Graduate program in biomedical communication. The need for harnessing the achievements of communication technology to the burgeoning mass of biomedical information is critical. Recognizing this problem and aware of the short supply of professionals with the skills necessary for the job, a group of leaders from the fields of medicine and communications formed a consortium in 1967 and have developed a twelve month graduate program in biomedical communication. Designed to ground the advanced student in the development and administration of biomedical communication programs, the curriculum focuses on the principles and practice of communication and the development of communications media. Courses are given in the control and communication of information; the printed and spoken word; visual media of photographic arts, television, and motion pictures; computer science; and administration and systems analysis.


The role of the medical librarian in SDI systems. Many ongoing selective dissemination systems designers assume that the librarian can be omitted from active participation in execution of the master plan. ISI's four years of experience with ASCA(R) service have shown that librarians must be an integral part of the system and engage in an active dialogue between users and the machine. Specific examples of how librarians can best serve the information needs of scientists using SDI systems are examined. It is the basic contention of this paper that the librarian should serve as an intermediary between users and the numerous new information media. In this manner the librarian can filter and translate the requirements of individual scientists to conform with the inherent limitations of all machine systems while exploiting their capabilities to the fullest.


The library committee in the medical school. The value of the library committee, commission, or council has been debated by librarians in various types of libraries. A questionnaire of forty-one questions was sent to 109 medical and osteopathic school librarians. Ninety-nine respondents answered pertinent questions. These questions attempted to ascertain the actual functions and accomplishments of the faculty library committee. Librarians were encouraged to express their views on how well the committee fulfilled its functions and whether they thought the committee to be an asset. Although this study is based on the experience of medical school librarians, the literature on the library committee in university, college, public, school, special, and medical school libraries is reviewed.


Trends in nursing education and the school of nursing librarian. The history of nursing education in America is briefly told, with the growth of education in institutions of higher learning emphasized. Two trends in nursing education are paralleled by similar developments in nursing literature. The growth of scholarship in nursing is also noted. It is pointed out that nursing is a discipline in its own right, and that training for leadership is required. Continuing education programs are mentioned, together with the increase in nursing literature. Integrated libraries for the health sciences are recommended.


Planning new medical library buildings: an annotated checklist with selected references. Special attention is paid to several planning essentials for new medical library buildings. These should be covered in the program of requirements that appears as item six on the checklist. The checklist assumes that the decision to build a new medical library has been made and that monies have been allocated for that purpose. References pertaining to the checklist items are provided along with a suggested timetable for achieving each, based on the author's own experiences.


New medical library buildings. I. The Milton S. Hershey Medical Center Library of the Pennsylvania State University. This paper discusses a new medical library. The physical plant, the development of the collection, and special activities are described. The budget is presented.


Biomedical communication.

Biomedical communication.


Esophageal atresia and tracheo-esophageal fistula. 25 years' experience and current management. A review of the experience with esophageal atresia and tracheoesophageal fistula over a 25-year period appears to lead to the advisability of the following procedures in surgical management:* Emergency gastrostomy under local anesthesia in all patients.* Extrapleural interruption of tracheo-esophageal fistula and end-to-end esophago-esophagostomy in patients who have the common type of upper esophageal atresia with distal tracheo-esophageal fistula.* Upper esophageal stretching and eventual esophago-esophagostomy in patients with proximal and distal esophageal atresia with or without proximal tracheo-esophageal fistula.


The potentially suicidal patient.

The potentially suicidal patient.


Atrial myxoma.

Atrial myxoma. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California Medical Center, San Francisco. Taken from transcriptions, they are prepared by Drs. Martin J. Cline and Hibbard E. Williams, Associate Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.


The health of the nation's health care system.


Dementia. Current concepts.

Dementia. Current concepts.


Preventive medicine--present and future.


Aspirin and salicylic acid, et al.

Aspirin and salicylic acid, et al.


Disseminated intravascular coagulation: new bottles for an old wine.


Aids to cardiac diagnosis from examination of the cervical veins.


Chloramphenicol--another warning.

Chloramphenicol--another warning.


Gastrojejunal mucosal prolapse after subtotal gastrectomy.


Selection, training and indoctrination of hospital industrial engineers.


Is the pediatric nurse becoming extinct?


Leasing: a way out. A budgetary tool.

Leasing: a way out. A budgetary tool.


Central purchasing program for drugs.

Central purchasing program for drugs.


Economy and efficiency--the service component of CSR.


Disposables--new wrinkles.

Disposables--new wrinkles.


The computer and total medical information processing--a present fiction.


On a possible mode of action of the gonadotrophin-inhibiting factor (GIF) of human male urine.


The effect of temperature on the responses to electrical stimulation of the isolated cerebral cortex of the cat.


The effect of moderate exercise on the regional distribution of blood flow in the rat.


The medial forebrain bundle (MFB) and ascending monoaminergic pathways in the cat.


Blood flow in different areas of the gastrointestinal tract in the anesthetized dog.


Effects of Mn++ on 45Ca content and potassium-induced contraction of the aortic strip.


Evidence for a renal-dependent factor in the control of muramidase (lysozyme) formation.


The effect of physical training in manifest ischemic heart disease.


he effect of acute digitalization on the hemodynamic response to exercise in coronary artery disease.


Prodromatan acute myocardial infarction.


Hemodynamic responses to oxygen breathing in children with severe anemia.


Urinary catecholamine excretion in myocardial infarction.


Cardiovascular pharmacology of propranolol in man.


Studies in human atrial flutter with the use of proximity electrodes.


His bundle rhythm.

His bundle rhythm.


Long-term pervenous atrial pacing.

Long-term pervenous atrial pacing.


Left atrial transport in mitral stenosis.


Plasma renin activity in end-stage kidney disease.


Primary pulmonary hypertension in a child. Response to pharmacologic agents.


Hepatic injury caused by L-alpha-methyldopa.


Cryosurgical treatment of tumors.

Cryosurgical treatment of tumors.


Analysis of 830 cases of rectal adenocarcinoma. 1. Progressively improved results of treatment.


Post-vagotomy ECG abnormalities.

Post-vagotomy ECG abnormalities.


The nature of pancreatic ascites.

The nature of pancreatic ascites.


The axon reflex in Helix pomatia.

The axon reflex in Helix pomatia.


The capsular barrier between the interstitial fluid and the source of the lymph.


Irradiation of differentiating mouse oocytes.


Studies with liquid membranes: association of some metal ions with phospholipids.


Cerebellum and cerebrum model with periodic processing, neurotubules conduction hypothesis.


Relations and extent of the zone of intensified protein metabolism in the liver acinus.


On the possible role of crystals in the origins of life. II. The adsorption of amino acids by apatite crystals.


On the physiology of dendrites.

On the physiology of dendrites.


Conformational flexibility of proteins, their resistance to proteinases and temperature conditions of life.


Human chromosome analysis as computed from arm lengths measurements.


Chromosomal aberrations in cultured leukocytes from pigs derived from X-irradiated semen.


Cytogenetic and endocrine studies of a freemartin heifer and its bull co-twin.


Placental chorangiomata and mental deficiency in a child with 2/15 translocation: 46,XX,t(2q-;15q+).


Acetylcholinesterase activity in certain areas of the rabbit brain following the unilateral excision of the optic nerve.


Some oxidative enzymes in Fasciola hepatica L. and Dendrocoelum lacteum Müll. 3. Parenchyma and excretory system.


The effect of gonad removal and administration of oestrogen to gonad-deprived rats on the thyroid glan Cytological and cytochemical studies.


Histological manifestations of the contact sensitivity to oxazolone in the mouse. I. The general characteristics of the response.


Studies on aureofungin as seed treatment in controlling seed borne fungal diseases.


Comparison of the behaviour of nucleic acids in the liver cells of mice treated with large doses of various steroid compounds.


Antibiotics in plant disease control. I. Relative efficacy of antibiotics for the control of covered smut of oats (Ustilago hordei (Pers.) Lagerh).


Control of Alternaria blight and powdery mildew of cumin (ZEERA).


Effect of seed treatment with fungicides and antibiotic aureofungin on the efficacy of nodulation by Rhizobium strain of groundnut.


Efficacy of antibiotics and fungicides against corn stalk rot bacteria.


Aureofungin spray in the control of leaf rust of wheat.


Outbreak of black rot of cabbage (Xanthomonas campestris) in Udaipur, Rajasthan and effect of antibiotics on the growth of the pathogen in vitro.


In vitro activity of three antifungal antibiotics against Protomyces macrosporus, Taphrina maculans and Corticium sasakii.


Impact of adolescent patients on a psychiatric hospital.


Training child-care specialists.

Training child-care specialists.


Furnishing a psychiatric unit for children.


A nursery school for day patients' children.


Mexico's combined social and health programs.


Modification of a vintage ward cottage.

Modification of a vintage ward cottage.


Participation training: an instrument for milieu change.


A device for preventing dental injuries during ECT.


A survey of community helpers.

A survey of community helpers.


Contamination or sanitation?

Contamination or sanitation?


A bacteriological study of liquid nourishment in hospitals.


Cross-contamination in food handling and acute salmonella gastroenteritis in the hospital.


Prescription for malpractice.

Prescription for malpractice.


Patient safety versus medical training.

Patient safety versus medical training.


Guidelines for administration of intravenous additives by nurses on the intravenous therapy team.


A review of pharmacy for nurses.

A review of pharmacy for nurses.


Feeding the child is a nursing team function.


The problem of pickup and delivery.

The problem of pickup and delivery.


Equipment fair.

Equipment fair.


Flexible attitudes toward unionization can avert strikes.


Ten management development principles.

Ten management development principles.


An alcoholic treatment center in a community general hospital.


Recognizing economic indicators.

Recognizing economic indicators.


New Lourdes Hospital to have conveyor and tube system.


New design enhances nursing efficiency.

New design enhances nursing efficiency.


Food waste disposers and contamination.

Food waste disposers and contamination.


Mathematical basis for computer-planned nonselective menus.


A meal pattern system coordinated for different institutions.


Death and transplantation.

Death and transplantation.


Four views of organ transplants. Physician sees difficulty in establishing goals for clinical efforts.


Four views of organ transplants. Administrator cites questions that must be resolved before transplantation can be accepted as practical therapy.


Four views of organ transplants. Clergyman says "moral problems" stem from emotion, not ethics.


Four views of organ transplants. Attorney describes current efforts to establish uniform guidelines.


Rural planning.

Rural planning.


Urban planning.

Urban planning.


Co-op EDP.

Co-op EDP.


The peripheral corridor plan.

The peripheral corridor plan.


Disposing of disposables.

Disposing of disposables.


Microbiological contamination control in hospitals. 2. Role of the engineer.


Needed: better pharmacy service. 1. The need in the small hospital.


Camille revisited. A critique of community response to a major disaster.


Evolution of amoebic lesions.

Evolution of amoebic lesions.


Effect of pH and serum percentage in the medium on the growth of sheep kidney cells in tissue culture.


Aneurysm of fossa ovalis.

Aneurysm of fossa ovalis.


Salmonella enteritidis isolated from a focus of chronic osteomyelitis in a fatal case of agranulocytosis.


Head dimensions of Punjabi boys and girls aged 6-15 years.


Breath-holding attacks. The role of psychological factors and iron therapy.


The influence of maternal factors on birth-weight of the newborn.


Fanconi's anemia. Report of 3 cases.

Fanconi's anemia. Report of 3 cases.


Cerebellar disorders in childhood. A review.


Accidents as a public health problem.

Accidents as a public health problem.


Health insurance in urban India; a preliminary study.


A study of rural accidents in Pondicherry, South India.


Survey of reportable industrial accidents for one year in Easter Rly. Workshop at Liluah, Calcutta (West Bengal).


Acceptance of sanitary composting in rural areas.


Present-day health organization in Sikkim.


Family planning as perceived by a medical social worker.


Body build (somatotype) distinctiveness in obese women.


Obesity and respiratory stress.

Obesity and respiratory stress.


Relative accuracy of visual assessment of juvenile obesity.


Interaction of dietetics and nutriton with dentistry.


Flavor preferences for formula diets.

Flavor preferences for formula diets.


Legislation--making pharmacy heard.

Legislation--making pharmacy heard.


A model of a centralized tray assembly conveyor system for a hospital.


Poison prevention week activities.

Poison prevention week activities.


Philatelic recognition?

Philatelic recognition?


An experimental analysis...the pharmacist as a drug advisor.


The community pharmacist views himself.

The community pharmacist views himself.


Voluntary or compulsory...continuing education.


Erie county pharmaceutical association...internship program.


Practice continuity and longevity of...women pharmacists.


A practical method of...semi-automating a community pharmacy.


Recruiting minority students.

Recruiting minority students.


Some modifications to Dawson's continuous cyclone column culture apparatus.


The performance of a stable version of Baird-Parker's medium for isolating Staphylococcus aureus.


Microbial flora of raw and pasteurized eff albumen.


Gravimetrical and mycological investigations of soil suspensions in the soil dilution plate technique.


A soil perfusion apparatus.

A soil perfusion apparatus.


The ecology of serotype 4B of Bacillus thuringiensis.


An electron microscope study of the structure of Sericesthis iridescent virus.


Structure of nine arboviruses.

Structure of nine arboviruses.


The effect of protease treatment on the morphology of influenza A, B and C viruses.


A receptor for a Proteus vulgaris bacteriocin.


From the files of the committee for the study of maternal mortality.


A report of the third annual Kentucky camp for diabetic children.


Deaths in a small community hospital.

Deaths in a small community hospital.


Subarachnoid hemorrhage: a physician's guide to diagnosis and treatment.


Presidential address.

Presidential address.


Argininosuccinic aciduria: clinical, biochemical, anatomical and neuropathological observations.


Mental deficiency and malformations in a boy with a group-C ring chromosome: 46, XY, Cr.


Tryptophan loading in tuberous sclerosis.


Induction of labour with prostaglandin F2a.


The effect of prostaglandins on the human pregnant uterus. Observations were made in 15 patients in late pregnancy (36-42 weeks) and in 5 in early pregnancy in order to study the effects of intravenous infusion of pure prostaglandins on the mobility of the human pregnant uterus.  Uterine contractibility was recorded by means of the Oxford Tocograph.  Using both the E prostaglandins and those of the F series, stimulation of myometrial contractility was observed.  The oxytocic properties of the E prostaglandins were particularly marked and reliable. In late pregnancy, and at term, the response was characterized by an increase in both the frequency and amplitude of contractions, without -- in the dosage used -- any appreciable increase in tone.  Hypertonus was a feature of the response during the early months of pregnancy.  Slow in action, the induced level of uterine activity tended to persist or recur for long after the infusion was discontinued and, particularly in the case of prostaglandin E2, was often followed by the successful induction of labor.  On the basis of this study, it appears that the effect of prostaglandins in bringing about termination of pregnancy may be indirect.


The role of amnioscopy in the prevention of antepartum hypoxia of the fetus.


The antenatal diagnosis oplacental calcification.


Douglas AS: The behaviour of the coagulation and fibrinolytic mechanisms in abruptio placentae.


Moulding of the pelvic outlet.

Moulding of the pelvic outlet.


Primary invasive carcinoma of the vulva in Jamaica.


Variations in physical signs in pubertal girls.


Vacuum aspiration in the treatment of incomplete abortion.


Two pregnancies following subtotal adrenalectomy for Cushing's syndrome caused by bilateral nodular hyperplasia of the adrenal cortex.


The C.O. Sappington Memorial Lecture 1969. The role of occupational medicine in modern society.


The biological warfare problem.

The biological warfare problem.


Uterine fibromyomata and secondary polycythaemia.


Long-term mortality study of steelworkers. 3. Follow-up.


Socio-economic level and mental health.

Socio-economic level and mental health.


Longevity of diabetics.

Longevity of diabetics.


Nitrogen dioxide inhalation and bronchiolitis obliterans. A review of the literature and report of a case.


Committee on Evaluation.

Committee on Evaluation.


Comment on confidentiality of medical records.


Unions and occupational health.

Unions and occupational health.


The narcotic withdrawal syndrome in the newborn infant.


Non-surgical treatment of temporomandibular joint arthrosis.


Shock from hidden hemorrhage.

Shock from hidden hemorrhage.


Congenital glaucoma.

Congenital glaucoma.


Geoaphic and secular variation n mortality from malignant disease in Oklahoma 1956-1965.


Generalized resistance to the effects of psychological stressors.


American Burn Association Medals.

American Burn Association Medals.


Bacteria, carbon dioxide, and algal blooms.


Standards for surgical implants.

Standards for surgical implants.


Vertebrectomy and fusion for "tear drop fracture" of the cervical spine: case report.


Nitrogen contamination of groundwater by barnyard leachates.


The separation, structure and metabolism of monogalactosyl diglyceride species in Chlorella vulgaris.


Dihydrosterculic acid, a major fatty acid component of Euphoria longana seed oil.


Flotation rates, molecular weights and hydrated densities of the low-density lipoproteins.


The effect of dietary copper on the structure and physical properties of adipose tissue triglycerides in pigs.


The role of lipids in membrane transport in Mycoplasma laidlawii.


Neutral lipid and fatty acid composition of earthworms (Lumbricus terrestris).


Microbial hydration of cis-9-alkenoic acids.


Cholesterol content of human parotid saliva.


Steroids in bovine muscle and adipose tissue.


Variation in plasma lipids with age and sex in a hypertriglyceridemic rat.


Methyl octadecadienoates as protectors against inactivation of alkaline phosphatase by gamma-radiation.


Regulation of hepatic carbohydrate metabolism by FFA and acetyl-CoA: sequential feedback inhibition.


X-ray opacification of hepatic lymph nodes following intravenous injection of tantalum dust.


The education of nurses in N.S.W.

The education of nurses in N.S.W.


The lymphatic system of the heart.

The lymphatic system of the heart.


Alcohol and traffic injury.

Alcohol and traffic injury.


Safety code for night clothes.

Safety code for night clothes.


The cost of medical books.

The cost of medical books.


Mini-exchange and transfusion therapy for drug-induced thrombocytopenia.


Disodium cromoglycate ("Intal") in the treatment of asthma.


Human infections with mouse favus in a rural area of South Australia.


The detection and significance of small degrees of hypercalcaemia.


An assessment of body-weight traction on a polished inclined plane in the treatment of discogenic sciatica.


A comparison of an acridan derivative (Smith Kline and French 14336) and trifluoperazine in the treatment of chronic schizophrenia.


Nasal speech, adenoidectomy and the Hynes' pharyngoplasty.


The first kilogram. 2. The protein content of breast milk on mothers of babies of low birth weight.


A case of puerperal tetanus with recovery.


Iatrogenic disease.

Iatrogenic disease.


Some psychological problems of quadriplegics.


Is a man who is pulseless and has stopped breathing dead?


Serum growth hormone and insulin in females without glucose intolerance.


New lipoprotein differing in charge and density from known plasma lipoproteins.


Plasma triglycerides in genetically obese rats.


Glycine loading test in acute intermittent porphyria patients and their relatives.


Thiazide-induced parathyroid stimulation.


A Research Protocol Review Committee for the state of Michigan.


New approaches must be explored to Medicaid problems.


Chlorpropamide in idiopathic diabetes insipidus.


Cervical cerclage.

Cervical cerclage.


The use of thiorizine in a comprehensive mental health program.


[Clinical experience with a new secretolytic drug].


Inhibiton of protein synthesis in mammalian cells by actinobolin.


Optical studies of drug-protein complexes. 3. Interaction of flufenamic acid and other N-arylanthranilates with serum albumin.


Biphasic decrease of radioactive hemoprotein from liver microsomal carbon monoxide-binding particles. Effect of phenobarbital and chlordane.


At the green grass roots.

At the green grass roots.


Nucleic acid synthesis in intact nuclei isolated from mouse fibroblasts. Characterization of the system and effects of glucocorticoids.


A patient with suspected Prader-Willi syndrome at a mental subnormality hospital. 1.


Substitution of kidney function by artificial means. 2. Dialysis therapy and peritoneal dialysis.


Central sterile supply--costing.

Central sterile supply--costing.


Management of mental confusion in the aged.


School out of stables. St. Mary's Hospital, Paddington.


The nurse in general practice and the widening scope of her surgical role.


Substitution of kidney function by artificial means. 4. Home dialysis.


Calf cyst arising from the knee joint in rheumatoid arthritis.


Salmon in the Isle of Wight.

Salmon in the Isle of Wight.


The diagnosis of deep vein thrombosis by ultrasound.


The Thorns sextuplets. 1. The three who lived: Julie, Susan and Roger.


The Northgate story.

The Northgate story.


Recognition of unwanted drug effects. 1.


Prevention of prolonged labour.

Prevention of prolonged labour.


Salmon and top management. 1. Assessing Salmon schemes.


Dictaphones in health visiting.

Dictaphones in health visiting.


Hepatic coma.

Hepatic coma.


Salmon and top management. 2. The main task of the CNO and the qualities needed for success.


Bilateral Perthe's disease of the hip in a seven year old.


Running a renal unit: some details from Dulwich.


The Thorns sextuplets. 2. The three who died: Lynne, Ian and an unnamed girl.


Recognition of unwanted drug effects. 2.


Characteristics of hospital care.

Characteristics of hospital care.


Cardiological aspects of chest pain.

Cardiological aspects of chest pain.


Arthritic causes of chest pain.

Arthritic causes of chest pain.


Mechanical and postural causes of chest pain.


Duodenography in pancreatic disease with special reference to 'instant duodenography'.


Angiography of pancreas.

Angiography of pancreas.


Pancreatic scanning.

Pancreatic scanning.


Time sequence tomography in arteriography of the pancreas.


The bioassay of androgens and anti-androgens using sebum secretion in the rat.


Hormonal factors influencing the response of the sebaceous gland to androgens.


In vivo antagonism of melanophore-dispersing hormone by melatonin in adult Xenopus laevis.


xomphalos and marcroglossia (Beckwith's syndrome).


Pulmonary candidosis.

Pulmonary candidosis.


Mild hyperparathyroidism in a girl aged 10 years 6 months.


Therapeutic problems of adolescent homocystinuria.


Retinal vein thrombosis with peripheral venous thrombosis and thrombocytopenia.


Cerebral emboli from aneurysm of left atrial appendage.


Psychosis in systemic lupus erythematosus (SLE) and the response to cyclophosphamide.


The relationship between anatomical site of injury and particular sports.


Prevention of sports injury.

Prevention of sports injury.


Medical criteria in the selection of athletes.


Late effects of neglected soft tissue injury.


Stress fractures in athletes.

Stress fractures in athletes.


Knee injuries in athletes.

Knee injuries in athletes.


A clinic for athletic injuries.

A clinic for athletic injuries.


Management of severe deafness in adults. The psychiatrist's contribution.


Management of severe deafness in adults. The otologist's contribution.


Behavior modification in a workshop.

Behavior modification in a workshop.


Vocational rehabilitation of the disabled resident in rural areas.


Management of severe deafness in adus. The place of electronic amplification.


CO2 washout during hyperventilation in man.


Mechanics of ventilation in the pilot whale.


Pressure-diameter relations of capillaries and small blood vessels in frog lung.


Respiratorresponse to hypoxia with hypocapnia or normocapnia and to CO2 in hythermic dogs.


Alveolar to mixed venous PCO2 difference under conditions of no gas exchange.


Role of the arterial chemoreceptors in controlling lung volume in the dog.


Influence of calcium and magnesium on the respiratory response to changes in CSF pH.


A low-resistance flow meter for wide-range ventilatory measurement.


Calculating diffusion in biological systems by random walks with special reference to gases diffusion in the lung.


Comparative studies of the respiratory function of mammalian blood. V. Insectivora: shrew, mole and nonhibernating and hibernating hedgehog.


Some respiratory properties of sheep hemoglobins A, B, and C.


Chloride distribution between red blood cells and plasma in the dogfish (Scyliorhinus canicula).


A guide for parents of children receiving special education.


Oxygen equilibria of partially oxidized hemoglobin.


Acid-base changes of arterial plasma during exogenous and endogenous hypercapnia in man.


Direct and rebreathing estimates of the O2 and CO2 pressures in mixed venous blood.


Oxygen consumption of frog tissues under high hydrostatic pressure.


Flow patterns in models of the human bronchial airways.


Ventilatory responses to peripheral nerve stimulation at different times in the respiratory cycle.


Time delay technique in respiratory instrumentation.


Acrodermatitis enteropathica.

Acrodermatitis enteropathica.


The effect of antibodies anti-polyamine on the growth of sarcoma T.R.V.L. 53886 in mice.


Effects of protein deficiency on implantation and embryogenesis in the rat.


The foetal toxicity of leucine in the rat.


Heights and weights of Bermudian school children of African and European origins.


Intensive therapy--a general appraisal.

Intensive therapy--a general appraisal.


The purpose-built dental practice. A dentist's view.


Problems of human protein nutrition.

Problems of human protein nutrition.


The purpose-built dental practice: an architect's view.


Are allergic conditions a significant cause of school absence?


Wastes and your water supply. Pollution and ecological balance.


Local authority catering with frozen food.


Clinical and cytogenetic observations on four true hermaphrodites.


Innervation by nerve implants of "fast" and "slow" skeletal muscles of the rat.


Effects of topical acetylcholine on secretion and motility in Heidenhain gastric pouches in dogs.


Pulmonary diffusing capacity limiting human performance at altitude.


Metabolism of dopamine and noradrenaline in normal, atrophied and postganglionically sympathectomized rat salivary glands in vitro.


Enzyme activities at the surface of intact human erythrocytes.


Production and distribution of intracranial and intraspinal pressure changes at sudden extradural fluid volume input in rabbits.


"Concussive response" and intracranial pressure changes at sudden extradural fluid volume input in rabbits.


The effect of menthol on taste receptors.


Abortion--repeal of Alaska law?

Abortion--repeal of Alaska law?


Non-uniform blood flow in the left ventricular wall of dogs measured by the Xe-133 wash-out technique.


Isolation of fibrinopeptides formed during intravascular coagulation in dogs.


The role of medicine in the revolution in medicine.


Pyogenic granuloma of the gingiva.

Pyogenic granuloma of the gingiva.


Disseminated intravascular coagulation in a patient with metastatic adenocarcinoma of the rectum.


Mythology of alcohol.

Mythology of alcohol.


The acute alcoholic: medical responsibility.


Letters to the editor: role of the public health nutritionist.


Otitis media in Alaskan Eskimo children: an epidemiologic review with observations on control.


Letters to the editor: protein-calorie malnutrition.


Centers of nutritional excellence: Cornell University, Ithaca, New York.


Reassessment of amino acid requirements of young women on low nitrogen diets. 1. Lysine and tryptophan.


Factors affecting body density and thickness of subcutaneous fat. Data on 518 Canadian city dwellers.


Nephrectomy following liver biopsy.

Nephrectomy following liver biopsy.


The right to be well born: quality versus quantity in obstetrics and gynecology.


Dietary calcium and fat. Effect on serum lipids and fecal excretion of cholesterol and its degradation products in man.


Prophylaxis of tuberculosis after gastrectomy.


Zinc-dependent enzymes in zinc-depleted rats; intestinal alkaline phosphatase.


Early events in the stimulation by zinc of cytochrome c synthesis in Ustilago.


Free amino acids of normal and abnormal human placenta.


Maternal folate deficiency and pregnancy wastage. I. Placental abruption.


Endometrial biopsy inadvertently taken during conception cycle.


Organ culture of human endometrium. Effect of ovarian steroids.


Observations on fetal heart rate and fetal biochemistry. I. Base deficit.


Correlation of estriol excretion patterns of pregnant women with subsequent development of their children.


Integration of undergraduate and graduate education in obstetrics-gynecology. A report by the Committee on Education of the American Gynecological Society.


Community prenatal care: an "integrated" approach.


Effect of fetal metabolic acidosis upon oxygen environment.


Desquamative interstitial pneumonia and idiopathic diffuse pulmonary fibrosis; with their advanced final stages as "muscular cirrhosis of the lung" (diffuse bronchiolectasis with muscular hyperplasia).


Therapeutic abortions in California. First year's experience under new legislation.


Pulmonary histiocytosis X. A review of 18 patients with reports of 6 cases.


Lung scanning in the assessment of respiratory disease in children.


Bronchial and intercostal arteriography in non-neoplastic pulmonary disease.


Selective coronary arteriography by the percutaneous femoral artery approach.


Uneven distribution of pulmonary blood flow between left and right lungs in isolated valvular pulmonary stenosis.


The roentgenologic findings in hypoplastic rit heart complex.


Tc99m pertechnetate angiocardiography in the diagnosis of superior mediastinal masses and pericardial effusions.


Roentgenographic diagnosis of complications in heart valve replacements.


Abnormal vascular communications.

Abnormal vascular communications.


The angiographic features of organizing splenic hematoma (?hamartoma).


Radiographic detection of preclinical and asymptomatic cancer of the lung.


Laboratory and clinical observations on prenatal rubella.


Angiographic evaluation in external arteriovenous shunt management.


Hydrodynamic distortion in the cochlea.

Hydrodynamic distortion in the cochlea.


Edmund P. Fowler Memorial Lecture. Otology in the modern hospital.


Long-term clinical and metabolic effects of vagotomy with either gastrojejunostomy or pyloroplasty.


Diaphragmatic muscle and cardiac surgery.


The inhibition of adjuvant disease in rats by the interferon-inducine agent pyran copolymer.


Mechanism of complement binding by the red cell in rheumatoid arthritis.


Comparative bioassay of drugs in adjuvant-induced arthritis in rats: flufenamic acid, mefenamic acid, and phenylbutazone.


Radioimmunoassay of rheumatoid factor.

Radioimmunoassay of rheumatoid factor.


Experimental corticosteroid myopathy.

Experimental corticosteroid myopathy.


The removal of aggregated and nonaggregated autologous gamma globulin from rheumatoid joints.


Recurrent hemarthrosis after prosthetic knee arthroplasty: identification of metal particles in the synovial fluid.


Serological reactions of the rheumatoid factors.


Cyclophosphamide treatment of rheumatoid arthritis.


Cytoplasmic tubular structures in kidney biopsies in systemic lupus erythematosus.


Experiences with the ossicular chain.

Experiences with the ossicular chain.


Does cycloheximide interfere with protein degradation?


The synthesis of mouse hemoglobin beta-chains in a rabbit reticulocyte cell-free system programmed with mouse reticulocyte 9S RNA.


An approach to the study of the structure of desmosine and isodesmosine containing peptides isolated from the elastase digest of elastin.


Impaired renal acidification in Sjögren's syndrome and related disorders.


Diastereoisomers of uracil glycoside photohydrates.


Myeloperoxidase X: comparison of normal human leucocyte myeloperoxidase prepared with and without the use of trypsin.


Chain pairs in the crosslinking of fibrin.


Redistribution of the electrical charge of the mitochondrial membrane during energy conservation.


A chromatographically different form of the formyl-accepting methionine transfer RNA from Escherichia coli.


On the use of bromthymol blue as an indicator of internal pH changes in chromatophores from Rhodospirillum rubrum.


Evidence against the obligatory formation of an acyl enzyme intermediate in the alpha-chymotrypsin catalyzed reactions of amides.


Affinity chromatography of a regulatory enzyme based on specific interaction with the effector.


Formation of acetylglypuromycin by the incubation of hen's oviduct minces with puromycin.


Thermolysin: a zinc metalloenzyme.

Thermolysin: a zinc metalloenzyme.


Extrinsic properties of optical activity in adrenal iron-sulfur protein (adrenodoxin).


Aryl hydrocarbon hydroxylase activity in human placenta from cigarette smoking and nonsmoking women.


The effect of croton oil pretreatment on skin tumor initiation in mice.


Fine structure of murine pulmonary adenomata induced by carcinogen treatment in organ culture.


Cytotoxic effects of 1-beta-D-arabinofuranosyl-5-fluorocytosine and of 1-beta-D-arabinofuranosylcytosine in proliferating tissues in mice.


Persistent binding of 2-acetylaminofluorene to rat liver DNA in vivo and consideration of the mechanism of binding of N-hydroxy-2-acetylaminofluorene to rat liver nucleic acids.


Further evidence of common antigenic properties in chemically induced sarcomas of mice.


Protection of cultured hamster embryonic cells from 7,12-dimethylbenz(a)anthracene cytotoxicity and the induced synthesis of aryl hydroxylase.


Morphologic and serologic studies of transplanted human leukocyte culture (M-1) cells in laboratory animals.


An electron microscopic examination of murine plasma cell neoplasms with and without paraproteinemia.


The effects of 5-iodo-2'-deoxyuridine upon the replication of ileal and spleen cells in vivo.


Electron microscopic studies on HeLa cells exposed to the antibiotic toyocamycin.


Reduction in the frequency of mutation to resistance to cytarabine in L1210 murine leukemic cells by treatment with quinacrine hydrochloride.


Pediatric nurse-practitioners and screening physical examinations.


Office electrocardiography in general pediatrics. IV. Arrhythmias--premature beats and fast heart rates.


Rheumatoid arthritis versus lupus erythematosus in a child.


"Why Johnny's parents don't read." An analysis of indigent parents' comprehension of health education materials.


Management of cardiac and respiratory arrest in children. A survey of major principles of therapy.


Recessive sex-linked mental retardation in the absence of other recognizable abnormalities. Report of a family.


Prevention and treatment of post-gastrectomy disorders.


Halitosis and its management.

Halitosis and its management.


Man-computer interaction--the contribution of the human sciences.


Man-computer interaction: a challenge for human factors research.


The use of multi-man system trainers.

The use of multi-man system trainers.


Aiding the decision maker--a decision process model.


Display design: principles and procedures.


Archetypes in man-computer problem solving.


Developments in selection and training.

Developments in selection and training.


On adaptive manual control.

On adaptive manual control.


Theory of manual vehicular control.

Theory of manual vehicular control.


Bias in experimental comparisons between equipments due to the order of testing.


Further studies on the metabolism of tartrazine and related compounds in the intact rat.


Formation of N-nitrosamines from secondary amines and nitrite in human and animal gastric juice.


The pharmacokinetics of HEOD (Dieldrin) in the rat.


Short-term feeding study of sodium ferrocyanide in rats.


beta-Glucuronidase activity in the urine, serum, kidney and bladder of rats fed 2-chloro-4-nitrobenzamide, 3,5-dinitrobenzamide or 3,5-dinitro-o-toluamide.


The effects of positive and negative reinforcement and test anxiety on the reading performance of male elementary school children.


Task and motivational influences on the assessment of creative and intellective ability in children.


Reduced gravity simulaon.

Reduced gravity simulaon.


Reduced-gravity simulators for studies of man's mobility in space and on the moon.


Work in reduced-gravity environments.

Work in reduced-gravity environments.


Prototype of a new lunar-gravity simulator for astronaumobility studies.


Lunar simulation.

Lunar simulation.


Behavior modification: a therapeutic milieu for chronic schizophrenics.


Childhood bronchial asthma in Hawaii.

Childhood bronchial asthma in Hawaii.


Serum protein patterns in acute myocardial infarction.


Reduced-gravity human factors research with aircraft.


Force application in simulatd zero gravity.


Water immersion reduced-gravity simulation.


Lower urinary tract metastasis from clear cell carcinoma of the kidney. A case report.


Carcinoma of the prostate presenting as an epigastric lump.


Lymphadenography in malignant disease involving lymph nodes.


Intralymphatic chemotherapy--case report of a successful result.


Cytological study of induced tumours in rat.


Tumours of the salivary glands.

Tumours of the salivary glands.


Studies in myocardial revascularization.


Studies on wound healing. II. Role of suture materials in healing of skin wounds.


Studies on wound healing. 3. Effect of ascorbic acid and methionine in wound healing.


Succinic dehydrogenase, histidase and acid phosphatase activities of liver homogenates of rats infected with Mycobacterium leprae murium.


Incidence of coronary artery disease in Delhi from medico-legal autopsies.


Effect of different extracts of kutaki (Picrorhiza kurroa) on experimentally induced abnormalities in the liver.


Chemoprophylaxis and chemotherapy in variola major. II. Therapeutic assessment of CG 662 and Marboran in treatment of variola major in man.


An epidemiological study of filariasis in the villages of the Rural Health Training Centre, Sarojini Nagar, Lucknow.


Chemoprophylaxis and chemotherapy in variola major. I. An assessment of CG 662 and Marboran in prophylaxis of contacts of variola major.


A new inbred strain of mouse C17-Icrc developed for testing weak carcinogens.


Studies on the mode of action of streptomycin on Vibrio cholerae and Vibrio el tor.


Chromatin-positive Klinefelter's syndrome.


A simple qualitative test for deterioration of cycloserine.


Deterioration of cycloserine in the tropics.


Enzyme glucose-6 phosphate dehydrogenase (G6PD) deficiency among Sinhalese in Ceylon as revealed by the methaemoglobin reduction test.


Insulin antibodies in diabetes mellitus.


A note on cases of human brucellosis encountered in the Christian Medical College Hospital, Vellore, since August 1965.


Urinary excretion of carcinogenic tryptophane metabolites in cancer of bladder.


Experimental study of the effects of infusions of isoprenaline sulphate and low molecular weight dextran in haemorrhagic shock in the dog.


Correlation characteristics and dimensionality of speech spetra.


Automatic speaker verification using cepstral measurements.


Ultrasonic observations of coarticulation in the pharynx.


Identification of the "shift"  between vocal registers.


Ultrasonic Doppler monitoring of vocal-fold velocity and displacement.


Laser-induced acoustic transients in the mammalian eye.


Some comments on learning associated with the articulation testing of mistuned single-sideband links.


Alterations in the duration, pitch, and intensity of spoken passages successively heard and repeated several times.


Binaural interaction of transients: interaural intensity asymmetry.


Underwater hearing thresholds in man as a function of water depth.


Thresholds re duration and levels of a continuous or gated masker.


Effect of pulsed masking on selected speech materials.


Continuity in alternately sounded tone and noise signals in a free field.


The effects of pelvic inflammation associated with the IUD. A salpingographic study.


Pituitary irradiation therapy in infertility.


Morphology of ovaries treated with clomiphene citrate.


Intrauterine instillation of chemical cytotoxic agents for tubal sterilization and treatment of functional metrorrhagias.


Depth of sequential auditory information processing.


Contralateral remote masking and the aural reflex.


Masking with continuous and pulsed sinusoids.


A study on ovulation inhibition by quinestrol.


Cochlear hair-cell damage in guinea pigs after exposure to impulse noise.


Fluctuations of N1 amplitude in relation to click-intensity discrimination.


Stimulus level of dichotically presented tones and cat superior olive S-segment cell dcharge.


Signal duration and signal frequency in relation to auditory sesitivity.


Influence of pulsed masking on the threshold for spondees.


Government-industry cost sharing for air pollution control.


Performance characteristics of instrumental methods for monitoring sulfur dioxide. II. Field evaluation.


Photochemical reactivities of paraffinic hydrocarbon-nitrogen oxide mixtures upon addition of propylene or toluene.


Photochemical reactivities of N-butane and other paraffinic hydrocarbons.


Determination of iodine concentration and distribution in rat thyroid follicles by electron-probe microanalysis. The concentration and the distribution of iodine in various sized follicles of rat thyroid glands have been analyzed by electron-probe microanalysis. The results of the iodine analysis were grouped according to uncorrected lumen diameter size. No significant differences in iodine concentration were observed among the various size categories. When the results for all follicles from a given sample were pooled, the standard error of the mean was approximately 4%. Usually 40-50 follicles per animal were analyzed. The concentration of iodine ranged from 0.9 to 2.1% by weight among individual animals. Scanning pictures and step-scan analysis showed the iodine distribution to be quite uniform across the colloid area. Several techniques of sample preparation were used; they produced no significant differences in the iodine concentrations observed. Sodium concentration, also determined in all samples, was found to vary from 2 to 9% by weight. Because of the mobility of the sodium ion, its distribution was greatly affected by the method of sample preparation. The technique that best preserved the natural chemistry of the sample was that of freezing the tissue, sectioning, and then freeze-drying.


Fusiform vesicles in plant cells.

Fusiform vesicles in plant cells.


Mitochondria in anaerobically-grown, lipid-limited brewer's yeast.


Activation in vitro of rat liver polyribosomes. The increase in the incorporation of amino acids into protein in vitro by preparations obtained from protein-fed rats as compared with preparations obtained from carbohydrate-fed rats has been described previously. After molecular sieving through Sephadex G-25 of cell-free preparations, the difference in incorporating activity between the two types of rats was diminished in systems containing ATP, phosphoenolpyruvate, pyruvate kinase, GTP, and a mixture of amino acids. When, after molecular sieving, a mitochondrial (15,000 g) supernatant was incubated for 4 min at 35 degrees C the polysomal pattern of the preparations was unchanged. In the presence of ATP, phosphoenolpyruvate, and pyruvate kinase the polysomal incorporating activity was low and the polysomal pattern was only slightly changed. Addition of GTP increased the activity markedly, and a more pronounced activity was observed when a mixture of amino acids was added as well. As the amino acid incorporation ability increased, monosomes were formed from the polyribosomes. The activity of the polyribosomes was severalfold higher than that of non-Sephadex-treated preparations, indicating an activation of polysomal aggregates which under the usually applied conditions of incubation and prior to molecular sieving show little or insignificant activity. It was possible to activate polyribosomes from carbohydrate-fed and protein-fed rats to almost the same extent.


Studies on the microtubules in heliozoa. V. Factors controlling the organization of microtubules in the Axonemal pattern in Echinosphaerium (Actinosphaerium) nucleofilum. On the assumption that the double-coiled pattern of microtubules in the axoneme of Echinosphaerium might be due to links of two sizes between adjacent microtubules, we disassembled microtubules with low temperature and then carefully analyzed the patterns of microtubules that formed upon the addition of heat (22 degrees C) or heat and D(2)O. Although most of the initial clusters of microtubules that formed could not be interpreted as part of an axoneme, the spacings between these microtubules were the same as that in the axoneme, 70 and 300 A. By model building we were able to show that all clusters that form, including stages in the formation of the axoneme and its 12-fold symmetry, could be explained by links of two sizes (70 and 300 A) and the substructure of the microtubule. We could demonstrate these links with improved staining methods. We suggest that nonaxonemal assemblies of microtubules may be eliminated by the natural selection of the most energetically stable configuration of microtubules, all others undergoing disassembly under equilibrium conditions. Model building further supports this suggestion since the model axoneme possesses more links per tubule than any other cluster found.


Indentation of the pellicle of Tetrahymena at the contractile vacuole pore before systole.


Modified cilia in the gut of the lambellibranch mollusc Tapes watlingi.


A simple model of a steady state differentiating cell system. A simple theoretical model is hypothesized to describe the steady state behavior of a differentiating cell system as exemplified by blood cells. The cell system consists of several morphologically distinguishable cell classes which develop sequentially. Each cell class except the last one is mitotically capable. Mitosis is assumed to be either heteromorphogenic, homomorphogenic, or asymmetric. Some algebraic equations are derived which are conservation equations describing the flux of cells from one class to another. The theoretical considerations have been applied to some experimental observations in humans concerning neutrophil production, particularly in reference to relative cell numbers and mitotic fractions of the myeloblast, promyelocyte, and myelocyte cell classes. These observations are utilized to help determine the values of the parameters which characterize the model. Among these parameters are the generation times of the various cell classes, and the predicted values of the generation times are found to be in excellent agreement with observed grain-count halving times. However, the predicted mitotic times are in disagreement with their observed values.


Chromosome micromanipulation. 3. Spindle fiber tension and the reorientation of mal-oriented chromosomes. Kinetochore reorientation is the critical process ensuring normal chromosome distribution. Reorientation has been studied in living grasshopper spermatocytes, in which bivalents with both chromosomes oriented to the same pole (unipolar orientation) occur but are unstable: sooner or later one chromosome reorients, the stable, bipolar orientation results, and normal anaphase segregation to opposite poles follows. One possible source of stability in bipolar orientations is the normal spindle forces toward opposite poles, which slightly stretch the bivalent. This tension is lacking in unipolar orientations because all the chromosomal spindle fibers and spindle forces are directed toward one pole. The possible role of tension has been tested directly by micromanipulation of bivalents in unipolar orientation to artificially create the missing tension. Without exception, such bivalents never reorient before the tension is released; a total time "under tension" of over 5 hr has been accumulated in experiments on eight bivalents in eight cells. In control experiments these same bivalents reoriented from a unipolar orientation within 16 min, on the average, in the absence of tension. Controlled reorientation and chromosome segregation can be explained from the results of these and related experiments.


Special indications and operative methods in renovascular hypertension.


Click-intensity discrimination with and without a background masking noise.


Effect of portal venous hepatic by-pass on urinary histamine excretion in the rat.


Hemoglobin NYU, a delta chain variant, alpha 2 delta 2 lys. A minor hemoglobin (Hb) component with the electrophoretic properties of the delta-chain variant Hb A(2') was encountered in two unrelated families of Russian-Jewish ancestry. This minor component, designated Hb NYU, was shown to result from the substitution of lysine for asparagine at delta(12). We have confirmed studies of others that hemoglobin A(2') isolated from the hemoglobin of some African subjects, results from the replacement of the normal glycine at delta(16) by arginine. Thus for interpretations of the incidence of delta-chain variants in different populations, electrophoretic data are not sufficient. In members of one of the families in the present study, the visual estimations of normal Hb A(2) and of Hb NYU on starch-gel electrophoretic patterns suggested the presence of delta-thalassemia. In hemolysates of one of the heterozygotes for Hb NYU, hemoglobin A(2) was not demonstrable with starch-gel electrophoretic methods but was readily recovered by column chromatography in approximately the amounts expected for delta-chain heterozygotes.


Regulation of human jejunal glycolytic enzymes by oral folic acid. The effect of oral folic acid on jejunal glycolytic enzyme activity in five fasting obese patients and in three normal male volunteers on a constant 3000 cal diet was studied. The glycolytic enzymes, fructokinase, hexokinase, glucokinase, fructose-1-phosphate aldolase, and fructose diphosphate aldolase, and the disaccharidases, sucrase, maltase, and lactase were measured. In both the fasting patients and the normal volunteers, oral folic acid significantly increased the jejunal glycolytic enzyme activities but had no effect on disaccharidase activity. When oral folic acid was discontinued in the normal volunteers, the glycolytic enzyme activities returned to control values. In the obese patients, refeeding and folic acid caused a further increase in glycolytic enzyme activities above that seen with fasting and folic acid. In contrast to oral folic acid, intramuscular folic acid, oral vitamin B(12), and oral tetracycline had no effect on glycolytic enzyme activities. These studies demonstrate that oral folic acid which is neither a substrate nor a coenzyme of these enzymes, increases human jejunal glycolytic enzyme activity in a specific fashion. This would appear to be an action of oral folic acid which has not been recognized previously.


Albumin to ascites: demonstration of a direct pathway bypassing the systemic circulation. The transport of plasma albumin and newly made albumin into ascitic fluid was studied in eight patients with cirrhosis and ascites. The thoracic duct was cannulated in two patients and lymph collected over a period of 2 hr. Simultaneously albumin-(131)I and carbonate-(14)C were injected intravenously. The albumin-(131)I measured the transfer of plasma albumin into ascites and into thoracic duct lymph. The carbonate-(14)C, by labeling newly formed albumin, permitted the estimation of the transfer of newly formed albumin into plasma, ascites, and lymph. If the newly synthesized albumin entering ascites and thoracic duct lymph is delivered initially into the plasma, then the ratios of the albumin-(14)C and -(131)I in ascites and lymph compared with the content of albumin-(14)C and -(131)I in plasma would be identical. However, if some newly formed albumin is delivered directly into ascites or lymph, the ratio for albumin-(14)C would be higher than that for albumin-(131)I in lymph or ascites. The ratios of both labeled albumins found in ascites or lymph are expressed as per cent of the total plasma pool. In the eight patients studied 4.2-11.7% of the albumin-(14)C in plasma was found in ascites in 2 hr whereas only 0.4-2.2% of plasma albumin-(131)I entered in this same period. In the two patients studied during thoracic duct lymph drainage 6.1 and 13.5% of newly made albumin-(14)C appeared in lymph in 2 hr whereas only 2.8 and 3.8% of plasma albumin-(131)I was found in the lymph. In cirrhosis with ascites some newly formed albumin entered ascites and thoracic duct lymph by a direct pathway from the liver bypassing the systemic circulation.


Thoracic duct drainage in the treatment of portal hypertension and its complications.


Sites of in vivo extraction and interconversion of testosterone and androstenedione in dogs. The interconversion and extraction of testosterone and androstenedione across and within different tissues or areas have been studied by the constant infusion technique. The results were calculated using the (3)H/(14)C ratios and radioactive concentrations of testosterone and androstenedione obtained from afferent and efferent blood and tissues at equilibrium. In each tissue studied, the interconversion between testosterone and androstenedione inside the tissue was significantly higher than the corresponding interconversion across the tissue. The pulmonary contribution to the total interconversion between testosterone and androstenedione was far more important than that of any of the other tissues studied. The hepatic metabolic clearance rates of testosterone and androstenedione were not different from their metabolic clearance rates in the mesenteric area. The extraction of each of these compounds, although not negligible, was lower in the kidney and the femoral bed compared with the extraction in the liver and the mesenteric area. Finally, with the possible exception of the liver, testosterone and androstenedione were more completely metabolized when they originated from the cells than from afferent blood. The evaluation of these different tissue transfer constants provides more precise information concerning the relative importance of different sites in the metabolism of these interconverting hormones.


Tocopherol transport in the rat erythrocyte. The transport of vitamin E (alpha-tocopherol) has been studied in the rat erythrocyte in vivo and in vitro. Uptake and efflux are independent of energy, but sensitive to temperature. Tocopherol is localized to the cell membrane. Rapid exchange takes place between erythrocytes and serum with an hourly fractional tocopherol efflux of 26%. The vitamin is transferred from the erythrocyte to the low density lipoproteins. These experiments indicate that tocopherol, like cholesterol, is a constituent of the erythrocyte membrane which is in dynamic equilibrium with the corresponding plasma compound.


Protection of the myocardium during ischaemic asystole with intracoronary administration of ATP.


Very low density lipoproteins in intestinal lymph: origin, composition, and role in lipid transport in the fasting state. The transport of endogenous lipids in the lipoproteins of mesenteric lymph was studied in fasting rats with mesenteric lymph fistulas. The lymph was found to contain, in addition to chylomicrons (S(f) >400), a significant amount of another, more dense, triglyceride-rich fraction, the very low density lipoproteins (VLDL), which showed a peak S(f) of 102. The VLDL differed from chylomicrons not only in flotation, but also in per cent lipid composition and electrophoretic mobility in agarose gel. The VLDL fraction was found to contain 47% of the triglyceride and 54% of the cholesterol of fasting lymph and, in the fasting state, was the major lipoprotein species present. When cholestyramine resin was administered intraduodenally, or bile flow was acutely diverted from the intestine, it was demonstrated that the lipids in lymph VLDL, like those in chylomicrons, were derived from the intestine and bile. These data indicate that the VLDL in intestinal lymph are not derived from the plasma but are of intestinal origin. Because certain properties of lymph VLDL were similar to those reported for plasma VLDL (per cent lipid composition, flotation coefficient, and continuing entry into plasma in the fasting state), additional comparisons between these fractions were made. Although lymph VLDL moved to the alpha(2) region in agarose gel, when they were mixed with VLDL-free serum immediately before electrophoresis they showed the alpha(2) mobility of rat serum VLDL. Furthermore, immunoelectrophoretic comparison of partially delipidated lymph and serum VLDL revealed that these fractions shared in common their major apoprotein, and possibly others as well. The fatty acid composition of lymph and serum triglycerides, as determined by gas-liquid chromatography, revealed that although they were generally similar, differences existed which most likely reflected the presence in serum of triglycerides of hepatic origin. These experiments demonstrate the importance of intestinal VLDL in the transport of endogenous lipids in mesenteric lymph in the fasting state. The similarities between intestinal lymph VLDL and plasma VLDL suggest that the latter may be derived in part from the former.


Effects of alpha-methyl-tyrosine upon catecholamine levels in arterial tissue and plasma and upon peipheral blood flow measurements in the anesthetized dog.


Impregnation of vascular sutures and grafts with radioactive phosphorus.


Arterial reconstruction below the inguinal ligament.


Effects of weight changes produced by exercise, food restriction, or overeating on body composition. The body weight of rats was reduced by exercise or by restriction of food intake over a period of 18 wk. Body composition was studied to determine if exercise protects against the loss of lean tissue that can occur as a result of a negative caloric balance. Rats weighing 706 +/-14 g were divided into four groups matched for weight. A baseline group was killed at the beginning of the study. An exercising group, fed ad lib., was subjected to a program of swimming. A sedentary, free-eating group was provided with food ad lib. Two sedentary, paired-weight subgroups were calorie restricted so that they lost weight at the same rate as the exercisers. The protein intake of one paired-weight subgroup was matched with that of the exercising group. The other sedentary, paired-weight animals ate the standard diet. There was no significant difference in body composition between the two sedentary, paired-weight subgroups which were, therefore, pooled for comparison with the other groups. The exercisers lost 182+/-19 g as a result of both an increase in caloric expenditure and a decrease in appetite. The sedentary, food-restricted animals lost an average of 182+/-18 g. The sedentary, free-eating animals gained 118+/-13 g. The carcasses of the exercised animals contained significantly less fat and more lean tissue than those of the sedentary, paired-weight animals, providing evidence for a fat mobilizing and protein conserving effect of exercise. The composition of the body substance lost by the exercising animals was 78% fat, 5% protein, 1% minerals, and 16% water, compared to 62% fat, 11% protein, 1% minerals, and 26% water for the sedentary, food-restricted rats. Fat accounted for 87% and water for 10% of the weight gained by the sedentary, free-eating animals.


Abdominal aortic aneurysm and unexpected horseshoe kidney.


Traumatic carotid-jugular fistula of long duration surgical treatment.


A new surgical treatment for lymphatic and venous edema.


An unusual complication of obturator foramen arterial bypass.


Studies on the pressor substances of the caudal neurosecretory system of teleost fish: bioassay and fractionation.


The influence of the pineal gland on nitrogen metabolism.


Tissue iodoprotein formation during the peripheral metabolism of the thyroid hormones. The formation of tissue iodoproteins during the peripheral metabolism of the thyroid hormones was examined by determining the concentration of nonethanol-extractable (125)I (NE(125)I) in various tissues after the intravenous injection of 3,5,3'-triiodo-L-thyronine (T3-(125)I) and L-thyroxine-(125)I (T4-(125)I) in groups of rats with iodide-blocked thyroid glands. 3 days after T3-(125)I and 7 days after T4-(125)I injection the concentration of NE(125)I in the liver and kidney was 5-10 times greater than in plasma. Smaller but nonetheless significant concentrations of NE(125)I were demonstrated in skeletal and cardiac muscle. Hepatic subcellular fractionation studies revealed that the major portion of the liver NE(125)I was in the microsomal fraction. Lower concentrations of NE(125)I were present in the nuclear, mitochondrial, and soluble fractions. When similar studies were performed in groups of rats pretreated with phenobarbital, an increase in the metabolic clearance of T3-(125)I (30%) and T4-(125)I (100%) was observed along with a highly significant increase in the NE(125)I concentration of the liver and plasma. The increase in hepatic NE(125)I in these studies was primarily due to the microsomal component. Incubation of hepatic microsomes with T3-(125)I and T4-(125)I showed that NEI formation as well as deiodination appeared to obey simple Michaelis-Menten kinetics. Moreover, the maximal rate of both deiodination and NEI formation was increased when microsomes harvested from phenobarbital-treated rats were employed. These studies indicate that thyroid hormone metabolism results in the formation of structural and soluble tissue iodoproteins in addition to circulating iodoproteins. The rate of formation of these moieties in the liver and plasma appears to be related to the rate of hormone metabolism.


Estimation of prolactin and growth hormone levels by polyacrylamide disc electrophoresis.


Studies of bilirubin kinetics in normal adults. This report describes studies of bilirubin kinetics in 13 healthy young adults. The plasma content of unconjugated bilirubin-(14)C was determined at frequent intervals for 24-30 hr after the intravenous injection of a tracer dose of unconjugated isotopic bilirubin. Fecal and urinary radioactivity were measured for 7 days. During this time cumulative recovery averaged 96% of the injected dose. The plasma curves were processed by digital computer. For the 30 hr experimental period, a sum of three exponentials, with average half-times of 18, 81, and 578 min, was required to describe the data. Using the plasma curve integral method, the hepatic bilirubin clearance (47 +/-10 ml/min, mean +/-SD), the bilirubin production rate (3.8 +/-0.6 mg/kg per day), and the mean red blood cell life span (101 +/-13 days) were calculated directly from the parameters of this function. To gain further insight into the metabolism of unconjugated bilirubin, the data were also used to determine the parameters of a multicompartmental model. In the model proposed, plasma unconjugated bilirubin exchanges with two additional pools one of which is thought to represent extrahepatic extravascular, and the other intrahepatic unconjugated bilirubin. Bilirubin is eliminated from the system via the proposed intrahepatic pool. From the data and the model, pool sizes and exchange rates between compartments were calculated, and the liver: plasma concentration gradient estimated. These studies provide a detailed analysis of the kinetics of unconjugated bilirubin in a healthy normal population and are intended to serve as a reference point for studies of abnormal states.


Uptake of aldosterone by human skin and stimulation of RNA synthesis in the sweat gland in vitro.


Radioactive inulin, sulphate and chloride spaces and electrolytes in the thyroid gland of rats at different ages.


Effects of amygdaloid lesions on regional brain RNA base ratios.


The influence of pituitary hormones on the response of the sebaceous glands of the male rat to testosterone.


The influence of the pituitary on the response of the sebaceous and preputial glands of the rat to progesterone.


Effects of reserpine upon catecholamine levels in arterial tissue and plasma and upon peripheral blood flow measurements in the anesthetized dog.


The effect of a second dose of cadmium salts on vascular permeability in the rat testis.


The renal handling of phosphate in thyroid disease.


Evaluation of human follicle-stimulating hormone preparations.


Camparison between the bioassay and radioimmunoassay of calcitonin in plasma of several species.


The circadian basis of specific gonadotrophin release in relation to avian spermatogenesis.


Steroidogenesis and morphology of human ovarian cell types in tissue culture.


Effect of testosterone on the cytology of peritoneal fluid in mice.


Interrelationship between hydration, urine flow, renal blood flow and the radiohippuran renogram.


A physiological model for the renal excretion of labeled compounds.


Decreased 14CO2 production in thiamine-deficient rats given pyruvate-1-14C and acetate-1-14C: a possible means for early diagnosis of beri-beri?


99mTc-ferric hydroxide macroaggregates for pulmonary scintiphotography.


The lung scan in alpha-1-antitrypsin deficiency.


Relative function of the "hot" autonomous thyroid nodule: double and single isotope autoradiographic studies.


Low-cost precision linear scanning table.


Sequential determinations of the in situ distribution of 131-I-labeled tetracycline in cats using the scintillation camera.


Mapping myocardial mass and regional coronary blood flow by external monitoring of 42K or 86Rb clearance.


A comparison of the effect of temperature, metabolic inhibitors and of ouabain on the electrogenic componen of the sodium pump in mammalian non-myelinated nerve fibres. 1. A comparison has been made of the effect of cooling, metabolic inhibitors and of ouabain on the electrogenic component of the sodium pump in mammalian non-myelinated nerve fibres.2. The hyperpolarization that occurs during the potassium-activated response that is obtained after a brief period of stimulation (5 sec, 30/sec) in potassium-free solution was taken as an index of the activity of the pump.3. Cooling decreased the amplitude and rate constant of decay of the potassium-activated response. The area of the response, which reflects the total amount of sodium that is extruded after activity, remained constant.4. Exposure to the metabolic inhibitors deoxy-D-glucose and cyanide also decreased the amplitude and rate constant of the response; as with cooling, the area remained relatively constant.5. Ouabain, however, reduced the amplitude without reducing the rate constant, which was even sometimes increased with small concentrations of ouabain. The area of the response always decreased therefore.6. The effects applying metabolic inhibitors are thus similar to those obtained on cooling, but differ from those of ouabain.


Cable properties of external intercostal muscle fibres from myotonic and nonmyotonic goats. 1. In preparations of about 200 fibres each from thirty-nine biopsies of external intercostal muscle taken from nine myotonic and six nonmyotonic goats, cable properties were determined at 38 degrees C for individual fibres with a pair of intracellular micro-electrodes.2. In each preparation the mean fibre dimensions, determined histologically and corrected for shrinkage, were used to calculate the mean membrane resistance, R(m), fibre capacitance, C(t), and myoplasmic resistivity, R(i). In the 124 nonmyotonic fibres the mean values were: R(m), 1897 Omega.cm(2), C(t), 4.1 muF/cm(2), and R(i), 112 Omega.cm. In 151 myotonic fibres R(m) was 5589 Omega.cm(2), C(t), 4.4 muF/cm(2), and R(i), 103 Omega.cm.3. Conductance of the fibre core times unit length increased with cross-sectional area, and fibre capacitance per unit length increased with perimeter. There was little correlation of membrane resistance per unit length of fibre with either fibre perimeter or resting potential.4. The principal abnormality of cable properties in the myotonic fibre is its threefold higher membrane resistance, which accounts for its decreased electrical current rheobase.


Change of tubular reabsorption of sodium and water after renal denervation in the dog. 1. Renal function was compared in dogs before and after denervation, with normal or reduced glomerular filtration rate (GFR). GFR was reduced by one of two means, aortic clamping or injection of plastic microspheres into one renal artery.2. The data showed that the tubular rejection fraction of denervated kidneys increased at a time when the same value for the control kidney decreased, indicating that denervation diuresis is not simply a result of increased filtered load of Na and water.3. Changes in excretion after aortic clamping are not due solely to reduced filtered load. A reduction in renal blood pressure itself appears to have a direct effect on Na transport since Na excretion was significantly decreased before there were any changes in GFR, renal plasma flow and urine volume.4. When GFR in a denervated kidney was reduced by microsphere injection it was demonstrated that a significant natriuresis (U(Na) V) and diuresis (V) occurred when. GFR was reduced by as much as 40%.5. These experiments support the hypothesis that denervation diuresis does not result solely from increased filtered load, but entails altered Na transport.


On the metabolic basis of nervous activity. 1. A study has been made of the metabolic substrates that can support the active extrusion of sodium ions from mammalian non-myelinated nerve fibres. The post-tetanic hyperpolarization obtained in chloride-free Locke solution, which reflects the electrogenic component of the sodium pump, was used as the index of metabolic activity.2. When glucose was removed from the Locke solution there was no immediate change in the size of the post-tetanic hyperpolarization.3. However, glucose is essential for metabolism in nerve fibres; for when a competitive inhibitor, deoxy-D-glucose, was added to the Locke solution the post-tetanic response was much reduced or abolished. Larger concentrations of deoxy-D-glucose were required in the presence of glucose than in its absence.4. This effect of deoxy-D-glucose could be reversed by glucose, fructose, pyruvate and acetate.5. The depressant effect of deoxy-D-glucose was enhanced by oxaloacetate and by malate.6. Malonate, a competitive inhibitor of the conversion of succinate to fumarate, reduced or abolished the post-tetanic hyperpolarization.7. This effect of malonate could be overcome by glucose and by pyruvate.


Trematode cataract in fresh water fish.

Trematode cataract in fresh water fish.


The clearance and antidiuretic potency of neurohypophysial hormones in man, and their plasma binding and stability. 1. Bio-assay techniques have been used to measure plasma levels of neurohypophysial hormones in man, following either a single injection or a continuous infusion.2. The median half-life of oxytocin after a single injection of 2 u. was 3.2 min (2.0-5.7, 95% confidence limits); this increased significantly (P < 0.01) to 4.8 min (4.4-6.1) when the hormone was infused at a rate of 500 m-u./min. The vasopressins had appreciably longer half-lives. After a single injection of 1 or 1.5 u. 8-lysine vasopressin (LVP), the half-life was 5.7 min (3.6-6.0). Continuous infusions of the hormones at a rate of 120 m-u./min yielded half-lives of 5.5 min (5.0-7.1) for LVP, and 5.6 min (3.9-9.5) for 8-arginine vasopressin (AVP).3. The apparent volumes of distribution of the hormones were all of the order of two thirds the extracellular volume.4. In accordance with its shorter half-life, the clearance of oxytocin was greater than that of the vasopressins (1.5 l./min, compared with 1.0 l./min).5. The antidiuretic potencies of the hormones were studied in over-hydrated subjects, by measuring the rate of urine excretion following an I.V. injection. Duration of antidiuretic action increased in the order: oxytocin, LVP, AVP. A 5:1 mixture of oxytocin and AVP was not as long-lasting as AVP alone. 8.5% (4-22) of an administered dose of AVP was excreted in the urine, and this amount was significantly correlated with urine volume (r = +0.67, P < 0.05).6. Ultrafiltration of human plasma containing exogenous hormones showed that 30% (13-50) of AVP was bound, the degree of binding being independent of concentration over the range used (50-400 mu-u./ml.) In contrast, oxytocin was completely unbound.7. Exogenous oxytocin was more stable than exogenous AVP in human plasma. At 4 degrees C there was no significant loss of oxytocin until 7 days, whereas 20% of AVP was inactivated in 2 days. At 37 degrees C a 20% loss of AVP occurred within 4 hr, and a 50% loss within 24 hr; corresponding times for oxytocin were 24 and 48 hr.


A quantitative analysis of the slow component of delayed rectification in frog atrium. 1. The slow component of delayed rectification in the atrial muscle membrane of Rana ridibunda has been analysed quantitatively using a voltage-clamp technique.2. It is shown that the current is proportional to a variable which obeys first-order kinetics. At negative potentials the time constant of this process is very long (tau = 3 sec at -55 mV) but it becomes faster at positive potentials (tau = 1.85 sec at +25 mV).3. In the steady state the degree of activation is a sigmoid function of potential. The activation threshold varies substantially between preparations but is usually negative to -30 mV.4. The instantaneous current-voltage relation is nearly linear and its reversal potential most frequently lies between zero and -30 mV.5. The properties of this current system resemble those of the current system i(x2) found in mammalian Purkinje fibres.


Distribution of granular vesicles in normal and constricted sympathetic neurones. 1. A quantitative analysis has been made of the characteristics of granular vesicles in different parts of normal and ligated post-ganglionic sympathetic neurones supplying the cat spleen. The least diameter of the vesicle membrane and its electron-dense core was measured from electron micrographs with an automated particle size analyser.2. Vesicles of average diameter 443 A, with and without electron-dense cores (192 A), were concentrated in the axon terminals of the spleen, whereas in the cell bodies in the coeliac ganglion and their axons there were only a few large vesicles (787 A) with large granules (562 A).3. Ligation of the splenic nerves for 24 hr resulted in an accumulation proximal to the constriction of granular vesicles significantly larger (688 A) and more completely granulated (478 A) than those in the terminals.4. Reserpine reduced the number of vesicles with granular cores without discrimination between the two populations.5. Since the distribution of noradrenaline in sympathetic neurones can be correlated with the presence of large as well as small granular vesicles, it is suggested that the larger, more granular type found mainly proximally in the neurone is in transit from its perikaryal site of synthesis to the axon terminals, where it is transformed into the smaller synaptic vesicles.


Membrane currents underlying delayed rectification and pace-maker activity in frog atrial muscle. 1. A double sucrose gap method has been used to polarize and voltage clamp frog atrial muscle strips.2. In response to steady depolarizing currents, normally quiescent strips often show pace-maker activity, and long lasting depolarization occurs when the current is terminated.3. Voltage clamp experiments reveal the presence of two current components underlying delayed rectification.4. The first of these components has a time constant which varies with potential and is approximately 500 msec at -90 mV. Its reversal potential usually lies between -70 and -40 mV and has always been found to be positive to the resting potential of normally quiescent fibres.5. The time constant of the second component is extremely slow (tau [unk] 5 sec at -90 mV). Its reversal potential is much more positive than that of the faster component.6. The results confirm the presence of a component of inward current which is insensitive to tetrodotoxin (TTX), having an activation threshold about 20 mV positive to the sodium threshold. This current differs from the two components underlying delayed rectification both in its greater speed of activation and in showing inactivation. The inactivation of this TTX-insensitive current is also a fairly rapid process.7. It is suggested that pace-making in sino-atrial muscle may depend upon the deactivation of the faster component of delayed rectification and that the TTX-insensitive inward current is also involved.


Polydipsia in the dog--symposium. I. The role of the kidneys in the control of water metabolism in mammals.


Nerve-mediated excitation and inhibition of the smooth muscle cells of the avian gizzard. 1. The electrical events evoked in smooth muscle cells of the chick and pigeon gizzards by vagal, perivascular sympathetic and transmural stimulation were recorded with intracellular micro-electrodes.2. Single stimulating pulses applied to the extrinsic nerves, or to intrinsic fibres, produced excitatory junction potentials (E.J.P.s) which were blocked by hyoscine. Repetitive stimulation caused facilitation of E.J.P.s and, at higher frequencies, summation. When the tissue was well oxygenated, maximal stimulation evoked action potentials and the tissue contracted. If the tissue was allowed to become anoxic, action potentials were blocked and thus junctional transmission could be observed uncomplicated by tissue contraction.3. Cholinergic E.J.P.s appeared to be due to stimulation of both post-ganglionic neurones and the pre-ganglionic input to post-ganglionic neurones, since ganglion-blocking drugs abolished the late phase of complex E.J.P.s while leaving unaffected their initial components.4. Repetitive perivascular sympathetic stimulation, after cholinergic E.J.P.s had been blocked by hyoscine, evoked a slow, long-lasting depolarization of the muscle cells. This depolarization was blocked by guanethidine (5 x 10(-6) g/ml.) and was mimicked by noradrenaline (10(-7) g/ml.).5. Under non-anoxic conditions, the tissue underwent rhythmical contractions which were associated with action potential firing. When the tissue was anoxic action potentials were not seen, but spontaneous membrane depolarizations resembling E.J.P.s were observed. Spontaneous miniature excitatory junction potentials (M.E.J.P.s) were observed only infrequently whether the tissue was well oxygenated or not.6. Single stimulating pulses applied to extrinsic or intrinsic nerves frequently evoked inhibitory junction potentials (I.J.P.s) in smooth muscle cells of the gizzards of both birds. I.J.P.s were blocked by tetrodotoxin (10(-7) g/ml.). Repetitive stimulation of inhibitory nerves gave rise to a membrane hyperpolarization; when stimulation was stopped the membrane potential showed rebound depolarization.7. These results are discussed in terms of the autonomic innervation of the avian gizzard, and possible explanations of the various types of activity observed are considered.


Lipoprotein phenotypes.

Lipoprotein phenotypes.


The drug issue.

The drug issue.


Recognizing the suicidal patient.

Recognizing the suicidal patient.


Behavior disorders in children.

Behavior disorders in children.


The adolescent turmoil.

The adolescent turmoil.


Some medical and sociological problems of the urban community.


Grief and depression in old people.

Grief and depression in old people.


Rehabilitation of patients suffering from fracture of the hip. 3. Treatment by prosthetic replacement of the femoral head.


Rehabilitation of patients suffering from fracture of the hip. IV. Treatment by non-surgical methods.


A report to the fifteen Southern states.


Developing meaningful mental health statistics.


Respiratory viral disease.

Respiratory viral disease.


Effect of other drugs on oral anticoagulants.


Rehabilitation of spinal cord injured patients. I. General introduction.


Death from narcotics use. Baltimore city, 1963 through 1968.


The aging face. A surgical approach to rejuvenation.


Sacculotomy in the treatment of Meniere's disease.


Wound disruption after abdominal laparotomies.


Pulmonary fibrosis following radiotherapy for bronchogenic carcinoma and Hodgkin's disease.


Emergency room problems of an "inner core" city hospital. An in-depth analysis of the emergency department, Bon Secours Hospital.


Growth of day care centers for the mentally retarded.


Discipline in approved schools.

Discipline in approved schools.


Home care of chronic respiratory disease.


Chronic respiratory diseases in children.


The Chelsea poisoning case.

The Chelsea poisoning case.


Chronic respiratory disease in children.


Health effects from exposure to air pollutants.


Cigarette smoking and chronic respiratory disease.


Hyaline membrane disease. Danger of a rational approach to therapy.


The National Cystic Fibrosis Research Foundation and chronic respiratory disease in children and adolescents.


Observations of a 28-year-old man with cystic fibrosis.


Public health nursing care of chronically ill children.


Triglycerides, too.

Triglycerides, too.


Etiology of allergic bronchial asthma.

Etiology of allergic bronchial asthma.


Congenital cardiac disease. Causal factor in pediatric pulmonary disease.


Cystic fibrosis. Current theories concerning the pathogenesis.


Physical conditioning course for children with asthma.


Pulmonary function evaluation with 133xenon.


Cystic fibrosis. Pathogenesis of the pulmonary lesion.


Office diagnosis of immunologic deficiency.


The pulmonary function laboratory. Role in the evaluation of pulmonary disease in children.


X-ray diagnosis in the child.

X-ray diagnosis in the child.


Chronic lung disease. Clinical evaluation of the child.


How cystic fibrosis can be confused with chronic bronchitis and bronchial asthma.


Allergic pulmonary disease. Criteria for the diagnosis.


Inhalation therapy for chronic obstructive pulmonary disease.


Obstructive lung disease. Treatment by physical therapy.


Disc sensitivities in the selection of antibiotics.


Management-comprehensive treatment of cystic fibrosis.


Cardiac complications of chronic pulmonary disease in childhood.


Pulmonary complications of cystic fibrosis.


Pulmonary failure in asthma and cystic fibrosis.


Bacteria in the sputum. Pediatric patients with chronic pulmonary disease.


Cystic fibrosis. Surgical treatment of pulmonary complications.


Cystic fibrosis. A new challenge to internal medicine.


Social stigmata of cystic fibrosis.

Social stigmata of cystic fibrosis.


Psychiatric aspects of chronic lung disease.


Respiratory complications of cystic fibrosis. Prevention.


Subclinical pulmonary disease in children. An exercise in "subclinical" logic.


Genetic counseling for parents. Children with cystic fibrosis, agammaglobulinemia, or fatal granulomatous disease of childhood.


Serum lipids in infection.

Serum lipids in infection.


Folliculitis induced by actinomycin D.

Folliculitis induced by actinomycin D.


Tuberculous peritonitis. An evaluation of pathogenetic mechanisms, diagnostic procedures and therapeutic measures.


Reticulocytes and ribosomes.

Reticulocytes and ribosomes.


Bacteremia associated with cardiac catheterization.


Gram-negative sepsis: another piece of the mosaic.


Arboviruses and catalase(s).

Arboviruses and catalase(s).


A vascular vignette.

A vascular vignette.


Lithium content of drinking water and ischemic heart disease.


Comparison of a beta-propiolactone inactivated four-strain with three single-strain Newcastle disease vaccines.


Significance of the bursa of fabricius after whole body x-irradiation.


Serum protein fractions in the normal turkey.


Excretion of bile acids by cockerels fed differentipids.


Some effects on turkeys of nitrate in the drinking water.


The effects of buffer pH and storage time on the electrophoretic properties of embryonic hemoglobin.


Alteration of electrophoretic pattern of plasma aminopeptidase in avian erythroblastosis.


Flavor comparisons in gnotobiotic and conventional broiler chickens.


Acute hypoxia tolerance of the chick.

Acute hypoxia tolerance of the chick.


The effect of reserpine on reproductive performance of Japanese quail.


Kinetics of hydrolysis of p-nitrophenyl phosphate by fowl plasma alkaline phosphatase.


Relationship of turkey eggs showing parthenogenetic development to those containing embryos or hatching.


The effects of gonadal hormones on hyerossification in the domestic fowl.


Effectof prednisolonon growth and nucleic acid metabolism of Pekin ducks.


Endocrine responses of six stocks of chickens reared at different population densities.


The effect of diet on mortality attributed to Marek's disease among leghorn genotyes.


Toxicity of high levels of zinc-65 to avian embryos.


Studies with fish meal as the sole source of protein for the growing chick. I. Effect of different supplements on growth and feed efficiency.


Blood pressure and heart rate of turkeys, 17-21 months of age.


Kidney alkaline phosphatase in mercuric chloride injected chicks resistant and susceptible to leukosis.


Low protein cage-layer diets and amino acids.


Amelioration of Marek's disease by Mycoplasma gallisepticum.


Effect of a high level of dietary ascorbic acid on egg quality.


A cecal anomaly in a white leghorn cockerel.


The effect of feeding various levels of lead on the performancef broilers.


Radiation-induced trapped charge carriers in organic polymers. A model of thermoelectric current generation.


Surgical bursectomy and the incidence of Marek's disease (MD) in domestic chickens.


Excretion of metabolites of tannic acid by chickens with and without ceca.


On the electroencephalogram in the unilateral optic enucleated chick.


Low pressure anomalies in the dosimetry and radiolysis of gases with high intensity electron pulses.


Dose-response relationship for translocations induced by x-irradiation in spermatogonia of mice.


Comparison of the observed results of irradiation on the skin with those expected from an idealized model.


Toxicity of irradiated p-hydroxymercuribenzoate.


Radioprotective effect of a chemical mixture in rats.


Krebs cycle dehydrogenase systems activity in the gastrointestinal tract of rats after whole-body ionizing irradiation.


Growth in prenatally irradiated rats as indicated by changes in cell number and cellular materials.


Effects of thymectomy and x-irradiation on the immune response of mice to sheep erythrocytes.


Leydig-cell tumors in rat testes subjected to low-dose x-irradiation.


Radiobiological investigations on embryonic rat bone grown in vitro.


Oxygen enhancement ratio and RBE of helium ions on mouse lymphoma cells.


Radioprotective effect of sodium fluoroacetate in mice.


Study of the inflexion of x-radiation survival curves for synchronized cell populations of the green alga (Oedogonium cardiacum).


Radiation-induced life-shortening in Drosophila.


Brief note on bronchography.

Brief note on bronchography.


Angiographic evaluation of pancreatic carcinoma.


Video velopharyngography in patients with nasal speech, with emphasis on lateral pharyngeal motion in velopharyngeal closure.


An angiographic roll film cutter.

An angiographic roll film cutter.


Epinephrine-assisted renal venography in renal vein thrombosis: report of two adolescents with nephrotic syndrome.


The arteriographic diagnosis of primary and secondary tumors of the ureter or ureter and renal pelvis.


Mechanism of excretion of radioiodinated sodium iothalamate.


Aberrant renal papilla simulating an intrarenal mass. Report of two cases.


"Tumor vascularity" in left atrial myxoma demonstrated by selective coronary arteriography.


A new image display and analysis system (IDA) for radionuclide imaging.


Collateral pathways between the cavernous portion of the internal carotid and external carotid arteries.


Arteriographic discovery of a small contralateral carotid body tumor.


Estimation of changes in bone calcium content by radiographic densitometry.


Diffuse biarticular pigmented villonodular synovitis.


Unilateral osteoarthritis of the distal interphalangeal joints following frostbite: a case report.


Metastases to the patella.

Metastases to the patella.


Destruction of phalangeal epiphyses by frostbite.


The sigmoid elevator sign: it significance.


Diagnosis of esophageal varices. Improvement of diagnostic accuracy by cinefluorography.


Choledochal cysts demonstrated by oral cholecystography.


Laryngeal cyst (filled laryngocele): a laryngographic diagnosis.


Left testicular vein varices simulating retroperitoneal lymph-node enlargement.


Chromosomal aberrations induced by plasma from irradiated patients: an indirect effect of X radiation. Further observations and studies of a control population.


Radiation effects on lymphopoiesis under continuous low dose rate exposure.


Radiation therapy in carcinoma of the false cord.


Carcinoma of the breast following simple mastectomy and mammoplasty: case report.


RPC of the month from the AFIP.

RPC of the month from the AFIP.


The magnetically guided bronchial catheter of modified POD design. A new approach to selective bronchography.


Celiac pancreatography: a preliminary report.


Guided catheter system for selective bronchial brushing and bronchography.


Catheter tip deflector system for selective bronchography.


The core of radiological learning.

The core of radiological learning.


Transfemoral internal thoracic (mammary) arteriography.


An appraisal of diagnostic training programs: residents' viewpoint.


Isolated perfusion of the canine stomach.


Measurement of coronary collateral blood flow using radioactive rubidium chloride.


Pyloroplasty without muscle closure.

Pyloroplasty without muscle closure.


Diverticulitis of the colon.

Diverticulitis of the colon.


Dual origin of ascites in hepatic cirrhosis.


Management of the colonic stoma.

Management of the colonic stoma.


Atraumatic iliac artery occlusion.

Atraumatic iliac artery occlusion.


Seromuscular folding technique for ureterosigmoid anastomosis.


The low recurrence rate of colonic carcinoma in ileocolic anastomoses.


Adnexal abscess as a late complication of pelvic operations.


Vascular responses to potassium ion.

Vascular responses to potassium ion.


Infection of baby mice with Schistosoma mansoni; some biological aspects in connection with experimental chemotherapy.


Treatment of Schistosoma haematobium infection with astiban in Iraqis.


Massive retroperitoneal adrenal hemorrhage.


Neuropsychiatric effects and E.E.G. changes in niridazole therapy.


The in vitro action of antisera on the adults of Clonorchis sinensis.


A quantitative approach to the epidemiology of onchocerciasis in West Africa.


Microfilarial levels in cats infected with Brugia pahangi by two alternative routes.


Local skin reactions in cattle at the site of infection with Trypanosoma congolense by Glossina morsitans and G. tachinoides.


Amoebic colitis: review of 295 cases.

Amoebic colitis: review of 295 cases.


Murine typhus in Thailand.

Murine typhus in Thailand.


Studies of normal carbohydrate tolerance in the Ugandan African.


The occurrence and recognition of endomyocardial fibrosis of the right ventricle in coastal Tanzania.


A toxoplasmin skin test among the Sudanese.


Unknown filarial larvae and zoophily in Simulium damnosum in Liberia.


Myasthenia gravis in Kenya.

Myasthenia gravis in Kenya.


Two cases of Plasmodium ovale malaria from central Thailand.


Experimental lymphoedema in dogs infected with Brugia spp.


Surgical treatment of epilepsy: principles and review of patients.


Clinical therapeutic conditioning in epilepsy.


Clinical diagnosis in epilepsy.

Clinical diagnosis in epilepsy.


Neuropsychological evaluation of the epileptic patient.


Subacute thyroiditis.

Subacute thyroiditis.


Ion transport and lipid content of isolated frog skin.


Effects of diet and catecholamines on bile acid metabolism in dogs.


Site of amino acid transfer in dog parotid glands.


Effects of temperature on series elasticity and contractile element motion in heart muscle.


Buffering capacity of cerebrospinal fluid in acute respiratory acidosis in dogs.


Metabolism of the isolated canine lung.

Metabolism of the isolated canine lung.


Iodopyracet transport by isolated perfused flounder proximal renal tubules.


p-Aminohippurate uptake and exchange by separated renal tubules.


Characteristics of p-aminohippurate transport in proximal renal tubules.


Changes in conductances of frog sartorius fibers produced by CO2, ReO4-, and temperature.


Low K+ conductance and low resting potentials of isolated single cultured heart cells.


Sulfate accumulation by mouse intestine: influence of age and other factors.


Altered composition and lipolysis of adipose tissue from gold thioglucose obese mice.


Effect of exogenous and endogenous secretin on gastric and pancreatic secretion in cats.


Effect of ammonium chloride on rubidium-induced changes in muscle cell bicarbonate.


Effects of luteinizing hormone on multiple-unit activity in the rat hypothalamus.


Rapid effects of insulin on the hypothalamic satiety center.


Forehead blood flow measured by radioisotope disappearance rates.


Coronary flow as an independent determinant of myocardial contractile force.


Phosphate-independent, carrier-mediated active transport of calcium by rat intestine.


Effects of high-carbohydrate diets on lipid and carbohydrate metabolism in the rat.


Respiration during transient perfusion of vertebral arteries with hypocapnic blood.


Hereditary vasopressin-resistant urinary concentrating defects in mice.


Renal excretion of cystathionine in dogs.


Effect of osmolarity on canine renal vascular resistance.


Influence of blood pH on adrenomedullary response to hemorrhage.


Mechanics of small intestinal muscle function in the dog.


Extracellular volume and ionic content of frog ventricle.


Bioenergetics and body size in dasyruid marsupials.


Membrane excitability of the frog ventricle examined by long pulses.


Modification of cecal size in germfree rats by long-term feeding of anion exchange resin.


Oxidation of radioactive palmitate and glucose infused into the cortical subarachnoid space.


In vitro inactivation of pancreatic enzymes in washings of the rat small intestine.


Sympathetic control of ventricular automaticity: role of the adrenal medulla.


Interactions of amphotericin B, vasopressin, and calcium in toad urinary bladder.


Alanine transport in rabbit jejunum.

Alanine transport in rabbit jejunum.


Insulin-induced acid secretion after partial vagotomy in dogs and cats.


Chromatographic fractions of bee venom: cytotoxicity for mouse bone marrow stem cells.


Mechanisms of intra-arterial Kplus-induced cardiovascular and respiratory responses.


Carotid artery surgery.

Carotid artery surgery.


Transport of neutral amino acids from feline cerebrospinal fluid.


Surgical significance of extraluminal aortic perfusion after acute thoracic aortic dissection.


The acutely symptomatic aneurysm; a surgical emergency.


Basilar artery insufficiency due to atlanto-occipital instability.


"Too much water".

"Too much water".


Treatment of hydrocephalus: direct attach on the obstruction.


Studies in burns VII: the "water-retaining" lipids of eschar: their presence and potential usefulness.