Pregnancy following coital-induced ovulation in a spontaneous ovulator. Ovulation induced in the immature rat by pregnant mare's serum can be prevented by chlorpromazine. Coitus induces ovulation in such animals, and ovulation so induced may result in pregnancy. Both implantation and pregnancy appear to be normal although the duration of gestation may be prolonged. Decidual response also is produced in the immature rat after coitus-induced ovulation. We suggest that the reflex release of luteinizing hormone may occur in Primates after coitus.


Auditory sense in certain sphingid moths. Moths of the genus Celerio, hovering and feeding from blossoms, have been observed to react vigorously to high-pitched sounds. The acoustic receptor appears to involve the labial palps. Its characteristics have been determined from responses made, when the moth is exposed to artificial sound pulses, by an interneuron originating in its head. These responses have been found only in 4 out of 19 sphingid species tested.


Focal hepatic injury and repair produced by laser radiation. Pathologic and biophysical studies.


Cerebral intraventricular hemorrhage and subependymal matrix infarction in the fetus and premature newborn.


Steroid-induced hypertension in the rat. A microangiographic and histologic study on the pathogenesis of hypertensive vascular and glomerular lesions.


Regeneration of the mammalian liver. VI. Retention of phenobarbital-induced cytoplasmic alterations in dividing hepatocytes.


The production and passive transfer of allergic adrenalitis.


Experimental toxic cirrhosis in the rat. II. Kinetics of hepatocyte proliferation during intermittent thioacetamide intoxication.


Effect of alterations in shortening and external work on oxygen consumption of cat papillary muscle.


Hepatic changes produced by a single dose of endotoxin in the germfree mouse. Histochemistry, light microscopy, fluorescence microscopy, and electron microscopy.


Origin of the pulmonary venous flow pulse.


Estimated heat contribution of brown fat in arousing ground squirrels (Citellus lateralis).


Changes in rat ventral caudal nerve conduction velocity during cold exposure.


Biliary capacity in rats following ethionine ingestion.


Adrenal and thyroid function in stress-susceptible pigs (Sus domesticus).


Function, substrate supply, and metabolic content of rabbit heart perfused in situ.


Superior colliculus-evoked response in anesthetized cats: space-time characteristics.


Adenohypophysial DNA and RNA after adrenalectomy, castration, and PTU.


Daily fluctuation (circadian and ultradian) in biogenic amines of the rat brain.


Lecithin-lysolecithin cycle in the toad bladder.


Albumin catabolism in rabbits injected with rabbit albumin or polyvinylpyrrolidone.


Renal function and blood chemistry in Cetacea.


Effects of potassium ferricyanide on the electroencephalogram of isolated toad brain.


Pressor activity of renal venous effluent following constriction of renal artery in dogs.


QRS-T variations in the rat electrocardiogram.


P-R interval of the rat electrocardiogram.


Role of the sympathicoadrenal system in the hemodynamic response to exercise in dogs.


Serum enzyme and tissue changes in rats exercised repeatedly at altitude: effects of training.


Cardiac response of starlings to sound: effects of lighting and grouping.


Autohemolysis and osmotic fragility of macrocytic erythrocytes produced in response to hemolysis.


Effect of expansion of the extracellular space on the rate of urinary excretion of calcium.


Uptake of amino acids by the human platelet.


Comparison of sympathetic vasodilator innervation of hindlimb of the dog and cat.


Adaptive changes in alpha-glycerophosphate-generating enzymes in rat liver.


Effects of actinomycin D and hypophysectomy on development of myocardial hypertrophy in the rat.


Stop-flow analysis of bile secretion.

Stop-flow analysis of bile secretion.


Oxygen cost of thermal panting.

Oxygen cost of thermal panting.


Spark source mass spectrographic analysis of tobacco ash.


Rapid procedure for the chloroacetylation of microgram quantities of phenols and detection by electron-capture gas chromatography.


Gas chromatographic microestimation of acetylcholine and related compounds.


An automatic group separation system  for the simultaneous determination of a great number of elements in biological material.


Homovanillic acid as a fluorometric substrate for oxidative enzymes. Analytical applications of the peroxidase, glucose oxidase, and xanthine oxidase systems.


Effect of silicone grease on diffusion of fluoride.


Simultaneous determination of iron-55 and stable iron by liquid scintillation counting.


Spectrophotometric determination of hydrogen peroxide in aqueous media with 1,2-di-(4-pyridyl)ethylene.


The contribution of analytical chemistry to the genetic revolution.


A technique for increasing the solvent properties in proton magnetic resonance spectrometry.


A simple, sensitive, and specific colorimetric assay for dihydroxyurea.


The determination of calcium and magnesium in acetylene flames.


Estimation of partial pressure of halothane in blood.


The determination of lidocaine and prilocaine in whole blood by gas chromatography.


Inhibition of succinylcholine-induced increased intraocular pressure by non-depolarizing muscle relaxants.


Spinal epidural hematoma following continuous epidural anesthesia.


Hematocrit values at various sites in man.


Deliberate hypotension for the management of threatening hemorrhage.


Appraisal of the Hook and Tucker halothane meter.


Thermal burns caused by warming blankets in the operating room.


The effects of gamma radiation on halothane.


Neuromuscular block with succinylcholine and decamethonium.


Hemodynamic and radiological evaluation of patients with hepatic or pancreatic disease by combined umbilico-portal and systemic venous catheterization.


Upper lung lobe fibrosis in ankylosing spondylitis.


Active pulmonary tuberculosis in a large general hospital.


Metastatic neoplasms of the brain stem.

Metastatic neoplasms of the brain stem.


The use of broadcast television in continuing medical education.


Inclusion cyst of the myocardium in a patient with complete heart block.


Screening for disease.

Screening for disease.


Neuropsychiatric aspects of hypokalemia.


Retrocaval ureter.

Retrocaval ureter.


The language barrier in medical communication.


On the use of phosphor-teflon thermoluminescent dosimeters in health physics.


Renal papillary necrosis and abuse of analgesics.


Tritium film badge.

Tritium film badge.


The effects of halothane and cyclopropane on skeletal muscle vessels and baroreceptor reflexes.


A comparison of lithium fluoride and film for personnel dosimetry.


Some views on film dosimetry.

Some views on film dosimetry.


A trustee views the voluntary hospital system.


Computer speeds reporting of laboratory test results.


Evaluation of endotracheal steroid therapy in acid pulmonary aspiration syndrome (Mendelson's syndrome).


Early detection of inhospital epidemics.


Nerve impulse conduction during intravenous lidocaine injection.


Graduates and preceptors evaluate hospital personnel internship program.


The effects of hexafluorenium in preventing the increase in intraocular pressure produced by succinylcholine.


Cardiovascular and respiratory effects of subarachnoid block in the presence of acute blood loss.


Non-adrenergic vasoconstriction produced by halothane and cyclopropane anesthesia.


Life safety code protects liver, not just buildings.


Disposable vs. reusable linen in the nursery--results of a comparative study.


Purifying water for special hospital uses.


Pulmonary function following percutaneous cervical cordotomy.


Concerning experimental results.

Concerning experimental results.


Food service and dietetics. Calculating cost of labor versus cost of laborsaving machines.


Considerations for menu planning in hospitals.


University, hospital benefit from intern program.


Purine nucleosides. 18. The direct utilization of unsaturated sugars in nucleoside syntheses. The conformation and structure of certain 9-(2-deoxyribopyranosyl)purines prepared from D-arabinal.


Estimation of particle dimensions from the relaxation of transient electric birefringence of suspensions.


The radiation chemistry of biochemical disulfides. I. The low-dose x-radiolysis of cystine.


The elastase-catalyzed hydrolysis of p-nitrophenyl trimethylacetate.


Clinical staff and hospital prestige.

Clinical staff and hospital prestige.


Urinary epinephrine and norepinephrine during Innovar-nitrous oxide anesthesia.


The importance of a premise.

The importance of a premise.


Rectal biopsy for megacolon.

Rectal biopsy for megacolon.


A technique for placement of an internal shunt.


The nature and surgical significance of common duct stones.


Morbidity of surgical treatment for nonmalignant biliary tract disease.


Vascular factors in liver regeneration.

Vascular factors in liver regeneration.


Surgical treatment of Curling's ulcer.

Surgical treatment of Curling's ulcer.


Synthetic bypass grafts in the treatment of renal artery stenosis.


Factitial proctitis due to irradiation for cancer of the cervix uteri.


Clinical classification of carcinoma of the uterine body.


Renal metabolism following ischemia and extracorporeal perfusion with hypoxia.


Fat macroglobulinemia and fat embolism.

Fat macroglobulinemia and fat embolism.


Nonpalpable carcinoma in fibrocystic disease of the breast.


Experiences with Meckel's diverticulum.

Experiences with Meckel's diverticulum.


Respiratory distress associated with anomalies of the aortic arch.


Absorption, rotatory dispersion, and circular dichroism studies on some hydroxy and amino acids.


Stable carbonium ions. LIX. Protonated alkyl carbamates and their cleavage to protonated carbamic acids and alkylcarbonium ions.


Inhibition of neighboring-group participation by chelation. The effect of cupric ion on the solvolysis of 4(5)-(2-amino-3-bromopropyl)imidazole.


A retrospective survey of 498 patients with malignant melanoma.


The solvolysis of 4(5)-(2-amino-3-bromopropyl)imidazole.


Synthesis and polarographic reduction of strained phenanthrenequinones. The buttressing effect.


Reaction of ninhydrin with cytosine derivatives.


The crystal and molecular structure of dihydrothymine.


Synthesis of "acetone-oxytocin" from an isopropylidene derivative of S-benzyl-L-cysteinyl-L-tyrosine.


The structure of telomycin.

The structure of telomycin.


A novel method for the synthesis of cyclonucleosides. Synthesis of 8,5'-o-anhydro-8-oxyadenosine.


Serum folic acid levels in pregnancy and their relationship to megaloblastic marrow change.


Pyrrolo[2,3-d]pyrimidine nucleoside antibiotics. Total synthesis and structure of toyocamycin, unamycin B, vengicide, antibiotic E-212, and Sangivamycin (BA-90912).


Effect of vincristine on synthesis of ribonucleic acid and protein in leukaemic leucocytes.


Starch gel electrophoresis of erythrocyte membranes in hereditary spherocytosis.


The differential ferrioxamine test in rheumatoid disease, neoplastic and other haematological disorders.


The treatment of iron deficiency anaemia by iron-dextran infusion: a radio-isotope study.


Absence of intrinsic factor from human portal plasma during 57CoB12 absorption in man.


The effect of enteral and parenteral iron on ferritin synthesis in the intestinal mucosa of the rat.


Experimental iron deficiency in the rat. The use of 51Cr, DF32P and 59Fe to detect haemolysis of iron-deficient cells.


A modified total serum cholesterol method to eliminate the effect of high bilirubin levels.


Quantitative chromatographic studies on urinary amino acid excretion. A new method of representation.


Simultaneous determination of pregnanediol and pregnanolone in urinary extracts by gas chromatography.


An automated osmometer.

An automated osmometer.


A sequential sampling system for spectrophotometers.


Detection of serum alkaline phosphatase isoenzymes with phenolphthalein monophosphate following cellulose acetate electrophoresis.


Glycerol lubricant: potential source of error in commercially prepared blood specimen tubes.


Correspondence: Reference standards and substrates for alkaline phosphatase.


Obesity, cardiovascular diseases, and the dietitian.


Diets, drugs, and their interrelationships.


Planning for the nation's health.

Planning for the nation's health.


Hospital and health planning.

Hospital and health planning.


Today's opportunities for dietitians and nutritionists.


World food supply and population explosion.


Interests and activities of the Food and Nutrition Board.


Community pediatrics.

Community pediatrics.


The general medical journal in clinical medicine.


The meaning of community medicine.

The meaning of community medicine.


Hospital-acquired infections.

Hospital-acquired infections.


Infections and antibiotic use among patients at Boston City Hospital, February, 1967.


Are "infinity machines" paradoxical? Can processes involving an infinite sequence of operations or "acts" be completed in a finite time? The mathematical physicist Hermann Weyl (2) has claimed that, unless machines can accomplish an infinite sequence of distinct operations in a finite time, the standard mathematical theory of motion is beset by one of Zeno's kinematical paradoxes. Hence I have compared the kinematics of several such "infinity machines" to the kinematics of the continuous motion of Achilles. And I have argued that, while some designs for infinity machines are indeed inconsistent, others are not impossible on purely kinematical grounds. This argument was coupled with several reasons for denying Zeno's and A. N. Whitehead's allegation of paradox against the mathematical, description of the motion of Achilles.


Federal labs: White House study urges closer university ties.


Biologic effects of supernovae.

Biologic effects of supernovae. Estimates of the probability that nearby explosions of supernovae have occurred during the earth's history and the biologic effects of the radiation therefrom are presented. They suggest that cosmic radiation from supernovae could have caused the extinction of many exposed animals without the simultaneous extinction of plant life. This suggests that supernovae should be considered as one possible mechanism by which fauna become extinct.


Serial-choice reaction time: inadequacies of the information hypothesis. The results of an experiment on serial-choice reaction time, specifically designed as a critical test of the Information Hypothesis, lead to rejection of the hypothesis; information is found to be neither a necessary nor a sufficient condition to account for the data. Where previously information had been interpreted as a determinant of reaction time, it was usually confounded with the probability of nonrepetition of a signal. Thus, to the extent that this confounding is present in previous experiments, the inference attributing an increase in reaction time to an increase in information is logically invalid.


Ammonium ion concentration in the primitive ocean. If ion exchange on clay minerals regulated the cationts in the primitive ocean as it does in the present ocean, the pH would have been 8 and the K(+) concentration 0.01M. Since NH(4)(+) and K(+) are similar in their claymineral equilibria, the maximum NH(4) (+) concentration in the primitive ocean would also have been 0.01M. An estimate of the minimum NH(4)(+) concentratin is 1 x 10(-3)M, based on the reversible deamination of aspartic acid and the assumption that aspartic acid is necessary for the origin of life. The rate of this nonenzymic deamnination is rapid on the geological time scale.


Baroreceptors in the adrenal gland.

Baroreceptors in the adrenal gland. Afferent activity from dissected filaments of nerves to the adrenal gland was recorded. Firing rates of single fibers followed changes in systemic blood pressure. Chemically and mechanically induced changes in blood pressure were reflected by an appropriate directional change in unit activity.


Leukemia virus suppression of antibody-forming cells: ultrastructure of infected spleens. Infection of adult BALB/c mice with Friend disease virus results in a leukemia-like disease characterized by erythropoietic changes and splenomegaly. A marked depression of formation of cellular and serum antibody occurs in infected animals. Electron-microscopic examination of the ultrastructure of spleen sections from infected mice with depressed immunity revealed that virus particles can be detected only in immature blastlike lymphoid cells and not in plasmocytes characteristic of the immune response in spleens of noninfected mice immunized with sheep erythrocytes.


Infrared receptors in the facial pits of the Australian python Morelia spilotes. There is a series of pits in the scales of the rostrum and posterior portion of the lower lips in some pythons and boas. In the Australian python Morelia spilotes, these pits are innervated by the maxillary and mandibular branches of the trigeminal nerve. Structural and neurophysiological evidence indicate that in the pits there are receptors that function as detectors of radiant heat flux.


Premature citations and zoological nomenclature.


Cysteamine: differential x-ray protective effect on Chinese hamster cells during the cell cycle. Cysteamine present during x-irradiation protects synchronized Chinese hamster cells in culture against lethal damage at all stages of the cell cycle. The effect is greatest for cells irradiated at sensitive stages such as G(1) and least for resistant cells; for example, late S (dose-modifying factors 4.2 and 2.7, respectively). The effect of 50 millimolar cysteamine is to render almost invariant the normally variant x-ray age response for lethality. This suggests that there are two components of x-ray damage, only one of which is age dependent, and it is against this component that cysteamine protects the cell. Cystamine, however, has no protective effect upon these cells at any stage of the cell cycle.


Reinforcement reduction: a method for training ratio behavior. By use of intracranial stimulation as reinforcement, fixed-ratio performance could be established directly from continuous reinforcement by gradual reduction of the train duration of the stimuli contingent on all but the terminal response in the desired ratio. Furthermore, stimuli of subreinforcement strength enhanced ratio performance when introduced after training by the conventional method.


Skin sensory afterglows.

Skin sensory afterglows. Brief stimulation of the upper lip with the tip of a nylon thread frequently produces an " afterglow" sensation that may persist as long as several minutes after cessation of stimulation. The duration of afterglow is increased by strong suggestion, and decreased by vibration of the skin prior to stimulation. The afterglow may be followed by a period of acute "awareness" of the area, distincty different from the stimulus and afterglow sensations. The afterglows produced by a warm stimulator applied to the back often well up into a painful sting.


Serosal patch grafting for closure of posterior duodenal defects.


Familial pancreatitis.

Familial pancreatitis.


Microcirculatory dynamics in the normal and inflamed pancreas.


Angial residue hepatography versus direct transumbilical hepatography. A comparison of two new methods.


Quo vadis.

Quo vadis.


Cardiorespiratory determinants of survival in cirrhotic patients requiring surgery for portal hypertension.


Surgical exclusion of the colon for chronic hepatic encephalopathy.


Pyogenic liver abscess. Changing patterns in approach.


Patterns of distribution of sulfobromophthalein in lymph and blood during obstruction to bile flow.


How can the outlook in alimentary tract cancer be improved?


Gallstone formation in the germ-free mouse.


Experimental nonocclusive mesenteric ischemia. Therapeutic observations.


Vascular compression of the duodenum. Emphasis on accurate diagnosis.


Mistaken psychiatric referral of occult serious cardiovascular disease.


Celiac compression syndrome.

Celiac compression syndrome.


Schizophrenic hallucinations and the transcephalic DC potential.


Leukocyte glycolysis in schizophrenic patients.


"Postpartum blues" syndrome. A description and related variables.


Aims and conduct of psychotherapy.

Aims and conduct of psychotherapy.


Teaching infant development by observation. A basic child psychiatry course.


Clinical change in jail-referred mental patients.


Countertransference in milieu treatment.


Psychologic response to colectomy.

Psychologic response to colectomy.


The community meeting. An analytical study and a theoretical statement.


Dauerschlaf. A polygraphic study.

Dauerschlaf. A polygraphic study.


Hypertension in the tropics.

Hypertension in the tropics.


Ultrasonic compound B-scanning as a diagnostic tool in obstetrics and gynaecology.


Lichenoid eruption due to chlorpropamide.


Pay-beds in N.H.S. hospitals.

Pay-beds in N.H.S. hospitals.


Lead poisoning from eye cosmetic.

Lead poisoning from eye cosmetic.


Statistics on blindness.

Statistics on blindness.


Diet and diverticulitis.

Diet and diverticulitis.


Hospital medical records.

Hospital medical records.


Traveller's diarrhoea.

Traveller's diarrhoea.


Tetanus antitoxin.

Tetanus antitoxin.


Human tetanus antitoxin.

Human tetanus antitoxin.


Improving the psychiatric services.

Improving the psychiatric services.


Psychotropic drugs.

Psychotropic drugs.


Congenital dislocation of the hip.

Congenital dislocation of the hip.


Bethanidine in hypertension.

Bethanidine in hypertension.


Fibrin degradation products.

Fibrin degradation products.


Influenza and pneumonia.

Influenza and pneumonia.


Managing the hospitals.

Managing the hospitals.


Public attitudes to mental health education.


Acute gastroenteritis.

Acute gastroenteritis.


Renal pain of vascular origin.

Renal pain of vascular origin.


Revision of history.

Revision of history.


Medical factors and road accidents.

Medical factors and road accidents.


Effects of nicotine.

Effects of nicotine.


Treatment of oral lichen planus with betamethasone.


Use of lignocaine in treatment of cardiac arrhythmias.


Follow-up study of refractory obesity treated by fasting.


Absorption and secretion of water and electrolytes by the intact colon in a patient with primary aldosteronism.


Partial hydronephrosis due to pressure from normal renal arteries.


Renal amyloidosis associated with gastric carcinoma.


The impact of the American Heart Association on cardiovascular research.


Ballistocardiography: predictor of coronary heart disease.


Recognition and significance of intraventricular block due to myocardial infarction (peri-infarction block).


Observations on the blood pressure of Tibetans.


Amiloride. A potassium-sparing natriuretic agent.


Plasma volume expansion resulting from interference with adrenergic function in normal man.


Surgical correction of absence of proximal segment of left pulmonary artery.


Atrial fibrillation produced by atrial stimulation.


On the path of the excitation wave in atrial flutter.


Clinical significance of coronary artery calcification seen fluoroscopically with the image intensifier.


Pulmonary hypertension associated with cirrhosis of the liver and with portacaval shunts.


Closed chest cardiopulmonary bypass in deep hypothermia. The use of the pulmonary vasculature as left heart vent.


Effect of partial and total cardiopulmonary bypass with whole blood or hemodilution priming on pulmonary surfactant activity.


Hemodynamic effects of propranolol in coronary heart disease.


Cardiac effects of diphenylhydantoin (Dilantin) in man.


Pulmonary atresia with intact ventricular septum.


Antiarrhythmic properties of Tris (hydroxymethyl aminomethane).


Coronary artery blood flow in acute pulmonary embolism.


Propranolol and isosorbide dinitrate synergism in angina pectoris.


The responsibility of the professional society for scientific communications.


Long-term follow-up of patients with cardiac pacemakers.


Clinical course of atherosclerotic renovascular disease.


Viral antibodies in patients with primary myocardial disease.


Supravalvular tricuspid stenosis. Association with developmental abnormalities of the right heart and derivatives of the sixth aortic arch.


Synchronous diaphragmatic contraction. A complication of transvenous cardiac pacing.


Salivary gland scanning with technetium 99m pertechnetate.


High intensity proximity therapy of intraoral cancer. With description of a new after-loading unit.


Integrated irradiation and operation in treatment of cancer of the larynx and hypopharynx. A preliminary report.


Treatment of cervical lymph node metastasis from primary lesions of the oropharynx, supraglottic larynx and hypopharynx.


The role of roentgenographic studies in the evaluation and staging of malignancies of the larynx and pharynx.


The surgical treatment of cancer of the cervix: stage I and II.


Head immobilization unit in aid of head and neck tumor treatment.


Sequential radiation therapy and surgery for stage I and stage II cancer of the cervix.


Management of stage I and II adenocarcinomas of the uterine cervix on intact uterus.


Persistent tumor cells in the vaginal smear during the first year after radiation therapy of carcinoma of the uterine cervix. Prognostic significance.


Radiotherapy following simple hysterectomy in patients with stage I and II carcinoma of the cervix.


A new afterloading technique for interstitial irradiation using radioactive microspheres.


Field separation in multiple portal radiation therapy.


"Fractional life expectancy" as a new index for analyzing the results of radiotherapy.


Photographic technique for leak testing radium sources.


Radiation dose-tumor control assays for irradiation through a sieve.


The light is better here.

The light is better here.


Oxygen and L-triiodothyronine in radiotherapy of mouse tumors.


Radiation sensitivity of spleen cells irradiated in vitro and in vivo.


Lethal effect and visible irradiation damage.


The relative biologic effectiveness of cobalt 60 gamma and 200 kv. X radiation for cataract induction.


Positive scintigraphy of tumor by means of intra-arterial injection of radioiodinated macroaggregated albumin (MAA).


Radioalbumin macroaggregate brain scanning. A histopathologic investigation.


Hyperbaric oxygen in radiation therapy. An investigation of dose-effect relationships in tumor response and tissue damage.


Sequential brain scanning in radiation therapy of malignant tumors of the brain.


Demonstration of the choroid plexus with technetium 99m brain scan.


Cervical mediastinal lymph node exploration for diagnosis and determination of operability.


Use of radiopaque markings on middle lobe (or lingula) following upper resectional surgery.


Surgical aspects of chronic progressive cavitary pulmonary histoplasmosis.


Traumatic aortico-right ventricular fistula. A case with delayed appearance and successful repair.


Circumferential replacement of the trachea in experimental animals.


Gynecomastia after incision on the thoracic cage.


Concomitant intrathoracic aneurysm and bronchial rupture due to trauma. Successful repair.


Infradiaphragmatic total anomalous pulmonary venous return. Report of a new and correctable variant.


Use of the internal jugular vein for implantations of permanent transvenous pacemakers. Experiences with 22 patients.


Sudden unexpected death from natural causes in young adults. A review of 275 consecutive autopsied cases.


Cytoplasmic invaginations resembling nuclear inclusions.


Residency training.

Residency training.


Radioresistance as a measure of interaction of human lymphocytes.


Lapine renomedullary lipid in murine hypertension.


Twenty years on.

Twenty years on.


Stocktaking in obstetrics.

Stocktaking in obstetrics.


Stress ulceration.

Stress ulceration.


Diffuse fibrosing alveolitis.

Diffuse fibrosing alveolitis.


Aortic valve replacement.

Aortic valve replacement.


Prescription charges.

Prescription charges.


Changing clinical picture of neurosyphilis: report of seven unusual cases.


Effects of I.C.I. 50172 in man during erect exercise.


Haemodynamic effects of I.C.I. 50172 in patients with ischaemic heart disease.


Urinary steroid values as a guide to prognosis in breast cancer.


Suppurative pericarditis complicating myocardial infarction.


Physical stimulation of the heart.

Physical stimulation of the heart.


Haemodynamic effects of balloon septostomy in tricuspid atresia.


Today's drugs verapamil.

Today's drugs verapamil.


Sternal plate for repair of pectus excavatum.


The Rathcoole experiment: first year at a hostel for vagrant alcoholics.


Mathematics, computers, and the doctor.

Mathematics, computers, and the doctor.


New general teaching hospital at Liverpool.


Comparative hospital costs.

Comparative hospital costs.


Acute gastroenteritis.

Acute gastroenteritis.


Diagnosis of pyelonephritis in children.


Urinary tract infection in infancy.

Urinary tract infection in infancy.


Renal glucose threshold.

Renal glucose threshold.


Source of pulmonary emboli.

Source of pulmonary emboli.


Psychotropic drugs.

Psychotropic drugs.


Polycythemia and chorea.

Polycythemia and chorea.


Transplant lung.

Transplant lung.


Use of epsilon aminocaproic acid.

Use of epsilon aminocaproic acid.


Rinsing the dialyzer.

Rinsing the dialyzer.


Elastic band injuries.

Elastic band injuries.


Budd-Chiari syndrome after oral contraceptives.


Real reasons for emigration.

Real reasons for emigration.


Length of menstrual cycle.

Length of menstrual cycle.


Jaundice of pregnancy.

Jaundice of pregnancy.


Personal viewpoint on anaesthesia.

Personal viewpoint on anaesthesia.


Congenital dislocation of the hip.

Congenital dislocation of the hip.


Haematemesis.

Haematemesis.


Localization of intracranial tumors.

Localization of intracranial tumors.


Prescription charges.

Prescription charges.


Carcinogenicity of tobacco and tobacco smoke.


Hospital management.

Hospital management.


Supervisors of nursing are superfluous.

Supervisors of nursing are superfluous.


Measles vaccines.

Measles vaccines.


Measles protection for 11,497.

Measles protection for 11,497.


Prenatal classes for unmarried expectant mothers.


Infection control nurse in a general hospital.


Prepared childbirth: its impact on nursing.


"I won't eat, I won't".

"I won't eat, I won't".


Cancer of the cervix in an Amish population.


Heredity and intraocular malignant melanoma. Study of two families and review of forty-five cases.


Human appendix and neoplasia.

Human appendix and neoplasia.


Multicentric chordoma. Report of a case.


Long-term survival of mother and son with widespread metastatic adenocarcinoma of colon.


Primary melanoma of the lung.

Primary melanoma of the lung.


Parabiotic transfer of tumor-specific immunity.


Cancer of human bladder. Responses of tumor xenografts to chemotherapy and radiotherapy.


Effect of mithramycin on HeLa cells.

Effect of mithramycin on HeLa cells.


Methotrexate for advanced cancer of the breast.


Occurrence of reovirus antibodies in health African children and in children with Burkitt's lymphoma.


Alterations of lesions of mycosis fungoides lymphoma by direct imposition of delayed hypersensitivity reactions.


Cancer of tongue in Connecticut, 1935-1959.


Cancer of the floor of the mouth in Connecticut, 1935-1959.


Experimental arterial dissemination of tumor cells.


Serum cholesterol and incidence of gallstones. Analysis of one-year autopsy material.


Diagnosis and treatment of postinfarction left ventricular aneurysm.


Inhibitory effect of chlorothiazide on natruretic action of mercurial diuretics.


Ulcers of the digestive tract wall in patients with myocardial infarction.


Diagnosis of venous thrombosis.

Diagnosis of venous thrombosis.


Causes of death in old age.

Causes of death in old age.


Myocardial infarction and carbohydrate metabolism.


Bone demineralization and estrogen activity after menopause.


Small bowel ulceration. An evaluation of thiazide therapy.


Treatment of the mentally disturbed geriatric patient.


Silent myocardial infarction.

Silent myocardial infarction.


Nutritional and physical factors in coronary heart disease.


Hospital-acquired infections. 1. Problems of environment.


Drug incompatibility from the standpoint of the intravenous route of drug administration.


A review of pharmacy for nurses. The oral route of administration--syrups, elixirs and tinctures.


The manufacturer's role in the liaison among central service, purchasing and manufacturers.


Selecting the proper flooring material. A guide to resilient vinyl materials.


The study of applicants, 1966-67.

The study of applicants, 1966-67.


Organization for education in the clinical fields.


The science administrator: a new profession.


General thoughts about general practice: a medical student's view of the future of general practice in the United Kingdom.


Internships in a University Department of Obstetrics-Gynecology: a comparative study.


Patient presentation at psychiatric teaching conferences.


Teaching medical students by videotape simulation.


An emergency department teaching program.


Attitudes of medical students toward mental retardation: a prelmininary study.


The Fountain Committee report.

The Fountain Committee report.


Conservation of our gross anatomy courses.


Report of an experiment in the use of telelectures for the continuing education of physicians and allied health personnel.


Introducing the community to medical students and residents: an evaluation of a field trip program.


Datagrams. Group practice by medical school faculty.


The partial synthesis of 18,19-dinor steroids.


Relative influences of electron-withdrawing functional groups on basicities of amino acid derivatives.


Structure of anisomycin.

Structure of anisomycin.


Peptide synthesis via oxidation of N-acyl-alpha-amino acid phenylhydrazides. II. Benzyloxycarbonyl peptide phenylhydrazides.


Bile acids. 23. A new direct synthesis of allocholic acid and its 3 beta isomer.


Synthesis of 1,4,5-tri-O-benzoyl-2,3-dideoxy-D-erythro-hex-2-enulopyranose, derivative of a ketose-related glycal having an endocyclic double bond.


Thio sugars. Synthesis of the adenine nucleosides of 4-thio-D-xylose and 4-thio-D-arabinose.


Indole and 4-aminoindole nucleosides.

Indole and 4-aminoindole nucleosides.


Reductive ring openings of glutarimides and barbiturates with sodium borohydride.


Thermal isomerization of ergosterol and dehydrocholesterol.


A convenient method for the synthesis of 2-fluoroadenosine.


A new isoflavone glycoside from Baptisia australis.


Nucleosides. XLVI. Selectively methylated derivatives of spongouridine.


Complexes in calcium phosphate solutions.


The cobalt-60 gamma radiolysis of cysteine in deaerated aqueous solutions at pH values between 5 and 6.


Estimation of the isomerization rate of nitrous acid.


Scientific responsibility in modern life.


Care for indigents in Bolivia.

Care for indigents in Bolivia.


How may Congress learn?

How may Congress learn?


Expansion of Idaho reservoir: Indians, scientists on warpath.


Paramutation: directed genetic change. Paramutation occurs in somatic cells and heritably alters the functional state of a locus.


American science policy: OECD publishes a massive critique.


Dense-gas chromatography of nonvolatile substances of high molecular weight. Working at pressures of up to 2000 atmospheres, more than ten times higher than in previous gas chromatography, we used the solvent power of dense gases to enable migration of chromatographic substances of molecular weights as high as 400,000. Carotenoids, corticol steroids, sterols, nucleosides, amino acids, carbohydrates, and several polymers have been caused to migrate, separated, and detected in NH(3) and CO(2) carrier gases at temperatures of 140 degrees and 40 degrees C, just above the respective critical points. Previously such compounds either defied separation by gas chromatography or had to be chromatographed as their more volatile derivatives.


Calcium carbonate concretions formed by the decomposition of organic matter. Bacterial decomposition of butterfish and smelts in small sealed jars containing seawater and other solutions, for periods ranging from 65 to 205 days, results in a large increase in concentrations of dissolved bicarbonate, carbonate, and ammonia (plus volatile amines). Accompanying this is a rise in pH and the precipitation of Ca(++) ion from solution. The Ca(++) is not precipitated as CaCO(3) but instead as a mixture of calcium fatty acid salts or soaps with from 14 to 18 carbon atoms. This can be explained by the thermodynamic instability of CaCO(3) relative to Ca soaps in the presence of excess free fatty acid. It is suggested that some ancient CaCO(3) concretions, especially those enclosing fossils of soft-bodied organisms, may have formed rapidly after death in the form of natural Ca soap (adipocere) which was later converted to CaCO(3).


Selective solubilization of a protein component of the red cell membrane. Approximately 20 percent of the membrane-bound protein of erythrocyte ghosts can be solubilized and obtained free of other membrane components by dialysis against adenosine triphosphate and 2-mercaptoethanol. This protein forms one major band on polyacrylamide gels and a single boundary in free-boundary electrophoresis, and it undergoes polymerization in the presence of divalent cations to form coiled filaments visible by electron microscopy. Antibodies to this membrane protein react specifically with red blood cells or their membrane ghosts but do not react with serum, erythrocyte cytoplasm, or other blood cells. The functional role of this protein is unknown, but it appears to be involved in maintaiining the structure of the red cell membrane. We suggest that this protein be called Spectrin since it is obtained from membrane ghosts.


Atypical cholinesterase gene E1a: rarity in Negroes and most Orientals. Development of a rapid screening test for atypical cholinesterase in serum enabled large-scale surveys of populations. The frequency of the heterozygous trait among Greeks, Yugoslavs, and East Indians was similar to that among United States Caucasians (2.8 to 3.3 percent). In trait frequency, U.S. Negroes were intermediate (1.05 percent) between Congolese Africans (0.29 percent) and U.S. Whites (3.3 percent). The gene was absent from or very rare in populations originating in East Asia (Taiwanese, Japanese, Filipinos, and Eskimos). Prolonged apnea during anesthesia from administration of succinylcholine caused by homozygosity for this gene, is expected to be extremely rare among populations of Negroes and East Asians.


Sex attractant of sugar beet wireworm: identification and biological activity. The sex attractant produced by adult females of the sugar beet wire-worm, Limonius californicus (Mannerheim) has been isolated and identified as valeric acid. In the laboratory, male wireworm beetles are repelled by the pure attractant but are drawn with intense sexual excitement to its dilute solutions; in the field, male beetles are lured from a distance of 12 meters. The pheromone occurs in unusually large amounts in the female's body.


Crystal and molecular structure of adenosine 3',5'-cyclic phosphate. The structure of adenosine 3',5'-cyclic phosphate has been determined by single-crystal x-ray diffraction. The two molecules in the asymmetric unit show different conformation about the glycosidic bond, while other structural details are essentially the same. The furanose rings are puckered with the C(4') atom out of the best four-atom plane. The bond lengths and angles appear to be normal.


Hemoglobin Hijiyama: a new fast-moving hemoglobin in a Japanese family. A variant of hemoglobin A, named Hb Hijiyama, found in two generations of a Japanese family living in Hiroshima, Japan, has a higher anodal electrophoretic mobility than hemoglobin A; a gain of two negative charges per molecule is indicated. Fingerprinting and amino acid analysis showed the biochemical anomaly to be in the beta chain at residue 120, where lysine is replaced by glutamic acid. In the heterozygote carriers of the abnormal hemoglobin there is no apparent association with clinical or hematologic abnormalities.


Protein conformation in solution: cross-linking of lysozyme. The cross-linking of lysozyme by reaction with phenol-2,4-disulfonyl chloride has been effected. The cross-linked protein retained enzymatic activity, has approximately the same molecular weight as native lysozyme, and has essentially the same conformation as native lysozyme as judged by optical rotatory dispersion analysis. The positions of sulfonylation were assigned by a standard degradation sequence; the presence of sulfonamide bonds was confirmed by infrared spectroscopy. Cross-links may thus be introduced without incurring major structural changes in the protein, and certain intramolecular distances that are allowed in the active enzyme may be deduced.


Membrane origin of the fast photovoltage of squid retina. When a bright light flash is absorbed by a small region in the outer segments of squid photoreceptors fixed in glutaraldehyde, a brief pulse of membrane current flows locally. The passive spreading of this current along the outer segments produces the photochemical component of the "early receptor potential." The source of the current lies electrically in parallel with the cell membranes and perhaps is located within them. Fixation with glutaraldehyde apparently does not reduce the resistance of the cell membrane to less than 5 percent of its value in live cells.


Durum-type wheat with high bread-making quality. A durum-type wheat (2n = 4x = 28) with high bread-making quality was produced by crossing a durum-wheat variety with a common bread-wheat variety (2n = 6x = 42), backcrossing to the bread-wheat variety for three generations, and then selecting for 28-chromosome plants. The high quality is tentatively attributed to a translocation involving one of the D-genome chromosomes.


Macrophage cultures: an extracellular esterase. An enzyme having esterase activity accumulates in the culture media of mouse peritoneal mononuclear leukocytes during differentiation of the cells into macrophages. It has a pH optimum of 6.5 and shows aryl esterase characteristics. The esterase differs from another macrophage hydrolase, acid phosphatase, in its mainly extracellular distribution.


Cabbage aphid: effect of isolation on form and on endocrine activity. Isolated wingless cabbage aphids, Brevicoryne brassicae (L.), produced only wingless young. Aphids isolated from birth all became wingless, whereas over 50 percent of grouped controls developed wings. Isolation caused hyperactivity of the corpus allatum; this hyperactivity may have caused the wingless form.


Lipids and the assembly of chloroplast membrane.


Colorimetry.

Colorimetry.


Serum iron in elderly hospital patients.


Prospective geriatric bed requirements in a mental hospital.


Falling blood pressure in old age.

Falling blood pressure in old age.


Urinary tract infection in old age.

Urinary tract infection in old age.


Conversion of spontaneous atrial fibrillation in dogs, using direct current synchronized shock.


Hypertension and mitral incompetence associated with multiple systemic and pulmonary artery stenoses in a Caucasian child.


Penile urethral fistula as a complication of circumcision.


Falsely positive Pregnosticon tests.

Falsely positive Pregnosticon tests.


A low-mineral ash diaper developed for strontium balance studies in infants.


Effects of azathiprine in a disorder of uric acid metabolism and cerebral function.


Therapeutic orphans.

Therapeutic orphans.


Isoniazid prophylaxis in tuberculin reactors.


Residencies and fellowships in pediatric subspecialties and general academic pediatric training.


Deferoxamine as a chelating agent.

Deferoxamine as a chelating agent.


Phenylketonuria: evaluation of therapy and verification of diagnosis.


Conradi's disease. Chondrodystrophia calcificans congenita, congenital stippled epiphyses.


A familial syndrome of renal, genital, and middle ear anomalies.


Transplacental infection due to ECHO virus type 22.


Congenital hepatic fibrosis presenting as hepatomegaly in early infancy.


Skin manifestations of the battered-child syndrome.


Earlier maturation in man.

Earlier maturation in man. A trend toward earlier menstruation of children is confirmed by the decline in the age at which girls 1st menstruate and increases in children's height and weight.  Reports documenting a change in children's size between 1880 and 1960 are available from several European countries, the US, Canada, Japan, Hong Kong, New Zealand, and Australia.  The data suggest that, beginning in 1900, children aged 5-7 years who lived under average economic conditions increased in height between 1/2-3/4 inch/decade.  The height increase for those 10-14 years of age has been 1-1 1/2 inch/decade.  Children 5 years of age in 1965 were 2 inches taller than their counterparts 50 years earlier, 9 year olds were 3 inches taller, and 11 year olds were almost 4 inches taller.  This trend appears to be levelling off in the US, indicating that the best-off children have approached the maximum rate of maturation.  An even more dramatic trend has been noted for average age at menarche.  Menarche has been experienced progressively earlier, to the extent that puberty occurs 2 1/2-3 1/2 years earlier than it did 100 years ago.  Moreover, there is no indication that the current level represents the earliest possible age.  Nutrition is regarded as the environmental factor most responsible for earlier puberty and large size.  Support for this hypothesis is provided by data from England and Poland showing a stronger trend toward earlier maturation among poor children whose lives have been more dramatically improved by modernization.  A consistent relationship has also been noted between age at menarche and family size.  The larger the number of children, the later the menarche and the less the height and weight at all ages.  The sibling-number effect may be expressed through malnourishment or a greater incidence of chronic diseases.  It is concluded that although the trend toward larger size and earlier maturation has been firmly established, its causes remain to be investigated.


The venous system.

The venous system.


The cigarette war--who is winning?

The cigarette war--who is winning?


Substitution of the stapedial arch by free cartilage grafts.


Middle ear disease in Turner's syndrome.


Middle ear mucosa and chronic ear disease.


Paralysis of the facial nerve: caused by acinic cell carcinoma.


Anatomic variations in the area of the oval window.


Malignant melanoma of the mouth.

Malignant melanoma of the mouth.


Nevoid basal cell carcinoma syndrome.

Nevoid basal cell carcinoma syndrome.


Chronic ulcerative pharyngitis: radiographic studies of progressive dysphagia in five patients.


Laryngeal hyperkeratosis due to primary monilial infection.


Nonpenetrating traumatic perforation of the pharynx.


Renal tubular acidosis due to amphotericin B.


Studies on digitalis. XVII. Effects of ouabain on the hemodynamic response to exercise in patients with mitral stenosis in normal sinus rhythm.


If a child must die.

If a child must die.


Surgery of the heart and great vessels.

Surgery of the heart and great vessels.


Oral hypoglycemic agents and the mechanism of diabetes mellitus.


Prophylactic antibiotics and heart surgery.


Obstruction at the mitral valve.

Obstruction at the mitral valve.


Molecular composition of myelin synthesized subsequent to irradiation.


The response of uracil-2-14C to x-irradiation under nitrogen and oxygen and to treatment with ascorbic acid.


Deposition of triglycerides of increased carbon number in irradiated rat marrow.


Abnormal anaphases in regenerating mouse livers.


Energy loss of alpha particles in tissue.


Multiplicity reactivation of gamma- and x-irradiated Vaccinia virus in L cells.


Recovery from radiation injury in the hamster as evaluated by the split-dose technique.


Modification of hair dysplasia curve by radioprotectors containg sulfur as a function of the x-ray dose.


Leukocytosis-inducing factor in the blood of x-irradiated rats.


The relationship of exposure rate and exposure time to radiation injury in sheep.


Role of estrogen in the cerebral control of puberty in female rats.


Studies on the composition and properties of immunochemical grade human pituitary follicle stimulating hormone (FSH): comparison with luteinizing hormone (LH).


Evidence for the secretion of thyrocalcitonin at normal and subnormal plasma calcium levels.


Responses of fetal rat bone to thyrocalcitonin in tissue culture.


An improved assay of parathyroid hormone.


Effect of prolactin on progestin release and cholesterol storage by rabbit ovarian interstitium.


Reduced accumulation of 3H-norepinephrine in the rat heart following hypophysectomy.


Thyroxine and norepinephrine effects on the metabolic rates of heat-acclimated hamsters.


Effect of tannation on the activity of a gonadotropin extract of human pituitary glands.


Effect of thyroid state on myocardial contractility.


Stimulation of female sex behavior in adrenalectomized rats with estrogen alone.


Influence of local estrogen administration in vaginal glycogen.


Mechanism of the antipyretic action of glucocorticoids.


Estrogenic and antiestrogenic effects of clomiphene, MER-25 and CN-55,945-27 on the rat uterus and vagina.


Effect of stimulation of the vagus nerve on the thyroidal release of 131I-labeled hormones.


Effects of hypercalcemia and hypocalcemia on the thyrocalcitonin content of rat thyroid glands.


The renal clearance of amino acids in a patient with Wilson's disease during penicillamine treatment.


Identification and measurement of cysteine-homocysteine mixed disulfide in plasma.


Characteristics of beta hemolytic streptococci associated with acute glomerulonephritis in Trinidad, West Indies.


The preservation of blood for transfusion. VI. Effect of addition of adenine and inosine on ATP and posttransfusion survival of red cells of stored blood.


Plasma renin activity during development of experimental antiserum glomerular nephritis.


Rapid diagnostic method for cat scratch disease.


Cyclicity in the interrelationships between plasma insulin and glucose during starvation in normal young men.


Results of pulmonary function testing in 5 persons with the Marfan syndrome.


Platelet adherence to fibrin and collagen.


The relationship of adenosine triphosphate concentration to erythrocyte aging.


Presidential address. The doctors' dilemma: academic medicine in transition.


Influence of estradiol and estriol on urinary excretion of hydroxyproline in man.


The effect of iron deficiency on the levels of hemoglobins A2 and E.


Quantitative aspects of the inhibitory effect of the iodide ion on parotid salivary iodide and pertechnetate secretion in man.


Isolation of human PMN leukocytes and granules: observations on early blood diluion and on heparin.


Immune status of the primary host toward its own methylcholanthrene-induced sarcomas.


Mammary gland transplantation and tumorigenesis. I. Concentration and clearance of 7,12-dimethylbenz[a]anthracene in the graft.


Chromosome pulverization in human cells with micronuclei.


Herpes-type virus in cultured leukocytes from chimpanzees.


Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States.


Chromosome conditions of hypodiploid moloney virus-induced mouse leukemia, its transplantability and inductivity.


Tetanus toxoid.

Tetanus toxoid.


Pseudoasbestos bodies and asteroid giant cells in a patient with graphite pneumoconiosis.


Phenylketonuria and diet.

Phenylketonuria and diet.


Digital strangulation by hair wrapping.

Digital strangulation by hair wrapping.


Evidence for passage of cerebrospinal fluid among spinal nerves.


Open renal biopsy.

Open renal biopsy.


Value of a cardiac arrest team in a university hospital: results in a series of 100 patients.


Migration of lymphocytes and thymocytes in the rat. I. The route of migration from blood to spleen and lymph nodes. The cellular deficit in rats thymectomized at birth is primarily one of circulating small lymphocytes. The lymphocyte deficiency is similar to that induced in adult rats by chronic drainage from a thoracic duct fistula. In both cases, the animals show a reduction of small lymphocytes in peripheral blood, thoracic duct lymph, and in circumscribed areas of lymphoid tissue. The lympocyte deficiency in lymphoid tissue can be corrected by an intravenous injection of thoracic duct lymphocytes. The evidence suggests that the deficiency is corrected by small lymphocytes. Small lymphocytes pass from blood to lymphoid tissue along a route which includes the marginal sinus in splenic white pulp and postcapillary venules in the cortex of lymph nodes and Peyer's patches. Neither the ability of small lymphocytes to colonize lymphoid tissue nor their ability to traverse postcapillary venules are thymus-dependent phenomena. However, movement of small lymphocytes across postcapillary venules appears to modify the structure of endothelium. Intravenously injected small thymocytes migrate to lymphoid tissue in smaller numbers than small lymphocytes inoculated by the same route. The few thymocytes which localize in lymphoid tissue follow the same pathway as circulating small lymphocytes.


Suppression of adjuvant disease in the rat by heterologous antilymphocyte globulin. The effect of antilymphocyte globulin (ALG) on adjuvant arthritis, an immunologically induced disease in the rat, was studied. ALG was prepared from the serum of rabbits immunized against rat lymphocytes. Adjuvant arthritis was induced in rats by a single intracutaneous injection of Freund's complete adjuvant; after 9 to 12 days, all control rats developed polyarthritis. Administration of antilymphocyte globulin about the time of adjuvant injection produced marked inhibition of clinical disease. Some suppression was apparent even when ALG was started after the onset of arthritis. Rats receiving ALG remained conspicuously healthy compared to controls. Urinary findings and renal histology showed no evidence of nephritis. The results of serum corticosterone determinations made it unlikely that adrenal stimulation contributed to the actions of ALG. Antilymphocyte preparations lowered peripheral lymphocyte counts and suppressed primary antibody responses to sheep erythrocytes, but had little effect on the skin reaction to PPD, even in rats protected from arthritis. All rats given ALG developed antibodies to rabbit globulin; there was no evidence that ALG inhibited the appearance of antibodies to itself, and prior hyperimmunization of rats with rabbit globulin did not interfere with the biological activity of ALG subsequently injected. Antisera produced separately against lymph node and thymus cells had identical properties with regard to agglutination of lymphocytes and thymus cells. Administered to rats, these preparations were equally potent in lowering lymphocyte counts and suppressing both adjuvant arthritis and the primary antibody response to sheep erythrocytes. It is concluded that ALG, as used in these experiments, is a potent immunosuppressive agent without obvious toxic effects.


Ultrastructural localization of antibody in differentiating plasma cells. Antibody was localized by electron microscopy within differentiating and mature plasma cells of the spleens of hyperimmunized rabbits. Horseradish peroxidase was used as antigen. Intracellular antibody to peroxidase was revealed in glutaraldehyde-fixed tissue by coupling it with its antigen and then revealing the sites of peroxidase activity cytochemically. Antibody first appears in the perinuclear space of hemocytoblasts where it persists through differentiation into immature plasma cells, but it disappears from this site in mature plasma cells. Concomitant with the development of the ergastoplasm, antibody accumulates in many but not all of its cisternae. Antibody is present in the lamellar portion of the Golgi apparatus in all phases of plasmacytic differentiation. Mature plasma cells exhibit two types of antibody distribution, a concentration into large spherical intracisternal granules or an overflowing into all parts of the cytoplasm.


Hemopoietic colony studies. V. Effect of hemopoietic organ stroma on differentiation of pluripotent stem cells. In heavily irradiated mice, bone marrow regeneration of either endogenous or exogenous origin was shown to occur in discrete foci comparable to the more intensively studied spleen colonies. The number of endogenous bone marrow colonies was inversely related to dose of whole body X-irradiation. Endogenous marrow colonies were found after higher doses of irradiation than were endogenous spleen colonies. Most of them were granulocytic in nature. Exogenous bone marrow colonies in lethally irradiated mice injected with bone marrow cells were proportional in number to the dose of cells injected, appeared at a time comparable to spleen colonies like which, at 7 or 8 days, they were of single differentiated cell line, either granuloid or erythroid or megakaryocytic, with a small percentage of "mixed" colonies. Whereas erythroid colonies outnumber granuloid colonies in spleen, either in situ or subcutaneously transplanted (E:G colony ratio of about 3.5), granuloid colonies outnumber erythroid in bone marrow (E:G colony ratio of about 0.7). The characteristic E:G colony ratios of spleen and marrow appear more likely to be the result of a hemopoietic organ stromal influence on pluripotent colony forming units (CFU's) than of selective lodgment of committed (unipotent) granuloid and erythroid CFU's in bone marrow and spleen, respectively, as indicated by the following. Bone marrow stem cells (CFU) which had reseeded the marrow cavity of irradiated primary recipients 18-24 hr earlier, were reharvested and retransplanted intravenously into irradiated secondary hosts. The E:G colony ratio of the colonies formed in the spleen of the secondary hosts was typical of primary spleen colonies (2.8), that of the colonies formed in the marrow cavity was typical of bone marrow colonies (0.6). Pieces of marrow stroma containing reseeded CPU's from the contralateral femur of these same primary recipients were implanted by trocar directly into the spleens of other irradiated secondary recipients. Those CPU's that developed in the intrasplenic-implanted marrow stroma yielded an. E:G colony ratio of 0.1. Those that migrated into the contiguous and remote portions of the spleen gave E:G colony ratios of 2.9 and 2.4, respectively. Irradiated marrow stroma and normal spleen CPU's (a 1 mm cube of spleen) were loaded into the same trocar and implanted directly into the spleens of irradiated mice. The spleen CFU's that migrated into the implanted marrow stroma yielded five granuloid and two mixed colonies. The larger number that developed in the host spleen yielded an E:G colony ratio of 2.9 or higher. Of those 19 mixed colonies that bridged the junction of spleen and implanted marrow stroma in each of the above two experiments, in every case, the erythroid portion of the colony was in the splenic stroma, the granuloid portion was in the marrow stroma.


The experimental induction of glomerulonephritis like that in man by infection with group A streptococci. 106 rabbits received one or more courses of inoculations, spaced 1-4 months apart, with Group A streptococci, usually of strains isolated from patients with acute glomerulonephritis. 8 days to a few weeks after onset of a given infection with streptococci known to have been nephritogenic for man, marked proteinuria, often with hematuria and occasionally with azotemia, was detected in 22 of the animals. 15 of these were sacrificed a few days to a few weeks thereafter, and 10 showed renal changes like those of acute or recurrent acute glomerulonephritis in man. Such changes occurred in three other rabbits whose urine was not examined that died or were sacrificed 1-3 wk after onset of infection with streptococci of a serotype known to include a strain nephritogenic for man. The remaining seven animals in which marked proteinuria had occurred died or were sacrificed many months later, in some cases after additional infections. Two of these had become azotemic and two convulsed and died after giving birth; in these animals, there were renal changes like those that occur in man in chronic latent glomerulonephritis, toxemia of pregnancy super-imposed on chronic latent glomerulonephritis, or chronic active glomerulonephritis. Anatomical changes in the kidneys in the experimentally induced and in naturally occurring glomerulonephritis, from acute to chronic stages, are compared and illustrated. The pathogenesis of poststreptococcal glomerulonephritis is discussed.


Reflux of oxygenated blood into the pulmonary artery in severe mitral regurgitation.


The treatment of cardiogenic shock. IV. The use of phenoxybenzamine and chlorpromazine.


Cardiovascular stress (electrocaridographic changes) produced by driving an automobile.


Coronary care unit: a review of 300 patients monitored since 1963.


Atrial septostomy.

Atrial septostomy.


Spatial QRS curves of the newborn infant. Spatial magnitude, velocity, and orientation (Frank system).


Mechanical injury to the coronary arteries during operative cannulation.


The congenital cardiovascular anomalies underlying "reversed coarctation".


Bronchopulmonary precapillary blood flow during cardiopulmonary bypass.


Analysis of a cardiac cycle of the left side of the heart in cases of left ventricular overloading or damage with the ultrasonic Doppler method.


Pacemaker vectorcardiography.

Pacemaker vectorcardiography.


Pulmonary edema induced by renal extracts originating from rats with experimental hypertension.


Imipramine in the treatment of enuretic schoolchildren. A double-blind study.


Some effects of diphenylhydantoin and propranolol on the cardiovascular system.


Medication during labor correlated with behavior and EEG of the newborn.


Intramural duodenal hematoma in children.


Acute glomerulonephritis associated with normal serum B1C-globulin.


Modification to the technique for small bowel biopsy in children including the use of metoclopramide.


Pediatric emergency room patient. A comparison of patients seen during the day and at night.


Picture of the month. Tuberous sclerosis.


Chronic granulocytic leukemia. Early blast crisis simulating acute leukemia.


Acrodynia treated with D-penicillamine.

Acrodynia treated with D-penicillamine.


Prolonged obstructive jaundice. Report of a case in a neonate with meconium ileus and jejunal atresia.


Congenital bronchomalacia.

Congenital bronchomalacia.


Congenital heart disease and chondroectodermal dysplasia. Report of two cases, one in a Negro.


Complete breast absence in siblings.

Complete breast absence in siblings.


A case of?6p- chromosomal aberration.

A case of?6p- chromosomal aberration.


Physiologic skin pH patterns in infants of low birth weight. The onset of surface acidification.


A new age.

A new age.


Host enzyme induction of bacterial infection.


Paralytic mumps infection in two sisters.


Clinical evaluation of cephaloridine.

Clinical evaluation of cephaloridine.


Phonocardiographic discrepancies in the assessment of mitral stenosis.


Erythrocyte rubidium uptake in normal and cancer patients.


Chronic lymphocytic leukemia, Hodgkin's disease, and the nephrotic syndrome.


Renal infarction. Elevation of serum and urinary lactic dehydrogenase (LDH).


Pheochromocytoma with renal artery compression in an identical twin.


Pulmonary artery stenosis murmurs. A new diagnostic sign of pulmonary embolism.


Advanced techniques for fluorescein angiography.


Acquired cone dysfunction and other photopic system diseases.


Corneal damage in cryoextraction of cataracts.


Practical characteristics of ophthalmic magnets.


Lighting and health hazards.

Lighting and health hazards.


Central and peripheral corneal thickness. A clinical study.


Solid vs. cystic basal cell epitheliomas of the eyelids. Correlation of clinical and pathological diagnoses.


Initial treatment of eye injuries. First Corps Area of Viet Nam, 1966.


Clinical study of senile retinoschisis.

Clinical study of senile retinoschisis.


Corneal complications from cryoextraction of cataracts.


Histopathology of juvenile retinoschisis.


Congenital alacrima.

Congenital alacrima.


Lacrimal canalicular repair. A simplified technique for intubation.


An iris retractor for cataract surgery.

An iris retractor for cataract surgery.


Virus-induced cataracts. Incidence and development in rats after intracerebral inoculation of St. Louis encephalitis virus.


Retinal damage by visible light. An electron microscopic study.


An evaluation of cataract cryoextraction.


Ovarian response to human chorionic gonadotrophin and egg transport in the pregnant and post-parturient rabbit.


Endocrine and histological studies on oligospermic men treated with human pituitary and chorionic gonadotrophin.


Oxytocin test to demonstrate the initiation and end of lactation in rats.


A biochemical oestrogen assay.

A biochemical oestrogen assay.


The specific acitivity of plasma cortisol in sheep after intravenous infusion of [1,2-3H2]cortisol, and its relation to the distribution of cortisol.


A comparison of the conversion in vitro of pregnenolone sulphate and pregnenolone to steroid hormones by tissue from a clear cell adenoma of the adrenal gland.


The effect of anterior pituitary hormones on carbohydrate metabolism in vitro in the prepubertal rat ovary.


Enzymes of lactose biosynthesis in normal and hormonally stimulated rabbit mammary glands.


Family planning.

Family planning.


Gas chromatographic analysis of the unconjugated, neutral non-polar steroids of human placenta.


Management of a colostomy.

Management of a colostomy.


Sleep. I. 'Perchance to dream'.

Sleep. I. 'Perchance to dream'.


The Hospital Centre; what is it?

The Hospital Centre; what is it?


Home again at 90.

Home again at 90.


The nurse teacher in sex education.

The nurse teacher in sex education.


Glandular fever.

Glandular fever.


Child care and mental health.

Child care and mental health.


The story of Eva; nursing care study.

The story of Eva; nursing care study.


Figleaves or farthingales?

Figleaves or farthingales?


Are uniforms necessary?

Are uniforms necessary?


Student nurse allocation. A planned programme. 2.


Familial dysautonomia. A cineradiographic study of the swallowing mechanism.


Hematoma as a cause of radiographic deformity of stomach.


Small bone changes secondary to systemic lupus erythematosus.


Radiographic changes in rheumatoid arthritis in the digits.


Epidermolysis bullosa dystrophica in children. Radiologic manifestations.


Heel-pad thickness in obese persons.

Heel-pad thickness in obese persons.


New rapid roll-film changer.

New rapid roll-film changer.


Practical problems in processing control.


Penetration through the blood-brain barriers of cats after intracarotid injections of 125-I sodium diatrizoate, methylglucamine diatrizoate, or methylglucamine diatrizoate plus parabens and the retention of 131-I methylglucamine diatrizoate in the blood of rats.


Indium-113m diethylenetriaminepentaacetic acid (DTPA): a new radiopharmaceutical for study of the kidneys.


Plane spread-functions in radioisotope scanning.


Iliac lymph node aspiration biopsy through paravascular approach; preliminary report.


Bronchography with a directable double catheter.


Pursuit of shadows.

Pursuit of shadows.


The spatial frequency spectrum: a means for studying the quality of radiographic imaging systems.


Three-dimensional computer read-out of radioiosotope scan data.


Dural arteriovenous malformation in the posterior fossa.


The trigeminal nerve shadow in the basal cisternogram.


Bilateral rete mirabile intracranial (vascular) anastomosis in man. A case report.


Mycotic infection of the paranasal sinuses. Radiographic manifestations.


Roentgen appearance of fat necrosis in the breast.


Limited value of lymphanigography in Hodgkin's disease.


Idiopathic osteosclerosis. A report of 6 related cases.


A simple method for lower extremity phlebography--pseudo-obstruction of the popliteal vein.


Epispadias.

Epispadias.


Correlation of chest roentgenograms and hemodynamic findings following surgical repair of ventricular septal defects.


Mediastinal lymph node visualization in the absence of intrathoracic disease.


Effect of timed occlusions at various levels of mesenteric arteries and veins: correlative study of arteriographic and histologic patterns of rat gut.


Correspondence: obstacles to population control.


Science policy confrontation.

Science policy confrontation.


Gardner's resignation: the crunch between expectations and resources.


International cancer research: new horizons for epidemiology.


Ten-armed fossil cephalopod from the Pennsylvanian of Illinois. Jeletzkya douglassae Johnson and Richardson is described as the oldest known representative of an extant squid group. The species is known from a single specimen from the Middle Pennsylvanian of Illinois. This very unusual fossil consists of the complete tentacular crown and a fragile shell. The arms bear hooks in double rows.


Solid-state energy-dispersion spectrometer for electron-microprobe x-ray analysis. Improved lithium-drifted silicon solid-state detectors allow detection and energy dispersion of x-rays of about 3 to 30 kiloelectron volts in the electron-microprobe x-ray analyzer. Energy resolution is sufficient to separate peaks of characteristic x-rays of elements adjacent in the periodic system at atomic number 20 and higher. The detected x-ray spectrum emitted from an unknown sample can be recorded with a multichannel analyzer in approximately 60 seconds.


Lipoperoxidation of lung lipids in rats exposed to nitrogen dioxide. Absorption spectra characteristic of diene conjugation and typical for peroxidized polyenoic fatty acids can be induced in rat lung lipids after the rats have been exposed to a scant amount of nitrogen dioxide (1 part per million) for 4 hours. The peroxidative changes do not occur immediately but appear to reach a maximum between 24 and 48 hours after exposure. The prooxidant effect of this atmospheric pollutant in rat lung lipids may be partially prevented by prior treatment of the animal with large doses of alpha-tocopherol.


Circadian oscillation controlling hatching: its ontogeny during embryogenesis of a moth. Populations of eggs of the moth Pectinophora gossypiella develop a circadian rhythm of hatching activity under certain circumstances. This rhythm derives from circadian oscillations in each egg, which can be initiated or made synchronous by steps or pulses of either light or temperature, but only if these signals are administered after the midpoint of embryogenesis. Correlations between the development of the oscillation, appearance of a pigment, sensitivity to photoperiodic induction, and a possible effect of light on growth rate are discussed.


Vascular smooth muscle: quantitation of cell thickness in the wall of arterioles in the living animal in situ. The wall of microarterial vessels, in the living animal in situ, was examined at magnification up to x 6500 on the television screen. The optical resolution af the cell components of the wall was sufficiently clear to permit image formation and splitting for permanent recording and quantitation. Thickness of single smooth muscle cells at rest was estimated to be 2.08 microns (S.D. +/- 0.24 micron) and 2.78 microns (S.D. +/- 0.59 micron) by two different approaches. Changes in cell thickness during activity were also recorded and quantitated.


Morphogenetic interaction of presumptive neural and mesodermal cells mixed in different ratios. Cells of the presumptive forebrain region and axial mesoderm of Triturus neurulae were disaggregated and combined in different ratios. The differentiation of the central nervous systen in these explants was dependent on the relative amount of mesodermal cells present: an increase of mesodermal cells resulted in a corresponding increase in the frequency with which caudal structures of the central nervous system developed and a gradual loss of the forebrain formations.


Phytostat for continuous culture and automatic sampling of plant-cell suspensions. An apparatus for growing plant cells in suspension culture is described; it may be used for continuous or batch culture, and is equipped with a valve for automatic collection of samples. Aeration is by continuous bubbling of air into the culture through fritted glass. Normal culture-duplication times are from 30 to 35 hours.


Anhydrous uric acid: nature and occurrence of a new form of urinary calculi. A second form of anhydrous uric acid has been found in urinary calculi; it is probably derived as an artifact from uric acid dihydrate during storage. It has been prepared in the laboratory by desiccation of uric acid dihydrate. Mixtures of these two substances sometimes give x-ray powder patterns that resemble that of xanthine on weak photographs, but are distinguishable by their infrared spectra.


Renal adenyl cyclase: anatomically separate sites for parathyroid hormone and vasopressin. Adenyl cyclase from plasma membrane fractions of rat renal cortex or medulla was assayed by measuring conversion of adenosine triphosphate labeled at the alpha-phosphate with (32)P to cyclic 3',5'-adenosine monophosphate labeled with 32P. Parathyroid hormone activated the enzyme primarily in cortex; vasopressin acted primarily in medulla. These experiments support the conclusion that cyclic adenosine monophosphate mediates the action of parathyroid hormone on the kidney and show that parathyroid hormone and vasopressin stimulate adenyl cyclase at anatomically separable areas within the kidney.


The FDA looks at pain-relieving drugs.

The FDA looks at pain-relieving drugs.


Vaso-atonic headache associated with chronic maxillary sinusitis.


Vasoactive substances and fibrosing syndromes.


Changed patterns of "sinus headache".

Changed patterns of "sinus headache".


Headaches and the eye.

Headaches and the eye.


Complicated migraine and its treatment.

Complicated migraine and its treatment.


Hypokalaemia in the elderly.

Hypokalaemia in the elderly.


Teaching geriatrics.

Teaching geriatrics.


Clinical uses of systemic deoxyribonuclease.


The joint assessment and early treatment unit in psycho-geriatric care.


Medical aspects of accommodation for the elderly.


Further portrait of a psycho-geriatric hostel.


A socio-architectural view of life in three homes for old people.


The outcome of surgery for ulcerative colitis.


Problems in the pathology of malignant disease.


Appendiceal calculi resembling gallstones.


Superior mesenteric vein thrombosis complicating pancreatoduodenectomy: successful treatment by thrombectomy.


Non-epidermoid cancer of the larynx.

Non-epidermoid cancer of the larynx.


Two views of carcinoma of the tongue.

Two views of carcinoma of the tongue.


Blood case monitoring in the operating room and recovery room.


Neuroblastoma: natural history and results of treating 133 cases.


Combined surgical and radiation injury. The effect of timing of wounding and whole body gamma irradiation on 30 day mortality and rate of wound contracture in the rodent.


Experience with radical neck dissection in the management of 426 patients with malignant tumors of the head and neck.


Chest wall compliance.

Chest wall compliance.


Intestinal absorption and nitrogen balance following portacaval shunt.


Indirect method of extraction of foreign body from the esophagus.


The role of splenectomy in Felty's syndrome.


The repair of large or difficult hernias with mattressed onlay grafts of fascia lata: a 21-year experience.


Patency after thrombectomy for iliofemoral thrombosis.


Malignant villous tumor in a colon bypass.


The rat with a portacaval anastomosis.

The rat with a portacaval anastomosis.


Synovial fine structure and permeability after intra-articular nitrogen mustard.


Butter effects on White Carneau pigeons. Observations on serum cholesterol, body weight, and aortic and coronary atherosclerosis.


Myofibrillar degeneration. A response of the myocardial cell to injury.


Anomalous termination of a hepatic vein in the left atrium.


A resident's viewpoint of pathology residency.


Medical impairment and assessment of disability.


Electromyographic studies of articulation in aphasia.


A method of cystometry to record bladder activity in neurogenic dysfunction.


Heating of joint structures by ultrasound.


Energy cost of playing golf.

Energy cost of playing golf.


Measurement of the duration of effect of long-acting diazepam in spastic disorders.


Hypnosis for alleviation of pain in treatment of burns: case report.


Prosthetic spinal support following hemipelvectomy in a paraplegic patient.


Method of kinematic study of normal upper extremity movements.


Regulation of pulmonary capillary blood volume by pulmonary arterial and left atrial pressures.


Study of erythrocyte aggregation by blood viscometry at low shear rates using a balance method.


Enhancement of coronary vasodilating action of ATP and adenosine by lidoflazine.


Blood flow through terminal arterial vessels after denervation of the bat wing.


Dissociation of circulating renin and erythropoietin in rats.


Medical counseling of parents of the retarded. The importance of a right start.


Adolescents' gynecologic problems. Medical aspects.


Management of pneumomediastinum and subcutaneous emphysema.


Polymyositis in children.

Polymyositis in children.


Eugenics and genetic equilibrium.

Eugenics and genetic equilibrium.


Premature pubarche.

Premature pubarche.


Bleeding mechanisms with special attention to coagulation disorders.


Some fundamentals of emotional growth in children.


Poor school achievement: a psychiatric study and classification. II. Case management and follow up.


Headaches and abdominal pains in the adolescent.


Coma from accidental phenothiazine ingestion. An unusual metabolic effect.


Tuberculous meningitis developing during the course of chemotherapy for pulmonary tuberculosis.


Educating the doctor about drug costs.

Educating the doctor about drug costs.


"Hot line" for teenagers.

"Hot line" for teenagers.


Pneumomediastinum and subcutaneous emphysema in measles.


The effects of radiation therapy on laryngeal function.


Incus homografts: viability and rate of bone repair by tetracycline labels and fluorescent microscopy in the cat.


Mondini type of genetically determined deafness.


Deafness in myositis ossificans progressiva.


Otosclerosis in the lateral semi-circular canal.


Some unusual experiences with oestrin therapy.


Hypophysectomy. A report on 50 operations for metastasizing breast cancer.


Using Xenon-133 and a scintillation camera to evaluate pulmonary function.


Studies on quantitation of the 51Cr-erythrocyte spleen-to-liver ratio.


100-level smoothed scintiscans processed and produced by a digital computer.


Enlarging gamma-camera scans.

Enlarging gamma-camera scans.


Data blending with 99mTc in evaluating thyroid anatomy by scintillation scanning.


Formaldehyde-treated 131-I-albumin: a possible brain-tumor scanning agent.


Ge(Li) semiconductor detectors as high-resolution gamma-ray spectrometers in nuclear medicine.


A review of cancer of the corpus uteri in New South Wales.


Induction of labour.  II. Intravenous oxytocin infusion.


Rupture of the uterus. A clinical study of 181 cases.


Induction of labour. 3. Results with amniotomy and oxytocin "titration".


Clinical and laboratory tests in cases of postmaturity.


A case of vaginitis emphysematosa.

A case of vaginitis emphysematosa.


The managment and complications of asymptomatic bacteriuria in pregnancy. Report of a study on 8,275 patients.


Chromosome studies on women who have had two or more unsuccessful pregnancies.


Ovulatory menstrual cycles with abnormal urinary steroid patterns.


Studies of pilot performance: I. Theoretical considerations.


Hormonal treatment of recurrent endometrial carcinoma. Report of a case.


Studies of pilot performance: II. Evaluation of performance during low altitude flight in helicopters.


On-line personnel testing for naval aviation.


Blood volume studies during and after immobilization in human subjects as measured by sodium radiochromate (chromium 51) technique.


Experimental determination of the mechanical properties of bone.


Development and evaluation of a simplified formula food for aerospace feeding systems.


Thousand aviator study: nonvestibular contributions to postural equilibrium functions.


Transient changes in arterial oxygen tension during positive (+Gz) acceleration in the dog.


A continuing survey of parasitism in a Midwestern college community.


Human acceleration experience at the Aerospace Medical Research Department, U.S. Naval Air Development Center, Johnsville, 1 January 1961-30 December 1965.


Microdetermination of calcium in biological material by automatic fluorometric titration.


An integrated approach to the aeromedical investigation of civil aircraft accidents.


Infrared spectra of microgram amounts of amino acid phenylthiohydantoins eluted from thin layers of silica gel.


Two new myths: one-unit transfusions and LW factor.


Quantitative measurement of cystine in urine. Modification of the Sullivan test with sodium beta-naphtho-quinone-4-sulfonate.


Turbidimetric evaluation of platelet aggregation in the Chandler tube.


Preservation of sensitized red blood cells for serologic diagnosis of mycoplasma pneumoniae infections.


Horse agglutinins in infectious mononucleosis. II. The spot test.


Use of a heating block incubator for leukocyte culture.


Laboratory suggestion. A safety device for attaching and removing microtome knife back.


An unsuspected ultrastructural fault in human elliptocytes.


Small-bowel ulceration--iatrogenic or multifactorial orgin?


Horse agglutinins in infectious mononucleosis.


Frozen section experience in 3000 cases. Accuracy, limitations, and value in residency training.


Florid breast fibroadenomas in patients taking hormonal oral contraceptives.


A histochemical demonstration of aldehyde in elastin.


Histochemistry of hyaluronidase. Tissue localization of hyaluronidase in the testis by a new substrate film technic.


Melanogenic epithelium in the prostate gland.


Enlarged intra-abdominal pacinian corpuscles simulating tumor implants.


Amebic meningoencephalitis due to free-living amebas of the Hartmannella (Acanthamoeba)-Naegleria group.


Meningitis due to Edwardsiella tarda. First report of meningitis caused by E. tarda.


Constrictive pericarditis following radiation therapy.


Evaluation of a latex particle agglutination test for coccidioidomycosis.


Acute renal failure in multiple myeloma.


A case of Weber-Christian disease with roentgenographically demonstrable mammary calcifications.


Early diagnosis of chronic pulmonary vascular obstruction. Value of pulmonary function tests.


Chronic obstructive bronchopulmonary disease. II. Oxygen transport in two clinical types.


Chronic ulcerative (nongranulomatous) jejunitis.


Changes in rheumatoid factor activity during the course of sarcoidosis.


Editorial, the medical journal--forum for the translator.


Factors influencing pulmonary gas exchange in patients with acute edematous cor pulmonale due to chronic lung disease.


Chronic urticaria. A clinical study of fifty patients.


Effect of acute and chronic ethanol treatment on the absorption of iron in rats.


Morphologic alterations associated with neomycin induced malabsorption.


Diabetes mellitus and idiopathic hemochromatosis.


Control of diarrhea by cholestyramine administration.


Giant duplication of the jejunum. Case report.


Radiation injuries to the lower gastrointestinal tract.


The surgical binocular microscope in neurological surgery.


Surgical treatment of Hirschsprung's disease: persistent obstruction associated with a retained transitional segment.


The clinical value of esophageal intraluminal manometry.


Ameloblastoma of the mandible: a clinical study of 25 patients.


The role of the heart in shock: exsanguination studies.


Full thickness resection of the cheek for carcinomas of the anterior buccal mucosa and commissure with immediate one-stage reconstruction.


Surgical aspects of pulmonary embolism.

Surgical aspects of pulmonary embolism.


The growth of germfree beagles.

The growth of germfree beagles.


Intramural hematoma of the colon following blunt trauma to the abdomen.


Hemoperitoneum as a complication of acute cholecystitis: a report of two cases.


Cardiac anomalies and splenic agenesis.

Cardiac anomalies and splenic agenesis.


Comparison of three physiological adhesives as hemostatic agents in abdominal viscera.


Autoimmune hemolytic anemia and neoplasia of the reticuloendothelium. With a hypothesis concerning etiologic relationships.


Alternate-day amphotericin B therapy in the treatment of rhinocerebral phycomycosis (mucormycosis).


Atheromatous emboli with progressive renal failure. Renal arteriography as the probable inciting factor.


Pancreatic insufficiency as the presenting feature of hyperparathyroidism.


Megaloblastic anemia possibly induced by triamterene in patients with alcoholic cirrhosis. Two case reports.


Stramonium poisoning in "teeny-boppers".


Coombs'-test positivity induced by drugs. Mechanisms of immunologic reactions and red cell destruction.


The direct Coombs' test: its clinical significance. Study in a large university hospital.


Laboratory tests in the diagnosis of hyperparathyroidism in hypercalcemic patients.


Clinical diagnosis and clinical judgment.


Treatment of hepatic coma in cirrhosis by plasmapheresis and plasma infusion (plasma exchange).


The challenge of the Regional Medical Program.


Medical care in the urban center.

Medical care in the urban center.


Self-assessment of medical knowledge.

Self-assessment of medical knowledge.


Variants of glucose 6-phosphate dehydrogenase.


Immunology and cancer.

Immunology and cancer.


Letters and comments. "Deleted Y chromosome".


Letters and comments. Autonomous thyroid nodules.


Cryoprecipitate concentrates of factor 8 for surgery in hemophiliacs.


Carbohydrate metabolism in uremia.

Carbohydrate metabolism in uremia.


Arthritis and skin lesions resembling erythema nodosum in pancreatic disease.


Hereditary pancreatitis. A kindred without gross aminoaciduria.


Vietnam ophthalmology.

Vietnam ophthalmology.


Leber's congenital amaurosis with an Ehlers-Danlos-like syndrome. Study of an American family.


A "new" iron line of the superficial cornea. Occurrence in patients with filtering blebs.


Retinitis pigmentosa and Coats' disease.


Allergic contact dermatitis to proparacaine.


Anaphylactoid reaction to intravenously administered fluorescein.


Lipid granuloma of the orbit.

Lipid granuloma of the orbit.


Treatment of persistent central serous retinopathy.


An electromyographic investigation of ophthalmoplegia in thyrotoxicosis.


Systemic absorption of topical steroids.


External ophthalmoplegia secondary to systemic amyloidosis.


Photocoagulation of choroidal melanoma. Early and late histopathologic consequences.


Alveolar soft-part sarcoma of the orbit.


Microtubules in the lens.

Microtubules in the lens.


Benign ocular hypertension.

Benign ocular hypertension.


Osteopathia striata, osteopetrosis, and impaired hearing. A case report.


Perceptive hearing loss and arterial hypertension.


The anterior commissure technique of partial laryngectomy.


Evoked response (EEG) audiometry in nonorganic hearing loss.


Acinic cell carcinoma of the sublingual gland.


Tracheal reconstruction with silastic reinforced dacron.


Prolonged intubation vs tracheotomy in children.


Ciliostatic effect of orthocresol and metacresol.


Radiopaque filled Foley balloon in posterior epistaxis.


Carbon dioxide narcosis. An unusual complication of postnasal packing.


A method for control of posterior nasal hemorrhage.


Radiographic anatomy of the paranasal sinuses. I. Waters' view.


Radiographic anatomy of the paranasal sinuses. II. Lateral view.


Pathologic quiz case 2.

Pathologic quiz case 2.


Pathologic quiz case 1.

Pathologic quiz case 1.


A method for the experimental induction of bronchogenic carcinoma.


Sparing action of uridine on the activity of arabinosylcytosine with normal and leukemic mice.


Spontaneous interstitial and Sertoli cell tumors of a testis in a C3H mouse.


A serum alkaline phosphatase isoenzyme of human neoplastic cell origin.


The role of thymus epithelial reticular cells in viral leukemogenesis.


Inhibition by actinomycin D of DNA synthesis and skin tumorigenesis induced by 7,12-dimethylbenz(a)anthracene.


Effects of a series of purine analogs on Friend leukemia virus infections in mice.


Serum protein bound hexoses in patients with breast cancer.


Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds upon the synthesis of DNA by cell-free systems.


Reversible inhibition of DNA synthesis in hamster embryo cells in culture: action of 1,2-benzanthracene and 7,12-dimethylbenz(a)anthracene.


On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia.


Segregation of the nucleolus produced by anthramycin.


Effect of mithramycin on a mouse glioma.


Antigenic competition between polypeptidyl determinants in normal and tolerant rabbits. Competition between two polypeptidyl determinants was studied in normal rabbits and rabbits made tolerant to the competing antigen. The capacity of poly-DL-phenylalanyl protein conjugate to inhibit the formation of antibodies specific to the poly-DL-alanyl determinant was dependent on the nature of the protein carrier of the singly substituted antigens. Competition occurred only when the peptidyl determinants were attached to identical or similar (RSA and HSA) carriers. Thus, the immune response toward the poly-DL-alanyl determinant was impaired by injecting the pairs p-DL-PheRSA and p-DL-AlaHSA, or p-DL-PheRNase and p-DL-AlaRNase. Suppression of the formation of antibodies with poly-DL-alanyl specificity was not observed, however, upon administration of p-DL-PheRSA together with p-DL-AlaRNase or of p-DL-PheRNase with p-DL-AlaHSA. Tolerance to p-DL-PheRSA was induced by injecting this material into newborn rabbits. The tolerant animals retained their capacity to produce anti-poly-DL-alanyl antibodies upon injection of p-DL-AlaRSA or p-DL-AlaHSA. However, when these poly-DL-alanyl proteins were administered together with p-DL-PheRSA, antibodies against the poly-DL-alanyl determinant were not formed even though no antibodies with poly-DL-phenylalanyl specificity were produced. These results indicate that in competition experiments the preference in the immune response against a given determinant is dependent not only on the nature of the competing determinants, but it is also governed to a large extent by the over-all properties of the antigenic molecules. This suggests that at the stage at which the competition occurs the competing molecules had not undergone considerable degradation. On the basis of experiments with tolerant animals, it is suggested that in normal animals antibody formation to the competing antigen is not the cause of its inhibitory action on the response against the other antigen. The competition experiments described suggest that an antibody-forming cell is multipotent.


Delayed hypersensitivity. I. Effect of in vitro exposure of cells to antigen upon leukocytic transfer of delayed hypersensitivity. Exposure to picryl guinea pig albumin with 3-6 picryl groups per mole failed to affect the ability of peritoneal exudate or peripheral blood leukocytes from sensitized donors to transfer delayed sensitivity to normal recipients. In contrast, conjugates containing 40-48 picryl groups per mole altered the ability of exposed leukocytes to transfer delayed sensitivity. Evidence is presented that highly conjugated guinea pig albumin is self-aggregating. Lightly conjugated albumin, previously heat-aggregated, also was effective in "desensitization." The properties of antigen size, cell association of antigen after exposure, and desensitization appear to be associated.


Regulation of cellular antibody synthesis. Cellular 7S production and longevity of 7S antigen-sensitive cells in the absence of antibody feedback. Transfer of spleen cells from mice immunized against sheep red blood cells (SRBC) into irradiated (600 R) nonimmune, syngeneic mice in the presence of antigen resulted in excessive cellular 7S production 7 days later. The number of 7S plaque-forming cells usually exceeded 10(6) per spleen and the mean proportion varied between 1 and 70%. In occasional animals all spleen cells were producing antibodies to SRBC. Serum antibody synthesis was also excessively increased, the titers in agglutination after 2-ME treatment and in hemolysis varying between 2(15) and 2(25). The generation time of the 7S PFC was found to be 9.6 hr in the secondary hosts. It seemed possible that the excessive production of 7S PFC and antibodies in the irradiated nonimmune recipients was caused by the absence of feedback inhibition of the immune response by antibody, a mechanism which would normally function to restrict antibody synthesis. This conclusion was strengthened by the demonstration that transfer of antigen-stimulated immune cells into actively or passively immunized irradiated recipients resulted in a marked suppression of cellular 7S synthesis. Serial transfers of antigen-stimulated immune cell populations in irradiated hosts resulted in an equally high number of 7S PFC during the first four transfer generations. However, after the fifth to seventh transfer generation the number of 7S PFC rapidly declined and disappeared within one to three passages. Serum antibodies and 7S PFC declined in parallel during the last transfer generations. Further passages of antigen-stimulated spleen cells lacking 7S PFC did not lead to reappearance of PFC. Thus, antigen-sensitive cells have a limited lifespan and/or multiplication capacity. From the hypothesis that the 7S PFC developed by division from antigen-sensitive precursors it was calculated that 38-40 divisions occurred, Thus, one antigen-sensitive precursor has the potential to give rise to 10(12) 7S PFC.


Antigens in immunity. XIV. Electron microscopic radioautographic studies of antigen capture in the lymph node medulla. Details of antigen trapping and processing in the rat lymph node have been investigated by the technique of high resolution radioautography. A series of 24 adult rats was injected with 20 microg of (125)I-labeled Salmonella adelaide flagella, given as either a primary or a secondary stimulus into one hind foot-pad. At intervals ranging from 3 min to 3 wk, rats were killed and the popliteal nodes were processed for electron microscopic radioautography using Kodak NTE emulsion. The present paper deals with events in the lymph node medulla, and an accompanying report describes the radically different behavior of antigen in the cortical follicles. In the medulla, lightly labeled granulocytes were transiently encountered, but by far the greatest bulk of antigen was in macrophages. Antigen entered these cells in two ways: by direct penetration of the plasma membrane; and by pinocytosis. In either case, the antigen rapidly became surrounded by tiny vesicles which may have represented Golgi-derived "protolysosomes." Vacuolar fusion ensued and a series of progressively larger and more complex antigen-containing "phagolysosomes" was formed. Substantial amounts of antigen could be detected in such bodies for at least 3 wk. The antigen injection, as expected, caused extensive plasma-cytopoiesis. No evidence of label in plasma cells was obtained. No special anatomic relationship between plasma cells and antigen depot sites was discovered. These results are briefly discussed in relation to current theories of immune induction.


The X-Y-Z scheme of immunocyte maturation. IV. The exhaustion of memory cells. A set of conditions has been described under which primed rabbit lymph nodes produce a secondary antibody response upon in vivo stimulation with a large dose of antigen, but are subsequently "exhausted;" that is, lymph node cultures prepared at intervals following the booster injection cannot be re-stimulated to display tertiary responses. Rabbits given 100-fold less antigen in the booster inoculum were able to give a tertiary response upon in vitro challenge. The system used permits neither induction nor continuation of a primary response to BSA in vitro. Since it could be demonstrated that no memory cells were generated by the booster injection within the intervals between in vivo injection and culture, the tertiary response in nonexhausted nodes must have been due to residual memory cells which remained untriggered by the in vivo booster injection. The unresponsive state was not caused by antibody feedback. These results are interpreted to mean that a population of memory cells can be exhausted by a supraoptimal dose of antigen, rendering the node temporarily incapable of further response. This implies that long-lived memory is not due to asymmetric division of memory cells. The source and fate of memory cells is discussed with regard to this evidence.


Need for a new national body.

Need for a new national body.


Nursing a patient with a gastric fistula.


Studies on the pathogenesis of fever. XVI. Purification and further chemical characterization of granulocytic pyrogen. Small quantities of highly purified granulocytic pyrogen have been separated from contaminating proteins by disc electrophoresis in polyacrylamide gel. The biologically active material thus isolated was shown to be electrophoretically homogeneous at pH 9 and pH 3.8. Earlier work on the chemical properties of the pyrogen molecule has been extended to include: (a) estimation of its molecular weight by gel filtration; (b) demonstration of free sulfhydryl groups essential for its biological activity; and (c) evidence that it is not inactivated by exhaustive extraction with ethanolether or n-heptane.


Psychiatric domiciliary visiting.

Psychiatric domiciliary visiting.


Alcoholic and drug addiction units.

Alcoholic and drug addiction units.


Acute myocardial infarction; a case study.


Obstetric diasters. 2. Pre-eclamptic toxaemia. A new method of assessing placental function.


When the accident is all yours.

When the accident is all yours.


Irreducible right inguinal hernia.

Irreducible right inguinal hernia.