Residual ethylene oxide and ethylene glycol in ethylene oxide sterilized pharmaceuticals.


Method for determining in vivo tablet disintegration.


Amino derivatives of thiophene isosteres of indanone and tetralone.


Automated technique for determining dissolution and reaction rates of antacids. II. Commercial antacid products.


Synthesis of 1,2-epoxyindans.

Synthesis of 1,2-epoxyindans.


Heidelberg capsule. I. In vitro evaluation of a new instrument for measuring intragastric pH.


Quantitative determination of pilocarpine in ophthalmic solutions.


Synthesis of carbamoylpiperidine-type cholinesterase inhibitors.


Antimicrobial properties of a propylene glycol based topical therapeutic agent.


Phytochemical and pharmacological investigation of Anemopsis californica.


2-Halogenoethylamines as potential folic acid antagonists. I. Synthesis and biological activity of ethyl-N-[1-(2-amino-4-hydroxy-6-methyl-5-pyrimidyl)-3-(2-chloro)-propyl]-p-aminobenzoate.


Dichloroacetaldehyde in the Mannich reaction.


Spectrophotometric determination of a mixture of secondary and tertiary amines in urine.


Recorded amperometric tetraphenylborate titrations of amines, quaternary nitrogen compounds, and potassium salts.


Preparation of 1,2,4-triazole derivatives of s-triazines.


Colorimetric method for the determination of 1,3-bis(2-chloroethyl)-1-nitrosourea.


Synthesis and configurational analysis of picolinaldehyde oximes.


Theoretical relationship between dose, elimination rate, and duration of pharmacologic effect of drugs.


Innovation out of unity.

Innovation out of unity.


Birth control in Lima, Peru: attitudes and practices.


The health profession and the changing community.


Cohort population redistribution and the urban hierarchy.


Medical care and conflict in Saskatchewan.


Tetanus; a nursing care study.

Tetanus; a nursing care study.


Prevention in psychiatry. 3. Psychiatric rehabilitation.


Wrightington Hospital--modern orthopaedics centre.


An intensive therapy chart.

An intensive therapy chart.


"Air call standing by".

"Air call standing by".


Patient care. 2. Patients and staff--their likes and dislikes.


Baby technician.

Baby technician.


Diagnosis of cardiac arrest: a non-nursing duty?


Integrating nursing service and mixing the sexes in a psychiatric hospital.


No personal consideration.

No personal consideration.


Midwifery and midwife training in Nigeria. At first, the task of persuading expectant mothers at Ile-Ife, Nigeria, of the need for antenatal care was hard going, but things began to change when the author and her sister attacked the problem from the baby clinic angle.  Mothers saw the results of prophylactic medications against malaria, vitamins, and immunization programs.  One mother, with a misshapen pelvis and a history of stillbirths, who delivered a living child after care at the clinic, became the best advertisement.  Thenceforth, the work grew fast.  In 1950, the clinic became a registered Grade 2 training school for midwives.  Soon after graduating 5 girls, who were all successful in taking the Nigeria Midwives Board examination, the clinic became a Grade 1 school for training midwives.  All nurses admitted to the course are already trained nurses.  From 300 mothers in the first year of operation, the clinic now cares for over 900, and this year will probably top 1000.


Outpatient treatment of the emotionally ill child: a comparison of two psychotropic agents.


A general concept of disease.

A general concept of disease.


How reliable are patients in judging anorectics?


Psycho-social factors in a family with a disfiguring genetic fault.


The adolescent patient in medical practice: social and emotional characteristics.


A clinical trial of protriptyline in childhood enuresis.


Lifelong obesity--a contribution to the understanding of recalcitrant obesity.


Drugs or psychotherapy.

Drugs or psychotherapy.


Bruxism as an emotional reactive disturbance.


Documentation of transient arrhythmias by constant cardiac monitoring.


Electrocardiocorder-AVSEP patterns in 37 normal adult men. A four year experience.


Auscultatory and phonocardiographic findings in patients with prosthetic ball-valves.


Double (mitral and tricuspid) opening snap in patients with valvular lesions.


The initiation of ventricular tachycardia and fibrillation in experimental coronary artery occlusion.


Functional mitral insufficiency in acute myocardial ischemia.


Current status of embolectomy for acute massive pulmonary embolism.


Effect of vasopressor drugs on circulatory dynamics in shock following myocardial infarction.


Vasodilator action of a "pressor amine," mephentermine (Wyamine), in circulatory shock.


Acute coronary occlusion as a cause of myocardial infarct and sudden coronary heart death.


Cardiology after the California gold rush (Wooster, 1867).


Paralytic ileus following myocardial infarction.


Traumatic calcific nonconstrictive pericarditis.


Electrocardiographic diagnosis of arrhythmias. An experiment in testing the physician's proficiency.


The flaming cell in multiple myeloma. A light and electron microscopy study.


Mesenteric insufficiency.

Mesenteric insufficiency.


Acute glomerulonephritis. a light and electron microscopy study of eight serial biopsies.


The nondistensible right atrium of carcinoid disease of the heart.


The so-called "juvenile aponeurotic fibroma".


Positive epinephrine skin test for "circulating endotoxin" in inflammatory disease of the intestine.


Penicillin antibody as a cause of positive direct antiglobulin tests.


The demonstration of fetal type hemoglobin by paper electrophoresis.


Standardization of platelets in the thromboplastin generation test.


A modification of the unopette to permit reuse.


Platelet counts with the Coulter counter.


Serology in a general hospital.

Serology in a general hospital.


Influence of lysozyme on the Treponema pallidum immobilization test performed by the Utrilla-Bravo technic.


Evaluation of serologic tests for syphilis in a state hygienic laboratory.


The effect of maintenance doses of digitalis on the rate of success of cardioversion.


The clinical and roentgen aspects of Ewing's sarcoma.


Classification of diabetic retinopathy: a guide to therapy.


The coexistence of myasthenia gravis and pernicious anemia.


Iatrogenic hypothyroidism in a patient with Turner's syndrome.


Venous cannulas for cardiopulmonary bypass.


Incisional drape for microsurgery.

Incisional drape for microsurgery.


A hemostatic clip.

A hemostatic clip.


Surgical education.

Surgical education.


Cholecystectomy for a "normal" gallbladder: is it ever justified?


A surgeon must review his mortality.

A surgeon must review his mortality.


Diagnosis and management of acute pancreatitis.


A four year reappraisal of hiatus hernia repair by intraperitoneal gastric fixation.


Fate of enzyme-digested bovine arterial heterografts in low pressure systems.


Spontaneous pneumothorax.

Spontaneous pneumothorax.


Siliconized Foley catheters.

Siliconized Foley catheters.


Lymphatic extension of carcinoma of the lung to the anterior chest wall.


Acute hypertension as a diagnostic clue in traumatic rupture of the thoracic aorta.


Neonatal gastric perforation.

Neonatal gastric perforation.


Duplication cysts of the gastrointestinal tract.


Huge retroperitoneal liposarcoma.

Huge retroperitoneal liposarcoma.


Idiopathic muscular hypertrophy of the intestinal tract.


Adenoma of Brunner's glands.

Adenoma of Brunner's glands.


Neonatal gastric perforation secondary to annular pancreas.


Choledochal cyst.

Choledochal cyst.


Single stage resection of three pheochromocytomas.


Absence of detrimental effect of the carrier state for the cystic fibrosis gene.


Effects of early comprehensive rehabilitation services in tuberculosis. An interagency experimental study.


Pulmonary tuberculosis and carcinoma of the lung. A survey from two population-based disease registers.


Expiratory air-flow pattern in tracheobronchial collapse.


Chronic diffuse pulmonary infiltration and airway obstruction.


Effect of posture on arterial-alveolar carbon dioxide gradient and physiologic dead space measurements.


Air embolism during pneumoperitoneum refill.


Performance of Olympic runners at altitudes of 7,350 and 5,350 feet.


Dyspnea and pulmonary function tests.

Dyspnea and pulmonary function tests.


From a medical Jeremiah.

From a medical Jeremiah.


Diving for fun.

Diving for fun.


The regulation of body temperature during fever.


Physiological factors in decompression sickness.


Biological effects of urban air pollution. II. Chronic exposure of guinea pigs.


Protection against inhalation of chromic acid mist. Use of filters impregnated with ascorbic acid.


Covert pathogenesis of NO2 induced emphysema in the rat.


Exposure to parathion. Dermal and inhalation exposure to parathion while spraying tomato bushes with a Knap-Sack Mister.


The meteorology associated with New Orleans asthma.


Tuberculin reaction trends and BCG vaccination. Special reference to young adults (medical students).


Urinary bladder calculi formed in rats at altitude.


Bladder tumors in a coal tar dye plant.

Bladder tumors in a coal tar dye plant.


Aerospace considerations in health and disease.


Emotional first aid.

Emotional first aid.


Behavioral aspects of public health.

Behavioral aspects of public health.


Vocational appraisal and disability evaluation.


Standards for exposure to airborne contaminants.


The metamorphosis of occupational medicine to environmental medicine.


Organic phosphate (phosdrin) intoxication. Report of a case and the results of treatment with 2-PAM.


Evaluating mental health factors in medical examinations for critical jobs in industry.


Effects of adenosine analogues and of heparin on platelet thrombi in non-lipaemic and lipaemic rats.


Studies on thyroid microsomal antigens.

Studies on thyroid microsomal antigens.


Fibrinolytic properties and electron microscopic features of rabbit ear chamber endothelium.


Cyanide, vitamin B-12, experimental demyelination and tobacco amblyopia.


Anticoagulants and experimental wound healing.


Isolation of a potent nephrotoxic serum antigen preparation from rat heart.


Penetration and irritation of the skin by Dermatophilus congolensis.


Telodrin, its synthesis and derivatives.


Reaction of nitrosyl fluoride with steroid 5-enes: a novel synthesis of 5-alpha-fluoro-6-oxo-steroids.


Abnormal arteriovenous communications. Great variability of effects with particular reference to delayed development of cardiac failure.


Anatomy of the coronary arteries in health and disease.


Palliative surgery in tricuspid atresia. Forty-two cases.


Ventricular septal aneurysms. A report of two cases.


Idiopathic enlargement of the right atrium.


The development of hypertension after rupture of a kidney.


Coronary artery-atrioventricular fistula and ventricular septal defect due to penetrating wound of the heart.


Managing a pediatric practice--some fundamental considerations.


Contribution to study of the skin innervation in certain laboratory animals. II. White rat and white mouse.


General methods of synthesis of indole alkaloids. V. Syntheses of d,l-corynantheidol and d,l-epialloyohimbane.


Determining the volume deviation in measuring.


Study of metal-ion binding to nucleic acids by 31-P nuclear magnetic resonance.


Nuclear magnetic resonance study of metal-ion binding to adenosine triphosphate. I. 31-P studies.


Nuclear magnetic resonance study of metal-ion binding to adenosine triphosphate. II. Proton studies.


Simplification as a strategy for research in psychotherapy.


An evaluation of the efficacy of brief-contact therapy with hospitalized psychiatric patients.


The usefulness of two scoring systems for the Bender Gestalt test for identifying brain damage.


Correlates of hypnotic susceptibility.

Correlates of hypnotic susceptibility.


The right drug for the right patient.

The right drug for the right patient.


A configurational analysis of children's reports of parent behavior.


College student personality correlates of early parent-child relationship.


A study of response to achromatic and chromatic stimuli.


The repression-sensitization scale as a measure of adjustment: relationship with the CPI.


Problems in living, psychotherapy process research, and in autoanalytic method.


Sexual bias in the WAIS.

Sexual bias in the WAIS.


Delinquents' perceptions of their parents.


The Bender Gestalt as a measure of intelligence and adjustment in the lower intellectual range.


Validation of the multiple affect adjective check list in clinical situations.


Intratest scatter in hospitalized brain-damaged and schizophrenic patients.


Group Rorschach technique for screening army officers.


Prediction of work potential in heart patients through use of the cardiac adjustment scale.


Lipids of connective tissue. I. The in vitro incorporation of acetate-1-C-14 into the neutral lipids of the carrageenin granuloma.


The mitomycin antibiotics. Synthetic studies. VI. Transformations in the 2,3-dihydro-1-H-pyrrolo[1,2-alpha]indole system.


The mitomycin antibiotics. Synthetic studies. V. Preparation of 7-methoxymitosene.


Steroids. CCLXXVI. The acid-catalyzed reaction between ketones and formaldehyde in dimethyl sulfoxide.


The mitomycin antibiotics. Synthetic studies. VII. An exploration of pyrrolo[1,2-alpha]indole A-ring chemistry directed toward the introduction of the aziridine function.


Nucleoside studies. IV. The synthesis of 2',5'-dideoxycytidines and other derivatives of 2'-deoxycytidine.


Potential antiradiation agents. Preparation and polymerization of S-vinyl-N-vinylthiocarbamates.


Steroids. CCLXXXI. Spectra and stereochemistry. XXI. Nuclear magnetic resonance spectra of methylated phenanthrenes.


Dismutation reactions of nucleoside polyphosphates. 3. The synthesis of alpha, omega-dinucleoside 5'-polyphosphates.


Cycloserine. 3. A Schiff base and its reactions.


The action of triphenylphosphine dibromide on sterol and bile acid derivatives.


Microbiological hydroxylation of saturated 17-keto steroids.


Abnormal products during isolation of isonicotinic acid hydrazide.


Lactols derived from steroidal 17a-oxa-D-homo lactones.


The synthesis of beta-amino mercaptans and beta-amino thiosulfates via ethylenimine intermediates.


Kinetics of hydrolysis of monothionsuccinimides.


Alpha,alpha'-diaminopimelic acid peptides. 8. Synthesis of symmetrical peptides containing meso-alpha,alpha'-diaminopimelic acid, D- or L-alanine, and L-glutamic acid.


Steroids. IV. A synthetic route to A-bisnorsteroids.


Retropinacol rearrangement of 1-alpha-hydroxy steroids. A new route to 1-beta-methyl 19-norsteroids.


Studies related to 2-keto steroids.

Studies related to 2-keto steroids.


Tumor inhibitors. X. Photochemical synthesis of phenanthrenes. Synthesis of aristolochic acid and related compounds.


Iodination of 2'-deoxycytidine and related substances. A reinvestigation of the structures of the by-product, C9H10I2N2O5, and its derivatives.


Buxus alkaloids. IX. The isolation and constitution of cyclobuxoxine.


Tumor inhibitors. IX. Synthesis of 10-nitro-1-phenanthroic acid.


Tumor inhibitors. XI. Proof of structure of aristolochic acid-C by total synthesis of its methyl ester methyl ether.


Quinazolines and 1,4-benzodiazepines. XXVI. 1,2-Dihydroquinazoline 3-oxides.


Chloromethylation of estrone methyl ether.


Synthetic nucleosides. LXV. Studies on the synthesis of cis-2,3-diamino sugars. V. Neighboring group reactions with derivatives of methyl 2-amino-4,6-O-benzylidene-2-deoxy-alpha-D-altropyranoside.


Synthetic nucleosides. LXVI. Studies on the synthesis of cis-2,3-diamino sugars. VI. Neighboring group reactions with methyl 4,6-O-Benzylidene-3-deoxy-2-O-methanesulfonyl-3-thioureido-alpha-D-glucopyranoside.


Synthetic nucleosides. LXVII. Studies on the synthesis of  cis-2,3-diamino sugars. VII. Synthesis and reactions of some N-p-tolylsulfonyl derivatives  of 2-amino-2-deoxy-D-altrose, 3-amino-3-deoxy-D-glucose, and 2,3-dideoxy-2,3imino-D-mannose.


Synthetic nucleosides. 68. Studies on the synthesis of cis-2,3-diamino sugars. 8. Derivatives of 2,3-diamino-2,3-dideoxy-D-ribose and 2,3-dideoxy-2,3-imino-D-ribose.


Steroids. CCLXXXII. Some reactions of 5-beta-,19-cyclo 6-oxgenated steroids in acid media.


Studies on terpenes. 3. The synthesis of dl-12-oxo-6,9-ethano-cis-delta-1,2-octalin, a potentially useful intermediate for the total synthesis of the diterpene alkaloid, atisine.


Steroids. CCLXXXIV. Reactions of 19-hydroxy-delta-5-3-acetoxy steroids with diethyl(2-chloro-1,1,2-trifluoroethyl) amine.


Studies directed toward the synthesis of plasmalogens. II. (+ or-)-Cis- and -trans-3-(n-hexadec-1'-enyloxy)-1,2-propanediol.


Microbiological hydroxylation of alkaloids from Funtumia latifolia.


The structure of senegenic acid, a nortriterpene artifact from Polygala senega.


The mitomycin antibiotics. Synthetic studies. 8. Nitration and O-benzyl rearrangement in the 7-oxypyrroloindole system.


Nucleosides. II. Reactions of 5'-trityluridine 2',3'-O-thionocarbonate.


Penicillin sulfoxides.

Penicillin sulfoxides.


Significance of the history in the diagnosis of traumatic injury to children. Howland Award Address.


A broad horizon.

A broad horizon.


The immediate and long-term physiologic function of bilateral reimplanted lungs.


An artificial heart inside the chest.

An artificial heart inside the chest.


The permanently implanted bypass heart.

The permanently implanted bypass heart.


The normal mode of action of the mitral valve and its alteration following replacement by a prosthetic ball valve.


Assisted circulation: the pressure pulse generator.


Factors limiting survival after circulatory occlusion under hypothermia and hyperbaric oxygenation.


Open-heart surgery for mitral valve disease, with special reference to a new prosthetic valve.


The influence of hyperbaric oxygen and of hypoxia on the ventricular fibrillation threshold.


Clinical experience and problems encountered with an implantable pacemaker.


A new rechargeable epicardial cardiac pacemaker.


Prophylactic antibiotics in thoracic surgery; an experimental evaluation.


Digitalis and thoracic surgery.

Digitalis and thoracic surgery.


Effect of low molecular weight dextran, heparin, urea, cerebrospinal fluid drainage, and hypothermia on ischemic injury of the spinal cord secondary to mobilization of the thoracic aorta from the posterior parietes.


Antibiotics and cardiac surgery.

Antibiotics and cardiac surgery.


The effect of intermittent and prolonged renal artery occlusion upon respiration and anaerobic glycolysis of dog kidney.


Diphallia: report of a case.

Diphallia: report of a case.


Urethral hemangioma.

Urethral hemangioma.


Pure testicular rhabdomyosarcoma.

Pure testicular rhabdomyosarcoma.


The AZ titer as an aid in the treatment of testicular tumors.


Transposition of the external genitalia.


Unusual complication of transurethral prostatic resection.


The effect of roentgen ray treatment of gynecomastia in patients with prostatic carcinoma treated with estrogenic hormones: a preliminary communication.


Retroperitoneal hypernephroid mesonephroma.


The value of the prone roentgenogram during excretory urography.


Foley catheter retained for 3 years.

Foley catheter retained for 3 years.


Facial disfigurement--a plea for safety belts.


Rehabilitation and re-employment of the tuberculous patient.


Methylated-spirit drinking in male prisioners.


A study of in-patients with psychiatric problems in a Tasmanian general hospital.


Iatrogenic alkalosis in childhood.

Iatrogenic alkalosis in childhood.


Laryngeal complications of prolonged endotracheal intubation.


A case of Peutz-Jeghers syndrome presenting with recurrent intussusception.


Strangulated appendix epiploica presenting per vaginam.


The national health picture.

The national health picture.


Recent advances in ambulance transport nursing in South Australia.


Problems facing the doctor in a changing world.


Thermal comfort in Antarctica.

Thermal comfort in Antarctica.


Cigarette smoking in Melbourne. I.

Cigarette smoking in Melbourne. I.


Biliary tract emergencies.

Biliary tract emergencies.


Settling the requirements of man for protein.


Phenindione therapy and haematuria.

Phenindione therapy and haematuria.


Effect of splenectomy on bone marrow cellularity in the dog.


Utilization of inorganic radioselenium for biosynthetic labeling of "tracer" proteins.


Contact lens questionnaire report.

Contact lens questionnaire report.


Medical research and the silicones.

Medical research and the silicones.


Ventricular tachycardia after experimental myocardial infarction: effects of adrenergic amines and increased aortic pressure.


The esthetic-plastic profile.

The esthetic-plastic profile.


Present day management of sinus disease.


Mistakes in refraction.

Mistakes in refraction.


Leukoerythroblastosis in the adult.

Leukoerythroblastosis in the adult.


A hematology control chart.

A hematology control chart.


A data processing system for hematology.


A new bone marrow finding characteristic of incompatible blood transfusion.


Application of atomic absorption spectrophotometry in the determination of iron in urine.


The assay of glutethimide.

The assay of glutethimide.


BSSA: an agglutinogen for quantitation of antistreptolysin O.


Dissolving membrane filters in detecting malignant cells in circulating blood.


Barium sulfate and zinc sulfide deposits resulting from golf-ball injury to the conjunctiva and eyelid.


Pulmonary alveolar proteinosis. Histochemical observations.


Right transaxillary thoracic aortography in the diagnosis of dissecting aneurysm.


Lymphangiographic evaluation of lymphedema and lymphatic flow.


Radiology and the American Medical Association.


The veins of the posterior fossa--superior or galenic draining group.


Tentorial branches of the internal carotid artery.


Retrograde aortography. A screening method for cerebral vascular insufficiency.


The relation of arterial trauma to complications of cerebral angiography.


Myelitis simulating spinal cord tumor.

Myelitis simulating spinal cord tumor.


The comparison of the complication rates of meglumine iothalamate and sodium diatrizoate in cerebral angiography.


Myelographic findings in hypertrophic interstitial neuritis.


A study of roentgenologic criteria for rheumatoid arthritis of the cervical spine.


A simple transducer for the recording of the volume and duration of injection during angiography.


A device for the measurement of pressure and injection time of contrast substance through catheters.


Linear laminagraphy. A simple geometric interpretation of its clinical limitations.


Electric shock hazards in radiology departments.


Histopathology of the development of the axial skeleton and spinal cord in the irradiated tail of the young axolotl (Siredon mexicanum).


Sociology of yesterday, today and tomorrow.


The cohort as a concept in the study of social change.


Becoming a world-saver: a theory of conversion to a deviant perspective.


Durkheim's one cause of suicide.

Durkheim's one cause of suicide.


The precipitants and underlying conditions of race riots.


Urban crime patterns.

Urban crime patterns.


A note on self-concept as an insulator against delinquency.


Angioma serpiginosum, a comparative study.


Cutaneous vascular reactivity in atopic children.


How often does squamous cell carcinoma of the skin metastasize?


Dermopathy in the diabetic syndrome.

Dermopathy in the diabetic syndrome.


Idiopathic atrophoderma.

Idiopathic atrophoderma.


Xeroderma pigmentosum.

Xeroderma pigmentosum.


Pseudosarcomatous fibromatosis (fasciitis).


Keratoacanthoma dyskeratoticum and segregans.


Erythema multiforme bullosum associated with Trichomonas infection.


A legacy of syphilis.

A legacy of syphilis.


Temporary x-ray epilation therapy of chronic axillary hidradenitis suppurativa.


Intralesional injection of triamcinolone in the treatment of cheilitis granulomatosa.


Localized argyria. II. Chemical nature of the silver containing particles.


Ultraviolet erythema.

Ultraviolet erythema.


Paronychia and onycholysis, etiology and therapy.


Why a symposium on acid-base balance?

Why a symposium on acid-base balance?


pH measurements.

pH measurements.


Some practical aspects of the measurement of acid-base balance in blood.


The chemistry of buffers.

The chemistry of buffers.


Blood and tissue buffers.

Blood and tissue buffers.


Acid-base problems in hypothermia.

Acid-base problems in hypothermia.


Osmolality.

Osmolality.


The effect of caffeine on free fatty acids.


Congenital aneurysm of the membranous ventricular septum.


Bone marrow failure in hypertrophic osteoarthropathy.


Painter's bosses.

Painter's bosses.


Retrograde activation of atria in auriculoventricular block. An electrocardiographic demonstration.


Corticosteroids, glaucoma, and time.

Corticosteroids, glaucoma, and time.


Glaucoma and corticosteroid provocative testing.


Blood transketolase levels in tobacco-alcohol amblyopia.


Alternating exophthalmos with painful ophthalmoplegia.


Tobacco-alcohol amblyopia. Further comments on its pathology.


Transilluminating diathermy applicator for retinal detachment surgery.


Clinicopathological correlation of retinal lesions. Subacute bacterial endocarditis.


Scleral abscess. II. The experimental production in animals.


Nonsurgical removal of corneal rust stains.


In defense of the art of medicine.

In defense of the art of medicine.


Oxygen flux across the in vivo rabbit cornea.


Arterialized in situ saphenous vein.

Arterialized in situ saphenous vein.


Long-term patency of solid-wall vascular prostheses.


Revascularization of upper extremity with autogenous vein bypass graft.


Proximal endarterectomy, arterial reconstruction for coronary occlusion at aortic origin.


Regional blood flow distribution with whole-body perfusion.


Regional blood flow during pulsatile and nonpulsatile perfusion.


Decreased risk of aortic valve surgery.

Decreased risk of aortic valve surgery.


Prosthetic left ventricle for continuous pressure assistance.


Rechargeable pacemaker for direct myocardial implantation.


Prevention of wound hemorrhage and embolism during heparin therapy.


Congenital diaphragmatic hernia through foramen of Bochdalek.


Ischemic stenosis of small intestine.

Ischemic stenosis of small intestine.


Pneumoperitoneum as aid for second stage repair of omphalocele.


Mesenteric panniculitis.

Mesenteric panniculitis.


Intra-arterial chemotherapy for cancer metastatic to liver.


Duplication of small intestine with perforated peptic ulcer in ectopic gastric mucosa.


Paired electrical stimulation of the heart: a physiologic riddle and a clinical challenge.


Hypertension and unilateral renal disease. The usefulness of modified intravenous urography.


Report of President's Commission on Heart Disease, Cancer, and Stroke.


Atrial reciprocal rhythm.

Atrial reciprocal rhythm.


Sudden, severe aortic insufficiency.

Sudden, severe aortic insufficiency.


Long-term postoperative follow-up in surgery for congenital aortic valvular stenosis.


Hemodynamic findings following replacement of the mitral valve with the University of Cape Town prosthesis.


The electrocardiogram after mastectomy.

The electrocardiogram after mastectomy.


Removal of iatrogenic foreign bodies within cardiac chambers and great vessels.


The role of hydrogen ion concentration in the regulation of pulmonary arterial pressure. Observations in a patient with hypoventilation and obesity.


The origin of an immediate diastolic murmur in atrioventricular defects.


Impaction of cardiac catheter in coronary vein.


Origin of both great vessels from the right ventricle associated with the trisomy-18 syndrome.


Fatal cerebral embolism complicating transseptal left heart catheterization.


Clinical recognition and treatment of primary myocardial disease. Introduction.


Primary myocardial disease.

Primary myocardial disease.


The language handicapped child and education.


Emotionally disturbed and brain damaged children--should we mix them?


A comparison of auditory amplifiers for the deaf.


The effect of a conjugated bile salt on oleic acid absorption in the rat.


Study of patients with lower esophageal ring by simultaneous cineradiography and manometry.


Forced diuresis in the management of barbiturate intoxication.


Anal sphincter abnormalities characteristic of myotonic dystrophy.


Portal systemic venous shunt. Pathological factors contributing to postoperative survival.


The autologous leukocyte skin test in patients with ulcerative colitis.


The reversal of hemochromatotic cirrhosis by multiple phlebotomies. Report of a case.


"Histamine-induced" pancreatitis.

"Histamine-induced" pancreatitis.


Desensitization, suggestibility, and pseudotherapy.


Hypertension and renal artery stenosis: seral observations on 54 patients treated medically.


Composite index of the Kent-Rosanoff free association test.


Impairment of knowledge of unusual meanings of familiar words in brain damage and schizophrenia.


Differential effects of social reward and punishment on dependent and dependency-anxious schizophrenics.


Increased sensitivity of the heart to catecholamine-induced arrhythmias following guanethidine.


Meaning dimensions and male-female voice perception in schizophrenics with good and poor premorbid adjustment.


The "induction" of leukocyte and erythrocyte dihydrofolate reductase by methotrexate. II. Clinical and pharmacologic studies.


Anticipation interval and age differences in verbal learning.


Temporal gradient of fear arousal in psychopaths.


Associative disturbance as a function of chronicity in schizophrenia.


Effects of weight intensity on discrimination thresholds of normals and schizophrenics.


Some effects of LSD-25 on verbal communication.


Anxiety level and the "doubtful" judgment in a psychophysical experiment.


Relationship of anxiety (drive) and response competition in problem solving.


Interpersonal types among psychiatric patients.


Biosynthesis of nicotine in Nicotiana glutinosa from carbon-14 dioxide. Labeling pattern in the pyrrolidine ring.


Evaluation of the dial-a-dietitian program. I.


Evaluation of the dial-a-dietitian program. II.


Epidemiology of coronary heart disease in Middlesex County, Connecticut.


Fat metabolism in pre-adolescent children on all-vegetable diets.


Content and stability of ascorbic acid in fruit drinks.


A yeast-leavened, low-protein bread for research diets.


Calcaneal apophysitis: a clinical and roentgenologic study.


Stress fracture of the talus.

Stress fracture of the talus.


Stimulus change and habituation of the orienting response.


The B-GSR module: a combined recording to present base skin resistance and galvanic skin reflex activity patterns.


Neural timing mechanisms, conditioning, and the CS-UCS interval.


An automatic analyzer of states of vigilance.


Electroencephalographic pattern quantification and the arousal continuum.


EEG electrodes for in-flight monitoring.


An inexpensive transducer for remote determination of arterial blood pressure.


An inexpensive masking noise generator: monaural or stereo.


A simplified method of heart rate measurement.


Practical guide and dietary management of children with seizures using the ketogenic diet.


Effect of supplementing the diet of man with tocopherol on the tocopherol levels of adipose tissue and plasma.


Plasma tocopherol levels in man.

Plasma tocopherol levels in man.


Relationship between free and total cholesterol values in human serum.


Epidemiologic study of hypertension. Comparative results of hypertensive surveys in two areas in northern Japan.


Intestinal lesions associated with triparanol. A clinical and experimental study.


Intestinal fat and iron transport, goblet cell mucus secretion, and cellular changes in protein deficiency observed with the electron microscope.


How effective are antacids?

How effective are antacids?


Evaluation of diazepam for pre-endoscopy medication.


The biphasic gastric secretory response in man.


Plasma protein clearance by the gut. A method of studying the exudative gastroenteropathies.


Adrenal function and plasma insulin activity in poorly regulated diabetics.


Peptic ulcer disease and temperature changes in Hawaii.


Dynamics of the Starr-Edwards ball valve prosthesis: a cine-fluorographic and ultrasonic study in humans.


Clinical use of a new glycine-precipitated antihemophilic fraction.


The use of alum precipitated pyridine pollen extract in the treatment of ragweed pollinosis.


Cytotoxicity of carbon tetrachloride as measured by loss of cellular enzymes to surrounding medium.


The effect of prior vitamin B-12 administration on the Schilling test.


The challenge to medical education.

The challenge to medical education.


The sex chromosomes of man.

The sex chromosomes of man.


Investigation of viral etiology for cervical cancer.


Influence of the pregnant uterus upon the rejection of adult homografts; a preliminary study.


Intra-amniotic injection of saline for therapeutic abortion.


The first five years of contraceptive service in a municipal hospital. September 17, 1958, the New York City Board of Hospitals ended an unwritten ban on contraception in municipal hospitals.  A week after these regulations were issued a contraceptive clinic was set up.  Although the clinic was prohibited from delivering services for nonmedical reasons and written consent from the patient, who was to be advised to consult with her spiritual advisor beforehand, was required, the clinic patients increased in numbers every year in the first 5 years of operation.  Patients were attracted to the clinic and to the hospital's Postpartum Clinic as well.  Advice in pregnancy prevention benefited the public.  The clinic provided a good training opportunity in contraception for medical students and practitioners on a national and international scale.  The facilities and records of the clinic were used for research purposes.  Studies were completed on the mode of action of the cervical cap, and on oral contraception.  Almost 5000 patients have attended the Bellevue Clinic during the first 5 years.  The total number of visits to the facility amounted to 18,000.


Growth patterns of cervical cancer without an intraepithelial stage, so-called monophasic growth; colposcopy studies.


The fine structure of the bacterial cell and the possibility of its artificial synthesis.


Quantitative estimation of p-hydroxyphenylpyruvic acid in human urine.


Direct radiochemical determination of lead-210 in bone.


Radiochemical determination of lead-210 in mill products and biological materials.


An x-ray fluorescence method for the determination of calcium, potassium, chlorine, sulfur, and phosphorus in biological tissues.


Fluorometric system employing immobilized cholinesterase for assaying anticholinesterase compounds.


Separation of glutamine and asparagine by ion exchange chromatography with temperature programming.


Resistance to airflow through the nose.

Resistance to airflow through the nose.


Primary malignant melanoma of the nasal fossa.


The blood vessels and pigmentary cells of the inner ear.


A study of the relative concentrations of antibiotics in the blood, spinal fluid, and perilymph in animals.


Directional preponderance and unilateral weakness as observed in the electronystagmographic examination.


The level of the larynx during childhood.


Congenital cholesteatoma of the middle ear and mastoid.


Articular reflex mechanisms in the larynx.


Osteoplastic frontal sinus operation: coronal incision.


Histologic changes in the trachea following tracheostomy.


Obliteration of the frontal sinus.

Obliteration of the frontal sinus.


Rhinological methods for controlling nasal polyposis and vasomotor rhinitis.


Teflon injection in the correction of velopharyngeal insufficiency.


Lipoma of the epiglottis and lipoma of the hypopharynx in the same patient.


Nerve grafting to restore function of the trapezius muscle after radical neck dissection. (A preliminary report).


Effect of dibenzyline treatment on cardiac dynamics and oxidative metabolism in hemorrhagic shock.


Vitreous contraction in proliferative diabetic retinopathy.


Fabry's disease. Its ocular manifestations.


Stimulation of a filtering bleb.

Stimulation of a filtering bleb.


Edema of posterior pole after cataract extraction. A biomicroscopic study.


Disposable cryophake--clinical evaluation.


An orbital metastasis from the urinary bladder.


Squamous cell carcinoma of cornea.

Squamous cell carcinoma of cornea.


Technique of semipenetrating cyclodiathermy puncture.


Rubber silicone injections.

Rubber silicone injections.


The finer structure of the auditory ossicles in otosclerosis.


Otosclerotic focus and facial canal.

Otosclerotic focus and facial canal.


Functional mechanism of the labyrinthine epithelium. II. Author's theory.


Percutaneous recording of cochlear microphonics in cats.


Surgery and pathology of Bell's palsy.

Surgery and pathology of Bell's palsy.


Reconstruction of ossicular chain in incus defects. An experimental study.


Middle ear pressure variations during anesthesia.


Protecting residual hearing in hearing aid user.


Middle ear mycosis in a premature infant. Clinicopathologic study of a case.


Long-term industrial hearing conservation results.


Carcinoma of the nasopharynx. Experiences with 66 patients.


Squamous cell carcinoma of Wharton's duct. A case of long-standing calculus.


Plasmacytoma of the parotid gland.

Plasmacytoma of the parotid gland.


Blow-out fracture of the orbital floor.

Blow-out fracture of the orbital floor.


Bilateral tuberculous granulomas of the tongue.


The effect of experimental haemorrhage on the levels of haemoglobin, plasma iron and tital iron-binding capacity in dairy calves.


Isolation and properties of glutamine cyclotransferase of dried papaya latex.


Division of synchronized Tetrahymena pyriformis after emacronucleation.


Masking-level differences as a function of interaural disparities in intensity of signal and of noise.


Learning to identify complex sounds: prompting versus confirmation.


Release from masking for speech.

Release from masking for speech.


Effect of filter type on energy-detection models for auditory signal detection.


Evaluation of new couplers for circumaural earphones.


The ontogeny of racial prejudice.

The ontogeny of racial prejudice.


Synthesis and biodegradability of isomeric sodium p-(thia-n-dodecyl)-benzenesulfonates.


Observation or participation: the problem of psychiatric research on social issues.


Schizophrenia in a patient with a defect in methionine metabolism.


Addiction Research Center Inventory (ARCI): development of a general drug estimation scale.


Litter patterns in the offspring of nervous and stable dogs. I. Behavioral tests.


Resolution of intrafamilial role conflict in families of schizophrenic patients. I. Thought disturbance.


The communicative value of parental speech in families with disturbed children.


Eye movements during emergent stage 1 EEG in subjects with lifelong blindness.


The use of combined schlieren and absorption optics in an electrophoretic study of the reversibly interacting system dextran sulfate--carboxyhemoglobin.


Dielectric dispersion of crystalline powders of amino acids, peptides, and proteins.


Is psychiatric hospitalization obsolete?


Some economic aspects of advanced waste treatment.


Report on hepatitis. Safety Committee--California Water Pollution Control Association.


Polymer-aided sludge elutriation and filtration.


Municipal waste ordinances--the views of industry.


Quality changes as a function of detention time in wastewater stabilization ponds.


Development of refinery wastewater control at Pascagoula, Mississippi.


Bio-oxidation kinetics and a second-order equation describing the bod reaction.


Textile waste treatment at Canton cotton mills.


Effect of temperature on the deoxygenation of a polluted estuary.


Correction for chloride interference in the chemical oxygen demand test.


How to get a mandatory certification bill through your legislature in six very difficult lessons.


The effect of nitrogen-to-carbon ratio on anaerobic decomposition.


Formulation and testing of a compartmental model for calcium metabolism in man.


The range of protons in human skullbone.


Irradiation of estrone and derivatives in acetic acid.


Radiation inactivation of potato phosphorylase.


Development of intestinal damage after x-irradiation and H3-thymidine incorporation into intestinal epithelial cells of irradiated goldfish, Carassius auratus, at different temperatures.


Alterations in muscle activity during gamma-irradiation.


Enzyme activity changes and cell volume distribution in mouse thymus after x-irradiation.


Dose-dependent effects of H3TDR as a DNA label on the replication of liver cells in the growing rat.


The effects of ionizing radiation on growth and regeneration of intrarenal thymus grafts in mice.


A note on the reponse of an extract from a medically used polyvinyl chloride tubing.


Acetylene compounds of potential pharmacological value. V. 5-(3-Dialkylamino-1-propynyl) derivatives of 5-hydroxy-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and related compounds.


Hydrolysis of barbituric acids. I. Rate studies on the hydrolysis of ions of some 1-methyl-5,5-disubstituted barbituric acids.


Hydrolysis of barbituric acids. 2. Rate studies on the hydrolysis of the ions of some 1,5-dimethyl-5-substituted and some 1-methyl-5,5-disubstituted barbituric acids.


Erythrophleguine, a new alkaloid from the bark of Erythrophleum guineense (G. Don).


Kwashiorkor and marasmus. Blood sugar levels and response to epinephrine.


Lower urinary tract obstruction in normal male children. Early detection by urinary diary.


Picture of the month.

Picture of the month.


Subependymal cerebral hemorrhage in infancy.


Radiological case of the month.

Radiological case of the month.


Aorta surgery in a child with Marfan's syndrome.


Congenital asymmetry associated with trisomy 18 mosaicism.


Congenital laryngeal cleft: report of a case. A comparison with other types of tracheo-esophageal communication.


Melkersson's syndrome. A case report of multiple recurrences of Bell's palsy and episodic facial edema.


Heterotopic duodenal mucosa in the stomach.


Psychiatry, the university, and the community.


Adrenogenital syndrome. Association with 3-beta-hydroxysteroid dehydrogenase deficiency.


Transcultural psychiatry.

Transcultural psychiatry.


New directions in mental health planning.


Social class and mental illness in children. Choice of treatment.


Peer group influences on the choice of a psychiatric viewpoint.


Relevance of psychotic patients' "insight" to their prognosis.


Consulting with aide-therapists. A revised role for the mental hospital psychiatrist.


Acting out.

Acting out.


Body composition of schizophrenics.

Body composition of schizophrenics.


The "break-off" phenomenon. A precipitant of anxiety in jet aviators.


Measuring disordered styles of thinking. Using the Object Sorting Test on parents of schizophrenic patients.


Facial defects: a mathematical survey of their incidence in Mexico.


Dupuytren's contracture in women.

Dupuytren's contracture in women.


Treatment of fractured mandibular condylar processes in children.


A method of local anaesthesia for the correction of simple fracture of the nose.


Injury to the ligaments of the ankle.

Injury to the ligaments of the ankle.


Idiopathic necrosis of the femoral head in adults.


The treatment of displaced fractures at the ankle by rigid internal fixation and early joint movement.


Treatment of ruptures of the lateral ligament of the ankle.


Instability of the foot after injuries to the lateral ligament of the ankle.


The etiology and prevention of functional instability of the foot.


Tendon injuries around the ankle.

Tendon injuries around the ankle.


A new method of hip fusion using an intramedullary nail. A preliminary report.


Arthrodesis of the hip by central dislocation and ilio-femoral nailing. A preliminary report.


Giant-cell tumours and aneurysmal bone cysts of the spine. With special reference to the problems related to the removal of a vertebral body.


Simple cysts of the humerus treated by radical excision.


The treatment of malunited anterior Monteggia fractures in children.


Smith's and Barton's fractures. A method of treatment.


Stress fractures of the femoral neck.

Stress fractures of the femoral neck.


Actinomycosis of a metacarpal bone. Report of a case.


Rigid valgus foot from fibrous contracture of the peronei.


Expanded polystyrene foam as a substitute for plaster of Paris for spinal shells.


Osteochondroma of the foot. Report of a case.


A histological study of avascular necrosis of the femoral head after transcervical fracture.


The histological appearances of late segmental collapse of the femoral head after transcervical fracture.


Dislocation of the hip in young rats produced experimentally by prolonged extension.


A continuous monitored dialysis-perfusion system for biologic application.


Manganese and copper levels in human urine.


Simultaneous use of two radioisotopes by scanner plus analogue computer coupling.


Dextran infusions and extracellular volume.


Letter to editor: radioisotope brain scanning.


Letter to the editor: bromomercurihydroxypropane for spleen localization.


Mechanical and electrical responses of single innervated crab-muscle fibres.


Physiology and pharmacology of the splanchnic-adrenal medullary junction.


Coronary flow rate and perfusion pressure as determinants of mechanical function and oxidative metabolism of isolated perfused rat heart.


Action of aldosterone and vasopressin on the active transport of sodium by the isolated toad bladder.


The relation between intrinsic speed of shortening and duration of the active state of muscle.


The mechanics of human smooth pursuit eye movement.


Electroreceptor mechanisms: the relation of impulse frequency to stimulus strength and responses to pulsed stimuli in the ampullae of Lorenzini of elasmobranchs.


Electrical behaviour of the motoneurone membrane during intracellularly applied current steps.


Water, and salt and water: a distinction should be made.


Bone growth and metabolic studies of premature infants treated with human growth hormone.


The plasma free fatty acid composition and blood glucose of normal and diabetic pregnant women and of their newborns.


Urinary excretion of citric acid cycle metabolites in premature newborn infants with and without a respiratory distress syndrome.


Comparison of methods for recording respiration in newborn infants.


Survival time of circulating long-acting thyroid stimulator in neonatal thyrotoxicosis: implications for diagnosis and therapy of the disorder.


A new type of idiopathic hyperglycinemia with hypo-oxaluria.


Male pseudohermaphroditism with female chromosomal constitution.


Renal tubular acidosis. Effects of sodium phosphate and sulfate on renal acidification in two patients with renal tubular acidosis.


Comparison of the tolerances of anesthetized adult dogs and pups to KCl infusion.


Quantitative assay of disaccharidase activities of small intestinal mucosal biopsy specimens in infancy and childhood.


Prevalence of mental retardation in a pediatric outpatient clinic population.


Diagnosis and treatment: group A streptococcal infections.


Annual summary of vital statistics--1964.


School health services.

School health services.


Septicemia due to group B streptococcus: report of two siblings presenting with lesions resembling erythema nodosum.


The pediatrician and Indian Health.

The pediatrician and Indian Health.


Radiologic diagnosis of primary and metastatic cancer in infants and children.


Mammography: some remarks on techniques.


Medical thermography: a summary of current status.


Lymphangiographic interpretation.

Lymphangiographic interpretation.


A brief atlas of diagnostic ultrasonic radiologic results.


Prevention of complications during vascular opacification studies.


A probabilistic approach to the diagnosis of bone tumors.


The radioactive strontium photoscan as a diagnostic aid in primary and metastatic cancer in bone.


Angiographic evaluation of lung neoplasms.


Retroperitoneal tumors: a survey and assessment of roentgen techniques.


Fatty acid composition of the small bowel mucosa in man.


Quantitative effects of dietary fat on serum cholesterol in man.


Influence of the nature of the fat in diets high in carbohydrate (mainly derived from bread) on the serum cholesterol.


The effects of test doses of leucine, isoleucine or valine on plasma amino acid levels. The unique effect of leucine.


Iron metabolism in premature infants. 3. Utilization of iron as related to growth in infants with low birth weight.


Cardiovascular responses in prolonged hypothermia.


Determinants of atrial contractile force in the intact heart.


Effect of extracellular pH on function and metabolism of isolated perfused rat heart.


Orthopedic aspects of hemophilia.

Orthopedic aspects of hemophilia.


Axial drift of cells and partial plasma skimming in blood flowing through glass slits.


Mechanism of reactive hyperemia in limbs of anesthetized dogs.


Effect of lactic acid on free fatty acids and glucose oxidation in dogs.


Training and bradycardia in rats.

Training and bradycardia in rats.


Role of reflexes following myocardial necrobiosis.


Role of calcium ions and phospholipids in platelet aggregation and plug formation.


Effect of insulin on potassium and glucose movement in perfused rat liver.


Correlation of motility and gas collection from goat rumen.


Effect of adrenalectomy on serum and tissue amylase.


Rhythmic changes in renal function in the rat.


Effects of acute acid-base changes on renal hemodynamics in anesthetized dogs.


Lactate concentration in the medulla of rat kidney.


Renal tubular transport of water, solute, and PAH in rats loaded with isotonic saline.


Potassium exchange between cerebrospinal fluid, plasma, and brain.


Kinetics of ammonia production and excretion in the acidotic dog.


Intracellular pH and intracellular buffering power of the cat brain.


Normal and myotonic goats receiving diazacholesterol.


Secretion of urea and thiourea in sweat.


Relationship of current parameters to hyperpnea produced by brain polarization.


Electrical transmission of slow waves from longitudinal to circular intestinal muscle.


Effects of cerebellar lesions and stimulation on the shivering tremor.


Central neural regulation of carotid baroreceptor reflexes in the cat.


Summation of bilateral carotid sinus signals in the barostatic reflex.


Adrenergic mechanisms in the bullfrog and turtle.


Salicylate: effects on ion transport and afterpotentials in frog sciatic nerve.


Membrane potentials of salivary gland cells of rat.


Ion transport in isolated cornea of the rabbit.


Squamous carcinoma in situ of the uterine cervix. I. Classification and histogenesis.


Squamous carcinoma in situ of the uterine cervix. II. Topography and clinical correlations.


Ideopathic lowering of the cortisol binding capacity of human plasma transcortin.


Reversible inactivation and dissociation of yeast hexokinase.


Isolation and identification of N-acetyl-3-amino-3,6-dideoxy-D-galactose, a cell wall constituent of Xanthomonas campestris.


Formation of methane from serine by cell-free extracts of Methanobacillus omelianskii.


Carboxypeptidase A. Studies with poly-alpha-amino acids.


Metabolic transformation of cholestenediols.


A cytidine triphosphate polymerase from thymus nuclei. 1. Purification and properties of the enzyme and its polynucleotide primer.


Studies of the stability in vivo and in vitro of rat liver tryptophan pyrrolase.


Studies on the origin of epsilon-N-methyl-L-lysine in protein.


Amino acid sequence of dog heart cytochrome c.


The enzymology of virus-infected bacteria. VII. A new deoxyribonucleic acid polymerase induced by bacteriophage T5.


The clostridial fermentations of choline and ethanolamine. 1. Preparation and properties of cell-free extracts.


The clostridial fermentations of choline and ethanolamine. II. Requirement for a cobamide coenzyme by an ethanolamine deaminase.


Characterization of a human macroglobulin. II. Distribution of the disulfide bonds.


Fat metabolism in higher plants. 28. The biosynthesis of saturated and unsaturated fatty acids by preparations from barley seedlings.


Ribonuclease and oligoribonucleotide synthesis. I. Synthetic activity of bovine pancreatic ribonuclease derivatives.


3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity.


Metabolic requirements for active sodium transport stimulated by aldosterone.


Quantum-mechanical interfacial "trigger" action in macromolecular replication.


Some recent developments in the quantum-mechanical studies on the electronic structure of the nucleic acids.


Experimental cutaneous North American blastomycosis of hamsters.


Histidine and keratinization.

Histidine and keratinization.


The epidermal irregular dense body: correlation of ultrastructural histochemistry with biochemical characteristics.


Localization of melanin synthesis.

Localization of melanin synthesis.


The demonstration of lysosomes in the diseased skin of infants with infantile eczema.


The behavior of melanocytes in inflammation.


On chlorpromazine binding in vivo.

On chlorpromazine binding in vivo.


The affinity of melanin for chloroquine.


Atypical giant cells in Antechinus stuartii due to demodicid mites.


Effect of field size on ultraviolet minimal erythema dose.


The effect of a single dose of ultraviolet radiation on epidermal melanocytes.


Effects of local therapeutic agents upon epidermal macromolecular metabolism.


Effects of podophyllin upon macromolecular metabolism.


Melanin granule dispersion in epidermal melanocytes.


The use of gentamicin in mycology media.


Analogs of tetrahydrofolic acid XXII. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol thymidylate synthetase. 3.


Evaluation of a high-efficiency solids--solids blender.


Colchicine. IV. Neuromuscular transmission in isolated frog and rat tissues.


Essential oils and their constituents. 28. Examination of oil of cardamom by gas chromatography.


Solubility profiles for the xanthines in dioxane--water mixtures.


Some neuropharmacological properties of the ephedrine isomers.


Nonclassical antimetabolites XIX. Simulation of 5'-phosphoribosyl binding. 3. Relative contribution of phosphate and the other oxygen-containing functions to the binding of the 5'-phosphoribosyl moiety to succinoadenylate kinosynthetase.


Isotope effects as tools for the elucidation of reaction mechanisms. Predictions from model calculations.


Cholestyramine in dogs.

Cholestyramine in dogs.


Blood levels of aspirin following the ingestion of commercial aspirin-containing tablets by humans.


Production of thiamine, riboflavin, folic acid, and biotin by Chlorella vulgaris and Chlorella pyrenoidosa.


Use of the triethanolammonium salts of several alkylsulfuric acids as dermatologic vehicles.


Cholinergic anionic receptors. I. Steric requirements for quaternary ammonium inhibitors of acetylcholinesterase.


Chromatographic analysis of the volatile components of papaya fruit.


Potential anticancer compounds with structural relation to podophyllotoxin. Synthesis of 5-(4',5',6'-trimethoxyphenyl)-bis-lactone (3-hydroxymethyl-4-carboxy and 1-hydroxymethyl-6-carboxy)-3,6-cyclohexadiene and related compounds.


Biological disposition of 2-(4-phenyl-1-piperazinylmethyl)cyclohexanone-1-C-14 (C-14-MA1050).


Auto-oxidation of linoleic acid in micellar solution.


Qualitative and quantitative tests for sodium ipodate.


Assay of sodium nitrite.

Assay of sodium nitrite.


Apparatus for automatic end point determination in thermometric titrations.


Separation and estimation of methyl and propyl esters of p-hydroxybenzoic acid by gas chromatography.


Fractionation of fatty acids of Cassia tora seed oil with urea.


Constituents of the fruits of Viburnam opulus.


Synthetic relatives of reserpine.

Synthetic relatives of reserpine.


Biological half-life of psicofuranine in the human.


Mechanism of thermal rearrangement and decarboxylation of procaine.


Tumor inhibitors. 8. Eupatorin, new cytotoxic flavone from Eupatorium semiserratum.


A basic training for general and psychiatric nursing?


A basic training for general and psychiatric nursing.


Cholecystectomy.

Cholecystectomy.


The story of Nicholas.

The story of Nicholas.


The Zollinger-Ellison syndrome.

The Zollinger-Ellison syndrome.


Patient care. 4. Priorities in reconditioning old-fashioned wards.


Nurse in the world of fashion.

Nurse in the world of fashion.


Those Christmas decorations.

Those Christmas decorations.


Staff for non-nursing duties.

Staff for non-nursing duties.


University/basic nursing courses.

University/basic nursing courses.


Improving the effectiveness of psychiatric hospitals.


Flying surgeon.

Flying surgeon.


Determination of sodium anoxynaphthanate (coomassie blue) in blood plasma.


Chronic pulmonary infection in childhood.


The management of asthma.

The management of asthma.


Antibiotics and sulphonamides in respiratory infections.


Acute infective respiratory disease in general practice.


Respiratory disorders in the elderly.

Respiratory disorders in the elderly.


Statistical analysis of parity and gravidity in women with cervical carcinoma and dysplasia.


Respiratory disease as an industrial hazard.


A wetting agent to facilitate ear syringing.


Statement.

Statement.


Casualties in the casualty department.

Casualties in the casualty department.


Reflux cholangitis; etiology and surgical treatment.


The reduction of fetal wastage due to placental insufficiency and adrenal androgenic hyperfunction.


Changing indications for elective splenectomy in childhood.


Attempted suicide with insulin.

Attempted suicide with insulin.


The psychologic effects of gynecic surgery.


The treatment of the unwilling smoker. A clinical approach.


Negro illegitimacy: an antebellum legacy in obstetrical sociology.


Some newer understandings of dreams in relation to threatened abortion and premature labor.


Tubal obstruction: a contraindication for hysterosalpingography.


A new method to regulate the female reproductive cycle--therapeutic indications.


The pattern of work in an industrial practice.


A critical review of nine hundred and sixty-five cesarean sections.


Jejunogastric intussusception.

Jejunogastric intussusception.


Migraine and allergy.

Migraine and allergy.


Treatment of iliofemoral venous thrombosis by thrombectomy.


The Royal National Hospital for Rheumatic Diseases, Bath.


CCXVI. Long-acting isoprenaline.

CCXVI. Long-acting isoprenaline.


The clinical use of clomiphene citrate.

The clinical use of clomiphene citrate.


Rapid qualitative and quantitative hemoglobin fractionation. Cellulose acetate electrophoresis.


Hereditary thrombopathic thrombocytopenia: sex-linked inheritance pattern.


Ventricular septal defect with the "two-chambered right ventricle".


The value of synthetic progestagens in endocrine infertility.


Comparison of the thoracic and abdominal approaches to the repair of esophageal hiatus hernia. Long-term results.


Volvulus of the stomach: report of a case with complications.


Surgical management of recurrent pulmonary emboli preceding hemipelvectomy for chondrosarcoma.


Serial acid-base determinations in normal premature and full-term infants during the first 72 hours of life.


Corticosteroids and varicella. Six-year experience in an asthmatic population.


Reticular system.

Reticular system.


Scleral abscess. I. A complication of retinal detachment. Buckling procedures.


Drug impurities.

Drug impurities.


Moderate hypothermia in man: haemodynamic and metabolic effects.


Blood levels of mepivacaine after regional anaesthesia.


A comparison of the hydrochloride salts of lignocaine and prilocaine for epidural analgesia.


An evaluation of rebreathing in a modified T-piece system during controlled ventilation of anaesthetized children.


Studies of drugs given before anaesthesia. 8. Morphine 10 mg alone and with atropine or hyoscine.


Static electricity in anaesthetic flowmeters eliminated by radioactive pistol.


Studies of drugs given before anaesthesia. IX. Morphine with tacrine.


Diagnosis and treatment of primary myocardial disease.


The clinical concept of primary myocardial disease. A classification and a few notes on management and prognosis.


Treatment of carcinoma of the rectum.

Treatment of carcinoma of the rectum.


Clinical recognition and treatment of primary myocardial diseases. Comments on symposium.


Functional organization of hairy skin in response to sensory stimuli.


Specific impedance of cerebral white matter.


Development of the retinotectal topographic projection in the chick embryo.


Stimulus-response relationships in the cutaneous slowly-adapting mechanoreceptor in hairy skin of the cat.


Selection of appropriate tectal connections by regenerating optic nerve fibers in adult goldfish.


Investigational use of artificial insemination in farm swine.


Intracellular localization of tyrosinase and site of melanin formation in melanocyte.


About the proof of urocanic acid in callus and in normal human horny layer.


A method of preparing three-dimensional casts of the microcirculation of the skin.


Cutaneous thermography with liquid crystals.


Mechanism of percutaneous adsorption. I. Routes of penetration and the influence of solubility.


Studies on pituitary sebotropic activity. I. A new sensitive assay method for sebotropic activity based on beta-glucuronidase content of preputial glands.


Studies of the lipids of dog skin. 3. The in vivo incorporation of acetate, pyruvate, and certain amino acids into the lipids of isolated perfused dog skin.


Immunologic unresponsiveness after topical and oral administration of contact sensitizers to the guinea pig.


Studies on pituitary sebotropic activity. II. Further purification of a pituitary preparation with sebotropic activity.


The antifungal activity of physiologic saline in serum.


Melanin in Langerhans cells.

Melanin in Langerhans cells.


Prophylaxis and control of erythrasma of the toe webs.


Tissue clearance: a critical evaluation of its potential in dermatologic investigation.


Elastase and dermal elastoses.

Elastase and dermal elastoses.


Repository therapy in food allergy.

Repository therapy in food allergy.


Medico-legal brief. The right to die.

Medico-legal brief. The right to die.


An evaluation of two urinary bags as to their biological activity in animals.


Comparative cancer cure statistics.

Comparative cancer cure statistics.


Analysis of factors responsible for the formation of adhesions during chronic peritoneal dialysis.


Autonomic involvement in the lymphatic delivery of fibrinogen.


Fine structure of nerve endings in extraocular muscle.


Further studies on the suppression of corneal hypersensitivity by antimetabolites.


Feature photo. Cystinosis with extensive choroidal involvement.


Human corneal endothelium: growth in tissue cultures.


Changes in the profile following surgical reduction of mandibular prognathism.


What is the auxiliary's role in hospital public relations?


The future in health services; changing values in the search for perfection.


Informal affiliation agreement works best, hospital and nursing facility find.


Computer-based management gaming: a method of executive development.


How PERT (Program Evaluation and Review Technique) simplifies management of hospital programs.


Changing patterns in medical care: their implications for ambulatory services.


Patients learn about diabetes from teaching machine.


Operation 'skyhook'. Selecting wall-mounted equipment to facilitate floor cleaning.


A fresh look at linen handling methods.

A fresh look at linen handling methods.


Vertigo.

Vertigo.


Antibody production by transferred lymphoid cells: inhibition by competition of antigens.


Studies on acquired immunity to coccidiosis in bursaless and thymectomized fowls.


Some observations on fluorescing substances in Trypanosoma cruzi.


The short-term culture of lymphoid tissue from immunized guinea-pigs.


Serum proteins of the grey squirrel (Sciurus carolinensis).


Micro-agglutination test for toxoplasma antibodies.


The value of promethazine hydrochloride in pre-medication.


Anti cancer drugs (cancer chemotherapy).


Trachoma.

Trachoma.


Family planning.

Family planning.


Mechanical devices for contraceptive purposes.


The doctor we want.

The doctor we want.


Serum cations in acute respiratory infections in infancy and childhood.


Association of breath-holding attacks with anaemia and their treatment.


Primary malignant tumour of pericardium: a case report. I. Clinical aspects.


Primary malignant tumour of the pericardium. II. Histopathological aspect.


Turner's syndrome: report of a case.

Turner's syndrome: report of a case.


Malignancy lung. Its manifestations and management.


Laboratory diagnosis of acute abdomen.

Laboratory diagnosis of acute abdomen.


Diazinon poisoning. (A study of 25 cases).


The antipregnancy pill.

The antipregnancy pill.


A preliminary study on the C-reactive protein in ophthalmic disorders.


Classification of leprosy for the clinician.


Clinical trial of pyrithioxine (Encephabol).


Perforation of peptic ulcer. (A case report).


The nature of the earliest spontaneous activity of the chick embryo.


The embryo-forming potencies of the young chick blastoderm.


Inhibition by alpha-methyl-norvaline of valine and leucine uptake into protein in the chick embryo.


The inhibition of cell aggregation by a pure serum protein.


The effects of D- and L-threo-chloramphenicol on the early development of the chick embryo.


Estimation of age at menarche in a population.


Reversible protein-losing enteropathy with intestinal lymphangiectasia secondary to chronic constrictive pericarditis.


Pyridoxine-deficiency neuropathy due to hydralazine.


Pulmonary reactions simulating cardiac pulmonary edema caused by nitrofurantoin.


Beryllium poisoning--lessons in control of man-made disease.


Aspiration of gastric contents in the operative period.


Case records of the Massachusetts General Hospital. Case 51-1965.


Mycoplasma (pleuropneumonia-like organisms) in human disease.


The treatment of syphilis.

The treatment of syphilis.


The treatment of gonorrhoea.

The treatment of gonorrhoea.


Reiter's disease.

Reiter's disease.


The surgical treatment of mitral incompetence.


Estimation of blood glucose by the glucose oxidase strip method.


The prevalence of anaemia in the elderly.


A district medical officer in Basutoland.


General practice and obstetrics.

General practice and obstetrics.


A pilot trial of nortryptiline in the treatment of mentally disturbed patients in general practice.


Carbenoxolone.

Carbenoxolone.


Occupational therapy.

Occupational therapy.


Para-analytic group psychotherapy: a treatment of choice for adolescents.


A case of parricide.

A case of parricide.


Propaedeutic for a family psychiatry.

Propaedeutic for a family psychiatry.


Measurement of capillary blood flow using an electronic double flash light source.


Experimental cutaneous leishmaniasis. II. The pathology of leishmaniasis by Leishmania mexicana.


Simple electromechanical vibration transducer.


Spices and physiological function. Results of recent researches.


The effectiveness ofa non-standardized categorization in differentiating schizophrenic patients of various levels of abstracting functioning.


The psychology of blindfold chess. An introspective account.


Mercury residues in apples from trees receiving organomercurial fungicide in the previous autumn and winter.


Climatic stress indices for domestic animals.


Influence of altitude and cold on pregnancy and lactation of rats fed on two different diets.


Some problems affecting diagnosis and treatment of allergic disorders.


Selecting cases suitable for allergy investigation & treatment.


New concepts in the management of purulent meningitis.


Chemical comforts.

Chemical comforts.


Foreign bodies in the alimentary tract of infants and children.


Pain due to long hamular process in the edentulous patient.


Gains made since "silent spring," but pesticide safety still problem.


Cephalothin. Its in vitro antibacterial spectrum as studied in a diagnostic laboratory. Of 655 bacterial strains isolated in a routine clinical diagnostic laboratory, 564 (86 per cent) were found sensitive to cephalothin by disk sensitivity test. However, the fraction of sensitive Gram-negative bacilli and enterococci declined sharply at concentrations approximating those obtained in serum after the usual recommended dosages. Gram-positive bacteria remained sensitive throughout the entire range of testing concentrations. Unless very high dosages are used, cephalothin cannot be considered a broad-spectrum antibacterial agent for use while cultures are pending. Even with very high dosages all strains of Pseudomonas spp. and significant fractions of other Gram-negative bacillary species remain resistant to cephalothin. If used alone, the high potency cephalothin disk may yield inadequate information and should be supplemented by a lower potency disk, standardized measurements of zone diameters, or a screening plate.


Respiratory viruses. Current status and future prospects. The application of tissue culture technology has revealed several new groups of viruses, comprising scores of different serotypes, as important causes of upper and lower respiratory tract disease in man. Other agents as yet unrecognized undoubtedly exist. Present epidemiologic data, although still incomplete, point up the unique importance of certain of these viruses in respiratory diseases. The particular type and severity of respiratory syndrome produced by a virus is determined by the immune status of the host, by the presence of complicating disease and by characteristics intrinsic in the infecting agent itself. Respiratory virus control might be particularly beneficial in certain groups, particularly persons with allergic sensitivity and chronic pulmonary disease.For control of viral respiratory disease, active immunization would provide significant protection but highly polyvalent vaccines might be necessary. Adjuvants could be helpful in this regard. Certain vaccines formerly in use were produced from strains of viruses which have recently been shown to be oncogenic in animals. In addition, hybridization of viruses can occur, resulting in the incorporation of the oncogenic potential of one agent into the genetic constitution of another. The significance of these biologic phenomena to vaccination programs has yet to be defined.Passive immunization would provide short-lived protection and would find application only in uniquely susceptible populations or at times of augmented risk. Active immunization of pregnant women, however, could provide increased breadth and duration to the transplacental passive immunity in the newborn.Interferon-inducing agents could potentially provide broad spectrum antiviral protection, but the extent and duration of their effectiveness are unknowns. Certain chemical agents have been shown to have prophylactic and therapeutic effects against a limited number of clinically severe viral diseases. Finally, limited data suggest that climatic control in places of public gathering might be worth evaluating as a means of controlling the spread of viral respiratory infections.


Systems for maintenance of urinary sterility after prostatectomy. Closed drainage is recommended for all patients after prostatectomy where hemostasis has been adequate. Although closed drainage can maintain sterility of the bladder, thereby fostering healing and reducing infectious complications, such drainage is not insisted upon at most hospitals because of the inconveniences associated with it. However, when closed drainage was used in 25 consecutive cases of transurethral resection, infection was reduced to 25 per cent (in contrast to the 85 to 100 per cent encountered with open drainage). The ideal closed system should incorporate:1. Fixed tubing to prevent contamination where the catheter joins the tubing and where the tubing is attached to the container;2. An aseptic method of emptying;3. A device to prevent reflux of the potentially contaminated urine in the container into the bladder;4. Free urinary flow from bladder to container; and5. Portability for the patient and convenience for the staff.A system is proposed that incorporates these features. Particularly effective are a fixed drip chamber with vents at the site of attachment of the tubing to the bag and a protected spigot for emptying.


Mortality in spinal cord injuries. Follow-up report. The principal cause among 137 deaths in a series of 1,613 patients with traumatic spinal cord lesions treated at Veterans Administration Hospital, Long Beach, was renal disease attributable to the paralysis of the bladder and bladder sphincter and resultant genito-urinary tract infections. The second ranking cause was pulmonary disease. Before 1960 no deaths from cancer had occurred in this series, but between 1960 and 1962 three patients died of carcinoma of the bladder. It can be expected that as these patients reach higher age groups the incidence of neoplasms will increase.


In defense of the obstetrician and obstetrics. Changes and advances in obstetrics are emphasized by the comparative study of private and one hospital practice in 1939 and 1964. Education, prenatal care, anesthesia, antibiotics, transfusions have all been instrumental. Old problems-abortion, toxemia, prematurity, developmental abnormalities-remain with us. New developments, both professional and economic, some not desirable, face us and demand that active practicing obstetricians take an active role in helping direct their course.


Coccidioidin retest reaction. Observations of tests on a coccidioidin-sensitive person. The retest coccidioidin reaction in an apparently healthy person known to be coccidioidin-positive developed more quickly and was of a greater magnitude than that of an equivalent test in a virginal site in the same person. In both reactions, erythema, induration and/or edema were evident. Although the peak of the retest reaction was at 12 hours, readings made at 24 and 48 hours were in a definitively positive category.


Clinical neurology. Some applications of scanning by computer. The use of averaging techniques permits a great increase in the resolution of time-locked waveforms in the electroencephologram. Averaged evoked potentials may be used to study sensory-sensory interactions and the effect of irritative and destructive lesions on the average evoked potential. More complex computations are possible once averages are derived, as was shown in the application of potential contour mapping, where considerable differences were noted between premature and newborn infants on the one hand and adults on the other. The flat, low voltage surface potential contour of the neonate was interpreted as reflecting a volume-conducted event having a distant, deep and midline source. Potential contour patterns in the adult were interpreted as showing predominantly neuronally propagated activity arising at the cortical surface.


Use of a serosal patch in repair of a duodenal fistula. Clinical application of an experimental method.


Esophageal hiatal hernia following vagotomy.


Infectious mononucleosis with high heterophile titer and neurological manifestations.


Vehicles, ipsatization, and the multiple-method measurement of motivation.


The effect of a brief interpolated task on short-term retention.


Very early weaning, weaning stimulation, and the adult exploratory and avoidance behaviour of white rats.


Presentation rate, repetition, and organization in auditory short-term memory.


Motivational differences affecting the behaviour of descendants of tryon "bright" and "dull" rats.


Dorsal and ventral hippocampus lesions and maze learning: influence of preoperative environment.


The effect of white noise upon the recall of vocalized lists.


Mediated associations: paradigms, controls, and mechanisms.


A method for the determination of free plasma amino acids in ultra-micro quantities.


Free and bound amino acids in human urine from normal subjects and patients with tropical sprue.


The urinary excretion of "free" and "peptide" amino acids by a patient with thermal burns.


The employment on DEAE-cellulose columns of a "rejection" principle in the preparation of factor VII.


Glass electrode measurement of cerebrospinal fluid sodium and potassium.


Creatinine determination in the urine of alcaptonuric patients.


A colorimetric method for the estimation of urinary formiminoglutamic acid.


A simple modified micromethod for the determination of citrate.


A new colour reaction for ammonia and primary amines.


The colorimetric ninhydrin reaction for estimation of alphaamino nitrogen and its application to cerebrospinal fluid.


A fluorometric assay and properties of leucocyte alkaline phosphatase.


Human serum cholesterol synthesis.

Human serum cholesterol synthesis.


An evaluation of an automated system for determination of proteinbound iodine.


Cholesterol ester fatty acid composition of human aorta fatty streaks and normal intima.


Elastogenesis in human aorta: an electron microscopic study.


Typhoid fever in children.

Typhoid fever in children.


Biochemical and cellular changes occuring during conjugation in Hansenula wingei. Brock, Thomas D. (Indiana University, Bloomington). Biochemical and cellular changes occurring during conjugation in Hansenula wingei. J. Bacteriol. 90:1019-1025. 1954.-A technique has been devised for deagglutinating mixed populations of conjugating cells so as to be able to visualize microscopically early stages of the conjugation process. A cell can form a conjugation tube only when in contact with a cell of opposite mating type, but may do so even if the mate is unresponsive or ultraviolet-inactivated. Cell fusion occurs, however, only when both cells are able to form conjugation tubes in a region of contact. Fusion begins almost as soon as the two cells begin to form protuberances, and long before any dissolution of cell-wall material between the cells occurs. A cell which has conjugated in one region of its cell wall is still able to conjugate with another cell in another region, so that triply and quadruply conjugated cells are occasionally formed. There is no significant net increase in deoxyribonucleic acid, ribonucleic acid, protein, or carbohydrate which might be related to the conjugation process, because any minor changes that occur in these components are also detected when cells of only one mating type are incubated or when the conjugation process is inhibited with the antibiotic cycloheximide. Changes in activity of beta-1,3-glucanase (with laminarin as substrate) and beta-1,6-glucanase (with pustulan as substrate) have been measured during the conjugation process, in addition to changes in the activity of several control enzymes which would not be expected to be related to the conjugation process. Significant increases in invertase (sucrase), laminarinase, and pustulanase were detected, and minimal increases occurred in beta-glucosidase and acid phosphatase. However, these same increases were also observed in controls involving only one mating type; thus, these increases are probably not related to the conjugation process, but may be a result of other processes which probably occur during incubation in the conjugation medium.


Microbiological method for the determination of L-tryptophan. Sebek, Oldrich K. (The Upjohn Company, Kalamazoo, Mich.). Microbiological method for the determination of l-tryptophan. J. Bacteriol. 90:1026-1031. 1965.-The ability of Chrombacterium violaceum to utilize l-tryptophan for the synthesis of a purple pigment, violacein, served as a basis for the development of a quantitative estimation of this amino acid. The method consists of suspending washed colorless cells of the organism in an agar layer, placing a paper disc impregnated with a tryptophan solution on top of the layer, and allowing the system to incubate. As tryptophan diffuses into the agar, it is converted into violacein, and appears as a zone of striking purple color. Since the diameter of the zone is a function of the amount of tryptophan applied, the amino acid can be quantitatively estimated within the range of 10 to 320 mug per sample with 5.6% standard deviation. The method is fairly specific for free tryptophan, since only indole, indole-3-pyruvic acid, and, to a small degree, anthranilic acid interfere. Other amino acids, tissue homogenates, tryptophan in peptide linkage, or compounds related to this amino acid do not affect its determination. The bacterium does not utilize tryptophan for the synthesis of cellular material unless its growth has been initiated by another substrate.


Effect of 2-deoxyglucose on Schizosaccharomyces pombe. Megnet, Roland (Institut für Allgemeine Mikrobiologie der Universität, Bern, Switzerland). Effect of 2-deoxyglucose on Schizosaccharomyces pombe. J. Bacteriol. 90:1032-1035. 1965.-Cultivation of Schizosaccaromyces pombe in a medium containing 2-deoxyglucose (100 mug/ml) results in the death of the cells after an initial period of apparently normal growth. At higher deoxyglucose concentration (400 mug/ml), the cells die immediately after inoculation. Only growing cells are killed, and microscopic inspection of the cultures reveals cell-wall fragments of lysed cells. A mutant resistant to 2-deoxyglucose, which cannot use glucose as a carbon source, was found to be partially deficient in hexokinase. The data constitute evidence for the inhibition of some reaction(s) in the synthesis of cell-wall polysaccharides by metabolites of 2-deoxyglucose in this organism.


Bacillary necrosis, a disease of larval and juvenile bivalve mollusks. I. Etiology and epizootiology. Tubiash, Haskell S. (U.S. Bureau of Commercial Fisheries, Milford, Conn.), Paul E. Chanley, and Einar Leifson. Bacillary necrosis, a disease of larval and juvenile bivalve mollusks. I. Etiology and epizootiology. J. Bacteriol. 90:1036-1044. 1965.-Lethal bacterial infections of a variety of hatchery-spawned bivalve mollusk larvae and juveniles have been studied. The symptoms of the disease and the course of the infection are described. Four biotypes and five antigenic types of bacteria, pathogenic for the larvae of five species of bivalve mollusks, were isolated and described in some detail. All are gram-negative motile rods. Comparative studies were made of a fairly large number of similar bacteria isolated from presumably normal marine fauna. None of these was pathogenic for the bivalve larvae nor did they have antigens in common with the pathogenic group. The four biotypes had a number of characteristics in common that rarely were present in other cultures from marine fauna. Several antibiotic preparations proved to be of value in the treatment and control of the infection.


Cell division in a species of Erwinia. IX. Electron microscopy of normally dividing cells. Grula, E. A. (Oklahoma State University, Stillwater), and Gerald L. Smith. Cell division in a species of Erwinia. IX. Electron microscopy of normally dividing cells. J. Bacteriol. 90:1054-1058. 1965.-Cells of an Erwinia species (an Enterobacteriaceae) divide by concomitant invagination of the cell wall and membrane. It is concluded that the process is initiated and sustained by the cell membrane.


Electron microscopy of chromatophores of Rhodopseudomonas spheroides. Gibson, K. D. (St. Mary's Hospital Medical School, London, England). Electron microscopy of Rhodopseudomonas spheroides. J. Bacteriol. 90:1059-1072. 1965.-Fixed and stained chromatophores and whole cells of anaerobically grown Rhodopseudomonas spheroides were examined in thin sections in the electron microscope. Both purified chromatophores and intracellular membrane-bound vesicles had exactly the same appearance, namely that of spheres or ellipsoids with a thin electron-dense shell surrounding an electron-lucent interior. The distribution of diameters in the two types of structure was also found to be the same, and was compatible with a normal distribution, with a mean of 570 A and a standard deviation 40 A. Negatively stained chromatophores appeared like discs or collapsed spheres. The presence of invaginations of the cytoplasmic membrane in this species was confirmed, and a new structure resembling a twin chromatophore was observed. The bearing of these results on theories of the origin of chromatophores is discussed, and it is concluded that they offer some support for each one of the three main theories about the origin of particulate organelles.


Relationship of the major constituents of the Neurospora crassa cell wall to wild-type and colonial morphology. Mahadevan, P. R. (The Rockefeller Institute, New York, N.Y.), and E. L. Tatum. Relationship of the major constituents of the Neurospora crassa cell wall to wild-type and colonial morphology. J. Bacteriol. 90:1073-1081. 1965.-The relationship of cell wall to morphology in Neurospora crassa was studied by correlating the levels of structural polymers of the cell wall with wild-type and colonial morphology. The cell wall of N. crassa contains at least four major complexes: a peptide-polysaccharide complex; two glucose polymers, one of which was found to be a laminarinlike beta-1,3-glucan; and, lastly, chitin. The levels of one or more of these structural polymers are consistently altered in single-gene mutants with colonial growth, and in sorbose-induced colonial growth. The proportions of these polymers, particularly of the peptide-polysaccharide complex and the beta-1,3-glucan, appear to be important to morphology.


Electron microscopy of bundled flagella of the curly mutant of Salmonella abortivoequina. Mitani, Michiko (National Institute of Genetics, Mishima, Japan), and Tetsuo Iino. Electron microscopy of bundled flagella of the curly mutant of Salmonella abortivoequina. J. Bacteriol. 90:1096-1101. 1965.-The arrangement of flagella was observed by dark-field and electron microscopy in three strains of Salmonella abortivoequina, namely, normal flagellar, curly flagellar, and paralyzed curly flagellar strains. With dark-field microscopy, bundled flagella could be seen in 5 to 10% of actively moving normal or curly mutant cells. Under the electron microscope, a great many bundled flagella were observed in the curly mutant strain, but in the normal strain most of the flagella were dissociated or the bundles were rather loose and irregular. Normal flagella seem to separate easily during the process of preparation, but not the curly ones. Single flagella were found to run parallel with each other and to form a bundle consisting of five or more flagella; the bundle was spirally gyrating, with the characteristic flagellar wave. It is thought that the bundle observed with the electron microscope corresponds to that observed under the dark-field microscope. Further, the marked decrease of bundle formation in the paralyzed curly mutant cells suggests that bundle formation is not caused by curly flagellar structure per se, but corresponds to the mode of locomotion of peritrichously flagellated bacteria.


Effect of particle aggregation on the survival of irradiated vaccinia virus. Galasso, G. J. (University of North Carolina School of Medicine, Chapel Hill), and D. G. Sharp. Effect of particle aggregation on the survival of irradiated vaccinia virus. J. Bacteriol. 90:1138-1142. 1965.-The survival curve (plaque titer versus time) of vaccinia virus irradiated with ultraviolet light was found to be strongly dependent, in both shape and general slope, on the degree of aggregation among the virus particles. When special care was taken to produce completely dispersed virus, a straight steep line resulted. Some severely aggregated preparations produced a straight line also, but of much less slope. Thus, the straight line, often taken as evidence of complete dispersion, is not a reliable measure for vaccinia virus. None of the experimental curves resembled the classical multihit curve predicted by the Poisson function for the behavior of uniformly aggregated virus. The aggregation was observed, by electron microscopy, to be nonuniform, and of such a distribution that the survival curves can be qualitatively accounted for in terms of multiplicity reactivation of irradiated virus within cells that receive groups of two or more particles. The greatly increased survival value of aggregates of virus, which indicates multiplicity reactivation, is worthy of note.


Immunochemical studies on alpha-amylase. 3. Immunochemical relationships among amylases from various microorganisms. Sirishinha, Stitaya (University of Rochester School of Medicine and Dentistry, Rochester, N.Y.), and Peter Z. Allen. Immunochemical studies on alpha-amylase. III. Immunochemical relationships among amylases from various microorganisms. J. Bacteriol. 90:1120-1128. 1965.-Immunochemical relationships among amylases obtained from a selected group of microorganisms were examined, and a cross-reaction was detected between the alpha-amylases of Bacillus stearothermophilus and B. subtilis. Immunodiffusion and quantitative precipitin studies, as well as cross-neutralization tests, indicate that B. stearothermophilus alpha-amylase reacts with a portion of antibody present in antisera to crystalline B. subtilis alpha-amylase. Amylases from these two species thus have some aspects of structure in common. Limited data obtained by immunodiffusion suggest that groupings which confer cross-reactivity to the B. stearothermophilus enzyme are lost after exposure to mercaptoethanol in the presence of ethylenediamine-tetraacetate, followed by treatment with iodoacetamide. With the antisera employed and within the concentration range examined, no immunochemical cross-reaction was observed among amylases from Aspergillus oryzae, B. subtilis, B. polymyxa, B. macerans, Pseudomonas saccharophila, and Euglena sanguinis. Immunoelectrophoresis of partially purified B. stearothermophilus alpha-amylase by use of antiserum to the crude enzyme, together with localization of amylase activity in immunoelectrophoretic plates, suggests that B. stearothermophilus alpha-amylase is antigenic in the rabbit.


Deoxyribonucleic acid base composition and Adansonian analysis of heterotrophic aerobic pseudomonads.


Biochemical changes in lysogenic Bacillus stearothermophilus after bacteriophage induction. Welker, N. E. (University of Illinois, Urbana), and L. Leon Campbell. Biochemical changes in lysogenic Bacillus stearothermophilus after bacteriophage induction. J. Bacteriol. 90:1129-1137. 1965.-Cultures of Bacillus stearothermophilus 1503-4R (TP-1) continued to grow at an unaltered rate after induction with mitomycin C (MC). MC-induced cultures exhibited a 2.5-fold increase in cell number before lysis occurred. Prior to lysis, cells were observed to elongate and to contain areas of lesser density. Protein synthesis was slightly inhibited in MC- or ultraviolet light (UV)-induced cultures for a period of 5 to 10 min, and then proceeded at a rate identical to that in the noninduced culture. Ribonucleic acid (RNA) synthesis was not affected by MC induction. UV induction caused RNA synthesis to occur in two stages: in the first stage, the rate of RNA synthesis was one-third that observed in the noninduced culture and lasted for a period of 15 min; the second stage of RNA synthesis then proceeded at a rate identical to that in the noninduced culture. The synthesis of deoxyribonucleic acid (DNA) in an MC- or UV-induced culture occurred in two stages. In the first stage, DNA synthesis in induced cultures occurred at a rate of one-half (MC) and one-third (UV) of that observed in the noninduced culture. The first stage of DNA synthesis in MC- or UV-induced cultures lasted for 25 to 30 min and 15 to 20 min, respectively. In the second stage, the rate of DNA synthesis in MC- or UV-induced cultures occurred at a rate three times that of the noninduced culture. UV induction appeared to have a greater inhibitory effect than MC induction on protein, RNA, and DNA synthesis as well as phage yield. The differential rate (K) of inducible and constitutive alpha-amylase synthesis was inhibited by 75 and 100%, respectively, for a period of 20 min after MC induction. After 20 min, the K values for alpha-amylase synthesis were identical to those obtained in the absence of MC induction. The synthesis of TP-1 phage DNA occurred rapidly and was complete 25 min after MC induction, whereas bacterial DNA was degraded or its rate of synthesis was decreased. During the second stage of DNA synthesis, only bacterial DNA was synthesized, but at a rate greater than that found in the noninduced culture.


Auxotrophic mutation and infectivity of Agrobacterium tumefaciens.


Growth of Aerobacter aerogenes on D-arabinose and L-xylose.


Biotin transport and accumulation by cells of Lactobacillus plantarum. I. General properties of the system. Waller, James R. (University of Cincinnati, Cincinnati, Ohio), and Herman C. Lichstein. Biotin transport and accumulation by cells of Lactobacillus plantarum. I. General properties of the system. J. Bacteriol. 90:843-852. 1965.-Resting cells of Lactobacillus plantarum were saturated with bound biotin by incubation in phosphate buffer with biotin and glucose for 2 hr. This bound biotin was stable to wide changes in temperature, pH, and reaction time. Free biotin could be eluted from the cells by suspending them in cold water or saline. Immersing the cells in boiling water for 30 sec released all free biotin. Recoveries of added biotin exceeded 92%. Free biotin uptake by bound biotin-saturated cells occurred by two mechanisms. One process was independent from temperature (Q(10), 1.25), pH, cellular metabolism, and inhibition by iodoacetate. The other mechanism was dependent upon temperature (Q(10), 2.58; optimum, 37 C), pH (optimum, 7.5), and active cellular metabolism, and was inhibited by iodoacetate. Activation energies of 3,700 and 13,800 cal per mole, respectively, were observed for glucose-independent and -dependent free biotin uptake. Both processes exhibited approximately the same degree of inhibition by homobiotin. Higher concentrations of homobiotin were required to inhibit growth than to inhibit free biotin uptake. Intracellular-extracellular ratios as high as 600 were established in the absence of glucose, whereas ratios of nearly 4,000 occurred in the presence of glucose.


Biotin transport and accumulation by cells of Lactobacillus plantarum. II. Kinetics of the system. Waller, James R. (University of Cincinnati, Cincinnati, Ohio), and Herman C. Lichstein. Biotin transport and accumulation by cells of Lactobacillus plantarum. II. Kinetics of the system. J. Bacteriol. 90:853-856. 1965.-Bound biotin-saturated cells of Lactobacillus plantarum accumulated free biotin by a time-dependent process exhibiting substrate saturation phenomena in the presence and absence of glucose. Apparent K(m) and V(max) values determined in the presence and absence of glucose, respectively, from Lineweaver-Burk plots were found to be 31.5 and 7.72 mmum (K(m)) and 9.72 and 3.26 mumumoles per mg per min (V(max)). Free biotin transport per se appeared to be an energy-independent, mediated process, whereas the accumulation of large intracellular vitamin concentrations was energy-dependent. Internal free biotin was quantitatively converted to bound biotin. The rate and extent of bound biotin formation was slower than free biotin uptake, and dependent upon intracellular free biotin levels up to a saturating concentration.


Numerical taxonomy of some bacteria isolated from antarctic and tropical seawaters. Pfister, Robert M. (Lamont Geological Observatory, Palisades, N.Y.), and Paul R. Burkholder. Numerical taxonomy of some bacteria isolated from Antarctic and tropical seawaters. J. Bacteriol. 90:863-872. 1965.-Microorganisms from Antarctic seas and from tropical waters near Puerto Rico were examined with a series of morphological, physiological, and biochemical tests. The results of these analyses were coded on punch cards, and similarity matrices were computed with a program for an IBM 1620 computer. When the matrix was reordered by use of the single-linkage technique, and the results were plotted with four symbols for different per cent similarity ranges, nine groups of microorganisms were revealed. The data suggest that organisms occurring in different areas of the open ocean may be profitably studied with standardized computer techniques.


Effect of 5-fluorouracil on the growth of bacteriophage R17. Graham, A. F. (The Wistar Institute of Anatomy and Biology, Philadelphia, Pa.), and Clare Kirk. Effect of 5-fluorouracil on the growth of bacteriophage R17. J. Bacteriol. 90:928-935. 1965.-When added to Escherichia coli within 2 min after phage R17, 5-fluorouracil (FU), at a concentration of 10(-4)m, completely inhibited the synthesis of infectious ribonucleic acid (RNA) and phage. If the addition of FU was made later than 5 min after infection, infectious RNA synthesis was blocked but infectious phage was still formed; the infectious RNA made before the addition of FU continued to be incorporated into mature phage. These properties of the inhibitor were used to determine the kinetics of phage RNA synthesis and the size of the phage precursor RNA pool. At a concentration of 2.2 x 10(-5)m FU, the yield of phage was reduced to 15% of that in an uninhibited control, 28% of the phage RNA uracil was replaced with FU, and the specific infectivity of the phage was unaltered.