The distribution and urinary excretion of decamethonium and hexamethonium following intravenous injection into mice.


A survey of the nutritive value of brewery and distillery by-products.


Sodium chloride depletion and renal concentrating ability during chronic administration of thiazide (Centyl) and furosamide (Lasix) to the normal rat.


Studies on riboflavin metabolism in the rat. I. Urinary and faecal excretion after oral administration of riboflavin-5'-phosphate.


Studies on riboflavin metabolism in the rat. IV. Riboflavin elimination after exclusion of the portal circulation.


Studies on riboflavin metabolism in the rat. 3. Disappearance rate and urinary excretion rate of flavin after intravenous infusion of riboflavin-5'-phosphate.


Failure to produce heparin osteoporosis in rats.


The effect of protriptyline on dopamine and noradrenaline metabolism in normal and atrophied rat salivary glands in vitro.


Activities of monoamine metabolizing enzymes in rat salivary glands: a comparison between tissue slices and homogenates.


The NIAID: its role and goal.

The NIAID: its role and goal.


Breast-and formula-feeding of infants.

Breast-and formula-feeding of infants.


Experimental hydrocephalus produced by the subarachnoid infusion of silicone oil.


Lymphosarcoma in the cat.

Lymphosarcoma in the cat.


Cesium-137 and strontium-90 in Florida milk--a five-year study of distribution and levels.


Small health group builds big success in the Southwest.


A case of equine lymphosarcoma.

A case of equine lymphosarcoma.


A method for the estimation of individual urinary corticosteroids, pregnanediol, pregnanetriol and pregnanetriolone following their separation by thin-layer chromatography.


Nutrition problems and programs in the District of Columbia.


A comparison of effects of some 6-azapyrimidines with and without antimetabolite activity on the central nervous system.


State of Maine Department of Health and Welfare. Division of Chile Health--Objectives and activities.


Prematurity and retrolental fibroplasia.


Effect of DL-ethionine on the intestinal absorption and transport of palmitic acid-1-14C and tripalmitin-14C. Role of intramucosal factors in the uptake of luminal lipids. The effect of DL-ethionine on the uptake and transport of lipid by the rat small intestine was investigated. A cottonseed oil emulsion containing (14)C-labeled tripalmitin or palmitic acid was administered intragastrically to rats pretreated with DL-ethionine, DL-ethionine plus methionine, or saline, and the rats were sacrificed 2, 4, and 6 hr later. Lipids from the plasma, the stomach, the colon, the luminal contents of the small intestine, and the wall of the small intestine were extracted, fractionated, and their radioactivity assayed. Ethionine markedly inhibited the uptake of lipids by the small intestine. This inhibition was not related to impairment of intraluminal lipolysis since analagous inhibitions were observed when palmitic acid or predigested triglyceride (TG), obtained through a jejunal fistula from normal animals, was administered instead of tripalmitin. Ethionine also inhibited the transport of lipid from the wall of the small intestine. A significant fraction of the administered lipid remained in the wall of the small intestine, and only a small fraction was transported to the blood stream. Although most of the wall radioactivity was in the form of TG, significant proportions were also found in the free fatty acid (FFA) and partial glyceride fractions, indicating a marked inhibition of mucosal reesterification to TG. The degree of inhibition of mucosal reesterification and the degree of inhibition of transport of wall lipids were directly related to the degree of inhibition of uptake of luminal radioactivity. This relationship suggests that the rate of reesterification, the level of mucosal FFA, and the rate of transport of intramucosal TG may be of importance in determining the extent of uptake of intraluminal lipid by the mucosal cells. Since a significant fraction of the wall radioactivity was in the form of TG, the decreased transport of wall lipids was attributed to an impairment of chylomicron completion due to inhibition of either the synthesis of chylomicron apoprotein or the association of preformed TG with the protein moiety of chylomicrons. Experiments with labeled amino acids support the first possibility.


Oestrogen binding in the mouse uterus: 17 beta-oestradiol and meso-hexoestrol compete for the binding sites.


Concentrations of amitriptyline and its metabolites in urine, blood and tissue in fatal amitriptyline poisoning.


Interaction of DOPA decarboxylase inhibitors with the effect of alpha-methyldopa on blood pressure and tissue monoamines in rats.


Uptake of mercury vapour in blood in vivo and in vitro from Hg-containing air.


The effect of thioridazine and promazine on the isolated contracting rat heart.


Excretion of phenobarbitone in urine after intake of large doses.


Changes in coronary flow and ECG in the isolated perfused rat heart induced by phenothiazine drugs.


Some aspects of clopenthixol metabolism in rats and humans.


The sensitivity of adrenergic excitatory and inhibitory receptors in the smooth muscle of the rabbit urinary bladder.


The fate of intracerebroventribular injection of atropine and methylatropine in relation to their pharmacological effects.


The interaction between different metabolic pathways of catecholamines in the brain studied by means of 3H-DOPA.


On the metabolic disposition of methylatropine in animals and man.


Auto-immune thyroiditis.

Auto-immune thyroiditis.


Follicular hyperplasia in lymph nodes from patients with rheumatoid arthritis. A clinicopathologic study.


Lymphoma of the gastrointestinal tract: prognostic guides based on 162 cases.


Clinico-pathologic conference from the Metropolitan Veterinary Practitioner's Society of New York.


If it's published, you can find it.

If it's published, you can find it.


Reorganization--psychopharmacology research branch, NIMH.


Equine ehrlichiosis.

Equine ehrlichiosis.


Kinetics of blood-cerebrospinal fluid glucose transfer in the normal dog.


Recurrent pneumonia in Indian children.

Recurrent pneumonia in Indian children.


Altered split-dose recovery in mice irradiated under hypoxic conditions.


The molecular and crystal structure of 6-methoxy-8-nitro-5(1H)-quinolone and its dielectric properties.


Lactase deficiency in Thailand: effect of prolonged lactose feeding.


Specificity of the Paul-Bunnell test.

Specificity of the Paul-Bunnell test.


MAG in AMA.

MAG in AMA.


Ester production by Pseudomonas fragi. II. Factors influencing ester levels in milk cultures. Cultures of Pseudomonas fragi were grown at 21 C in sterile homogenized milk and reconstituted skim milk media supplemented with ethyl alcohol. Quantitative determinations of ethyl butyrate and ethyl hexanoate by gas-liquid chromatography showed definite increases in the concentrations of the two esters produced in these media in comparison to media not supplemented with ethyl alcohol. Supplementation with butyric acid in addition to ethyl alcohol generally elevated the ethyl butyrate concentration and usually depressed the cell count slightly. Aeration of any of the media during growth tended to reduce the cell population slightly. A relationship between increase in cell number and increase in concentration of esters during the growth of the culture was observed. Media containing high concentrations of ethyl alcohol plus milk fat or low-molecular-weight fatty acids were conducive to the production of a fruity aroma by P. fragi.


Toxic diffuse goiter in children.

Toxic diffuse goiter in children.


Leslie County Health Program.

Leslie County Health Program.


From the files of the committee for the study of maternal mortality.


Southeastern Kentucky Regional Health Demonstration Project for 68-69.


Neighborhood Health Center, Louisville.

Neighborhood Health Center, Louisville.


Reorganization, objectives and changes in AMA.


Changes in medicaid.

Changes in medicaid.


FDA and Panalba: a conflict of commercial, therapeutic goals?


Determination of protein binding values of aminopyrine, 4-aminoantipyrine and N-acetyl-4-aminoantipyrine in bovine plasma and milk.


Intrathecal methotrexate therapy of brain tumors of childhood.


Is there an effective acceptable procedure for virus removal? Status of betaprone for cold sterilization of biologic products.


MEDLARS demand search service and the Wisconsin physician.


Crystal and molecular structure of beta-bromoprogesterone.


A sociological evaluation of the Watts neighborhood health center.


On the unit-cell dimensions and space group of L-tyrosine and L-tryptophane.


The crystal and molecular structure of pyridoxal phosphate oxime.


Phase determination for the estriol structure.


Estrogenic steroids. 3. The crystal and molecular structure of estriol.


The crystal and molecular structure of a dinucleoside phosphate: beta-adenosine-2'-beta-uridine-5'-phosphoric acid.


X-ray crystal analysis of the substrates of aconitase. IX. A refinement of the structure of anhydrous citric acid.


The crystal and molecular structure of quinuclidinyl benzilate hydrobromide.


Establishment of the stable geometric isomer of an alpha-arylidenelactone: alpha-(2-hydroxy-3,5-dibromobenzylidene)-gamma-butyrolactone.


The influence of valence electron scattering on the results of x-ray structure analyses.


Relating a neighborhood health center to a general hospital: a case history.


The crystal structure of capaurine hydrobromide.


X-ray studies of C25 terpenoids. 3. The crystal structure of ceroplastol  p-bromobenzoate.


Implementing Head Start health goals in New York City.


The crystal and molecular structure of 6-mercaptopurine monohydrate.


The crystal and molecular structure of 6-mercaptopurine monohydrate. A second, independent x-ray diffraction determination.


The crystal structure of thiamine pyrophosphate.


Fractionation of spleen and serum in attempts to isolate the radiation-leukemia protection factor.


Skin nucleic acid phosphorus metabolism of DBA-1J mice during implanted tumor development and methylcholanthrene carcinogenesis.


Developmental characteristics of infants surviving fetal transfusion.


Problems facing the Negro in medicine today.


Problems of the predominantly Negro medical school.


Enrollment of black students in professional and graduate study. A program to increase enrollment at the University of Florida.


Black student recruitment at the University of Washington.


Enigmatic chest mass.

Enigmatic chest mass.


Enzymes and pancreatic inflammation.

Enzymes and pancreatic inflammation.


Anxiety and pain.

Anxiety and pain.


Psychological microbes.

Psychological microbes.


Bleeding renal vascular malformations.

Bleeding renal vascular malformations.


Quadriplegia in diabetic hyperosmotic coma.


Continuous aneroid arterial pressure monitor.


Psychotogenic effect of marihuana.

Psychotogenic effect of marihuana.


Pseudogynecomastia due to penicillin adjuvant.


Synovial cyst of ischial tuberosity in Felty's syndrome.


Allergic reaction to penicillin in milk.


Sympathetic ophthalmia, a disappearing disease.


Developing gap in immunity to poliomyelitis in an urban area.


Serum heat-stable lactate dehydrogenase in the diagnosis of myocardial infarction.


Primary disseminated pulmonary aspergillosis with metastatic skin nodules. Successful treatment with inhalation nystatin therapy.


A profile of 314 Americans graduating form foreign medical schools.


Clinical temperature. New physiological basis.


Council on drugs. List No. 82. New names.


Medicine and the laity.

Medicine and the laity.


Toxemia, placenta, and immunity.

Toxemia, placenta, and immunity.


"The Phaedra complex".

"The Phaedra complex".


Asbestos dust--a community hazard?

Asbestos dust--a community hazard?


Learning disabilities.

Learning disabilities.


Disseminated herpes simplex with encephalitis in a neonate. Treatment with idoxuridine.


Large doses of procainamide for paroxysmal ventricular tachycardia.


Thoracic origin of a single renal artery.


Aminophylline dosage.

Aminophylline dosage.


Oxido steroids I: the crystal structure of 11beta, 12alpha-dibromo-3alpha, 9-oxidocholanic acid methyl ester.


The crystal and molecular structure of 3beta,17alpha-dihydroxy-16beta-bromo-5alpha-pregnan-11,20-dione and its comparison with the related-16beta-bromo-3beta-acetate and -21-bromo-3beta-ol steroids.


The excretion of dopamine and dopamine metabolites in Parkinson's disease and the effect of diet thereon.


Observations on the fine structure and development of the spindle at mitosis and meiosis in a marine centric diatom (Lithodesmium undulatum). I. Preliminary survey of mitosis in spermatogonia.


A microspectrofluorimeter with epi-illumination and photon counting.


A sandwich-embedding technique for monolayers of cells cultured on Araldite.


Increasing the camera constant of the EM6 microscope.


A device for trimming frozen biological tissue preparatory to ultra-thin sectioning.


A simple cooling device for thin paraffin sectioning.


Energy dependent nucleolytic processes are responsible for the production of many post-irradiation breaks in L cell DNA.


Patterns of venereal disease morbidity in recent years.


Two unusual intrarenal vascular lesions treated by conservative surgery.


Biological properties of human chorionic gonadotropin.


Ovarian secretion of progesterone and 20alpha-hydroxypregn-4-en-3-one during rat estrous cycle in chronological relation to pituitary release of luteinizing hormone.


Causal relationship between luteinizing hormone release and estrogen secretion in the rat.


Effects of steroids on the release of luteinizing hormone in the rat.


Alteration by neonatal hypothyroidism of the critical period for the induction of persistent estrus in the rat.


Partial separation of gonadotropin-inhibiting substance in human urine.


Plasma human growth hormone levels 4 hours after breakfast in adolescent twins and adults.


A case of adrenocortical cancer treated with O,P'-DDD.


Purification and properties of a lymphoid acid ribonuclease.


The detection and characterization of 11-deoxycortisol (Compound S) in late pregnancy urine.


The effect of ascorbic acid on adrenal activity during vitamin A and riboflavin deficiencies in chicks. (Adrenal activity in vitamin deficiency).


Simplified dexamethasone suppression test.


The effect of protein deficiency on uterine sensitivity in the pseudopregnant rat.


Influence of renal nerves on the secretion of aldosterone in the rat.


Oestrogen-induced glycogenesis in the uteri of fasted and insulin-treated hypoglycaemic rats.


Studies with 4-14C-lynestrenol in normal and lactating women.


Natriuretic activity of 16-alpha-hydroxyprogesterone in man.


Cytological and cytochemical comparative study on the effect of cyproterone (anti-androgen) and gonadectomy on the gonadotrophic cells of the hypophysis in male rats.


Studies on sex hormone excretion in normal and hirsute women.


Persistent levels of phosphorylase in the rat ovary after oestradiol and gonadotrophin treatment.


Response of neonatal female rats to reserpine and testosterone.


Oestriol concentration in amniotic fluid.


An electron microscopic study of the parathyroid glands in man: evidence of secretory material.


The action of oestradiol benzoate on the activities of some polypeptidases in the hypothalamus of the pregnant rabbit after blastocyst implantation.


Hypercalcemia of complex etiology: a case report.


Anatomic studies of the distribution and effects of intrathecal radioactive gold.


The shifts of electrolyes and radioactive ions in the myocardium during various cardiotoxic interventions and administration of some potassium and magnesium salts.


A new benzodiazepine: electroencephalographic studies of its anticonvulsant activity in non-anesthetized, non-curarized rabbits.


Spectrofluorophotometric determination of daunomycin in the tissues.


Study of the metabolism of bamifylline in man.


Observation on the problems accompanying antibiotic treatment in bronchitis with recurrent infection.


The efficiency of bithionol in the treatment of dog tapeworms.


An apparatus for fixation and continuous dehydration of specimens for paraffin sections.


Twenty-four-hour films as an aid in the recognition of mixed injections (subarachnoid, subdural, and epidural) in Pantopaque myelography.


Target gland insufficiency and pituitary tumours.


Follicle stimulating hormone-like activity in human chorionic gonadotrophin preparations.


Effect of thiourea on ovulation in vitro in the skipper frog, Rana cyanophlyctis (Schn).


A terminology for units of biological and immunochemical activity.


Overweight in offspring of cortisone-treated pregnant rats.


Distribution of radioactivity in the different lobes of the rat prostate following administration of testosterone-1,2-3H.


Hormonal influence on fibrinolytic activity of uterus and vagina in the juvenile rat.


Bioassay of prolactin. Analysis of the pigeon crop-sac response to systemic prolactin injection by an improved method of response quantification.


Oestrogen binding sites in the chicken oviduct similar to those of the mouse uterus.


Epidemiological studies in certain diseases of the fundus of the eye.


Mucus flow in the conjunctiva. Rate of migration of the mucous thread in the inferior conjunctival fornix towards the inner canthus.


Distribution of tritiated benzylpenicillin in the rabbit eye.


Ophthalmologic and orthoptic examinations of dyslectics.


Pseudoexfoliation of the lens capsule. II. Development of the exfoliation syndrome.


Relapsing polychondritis. Report of a case presenting multiple ocular complications.


Desferrioxamine B in the prevention of hemorrhagic glaucoma.


Complications following eye treatment with 90Sr applicator.


Excitation-inhibition anomalies of the extra-ocular muscles; electromyographic observations.


Protein content of normal human aqueous humour in vivo.


Corneal opacity in familial plasma cholesterol ester deficiency.


Reconstruction of the upper eyelid ad modum Cutler and Beard.


Peri-arteritis retinalis segmentalis.

Peri-arteritis retinalis segmentalis.


Employment of the ophthalmoscope in goniscopy of submerged eye.


Leber's disease. 3.

Leber's disease. 3.


Development of the human foetal vitreous body. I. Biochemical changes.


Glaucoma, miotic therapy and cataract. IV. Chronic simple glaucoma and cataract formation.


The treatment of retinoblastomas with a 60Co application.


Ocular injury from CO2 laser irradiation.


Renal response of premature infants to milk formulas of different acid and protein contents.


Study of the gastric lipase activity in infants by determination of the glycerol content using an enzymatic method.


Nursing shortage and education.

Nursing shortage and education.


Epidemiological study of multiple sclerosis in western Poland.


Factors influencing the in vitro uptake of mercury vapour in blood.


The surface structure of mouse peritoneal cells--a study with the scanning electron microscope.


Light-microscopic radioautography utilizing araldite sections.


Fourier images in electron microscopy and their possible misinterpretation.


The possibilities of x-ray holographic microscopy.


Birefringence phenomena in cylindrical fibres.


A simplified time-lapse cinemicrographic unit.


Detection of dichroism with the microscope.


Low-contrast development of electron micrographs.


The structure and formation of the egg membranes in Nasonia vitripennis (Walker) (Hymenoptera, Pteromalidae).


Food poisoning caused by carbophenothion.


The medical curriculum and human values. Panel discussion.


Human values and curriculum design. A view for the future.


Human values and the medical curriculum. An educator's response.


The treatment of Paget's disease of bone. Hobson's choice?


Sudden unexpected death.

Sudden unexpected death.


New approaches in the treatment of parkinsonism.


Therapeutic uses of digoxin antibody.

Therapeutic uses of digoxin antibody.


Epidemiology and cytogenetics of conjoined TWINS.


Hemopericardium with use of oral anticoagulant therapy.


Arteriography and abdominal aortic aneurysm.


Occlusion of the dorsalis pedis artery in two young women.


Fuseli's nightmare.

Fuseli's nightmare.


Phytobezoar in an addict: the cotton-picking stomach syndrome.


Fetal suicide.

Fetal suicide.


Lactase deficiency.

Lactase deficiency.


The fine structure of lymphosarcoma in cattle.


Starting point of carcinoma of the cervix.


Lymph node chromography as an aid to pelvic lymphadenectomy.


Stereology, or the quantitative evaluation of microstructures.


Measurements from electron micrographs of organelle size in relation to their shape: a refinement applied to the epidermal melanosome and basal lamella.


A simple microtome capable of cutting sections of plastic-embedded material down to 1 um in thickness.


A clamp to hold electron-microscope grids for shadowing.


The refractive index and dry mass distribution of mammalian erythrocytes.


Visualization of substructure in ferritin molecules: an artifact.


Refractive-index measurements on birefringement by interference microscopy.


Artificial feeding: a new concept. The 'ready-to-feed' approach.


Retinal photography in the newborn.

Retinal photography in the newborn.


Studies on positional specificity of the castor bean acid lipase.


Effect of oestradiol benzoate on corpora lutea in rats bearing pituitary autografts.


The uptake of (6,7-3H) 17beta-oestradiol by tissues of the domestic fowl.


Approximate versus exact evaluation of bioassays based on quantal response.


Studies on the metabolism of corticosteroids in the human foeto-placental unit. 2. Corticosterone metabolism in previable foetuses.


A quantitative study of spermatogenesis in rats bearing hypothalamic lesions of mammillary and supra-chiasmatic nuclei.


The effect of heparin on sodium conservation and on the plasma concentration, the metabolic clearance and the secretion and excretion rates of aldosterone in normal subjects.


Effect of large doses of radioiodine on thyroid function. 3. The iodoproteins of the thyroid gland.


Effect of large doses of radioiodine on thyroid function. IV. Iodoproteins in blood.


Effect of testosterone propionate on the distribution of radioactive iodide in recently thyroidectomized rats.


Evaluation of the double antibody radioimmunoassay of insulin and the determination of insulin in plasma and urine in normal subjects.


The metabolism of radioactive L-5' isopropyl-3',3,5 triiodothyronine and its relation to thyroid hormone action.


The treatment of chronic liver diseases by means of an extralysate of liver.


The combined effect of isprenaline and paired electrical stimulation upon the heart activity in the dog.


Synthesis and pharmacology of a new potential anti-inflammatory drug, 1-(3',4'-methylenedioxybenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid (ID-955).


Anabolic androgenic steroids in the treatment of acquired aplastic anemia.


The origin, course and distribution of arteries to the thumb, with special reference to the so-called A. princeps pollicis.


Clinical investigations in the treatment of meningeal leukemia: radiation therapy regimens vs. conventional intrathecal methotrexate.


Electron microscopic histochemistry of xanthine oxidase: distribution pattern in the small intestine.


Hand volume and skin thickness in a normal population and in acromegaly.


In vitro studies of the release mechanism for vasopressin in rats. 3. Effect of metabolic inhibitors on the release.


Half-life of oxytocin in blood of pregnant and non-pregnant women.


Uptake of oxytocin in tissues after intravenous administration of tritiated oxytocin in rats.


Effect of polydiethylstilboestrol phosphate on the pituitary content of FSH and ICSH in male rats.


The relative effects of cortisone and triamcinolone (9alpha-fluoro-16alpha-hydroxyprednisolone) on the urinary excretion of trsin inhibitor in man.


3H-Corticosterone metabolism in the rat.


Contraception by an injectable, long-acting oestrogen-progestogen agent.


Divergent responses of arteriosclerotic and non-arteriosclerotic rats to a catabolic dose of cortisone.


Metabolism of 16alpha-hydroxy-pregnenolone and 17alpha-hydroxy-pregnenolone in the foeto-placental unit and mother at midgestation.


Binding of zinc to insulin and some insulin derivatives studied by paper electrophoresis.


A simple bioassay for detection of aflatoxin in milk.


The utilization of multiphasic screening in Public Health Centers.


Leber's retinal degeneration with miliary aneurysms.


Modification of cow's milk for infant formulas: current practices.


The unborn patient.

The unborn patient.


The value of the selenomethionine Se 75 scan in preoperative localization of parathyroid adenomas.


Determination of brain death by isotope angiography.


Psychiatry and the mysterious medical complaint.


Joint study of extracranial arterial occlusion. IV. A review of surgical considerations.


Peripelvic renal mass.

Peripelvic renal mass.


Methotrexate and psoriasis.

Methotrexate and psoriasis.


Vascular thievery.

Vascular thievery.


The expanding universal expander.

The expanding universal expander.


Taking the blood pressure.

Taking the blood pressure.


Lidocaine in the common bile duct. Effects and possible toxicity.


Complications of CVP catheter insertion in cubital vein.


Indian sandal strap dermatitis.

Indian sandal strap dermatitis.


Radiolucent foreign body demonstrated by sinogram.


Onychectomy.

Onychectomy.


Electron microscopic observations on the thyroid gland of the elasmobranchs.


On the problem of the development of the parafollicular cells from the human ultimobranchial body in prenatal life.


Lithium-induced thyroid disturbance: case report and review.


The risks of cardiac catheterization.

The risks of cardiac catheterization.


Shoe contact dermatitis.

Shoe contact dermatitis.


Epidemiologic features of 1,134 sudden, unexpected infant deaths. A study in the Greater Cleveland Area from 1956 to 1965.


Pneumothorax in cystic fibrosis.

Pneumothorax in cystic fibrosis.


Cerebral death and the electroencephalogram. Report of the ad hoc committee of the American Electroencephalographic Society on EEG Criteria for determination of cerebral death.


The misuse of pentazocine. Its dependence-producing potential.


Patient records in court: a hazard to psychotherapy.


Overseas medical aid.

Overseas medical aid.


Variability in little people.

Variability in little people.


Infectious mononucleosis presenting as urticaria.


Renal mass with hematuria.

Renal mass with hematuria.


False aneurysm after carotid endareterectomy.


Analysis of the central vasomotor effects of (-)-N-(1-phenylethyl)guanidine, a new adrenergic neuron blocking agent.


Studies on the pathologic physiology of pulmonary hypertension in mitral valvular disease. 1. The role of sympathetic nervous system on the increment of pulmonary vascular resistance.


Studies on the pathologic physiology of pulmonary hypertension in mitral valvular disease. 2. About the role of the pulmonary venous resistance.


Morphological studies on the autonomic nervous system of hypertensive rats. IV. Fluorescence microscopial observation on the superior cervical sympathetic ganglia of spontaneously hypertensive rats.


Morphological studies on the autonomic nervous system of hypertensive rats. V. Various morphological observations on the superior cervical sympathetic ganglia of rats with experimentally induced hypertension.


Myelocystographic and fluorescein studies to demonstrate communication between intramedullary cysts and the cerebrospinal fluid space.


Relapsed schizophrenics: more rapid improvement on a milk- and cereal-free diet.


Investigations on carbohydrate metabolism and vitamin C synthesis in biotin-deficient rats.


Treatment of extrathyroidal manifestations of Graves' disease.


The treatment of uraemic osteopathy.

The treatment of uraemic osteopathy.


Effect of cytostatics on the uterotrophic action of estrogens.


Influence of myelobromol on growth and metabolism of experimental tumours.


The pathogenesis of hyperthyroidism.

The pathogenesis of hyperthyroidism.


Treatment of lymph-node tumours with Vinblastin.


Orbital affection in nasal and paranasal neoplasms.


Epithelization of the anterior chamber. A clinical and histopathological study of a Danish material.


Endogenous uveitis. II. Recurrence rate.


Endogenous uveitis. 3. Antistreptococcal reactions (A.S.T. and A.S.H.).


Endogenous uveitis. I. Clinical aspects.


Incidence of subconjunctival cysticercosis.


The ultrastructure of the acini of the human lacrimal gland.


Evaluation of various vasoconstrictors in cataract surgery.


Distribution of tritiated tetracycline in the rabbit eye.


Goniodysgenesis and pigmentary glaucoma.


Renal vein thrombosis. A roentgenographic diagnosis.


Increased enteric formation of histamine in chronic pancreatitis.


Snowmobile injuries. Hazards from a popular new winter sport.


Evidence that growth failure from maternal deprivation is secondary to undereating.


Multiple neuropathic joints, including the wrist, in a patient with diabetes mellitus.


Glossary of cardiologic terms related to physical diagnosis and history. 3. Anterior chest movements. The ventricles, the atria, and the great vessels.


A guide to the problem of photosensitivity.


Pneumothorax following induction of anesthesia.


At your own risk: the case against chiropractic.


Nature, nurture, and stature.

Nature, nurture, and stature.


Corticosteroids and adrenal function.

Corticosteroids and adrenal function.


Small-intestinal morphology in infectious hepatitis.


Salivary gland enlargement during induction of anesthesia.


Carcinoma of the mammary crease. A neglected clinical entity.


Mediastinal emphysema in diabetic coma.

Mediastinal emphysema in diabetic coma.


Narcolepsy and highway accidents.

Narcolepsy and highway accidents.


Hemolytic anemia and G-6-PD deficiency.

Hemolytic anemia and G-6-PD deficiency.


Flush-back treatment of stone impacted in urethra.


Fatal air embolism during insertion of CVP monitoring apparatus.


Computerogenic heart disease.

Computerogenic heart disease.


Recognition and management of airway obstruction.


Sensitized photo-oxidation of wool and silk by a triazinylstilbene.


NIH: agency and clients react to retrenchment.


Even before Seebohm.

Even before Seebohm.


Health visiting in the seventies.

Health visiting in the seventies.


The structural formula and crystal structure of the O-p-bromobenzoate derivative of batrachotoxinin A, C31H38NO6Br, a frog venom and steroidal alkaloid.


The crystal structure of digitoxigenin, C23H34O4.


The self-assessment test.

The self-assessment test.


[On the anticonvulsant properties of oxazepam. Experimental study on the cat].


Motivation.

Motivation.


Personal considerations from the AMA Rural Health Conference.


Congenital ectodermal dysplasia, anhidrotic, with palatal paralysis and associated chromosome abnormality. Case report.


Interaction patterns in disadvantaged families.


Primary lymphosarcoma of the parotid gland.


AMA recognition award for continuing education.


Hereditary pilonidal sinus.

Hereditary pilonidal sinus.


Clinical effects of hypnotics. II. An epidemiologic study.


Dialysis in diabetics. A review of 44 patients.


An evaluation of the internship experience in New Jersey hospitals (1966-1967). A venture in voluntary regional cooperation.


An unresolved problem for developing countries. Korea as exhibit A.


Evaluation of a new mumps vaccine. Mumps virus vaccine, live, attenuated (Mumpsvax).


Council on drugs. List No. 83. New names.


Gas gangrene complicating fracture of the tibia.


Surveillance of drug therapy.

Surveillance of drug therapy.


Risk to offspring of parents with congenital heart defects.


Visual acuity testing in preschool children.


Holmesian observation without deduction.


Preparation of the skin for lumbar puncture.


The cost of medical care.

The cost of medical care.


Isolation of a factor or factors with potent immunifacient properties from Ehrlich ascites carcinoma cells.


Results following the use of benzydamine in the treatment of burns.


Dropropizine (UCB 1967), an antitussive: oral toxicity study in pure-bred dogs.


The effect of 0.5 mg lynestrenol on the follicle stimulating hormone, luteinizing hormone, oestrogen and pregnanediol excretion during the menstrual cycle.


Studies on the irritating substance of Pinellia ternata Breitenbach (Araceae).


The effect of dipyridamole on irreversible platelet aggregation.


The hyperfunctioning thyroid nodule.

The hyperfunctioning thyroid nodule.


Comparison of two methods for measuring drug-induced neurotoxicity.


Psychiatric disability rating in transition.


The morphologic effects of oral contraceptive agents on the cervix.


Milk surveillance, February 1969.

Milk surveillance, February 1969.


Milk surveillance, March 1969.

Milk surveillance, March 1969.


Electron microscopic observation of the human thymus of the fetus and the newborn.


An autopsy case of bilateral cortical necrosis of the kidneys.


Colistin nephrotoxicity: report of a case with light and electron microscopic studies.


An autopsy case of primary osteomyelosclerosis in a 6-year-old girl.


Neuro-Behçet's syndrome: report of two autopsy cases.


The treatment of North American blastomycosis. Ten years' experience.


Baroreceptor function revealed by acute sinoaortic denervation in spontaneously hypertensive rats.


Myocardial revascularization: the immediate effects of internal mammary artery implantation of the ischemic myocardium.


A use of Adaline as an automatic method for interpretation of the electrocardiogram and the vectorcardiogram.


Second degree sinoatrial block with the Wenckebach phenomenon associated with nodal escape and second degree atrioventricular block and its conversion to regular sinus rhythm by sympathetic stimulation; report of a case.


Environmental surveillance around a nuclear fuel reprocessing installation, 1965-1967.


Milk surveillance, April 1969.

Milk surveillance, April 1969.


Milk surveillance, May 1969.

Milk surveillance, May 1969.


"Little Hans" and family dynamics.

"Little Hans" and family dynamics.


Protection of human rights in medical research.


Primary tumors of the duodenal bulb.

Primary tumors of the duodenal bulb.


Statistical analysis of multiple sclerosis and neuromyelitis optica based on autopsied cases in Jan.


Three cases of acute diffuse lymphocytic meningo-encephalitis.


Influences of different electrode positions on the human somatosensory evoked response.


n-Hexane polyneuropathy.

n-Hexane polyneuropathy.


Cardiac arrest during exercise training. Report of a successfully treated case attributed to preparedness.


Core curriculum in allied health education.


Career mobility in allied health education.


Surgical management of ventricular aneurysm.


Guidelines for admission of alcohol-dependent patients to general hospitals.


Development and growth of new allied health fields.


Jogging and coronary artery disease.

Jogging and coronary artery disease.


The jaundiced newborn.

The jaundiced newborn.


A vexed question.

A vexed question.


Cardiac complications while jogging.

Cardiac complications while jogging.


Intrathecal cold saline solution: a new approach to pain (evaluation).


Myiasis of the scalp from DERMATOBIA HOMINIS.


Clinical course in hemophilia.

Clinical course in hemophilia.


Propoxyphene dependence.

Propoxyphene dependence.


Failure to make diagnostic tests.

Failure to make diagnostic tests.


Experimentation in children. A reexamination of legal ethical principles.


Distribution of black physicians in the United States, 1967.


A paradoxical conditioning effect in the human pupil.


Effects of seasickness on error scores in mirror tracing.


New B.N.F.

New B.N.F.


Enterogenous cyst of the ampulla of Vater.


Influence of alcohol feeding and a choline deficiency on some enzymes of ammonia detoxification in the rat liver.


Ultrastructural aspects of the liver in the viral hepatitis.


Liver structure in patients with choledochoduodenostomy.


The clinical application of intraluminal esophageal manometry.


The lymphatic drainage in portal hypertension.


The treatment of acute leukaemia with cytosine arabinoside: biochemical and clinical findings.


The health of underground workers in a Ruhr coal-mine.


The classification of seronegative rheumatoid arthritis.


The prophylactic action of polyvinylpyridine N-oxide (P 204) in silicosis. An experimental study.


Therapeutic thrombolysis in the ninth week of pregnancy.


Urolithiasis: a comparative spectrophotometric, pathological and morphological study.


The effect of intravenous streptokinase on arterial stenosis in the limbs.


Treating the geriatric patient.

Treating the geriatric patient.


Gentamycin in surgical practice.

Gentamycin in surgical practice.


Augmentation mammaplasty.

Augmentation mammaplasty.


Pulmonary and pleural abnormalities in rheumatoid disease.


Oral cytology for the family physician.

Oral cytology for the family physician.


Clinical management of heart block.

Clinical management of heart block.


Bhanja virus: a new arbovirus from ticks Haemaphysalis intermedia Warburton and Nuttall, 1909, in Orissa, India.


Ganjam virus: a new arbovirus isolated from ticks Haemaphysalis intermedia Warburton and Nuttall, 1909 in Orissa, India.


Isolation of Kyasanur forest disease virus from the insectivorous bat, Rhinolophus rouxi and from Ornithodoros ticks.


6 Azauridine in smallpox.

6 Azauridine in smallpox.


Vibriocidal test and its parameters.

Vibriocidal test and its parameters.


Vibrio alcaligenes in acute diarrhoea simulating cholera.


Oral replacement of water and electrolyte losses in cholera.


A classification of cholera vibrios into biotypes and their value for epidemiological purposes.


Studies on Tagetes minuta: some pharmacological actions of the essential oil.


Effect of cold stress on epinephrine and norepinephrine contents in the rat heart.


Effect of some adrenergic receptor antagonists on aminophylline-induced ventricular arrhythmias in dogs anaesthetized with halothane in oxygen.


Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. The effect of 6 indigenous plants on early pregnancy in albino rats was tested by a screening procedure standardized in this laboratory.  Pe troleum ether, alcoholic, and aqueous extracts of each plant were tested for antifertilizing, antizygotic, blastocystotoxic, antiimplantation, and early abortifacient activity.  The aqueous extract of Ocimum sanctum Linn. leaves and alcoholic extract of Polygonum hydropiper Linn. roots showed encouraging results while the extracts of Abroma augusta Linn.  roots, Calotropis gigantea Linn.  flowers and leaves, Michaelia champaka Linn. unripe fruit, and Plumbago rosea Linn. roots did not show any antiimplantation activity.  None of the rats delivered to experimental rats showed evidence of teratogenicity up to the age of 1 month.


A biochemical approach to anti-atherosclerotic action of Commiphora-mukul: an Indian indigenous drug in Indian domestic pigs (Sus scrofa).


Metachromatic leucodystrophy (sulphatide lipidoses). Juvenile type: case report.


Studies on the lipids of plasma of rats infected with Plasmodium berghei.


Acute renal ischaemia and the effect of local hypothermia on the histological changes: an experimental study.


Isolated normothermic perfusion of kidney using extracorporeal circulation.


Morphological studies on the thymus. I. Thymus of the marsupial--Trichosurus vulpecula.


A longitudinal study of morbidity and mortality pattern of children under the age of five years in an urban community.


Food sources, dietary habits and nutrient intake of the Nicobarese of Great Nicobar.


Prediction of maximum breathing capacity in Gujarati male subjects.


Preliminary communication on the weights of the erythrocytes in health and in anemias.


Reversible malignant hypertension due to pheochromocytoma. A case report.


A case of sickle-cell thalassemia.

A case of sickle-cell thalassemia.


The Sixth National Conference of Indian Academy of Pediatrics held at Lucknow from 12th to 15th February, 1969. Inaugural speech.


Inaugural speech at the inauguration of the scientific session.


Acetylcholine depolarization of the dorsal root nerve terminals in the amphibian spinal cord.


Evidence for peripheral cholinergic components in thrist-induced water consumption.


Effects of cardiac glycosides on spontaneous efferent activity in vagus and sympathetic nerves of cats.


Pharmacological alteration of hyper-reactivity in rats with septal and hypothalamic lesions.


The diagnosis of carcinoma of the colon and rectum: a review of one hundred and eight cases.


Carbon monoxide intoxication in cigar smokers.


Effect of albumin, normal human serum and anion concentration on insulin antibody reaction.


A simple method for the early detection of the malignant hyperpyrexia of anaesthesia and hypothesis.


Experimental studies on aconitine-induced atrial fibrillation with microelectrodes.


The genesis of cardiac fibrillation as an abnormal electrical phenomenon of the cell.


Autoregulation of cardiac contraction in atrial fibrillation.


Atrioventricular conduction in atrial fibrillation.


The structural basis for excitation-contraction coupling in mammalian myocardial cells.


Acute myocardial injury produced by sympathomimetic amines.


Assisted circulation by external pressure variation.


Experimental studies on the effects of propranolol and phenozybenzamine on the electrocardiogram and coronary blood flow.


Clinical estimation of myocardial force development by timing the arterial sounds.


Conduction pathways of excitation in the right atrium of the rabbit under hyperpotassemia. A study with multiple microsuction electrodes.


Significance of myocardial ammonia metabolism in the failing heart.


Atrial pathology and the esophageal electrocardiogram.


The mode of production of the left ventricular third heart sound.


The application of photoplethysmography to the recording of Valsalva maneuver responses.


The diagnostic applications of cardiac ultrasonics.


A hormonal influence of the heart on the kidney.


Continuous telemetered electrocardiograms during syncope.


Cardiovascular lesions in rubella embryopathy with special emphasis on pulmonary arterial disease.


Radiologic and angiocardiographic aspects of ventricular septal defect associated with aortic insufficiency.


Propagation of cardiac murmurs along bones.


The double-chambered right ventricle. A report of five cases.


Splitting of the second heart sound in partial anomalous pulmonary venous connection with intact interatrial septum.


Studies of plasma renin activity in patients with hypertension.


Renin content of kidneys in various types of experimental hypertension in rats.


Cerebrovascular accidents and their prevention in hypertensive patients.


Comparison of the maximal endurance of cardiac pre- and postoperative patients and normals.


Sodium intake and blood pressure in Pacific populations.


Testing in hypertension.

Testing in hypertension.


The epidemiology of urinary infections in Hiroshima, Japan and their relation to blood pressure levels and chronic pyelonephritis.


Blood rheology as a factor in the pathogenesis of coronary heart disease.


Cholesterol distribution and turnover in obesity in man.


Syndromes of extracranial great arterial insufficiencies presented with various clinical signs and symptoms.


Relations between circulating blood and pathogenesis of atherosclerosis.


The electrocardioanalyzer.

The electrocardioanalyzer.


Studies on hyperlipidemia among Japanese.


Significance of maximal exercise ST responses in middle-aged Chinese men.


Serum lipids in hard and soft water communities.


Observations on physical characteristics in coronary heart disease. An analysis of 75 cases.


The etiological role of diabetes mellitus in cardiovascular disease.


Identifying coronary prone families by screening of school populations.


Transitory abnormal Q waves in patients with and without myocardial infarction.


Clinical and electrocardiographic responses to exercise in patients with coronary artery disease.


Evaluation of risk factors in coronary heart disease in Ceylon.


Clinical observation of anginal attacks.


Correlations of coronary angiography with metabolic and electrocardiographic studies.


Hemodynamic-angiocardiographic correlations in ischemic heart disease.


Emotional correlates of angina pectoris.


Myocardial function during beta-adrenergic blockade.


Proplapse of the posterior leaflet of the mitral valve.


Neuroleptanalgesia in the treatment of acute myocardial infarction.


Hemodynamic effects of lidocaine.

Hemodynamic effects of lidocaine.


Acute coronary care in a small hospital.


Strict modified fat diet in coronary heart disease. The problem of nonresponders.


Rehabilitation of men with ischemic heart disease.


Physical activity at work, lipopproteins and the incidence of angina pectoris, myocardial infarction and death due to ischemic heart disease.


Coronary care unit in Japan.

Coronary care unit in Japan.


Five years experience with the use of partial ileal bypass in the treatment of hypercholesterolemia and atherosclerosis.


Prevention of recurrent myocardial infarction by physical exercise.


A myocardial syndrome associated with ventricular arrhythmias.


Coronary care unit versus hospital mortality in acute myocardial infarction.


Long-term prognosis in patients resuscitated from cardiac arrest.


Hemodynamic studies in primary myocardial disease.


Cardiac changes in progressive muscular dystrophy. A hemodynamic study.


Follow-up study of myocardial infarction: its hemodynamics and myocardial gas metabolism.


The mechanism of the Wenckebach phenomenon.


Variables influencing the prognosis in atrioventricular block.


Follow-up of patients with implanted pacemakers.


Studies of lymph flow and changes in pulmonary structures as indexes of circulatory changes in experimental pulmonary edema.


A study of the pathogenesis of local intraventricular block and monophasic wave.


The sinus node in cor pulmonale.

The sinus node in cor pulmonale.


Sympathomimetic effects of scorpion venom on the cardio- vascular system.


The hemodynamic response to isoproterenol in massive acute pulmonary embolism.


Streptokinase in acute major pulmonary embolism.


Aortic valve replacement.

Aortic valve replacement.


Analysis of the cardiac surgery case load in South Australia 1949-1967.


Catecholamine excretion in scorpion sting.


Effect of exercise on hemodynamic parameters in mitral valvular disease. Evaluation and clinical significance.


Aortic valve replacement with homograft.


Long-term (1 to 4 years) results with heart valve prostheses (102 consecutive cases).


Experience with the Kay-Shiley disk valve.


The functional and surgical anatomy of the aortic valve.


Surgery for Marfan's syndrome.

Surgery for Marfan's syndrome.


Mechanisms of antibiotic action.

Mechanisms of antibiotic action.


A long-term follow-up study after transventricular mitral valvotomy.


Approaches to rational antibiotic usage.


Urinary tract infections presentations.

Urinary tract infections presentations.


Clinical experience with a new type of valve replacement: a cageless discoid type of prosthesis named SAM valve.


Antibiotics and the kidney with special reference to the aged.


Results of reconstructive surgery for mitral incompetence.


Multiple valve replacement.

Multiple valve replacement.


Computer analysis of electrocardiograms during monitoring.


Computer based monitoring of patients following cardiac surgery.


Human versus computer evaluation of electrocardiographic data in epidemiological studies.


The electrocardiogram in diphtheritic myocarditis.


Sickledex--a rapid sickle-cell screening test.


Regulatory mechanism of the oxygen transport system.


Fluoridated water, hemodialysis, and renal disease.


Bacta-uria.

Bacta-uria.


Mafenide (Sulfamylon) and other topical agents for severe burns.


Intravascular, interstitial and intracellular phase changes during acute furosemide or ethacrynic acid diuresis.


Betamethasone valerate ointment (Valisone).


Persistent irregular tachycardia in a successful athlete without impairment of performance.


Effect of physical training on nuerocirculatory asthenia.


Clinical findings and diagnostic procedures in herniated cervical and lumbar discs.


Cirrhosis of the liver in infants and children.


Metastatic adrenal gland carcinomatosis. Case reports.


Transformation of lymphocytes by streptolysin S as a test for rheumatic fever.


Failure to demonstrate uptake of 3H-testosterone by the hypothalamus of young rats.


The use of neuroleptanalgesia during alcohol injection for tic douloureux.


Treatment of some common household poisonings.


Depression.

Depression.


Idiopathic hemochromatosis: clinical and laboratory features in 33 patients.


Myotonia congenita (Thomsen's disease) in a Chinese family.


"Common cold" and housing conditions in Singapore.


Multicentricity and management of well differentiated carcinoma in the thyroid.


Biological predeterminism.

Biological predeterminism.


Restless legs (Ekbom) syndrome.

Restless legs (Ekbom) syndrome.


The problem of death.

The problem of death.


Noradrenaline in infusion solutions.

Noradrenaline in infusion solutions.


Rheumatoid arthritis and respiratory disease.


Reversal of cervical myelopathy by adequate posterior decompression.


Viral hepatitis with haemolytic anaemia due to glucose-6-phosphate dehydrogenase deficiency.


Recent trend of deaths from unnatural causes (accidents, suicides and homicides) in Singapore, 1961-1965.


Benign thoracic cysts and tumours found in West Malaysian patients.


Treatment of the near-drowning victim.

Treatment of the near-drowning victim.


A review of burns in Singapore.

A review of burns in Singapore.


Intralobar pulmonary sequestration: diagnosis and surgical treatment, with a report of seven cases.


Mental health services in higher education: a Texas survey.


Hemorrhoidectomy by the submucosal resection technique.


Acute histiocytic medullary reticulosis in a pubescent girl.


Management of chronic renal failure by salt balancing.


Clinicopathologic conference.

Clinicopathologic conference.


Transport of peroxidase by the developing rat choroid plexus.


Studies on epidemiological, clinical and etiological aspects of multiple sclerosis.


Failure to thrive and fatal injury as a continuum.


Communication--is this the art of medicine?


H-type tracheo-esophageal fistula. Diagnostic and operative management.


Reinfection in enterobiasis (pinworm infection). Simultaneous treatment of family members.


Persistent mild hyperphenylalaninemia in various ethnic groups in Israel.


Seasonal incidence of hypertonic dehydration in diarrhea of infants. Experience in Buffalo from 1954 to 1967.


Cockayne's syndrome. Report of case with necropsy findings.


Picture of the month. Potter's syndrome.


Radiological case of the month. Absence of pectoralis major muscle.


Kleeblattschädel syndrome.

Kleeblattschädel syndrome.


Tricho-rhino-phalangeal syndrome.

Tricho-rhino-phalangeal syndrome.


Oculodentodigital dysplasia.

Oculodentodigital dysplasia.


Sickle cell disease and acute glomerulonephritis.


Klebsiella osteomyelitis in a newborn.

Klebsiella osteomyelitis in a newborn.


Right cervical aortic arch with left descending aorta. Case report and review of the literature.


Pulmonary edema as a complication of intracranial disease.


Postmortem diagnosis of metabolic disorders. The finding of maple syrup urine disease in a case of sudden and unexpected death in infancy.


Torsion of the appendix testis in the newborn. Initial report of this disorder in a neonate.


Acute renal failure in the neonate managed by peritoneal dialysis. Preliminary report of two cases.


Battered child syndrome at the Los Angeles Count General Hospital.


Unusual appearing child.

Unusual appearing child.


Hypoprothrombinemic bleeding in an infant.


Cranial vasculature of a neotropical fruit-eating bat, Artibeus lituratus.


Studies on the advent of ureotelism. The effects of bivalent cations on the capacity of the hepatic arginase of the Mexican axolotl to hydrolyse endogenous arginine. 1. The effects of 19 bivalent cations on the activity, stability and capacity to hydrolyse endogenous arginine of axolotl liver arginase were studied. 2. It was found that Fe(2+), Co(2+), Ni(2+) and Zn(2+), as well as Mn(2+), stabilize the enzyme and render it able to hydrolyse endogenous arginine. 3. By using different concentrations of Co(2+) and Ni(2+) it was possible to dissociate the effect of each of the metal ions on the activity and stability of arginase from that on its capacity to hydrolyse endogenous arginine. 4. The effects of Mn(2+), Co(2+) and Ni(2+) on the activity and stability of arginase in the homogenate were also observed with purer preparations of the enzyme. 5. It is suggested that the capacity to hydrolyse endogenous arginine is a consequence of the integration of arginase with the arginine-formation sites.


Intramitochondrial localization of delta-aminolaevulate synthetase and ferrochelatase in rat liver. Intramitochondrial loci for delta-aminolaevulate synthetase and ferrochelatase, the initial and final enzymes in haem synthesis, have been found in rat liver. Two different methods of fractionation were applied to mitochondria: (a) sonication and density-gradient centrifugation; (b) treatment with digitonin and differential centrifugation. Similar results were obtained with each technique. delta-Aminolaevulate synthetase is distributed similarly to two known matrix enzymes, malate dehydrogenase and glutamate dehydrogenase. Ferrochelatase is firmly bound to the the inner mitochondrial membrane. These results are considered in terms of the regulation of haem synthesis and in relation to mitochondrial biogenesis.


A purification and some properties of an insecticidal exotoxin from Bacillus thuringiensis Berliner. An insecticidal exotoxin from Bacillus thuringiensis var. thuringiensis (Berliner) has been purified. The efficiency of each stage of the purification has been ascertained and the yield of toxic material estimated by means of a quantitative bioassay. It is shown that the exotoxin is an adenine derivative substituted at position 9 and having a molecular weight of approximately 825. It can be dephosphorylated enzymically or chemically under conditions that define the exotoxin as a phosphomonoester. This results in loss of toxicity, both to insects and to mice. Spectroscopic and kinetic data are presented which suggest that a beta-ribofuranosyl moiety may be attached to the adenine. Glucose and allomucic acid have been positively identified as hydrolysis fragments from the exotoxin. These results are discussed and compared with the results of others on similar (or possibly identical) compounds.


Amino ketone synthesis in avian erythrocytes. 1. The relative rates of synthesis of aminolaevulate and aminoacetone by particles prepared from avian erythrocytes were measured under various conditions. 2. The production of both amino ketones by fresh particles was about three times greater in anaemia caused by phenylhydrazine and acetylphenylhydrazine than in anaemia caused by removal of 20-30ml. of blood. 3. The synthesis of aminolaevulate by freeze-dried particles decreased more than that of aminoacetone in the absence of added pyridoxal phosphate, in the presence of cyanide and of tris buffer, and after preincubation of the erythrocyte particles. Other differences in the rates of synthesis of the two amino ketones were observed after (a) incubation of particles at different temperatures and (b) storage of homogenized freeze-dried particles at different pH values. 4. It is suggested that these differences in the production of the two amino ketones are due to the presence of two amino ketone synthetases or to two or more isoenzymes of aminolaevulate synthetase. 5. The metabolic significance of aminoacetone in erythrocytes is discussed.


The induction of cross-links in soluble rat skin collagen in vitro. 1. Starch-gel electrophoresis was used to investigate the subunit composition of salt-soluble and acid-soluble rat skin collagen. 2. Cross-linkage of collagen subunits in vitro was performed (a) when in fibrillar form and (b) when in solution. In the former case the increase in number of cross-links appeared to be predominantly intermolecular and in the latter case predominantly intramolecular.


Control of the citric acid cycle by glyoxylate. The mechanism of inhibition of oxoglutarate dehydrogenase, isocitrate dehydrogenase and aconitate hydratase. 1. The effects of glyoxylate on partially purified preparations of aconitate hydratase, isocitrate dehydrogenase and oxoglutarate dehydrogenase were compared with those of oxalomalate and hydroxyoxoglutarate (obtained by condensation of glyoxylate with oxaloacetate and pyruvate respectively). 2. Glyoxylate (1mm) did not affect aconitate hydratase and isocitrate dehydrogenase, whereas oxalomalate (1mm) inhibited the enzyme activities completely. 3. Glyoxylate (0.025mm) inhibited oxoglutarate dehydrogenase irreversibly, whereas the same concentrations of oxalomalate and hydroxyoxoglutarate were ineffective. This inhibitory effect was prevented if oxoglutarate, pyruvate or oxaloacetate was mixed with the enzyme before the glyoxylate. 4. Incubation of oxoglutarate dehydrogenase with radioactive glyoxylate produced radioactive carbon dioxide; radioactivity was also recovered in the portion of the enzyme identified with thiamin pyrophosphate. 5. The behaviour of glyoxylate in producing multiple inhibitions of the citric acid cycle, either by direct interaction with oxoglutarate dehydrogenase, or by means of its condensation compounds which inhibit aconitate hydratase and isocitrate dehydrogenase, is discussed.


Substituent effect on lysozyme-catalysed hydrolysis of some beta-aryl di-N-acetylchitobiosides. Measurements are reported on the kinetics of the lysozyme-catalysed hydrolysis of several beta-aryl di-N-acetylchitobiosides, some of which have been synthesized for the first time. The catalytic rate constants (k(cat.)) at 45 degrees yield a curved Hammett plot (concave up) and the plot of DeltaH(double dagger) versus DeltaS(double dagger) has a sharp break. Substrates with electron-withdrawing groups exhibit a kinetic deuterium isotope effect (k(H) (cat.)/k(D) (cat.)), whereas those with electron-donating groups show no such isotope effect. The results suggest the operation of different mechanisms for the two types of substrates.


A comparison of the effects of ultraviolet and ionizing radiations on trypsin activity and on its constituent amino acids. Photons of 254nm. u.v. light, (60)Co gamma-rays and 1Mev electrons produce different patterns of destruction of individual amino acids in dried films of trypsin and in the corresponding amino acid mixture. For example, in the amino acid mixture u.v. light destroys tyrosine, tryptophan and cystine, whereas in trypsin only cystine is disrupted but with 10 times the initial yield. Further, in the amino acid mixture loss of half-cystine is a simple exponential function of dose, but in trypsin there appear to be two exponential components of the loss with yields that differ by a factor of 35. Both the gamma-rays and electrons destroy half-cystine, tryptophan, histidine and methionine in the amino acid mixture with remarkably high yields, whereas in trypsin doses that destroy almost all of the enzymic activity produce no detectable destruction of amino acid residues. These marked differences between the two preparations show that the radiation-sensitivity of a given amino acid alone and in a protein is different, and suggests that in trypsin there is fairly extensive migration of energy, charge or both with localization of damage at specific sites determined by this enzyme's internal organization. All three types of radiation produce appreciable amounts of ;damaged' (not completely inactivated) molecules which are prevented from reassuming an active configuration by the addition of 5.5m-urea; thiol reagents have a similar effect after bombardment with u.v. light or electrons. The patterns of destruction produced by gamma-rays and by electrons in both the amino acid mixture and in trypsin are different (some of the yields vary by a factor of 30). This result appears to be inconsistent with the popular belief that most of the energy absorbed from gamma-rays is associated with very-high-energy electrons.


The interpretation of kinetic data for enzyme-catalysed reactions involving three substrates. The analysis and interpretation of initial-rate data for reactions involving three substrates, obtained in suitably designed experiments, are discussed. Possible mechanisms for such reactions are classified, the rate equations are compared and the extent to which they can be distinguished experimentally is considered.


The glucan components of the cell wall of baker's yeast (Saccharomyces cerevisiae) considered in relation to its ultrastructure. 1. Commercial pressed baker's yeast, and cell walls prepared from it, were extracted in various ways and the products examined by a number of techniques, including infrared spectroscopy and electron microscopy. 2. The glucan components of the walls cannot be extracted from intact yeast cells by 3% (w/v) sodium hydroxide at 75 degrees , but at least one-third of the glucan of cell wall preparations is dissolved under these conditions, and more will dissolve after ultrasonic treatment. 3. If intact cells are given a preliminary treatment with acid the wall glucans dissolve in dilute aqueous alkali. 4. Acid conditions as mild as sodium acetate buffer, pH5.0, for 3hr. at 75 degrees are sufficient for this preliminary treatment; the glucan then dissolves in 3% sodium hydroxide at 75 degrees leaving a very small residue, which contains chitin and about 1% of the initial glucan of the wall. Dissolution is hindered by exclusion of air, or by a preliminary reduction with sodium borohydride, suggesting that some degradation of the glucan by alkali is taking place. 5. After treatment with 0.5m-acetic acid for 24hr. at 90 degrees the glucan dissolves slowly at room temperature in 3% sodium hydroxide, or in dimethyl sulphoxide. The extraction with acetic acid removes glycogen and a predominantly beta-(1-->6)-linked glucan (not hitherto recognized as a component of baker's yeast), but none of the beta-(1-->3)-glucan, which remains water-insoluble. 6. Without treatment with acid, the glucan is not significantly soluble in dimethyl sulphoxide, but can be induced to dissolve by ultrasonic treatment. 7. These results are interpreted by postulating the presence of an enclosing membrane, composed of chitin and glucan, that when intact acts as a semipermeable membrane preventing the escape of the alkali- and dimethyl sulphoxide-soluble fraction of the glucan. Mild acid treatments damage this membrane, and ultrasonic and ballistic disintegration disrupt it. 8. Some support for this hypothesis is given by the effects of certain enzyme preparations, which have been found to render a substantial part of the glucan extractable by dimethyl sulphoxide.


Structural requirements for active intestinal transport. Spatial and bonding requirements at C-3 of the sugar. Analogues of d-glucose modified at C-3, and in some cases at a second position, were prepared and tested for active accumulation by everted segments of hamster intestine. Their relative affinity for the sugar carrier was measured by tissue/medium ratio, Michaelis-Menten kinetics and competitive inhibition of d-galactose or methyl alpha-d-glucoside transport. d-Glucose and its 3-deoxy-3-fluoro, 3-chloro-3-deoxy and to a smaller extent its 3-bromo-3-deoxy derivatives, bound and were transported more strongly than 3-deoxy-d-glucose and other sugars not containing an electronegative atom in the gluco configuration at C-3. 3-Deoxy-d-galactose, 3,6-dideoxy-d-glucose and d-gulose, which have two alterations from the d-glucose structure, were not, or only very weakly, transported. The results are interpreted as indicating the presence of a hydrogen bond from the carrier to the hydroxyl group at C-3 of d-glucose. Spatial requirements are also discussed. New syntheses are reported for 3-chloro-3-deoxy- and 3-bromo-3-deoxy-d-glucose and 3,6-dideoxy-d-glucose.


Incorporation of [14C] histidine into homocarnosine and carnosine of  frog brain in vivo and in vitro. 1. Homocarnosine, carnosine and histidine were determined in brain from several species and the results compared with values in the literature. 2. [(14)C]Homocarnosine and [(14)C]carnosine were isolated from frog brain after intracerebral injection of [(14)C]histidine in vivo. 3. Whole frog brain, incubated in vitro with l-[(14)C]histidine, formed labelled homocarnosine and carnosine. 4. A frog brain homogenate or supernatant fraction catalysed the incorporation of l-[(14)C]histidine into homocarnosine and carnosine. 5. The results indicate that brain tissue can synthesize homocarnosine and carnosine.


The kinetic properties of citrate synthase from rat liver mitochondria. 1. Citrate synthase (EC 4.1.3.7) was purified 750-fold from rat liver. 2. Measurements of the Michaelis constants for the substrates of citrate synthase gave values of 16mum for acetyl-CoA and 2mum for oxaloacetate. Each value is independent of the concentration of the other substrate. 3. The inhibition of citrate synthase by ATP, ADP and AMP is competitive with respect to acetyl-CoA. With respect to oxaloacetate the inhibition by AMP is competitive, but the inhibition by ADP and ATP is mixed, being partially competitive. 4. At low concentrations of both substrates the inhibition by ATP is sigmoidal and a Hill plot exhibits a slope of 2.5. 5. The pH optimum of the enzyme is 8.7, and is not significantly affected by ATP. 6. Mg(2+) inhibits citrate synthase slightly, but relieves the inhibition caused by ATP in a complex manner. 7. At constant total adenine nucleotide concentration made up of various proportions of ATP, ADP and AMP, the activity of citrate synthase is governed by the concentration of the sum of the energy-rich phosphate bonds of ADP and ATP. 8. The sedimentation coefficient of the enzyme, as measured by activity sedimentation, is 6.3s, equivalent to molecular weight 95000.


Characteristics of beta-galactosidase in the mucosa of the small intestine of infant rats. Physicochemical properties. 1. The characteristics of acid and neutral beta-galactosidases isolated chromatographically from homogenates of the mucosa of the jejunum and ileum of suckling rats were studied. 2. The minimal molecular weight of the acid beta-galactosidase, as estimated by gel filtration on Sephadex G-200, was in the range 83000-105000, whereas for the neutral beta-galactosidase the estimated molecular weight was in the range 360000-510000. 3. The acid and neutral beta-galactosidases were inhibited competitively by galactono-(1-->4)-lactone, with respective K(i) values of 0.15mm and 1.1mm. Only the acid beta-galactosidase was inhibited competitively by sodium galactonate (K(i) 0.17mm). 4. Heat inactivation of both beta-galactosidases occurred according to first-order kinetics. The neutral enzyme was more labile, but bovine serum albumin protected acid enzyme only. 5. Urea treatment inactivated both beta-galactosidases, the neutral beta-galactosidase being more sensitive than the acid beta-galactosidase. 6. No differences were found between preparations from the jejunum and ileum.


Spectrophotometric determination of pyridoxal and pyridoxal 5'-phosphate with 3-methyl-2-benzothiazolone hydrazone hydrochloride, and their selective assay. A spectrophotometric method with 3-methyl-2-benzothiazolone hydrazone hydrochloride was developed for the determination of pyridoxal and pyridoxal 5'-phosphate, and for the selective determination of each in the presence of the other. Pyridoxal and pyridoxal 5'-phosphate react with the reagent to yield the azine derivatives, which give characteristic absorption spectra. The highest extinction values are obtained when pyridoxal and pyridoxal 5'-phosphate are incubated at pH values of about 3.4 and 8.0 respectively; their maxima are at 430nm. (in 2.74x10(4)) and 380nm. (in 2.24x10(4)) respectively. The azine of pyridoxal is only slightly soluble under the neutral and alkaline conditions, whereas that of pyridoxal 5'-phosphate is substantially insoluble in the acid pH range. This difference in solubility of the azines made possible the selective determination of pyridoxal and pyridoxal 5'-phosphate. alpha-Oxoglutarate and pyruvate are among the substances shown not to interfere with the assay of pyridoxal; their derivatives absorb appreciably only at wavelengths below 420nm. For the assay of pyridoxal 5'-phosphate in the presence of these compounds measurement at 390nm. is necessary.


The catabolism of plasma glycoproteins in normal and injured rats. The catabolism of (14)C-labelled plasma glycoprotein in rats was studied after injecting homologous plasma protein labelled in the N-acetylglucosamine and sialic acid moieties. In normal animals the catabolism was approximately described by a four-compartment model. The fractional rate of catabolism of the plasma-protein amino sugar was found to be 0.0305hr.(-1), corresponding to the degradation of 2.75mumoles/hr. The (14)C label was eliminated from the animals largely as carbon dioxide with a small proportion appearing in the urine. Freely circulating amino sugars or glycopeptides did not appear in the plasma as a result of the catabolic processes, and there was no evidence that the protein-bound amino sugars were reutilized in biosynthetic processes. A study of the distribution of (14)C label in the carcasses of animals 24hr. after injection provided evidence that the gastrointestinal tract accounted for 25-38% of the total catabolic pool; the lungs, kidneys, spleen and liver also appeared to contribute to catabolism. Studies were conducted with rats that had been treated with turpentine to induce an inflammatory reaction; the results could not be analysed kinetically, since the metabolism of plasma proteins in these animals did not appear to be in a steady state. The injected plasma protein disappeared from the intravascular pool more quickly than in normal animals, but there were no significant differences in the rates of excretion of the (14)C label.


Saturated hydrocarbons in bovine liver.

Saturated hydrocarbons in bovine liver. A homologous series of n-alkanes (C(14)-C(33)) and two isoprenoid hydrocarbons, 2,6,10,14-tetramethylhexadecane (phytane) and 2,6,10,14-tetramethylpentadecane (pristane) have been identified in bovine liver. Another branched but non-isoprenoid alkane and three isomers of molecular formula C(20)H(40) were partially identified. Phytane and the C(18)-C(22) and C(29)-C(33)n-alkanes were found to be the major components in liver, suggesting that at least the main hydrocarbon components were derived from various plants in the diet. The hydrocarbons were separated and identified by a series of steps involving solvent extraction, saponification, elution chromatography on alumina and silica gel columns, molecular sieving and by infrared and ultraviolet spectroscopy, followed by combined capillary gas chromatography-mass spectrometry.


Effect of an intrauterine thread on acid cathepsin activity in the endometrium of the pseudopregnant rat.


The direct determination of amino acids on thin-layer chromatograms by densitometry.


Effect of some inhibitors of platelet aggregation on platelet nucleotides.


Conformational states of native and denatured phosphoglucose isomerase. I. Titration of exposed and burie amino acid residues.


Conformational states of native and denatured phosphoglucose isomerase. II. Ultraviolet difference spectroscopy.


The glycoprotein structure of yeast invertase.


Restricted reactivity of the epsilon-amino groups of tobacco mosaic virus protein toward trinitrobenzenesulfonic acid.


Oligonucleotide interactions. II. Differences in base stacking in linear and cyclic deoxythymidine oligonucleotides.


The optically active heme bands of hemoglobin and methemoglobin derivatives. Correlation with absorption and magnetic properties.


Characterization of the alpha-chains of chick skin collagen and the nature of the NH2-terminal cross-link region.


Characterization of rat heart myosin. I. Isolation and physical properties.


Physical studies of hemocyanins. IV. Oxygen-linked disassociation of Loligo pealei hemocyanin.


The enzymatic steps of pyrimidine biosynthesis in the unfertilized frog egg.


Unusual difference spectra of proteins containing tryptophan. I. Studies with model compounds.


Subunit interaction and enzymatic activity of mouse 7S nerve growth factor.


The ribosomal subunit--polyribosome cycle in protein synthesis of embryonic skeletal muscle.


Structural requirements for binding of bradykinin to antibody. 3. The effect of carrier on antibody specificity.


Dissociation-produced loss of regulatory control of homoserine dehydrogenase of Rhodospirillum rubrum. I. Factors which affect the interconversion of the regulatable and nonregulatable states.


Dissociation-produced loss of regulatory control of homoserine dehydrogenase of Rhodospirillum rubrum. II. Some properties of the regulatable and nonregulatable forms.


Partial characterization of presumptive myosin messenger ribonucleic acid.


Polyriboadenylic and polydeoxyriboadenylic acids. Optical rotatory studies of pH-dependent conformations and their relative stability.


The isolation of cod muscle tropomyosin by heat treatment.


Characterization of monomers and small assemblies of tobacco mosaic virus proteins using the electric birefringence method.


Conformational changes during reversible depolymerization of the protein coat from bacteriophage.


Circular dichroism studies on the reversible depolymerization of tobacco mosaic virus protein.


Sedimentation studies on catalase Complex II using photoelectric scanning optics.


A method for the isolation of antibodies to human beta 1-lipoprotein.


The effect of denaturing agents on the molecular weight of bovine alpha-crystallin.


The isolation and analysis of a glycoprotein from parotid saliva.


The kinetic measurement of the alpha-beta dissociation of glutamate dehydrogenase.


Stereochemical studies of cyclic peptides. VI. Energy calculations of the cyclic disulphide cysteinyl-cysteine.


Purification of human factor X and comparison of peptide maps of human factor X and prothrombin.


The isolation and purification of a macromolecular protein component from the human erythrocyte ghost.


Hemoglobin G Szuhu: beta80 Asn replaced by Lys.


The amino acid sequence of cobrotoxin.

The amino acid sequence of cobrotoxin.


The distribution of the long-acting thyroid stimulator among gamma G-immunoglobulins.


The lamphbrush chromosomes of Salamandra salamandra (L.) (Amphibia Urodela).


Karyotypes of four passerine birds belonging to the families Turdidae, Mimidae, and Corvidae.


The capacity of the fourth chromosome of Drosophila melanogaster to establish end-to-end contacts with the other chromosomes in salivary-gland cells.


Fine structural studies of apolar mitosis.


Interaction of chromatid breaks induced by nitrosoguanidine in combination with some radiomimetics and x-rays.


Supernumerary chromosomes of the Harvest mouse, Reithrodontomys megalotis.


Mitotic instability leading to an accumulation of B-chromosomes in grasshoppers.


Patterns of puffing activity in the salivary gland chromosomes of Drosophila. II. The X-chromosome puffing patterns of D. melanogaster and D. simulans.


Patterns of puffing activity in the salivary gland chromosomes of Drosophila. 3. A comparison of the autosomal puffing patterns of the sibling species D. melanogaster and D. simulans.


A karyological study of three species of Scincidae (Reptilia).


Some cytologic aspects of meiosis in female guinea pig.


Kinetics of aspartate aminotransferase from wheat germ.


Effects of treatment with dithiothreitol on the extraction, activity and purification of ox-kidney urate oxidase.


D-Aspartate oxidase from pig kidney. 8. Oxygen and ferricyanide as acceptors.


Some properties of the phenylalanyl tRNA synthetase-activity from wheat seedling chloroplasts.


The EEG in dystrophia myotonica.

The EEG in dystrophia myotonica.


Prediction of the course of continuous fermentation on the basis of analysis of the batch process.


Anomalous uptake of D-ribose by Rhodotorula gracilis.


Anaerobic decomposition of glucose continuously added to the soil.


Cultivation of the yeast Candida lipolytica on hydrocarbon. 3. Oxidation and utilization of individual pure hydrocarbons.


Passive administration of antibodies during the primary immunization. The influence on the secondary response.


Metabolical and morphological events in isolated lung alveolar cell populations making antibodies.


Genetic control of the immune response. I. Differences in immune response of inbred strains of mice to p-aminobenzoic acid and sulphanilic acid.


Antifungal antibiotic of the basidiomycete Oudemansiella mucida. I. Isolation and cultivation of a producing strain.


Metabolites of Streptomyces noursei. X. Biogenesis of cycloheximide.


Regulation of biosynthesis of secondary metabolites. IV. Purification and properties of phosphoenolpyruvate carboxylase in Streptomyces aureofaciens.


Biogenesis of streptimidone.

Biogenesis of streptimidone.


Corticosteroid arthropathy and tendon rupture.


Dysmelia. A classification and a pattern of malformation in a group of congenital defects of the limbs.


Occipito-cervical fusion. An operative technique and its indications.


Orthopaedic aspects of the Ehlers-Danlos syndrome.


Subacute haematogenous osteomyelitis.

Subacute haematogenous osteomyelitis.


Osteomyelitis of the metatarsal sesamoids.


Compression of the deep palmar branch of the ulnar nerve. Case report and anatomical study.


The clinical significance of the extensor digitorum brevis manus.


Locking of the metacarpo-phalangeal joint from a loose body. Report of a case.


Syme's amputation. A review of sixty-seven cases.


A review of long-term results of arthrodesis of the first metatarso-phalangeal joint.


Avulsion fractures of the calcaneus.

Avulsion fractures of the calcaneus.


Disorganisation of the knees following intra-articular hydrocortisone injections.


Post-operative aneurysm of the descending genicular artery presenting as a pulsating haemarthrosis of the knee.


Rupture of patellar ligament after steroid infiltration. Report of a case.


Major arterial injury in closed fracture of the neck of the humerus. Report of a case.


Surface ultrastructure of mature adult human articular cartilage.


Bone structure in osteomalacia, with special reference to ultrastructure.


The structure of the vertebral spongiosa.


Consequences of avascular necrosis of the femoral head in rabbits. A histological and radiological study.


NMR subspectral analysis applied to polyfluorobenzenes C-6-H-n-F-6-n. IV. 1,2,4-trifluorobenzene.


Internal-rotational spectra of methylamines. II. The fundamental torsional band of CH2DNH2.


Epidemiological survey of diabetes in Toowoomba, Queensland.


Coronary disease in mining communities in Marion County, West Virginia.


Family patterns of medical care utilization. Possible influences of family size, role and social class on illness behavior.


Preparation of the student for education abroad.


The geography of reprint requests.

The geography of reprint requests.


A team approach to learning community health.


Some theoretical issues in professional socialization.


Computer-assisted instruction in continuing medical education.


Student participation in curriculum planning and evaluation.


Activism through the Student American Medical Association.


Approaches to the teaching of physical diagnosis.


Physicians' attitudes of omnipotence in a University Hospital.


Dogmatism and attitude differences in medical students.


The medical knowledge self-assessment program.


Medical education in Tropical Africa.

Medical education in Tropical Africa.


Conference on increasing representation in medical schools of Afro-Americans, Mexican-Americans, and American Indians.


Undergraduate origins of medical students.


The role of the university in graduate medical education. Forward.


The role of the university in graduate medical education. Introduction.


Graduate medical education revisited.

Graduate medical education revisited.


The role of the university in graduate training.


A university's response to demands for care: community medicine at Kentucky.


Financing graduate medical education.

Financing graduate medical education.


A critique of graduate medical education in community hospitals.


Orthopaedics and the impact of learning theory.


Neurological surgery and the assessment of accomplishment.


Pediatrics: the relation of training to multiple tracks of the future.


Patterns of training for internal medicine.


Physiology.

Physiology.


Basic science input into training: its nature and content. Panel presentation.


The evolutionary functions of American medical specialty boards.


The role of the university in graduate medical education. Proceedings of the Conference Council of Academic Societies. October 2-5, 1968. Washington, D. C. Discussion group report.


The role of the university in graduate medical education. Summary and conclusions.


The role of the university in graduate medical education. 4. Orthopaedic certification examination.


The role of the university in graduate medical education. 2. Pediatric training programs.


The role of the university in graduate medical education. 3. Orthopaedic in-training examination.


National intern and resident matching program, 1969.


New mesostigmatid mites from Pakistan with keys to genera and species.


Tests with ixodicides for the control of the tick vectors of Kyasanur Forest Disease.


Culiseta Marchettei, a new species of the subgenus Climacura Howard, Dyar, and Knab from Malaysia, with notes on its biology (Diptera: Culicidae).


Daily flight activity of male Tabanus lineola var. Hinellus Philip (Diptera: Tabanidae) in the estuarine area of Louisiana.


Sugar solution feeding and its effect on the retention of infective Dirofilaria immitis larvae in Anopheles quadrimaculatus.


A new species and new record of chiggers from West Malaysia (Prostigmata: Trombiculidae).


Reaction of the winter tick, Dermacentor albipictus (Packard), to CO2.


Abundance of rodents and fleas as related to plague in Lava Beds National Monument, California.


Growth of the dog tick Dermacentor variabilis say (Acarina: ixodidae). I. Growth pattern.


Preliminary studies on Dermatophagoides farinae Hughes, 1961 (Acari) and house dust allergy.


The mosquitoes of the Dar-es-Salaam area, Tanzania, with special reference to Aedes (Stegomyia) species and the epidemiology of yellow fever.


Growth of the dog tick Dermacentor variabilis Say (Acarina: Ixodidae). II. The effect of starvation and host species on its growth and fecundity.


Japanese encephalitis virus in Taiwan: preliminary evidence for Culex annulus Theob. as a vector.


Wild turkey ectoparasites collected in the Southeastern United States.


The laboratory infection of Culex pipiens complex with Brugia pahangi.


Body composition in experimental intrauterine growth retardation in the rat.


Vitamin E deficiency and the accumulation of amino acids in skeletal muscle.


Effects of magnesium deficiency, dietary sulfate and thyroxine treatment on kidney calcification and tissue protein-bound carbohydrate in the rat.


Some observations on the stability of encephalitogenic basic proteins in solution.


Failure of men to select a balanced amino acid mixture.


Effect of protein deprivation of swine during all or part of gestation on birth weight, postnatal growth rate and nucleic acid content of brain and muscle of progeny.


Development of a multilingual aphasia battery. Progress and problems.


Effect of histidine and certain other amino acids on the absorption of iron-59 by rats.


Effect on nitrogen balance of adult man of varying source of nitrogen and level of calorie intake.


Pathology of muscular hypotonia in the Prader-Willi syndrome. Light and electron microscopic study.


Pyridoxine deficiency and iron metabolism in the pregnant rat: fetal responses.


Chromatic flicker.

Chromatic flicker.


Development of morphological changes in experimental tick-borne meningoencephalitis induced in white mice by different virus doses.


Comparison of increment and decrement thresholds near a light-dark boundary.


Effect of source of dietary nitrogen on plasma concentration and urinary excretion of amino acids of men.


Studies on the biosynthesis of TMV. I. A system approaching a synchronized virus synthesis in a tobacco leaf.


Microdissection in enzyme histochemistry of peripheral nerve.


Transient neurological manifestations in cardiac arrhythmias.


Studies on proteins of animal ribosomes. I. Separation of ribosomal proteins from rat liver by chromatography on CM-cellulose and properties of some protein components.


Studies on proteins of animal ribosomes. II. Separation of ribosomal proteins from rat liver by preparative polyacrylamide gel electrophoresis and some properties of the protein fractions.


A new class of arginine-requiring mutants in Chlamydomonas reinhardi.


Fusarium oxysporum and Aspergillus flavur spore germination in the rhizosphere of peanut.


Accumulation by plants of organochlorine insecticides from the soil.


Effects of ozone on growth, lipid metabolism, and sporulation of fungi.


Relating lipid content and fatty acid synthesis to ozone injury of tobacco leaves.


Stimulus control over operant galvanic skin responses.


Statistical distribution of volar skin potential level in attention and the effects of age.


Technical note: some view on the treatment of "artifacts" in psychophysiological recordings.


Cardiac activity during experimentally induced anxiety.


An evaluation of tetany produced by electric shock.


Avoidance conditioning of skin potential responses.


"Augmenting" and "reducing" in averaged visual evoked responses to sine wave light.


Autonomic responsivity and reaction time under fixed and variable signal schedules.


Intake-rejection, verbalization, and affect: effects on heart rate and skin conductance.


Manipulation of contrast between differential GSR responses through the use of ordered tasks of information detection.


Cortical evoked potentials to semantic stimuli.


Definitive operations for perforated duodenal ulcers.


Function of the isolated perfused pig liver.


The diatrizoate precipitation test for intestinal perforation.


Prognostic significance of tumor cells in the bone marrow.


Appendectomy during pregnancy.

Appendectomy during pregnancy.


Results in the management of head and neck cancer.


Microemboli during cardiopulmonary bypass detected by ultrasound.


Adrenal microcirculation in hemorrhagic shock.


Comprehensive selective angiography in cerebrovascular insufficiency.


Late complications of traumatic arteriovenous fistulas.


A method for assessing the circulation distal to a femoral artery obstruction.


Jejunoplasty for the correction of jejunal atresia.


Lactic dehydrogenase isozymes in vaginal pools of patients with pelvic malignant tumors.


Influence of hemorrhagic hypotension on measurements of the extracellular fluid volume.


Can gallstones be prevented?

Can gallstones be prevented?


The open wound.

The open wound.


Wound closure with double-run nylon.

Wound closure with double-run nylon.


Uterine aspiration in the management of incomplete abortion.


Arabinonucleotides 3. The conversion of cytidylic acid into aracytidine-3' phosphate at low temperature.


The formation of riboflavin from 6,7-dimethyl-8-ribityllumazine in acid media.


Intramolecular participation in the hydrolytic deamination of 1-beta-D-arabinosylcytosine.


Tumor promoting compounds from Euphorbia triangularis: mono- and diesters of 12-desoxy-phorbol.


Photoreducation of 4- and 2-thiouracil and 4-thiouridine.


Subclinical Peyronie's disease.

Subclinical Peyronie's disease.


A comprative electron microscopic study of a leiomyosarcoma and bizarre leiomyoma (leiomyoblastoma) of the stomach.


A practical and efficacious method for obtaining significant postmortem blood cultures.


Aspiration biopsy of breast cancers by the pathologist.


The needle autopsy. A retrospective evaluation of 394 consecutive cases.


A ten-year study of mycotic infections in a Virginia general hospital.


Effect of antimicrobial agents on serum folate assay.


Performance of "kits" used for clinical chemical analysis of glucose.


Use of antiserums for blood group antigens S and K in studies of parentage.


Myelin figures in blood cells, lysosomes, and lipidoses.


Anaemia in parturient women, with special reference to malaria infection of the placenta.


Prevalence of tropical sprue in a hospital population in North India.


Mucosal leishmaniasis in the Sudan.

Mucosal leishmaniasis in the Sudan.


Trypanosome infection rates in the mouthparts of Zambian tsetse flies.


Bovine babesiasis: a study of factors concerned in transmission.


The experimental infection of reptiles with Trypanosoma brucei.


Methyridine in the treatment of experimental Capillaria hepatica infection in the rat.


An analysis of speciation and evolution in Wuchereria bancrofti by the study of nuclear constancy (eutely) in microfilariae.


Asparagine synthetase from gamma-irradiated potatoes.


DNA polymerase from rat liver chromosomal proteins. I. Partial purification and general characteristics.


The sulfhydryl nature of collagen proline hydroxylase.


The effects of temperature and ionic strength on the formation of the hydroxide complex of ferric horseradish peroxidase.


Isolation, purification, and characterization of Crithidia fasciculata cytochrome c555.


Origin of mitochondrial enzymes. 3. Distribution and synthesis of cytochrome c in rat liver tissue.


Reassessment of alkaline proteases and the presence of xanthine oxidase in mouse muscle.


The inhibition of active movements of Na+ and K+ in rat-liver slices by high concentrations of succinate and other carboxylate anions.


Problems of setting occupational exposure standards--background.


Malate dehydrogenase and aspartate aminotransferase of Phycomyces blakesleeanus.


Synthesis and properties of 2-amino-4-hydroxy-5,6-dimethyl-5,6,7,8-tetrahydropteridine and the 5,7-dimethyl isomer.


Current problems of setting occupational exposure standards.


Treatment of parkinsonism with levodopa.


Myopathic changes produced by local trauma.


Necrosis and regeneration of the tibialis anterior muscle in rabbit. II. Biochemical changes: lactate dehydrogenase, creatine kinase, and their isoenzymes in serum and muscle.


Phenolic acids in experimental uremia. I. Potential role of phenolic acids in the neurological manifestations of uremia.


Intracranial surgery in hemophiliacs. Report of a case and review of the literature.


Delayed radiation necrosis of the hypothalamus. Report of a case simulating recurrent craniopharyngioma.


The distribution of polyphenols in the tea plant (Camellia sinensis L.). 1. Methods for the separation and determination of the polyphenolic components of the tea plant by thin-layer chromatography and colorimetric reactions have been devised. 2. High concentrations of catechins, flavonols and depsides were found to be restricted to the young vegetative and floral shoots, whereas leucoanthocyanins or flavylogens were characteristic of the more bulky axial tissues of the plant. 3. In the young shoots cell growth was correlated with an increasing degree of flavonoid B-ring hydroxylation. 4. Maximal flavylogen concentrations occurred in the outer protective layers of stem and of seed coat. 5. Mature leaves were shown to contain derivatives of the flavones apigenin and luteolin. 6. Developing seedlings showed a steady increase in polyphenol complexity; flavylogens were concentrated at shoot and root apices and accumulated at the stem base. 7. It is postulated that the flavanols (leucoanthocyanins and catechins), because they can co-polymerize, are of use to the plant for protection of wood and bark against infection and decay.


The separation and distribution of simple and condensed leucoanthocyanins of the tea plant (Camellia sinensis L.). 1. Leucoanthocyanin monomers of high mobilities in aqueous solvents on thinlayer chromatograms, assumed to be structurally simple, were characteristic of mature bulky tissues, whereas members of lower mobility were confined to young vegetative and floral tissues. 2. Flavylogens were separated by gel filtration on Sephadex columns into monomeric, oligomeric and polymeric fractions. 3. The polymeric fraction from young brown stems was heterogeneous, one-half having a molecular weight of about 3400, one-third a molecular weight between 3600 and 17000, and the remainder a molecular weight of over 17000. 4. Leaves had low flavylogen concentrations; only monomers were present. Stem tissues were rich in polymers, which increased with the age of the young stem and decreased inwards through the wood. The maximal flavylogen concentrations were in the phloem and cambium from mature stems, where all three fractions were richly present. The periderm tissue and, to a lesser extent, the seed coat were characterized by a very high polymer/monomer ratio, exhibiting a much higher degree of polymerization than the wood. Root tissues contained high concentrations of monomers. 5. In general, there was an inverse correlation between the extent of polymerization and the complexity of the monomers present. 6. The results are in favour of the thesis that the function of the flavanols is, after polymerization to condensed tannins, to impregnate dead structural tissues and thereby to protect them from infection and decay.


Studies on the polyphenol metabolism of tissue cultures derived from the tea pant (Camellia sinensis L.). 1. The growth characteristics on various media of solid and liquid suspension cultures derived from the stem of the tea plant are described; chlorophyll and anthocyanin synthesis occurred in the light. 2. Only the simplest catechins and leucoanthocyanins were present in callus tissue, although oligomeric and polymeric leucoanthocyanin fractions were also represented. Light caused an increase in all monomeric components analysed, but inhibited polymerization of the leucoanthocyanins. 3. The polyphenol oxidase activity of cultures was comparable with that of the apical regions of the intact plant, and was inversely correlated with growth rate. 4. Growth was stimulated by hormonal variation, and inhibited by high concentrations of sucrose and by high light-intensity; polyphenol concentrations were generally inversely correlated with growth rate. 5. From the inability of callus tissue and of cultured root apices to synthesize complex catechins, it is inferred that complex catechin formation in intact plants is associated with the process of cell vacuolation.


The interaction of cytochrome c with monolayers of phosphatidylethanolamine. 1. The interaction between [(14)C]carboxymethylated cytochrome c and monolayers of egg phosphatidylethanolamine at the air/water interface has been investigated by measurements of surface radioactivity, pressure and potential. 2. On adding (14)C-labelled cytochrome c to the subphase under monolayers with a surface pressure below 24dynes/cm. there was an initial surface pressure increment as the protein penetrated, followed by an adsorption that could be detected only by a continued increase in the surface radioactivity. 3. Above film pressures of 24dynes/cm. only adsorption was observed, i.e. an increment in surface radioactivity with none in surface pressure. 4. The changes in surface parameters with penetration of cytochrome c added to the subphase were indirectly proportional to the initial pressure of the monolayer. With hydrogenated phosphatidylethanolamine the constant of proportionality was increased but penetration again ceased at 24dynes/cm. 5. On compressing a phosphatidylethanolamine film containing penetrated cytochrome c to 40dynes/cm. only a proportion of the protein was ejected on a subphase of 10mm-sodium chloride, whereas on a subphase of m-sodium chloride nearly all the protein was lost. 6. With both penetration and adsorption only a small proportion of the added cytochrome c interacted with the phospholipid films, and initially the amount bound was proportional to the added protein concentration. There was no evidence of a stoicheiometric relationship between the protein and phospholipid or the build-up of multilayers. The bonded protein was not released by removing cytochrome c from the subphase. 7. The addition of m-sodium chloride to the subphase delays the rate of protein penetration into low-pressure films, but the final surface-pressure increment is not appreciably decreased. In contrast, m-sodium chloride almost completely stops adsorption on to films at all pressures. 8. When sodium chloride is added to the subphase below cytochrome c adsorbed to monolayers at high pressures, so that the final concentration is 1m, only a proportion of the protein is desorbed and this decreases as the time of the interaction increases. This indicates that adsorption is initially electrostatic, followed by the formation of non-ionic bonds. 9. Alteration of the subphase pH under a high-pressure film leads to a steady increase in adsorption from pH3 to 8.5 followed by a rapid fall to zero adsorption at pH11. 10. The penetration into phospholipid monolayers at 10dynes/cm. shows a rate that is consistent with the relative electrostatic status of the two components of the interaction as the subphase pH is varied between 3 and 10.5. The final equilibrium penetration shows a pronounced peak in the increments of surface pressure at pH9.0 although a similar peak is not observed in the surface radioactivity. This indicates that more residues of the protein are penetrating into the film at about this pH. 11. Determinations were made of the electrophoretic mobilities of phosphatidylethanolamine particles both alone and after interaction with cytochrome c. 12. The electrophoretic mobilities of cytochrome c adsorbed on lipid particles showed an isoelectric point below that of cytochrome c. This and the observations on the monolayers suggest that, with cytochrome c, protein-protein interactions are weak compared with other proteins.