Hyaluronic acid in synovial fluid. 3. Effect of maturation and aging on the chemical properties of bovine synovial fluid of different joints.


Diminution of bone blood flow and capillary network in rats during aging.


The effect of age on renal functions of female rats.


The effect of age on hair growth in the CBA mouse. Observations on repeated plucking.


Compound criteria in gerontological research.


Comparing factor trait and state scores across ages and cultures.


Wives' attitudes toward nursing homes.

Wives' attitudes toward nursing homes.


Induction, colonial morphology, and growth characteristics of the L-form of Streptococcus liquefaciens.


Surveillance of nosocomial infections in community hospitals. I. Surveillance methods, effectiveness, and initial results.


Response of canine Thiry-Vella jejunal loops to cholera exotoxin and its modification by ethacrynic acid.


Two variants of Sindbis virus which differ in interferon induction and serum clearance. I. The phenomenon.


Two variants of Sindbis virus which differ in interferon induction and serum clearance. II. Virological characterizations.


Susceptibility to infection with Pasteurella tularensis and the immune response of mice exposed to continous low dose rate gamma radiation.


Interferon response during Coxsackie B-3 infection in mice. I. The effect of cortisone.


Lymphogranuloma venereum. I. Comparison of the Frei test, complement fixation test, and isolation of the agent.


From the national communicable disease center. Shigellosis in the United States. 1964-1968.


Recent outbreaks of trichinosis in the United States.


Some interferon research in the National Institute of Allergy and Infectious Diseases.


Irreversible enzyme inhibitors. CLVII. Effect of bridge modification on the selective irreversible inhibition of dihydrofolic reductase from L1210 mouse leukemia and liver by 2,4-diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosultonyl-benzamidomethyl) phenozymethyl]pyrimidine. I.


Carboxymethylation of sulphydryl groups in proteolipids.


Activators and inhibitors of brain glutaminase.


Synthesis of RNA in neurons of the hypoglossal nerve nucleus, after section of the axon, in mice.


Effects of DI-n-propylacetate, and anticonvulsive compound, on GABA metabolism.


Comparative studies of highly basic proteins of ox brain and rat brain. Microheterogeneity of basic encephalitogenic (myelin) protein.


Some effects of monoamine oxidase inhibitors on the metabolism of gamma-aminobutyric acid in rat brain.


Estimation of glycolipids in four selected lobes of human brain in neurological diseases.


Lack of abnormality in brain aromatic amines in rats and mice susceptible to audiogenic seizure.


Effect of ions on stimulus-induced release of amino acids from mammalian brain slices.


Glucose and amino acid metabolism in some invertebrate nervous systems.


Glucsoe and amino acidmetabolism in octopus optic and vertical lobes in vitro.


Brain serotonin changes in phenylalanine-fed rats: synthesis storage and degradation.


Studies on the labelling patterns of RNA from cerebral cortex nuclei.


Morphogenesis and migration of Ascaris suum larvae developing to fourth stage in swine.


Distribution of meningeal worm (Pneumostrongylus tenuis) in deer in the southeastern United States.


Studies on delayed (cellular) hypersensitivty in mice infected with Trichinella spiralis. IV. Artificial sensitization of donors.


Trichinella spiralis in mammals at Mountain Lake, Virginia.


Antagonistic interaction between strigeid and schistosome sporocysts within a snail host.


Purification of Eimeria tenella sporozoites with glass bead columns.


Amylopectin, the storage polysaccharide of the Coccidia Eimeria brunetti and E. tenella.


Five new species of the unique genus Polylopadium (Acarina: Trombiculidae).


"Schistosomulum," "schistosomula," or "schistosomule"?


Transformation of mictic index through a diploid individual.


Optical determination of the thickness of thin lipid films.


The "independence principle" of biological membranes: its misuse.


A stochastic approach to the development of Coleocheate.


Theoretical aspects of termination of immune tolerance by cross-reacting antigens.


Contrast agent design. Some aspects on the synthesis of water soluble contrast agents of low osmolality.


Circadian rhythms in fluctuating light cycles: toward a new model of entrainment.


A table of mean effective temperatures for the metabolism of biological systems subjected to sinusoidal cycls in temperature.


The ultrastructure of the epidermis in lichen ruber planus as revealed by electron microscopy. I. Dermo epidermal junction, stratum basale, and lower stratum spinosum.


In vivo and in vitro demonstration of nuclear bodies in vaccinia infected cells.


Sarcolemmal evaginations with knob-like or stalked projections in Purkinje fibers of the sheep's heart.


Ca2+ and K+ ion effects on ultrastructure of isolated flounder kidney tubules.


An electron microscopic study of normal mouse lung and the early diffuse changes following uracil mustard administration.


Electron microscopic studies of mast cells of human fetal skins.


The development and fine structure of the allantoic placental barrier in the bat Tadarida brasiliensis cynocephala.


Formation of coated and "synaptic" vesicles within neurosecretory axon terminals of the crustacean sinus gland.


Four types of main cells in the carotid body of the cat.


Thylakoid anomalies in relation to grana structure in pigment-deficiency mutants of Zea mays.


A comparative study of stromal swelling in sea lamprey spectacle and brook trout cornea.


Ultrastructural studies on inclusion formation and virus occlusion in nuclear polyhedrosis and granulosis virus-infected cells of Trichoplusia ni (Hübner).


The unusual nature of root formation in molar teeth of the laboratory rat.


Clinical uses of closed-circuit television.


Specific inhibition of immunocompetence.


Multiple intracranial aneurysms associated with metastatic malignancy of brain.


XY gonadal dysgenesis and gonadoblastoma. Report of a case.


Face-down position for repair of vesicovaginal fistula.


Verrucous carcinoma of the vulva.

Verrucous carcinoma of the vulva.


Effect of human chorionic gonadotropin on urinary 17-ketosteroids and vaginal cytology in ovariectomized patients.


Ultrasonic scanning in obstetrics and gynecology.


Urinary estriol excretion in high-risk pregnancy.


Plasma lipid and lipoprotein alterations during oral contraceptive administration.


Oral progestins and regression of carcinoma in situ and cervical dysplasia. A cytologic evaluation.


Traumatic rupture of the placenta. A rare cause of fetal death.


Massive edema of the ovary simulating fibroma.


Laparoscopy in gynecology.

Laparoscopy in gynecology.


X-ray diagnosis of advanced extrauterine pregnancy.


An adolescent guidance program. Study in education for marital health.


Clinical trial of a metal clip for cervical biopsy.


Obstetric anesthesia coverage: problems and solutions.


Elective hysterectomy.

Elective hysterectomy.


Light-induced sporulation and sporogenic substances in fungi.


Cell wall differentiation in the phycomycetes.


Vertebral destruction at unfused segments in late ankylosing spondylitis.


Point spread-function, line spread-function, and modulation transfer function. Tools for the study of imaging systems.


Bronchial rearrangements in pulmonary collapse as seen on the lateral radiograph.


Effect of doxepin on the norepinephrine pump. A preliminary report.


Differential response of rapidly and slowly proliferating human cells to X irradiation.


Effects of thoracic irradiation on pulmonary arterial perfusion in man.


Metronidazole and placebo in the treatment of chronic alcoholism. A comparative study.


The influence of prior knowledge on visual search strategies during the viewing of chest radiographs.


Current concepts of depression.

Current concepts of depression.


Tomographic evaluation of trauma to the temporal bone.


On measuring psychotherapeutic action.

On measuring psychotherapeutic action.


Angiography of calvarial hemangioma. Report of a case.


Isochronous cyclotron installation for radionuclide production.


Evaluation of a mercury-203 exposure.

Evaluation of a mercury-203 exposure.


Biphasic drugs in the treatment of depression with anxiety.


Primary megaloureter.

Primary megaloureter.


Asplenia associated with infradiaphragmatic total anomalous pulmonary venous return and esophageal varices.


The diagnosis of traumatic laceration of the spleen by selective arteriography, direct serial magnification angiography, and intra-arterial epinephrine.


Errors in angiographic diagnosis of renal masses.


Value of delayed filming in the anterior tibial compartment syndrome secondary to trauma.


Spasticity of the lower extremities following abdominal aortography.


Addition of polymer to radiopaque contrast material to decrease catheter flow resistance.


Unique vascular colon stenoses.

Unique vascular colon stenoses.


Peroral irradiation of carcinoma of the oral tongue.


Three-dimensional dose distribution in cobalt-60 teletherapy of the head and neck.


Radiation therapy in retinoblastoma. An analysis of 230 cases.


The abscopal effect in malignant lymphoma and its relationship to lymphocyte circulation.


Evaluation of primary radiation therapy in stage I, group 2, endometrial carcinoma.


RPC of the month from AFIP.

RPC of the month from AFIP.


Roentgen-guided infarctions of kidneys and lungs. A potential therapeutic technic.


Radiochemical purity of short-lived technetium 99m from commercial suppliers.


Fifty-fifth Scientific Assembly and Annual Meeting. The Radiological Society of North America, Inc.


Medical school radiology teaching and examination methods.


Intercalative angiocardiography: a method for recording cardiovascular dynamics on a single film.


The secondary pulmonary lobule: a practical concept for interpretation of chest radiographs. I. Roentgen anatomy of the normal secondary pulmonary lobule.


The secondary pulmonary lobule: a practical concept for interpretation of chest radiographs. II. Application of the anatomic concept to an understanding of roentgen pattern in disease states.


Angiocardiographic findings in tricuspid atresia: correlation with hemodynamic and morphologic features.


Correlation of radiologic, histologic, and clinical findings in agnogenic myeloid metaplasia.


Clinodactyly, camptodactyly, Kirner's deformity, and other crooked fingers.


Xeroradiography of the bones, joints, and soft tissues.


Radiographic development of skeletal lesions in man many years after acquistion of radium burden.


Indium-113m radiopharmaceuticals for multipurpose imaging.


113m in (aluminum) hydroxide particles for lung scanning.


Radionuclear (75Se) identification of tumor in children with neuroblastoma.


Changes in the transverse cardiac diameter following mediastinal irradiation for Hodgkin's disease.


Radiation-induced delayed union of fractures.


Radiation-induced major vascular occlusion in a patient cured of widespread metastases of nasopharyngeal origin.


Gastric changes during an attack of acute intermittent porphyria.


Communicating enterogenous cyst of duodenum receiving the termination of the common bile duct demonstrated by intravenous cholangiography.


RPC of the month from the AFIP.

RPC of the month from the AFIP.


Special procedure tables: an angiographic aid.


A simplified dual-probe thyroid-uptake system.


A 70-mm recording system for the Anger camera.


A simple aid for peripheral venography.

A simple aid for peripheral venography.


Treatment of lymphedema of the limbs by lymphatic-venous fistula.


Long-term management of cardiac pacemakers with a systematic approach to malfunction: report of 37 cases.


The importance of the pulmonary veins in systemic air embolism following open-heart surgery.


Beta-adrenergic receptors and gastric acid secretion.


An abnormal portal vein.

An abnormal portal vein.


Urethral extension of vesical neoplasm.

Urethral extension of vesical neoplasm.


Appendicoenterosigmoid fistula.

Appendicoenterosigmoid fistula.


Further evidence of the role of the reticuloendothelial system in the maintenance of vascular integrity.


Hemodynamics of the experimental dumping syndrome.


Effect of chronic anemia on the tensile strength of healing wounds.


Acute pancreatitis: an experimental model.


The anatomic pathways of the vagal fibers to the antral mucosa.


Effects of sinus nerve stimulation on arterial resistance and flow patterns of specific vascular beds.


Acute cardiovascular effects of vena cava interruption: ligation versus clip compartmentation with cardiac output and flow measurements.


The effect of heparin in experimental fat embolism.


Long-term plastic tubing implantation into the external jugular vein for injection or infusion in the dog.


Improved experimental red cell mass measurement.


Safe hepatic artery occlusion in dogs.

Safe hepatic artery occlusion in dogs.


Augmentation of membrane gas transfer by induced secondary flows.


Effect of low molecular weight dextran on circulatory dynamics and oxygen consumption in experimental hemorrhagic shock.


Gastric teratoma in a newborn infant: total gastrectomy with survival.


Ventral silon pouch: method of repairing congenital diaphragmatic hernias in neonates without increasing intra-abdominal pressure.


An improved tunneling device for vascular reconstruction.


Incision for cardiac pacemaker pouch.

Incision for cardiac pacemaker pouch.


Effect of protein dietary supplementation on the physical performance of Marine Corps officer candidates. MF12.524.009-8006B.1.


Visual pigments of the vitamin A-deficient rat following vitamin A2 administration.


An elemental theory of induction.

An elemental theory of induction.


Temporal and spatial interactions involved in the band movement phenomenon.


The colors of Benham's top under metameric illuminations.


Comparison of saccadic eye movements during fixation and reading.


Clinical evaluation of transfused blood after long-term storage in ACD with adenine.


Tracking eye movements with and without saccadic correction.


Alteration of deformability of the erythrocyte membrane in stored blood.


A note on the refraction and image formation of the rat's eye.


Cryoprecipitates in treatment of congenital fibrinogen deficiency. Case report.


[A simple measuring arrangement for registration of electrochemical oxygen determination in liquids].


Pooled platelet concentrates prepared in a new blood bank centrifuge.


Amino groups at the surfaces of phospholipid vesicles.


Physical studies of myelin. II. Proton magnetic resonance and infrared spectroscopy.


Physical studies of phospholipids. XII. Nuclear magnetic resonance studies of molecular motion in some pure lecithin-water systems.


The interaction energies of cholesterol and lecithin in spread mixed monolayers at the air-water interface.


Mixed monolayers of phospholipids and cholesterol.


Nuclear magnetic resonance spectroscopic studies of procaine hydrochloride and tetracaine hydrochloride at lipid-water interfaces.


The effect of membrane-strain rate and of temperature on erythrocyte fragility and critical hemolytic volume.


Membrane expansion of intact erythrocytes by anesthetics.


Membrane expansion of the erythrocyte by both the neutral and ionized forms of chlorpromazine.


Temperature dependen of erythrocyte membrane expansion by alcohol anesthetics. Possible support for the partition theory of anesthesia.


The membrane concentration of a local anesthetic (chlorpromazine).


Vesicular transport across endothelial cells.


Ionic fluxes in cells of Chara corallina.


Slow cis-stimulation of sodium transport across isolated urinary bladders of the fresh-water turtle, Pseudemys scripta.


The accumulation of calcium in laying fowl intestine in vitro.


Transport of nonmetabolizable amino acids in rat liver slices.


Amino acid transport in rat-liver slices during development.


A cross-inhibition of basic amino acid transport by neutral amino acids.


Stereochemical specificity of neutral amino acid transfer systems in rat small intestine.


Preferential binding of amino acids to isolated mucosal brush borders from hamster jejunum.


On the number of sodium pumping sites in cell membranes.


The effect of growth hormone and cortisone on thymidine kinase activity in rat adipose tissue.


The synthesis and processing of ribosomal RNA precursor molecules in yeast.


The relationship between histone and DNA synthesis in HeLa cells.


Function of chloroplast DNA. II. Studies on DNA-dependent RNA polymerase activity of tobacco chloroplasts.


Reduction of X-ray-induced DNA and thymine hydroperoxides by rat liver glutathione peroxidase.


Poly U stimulation of single ribosomes and of ribosomes engaged in polysomes of sea urchin eggs and embryos.


Unique secondary structure of newly replicated HeLa DNA.


Chromatin binding of benzo(a)pyrene and 20-methylcholanthrene.


DNA cryolysis.

DNA cryolysis.


Kinetic aspects of DNA cryolysis.

Kinetic aspects of DNA cryolysis.


Glycoprotein synthesis by membraneound ribosomes and smooth membranes in kidney.


Incorporation of L-[14C]leucine into the nucleoli of mouse ascites tumor cells.


Resistance of liver polysomes to ATP deficiency in the male rat.


Studies on the conidia of Aspergillus oryzae. IX. Protein synthesizing activity of dormant conidia.


Studies on ornithine decarboxylase activity in normal and regenerating livers.


Fluorescence of nucleic acids with ethidium bromide: an indication of the configurative state of nucleic acids.


Absolute requirement for transfer RNA in the activation of arginine by arginyl transfer RNA synthetase of yeast.


5-Hydroxymethylcytosine-containing Klebsiella bacteriophage.


On a messenger ribonucleoprotein complex from rabbit reticulocytes.


The mode of action of oestradiol. I. The transport of RNA precursors into the uterus.


The mode of action of oestradiol. II. The synthesis of RNA.


Rapid serial simultaneous biplane stereoscopic angiography; an aid in the surgical management of the cerebral arteriovenous malformations.


The metabolism of L- and DL-malic acids by rats.


Acute toxicity of sterigmatocystin to rats.


Standard values in the beagle dog: haematology and clinical chemistry.


Uterine and tubal transplantation.

Uterine and tubal transplantation.


Evaluation of a new combination oral contraceptive: lynestrenol-mestranol (Lyndiol).


A comparison of two methods for the measurement of erythrocyte cholinesterase inhibition after carbamate administration to rats.


Early diagnosis of diabetes in Munich, 1967-1968.


Azoospermia due to complete aplasia of the germinal epithelium.


Experimental studies on reversible vas occlusion by intravasal thread.


The intrafamilial transmission of rheumatoid arthritis: an unusual study.


Preparation of sulfanilamide from aniline. An organic chemistry experiment.


Effect of coitus on barbiturate-blocked ovulation in immature rats.


Duration of the cycle of the seminiferous epithelium in the mouse and hamster determined by means of 3H-thymidine and radioautography.


Emotional factors in the success of contraception.


The intrafamilial transmission of rheumatoid arthritis. I. Design of the study.


Influence of smoking and adrenaline (epinephrine) on the uterotubal insufflation test (Rubin test).


Suppression of ovulation with human chorionic gonadotropin.


The intrafamilial transmission of rheumatoid arthritis. II. An interview measure of rheumatoid arthritis.


The intrafamilial transmission of rheumatoid arthritis. 3. The lack of support for a genetic hypothesis.


The intrafamilial transmission of rheumatoid arthritis. IV. Recalled parent-child relations by rheumatoid arthritics and controls.


The intrafamilial transmission of rheumatoid arthritis. V. Differences between rheumatoid arthritics and controls on selected personality variables.


The intrafamilial transmission of rheumatoid arthritis. VI. Association of rheumatoid arthritis with several types of status inconsistency.


The intrafamilial transmission of rheumatoid arthritis. VII. Why do wives with rheumatoid arthritis have husbands with peptic ulcer?


Right ventricle and tricuspid valve in mitral valve disease.


The effect of cold on hind-limb growth and lateral motor column development in Rana pipiens.


The intrafamilial transmission of rheumatoid arthritis. 8. Summary of findings.


Blood lipids and lipoproteins, glucose tolerance and plasma insulin response in Chinese men with and without coronary heart disease in Hawaii.


The mitotic pattern of the embryonic epidermis of chick during scale morphogenesis.


Myocardial cell death in the embryonic chick ventricle.


RNA synthesis in te early embryogenesis of a fish (Misgurnus fossilis).


Effects of beta-mercaptoethanol on the fine structure of the neural plate cells of the chick embryo.


Myogenesis in chick embryo somites in vitro.


Development of luxoid (lu) skeletal defects in vitro.


Haemoglobins of the foetal and adult rat: sites of synthesis and the effects of erythropoietin.


Formation de novo and development of neuromuscular junctions in vitro.


Reversible nephropathies.

Reversible nephropathies.


Sex difference and gonadal hormone influence on Syrian hamster kidney esterase isozymes.


Quantitative histochemistry of rachitic rat cartilage enzyme activity during healing induced by vitamin D and starvation.


Structure of gamma-chymotrypsin at 5.5 A resolution.


The role of radioactive isotopes in the diagnosis of gastro-intestinal disease.


Anesthetic sprays and wipes.

Anesthetic sprays and wipes.


Gatorade and other oral electrolyte solutions.


Catecholamine chemical species at the adrenergic receptors.


Rifampicin and poxvirus replication.

Rifampicin and poxvirus replication.


"Lymphokines": non-antibody mediators of cellular immunity generated by lymphocyte activation.


Lymphocyte mitogenic factor in man.

Lymphocyte mitogenic factor in man.


DDT induces a decrease in eggshell calcium.


Marked DDE impairment of mallard reproduction in controlled studies.


Conformation of human serum high density lipoprotein and its peptide components.


Evidence against orientation of water in rat phrenic nerve.


Modification by crude histones of gene activity for lactate dehydrogenase.


Third sublocus in the HL-A human transplantation system.


Crossing-over within the HL-A system.

Crossing-over within the HL-A system.


Unresponsiveness of mixed leucocyte cultures from thymectomized adult dogs.


Bronchodilator activity of an aerosol of prostaglandin E1 in experimental animals.


Effects of noradrenaline on the membrane potential and ionic permeability of parenchymal cells in the liver of the guinea-pig.


Relation of regenerating nerve terminals to original endplates.


Antifertility effects and metabolism of alpha and epi-chlorhydrins in the rat.


Mitochondrial increase after long-term feeding of morfamquat.


Metabolic activity of the Ehrlich ascites carcinoma cells and the significance of ascites serum addition.


In vitro studies on the cytotoxic properties of 9-amino-nitroacridine derivatives.


Neurologic disorder of thiamine deficiency.


Sex chromatin and hormonal treatment in breast cancer with bone metastases.


Hyperthyroidism, niacin, and isonicotinic acid hydrazide (INAH): effects on sarcoma 180.


Investigations of the change of bioelectrical reactions of the brain to barbiturates after head trauma.


Bradykinin and vasoconstriction in the perfused rat liver.


Tyrosine and thyronine analogs and inhibitors of the dye-sensitized photoinactivatioof lysozyme.


Biliary excretion of thyroid hormones in heat-exposed rats.


Hepatic vein pressure determination and phlebography in the evaluation of portal hypertension.


Intravenous glucose tolerance in late pregnancy.


Arcus senilis corneae--its relationship to serum lipids in the South African Bantu.


Multiple sclerosis in South Africa.

Multiple sclerosis in South Africa.


Oesophageal cancer in Natal Bantu: a review of 516 cases.


Hereditary renal disease,retinitis pigmentosa and other anomalies.


Medical certificates.

Medical certificates.


Health service administration in developing countries.


Consumptive coagulopathy caused by a boomslang bite.


Depression in African patients.

Depression in African patients.


Margarine.

Margarine.


Injuries of the chest.

Injuries of the chest.


Hypertrophy of the pyloric muscle in gastric ulceration.


Heterotopic prostatic tissue:A REPORT OF AN UNUSUAL CAUSE OF HAEMATURIA IN A Bantu youth.


Partial anomalous pulmonary venous drainage from the upper lobe of the left lung.


Defintion of mental health and mental ill-health.


Carcinoma of the oesophagus.

Carcinoma of the oesophagus.


Competitive effects of estradiol-17-alpha on the estradiol-17-beta induced physical changes in uterine DNA.


Characterization of the 21-yl sulfates of 11-beta, 17-alpha,21-trihydroxypregn-4-ene-3,20-dione; 17-alpha,21-dihydroxypregn-4-ene-3, 11,20-trione; 11-beta,21-dihydroxyregn-4-ene-3,20-dione; 21-hydroxypregn-4-ene-3, 11,20-trione and 21-hydroxypregn-4-ene,3,20-dione in human cord plasma.


Formic acid as a prophylactic for candidasis in partridges.


Farmer's lung.

Farmer's lung.


Forward extension of the breeding season in sheep.


Comparison of the intraretinal b-wave and d.c. component in the area centralis of cat retina.


High-intensity effects on slow potentials and ganglion cell activity in the area centralis of cat retina.


Structure of the cat's retina after occlusion of the retinal circulation.


Spectral sensitivity of retinal screening pigment migration in the frog.


Contrast response of human visual mechanismsensitive to orientation and direction of motion.


The localization of radioactive amino acid taken up into the outer segments of frog (Rana pipiens) rods.


Visual beats: differential brightness of the stimuli and estimation of brightness.


Yellow corneas in fishes.

Yellow corneas in fishes.


The filling-in process in patients with retinal scotomata.


Inhibitory effect of DEAE-dextran on tumour growth. (1). Action of dextran sulphate after "in vitro" incubation.


Adenomas of the small intestine. A report of four cases with special reference to their relation to carcinomas.


The permeability of mesothelium to horseradish peroxidase. A light and electron microscopic study, with special reference to the morphology of pericardial mast cells.


Marked cross-agglutination between Brucellae and a subtype of Yersinia enterocolitica.


Alveolar rhabdomyosarcoma.

Alveolar rhabdomyosarcoma.


The occurrence of virus and interferon in spleen, serum and brain in steroi-treated mice under experimental infection with West Nile virus.


Position and orientation of the heart valves.


Flavobacterium meningosepticum isolated from outside hospital surroundings and during routine examination of patient specimens.


Morphological and biochemical observations on the catecholamine-storing vesicles of rat adrenomedullary cells during insulin-induced hypoglycemia.


Electron microscopical study of relaxation and constriction in frog arterioles.


Uptake and storage of Thorotrast by the rodent yolk sac placenta: an electron microscopic study.


Development of the lateral musculature in the teleost, Brachydanio rerio: a fine structural study.


Chronic mucocutaneous candidiasis as a surface expression of deep-seated abnormalities. Report of a syndrome of superficial candidiasis, absence of delayed hypersensitivity and aminoaciduria.


Hypertension associated with tumors adjacent to renal arteries.


Cerebral venous and arterial blood gases during Cheyne-Stokes respiration.


Schistosomiasis Japonica. Treatment by extracorporeal hemofiltration.


Endemic fluorosis in Punjab (India).

Endemic fluorosis in Punjab (India).


Afibrinogenemia in man following the bite of a rattlesnake (Crotalus adamanteus).


Cushing's syndrome with hypertensive crisis and mixed adrenal cortical adenoma-pheochromocytoma (corticomedullary adenoma).


Pseudoketosis and hyperacetaldehydemia in paraldehyde acidosis.


A study of the cardiac innervation in domestic animals: cattle.


The Purkinje cell cilium.

The Purkinje cell cilium.


Origin of amphibian premelanosomes and their relation to microtubules.


Development of the amphibian pineal organ; cell proliferation and migration.


The fine structure of endothelial cells of toad arteries.


The fine structure of the extracellular matrix during epithelio-mesenchymal interactions in the rabbit embryonic incisor.


Tracers and endogenous debris in delineating cochlear barriers and pathways, an experimental study.


Dentaural hearing testing, calibrating bone conduction through the teeth.


Myringoplasty.

Myringoplasty.


Cholinergic control of cochlear blood flow.


Experimental human exposure to methyl chloroform vapor.


Specificity of the iodine-azide test for carbon disulfide exposure.


Metabolism of methyl mercury (203Hg) compounds in man.


Response to a low concentration of mercury vapor. Relation to human porphyrin metabolism.


Inhibition of aflatoxin carcinogenesis by diethylstilbestrol in male rats.


The acute toxicity of reactor polyphenyls on the lung.


Investigation of a population exposed to organomercurial seed dressings.


Carbon monoxide and survival from myocardial infarction.


Suicide among chemists.

Suicide among chemists.


Impact on personal freedom.

Impact on personal freedom.


Mining work in high altitude.

Mining work in high altitude.


The population crisis. The major problem in environmental control.


Diminishing lebensraum in the sky.

Diminishing lebensraum in the sky.


Capacitance respirometry.

Capacitance respirometry.


Preventing manual handling and lifting injuries in industry.


Ergonomics in England.

Ergonomics in England.


Perspectives on industrial visual standards.


Electrophysiology of the human visual system.


Pathology and ultrastructure of the human parathyroid glands in chronic renal failure.


Radioimmunoassay of parathyroid hormone.


Circulating parathyroid hormone concentration in chronic renal insufficiency.


Urinary parathyroid hormone-like activity in patients with uremia.


In vitro studies of normal and abnormal parathyroid tissue.


Environmental and genetic factors in idiopathic hemochromatosis.


Paradoxical pulse; a manifestation of the thoracic outlet syndromes.


Spontaneous conversion of established atrial fibrillation. Clinical significance of a change to atrial flutter or to paroxysmal atrial tachycardia with AV block.


Recurrent parathyroid adenoma.

Recurrent parathyroid adenoma.


Changes in salivary electrolytes following treatment of primary aldosteronism.


New curricula and training for patient care.


Energy transfer in poly-L-tyrosine as a function of the degree of ionization of the phenolic hydroxyls. IV. Calculations of theoretical transfer rates.


Energy transfer in poly-L-tyrosine. V. Fluorescence polarization studies.


Mercurial-induced circular dichroism changes of phycoerythrin and phycocyanin.


Purification from porcine pancreas of two molecular species with lipase activity.


The absence of alpha-keto acids in polymeric collagen.


Immunological properties of a collagen-like synthetic polypeptide.


Unreactive epsilon-amino groups in collagens.


The use of agarose for the preparation of pure 19-S thyroglobulin.


The heme binding group of a microsomal hemoprotein 559.


The molecular weight of adenosine deaminase in a number of species.


Adult fowl haemoglobin and its acetylation.


Isolation and partial characterization of a basic protein from bovine sperm heads.


Haematocrit variations and electromagnetic flowmeter sensitivity.


The MBI electromagnetic blood flowmeter.


Investigative laser surgery: safety aspects.


Contraceptives and cervical carcinoma.

Contraceptives and cervical carcinoma.


Complications of vacuum extraction.

Complications of vacuum extraction.


Hemochromatosis and venesection.

Hemochromatosis and venesection.


Peptic ulcer: surgical treatment.

Peptic ulcer: surgical treatment.


Sugar and ischaemic heart disease.

Sugar and ischaemic heart disease.


Azathioprine for the nephrotic syndrome.


Testing for phenylketonuria.

Testing for phenylketonuria.


Containers for specimens.

Containers for specimens.


Design of ambulances.

Design of ambulances.


Psychiatric aspects of multiple sclerosis.


Front-seat hazards.

Front-seat hazards.


Diagnostic tests for advenced cancer.

Diagnostic tests for advenced cancer.


Social class gradients and serum uric acid in males and females. The relation between serum uric acid and social class is examined by sex among 910 persons in Wensleydale, Yorkshire, 321 persons in Watford, Hertfordshire, and 1,213 persons in New Haven, Connecticut, all of whom were drawn from the general population. Among the men of Wensleydale there is a tendency of marginal significance at the 5% level for serum uric acid to increase with decreasing social class; in the New Haven women this same trend is significant at the 2.5% level; no trend was found among any of the other four sex-specific groups. Age did not account for the patterns observed. The difference between these findings and those of several studies from the United States is consistent with the view that both serum uric acid levels and gout are under multifactorial control.


Observations on neutropenia associated with haemodialysis. In the first 30 minutes of haemodialysis, in patients with chronic renal failure, there is a dramatic fall in total neutrophil count in the peripheral blood. An hour after the start of dialysis this has returned to normal.We have carried out a series of experiments in an attempt to elucidate the cause of this neutropenia. Both the patient and the membranes of the dialyser appeared to be a necessary combination to produce these changes, which could not be induced by the infusion of blood or saline that had previously been in contact with the dialyser. The composition of the dialysing fluid was not related to the fall of white count, and this fall was repeated when the patient was connected to a second dialyser after recovering from the neutropenia caused by the first. It was only when reusing a kidney, by rinsing it out and resterilizing it, that the neutropenia could be modified, but this was not a constant finding.


Venous effects of oral contraceptives.

Venous effects of oral contraceptives. In a five-year analysis of an oral contraceptive trial by the Council for the Investigation of Fertility Control venous effects were the third most troublesome group of side-effects with both combined and sequential therapy. Vein complaints, leg cramps, and thrombophlebitis were significantly more frequent with the combined preparations that contained a relatively low dose of progestogen and a high dose of oestrogen than with the other groups tested. No cases of thrombophlebitis occurred in women taking the strongly oestrogenic sequential groups.Histological examination of uterine curettings showed that most progestogenic combined preparations were associated with a high incidence of dilated endometrial sinusoids, while the oestrogenic sequential regimens and low-dose progestogen-only regimens had a low incidence. The incidence of stromal condensation round the sinusoids correlated with the incidence of leg cramps, and these effects appeared to be specific for each preparation tested.


Uric acid and plasma lipids in cerebrovascular disease. I. Prevalence of hyperuricaemia. Serum uric acid levels measured by the phosphotungstic sodium cyanide method have been estimated in 60 patients suffering from a cerebrovascular incident. Patients with diseases known to predispose to hyperuricaemia were excluded. Twenty-five per cent. of patients with acute strokes had hyperuricaemia, and this did not appear to be a transitory phenomenon. These findings suggest that hyperuricaemia may be one of the factors in the pathogenesis of atheroma.


Iatrogenic epilepsy due to antidepressant drugs. AN ANALYSIS OF THE CASE HISTORIES OF NINE PATIENTS WHO DEVELOPED EPILEPTIC FITS SHORTLY AFTER STARTING TRICYCLIC ANTIDEPRESSANT DRUGS SHOWED THAT ALL OF THEM HAD ONE OR MORE OF THE FOLLOWING FACTORS: previous or family history of epilepsy, pre-existing brain damage, cerebral arteriosclerosis, alcoholism, withdrawal of barbiturates, and history of previous electric convulsive therapy. Before prescribing antidepressant drugs these factors should be sought for in the history, and if any are present prophylactic anticonvulsant medication is indicated. From a limited experience we do not think that chlordiazepoxide is adequate to counteract the convulsant effect of antidepressant drugs.


Hypertension due to hypernephroma.

Hypertension due to hypernephroma.


Subarachnoid haemorrhage.

Subarachnoid haemorrhage.


Systemic corticosteroid therapy.

Systemic corticosteroid therapy.


Peptic ulcer. Advances in diagnosis.

Peptic ulcer. Advances in diagnosis.


Maternal rubella after the first trimester.


Computers on the march.

Computers on the march.


Overseas aid.

Overseas aid.


Neutron radiography.

Neutron radiography.


Control of anticoagulants.

Control of anticoagulants.


Changing incidence of trachoma in the West Midlands. An increasing incidence of trachoma in an urban Midland population has been shown to be mainly due to immigration of infected carriers from the Punjab. In areas where trachoma is common special clinics should be established for the treatment and follow-up of patients and contacts. Public health measures should be introduced to prevent the spread of the infection. Laboratory methods should be more widely used in the diagnosis and control of trachoma.


Some effects of motor-car driving on the normal and abnormal heart. Electrocardiograms were recorded in experienced motor-car drivers accustomed to busy city traffic while driving their own cars along familiar routes. The majority with normal hearts or a history of coronary heart disease increased their heart rates; brief periods when the rate exceeded 140/min. were recorded in both groups. ST changes not caused by tachycardia developed in 3 out of 32 normal drivers. Of 24 drivers with coronary heart disease 13 increased their ST and T abnormalities, the changes being gross in six. A further five developed multiple ventricular ectopic beats. Two coronary drivers experienced anginal pain and two left ventricular failure. Healthy motor-racing drivers increased their heart rates to 180/min. in the few minutes before the start of a race and to above 200/min. while racing.Little or no change in the plasma catecholamine levels was noted in three coronary subjects immediately after a city drive compared with resting levels. All the racing drivers showed a considerable increase in noradrenaline, and in one instance adrenaline, immediately after racing.Persons in whom angina is easily provoked when driving or who are in borderline left ventricular failure should be advised not to drive.


Recognition and management of dissecting aneurysms of the aorta. The current approach to treatment at St. Mary's Hospital of dissecting aortic aneurysms uses a period of induced hypotension before aortography and consideration for surgical correction. There are 13 survivors of a series of 24 patients treated in this way.


A 60 percent oxygen supply for medical use. A supply of 60% oxygen with 40% nitrogen should be acceptable for most clinical purposes, since usually only low dosages of oxygen are required. The gas may be provided by means of an oxygen concentrator (Rimer-Birlec), which is a compact, transportable, electrically operated apparatus capable of providing 28 l./min. (1 cu. ft./min.) of 60% oxygen from a source of compressed air. The biological effect of the gas from the device is the same as that of 60% oxygen from a conventional source. Measurements of inspired oxygen concentration show that the 60% oxygen may be used with present-day oxygen masks to provide inspired oxygen concentrations in the range 25 to 40%; for higher inspired concentrations alternative equipment is likely to be required. The concentrator appears to be a practical source of oxygen for expeditions and out-of-the-way places. It may provide an economical supply for a ward block, and with further development should be a convenient source of 30% oxygen for domiciliary use.


"Antimongolism" syndrome.

"Antimongolism" syndrome.


Road accidents and the family doctor. Medical organization.


Chronic paediatric neurological disorders. I.


Research in the field of psychiatry.

Research in the field of psychiatry.


Potassium supplements.

Potassium supplements.


Depressive changes after fluphenazine treatment.


Autoimmunization in human malignant melanoma.


Rat and human chromosome studies after promazine medication.


Extra-articular manifestations of rheumatoid arthritis.


Asthma deaths in Eire.

Asthma deaths in Eire.


Tumoral calcinosis.

Tumoral calcinosis.


Practical spectrophotometric standards.

Practical spectrophotometric standards.


Measurement of cholesterol in tissues with phospho-6-tungstic-12-molybdic acid.


An automated method for the measurement of plasma hemoglobin.


A new specific assay for urinary creatinine.


An improved spectrophotometric method for determination of total 3-methoxy-4-hydroxyphenylglycol in urine.


Automated determination of free amino groups in serum and plasma using 2,4,6-trinitrobenzene sulfonate.


A rapid and simple thin-layer chromatographic method for amino acids in blood.


Infarction of the left hemicolon due to primary vascular occlusion.


Purification and some properties of leucyl-tRNA synthetase from Bacillus stearothermophilus.


Viability of cancer cells penetrating tissues during operations for cancer of the rectum.


Studies on the mechanism of galactosamine-1-phosphate and its inhibition of UDP-glucose pyrophosphorylase.


Bromothymol blue and bromocresol purple as indicators of pH changes in chromatophores of Rhodospirillum rubrum.


Perianal abscess as a presenting sign of leukemia.


Ternary complexes in solution. The stability increasing effect of the imidazole group on the formation of mixed Cu2+ complexes.


Colorectal cancers in Jamaica: a review (1958-1967).


The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Determination and function of thiol groups.


The use of intralesional triamcinolone hexacetonide in treatment of idiopathic pruritus ani.


The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Molecular properties.


A diagnostic approach to chronic diarrhea.


On the biosynthesis of cyclopenin and cyclopenol, benzodiazepine alkaloids from Penicillium cyclopium Westling.


Tube cecostomy--an appraisal.

Tube cecostomy--an appraisal.


Circular dichroism of bovine plasma albumin--dye complexes.


Cryosurgical hemorrhoidectomy: preliminary report.


Extended theory of polarized fluorescence for uniaxial orientation and non-coinciding absorption and emission vectors.


Optical properties of oriented dye-LiDNA complexes prepared with the wet spinning method.


Deductions regarding the pull-through operation, based on subjective reactions described by the patients.


Steroids in newborns and infants. C19 and C21 steroids in faeces from infants.


The conversion of N-formyl-L-aspartate into nicotinic acid by extracts of Clostridium butylicum.


Enzymes involved in fructose metabolism in lir and the glyceraldehyde metabolic crossroads.


Beef pancreas tryptophanyl-tRNA synthetase. Molecular weight, composition and spectral properties.


Central Service. Disposability as a technic.


Evaluating preceptorship training programs.


Hospital and community join in diabetic education program.


Reviewing job content to improve personnel utilization.


Better telephone services achieved, costs reduced with new system.


Professionalism in administration.

Professionalism in administration.


Focus on management methods. Now--meet the "soft-core".


Review of hospital lawsuits. Employee liability for contracts.


The wage assignment: a personnel problem.


Dialysis center trains families to treat patients at home.


Housekeepers are challenged to 'preserve for tomorrow'.


Students get clinical experience in pharmacy clerkship program.


Intensive care for high-risk infants provided in special newborn unit.


All private room design saves space, frees staff time.


Positive zoning requirements can help meet demands for expanded health services.


The challenge of hospital public relations. 1. A plan for professionalism.


Patient information system utilizes central dictation system.


Materials management. Special discounts can produce big savings.


Penetration of surgical draping material by bacteria.


Inventory control in the dietary department.


Nursing service. The change of shift report: study sows weaknesses, how it can be improved.


Computer-assisted cost accounting in the dietary department.


Loss of mouse virulence in Chikungunya virus from the carrier culture of Aedes albopictus cell line.


The distribution of some serum protein and enzyme group systems in two endogamous groups in S. India.


Anaemia in subacute toxicity with DDS in white rats.


Congenital anomalies of the human umbilical cord and their clinical significance: a light and electron microscope study.


Immuno-electrophoretic characterization of brucella antigens: I-sonic extracts.


Serum lactic dehydrogenase and its isoenzymes in myocardial infarction.


Effect of hormones on embryonic bone rudiments cultivated in vitro. II. Effect of progesterone.


Thyroidal handling of radioiodine during fasting.


In vitro incorporation of C14-leucine by livers and uteri of protein depleted rats.


The anorexient activity of Kalio-kund (Dioscorea bulbifera Linn.), methylphenidate and cocaine in rats: a preliminary study.


Studies in stress induced changes on rat's adrenals. I. Effect of central nervous depressants.


Studies in stress induced changes on rat's adrenals. II. Effect of pre-treatment with steroids.


Studies in stress induced changes on rat's adrenals. 3. Effect of pre-treatment with ascorbic acid.


Annanase induced degenerative arthritis and the effect of an indigenous drug.


Head injury peculiar to crude cane-crusher: 'Kohlu' injury.


The significance of vascular complications, blood lipid alterations and I-131-lipid tolerance test in diabetes mellitus.


A micro method for hydroxyproline estimation.


Shanker H, Uberoi IS: Nutritional and anthropometric progile of young rural Punjabi children.


Serological response in humans to a formolized Kyasanur Forest disease vaccine.


Isolation of Ganjam virus from a human case of febrile illness: a report of a laboratory infection and serological survey of human sera from three different states of India.


Identification of the genus Klebsiella: some observations on morphological and biochemical characters and the decarboxylase reactions.


Lysine iron agar medium in routine diagnostic enteric bacteriology.


The crystal and molecular structure of N-methyl-N-t-butyl-3-hydroxyazetidinium methanesulfonate, a nonplanar azetidinium ring.


The crystal and molecular structure of L-azetidine-2-carboxylic acid. A naturally occurring homolog of proline.


The synthesis and certain pharmacological properties of deamino-oxytocinoic acid methylamide and deamino-oxytocinoic acid dimethylamide.


An unusual reaction of skatole with tetranitromethane.


Preparation and properties of crystalline permanganic acid.


Immediate improvement of sensation on relief of extraneural compression.


Arthrography in the rheumatoid wrist joint. A preliminary report.


Pollex abductus due to congenital malposition of the flexor pollicis longus.


Opponensplasty using the extensor digiti minimi.


Correction of the rheumatoid boutonnière deformity.


Transfer of extensor carpi ulnaris to tendon of extensor pollicis brevis for opponensplasty.


Reconstitution of vertebral height in histiocytosis X: a long-term follow-up.


Tyrosine at the active centre of ornithine carbamyltransferase.


The effect of actinomycin on RNA synthesis and phosphate uptake in isolated castor bean cotyledons. A tentative evaluation of the half-lives of mRNAs for some enzymes.


Destructive lesions of the spine in rheumatoid ankylosing spondylitis.


The manifestations of arrested bone growth--the appearance of a vertebra within a vertebra.


Structure of membrane. V. Sphingomyelin detection by immune reaction on the surface of sheep erythrocytes.


Unilateral spondylolysis of the sixth cervical vertebra.


Comparative kinetics and autoradiography of 45Ca and 133Ba in ten-year-old beagle dogs. The diffuse component distribution throughout the skeleton.


Osteomyelitis of the sesamoid bones of the first metatarsophalangeal joint.


Pistol-grip conversion of air drill.

Pistol-grip conversion of air drill.


Modification of Mitchell's lateral displacement angulation osteotomy.


Letter to the editor: commentary on recent article "Electromyographic diagnosis of lumbar disc disease". Discussion.


The effect of cyclophosphamide on experimental allergic encephalomyelitis in rats.


An allergist looks at chronic disease.

An allergist looks at chronic disease.


Current concepts of the asthmatic child's adjustment and adaption to institutional care.


Rice pollen asthma.

Rice pollen asthma.


Water permeability in resting and stimulated crayfish nerve. The hydraulic conductivity, L(p), was determined in single axons of the crayfish, Procambarus clarkii, by injecting a hypertonic sample between two drops of silicone oil and photographing the volume increase of the sample. The method has the advantage of minimizing errors due to hydrostatic pressure differences across the membrane. In resting axons an L(p) of 0.236 x 10(-8) cm/ sec per cm H(2)O was found and similar values were obtained with low external calcium concentration and when the nerve was continuously stimulated at 20-30 impulses/sec. Thus the experiments have failed to demonstrate any change of water permeability in cases in which the ionic conductance is known to change. Some possible implications of this are discussed.


Sodium transport in turtle erythrocytes. Apparent stimulation of exchange diffusion by anaerobiosis. Studies were performed on Na and K transport by red blood cells of the freshwater turtle under anaerobic and aerobic conditions. Although it had previously been assumed that cation transport in turtle red blood cells was dependent on respiration, the present data show greater Na efflux rates in N(2) than in O(2). However, ouabain inhibited Na transport by the same amount quantitatively in O(2) and N(2) gas phases. Thus there was no difference in ouabain-sensitive or "pump" Na transport rates. Na influx rates were higher in nitrogen than in air and potassium influx rates were not significantly different under aerobic and anaerobic conditions. Moreover in the absence of sodium in the bathing medium no difference between air and nitrogen could be discovered. Finally with ethacrynic acid plus ouabain there was an additional decrease in Na efflux but there was a persisting difference between air and nitrogen. These studies do not rule out the existence of a ouabain-insensitive ethacrynic acid-inhibitable flux; however, they suggest that at least part of the activation of Na efflux observed in N(2) was due to increased exchange diffusion.


Differences between pacemaker and nonpacemaker neurons of Aplysia on voltage clamping. The responses of pacemaker and nonpacemaker Aplysia neurons to voltage clamp commands of less than 200 msec duration are essentially identical. For moderate depolarizing commands there is an early inward transient current followed by a late outward current and an outward tail current when the membrane is clamped back to resting potential. On long (1-2 sec) commands in pacemakers there is a marked sag in the late current and an inward tail current. E(tail), the potential of the membrane at which there is no net current flow under the conditions prevailing at the end of the clamp, shifts from about -9.0 mv on short commands to +5.0 mv on long commands. In contrast there is no marked sag of the late current or inward tail current on long commands in nonpacemakers, and E(tail) is near -9.0 mv for both short and long commands. The current sag and shift in E(tail) can be ascribed to a decreased conductance (presumably to K(+)) at the end of the long as compared to the short command in half of the pacemaker neurons. In the remaining cells the essential difference from nonpacemakers appears to be either a greater restricted extracellular space or a more active potential-dependent electrogenic Na(+) pump in pacemakers.


Calcium exchange and contraction strength of guinea pig atrium in normal and hypertonic media. A Krebs-Henseleit (KH) medium made hypertonic by adding nonpermeant molecules substantially increased the isometric peak tension at steady-state contractions below 3 per sec in guinea pig atrium at 27 degrees C. Action potential durations were decreased. KH plus 100 mM raffinose or sucrose resulted in similar and nearly maximal changes which were essentially reversible upon return to normal KH. When one active contracting atrium was used to passively stretch a second atrium, the difference in Ca ion exchange (1 min exchange with the extracellular space) between active and stretched atria significantly increased at 1 per sec and at 2 per sec in going from normal to 100 mM hypertonic KH. The calculated mean Ca ion cellular exchange per beat per 100 g of cells (a) doubled in changing from normal to 100 mM hypertonic KH, and (b) decreased slightly in changing from contractions of 1 per sec to 2 per sec in normal KH. These data are consistent with the hypothesis (a) that Ca ion entry per beat from the extracellular space is proportional to membrane depolarized time with a constant medium and a steady-state condition, and the hypothesis (b) that 100 mM hypertonicity doubles the Ca ion entry rate during depolarization. These data enable rejection of the hypothesis that the peak tension is proportional to the Ca ion entry per beat from the extracellular space under steady-state conditions, and suggest that any additional Ca ion involved in the larger contractions at higher frequencies comes from an increase in Ca ion available from intracellular stores.


Reversal of ouabain-induced inhibition of human eccrine sweat gland function by diphenylhydantoin.


Analysis of the effects of calcium or magnesium on voltage-clamp currents in perfused squid axons bathed in solutions of high potassium. Isolated axons from the squid, Dosidicus gigas, were internally perfused with potassium fluoride solutions. Membrane currents were measured following step changes of membrane potential in a voltage-clamp arrangement with external isosmotic solution changes in the order: potassium-free artificial seawater; potassium chloride; potassium chloride containing 10, 25, 40 or 50, mM calcium or magnesium; and potassium-free artificial seawater. The following results suggest that the currents measured under voltage clamp with potassium outside and inside can be separated into two components and that one of them, the predominant one, is carried through the potassium system. (a) Outward currents in isosmotic potassium were strongly and reversibly reduced by tetraethylammonium chloride. (b) Without calcium or magnesium a progressive increase in the nontime-dependent component of the currents (leakage) occurred. (c) The restoration of calcium or magnesium within 15-30 min decreases this leakage. (d) With 50 mM divalent ions the steady-state current-voltage curve was nonlinear with negative resistance as observed in intact axons in isosmotic potassium. (e) The time-dependent components of the membrane currents were not clearly affected by calcium or magnesium. These results show a strong dependence of the leakage currents on external calcium or magnesium concentration but provide no support for the involvement of calcium or magnesium in the kinetics of the potassium system.


Cells containing Langerhans granules in human lymph nodes of dermatopathic lymphadenopathy.


Dopa and the red, brown and black pigments of hair and feathers.


Failure of lathyrism to affect the solubility properties of keratins from the scales and beaks of embryonic chickens.


The ultrastructure of the cornea-lens epidermis in the lateral eye of Limulus polyphemus.


Oocyte-follicle cell differentiation in two species of amphineurans (Mollusca), Mopalia mucosa and Chaetopleura apiculata.


The descriptive use of neighborhood limited classification in functional morphology: an analysis of the shoulder in primates.


Ultrastructure of thymic myoid cells.

Ultrastructure of thymic myoid cells.


Cytochemical and fine structural analysis of oogenesis in the gastropod, Ilyanassa obsoleta.


Inactivation of bacteriophage lambda containing semiconserved alkylated deoxyribonucleic acid. Immediate and delayed inactivation of ethylmethane sulfonate (EMS)-treated lambda phage were studied. Phage particles with one alkylated and one intact deoxyribonucleic acid (DNA) strand were obtained by allowing host-modified, EMS-treated phage to undergo one growth cycle in a nonmodifying host and selecting the progeny with semiconserved parental DNA on a restricting host. The results indicate that particles with one alkylated DNA strand are more sensitive to a second treatment with the alkylating agent. When incubated at 37 C, they are subject to inactivation at a rate which is smaller than that of phages containing two alkylated DNA strands. It appears that depurination events in one of the DNA strands of a phage particle are sufficient to cause death.


Chromatography of arbovirus ribonucleic acid forms on columns of benzoylated-diethylaminoethyl cellulose. Benzoylated-diethylaminoethyl cellulose (BD-cellulose) column chromatography was found to be useful in resolving most of the ribonucleic acid (RNA) forms from the replicative cycle of group A arbovirus Semliki Forect virus (SFV). The elution patterns were independent of molecular weight and appeared to be related to the degree of secondary structure in the molecule. Fractions of RNA were taken from a sucrose density gradient of cytoplasmic extracts of SFV-infected chick cells pretreated with actinomycin D. In a linear salt gradient, 16S material cochromatographed with the rapidly eluted ribonuclease resistant core of the double-stranded SFV-RNA and with the homopolymer duplex polyinosinic acid: polycytidylic acid. This fraction, therefore, probably contains an SFV-RNA form similar to the completely double stranded replicative form (RF) of several RNA viruses and bacteriophages. Faster moving (>20S) sucrose gradient fractions eluted more slowly, suggesting a decreasing proportion of secondary structure with increasing sedimentation value. The fractions, therefore, seemed to contain replicative intermediate (RI) structures. The two single stranded forms of SFV-RNA (42S and 26S) could only be eluted from BD-cellulose in the presence of urea or dimethyl sulfoxide, suggesting the presence of minimal secondary structure. Under these conditions, the single-stranded viral RNA forms could not be resolved. Molecular sieve chromatography of the single-stranded RNA forms, performed by passage through an agarose column, also failed to resolve these forms. The viral RNA forms containing a high degree of secondary structure, probably the RF and the RI, could, therefore, be rapidly separated from each other and from the single-stranded forms.


Proteins of Newcastle disease virus and of the viral nucleocapsid. Newcastle disease virus was found to contain three major proteins. The structure unit of the viral nucleocapsid appears to be monomeric and to consist of a single large protein of an approximate molecular weight of 62,000.


Phi-X-174 bacteriophage structural mutants which affect deoxyribonucleic acid synthesis. Seven cistrons in phiX-174 were identified and one in particular was studied intensively: cistron A, which is assigned a protein in the mature phage. Amber mutants in this cistron synthesize a new deoxyribonucleic acid (DNA) form in addition to circular phage DNA upon infection of the restrictive host. This DNA is linear, non-infectious, and single-stranded; it is formed from the phage strand of replicative form phiX-174 DNA. These mutants produce two different defective particles in the restrictive host. One particle contains circular phage DNA but is not infectious; the other contains the new DNA form and is similar to the 70S particles found in wild-type phage lysates. The mutant A gene product acts independently of normal A protein upon mixed infection of the restrictive host with an A mutant and a mutant from any other cistron or wild type.


Synthesis of vaccinia viral proteins in cytoplasmic extracts. I. Incorporation of radioactively labeled amino acids into polypeptides. Polypeptide synthesis has been studied in cell-free systems prepared from vaccinia virus-infected and uninfected HeLa cells. Cytoplasmic extracts containing endogenous messenger ribonucleic acid were used. Amino acid incorporation into hot trichloroacetic acid-precipitable material was linear for 15 to 20 min at 37 C. The initial rate of protein synthesis was approximately 15% of the rate in intact cells. Optimal conditions for polypeptide synthesis were similar in cell-free systems prepared from infected or uninfected cells. Requirements for an energy source and Mg(++) were demonstrated. The optimal Mg(++) concentration was 4 to 5 mm. Ribonuclease, puromycin, and cycloheximide were inhibitory. The molecular weights of the polypeptides labeled in the cell-free systems, as determined by gel filtration in 5 m guanidine hydrochloride, ranged from 16,000 to above 68,000. Polyacrylamide gel electrophoresis indicated that the polypeptides labeled in cell-free extracts of uninfected and infected cells were different. The latter closely corresponded in electrophoretic mobility with the viral polypeptides made in intact, infected cells.


Biochemical studies on adenovirus multiplication. XVI. Transcription of the adenovirus genome during abortive infection of elevated temperatures. The synthesis of infectious virus is reduced by 99% in adenovirus type 2-infected KB cells maintained at 42 C in suspension. Studies to delineate the steps in virus biosynthesis blocked at 42 C revealed the following. (i) The inhibition of ribosomal ribonucleic acid (RNA) synthesis and the block in the conversion of ribosomal RNA precursors to ribosomal RNA which normally occur in infected cells at 37 C was accentuated at 42 C. (ii) The same species of early and late viral messenger RNA were synthesized at 37 and 42 C. (iii) The shift from host cell deoxyribonucleic acid (DNA) synthesis to viral DNA replication occurred earlier at 42 C than at 37 C. These findings indicate that the thermosensitive block(s) in virion formation does not occur at the level of viral DNA replication or transcription of viral mRNA but probably involves the synthesis of late viral proteins or the maturation of the virion.


Morphogenesis of Venezuelan equine encephalomyelitis virus. Morphogenesis of Venezuelan equine encephalomyelitis virus was studied by means of electron microscopy. Virus-specific structures (factories, viroplasts) were found at early stages of infection; these structures were composed of fibrillar and cylindrical formations, aggregates of ribosomes, and viral nucleoids. The latter emerged from fibrillar and cylindrical structures. Aggregates of viral nucleoids were found in the cytoplasm and occasionally in the nuclei of virus-infected cells. Viral envelopes and mature virions were formed on the cell membranes and on the membranes of intracellular vacuoles. Anomalous forms of virions (both polygenomic and oligogenomic) were observed.


Properties of 42S and 26S Sindbis viral ribonucleic acid species. Two species of ribonuclease-sensitive Sindbis viral ribonucleic acids which sedimented at 42S and 26S were studied. 42S RNA, derived either from virions or from viral nucleoids extracted from infected cultures, was converted by heating to an RNA which sedimented at 26S. The sedimentation patterns of 42S RNA and "derived" 26S RNA were similarly affected in low ionic strength buffers. 42S RNA ran as a homogeneous fraction on polyacrylamide gels; the "derived" 26S RNA as well as "natural" 26S RNA from infected cultures showed similar electrophoretic patterns of heterogeneity. A doubling of 3' polynucleotide termini was observed when 42S RNA was heated. Two possibilities concerning the structure of 42S RNA are considered. (i) It may consist of an aggregate of subunits, joined by means of hydrogen bonds to form a complex molecule. (ii) A heat-labile covalent bond of unknown type may link viral RNA subunits. Although 26S RNA from infected cultures and "derived" 26S RNA from 42S RNA behaved in a similar qualitative manner on gels, their sedimentation characteristics were affected differently in low ionic strength buffers. "Natural" and "derived" 26S RNA appear to consist of a population of fragments. and their behavior in gradients and in gels is probably dictated by the experimental conditions of the analytical methods used.


Effect of antibody to neuraminidase on the maturation and hemagglutinating activity of an influenza A2 virus. Antiserum to a recombinant between an A(o) and an A(2) influenza virus had no detectable antibody against an A(2) virus in standard hemagglutination-inhibition tests, and inhibited 95% of viral neuraminidase activity at a 1 to 400 dilution. However, on mixing virus with antiserum, a drop of up to 90% in hemagglutinin titer was observed. The effects of ultrasonication and direct electron microscopic examination indicated that the antiserum caused aggregation of virus particles. When antiserum was added to A(2) virus-infected chick embryo fibroblasts, release of virus appeared markedly inhibited. After ultrasonication to disrupt aggregates, an increase in released hemagglutinin was observed, but the resulting level was considerably lower than that in control cultures containing normal rabbit serum. In thin sections of infected cells, similar numbers of virus profiles were observed in control and antiserum-treated cultures. A marked increase in release of hemagglutinin was noted if receptor-destroying enzyme was added to antiserum-treated cultures. The results indicate that antibody to neuraminidase does not exert a direct effect on viral maturation, but inhibits the detachment of viral progeny from cell surface receptors.


Factors influencing virulence and plaque properties of attenuated Venezuelan equine encephalomyelitis virus populations. A minority of stable large-plaque virus increased proportionally in stored unstable attenuated (9t) Venezuelan equine encephalomyelitis virus populations. L-cell-grown progeny (9t2) of stored 9t showed large amounts of large-plaque virus and increased virulence. Small-plaque virus inhibited large-plaque virus but not the reverse. Serial passage of small-plaque virus from 9t2 yielded a strain (20t) that was more attenuated than 9t.


Temperature-sensitive behavior of hemagglutinin in a temperature-sensitive mutant virion of Sindbis. The hemagglutinating ability of a temperature-sensitive mutant virion was reversibly lost when the temperature of hemagglutination was increased from 27 to 37 C.


A digital computer model of the effects of gravitational stress upon the heart and venous system.


Velocity dispersion in skeletal muscle efferent nerve bundle and its effect upon time and frequency response.


Hazards in the use of low frequencies for the measurement of physiological events by impedance.


A study of the automation of cytodiagnosis.


A programmed reaction timer for psychological research.


Relationship between weight loss and venous and dialysate pressures during chronic intermittent haemodialysis.


Six-electrode method for the measurement of the passive electrical properties of brain envelopes.


An apparatus for measuring startle response and motor activity in rats.


Stimulation triggered automatically by electrophysiological events.


Optoelectronic transducer for intravascular measurements of pressure variations.


Intensity modulation of ink-jet oscillographs.


The shape conforming electrode.

The shape conforming electrode.


Public health engineering in the Third World.


Teaching and scientific research.

Teaching and scientific research.


Extra-neuronal sodium store in central nervous system of Anodonta cygnea.


Automatic gain control model for vision.


Multiplexer unit for controlled infusion of fluids.


Development and use of the POD catheter in the cerebral vascular system.


Interspecies constancy of N-terminal amino-acid sequences in the gamma-chain of fibrinogen.


Effect of growth hormone on skeletal mass in adult dogs.


Constitution and physical chemical properties of intramuscular connective tissue.


Beta-ray split dose recovery in diploid yeast in hypoxic conditions.


An efficient indirect drop transducer.

An efficient indirect drop transducer.


Myocardial lesions: a reassessment of the toxicology of calcium cyclamate.


Metabolic rates during recovery from protein-calorie malnutrition: the need for a new concept of specific dynamic action.


A device for objective indirect recording of the arterial pressure and related data.


Development of pulsating embryos from rabbit blastocysts cultivated in vitro.


Glutamate sensitivity of denervated insect muscle fibres.


A defense of electrical impedance plethysmography. Comments on a paper Electrical impedance plethysmography: a critical analysis.


Positive feedback and health-care costs.


A comparison of coherent averaging techniques for repetitive biological signals.


Microinjection of ouabain into crab muscle fibres.


Dichromacy in the ground squirrel.

Dichromacy in the ground squirrel.


Increase in plasma turbidity as a result of cerebral stimulation.


BRL 1288-a new anti-Parkinson drug.

BRL 1288-a new anti-Parkinson drug.


Children's size judgments in a picture with suggested depth.


Functional significance of the sympathetic nervous system in production of hypertension.


Evidence for a positive relationship between degree of control acquired by two dimensions of a complex stimulus.


Brain response correlates of psychometric intelligence.


The computer and individualized instruction.


Trypsin and papain covalently coupled to porous glass: preparation and characterization. Trypsin and papain have been covalently linked to porous glass particles. The resulting insolubilized enzymes show increased thermal stability and can be employed for extended periods of time without loss of activity.


Artificial placenta: two days of total extrauterine support of the isolated premature lamb fetus. A premature lamb fetus was totally sustained by extracorporeal perfusion with the use of a silicone-membrane blood oxygenator and parenteral nutritional support. The fetus remained in a metabolically stable state lasting several days.


Carcinogen-induced immune depression: absence in mice resistant to chemical oncogenesis. Administration of 3-methylcholanthrene 6 days before antigenic challenge depressed the immune response to sheep red cells in young adult mice (C3Hf/Bi strain) sensitive to the oncogenic effect of the drug (100 percent local tumors 240 days after carcinogen). The drug was not immunodepressant in the I strain, which is relatively resistant to its carcinogenic effect (11 percent local tumors 240 days after carcinogen).


Thrombin-induced release of calcium from blood platelets.


Postsynaptic inhibition: intracellular effects of various ions in spinal motoneurons. Long-lasting depolarizing shifts of the electromotive force of post-synaptic inhibition occurred after tracellular injection of ammonium ions, basic amino acids, hydrogen ions, and some bivalent heavy-metal ions. These substances act on specific postsynaptic membrane sites.


Phosphorylation of dipteran chromosomes and rat liver nuclei. Side-chain modifications of the nucleoproteins are believed to be involved in the control of gene function. Rat liver nuclei and chromatin incubated in adenosine triphosphate labeled in the gamma position with phosphorus-32 demonstrated rapid phosphorylation in vitro of the nuclear proteins. Dipteran salivary glands incubated in either labeled adenosine triphosphate or ortho-phosphate labeled with phosphorus-32 showed that there is phosphorylation of chromosomal protein. The phosphorus is associated in protein from both liver and salivary gland nuclei predominantly with phosphoserine.


Alcohol metabolism: role of microsomal oxidation in vivo. A role for microsomal alcohol oxidation cannot be demonstrated in vivo. Factors affecting microsomal drug hydroxylations had no effect on alcohol metabolism in the rat in vivo. The compound SKF 525-A which inhibits, and chronic phenobarbital treatment which enhances microsomal drug hydroxylations did not alter alcohol oxidation.


Axonal outgrowth and cell migration in vitro from nervous system of cockroach embryos. Brain and ganglia of embryonic Periplaneta americana were grown for 2 to 3 weeks in a chemically defined medium. Nerve fibers sprouted vigorously from intact brains and ganglia, interconnecting nerve cultures, and adjacent cultures of the digestive tract, Glia, tracheal, and nerve cells were present in large numbers in the migratory zone surrounding the explants.


Seawater teleosts: evidence for a sodium-potassium exchange in the branchial sodium-excreting pump. The net sodium extrusion rate by the gill of the seawater-adapted euryhaline flounder is identical to the potassium influx. The excretion of sodium is blocked in K(+)-free seawater solutions. The instantaneous sodium outflux readjustment pattern of flounders transferred from seawater to solutions of various sodium chloride or potassium chloride concentrations is consistent with the hypothesis of a linkage between Na(+) outflux and K(+) influx through a common exchange carrier. External Na(+) and K(+) compete for this comnmonz carrier. It is suggested that the exchange diffusion mechanism (linkage of sodium influx and outflux) and the high internal sodium turnover rate which characterizes all seawater teleosts are the results of this competitive process. The sodium-potassium dependent adenosine triphosphatase system occurring in the gill of the seawater teleosts may play a central role in this sodium-potassium exchange pump.


Cortisol induction of growth hormone synthesis in a clonal line of rat pituitary tumor cells in culture. Growth hormone synthesis increased markedly after addition of glucocorticoids at physiological concentrations to cultures of the GH(1) line of rat pituitary tumor cells. Stimulation of hormone protein synthesis by corticosteroids was selective, since (i) the rate of hormone synthesis increased while total protein synthesis decreased, and (ii) cortisol analogs, biologically inactive metabolites, and sex steroids did not induce growth hormone synthesis.


On the incidence of cranio-cervical injuries.


Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat. With spontaneous activity as a measure of arousal, dose response curves were established for scopolamine and amphetamine administered to 10-, 15-, 20-, 25-, and 100-day-old rats. Amphetamine always increased activity, but scopolamine had no efect on younger rats, which suggests that adrenergic excitatory areas in the brainstem mature more rapidly than cholinergic inhibitory areas in the forebrain.


The natural history of the subacute sclerosing encephalitis.


Dendritic spikes revisited.

Dendritic spikes revisited.


Primary brain stem injury.

Primary brain stem injury.


Carotid artery thrombosis in non-penetrating injuries of the head and neck.


Cable theory and gross potential analysis.


Conservative and operative treatment of 240 lumbar disc lesions.


Gene regulation in higher cells.

Gene regulation in higher cells.


Marihuana and simulated driving.

Marihuana and simulated driving.


Reactors and the public good.

Reactors and the public good.


Extraspinal ependymoma.

Extraspinal ependymoma.


Chemicals and cancer.

Chemicals and cancer.


Epilepsy in ayurveda.

Epilepsy in ayurveda.


A case of muscular dystrophy with probable lipoma of the corpus callosum.


Some mathematical models in science.

Some mathematical models in science.


The population crisis: rising concern at home.


Medical schools: at the center, the problem is unreimbursed costs.


Serum cholesterol reduction by chromium in hypercholesterolemic rats. The addition of chromium (III) to the drinking water of rats in a normal laboratory environment on a hypercholesterolemic diet resulted in lower serum cholesterol concentrations whether the dietary carbohydrate was either sucrose or starch. However, rats fed the sucrose diet with chromium in drinking water had serum cholesterol concentrations similar to those of rats fed the starch diet without chromium in drinking water.


Calibrated membranes with coated pore walls. Extremely uniform small-radius pores, formed in thin mica membranes, have been coated with monoand multimolecular layers of fatty acids. Stearate monolayers orient themselves on the pore walls in layers 25 to 28 angstroms thick. The resulting membranes, with radii of the order 100 angstroms or less, may have applications in simulating certain features of biological membranes and in fabricating highly selective membranes for differential dialysis or ultrafiltration.


Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice. Neonatal thymectomy of mice, when no ectopic thymus existed, constantly resulted in developmental arrest of the ovary but not of the testis; it also caused sterility in the female. The ovaries of thymectomized mice were extremely small and were characterized by absence of follicles and corpora lutea. Such an ovarian dysgenesia was observed when the mice were thymectomized at 3 days of age, but not at 7 days or later; it was prevented by thymus grafting.


Berberine: complex with DNA.

Berberine: complex with DNA. A complex of calf-thymus DNA with berberine sediments in the analytical ultracentrifuge. The DNA produced systematic changes in the absorption spectrum of berberine which suggest that single alkaloid molecules bind to DNA. Flow dichroism of purines and pyrimidines and of berberine in the complex with DNA had the same signs and magnitudes. Berberine shifted the thermal strand separation profile of DNA to higher temperatures. Therefore, the alkaloid forms a complex with DNA, probably by intercalation.


Fungal endogenous rhythms expressed by spiral figures. Culture zonations in two fungi, Nectria cinnabarina and Penicillium diversum, are expressions of endogenous rhythms. These culture zonations may take the form of either concentric rings or Archimedes' spirals. The rhythm in N. cinnabarina is noncircadian. The rhythm in P. diversum is relatively insensitive to temperature and has a period of approximately 24 hours. The lack of a demonstrable mechanism for phase shifting suggests that this rhythm may also be noncircadian.


Parasexual cycle in cultivated human somatic cells. Somatic segregation for three different autosomes was demonstrated in two strains of human diploid fibroblasts derived from subjects known to be heterozygous for chromosomal variants. Recombinant diploid cells appeared within cultures of tetraploid clones isolted from mass cultures. Tetraploid cells regularly occur in mass cultures and within clones of diploid cells. Such a parasexual cycle (2n-->4n-->2n), with recombination of entire linkage groups, could from the basis of a beginning formal genetic analysis in man.


Thiamine release from nerve membranes by tetrodotoxin. Tetrodotoxin (3 x 10(-8) molar) promoted the release of thiamine from perfused rat and frog nerve preparations in a manner similar to other neuroactive drugs. When the rats were injected with thiamine labeled with sulfur-35, analyses of brain, spinal cord, and sciatic nerve homogenates revealed labeled thiamine in membrane, synaptosomes, and mitochondrial subfractions. However, on incubation of these fractions with tetrodotoxin, thiamine was released only from the membrane fragments.


Phenylalanine and tyrosine synthesis under primitive earth conditions. Phenylacetylene can be synthesized in substantial yields from various hydrocarbons by high temperatures, electric discharges, and ultraviolet light. Phenylacetylene is hydrated to phenylacetaldehyde by way of both nucleophilic and radical additions of H(2)S followed by hydrolysis of the thtioaldehyde. The addition of NH(3) and HCN to phenylacetaldehyde yields phenylalanine nitrile which is hydrolyzed to phenylalanine. A small yield of tyrosine is obtained from the radical addition of H(2)S to phenylacetylene. This sequence of reactions is a possible mechanism for the synthesis of these amino acids on the primitive earth.


Positive instances of reinstatement.

Positive instances of reinstatement.


Evoked potentials: modifications by classical conditioning. Visual evoked potentials to a positive discriminative stimulus change systematically during sensory conditioning and extinction. Changes due to conditioning are manifested in the increased amplitude of the late component of the evoked response. This effect is attenuated during extinction and reappears after reconditioning.


Bacteremia and bacteremic shock in surgical patients.


The critcally ill patient with renovascular hypertension.


Postoperative respiratory failure.

Postoperative respiratory failure.


Cardiac arrhythmias in the postoperative patient.


Management of the seriously ill patient with an ischemic extremity.


Management of renal insufficiency in surgical patients.


Acute postoperative peptic ulceration.

Acute postoperative peptic ulceration.


Some adverse drug reactions common in the postoperative period.


Isoimmunization: a growing problem in transfusion of the surgical patient.


The fat-embolism syndrome.

The fat-embolism syndrome.


Treatment of the patient with severe tetanus.


Neonatal intestinal obstruction: the challenge of minutiae.


Pinniped origins and the rate of evolution of carnivore albumins.


Massive bleeding of colonic origin.

Massive bleeding of colonic origin.


Serological data and phylogenetic inference: th problem of rates of change.


Growth of postimplantation mouse embryos cultured in a serum-supplemented, chemically defined medium.


Acute mediastinitis.

Acute mediastinitis.


Management of patients with enterocutaneous fistulas.


Resorption in guinea pigs as estimated by counting corpora lutea: the problem of twinning.


Correlation of embryonic movement with palate closure in mice.


Fetal weight and intrauterine position in rats.


Studies of the growth-inhibitory action of cortisone on chick embryos.


Primary structure of two oligopeptides of the toxin of Bombina variegata L.


Properties of leptinotarsin. A toxic hemolymph protein from the Colorado potato beetle.


Effect of aflatoxins on rat liver lysosomes.


Samandinine, a minor alkaloid from Salamandra maculosa Laur.


Species defferences in susceptibility to elapid venoms.


Effect of Loxosceles reclusa Gertsch and Mulaik venom on Heliothis virescens (F.) larvae.


Study of hemolysis in the lethal effect of Naja naja venom in the mouse and guinea pig.


Abnormal bile duct epithelium in liver biopsies with histological signs of viral hepatitis.


Thymic dysplasia with immunological deficiency. Report of two unusual cases.


Hyaline microthrombi in an autopsy material. A quantitative study with discussion of the relationship to small vessel thrombosis.


The involution of the foetal adrenal cortex. A light microscopic study.


The cytotrophoblastic cell columns and the cell islands of the normal human placenta. A light and electron microscopic study with particular reference to the nature of the intercellular material.


Histological and histochemical study of the extracellular deposits in the normal human placenta.


Reversible and irreversible LDH isoenzymatic alterations in malignant and non-malignant murine tissues during cultivation. A correlation between tumour morphology and isoenzyme structure.


Corroding and spreading colonies in Moraxella nonliquefaciens.


Sarcoidosis. An in vitro Kveim reaction based on the leucocyte migration test.


Oral contraceptives and cervical cancer. A preliminary report of an experimental study.


Non-homogeneous wash-out conditions of Xenon-133 from adipose tissue.


Brown fat thermogenesis reflected in mitochondrial respiration.


Release, reuptake and net uptake of dopamine, noradrenaline and adrenaline in isolated sheep adrenal medullary granules.


Hypoxia and pulmonary vascular resistance. The relative effects of pulmonary arterial and alveolar PO2.


Arteriovenous anastomoses in temperature regulation.


Intercostal and cerebellar influences on efferent phrenic activity in the decerebrate cat.


Short-term habituation and dishabituation of the sensory evoked response in man.


The effect of noradrenaline on the direct cortical response of asphyxiated newborn rabbits.


Renal handling of galactose in the cat.

Renal handling of galactose in the cat.


pH-dependence of the mechanism in the duodenal bulb inhibiting gastric acid responses to exogenous gastrin.


Kininogen in plasma from cat, hamster and guinea-pig.


Mechanisms in the maintenance of glomerular filttion rate during high urine flow.


Electrical and mechanical activity in myometrial grafts in the rabbit.


Dissociation of histamine release and 22Na+ uptake in rat mast cells exposed to compound 48/80 in vitro.


Possible relation between the degree of cardiac adrenergic innervation and the resistance to hypothermic ventricular fibrillation in young cats.


Blood flow in the interdigital web of sea gull at low temperatures.


The dynamics of the inotropic change prduced by altered pacing of rabbit papillary muscle.


Blood flow through muscles during heavy rhythmic exercise.


Proximal tubular reabsorption in the rat kidney as studied by the occlusion time and lissamine green transit time technique.


Role of autoregulation in maintaining glomerular filtration rate at large urine flow.


On the mechanism of action for the effect of cholecystokinin on the choledochoduodenal junction in the cat.


Effects of growth hormone on amino acid transport and protein synthesis in the isolated working rat heart.


Sight and survival.

Sight and survival.


On 'the effecting of all things possible'.


Microspectrophotometric study of the compound rhabdom in the moth (Manduca sexta) eye.


Effect of metabolic inhibitors on the release of vasopressin in vitro.


The effect of cooling on liver metabolism.


Krogh's bicycle ergometer modified for eccentric exercise.


Living bone as an engineering material.

Living bone as an engineering material.


Adrenocortical responses to exposure to a subtropical climate.


Descending monosynaptic connexions to spinal border cells.


Cardiac output and coronary blood flow during steady state hypoxia.


GABA synthesis in rat hippocampus correlated to the distribution of inhibitory neurons.


Two inhibitory reflexes to the abdominal stretch receptors of the crayfish.


Influenceof prolonged overhydration and dehydration on vasopressin content and neurosecretory material in the hypothalamo-neurohypophysial system of rats.


Effect of smooth muscle contraction on aortic diameter and aortic baroreceptor activity.


Dysbarism: role of fat embolization to the lung.


Computerless automatic data reduction for electronystagmography.


Ouabain-sensitive carrier-mediated transport of glucose in the cerebral ventricles of cats.


Influence of colchicine axoplasmic transport of amine storage granules in rat sympathetic adrenergic nerves.


Respiratory mechanics with lower body negative pressure (LBNP). A simulation of the erect posture.


Embryological observations of the ductus arteriosus in the guinea-pig, rabbit, rat and mouse. Studies on closure of the ductus arteriosus. IV.


Changes in platelets and lipids in experimental aeroembolism and bends.


Effect of oxygen and umbilical cord clamping on closure of the ductus arteriosus in the guinea-pig and the rat. Studies on closure of theductus arteriosus. VI.


Interval at sea-level pressure required to prevent decompression sickness in humans who fly in commercial aircraft after diving.


A comparative study of K42 and Na24 movements during the cardiac cycle.


Activity responses to altered photoperiods.


Lamellar organization of hippocampal excitatory pathways.


Role of helmet loss in head injuries to USAF aircrews who ejected, 1963-1967.


Colour specific features of visual cortical responses in man evoked by monochromatic flashes.


Syncope among aircrew evaluated at the USAF School of Aerospace Medicine.


Provision of solar flare radiation information in support of supersonic transport operations. A review of developments.


The mutual influence of gastrin and secretin on the external pancreatic secretion in dogs.


Projections of low threshold join afferents to the cerebral cortex of the cat.


The disappearance of Xe133 and I-125 in the canine gastrocnemius muscle following vasoconstriction and asodilatation.


Water balance in the pupa of the silk moth, Antheraea pernyi.


Microcalorimetry of the processes of coagulation in normal conditions and after exposure to a constant magnetic field.


Animal breath data for estimating the exposure of humans to chlorinated hydrocarbons.


Some problems associated with the storage of asbestos in polyethylene bags.


Vinyl acetate: a study of chronic human exposure.


Cesium-137, lead-210 and polonium-210 concentrations in selected human tissues in the United States.


A method for the collection of air samples for analysis by gas chromatography.


The adsorption of aliphatic acetate vapors onto activated carbon.


Sampling airborne solids in ducts following a 90 degree bend.


Noise exposures in pulp and paper production.


Residence, age, race and related factors in the survival and associations with salivary tumors.


Antibodies to trachoma in eye secretions of Saudi Arab children.


Serologic responses of children after primary vaccination and revaccination against smallpox.


Antigenic response to influenza virus in man. I. Neutralizing antibody response to inactivated monovalent A2 vaccine as related to prior influenza exposure.


Range-finding toxicity data: List VII.

Range-finding toxicity data: List VII.


Use of expired air-carbon monoxide for carboxyhemoglobin determinations in evaluating carbon monoxide exposures resulting from the operation of gasoline fork lift trucks in holds of ships.


Antigenic response to influenza virus in man. II. Neutralizing antibody response to inactivated monovalent B vaccine, with observations on vaccine efficacy during a subsequent type B epidemic.


A new simian adenovirus serologically related to human adenovirus type 2 and a chimpanzee with "viral hepatitis".


The direct optical measurement of atmospheric air pollution.


Present status of labeling of materials in industry.


Maximum permissible concentrations for tritiated water and tritiated thymidine.


The use of disposable hypodermic syringes for collection of mine atmosphere samples.


The effect of atropine on gastric secretory patterns in response to rentagastrin, histalog and insulin.


Absorption studies following gastric surgery.


Preliminary report of a new technic evaluating pancreatic enzyme secretion.


Analytical guides. Ethylbenzene. Vapor phase chromatography method.


Hygienic guide series: mesityl oxide.

Hygienic guide series: mesityl oxide.


In vivo effects of potassium in relation to stenosing ulceration of the small bowel.


Report on unionization of hospital pharmacists and the American society of hospital pharmacists.


Atomic absorption spectrophotometry in water analysis.


False cancer of the intestine--the inflammatory polyp.


Estimation of drug absorption rates from blood concentration profiles.


Current trends in medical education and their impact on pharmacy.


Regulation of the sale of narcotics through hospitals and related institutions: monkey on our backs?


The radiopharmacist in nuclear medicine--preparation of technetium-99m human serum albumin macroaggregates.


Potassium penicillin G injection-(buffered).


Determination of purity of toluidine blue O by thin layer chromatography (TLC).


Some theoretical aspects of bulk compounding technology. II. Suspensions.


By a waterfall: "zone I and zone II phenomena" in obstructive lung disease.


Blood and organ studies of circulating lymphocytes in humans with normal leukocyte counts.


Antitumor drug toxicity: implications for response and for survival.


The circulatory response to lidocaine in experimental myocardial infarction.


Testosterone binding affinity (TBA): alterations produced by pathological and physiological states.


The effect on serum tocopherol levels of drug-induced decrease in serum lipids.


Ultracentrifuge. Some analytical and preparative uses in biomedical research. Commentary.


Automated colorimetric microdetermination of phenols by oxidative coupling with 3-methyl-2-benzothiazolinone hydrazone.


Quantification of seven tricarboxylic acid cycle and related acids in human urine by gas-liquid chromatography.


Fluorometric method for the determination of lapachol in serum.


Fluorescence determinatioof sub-parts per billion hydrogen sulfide in the atmosphere.


Determination of mercury in apples by spark source mass spectrometry.


Ultracentrifuge. Some analytical and preparative uses in biomedical research.


Some comments on self-assessment of psychiatric knowledge and skills.


Range of psychological functioning in "normal" late adolescents.


Medical specialty choice and personality. II. Outcome and postgraduate follow-up results.


Defining milieu therapy.

Defining milieu therapy.


Suicidal solution as a function of ego-closeness--ego-distance.


Time-limited psychotherapy for whom.

Time-limited psychotherapy for whom.


Design of catchment areas for community mental health services.


Antisocial and dyssocial. Entities of shibboleths?


Hallucinations and delusions as points on continua function. Rating scale evidence.


Family background and life situation in alcoholics. A comparative study of parental deprivation and other features in Australians.


Insulin tolerance test in depression.

Insulin tolerance test in depression.


Blood lactate in the development of anxiety symptoms. A critical examination of Pitts and McClure's hypothesis and experimental study.


Three-day hospitalization--a model for intensive intervention.


Distribution of albumin between plasma and thoracic duct lymph after haemorrhage.


Quantitative studies on the stimulation of mouse bone marrow colony growth in vitro by normal human urine.


The development of clones of antibody-forming cells in the spleens of irradiated mice. I. Detection of plaque-forming cell clonies, and their relationship to haemolytic foci.


The development of clones of antibody-forming cells in the spleens of irradiated mice. II. Some properties of plaque-forming cell colonies, and evidence for their clonal nature.


Esterase activities of beta-N-acetyl-D-glucosaminidase preparations.


The inhibition of succinate dehydrogenase by oxalacetate.


The ferrous ion as the cofactor of arginase in vivo. I. Properties of yeast arginase metallo-complexes of known composition and of native arginase.


The ferrous ion as the cofactor of arginase in vivo. II. Experiments on the replacement of ferrous ions in native yeast arginase by other cations in vivo.


Porphyrin biosynthesis. VI. Separation and purification of porphobilinogen deaminase and uroporphyrinogen isomerase from cow liver. Porphobilinogenase an allosteric enzyme.


Analytical method for the estimation of enzyme kinetic parameters.


4-Methylumbelliferyl phosphate as a substrate for lysosomal acid phosphatase.


Esters of phenols as substrates for pancreatic lipase.


Purification and properties of a fungal beta-glucosidase acting on alpha-tomatine.


pH-dependent deuterium isotope effects on L-amino-acid oxidase.


Optical anisotropy of synthetic polynucleotides. II. Calculation of pi-electron polarizability of uracil and adenine.


Identity of beta-glucosidase and beta-xylosidase activities in rat liver lysosomes.


Deformation behavior of erythrocyte ghost.


Molecular weight and dimensions of phycocyanin monomer and aggregates.


The biomedical communications network.

The biomedical communications network. The Biomedical Communications Network (BCN) is the embodiment of the plans of the National Library of Medicine to provide improved information, document, and education services to the health community. The BCN also will be the "core" public service network to ensure the most expeditious delivery of health information and education products to a selected public. As such, utilization of communications satellites as well as other more common forms of telecommunications are planned. The library component of the Network will provide decentralized library services to medical libraries, medical schools, hospitals, MEDLARS Centers, local medical centers and individual medical practitioners. These decentralized services will be provided through an information network with its hub at the Bethesda, Maryland site of the NLM. The NLM intends that the library services network be a controlled rather than a permissive system. This simply implies that participation and access to the services of the system will be determined by the NLM. Planning has already progressed to the point where services to be provided can be enumerated.


NERMLS: The first year.

NERMLS: The first year. The Countway Library, Boston, was the nation's first Regional Medical Library under the Regional Medical Library Program of the NLM. New England Regional Medical Library Service (NERMLS) began in October 1967 and is the outgrowth of traditional extramural services of the Harvard and Boston Medical Libraries (constituents of the Countway). During the first year over 27,000 requests were received of which 84 percent were filled. Some problems of document delivery (and their solution) are recounted. Other activities were: a limited amount of reference work; distribution of a Serials List; and planning for a region-wide medical library service. Proposals call for consultation and education, regional reference service, and improved document delivery service. Emphasis is placed on the role of the Community Hospital as a center for continuing education and the need to strengthen and assist hospital medical libraries. With the Postgraduate Medical Institute, Boston, NERMLS assisted in the compilation of a small physician-selected medical Core Collection which would serve as a minimum standard collection for community hospital libraries.