Appearance of an embryonic-like hemoglobin in the methotrexate-treated adult white Peking duck.


Tolerance to the induction of interferons by endotoxin and virus: role of a humoral factor.


Carbohydrate and protein metabolism in rats during chronic administration of glucagon and epinephrine.


Catecholamines in organs of immunosympathectomized mice.


The search for sense.

The search for sense.


Interferon production in Powassan virus infections of chickens.


Effect of hypophysectomy on feed intake in rats.


Reduction in life expectancy as a measure of radiation-induced genetic damage in mice.


Plasma levels of ovarian ascorbic acid depleting activity (luteinizing hormone?) in pregnant rabbits.


Effect of actinomycin-D on calcium homeostasis.


Enteric entry of microcrystals.

Enteric entry of microcrystals.


Effect of methionine on nicotinic acid and indoleacetic acid pathways of tryptophan metabolism in vivo.


Effect of hemodialysis on serum and parotid fluid phosphate levels.


Some effects of acute manganese excess in rats.


Positive direct Coombs' test induced by various azo dyes.


Differences in cytopathic effects of adenovirus in monkey kidney tissue culture.


Survival of intestinal allografts in the dog with and without immunosuppression.


Hyperbaric oxygenation in experimental cerebral ischemia.


Tissue pressures in fractures and sprains.


Sulfhydryl levels in regenerating rat liver in the presence of nitrogen mustard or protein-depletion diet.


Influence of oligodeoxyribonucleotides on the immune response of newborn AKR mice.


Lysine inhibition of cell protein and viral synthesis. Reversal by other amino acids.


Percutaneous cholangiography.

Percutaneous cholangiography.


Preservation of hearts by freezing.

Preservation of hearts by freezing.


Body temperature control instrument for hyperbaric use.


Hyperbaric oxygenation in aerobic infections.


Acute intestinal obstruction.

Acute intestinal obstruction.


Strangulation intestinal obstruction.

Strangulation intestinal obstruction.


Staged repair of pulmonic stenosis and hypoplastic right ventricle.


Immediate repair of traumatic rupture of thoracic aorta.


Intermittent claudication secondary to congenital absence of iliac arteries.


Evaluation of retrograde pelvic venography.


Late complications of peripheral arterial injuries.


Study of vascular lesions in diabetic, nondiabetic patients. Clinical, arteriographic, and surgical considerations.


Leiomyosarcoma of iliac and femoral veins.


Increased incidence of pulmonary metastases after celiotomy: counteraction by heparin.


Portal systemic shunting in experimental ammonia intoxication.


Barium appendicitis. Report of a case.

Barium appendicitis. Report of a case.


Fluid fluorocarbon as oxygenator in experimental extracorporeal circulation.


Optimum temperatures for postburn cooling.


Needle biopsy of thyroid.

Needle biopsy of thyroid.


Electrophoresis of chyle in bronchogenic carcinoma.


Distal antrectomy with vagectomy. Over five-year follow-up in 158 cases.


Chiari's disease. A clinicopathological study.


A new vascular holder for microsurgical procedures.


Growth hormone-releasing activity of hypothalamic extracts at different ages.


Relative effectiveness of estradiol and coumestrol on the reversal of castration changes in the anterior pituitary of mice.


Inhibition of the release of the ovulating hormone in immature rats with hypothalamic lesions.


Testosterone synthesis by the fetal rabbit gonad.


Thyroid hormone-catecholamine interrelationships.


Conjugation of thyroid hormones and analogs by the Gunn rat.


Effect of reserpine on prolactin-inhibiting activity of rat hypothalamus.


Effects of LH and ovarian hormones on corpora lutea of pseudopregnant and pregnant rabbits.


Steroid concentration and tissue integrity as factors determining the physiological significance of effects of adrenal steroids in vitro.


Effect of dinitrophenol on pituitary-thyroid activity in the rat.


Homeostasis of plasma calcium: effects of actinomycin D, parathyroidectomy and thyrocalcitonin.


Substances present at the hypothalamic level and growth hormone releasing activity.


Comparison of the recovery of inorganic iodide by paper electrophoresis or chromatography.


Variations of cardiac glycogen and plasma inorganic phosphorus with age and sex in the white rat.


Effect of NADP-glycohydrolase on glucose-6-phosphate dehydrogenase.


Human blood pressure and the ABO blood group system: an apparent association.


Adolescent sterility in an Indian population.


Fetal wastage in eleven Punjab villages.


Weights, heights and chest circumferences of English East Midland coal miners in 1952-62.


The patterns of hand clasping in different ethnic groups.


Nutritional beliefs and practices.

Nutritional beliefs and practices.


Nitrogen balance studies on women in India.


Influence of breakfast on total day's food intake.


Dietary survey of adolescents in the Virgin Islands.


Food habits and nutrient intakes of preschool children.


Medical dietetics. I. An experiment in dietetic education in a college of medicine.


Medical dietetics. II. The development of evaluative techniques.


Performance evaluation form for food service employees.


Report of the fifteenth Thomas Baker Memorial fellow to the College of Radiologists of Australasia.


Surgical management of vasorenal hypertension.


A method of venous cannulation in direct vision mitral valve surgery.


Radiographic features of the battered child syndrome.


Double-dose urography--renal function test.


Pulmonary calcification following chickenpox in childhood.


Severe renal dysfunction following polybrene medication.


Diverticulosis and ileo-caecal valve competence.


Acute obstruction of the external iliac artery due to circumferential intimal fracture.


Application of the electric pace maker of the heart under hypothermia. Experimental study on the maintenance of the cardiac action under deep hypothermia (16 degree C. below).


Kite uterus: two case reports.

Kite uterus: two case reports.


Nodular sclerosing Hodgkin's disease.

Nodular sclerosing Hodgkin's disease.


Thyroid uptake tests in patients with malignant lymphomas.


A report on the radiotherapy of multiple hereditary telangiectasia.


Ionizing radiations and chromosomes.

Ionizing radiations and chromosomes.


Radioactive assay of bulky samples.

Radioactive assay of bulky samples.


Mitral stenosis and mitral regurgitation. Correlation of operative and intraoperative diagnostic findings.


The use of radiocolloids in ovarian carcinoma in the prevention of post-surgical recurrence.


Complete heart block following open heart surgery.


A simplified unit for full-size chest examination.


A light-beam diaphragm modification for "miniature" chest radiography.


Automatic collimation in fluoroscopy with image intensifier.


Clinical use of hemodilution in extracorporeal circulation.


The image intensifier compared with conventional fluoroscopy for routine gastro-intestinal investigation.


Surgical treatment of post-thrombotic leg ulcers.


Comprehensive mental health care.

Comprehensive mental health care.


Present-day diagnosis and treatment of gout.


Care of the feet of the rheumatoid patient.


Neonatal spontaneous gastric perforation, with  survival.


University of Iowa College of Medicine. Clinical pathologic conference.


The social characteristics of 100 alcoholic patients.


The neurologic complications of diabetes mellitus. A symposium.


Vestibular caloric testing and cupulometry.


The atypical depressive illnesses.

The atypical depressive illnesses.


Excretion pattern of labelled spermatozoa and the timing of spermatozoa formation and epididymal transit in rabbits injected with thymidine-3-H.


Blastocyst survival and nidation in rats treated with oestrogen antagonists.


Glutamic-oxaloacetic transaminase in human semen and reproductive organs.


Experimental ectopic implantation of eggs and early embryos in guinea-pigs.


Successful transfer of a fertilized bovine egg by non-surgical techniques.


A comparison of 35-S methionine incorporation by the blastocysts of normal and delayed implanting mice.


Sympathetic nerves and reproductive organs in the male rabbit.


Studies on the mechanism of nidation. 13. The relationship between chemical structure and biodynamic activity of certain ergot alkaloids.


Studies on the development of mouse embryos in vitro. IV. Interaction of energy sources.


Passage of spermatozoa labelled with thymidine-3-H through the ductus epididymidis of the rabbit.


Difference between two inbred strains of mice in ovulatory response to repeated administration of gonadotrophins.


Transaminases in the epididymal fluid of the ram.


Strain differences in susceptibility of mice and rats to cadmium-induced testicular damage.


Effect of cadmium chloride on the pregnant albino mouse.


In-vitro fertilization of mouse ova within the explanted fallopian tube.


Pseudotumor cerebri: a historical and clinical review.


Pediatric anesthesia.

Pediatric anesthesia.


Nasopharyngeal teratoma.

Nasopharyngeal teratoma.


Leiomyoma of the small intestine: clinicopathologic considerations.


The relationship between perforated peptic ulcer and aspirin ingestion.


Polycythaemia rubra vera.

Polycythaemia rubra vera.


Inheritance of the Vel blood group in three families.


Acute non-calculous cholecystitis; a case report.


The optimum position for childbirth.

The optimum position for childbirth. Postures adopted in childbirth for bearing down are varied today.  Bearing down causes an increase in intra-abdominal pressure which helps the expulsive phase of the uterus during labor, and this is brought about predominantly by the muscles of the anterior abdominal wall.  These muscles exert a compressive force when the thorax and pelvix are fixed.  In order for this to be done efficiently, the postural requisite is 2-fold.  The parturient must have all portions of her spine semiflexed--her shoulders should be raised about 6-10 inches off the bed and her chin should be flexed to come within about 2 inches of her chest.  2nd, while her thighs are flexed and parted, her feet must be firmly placed on the delivery table.  The assisting personnel must correctly support the parturient to avoid unnecessary exertion and tiring.  This position allows the parturient to push to the best of her ability and simultaneously to feel reasonably comfortable.  It also permits the attendant adequate access both to the perineum and to the abdomen and the fetal heart sounds.  The choice of this position as the optimum position is based on anatomical and physiological facts.  The fallacies underlying some aspects of present-day posturing are identified.


Management of polycythaemia vera.

Management of polycythaemia vera.


Hospital diets--why?

Hospital diets--why?


Unity of the profession--we are all doctors.


Experimental allergic uveitis: homologous retina as uveitogenic antigen.


Aldehyde mutase.

Aldehyde mutase.


Some structural features of borrelidin, an anti-viral antibiotic.


A highly purified preparation of juvenile hormone from the silk moth Hyalophora cecropia L.


Globulin on cells of cancer patients.

Globulin on cells of cancer patients.


Accumulation of lysolecithin in rat brain on incubation in vitro.


Cytocidal activity of plant auxin analogues against the Ehrlich ascites carcinoma.


Effect of adenosine-5-monophosphoric acid or inosine on porphyria caused by griseofulvin in rats.


Formation of histamine in the cotton plant.


Banana tannin and its reaction with polyethylene glycols.


Effect of aldosterone and corticosterone on beta-galactosidase and invertase activity in the small intestine of rats.


Exceptional carotenoid metabolism in the Andean flamingo.


Structure-phytoactivity relationships in the penicillins.


Reactivity of disulfide bonds in strained keratin.


Heat transfer in the laminar flow of human blood through tube and annulus.


Acetylcholinesterase in the sarcoplasmic reticulum of skeletal muscle.


Retardation of the ageing process in collagen fibres from the tail tendon of the old hypophysectomized rat.


Effect of d-tubocurarine on uptake of labeled carbaminoyl choline in brain slices of the rat.


A new intact mammalian muscle preparation suitable for in vitro investigations.


Plecotus austriacus in Dorset.

Plecotus austriacus in Dorset.


Choline acetylase inhibitors as potential antihallucinogens.


Effect of tranylcypromine on the blood pressure response of tyramine.


"Clicking" in the egg-young of nidifugous birds.


Effect of ringing on potassium uptake by Ricinus communis plants.


Relation of ringing to gibberellin-like activity in berries of Vitis vinifera L.


Response of oxidation and phosphorylation in citrus mitochondria to arsenate.


Inactivation of brucellaphages by chemical fractions of Brucella.


Effects of high partial pressures of oxygen on fungi and bacteria.


Selection and polygenes.

Selection and polygenes.


Further evidence of heterozygosity in parthenogenetic turkeys.


Tobacco mosaic virus inclusion bodies in tobacco tissue cultures.


A patient with cerebral hypoxia nursed in an intensive care unit.


New frontiers in social medicine.

New frontiers in social medicine.


The basic management of acute poisoning.


The SEN in psychiatric hospitals.

The SEN in psychiatric hospitals.


A waitress service at Burton-on-Trent.

A waitress service at Burton-on-Trent.


Vulnerable groups. 4. The unmarried mother.


Pyrogens.

Pyrogens.


Preparing the educationally subnormal for citizenship.


Groundless fears.

Groundless fears.


Hope for millions.

Hope for millions.


The hospital centre: nurse planners meet matrons of new hospitals.


The electrical constants of single muscle fibres of the crayfish (Astacus fluviatilis).


The distribution and content of myoglobin in the heart of the rat during postnatal development.


The relationship between the capillaries and protein nitrogen in the myocardium of the rat during postnatal development.


The coronary terminal vascular bed in the heart of the hare (Lepus europeus) and the rabbit (Oryctolagus domesticus).


Partial block of castration hypertrophy of the adenohypophysis in male rats by thyreodin.


Thermostability of rat erythrocytes irradiated in vitro with large doses of ionizing radiation.


Effect of large doses of ionizing radiation on the phagocytic activity of leucocytes in preserved blood.


Concerning the relationship between serum and soluble liver proteins in the rat.


On the question of anaemic liver injury in rats and mice.


Effect of protracted glucose infusion on the development of early biochemical changes and initiation of regeneration in rat liver after partial hepatectomy.


D.C. potential and high frequency impedance of the cerebral hemispheres in guinea-pig fetuses in the perinatal period.


Concerning the metabolic substrate of central nervous activity durging early postnatal development of the rat. The  effect of lactate on oxygen consumption in nervous tissue.


The effect of mechanical factors on the origin of respiratory waves in the plethysmogram of the hand.


Device for automatic control and programming of experiments with "situational" conditioned reflexes in dogs.


The rhabdom of the lobster eye.

The rhabdom of the lobster eye.


Movement of palisade in locust retinula cells when illuminated.


The ultrastructure of the  tegument of Moniliformis dubius (Acanthocephala).


The organization and replacement of the epidermis in acoelous turbellarians.


Biology of Anopheles quadrimaculatus under field conditions in central Florida.


Sodium: potassium ratios in insect cell culture and the growth of cockroach cells (Blattariae: Blattidae).


Some effects of gamma radiation on the potato tuberworm, Gnorimoschema operculella (Lepidoptera: Gelechiidae).


Some gamma radiation effects on host-parasitoid relationships.


Phyletic relationships within the Blattidae.


Dispersal studies of Trichogramma semifumatum (Hymenoptera: Trichogrammatidae) tagged with radioactive phosphorus.


A serviceable irradiator-shield device.

A serviceable irradiator-shield device.


Defense mechanisms of arthropods. XVI. Para-benzoquinones in the secretion of spirostreptoid millipedes.


Training in surgical pathology.

Training in surgical pathology.


Intestinal renewal and immunosympathectomy.


Pathological and serum-enzyme changes after epinephrine in oil and adrenergic blocking agent.


Renal and extra-renal lesions induced by heterologous serum.


Myocardial infarction and pulmonary embolism.


Study of the human placenta with the electron microscope. Functional implications of a canal system in the trophoblast.


Dietary-induced atrial thrombosis in mice.


A malignant true teratoma of liver in childhood.


Erythrokinetic effect of parental spleen cells in hybrid mice.


Mesenchymal hamartoma of liver.

Mesenchymal hamartoma of liver.


Lesions of connective tissue with streptococcal cell walls.


Thrombosis of the medullary adrenal vein.


Inhibition of greening of etiolated leaves by antinomycin D.


3-O-Caffeoylshikimic acid (dactylifric acid) and its isomers, a new class of enzymic browning substrates.


A strand disproportionation reaction in a helical polynucleotide system.


Nuclear ribosomes, an early factor in tissue reparation.


The stabilizing effect of ADP and the binding of ADP by the threonine dehydrase of Clostridium tetanomorphum.


Unstable rII mutants of bacteriophage T4.


Labeling of RNA of isolated nucleoli with UTP-14C.


X-ray spectroscopy in biology and medicine. VI. Use of an ultra-soft x-ray source for the nondestructive detection of microgram amounts of sodium and magnesium.


Inhibition of kidney and intestinal mutarotase by actively absorbed sugars.


The biosynthesis of coumarin in Melilotus alba.


Biological activity of all-trans retinol 2, all-trans retinene 2 and the 13-cis and 9-cis isomers of retinol 2.


Synergism of d- and 1-alpha-tocopherol during absorption.


Studies on the absorption, distribution and metabolism of 1-alpha-tocopherol in the rat.


Glutamate auxotrophs in Saccharomyces 1. I. The biochemical lesion in the glt-1 mutants-2.


Selective modification of cytidine residue in ribonucleic acid by semicarbazide.


The polyunsaturated 20-carbon and 22-carbon fatty acids of Euglena.


Biotin-binding by parenterally-administered streptavidin or avidin.


Limited action of actinomycin D on protein synthesis in adrenalectomized rats.


Infrared study of helix strandedness in the poly A-poly U system.


Inhibition by digitonin of bovine heart muscle DPNH-cytochrome c reductase and its specific reversal by the tocopherols.


4-Methoxyphenylethylamine and 3,4-dimethoxyphenylethylamine in human urine.


Transport studies with peptides containing unnatural amino acids.


The mode of action of lincomycin.

The mode of action of lincomycin.


Enzymatic formation of homocitric acid, an intermediate in lysine biosynthesis.


Enzymatic conversion of homoisocitric acid into alpha-ketoadipic acid.


Chromatography of tri- and tetranucleotides from pancreatic ribonuclease digests of ribonucleic acid.


The enzymatic synthesis of gangliosides. I. The incorporation of labeled N-acetylneuraminic acid into monosialoganglioside.


Enzymatic dehalogenation of 2,2-dichloropropionate.


Necessity of the disulfide bond of vasopressin for antidiuretic activity.


A familial study of a human enzyme defect, argininosuccinic aciduria.


Chymotrypsin-substrate complexes. Hydrogen ion equilibria in chymotrypsin and diisopropylphosphoryl-chymotrypsin.


Inhibition of host cell reactivation in phage T1 by caffeine.


Conformational changes accompanying the formation of chymotrypsin-substrate complexes. Evidence for the involvement of an N-terminal alpha-amino group in the activity and the conformation of the enzyme.


Putrescine and related amines as growth factors for a mammalian cell line.


Biosynthesis of phytoglycogen from adenosine diphosphate D-glucose in sweet corn.


Adenosine diphosphate mannose, adenosine diphosphate galactose and adenosine diphosphate acetylglucosamine from corn grains.


Structural changes in isolated rat kidney mitochondria treated with phlorizin and ATP.


Incorporation of D-serine into the cell wall mucopeptide of Micrococcus lysodeikticus.


Enzymatic polymerization of UDP-acetylmuramyl.L-ala.D-glu.L-lys.D-ala.D-ala and UDP-acetylglucosamine by a particulate enzyme from Staphylococcus aureus and its inhibition by antibiotics.


Conversion of D-tryptophan to L-tryptophan by cell extracts of a Flavobacterium species.


DNA-dependent RNA synthesis in chloroplast preparations.


Hydrolysis of phenylthiohydantoins of amino acids.


Synthesis of 3:3' diiodothyronine by beef thyroid microsomes.


Metabolsm of chlorpromazine. V. Confirmation of position 7 as the major site of hydroxylation.


Peptide bound flavins and succinic dehydrogenase activity in the brain.


Occurrence of a docosatrienoic acid in the cholesterol esters of adrenals of rats on essential fatty acid deficient diets.


Biosynthesis of mutard oil glucosides. 3. Formation of glucotropaeolin from L-phenylalanine-C14-N15.


Ion accumulation in heart mitochondria supported by the oxidation of reduced cytochrome c.


Glycine synthesis and isocitrate lyase in the nematode, Caenorhabditis briggsae.


Isolation and inhibitory effects of KB cell cultures of 3'-deoxyandenosine from Aspergillus nidulans (Eidam) Wint.


Identification of cordycepin, a metabolite of Cordyceps militaris, as 3'-deoxyadenosine.


The effect of chemical modification of DNA on its priming activity with RNA polymerase.


Chemical reactivity of models related to a proposed CO2--biotin-enzyme complex. 3.


Nonenzymic decarboxylation of the aminobenzoates.


Product activation of yeast threonine dehydratase by ammonia.


Glutamic acid synthesis from acetate units and bicarbonate in extracts of photosynthetic bacteria.


Formation of galactolipids by chloroplasts.


Specificity of flavin adenine dinucleotide pyrophosphorylase for flavin phosphates and nucleoside triphosphates.


Isolation and characterization of a glycopeptide from sheep thyroglobulin.


Inhibition of DNA polymerase by histones.


Studies on pyruvate carboxylase activity in alloxan diabetic and normal animals.


A possible intermediate in the reduction of 3'-phosphoryl-5'-adenosinephosphosulfate to sulfite.


Conversion of L-tyrosine to 3,4-dihydroxyphenylalanine by cell-free preparations of brain and sympathetically innervated tissues.


The nature of the peptides released from canine fibrinogen.


Factors affecting the activity of muscle glycogen synthetase.


Effect of ADP on the inhibition of oxidative phosphorylation by potassium atractylate.


Observations on the regulation of DNA biosynthesis.


Amino acid composition of Bacillus licheniformis.


The alpha-chymotrypsin-catalyzed hydrolysis and hydroxylaminolysis of acetyltyrosine p-nitroanilide.


A reconstituted system of oxidative phosphorylation.


Metabolic conversion of thymine-2-C-14 and its incorporation into nuclear RNA of endosperm nuclei of Cocos nucifera Linn.


"Kinasine"--a glycolysis stimulating protein of heart mitochondria.


On the activation and catalytic mechanism of microbial tryptophan pyrrolase.


The hazards of painting and varnishing 1965.


Mesothelioma of pleura and peritoneum following exposure to asbestos in the London area.


A continuously recording atmospheric carbon monoxide monitoring system with fully automatic alarms in a blast furnace area.


Bone marrow changes in silicosis.

Bone marrow changes in silicosis.


Silicosis from quarrying and working of granite.


Byssinosis in cotton ginneries in Greece.


Ventilatory capacity changes on exposure to cotton dust and their relevance to byssinosis in Australia.


A survey of dust concentrations in flax mills in Northern Ireland.


Studies in lead poisoning. Comparison between different laboratory tests.


Further observations on the mechanical fragility of the red cell in lead poisoning.


Value of ED50 testing in assessing hazards of acute poisoning by carbamates and organophosphates.


Iodine-azide test on urine of persons exposed to carbon disulphide.


Aspartate carbamoyltranspherase in higher plants.


Inhibition of RNA and protein synthesis in cell culture by actinomycin D.


Variations in the primary production of plankton and periphyton in the littoral zone of lakes.


On certain species of the genus Henosepilachna Li (Coleoptera, Coccinellidae) from New Ireland.


Naupliicola necans g.n., sp.n. and Naupliicola truncans sp.n. (Euglenoidina)--parasites of copepod larval forms.


The character of the plasmolysis in the cortical layer of apple shoots.


Conditioning of centrally induced rumination in goats.


Acute renal hypertension induced by a lipid fraction from tissues.


Variations of plasma and kidney renin contents during experimental acute renal hypertension induced by extracts from different tissues.


On the intracellular distribution of glycogen and phosphatases in leucocyte homogenates.


Application activity and MCAT data of applicants to the class of 1964-65.


The AAMC study of medical student attrition: overview and major findings.


The AAMC study of medical student attrition: school characteristics and dropout rate.


Instruction in scientific communications.


Teaching comprehensive medical care: an exploratory study of some short-term effects.


The development of medical education in Paraguay through an AID-university contract.


A flexible teaching laboratory in biochemistry.


Hemorrhagic pancreatitis following a kick in the abdomen. Report of a case.


Examinations as devices for evaluation.

Examinations as devices for evaluation.


A critical evaluation of research and teaching in anatomy.


Driving under the influence of alcohol. 7. The legislation in operation in Tennessee, Georgia, New York, Canada, Scotland.


Do we need anatomists or anatomy departments?


Science in surgery.

Science in surgery.


Reinforcement experiment in laboratory pharmacology by film: a model for cinematic self-instruction in medical education.


Integration of training programs in Tucson.


The present status of the AMA accreditation of continuing medical education.


Mycobacterium minetti (Penso et al., 1951).


On the production of alpha-ketoglutaric acid by non-proliferating cells of Pseudomonas reptilivora Caldwell et Ryerson from cultures of different age.


The pathogenesis of bovine lymphomatosis.


Splenocytin, a protective and curative product of murine spleen cells.


Intermittent combination therapy with INH and thiambutosine (CIBA-1906) in tuberculous mice.


The physician and physical education of the school child.


Athletic injuries in children.

Athletic injuries in children.


The school physician as an active member of the school staff.


School health and the private physician.


The school plant and healthful school living.


National aspects of school health.

National aspects of school health.


Health appraisal of school-age children.


The school child and defective vision.

The school child and defective vision.


Hearing loss in children.

Hearing loss in children.


Diabetes in school children.

Diabetes in school children.


Accidents and school children.

Accidents and school children.


Communicable disease control in schools.


Learning problems and school phobia.

Learning problems and school phobia.


'Hunt the signal'.

'Hunt the signal'.


The early orthodontic treatment of alveolar clefts.


The place of measurement in the management of acutely ill patients. Measurement in the intensive care of heart disease.


The place of measurement in the management of acutely ill patients. Monitoring in patients with respiratory failure.


The place of measurement in the management of acutely ill patients.


The measurement of blood pressure. Electromanometry.


Coarse pyelonephritic scarring or 'atrophic pyelonephritis'.


A new treatment for rectal prolapse.

A new treatment for rectal prolapse.


Prognosis of patients with an ileostomy.


Medical radio telemetry.

Medical radio telemetry.


Some factors affecting hair growth in man.


Metabolic aspects of anorexia nervosa.

Metabolic aspects of anorexia nervosa.


Capacity and incapacity for work: some recent history.


Sickness absence and return to work.

Sickness absence and return to work.


Work and illness.

Work and illness.


Renal arteriography in hydronephrosis. Its value in diagnosis and management.


Stenosis of the celiac artery.

Stenosis of the celiac artery.


Collateral circulation in cerebrovascular disease in childhood via rete mirabile and perforating branches of anterior choroidal and posterior cerebral arteries.


The subvalvar aortic jet.

The subvalvar aortic jet.


Experimental coronary arteriography. 3. Injuries associated with selective coronary arteriography.


Percutaneous transaxillary selective coronary angiography.


Technic of transseptal catheterization of the left atrium, pulmonary veins, and left ventricle in the dog.


Transverse myelitis following selective bronchial arteriography.


Clinical evaluation of side-effects of radiopaque contrast media administered via intravenous and intra-arterial routes in the same patient. A preliminary report.


The roentgen appearance of schistosomiasis Mansoni involving the colon.


Water-soluble contrast media in the roentgenographic diagnosis of hypertrophic pyloric stenosis in infants.


A roentgen sign in strangulating obstructions of the small intestine.


Peroral cannulation of the ampulla of Vater for direct cholangiography and pancreatography. Preliminary report of a new method.


The thyroid scintigram. II. The cold nodule.


Early invasive carcinoma of the cervix. A problem of definition and treatment.


A new method for obtaining multi-field and rotational dose distributions in cobalt-60 teletherapy.


Management of Hodgkin's disease coexistent with pregnancy.


A new versatile microdensitometric system for quantitative radiographic analysis.


Possible errors in the ferrous sulfate dosimeter.


New instrumentation for cerebral microangiography.


Capnohepatography: intravenous retrograde gas angiography of liver veins with carbon dioxide.


The current plight of the academic department of radiology.


Electroencephalographic studies in experimental pulmonary oedema.


Data to the pathomechanism of the shock kidney. II. Effect of mercuric chloride on tubular function.


Data to the pathomechanism of the shock kidney. 3. Effect of dehydration shock on renal function.


Studies on the pathogenesis of pulmonary alloxan oedema.


Correlation between isolated cerebral hypercapnia and pulmonary oedema.


The problem of the arterio-venous anastomoses of the kidney. IV. Extraction of PAH and O-2 and corrosion studies in the denervated kidney in traumatic shock and following human serum albumin administration.


Effect of capsaicin on experimental ulcer in the rat.


Oviposition by Anopheles melas and its effect on egg survival during the dry season in the Gambia, West Africa.


Electron microscopy of the contact chemoreceptors of the stable fly, Stomoxys calcitrans (Diptera: Muscidae).


Late cutaneous syphilis.

Late cutaneous syphilis.


Metabolism of polycyclic compounds. 23. The metabolism of pyrene in rats and rabbits.


Increased platelet adhesiveness in recurrent venous thrombosis and pulmonary embolism.


Stuttering. The effect of treatment with D-amphetamine and a tranquilizing agent, trifluoperazine. A preliminary report on an uncontrolled study. In an institution for the mentally retarded, an uncontrolled study was made on the effects of d-amphetamine, d-amphetamine followed by trifluoperazine, and of combined d-amphetamine and trifluoperazine on stuttering. Of 28 patients to whom d-amphetamine was given, 14 showed improvement after one month's treatment. Eight more showed improvement when trifluoperazine was given for one month to those who did not improve on d-amphetamine. In many cases, improvement was sustained at least six months after treatment was discontinued. Treatment with d-amphetamine was apparently more effective in patients with functional than with organic retardation.


A renewed plea for the isolation of shingles. Report of a case.


Prevention of adrenal cortical hypertrophy in diabetic rats by the use of ascorbic acid.


Contribution to the study of the skin innervation in certain laboratory animals. II. White rat and white mouse.


Angiocardiography.

Angiocardiography.


Gastric suction biopsy in a case of amyloidosis: a case report with discussion of gastroenterological amyloidosis and methods of diagnosis.


Postoperative esophageal obstruction.

Postoperative esophageal obstruction.


Mucosal diaphragm of the gastric antrum.


Gastroparesis diabeticorum.

Gastroparesis diabeticorum.


Tessalon as a local anesthetic in peroral endoscopy.


Patient response to gastroscopy.

Patient response to gastroscopy.


Color photography of the stomach.

Color photography of the stomach.


Pyloroduodenal ulcer: endoscopic aspects.


Circus reexcitation as a cause of repetitive activity in crayfish lateral giant axons.


Possible carriers in erythrocytes.

Possible carriers in erythrocytes.


Systemic effects of epinephrine in the frog.


Properties of contractile protein from bovine carotid artery.


Renal transport of glucose by the aglomerular fish Lophius americanus.


Modification of cardiac and respiratory rhythms in crayfish following carbohydrate chemoreception.


The effect of potassium concentration on Ca45 uptake in frog sartorius muscle.


Oxygen consumption, thermal conductance, and torpor in the California pocket mouse Perognathus californicus.


Red cell and plasma sodium and potassium changes in the San Diego pocket mouse during hibernation.


The relation between the torpor cycle and heat exchange in the California pocket mouse Perognathus californicus.


Photodynamic and fluorochromic properties of the antibiotic actinomycin D.


The effect of pyridoxal on potassium fluxes in the Ehrlich mouse ascites tumor cell.


The action of bile salts on fluid and glucose movement by rat and hamster jejunum, in vitro.


The effect of bile salts on tissue ATP levels of everted sacs of rat and hamster ileum.


Effects of physical location of visual stimuli on intentional response time.


Recovery from the effects of isometric muscle contractions.


The effect of light and sound variables on reaction time.


Viscero-cardiac reflexes following distension of stomach.


Serum sodium and potassium levels in normal Indian adults (237 subjects).


Vitamin A deficiency and capillary resistance in rats.


Somatic (muscle) and somato-vascular response in hypothermia and its modifications by anaesthetics.


Study of some of the mechanisms connected with resistance to diazinon and diazoxon in a diazinon-resistant strain of houseflies.


Arteriovenous anomalies of the brain. Fate of patients not having definitive surgery.


Incidence of intracranial vascular lesions in patients with subarachnoid hemorrhage investigated by four-vessel angiography.


Visual loss associated with fusiform enlargement of the intracranial portion of the internal carotid artery.


Further studies on the effectiveness of agents used to lower intracranial pressure.


The effect of local cerebral hypothermia on the electrocorticogram and on experimental epileptic activity.


The training of a neurosurgeon. A review of an international problem.


Acute bilateral extradural hematomas. A case report.


Traumatic aneurysm of the intracranial extradural portion of the internal carotid artery. Report of a case.


Congenital arteriovenous aneurysm in the neck. A case report.


Spinal cord metastasis from bronchogenic carcinoma. A case report.


Intraneural cyst of the peroneal and ulnar nerves. Report of two cases.


Phycomycosis (mucormycosis) of the central nervous system. Report of a case.


Production of clones of lymphoid cell populations.


Non-occurrence of lotusin in Lotus arabicus L.


The effects of early object relationships on sexual development. Autistic and symbiotic modes of adaptation.


A simple and accurate method for the routine determination of the serum iron, copper and iron-binding capacity.


Radiolysis of estrone and estradiol.

Radiolysis of estrone and estradiol. Gamma irradiation of estrone and estradiol in 1 Naqueous sodium hydroxide results in the formation of 2-hydroxyestrone and 2-hydroxyestradiol, respectively. Estrolactone (16a-oxa-D-homoestrone) was not encountered.


Computer-aided instruction.

Computer-aided instruction.


Chemical-biochemical signal and noise.

Chemical-biochemical signal and noise.


Reversible, light-screening pigment of elasmobranch eyes: chemical identity with melanin. There lies directly beneath the tapetum lucidum, in the eyes of many elasmobranch fishes, a layer of darkly pigmented choroid cells which, in bright light, extend individual strands that aggregate to form a dark, compound curtain which shields the reflecting tapetal cells. This process is reversed in dim light or in darkness; the tapetum is exposed and visual sensitivity presumably Increased. The black choroid pigment has been isolated, analyzed, and shown to possess the properties of melanin.


Ribosomes: analysis by cesium sulfate gradient centrifugation. Ribosomes from the cytoplasm of a mammalian tissue, HeLa cells, were partially purified and then concentrated into a zone by prolonged centrifugation in Cs(2)SO(4) solution (density, 1.43 grams per milliliter). Ribosomal preparations treated with bentonite prior to density-gradient centrifugation showed single peaks after centrifugation. Material recovered from the peaks represented aggregates of the original 74S particle.


Regulation of cockroach fat-body metabolism by the corpus cardiacum in vitro. Incubation in vitro of young, adult, male Leucophaea maderae fat body with extracts of corpora cardiaca or intact corpora cardiaca results in stimulation of oxygen consumption but reduction in carbon dioxide evolved from carbohydrate. The carbohydrate is preferentially used for trehalose synthesis, and the endogenous metabolism of the fat body appears to be supported by increased lipid utilization. A hormone from the corpus cardiacum is most likely responsible for these effects and may act at two points, at least, in the glycolytic pathway.


Glycerol metabolism in the human liver: inhibition by ethanol. Glycerol is metabolized predominantly in the liver, the first step presumably being phosphorylation to alpha-glycerophosphate. When ethanol is present in the blood the rate of glycerol uptake by the splanchnic organs is reduced to about one-third of the control value. At the same time glycerophosphate accumulates in the liver. Hepatic blood flow and oxygen consumption are not influenced by the combined infusion of glycerol and ethanol. The phenomenon may be connected with the increased concentration of the reduced form of diphosphopyridine nucleotide present in the liver during ethanol metabolism.


Sperm capacitation by uterine fluid or beta-amylase in vitro. Rabbit sperm developed the capacity to fertilize ova when incubated in utero or in vitro in fluids from estrous uteri. Incubation of sperm with beta-amylase in phosphate-buffered Locke's solution also resulted in capacitation. The data suggest that sperm capacitation involves enzymatic alteration of carbo-hydrate-containing seminal macromolecules which coat sperm and inhibit fertilization.


Lithocholic acid in human-blood serum.

Lithocholic acid in human-blood serum. Lithocholic acid was present in the serum of three patients with, jaundice and, in smaller amounts, in two healthy adults. This bile acid occurs naturally in human feces but induces cirrhosis of the liver when fed to a wide variety of experimental animals. The finding of lithocholic acid in blood is of interest because of its possible role in injuring human liver.


Collagenase: effect on the morphogenesis of embryonic salivary epithelium in vitro. Salivary epithelium in culture, under conditions which promote morphogenetic branching, grows as a simple disc in the presence of collagenase, or is "depatterned" midway in the morphogenetic course by a short exposure to a collagenase.


Protein synthesis in rat liver: influence of amino acids in diet on microsomes and polysomes. Rats were killed 1 hour after having been fed by stomach tube with amino acid mixtures that were either nutritionally complete or lacked tryptophan. Microsomes isolated from the livers of animals fed the incomplete mixture showed a reduced capacity to incorporate (14)C-leucine in vitro, and polysomes prepared from the same livers showed an increased proportion of monosomes and disomes. Prior treatment with actinomycin D did not prevent these differences in response to the two amino acid mixtures, an indication that synthesis of messenger RNA may not be involved in the cell mechanism which recognizes differences in amino acid pattern.


Spectrophotometer: new instrument for ultrarapid cell analysis. A new device has been developed for measuring and displaying multiple spectrophotometric properties of biological cells at rates exceeding 500 cells per second. Preliminary observations of human cells from different sites in the body were made at wavelengths of 2537 and 4100 angstroms to estimate cellular nucleic acid per unit volume of individual cells of large populations of cells. Display patterns were obtained which were consistent, and characteristically different for certain of the cell populations studied.


Odorous secretion of normal and mutant  Tribolium confusum. An autosomal recessive mutant characterized by "melanotic stink glands" has been found in the tene-brionid flour beetle, Tribolium confusum. The contents of the reservoirs of both pairs of odoriferous glands become modified in two ways as the beetles age. (i) The quinones (2-ethyl- and 2-methyl-1,4-benzoquinone) present in the secretion are reduced to 1/20 of that normally found in the wild type. (ii) The contents may be modified into a high-molecular-weight polymeric substance, which becomes visible through the exoskeleton and, upon dissection, appears as a black solid lump. The medium in densely populated cultures of the mutant becomes moldy while that containing normal beetles remains particulate. This difference suggests that one of the functions of the secretions of the odoriferous glands is to prevent the growth of fungi or bacteria in the nutrient flour.


Differential-approach tendencies produced by injection of RNA from trained rats. Two groups of rats were trained in a Skinner box to approach the food cup when a discriminative stimulus (click or blinking light) was presented. Ribonucleic acid was extracted from the brains of these two groups of rats and injected into two groups of untrained rats. The untrained two groups then manifested a significant tendency (as compared with one another) to react differently to the two stimuli. On the average, the response appeared to be specific to the stimulus employed during training.


Soluble proteins of a melanoma and normal skin from the swordtail, platyfish, and their hybrids. Acrylamide gel electrophoresis has been used to make comparisons of the distribution of soluble protein and the activity of esterase in skin and melanoma extracts of the swordtail, the platyfish, and their hybrids. There is a striking difference between the extracts of normal skin and tumor tissue derived from the same cytological elements. Several prominent protein bands are found only in the tumor tissue. Their origin and function are unknown.


Nicotine: effect on the sleep cycle of the cat. Small doses of nicotine (0.005 to 0.01 milligram per kilogram of body weight) given intravenously to sleeping cats with indwelling brain electrodes produce (i) initial electroen-cephalographic activation which was accompanied by behavioral arousal; (ii) a few minutes later, slow-wave sleep; and (iii) within 15 to 30 minutes, fast-wave sleep. Although peripheral afferent stimulation, release of epinephrine, and arginine vasopressin contribute to the initial arousal effects, the primary action of nicotine appears to be on the central nervous system.


Cambridge explosion: study of accelerator accident continues.


Permeability of a nuclear membrane: changes during normal development and changes induced by growth hormone. The ion permeability of the nuclear membrane envelope of salivary gland cells (of the midge Chironomus thummi) undergoes changes during development. Following the early fourth instar stage, permeability falls to about one-fifth of its base value over a period of 3 to 5 days of development of the animal, and then rises again over the next 2 to 4 days. The falling phase of the change can be reproduced within 1 hour by injections of the growth hormone ecdyson.


Studies on bacterial contamination of spices used in meat products.


Effect of actinomycin D on the development of the compensatory hyperfunction of the myocardium, kidney and liver.


Experimental investigations on neurosecretion in mudfish (Misgurnus fossilis L.).


Glomerulometrics. II. New data concerning the growth of glomeruli in the albino rat.


Glomerulometrics. 3. Data referring to the growth of the glomeruli in man.


Studies on excretion in the common Indian leech, Hirudinaria granulosa (Savigny).


Electron microscopy of the median eminence of the rat.


Lamellar bodies in Purkinje cells of the guinea pig.


The Purkinje cell baskets: ultrastructure of an inhibitory synapse.


The epidemiology of rheumatoid arthritis and human ecology.


Indomethacin in ankylosing spondylitis.

Indomethacin in ankylosing spondylitis.


Treatment of rheumatoid arthritis with immunosuppressive drugs. II. Immunological study.


Cardiac and peripheral vascular effects of lidocaine and procainamide.


A new method of assessing the state of charge of implanted cardiac pacemaker batteries.


Pulmonary valvular and infundibular atresia with intact ventricular septum.


Ethacrynic acid. Use in ambulatory patients with resistant edema.


Coexistent aortic and mitral atresia associated with persistent common atrioventricular canal.


Congenital mitral and tricuspid stenoses.


Sustained atrioventricular conduction delay due to interpolated ventricular premature systole.


Patients, psychotherapists, and socioeconomics.


"MCFT": simultaneous treatment of several families.


When patients commit suicide.

When patients commit suicide.


Pitfalls in the methodology of the Law of Initial Value.


Depression in the officer patient.

Depression in the officer patient.


The cultural context of Japanese psychiatry and psychotherapy.


The problem of termination of psychotherapy.


Passivity and psychotherapy.

Passivity and psychotherapy.


Countertransference reactions to college drop-outs. Value of group supervision.


The psychotherapy of two Nigerian students.


The delinquent's escape from conscience.


Anti-Negro prejudice before, during, and after an acute schizophrenic episode in a white woman. Brief clinical report.


The psychodynamics of a drug addict. A three-year study.


The mechanism of antagonism between antigenic types of dysentery bacilli of the Shigella flexneri subgroup.


Opsonizing factors in rat serum. I. Serum components stimulating phagocytosis of Staphylococcus aureus.


Opsonizing factors in rat serum. 3. Inhibitor and phagocytosis-stimulating factor for S. sonnei phase II bacilli.


An attempt to identify the components of complement in rat serum immunoelectrophoretically.


The VMK variant of a strain of Poxvirus officinale. I. Morphology of HeLa cells infected with the VMK virus.


The influence of phosphorolysis on hydrolysis of glycogen in muscle extracts.


Microfluoroscopic studies on porphyrins in Harder's gland and in tumors induced in it. 3. Histotopography of porphyrins and growth of transplanted sarcoma in Harder's gland in white rats.


Morphologic changes in the pulmonary parenchyma after single irradiation with small doses of x rays.


Methods of calculating oxygen consumption by tissues in the fatty liver of white rats.


Diffusion and impaired gas exchange.

Diffusion and impaired gas exchange.


Chronic diffuse idiopathic fibrosing alveolitis.


Rheumatoid interstitial lung disease.

Rheumatoid interstitial lung disease.


A survey of mycobacteria isolated at a South London chest hospital.


Anti-asthmatic properties of anti-snake-venom serum.


Ethionamide 1,000 mG. and isoniazid 400 mG. in previously untreated cases of pulmonary tuberculosis.


Enzyme-biological synthesis of a cancerigenic agent ("cancervirus") starting from nucleotides. V. Molecular biology and genetical studies.


A new method for culturing amnion cells.


Experimental amyloidodis in immunity.

Experimental amyloidodis in immunity.


Nutritional studies on some members of the mucorales. V. 1. Utilization of different nitrogen compounds.


Studies on the combined action of stilbamidine and penicillin in experimentally induced bacterial endocarditis.


The effect of lysergic acid diethylamide (LSD-25) on perception with stabilized images.


Interaction between iminodibenzyl-derivatives or phenothiazine-derivatives and methamphetamine in the rat.


Potentiation of barbital hypnosis as an evaluation method for central nervous system depressants.


The effects of methamphetamine and pentobarbital on the running memory span.


Psychodynamic factors in the mother-child relationship in adolescent drug addiction: a comparison of mothers of schizophrenics and mothers of normal adolescent sons.


Aetiological patterns in delinquent adolescents, a survey of 66 cases seen at the Portman Clinic 1961-1964.


Love- and hate-addiction in delinquent male adolescents.


The psychotherapy of puberal crises from the point of view of their subsequent development.


The experience of puberty and some implications for psychotherapy.


A psychoanalytical approach to work with adolescents. The work of the young people's consultation centre (London) with remarks on diagnosis and technique.


Coronary heart disease and behavior patterns. An examination of method.


Corticosteroid excretion in normal young adults living under "basal" conditions.


Implementing an adolescent service in an ongoing mental hospital.


The beginnings of the growth and development of an adolescent unit in the Cassel Hospital.


Individual observations during psychoanalytic group therapy with adolescents.


The quantification of "response" to experimental stimuli.


Brain norepinephrine and behavior. A behavioral and kinetic study.


Electroencephalographic and autonomic activity during and after prolonged sleep deprivation.


Individual differences in autonomic responsivity. Problems of measurement.


Messenger RNA in early sea-urchin embryos: cytoplasmic particles. Three structures containing messenger RNA can be demonstrated in the cytoplasm of early sea-urchin embryos: (i) particles that sediment more slowly than ribosomes and contain newly synthesized DNA-like RNA, (ii) light polyribosomes, which also contain this newly synthesized RNA, and (iii) heavy polyribosomes, which seemingly contain only already existing or "maternal" messenger RNA and account for the bulk of the synthesis of protein.


Messenger RNA in early sea-urchin embryos: size classes. Rapidly labeled RNA from four-cell embryos and blastulae of sea urchins was analyzed by sedimentation and for ability to form DNA-RNA hybrids. The RNA was derived from polyribosomes and from the "gel interphase," an extraction compartment resulting from treatment of whole embryos with phenol and known to be enriched with nuclei. The RNA from both sources displayed a high degree of structural complementarity to DNA. This DNA-like RNA of the polyribosomes sedimented in discrete classes, rather than in the sedimentation continuum demonstrable for the labeled RNA of the gel interphase. Thus messenger RNA appears to emerge in the cytoplasm in discrete size classes.


Bone density measurements in vivo: improvement of x-ray densitometry. An X-ray bone densitometer has been developed which makes direct tracings of absorption curves on a nearly linear scale. Speed and precision are increased by elimination of x-ray film. Results are reproducible to within 3 percent with a phantom finger, and within 6 percent with human subjects.


Protein solutions: concentration by a rapid method. Protein solutions were concentrated, with no evidence of denaturation, by means of membranes formed from the complex interaction product of polyanions and polycations (Diaplex). The technique is considerably more rapid than conventional ultrafiltration with Visking tubing.


The haemolytic-uraemic syndrome. A report of two cases.


Some aspects of hospital planning.

Some aspects of hospital planning.


Leg elevator for chronic oedema.

Leg elevator for chronic oedema.


A case of small bowel perforation.

A case of small bowel perforation.


Bleeding oesophageal varices in the absence of intrahepatic or extrahepatic obstruction of the portal system and without portal hypertension.


Osteomalacia following gastrectomy.

Osteomalacia following gastrectomy.


Address at special graduation ceremony in Queen's University for the British Dental Association meeting on 23rd June, 1965.


Cancer of the breast. Results of treatment in Northern Ireland, 1955-1959.


Health problems of adolescence.

Health problems of adolescence.


Hospital organization in developing countries.


The WHO programme in nutrition, 1948-1964. 2.


International non-proprietary names for pharmaceutical preparations.


A study on supratentorial meningiomas. With special reference to gross and fine structure.


Localization of myofibrillar potassium with sodium tetraphenylborate.


Adrenal blood flow and corticosteroid secretion. II. The effect of oxytocin on adrenal blood flow and corticoid secretion before and after acute hypophysectomy in the dog.


The effects of heat and humidity on the human skin.


Sweat-gland training by drugs and thermal stress.


The human eccrine sweat gland. Structural and functional interrelationships.


Hidromeiosis.

Hidromeiosis.


Vascular and sweating responses to regional heating.


Mechanism of sweating in work.

Mechanism of sweating in work.


The factor of temperature in ultraviolet injury.


Cold injury of the skin. The pathogenic role of microcirculatory impairment.


Response of human epidermis to graded thermal stress. A morphologic comparison of burns, cold-induced blisters, and pemphigus vulgaris.


Stress-relaxation of stretched callus strips. Influence of various solvent and solution environment on mechanoelastic properties of cornified epithelium.


Keratin and the barrier. A human epidermal phospholipoprotein with water barrier properties.


The effects of wetting on cutaneous vulnerability.


Percutaneous absorption. Influence of temperature and hydration.


Pulmonary dynamics and retention of toxic gases.I. Sulfur dioxide: concentration and duration effects in rats.


Respiratory exposure to organic phosphorus insecticides. Observations on effectiveness of respiratory protection in preventing poisoning from occupational exposure to parathion and 2-carbomethoxy-1-methylvinyldimethyl phosphate.


Absorption and excretion of mercury in man. 8. Mercury exposure from house paint--a controlled study on humans.


Complications of tracheotomy.

Complications of tracheotomy.


Methylation of adenine in deoxyadenylic acid or deoxyribonucleic acid at N-7.


Vitamin A acid from retinene.

Vitamin A acid from retinene.


Improved rates of carbon dioxide fixation by illuminated chloroplasts.


Effect of cysteine on respiration and catalyse synthesis by Saccharomyces cerevisiae.


The formation of polyphenols in trees. 2. The polyphenols of Eucalyptus sieberiana kino.


The fatty acid composition of intestinal-lymph lipids in sheep and lambs.


Studies on metabolism of vitamin A. 7. Lowered biosynthesis of ascorbic acid in vitamin A-deficient rats.


Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats.


The activation of L-threonine dehydrogenase by potassium ions.


Condensed tannins. 19. Configuration of diol groups in flavan-3,4-diols by paper chromatography and paper ionophoresis.


Condensed tannins. 20. Chromophoric properties of flavan-4-ols, flavan-3,4-diols and condensed tannins.


Aminotransferases of Agrobacterium tumefaciens. Transamination between tryptophan and phenylpyruvate.


Metabolism of palmitate in sheep.

Metabolism of palmitate in sheep.


Metabolism of polycyclic compounds. 25. The metabolism of anthracene and some related compounds in rats.


The metabolism of acetophenetidine. Isolation and characterization of S-(1-acetamido-4-hydroxyphenyl)-cysteine, a metabolite of acetophenetidine.


Transamination of peptides.

Transamination of peptides.


The effect of 2-amino-2-methylpropanol on rat-liver mitochondria.


Effect of dietary sulfur upon the fatty acid production in the rumen.


The biological oxidation of 2,2-dimethyloctanoic acid.


Alterations in phospholipid metabolism induced by ethanol administration.


The acylation of lysophosphatides with long-chain fatty acids by rat brain and other tissues.


Quantitative study of the pathways of triglyceride synthesis by hamster intestinal mucosa.


Metabolism of plasmalogen. 3. Relative reactivities of acyl and alkenyl derivatives of glycerol-3-phosphorylcholine.


Triglyceride biosynthesis from monoglycerides in isolated segments of intestinal mucosa. Utilization of an ether analogue of 2-monostearin.


The action of phospholipase C on muscle microsomes: a correlation of electron microscope and biochemical data.


Isolation and separation of inositol phosphates from hydrolysates of rat tissues.


Studies on the production of sphingolipid bases by the yeast, Hansenula ciferri.


Investigation of the lipid content of normal and glucose-6-phosphate dehydrogenase deficient red cells.


Function of specific bile acids in cholesterol esterase activity in vitro.


Gas-liquid chromatographic analysis of the tissue sterol fraction in Wolman's disease and related lipidoses.


The spontaneous degradation of a tritiated glyceryl ether.


Effects of inorganic iron on the thiobarbituric acid method for determination of lipid peroxides.


Enzymes of lipid synthesis in the liver of the cortisone-treated rat.


On the anabolism of lysolecithin.

On the anabolism of lysolecithin.


On the positional specificity of phospholipase A from pancreas.


A monoglyceride-splitting enzyme of rat and hog liver.


Beta-aminoisobutyric acid: a thin-layer chromatographic method for the quantitative estimation in human urine.


Gas chromatography of urinary vanilmandelic acid in pheochromocytoma.


The content of free and bound amino acids in urine in postoperative periods.


Estimation of pregnanediol and pregnanetriol in urine.


Catalytic acceleration of the urea-diacetylmonoxime-phenazone reaction and its application to automatic analysis.


Quantitative filter paper electrophoresis by means of reflectance densitometry.


The activities of several enzymes of mucosa, carcinomata and polyps of human colon.


The latent emulsifying capacity of human serum.


An automated procedure for the determination of serum haptoglobin.


The formation of haemiglobin using nitrites.


Lactic dehydrogenase isoenzyme determination: effect of incubation temperature.


Plasma albumin loss due to bronchopathy.


The gas chromatography of pregnane series steroids.


Glomectomy.

Glomectomy.


The "emergency room".

The "emergency room".


Screening for glaucoma.

Screening for glaucoma.


Dangers of hypnosis.

Dangers of hypnosis.


Bacterial interference.

Bacterial interference.


Sixty-five and over. 1. How does he view himself?


Hyperthermia from dicyclomine hydrochloride.


Lip reconstruction.

Lip reconstruction.


A propos of chemical radioprotection. (Agreements and disagreements of different tests).


A method for measuring facial bone growth in three dimensions.


Liquid scintillation counting of H2S35O4 with glass fibre paper.


The influence of seed treatment with gamma radiation on plant yield.


Optimum window setting in a spectrometer for low-level activity counting.


Synthesis of S35-p-toluene sulphonic anhydride (Tosan) of high specific activity.


Hydrazine formation in the fission-fragment radiolysis of liquid ammonia.


Analysis of oxygen-18 in carbon dioxide by thermal neutron activation.


Computer programs for calculation of liquid scintillation counting data.


Rapid determination of Sr89 and Sr90 in a mixture.


A routine method for determination of C-14 by liquid scintillation.


Preacclimatization of men to heat by training.


Effects of core temperature upon duration of hibernation Citellus lateralis.


Temperature regulation and cold acclimation in the golden hamster.


Thermoregulation and cold acclimation in a hibernator, Citellus tridecemlineatus.


Cytologic cyclic surveys.

Cytologic cyclic surveys.


Tracheal motion during eupnea.

Tracheal motion during eupnea.


The treatment of uterine synechiae with the help of iatrogenic pseudopregnancy. Anatomic and functional results.


Initial hemodynamic responses to mild exercise in trained dogs.


Dissimilar distribution of calcium isotopes in blood serum and urine.


Stability of cerebrospinal fluid pH in chronic acid-base disturbances in blood.


Lung function and blood-gas exchange, before and after cardiac surgery.


Increase in breathing frequency following the reflex deep breath in anesthetized cats.


Pulmonary vasoconstriction during histotoxic hypoxia.


Electrode size and tissue pO2 measurement in rats exposed to air or high pressure oxygen.


Oxygen uptake and change in carbon dioxide tension in human blood stored at 37 C.


Demonstration of bile stasis in the mouse by a direct and an indirect method.


Cholesterol metabolism. II. Quantitative measurement of cholesterol absorption.


A stimulating electrode for nerves.

A stimulating electrode for nerves.


Metabolism and the protection by anesthesia against toxicity of O2 at high pressure.


Postcesarean infertility.

Postcesarean infertility.


Thermal dilution: instrumentation with thermistors.


A rate signal interpreter.

A rate signal interpreter.


An apparatus for production of gas mixtures of controlled composition.


Continuous sampling of arterial blood of unanesthetized animals.


Continuous recording of C-14-O2 excretion and O2 consumption by rats.


A digital integrator for on-line pulmonary compliance measurements.


Design and performance characteristics of a respiratory valve for the dog.


Impedance measurement of tidal volume and ventilation.


An electro-optical meniscus-sensing system for a pressurized flush bottle.


A system for providing surgical anesthesia for germfree rodents.


Treadmill for small laboratory animals.

Treadmill for small laboratory animals.


Some responses of humans to thermal radiation.


Skin and subcutaneous temperature changes during exposure to intense thermal radiation.


Skin temperature and cutaneous pain during warm water immersion.


Renal function in high-altitude natives and in natives with chronic mountain sickness.


Decompression sickness following repeated breath-hold dives.


Splanchnic metabolism in exercising man.


Effect of an anabolic steroid on physical performance of young men.


Effects of aspirin on detection and tolerance of electric shock.


Solubility of krypton and xenon in blood, protein solutions, and tissue homogenates.


Microphotoelectric plethysmography using a rabbit ear chamber.


Blood O2 content measurements using the oxygen electrode.


Indirect determination of maximal O2 consumption in man.


Responses of oxygen electrodes to variables in construction, assembly, and use.


Pulsatile flow in rigid tubes.

Pulsatile flow in rigid tubes.


Permanent physiological fistula of the pancreas and other digestive glands.


Phase-sensitive detector-type electromagnetic flowmeter.


A hot-wire microanemometer for measurement of air movements inside clothing.


Method for recording ECG's in unanesthetized guinea pigs.


An electromyographic electrode designed for identification of recording sites.


A strain-gage platform for force measurements.


Continuous duty tonometer system.

Continuous duty tonometer system.


A student laboratory exercise illustrating active transport across the small intestine.


Intrapulmonary exchange of the stable isotope 18O2 injected intravenously in man.


Alveolar dead space, alveolar shunt, and transpulmonary pressure.


Normal respiratory and circulatory values in the cat.


Effect of CO2 and whole-body vibration on ventilation.


Analysis of ventilatory response to CO2 during hypoxia in dogs.


Effect of vertical vibration on respiratory airflow and transpulmonary pressure.


Effect of oxygen breathing at atmospheric pressure on pulmonary surfactant.


Effects of atelectasis on pulmonary surfactant and quasi-static lung mechanics.


Pulmonary diffusing capacity in man during immersion in water.


Increase of arterial oxygen tension at altitude by carbonic anhydrase inhibition.


In vivo and in vitro CO2 blood buffer curves.


Concept and measurement of ventilatory sensitivity to carbon dioxide.


Respiration and cerebrospinal fluid pH in metabolic acidosis and alkalosis.


Effect of temperature on deoxygenation rate of human red cells.


Venous admixture in dogs with chronic pulmonary hypertension.


Effects of compression on composition and absorption of tissue gas pockets.


Changes in the aerobic capacity and body composition in obese boys after reduction.


Influence of age and sex on exercise cardiac output.


Pressure-flow relations of human blood in hollow fibers at low flow rates.


Effect of local exercise of forearm muscles on forearm capacitance vessels.


Cardiovascular and sweating responses to water ingestion during dehydration.


Human eccrine sweat gland activity and palmar electrical skin resistance.


Initiation of sweating in man after abrupt rise in environmental temperature.


Development of a criterion for physical fitness tests from factor analysis results.


Pseudosubluxation and other normal variations in the cervical spine in children. A study of one hundred and sixty children.


Biosynthesis of prostaglandins from arachidonic acid in guinea pig lung. Prostaglandins and related factors. 38.


Subtalar extra-articular arthrodesis for correction of paralytic valgus deformity of the foot. Evaluation of forty-four procedures with particular reference to associated tendon transference.


An evaluation of pantalar arthrodesis. A follow-up study of one hundred and sixteen operations.


Correction of wrist deformity in diaphyseal aclasis by stapling. Report of a case.


Vertical transarticular-pin fixation for unstable ankle fractures.


Deep ulnar-nerve paralysis resulting from an anatomical abnormality.A case report.


Locked index finger caused by hyperflexion and entrapment of sesamoid bone.


Popliteal aneurysm complicating benign osteocartilaginous exostosis.Review of the literature and report of one case.


Interarticular horizontal dislocation of the patella. A case report.


Anomalous muscles simulating soft-tissue tumors in the lower extremities. Report of three cases.


Spontaneous amputation of gangrenous leg.


A successful fracture table for the accident room.


Juxtacortical chondroma. A case report.

Juxtacortical chondroma. A case report.


Teflon hip prostheses in dogs.

Teflon hip prostheses in dogs.


Elbow reconstruction with a new prosthesis to replace the distal end of the humerus. A case report.


A comparative study of isometric and isotonic quadriceps exercise programs.


Tendon transfers about the foot, ankle, and hip in the paralyzed lower extremity.


Tumors of the larynx. (3). The place of radiotherapy in the management of laryngeal cancer.


Tumours of the larynx. (1). Surgery.

Tumours of the larynx. (1). Surgery.


Tumors of the larynx. (2). Diagnostic radiology.


The Cryptococcus reviewed.

The Cryptococcus reviewed.


Traumatic pulmonary fat embolism.

Traumatic pulmonary fat embolism.


The clinical approach to certain post-nataly acquired causes of mental retardation.


Observations on hepatic acidity for folate in Laennec's cirrhosis.


Tetracycline-induced abortion in the rat.


The attachment of microorganisms to epithelial cells in the distal ileum of the mouse.


The influence of copper and molybdate salts on the production of bony deformities in rats.


An electron microscopic study of the effects of chronic hypoxia on cardiac muscle, hepatic, and autonomic ganglion cells.


Deoxyribonucleic acid assessments on Feulgen-stained endometrial cells and comparison with fluorometric values on acridine-orange stained material.


Effects of immune serum and spleen cells on C3Hf/He tumor graft survival in Tennessee Swiss mice.


Size of baby and size of family in prediabetes.


Correlation between ketone body and free fatty acid concentrations in the plasma during early starvation in man.


Alterations in adrenal cortical function in fasting obese subjects.


The relationship between level of triglycerides in plasma and number of basophils in blood.


Insulin resistance in hyperglyceridemia.


Protein utilization and changes in body composition during weight reduction.


Plasma free oleic and palmitic acid levels during vigorous exercise.


Calcium kinetics in vitamin D deficiency rickets. I. Plasma kinetic studies after intravenous and oral Ca47.


Calcium kinetics in vitamin D deficiency rickets. II. Intestinal handling of calcium.


Mechanism of testosterone action in erythropoiesis.


Monoamine oxidase and acetylcholinesterase activity in animals with experimental allergic encephalomyelitis.


The effect of adrenalectomy on adaptation to hypoxia in the rat. Changes in hemoglobin concentration and osmotic resistance of erythrocytes in peripheral blood.


Radiography in Ludhiana.

Radiography in Ludhiana.


Programmed learning. The Society and a new teaching method.


Closed-circuit television in radiography.


Torsion of the adnexa: experience with 15 cases.


A rapid actinometer for photochemical air pollution studies.


Generation and determination of ozone in low concentrations.


Waste treatment for ground water recharge.


Thermodynamics of biological synthesis and growth.


Sewage pollution and sea bathing.

Sewage pollution and sea bathing.


Predicting the condition of a polluted estuary.


A survey of the pollution of the Sumida River, especially on the aromatic amines in the water.


The pathogenesis of secondary brainstem hemorrhages as studied in an experimental model.


The fine structure of cerebral fluid accumulation. IX. Edema following silver nitrate implantation.


Ultrastructural studies of intranuclear crystalline inclusions in the liver of the dog.


An ultrastructural study of spontaneous lupus nephritis in the NZB-BL-NZW mouse.


Action of 2-deoxy-D-glucose on frog gastric mucosa.


Inhibition of active intestinal sugar transport by digitalis.


Dietary production and dissolution of cholesterol gallstones in the mouse.


Comparison of rat salivas evoked by auriculo-temporal and pilocarpine stimulation.


Biological activity and fate of trace quantities of intravenous chromium (3) in the rat.


Heat production of tropical snakes in relation to body weight and body surface.


Induced change in heart metabolism as a primary determinant of heart performance.


Systolic pressure gradients across the aortic valve and in the ascending aorta.


Carotid chemoreceptor stimulation and ventricular performance.


Effect of hemoglobin type on the cardiorespiratory system of sheep.


Descending respiratory pathways in the medulla oblongata of the cat.


Appearance of excess lactate in anesthetized dogs during anemic and hypoxic hypoxia.


Selective effect of insulin on glucose-U-C14 metabolism in rabbit liver slices.


Hypothalamic obesity in weanling rats.

Hypothalamic obesity in weanling rats.


Hereditary obesity and hormone deficiencies in yellow dwarf mice.


Effect of vitamin D and dietary calcium on parathyroid activity.


Evidence for a direct effect of parathyroid hormone on urinary acidification.


Micropuncture study of proximal renal tubular chloride transport during hypercapnea in the rat.


Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs.


A method for exposing the rat renal medulla in vivo: micropuncture of the collecting duct.


Toxicological certification of fatal melipramine poisoning in a child.


The influence of low temperature on acetylcholine and potassium sensitivity of the superior cervical ganglion.


Steatorrhea complicating diabetes mellitus.


Autoradiographic studies on intracytoplasmic multiplication of Toxoplasma gondii in FL cells.


Studies on the combined use of killed and live measles vaccines. I. Correlation between antibody titers following injection of killed vaccine and clinical reactions after live vaccine inoculation.


Studies on the combined use of killed and live measles vaccines. II. Advantages of the inhalation method.


Studies on the serological standardization of measles virus.


The use of mice in potency assays of inactivated measles virus vaccines.


Enzymic synthesis of ricinoleic acid by extracts of developing Ricinus communis L. seeds.


Investigation of pi-bonding in enzymic reactions. I. Enzyme-substrate complex between catechol and tyrosinase.


Specific cleavage of C-methionyl peptide bonds in hydrogen fluoride.


Stereoselectivity of norepinephrine storage sites in heart.


Succinyl-phosphatides as intermediates in the succinate-dehydrogenase reaction of yeast.


Plastochromanol in the leaves of Hevea brasiliensis.


Studies on autobiotics: retine in human urine.


The linkage between the polysaccharide and mucopeptide components of the cell wall of Lactobacillus casei. 1. The linkage between the polysaccharide and mucopeptide components of the cell wall of Lactobacillus casei is rapidly hydrolysed under mild acid-hydrolysis conditions. 2. The release of the polysaccharide is accompanied by the hydrolysis of an N-acetylhexosaminide linkage. The N-acetylhexosamine residue readily forms chromogen and it is concluded that it is substituted on C((3)) by the adjacent sugar. 3. Continued heating of the polysaccharide in acid results in a slower release of reactive N-acetylhexosamine due to the hydrolysis of glycosidic linkages within the polysaccharide. 4. After the linkage between the polysaccharide and mucopeptide has been hydrolysed, acid phosphatase will release approx. 40% of the total phosphorus as inorganic phosphate. 5. It is concluded that the polysaccharide component of the cell wall is joined through its reducing end group to a phosphate grouping in the mucopeptide.


Properties of the polysaccharide and mucopeptide components of the cell wall of Lactobacillus casei. 1. The polysaccharide and mucopeptide components of the cell wall of Lactobacillus casei have been separated by mild conditions of acid hydrolysis. 2. Removal of the polysaccharide renders the mucopeptide susceptible to lysozyme. 3. The mucopeptide and polysaccharide components have been analysed and the results compared with those obtained previously. 4. The polysaccharides responsible for group specificity have a terminal reducing N-acetylgalactosamine residue substituted on C((3)) by the adjacent sugar; estimation of this component gave an indication of the molecular weight of the polysaccharides. 5. Evidence has been obtained for the presence of rhamnosyl-(1-->3)-N-acetylgalactosamine among the products of acid hydrolysis of the group B polysaccharide.


Intestinal metabolism of fatty acids.

Intestinal metabolism of fatty acids. 1. The effect of concentration on the oxidation and incorporation into lipids of lauric acid and linoleic acid by rings of rat small intestine has been studied in vitro. 2. In the absence of glucose, the oxidation of lauric acid in the range 0.01-5.0mm showed a maximum at 0.1mm. In the presence of glucose the maximum was at 0.5mm. The oxidation of linoleic acid in the presence of glucose increased throughout the concentration range 0.01-5.0mm. 3. The incorporation of lauric acid into lipids was maximal at 0.5-0.6mm in the presence of glucose, but at 10mm in the absence of glucose. At 0.8mm-lauric acid, in the presence of glucose, over 75% of the incorporated lauric acid was in triglycerides, but at 10mm they only contained 30%. The incorporation of glucose carbon into glycerides paralleled the incorporation of lauric acid. 4. In the range 0.01-2.5mm-linoleic acid the quantity incorporated into lipids increased. In the range 0.01-0.4mm linoleic acid was incorporated predominantly into triglycerides, but between 0.4 and 1.0mm most was in diglycerides, and between 2.5 and 5.0mm most was in monoglycerides. 5. The relationship of fatty acid concentration to the mechanism of absorption is discussed, together with the correlation between the distribution of the absorbed fatty acids within the tissue lipids and the lipase activity of intestinal mucosa.


Tritiated starch granules.

Tritiated starch granules. 1. Surface-labelling of starch granules by tritiation seems feasible, and a technique is described that could be useful in structure determination. The impurities that are produced must be taken into account but the fact that a high polymer can be successfully tritiated seems very promising. 2. The surfaces of corn-starch granules must contain both amylose and amylopectin.


Induction and multi-sensitive end-product repression in two converging pathways degrading aromatic substances in Pseudomonas fluorescens. 1. Control of enzyme formation has been examined in the pathways degrading mandelate and p-hydroxymandelate in Pseudomonas fluorescens. 2. The first three enzymes form a group which is common to both pathways and which is co-ordinately induced or repressed. The genes controlling these enzymes are assumed to form a ;regulon'. This group of enzymes is induced by mandelate or p-hydroxymandelate and repressed by benzoate and by p-hydroxybenzoate (the immediate end products resulting from the action of this group of enzymes). 3. Repression is independently exerted by end products of enzymes controlled by succeeding regulons, i.e. by catechol, by protocatechuate and finally by succinate and acetate. 4. The pattern is repeated further along the pathway, so that benzoate oxidase (controlled by the second regulon) is repressed by its immediate end product, catechol, and again by succinate and acetate. 5. Pyrocatechase, an enzyme controlled by the third regulon, is repressed by succinate and acetate. 6. There is a parallel system of multi-sensitive repression mechanisms controlling production of the enzymes that degrade the hydroxy compounds. Again, the enzymes of each regulon are repressed by the immediate end product of their action and by the end products of each succeeding group of enzymes. 7. Repressor activity appears to be exerted by compounds that are likely to occur as such in the external environment or that occur at points of convergence of the degradative pathways of the cell. 8. The net effect of this control system, involving both induction and end-product repression, appears to be that cells will not form inducible degradative enzymes if the end products are already being supplied from without or are being produced by degradation of some alternative source of carbon and energy.


Haemoglobins of invertebrate tissues. Nerve haemoglobins of Aphrodite, Aplysia and Halosydna. 1. The occurrence of haemoglobin in invertebrate nerves is surveyed. Haemoglobin was observed in the nerves and ganglia of the marine nematode Amphiporus sp. and of the polychaet annelid Halosydna sp. 2. Haemoglobins from the nerve and ganglia of the polychaet annelid Aphrodite aculeata L. and from the nerve of the gastropod mollusc Aplysia californica have been partially purified. The haem in each case was identified as iron protoporphyrin IX. 3. The minimum molecular weight of Aphrodite nerve haemoglobin deduced from the haem content and amino acid analysis is 17090, in agreement with the molecular weight 15600+/-1000 determined by sedimentation equilibrium. 4. The molecular weight of Aplysia nerve haemoglobin was determined by sedimentation equilibrium to be 16400+/-1000. 5. The oxygen dissociation curves are hyperbolic. Half-saturation is achieved at 1.1mm. Hg for Aphrodite nerve haemoglobin and at 4.0mm. Hg for Aplysia nerve haemoglobin. The coefficients for partition between carbon monoxide and oxygen are: Aphrodite nerve haemoglobin, 167; Aplysia nerve haemoglobin, 116. 6. The ferrous haemoglobins combine with cyanide. 7. We conclude that the intracellular haemoglobins of muscle and nerve are similar.


Ovoglycoprotein, a protein of hen's-egg white. 1. A description is given of the isolation of a glycoprotein from hen's-egg white; it has been called ovoglycoprotein. 2. It contains 13.6% of hexose, 13.8% of hexosamine and 3% of sialic acid. 3. Hexose occurs as mannose and galactose in the ratio 2:1, hexosamine as glucosamine and sialic acid as N-acetylneuraminic acid. 4. It has S(20,w) 2.47s and a minimum molecular weight, calculated from the tryptophan content, of 24400. 5. At pH3.9 in acetate buffer, I0.1, which is in the isoelectric region, it is resolved into two components, one of which moves slowly towards the anode while the other moves slowly towards the cathode.


Pyruvate metabolism by a nitrogen-fixing bacterium. 1. The major products of pyruvate dissimilation by washed intact cells of Achromobacter N4-B under nitrogen-fixing conditions are acetate and formate. The formation of succinate and isocitrate and the assimilated amino acids requires carbon dioxide fixation. 2. The products formed by cells incubated with pyruvate in an atmosphere of nitrogen were compared with those formed by cells incubated in an atmosphere of helium. Production of hydrogen and the formation of succinate were greater under helium than under nitrogen. Production of acetate and formate and the utilization of pyruvate were the same in both atmospheres. 3. Cell-free preparations, unlike intact cells of Achromobacter N4-B, do not evolve hydrogen, but do produce lactate. 4. It is suggested that, in cell-free preparations incapable of fixing nitrogen, electrons are accepted from pyruvate to form lactate rather than being used for the reductive formation of ammonia and hydrogen.


The effect of treatment of rats with pituitary growth hormone on the activities of some enzymes involved in fatty acid degradation and synthesis. 1. Measurements have been made of the activities of acyl-CoA dehydrogenase, enoyl-CoA hydratase, beta-hydroxyacyl-CoA dehydrogenase and ketothiolase in the livers of rats treated for either 12hr. or 3 days with pituitary growth hormone. 2. There was a significant increase in the activity of acyl-CoA dehydrogenase in rats treated with the hormone for 3 days. 3. Measurements were also made of the lipogenic enzymes acetyl-CoA carboxylase and palmitate synthase in the livers of similarly treated animals. 4. There was a depression of the activity of both enzymes after 12hr. treatment and a further decline after 3 days. 5. The results are discussed in relation to the known increase in the rate of fatty acid oxidation and inhibition of fatty acid synthesis in rats treated with growth hormone.


The composition and physicochemical properties of hyaluronic acids prepared from ox synovial fluid and from a case of mesothelioma. 1. Materials containing hyaluronic acid have been prepared by filtration (Ogston & Stanier, 1950) from ox synovial fluid and from a protein-rich human mesothelioma fluid. The ox material has been deproteinized by treatment with chloroform and pentanol and by gradient elution on DEAE-Sephadex; several fractions were obtained by the latter method. These materials can be stored in solution at -20 degrees without change of properties. The ox material contained 21% of protein; all other preparations contained less than 6% of protein. 2. The two materials have been compared by sedimentation and viscosity and shown to be closely similar. Treatment of the ox material with neuraminidase caused no change in its viscosity behaviour. 3. Information about the molecular configuration of the ox material has been obtained from measurements of light-scattering and viscosity. The results, though consistent with a highly extended configuration, are not consistent with a linear random-coil configuration. It is tentatively suggested that the structure may have some degree of branching and of cross-linking, which give it a rigidity with respect to expansion of the molecular domain that would not be possessed by a random coil. 4. The deproteinized material recovered from DEAE-Sephadex, though polydisperse, showed unchanged average molecular weight; however, the average radius of gyration was greater than before this treatment. 5. Acidification to approx. pH3 resulted in a contraction of the structure, with only a slight degree of expansion when the pH was restored to 6.8-7.0. 6. Measurements of optical rotatory dispersion qualitatively support a structure less simple than a linear random coil. 7. Colloid osmotic pressures of mixed solutions of bovine serum albumin and of hyaluronic acid prepared by filtration from ox synovial fluid have been measured. The results agree approximately with those of Laurent & Ogston (1963) but are in quantitative disagreement with the partition measurements of Ogston & Phelps (1960). The relationships between thermodynamic quantities in a quaternary system of electrolytes are discussed in Appendix 2. 8. Refractometric measurements have been made in connexion with light-scattering measurements, as the basis for a convenient method of determining the concentrations of solutions of hyaluronic acids, and to measure the partition of sodium chloride in dialysis experiments. The theory of the last use is discussed in Appendix 1. 9. Sedimentation measurements on the ox preparation have been made up to a concentration of 1.4x10(-2)g./ml. The form of the sedimentation coefficient-concentration relationship is discussed. The value of the sedimentation coefficient at higher concentration is the basis of an illustration of the likely effect of hyaluronic acid on the flow of water through narrow channels in connective tissue. 10. Available colorimetric methods have been shown to give low estimates for glucuronic acid when applied to highly polymerized materials, as compared with estimates by decarboxylation. A spectrophotometric titration with cetylpyridinium bromide has been shown to give estimates of carboxyl groups that agree well with those of decarboxylation when applied to preparations of hyaluronic acid under suitable conditions; the results are not affected by the presence of protein. 11. Estimates of glucosamine (Ogston, 1964) have been found to be low compared with those of total acetyl, independently of the presence of protein. The magnitude of the discrepancy is characteristically different for preparations from ox synovial fluid and from mesothelioma. 12. Sialic acid was estimated in several preparations. It is likely that this forms part of the protein. 13. Analyses of preparations for total nitrogen, amino acids, total acetyl, glucuronic acid (by decarboxylation) and ash account for at least 95.7% of the dry weight in terms of N-acetylglucosaminyl, glucuronyl, protein and metal ions. Previously published analyses of hyaluronic acids are reviewed. 14. The estimated molar ratios of glucuronic acid to glucosamine were all significantly greater than unity. 15. The analytical results are interpreted as agreeing with the physicochemical measurements in suggesting a more complex structure, for at least some hyaluronic acids, than that of an alternate linear copolymer in random-coil configuration.


A computer programme for the calculation of the results of amino acid analysis. 1. An ALGOL computer programme is presented for the calculation of the results of amino acid analysis. 2. The suggestion is made that a similar approach could be made to other tedious and repetitive biochemical calculations.


Changes in lysosomal enzymes in acute experimental liver injury. 1. An investigation has been made of the changes occurring in lysosomal enzyme activities during the early development of experimentally produced liver injury in the rat. Three enzymes have been studied: acid phosphatase, acid ribonuclease and beta-glucuronidase. Four different methods of inducing liver injury have been used: administration of carbon tetrachloride, thioacetamide, dimethylnitrosamine and the fungal toxin sporidesmin. 2. The majority of the data presented concern alterations produced by carbon tetrachloride. Despite the extensive central necrosis and accompanying fat accumulation which this poison produced in the liver, only small changes in the activity and latency of lysosomal enzymes could be detected. In the early (pre-necrotic) period of injury these changes were insignificant. At a late stage of injury, when extensive centrilobular necrosis was present, there were indications of lysosomal rupture. 3. The results obtained with the other three hepatotoxins were similar to those described for carbon tetrachloride in that no evidence of early lysosomal rupture was obtained during the pre-necrotic period. It is concluded that lysosomes probably play no role in the early development of the four types of liver injury studied but, instead, are involved in later scavenging processes.


Incorporation of 14C-labelled fatty acids into the mammary-gland lipids of the lactating rabbit. 1. [1-(14)C]Stearic acid, [9-(14)C]stearic acid, [9-(14)C]palmitic acid and [9-(14)C]decanoic acid were fed to lactating rabbits, and the fatty acids of the mammary gland were separated and partially degraded. 2. Most of the (14)C recovered was located in the acids fed. Stearic acid was least efficiently absorbed; decanoic acid was the most extensively metabolized. 3. Resynthesis after degradation to C(2) units led to uniform alternate labelling in the C(2)-C(10) acids, whereas C(12)-C(18) acids had excess of (14)C at the carboxyl end. 4. Acids formed by beta-oxidation down to C(12), but not below, were also present in the mammary-gland lipids. Desaturation of the administered acids was a very minor reaction.


The biosynthesis of streptomycin. The origin of the C-formyl group of streptose. 1. The biosynthesis of streptomycin in Streptomyces griseus has been studied by adding d-[3,4-(14)C(2)]glucose or d-[1,3-(14)C(2)]glucose to the growth medium and degrading the streptomycin produced. 2. The results suggest that the C-3' branch carbon atom of l-streptose arises from C-3 of d-glucose. 3. The mechanism of biosynthesis of streptose from glucose is discussed. It probably involves an intramolecular rearrangement of a 6-deoxy-4-oxyhexose derivative, and it is suggested that the nucleoside diphosphate sugar derivative hitherto recognized as an intermediate in the biosynthesis of l-rhamnose might participate in such a rearrangement.


Studies on the metabolism of the protozoa. The molecular structure of a starch-type polysaccharide from Polytoma uvella. 1. Polytoma uvella, when grown in an acetate-containing medium, synthesizes a starch-type polysaccharide. 2. The starch differs from normal plant starches in having a lower iodine affinity, and in being relatively insoluble; this latter property makes fractionation difficult. 3. The starch contains about 16% of amylose, and on fractionation yields a branched amylopectin component that is similar in structure to a typical plant starch amylopectin.


Biosynthesis of pulcherriminic acid.

Biosynthesis of pulcherriminic acid. 1. Candida pulcherrima was grown on a complex medium to which various compounds had been added to determine their effect on the biosynthesis of pulcherriminic acid. Most of the pulcherriminic acid synthesized by C. pulcherrima PRL2019 was derived from the l-[1-(14)C]leucine added to the medium. 2. The cyclic dipeptide of l-leucine (cyclo-l-leucyl-l-leucyl) was shown, by trapping experiments involving cycloleucyl-leucyl isomers, to be synthesized by strain PRL2019. Cyclo-l-leucyl-l-leucyl was derived from l-leucine and was converted into pulcherriminic acid. Cyclo-l-leucyl-l-leucyl was a precursor of pulcherriminic acid in strain PRL2007 also. 3. The results supported the hypothesis that pulcherriminic acid is derived from l-leucine and that cyclo-l-leucyl-l-leucyl is an intermediate in the biosynthesis.


The role of vitamin B12 in the metabolism of Euglena gracilis var. bacillaris. 1. The concentrations of RNA, DNA and protein are decreased in cells of Euglena gracilis var. bacillaris grown on suboptimum concentrations of vitamin B(12). 2. The addition of vitamin B(12) to deficient cells stimulates the incorporation of [(14)C]formate into the above cell components as well as into thymine of DNA and serine and methionine of protein. 3. In a cell-free system from vitamin B(12)-deficient cells, the incorporation of labelled formate into thymidylate is decreased to a greater extent with uridine than with deoxyuridine as the substrate. 4. The addition of unlabelled glutamate dilutes the radioactivity incorporated into thymine from labelled formate. 5. These results are interpreted to mean that, in DNA synthesis, vitamin B(12) has a greater role in the reduction of ribotides to deoxyribotides than in the reduction of formate to thymine methyl and that the vitamin B(12)-dependent conversion of glutamate into beta-methylaspartate also contributes to thymine synthesis.


Arrangement of chromosomes in human cells. I. Associations in metaphase figures.


Delayed hypersensitivity in a state of acquired immunological tolerance.


O-Oxalylhomoserine, a new homoserine derivative in young pods of Lathyrus sativus.


Sugars and amino acids in Brucella and some other Parvobacteriaceae.


Incorporation of 32P-labelled DNA by some strains of group H streptococci in the presence of albumin or the transformation-provoking factor.


Investigations on the mobility of the bottom fauna in the lakes Taltowisko, Mikolajskie and Sniardwy.


A new species of the genus Andricus Hartig (Hymenoptera, Cynipidae) from Poland.


Dinema italicum n. sp. and Dinema parvum n. sp. (Euglenoidina) parasites of copepod eggs from a water body near Rome (Italy).


Effects of cerebellectomy on cortical action potentials evoked by stimulation of muscular nerves in cat.


Basic bile acids. V. On the syntheses and properties of basic bile acids and their derivatives.


Metal complexes of amino acids. I. The circular dichroism of copper(II) complexes with optically active amino acids.


A new method for the synthesis of isoflavones.


Studies of pentazocine (WIN-20228). I. Evaluation as an analgesic in post-operative patients.


Hepatic circulation and hepatic function during anaesthesia and surgery. II. The effect of various anaesthetic agents.


Tracheostomy and its management.

Tracheostomy and its management.


Clinical experiences with a combination of fentanyl and droperidol.


A clinical and economic comparison of  halothane and methoxyflurane anaesthesia.


Neuroleptanalgesics. 3. Effect of innovar-nitrous oxide anaesthesia on blood levels of histamine, serotonin, epinephrine, and norepinephrine, and on urine excretion.


Oral neomycin and respiratory failure.

Oral neomycin and respiratory failure.


Therapeutic availability of antibiotics in parenteral solutions.


Panel discussion: air supply and cross contamination.


Extemporaneous mixing of injectables by physicians and pharmacists.


Electrical fire in the operating room: protective role of the isolated ungrounded circuit.


Determination of 3-methoxy-4-hydroxymandelic acid (VMA) in urine by thin-layer chromatography.


Determination of total iodine in urine, stool, diets, and tissue.


Fluorometric measurement of creatine kinase activity.


An automated technic for the assessment of thyroid status, based upon the binding of I-131-triiodothyronine by serum.


Simultaneous determination of sodium, potassium, chloride, urea nitrogen, and glucose from capillary blood.


The effect of cardiac hyperfunction on its automaticity and reactivity to the chronotropic effect of the vagus.


The clinical significance of the P-sinistrocardiale in left ventricular myocardial infarctions.


The angiological picture of the circulus exorenalis.


Psychiatry at Guy's Hospital. II.

Psychiatry at Guy's Hospital. II.


Child psychiatry looks ahead.

Child psychiatry looks ahead.


Community care of the mentally ill with a note of progress in North Hertfordshire.


Psychosomatic implications of obsessive-compulsive disorders and their resemblance to certain types of central pain.


Electronarcosis at Guy's.

Electronarcosis at Guy's.


Hysterical contracture complicating hemiplegia in a patient with systemic lupus erythematosus, activated in pregnancy.


Insommia in psychiatric patients.

Insommia in psychiatric patients.


Munchausen at Guy's.

Munchausen at Guy's.


Psycho-genesis in the "stiff-man syndrome".


Psychiatric referral of medical and surgical out-patients.


Changes in some body electrolytes during recovery from depression.


The management of a disturbed patient in a general ward.


The way back--rehabilitation.

The way back--rehabilitation.


A case of severe psychogenic pain.

A case of severe psychogenic pain.


A monosymptomatic phobia relieved by behaviour therapy.


Problems of psycho-sexual orientation.

Problems of psycho-sexual orientation.


Genetic polymorphism in caseins of cow's milk. VI. Amino acid composition of alpha-s-1-caseins A, B, and C.


Interaction of buffalo's milk and casein with chlorine and bromine in aqueous solutions.


Transfer of radiostrontium from cows' feed to milk.


Factors influencing milk fat depression on rations high in concentrates.


Effects of dry matter in low-moisture silage on preservation, acceptability, and feeding value for dairy cows.


Ration effects on rumen acids, ketogenesis, and milk composition. II. Restricted roughage feeding.


Some blood constituents of dairy cattle: influence of thyroxine and high environmental temperature.


Metabolism of acetate, propionate, and n-butyrate in young milk-fed calves.


Iodine-131 retention in calves.

Iodine-131 retention in calves.


Factors affecting zinc content bovine hair.


Heptachlor persistence in the alfalfa-production environment.


Simple method for analysis of the fatty acid composition of milk fats.


Apparent immunological similarity of bovine beta-lactoglobulins A, B, and C.


Oxytetracycline-binding properties of Streptococcus lactis.


Effect of feeding thiocyanate to dairy cows on absorption and clearance of intramammary iodine.


Pyruvate metabolism in the dairy calf.

Pyruvate metabolism in the dairy calf.


Blood loss and replacement in plasmodial infections. VI. Plasmodium berghei in splenectomized rats.


Is it El Tor vibrio in Calcutta?

Is it El Tor vibrio in Calcutta?


Studies on the immunodiagnosis of schistosomiasis. I. Intradermal skin tests with fractionated antigens.