Clinicopathological studies on the coronary circulation with postmortem coronary angiography.


Examination of the "voltage clamp technique" with the electrochemical model of excitation.


Effect of corticosteroids on blood pressure, serum electrolytes, plasma volume and extracellular fluid volume in rats.


Experimental studies on morphogenesis of arteriosclerosis, with special reference to relation between hemodynamic change and developments of cellulofibrous. Intimal thickening and atherosclerosis.


The measurement of linguistic change. A study in the field of human development.


Rate sensitivity of the mechanism of pressure induced change of vascular resistance.


A study on "acquired athrombia".

A study on "acquired athrombia".


Difference in coagulation activity of blood samples taken from coronary sinus and femoral artery in normals and in subjects with coronary atherosclerosis.


The in vitro and in vivo effect of xanthinol niacinate on platelet aggregation, adhesion and blood coagulation.


A baffling epidemic: atherosclerosis, with reference to blood lipid levels in two new Mexico ethnic populations.


The effect of oestriol succinate on bleeding time.


Rheumatic fever and rheumatic valvular disease in Turkey.


Disseminated bosinophilic collagen disease.


Recurrent agranulocytosis associated with dysproteinemia and diffuse plasma cell infiltration.


Observations on the development in vitro of the microfilaria of Wuchereria bancrofti after prolonged hypothermia.


Morphologic variation in the larva of Aedes aegypti, Trinidad strain.


Follow up studies on the hemorrhagic fever in Calcutta during 1964 and 1965.


Mitosis of cultured human amnion cells after infection by variola and vaccinia viruses.


Compound 377 in the treatment of leprosy.


Household infections of 8 cholera cases in Calcutta during 1966.


Treatment of ascites.

Treatment of ascites.


Tuberculin sensitivity in protein-calorie deficiency: Preliminary observations.


Serological response in cholera-like diarrheas.


Preliminary observations on the activity of diaphorase in hemoglobin E-thalassaemia disease.


Enzyme studies in carbohydrate metabolism in some clinical conditions. VII. Determination of phosphoglucomutase in RBC.


Taraxerol from Careya arborea.

Taraxerol from Careya arborea.


Transaminase in experimental trichinosis.


Drugs vs cancer.

Drugs vs cancer.


Dose-response relationships for the clinical and pharmaceutical evaluation of glaucoma drugs.


Comparative evaluation of the use of diathermy and cryocautery in the treatment of retinal detachment.


An evaluation of iridectomy with scleral cautery.


Definitions, distinctions, and dichotomies.


Statistical randomization in the behavioral sciences.


Growth incentives in the "have-not" nations.


Hydrocarbons in digestive tract and liver of a basking shark. The hydrocarbons of zooplankton pass through the digestive tract of the basking shark without fractionation or structural modification. They are resorbed in the spiral valve and deposited in the liver. In contrast to unsaturated fatty acids, the olefinic hydrocarbons are not decreased in concentration. The hydrocarbon assemblage in the digestive tract and in the liver is indicative of the food sources and feeding grounds of the shark. Squalene, abundant in shark liver, occurs only in traces in zooplankton; phytane, if present at all, constitutes less than 0.005 percent of the hydrocarbons of zooplankton and of shark liver.


Molecular biology: British groups push enzyme-structure studies.


Gastrin antibodies: induction, demonstration, and specificity. Antibodies to the antral hormone gastrin have been induced in the rabbit and detected by passive hemagglutination. Specificity of the antibody, as determined by three methods, is directed to gastrins I and II, gastrin pentapeptide, and gastrin tetrapeptide, as well as to the stage-1 gastrin used for immunization.


"Hemoglobin alpha2beta2-121ys" chemical identification in an egyptian family. Stuidy of the amino acid composition and amino-terminal residue in the abnormal peptide of an electrophoretically slow hemoglobin revealed that the globin's structure was alpha(2)beta(2)(121 Lys) (Obeta). This hemoglobin had been provisionally classified as Hb E or as a new heemoglobin. The clinical significance of this abnormality is not yet defined.


Malic dehydrogenase isozymes: distribution in developing nucleate and anucleate halves of sea urchin eggs. Nucleate and anucleate halves of sea urchin eggs have seven and five forms of L-malic dehydrogenase, respectively. Fertilization results in reduction of the number of enzyme forms in both halves. The normal complement of seven isozymes in unfertilized eggs appears to be a synthesis of five soluble and four particulate forms. Reduction in the number of isozymes after fertilization takes place principally in solutble forms and appears to be under cytoplasmic control.


Perceived number and evoked cortical potentials. Evoked cortical potentials and the numsber of flashes perceived were compared when subjects were presented with short trains of flashes under conditions where each presented flash could not be counted individually, but the train of flashes appeared to be flickering (1 to 14 flashes at 33.3 flashes per second). The rate at which each successive perceived flash was added appeared to correspond with the rate at which the successive components of the evoked response pattern were added. The temporal nature of this pattern was similar for both single flashes and trains of flashes. The results suggest that the onset of stimulation triggers a process whlich has a marked effect on both the cortical and perceptual response to subsequent stimulation.


Nomenclature of glucose 6-phosphate dehydrogenase in man.


Polymorphic and monomorphic serum esterase heterogeneity in catostomid fish populations.


The genetic control of alkaline phosphatase activity in the duodenum of the mouse.


Isozyme variability in species of the genus Drosophila. II. A multiple allelic isozyme system in Drosophila busckii: a stable polymorphic system.


The way of insight.

The way of insight.


The use and misuse of gonadal steroid hormones in gynecology.


More--on speaking to patients.

More--on speaking to patients.


Psychotherapy in the practice of medicine.


The mental health of Seventh-day Adventists.


Moral issues of CB warfare.

Moral issues of CB warfare.


Moral issued of CB warfare.

Moral issued of CB warfare.


Congressional witnesses.

Congressional witnesses.


Weightlessness can be confusing.

Weightlessness can be confusing.


A poverty of spirit in underdeveloped nations.


NSF defends individual rights.

NSF defends individual rights.


A partisan attack on research.

A partisan attack on research.


The court-martial of Captain Levy: medical ethics v. military law.


Atmospheric ions and germination of uredospores of Puccinia striiformis. Atmospheric ions, identified by mobility characteristics, were associated with germination of lyophilized uredospores of Puccinia striiformis West. at Bozeman Montana. Ions of intermediate size were highest in concentration, and percentage germination of spores was lowest during periods conducive to air pollution. In duplicate experiments at an isolated site near Barrow. Alaska, essentially all atmospheric ions were small ions and the fungus spores were consistently germinated near maximum.


Ethylene formation from ethyl moiety of ethionine. In plants, ethylene is formed in the presence of light and flavin mononucleotide from ethionine and S-ethylcysteine. The ethylene is formed from the ethyl moiety of ethionine.


Photosynthetic system II: racial differentiation in Typha latifolia. The rate of reduction of 2,6-dichlorophenol-indophenol by illuminated chloroplasts isolated from ecological races of Typha latifolia was negatively correlated with length of growing season at the site of origin. Efficiency of the photochemical apparatus for this reaction was twice as high in a high-altitude population from Wyoming as in a maritime population from California.


Spectrophotometric cell sorter.

Spectrophotometric cell sorter. A new device can physically separate cells of predetermined optical properties, from large populations of cells in suspension.


Yeast transfer RNA: a small-angle x-ray study. The intensity of x-ray scattering and the radius of gyration were measured for a mixture of yeast transfer RNA's in tenth molar potassium chloride. The experimentally observed radius of gyration eliminates single-stranded, hairpin, singly folded hairpin, triple-stranded, and linked double-hairpin models of tRNA but allows certain folded cloverleaf models. The measured intensities at larger angles, beyond the radius of gyration region, lend some support to the Holley's cloverleaf model, in which three arms are folded up tightly together and the fourth arm is extended in the opposite direction.


Saturation in milk and meat fats.

Saturation in milk and meat fats. Meat and milk products from ruminants (cows, goats, sheep, and beef animals) contribute 35 to 40 percent of the fat in the average American diet. Such fat is highly saturated, containing less than about 4 percent polyunsaturated fatty acids. The unsaturated plant lipids (fats) ordinarily consumed by the ruminant are hydrogenated (saturated) in the rumen. Transport and incorporation of this hydrogenated fat into meat and milk follows. Rumen hydrogenation does not take place until the fat is broken down to free fatty acids, thus establishing the fact that lipolysis is an essential feature of the process. Circumvention of this lipolysis may lead to more-unsaturated meat and milk fat.


Lepidocrocite, an apatite mineral, and magnetic in teeth of chitons (Polyplacophora). X-ray diffraction patterns show that the mature denticles of three extant chiton species are composed of the mineral lepidocrocite and an apatite mineral, probably francolite, in addition to magnetite. Each of the three minerals forms a discrete microarchitectural unit of the chiton denticles. This is the first indication that lepidocrocite is precipitated by marine organisms and an apatite mineral by chitons.


Polonium-210: removal from smoke by resin filters. Use of a mixed ion-exchange resin as a filter for cigarettes markedly reduces both the total amount of polonium-210 in mainstream smoke and the picocuries per milligram of smoke. This procedure effectively minimizes exposure of the lungs of smokers to alpha irradiation.


Calcium-selective electrode with liquid ion exchanger. A simple calcium-selective electrode has been developed which is capable of measuring calcium ion activity in the presence of many common interfering ions. The electrode utilizes a liquid ion exchanger membrane containing the calcium salt of a disubstituted phosphoric acid.


Acropetal movement of auxin: dependence on temperature. The amounts of radioactive indole-3-acetic acid that moved, both basipetally and acropetally, through short sections of bean epicotyl were measured at 15 degrees and 25 degrees C in the presence and absence of 2,3,5-triiodobenzoic acid. Low temperature and this second compound each inhibited acropetal efflux of indole 3-acetic acid more than they did the influx. Results are interpreted as supporting a metabolically dependent component of the acropetal movement of auxin in bean epicotyls.


Light-enhanced potassium absorption by corn leaf tissue. The rate of absorption of potassium by slices of corn leaf in the light was about twice the rate in the dark. When the light was turned on or off, changes in the rate of absorption took place some minutes after the change in illumination. Experiments with the antimetabolites, 2,4-dinitrophenol and cyanide, indicated that the source of energy for active accumulation of potassium by green tissue in the light was different from that in the dark. In the light, energy was closely linked to photosynthetic reactions; in the dark, it was linked to respiratory processes.


Messenger RNA patterns in rat liver nuclei before and after treat-ment with growth hormone. Like cortisol, growth hormone enhances RNA synthesis in rat liver nuclei. However, DNA-RNA hybridization experiments show that the application of growth hormone does not stimulate the formation of new species of messenger RNA. The latter phenomenon was observed after treatment with cortisol.


Oxygen tension changes evoked in the brain by visual stimulation. Localized changes in oxygen tension were recorded with platinum cathodes placed in the lateral geniculate nucleus in both anesthetized and awake cats. The amplitude of the responses increased with increasing stimulus intensity, but decreased with increasing flash rate. Both increases and decreases in cathode current were produced by steady illumination. The characteristics of the responses suggest that the responses reflect localized variations in blood flow, produced in turn by changes evoked in the tonic neural activity of the lateral geniculate nucleus.


Phycomyces sporangiophores: fungal stretch receptors. The application of mechanical force to the sporangiophore of Phycomyces elicits a transient growth response. The immediate stimulus may be the deformation of the sporangiophore under the applied force. Compression of the cell causes an interval of faster growth, and extension causes an interval of slower growth.


Stimulus preferences and imprinting.

Stimulus preferences and imprinting. Pekin ducklings were tested with respect to their preference for approaching one of two simultaneously presented, rotating, silent duck decoys, painted in a variety of colors or patterns. Some of the ducklings had not been given any previous visual experience other than that gained in a 20-minute introduction to the empty apparatus; others had previously been given the opportunity to follow one particular decoy for 20 minutes. The decoys could be grouped into three categories: those in the first category were treated as equivalent, that is, so long as the duckling had followed one of these models it would approach either. The decoys of the second category were ones to which "imprinting" occurred, that is, the ducklings showed a decided preference for the model they had originally followed, whichever it was. The third category included models, one of which was always preferred, though the controls showed no such preference. The effects of the imprinting procedure vary with the stimuli presented.


Information retrieval.

Information retrieval.


Moral issues of CB warfare.

Moral issues of CB warfare.


Aphids.

Aphids.


Inhibition of mitosis by surfactants.

Inhibition of mitosis by surfactants.


Cytoplasmic cytology of primary and secondary Brown-Pearce tumors.


Inner chromosomal structures in the stomatic metaphase of the rat kangaroo (Potorous tridactylis). A light microscopic observation.


The collagen protein formation in tissue cultures of human diploid strains.


Histochemical studies on nucleolus and nucleolar extrusions in dipteran oogenesis.


Nuclear changes following treatment with actinomycin D.


Studies on plasma insulin in women. 3. Effect of retro-progesterone and tolbutamide administration during the normal menstrual cycle.


Clinical observations on 8 cases of myotonia dystrophica.


Tissue culture of human gingiva. I. Comparative study of normal and diseased human gingiva in tissue culture.


Studies on the diagnosis and surgical treatment of intracranial hemorrhage due to head injuries.


Studies on plasma insulin in women. 1. Effect of glucose administration during the normal menstrual cycle, normal pregnancy and the normal postpartum period.


Actual conditions of the severely mentally retarded children in Tokushima Prefecture.


Studies on plasma insulin in women. 2. Effect of glucose administration in the anovulatory cycle, toxemia of late pregnancy and glycosuria of pregnancy.


Noteworthy recent tick records from Egypt. 2. Hosts, distribution, and ecology of Rhipicephalus simus koch.


Further note on Anopheles stephensi in Egypt, U.A.R.


Detection of cholera carriers at El Tor quarantine camp during the pilgrimage seasons 1966 and 1967.


Mumps virus as an important causative agent to aseptic meningoencephalitis.


Epidemiological features of accidents. I. A comparative study of adjusted mortality in 27 countries including U.A.R., and methods of analysis.


Thombelastographical evaluation of the coagulative system of the blood and fibrinolysis in craniocerebral injuries.


Percutaneous transhepatic cholangiography.


A comparison of the haemagglutination-inhibition and neutralisation test in the essay of rinderpest antibodies in cattle.


Further brucellosis surveys in Tanzania.


Military research: a decline in the interest of scientists?


Genetic control of alcohol dehydrogenase isozymes in maize.


UDP-glucose: alpha-D-galactose-1-phosphate uridylytransferase activity in cultured human fibroblasts.


Isozyme variability in species of the genus Drosophila. I. A multiple allelic isozyme system in Drosophila busckii: inheritance and general considerations.


A tetrazolium method for distinguishing between cultured human fibroblasts having eiter normal or deficient levels of glucose-6-phosphate dehydrogenase.


Human transferrins C and D-Chi: an amino acid difference.


A method for estimating the number of invariant amino acid coding positions in a gene using cytochrome c as a model case.


Some aspects of regional lung function in chronic bronchitis.


Vascular tone, vascular distensibility, and alveolar deadspace in lungs.


The series conductors of the lung in controlled breathing.


Alveolar-arterial gradients for oxygen and carbon dioxide in pulmonary embolization.


Airway obstruction due to hypoxemia in patients with chronic lung disease.


Pulmonary embolism.

Pulmonary embolism.


The effects of pulmonary embolism on pulmonary capillary bloodflow.


Pulmonary lymphatics in relation to pulmonary clearance, interstitial fluid and the pathogenesis of emphysema.


Two groups of subjects with obstructive lung disease, defined by pulmonary vascular reactivity.


Bronchial hypersensitivity to mecholyl and histamine in asthma subjects.


Vasoactive substances in the lung.

Vasoactive substances in the lung.


Adrenergic innervation of bronchial muscle.


Airways resistance, airflow and inhomogeneity of distribution of ventilation as independent abnormalities of bronchial asthma.


The response of central and peripheral airways to vagal stimulation in dogs.


Viscoelasticity of mucus: its role in ciliary transport of pulmonary secretions.


An investigation of the movement of Newtonian liquids initiated and sustained by the oscillation of mechanical cilia.


A postmortem study of viscoelastic properties of lung in emphysema (correlation with quantitative morphometry).


Mucus flow in the mammalian trachea.

Mucus flow in the mammalian trachea.


The relative importance of bronchiolitis and extent of centrilobular emphysema in pulmonary ventilatory interference.


Experimental emphysema: effect of chronic nitrogen dioxide exposure and of papain on normal and pneumoconiotic lungs.


Internal surface area of normal and emphysematous lungs.


Sequence of exposure to environmental agents as a determinant of pulmonary injury.


Clearance from alveoli to the ciliary escalator: implications for pulmonary diseases.


A vortex method for bloodgas extraction and injection into the gas chromatograph.


Cough in health and disease.

Cough in health and disease.


Ventilation studies with synthetic fluids.


Lung scanning in the assessment of obstructive lung disease.


The resistance of small airways in normal and diseased human lungs.


The normal expiratory spirogram--technique.


Microradiography of intrapulmonary bronchial veins of the dog.


Prognosis in chronic obstructive lung disease.


Pathophysiology of the alveolar macrophage system.


Current research in chronic obstructive lung disease. A postscript.


Acute exacerbations and the fall of FEV 0.75 in chronic obstructive airways disease.


The distribution of bronchial resistance in obstructive pulmonary diseaxe and in dogs with artificially induced tracheal collapse.


Respiratory effects of polycythemia: case report.


Phases of adolescence: with suggestions for a correlation of psychic and hormonal organizations. II. Prepuberty diffusion and reintegration.


Some group observations on reactions to separation from home in first-year college students.


Some infantile sources of childhood disturbance.


The child's role in therapy. A comparison of the child's sick role in treatment as seen by four disciplines.


The psychotherapeutic workability of the poor.


Individual differences at birth. Implications for mother-infant relationship and later development.


Therapeutic use of psychological reports.


Dilemmas of the juvenile court.

Dilemmas of the juvenile court.


Educational data open questions.

Educational data open questions.


Industry and environment.

Industry and environment.


Energy needs versus environmental pollution: a reconciliation? In this article I have presented, for discussion, a proposed system for energy generation by which the principal sources of environmental pollution by power plants could be eliminated. For stationary power plants the concept appears feasible technically and, according to my " horseback estimates," perhaps economically as well, depending upon the economic value of the by-products of sulfur, CO(2), water, and possibly nitrogen, and upon the price we are willing to pay for a clean environment .Thus, a more thorough engineering and economic analysis to explore these and other factors in greater depth seems warranted. In the case of turbine-driven vehicles, the technical and economic feasibility of widespread distribution and handling of the fuel constitutes a serious question, but one which deserves equally serious consideration before the possibility is discounted. The reports of the cited study panels notwithstanding, the technology required for the proposed system exists today, with one exception. This exception (which is not essential for trial of the system but will be required for its complete fruition) is the development of a nuclear reactor for the prime purpose of delivering process heat for the steam reforming of natural gas and, ultimately, for gas production from coal in a continuous process, such as those discussed by Pieroni et al. (16). Today's intermittent processes of coking and gas production are both archaic and themselves large sources of atmospheric pollution, and a development program aimed at advancing the technology of the coal industry in this regard would seem long overdue. The report of the PSAC Environmental Pollution Panel recommended "demonstration of the feasibility and economy of new developments for abating or controlling pollution through their use at Federal installations" and suggested the coalburning TVA power plants as a likely place for such demonstration. This suggestion is doubly appropriate since the TVA is in a region of subnormal " atmospheric ventilation" (8). By design these plants are adjacent to the AEC's Oak Ridge National Laboratory, and such a location would seem ideal for an experiment on the wedding of nuclear and fossil sources of energy. In comments on a preliminary draft of this article, proponents of "conventional " nuclear power pointed out that such power is hard to beat on the basis of cost, and that dissipation of heat to the air by way of cooling towers can also be accomplished in conventional plants (17). These observations are individually correct but not compatible: the low power costs cited are for very large plants [of the order of 1000 mega-watts lectrical) and larger], and the costs of cooling towers and associated equipment needed to dissipate such large amounts of heat [of the order of 2000 megawatts (thermal)] to air from a closed cycle would offset the power cost advantage of the large plant. In regard to the proposed use of nuclear process heat, Weinberg (20) has expressed doubt that much advantage can be derived from this approach because the temperatures involved are too high for low-cost reactors, and heat transfer from surfaces could involve materials problems. In the case of gas production, this is indeed an anticipated problem-not a technologically insuperable one, but a problem of reducing the cost of the materials required (16). Indeed, Weinberg himself has mentioned this possible use of nuclear heat in a recent publication discussing the steam reforming of coal to liquid fuel(21). Also, an improved process for synthesizing methane from lignitec has recently been reported (22). Since the earlier studies date back a decade, a new look at the problems and costs involved relative to the benefits to be derived (not the least of which could be new vigor for the coal industry) would seem to be in order. In the case of steam reforming of natural gas, the temperature level (about 1500 degrees F) is such that the technology is available today, and a process-heat-reactor design study could be initiated without awaiting further developments.


Federal paper-work explosion: new form bothers universities.


Carbon dioxide--oxygen separation: facilitated transport of carbon dioxide across a liquid film. An immobilized film of an aqueous bicarbonate-carbonate solution was developed which was 4100 times more permeable to carbon dioxide than to oxygen. The carbon dioxide transport was reaction-rate limited, and thus it could be increased by addition to the film of catalysts for the hydrolysis of carbon dioxide.


Modified cilia in sensory organs of juvenile stages of a parasitic nematode. Electron microscopical studies revealed the presence of dendritic nerve processes in sensory organs of the third- and fourth-stage juveniles of Haemonchus contortus, which contained structures resembling modified cilia. With few exceptions, the outer circle of fibers consisted of ten doublets, and in place of typical cilia-like central fibers were small microtubules or vesicles varying in number from zero to five.


Planktonic Foraminifera: field experiment on production rate. In a study of the rate of production of four species of planktonic Foraminifera in the region of the California Current it was found that their life spans are of the order of 1 month. Reproduction seems to take place mainly in the upper hundred meters. Results are in contrast to previous evidence presented in favor of yearly life cycles and maturing at great depth in other species of planktonic Foraminifera.


Mosquitoes: female monogamy induced by male accessory gland substance. Male accessory glands were implanted in virgin females of Aedes aegypti. When exposed to males, females copulated readily but were not inseminated; they remained sterile for life. Extract from one male could sterilize more than 64 females. The active principle may be a protein or peptide. Intraspecific transplant prevented insemination in 12 species, including Aedes, Anopheles, and Culex; interspecific transplant gave partial protection.


Life cycle and variation of Prototheca wickerhamii. Prototheca wickerhamii is a yeastlike organism that resembles the green alga Chlorella. Nuclear division in coordination with cytoplasmic cleavage gives rise to uninucleate cytoplasmic segments, each of which acquires a delicate cell wall and develops into an autospore. The autospores in this species are spherical; but in a variant that presumably arose as a result of spontaneous mutation, the cytoplasmic cleavage is irregular, and the resultant autospores are ovoid to bacillary. When these variant autospores grow, they swell and round up before the nuclear division begins, producing spherical cells like those seen in wild-type cultures. In view of the fact that species concept in the genus is based on size and shape of cells, the variation limits in these morphological characteristics have significant bearing on species classification.


Temperature effect on protein synthesis in a heat-synchronized protozoan treated with actinomycin D. Protein synthesis was studied in the ciliated protozoan Tetrahymena pyriformis GL after actinomycin D was added to the culture medium. When the temperature rose above that optimum for growth, there were significant reductions in protein synthesis. Lipid biosynthesis under the same conditions was slightly stimulated, an indication that the eflect was not due to an underlying reduction in energy sources. The phenomenon appears to be unique to the protein synthesizing system. Correlation with previous data suggests that it is due to nontranslational destruction of template RNA.


Intrauterine devices: effects on ultrastructure of human endometrium. The human endometrium, studied with the electron microscope, undergoes asynchronous and premature cyclic development in response to inin uterine contraceptive devices. Typical nucleolar channel systems and other cellular characteristics of the normal secretory phase appear before ovulation, and decidualization occurs several days prematurely. Disturbance of the synchrony of ovular and endometrial development may be a mechanism of contraceptive action of these devices.


Temperature compensation in short-duration time-measurement by an intertidal amphipod. The duration of the swimming response of an intertidal amphipod to increases in hydrostatic pressure apparently serves to measure the timing of wave uprush on the beach. Experiments have demonstrated that this response to a standard pressure-increase stimulus varies in duration only slightly with temperature over the range from 10 degrees to 28 degrees C, with estimated Q(10) values of 1.3 to 1.5. Relative insensitivity to temperature, such as here described, seems to be an essential component of biological time-measuring systems (including endogenous circadian, tidal, and lunar rhythms) that are ecologically keyed to the timing of temperature-independent environmental factors.


Nonhormonal basis of maternal behavior in the rat. Rats were tested for induction of maternal behavior by exposing them to young pups continously for 10 to 15 days. Nonpregnant intact, ovariecto-mized. and hypophysectomized females were studied, as well as intact and castrated males. Nearly all the animals exhibited the four main items of maternal behavior and there were only minor differences in the latencies for the onset of maternal behavior among the various groups. It is concluded that all rats have a basic level of maternal responsiveness which is independent of hormonal stimulation.


Inheritance.

Inheritance.


Estuaries: will Congress save them from encroachments?


Evolutionary significance of metabolic control systems. The beta-ketoadipate pathway provides a case history in bacteria.


Secret research: tightrope act on Capitol Hill.


Coordination polymers of osmium: the nature of osmium black. The design of cytochemical reagents that yield osmiophilic products from which an osmium black may be derived on exposure to osmium tetroxide has resulted in new methods described previously for the ultrastructural demonstration of enzyme activity and functional groups of macromolecules with the electron microscope. Attempts to determine the nature of the osmium black end products have been frustrated by their insolubility. The preparation of watersoluble analogs and their characterization as polymers suggest that the insoluble osmium blacks are coordination polymers. This is consonant with the unusually favorable properties of osmium black in electron microscopy. Although polymers of osmium have frequently been postulated as the end products of reaction of osmium tetroxide with tissue conistituents or with other organic compounds, this is the first example of their characterization.


Dimethyl sulfoxide protects tightly coupled mitochondria from freezing damage. Dimethyl sulfoxide prevented loss of respiratory control and decrease in efficiency of oxidative phosphorylation when plant mitochondria were stored in liquid nitrogen. Respiration was severely inhibited and was not stimulated by adenosine diphosphate when mitochondria were frozen in liquid nitrogen without dimethyl sulfoxide. Thus, isolated mitochondria provide a model system for the study of the effects of freezing on biological membranes and of the prevention, by dimethyl sulfoxide, of freezing damage.


Ring D chromosome: a second case associated with anomalous haptoglobin inheritance. A second child with a ring D chromosome and anomalous inheritance of haptoglobin has been identified. Autoradiographic studies of peripheral lymphocytes from this child and of those from the previously described patient indicate that the ring in each is derived from chromosome No. 13. These findings are evidence that the locus for the haptoglobin alpha-chain is situated on one end of chromosome No. 13.


Cholinesterase in plasma: first reported absence in the Bantu; half-life determination. A Bantu schoolgirl is the first non-Caucasoid found homozygous for the "silent" cholinesterase gene. Investigation of her family revealed two heterozygotes. The propositus possesses no antibody to normal cholinesterase. Transfused cholinesterase had in her a half-life of approximately 10 days.


Tetrodotoxin: effects on brain metabolism in vitro. A 3-micromolar concentration of tetrodotoxin completely inhibits the stimulation of respiration of rat brain cortex that takes place upon application of electrical impulses. It also inhibits increase in the rate of the respiration that occurs when calcium ions are omitted from the incubation medium. No effect of tetrodotoxin on brain respiration takes place when stimulation is brought about by the addition of 100 millimolar potassium chloride. Tetrodotoxin prevents the fall in the rate of oxidation of cerebral acetate that occurs during electrical stimulation but does not affect the increased rate of the oxidation that occurs in the presence of an increased concentration of potassium chloride. The data indicate that oxidation of cerebral acetate is diminished by influx of sodium ions, which is prevented by tetrodotoxin, and is increased by influx of potassium ions, which is unaffected by tetrodotoxin.


Thermoregulation in the desert iguana Dipsosaurus dorsalis. The body temperature of desert iguanas implanted with miniature temperature-sensitive radio transmitters was continuously monitored in their natural habitat. Extensive thermoregulatory behavior occurred in retreat burrows prior to morning emergence. Such behavior permits the igluana to emerge from below ground at its preferred body temperature rather than suboptimal temperature at which activity in the burrow is initiated.


Fire ant venom: synthesis of a reported component of solenamine. 2-Methyl-3-hexadecylpyrrolidine was synthesized. It has hemolytic activity as has solenamine, but it apparently does not have the insecticidal activity of the fire ant venom. As judged by gas chromatography, the structure is not a component of solenamine.


Interferon binding: the first step in establishment of antiviral activity. Chick cells incubated at 1 degrees C with interferon fail to develop antiviral activity, but this activity appears subsequent to a 7-hour incubation at 37 degrees C after removal of interferon by repeated washings. Treatment with actinomycin D blocks the development of the latter activity. Cells incubated with interferon at 1 degrees C for up to 1 hour and then washed and incubated for 2 hours at 37 degrees C develop a degree of antiviral activity proportional to the concentration of interferon at initial incubation; at any concentration, the antiviral activity increased with the duration of initial incubation at 1 degrees C, but a maximal response was reached at 10 or 20 minutes. Treatment with trypsin after incubation with interferon at 1 degrees C inhibited development of antiviral activity. Interferon is rapidly bound to a superficial cell site, and this binding is necessary for development of antiviral activity in chick cells.


Endrin resistance in the pine mouse.

Endrin resistance in the pine mouse. Wild pine mice with a history of treatment with endrin exhibited a 12-fold greater tolerance to the pesticide than did mice having no history of endrin treatment. A genetic basis for the resistance would be expected, in view of the fact that the resistant mice had been exposed to endrin for 11 years. However, sublethal dosages conferred a degree of resistance on both mouse populations; this indicates the possibility of an inducible resistance.


Tetrodotoxin: action on graded responses.


Brain catecholamines: relation to defense reaction evoked by acute brainstem transection in cat. The concentration of noradrenaline, but not serotonin, in the brainstem of cats is reduced 3 hours after the production of a defense reaction by supracollicular decerebration, even when movements and changes in blood pressure are abolished by transection of the spinal cord. After midcollicular decerebration, which does not elicit a defense reaction, noradrenaline concentrations do not change. The decrease in its concentration accompanying the defense reaction produtced by brain lesions probably reflects activity, in this behavior, of neturons containinig noradrenaline.


The early diagnosis of acoustic neuroma.


Office management of corneal lesions.

Office management of corneal lesions.


Current research in otolaryngology.

Current research in otolaryngology.


Diagnostic uses of ultrasound.

Diagnostic uses of ultrasound.


The president's message.

The president's message.


Use of teacher aides in special education: a review and possible applications.


Academic achievement of brain injured and hyperactive children in isolation.


The prognostic value of Carter-Buck tests in measuring articulation skills of selected kindergarten children.


Help for the teacher of disturbed children in the public school: the use of consultation for problem solving and personal growth.


The effects of segregated and partially integrated school programs on self concept and academic achievement of educable mental retardates.


Human locomotion on the moon surface.

Human locomotion on the moon surface.


Toxicological analysis of weckamines (amphetamine, pervitin, preludin and ritalin) in pharmacuetical compounds and urine of persons suspected from doping.


A review of forty one cases of parathion (E605) poisoning by man.


Enhancement of thyroid activity by prolactin in the estivating male newt, Triturus cristatus carnifex (Laur.).


Caveat computator.

Caveat computator.


Collection, evaluation, and transmission of hospital laboratory data.


The assay of pharmaceutical proteinases.


68Ga-chromic phosphate-albumin aggregates for lung scanning.


Turnover rate of zinc in rats after intravenous injection of 65Zn-beta-glycerophosphate.


Rehabilitation.

Rehabilitation.


Syllabus for an industrial health course. Clinical programme, clinics and case demonstrations.


Massive resection of small intestine.

Massive resection of small intestine.


A case of severe multiple injuries and shock.


Tumor of the right humerus.

Tumor of the right humerus.


Hydated cyst of liver.

Hydated cyst of liver.


Skin tumour of thigh.

Skin tumour of thigh.


The duties of an industrial medical officer.


Anterior and posterior sub-epicardial infarction.


Tuberculosis of the wrist joint treated by excision.


Hand injuries due to injection of cement under pressure.


Ergonomics and the industrial medical officer.


How clinical probability judgment may be used to validate diagnostic signs.


Adjective check list correlates of positive and negative sentence completion responses.


A factor analytic comparison of TAT, self-description and reputation assessment techniques.


Imitation and participation in normal and disturbed young boys in interaction with their parents.


Patterns of parent perceptions among neuropsychiatric patients and normal controls.


Pupillary response and sexual interest reexamined.


An eye-movement indicator of type and level of anxiety: some clinical observations.


Experimental studies of cognitive and motor sets: an aspect of psychological deficit in schizophrenia.


Sex-role identification and institutional dependency among veterans undergoing social rehabilitation.


The relationship between facilitation-inhibition and repression-sensitization.


Relationships between dominance needs and decision-making ability.


Relationship between digit span and distractibility ratings in emotionally disturbed children.


Response patterns of Hansen's disease patients on the perceptual reaction test.


Clinical indicators of brain damage in mentally retarded children.


Discrepancies between self-images with and without awareness and their relationship to adjustment.


An experimental measure of personal adjustment from a self concept analysis.


A comparison between free and forced responding to checklists: assessment of the social desirability of stereotypes.


Varying amounts of alcohol and personality inventory performance.


Correlation between IQ and factor B of the sixteen personality factor test with psychiatric patients.


Large scale assessment of state mental patients.


Publishing behavior of graduates from one "clinical clinical" psychology program.


The predicted differential effects of the level of counselor functioning upon the level of functioning of outpatients.


A longitudinal analysis of the effect of experience on the therapeutic approach.


Social alienation as a factor in the acceptance of outpatient psychiatric treatment by the alcoholic.


Educational therapy and withdrawal from smoking.


Work capacity and sport performance in high altitude.


The heart rate-VO2 relationship in different types of dynamic exercise.


Respiratory and circulatory factors affecting the maximal aerobic power in hypoxia.


Study of the real tissue concentration of radioactive tracers, used for the external detection of cerebral tumors.


Adenocarcinoma of the lacrimal gland with metastases to the liver, bones and skin.


Subacute glomerulonephritis in an 8-month-old-infant.


Teratoma originating from the floor of the third ventricle.


An autopsy case of Peutz-Jeghers syndrome.


Hypoglycemia associated with extrapancreatic mesenchymal tumors.


Various analogues to anthranilic acid and their anti-cancer effects.


Traumatic thrombosis of the internal carotid artery due to non-penetrating injury treated surgically with success. Report of a case.


Visceral larvae migrans. Eosinophilic granuloma of the stomach.


A case of calcified cyst of the spleen.

A case of calcified cyst of the spleen.


Evaluation of operative procedure for epidural sagittal hematoma.


Influences of stimulating the mesencephalic reticular formation on spinal interneurons of the cat.


A spontaneous delivery at 36 weeks' gestation after ileocystoplasty.


The Budd-Chiari syndrome. Report of a case.


Studies on post-exercise diuresis. V. Effects of adrenaline and asphyxia upon urinary excretion of endogenous creatinine and sodium thiosulfate injected intravenously.


Automatic analysis of temporal brain tumors using Petersen's analyser and photic stimulation.


On the dosing of liquids according to the drop method.


A modified method for the quantitative paper-chromatographic estimation of l-ascorbic acid.


Effect of proteolytic enzymes on the absorption of tetracycline.


Ultrasonic selective hypophysectomy in advanced prostate or breast cancer and in pituitary diseases. (Cushing, acromegaly, diabetic retinopathy, etc.).


"Regiseal, an industrial hazard".

"Regiseal, an industrial hazard".


Carcinoma of the liver.

Carcinoma of the liver.


Tuberculosis of the spine with paraplegia.


Chondroma of a finger.

Chondroma of a finger.


The medical contribution to the safety of rescue brigadesmen on the mines.


Impaled leg.

Impaled leg.


Pre-employment urinalysis.

Pre-employment urinalysis.


Tuberculous osteitis of a finger.

Tuberculous osteitis of a finger.


Cardiomyopathy in the Bantu.

Cardiomyopathy in the Bantu.


Purpura of the extremities of unknown origin.


Brachial plexus lesion.

Brachial plexus lesion.


Stab into the heart.

Stab into the heart.


The normal hearing of Bantu and Bushmen, a basic study.


Bone cyst of the ulna.

Bone cyst of the ulna.


Fractures humerus with extensive bone loss.


Pharmacotherapeutic census of a psychiatric hospital. II. A comparison with the data obtained one year ago.


Psychological aspects of the relationship between doping and nutrition.


The action of chlorpromazine and imipramine on diuresis in rats.


The effect of oral contraceptives on the mental state of women.


The action of chlorpromazine and amitriptyline on the effects of phenoharmane.


The influence of 2-dimethylaminethanol (DMAE) on the mental and physical efficiency in man.


The effect of methylphenidate on visual imaginative capacity.


Relations between structure and central depressant activity in the series of perathiepin analogs.


Comparative study on the pharmacological properties of the neuroleptics octoclothepine and chlorpromazine.


Electrophysiological studies of the effects of octoclothepine in rabbits.


The effect of perathiepin and octoclothepin on cerebral ischaemia in rats during ontogeny.


A comparative study on the hyperglycemic effects of chlorpromazine and octoclothepine.


A preliminary report on some clinical and biochemical actions of Ro 4-6861, a new antidepressant.


Therapeutic and prophylactic action of lithium against recurrent manic-depressive psychosis.


The dependence of the effect of some psychotropic drugs on the activation of the central nervous system.


Psychotropic activity and reactivity of inbred and out-bred strains of mice.


Investigations on the influence of drugs on sleep cycles in rats--a new method in neuro- and psychopharmacology.


The influence of tryptophane and 5-HTP pretreatment on experimental psychosis induced by LSD.


Spontaneous impulse activity of reticular neurons in curarized, unanesthetized and anaesthetized rats.


An attempt to influence the consequences of paradoxical sleep deprivation by drugs.


Pentobarbital sodium ad- ministration in rats with different levels of nonspecific excitability.


Pharmacological properties of 1-(4'-nitrophenyl)-2-isopropylamino-ethanol (INPEA), a new beta-adrenergic receptor antagonist. V. Effects of the optical isomers D(minus) and L(plus) INPEA on heart rate, oxygen consumption and body temperature and on the cardiac and metabolic effects of adrenaline and noradrenaline in urethane-anesthetized rats.


The development of collateral circulation in the pig and dog heart.


Predictive significance of risk factors in exertional angina pectoris.


Data regarding the morphology of electroshocks experimentally applied to the heart.


Dimensions of change in mental hospital patients.


The visual pigments of freshwater fishes.


A nomogram for retinene-2-based visual pigments.


Intracellular recording of rapid light-evoked responses from pigment epithelium cells of the frog eye.


Melanin and the rapid light-evoked responses from pigment epithelium cells of the frog eye.


The integration of visual stimuli in the rock lobster.


The electroretinogram of the iguana and Tokay gecko.


Periodic activity in the visual system of the cat.


An electrical model of the vertebrate photoreceptor cell.


The angular threshold of discrimination for striated patterns of different orientation in the rabbit.


Color induction using asynchronous flashes.


Nonadditivity and inhibition among chromatic luminances at threshold.


Visual task effect in spectral eye sensitivity.


Visual slant in the circle.

Visual slant in the circle.


Spectroscopic properties of porphyropsins.


A behavioural study on photopic and scotopic vision in the hooded rat.


Spectral sensitivity of the white rat by a training method.


A model for after-effects of seen movement.


Human occipital and retinal potentials evoked by subjectively faded visual stimuli.


Modification of the human visual evoked potential by monochromatic backgrounds.


Electroencephalographic indications of brightness enhancement.


Saturation scales for red.

Saturation scales for red.


Receptive fields of single units in the visual system: a new method for mapping their characteristics and extents.


The congenital isolated mitral stenosis.


The antrum cardiacum in infancy, its site and shape in normal individuals and in hiatus hernia.


A study of the relationship between the thyroid and larval growth in Rana temporaria and Xenopus laevis.


The development of neuro-muscular correlations, in vertebrates.


Nuclear transplantation in Bufo arenarum eggs.


Action of exogenous FSH and internal P32 irradiation on the ovary of the Indian catfish, Heteropneustes fossilis Bloch.


Comparative studies on the chemotherapy of experimental trichinosis in mice.


The race complex of Oncomelania formosana in Taiwan, China.


Differentiation of the myelon and the life cycle of granulocytes in rats.


Protein and free amino acid changes in different heterozygotes of Drosophila melanogaster Meigen in the course of ontogenesis.


The effect of night temperature on germination, carbohydrate and nitrogen metabolism of bean (Vicia faba) seedlings.


The development of the innervation and the musculature of wings innervated by thoracic nerves.


Functional adaptation of thoracic spinal cord segments in the newt.


The anatomical pattern of the so called osteonecrosis of big joints.


[Correction of late sequelae of fractures with injuries of the distal tibial epyphisis].


The relation between the frequency and the pitch of the esophageal voice.


A cinefluorographic observation of the tongue in esophageal speakers.


On the piriform recesses and their acoustic effects.


A comparison of rapid electrophoretic and chromatographic methods for the investigation of common histological dyes.


A modification of the histochemical fluorescence method for the improved localization of 5-hydroxytryptamine.


5-hydroxytryptamine in the enterochromaffin cells of the guinea pig alimentary tract.


On the histochemistry of epimerases. II. Hydroxyproline-2-epimerase.


Atraumatic arteriovenous anastomoses in the leg and foot. Diagnostic and therapeutic observations.


Prophylaxis for thrombosis in obstetrics.


The debatable value of flavonoids in the venous insufficiency of the legs.


The structure and development of marsupial enamel tubules.


RNA synthesis in the nucleolus of Chironomus Thummi, as studied by high resolution autoradiography.


Changes in the fine structure of the human testicular interstitial cells after treatment with human gonadotrophins.


Reutilization by maternal and embryonal cells of nuclear materials from H3-thymidine labeled lymphocytes introduced into the lumen of intestine of rats.


An electron microscopical study of cell contacts in the seminiferous tubules of some mammals.


A system of screening for the presence of a number of common drugs. A method is described to provide a rapid screening technique for the presence of barbiturates, glutethimide, carbromal, meprobamate, salicylate, phenothiazine derivatives, bromide, carbon monoxide, and alcohol. Phenothiazines are detected by a spot urine test. The first four drugs are identified, within 60 minutes of blood collection, on thin-layer chromatoplates of microscope slide dimensions. The estimations of bromide, salicylate, carbon monoxide, and of alcohol levels are started in that period so the overall time for the screening is less than two hours, and the amount of blood required is only 10 ml.


Duration of the cell cycle of germinative cells in plerocercoids of Diphyllobothrium dendriticum.


The R & D information gap or the social science of science and social development.


Experimental studies on the pathogenedis of drug induced agranulocytosis.


An evaluation of granulocyte transfusions.


The use of radiosulfate to evaluate myelocyte kinetics in the dog.


The role of the spleen in destruction of erythrocytes.


Red cell destruction by iso-antibodies.

Red cell destruction by iso-antibodies.


The kinetics of lymphocyte production in the normal and neoplastic thymus.


Antagonism between lymphoreticular and myelocytic cytokinetics.


Mechanisms controlling homeostasis of neutrophilic leukocytes.


The production of monocytes and related cells.


Light and electron microscopy of granules in the toad choroid plexus.


Electron microscopy of resorbing surfaces of dental hard tissues.


Special somatic spine pynapses in the ciliary ganglion of the chick.


The effect of adrenaline and acetylcholine on the hypothalamic-hypophysial neurosecretion in the rat.


Quantitative comparisons between the karyotypes of Australian marsupials from three different superfamilies.


Supernumerary chromosomes in the human bed bug, Cimex lectularius Linn. (Cimicidae: Hemiptera).


Karyotype variation in dermestid beetles.


The effects of x-rays on the chromosomes of locust embryos. IV. Dose-response and variation in sensitivity of the cell cycle for the induction of chromatid aberrations.


The effects of x-rays on the chromosomes of locust embryos. 3. The chromatid aberration types.


Congenital mitral stenosis: report of three surgical cases and a review of the literature.


Incidence and significance of argentaffin and paneth cells in some tumours of the large intestine. The incidence of argentaffin and Paneth cells in epithelial tumours of the large intestine was investigated. Argentaffin cells were found in adenomatous polyps, villus adenomas, polyposis coli, Peutz-Jehgers' polyps, juvenile polyposis, and adenocarcinomas. Paneth cells were not found in metaplastic or juvenile polyps. The crypt unit was destroyed in neoplasia and argentaffin and Paneth cells occurred either as a result of sequestration or were taking part in the neoplastic process. The crypt unit was retained in the disorders of epithelial growth. The identification of argentaffin and Paneth cells enabled the crypt to be defined and thus provided a useful, practical aid in the differentiation between neoplasms and disorders of epithelial growth.


Acute necrotic myelitis and perivenous encephalomyelitis associated with hypertension and renal infection. The case reported showed acute necrotic myelopathy and acute perivenous encephalomyelitis against a background of renal infection, malignant hypertension, and a history of injury. Death from renal disease and pneumonia halted the neurological pathology in the acute stage, thus allowing a more detailed histological examination than is possible in the later stages. The pathogenesis of acute necrotic myelopathy, together with the effects of oedema and vascular compression in the cord, are discussed briefly.


Lipofuscinosis of the gastrointestinal tract in man. Three illustrative cases of lipofuscinosis of the gastrointestinal tract are presented. The nature and significance of this condition are discussed. When the pigment is found in surgical biopsy material steatorrhoea, hypoalbuminaemia, and vitamin E deficiency should be excluded. It is probable that this type of lipofuscinosis is a manifestation of vitamin E deficiency in man.


Significance and interpretation of laboratory tests in pulmonary aspergillosis. The significance of the isolation of Aspergillus fumigatus from sputum may be difficult to interpret because of the frequent occurrence of this fungus in the atmosphere. Criteria are given for classifying positive sputa into two groups, ;fungus scanty' and ;fungus abundant', on the basis of cultural and microscopical findings. A relationship between sputum findings thus classified and the occurrence of Aspergillus antibodies in the patient's serum is demonstrated. The diagnostic importance of direct microscopical examination of sputum is noted. The precipitation patterns of sera to the unstandardized antigenic extracts of A. fumigatus at present available vary greatly. An arbitrary but practical classification of sera is suggested, based on the ;reactivity', or number of precipitation lines produced, and the ;range', or number of antigenic extracts with which the serum reacts.


Further observations on inclusion-bearing cells in urinary sediment in infectious diseases. A study of the cytology of the urinary sediment in 43 patients with known viral diseases has revealed a variety of inclusion-bearing cells in 28.The morphology of the cells suggest that the changes recorded may be due to the viral infections, at least in some instances, bearing in mind the findings of workers quoted in our 1964 report that cellular changes very similar to those induced by virus infections can be initiated by non-viral stimuli. Multinucleate giant cells are occasionally found in chickenpox, measles, herpes simplex infection, and in mumps.


Platelet adhesiveness in diabetes mellitus. Platelet adhesiveness has been assessed on whole blood from a series of 34 diabetics and 50 control subjects using adenosine diphosphate (A.D.P.) and by adherence to glass microspherules (ballotini). Using both techniques it was possible to demonstrate a significant increase in platelet adhesiveness in the diabetic patients.


Semi-automated method for the determination of free fatty acids in plasma. A semi-automated method for the determination of free fatty acids in plasma based on Mosinger's manual method (Mosinger, 1965) is described and the results of a comparison with Dole's titrimetric method (Dole, 1956) are presented. There is almost perfect correlation between the two methods, and the automated technique is simple, reliable, and significantly more accurate and precise than the titrimetric method.


Fatal transfusion reaction due to Serratia marcescens. A fatal blood transfusion reaction due to contamination of the blood by Serratia marcescens is described. The diagnosis and treatment of such cases is described briefly. The importance of teamwork in all concerned with blood transfusion is stressed.


Red blood cell abnormalities in cardiac valvular disease. Nineteen patients with morphological abnormalities of the red blood cells are described, and these formed approximately 3% of the total cases of cardiac valvular disease. In two patients the abnormal blood film developed after the insertion of an aortic and mitral valve prosthesis respectively, but in another two patients the abnormal blood film was corrected by aortic valve surgery. Anisopoikilocytosis may have been associated with microangiopathic haemolytic anaemia in one patient, but in the others the cardiac valvular disease was severe and other mechanical factors were not present. The mitral valve was involved in 16 patients and the aortic valve in eight. Elliptocytosis was the only abnormality in 11 blood films, schistocytes and burr cells were present in seven, and in three there were a few microspherocytes. Family studies in seven patients produced evidence of hereditary elliptocytosis in three. Anaemia was present in only two patients. One of these had infective endocarditis, and the other developed overt haemolytic anaemia following the replacement of a diseased mitral valve by a Starr-Edwards prosthesis. In this latter case there was a transiently positive direct antiglobulin test, and the anaemia and abnormal blood picture were corrected without further surgical treatment. Haemolytic anaemia did not develop in 23 patients after the insertion of an aortic valve prosthesis or homograft. Indirect evidence of haemolysis was obtained in some patients who were not anaemic. There was a reticulocytosis in one third and serum haptoglobins were decreased or absent in over half of the patients tested.


Red cell volume distribution histograms for establishing the normal range using the Coulter plotter model J.


Measurement of red cell diameter by image shearing.


Thyroid disease following the administration of thorotrast. Four cases of thyrotoxicosis are reported among 35 patients who had been given Thorotrast during the investigation of intracranial haemorrhage. For the group as a whole Thorotrast had been given between 11 and 31 years (mean 23.4 years) before this study. Thyrotoxicosis occurred in four patients between six and 17 years (mean 11.8 years) after the injection of Thorotrast. The fact that thyrotoxicosis did not occur in a small control group of patients who had had a subarachnoid haemorrhage and in whom Thorotrast had not been used at angiography suggests that Thorotrast may be of aetiological significance. In view of the known association between thyrotoxicosis and changes in the lymphoreticular system it is possible that the irradiation of this system by retained thorium has resulted in an abnormality of function which renders these patients more liable to the development of thyrotoxicosis.A fifth patient developed non-toxic thyroid enlargement 16 years after Thorotrast angiography.


New automated method for measuring glucose by glucose oxidase. An economical, very sensitive and precise automated method for the determination of plasma glucose by glucose oxidase is presented. At 60 determinations per hour the method required 0.05 ml. of plasma and can conveniently determine glucose levels in the range of 0 to 500 mg/100 ml. Recovery experiments gave mean yields of 99% and, for 100 specimens analysed in duplicate, the precision was 1.24 mg/100 ml.


Mycoplasmas and recurrent oral ulceration. A controlled cultural and serological investigation of mycoplasmas in recurrent oral ulceration was undertaken. No evidence for an aetiological relationship between oral mycoplasmas and this condition was obtained.Mycoplasmas, principally M. orale, were frequently recovered from the oral cavities of individuals with natural teeth, but rarely from edentulous subjects.


Use of diethylenetriamine penta-acetic acid (D.T.P.A.) in the clinical assessment of total body iron stores. As a quantitative test of iron storage the six-hour urinary excretion of iron was measured after the intravenous infusion of the iron-chelating agent diethylenetriamine penta-acetic acid (D.T.P.A.). The value of this test in determining the presence and magnitude of the total body iron stores was assessed in patients with diseases of iron storage. In patients with idiopathic haemochromatosis and in their first-degree relatives with increased iron stores as measured by hepatic biopsy, the result of the D.T.P.A. test fell progressively as iron stores were reduced by venesection therapy. There was a significant correlation between the result of the D.T.P.A. test and the excess iron storage as measured retrospectively by the effects of venesection therapy, and also between the D.T.P.A. test and the unsaturated iron-binding capacity (U.I.B.C.) in these patients. In patients with excess iron stores due to diseases other than idiopathic haemochromatosis (e.g., alcoholic cirrhosis, haemochromatosis associated with refractory anaemia) the D.T.P.A. test demonstrated the presence of excess iron stores, but the results were very variable and did not correlate closely with the U.I.B.C. or the degree of hepatic haemosiderin deposits. Unexpectedly high results for the D.T.P.A. test were found in some patients with iron-deficiency anaemia.


Surgical closure of the incompetent internal os of the cervix during pregnancy.


Some pharmacological studies on cryoepilepsy. I. Preliminary report for quantitative studies.


Mental health and magic beliefs in changing Africa.


The image of the African medicine-man.

The image of the African medicine-man.


The social psychiatry and epidemiology of mental ill health in Israel.


Prospects in cancer epidemiology, and a theory on carcinogenesis.


Comfort and thermal sensations and associated physiological responses at various ambient temperatures.


Life in environs of continuing higher levels of added radiant energy from puberty to death as expressed by mice.


Pathobiology of air pollutants.

Pathobiology of air pollutants.


Effect of x irradiation on the active transport of glucose through the intestine of the rat in vivo.


Crystallographic investigations on quaternary ammonium salts displaying anticholinergic activity.


On the occurrence of monoamines in the cytoplasmic granules of mast cell-like elements in the crested newt.


[Changes of the atriogram in myocardial infarct].


DNA synthesis in oocytes of mammals.

DNA synthesis in oocytes of mammals.


3H-uridine labeling of mouse oocytes.

3H-uridine labeling of mouse oocytes.


Further observations on the luteotropic complex of the hamster.


Progestin secretion by the rat ovary.

Progestin secretion by the rat ovary.


The luteotrophic control of the bovine corpus luteum.


Uterus and duration of pseudopregnancy in the rat.


Immunoassay of human gonadotropin hormones.


Estrogen-receptor interactions in target tissues.


The action of hormonal steroids on the hypothalamo-pituitary-ovarian axis.


Fixation of steroids to receptors.

Fixation of steroids to receptors.


Enzymic and metabolic aspects of hormonally dependent changes in mammary gland function.


Ribonucleic acid and protein synthesis during differentiation of male germ cells in the mouse.


DNA synthesis; proliferation and regeneration of the spermatogonia in the rat.


Erythropoiesis.

Erythropoiesis.


Effect of ligation of pylorus or combined ligation of pylorus and cardia on gastric secretion of normal fasting and of histamine-treated guinea pigs.


Basic requirements of automation equipment.


Histological observations on "reaction in tuberculoid leprosy".


Atypical diabetes mellitus.

Atypical diabetes mellitus.


Paper electrophoresis of serum proteins in diseases.


Triterpenes from the bark of Artocarpus chaplasha.


Chemical investigation of seeds of Stryptocardia tiliaefolia.


In vitro activity of quixalin against V. cholerae.


Hemagglutination test in leprosy.

Hemagglutination test in leprosy.


A case of Entamoeba polecki infection in Calcutta.


Immunization against sarcoma 180 in Swiss mice.


Observations on itch mites recovered from human scabies cases in Calcutta.


Control of nutritional anemias. An urgent national problem.


Clinical enzymology.

Clinical enzymology.


Chemistry of kava.

Chemistry of kava.


Effect of kava in normal subjects and patients.


Ethnographical aspects of kava.

Ethnographical aspects of kava.


Myristica fragrans (nutmeg). Introduction.


The chemistry and psychopharmacology of nutmeg and of several related phenylisopropylamines.


The pharmacology of myristicin and nutmeg.


Vilca and its use.

Vilca and its use.


Chemical constituents and pharmacology of South American snuffs.


Ayahuasca, caapi, yage. Psychotropic properties of the harmala alkaloids.


Chemical constituents isolated from Banisteriopsis and related species.


The psychology, philosophy, morality, and legislative control of drug usage.


Ancient kava ceremony re-enacted on Pahn Kedira, Ponape.


Chlorpromazine-placebo, chlorpromazine-chlordiazepoxide, and chlorpromazine-imipramine treatment of acutely ill patients: symptoms and symptom patterns.


Piper methysticium (kava). The function of kava in modern Samoan culture.


Epidemiology of staphylococcus aureus nasal carriage in a nursery school.


Current status of the susceptibility of some Egyptian body lice to DDT and gamma-BHC.


Further trials for entomological and parasitological evaluation of some insecticides against A. pharoensis in U.A.R. 1965.


The bacteriology of paper and card board produced from paper remnants and rice straw.


Incidence of nutritional deficiencies, goitre and dental caries among school children in Cairo.


Substituting colosigmoid bladder and subtotal colocystoplastics with mucoclasia of remaining trigonum in the treatment of urinary bladder cancer.


On searching for "Mach band type" phenomena in colour vision.


Intramolecular energy transfer in rhodopsin.


On an early stage of rhodopsin regeneration in man.


Early receptor potential of the isolated frog (Rana pipiens) retina.


A spectral sensitivity curve and wavelength discrimination for the turtle crysemys picta picta.


The additivity of large-field colour matching functions.


Brightness discrimination with a stabilised retinal image.


Fluctuations in target visibility as related to the occurrence of the alpha component of the electroencephalogram.


Perception of contour orientation in the central fovea. I: short lines.


Perception of contour orientation in the central fovea. II. Spatial integration.


Functional autonomy in the lateral eye of the horseshoe crab, Limulus polyphemus.


Unitary analysis of retino-geniculate response time in rats.


Stereopsis and anomalous contour.

Stereopsis and anomalous contour.


Distinct spike discharges in the evoked cortical response of the light adapted cat.


Steady-state effects of visual cortex on geniculate cells.


Chemical thyroidectomy and a consideration of larval growth and metamorphosis in Rana temporaria.


Therapeutic usefulness of the association of "adrenocortical extracts, liver extracts and vitamin B 12".


Drug testing in animals for fetal toxicity.


Brewers yeast-induced inflammation in rats: investigation on some humoral and functional changes.


PPP correlations of first and second charge-transfer transitions in molecular complexes of TCNE with aromatic hydrocarbons.


Binoculars and the eye burn problem.

Binoculars and the eye burn problem.


Application of the ring oven technique to the semi-quantiaivedetermination of some antioxidants.


Constituents of the leaves of Artocarpus integrifolia.


Malaria in West Bengal. 3.

Malaria in West Bengal. 3.


Follow up study of thirty-six borderline cases of leprosy.


Trichophyton terrestre in India.

Trichophyton terrestre in India.


Histamine content of the skin in tuberculoid (reaction) cases of leprosy.


Preliminary observations on the activity of pyruvate kinase in Hb. E thalassemia disease.


Enzyme studies on carbohydrate metabolism in some clinical conditions.


Faecal weight and the fat content.

Faecal weight and the fat content.


Dieckmann cyclisation of ethyl 2-n-propylbutane-1, 2, 4-tricarboxylate.


Pharmacology of kava. 1.

Pharmacology of kava. 1.


Pharmacology of kava. 2.

Pharmacology of kava. 2.


Spectrophotofluorimetric determination of 3-carbon fragments and their precursors with anthrone. Application to air pollution.


Complement fixing and skin reactivity after vaccination with the Madrid E typhus vaccine.


A diabetic survey in Assiut school population.


Cholera carriers.

Cholera carriers.


Heights and weights of school children in Cairo as indications of their nutritional status.


Controlled study of the nutritional status of industrial workers exposed to carbon disulphide.


Further trials for entomological and parasitological evaluation of some insecticides against A. pharoensis in U.A.R. II. Entomological and parasitological evaluation of 0.0-dimethyl S (1,2-di-(ethoxycarbamyl-ethyl) phosphorodithioate) (equals malathion).


Further trials for entomological and parasitological evaluation of some insecticides against A. pharoensis in UAR, 1965.


Spreading EMF changes elicited in the cat's cortex by electrical stimulation.


Erythropoiesis-stimulating activity in plasmas of young men living permanently at high altitudes.


Vascular permeability to red blood cells and protein in hemorrhagic shock.


Metabolism of alcohol in high altitudes.


Experimental hemorrhagic shock in animals adapted to high altitudes.


Effect of gonadectomy on gonadotrophin secretion in androgenized rats. Studies in parabiosis.


Influence of reserpine and increased environmental temperature on brain magnesium in toads.


Effect of acetylcholine on the increased renal resistance consecutive to renal ischemia.


Slow potential and impedance changes in the medulla of the cat.


Concentrating mechanism and glomerular filtration rate in the papillectomized dog kidney.


Changes in melatonin concentration in pineal gland in rats exposed to continuous light or darkness.


Two different types of goitrogen blockage: their importance in the neural control of the thyroid gland.


Ovarian hypertrophy after unilateral ovariectomy in immature testosteronetreated rats.


Primary pulmonary hypertension.

Primary pulmonary hypertension.


Morphological conception of scar (narbe) with special reference to scar cancer.


Vanishing tumors and lung cancer in the same patient.


"Oxidative decarboxylation" pathway of succinate oxidation in Ehrlich ascites tumor cells.


Studies on antitumor activity of phenazine derivatives against S 180 in mice. (IV).


Studies on antitumor activity of phenazine derivatives against S 180 in mice. (V). On iodinin and its isomers.


Studies on antitumor activity of phenazine derivatives against S 180 in mice. (VI).


Studies on antitumor activity of phenazine derivatives against S 180 in mice. (VII). On phenazinequinone derivatives.


Autoregulation of organ circulation. Artery dilatation theory on autoregulation.


False cyst of the spleen with calcified wall. Report of a case.


The metopirone test in hypophysectomized dogs with salivary or adrenal gland transplants.


Hemodynamic effects of bradykinin potentiated by a factor contained in the "Bothrops jararaca" venom. Comparative results with eledoisin.


Effects of the optical isomers of isoproterenol upon salivary glands in rats.


Submicroscopical aspects in the differentiation of rat fetal Leydig cells.


Observations on the total organ phosphorus content and radioactive orthophosphate distribution in the alloxanized rat.


Glucose tolerance in partially pancreatectomized Wistar rats after glucose or carbutamide treatment.


Chloride content and distribution in artery wall at different external potassium concentrations.


Dexamethazone and clearing factor.

Dexamethazone and clearing factor.


The characteristic cell reaction in the epithelial layer at the lower surface of the nasal septum during a secondary palate formation.


Chromosome relationships in some North American scarabaeoid beetles, with special reference to Pleocoma and Trox.


Multi-site damage and x-ray-induced lethality in yeast.


Mating designs for estimating direct and maternal genetic variances and direct-maternal genetic covariances.


The occurrence of chromosomal aberrations in pre-spermatocytic cells of irradiated male mice. 3. Sterility and semisterility in the offspring of male mice irradiated in the pre-meiotic and post-meiotic stages of spermatogenesis.


Correlated responses to selection for modifiers of the "hairless" mutant of Drosophila melanogaster.


Nuclear changes of treptional nature in the differentiation of sperm nurse cells in snails.


Meiosis in inversion heterozygotes in Chironomidae.


Spireme karyodieresis: a new type of reductional division.


Synchronous divisions in spermatogonial cells of a snail.


Persistent hyperplastic primary vitreous humor; a finding in a 71-year-old man.


Retinoblastoma in a female aged seventeen years.


Mechanism of the local tetanus induced by intramuscular tetanus toxin.


Slime production in V. cholerae strains.


Identification of seventeen vitamins by circular thin-layer chromatography.


Radiation-induced early changes in size and vascularity of cervical carcinoma. A colpophotographic and clinical study.


Quantitative three-dimensional scintillography of the stomach with technetium(99mTc).


Information transmission in roentgen diagnostic chains. Experimental and clinical studies.


Functional significance of the statistical properties of the retinal discharge.


To model or not to model.

To model or not to model.


A note on some distributions for nonlinear switching elements with finite dead time.


Neural correlates of the optomotor responses in the fly.


Amplitude modulation of the retinal ganglion cell impulses.


Brain and physics of many-body problems.


A simple non-linear theory of color perception and contrast effects.


Immunological concepts in filariasis.

Immunological concepts in filariasis.


Insect resistance to chemicals as a population phenomenon.


Nutritional factors and helminthiasis.

Nutritional factors and helminthiasis.


The absorption and elimination of "Ambilhar" labelled with 14C.


Training aspects of the united states sponsored Aedes aegypti and malaria eradication programs.


Biological activity of surfactants and some chemical intermediates against pre-imaginal mosquitoes.


Thiokol swamp spryte equipped with automatic compressed air spraying units for applying granule and liquid insecticides.


Mosquito control is compatible with and beneficial to agriculture.


Report on agricultural waste water symposium.


A preliminary report on a potential new mosquito control weapon.


A low cost airboat for use in mosquito control.


Insecticidal and naturalistic control of chronomid larvae in lake dalwigk, Vallejo, California.


World-wide mosquito control, a growing public health need.


Spray atomization, application volume and coverage.


Diethylcarbamazine in filariasis control.


Emphasis on control of adult mosquitoes in Florida.


Source reduction through water management.


Primary emphasis on larvicides.

Primary emphasis on larvicides.


Trustees, commissioners and mosquito control.


Civil service system.

Civil service system.


Panel: current trends of unionization and civil service.


A new approach to public relations.

A new approach to public relations.


Panel: possible consolidation of mosquito control agencies into health departments.


Surveillance of aedes aegypti in the U.S. air force.


Emergency measures employed in the control of St. Louis encephalitis epidemics in Dallas and corpus christi, Texas, 1966.


A report on the distribution and biology of tree hole mosquitoes in the western united states.


The anopheles (cellia) leucosphyrus donitz 1901 group in thailand.


Current status of third united states army aedes aegypti eradication program.


The aedes vexans problem.

The aedes vexans problem.


Problems of interaction and density in mosquitoes in relation to aedes aegypti eradication.


Fluctuations in distribution and abundance of aedes vexans (meigen) in salt lake county.


Beneficial effects of research to mosquito control operations.


Mosquito control and the California water plan.


The preparation of ABO blood grouping reagents.


Surgery in the treatment of pulmonary tuberculosis.


Rehabilitation--hospitals and communities.


Autogenous vein grafts for femoro-popliteal by-pass.


The ultrastructure of meninges in vertebrates.


Postirradiation deoxycytidineuria.

Postirradiation deoxycytidineuria.


Ontogenesis of external deltoid muscle formation in man.


Changes of the thickness of the muscle fibre following various types of denervation in newborn and young rats.


On the mechanism of sexual differentiation of the rat hypothalamus.


Circadian rhythms in simulated and manned orbital space flight.


Tumorigenesis in the androgen-sterile rat: reciprocal incidence of carcinogen induced-mammary gland and ovarian tumors.


Dietetics.

Dietetics.


Acute poisoning.

Acute poisoning.


Diagnostic ultrasonics.

Diagnostic ultrasonics.


Diabetes.

Diabetes.


The medical witness.

The medical witness.


Histopathology of lupus erythematosus of the scalp.


Interruption of hypoglicaenic coma by aminoacids infusion.


Carbon-skeleton chromatography for the qualitative identification of selected insecticides.


Study for eye complaints among workers in glass wool industry.


Tetanus prophylaxis. Experimental assay in horses, with penicillin and tetanus antitoxin.


Mycotic infections of the cornea.

Mycotic infections of the cornea.


Hamycin in experimental keratomycosis.

Hamycin in experimental keratomycosis.


Mycotic keratitis (experimental & clinical study).


Making and closing of cataract section.

Making and closing of cataract section.


Implantation cyst of the conjunctiva following squint operation.


Hydatid cyst of the orbit.

Hydatid cyst of the orbit.


Solitary plasmocytoma of conjunctiva.

Solitary plasmocytoma of conjunctiva.


Heterophoria and convergence insufficiency.


Bacterial flora in acute conjunctivitis.


Improved stenopic slit for finding the optimal site for optical iridectomy.


Eale's disease followed by granulomatous anterior uveitis. Case report.


Multiple emboli in central retinal artery following cavernous sinus thrombosis.


Meibomian carcinoma.

Meibomian carcinoma.


Myxoma of the orbit.

Myxoma of the orbit.


Sub-conjunctival saline as test and treatment for ocular malingering.


Physiological considerations from ocular changes in hypothermia during cardiac surgery.


Rapid eye surgical techniques.

Rapid eye surgical techniques.


Screening of 1,000 cases for the incidence of simple glaucoma over the age of 35 years.


Bilateral lymphoid infiltration of the conjunctiva.


Ocular involvement in xeroderma pigmentosum.


Developmental retinal detachment.

Developmental retinal detachment.


Pseudoneuritis with optico-ciliary veins.


Solitary ulcer of the rectum.

Solitary ulcer of the rectum.


Three cases of Waterhouse--Friderichsen syndrome.


Bilateral dislocation of the hips.

Bilateral dislocation of the hips.


The early management of the severely injured.


Cervical spondylosis.

Cervical spondylosis.


Preventive treatment of the consequences originated by lesions in the cremaster muscle.


Acute pharyngeal obstruction.

Acute pharyngeal obstruction.


Myocardial infarction.

Myocardial infarction.


Fractured pelvis with ruptured urethra.

Fractured pelvis with ruptured urethra.


Ruptured subclavian artery--sutured.

Ruptured subclavian artery--sutured.


Crushed legs. Two cases.

Crushed legs. Two cases.


Johne's disease in cattle and vaccination.


The Mitragyna species of Asia. 8. The alkaloids of the leaves of Mitragyna javanica var. microphylla Koord and Valeton.


Chemical examination of the fixed oil from the seeds of Cordia myxa.


Amber night driving spectacles.

Amber night driving spectacles.


Is blind litholapaxy a safe procedure?

Is blind litholapaxy a safe procedure?


Oxygen transmissivity of membranes in contact with the cornea: physiological observations.


Stereoscopic depth associated with cyclotorsional eye movements.


The distribution of aloesin in some South African Aloe species.


Another method of objectively determining visual acuity.


California cancer quack laws: the best is none too good.


Centralisation of applications for nurse training. 1.


Origin and formation of perithecia of Claviceps paspali Stev. et Hall.


Nucleotides of microorganisms. 13. A synthesis of adenylosuccinic acid.


Research on the alkaloids of Strychnos. XVI. The alkaloids of Strychnos mitscherlichii Baillon and Strychnos gardneri A. DC.


Pathological and public health aspects of aflatoxicosis.


A basic approach to the development of drugs.


Dermatoglyphic studies in Turner's syndrome.


Testicular maturation in adrenal hyperfunction.


A simple technique for separation of cortisol metabolites by thin-layer chromatography and its application for the measurement of cortisol secretion rate.


Institute of Obstetrics and Gynaecology of the University of Florence.


Potassium contractures in frog's isolated single fibres.


Immunoassayable insulin and glucose tolerance in non-obese and obese subjects.


Community decision-making concerning water fluoridation.


The relationship between circadian sleep and gamma-hydroxybutyrate (4 HB) in brain.


Lipoprotein responses to orally given enzymes.


Acute cardiac failure in the newborn due to thiamine deficiency.


The inhibition of bromelain.

The inhibition of bromelain.


Hyperresponsiveness to metyrapone.

Hyperresponsiveness to metyrapone.


Biochemical studies on the resolution of experimental inflammations in animals treated with bromelain.


A method for quantitative estimation of the central depressant effect of neuroleptics on the spontaneous motility of rats.


Bilateral congenital anophthalmos (a case report).


Hypothermia following prostatectomy.

Hypothermia following prostatectomy.


An audiometric survey of a Canadian armoured regiment. A follow-up to the 1963 report.


The team approach to the management of skin cancer.


Concomitants of smoking among high school students.


Isolation of coagulant and anticoagulant principles from the venom of Agkistrodon acutus.


A toxin secreted by the soapfish Rypticus saponaceus. A preliminary report.


Collagenolytic activity of snake and spider venoms.


Purification of the lethal fraction of the venom of the stonefish Synanceja horrida (Linnaeus).


Poisoning by the mushroom Clitocybe olearia Maire.


The venom apparatus of Conus magus.

The venom apparatus of Conus magus.


First-aid for snake venom poisoning.

First-aid for snake venom poisoning.


Cancer and evolution.

Cancer and evolution.


Experimental model of rheumatoid arthritis.


Age determination of "Rynchosciara angelae" larvae.


Melanosis coli.

Melanosis coli.


Rotational viscometry by torque relaxation at low shear rates with application to biological systems.


Laminar regime transition for blood flow in tubes.


The influence of electrokinetic charge and deformability of the red blood cell on the flow properties of its suspensions.


Experimental clostridial oil emulsion vaccines.


Effect of slip on the rheology of a composite fluid: application to blood.


A theory for the static elastic behavior of blood vessels.


Blood flow in non uniform tapered capillary tubes.


Mechanical properties of skins, hides and constituent fibres.


A viscometer for the study of blood.

A viscometer for the study of blood.


Psychology of aging.

Psychology of aging.


Stress reactions in old age.

Stress reactions in old age.


The psychopathology and neuropathology of senile and presenile psychoses.


Comparative pharmacotherapy of the aging psychotic patient.


The social aspects of senescence.

The social aspects of senescence.


Study of a hemagglutination inhibitor from HeLa cells.


The effect of mutation on fitness in a system of two co-adapted loci.


Pericentric inversion in a group D chromosome (13-15) associated with amenorrhea and gonadal dysgenesis.


Neighbourhood knowledge and the distribution of marriage distances.


Inherited quantitative variations of human phosphogluconate dehydrogenase.


Electrophoretic variants of human 6-phosphogluconate dehydrogenase: population and family studies and description of a new variant.


On the effects of natural selection on correlations between relatives.


A comparison of some properties of human red cell acid phosphatase in different phenotypes.


The cytological behavior of a human ring-chromosome.


A chromosome survey of induced abortuses in a Japanese population.


The effects of x-rays on the chromosomes of locust embryos. IV. Dose-response and variation in sensitivity of the cell cycle for the induction of chromatid aberrations.


Circular mitochondrial DNA from Xenopus laevis and Rana pipiens.


The effects of x-rays on the chromosomes of locust embryos. 3. The chromatid aberration types.


Complex sex-determining mechanisms in three species of South American grasshoppers (Orthptera, Acridoidea).


Chromosomes of five artiodactyl mammals.


An interchange which raises chiasma frequency.


Leprosy and ABO blood groups.

Leprosy and ABO blood groups.


Ovarian dysgerminoma in three generations?


Combination of spherocytosis and a variant of beta thalassaemia ('isolated raised Hb A2').


A familial variant chromosome in the 13-15 group.


A patient with 45XO-48XYYY mosaicism.

A patient with 45XO-48XYYY mosaicism.


Chromosome mosaicism in a mentally retarded mother and her daughter.


Ring chromosome 18 in a patient with multiple anomalies.


Hydronephrosis in mouse, rat, and man.

Hydronephrosis in mouse, rat, and man.


Chromosomes of human endometrium.

Chromosomes of human endometrium.


High incidence of haemoglobin G Accra in a rural district in Jamaica.


Serum alkaline phosphatase types in North American indians and negroes.


EEG studies of 100 healthy adults--changes evoked by deep breathing.


Abnormal manifestations in resting EEG recordings of healthy persons.


Cancer of the uterine cervix in pregnancy, after delivery and after miscarriage.


Sensibilization of guinea-pigs with cow's milk as a model of sudden death in infants and small children.


Topical problems of early diagnosis of ovarial tumors.


Difficult decannulation in children.

Difficult decannulation in children.


Remarks on attempted suicide.

Remarks on attempted suicide.


Changes of intermediary metabolism in obese persons and their relation to atherosclerosis and to primary cause of ageing.


Inborn errors of lipid metabolism. 13. Familial hypercholesterolemic xanthomatosis. A review of the genealogical tree of 142 patients.


The course and termination of neocortical, commissural fibres within the parietal cortex of the cat brain.


Hypothalamo--reticular conections in the rat.


Clinical diagnosis of anicteric obstruction of bile ducts.


A sociological view of normality.

A sociological view of normality.


Psychiatric perspectives on normality.

Psychiatric perspectives on normality.


On the psychic economy of developmental processes.


Normal adolescents. Interview strategy and selected results.


Children who work.

Children who work.


Classification of body messages.

Classification of body messages.


Understanding normal psychological function. Contributions from schizophrenia.


Normality viewed as a system.

Normality viewed as a system.


A philosophical discussion of normality.


Psychiatry. Why "medical" or "social" model?


Organic brain syndromes. Prognostic significance in general medical patients.


Interaction measurements in psychiatric patients with early total deafness.


The first course in psychiatry. Some contributions to general medical education.


Characterization of the antidiuretic factor in the lysate of V. cholerae.


Vital capacity in young Indian adults.

Vital capacity in young Indian adults.


Histamine content of albino rat uterus during estrous cycle and early pregnancy.


Peak flow rate in Indians.

Peak flow rate in Indians.


"Brain drain"--an analysis.

"Brain drain"--an analysis.


Role of 5-hydroxytryptamine in toxaemia and abortion.


The use of the physical efficiency tests in the evaluation of physical improvement after a military course involving severe physical strain.


Effect of externally applied load on the work done by the isolated heart.


A study of serum alkaline phosphatase in healthy Indians.


Restoration of plasma volume under hypothermia in dogs.


Some local anaesthetics in experimental cardiac arrhythmias.


Short communication. Some simple laboratory devices.


Pharmacological experiments with benzoquinones.


Melasma and other skin manifestations or oral contraceptives. Pigmentary anomalies are among the least serious but most frequent skin changes resulting from oral contraceptive use.  A pseudo "mask of pregnancy" called chloasma or melasma may be produced.  It is a blotchy hyperpigmentation of the face which can be a disfiguring cosmetic and emotional problem.  Melasma most often appears 1-4 months after taking the pill.  Of 13 such patients closely studied, melasma of pregnancy had previously been present in 10.  Only minimal improvement was noted in 7 even up to 4 years after stopping the drug.  Histological examination of 10 biopsy specimens showed normal appearing epidermis with pigment in the basal cell layer of the skin.  Of 199 patients taking oral contraceptives in one study, 24% had melasma; of 212 patients in a second study, 29% developed this problem.  A history of temporary melasma during pregnancy is an important predictor.  Reduced exposure to sunlight is recommended.  Use of a hydroquinone cream as a bleaching agent results in only slight improvement.  Changing the type of pill has had little effect but reducing the amount of progesterone may help.  Other skin manifestations with oral contraceptives include: 1) acne vulgaris, which may be improved or aggravated; 2) alopecia or diffuse thinning of the entire scalp hair, which may be reversible; 3) treatment of aphthous stomatitis, which  is controlled by estrogen therapy; and 4) erythema nodosum, which subsides when oral contraceptives are stopped.  Urticarial reactions represent an allergic response to special drugs.


Pseudo-carcinoma of the cervix in patients who are taking oral contraceptives. During the past 2 years over 30 tissues received at the Armed Forces Institute of Pathology have included distinct polypoid cervical lesions not previously seen.  These lesions resemble cervical carcinoma and about 30% have been so diagnosed by contributing pathologists.  They have occurred almost exclusively in women aged 19-38 years of age receiving oral progestinlike contraceptives.  Most patients were under age 30.  No single preparation has been correlated.  Most patients had been taking the drugs for at least a year.  Clinically the lesions were asymptomatic, discovered during routine examinations, and showed a small polypoid growth extending from the cervical canal.  Follow-up in 10 cases confirmed that these are benign hyperplasias.  Limited evidence in 3 cases suggests they may regress following cessation of the drugs.  The appearance differs from polypoid lesions often found in the cervices of pregnant women and also from those lesions interpreted as adenocarcinoma.  That the recent occurrence of these lesions may be due to reduced dosage of progestinlike agents used is suggested.  A reduction in the antiestrogenic effect of the component may have resulted.  They are considered to be without malignant potential.


Clinical criticism of the oral contraceptive pills. A physician's experience with complications associated with oral contraceptive (OC) use is presented.  Severe depression, including fear of suicide, occurred in 8 patients after they had begun medication.  Menstrual disorders such as metrorrhagia, oligoamenorrhea, and amenorrhea were present in 4 women.  Monilial vulvovaginitis resisted treatment in 11 patients until OC therapy was discontinued.  9 cases of pseudodecidual reaction of the cervix were observed.  Vascular accidents occurred in 4 patients.  There were 2 cases of chloasma and 1 case of vitreous bodies in the posterior chamber of the eye.  The importance of maintaining records on complications encountered during oral contraceptive use for future study is emphasized.


Should nullipara and infertility patients be given oral contraceptives? Some adverse effects of oral contraceptives (OC) on a woman's reproductive life are discussed.  Changes in ovarian tissue in 10 women treated for 1-3 cycles with norethindrone-mestranol were reported to include increased fibrosis, cysts, hypervascularity, degeneration of the germinating follicles, and decreased luteinization.  It is possible that such damage in a sensitive patient will result in permanent amenorrhea with an atrophic endometrium once the OC regimen is discontinued.  Several cases of amenorrhea of more than 4 years' duration in young women who had discontinued OC therapy are noted.  Scanty bleeding after termination of OC use indicates a changed endometrium and vascular bed.  Another adverse effect of OC use is compensatory atrophy or atrophy of disuse of the ovaries which impairs or may prevent the return of ovulation.  It is recommended that OCs not be prescribed to women with irregular menses or digomenorrhea.  There is no evidence that OCs increase fertility in infertile women.  It was concluded that OCs should not be prescribed to nulliparous or infertile women.


Carbohydrate metabolism and the "pill".

Carbohydrate metabolism and the "pill".


Psychiatric problems associated with oral contraceptives.


Gynecologic radiotherapy.

Gynecologic radiotherapy.


Neurological disorders associated with oral contraceptives. Neurological disorders associated with oral contraceptives (OCs) are discussed.  3 patients suffered headaches and developed dramatic symptoms of cerebral deficit which lasted for hours or a few days followed by complete or nearly complete recovery when OC treatment was stopped.  7 other patients are described, including 1 who suffered clear-cut hypertensive vascular disease without evidence of renal or cardiac disease and 1 with cortical thrombophlebitis.  Most patients had been taking OCs for 2 or more years, although 1 had taken them for only 5 months.  The neurological complications were documented and predictive criteria for identifying women who are likely to develop such difficulties, who require dose observation, and from whom OCs should be withdrawn are provided.


Thyroid disease in pregnancy.

Thyroid disease in pregnancy.


Incidence trends in cancer of the uterus.


Resuscitation in the delivery room.

Resuscitation in the delivery room.


Panel on pelvic congestion syndrome.

Panel on pelvic congestion syndrome.


Epidemiologic and experimental aspects of oral contraceptives. In a review of the action of oral contraceptives in preventing conception, current directions in research relating to the eventual elimination of the estrogenic component were discussed.  The importance of carefully controlled epidemiologic analysis of the various complications of oral contraceptives was stressed.  Such controlled studies have proven the effectiveness of the oral contraceptive and established the greater frequency of thromboembolic phenomena in women taking the pill.  Other areas of interest such as the effectiveness of sequential oral contraceptives and possible carcinogenic effects of the pill have yet to receive controlled long-term study.  10-year study of 20,000-30,000 women in the younger ages will give the definitive information needed but until then judgements about carcinogenic effects are premature.


Nature and nurture.

Nature and nurture.


Metabolism of glycerol in diabetes mellitus.


Effect of a large dose of insulin and of blood sugar level on glucose uptake in tissues of eviscerated nephrectomized rats.


The tolerance to massive doses of insulin in adrenalectomized and cortisol-treated rats.


Effects of 1-beta-phenethylbiguanide (DBI) on the metabolism of the isolated rat fat pad.


Assay of insulin-like activity by the isolated fat cell method. I. Factors influencing the response to crystalline insulin.


Assay of insulin-like activity by the isolated fat cell method. II. The suppressible and non-suppressible insulin-like activity of serum.


Action of testosterone on ventral prostate, dorsolateral prostate coagulating glands and seminal vesicles of castrated alloxan-diabetic rats.


Diabetic retinopathy. I. The assessment of severity and progress by comparison with a set of standard fundus photographs.


Diabetic retinopathy. II. Comparison of disease remission induced by various degrees of pituitary ablation by Y90.


A sensitive double antibody radioimmunoassay for human growth hormone (HGH): levels of serum HGH following rapid tolbutamide infusion.


The role of carbon dioxide and the influence of pH on the insulin stimulated glucose metabolism of isolated cells from rat adipose tissue.


Radioimmunoassay of insulin in urine.

Radioimmunoassay of insulin in urine.