy-size dependence of the response of thermoluminescent dosimeters to photon irradiation.


Surgery for gigantic saccular postinfarction left ventricular aneurysms.


An experimental measurement of the high energy gamma rays produced by the slowing down of 14 MeV neutrons in air.


Fractionation properties of nuclear debris from the Chinese test of 24 December 1967.


Salvage of arteriosclerotic legs threatened by amputation.


An empirical model for estimating world-wide deposition from atmospheric nuclear detonations.


Cosmogenic and artificial Na-22 levels in rainwater.


Intermittent claudication of neurospinal origin.


[Aortopulmonary bypass with synthetic prosthesis in cyanotic heart defect patients].


A new device of membrane oxygenator.

A new device of membrane oxygenator.


Surgical treatment of trilogy and tetralogy of Fallot.


Clinical observations on postoperative hyperperfusion of the lungs in tetralogy of Fallot.


The hazards implication of the transfer of unsupported 210 Po from alkaline soil to plants.


A semi-empirical model for radionuclide transport in mammals.


Lead-210 in air and total diets in the United States during 1966.


Biological response to small discrete highly radioactive sources. II. Morphogenesis of microlesions in rat lungs from intravenously injected  238 PuO 2  microspheres.


Experience with boron-loaded nuclear track plates as detector elements for spherical moderator type neutron monitors.


Kinetics of lymph node activity accummulation from subcutaneous PuO 2  implants.


Sensitive automatic counting of alpha particle tracks in polymers and its applications in dosimetry.


Some tests on the consistency of the performance of six precision long counters intended as secondary standards for the measurement of fast neutron flux densities.


A portable electronic system equipped with an ionization chamber filled with a liquid equivalent to the biological tissue.


A sensitive ceramic BeO-TSEE-dosimeter.

A sensitive ceramic BeO-TSEE-dosimeter.


Hazards of tritium from controlled fusion.


Use of light source for testing thermoluminescent dosimeter readers.


Erosional behavior of Cesium-137.

Erosional behavior of Cesium-137.


Distribution of fallout and natural gamma radionuclides in litter, humus and surface mineral soil layers under natural vegetation in the Great Smoky Mountains, North Carolina-Tennessee.


Influence of salinity and temperature on the accumulation of cesium-137 by an estuarine clam under laboratory conditions.


Absorption of  137 Cs by Musca domestica and consequent environmental contamination.


Simulating energy and angle distributions above infinite plane cobalt-60 sources.


Radiation emission from a television projection system.


Radiological protection of workers exposed to airborne plutonium particulate.


Calculation of spectra of energy deposited by recoil heavy particles.


Energy loss of heavy charged particles.

Energy loss of heavy charged particles.


Average exposure to radiation workers in Pakistan.


An 1251 thyroid uptake system.

An 1251 thyroid uptake system.


Explanation of supralinearity in thermoluminescence of LiF in terms of the interacting track model.


On the fluorescence decay of silver-activated glass dosimeters.


Radiation exposure from a shoe-fitting fluoroscope.


Dosimetry using optical density changes in LiF.


Computer evaluation of monoenergetic neutron irradiations in radiobiology.


The measurement of the L.E.T. distribution within a reactor environment.


A thermoluminescent personnel neutron dosimeter.


Agreggation and precipitation in cryoglobulin.


[Prader-Willi syndrome].

[Prader-Willi syndrome].


A mixed photoproduct of thymine and cysteine: 5-S-cysteine, 6-hydrothymine.


Proteins in tobacco mosaic virus-infected tobacco plants.


Cytoplasmic inheritance of oligomycin and rutamycin resistance in yeast.


Acyl dihydroxyacetone phosphate: precursor of alkyl ethers.


The effects of 2,3-diphosphoglycerate on the kinetics of deoxygenation of human hemoglobin.


An allosteric and a non-allosteric guanine deaminase isozyme in rat liver supernatant.


Processing of ribosomal RNA precursor in isolated insect nuclei.


Studies on the photopigment system in Phycomyces.


An optical absorption change that could be due to reduction of the primary photochemical electron acceptor in photosynthetic reaction centers.


Effect of photosynthesis, photosynthetic inhibitors and oxygen on the activity of ribulose 5-phosphate kinase.


Identification of 2-hydroxyputrescine in a pseudomonad lacking spermidine.


Phosphonolipids in Tetrahymena cilia.

Phosphonolipids in Tetrahymena cilia.


4-pyridoxic acid 5'-phosphate: a metabolite of pyridoxol in the rat.


Inhibition of transfer factor Ts by aurintricarboxylic acid.


A possible role for chemically-produced excited states in biology.


Relation between the deposition of long lived fission products and the total dietary ingestion.


Seasonal variation and distribution of 65Zn, 54Mn and 51Cr in tissues of the crab Cancer magister Dana.


Cylindrical plastic scintillators for monitoring beta-gamma-activity in air and water.


Radiation dosimetry by optically-stimulated luminescence of BeO.


Effect of absorbers on alpha spectral measurements.


Photon energy emission from spallation products produced by 3-13 GeV electrons.


On neutron dosimetry by semiconductor detectors and hydrogenous radiator assembly.


Effects of grain size and initial trap density on superlinearity of LiF-TLD.


Free-nucleon target model applied to penetration and dose calculations for 200 and 400 McV protons and neutrons.


Concerning the relationship of lead-210 and inhalation exposure to radon-222.


Interaction of beta particles with thin films.


Some reflections on the nature of "civilization diseases".


[Mortality from congenital malformations in Venezuela from 1960 to 1967 and its comparison with the 1950-59 decade].


The most important indices for the assessment of the health state and medical care of the population.


Considerations on "excess mortality" in influenza.


Improved organization of the hospital work.


Prognosis of drug consumption.

Prognosis of drug consumption.


Influence of vitamin B 12 and glucose cycloacetoacetate hydrolysate to oxidative phosphorylation in liver mitochondria of rats fed an atherogenic diet.


Effect of Acacia catechu on niacin, ascorbic acid and riboflavin status in rats.


Antithiamine effect of ethyldeoxythiamine.


Studies on myoinositol. VII. Removal of deposited fats from dietary fatty liver.


Effect of myoinositol on skin cholesterol levels in rats maintained on a low protein, myoinositol deficient diet.


Isolation and properties of mutants of Lactobacillus fermenti resistant to Amprolium.


Immunological changes in Crohn's disease: attempt at devising a new diagnostic test.


In-vivo estimations of the nonlinear pressure-volume relationship of the aorta and instantaneous left ventricular volume.


Effects of anisotropy and nonhomogeneity on left ventricular stresses in the intact heart.


Mathematical biology of automobile driving. V.


A correction for the effect of the dead space in pulmonary gas washout tests.


Respiration of tissue as a medium of heterogeneous permeability.


Some remarks on the Kedem-Katchalsky equations for non-electrolytes.


Contributions to the theory of organismic sets: why are there only two sexes?


The motion of the left ventricle. 3.

The motion of the left ventricle. 3.


The application of the minimal energy hypothesis to a Casson fluid.


Analytical solutions for the specific activities of a traced substance within the component parts of a simulated kidney-ureter system.


Chorioretinal thermal behavior.

Chorioretinal thermal behavior.


The preload of individual myocardial fibers.


The identification of transport parameters from truncated physiological tracer curves.


Calculation of temperature increase in the eye produced by intense light.


Gompertz curves, allometry and embryogenesis.


Monte Carlo simulation of PLM-curves and collection functions.


On the average cellular volume in synchronized cell populations.


A note on the dispersionless growth law for single cells.


Dynamic analysis, with feedback characterization, of hybrid human musculo-skeletal frameworks by the linegraph-flowgraph procedure.


The approximation method, relational biology and organismic sets.


On the mass distribution model for microbial cell populations.


An application of statistical models in mental health research.


A concentric layer model for estimating the energy expenditure of the left ventricle.


Physiological significance of the geometrical shape of the left ventricle: course and curvature of the individual myocardial fibers.


Naturally occurring concentrations of alpha-emitting isotopes in a New England population.


Radiation quantities and their significance in health physics--1 and 2.


Thermoluminescent dosimetry of aluminum oxide.


Effect of iodine concentration on the efficiency of activated charcoal adsorbers.


Health workers in the United Kingdom Atomic Energy Authority.


A simple means for reducing unnecessary patient dose in radiology  departments.


A practical hand-shoe monitor.

A practical hand-shoe monitor.


Short-term effects of acute sublethal gamma radiation on populations of the old-field mouse, Peromyscus polionotus.


Comment on "effective transmission of the human thorax for photons from 239 Pu, 241 Am and other low-energy emitters".


Commentary on: health of workers in the United Kingdom Atomic Energy Authority by K. P. Duncan and R. W. Howell.


Performance of glass dosimeters and film dosimeter in personnel monitoring.


Skin absorption of plutonium in DMSO solution.


Dose assessment from the UA-RR-1 reactor channel.


Stopping power and range of alpha particles.


Mixed disciplines: a brief survey of educational problems.


Growth inhibitory activity in the supernatants of nondividing WI-38 cells.


Chemotherapy of spontaneous leukemia in germfree AKR mice.


Development properties of fission fragments tracks in natural mica.


Nutrition and eye cancer in cattle.

Nutrition and eye cancer in cattle.


Urethan carcinogenesis in rats: importance of age and dose.


Strain differences in response of the mouse mammary gland to hormones in vitro.


Observer disagreement in the classification and histology of Hodgkin's disease.


Histoproliferative effect of Rauscher leukemia virus on lymphatic tissue. 3. Alterations in the thymic-dependent area induced by the passenger lactic dehydrogenase virus.


Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine.


Quantitative in vitro assay of cytotoxic cellular immunity.


Karyotype analysis of the B16 mouse melanoma with reassessment of the normal mouse idiogram.


Morphologic study of immediate and delayed hypersensitivity to an isogeneic mouse tumor.


Candida infections.

Candida infections.


On the phenomenon of reversion and dereversion in the mitotic cycle.


Dosage-depth relationship for a collimated  90 Sr- 90 Y beam.


Dose reduction factor produced by intraperitoneal administration of phytohemagglutinin in mice.


A new technique for reactor siting dose calculations.


The effect of ionizing radiation on the reproductive capacity of forest trees.


Application of cellulose nitrate films for alpha autoradiography of bone.


Linear absorption coefficients for gamma-rays in tissue.


MPC values for  102 Rh,  102m Rh and  107 Pd.


Light sensitivity of LiF thermoluminescent dosimeters.


In-vivo and bioassay results from two contrasting cases of plutonium-239 inhalation.


Relations between structure and function in rat skeletal muscle fibers. The fast-twitch extensor digitorum longus (EDL) and the slow-twitch soleus muscle of the rat consist of heterogeneous fiber populations. EDL muscle fibers differ in size, mitochondrial content, myoglobin concentration, and thickness of the Z line. The sarcoplasmic reticulum, on the other hand, is richly developed in all fibers, with only small variation. Myofibrils are clearly circumscribed at both the A and I band level. The soleus muscle is composed primarily of fibers with moderate mitochondrial content and myoglobin concentration. In most fibers the sarcoplasmic reticulum is poorly developed, with the exception of the portion of reticulum in phase with the Z line. As a consequence the myofibrillar fields are amply fused together. Contacts between sarcoplasmic reticulum and T system are discontinuous and may occur in the form of "dyads" instead of the typical triad structure. In a small proportion of soleus muscle fibers the organization and development of the sarcoplasmic reticulum is similar to that of EDL muscle fibers, with prominent fenestrated collars at the H band level. In these fibers mitochondria are larger and more abundant. The results are correlated with physiological studies on motor units in the same and in similar rat muscles. It is suggested that the variable structural pattern of rat muscle fibers is related to two distinct physiological parameters, speed of contraction and resistance to fatigue.


Separation of nuclei representing different phases of the growth cycle from unsynchronized mammalian cell cultures. Nuclei have been isolated from unsynchronized cultures of Chinese hamster fibroblasts after varying intervals of growth following the incorporation of thymidine (-3)H for 20 min. These nuclei were fractionated by unit gravity sedimentation in a stabilizing density gradient of sucrose, and fractions were analyzed for the concentration of nuclei, DNA, and radioactivity. A more rapidly sedimenting population of nuclei in the G(2) phase of the cell cycle was separated from a group of nuclei in the G(1) phase, and nuclei in progressive stages of DNA synthesis (S phase) were distributed between these two regions. The fractionation of intact cells by sedimentation according to their position in the cell cycle was found to be less satisfactory than the corresponding separation of nuclei. This probably results from the continuous accumulation of mass within individual cells throughout the entire cell cycle, whereas most of the mass of a nucleus is replicated during a relatively narrow interval of the total cell cycle.


Chromosomal basis of dosage compensation in Drosophila. 3. Early completion of replication by the polytene X-chromosome in male: further evidence and its implications. Thymidine-(3)H labeling patterns on the X (section 1 A to 12 E of Bridges' map) and 2 R (section 56 F to 60 F of Bridges' map) segments in the salivary gland chromosomes of Drosophila melanogaster have been analyzed in male and female separately. The observed patterns fit, with a few exceptions, in a continuous to discontinuous labeling sequence. In nuclei with similar labeling patterns on the 2R segment in both sexes, the number of labeled sites on the X in male is always less than in female X's. The labeling frequency of the different sites on the male X is considerably lower than those on the female X's, while the sites on the 2R segment have very similar frequency in the two sexes. The rate of thymidine-(3)H incorporation (as judged by visual grain counting) is relatively higher in male X than in female X's. It is concluded that the model sequence of replication in polytene chromosomes follows a continuous to discontinuous labeling sequence, and that the single X in male completes its replication earlier than either the autosomes in male or the X's in female. This asynchronous and faster rate of replication by the polytene X-chromosome in male substantiates the hypothesis of hyperactivity of the single X in male as the chromosomal basis of dosage compensation in Drosophila.


Transitional cardiac cells of the conductive system of the dog heart. Distinguishing morphological and electrophysiological features. Cardiac cells with distinctive electrophysiological and morphological features were found at the junctional region between Purkinje and ventricular cells of the dog heart. The electrophysiological exploration of these "transitional" cells revealed action potentials markedly different in configuration from those generated by Purkinje or by ventricular cells. The impaled cardiac cells which generated transitional action potentials were identified in serial sections and studied with the light and the electron microscopes. The transitional cells were found to be characterized cytologically by: (a) their subendocardial location, (b) their small diameter, (c) the absence of T system and sarcoplasmic reticulum, and (d) the lack of intercalated discs under the light microscope and the sparsity of specialized intercellular junctions under the electron microscope. Purkinje, transitional, and ventricular cells were found to be joined by gap junctions permeable to lanthanum. A quantitative difference in the extent and distribution of specialized intercellular junctions may be one of the factors responsible for the slow velocity of conduction characteristic of the Purkinje-ventricular junctional region.


The development of the dorsal and ventral mammalian pancreas in vivo and in vitro. The origin, morphogenesis, and biochemical differentiation of the dorsal and ventral pancreas of the rat embryo have been investigated in order to ascertain the similarities and dissimilarities between the two lobes. We have utilized a culture system in which the primitive gut gives rise to a number of differentiated organs, including the dorsal and ventral pancreas. The two pancreases do not undergo fusion in these cultures, thus allowing independent analyses of the two lobes for comparison with in vivo results. The dorsal pancreas first appeared at the 23-25 somite stage while the ventral pancreas appeared approximately 12 hr later at the 29-30 somite stage. Guts from embryos as young as 12 somites were capable of developing both pancreases in vitro. In spite of the 12 hr difference between the times of their appearance, the dorsal and ventral pancreases exhibited identical patterns of morphological and biochemical differentiation. The two lobes contained the same exocrine enzymes and hormones, at similar levels, differing only in their glucagon content, the dorsal pancreas possessing a fivefold higher glucagon specific activity. The implications of these results are discussed.


Observation of filaments in the adrenal of androgen-treated rats.


The distribution of albumin synthesis throughout the liver lobule.


Capillary basal lamina thickening. Its relationship to endothelial cell death and replacement.


Prostaglandin-B 1 , embryonic skin, and the dermo-epidermal junction.


Deoxyribonucleic acid synthesis and mitosis in differentiated cardiac muscle cells of chick embryos.


Production of both prolactin and growth hormone by clonal strains of rat pituitary tumor cells. Differential effects of hydrocortisone and tissue extracts. Several established clonal strains of rat pituitary cells which produce growth hormone in culture have been shown to secrete a second protein hormone, prolactin. Prolactin was measured immunologically in culture medium and within cells by complement fixation. Rates of prolactin production varied from 6.6 to 12 microg/mg cell protein per 24 hr in four different cell strains. In these cultures ratios of production of prolactin to growth hormone varied from 1.0 to 4.1. A fifth clonal strain produced growth hormone but no detectable prolactin. Intracellular prolactin was equivalent to the amount secreted into medium in a period of about 1-2 hr. Both cycloheximide and puromycin suppressed prolactin production by at least 94%. Hydrocortisone (3 x 10(-6)M), which stimulated the production of growth hormone 4- to 8-fold in most of the cell strains, reduced the rate of prolactin production to less than 25% of that in control cultures. Conversely, addition of simple acid extracts of several tissues, including hypothalamus, to the medium of all strains increased the rate of production of prolactin six to nine times and decreased growth hormone production by about 50%. We conclude that multifunctional rat pituitary cells in culture show unusual promise for further studies of the control of expression of organ-specific activities in mammalian cells.


Effects of fixation and substrate protection on the isoenzymes of aspartate aminotransferase studied in a quantitative cytochemical model system. The cytochemical technique of Lee and Torack for the demonstration of aspartate aminotransferase activity was tested on a model system consisting of either total liver homogenate or the mitochondrial or soluble cytoplasmic fraction, incorporated in polyacrylamide film. After incubation of portions of film in a medium of alpha-ketoglutarate, L-aspartate, and lead nitrate, the lead oxaloacetate formed was converted to lead sulfide. The absorbance determined at 520 nm in a film spectrophotometer and expressed in terms of unit weight of film provided a measure of the contained enzymatic activity, and was directly proportional to the concentration of chemically determined oxaloacetate in the film. Both mitochondrial and "soluble" isozymes of aspartate aminotransferase reacted with the cytochemical media to a quantitatively similar degree, but were considerably inactivated after 15 min of treatment with 1% glutaraldehyde or 3.7% formaldehyde in imidazole buffer, the rate of inactivation being greater for the soluble isozyme. Application of the principle of substrate protection delayed inactivation. Thus, for both isozymes the rate of inactivation decreased if ketoglutarate was added to the fixative. Similarly, it was shown that the optimal incubation medium for the demonstration of the soluble isozyme must contain 4 mM of alpha-ketoglutarate and 20 mM of L-aspartate. Under these conditions the turnover-number for the cytochemical system is 70% of the value obtained from biochemical estimations. Cytochemical K(m) values differed for each isozyme and were in accord with values determined by biochemical techniques, indicating that the model system can be used as a link between biochemical and cytochemical data in enzymatic studies.


Distribution of labeled chromatin. I. M 1  and M 2  anaphases of diploid and tetraploid cultured mammalian cells. The question of whether distribution of chromatids to daughter cells in mitosis is a random or nonrandom process was investigated by study of the distribution of labeled chromatin in anaphase pairs at M(1) and M(2) after a pulse of tritiated thymidine. Diploid and tetraploid rat and diploid human fibroblast-like cells in serial monlayer culture were synchronized by two different methods to "purify" M(1) and M(2) anaphases: metaphase shake, and FUdR block to DNA synthesis followed by exogenous thymidine. Exposed grains of NTB-2 emulsion were counted over M(1) and M(2) anaphase pairs. An analysis (by pair) of diploid M(2) anaphase grain counts showed two discrete populations of daughters with less and with more radioactivity. A similar analysis of diploid M(1) and tetrapolid M(2) anaphases showed a single grain-count distribution. These findings may support a nonrandom model of chromatid segregation for diploid mammalian cells but do not rule out random segregation until sound mathematical models are formulated for expected random grain distributions in M(2) anaphases of cells with differing numbers of chromosomes.


The choice of therapy in the treatment of cancer.


Sensitivity of Salmonella paratyphi B to colicines and phase variation.


Kinetic studies on sorbose fermentation.


A biological model for the assay of typhoid vaccines.


A sensitive procedure for the estimation of deoxyribonucleic acid by the diphenylamine reaction in the presence of cupric sulfate.


Experimental demonstration of ATP on the muscle cell surface.


Anomalous course of the testicular artery in the rat.


Surgical correction of drop foot in leprosy following Carayon's technique: survey of 50 cases.


Cerebellar granule cells in vitro. A light and electron microscope study. The behavior of granule cells in mature cerebellar cultures derived from newborn mice was studied by light and electron microscopy. Many granule cells remained in the explants as an external granular layer. These cells were differentiated, as evidenced by formation of bundles of parallel fibers and by development of synapses between granule cell axons and Purkinje cell branchlet spines, and between Golgi cell axons and granule cell dendrites. Although the over-all architecture of the cerebellar explants after 18-33 days in vitro was similar to that of the newborn mouse, the evident differentiation of the granule cells suggested that interneuronal relationships resemble those of the mature cerebellum in vivo.


Comparative studies on mitochondria isolated from neuron-enriched and glia-enriched fractions of rabbit and beef brain. Fractions enriched in neuronal and glial cells were obtained from dispersions of whole beef brain and rabbit cerebral cortex by large-scale density gradient centrifugation procedures. The fractions were characterized by appropriate microscopic observation. Mitochondria were then isolated from these fractions by differential centrifugation of their homogenates. The two different types of mitochondria were characterized with respect to certain enzyme activities, respiratory rate, rate of protein synthesis, and their buoyant density in sucrose gradients. The mitochondria from the neuron-enriched fraction were distinguished by a higher rate of incorporation of amino acids into protein, higher cytochrome oxidase activity, and a higher buoyant density in sucrose density gradients. Mitochondria from the glia-enriched fraction showed relatively high monoamine oxidase and Na(+)- and K(+)-stimulated ATPase activities. The rates of oxidation of various substrates and the acceptor control ratios did not differ appreciably between the two types of mitochondria. The difference in the buoyant density of mitochondria isolated from the neuron-enriched and glia-enriched cell fractions was utilized in attempts to separate neuronal and glial mitochondria from the mixed mitochondria obtained from whole brain homogenates in shallow sucrose gradients. The appearance of two peaks of cytochrome oxidase, monoamine oxidase, and protein concentration in such gradients shows the potential feasibility of such an approach.


Scale formation in chrysophycean algae. I. Cellulosic and noncellulosic wall components made by the Golgi apparatus. The cell wall of the marine chrysophycean alga Pleurochrysis scherfellii is composed of distinct wall fragments embedded in a gelatinous mass. The latter is a polysaccharide of pectic character which is rich in galactose and ribose. These wall fragments are identified as scales. They have been isolated and purified from the vegetative mother cell walls after zoospore formation. Their ultrastructure is described in an electron microscope study combining sectioning, freeze-etch, and negative staining techniques. The scales consist of a layer of concentrically arranged microfibrils (ribbons with cross-sections of 12 to 25 x 25 to 40 A) and underlying radial fibrils of similar dimensions. Such a network-plate is densely coated with particles which are assumed to be identical to the pectic component. The microfibrils are resistant to strong alkaline treatment and have been identified as cellulose by different methods, including sugar analysis after total hydrolysis, proton resonance spectroscopical examination (NMR spectroscopy) of the benzoylated product, and diverse histochemical tests. The formation and secretion of the scales can be followed along the maturing Golgi cisternae starting from a pronounced dilated "polymerization center" as a completely intracisternal process which ends in the exocytotic extrusion of the scales. The scales reveal the very same ultrastructure within the Golgi cisternae as they do in the cell wall. The present finding represents the first evidence on cellulose formation by the Golgi apparatus and is discussed in relation to a basic scheme for cellulose synthesis in plant cells in general.


The association of a class of saltatory movements with microtubules in cultured cells. Particulate structures in the cytoplasm of HeLa and other cultured cells in interphase undergo rapid individual linear displacements (long saltatory movements, LSM). By the use of time-lapse microscopy to locate saltating particles prior to fixation and histochemical examination of the cells, structures of several kinds have been shown to move in this manner. Elements that show LSM include lysosomes, pinosomes, ingested carbon particles, lipoidal granules, and unidentified particles that appear as bright objects in positive phase contrast. The pattern of movement of the particles suggests the presence of linear guiding elements radially disposed from the cytocenter (centriole region). The participation of microtubules in these movements is inferred from the observation that LSM cease after treatment with drugs which depolymerize microtubules, i.e., colchicine, Vinblastine, and podophyllin. The directions of the microtubules in the cytoplasm of HeLa cells found by electron microscopy are consistent with the aster-like configuration predicted from study of LSM. Further support for this arrangement of cytoplasmic microtubules is provided by light microscope observations of colchicine-sensitive radial arrays of acid phosphatase granules in the cytoplasm of some cell lines.


A study of sieve element starch using sequential enzymatic digestion and electron microscopy. The fine structure of plastids and their starch deposits in differentiating sieve elements was studied in bean (Phaseolus vulgaris L.). Ultrastructural cytochemistry employing two carbohydrases specific for different linkages was then used to compare the chemical nature of "sieve tube starch" (the starch deposited in sieve elements) with that of the ordinary starch of other cell types. Hypocotyl tissue from seedlings was fixed in glutaraldehyde, postfixed in osmium tetroxide, and embedded in Epon-Araldite. Treatment of thin sections on uncoated copper grids with alpha-amylase or diastase at pH 6.8 to cleave alpha-(1 --> 4) bonds resulted in digestion of ordinary starch grains but not sieve element grains, as determined by electron microscopy. Since alpha-(1 --> 6) branch points in amylopectin-type starches make the adjacent alpha-(1 --> 4) linkages somewhat resistant to hydrolysis by alpha-amylase, other sections mounted on bare copper or gold grids were treated with pullulanase (a bacterial alpha-[1 --> 6] glucosidase) prior to digestion with diastase. Pullulanase did not digest sieve element starch, but rendered the starch digestible subsequently by alpha-amylase. Diastase followed by pullulanase did not result in digestion. The results provide evidence that sieve element starch is composed of highly branched molecules with numerous alpha-(1 --> 6) linkages.


The synthesis and turnover of rat liver peroxisomes. 3. The size distribution of peroxisomes and the incorporation of new catalase. Rat liver peroxisomes have been separated according to size by zonal sedimentation. A method is described for calculating the size of the particles from their final position in the gradient. Peroxisomes seem biochemically homogeneous throughout their size distribution. 3 hr after injection of tritiated leucine, the specific radioactivity of catalase is the same in peroxisomes of different sizes, and it remains so for up to 1 wk after administration of the precursor. This observation rules out the possibility that peroxisomes have an extended period of independent growth. If individual particles maintain an independent existence, they must be formed very rapidly. The other possible explanation is that peroxisomes exchange material within the liver cell.


Intermicrotubule bridges in mitotic spindle apparatus.


Variations in the sialic acid concentration of glomerular basement membrane preparations obtained by ultrasonic treatment.


The ultrastructure of the nuclear envelope of amphibian oocytes: a reinvestigation. 3. Actinomycin-induced decrease in central granules within the pores.


Filaments in the division furrow of mouse mammary cells.


Tests for the evaluation of airborne hazards from radioactive surface contamination.


Persistence of plutonium in soil, plants and small mammals.


The concentration of uranium in air from contrasted natural environments.


Absorption and distribution of  137 Cs by Trifolium pratense.


Size determination of airborne plutonium particles by autoscintigraphy.


Radioactivity in the diet of population of the Kerala coast including monazite bearing high radiation areas.


Radiation control in diagnostic roentgenology.


The attenuation of 14 MeV neutrons in water.


On the application of the uncertainty principle to stopping power theorfies.


An alpha detector insensitive to high neutron and gamma backgrounds and temperature.


The neutron-shielding qualities of water-extended-polyesters.


The equivalent energy of 2 and 3 kVp x-rays.


Effect of quenching temperature and rate on thermoluminescence in high purity lithium fluoride.


Reply to comment on "effective transmission of the human thorax for photons from  239 Pu,  241 Am, and other low-energy emitters".


Plowshare: new challenge for the health physicist.


Radioactive pollution of rivers in Czechoslovakia.


Studies on major and trace element content in human tissues.


Radioactivity in the diet in high background areas of Brazil.


A sequential neutron and gamma ray monitor.


A new procedure for purifying water for radiation chemistry.


An automated system for rapid determination of half-value thickness.


Fast drying strippable protective cover for radioactive decontamination.


Usable count-rate range of a halogen quenched Geiger-Müller (G-M) counter.


Navy adopts Kodak Type 3 film for centralized photodosimetry program.


Modification of the Tsivoglou method for radon daughters in air.


Pocket radiation dose integrator and monitor.