Quantitative measurement of iron stores with diethylenetriamine penta-acetic acid. The use of the chelating agent diethylenetriamine penta-acetic acid (DTPA) for measuring body storage iron was investigated in patients with iron excess whose stores could be determined by venesection. Iron excretion after DTPA bore a close semi-logarithmic relationship to body iron stores when these were increased. The excretion of DTPA-bound (59)Fe was similarly related to the size of the stores, indicating that the increased iron excretion produced by DTPA in iron overload states reflects both increased tissue iron available for chelation and greater stability of the iron-chelate complex. Evidence was obtained that injected (59)Fe-DTPA could be used as a marker for chelated tissue iron enabling the DTPA-chelatable body iron pool to be calculated. There was a highly significant correlation between DTPA-chelatable iron and body storage iron. The regression intercept approximated to the origin, implying a specific relation between the DTPA effect and storage iron. The SE of the mean estimate for storage iron on DTPA-chelatable iron was 0.25 g (5.6%). Mean storage iron values of 392 mg for males and 243 mg for females were predicted from the findings in control subjects.


Measurement of iron stores in cirrhosis using diethylenetriamine penta-acetic acid. The chelating agent diethylenetriamine penta-acetic acid was used to measure iron stores in 83 patients with chronic liver disease. Iron chelation was normal in patients with chronic cholestasis. Chelation was increased above the control range in 14 out of 26 patients with alcoholic cirrhosis, in nine out of 28 patients with non-alcoholic cirrhosis, and in 11 out of 15 cirrhotics with a portacaval anastomosis. Iron stores in excess of 1.5 g were predicted from the results in 24 subjects; however, in only three were the values in the range found in propositi with untreated idiopathic haemochromatosis. Increased chelation did not correlate with hepatocellular impairment per se but was associated in 18 cases with surgical or large spontaneous portal systemic shunts. Exogenous factors for excess iron were present in three cases with alcoholic cirrhosis and portal systemic collaterals in one, but no special factor apart from alcoholism was apparent in the remainder. The correlation between chelatable iron and stainable liver iron content was not close and was better in haemochromatosis than in other forms of cirrhosis; in some cases considerable siderosis was present with normal or only slightly increased chelation values.


Ultrastructure of the liver in non-cirrhotic portal fibrosis with portal hypertension. The aetiology of the ultrastructural abnormalities of non-cirrhotic portal fibrosis is not known. In an attempt to elucidate the pathophysiology of this condition, the hepatic ultrastructure in nine cases of non-cirrhotic portal fibrosis with portal hypertension has been studied.


Surgery in amoebic colitis.

Surgery in amoebic colitis. The feasibility of surgery in amoebic colitis is presented by illustrative case histories in two patients. Subtotal colectomy and ileostomy were carried out for fulminating colitis in the one and exteriorization, excision, and subsequent re-anastomosis of a localized perforated area of bowel in the other. It is suggested that the place of surgery in amoebic colitis should be reappraised, particularly with the advent of modern medical and surgical methods now available. The indications for contemplating surgery in abdominal amoebiasis are outlined and a workable approach is presented.


A comparative radiographic and pathological study of intestinal vaso-architecture in Crohn's disease and in ulcerative colitis. Vascular changes were seen in specimens with lesions of Crohn's disease as well as in ulcerative colitis. In Crohn's disease, the vasculature in the bowel wall was rearranged secondary to thickening of the intestinal coats. An anatomical relationship was often found between the ulcers and the point where arteries break through the muscularis propria. The vasculature was markedly increased in areas with deep ulcers and transmural inflammation, but in areas with only small ulcers and mild inflammatory reaction vascular changes were barely discernible or absent. Occlusive vascular changes were uncommon and not visible in the radiographs. In active ulcerative colitis hypervascularity was more marked than in Crohn's disease, but was confined to the mucosa and adjacent parts of the submucosa. In ;burnt-out' atrophy vascularity was not increased and only minor changes in the submucosal arteries were observed. The observations did not suggest that the vascular alterations are of primary importance for the formation of lesions in either disease.


Further studies on the perfusion method for measuring intestinal absorption in man: the effects of a proximal occlusive balloon and a mixing segment. The reliability and accuracy of the two-lumen tube perfusion method for measuring intestinal absorption in man has been assessed by the use of a proximal occlusive balloon in nine normal volunteers. Luminal occlusion significantly reduced the variability of individual glucose and water absorption rates, and reduced the variability of triplicate marker concentrations within individual studies. Mean absorption rates of glucose, water, sodium, and chloride were not significantly affected by luminal occlusion. Absorption rates obtained with the triple-lumen tube method were rather more variable both within and between individuals, but a statistical comparison of the accuracy of the two methods could not be made. These results are discussed in relation to the contribution of endogenous gut secretion and proximal reflux of infused fluid to the variability of absorption rates obtained by the perfusion technique.


A genteel device for collecting faeces.

A genteel device for collecting faeces.


Gastric acid secretion in Chinese with particular reference to the dose of histamine required for maximal stimulation. Studies of basal and histamine-stimulated gastric acid secretion were performed in 42 controls, in 133 patients with duodenal ulceration, in 57 patients with gastric ulceration, in 13 patients with both duodenal and gastric ulceration, and in 20 patients with gastric carcinoma. All these subjects were Chinese. Statistical analysis of the results showed that all clinical groups differed from the controls in both basal and stimulated secretion. The mean basal acid output of Chinese controls and of patients with duodenal ulcer in most cases did not differ statistically when compared with western series. The basal secretion of Chinese patients with gastric ulceration, however, was statistically higher than in most of the western series. The histamine-stimulated response of Chinese controls and patients with duodenal ulcer was statistically much lower than in all western series with which they were compared. For Chinese patients with gastric ulcer, the stimulated responses were in some instances lower than and in others similar to results obtained in some western series. In contrast to most western reports, the basal and histamine-stimulated secretion in Chinese patients with gastric ulcer was significantly higher than in controls. In the Chinese controls and Chinese patients with peptic ulcers the response after histamine was generally lower than western reports. This was due to the inadequacy of the standard dose of histamine acid phosphate of 0.04 mg/kg body weight in Chinese subjects. A dose of 0.06 mg/kg body weight produced a significantly higher acid output. In the comparatively leaner Chinese subjects, therefore, a dose of histamine acid phosphate of 0.06 mg/kg is required for maximal stimulation of gastric acid secretion. This agrees well with the results of a similar study in Indian subjects.


Plasma insulin response to oral carbohydrate in patients with glucose and lactose malabsorption. Plasma insulin levels were determined following oral glucose in 12 patients with adult coeliac disease, after oral lactose in four patients with alactasia, and in age-matched control subjects. In coeliac patients the insulin response was greater than expected from the small rise in blood sugar, and no correlation was found between plasma insulin and sugar levels at any period during the test. The separation of the plasma insulin curve from the blood sugar curve after glucose is in keeping with the concept that a factor responsible for stimulating insulin secretion is released from the gut during or after absorption of glucose. In patients with selective lactose malabsorption (alactasia) administration of lactose by mouth failed to elicit any insulin response, indicating that the insulin-releasing effect of the bowel is not activated merely by the presence of intraluminal carbohydrate.


Reticuloendothelial phagocytic function in human liver diseases.


Premature development of intrinsic factor-mediated vitamin B12 absorption in the infant rat.


Bile salt concentrations in chronic liver disease.


The effect of restraint stress on purine metabolism: a method of studying DNA synthesis in gastrointestinal mucosa.


The peptide fraction of human gastric juice.


Stool chromatography for sugar in children with diarrhoea.


Gastric autoimmunity in pernicious anaemia.


Aspects of protein metabolism in intestinal nematode infections.


Experience with the Olympus fiberoptic oesophagoscope (model EF).


Studies on serum gastrin levels in pernicious anaemia.


Great expectations.

Great expectations.


The after-hours psychiatric emergency.

The after-hours psychiatric emergency.


An evaluation of an information booklet for patients.


A study of overweight schoolchildren.

A study of overweight schoolchildren.


Personal points of view--the work of a District Doctor in Norway--some experiences.


Epidemiology of alcoholism in the Highlands and Islands.


Anaphylactic antibodies in the mouse. Relationship to mast cell degranulation during in vivo anaphylactic reactions.


Absence of immunogenic impurities in clinical dextran tested by passive cutaneous anaphylaxis.


Lysosomal activity in testes of guinea pigs immunized with aspermatogenic antigen.


'Delayed' peaks of DNA synthesis in phytohemagglutinin-stimulated human leucocyte cultures.


Effect of Freund's complete adjuvant on lysosomal enzymes.


Rosette-formation between human lymphocytes and sheep red cells not involving immunoglobulin receptors.


Macromolecular physiology of plastids. VI. Changes in membrane structure associated with shifts in the absorption maxima of the chlorophyllous pigments.


The mitral and short axon cells of the olfactory bulb.


An ultrastructural study of pyrenoids from Chlorella pyrenoidosa.


Some physiological and morphological effects of polylysine on Amoeba proteus.


Subsidiary components of the flagella of Chlamydomonas reinhardii.


A study of coagulation mechanisms in domestic chickens.


Synovitis induced by intra-articular inoculation of inactivated Mycoplasma mycoides in calves.


The experimental production of pneumonia in calves by the endobronchial inoculation of T-mycoplasmas.


The biology of Hyostrongylus ruidus. 3. Effect of host age on a primary infection.


The histopathology of Oesophagostomum dentatum infections in pigs.


The effect of excess vitamin A on longbone growth in kittens.


Solution conformation of ferrichrome, a microbial iron transport cyclohexapeptide, as deduced by high resolution proton magnetic resonance.


Fibrillar proteins from squid axons. I. Neurofilament protein.


Fibrillar proteins from squid axons. II. Microtubule protein.


Amino acid substitution (histidine to tyrosine) in a glucose-6-phosphate dehydrogenase variant (G6PD Hektoen) associated with over-production.


Structures of turnip crinkle and tomato bushy stunt viruses. 3. The chemical subunits: molecular weights and number of molecules per particle.


Social and psychological factors in the treatment of chronic alcoholism.


Patterns of report on the hearing of parental voices by emotionally disturbed children.


Discussion tasks as a measure of influence structure and reversal of role structure in normal families. Implications for the study of pathological families.


A naturally occurring red-cell antigen-antibody system in Beagle dogs.


The bone marrow of the dog: a comparative study of biopsy material obtained from the iliac crest, rib and sternum.


Attenuated measles virus vaccine dosage study in Central Africa.


Haemoglobin anomalies in Khartoum.

Haemoglobin anomalies in Khartoum.


Analysis of task difficulty under varying conditions of induced stress.


Field independence and the free-recall of nonsense syllables.


Order effects in perception of two trapezoidal illusions.


Effects of physical exertion on mental performance of college males of different physical fitness level.


Integrative functions in parkinsonism.

Integrative functions in parkinsonism.


Dream recall and cognitive style.

Dream recall and cognitive style.


Personality correlates of complexity-simplicity.


Effects of knowledge of the ITI on time estimates.


Reinforcement in figure-ground perception.


Relationship of motor proficiency and reading retardation.


"The birth of a test": the sensory quotient.


Relationship between measures of psychological differentiation and intellectual ability.


Cerebral dominance, psycholinguistic skills and reading disability.


Personality-impression formation as a function of visual cues and set.


Selection of visual dimensions by aphasics and non-aphasics.


Reaction time, agility, equilibrium, and kinesio-perceptual matching as predictors of intelligence.


Volume feedback and generalization techniques in shaping speech of an electively mute boy: a case study.


Facilitation of pursuit rotor learning by induced stress.


Myotonometry: a method for estimating tenseness and anxiety by measuring muscle hardness.


Visual alertness in neonates: individual differences and their correlates.


Relation of extent of temporal removals to closure and visuomotor factors.


Person perception accuracy as a function of ethnic group and familiarity.


Behavior in a mixed motive game as a function of induced self-esteem.


Choice for shape vs textural matching by young children.


Effects of discriminability and choice-figure rotation on visual perception of form.


Effects of shock on performance in visual backward masking.


Error increase and decrease in minimal form of Mueller-Lyer illusion.


Vocal mediating responses in short-term memory of severely and profoundly deaf children.


Relative effects of figural noise and rotation on the visual perception of form.


Visual-motor tasks at 3 and 4 years of age.


Spatial creativity in second year architecture students.


Effect of an "overload" concentric training of the quadriceps on strength and limb circumference in females.


Effect of threat of shock on pupillary response in a problem-solving situation.


EEG measures of arousal during RFT performance in "noise".


Prediction of brain damage in a neurological population with cerebrovascular accidents.


Emotional involvement while anticipating an examination: a psychophysical study.


Sex-linked inheritance of spatial ability.


Comparative study of three stretching techniques.


A factor analytic study of the subjective components of activation.


Vigilance performance under hypoxia. II. Effect of work-rest schedule.


Children's spatial representation of directional movement and figure orientations along horizontal and vertical dimensions.


Conditioning the pupillary reflex with control for the orienting response.


Restriction of emotional release and creativity.


Construction of a personality inventory through Thurstone scaling of daydreams.


The specters of technicism.

The specters of technicism.


Marijuana use among adults.

Marijuana use among adults.


Parties and cultural values: a kibbutz example.


An evaluation of long-term seminars in psychiatry for family physicians.


A musical idiot savant: a psychodynamic study,and some speculations on the creative process.


"What Kind of Fool Am I?" A study of popular songs in the analysis of a male hysteric.


Anonymous suicidal telephone calls: a research critique.


Family physician referrals for psychiatric consultation and patient initiative in seeking care.


Social and cultural factors associated with asthmatic symptoms in children.


A concept of structurated and destructurated group roles: an initial empirical reduction.


Communication problems as a possible contribution to chronicity in mental patients.


Environmental modification and differential health practices.


The social observatory: time series data for health and behavioral research.


A surgical procedure suggested for certain cases of reduplicated ureter.


Hydronephrosis in health and disease.

Hydronephrosis in health and disease.


Embryology of the male external genitalia.


Genetics and the urologist.

Genetics and the urologist.


Genitourinary tract abnormalities in Turner's syndrome (gonadal dysgenesis).


Preoperative irradiation as an adjuvant in the surgical management of invasive bladder carcinoma.


Anorchism: definition of a clinical entity.


Nucleic acid synthesis in ladder tumors.


Radiation therapy in the treatment of carcinoma of the prostate.


Temporary urinary diversion by ileal conduit.


Technique of vaginoplasty and clitoridectomy in the adrenogenital syndrome.


Renal artery thrombosis due to closed trauma.


[Dynamics of morphological changes in the liver during chronichepatitis (biopsy data)].


Modified motility-indole-ornithine-H2S medium (MIOH) for the routine identification of rapid lactose-fermenting enterobacteriaceae.


Subarcuate conglomerates in the temporal tegmen.


The rhinencephalon.

The rhinencephalon.


Dendritic organization of the ventral spinal gray matter in the cat.


Intrinsic nerve supply of the ventricles of the heart.


The contribution of the stapedial artery to the cephalic arterial supply in muroid rodents.


Considerations on the ependyma of the encephalic ventricles of Tropidonotus natrix, Alligator mississipiensis and Testudo graeca.


Study of cell multiplication in the cartilaginous upper end of the tibia of the domestic fowl by tritiated thymidine autoradiography.


Employment of collagen for constructing a mechano-chemical machine.


Instantaneous relative growth rates of preweanling rats as related to division of the sexes.


Investigation on a method measuring low energy x-ray doses with energy-dependent film dosemeter (short communication).


Physical conditions and dosimetry problems of experimental irradiations in radiobiology (short communication).


ATP-dependent enzymic splitting of mesitene lactone and triacetic acid lactone.


The subunit structure of light-meromyosin.


Transformation of a serine protease of Aspergillus oryzae into a thiol-enzyme.


Selective reaction of tyrosyl side chains with iodine in glyceraldehyde-3-phosphate dehydrogenase. 3. Specificity of the reaction in urea. Determination of reacting histidine and tryptophan (short communication).


Bound water in physics and biology.

Bound water in physics and biology.


Computer simulation of the pattern transfer of large cerebellar neuronal fields.


Quantitative researches into the volume decrease of the muscle. I.


Quantitative researches into the volume decrease of the muscle. II.


The influence of allosteric effectors on the conversion of phosphorylase-b.


A new view of the control of the morphogenesis of the skull.


Pulmonary effects of lethal and sublethal oxygen exposure in lambs.


Influence of common bile duct ligation on hepatic blood flow.


Artificial abdomen in diaphragmatic hernia.


A technic for investigating early allograft failure in venous replacement.


Rigid circumferential compression of the arterial wall.


Balloon catheter endarterectomy: a new technic of disobliteration in chronic occlusive arterial disease.


Amino acid-induced inhibition and stimulation of Saccharomyces carlsbergensis. I. Variations in the response to pantothenic acid induced by casein hydrolysate. The response pattern of Saccharomyces carlsbergensis (ATCC 9080) to pantothenic acid in Atkin's medium was changed dramatically by adding small amounts of casein hydrolysate (0.032 to 0.32 mg/ml) to the assay medium. Under static, mildly anaerobic conditions, growth at low pantothenic acid levels was reduced by 54 to 69%, whereas at saturating or near saturating pantothenate concentrations marked stimulation of growth (up to 41%) was observed. Under aerobic conditions, inhibition but not stimulation of growth occurred. It is recommended that Atkin's medium for the assay of pantothenic acid with S. carlsbergensis (ATCC 9080) be modified to include 0.6% acid-hydrolyzed casein (Vitamin Free Casamino Acids, Difco) to prevent erroneous growth responses, which may result if significant amounts of amino acids are present in natural materials being assayed for this vitamin.


Production of acetoin and diacetyl by the genus Salmonella. Members (all 42 tested) of the genus Salmonella, although Voges-Proskauer-negative when grown on MR-VP Medium, produce abundant quantities of acetoin or diacetyl, or both, when cultured on a minimal medium containing 1% glucose. The designation that the genus Salmonella does not produce acetoin should be re-examined.


Microbial aromatization of steroids into equilin. This report describes the bioconversion of 19-hydroxy-androsta-4, 7-diene-3, 17-dione into equilin with Nocardia rubra. Through mutation and improvement of medium and of conditions, the bioconversion could be improved to yield 40% equilin for a substrate concentration of 1 g/liter. Aromatization of several other 19-hydroxy and 19-nor substrates of the androstene series is reported, and the influence of various substitutions of the substrate molecule on aromatization is discussed.


Effect of trace elements on citric acid fermentation by Aspergillus niger. Citric acid yields of 98.7% (sugar consumption basis) were reached in shaker flasks with mutant UV-ET-71-15 of Aspergillus niger in a resin-treated sucrose medium of the following composition (g/100 ml): sucrose, 14.0; NH(4)NO(3), 0.20; KH(2)PO(4), 0.10; MgSO(4).7H(2)O, 0.025; and (mg/liter): FeSO(4), 0.15 to 0.75; ZnSO(4), 0.10; and CuSO(4), 0.01. Yields of 75% were obtained in medium with resin-treated clarified syrup and 68% with ferrocyanide-treated blackstrap molasses. Optimal conditions included selection of appropriate pellets as inoculum at 3%, pH of 4.5, temperature at 30 C, agitation at 250 rev/min, and fermentation time of 8 days. The mutant tolerated high concentrations of trace elements.


Inhibition of nucleic acid and protein synthesis mouse spleen cells in vitro by azathioprine. The effect of azathioprine on macromolecular biosynthesis was studied in mouse spleen cells cultured in vitro. The rate of incorporation of (3)H-thymidine, (3)H-uridine, and (14)C-leucine into acid-insoluble material was used to measure deoxyribonucleic acid, ribonucleic acid, and protein synthesis. Results indicate that azathioprine inhibited nucleic acid and protein synthesis at levels which did not decrease cell viability.


Stabilities of suspensions of influenza virus dried by sublimation of ice in vacuo to different contents of residual moisture and sealed under different gases. Suspensions of influenza virus were dried by sublimation of ice in vacuo to contents of residual moisture of 2.8, 1.6, or 0.6%. After drying, the preparations were sealed under helium, argon, nitrogen, or a mixture of oxygen and nitrogen (30% O(2), 70% N(2)). Stabilities of the several preparations were determined by an accelerated storage test. Based on the times predicted for the dried preparations stored at preselected temperatures to lose 1 log of infectivity titer, the order of stabilities in relation to residual moisture, gas was as follows: 1.6%, He > 0.6%, He > 2.8%, He > 1.6%, Ar > 2.8%, N(2) > 2.8%, Ar > 1.6%, N(2) > 2.8%, O(2) > 0.6%, Ar > 0.6%, N(2) > 1.6%, O(2) > 0.6%, O(2). The stability of the preparation sealed under helium and dried to the content of residual moisture found best for this gas (1.6%) resulted in an increased stability of the order of years as compared to the other preparations tested.


Improved device for the administration of fungal spores to small animals via the respiratory route. An improved device has been designed and constructed for the administration of fungal spores or other air-suspended particles to mice via inhalation. Fabricated from Lucite [0.25 inch (0.63 cm)], the device was built in the shape of a 6-inch (15.2-cm) cube with two 1-inch (2.5-cm) holes drilled in each side. Mice are restrained in plastic conical centrifuge tubes which fit into the holes by friction. The device is safe, easily cleaned and sterilized, and can accommodate up to eight animals at a single exposure.


Pyrolysis-gas-liquid chromatography of fungi: differentiation of species and strains of several members of the Aspergillus flavus group. Four fungi of the Aspergillus flavus group were differentiated to the species level and strain level by pyrolysis-gas-liquid chromotography. Comparisons of pyrochromatograms revealed more similarities than dissimilarities among both species and strains in the pyrolytic elution patterns. Quantitative analysis was made by comparing the number of peaks in which two strains or reference species agreed or disagreed, the degree of superimposability between the pyrolytic elution patterns of strains and reference species, and the presence or absence of peaks for strain pairs within each species. The accuracy and precision of these techniques suggest that pyrolysis-gas-liquid chromatography may have wide application in the detection, enumeration, and identification of fungi by nonmycologically trained personnel.


Malignant hyperthermia during anesthesia and surgery.


Ultrasound in retinal detachment. A preliminary report.


The changing character of the infected scleral implant.


Familial facial dysplasia.

Familial facial dysplasia.


Treatment of Behçet's disease with chlorambucil.


The rate of visual loss in Behçet's disease.


Ocular saccades in lateral rectus palsy.


Superior oblique myokymia. Report and discussion on five cases of benign intermittent uniocular microtremor.


Histiocytosis X affecting the uveal tract.


Melanomalytic glaucoma. Report of a case.


Meningioma of the optic nerve. Diagnosis by orbitography.


Superior limbic keratoconjunctivitis. Clinical and pathological correlations.


Acute chorioretinal infarction in sickle cell trait. Report of a case.


Direct visualization of the superior oblique tendon.


Reoccurrence of four-row rodless mice.

Reoccurrence of four-row rodless mice.


Intraocular production of interferon.

Intraocular production of interferon.


Critical oxygen tension at the corneal surface.


Marfan's syndrome.

Marfan's syndrome.


A preliminary study of the effect of chloroquine on the rat retina.


Concurrence of hereditary congenital cataracts and hereditary retinoblastoma.


Facial angiomatosis with angioid streaks. Association of angioid streaks with a component of the Sturge-Weber syndrome.


Chronic proliferative glomerulonephritis treated with alternate day steroid therapy.


Computers in medicine.

Computers in medicine.


Hepatitis associated antigen.

Hepatitis associated antigen.


Pulmonary function in aspergillus-sensitive asthma patients.


Survey of one hundred patients treated with cephalexin monohydrate in general practice.


Rupture of the oesophagus associated with acute pancreatitis.


Hyperextension of the head in breech presentation.


Diverticulitis with peritonitis mimicking appendicitis.


Vaginal operations for prolapse-the optimum day for discharge.


A stimulant to DNA synthesis in guinea-pig ear epidermis.


Absorption and excretion of 35S dapsone in dermatitis herpetiformis.


Surface appearances of the eccrine sweat duct by scanning electron microscopy.


Ultrastructural morphology and histochemistry (acid phosphatase) of the cutaneous infiltration by polyvinylpyrrolidone.


Experimentally induced acute oral candidosis in the rat.


The effect of methotrexate, corticosteroids and azathioprine on fingernail growth in psoriasis.


Direction of epithelial growth.

Direction of epithelial growth.


Evaluation of a simple surgical treatment of axillary hyperhidrosis.


The treatment of cutaneous porphyria with chloroquine or D-penicillamine.


The treatment of Kyrle's disease.

The treatment of Kyrle's disease.


Actinic reticuloid.

Actinic reticuloid.


Chronic moniliasis.

Chronic moniliasis.


Eggs and iron absorption.

Eggs and iron absorption.


Factor V: an activator of factor Xa in the absence of prothrombin.


The half-life of factor XIII in vivo.

The half-life of factor XIII in vivo.


Quantitative haemagglutination. II. A method for assaying red cell antigens using the autoanalyzer.


Quantitative haemagglutination. 3. Stuies of separated populations of human red blood cells of different densities.


Proliferation of erythroblasts in beta-thalassaemia.


A comparative study of hypersplenism in reactive and congestive splenomegaly.


Saline agglutinating anti-K and anti-k in the apparent absence of IgM antibody.


Multiple fistulation of the horse's large intestine.


Somatic cell count and bacterial growth in milk.


Transformation of the marker of the competence factor from Streptococcus challis to Streptococcus wicky.


The presence of two aminopeptidases in the ram seminal fluid.


Regeneration of proliferative activity in the progeny of murine lymphoma cells L5178Y irradiated with X-rays.


Induced potassium uptake as a result of increased medium osmolarity in suspensions of Tetrahymena cells.


Accidental hypothermia.

Accidental hypothermia. Accidental hypothermia was studied in 11 patients, five of whom died. This condition occurs spontaneously, usually in a cold environment, and should be suspected in the comatose hypotensive patient. It is easily missed because regular clinical thermometers do not record extremely low body temperatures. It is distinguished from other forms of hypothermia by the very low body temperature and by the absence of recognized causes of hypothermia. Ten of the 11 patients were either alcoholic or diabetic. Intravascular thrombosis was the most common complication leading to death.


Detection of postoperative bronchopleural fistulas by radionuclide fog inhalation. Postoperative bronchopleural fistulas may be demonstrated quickly and safely by inhalation of nebulized (99m)Tc-albumin, or other similar radiopharmaceuticals. Posterior scintiphotographs of the distribution of the inhaled radioactive material are obtained with the gammaray scintillation camera while the patient is in the upright and lateral decubitus positions. The observation of radioactive material in the pleural cavity indicates an abnormal communication.The radiation-absorbed doses for lung and total body are well within acceptable limits when a (99m)Tc tag is used. About 15 minutes are required to complete this relatively safe diagnostic test.


Optic neuritis and compressive neuropathy associated with cat scratch disease.


Fractured cervical spine. (Case P53).

Fractured cervical spine. (Case P53).


Diazepam injectable as premedication for electrical cardioversion.


Accidental hypothermia.

Accidental hypothermia.


Newborn care in perspective.

Newborn care in perspective.


Voluntary sterilization.

Voluntary sterilization.


Drug-associated congenital abnormalities?


Taussig-Bing malformation, coarctation of the aorta, and reversed patent ductus arteriosus. Operative correction in an infant.


Systolic phases of the cardiac cycle in children.


Percutaneous heart catheterization in infants and children. I. Catheter placement and manipulation with guide wires.


Relationship of plasma digitoxin and digoxin to cardiac response following intravenous digitalization in man.


Permanent pacing of the left atrium for treatment of WPW tachycardia.


Retrograde activation of the His bundle during intermittent paired ventricular stimulation in the human heart.


A mechanism for "false" inhibition of demand pacemakers.


Abnormal left ventricular contraction in patients with mitral stenosis.


Right bundle-branch block associated with left superior or inferior intraventricular block. Clinical setting, prognosis, and relation to complete heart block.


Right bundle-branch block associated with left superior or inferior intraventricular block associated with acute myocardial infarction.


The diagnostic value of detecting coronary calcification.


Treatment of pulmonary embolism with urokinase. Results of clinical trial (phase 1).


The frontal plane vectorcardiogram in old inferior myocardial infarcton. II. Mid-to-late QRS changes.


Bacterial endocarditis following homograft replacement of the aortic valve.


Report of Inter-Society Commission for Heart Disease Resources. Prevention of Cardiovascular Disease. Primary prevention of the atherosclerotic diseases.


Dicrotic pulse after open heart operation.


Pediatric surgery in India. Some thoughts on its past, present and future.


Nutritional status of rural pre-school children. II. Clinical observations.


Growth pattern in the first year.

Growth pattern in the first year.


Medical aid to ships at sea (by radio transmission).


Some developmental characteristics in the newborn.


Evaluation of the CFTRI fish flour.

Evaluation of the CFTRI fish flour.


Serum iron and haematological values in school children.


Anemia in childhood.

Anemia in childhood.


Fish flour in Kwashiorkor.

Fish flour in Kwashiorkor.


Childhood psychosis.

Childhood psychosis.


Acute intermittent porphyria.

Acute intermittent porphyria.


Melotia. (A case report).

Melotia. (A case report).


Accident prevention in industry.

Accident prevention in industry.


The prevention of sports injuries.

The prevention of sports injuries.


National needs and pediatric education.

National needs and pediatric education.


Senility.

Senility.


Some thoughts on the future of the National Health Service.


The decade ahead.

The decade ahead.


Cerebro-retinal degeneration. Clinical and histopathological study.


Immunologic response of children in enteric fever by Widal test.


Urinary tract infections. I. Clinical and radiological observation.


The radiologist and the cardiac pacemaker.


Socio-economic factors in relation to birth weight.


Radiologic recognition of unusual sites of a transvenous catheter pacemaker.


Serum vitamin B 12 and or folic acid deficiency in childhood anaemias.


Radiologic diagnosis of pulmonary embolism including the application of full-chest tomography.


Measurement of intrathoracic circulation times with the gamma-ray scintillation camera.


The angiographic diagnosis of splenic and hepatic trauma.


Non-tropical sprue as a cause of megacolon. Report of a case.


Diatrizoate-induced total body opacification in the diagnosis of obstructive cholecystopathy.


Intestinal obstruction due to abnormal duodenal fixation in infants. Two case reports.


Combined duplication of the esophagus and stomach.


Esophageal rupture secondary to pyloric obstruction by a gastrostomy Foley catheter balloon.


Radionuclide scanning complementing high dose urography in children.


Roentgen diagnosis of acute epiglottitis in the adult.


Pulmonary interstitial emphysema in the newborn.


The Klippel-Trénaunay syndrome. A case report.


Octagon board for pediatric immobilization.


The variable manifestations of sclerosing fibrosis.


Demographic and psychosocial factors in acute illness reporting.


The effect of various drugs upon the course of anesthesia.


Effects of immunization programs on the incidence of communicable diseases in Louisiana.


Headache of nasal origin.

Headache of nasal origin.


5-fluorocytosine: a replacement for amphotericin B in the treatment of candida and cryptococcus neoformans infections?


Renal function in jaundice.

Renal function in jaundice.


An evaluation of a micro-technique for ASO titer determination.


Circulating triiodothyronine as identified by thin layer chromatography.


Family practice in North America.

Family practice in North America.


Effects of an anabolic steroid on the body and bone growth of rats fed with different levels of casein.


Giant-cell myocarditis. A report of three autopsy cases.


Intellectual development and its relationship to the nutritional status among school children.


Disturbance of atrio-ventricular conduction in a patient with thyrotoxic periodic paralysis.


Replication of R-factors in Proteus mirabilis: replication under relaxed control.


Crystallization of yeast phenylalanine transfer ribonucleic acid.


In vitro selection of bacteriophage Q-beta ribonucleic acid variants resistant to ethidium bromide.


Reaction of anthramycin with deoxyribonucleic acid.


Segmental flexibility in an antibody molecule.


Evidence for transport of preribosomal RNA from the nucleolus to the chromosomes in Chironomus tentans salivary gland cells.


Low molecular weight ribonucleic acid in rabbit reticulocyte ribosomes.


Differential sedimentation study on the dissociation and conformational change in hemoglobin.


Polysomal distribution of late bacteriophage T4 messenger RNA.


Morphogenesis of the tail fibre of bacteriophage T4: isolation and characterization of a component (the gene 34 product).


Poly 2-amino-6-N-methyladenylic acid: synthesis, characterization and interaction with polyuridylic acid.


The selection of teaching practices for vocational training.


General-practitioner obstetrics and maternity bed needs.


Leprosy.

Leprosy.


Essential hypertension and its treatment by the family physician. A study of sixty-one cases.


Growing old: a country practice survey.

Growing old: a country practice survey.


Patients and students in general practice.


Adolescence and drug abuse.

Adolescence and drug abuse.


Continuing education for general practice.


Car parking requirements in general practice.


Acupuncture.

Acupuncture.


Termination of pregnancy on psychiatric grounds.


Medicine--art of science?

Medicine--art of science?


Community paediatrics.

Community paediatrics.


The innervation of the human nipple.

The innervation of the human nipple.


Occupational health--in principle.

Occupational health--in principle.


Occupational health--in practice.

Occupational health--in practice.


Abortion: law, ethics and the value of life.


Constitution and functions of the medical research council.


Hooliganism and vandalism.

Hooliganism and vandalism.


Encephalomyelopathy following abdominal symptoms. Epidemiological and follow-up studies, histological changes of Auerbach's plexus, and urinary porphyrin.


Studies on blastogenesis of human lymphocytes by phytohemagglutinin, with special reference to changes of membrane potential during blastoid transformation.


Growth inhibition and radiosensitization of 5-fluorouracil in culture of HeLa cells.


Mechanism of interphasic death in radiation damage: photoreaction following ultraviolet microbeam irradiation at a nuclear and cytoplasmic part of living cells.


Air and water pollution in Yokkaichi: on the problems of environmental disruption and its control in Japan.


Radiobiological effects of solely nuclear and cytoplasmic irradiation with ultraviolet-microbeam in HeLa cells.


Normal rabbit vectorcardiogram.

Normal rabbit vectorcardiogram.


Vectorcardiogram in chronic pulmonary disease and experimental pulmonary embolism.


Gastric ulcer in fundic-gland area.

Gastric ulcer in fundic-gland area.


Studies on the chronic gastritis. II. Relationships of gastric diseases to smoking, drinking and blood type.


Pale cell acanthoma (Degos).

Pale cell acanthoma (Degos).


The inducible beta-galactosidase (beta-D-galactoside galactohydrolase EC 3.2.1.23) of Klebsiella aerogenes NCIB 9479.


Renal effects of antituberculous antibiotics.


[Application of fel tauri in cholagogs].


Acanthocytosis, normolipoproteinaemia and multiple tics.


Acanthocytosis with normolipoproteinaemia: biophysical aspects.


Acute intermittent porphyria in identical twins.


The hyperlipoproteinaemias.

The hyperlipoproteinaemias.


Hyperosmolar non-ketoacidotic coma as a complication of cerebral compression.


Haematological changes in a patient on long-term treatment with a trimethoprim-sulphonamide combination.


Intracranial A-V malformation associated with cranial bruit and cervical venous hum.


Quinidine-induced systemic lupus erythematosus.


The painful foot.

The painful foot.


Arthritis in systemic disease.

Arthritis in systemic disease.


Polymyalgia rheumatica.

Polymyalgia rheumatica.


Post-arthrotomy intra-articular steroids.


Canities of rapid onset due to diffuse alopecia.


An emergency plan for an offshore disaster.


Non-seasonal allergic rhinitis.

Non-seasonal allergic rhinitis.


Thamesmead and its mobile health centre.


Symptoms associated with acute otitis media in children.


Thoughts at random. A running commentary.


Modern views on physiology. 23. Central nervous system.


The three brothers. An ode to community medicine and its servants in the medical, natural and social sciences.


Psychological aspects of habitual abortion.


Orientation on group dynamics.

Orientation on group dynamics.


Interaction of electro-ocular potentials with the contingent negative variation.


Experimenter effects on the physiological experiment.


Circadian rhythms: a model for the interpretation of multimodal circadian spectra.


An inexpensive method for programming stimuli using magnetic tape.


Instrument for direct readout of log conductance (log 1-R) measures of the galvanic skin response.


A simple device for the polygraphic recording of judgments.


An instrument for predicting the occurrence of the P-R interval of the normal human electrocardiogram.


A technique for monitoring the heart rate of mice.


The GSR recovery limb in chronic schizophrenia.


Psychophysiological and cognitive development in children: the relationship of skin conductance and heart rate to word associations and task requirements.


The effects of awareness and successive inhibition on interoceptive and exteroceptive conditioning of the galvanic skin response.


A comparison of GSR and subjective adaptation to stressful stimuli.


The use of heart rate for the study of habituation in the neonate.


Stimulation in different phases of the cardiac cycle and reaction time.


Activation states as assessed by verbal report and four psychophysiological variables.


Differences in tracking skill and psychophysiological activation dynamics in children high or low in persistence in schoolwork.


Environmental survey of uranium mill tailings pile, Monument Valley, Ariz.


Children in flats.

Children in flats.


Designing for the elderly.

Designing for the elderly.


Results of a study of color television set assembly and repair workers X-ray safety.


The Abortion Act 1967. (a). The advantages and disadvantages.


The outlook for the mentally retarded. (b). Language and thinking in the subnormal.


The Abortion Act 1967. (b). The social aspects.


The Abortion Act 1967. (c). Implications for the family.


Changes in occupation and in health.

Changes in occupation and in health.


The outlook for the mentally retarded. (a). Parents' choice.


Alcoholism in Scotland including some Highland and Island occupational connotations.


The outlook for the mentally retarded. (c). Genetic counselling in relation to mental retardation.


Shift work--some medical and social factors.


Health of young people in industry.

Health of young people in industry.


Psychological upsets at a university Institute of Science and Technology.


Medical education from an international point of view.


Dietary modification as a means of the control of dental caries.


Flash photolysis of rhodopsin in the isolated frog retina.


Electroretinogram determinations of spectral sensitivity in a teleost fish adapted to different daylengths.


Identification of horizontal cells as S-potential generators in the cat retina by intracellular dye injection.


Acid phosphatase activity in the retinal pigment epithelium.


Pigment migration in the tapetum lucidum of the elasmobranch eye: evidence for a nervous mechanism.


Properties of the frog's retinal ganglion cells as revealed by substitution of chromatic stimuli.


Eye movements in the dark during the attempt to maintain a prior fixation position.


Spectral sensitivity of intracellular responses from visual cells in median ocellus of Limulus polyphemus.


Human cyclofusional response.

Human cyclofusional response.


An hypothesis on the extinction and color of rhodopsin.


Backward visual masking during direct brain stimulation in man.


Contour effects on a brightness paradox.


Color evoked brain responses in man.

Color evoked brain responses in man.


A comment on the role of choroidal papillae in the fruit bat retina.


Sensitization by annular surrounds: individual differences.


Cone pigment regeneration in the isolated frog retina.


A model of accommodation.

A model of accommodation.


Dichroism in the retina at -196 degrees C.


Visual pigment of Callorhinchus callorynchus, a southern hemisphere chimaeroid fish.


Threshold and action spectrum of the elasmobranch pupillary response.


Intracellularly recorded early receptor potential of the vertebrate photoreceptors.


Electrical responses from the eye of Helix to photic stimulation and simultaneous electrical stimulation of the optic nerve.


Stereochemical effects of amino acid substitution in abnormal human haemoglobin.


Vertebrate and insect haemoglobins.

Vertebrate and insect haemoglobins.


Mixed haemoglobin molecules.

Mixed haemoglobin molecules.


Myoglobin, with particular reference to the myoglobin of Aplysia.


Auto-reactivity to haemoglobin in the sera of cattle and sheep infected with haemolytic bacteria.


Conversion of pyruvate into citrate by mitochondria isolated from rat epididymal fat-cells.


Kinetics of 5-hydroxytryptamine exchange in rabbit blood platelets and its analysis by digital computer.


The intracellular distribution of acid-labile selenium in rat liver and the possible biological function of selenium and vitamin E.


The amino acid composition of the haemoglobins of the domestic fowl.


Methine-bridge specificity of the coupled oxidation of myoglobin and haemoglobin with ascorbate.


Observations on haemoglobin P (Congo type).


Ethanolamine plasmalogen metabolism in myelinating rat brain.


The use of zonal centrifugation in the preparation of subcellular fractions from brain tissue.


Biochemical studies of taurine in the developing rat brain.


Undernutrition and the development of certain enzymes in rat brain.


The progression of long-chain fatty acids from herbivore to carnivore and the evolution of the nervous system.


Lipolysis and the regulation of fatty acid metabolism in the liver.


Direct stimulation by insulin and fructose of very-low-density lipoprotein secretion by the perfused liver.


The site of fatty acid biosynthesis in the avocado pear.


Adipose-tissue lipoprotein lipase activity in rats adapted to controlled feeding schedules.


Interaction of insulin with phospholipid in a membrane model.


Post-mortem changes in liver microsomal protein-synthesizing activity.


Omega-oxidation of S-pentyl-L-cysteine.

Omega-oxidation of S-pentyl-L-cysteine.


Hydroxylation of 1-bromopentane involving cytochrome P-450.


The metabolism of 2-aminobiphenyl by rats in vivo.


Mercapturic acid formation from Allyl compounds in the rat.


The induction of hepatic microsomal enzymes by safrole.


The effects of development on the activity of drug-metabolizing enzymes in the liver of the rat.


Cytochrome c and the oxidation of C1 compounds in Pseudomonas AM1.


The alpha beta-elimination of L-serylglycine O-sulphate and related dipeptides.


The state of pigment-epithelium lysosomes in the retina of normal rats and those with retinitis pigmentosa.


Some studies on the biosynthesis of tocochromanols.


Low-molecular-weight nuclear ribonucleic acid synthesis after partial hepatectomy.


The isolation and properties of large amounts of messenger ribonucleic acid for mouse globin.


Studies on thio-bases in rat liver transfer ribonucleic acid.


Size and configuration of Tetrahymena mitochondrial deoxyribonucleic acid.


The mechanism and energetics of histone associations with deoxyribonucleic acid.


Subcellular distribution of rat liver L-alanine-glyoxylate aminotransferase.


A prostaglandin isomerase in cat plasma.


The role of haemocytes in the biosynthesis of protocatechuate in the cockroach colleterial system.


A possible new sclerotization agent in the cockroach cuticle.


Synthesis of unstable hemoglobins.

Synthesis of unstable hemoglobins.


Thermal denaturation of human haemoglobins.


Two new pathological haemoglobins: Olmsted beta 141 (H19) Leu leads to Arg and Malmö beta 97 (FG4) His leads to Gln.


Haemoglobin synthesis in thalassaemia.

Haemoglobin synthesis in thalassaemia.


Myoglobin variants.

Myoglobin variants.


The mechanism of action of rat liver glutamyl-transfer-ribonucleic acid synthetase.


Comprehensible models for myoglobin and haemoglobin.


A generalized system for automation of enzyme assays. A flow system was developed, using a Technicon AutoAnalyzer, that is readily adaptable to a range of enzyme assays. The system includes lines for pumping substrate, cofactor, buffer and enzyme and for generating linear gradients. By using a variable-speed proportioning pump the incubation time may be continuously varied, and the system also allows for continuous variation in the pH, substrate or cofactor concentration, incubation temperature and enzyme concentration. A FORTRAN V program was written that uses instrument calibrations to calculate the flow rates in the individual lines, the incubation time and the characteristics of the gradient used. The computer then prints out instructions for preparation of reagents to give a required reaction mixture, weighing sheets for stock solutions and the results of the assay in international units in suitable tables and graphs. The flow system and computer program are designed to facilitate the automation of manual assays. A detailed example is given of the use of the system [the assay of three dehydrogenases in yeast: l(+)-lactate dehydrogenase, d(-)-lactate dehydrogenase and succinate dehydrogenase], and the general applications of the method are discussed. The program has been deposited as Supplementary Publication no. SUP 50002 at the National Library for Science and Technology, Boston Spa, Yorks. LS23 7BQ, U.K., from whom copies may be obtained on the terms indicated in Biochem. J. (1970), 116, 7.


Co-metabolism of methyl- and chloro-substituted catechols by an Achromobacter sp. possessing a new meta-cleaving oxygenase. Co-metabolism of 3-methylcatechol, 4-chlorocatechol and 3,5-dichlorocatechol by an Achromobacter sp. was shown to result in the accumulation of 2-hydroxy-3-methylmuconic semialdehyde, 4-chloro-2-hydroxymuconic semialdehyde and 3,5-dichloro-2-hydroxymuconic semialdehyde respectively. Formation of these products indicated that cleavage of the aromatic nucleus of the substituted catechols was accomplished by a new meta-cleaving enzyme, catechol 1,6-oxygenase. This enzyme was equally active on both chloro- and methyl-substituted catechols.


Non-enzymic nature of the pyridine haemochrome-cleaving activity of mammalian tissue extracts ('haem alpha-methenyl oxygenase'). 1. The pyridine haemochrome-cleaving activity of extracts from mammalian liver and other tissues is shown conclusively to be entirely non-enzymic in nature and attributable to coupled oxidation with ascorbate. 2. Reduced glutathione probably contributes to the activity indirectly by continuously regenerating the ascorbate to the reduced form. 3. The cleavage shows no specificity for the alpha-methine bridge of pyridine haemochrome. 4. Results are presented suggesting some probable reasons for the erroneous characterization of the activity as an alpha-methine-specific haem-cleaving enzyme (;haem alpha-methenyl oxygenase') by Nakajima and co-workers (e.g. Nakajima, Takemura, Nakajima & Yamaoka, 1963; Nakajima & Gray, 1967).


Disappearance of isocitrate lyase enzyme from cells of Chlorella pyrenoidosa. 1. When acetate-adapted cells of Chlorella are suspended in nitrogen-free medium and supplied with glucose, isocitrate lyase activity disappears from the cells at a rate of about 9%/h. This loss of activity is shown to be accompanied by loss of isocitrate lyase protein. 2. When isocitrate lyase activity is assayed in intact cells after freezing and thawing, the rate of loss of activity after addition of glucose approaches 20%/h. 3. It is shown, by using (35)S, that the rate of turnover of isocitrate lyase protein is somewhat lower than that of other major soluble proteins; general protein turnover during nitrogen starvation, and after glucose addition, is too slow to account for the rate of loss of isocitrate lyase protein. 4. Disappearance of isocitrate lyase activity must result from a mechanism that allows degradation of this specific protein under conditions of limiting nitrogen supply.


Effects of adrenalectomy and bile-duct ligation on the urinary excretion of metabolites of 2-acetamidofluorene by male weanling rats.


Effect of development on chicken liver acetyl-coenzyme A carboxylase.


Ulcerative colitis.

Ulcerative colitis.


Uricaemic pleurisy.

Uricaemic pleurisy.


Renal amyloidosis and the nephrotic syndrome in a child.


Haemolysis due to folic acid deficiency.


Neuroti excoriations--a quantitative approach to the effect of treatment.


Mechanism of the hypotensive action of methyldopa in normal and immunosympathectomized rats. 1. The antihypertensive action of methyldopa was investigated in the light of the prevailing false sympathetic neurotransmitter hypothesis of Day & Rand (1963). Immunosympathectomized and normal animals were used for the investigation.2. Methyldopa in a single injection significantly decreased the blood pressure in control hypertensive, immunosympathectomized normotensive, and normal rats. Guanethidine did not decrease the blood pressure of immunosympathectomized rats; it decreased the blood pressure of control and control hypertensive rats.3. The hypotensive effect of methyldopa was not antagonized by adrenoceptor and ganglion blocking agents or by the inhibition of dopamine beta-oxidase.4. High doses of methyldopa produced less hypotension than relatively low doses. This might be due to an antagonism of the hypotensive effect by methylnoradrenaline, which is formed from methyldopa.5. The antihypertensive action of methyldopa could not be correlated with any change in aortic sodium or potassium.6. It is concluded that methyldopa does not exert its hypotensive effect by producing a weakly active false sympathetic neurotransmitter.


An assessment of the role of the sympathetic nervous system in experimental hypertension using normal and immunosympathectomized rats. 1. The role of the sympathetic nervous system in experimental hypertension and associated changes in aortic sodium and potassium was studied using normal and immunosympathectomized Sprague-Dawley rats.2. A single injection of antiserum to nerve-growth factor to rats at birth produced less intensive destruction of the peripheral sympathetic system than did two injections (one daily for 2 days). The former are referred to as "partial" immunosympathectomized and the latter as "total" immunosympathectomized rats.3. Maintenance of rats on 1% sodium chloride after unilateral nephrectomy and implantation of 40 mg desoxycorticosterone acetate (DOCA) pellets resulted in sustained DOCA-NaCl hypertension in both normal and "partial" immunosympathectomized rats but not in "total" immunosympathectomized rats. Hypertension was associated with an increase in aortic sodium.4. Constriction of one renal artery with contralateral nephrectomy caused sustained hypertension and an increase in aortic sodium in normal and "partial" immunosympathectomized rats. Renal hypertension in "total" immunosympathectomized rats was not sustained.5. It is concluded that a certain minimum control of the cardiovascular system by the sympathetic system is essential for the production of experimental hypertension and associated electrolyte changes.


Iontophoretic release of acetylcholine, noradrenaline, 5-hydroxytryptamine and D-lysergic acid diethylamide from micropipettes. 1. The in vitro iontophoretic release of tritium-labelled acetylcholine and 5-hydroxytryptamine from large and small micropipettes and noradrenaline and D-lysergic acid diethylamide from small micropipettes was determined by liquid scintillation counting.2. The release was directly proportional to the electrical charge passed in the range normally used in the iontophoretic study of these compounds. The transport numbers obtained for the large micropipettes were approximately double those with the small micropipettes. A very low transport number was found for D-lysergic acid diethylamide.3. The spontaneous leakage was small and did not vary appreciably with time.4. The iontophoretic release of acetylcholine in vitro agreed with the in vitro measurements.5. The brain-stem tissue concentration of D-lysergic acid diethylamide after intravenous injection into intact and decerebrate cats was determined.


The behaviour of horses recovering from anaesthesia.


Enhancement by potent diuretics of renal tubular necrosis induced by cephaloridine. 1. Administration of frusemide or ethacrynic acid to cephaloridine-treated mice increased both the incidence and extent of proximal renal tubular necrosis compared with that obtained in cephaloridine-treated control mice.2. Administration of frusemide to cephaloridine-treated rats produced significant changes in urine output, electrolyte excretion and proteinuria, and plasma urea nitrogen and creatinine values were significantly increased compared with controls or rats that received frusemide or cephaloridine alone.3. Histological examination of the kidneys showed a higher incidence and greater extent of tubular necrosis in rats that received both frusemide and cephaloridine.4. It is suggested that this adverse drug interaction may have contributed to the deterioration in renal function observed in some patients treated with diuretics and cephaloridine concurrently.


A cntral site for the hypothermic effects of (+)-amphetamine sulphate and p-hydroxyamphetamine hydrobromide in mice. 1. In unanaesthetized mice, weighing 20-30 g, the effect of (+)-amphetamine sulphate and p-hydroxyamphetamine hydrobromide on rectal temperature was examined. The drugs were injected intraperitoneally or into the cerebral ventricles.2. Amphetamine produced hypothermia when injected intraperitoneally in doses of 1-5 mg/kg and intraventricularly in doses of 0.5 to 25 mug. Injections of larger doses-10 mg/kg intraperitoneally and 400 mug intraventricularly-resulted in hyperthermia followed by hypothermia.3. Hydroxyamphetamine produced hypothermia only when given by the intra-ventricular route; the effect was obtained with 0.5 to 25 mug. An intraventricular injection of 200 mug resulted in hyperthermia followed by hypothermia. When injected intraperitoneally the sole effect on temperature was hyperthermia, and this response was obtained with 5 and 10 mg/kg.4. Hydroxyamphetamine injected intraperitoneally or intraventricularly in doses which produced hyperthermia reduced the noradrenaline but not the dopamine content of the brain. When injected intraventricularly in smaller doses which produced hypothermia no reduction in the noradrenaline content of the brain was obtained.5. The hypothermia is attributed to an action on the anterior hypothalamus, and the possibility is discussed that it is brought about indirectly by the release of noradrenaline. The hyperthermia on the other hand is probably a peripheral effect.


Effects of hemicholinium and bretylium on the release of autonomic transmitters in the isolated sino-atrial node. 1. In the isolated, spontaneously beating, sino-atrial node of the rabbit selective electrical excitation of intranodal autonomic nerve fibres results in a biphasic chronotropic response. This chronotropic response (negative followed by positive chronotropism) is due to the release of the autonomic transmitters (acetylcholine and noradrenaline, respectively) from intranodal nerve fibres.2. In the presence of 2 x 10(-4) g/ml hemicholinium, the negative chronotropic (cholinergic) response is abolished while the positive chronotropic (adrenergic) response is unaltered.3. In the presence of 5 x 10(-6) g/ml bretylium, the positive chronotropic response is abolished while the negative chronotropic response is little affected.4. After blockade of the negative chronotropic response by hemicholinium, bretylium abolishes the remaining positive chronotropic response. The effect of bretylium is not altered in the presence of hemicholinium.5. Considering currently accepted mechanisms of action for hemicholinium and bretylium, the results of these experiments do not lend support to the cholinergic link hypothesis of adrenergic neuro-effector transmission.


The role of monoamine oxidase in the response of the isolated central artery of the rabbit ear to tyramine. 1. Monoamine oxidase activity was demonstrated histochemically throughout the media of the rabbit ear artery but not in the adventitia at its border with the media where the sympathetic nerve terminals are concentrated. Neither intensity nor distribution of enzyme activity was perceptibly altered up to 60 days after sympathetic denervation.2. Iproniazid and nialamide increased the sensitivity of the artery to intraluminal tyramine much more than that to extraluminal tyramine, so that the difference between the potencies for the two routes of administration became less marked.3. The results indicate that inactivation by monoamine oxidase in the media is a factor contributing to the relatively low potency of intraluminal tyramine on the artery.


Histamine and granulocytes in the umbilical cord blood of infants at birth. 1. Histamine levels in whole blood and plasma from the umbilical arteries and veins, together with circulating basophil and eosinophil counts, were determined in two groups of healthy infants, "term" and "pre-term".2. No significant arteriovenous differences were found except in the basophil counts of the "pre-term" group. This result was consistent with the finding of significant arteriovenous correlations for all these sets of estimations except the basophil counts in the "pre-term" group.3. No significant differences were found between the mean values in either group except for the difference between the mean basophil counts for venous blood.4. Plasma histamine levels (arterial and venous) were usually less than the lowest limit of the method (1.8 ng/ml). Very small amounts of histamine were detected, however, in one venous and one arterial specimen in the "pre-term" group, but these did not produce a significant difference between the levels for the two groups of infants.


The effect of benzodiazepines and atropine on exploratory behaviour and motor activity of mice. 1. Male albino mice were watched in red light on a tunnel board to test exploration and their motor activity was assessed in an open cage, 30 min after intraperitoneal injection of drugs.2. Atropine and methylatropine 5 or 10 mg/kg did not alter the motor activity of the mice, while chlordiazepoxide 25 or 50 mg/kg and diazepam 10 or 20 mg/kg increased the activity, especially at the lower of the two doses used.3. All the compounds used except methylatropine adversely affected the exploratory behaviour.4. When atropine 10 mg/kg was given with the benzodiazepines, the activity of the mice was reduced and exploratory behaviour was further impaired. Methylatropine did not have this effect.


Investigations of acquired immunity to Trichostrongylus axei infections in seven-month-old lambs.


Synaptic potentials recorded by the sucrose-gap method from the rabbit superior cervical ganglion. 1. Compound ganglionic potentials evoked by stimulation of the preganglionic nerves to the superior cervical ganglion of the rabbit were recorded by the sucrose-gap method.2. When the distal part of the ganglion was bathed in flowing isotonic sucrose solution or sodium-deficient solutions, ganglionic action potentials were no longer evoked, only large synaptic potentials.3. The compound synaptic potential, which remained unaltered for more than 1 h, originated in a population of cells at the interface between the Krebs and sucrose solutions. Hexamethonium reduced the size but did not alter the time course of the synaptic potential.4. It is suggested that a higher concentration of sodium ions is required for the generation of ganglionic action potentials than for either conduction in the postganglionic axons or production of synaptic potentials.5. When lithium replaced sodium in the solution bathing the distal part of the ganglion, the synaptic potential was greatly reduced in amplitude. Impulse propagation in the postganglionic axons was only slightly impaired when lithium replaced sodium in the solution bathing the axons.6. A quantitative assessment of the potency of the ganglion-blocking drugs nicotine, pentolinium, hexamethonium and pempidine was made by measuring the depression of the synaptic potentials produced by bathing the distal part of the ganglion in flowing isotonic sucrose solution. The concentrations which produced a 50% depression were 8.1 muM nicotine, 26.5 muM pentolinium, 111 muM hexamethonium and 22.2 muM pempidine.


Simultaneous determination of urinary uronic acids and saccharic acids by gas chromatography.


Spectroscopic studies on molecular interactions. VI. Mechanism of metachromasy of 2-(4'-hydroxyphenylazo)benzoic acid by serum albumin.


Antitumor activity of Leguminosae plants constituents. I. Antitumor activity of constituents of Sophora subprostrata.


Pharmacokinetic studies of biliary excretion. I. Comparison of the excretion behavior in azo dyes and indigo carmine.


Antagonism of 5-hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25. 1. 5-Hydroxytryptamine (5-HT), acetylcholine (ACh), noradrenaline (NA), glutamate, D,L-homocysteic acid (DLH), glycine and gamma-aminobutyric acid (GABA) were applied to single neurones in the brain stem of decerebrate cats by microiontophoresis. The abilities of D-lysergic acid diethylamide tartrate (LSD 25), methysergide maleate (UML 491) and 2-bromo-lysergic acid diethylamide (BOL 148) to antagonize the actions of these compounds were studied.2. LSD 25 antagonized 5-HT excitation of single neurones when applied iontophoretically or administered intravenously. LSD 25 also antagonized glutamate excitation of neurones which could be excited by 5-HT. Inhibitory effects of 5-HT, the action of glutamate on neurones which could be inhibited by 5-HT and the actions of all the other compounds tested were unaffected by LSD 25.3. Iontophoretically applied UML 491 was also a specific antagonist to 5-HT and glutamate excitation but was less potent than LSD 25, and BOL 148 rarely exhibited antagonism.4. It is suggested that antagonism to 5-HT and glutamate excitation of brain stem neurones may be the basis of the psychotomimetic action of LSD 25. It is also suggested that there may be similarities in the mechanisms by which 5-HT and glutamate produce excitation where they act on the same neurone.


Effect of 5-n-butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine on the sulfonamides transfer in the rat.


Proteolytic enzymes. V. Further application of p-nitrophenyl p-amidinobenzoate as a titrant of trypsin.


Metabolism of drugs. LXXII. Synthesis of nalorphine-3- and -6-glucuronide and identification of urinary metabolites of nalorphine in rabbits.


An neutral proteinase obtained from Streptomyces griseolus.


Neutral proteinases produced by Streptomyces cacaoi var. asoensis.


Reversible audiogenic seizure susceptibility induced by hyperbaric oxygenation.


Metabolism of prostaglandin E in dog kidneys. 1. The biotransformation of prostaglandin E(1) (PGE(1)) was studied in the isolated, perfused dog kidneys.2. An average 43% of PGE(1) was converted into the less polar metabolite I by a single passage through the kidney. As the re-circulation of the perfusate continued, PGE(1) was converted not only into metabolite I but also the least polar metabolite II. The velocity of the conversion of PGE(1) into metabolite I was significantly greater than that into metabolite II. Usually, six passages elapsed before maximum degradation of PGE(1) occurred.3. Further separation with silicic acid column chromatography and gas-liquid chromatography showed that metabolite II consists of two individual metabolites, metabolite IIa and metabolite IIb.4. The present study indicates that the kidney biotransforms PGE(1) rather rapidly into three metabolites which are less polar than PGE(1).


Myelination and the development of function in immature pyramidal tract.


Motor-sensory and visual behavior after hemispherectomy in newborn and mature rats.


Memory consolidations in rats with sulfide-loaded hippocampal zinc-rich synapses.


Trophic influence of in vivo transplanted sensory neurons on taste buds.


Effects of chlorpromazine on convulsive responses in developing rats.


Ultrastructure of experimentally produced globoid cells in the rat.


Neuronal activity evoked in cat precruciate cerebral cortex by cutaneous stimulation.


Choice bias from unilateral hippocampal or frontal lesions in the rat.


The metabolism and excretion of black PN in the rat and man.


Safety evaluation of yeast grown on hydrocarbons. II. One-year feeding study in rats with yeast grown on pure n-paraffins.


Myotoxicity of amine metabolites from Brown FK.


The formation of aflatoxins B2a and G2a and their degradation products during the in vitro detoxification of aflatoxin by livers of certain avian and mammalian species.


Food wrappings--a legislative dilemma.

Food wrappings--a legislative dilemma.


The place of enzyme assays in toxicology.


An experimental study of subcortical projections of the nucleus ventralis anterior in the cat.


The distribution of 3H-noradrenaline and acetylcholinesterase (AChE) proximal to constrictions of hypogastric and splenic nerves in the cat.


Cytokinetics of neonatal brain cell development in rats as studied by the 'complete 3H-thymidine labelling' method.


The range and power of ulnar and radial deviation of the fingers.


The longitudinal division of fibres in overloaded rat skeletal muscle.


Maxillary development and growth: the septo-premaxillary ligament.


An analysis of self-differentiation of chick limb buds in chorio-allantoic grafts.


Some electron microscope observations on the mesenchymal structures of full-term umbilical cord.


Mucosal architecture and epithelial cell production rate in the small intestine of the albino rat.


Trigeminothalamic fibre connexions in the dog and the pig. An experimental study with the retrograde cell degeneration method.


Destruction and regeneration of skeletal muscle after treatment with a local anaesthetic, bupivacaine (Marcaine).


Effect of methylmalonyl coenzyme A, a metabolite which accumulates in vitamin B 12 deficiency, on fatty acid synthesis.


On the subcellular location of vitamin D metabolites in intestine.


Intranuclear metabolism of progesterone-1,2-3H in the hen oviduct.


Stereospecific hydration of the delta-9 double bond of oleic acid.


Enzymatic conversion of linoleic acid to 10D-hydroxy-delta 12-cis-octadecenoic acid.


Stereospecific hydration of cis- and trans-9,10-epoxyoctadecanoic acids.


The structural properties of spinach leaf glyoxylic acid reductase.


The chromatographic determination of cystine and cysteine residues in proteins as s-beta-(4-pyridylethyl)cysteine.


Sulfhydryl studies of spinach leaf glyoxylic acid reductase.


Some kinetic properties of liver pyruvate kinase (type L). 3. Effect of monovalent cations on its allosteric behavior.


Synthesis of deoxyribonucleic acid by isolated liver nuclei.


Interconversion of isoenzymes of Drosophila alcohol dehydrogenase. II. Physical characterization of the enzyme and its subunits.


Membranes of animal cells. VI. The glycolipids of the L cell and its surface membrane.


Mannosyl transfer in Cryptococcus laurentii.


The inhibition of ferroxidase by trivalent and other metal ions.


Sugar transport in Neurospora crassa. II. A second glucose transport system.


Studies of migrant populations.

Studies of migrant populations.


Role of migrant populations in studies of environmental effects.


Some intercountry and intergroup differences in histological types of cancer.


Opportunities for studies of cardio-respiratory diseases in migrants.


Bronchitis in the United Kingdom and the United States of America.


Sources of demographic data on migrant groups for epidemiological studies of chronic diseases.


Health statistics and record linkage in Australia.


Identification of migrants and their descendents in the United States.


Ascertainment of men of Japanese ancestry in Hawaii through World War II Selective Service registration.


Some problems related to the use of mail questionnaires.


A study of disease in migrants and their siblings: development of sibling rosters.


The predictive value of a postal questionnaire on cardio-respiratory symptoms.


Differenital mortality from cardiovascular disease in migrants from England and Wales, Scotland and Italy, and native-born Australians.


A study of nasopharyngeal cancer among Singapore Chinese with special reference to migrant status and specific community (dialect group).


A glass density method utilizing marker dyes and stains.


Liver cancer differentials in immigrant and local-born Chinese in Singapore.


Intravenous amphetamine poisoning. Report of three cases.


The restoration of desiccated cadaveric fingers for the purpose of identification.


The identification of motor body fillers.


Comparison of PVC coated samples of copper cable by neutron activation analysis.


Investigation of methemoglobinemic and carcinogenic poisons as pi complexes with 2, 4, 6-trinitroanisole and picramide.


A case of poisoning by Epsom salt.

A case of poisoning by Epsom salt.


The examination of bloodstains by Laurell electrophoresis (antigen-antibody crossed electrophoresis).


Psychotropic drugs and the metabolism of intracerebrally injected tryptamine, 5-hydroxytryptamine, and norepinephrine.


Further studies on the effects of blocking agents on protein synthesis in goldfish brain.


Reduction of level of L-glutamic acid decarboxylase by gamma-aminobutyric acid in mouse brain.


Alcohol dehydrogenase activity in rat brain and liver.


The effect of gamma-aminobutyric acid on brain normetanephrine.


Preparation, properties and fractionation of the nuclear deoxyribonucleic acid from guinea pig brain.


Gravimetric estimation of myelin protein.


Role of environment in developmental models.


Gas chromatographic evaluation of the influence of oxotremorine upon the regional distribution of acetylcholine in rat brain.


Independent activity of catalase haematins.


Sliding filament model of muscular contraction. V. Isometric force and interfilament spacing.


Solute transfer between intramolecular polar and non-polar phases as a possible rate-limiting step in chymotrypsin deacylation.


Aminoacyl-transfer RNA synthetase recognition cod-words in yeast transfer RNA's: a proposal.


ART and the ribosome: a preliminary report on the three-dimensional structure of individual ribosomes determined by an algebraic reconstruction technique.


Algebraic reconstruction techniques (ART) for three-dimensional electron microscopy and x-ray photography.


Correlative relationship of cholesterol and sphingomyelin in cell membranes.


The effect of some hallucinogenic drugs on the amino acid precursors of brain monoamines.


The effects of temperature on the retention of photic habituation in the earthworm.


Identification and renal excretion of probenecid metabolites in man.


The effect of norepinephrine and insulin on brown fat cell membrane potentials.


Ribonuclese activity in the lens during differentiaion.


Metabolism of dodecyl sulphate in the rat: non-enzymic liberation of sulphate and gamma-butyroactone from the major metabolite, butyric acid 4-sulphate.


Low dosage proteases, clotting factors, capillary permeability and cellular viability.


The juvenile hormone of the giant silk moth Hyalophor gloveri (Strecker).


Association of bromide with the synaptosomal fraction of mouse brain.


In vivo production of piperidine from pipecolic acid in the rat.


Lysosomal hydrolases as glycoproteins.

Lysosomal hydrolases as glycoproteins.


Non-random differences in the base composition of chloroplas and cytoplasmic ribosomal RNA from some higher plants.


The effect of diet on the diurnal variation of cholesterol synthesis in rat liver.


Melanotic progonoma (retinoblastoma) of maxilla. Case report.


Cephalometric study of maxillary growth five years after alveolar bone grafting of cleft palate infants.


Modification of the Strömbeck technique.


Studies on the revascularization of tendons grafted by the silicone rod technique.


A cross-helix flap for ear reconstruction.


The problem of the controlled experiment.


Retarded metamorphosis in larvae of Ascaridia galli following repeated challenge of poultry with infective eggs.


Intercomparisons of absorbed dose in cobalt 60 teletherapy using mailed LiF dosimeters. II. Results for Canada and six Asian countries.


Objective procedure of constructing stages in cancer. Its application in recurrent carcinoma of the corpus uteri.


Pathologic effects of different doses of radiostrontium in mice. Changes in the haematopoietic system.


Electron beam depth dose distribution evaluation.


Kilovoltage calibration of diagnostic roentgen ray generators.


Dispersed cell cultures of rheumatoid synovial membrane.


Dose measurements in oesophagus in cobalt 60 rotation therapy.


Comparative study of distribution of injected zinc 65 in the mandibular condyle and other tissues in rat as determined by gamma scintillation.


Technetium-99m in the study of rheumatic joints.


The prevalence of rheumatoid arthritis in different geographical areas in Sweden.


Electrodiagnostic investigation of the neuro-muscular lesions in rheumatoid arthritis.


Alpha-mannosidase activity in synovial fluid.


Scanning electron microsopic studies of extensor tendon degeneration in rheumatoid arthritis.


Natural resistance to plague: genetic basis in the vole (Microtus californicus).


Renal function in urinary schistosomiasis.


Nasal leech infestation in man.

Nasal leech infestation in man.


Uptake of 59Fe as a tool for study of the crowding effect in Biomphalaria glabrata.


Population dynamics of aquatic snails in three farm ponds of Puerto Rico.


Control of Biomphalaria glabrata in a small reservoir by fluctuation of the water level.


Treatment of Paragonimus westermani infections with bithionol.


Induction of an interferon-like inhibitor by Trypanosoma cruzi infection in mice.


Nonspecific phagocytic activity in rats infected with Plasmodium berghei and treated with amodiaquine or chloroquine.


An evaluation of diagnostic tests for hydatid disease.


Tropical eosinophilia in the Republic of South Vietnam.


Pathologic effects of schistosomiasis in Ibadan, Western State of Nigeria. I. Incidence and intensity of infection; distribution and severity of lesions.


Accelerated amino acid analysis: studies on the use of lithium citrate buffers and the effect of n-propanol, in the analysis of physiological fluids and protein hydrolyzates.


Comparison of formation of granulomata around eggs of Schistosoma mansoni in the mouse, guinea pig, rat, and hamster.


An improved urease electrode.

An improved urease electrode.


Separation and identification of dipeptides by paper and column chromatography.


Liquid scintillation counting of RNA: a simple procedure for extraction from sucrose gradients.


Gas-liquid chromatographic determination of products from the progoitrins in crambe and rapeseed meals.


The 2-keto-3-deoxy-6-phosphogluconic aldolase catalyzed pyruvate-proton exchange reaction: enzymic synthesis of crystalline sodium 3H-pyruvate.


Rapid graphic methods for the estimation of enzyme normalities and their ligand dissociation constants.


Separation of 14C-formate from CO2 fixation metabolites by isoionic-exchange chromatography.


Optimum working range for the study of hemoproteins by reflectance spectroscopy.


Precise quantitative determination of human blood lipids by thin-layer and triethylaminoethylcellulose column chromatography. I. Erythrocyte lipids.


A simple radioassay of acetate thiokinase.


Precise quantitative determination of human blood lipids by thin-layer and triethylaminoethylcellulose column chromatography. II. Plasma lipids.


A protein sequencing device of simple construction.


Method for the assay of ethanol and other aliphatic alcohols applicable to tissue homogenates and possessing a sensitivity of 1 microgram-ml.


Double-isotope derivative assay of serum iodothyronines. II. Thyroxine.


Estimation of metabolites of pyrrolizidine alkaloids in animal tissues.


Behavior of ampholines during isoelectric focusing.


Mechanical fractionation of polyacrylamide gel slabs.


Effect of hemoglobin on ferricyanide-dependent assays.


Sandwich dialysis.

Sandwich dialysis.


Separation of sulfated nucleotides using polyacrylamide gel electrophoresis.


Simple technique for a stoichiometric study of metachromatic complexes of basic and acid dyes.


The influence of embryonic bursectomy on the humoral immunologic response.


Morphology of bacteriophages used for typing Shigella flexneri.


Ontogenesis of enzyme activities in the sera of animals. I. Acid phosphatase in the blood serum of rabbits.


Ontogenesis of enzyme activities in the sera of animals. II. Alkaline phosphatase in the blood serum of rabbits.


Thyroid antibodies in endemic goiter in lower Silesia studied in a sample of the population in 1969.


Antitumor properties of 1,3-oxazine derivatives. I. Derivatives of 5-nitrotetrahydro-1,3-oxazines.


Plasma or patient, paper electrophoresis or physician? the four-P problem in classification of hyperlipidaemia.


Lipid effects of a phenolic ether (Su-13437) in the rat: comparison with CPIB.


Serum lipid responses to ethyl-p-chlorophenoxyiso-butyrate in rats on different carbohydrate diets.


Thiamine content of human arterial and venous tissue.


Purified contact activation product of the coagulation system in experimental thrombosis.


Incorporation of different fatty acids into combined lipids in rabbit atherosclerotic lesions.


Circadian periodicity of the urine 17-hydroxycorticosteroid level in atherosclerosis and hypertension.


Experimental atherosclerosis induced by mechanical trauma in rats.


A comparison of free amino acids in the plasma and in the aortic wall.


Spontaneous aortic arteriosclerosis in rabbits of the Danish Country strain.


Serum protein bound carbohydrates in ischaemic heart disease and coronary risk group.


Characterization of lipoprotein lipase activity eluted from human adipose tissue.


The effect of (--)N-(alpha-phenyl-beta-(p-tolyl)ethyl) linoleamide on experimental atherosclerosis in rabbits.


Effect of different doses of vitamin D on serum cholesterol and triglyceride levels in healthy men.


Sulphydryl dependence of arterial lecithin: cholesterol transacylase.


Comparative serological studies of the T, Tn and Cad receptors.


Effects of cyclophosphamide on the ultrastructure of Peyer's patches.


The ultrastructure of platelet pseudopodia and the adhesion of homologous platelets to tumour cells.


Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats.


Partial renal papillectomy and the study of drug induced renal papillary necrosis in the rat.


A cytotoxic factor in cholera toxin.

A cytotoxic factor in cholera toxin.


Physiological studies on blood bradykininogen utilization in man.


The composition of lung lipids after poisoning with paraquat.


The long term fibrogenic effects of chrysotile and crocidolite asbestos dust injected into the pleural cavity of experimental animals.


The in vivo localization of porphyrins.

The in vivo localization of porphyrins.


Distribution of syphilitic antibodies in gel-filtered serum fractions.


Penicilloyl-polylysine intradermal testing for penicillin hypersensitivity.


Association of threads in the urine with non-gonococcal urethritis and prostatitis.


Gonorrhoea study, 1969. British Cooperative Clinical Group.


Primary and secondary syphilis. Country of origin study, 1969. British Cooperative Clinical Group.


Contact-tracing in gonorrhoea.

Contact-tracing in gonorrhoea.


New perspectives in psychosomatic medicine.


Gonorrhoea in Edinburgh.

Gonorrhoea in Edinburgh.


Sudden death and the 'medical model' in psychiatry.


Psychosocial influences on a metabolic process: the psychophysiology of lipid mobilization.


The psychoanalytic relationship as a corrective model for all medical relationships.


The abuse of abreaction: an unhappy legacy of Freud's cathartic method.


Research in a behavioural science.

Research in a behavioural science.


A behavioural science course in the first year of medical school.


The growth and development of behavioural science in medical education.


Prospects in postgraduate education in psychiatry.


Training in brief individual psychotherapy.


Recent trends in child psychiatry.

Recent trends in child psychiatry.


Some trends in geriatric psychiatry.

Some trends in geriatric psychiatry.


The mental hospital and its links to community systems.


Clinical applications of isoenzymes.

Clinical applications of isoenzymes.


Pediatric xylose absorption test: measurements in blood preferable to measurements in urine.


Automated simultaneous determination of p-acetylaminohippurate and inulin in serum.


Computer calculation of serum protein electrophoresis, based on peak height measurements.


Semiautomated method for measurement of dopa in plasma.


Plasma vitamin A assay by fluorometry and use of a silicic acid column technique.


A discussion of the linearity between the measured voltages of ion-selective electrodes and the ionic concentrations in whole blood.


Amphetamines in human urine: rapid estimation by gas-liquid chromatography.


Quality control in the Astrup method for determining acid-base parameters in blood.


Estimating aberrant homeostasis: variance in serum calcium concentration as an aid in diagnosis of hyperparathyroidism.


Emergency screening of urine, plasma, or gastric contents for barbiturates.


Normal ranges and gaussian distributions.


Urinary ammonium and pH in children.

Urinary ammonium and pH in children.


A new sensitive method for the determination of serum carnosinase activity using l-carnosine-[I-14C] beta-alanyl as substrate.


Detection of blood in faeces.

Detection of blood in faeces.


The gas-liquid chromatography of hydroxyamylobarbitone in plasma and urine.


Biochemical normals in Nigerians with particular reference to electrolytes and urea.


Quantitative estimation of diphenylhydantoin, primidone and phenobarbital in plasma by gas-liquid chromatography.


Determination of potassium ion concentration in serum using a highly selective liquid-membrane electrode.


An evaluation of the spectrophotometric determination of HbO2, and Hb in blood with the co-oximeter IL 182.


Displacement of albumin-bound bilirubin by free fatty acids. Implications for neonatal hyperbilirubinemia.


Differential determination of glucosamine, galactosamine, and mannosamine in glycopeptides derived from brain tissue glycoproteins.


Biosynthesis of glyceryl triphytanate in rabbit receiving a diet enriche with phytol.


L-homoarginine; an inhibitor of serum "bone and liver" alkaline phosphatase.


Oxalate in urine.

Oxalate in urine.


Electrophoretic separation of lipoproteins.


Ipsilateral versus contralateral extinction in dichotic listening resulting from hemisphere lesions.


A cross-modal investigation of spatial performances in patients with unilateral cerebral disease.


Some effects of stimulus presentation rate and complexity on perception and retention in brain-damaged patients.


Learning a vibrotactile code at five different loci.


Intellectual function 14 years after frontal lobe surgery.


Neuropsychological changes associated with carotid endarterectomy.


Thyroid crisis after extrathyroid surgery in previously unrecognised hyperthyroidism. A report of 2 cases.


Kinetics of cellulase inactivation by melanin.


The rôle of transketolase functional groups oxidized on enzyme photoinactivation.


Chitinase of Streptomyces sp: purification and properties.


The effects of methylmalonyl CoA on the enzymes of fatty acid biosynthesis.


Dextran applied in vivo as a primer of the phosphorylase histochemical reaction.


Cytogenetic studies on mid-trimester abortuses.


Associations between leprosy and serum protein groups.


Phenylthiocarbamide taste thresholds in the population of Thailand.


Glucose-6-phosphate dehydrogenase in the population of Northern Thailand: evidence for two common electrophoretic variants with deficient enzyme activity.


Polish variant of glucose-6-phosphate dehydrogenase (G-6-PD Lublin).


A psychoanalytic classification of character pathology.


Two contrasting types of adolescent depression and their treatment.


Snout-hand behavior in an adult patient.


Object-specific superego responses.

Object-specific superego responses.


The Oedipus myth, adolescence, and the succession of generations.


Development and segmentation of visually controlled movement by selective exposure during rearing.


Pulmonary embolectomy during pregnancy.

Pulmonary embolectomy during pregnancy.


Cardiovascular heterografts.

Cardiovascular heterografts.


Exposure requirements for developing the triggered component of the visual-placing response.


Conditioned suppression taste thresholds in the rat.


Mitral commissurotomy. Results in 1700 cases.


Chronic fear and ulcers in rats as a function of the unpredictability of safety.


Classical conditioning and instrumental learning of cardiac and gastrointestinal responses following removal of neocortex in the rat.


Sequelae of ruptured congenital aneurysms of the sinus of Valsalva.


Physiological control of hypothalamically elicited feeding and drinking.


Spontaneous rupture of the superficial femoral artery with formation of a false aneurysm.


Comparison of drinking elicited by eserine or DFP injected into preoptic area of rat brain.


Sodium appetite in rats after apparent recovery from acute sodium deficiency.


Distal arterial reconstruction (tibial and peroneal arteries) for lower limb ischemia.


Vascular trauma in Vietnam.

Vascular trauma in Vietnam.


Iliac compression syndrome. Report of ten cases.


Weight, sex, and the eating behavior of human newborns.


Effects of hippocampal lesions on cue utilization in spatial discrimination in rats.


Exploration in the hippocampal-ablated albino rat.


Effect of septal lesions on the acquisition of two types of active-avoidance behavior in rats.


Lesions in the nuclei accumbens septi of the rat: behavioral and neurochemical effects.


A radioautographic analysis of the migration and fate of cells derived from the occipital somites in the chick embryo with specific reference to the development of the hypoglossal musculature.


Is the presumptive notochord responsible for somite genesis in the chick?


Congenital hypoplasia of the iliofemoral artery.


The origin and movement of prelung cells in the chick embryo as determined by radioautographic mapping.


The lateral line system at metamorphosis in Xenopus laevis (Daudin).


Stimulation of cell division in pronephros of embryonic grafts following partial nephrectomy in the host (Xenopus laevis).


Thymus dysgenesis in nude (nu nu) mice.

Thymus dysgenesis in nude (nu nu) mice.


A model for the coarse structure of paramyosin filaments.


Conformation of single-stranded polynucleotides: small-angle x-ray scattering and spectroscopic study of polyribocytidylic acid in water and in water-alcohol solutions.


Reduction of ribosomal RNA synthesis and ribosomal RNA genes in a mutant of Xenopus laevis which organizes only a partial nucleolus. II. The number of ribosomal RNA genes in animals of different nucleolar types.


Gene expression in bacteriophage lambda. II. Regulation of RNA synthesis in vivo by the N protein.


Structure of the DNA of bacteriophage phiX174. VII. Methylation.


Structural proteins of bacteriophage T4.


Comparative studies on mitochondrial and cytoplasmic ribosomes of Tetrahymena pyriformis.


In vitro studies with rifampicin on the stability of heart mitochondrial RNA.


An X-ray diffraction study of reconstituted straight Salmonella flagella.


Simulation of the kinetics of 14C in the Krebs cycle in liver and its applicatio to the design of experiments.


Effect of varying temperature and pH upon the predicted rate of "CO2" utilization by carboxylases.


Stability of steady distributions of asocial populations dispersing in one dimension.


triping and the pattern of melanocyte cells in chimaeric mice.


A test for comparing diversities based on the Shannon formula.


Note on asocial populations dispersing in two dimensions.


Generalized solution to linear, to-compartment, open model for drug distribution.


Nicotine-induced restoration of action potentials to cardiac tissue depolarized by potassium.


Characteristics of driving of units in the sensorimotor cortex by center median nucleus and its inhibition by entopeduncular nucleus.


Rapid elevation of biogenic amine metabolites in human CSF following probenecid.


The effect of a psychotomimetic glycolate and its antidote eserine on the ACh content of the lobster walking leg nerve.


Toxoplasma.

Toxoplasma.


Aid for developing countries.

Aid for developing countries.


The syndrome of barbiturate dependence.

The syndrome of barbiturate dependence.


Drug dependence in Brisbane.

Drug dependence in Brisbane.


A review of young epileptic patients in a sheltered environment.


Methods of suicide in Western Australia.


Vibration disease: report of an early Australian case with discussion.


Commentary of electoral methods that may be used for election of committees of professional associations.


Toxoplasmosis.

Toxoplasmosis.


Fully supervised intermittent chemotherapy in tuberculosis.


Amitryptiline and cardiac disease.

Amitryptiline and cardiac disease.


Focus on medical computer development.

Focus on medical computer development.


Problems in the diagnosis and management of skeletal tuberculosis.


Intermittent chemotherapy in the Northern Territory of Australia.


Some findings on the post-mortem association of right ventricular wall thickness and chronic obstructive bronchitis, pneumoconiosis, emphysema and tuberculosis.


Alcoholism and tuberculosis in Victoria.


The effect of "Parenabol" on patients with osteoporosis.


The sequelae of small intestinal resection. The homoeostatic role of the terminal ileum.


Lead encephalopathy in children. Uncommon clinical aspects.


A process method of teaching and learning for community medicine.


The research coordination committee of the Territory of Papua and New Guinea.


Adjustment to change.

Adjustment to change.


Introduction: the purpose of research.

Introduction: the purpose of research.


The physiotherapist and research.

The physiotherapist and research.


A study into a report on cold therapy.

A study into a report on cold therapy.


Physiotherapy at the IXth British Commonwealth Games.


Surgery of the pneumatic mastoid.

Surgery of the pneumatic mastoid.


Are newborn auditory responses prognostic of deafness?


Sudden cardiac arrest in adenotonsillectomy.


Tonsillectomy and adenoidectomy: mortality and morbidity.


The identification of congenital deafness.


Some problems in neonatal screening.

Some problems in neonatal screening.


Symposium: conservation of hearing through neonatal testing. Summary.


Orbital implants.

Orbital implants.


Color enhancement of brain and orbital scans in proptosis.


Evoked response audiometry.

Evoked response audiometry.


Automatic objective refraction. Report of a clinical trial.


Marginal (ring) corneal ulcer as presenting manifestation of Wegener's granuloma. A clinicopathologic study.


Sub-tenon steroid injection for optic neuritis.


A scleral patch for exposed implants.

A scleral patch for exposed implants.


The fused orbital implant. Five years' experience.


Fitting the prosthesis: a challenge.

Fitting the prosthesis: a challenge.


The extruded implant.

The extruded implant.


The Tween 80 hydrolyzing activity of certain species of Nocardia.


Methodology in the collection of food consumption data.


Atherosclerosis of coronary arteries in some geographical regions in the Soviet Union.


Coronary artery disease opening remarks.


Risk factors in coronary heart disease.

Risk factors in coronary heart disease.


Platelet surface activation and aggregation in myocardial infarction--electron microscopic observations.


Coronary arteriography radiologic aspects.


Coronary arteriography. Clinical aspects.


Anticoagulant therapy in coronary disease.


Fibrinolytic treatment of acute myocardial infarction. A preliminary report.


Coronary ostium outside the aortic sinus. A factor in the aetiology of ischaemic heart disease?


The role of endothelial injury in arterial thrombosis and atherogenesis.


Occurrence of coronary occlusion in cases of coronary death and accidental death.


Steroid sulphates in plasma from pregnant women with pruritus and elevated plasma bile acid levels.


Quantitative studies on the excretion of glucuronide and mono- and disulphate conjugates of neutral steroids in human bile.


Detection of changes in human cholesterol metabolism.


The adventures of one thousand and one obstetrical patients assessed by oestriol excretion.


Sulphates of pregnanolones, pregnanediols and 16-hydroxysteroids in plasma from pregnant women.


Metabolic studies on sialic acid-free haptoglobin.


A search for antitumor compounds. 8. Biologic studies. Antitumor properties of 17 new 1-nitro-9-aminoacridine derivatives.


1-alpha- and 1-beta-naphthyl-5,5- diallylbarbituric acids and their hydration products.


Immunoelectrophoretic analysis (IEA) of bull semen plasma (BSP).


Specific cytotoxic effect of 6-hydroxydopamine on sympathetic neuroblasts.


Dissociation of presynaptic and postsynaptic effects produced in the lumbar cord by vestibular volleys.


The responses of lateral geniculate neurons to flashes of light during the sleep-waking cycle.