Trends in agricultural aviation. Assessment of the efficiency of aerial sprays.


Trends in agricultural aviation. Assessment of the efficiency of aerial application: use of kaolin-coated targets.


Trends in agricultural aviation. The sampling and sizing of spray drops from water-in-oil emulsions.


Trends in agricultural aviation. Ultra-low-volume spraying.


Trends in agricultural aviation. Possible developments in the use of aircraft and associated equipment.


Noise in industry.

Noise in industry.


Laboratory contribution to occupational health in the chemical industry.


The gem-dialkyl effect. II. A comparison of the kinetic and equilibrium approaches to the selective ketalization of 5 alpha-androstane-3,17-dione with various glycols.


The structure of frenolicin.

The structure of frenolicin.


The synthesis of deamino-oxytocin by the solid phase method.


Synthesis by the Merrifield method of a protected nonapeptide amide with the amino acid sequence of oxytocin.


Biosynthesis of lycopodine.

Biosynthesis of lycopodine.


Recent research developments in diabetes mellitus. 3.


The diabetes supplement of the National Health Survey.


Selected-protein diet in terminal uremia.


Medical care for the aging.

Medical care for the aging.


Distinguishing characteristics of the aging from a clinical viewpoint.


Nitrogen balance and plasma amino acids on low-protein diets.


Distinguishing characteristics of the aging from a sociological viewpoint.


Phenylalanine and tyrosine in vegetables and fruits.


Distinguishing characteristics of the aging from a medical education viewpoint.


Distinguishing characteristics of the aging.


Closing session: summary of issues and action recommendations.


Health care needs of the aging--seminar discussion groups. II. Geriatrics as a special body of knowledge.


Cytological evidence for a relationship between normal hemotopoietic colony-forming cells and cells of the lymphoid system. The relationship between hematopoietic colony-forming stem cells and cells in the thymus and lymph nodes of unirradiated mice has been investigated using a chromosome-marker technique. It was found that a high proportion of cells in the thymus may belong to the same clone as normal hematopoietic colony-forming cells. It was also found that cells belonging to the same clone as colony-forming cells may reach the lymph nodes, and that nodes containing such cells can participate in an immunological response against sheep red cells. Either the precursors of cells in thymus and lymph node are identical with hematopoietic colony-forming cells, or they are both descendants of a common precursor which has not yet been identified. The results are compatible with the view that cells of the hematopoietic system and the immune system may be derived from the same stem cell.


The effect of histocompatibility-2 type on response to friend leukemia virus in mice. Two types of quantitative response to the F-B strain of Friend virus in segregating generations of a cross involving a susceptible (DBA/2 or BALB/c; H-2(2)) and a resistant (C57BL/6; H-2(b)) mouse strain show a marked correlation with the H-2 type of the mice. Essential susceptibility, as determined by the splenomegalic response to high virus doses, is controlled by a single pair of alleles which segregates independently with respect to the H-2 locus. However, relative susceptibility, as determined by the incidence of the splenomegalic response at moderate or low levels of virus dosage, is significantly greater among mice homozygous or heterozygous for the H-2(d) allele than among H-2(b) homozygotes in these populations. In addition, the incidence of recovery from splenomegaly induced by a given level of virus dosage is significantly greater in H-2(b) homozygotes than in segregants of other H-2 types among their littermates. Possible mechanisms responsible for these effects are discussed.


Studies on streptococcal bacteriophages. I. Burst size and intracellular growth of group A and group C streptococcal bacteriophages. Evidence has been presented that the burst size in the Group A and Group C streptococcal phage-host systems are in general similar producing approximately 13 phage particles per infected coccus. The exception was the C1 phage which produced 10 times more virus particles than all the other phages tested. The eclipse period for the A25 phage-host system was found to extend for 34 min, while the C1 phage were found as early as 10 min after infection. Conclusive evidence has been presented indicating that mercuric ions at 2.5 x 10(-6)M concentration have the ability to halt intracellular phage production at any point during the infective cycle of A25 bacteriophages. This blocking action can then be quickly reversed with the addition of reduced glutathione with subsequent completion of the viral cycle.


Antigenic modulation. Loss of TL antigen from cells exposed to TL antibody. Study of the phenomenon in vitro. Antigenic modulation (the loss of TL antigens from TL+ cells exposed to TL antibody in the absence of lytic complement) has been demonstrated in vitro. An ascites leukemia, phenotype TL.1,2,3, which modulates rapidly and completely when incubated with TL antiserum in vitro, was selected for further study of the phenomenon. Over a wide range of TL antibody concentrations modulation at 37 degrees C was detectable within 10 min and was complete within approximately 1 hr. The cells were initially sensitized to C' by their contact with antibody, thereafter losing this sensitivity to C' lysis together with their sensitivity to TL antibody and C' in the cytotoxic test. The capacity of the cells to undergo modulation was abolished by actinomycin D and by iodoacetamide, and by reducing the temperature of incubation to 0 degrees C. Thus modulation apparently is an active cellular process. Antigens TL. 1,2, and 3 are all modulated by anti-TL.1,3 serum and by anti-TL.3 serum. This modulation affects all three TL components together, even when antibody to one or two of them is lacking. aAnti-TL.2 serum does not induce modulation and in fact impairs modulation by the other TL antibodies. The influence of the TL phenotype of cells upon the demonstrable content of H-2 (D region) isoantigen, first shown in cells modulated in vivo, has been observed with cells modulated in vitro. Cells undergoing modulation show a progressive increase in H-2 (D region) antigen over a period of 4 hr, with no change in H-2 antigens of the K region. Restoration of the TL+ phenotype of modulated cells after removal of antibody is less rapid than TL+ --> TL- modulation and may require several cell divisions.


Information value and stimulus configuring as factors in conditioned reinforcement.


Associative structure and the temporal characteristics of free recall.


Stimulus selection in animal discrimination learning.


Role of nonreinforcement-reinforcement sequences in the partial-reinforcement effect.


Resistance to extinction of the continuously rewarded response in within-subject partial-reinforcement experiments.


Visual and haptic form discrimination under conditions of successive stimulation.


Word fragments as aids to recall: the organization of a word.


Comparison of classical conditioning and relational learning.


Sampling distributions and probability revisions.


Backward conditioning: a replication with emphasis on conceptualizations by the subject.


Classical conditioning of the galvanic skin response to verbal concepts.


Mediating associations.

Mediating associations.


Observational learning: a technique for elucidating S-R mediation processes.


Effects of delayed auditory feedback on immediate and delayed recall and recognition.


Minimal and maximal sensory intake and exercise as unconditioned stimuli in human heart-rate conditioning.


Relevant and irrelevant information in concept attainment.


Trace cue position, motivation, and short-term memory.


Anxiety and verbal concept learning.

Anxiety and verbal concept learning.


Development of sets of mutually equally discriminable random shapes.


Shifts in percentage of reinforcement viewed as changes in incentive.


The A-B, B-C, A-C mediation paradigm: the effects of variation in A-C study- and test-interval lengths and strength of A-B or B-C.


Picture memory experiments.

Picture memory experiments.


Medical education--factor in socioeconomic development. The First and Second World Conferences on Medical Education.


Medical education--factor in socioeconomic development. The Third World Conference on Medical Education. Presidental address.


Retroactive inhibition of R-S associations in the A-B, B-C, C-B paradigms.


Social change and scientific advance--their relation to medical education. The effect of social change and population growth on the health status of the nations--their implications for medicine and allied health professions.


Social change and scientific advance--their relation to medical education. The effect of scientific and technological advance on medicine--its implications for medical education.


Medical education and the national structure. Priorities in planning national and community development.


Medical education and the national structure. Priorities in planning the development of health manpower, resources and programs.


Organization of medical education to meet the changing needs of society. Educational objectives, curriculum structure, the student and teacher.


Organization of medical education to meet the changing needs for society. Factors influencing the development of the medical curriculum.


Planning new programs in medical education. Education in the health professions to meet the needs of the nations.


Social change and scientific advance--their relation to medical education.


Planning new programs in medical education. Planning the new medical school.


Medical education and the national structure.


Organization of medical education to meet the changing needs of society.


Planning new programs in medical education.


Medical education in the service of mankind. Proceedings of the Third World Conference on Medical Education New Delhi, 1966.


Medical school tuition levels, 1967-68.

Medical school tuition levels, 1967-68.


Estimating thyroid iodine by activation analysis in vivo.


Modulation transfer function, information capacity and performance criteria of scintiscans.


A simple way to make iron (113mIn) hydroxide particles.


Letter from the president.

Letter from the president.


Characteristics of display systems in scanning and a simple phantom procedure to evaluate over-all scanner performance.


130-I for studying the effects of thyroid-stimulating hormone in patients with thyroid cancer.


Recent advances in radiation therapy.

Recent advances in radiation therapy.


Des-A-pregnanes. Degradation of 11-alpha-hydroxyprogesterone.


Chemistry of aliphatic disulfides. XV. Bisdisulfide peptide derivatives.


Potential folic acid antagonists. 3. Deaza analogs of methotrexate. 3. 1- and 3-Deaza analogs of 2,4-diamino-6-[(n-methylanilino)methyl]pteridine.


Coronary care units.

Coronary care units.


Steroid hormone analogs. 3. The synthesis and stereochemistry of C-nor-D-homoprogesterone analogs.


Isomeric aryl monsulfates of estrogen catechols.


Microbiological transformation of steroids. I. The synthesis of 19-nortestololactone.


Chemical modifications of erythromycin antibiotics. I. 3'-de(dimethylamino)erythromycin A and B.


Synthesis of the eight stereoisomers of a tetrahydrocannabinol congener.


The syntheses of homoproaporphines by phenolic oxidative coupling. II. Separation of two isomeric dienones of homoproaporphines.


Synthesis of deoxyguanylyldeoxyguanosine on an insoluble polymer support.


A convenient synthesis of 2,5-piperazinediones.


Tetrahydropyridines.

Tetrahydropyridines.


Glutarimide antibiotics. 13. Comment on the stereochemistry of streptovitacin-A and E-73.


Steroid hormone analogs. IV. C-nor-D-homoestrone.


2-azido-4-alkylamino-6-alkylamino-s-triazines: a new group of herbicidal triazines.


Microbiological effects of synthetic food colouring matters. Some aspects of the adsorption of aromatic solutes at biological surfaces.


Effects of liming and various forms of oral copper supplementation on the copper status of grazing sheep.


The effect of immobilization stress on the activity of central monoamine neurons.


Stimulation of midbrain raphé neurons: behavioral effects of serotonin release.


Tissue electrolyte alterations with hypertension induced by L-triiodothyronine and salt.


Relationship between hydro-osmotic flow and the inhibited response of the toad bladder to vasopressin.


An intracortical cholinergic inhibitory synapse.


The influence of a tricyclic antidepressive agent (protriptyline) on some of the circulatory effects of noradrenaline and adrenaline in man.


Effect of pentobarbital anaesthesia on the turnover of [3H] noradrenaline in peripheral tissues of cats.


Effect of infusion of prostaglandin E1 on the aggregation of blood platelets in man.


Diurnal changes in brain noradrenalin.

Diurnal changes in brain noradrenalin.


Demethylation of imipramine and antitetrabenazine effect in the catalepsy and ptosis test.


Plasma levels of chlorpromazine and some of its relatively non-polar metabolites in psychiatric patients.


Diagnoss and treatment of fractures of the spine.


Neurological diagnosis and the indications for treatment of paraplegia and tetraplegia, associated with fractures of the spine.


The New Salvation Army Grace Hospital.

The New Salvation Army Grace Hospital.


Sex chromosome abnormalities. How strong is the link with crime?


Mortality Study Committee Related to Surgery and Anaesthesia. Illustrative case no. 6691-1.


Internal version.

Internal version.


Mannitol--an osmotic diuretic.

Mannitol--an osmotic diuretic.


Treatment of malaria.

Treatment of malaria.


Halothane and liver injury.

Halothane and liver injury.


Characteristics of patients discharged against medical advice.


Role clarification and sense for staff in mental hospitals.


The need for experimental research on work behavior and attitudes of schizophrenics.


Use of the Harvard Psychiatric Service by athletes and non-athletes.


Project Head Start: aprons to cover their dirty clothes.


Learning in a lonely place.

Learning in a lonely place.


Life cycle factors in mental illness. A biosocial theory with implications for prevention.


A "therapeutic community" for selected families. New approach to juvenile delinquency?


The community mental health center: concept and commitment.


Social criticism: its bearing on problems of mental hygiene and community pathology.


Emotional problems of everyday life.

Emotional problems of everyday life.


The A-B-C method of crisis management.

The A-B-C method of crisis management.


Training for new mental health roles.

Training for new mental health roles.


Screening evaluation: a solution to the increased demands for outpatient consultation in a mental health clinic.


Necrosis of the cecum due to overdistention. Case report.


Prevention of tuberculosis: a guide for physicians.


The psychiatric hospital as an institution of higher education for patients.


Atrioventricular heart block in a general hospital population.


Constitutional precocious puberty. Case report.


Tumors of the duodenum and jejunum. Case reports.


Adrenocortical responsiveness after alternate-day corticosteroid therapy.


Hereditary tendinous and tuberous xanthomatosis without hyperlipidemia. A new lipid-storage disorder.


Evidence for a phosphorus-depletion syndrome in man.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 8-1968.


Vascular occlusion of the colon and oral contraceptives. Possible relation.


Food, feces and phosphorus.

Food, feces and phosphorus.


Editors in procession.

Editors in procession.


Colitis and contraception.

Colitis and contraception.


"The R&R Law".

"The R&R Law".


Water restriction and serum sodium.

Water restriction and serum sodium.


Prevention and management of poisoning.

Prevention and management of poisoning.


Axillofemoral bypass graft. A safe alternative to aortoiliac reconstruction.


The end run as a ground gainer.

The end run as a ground gainer.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 9-1968.


The Wolff-Parkinson-White electrocardiogram. A follow-up study of five to twenty-eight years.


Ruptured abdominal varix.

Ruptured abdominal varix.


Mechanisms of macroamylasemia.

Mechanisms of macroamylasemia.


Byssinosis in the United States.

Byssinosis in the United States.


Coccidioidin reactions in Italians.

Coccidioidin reactions in Italians.


The clinical problem and management of alcoholism.


The diagnosis and management of heroin addiction.


Some problems of opiate addiction.

Some problems of opiate addiction.


The problem of cannabis dependence.

The problem of cannabis dependence.


The use and abuse of amphetamines.

The use and abuse of amphetamines.


The hallucinogenic drugs.

The hallucinogenic drugs.


Physical dependence on heroin and pentobarbitone.


Shared antenatal care.

Shared antenatal care.


Vaccines in the management of influenza epidemics in schools.


Treatment of psoriasis of the scalp.

Treatment of psoriasis of the scalp.


Compression sclerotherapy in the treatment of varicose veins.


A dermatological survey made in general practice.


Clinical trial of an analgesic compound in general practice.


An experiment in community medicine in general practice.


Four unusual reactions to amitriptyline.


Discussion on adolescents.

Discussion on adolescents.


Current therapeutics. CCXLII. Glymidine.


A liquorice preparation in peptic ulceration.


All in the day's work.

All in the day's work.


Everyday problems in general practice. II. The patient's consent.


Toxicological case records.

Toxicological case records.


A speech and hearing program in Appalachia.


Synthesis of 17-aminopregn-4-ene-3,20-dione.


The isolation of 5-beta-androstane-3-alpha,17-alpha-diol from normal human urine.


Pregn-4-ene-3,6,20-trione: a compound formed by the alkaline oxidation of progesterone and its role in the fluorimetric determination of progesterone.


The metabolism of megestrol acetate (17-alpha-acetoxy-6-methylpregna-4,6-diene-3,20-dione) in women.


Some 2,3-fused diaza-heterocycles of estra-1,3,5(10)-trien-17-one.


Studies on testosterone metabolism. VI. Precursors of urinary androstanediols.


Influence of luteinizing hormone on the aromatization of testosterone by human placenta perfused in vitro.


The synthesis of  6-alpha- and 6-beta- fluoro-17-beta-acetoxyestr-4-en-3-ones.


Classification of steroid alcohols by NMR spectroscopy.


The use of a purine cyclonucleoside for the synthess of a  dinucleoside phosphate.


Early manual communication in relation to the deaf child's intellectual, social, and communicative functioning.


The development and operation of a state accredited high school program in a residential school for the deaf.


Institute of Deaf Professional Persons. Keynote address.


Professional preparation: the deaf college student.


Problems of deaf professional persons.

Problems of deaf professional persons.


Role and responsibilities of deaf professional persons.


Carrying out leadership influences and responsibilities.


Institute of Deaf Professional Persons. Summary.


A sequential scheme for the determination of several fall-out nuclides in water.


Analytical evaluation of gestogens in oral contraceptives.


Enzymatic detection of ten organophosphorus pesticides and carbaryl on thin-layer chromatograms: an evaluation of indoxyl, substituted indoxyl and 1-naphthyl acetates as substrates of esterases.


Determination of aldrin residues in vegetables by the chemical conversion of aldrin to dieldrin.


Determination of trace amounts of copper, zinc and magnesium in aminal feeds by atomic-absorption spectrophotometry.


Bioassay of crude extracts for the factor that prevents second matings in female musca domestica.


Effects of gamma radiation on the fertility of the tórsalo, Dermatobia hominis (Diptera: Cuterebridae).


Source of the ether-soluble organies of stings of the honey bee, Apis mellifera (Hymenoptera: Apidae).


Effects of phosphate concentration on cell division rates and yield of a tropical oceanic diatom.


Obesity.

Obesity.


Therapeutic abortion: a survey with a series from The London Hospital.


Assessment of sympathetic denervation following upper dorsal sympathectomy.


Antibiotic resistance patterns of organisms causing acute urinary tract infections occurring in general practice.


Clinical trial of a ceruminolytic agent in general practice.


Pyrexia of unknown origin.

Pyrexia of unknown origin.


Some dermatological problems of dark-skinned people.


Microembolic pulmonary hypertension in pyogenic cholangitis.


B.C.G. vaccination of children against leprosy in Uganda: results at end of second follow-up.


Carcinoma of prostate: response of plasma luteinizing hormone and testosterone to oestrogen therapy.


Gall stone dyspepsia.

Gall stone dyspepsia.


Hypocholesterolaemic effect of Bengal gram: a long-term study in man.


Gangrene of gall bladder due to arterial embolism.


Cerebellar degeneration in association with carcinoma of the stomach.


Foetal growth.

Foetal growth.


Ibufenac.

Ibufenac.


Emigration of British doctors to United States of America and Canada. Report and recommendations of a Ministry of Health Interview Board on interviews and discussions in North America with British trained doctors.


Pulmonary embolectomy.

Pulmonary embolectomy.


Psychotropic drugs.

Psychotropic drugs.


Use of arteriovenous fistula.

Use of arteriovenous fistula.


Congenital dislocation of the hip.

Congenital dislocation of the hip.


Prevention of Rh-haemolytic disease.

Prevention of Rh-haemolytic disease.


Incidence of diverticulosis.

Incidence of diverticulosis.


Managing the hospitals.

Managing the hospitals.


Cardiac catheterization in the first year of life: an assessment of risk.


Photodermatitis in Indians of Manitoba.

Photodermatitis in Indians of Manitoba.


Pancreozymin secretin test of exocrine pancreatic funtion in cystic fribrosis and the significance of the result for the pathogenesis of the disease.


New Dolichopodidae from Canada, Mexico, and the Western United States (Diptera).


Labelling of fatty acids in foods.

Labelling of fatty acids in foods.


The psychic function of religion in mental illness and health formulated by the Committee on Psychiatry and Religion.


Factors to consider when selecting a convection oven.


II. Parenterals in polyvinyl chloride plastic systems.


Panel discussion: current status of plastics as packaging materials for sterile products. I. Plastics for packaging small volume parenterals.


Self-inspection program raises cleanliness level.


Membrane filtration technique in analysis for particulate matter.


Mechanization of ampul inspection.

Mechanization of ampul inspection.


--new dimension for HAS.

--new dimension for HAS.


Inplant or external laundry service? A careful case study will help decide.


3. Plastics for packaging ophthalmic preparations.


Environmental architecture: a checklist for medical planners.


IV. Current status of plastics for packaging parenterals.


Handling a large influx of patients in a disaster situation.


The admitting department: front line for public relations.


Hospital-based education program aids nonaffiliated community physicians.


Practical experience with particle problems.


Sampling techniques in analysis for particulate matter.


Minnesota hospitals establish hospital pharmacy guidelines.


Control tests in the manufacture of rubber closures.


Development of a materials management program.


Fighting fires in an oxygen-rich atmosphere.


The hospital dietitian in prevention and treatment of obesity.


The fatty acid composition of the retinal vasculature of normal and diabetic human eyes.


Light and electron microscopic study of regional morphologic differences in the processes of the ciliary body in the rabbit.


The effect of ouabain on the rabbit corneal endothelium.


Permeability of the corneal endothelium to nonelectrolytes.


The transport of 14C-alpha-aminoisobutyric acid in galactose cataracts in rats and rabbit lenses incubated in high galactose media.


Training in the basic sciences for ophthalmologists.


Studies on the cornea. VII. Effects of perfusion with a Ca++-free medium on the corneal endothelium.


Acoustic and temporal factors in the evocation of startle.


Aural harmonics: preliminary time-intensity relationships using the tone-on-tone masking technique.


Improvement of hearing ability by directional information.


Receiver-operating characteristics determined under several interaural conditions of listening.


Detection and relative discrimination of auditory "jitter".


Use of noise bands to establish noise pitch.


Hazardous exposure to impulse noise.

Hazardous exposure to impulse noise.


Occlusion effect: unilateral sensorineural hearing loss.


Concepts of perceived noisiness, their implementation and application.


Statistical theory of the speech discrimination score.


Speaker identification based on nasal phonation.


Perception of the range of a sound source of unknown strength.


Similarity measure for automatic speech and speaker recognition.


The reaction of hydroxamic acids with water-soluble carbodiimides. A Lossen rearrangement.


The stereospecific total synthesis of dl-lycopodine.


The synthesis of dl-lycopodine.

The synthesis of dl-lycopodine.


A stereochemically controlled total synthesis of dl-ibogamine and dl-epiibogamine.


A new convenient reagent for peptide syntheses.


On the Hilbert-Johnson procedure for pyrimidine nucleoside synthesis.


A simple trimerization of 2,3-butanedione yielding a selective reagent for the modification of arginine in proteins.


Enzymes of the tryptophan synthetic pathway in Pseudomonas putida. The first four enzymatic activities of the tryptophan synthetic pathway in Pseudomonas putida were found on separate molecules. Gel filtration and density gradient centrifugation experiments did not disclose any associations or aggregations among them. These findings contrast with the situation found in the enteric bacteria, where the first two activities are found in an aggregate and the third and fourth are catalyzed by a single enzyme. Tryptophan synthetase, the last enzyme of the pathway, consists of two dissociable components. The affinity of these components is less in P. putida than is the case in Escherichia coli.


Taxonomy of Azotomonas species.

Taxonomy of Azotomonas species. The ability of two strains of Azotomonas insolita and one strain classified only as Azotomonas species to use molecular nitrogen was investigated by use of several techniques. Molecular (15)N(2) incorporation by growing cultures of Azotomonas was inconsistent and limited. In addition, attempts to demonstrate nitrogen fixation in growing cultures by the radioactive (13)N(2) technique were negative. Experiments were done in which the total nitrogen content of a culture was determined by a micro-Kjeldahl method. None of these experiments resulted in a significant increase in total nitrogen. Attempts to show a diauxie effect, that is, transition from growth on NH(4) (+) to N(2), were also unsuccessful. Nitrogen fixation by cell-free extracts of A. insolita was negative, as determined by reduction of N(2) to NH(3), and reduction of cyanide, of acetylene, and of azide. These negative results suggest that the taxonomic reclassification of the genus Azotomonas should be considered.


Transformability of streptomycin-resistant group H streptococci. Several resistant mutants of a transformable group H streptococcus, strain Challis, were isolated from media containing high concentrations of streptomycin. Mutants SR5a and SR5 exhibited high and low transformability, respectively, when exposed to deoxyribonucleic acid (DNA) from a novobiocin-resistant Challis strain. With similar exposure, mutant SR30 exhibited loss of transformability. The mutants further differed from the parent strain in time of appearance of optimal competence, and, in the case of SR5 and SR30, total growth was somewhat less than that of the parent. The rapidity with which transformants appeared upon initial exposure to DNA was approximately the same in the mutants and the parent strain. The decrease or loss of transformability of mutants SR5 and SR30 was found to be due to an alteration in capacity to take up DNA. Mutant SR5a (highly transformable) was further differentiated from mutants SR5 and SR30 in that it was somewhat more sensitive to high concentrations of streptomycin. Transformants obtained by treating strain Challis with the three types of mutant DNA, on the other hand, exhibited similar degrees of resistance to increasing concentrations of streptomycin. The additional decrease in transforming ability of mutant SR5a and the loss of transforming ability of mutant SR5 after a second exposure to streptomycin may indicate a stepwise process in the change from transformability to nontransformability. Although streptomycin resistance may not be directly related to inability to transform, results indicate that streptomycin greatly increases the chances of selecting these mutants and also can be of value in serving as a marker in studies of this nature.


Inhibition of oxygen utilization and destruction of ubiquinone by ultraviolet irradiation of Thiobacillus thiooxidans. Ultraviolet (UV) irradiation inhibited sulfur oxidation by cells of Thiobacillus thiooxidans. Sulfur-oxidizing activity decreased as the exposure time to UV light increased. A loss of the ability of cells of fix CO(2) paralleled the loss of sulfur-oxidizing activity. UV light photoinactivated ubiquinone purified from T. thiooxidans. The same percentage of sulfur-oxidizing activity and ubiquinone was destroyed after 15 min of UV exposure. Both the photoinactivation of sulfur oxidation and ubiquinone followed first-order reaction kinetics. The specific rate constants for both photoinactivations were nearly equal. Cells completely inactivated by UV light contained no ubiquinone. Ubiquinone was found to be a component of the cell wall-membrane complex.


Activation of fatty acid synthesis in cell-free extracts of Saccharomyces cerevisiae. Fatty acid synthesis from acetate in extracts of Saccharomyces cerevisiae strain LK2G12 was shown to be stimulated by alpha-glycerophosphate and citrate, and by a number of compounds related to them. Magnesium was shown to stimulate fatty acid synthesis from acetyl-coenzyme A but not from malonyl-coenzyme A, thus indicating the site of stimulation of fatty acid synthesis to be the acetyl-coenzyme A step.


Diacetyl biosynthesis in Streptococcus diacetilactis and Leuconostoc citrovorum. Pyruvate was shown to be the precursor of diacetyl and acetoin in Streptococcus diacetilactis, but dialyzed cell-free extracts of S. diacetilactis and Leuconostoc citrovorum that had been treated with anion-exchange resin to remove coenzyme A (CoA) formed only acetoin from pyruvate in the presence of thiamine pyrophosphate (TPP) and Mg(++) or Mn(++) ions. The ability to produce diacetyl was restored by the addition of acetyl-CoA. Acetyl-phosphate did not replace the acetyl-CoA. Neither diacetyl nor acetoin was formed when the otherwise complete reaction system was modified by using boiled extract or by omitting the extract, pyruvate, TPP, or the metal ions. Free acetaldehyde was not involved in the biosynthesis of diacetyl or acetoin from pyruvate, dialyzed cell-free extracts of the bacteria produced only acetoin (besides CO(2)) from alpha-acetolactate, and acetoin was not involved in the biosynthesis of diacetyl. Only one of the optical isomers present in racemic alpha-acetolactate was attacked by the extracts, and there was no appreciable spontaneous decarboxylation of the alpha-acetolactate at the pH (4.5) used in experiments.


Salinity effect on the maximal growth temperature of some bacteria isolated from marine enviroments. Salinity of the growth medium was found to have a marked effect on the maximal growth temperature of four bacteria isolated from marine sources. Vibrio marinus MP-1 had a maximal growth temperature of 21.2 C at a salinity of 35% and a maximal growth temperature of 10.5 C at a salinity of 7%, the lowest salinity at which it would grow. This effect was shown to be due to the presence of various cations in the medium. The order of effectiveness of cations in restoring the normal maximal growth temperature, when added to dilute seawater, was Na(+) > Li(+) > Mg(++) > K(+) > Rb(+) > NH(4) (+). The anions tested, with the exception of SO(4)=, had no marked effect on the maximal growth temperature response. In a completely defined medium, the highest maximal growth temperature was 20.0 C at 0.40 m NaCl. A decrease in the maximal growth temperature was observed at both low and high concentrations of NaCl.


Proteinase enzyme system of lactic streptococci. 3. Substrate specificity of Streptococcus lactis intracellular proteinase. The substrate specificity of an intracellular proteinase from Streptococcus lactis was investigated in an effort to understand the role of the enzyme in the cell. Peptides in which the N-terminal residue was glycine were not hydrolyzed by the enzyme (exceptions were glycyl-alanine, glycyl-aspartic acid, and glycyl-asparagine), but the peptide was hydrolyzed if the N-terminal residue was alanine. The enzyme also showed activity toward peptides containing aspartic acid or asparagine. Hydrolysis of only the peptide bonds of alanyl, aspartyl, or asparaginyl residues was confirmed by the action of the enzyme on oxidized bovine ribonuclease A- and B- chain insulin. The N-terminal residues of the peptide fragments liberated were identified. The enzyme attacked both substrates only at alanyl, aspartyl, and asparaginyl residues, releasing these as free amino acids. In addition to alanine, aspartic acid, and asparagine, certain other amino acids were liberated from ribonuclease A, but these were accounted for by the relation of their position to alanine, aspartic acid, and asparagine residues.


Use of nystatin to eliminate spontaneous revertants in yeast. Studies of induction of suppressor mutants may be obscured by revertants already present in the treated population. Such revertants, which appear as a minority of prototrophs among auxotrophs, can be eliminated by pretreatment with nystatin before application of the mutagen. Treatment with nystatin, under the proper conditions, decreased the frequency of prototrophs about 30-fold. This is sufficient for studying induced mutation at frequencies close to the spontaneous frequency.


Further electron microscope characterization of spore appendages of Clostridium bifermentans. Two distinct spore appendage types of Clostridium bifermentans, a pinlike appendage and a tubular appendage, were studied by electron microscopy. The pinlike appendage is characterized by a shaft, about 100 A in diameter, which has a lobed caplike structure. The tubular appendage, 500 to 600 A in diameter, is characterized by a hirsute region consisting of small filaments or fibrils. Gross morphology and ultrastructural features of both types are described.


Isolation and chemical structure of the peptidoglycan of Spirillum serpens cell walls. The peptidoglycan layer of Spirillum serpens cell walls was isolated from intact cells after treatment with sodium dodecylsulfate and digestion with Pronase. The isolated peptidoglycan contained glucosamine, muramic acid, alanine, glutamic acid, and meso-diaminopimelic acid in the approximate molar ratio of 1:1:2:1:1. Aspartic acid and glycine were the only other amino acids found in significant quantities. N-terminal amino acid analyses of the tetrapeptide amino acids in the peptidoglycan revealed that 54% of the diaminopimelic acid molecules are involved in cross-linkage between tetrapeptides. This amount of cross-linkage is greater than that found in the peptidoglycan of previously studied cell walls of gram-negative bacteria. The polysaccharide backbone was isolated, after myxobacter AL-1 enzyme digestion of the peptidoglycan, by fractionation with ECTEOLA-cellulose and Sephadex G-100. An average length of 99 hexosamines for the polysaccharide chains was found (ratio of total hexosamines to reducing end groups).


Properties of bacteria isolated from deep-sea sediments. Thirty-eight isolates were subjected to taxonomic analysis by computer. Of the 38 isolates, 31 were from sediment samples collected at depths from 9,400 to 10,400 meters in the Philippine and Marianas Trenches of the Pacific Ocean, and 7 cultures were from seawater samples collected at various depths from surface to 4,000 meters and from several locations in the Pacific Ocean. A total of 116 characteristics were determined for each isolate, coded, and transferred to punch cards. Similarity values were obtained by computer analysis, with the use of two recently developed computer programs. Five distinct phenetic clusters were observed from the numerical analyses. Four of the clusters were identified as species of the genus Pseudomonas, and one, as an aerogenic species of Aeromonas. Group IV was identified as pigmented Pseudomonas fluorescens, and the major cluster, consisting of groups I and II, which merged at a species level of similarity, was treated as a new species of Pseudomonas. The 38 strain data were compared with data for 132 marine and nonmarine strains previously subjected to computer taxonomic analysis. The barotolerant deep-sea strains, with the exception of the deep-sea P. fluorescens isolates, clustered separately from all other marine strains.


Vitamin requirements of psychrophilic species of Bacillus.


Characterization of the C15 branched-chain fatty acids of Corynebacterium acnes by gas chromatography.


Effect of chloride on oxidation of hydroxylamine by Nitrosomonas europaea cells.


Effect of iron nutrition on the bound hydroxylamine content of Mycobacterium phlei.


Fermentation of glucose by Sarcina maxima.


Survival of airborne Mycoplasma as affected by relative humidity.


Coagulase inhibition by heated and unheated bovine anticoagulase serum.


Production of antitoxic immunity by live oral cholera vaccine.


Salt specificity of a reduced nicotinamide adenine dinucleotide oxidase prepared from a halophilic bacterium. Extracts prepared from a halophilic bacterium contained a reduced nicotinamide adenine dinucleotide (NADH(2)) oxidase active at high solute concentrations. The cation requirement was nonspecific, since KCl, RbCl, and CsCl replaced NaCl with little or no loss of activity, and NH(4)Cl was only partially effective. Only LiCl failed to replace NaCl. No specific chloride requirement was observed although not all anions replaced chloride. Bromide, nitrate, and iodide were essentially ineffective, whereas acetate, formate, citrate, and sulfate proved suitable. The presence of sulfate affected the ability of a cation to satisfy the solute requirement. Sulfate enhanced the rate of NADH(2) oxidation when compared with the rate observed in the presence of chloride. Cations which were inactive as chlorides (LiCl and MgCl(2) at high concentrations) satisfied the cation requirement when added as sulfate salts. Although magnesium satisfied the cation requirement, a concentration effect, as well as an anion effect, was observed. In the presence of MgCl(2), little NADH(2) oxidation was observed at concentrations greater than 1 m. At lower concentrations, the rate of oxidation increased, reaching a maximal value at 0.1 m and remaining constant up to a concentration of 0.05 m MgCl(2). Magnesium acetate and MgSO(4) also replaced NaCl, and the maximal rate of oxidation occurred at 0.05 m with respect to magnesium. There was no change in the rate of oxidation at high magnesium acetate concentrations, whereas the rate of NADH(2) oxidation increased at higher concentrations of MgSO(4).


Extracellular collagenase from Trichophyton schoenleinii. The dermatophyte Trichophyton schoenleinii elaborates an extracellular collagenase which is specific for native collagen and gelatin and is separable from an enzyme which is active against Azocoll. The fungal enzyme differs from the bacterial collagenases in its acid pH and small molecular weight. In addition, the fungal enzyme is irreversibly inhibited by ethylenediaminetetraacetic acid, whereas the bacterial enzymes can be restored by divalent cations, such as Mg(++) and Ca(++).


Galactosidase activity of lactose-positive Neisseria. The chromogenic substrate o-nitrophenyl-beta-d-galactopyranoside (ONPG) was hydrolyzed by lactose-positive Neisseria. Eight strains of pharyngeal origin were examined. In culture reactions, seven strains resembled Neisseria meningitidis with the exception that they produced acid from 1% (w/v) lactose. An eighth strain (V8) differed in that it did not form acid from maltose or from 1% lactose. However, acid formation was observed in 10% lactose cultures of strain V8, suggesting that entry of lactose occurred by passive diffusion, rather than as a result of permease activity. The enzymes which hydrolyzed ONPG were produced constitutively by the cells of all eight strains. Thus, specific activity in these strains was not increased by prior exposure to lactose, or to two other possible inducers, isopropyl-beta-d-thiogalactoside or methyl-beta-d-thiogalactoside. Study of cell-free extracts of one strain showed that the enzyme was heat-labile, having a half-life of 10 min at 45 C. The enzyme was unstable at low protein concentrations, but it was protected completely or partially when albumin or manganous ions were added. The enzyme appeared to be a typical beta-galactosidase: alpha-galactosides (melibiose and p-nitrophenyl-alpha-d-galactopyranoside) were not hydrolyzed, activity against ONPG was not dependent upon inorganic phosphate, and galactose was released by cleavage of ONPG. ONPG hydrolysis provided a simple and rapid method for detecting lactose-positive Neisseria.


Comparative effect of temperature on the oxidative metabolism of whole and disrupted cells of a psychrophilic and a mesophilic species of Bacillus. We investigated the influence of temperature, in the range of 45 to 5 C, on the rate of oxidation of glucose and citrate by intact cells and cell-free extracts of psychrophilic Bacillus psychrophilus and mesophilic B. thuringiensis. Both glucose and endogenous oxidation by whole and disrupted cells of the psychrophile decreased more slowly with decrease in temperature than did glucose and endogenous oxidation by whole and disrupted cells of the mesophile. Similar results were obtained for the oxidation of citrate by cell-free extracts. Since substrate permeability is not involved in the oxidative metabolism of the cell-free extracts, we concluded that the internal enzymes of the psychrophile differ from those of the mesophile.


Adsorption and electrophoretic studies of poly(acrylic acid) on calcium sulfate.


Adsorption of short-chain fatty acids and their ions at the oil-water interface.


Transport of ions across lipid monolayers. I. The structure of decylammonium monolayers at the polarized mercury-water interface.


Neutralization of beta-lysin and cationic bactericidal agents by acidic phospholipid. Acidic phospholipids neutralized the antistaphylococcal activity of rabbit, human, and rat serum and purified rabbit beta-lysin as well. Several tissue bactericidal factors and cationic antibiotics were also neutralized. The neutralizing ability of all anionic lipids tested, together with the lack of this ability for the electrostatically neutral phosphatidylcholine, suggested that neutralization resulted from formation of electrostatic complexes between negative charges on the lipids and positive charges on the bactericidal substances. The neutralization of these host defense systems by phospholipids can explain the ability of phospholipids to increase bacterial virulence.


Transport of ions across lipid monolayers. II. Reduction of polarographic currents of Cu(II) by decylammonium monolayers.


Further studies of effects of antibiotics and other compounds on fecundity and mortality of the two-spotted spider mite.


Sexual sterilization of screw-worm flies by N,N'-tetramethylenebis (1-aziridinecarboxamide): influence of route of administration.


Sexual sterilization of screw-worm flies by orally administered 1-[bis(1-aziridinyl)phosphinyl]-3-(3,4-dichlorophenyl)urea: effects of feeding times and concentrations of vehicle.


Integrated house fly control: populations of fly larvae and predaceous mites, Macrocheles muscaedomesticae, in poultry manure after larvicide treatment.


Inhibition of nitrifying chemolithotrophic bacteria by several insecticides.


Some effects of orally administered ruelene on host sheep and two ectoparasites: the yellow-fever mosquito and the rocky mountain wood tick.


Attraction of near-infrared radiation to Aedes aegypti.


Bioassay of insecticides for control of Drosophila melanogaster.


Biochemical genetics of house fly resistance to carbamate insecticide chemicals.


Parathion and methyl parathion residues on cabbage and southernpeas.


Insecticide hormoligosis.

Insecticide hormoligosis.


House fly age as a factor in their response to certain carbamates.


Effects of required rates of responding upon choice. Pigeons' responses in the presence of two concurrently available (initial-link) stimuli produced one of two different (terminal-link) stimuli according to identical but independent variable-interval schedules. Responses in the presence of each terminal-link stimulus produced equal frequencies of food reinforcement, but in the presence of one of the stimuli, food depended upon the emission of a response rate either higher or lower than a specified value (differential reinforcement of rates). The measure of preference, the dependent variable, was the distribution of responses in the presence of the concurrently available stimuli of the initial links. Each pigeon, the responding of which was appropriately controlled by the response-rate requirements in the two terminal-link stimuli, consistently preferred the stimulus not associated with a response-rate requirement.


Auto-shaping of the pigeon's key-peck.

Auto-shaping of the pigeon's key-peck. Reliable acquisition of the pigeon's key-peck response resulted from repeated unconditional (response-independent) presentations of food after the response key was illuminated momentarily. Comparison groups showed that acquisition was dependent upon light-food pairings, in that order.


The distribution of interresponse times in the pigeon during variable-interval reinforcement. Three pigeons' pecks were reinforced on 1- and 2-min variable-interval schedules, and frequency distributions of their interresponse times (IRTs) were recorded. The conditional probability that a response would fall into any IRT category was estimated by the interresponse-times-per-opportunity transformation (IRTs/op). The resulting functions were notable chiefly for the relatively low probability of IRTs in the 0.2- to 0.3-sec range; in other respects they varied within and between subjects. The overall level of the curves generally rose over the course of 32 experimental hours, but their shapes changed unsystematically. The shape of the IRT distribution was much the same for VI 1-min and VI 2-min. The variability of these distributions supports the notion that the VI schedule only loosely controls response rate, permitting wide latitude to adventitious effects. There was no systematic evidence that curves changed over sessions to conform to the distribution of reinforcements by IRT.


Discrimination of brightness differences by rats with food or brain-stimulation reinforcement. Rats were trained to respond to the brighter of two keys. Four animals were trained with food pellets and four with electrical brain stimulation. Each discrimination sequence was initiated when the animal broke a light beam at the rear of the chamber, turning on the key lights and starting a 30-sec reinforcement period. An initial response on the brighter key was immediately reinforced, and further responses on the brighter key were then intermittently reinforced. Any time the dimmer key was pressed, a 30-sec timeout was introduced. During timeout, no response had any programmed consequence. When the reinforcement period or the timeout ended, a new discrimination sequence could be initiated. Daily 1-hr training sessions were conducted, and after seven or eight sessions, all animals were at or near errorless performance levels. The luminance of the brighter key was then systematically reduced, in seven steps, with two 30-min test sessions at each step. Orderly psychometric functions were generated for individual animals. Initial acquisition, once position preferences were broken, was equally rapid for food and for brain-stimulation animals, and the two reinforcement procedures yielded comparable levels of brightness discriminability.


The effects of graduated stimulus change on the acquisition of a simple discrimination in severely retarded boys. Methods were compared for teaching severely retarded boys to discriminate the position of a 0.75-in. black square and to press the response key closest to it. Seven boys were given trial-and-error training; one learned the task. The six boys who did not learn were presented with a program of graduated stimulus changes. All but one acquired the performance, and he was under appropriate control during the program. When he reached the criterion stimuli, he reverted to a position-based response learned during trial-and-error training. Six similar subjects were presented with graduated stimulus training alone. All six learned the criterion discrimination with few or no errors. Both groups were tested for retention of the criterion performance 35 days after training was completed. Two boys who had near-perfect criterion discrimination performances showed no signs of retention after 35 days. These boys had a history of trial-and-error training.


An apparatus for the assessment of the reinforcing properties of odors in small animals.


Pentobarbital anesthesia of albino rats.


A new device for measuring general locomotor activity in instrumental conditioning situations.


Conditioned suppression or facilitation as a function of the behavioral baseline. Rats were exposed to a multiple schedule of reinforcement. During one component, a bar-press was followed by reinforcement only if it occurred between 15 and 20 sec after the previous response. This differential-reinforcement-of-low-rate (DRL) schedule produced a typical slow rate of responding. During the other component, reinforcement followed the first response to be emitted during limited periods of time which occurred at fixed intervals. These fixed-interval schedules with a limited hold produced higher response rates, described as ;interval' or ;ratio-like' behavior. Responding during the DRL component increased in frequency during a tone which ended with an unavoidable shock of low intensity, but decreased during the tone when the shock intensity was raised. The ;interval' and ;ratio-like' responding decreased in frequency during the tone at all shock intensities. Initial acceleration of the DRL responding appeared to be due to adventitious punishment of collateral behavior which was observed between the bar-presses. The more severe conditioned suppression during the fixed-interval components might be the result of the lower probability of reinforcement after any single response.


A continuous recording activity cage.

A continuous recording activity cage.


Secondary reinforcement and number of primary reinforcements. Pigeons' pecks on either of two concurrently available response keys produced secondary reinforcers according to independent one-minute variable-interval schedules. Different secondary reinforcers, in the presence of which the rates of primary reinforcement were equal, were associated with each key. The rate of pecking maintained by each secondary reinforcer varied directly, but nonproportionally, with the number of primary reinforcements given in the presence of the secondary reinforcer.


The effect of host pregnancy on the reproductive capability of the tsetse fly, Glossina morsitans, in captivity.


Function and operation of the cockroach salivary reservoir.


Digestion, emphasizing trypsin activity, in adult simuliids (Diptera) fed blood, blood-sucrose mixtures, and sucrose.


The thermometer as a cause of P. U. O. A report of two cases.


Dietary amino acid and nucleic acid imbalance leading to altered tumour frequency in the adult housefly, Musca domestica.


Carcinoma of Meckel's diverticulum.

Carcinoma of Meckel's diverticulum.


'Cri-du-chat' syndrome.

'Cri-du-chat' syndrome.


Furuncular myiasis caused by warble fly (Hypoderma) larvae in patients from County Cork.


Complications of intravenous infusions.

Complications of intravenous infusions.


The Commission on Higher Education.

The Commission on Higher Education.


A study of the significance of the tuberculin test.


Perinatal and infant mortality rates in Dublin domiciliary deliveries.


Post-exertional myoglobinuria: a case report.


Radiologic seminar LXIX: spontaneous pneumothorax.


Complications of abdominal surgery.

Complications of abdominal surgery.


Compression of the spinal cord by metastatic tumors.


Nuclear magnetic resonance studies of erythrocyte membranes.


On the conformation of yeast transfer RNA.


Molecular weight of the subunits, oligomeric and associated forms of bovine liver glutamate dehydrogenase.


Heats of base pair formation with adenine and uracil analogs.


Mechanism of viral carcinogenesis by DNA mammalian viruses. V. Properties of purified viral-specific RNA from human adenovirus-induced tumor cells.


Physical examination of the heart: auscultation.


The electrocardiogram in appraisal of patients with heart disease.


The hemodynamic appraisal of the patient with cardiac disease.


Nuclear magnetic resonance studies of proton-exchange kinetics of N-methylacetamide and N-acetylglycine N-methylamide.


The solid-state radiation chemistry of selected transition metal chelates of glycine and alanine.


Electrical phenomena associated with the transport of ions and ion pairs in liquid ion-exchange membranes. 3. Experimental observations in a model system.


Value of instrumentation in wastewater treatment.


Chemical and physical comparison of combined and separate sewer discharges.


Design of a modern meat-packing waste treatment plant.


Mechanism of starch removal in the activated sludge process.


Overloaded oxidation ponds--two case studies.


Toxicity evaluation of a technique for introducing dieldrin into water.


Anaerobic lagoon treatment of milking-parlor wastes.


Deep-well disposal of steel-mill wastes.


Perspectives and prospects in rehabilitation.


"...to extend the concept of rehabilitation".


The role of medical schools within the framework of higher education.


New (?) gallbladder. Case report.

New (?) gallbladder. Case report.


Distribution of health services in Missouri: 3. Medical service centers.


Food and diet surveillance.

Food and diet surveillance.


Gross radioactivity in surface waters of the United States, August 1967.


Radioactivity in California waters, July-December 1966.


Pancreatic scanning. Cleveland Clinic experience.


Iodine-131 in bovine thyroids, April-September 1967.


Radioactivity in airborne particulates and percipitation.


Reported nuclear detonations, Janurary 1967.


The status of placental scanning with technetium bound to serum albumin.


Liver scanning with special reference to jaundiced patients.


Suggested biological monitoring for radon daughter exposure.


Neurological allergy.

Neurological allergy.


Gamma cameras--advantages and disadvantages.


Late effects among Hiroshima and Nagasaki survivors.


The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling.


Further investigation of the role of selenomethionine se 75 uptake in the diagnosis of lymphoma.


Structure and synthesis of nojirimycin.

Structure and synthesis of nojirimycin.


Scintillation scanning as an aid in the diagnosis of liver disease.


Transformation of cholic acid by the culture Mycobacterium N 1210.


NMR spectra of estrogen catechols.

NMR spectra of estrogen catechols.


The isolation and characterization of hellebrigenin 3-acetate and hellebrigenin 3,5-diacetate, bufadienolide tumor inhibitors from Bersama abyssinica.


The strucutre of polyoxin C.

The strucutre of polyoxin C.


The crystal structure of pyrrolnitrin.

The crystal structure of pyrrolnitrin.


Biosynthesis of piperidine alkaloids.

Biosynthesis of piperidine alkaloids.


The structure and configuration of caseamine and caseadine two novel tetrahydroprotoberberines from Corydalis caseana A. Gray.


The identification of ciclacidine an antibiotic from Streptomyces capoamus sp. nov.


The synthesis of codeine and morphine glucuronides.


Total synthesis of kanamycin-A.

Total synthesis of kanamycin-A.


Group practice conference report may aid unwanted legislation.


Regional Medical Program of Texas described as cooperative venture.


Leprosy in Texas.

Leprosy in Texas.


New safety laws require vision tests for drivers.


Reducing mortality in ulcer surgery.

Reducing mortality in ulcer surgery.


Mallory-Weiss syndrome.

Mallory-Weiss syndrome.


Technites peri lalias.

Technites peri lalias.


Traumatic rupture of the gallbladder.

Traumatic rupture of the gallbladder.


The natural history of breast cancer.

The natural history of breast cancer.


The premarital consultation.

The premarital consultation.


Cytology of the blood of domestic animals--the numbers of blood elements in normal animals.


Clinicopathologic conference.

Clinicopathologic conference.


A reagent for the detection of ketopentoses and ketopentose phosphates on chromatograms.


A method for the determination of the relative specific radioactivity of [3H] proteins in acrylamide gel.


Separation and identification of benzothiadiazines in commercial formulations by thin-layer chromatography and infrared spectroscopy.


Separation and quantitation of saccharides by ion-exchange chromatography utilizing boric acid-glycerol buffers.


Preparation, isolation, and characterization of a derivative of malonaldehyde.


Separation of diacetyl, acetoin, and 2,3-butylene glycol by salting-out chromatography.


A modified ultrafiltration cell for separating the products of proteolysis.


A simple method for the synthesis of N5,N10-methenyltetrahydrofolic acid.


A modified reagent for dipicolinic acid analysis.


A simple procedure for eluting nucleotides from thin-layer plates.


A simple density-gradient engine for loading large-capacity zonal ultracentrifuge rotors.


An absorption system for collecting dog respiratory CO2.


Determination of leucine aminopeptidase activity with radioactive leucinamide.


Quantitation of hemoglobins A and S separated by starch gel electrophoresis.


Colorimetric determination of inorganic phosphate in the presence of biological material and adenosine triphosphate.


New correction factors for spectrophotometric assay of erythrocyte porphyrins.


Ion-exchange chromatography of nucleotides on polyethyleneimine cellulose columns: analysis of maize grain extracts.


Determination of delta-aminolevulinic acid in plasma.


New technique for continuous-flow centrifugation with banding.


Measurement of 32P activity in a liquid scintillation counter without the use of scintillator.


A convenient method of preparing polyacrylamide gels for liquid scintillation spectrometry.


Assay of intestinal disaccharidases.

Assay of intestinal disaccharidases.


The importance of antibiotics in rearing (nutritional effects).


The use of antibiotics for the preservation of poultry and meat.


The use of antibiotics for food preservation.


Variability of angina. Some implications for epidemiology.


Bronchitis in two integrated steel works. I. Ventilatory capacity, age, and physique of non-bronchitic men.


Symptoms and personality in the diagnosis of physical illness.


Significance of low birth weight in perinatal mortality. A study of variations within England and Wales.


Incidence of congenital abnormalities in Liverpool, 1960-64.


Possible association between maternal virus infections and stillbirths.


Outpatients of a London teaching hospital.


Pilot survey of haemoglobin and plasma urea concentration in a random sample of adults in Wales 1965-66.


Addendum to Daily changes in Ventilatory Capacity in Smokers and Non-smokers.


Trends in hospitalized accidental poisoning.


Mesenteric vascular occlusion. Recovery following extensive resection of small and large intestines.


Peripelvic renal cysts.

Peripelvic renal cysts.


Surgery and corticosteroids. An experimental study.


Diagnosis of cholelithiasis and cholecystitis with special reference to X-ray findings.


Lamprey liver and its bile ducts.

Lamprey liver and its bile ducts.


The use of the vermiform appendix as a fallopian tube. Primary report of success.


Surgical risks among ABO blood groups.

Surgical risks among ABO blood groups.


List differentiation as a function of frequency and retention interval.


Factors modifying renal tubular bicarbonate reabsorption in the dog. 1. Acute experiments were carried out on anaesthetized dogs during metabolic alkalosis produced by I.V. administration of NaHCO(3). Partial constriction of one ureter led to a significant rise in the HCO(3) (-) threshold, beyond the simultaneous value for the other kidney. The magnitude of the increase was not correlated with the reduction of glomerular filtration.2. Stop-flow analysis, following complete unilateral obstruction of urine flow, demonstrated proximal as well as distal tubular reabsorption of bicarbonate. At any given plasma P(co2) the detailed configuration of the concentration changes which developed depended on (a) the presence and concentration of mannitol, (b) the duration of urinary stasis, and (c) the plasma concentration of HCO(3) (-).3. If a solution containing 15% (w/v) mannitol was infused I.V., the HCO(3) (-) concentration in free flow urine was lower than in plasma, and it fell further during arrest of flow in the entire column of trapped fluid. If less mannitol was infused, or none at all, interruption of urine flow led to a striking increase of HCO(3) (-) concentration in the distal portion of the occluded column, and to a fall in the fluid arrested in the proximal segments.4. It was demonstrated that the HCO(3) (-) concentration attained after 2(1/2), 6, or 15 min of urinary stasis at any point in the trapped fluid column was due to the combined effects of water reabsorption and HCO(3) (-) reabsorption which proceeded independently, and with a different time course.5. If mannitol was administered the lowest urinary HCO(3) (-) concentration in the series moved progressively to a more distal location with increasing duration of urinary stasis. When HCO(3) (-) concentration peaks were present in distal fluid they were conspicuous only after short interruptions of urine flow; during extended stop-flow periods they became attenuated, or disappeared. If no mannitol was administered this did not occur.6. Provided the plasma level of HCO(3) (-) was sufficiently elevated, mannitol (15%, w/v) was administered, and the time available for reabsorption was lengthened by ureter obstruction, much larger concentration differences between plasma and trapped fluid developed than the largest that are ever found between the plasma and freely draining urine. The magnitude of the largest plasma-urine (P-U) concentration difference for HCO(3) (-) increased with intratubular ;contact time', and no limiting value was found.7. Potassium concentration in distal occluded fluid fell with prolonged duration of stasis. This was related to the slow and progressive diminution of distal HCO(3) (-) concentration. But if instead of bicarbonate a nonreabsorbable anion, such as phosphate, was the dominant distal anion, K(+) concentration in distal fractions remained high and rose further with time.


Release of noradrenaline from the cat spleen by potassium. 1. Cat spleens were perfused with Krebs-bicarbonate solution by means of a constant flow pump. The amount of noradrenaline released by an injection of potassium chloride solution (3.7M) was measured. The dependence of noradrenaline released by KCl on the ionic composition of perfusion medium was determined.2. In normal cats, the average output was 166 ng following a low dose of KCl (0.2 ml.), and 507 ng following a high dose (0.8 ml.). After phenoxybenzamine treatment, the outputs with both doses were nearly doubled.3. In both normal and phenoxybenzamine treated cats, removal of calcium from the perfusing solution nearly abolished the release of noradrenaline. Replacing the calcium in Krebs solution restored the output. Increasing the magnesium concentration to 20 mM also markedly reduced the noradrenaline output.4. Lowering the sodium concentration to either 25 or 0 mM increased the noradrenaline output by nearly two- to threefold. In solutions with reduced concentrations of sodium, noradrenaline was released over longer periods following KCl injections. In phenoxybenzamine treated cats, reduction of sodium in the perfusing solution also increased the noradrenaline output by nearly twofold following either the low or the high dose of KCl.5. It is concluded that calcium ions are necessary for the release of noradrenaline from post-ganglionic sympathetic nerves following depolarization by potassium ions. It is also suggested that sodium ions are specifically needed for the reincorporation of released transmitter into the sympathetic nerve endings.


Early effects of abrupt reduction of local pressure on the forearm and its circulation. 1. The pressure at the surface of a segment of forearm enclosed in a plethysmograph was abruptly reduced from atmospheric to -20 to -120 mm Hg.2. Forearm circumference (equivalent to the volume of a small segment of forearm (V(f))) was measured with a strain gauge. Pressure was measured in the plethysmograph (P(p)), in veins exposed (P(ve)) and not exposed (P(vne)) to suction, in the brachial artery not exposed to suction (P(bane)) and in forearm tissue (P(t)).3. Reduction of P(p) caused increase of V(f). This was not due to gas evolution, since bubbles would not be liberated at the pressures employed. Nor was increase of V(f) due to venous backflow since P(ve) fell, but P(vne) did not, even with upper arm circulation occluded or when P(vne) was raised by venous occlusion prior to reduction of P(p).4. Reduction of P(p) temporarily arrested venous outflow since P(ve) < P(vne) < P(bane) for 30 sec. With reduction of P(p) 30 sec after occlusion of the upper-arm circulation, P(ve) < P(vne) for > 1 min, indicating that arterial inflow was then minimal.5. Increase of V(f), following reduction of P(p), was therefore due to inflow of arterial blood, of soft tissue or interstitial fluid. Interstitial fluid could flow from regions external to the plethysmograph, or enter as the result of filtration across capillaries. Occlusion of the upper arm circulation was not expected to interfere with motion of forearm soft tissue or the intratissue flow of interstitial fluid. It appears that capillary filtration is small compared with observed blood flow. Therefore subtraction of V(foccl) measured at intervals after reduction of P(p) (upper arm circulation occluded) from V(f) similarly obtained (but upper arm circulation free) appeared to give change of forearm volume due to inflow of arterial blood (DeltaV(b)). V(b), the volume inflow rate of arterial blood during suction, was then obtained.6. Resting forearm flow was 1.8 ml./min/100 ml. in seven normal subjects (average mean arterial blood pressure 86 mm Hg). With P(p) = -90 mm Hg, V(b) was 10.2 ml./min/100 ml. Suction therefore reduced vascular resistance, measured as (P(bane)-P(ve)) /V(b).


The effect of haemorrhage on haemoglobin concentration, blood volume and arterial pressure in kittens and cats. 1. The arterial haemoglobin concentration in kittens less than 24 hr old was inversely related to body weight. There was about twice as much haemoglobin/unit body weight at birth as in adult cats. Haemoglobin concentrations were minimal at 3-6 weeks of age.2. In animals lightly anaesthetized with sodium pentobarbitone, arterial pressure rose from 52 mm Hg at birth in kittens to 133 mm Hg in adult cats. Blood volume decreased from 73 ml./kg at birth to 60 ml./kg in adults.3. When kittens less than a fortnight old were subjected to stepwise blood letting, arterial pressure fell proportionately with blood volume; in older kittens and in cats, arterial pressure was less well maintained at similar proportionate reductions of blood volume than in young kittens.4. The responses to haemorrhage of kittens and cats were compared with those of rabbits similarly treated and with those of adult cats anaesthetized with urethane and chloralose reported in the literature.


Factors influencing noradrenaline uptake by the perfused spleen of the cat. 1. Noradrenaline was infused intra-arterially at the constant rate of 0.51 mug/min for 22 min into the cat spleen perfused with Krebs saline, and the amount appearing in the perfusate was assayed either chemically or on the blood pressure of the pithed rat.2. In normal animals, 34% of the infused noradrenaline appeared in the perfusate, indicating 66% removal by the spleen.3. Neither removal of calcium from Krebs solution nor perfusion with 25 mM-Ca(2+) Krebs solution had significant effects on noradrenaline recovery.4. In spleens perfused with 0 or 50 mM-K(+) Krebs solution the noradrenaline recoveries were not significantly different from the control recoveries.5. Removal of sodium from Krebs solution increased the recoveries to 92%.6. The effect of interference with energy metabolism on noradrenaline recoveries was investigated. Iodoacetate or dinitrophenol alone increased the recoveries only moderately, but combined treatment with both metabolic inhibitors increased the recoveries to 74%.7. If the temperature of the perfusion fluid was reduced to 15 degrees C, noradrenaline recoveries increased to 96%. At 27 degrees C the recoveries were 48%.8. At pH 5.6, noradrenaline recoveries in the venous effluent increased to 63%. At pH 9.0 the recoveries were not significantly different from the control recoveries.9. When (+)-noradrenaline was infused at 0.51 mug/min into the spleen, 55% of the infused amount was recovered in the venous effluent. This recovery is significantly higher than the 34% for (-)-noradrenaline.10. Ouabain and tetracaine increased the recoveries to over 70%, whereas mercuric chloride and insulin had no effect.11. Neither the flow rate nor the size of the spleen correlated with noradrenaline recovery.12. Our results suggest that uptake of infused noradrenaline is energy dependent and has an absolute requirement for the presence of sodium ions in the perfusion medium.


Effect of a local change of membrane resistance on the electrotonic potential recorded nearer to the source.


The activation and distribution of GABA and L-glutamate receptors on goldfish Mauthner neurones: an analysis of dendritic remote inhibition. 1. The sensitivity of the membrane of the cell-body and lateral dendrite of the Mauthner neurone to iontophoretically applied GABA and L-glutamic acid has been investigated in goldfish. The cells were afterwards examined histologically. The results, taken together with physiological observations, help to explain some functional properties of dendritic synapses.2. GABA inhibits by increasing the membrane conductance, and has little effect on resting potential. L-Glutamate depolarizes, and its effects could sum with subthreshold excitatory post-synaptic potentials (e.p.s.p.s) to cause impulse firing. Neither substance was effective when released intracellularly, but only when applied to the outside of the membrane.3. Using a roving double-barrelled micropipette to apply brief iontophoretic pulses very close to the cell, and recording from the cell-body, the sensitivity to GABA was found to be uniform over a region extending from the axon-hillock to about half-way along the lateral dendrite; it then appeared to fall progressively as the drug was pipetted further and further out on the dendrite. The sensitivity to L-glutamate however seemed relatively unaffected by varying the site of application.4. In contrast to this, when the recording electrode was inserted into the same region of the cell where the drugs were applied, then the sensitivity to GABA, like that to L-glutamate, was found to be similar everywhere, including the distal part of the lateral dendrite.5. The antidromic spike, which does not actively invade the lateral dendrite, was used as a convenient test signal for detecting electrotonic decrement as well as changes in membrane conductance. The conductance changes due to small doses of GABA applied to the dendrite could be detected only over relatively short distances (tens of microns). But over these same distances very little decrement of potential change took place.6. The concept of dendritic remote inhibition has been put on a firm experimental basis. It occurs in the Mauthner cell, and is shown to be capable of providing a high spatial selectivity of action. The e.p.s.p.s most affected by it are those generated out on the same dendrite, and it follows that many of the e.p.s.p.s produced far out on other dendrites could well be influenced by it, though to a lesser extent. Least affected are large e.p.s.p.s generated in the cell-body and axon-hillock regions. The synaptic grouping provided by the distal parts of dendrites and their associated nerve endings is discussed.7. The results of a theoretical treatment (Appendix) of the effects of a localized membrane resistance change on electrotonic potentials recorded nearer to the source have been applied to results obtained on the Mauthner cell. The experimentally observed properties of the ;remote inhibition' caused by localized GABA application to the lateral dendrite, accord well with those predicted both for an infinitely long uniform cable and for a cable having a closed end at the region of the conductance change. The possible implications of these results for other central neurones are considered.8. Evidence is adduced showing that the synapses responsible for collateral inhibition in the Mauthner cell include at least part of the group of small nerve endings found on the axon-hillock, cell-body, proximal and distal lateral dendrite. (The latter distally-located endings cause dendritic remote inhibition.) All these regions, some of which certainly have excitatory synapses, thus receive an inhibitory input as well, and are sensitive to both GABA and L-glutamate.9. E.p.s.p.s recorded in the cell-body were reduced by about the same amount as was the antidromic spike when GABA was applied there, but considerably more than the spike when the GABA application was to the lateral dendrite near the origin of the e.p.s.p. Even when the recording was made from the affected region of the dendrite, the e.p.s.p. seemed more sensitive to GABA than was the electrotonically conducted spike. This, and other observations, suggests that GABA may act presynaptically on the excitatory endings as well as post-synaptically.10. The detection of effects, and the recognition of site of action, of drugs applied iontophoretically in the central nervous system is discussed on the basis of the present findings.


The role of sodium and potassium in insulin secretion from rabbit pancreas. 1. Insulin secretion from pieces of rabbit pancreas incubated in vitro was studied in media of different ionic composition and in response to different substances added to the media.2. Experiments were performed which demonstrated that a sodium pump played a role in insulin secretion and that inhibition of the pump by ouabain, or by the omission of extracellular potassium, stimulated insulin secretion.3. A rise in extracellular potassium concentration stimulated insulin secretion independently of changes in the osmolarity or sodium or chloride concentration of the incubation medium.4. The role of extracellular sodium in insulin secretion was investigated. Extracellular sodium was a pre-requisite for insulin secretion stimulated by glucose, glucagon, L-leucine, tolbutamide, potassium or ouabain.5. The presence of 3.3 mM glucose in the incubation medium was not essential for the stimulation of insulin secretion by L-leucine, tolbutamide or ouabain. Glucagon did not stimulate insulin secretion in the presence of 3.3 mM glucose but did so in the presence of 16.5 mM glucose.6. The results obtained in these experiments suggested that a transmembrane sodium flux probably in the beta cell was a fundamental event in the stimulation of insulin secretion by diverse stimuli.


The origin of the initial heat associated with a single impulse in mammalian non-myelinated nerve fibres. 1. A study has been made of the temperature changes associated with the passage of a single impulse in rabbit desheated vagus nerves.2. The initial changes consist of an evolution of positive heat followed by a reabsorption of most of it; i.e. there is a phase of positive and a phase of negative heat production.3. The size of the positive heat, its time of onset, and the time of onset of the negative heat have been measured by an analogue method of analysis. In addition, these parameters, together with the size of the negative heat and the duration of both phases of initial heat, have been studied with the aid of a computer, and also by conventional heat block analysis.4. At about 5 degrees C the measured positive heat is 7.2 mucal/g. impulse. It starts as soon as the compound action potential reaches the thermopile and lasts for about 107 msec.5. This positive heat decreases with increasing temperature, the ratio of heat at 4 degrees C to that at 14 degrees C being 1.86.6. The measured negative heat at about 5 degrees C is 4.9 mucal/g. impulse. It starts 102 msec after the onset of positive heat, and lasts for about 240 msec.7. When the sodium of Locke solution is replaced by lithium the positive heat is reduced by 19%, but the negative heat is increased by 22%.8. In potassium-free solutions the positive heat is hardly affected (increase of 5%), but the negative heat is more than doubled. As a result the nerve may become briefly colder than its initial temperature by about 2 mu degrees C.9. The effect of sodium-deficient solutions on the positive heat is somewhat variable, but the negative heat is consistently diminished.10. Replacement of the chloride of Locke solution by sulphate or nitrate has little effect on the positive heat. The negative heat is reduced in size by 26% and in duration by 22%.11. Replacement of most of the sodium of Locke solution by barium reduces or abolishes the negative heat, and increases the measured size of the positive heat nearly threefold.12. Veratrine (10(-5) g/ml.) produces a nearly tenfold increase in the net positive heat.13. Ouabain (1 mM) and antimycin A (1 mug/ml.) applied for 30-60 min have little effect on the initial heat production.14. Over the temperature range 5-15 degrees C, and for the ionic solution changes described above, there is close agreement in timing between the positive heat and the rising phase of the action potential, and between the negative heat and the falling phase.15. Because of the inevitable temporal dispersion of the action potential over the face of the thermopile, the observed temperature changes are smaller than those which occur at a single point in the nerve close to a stimulating electrode. The corrected value of the positive heat at 5 degrees C is 24.5 mucal/g. impulse, while that of the negative heat is 22.2 mucal/g. impulse.16. The heats of mixing of the ions in solution that interchange during the action potential are much too small to account for the observed initial heats, but an exchange of ions associated with fixed charges might make a significant contribution to the heats.17. The condenser theory, according to which the positive heat represents the dissipation of electrical energy stored in the membrane capacity, while the negative heat results from the recharging of the capacity, appears unable to account for more than half of the observed temperature changes.18. It seems probable that the greater part of the initial heat results from changes in the entropy of the nerve membrane when it is depolarized and repolarized.


Gastric blood flow in anaesthetized cats. 1. The gastric mucosal blood flow has been measured by the amidopyrine clearance technique in anaesthetized cats. The total gastric blood flow has been (a) measured directly and (b) calculated by the Fick principle from the amidopyrine concentrations in gastric arterial and venous blood and the gastric output of amidopyrine.2. Observations on the recovery of added amidopyrine from arterial and venous blood and plasma, and on the rate of transfer of amidopyrine from corpuscles to plasma, support the underlying assumptions of the amidopyrine method of measuring mucosal blood flow.3. If acid solutions are instilled into the stomach the mucosal blood flow of the non-secreting stomach may be measured by the amidopyrine technique.4. Total gastric and mucosal blood flow increased linearly with increase in H(+) secretion, stimulated by histamine or gastrin. The increase in total flow was entirely due to the increase in mucosal flow.5. The relationship between mucosal blood flow and H(+) secretion was the same for histamine and gastrin responses, and was unaffected by maintaining the total flow at a constant level, or by reduction of the circulating blood volume. Increase in blood volume altered the relationship so that there was a greater increment in mucosal blood flow for any increase in H(+) secretion.6. It is concluded that valid observations may be made on secretion and blood flow relationships in acute anaesthetized preparations.


Smiling in schizophrenia.

Smiling in schizophrenia.


The effect of intraventricular injections of noradrenaline, 5-hydroxytryptamine, acetylcholine and tranylcypromine on the ox (Bos taurus) at different environmental temperatures. 1. Noradrenaline, 5-hydroxytryptamine (5-HT), acetylcholine and tranylcypromine were injected or infused into the lateral ventricle of the ox. The effects of these drugs on heart and respiration rates, heat production, rectal, skin and hypothalamic temperatures and skin evaporative loss were measured when the animal was exposed to environmental temperatures ranging from -1 degrees C to +30 degrees C.2. Acetylcholine (0.001-2 mg) had no detectable effect on temperature regulation at 20 degrees C.3. In small doses (0.005-0.05 mg) 5-HT had no detectable effect. Larger doses (2-5 mg) given in a cold environment (-1 degrees C) also had no effect but the same doses given in warm environments (15-30 degrees C) caused increases in skin temperatures, skin evaporative loss and respiratory rate, and decreases in rectal and hypothalamic temperatures.4. Infusion of tranylcypromine (0.107 ml./min of a 1 in 50 solution) in a warm environment (20 degrees C) also caused a decrease in rectal temperature after a delay of 1-1(1/2) hr during which no effects were apparent.5. Noradrenaline (2 mg) had no effect on temperature regulation when injected into animals in a warm environment (30 degrees C). When injected (1 mg) into animals in a cold environment (-1 degrees C) shivering stopped and heat production and rectal and hypothalamic temperatures were decreased.6. It is concluded that intraventricular 5-HT and noradrenaline both cause a decrease in body temperature, and it is unlikely that central temperature regulation in the ox is mediated only by these two substances.


The release of 5-hydroxytryptamine from rabbit small intestine in vitro. 1. A method is described by which the lumen of intestinal segments may be perfused separately and simultaneously under identical conditions of perfusion pressure and temperature, and the rate of appearance of 5-hydroxytryptamine (5-HT) into the serosal fluid measured.2. 5-HT appeared in the serosal fluid from quiescent segments of rabbit intestine at a rate of about 4.0 ng/cm intestine/hr and about 14.0 ng/cm intestine/hr from segments performing active peristaltic movements.3. For both quiescent and active segments, when the perfusion fluid contained a monoamine oxidase inhibitor, nialamide (Niamid), the rate of appearance of 5-HT was increased and if, in addition, 5-HT was present in the perfusion fluid the rate of appearance of 5-HT in the serosal fluid was even greater.4. The rate of appearance of 5-HT from the intestine of rabbits pretreated with reserpine was about 0.8 ng/cm intestine/hr and Niamid only slightly increased this rate. However, if 5-HT as well as Niamid were present the rate of appearance of 5-HT was about 6.0 ng/cm intestine/hr.5. Possible explanations for these findings are discussed.


Observations on adaptation and defense in statu nascendi. Developmental precursors in the first two years of life.


The sense of femaleness.

The sense of femaleness.


The turn to mania.

The turn to mania.


The deceiving superego and the masochistic ego in mania.


Venous occlusion plethysmography in children. 1. Method.


Venous occlusion plethysmography in children. II. Resting calf blood flow in healthy children.


Hereditary fructose intolerance in four Swedish families.


Metachromatic leucodystrophy in early childhood. Treatment with a diet deficient in vitamin A.


The role of aldosterone in hypernatremic dehydration in infants.


Development of non-respiratory components of acid-base equilibrium in 250 normal children aged one month to 15 years.


A film about breast feeding in Sweden.

A film about breast feeding in Sweden.


Nonspherocytic haemolytic anaemia and severe jaundice in a newborn with partial pyruvate kinase deficiency.


Dermatoglyphs in congenital heart disease. A familial survey of 100 cases.


Chikungunya disease.

Chikungunya disease.


Isolation of Ilhéus virus from man in Colombia.


Nodamura virus, an ether- and chloroform-resistant arbovirus from Japan: physical and biological properties, with ecologic observations.


Growth of phlebotomus (sand fly) fever viruses in hamster-embryo tissue culture.


Duration of attack measures in a malaria-eradication program.


Distribution of paracoccidioidin sensitivity in Colombia.


A quantitative post-mortem study of Schistosomiasis mansoni in man.


The circumoval precipitin (COP) test in Schistosomiasis japonica.


Epidemiologic role of skin hypersensitivity in hookworm disease.


Blastomyces dermatitidis infection in the Congo. Report of a second autochthonous case.


Aortic stenosis in aged patients. Electroencephalographic trial.


Cerebral oedema as a consequence of experimental cervical lymphatic blockage.


Semi-chronic implantation of large cannulas in the aorta and right ventricle of white rats.


Variations in isolations of pathogenic bacteria from the udders of cows during a six-month period.


Light yields from soluble versus insoluble extracts of the bioluminescent marine dinoflagellate, Gonyaulax polyedra.


Some distinctive properties of pyruvate kinase purified from rat liver.


Photosensitized dimerization of pyrimidines.


The inhibition of photoreactions of chloroplasts by ioxynil.


Acetyl CoA level in perfused rat liver during gluconeogenesis and ketogenesis.


The submitochondrial distribution of the fatty acid oxidizing system in rat liver mitochondria.


Stimulation of the decarboxylation of S-adenosylmethionine by putrescine in mammalian tissues.


Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase.


Formation of insoluble gels and dityrosine by the action of peroxidase on soluble collagens.


A study of factors regulating RNA synthesis in HeLa cells using MPB, a reversible inhibitor of RNA synthesis.


The identification of isopeptide crosslinks in insoluble fibrin.


Recombination of mitochondrial drug-resistance factors in Saccharomyces cerevisiae.


Enzymic synthesis of cobinamide phosphate from cobinamide by extracts of Propionibacterium shermanii.


A study of polyanion-cation interactions using hydrated electrons.


An enzymatic factor from calf thymus causing hyperchromicity in DNA without strand scission.


The stability constants of the Fe3+ conalbumin complexes.


The effect of the selective reduction of yeast transfer ribonucleic acid with sodium borohydride on the acceptance of valine and serine.


Inhibition of protein synthesis and simulation of permease turnover in yeast.


Structural characterization of hemoglobin-N-Seattle.


Amino acid composition and peptide maps of beta-lactoglobulin variants.


The transition between 'acid' and 'alkaline' ferric heme proteins.


Circular dichroism of squid rhodopsin.

Circular dichroism of squid rhodopsin.


Spectral change of phycoerythrin from hydrocoleum species and its relationship to protein dissociation. Effect of mercurials on single- and double-peaked forms.


Specificity effects of cation binding to the macroion in the bovine serum albumin-histamine interaction.


Fibrinogen-fibrin interaction.

Fibrinogen-fibrin interaction.


The use of proteolytic enzymes in the study of ribosomal structure.


The relationship between soluble and insoluble protein in the lens.


Human pituitary growth hormone. XVI. Reduction with dithiothreitol in the absence of urea.


Control of purine biosynthesis de novo by orotic acid in vivo and in vitro.


Adenine nucleotide metabolism of blood platelets. II. Uptake of adenosine and inhibition of ADP-induced platelet aggregation.


Countercurrent distribution of RNA from rat liver: effect of growth hormone, thyroxine, and hydrocortisone on distribution patterns.


Nuclear magnetic resonance studies of complexes between caffeine and aromatic donors.


The synthesis of RNA by mammalian cells treated with the aminonucleoside of puromycin.


Stability of peptidyl-tRNA - the intermediate of protein synthesis.


Spectral properties of chymotrypsinogen-DNA complexes and the effects of heating.


Incorporation of radioactivity from monoiodotyrosine by soluble systems.


Degradation of histones during the manipulation of isolated nuclei and deoxyribonucleoprotein.


Further studies on the biosynthesis of very lysine-rich histones in isolated nuclei.


Sedimentation of rapidly labelled RNA from rat liver in different gradients.


Effect of methotrexate on pyrimidine metabolism in regenerating rat liver.


Modified procedure for the synthesis of 32P-labelled ribonucleoside 5'-monophosphates of high specific activity.


Protein synthetic activities of mycobacterial ribosomes in vivo.


The globins and their synthesis in the erythroid cells of the chick embryo.


Mode of action of neocarzinostatin: requirement of protein synthesis for neocarzinostatin-mediated DNA degradation in Sarcina lutea.


Intra-arterial barbiturates. A study of some factors leading to intravascular thrombosis.


Effects of inhalation anaesthetics on carotid body chemoreceptor activity.


Blood gas and electrolyte determinations during exposure to ultrasonic nebulized aerosols.


Accidental severe hypercapnia during anaesthesia.


Safe reversal. 2. Atropine-neostigmine mixture: an electrocardiographic study.


Accidental hypercapnia and rotameter bobbins.


Some aspects of general anaesthesia for cerebral angiography.


Clinical studies of induction agents. XXIV. The influence of anaesthesia with thiopentone and propanidid on the blood sugar level.


Carbon-dioxide elimination during closed chest cardiac massage. Case report.


Effect of propranolol on the ventricular arrhythmias induced by hpercarbia during halothane anaesthesia in man.


Evaluation of a respirometer for neonates.


A simple improvement in the EMO vaporizer.


A method of sterilization for the East-Radcliffe ventilator.


Perforation of the gall-bladder.

Perforation of the gall-bladder.


A histological examination of veins used in artificial arteriovenous ("Quinton/Scribner") shunts.


Embolectomy by ring disobliteration.

Embolectomy by ring disobliteration.


Blood-flow in deep veins of leg. Recording technique and evaluation of methods to increase flow during operation.


The clinicopathological correlation of high-pressure injection injuries.


Pelvirectal fistula treated by temporary colostomy.


Phlebography of the lower limb.

Phlebography of the lower limb.


The effect of small doses of heparin on platelet adhesiveness and lipoprotein-lipase activity before and after operation.


Primary tuberculosis of the stomach, caecum, and appendix treated with antituberculous drugs.


Hodgkin's disease involing the thyroid gland.


Early differentiation of motor neuroblasts in the chick embryo as studied by electron microscopy. II. Microtubules and neurofilaments.


The stimulation of liver growth and demethylase activity following phenobarbital treatment.


The ribosomes of encysted embryos of Artemia salina during cryptobiosis and resumption of development.


Development of neuronal specificity in retinal ganglion cells of Xenopus.


Cessation of DNA synthesis in retinal ganglion cells correlated with the time of specification of their central conections.


Acetylcholinesterase activity in the chick embryo spinal cords.


Protein starvation and the small intestine. I. The growth and morphology of the small intestine in weanling rats.


Crystalloid structures of hepatic mitochondria in children with heparitin sulphate mucopolysaccharidosis (Sanfilippo type).


The effect of postlathyritic medial scar on the progression of experimental atherosclerosis in rats.


Electron microscopy of isolated dog brain.


Effect of different frequencies of vibration on pain-threshold detection.


Interactions between extraocular myotatic and ascending vestibular activities.


Microelectrode studies of the afferent connections and efferent projections of neurons in the sensorimotor cortex of the cat.


Field potentials in the cat medial superior olivary nucleus.


Evidence that electroconvulsive shock alters memory retrieval rather than memory consolidation.


Effects of cross-reinnervation on some chemical properties of red and white muscles of rat and cat.


Response of cells to restricted visual stimuli in an association area of cat cerebral cortex.


Hippocampal epileptic activity induced by localized ventricular perfusion with high-potassium cerebrospinal fluid.


Activity levels in prosimians.

Activity levels in prosimians.


Baseline blood values of the chimpanzee. II. The relationship of age and sex and serum chemistry values.


Clinical laboratory proficiency testing.


Regulation of interstate clinical laboratories.


Factors determining the development of anaphylactic hypersensitivity in the guinea pig, and their influence on mechanisms involved in desensitization.


Inhibition of macrophage migration in vitro by brain and encephalitogenic factor in allergic encephalomyelitis.


Plasma growth hormone concentration in corticosteroid-treated children. Endogenous plasma growth hormone concentrations were measured in 23 children who were receiving daily corticosteroid therapy and in 10 control asthmatic children who had not received steroids for at least 8 months. The growth hormone concentrations were similar in the two groups of patients both during the fasting state and after insulin-induced hypoglycemia. 12 children, who were studied while receiving a large dose of prednisone and again 2 wk after steroid withdrawal, also showed no change in growth hormone concentration in relation to corticosteroid therapy. These findings suggest that deficiency of growth hormone is not the major mechanism responsible for the dwarfism of corticosteroid-treated children.


Kinetics of thrombopoiesis.

Kinetics of thrombopoiesis. Measurements of megakaryocyte number, volume, nuclear number, and cytoplasmic granulation were compared in animals with induced thrombocytosis, normal platelet counts, and induced thrombocytopenia for 4- and 10-day periods. Thrombopoiesis, as measured by megakaryocytic mass and (35)S incorporation into platelets, appeared to be regulated by the demand for circulating platelets. In addition, two mechanisms were operative in the alteration of thrombopoiesis. The first mechanism involved the regulation of endomitosis in the immature megakaryocytes which in turn determined the subsequent volume of platelet-producing cytoplasm. The second mechanism regulated the number of megakaryocytes formed from the precursor, "stem cell," compartment.


Age changes in five parameters of metacarpal growth.


Evaluation of a television image processing system.


Effect of dopamine on renal vasculature of dogs with experimental renovascular hypertension.


Metabolic effects of human growth hormone in corticosteroid-treated children. The effects of administered human growth hormone (HGH) were evaluated in dwarfed, prepubertal children who were receiving long-term corticosteroid therapy for a chronic disease. During 11 complete metabolic balance studies, the eight corticosteroid-treated children demonstrated impaired response to large doses of HGH with minimal nitrogen and no phosphorus retention. In contrast, two hypopituitary subjects and two asthmatic children not receiving corticosteroid responded to the same preparations of HGH with nitrogen, potassium, and phosphorus retention. Six corticosteroid-treated children were given large doses of HGH (40-120 mg/wk for 4 to 8 months and showed no improvement in their retarded rate of growth, whereas the hypopituitary subjects showed accelerated growth during administration of 10-15 mg of HGH/wk. It is concluded that dwarfism in steroid-treated children results from corticosteroid-induced antagonism of the effects of HGH at the peripheral tissue level.