Reduction of exogenous water and solute requirements during elective operations, with postoperative enhancement of peripheral red cell mass.


Diagnostic wound tract radiopaque media injection roentgenography in penetrating wounds.


Salivary gland scintigram in inflammatory disease.


Prostatism and infected urachal cyst: a differential diagnosis.


Physiology of the calf veins.

Physiology of the calf veins.


The fallacious T-wave and the second sound.


Measurement of intrahepatic shunted blood flow by means of heat-denatured radioiodinated serum albumin in experimental hepatic injuries.


The sensitivity of the arterial and venous coronary circulation to KCN.


Gangrene in ischemic disease of the lower extremities.


Structure of the leptomeninx and cerebral vessels of the cat. II. Constituent elements of the intracerebral vessel wall (analogy with the meninges).


Electroencephalographic study of dose-response relations for cyclandelate on hyperventilation-induced vasospasm in human brain.


Studies on the effect of temperature on the red clover mottle virus in vivo and in vitro.


Models, inference, and strategy.

Models, inference, and strategy.


Measurement of the potencies of drug mixtures.


Analysis of categorical data by linear models.


The effect of unequal variance-covariance matrices on Fisher's linear discriminant function.


Comparison of sequential rules for estimation of the size of a population.


Mammalian reproductive data fitted to a mathematical model.


Genetic components for non-inbred diploid species when the expectations for the epistatic variance are restricted.


A generalization of the logistic law of growth.


The prediction of response to selection in breeding programmes when all daughters of selected parents are retained.


On the efficiency of modified BIB designs for bio-assays.


Linear regression on proportions.

Linear regression on proportions.


Subthreshold oscillatory responses of the Hodgkin-Huxley cable model for the squid giant axon. The classical cable equation, in which membrane conductance is considered constant, is modified by including the linearized effect of membrane potential on sodium and potassium ionic currents, as formulated in the Hodgkin-Huxley equations for the squid giant axon. The resulting partial differential equation is solved by numerical inversion of the Laplace transform of the voltage response to current and voltage inputs. The voltage response is computed for voltage step, current step, and current pulse inputs, and the effect of temperature on the response to a current step input is also calculated.The validity of the linearized approximation is examined by comparing the linearized response to a current step input with the solution of the nonlinear partial differential cable equation for various subthreshold current step inputs.All the computed responses for the squid giant axon show oscillatory behavior and depart significantly from what is predicted on the basis of the classical cable equation. The linearization procedure, coupled with numerical inversion of the Laplace transform, proves to be a convenient approach which predicts at least qualitatively the subthreshold behavior of the nonlinear system.


Pancreatic ribonuclease-poly G complexes: complete inhibition of poly U hydrolysis. Pancreatic ribonuclease forms large complexes with poly G in 0.1 M acetate buffer solutions (pH 5.4). These are largest when the ratio, of ribonuclease to poly G concentration, is slightly less than 2. Under the same conditions lysozyme forms still larger complexes with poly U, and these are largest when the ratio, of lysozyme to poly U concentration, is about 2.5. The ribonuclease in ribonuclease-poly G complexes digests poly U. Free ribonuclease digests the poly U in lysozyme-poly U complexes. However, when the poly G concentration is about an order of magnitude greater than that required to bind all the ribonuclease, lysozyme-bound poly U is not hydrolyzed.


Statistical analysis of motor unit firing patterns in a human skeletal muscle. A statistical analysis of the firing pattern of single motor units in the human brachial biceps muscle is presented. Single motor unit spike trains are recorded and analyzed. The statistical treatment of these spike trains is as stochastic point processes, the theory of which is briefly discussed. Evidence is presented that motor unit spike trains may be modelled by a renewal process with an underlying gaussian probability density. Statistical independence of successive interspike intervals is shown using scatter diagrams; the hypothesis of a gaussian distribution is accepted at the 99th percentile confidence limit, chi-square test, in 90% of the units tested. A functional relationship between the mean and standard deviation is shown and discussed; its implications in obtaining sample size are presented in an appendix.The results of higher order analysis in the form of autocorrelograms and grouped interval histograms are presented. Grouped interval histograms are discussed in the context of motor unit data, and used to confirm the hypothesis that a stable probability density function does not represent a good model of the data at this level of analysis.


Statistical-mechanical studies of the alpha-beta transformation in keratin. IV. The Hill model. The relationship between the two-dimensional Hill model and the David-Schor extension of the one-dimensional Zimm-Bragg model for the alpha right arrow over left arrow beta transformation in keratins is developed. On the basis of the assumptions of the David Schor model, it appears unlikely that the Hill model in its present form can give detailed agreement with the experimental tension-length isotherms.


Nuclear magnetic resonance studies of sodium ions in isolated frog muscle and liver. Nuclear magnetic resonance (NMR) was used to determine Na(+) complexing in muscle and liver (at 23 degrees C) from bullfrogs (Rana catesbeiana) and to study the influence of temperature on Na(+) complexing in muscle from leopard frogs (Rana pipiens). The Na(+) complexed in muscle and liver was found to be 36.6 +/- 4.6% and 66.1 +/- 3.5% respectively. A temperature decrease from +34 degrees C to -2 degrees C results in a 20% decrease in the mobility of the free Na(+) in the fresh muscle. This 20% decrease in mobility results in about 50% of the free Na(+) at 34 degrees C being complexed at the lower temperature.


Flow through a collapsible tube. Experimental analysis and mathematical model. Flow through thin-wall axisymmetric tubes has long been of interest to physiologists. Analysis is complicated by the fact that such tubes will collapse when the transmural pressure (internal minus external pressure) is near zero. Because of the absence of any body of related knowledge in other sciences or engineering, previous workers have directed their efforts towards experimental studies of flow in collapsible tubes. More recently, some attention has been given towards analytical studies. Results of an extensive series of experiments show that the significant system parameter is transmural pressure. The cross-sectional area of the tube depends upon the transmural pressure, and changes in cross-section in turn affect the flow geometry. Based on experimental studies, a lumped parameter system model is proposed for the collapsible tube. The mathematical model is simulated on a hybrid computer. Experimental data were used to define the functional relationship between cross-sectional area and transmural pressure as well as the relation between the energy loss coefficient and cross-sectional area. Computer results confirm the validity of the model for both steady and transient flow conditions.


Regulation of biosynthesis of secondary metabolites. I. Biosynthesis of chlortetracycline and tricarboxylic acid cycle activity.


The response by microorganisms to steady state growth in controlled concentrations of oxygen and glucose. I. Candida utilis.


Oxygen transfer in Streptomyces fermentation broths.


Fluid dynamics of anaerobic fermentation.


Increased oxygen mass transfer rates from single bubbles in microbial systems at low reynolds numbers.


Use of pH and pE measurements during methane biosynthesis.


The foams of fermentation broths. I. Some parameters of the foaming of fermentation media.


The rheological effects of substrate-additives on fermentation yields.


Diffusion models for heterogeneous biochemical reaction kinetics.


Developmental norms for 15 neuropsychological tests age 6 to 15.


Impaired recognition of written letters following unilateral hemispheric damage.


Frequency, picturability and availability of nouns in aphasia.


The relationship of unilateral usage and tactile sensitivity to right-left discrimination and spatial abilities.


Visual memory, verbal encoding and hemispheric localization.


Insulin immunoassay by back-titration using alcohol precipitation of insulin-antibody complexes.


Plasma disappearance rate of injected human insulin in juvenile diabetic, maturity-onset diabetic and nondiabetic subjects.


The effects of brain damage on the phantom limb.


Chemical and early overt diabetes mellitus in children. II. Effect of intravenous tolbutamide on "insulin reserve".


Interrelationship of vascular disease and blood lipids in young indian diabetics.


Lethal effect of heterologous nuclei in amoeba heterokaryons.


Chemical and early overt diabetes mellitus in children. I. Effect of glucagon on "insulin reserve".


Cotton-wool spots in diabetic retinopathy.


Mitotic synchrony in Nalegleria amebae.

Mitotic synchrony in Nalegleria amebae.


Phytohemagglutinin response of recirculating and non-recirculating rat lymphocytes.


The intracellular distribution of the free amino acid pool in frog oocytes.


A relationship between amino acid and sodium transport in Tetrahymena pyriformis.


Uptake and incorporation of leucine and thymidine in developing sea urchin eggs. The effect of D2O.


Oxidation of glutathione in Ehrlich ascites tumor cells by methyl phenyldiazenecarboxylate (azoester).


The uterine epithelium of Ascaris lumbricoides as a model system for the study of polyploidy.


On the regulation of ribosomal RNA synthesis in yeast.


Effects of laser micro-irradiation on chromosomes.


Phagocytosis of modified erythrocytes by macrophages and L2 cells.


On the mechanism of hormone action. 13. Stimulating effects of ecdysone, juvenile hormone and ions on RNA synthesis in fat body cell nuclei from Calliphora erythrocephala isolated by a filtration technique.


The macronuclear envelope of Tetrahymena pyriformis GL in different physiological states. I. Quantitative structural data.


Phototactic response of Euglena to single and repetitive pulses of actinic light: orientation time and mechanism.


Actinomycin binding properties of stimulated human lymphocytes.


Quantitative morphologic studies during colonial growth of heteroploid cell strains differing in cell contact, shape and orientation.


Isolation and characterization of nuclei from bird erythrocytes.


Computer analysis of animal cell movement in vitro.


Evidence against the existence of guanosine and inosine kinases in human fibroblasts in tissue culture.


Nucleoprotein changes and initiation of RNA synthesis in PHA stimulated lymphocytes.


Studies on micronuclei induced by mitomycin-C in the root cells of Vicia faba.


Facing the challenge of today.

Facing the challenge of today.


A cooperative for mental health. The College Center Boston, Massachusetts.


A comprehensive community plan. Mental Health and Retardation Division State Department of Health Bismarck, North Dakota.


Educating disturbed children. Winterode School Crownsville State Hospital Crownsville, Maryland.


The usefulness of comparative hospital data.


Leadership training for patient government.


Development of a British therapeutic community.


Job placement is an individual matter.

Job placement is an individual matter.


A community center operates a halfway house.


Estimating dietary labor by use of work modules.


Estimating food costs by computer.

Estimating food costs by computer.


NASA clean room techniques reduce OR contamination.


Fire hazards in oxygen-enriched atmospheres.


Imaginative rehabilitation--ECF patients enjoy active social program.


International link in education.

International link in education.


The new JCAH standards.

The new JCAH standards.


Microbiological contamination control in hospitals. 1. Perspectives.


The challenge of hospital public relations. 2. How and where to tell the story.


A look at hospital paging systems.

A look at hospital paging systems.


Food preparation: labor time versus production quantity.


Anemia in a population of low socio-economic status.


Iron absorption: effect of anemia and succinic acid.


Blood fibrinolytic activity in diabetes mellitus.


Fibrinolytic activity in acute renal failure.


Influence of sex on hepatic injury in albino rats.


Hydatid disease. A comparative review of its incidence in Ahmedabad with that in other parts of India.


Hemostatic mechanism in uremia.

Hemostatic mechanism in uremia.


Pseudomonas pyocynea septicaemia in young chicks.


Pathogenesis of anaemia in anaplasma infection II--Auto-antibody and anaemia.


Starch-agar gel electrophoretic patterns of blood serum proteins of buffaloes.


A preliminary study on the breeding performance of white Yorkshire pigs in Rajasthan.


Studies on the effect of washing eggs with different detergent and sanitizer mixtures on microbial load and keeping quality of sheel eggs.


Medical eye care is only partial visual care.


Choosing an ophthalmoscope.

Choosing an ophthalmoscope.


Eye hazards of airborne radar.

Eye hazards of airborne radar.


Eikonometer measurements in anisometropes with spectacles and contact lenses.


Neurological organization exercises on retarded children with strabismus.


The effects of pH on contact lens wearing.


The national maritime union pension and welfare plan vision care program.


Now we're in agreement.

Now we're in agreement.


Hiring and training your optometric aide.


Tell it like it is.

Tell it like it is.


How to select a retinoscope.

How to select a retinoscope.


The effect of thyroxine on ribonucleic acid synthesis by premetamorphic tadpole liver cell suspensions.


Independent modification of the binding sites for adenosine diphosphate and L-threonine in threonine dehydratase.


Yeast pyruvate kinase. I. Purification and some chemical properties.


Yeast pyruvate kinase. II. Kinetic properties.


Potentiometric study of equilibria in aqueous solution between copper (II) ions, L (or D)-histidine and L-threonine and their mixtures.


Effect of polymer size on the inhibition of protocollagen proline hydroxylase by polyproline II.


Protein synthesis in the early prereplicative phase of isoproterenol-stimulated synthesis of deoxyribonucleic acid.


The association of deoxyribonucleic acid with liver microsomes.


Thyroidal phenylpyruvate tautomerase. Isolation and characterization.


Chemical studies of histone methylation. Evidence for the occurrence of 3-methylhistidine in avian erythrocyte histone fractions.


Histone biosynthesis in the mammary gland during development and lactation.


Phosphopentomutases. I. Identification of two activities in rabbit tissues.


Endocrine modification of the developmental formation of ornithine aminotransferase in rat tissues.


Biosynthesis of monogalactosyl diglycerides in photoauxotrophic Euglena gracilis.


Methyl viologen-linked sulfite reductase from spinach leaves.


The role of 3-methyleneoxindole in auxin action.


Galactomuramic acid. Chemical synthesis, properties, assay, and survey in several bacterial species.


Isolation and composition of a photosynthetic reaction center complex from Rhodopseudomonas spheroides.


Investigations of yeast L-lactate dehydrogenase (cytochrome b2). VI. Circular dichroism of the holoenzyme.


Biosynthesis of cellulose in vitro from guanosine diphosphate D-glucose with enzymic preparations from Phaseolus aureus and Lupinus albus.


A sialic acid-free beta 1-glycoprotein of normal human plasma.


Hydrogen exchange in proteins as a measure of solvent exclusion due to ligands. Nuclease and myoglobin.


The estimation of polypeptide chain molecular weights by gel filtration in 6 M guanidine hydrochloride.


Ion transport by heart mitochondria. XVI. Cation binding by submitochondrial particles.


Properties of deoxyribonuclease 3 from mammalian tissues.


Observations on molecular weight determinations on polyacrylamide gel.


Oxidation of the sulfhydryl and disulfide groups by the nitroxyl radical.


Changes in the distribution of transfer ribonucleic acid species specifically induced by thyroxine.


Interaction of human hemoglobin with adenine nucleotides.


Hypoglycaemic action of oxytetracycline. A preliminary study.


Clinical electromyography. Principles and diagnostic applications.


Young insulin-refractory diabetics.

Young insulin-refractory diabetics.


Physiological control of diabetes in Indians.


Sensitivity of bacteria from urinary tract infections to hexamine mandelate and some common antibiotics.


EEG--its use and abuse.

EEG--its use and abuse.


Successful cardiac resuscitation by external cardiac massage and mouth-to-mouth breathing.


Deployment of medical officers in rural areas.


In vitro studies on highly resistant small colony variants of Staphylococcus aureus resistant to methicillin.


A national bacteremia registry.

A national bacteremia registry.


The doctor-patient relationship in the treatment of alcoholism.


Medical management of the effects of alcohol and alcoholism.


Immunization program of the State Health Department.


Ventricular septal defect and ventricular aneurysm following myocardial infarction.


Pelvic pneumography identifying an ovarian corpus luteum cyst.


Advertising in medical journals.

Advertising in medical journals.


Surgical treatment of otosclerosis. A follow-up.


Surgery in patients treated with cortisone or cortisone-like steroids. A 10-years study.


Stereoselective metabolism of the enantiomers of hexobarbital.


The effect of tolerance and withdrawal on the in vivo metabolism of N-C14-methyl-dihydro-morphine in the rat.


Studies on the mechanism of phenobarbital-induced protection against parathion in adult female rats.


Tolerance to opioid narcotics. I. Tolerance to the "running fit" caused by levorphanol in the mouse.


Enhancement by cesium ions of ganglionic hyperpolarization induced by dimethylphenylpiperazinium (DMPP) and repetitive preganglionic stimulation.


Dependence of tetrodotoxin blockage of nerve membrane conductance on external pH.


Electrical field-stimulated release of norepinephrine-H3 from rat atrium: effects of ions and drugs.


The uptake and disposition of dl-norepinephrine in perfused rat lung.


Bradykinin on isolated guinea-pig tracheal muscle.


Effect of benzolamide on cerebrospinal fluid formation.


The effect of general anesthesia on the chemical composition of blood plasma of normal rabbits.


The action of ouabain on the function of the atrioventricular node in rabbits.


Effects of nicotine injected into the atrioventricular node artery of the dog.


Effects of ouabain on the splanchnic circulation.


Optical changes in the voltage-clamped squid axon.


Active potassium transport and the development of m antigen on red cells of LK type lambs.


Evidence for the release of vesicle-proteins together with noradrenaline upon stimulation of the splenic nerve.


Enzymic oxidation of amines in Cyclostomes.


Isolation of peripheral synaptosomes from a sympathetically innervated tissue.


The effect of noradrenaline and 5-hydroxytryptamine on local hypothalamic blood flow in the conscious rabbit.


Cardiovascular effects of prostaglandins infused into extra-cranial arteries of the dog.


The permeability to human serum albumin (HSA) and polyvinylpyrrolidone (PVP) of skeletal muscle (rat cremaster) blood vessel walls.


Pressure flow relations in branched tubes.


High energy phosphate resynthesis from anaerobic glycolysis in muscle.


Light-induced changes in the structure of the retinal rod membrane.


Active transport by dietary-restricted rat small intestine.


Dark adaptation: free opsin or regeneration rate?


Triple inhibitory innervation of insect muscle.


Autonomic responses evoked by stimulation of fastigial nuclei in the anaesthetized cat.


Reconstruction of the actions of adrenaline and calcium on cardiac pacemaker potentials.


The direct and crossed components of the reflex increase in phrenic nerve activity following stimulation of the carotid body chemoreceptors in the dog.


uman renal diurnal rhythms at the equator.


Ventilatory response to hypercapnia in acutely and chronically phrenicotomized rabbits.


Spontaneous and evoked oscillations in respiratory and sympathetic discharge.


Vagal deflation reflexes mediated by lung irritant receptors.


Some metabolic responses of motor neurones to axotomy and to botulinum toxin after nerve transplantation.


Mechanism responsible for the stability of the concentration of potassium in cerebrospinal fluid.


Distribution of corticosterone in peripheral blood and in adrenal venous blood of the rat.


The effects of alterations in hypothalamic monoamine content on fever in the rabbit.


Water conservation and the structure of the kidneys of tropical bovids.


Visibility of aperiodic patterns compared with that of sinusoidal gratings. 1. Using experimental curves relating the threshold contrast of sinusoidal grating patterns to their spatial frequency, the expected threshold contrast curves for three aperiodic patterns, viz. a single half-cycle sinusoid bar, a single full-cycle sinusoid bar, and the boundary between an extended sinusoidal grating and a 50% grey surround, are calculated. In this calculation the assumption is made that the system is linear near the threshold.2. Experiments are described in which the actual threshold contrast curves are determined for these aperiodic patterns by three observers. The patterns were generated on the face of an oscilloscope and could be varied in size and contrast.3. These experimental curves agree well with the predictions in the high frequency region (i.e. above about 10 c/deg), but below this various complicating factors restrict the validity of the calculations.4. Thus there is no reason to suppose that a linear theory cannot be used to predict visibility of aperiodic patterns near threshold.


Sodium pumps in the rat small intestine in relation to hexose transfer and metabolism. 1. The nature of Na transfer across rat jejunum was studied by measuring the Na and fluid transfers and the electrical potential in the presence of galactose, mannose and glucose.2. Galactose, actively transferred but not metabolized, caused an increase in the potential but no change in Na transfer or tissue resistance.3. Mannose, not actively transferred but metabolized, caused a large increase in Na and fluid transfer without affecting the potential or tissue resistance. Similar results were obtained with glucose in the presence of phlorrhizin.4. Galactose in the presence of mannose increased fluid and Na transfer to the level found with glucose, which is both actively transferred and metabolized.5. These results are consistent with the view that there are two Na pumps associated with hexoses in rat jejunum, both moving Na towards the serosal side. One is an electrogenic pump, stimulated by hexose transfer, and which results in a rise in potential, and the other is a neutral pump which is stimulated by hexose metabolism and which does not affect the potential.


Gustatory impulse discharges in response to saccharin in rats and hamsters. 1. Impulse discharges produced by saccharin sodium as well as four basic gustatory stimuli were recorded in chorda tympani fibres of rats and hamsters.2. Units predominantly sensitive to NaCl showed a concentration-response magnitude curve for saccharin sodium similar in shape to that for NaCl but smaller in magnitude. Units of this category did not respond to 0.01 M saccharin buffered with tris(hydroxymethyl)aminomethane. Response to saccharin sodium in these units are considered to result from stimulation of receptor molecules by Na ions.3. Units predominantly sensitive to sucrose showed a concentration-response magnitude curve for saccharin sodium with a maximum magnitude at about 0.01-0.1 M. Impulse discharges produced by sucrose and saccharin sodium showed rhythmic burst-like firing. Units of this category responded well to 0.01 M saccharin. Responses to saccharin sodium in these units are attributed to the reaction between saccharin molecules and receptor sites.4. The optimum concentration at which a greatest response magnitude was found varies from one unit to the other and is inversely related to sucrose sensitivity, units highly sensitive to sucrose showing a low optimal concentration. Presence of the optimum concentration is explained by a mechanism known as the non-competitive auto-inhibition.5. Off-responses were observed in units predominantly sensitive to sucrose when 0.03-1 M saccharin sodium applied to the tongue was rinsed with water.6. Neural information for saccharin sodium is described quantitatively in relation to that for four basic gustatory stimuli.


Dynamic properties of fast and slow skeletal muscles of the rat after nerve cross-union. 1. The properties of self-innervated (S-EDL, S-SOL) and cross-innervated (X-EDL, X-SOL) extensor digitorum longus (EDL) and soleus (SOL) muscles have been determined at various times between 25 and 490 days after operations, and these are compared with the properties of normal muscles from unoperated animals of about the same age.2. The muscle fibres of X-SOL were 1.15 times longer than fibres of N-SOL and S-SOL at about 480 days after operations but the diameter of fibres was the same in the three muscles.3. The length of muscle fibres was the same in X-EDL, N-EDL and S-EDL 480 days after operations but the fibres of X-EDL failed to grow in cross-sectional area after innervation by soleus nerve fibres.4. The twitch: tetanus ratio was altered transitorily in both X-EDL and X-SOL but returned to near normal values within about 300 days after operations.5. The time courses of isometric contractions and the force: velocity properties were virtually the same in normal and self-innervated muscles 480 days after operations. The isometric twitch contraction time was about 13 msec for N-EDL, 25 msec for X-EDL, 34 msec for N-SOL and 15 msec for X-SOL, and the intrinsic speed of shortening of sarcomeres was about 45.1 mu/sec for N-EDL, 22.5 mu/sec for X-EDL, 19.8 mu/sec for N-SOL and 33.8 mu/sec for X-SOL; in these respects there was incomplete transformation of EDL to a slow muscle and of SOL to a fast muscle.6. There was a high degree of correlation between the intrinsic speed of shortening of sarcomeres and the isometric twitch contraction time but there was no correlation between isometric twitch contraction time and twitch: tetanus ratio of self-innervated and cross-innervated muscles 200-480 days after operations, and normal muscles from unoperated animals of the same age.7. The relation between intrinsic speed of shortening of sarcomeres and isometric twitch contraction time was approximately hyperbolic for normal, self-innervated and cross-innervated EDL and SOL muscles 480 days after operations.8. The maximum speed of shortening of whole muscle fibres was the same for X-SOL, S-EDL and N-EDL, and the same for X-EDL, S-SOL and N-SOL. The possibility that a neural influence determines the speed of shortening of whole fibres is discussed.


The partition of uterine blood flow in the pregnant rabbit. 1. In pregnant rabbits near term, cardiac output and its distribution were measured by injection of isotope-labelled microspheres into the left ventricle. Hypoxaemia (mean P(a,O2) 35 mm Hg) caused a reduction in placental and renal flows, while myometrial flow was unchanged and coronary and cerebral blood flows increased.2. In the lateral (ovarian) end of the uterine horn foetal and placental weight and absolute maternal placental blood flow were greater than in intermediate or medial positions. Placental flow (per 100 g placental tissue) was most in the most lateral placenta and decreased in the intermediate positions, especially when there were many placentas in the same horn.3. Abortions and runts (more than 2 S.D. below the mean weight for their age) occurred most often in the medial end of the uterine horn, while oversize foetuses (more than 2 S.D. above the mean weight) usually occupied the most lateral position.4. Ovarian blood flow (460 ml./100 g. min) was relatively large (e.g. compared with renal flow, 275 ml./100 g.min).


Potential differences between mother and foetus at different gestational ages in the rat, rabbit and guinea-pig. 1. Potential differences associated with fluid compartments of rat, rabbit and guinea-pig conceptuses have been measured. [Na(+)] and [Cl(-)] in maternal plasma and amniotic fluid from these three species were also determined.2. Transplacental potential differences of about 15 mV (foetus positive) were found in the rat, of approximately 0 mV in the rabbit, and of about 18 mV (foetus negative) in the guinea-pig.3. Amniotic fluid potential differences appeared to arise indirectly from the transplacental potential difference in the rat, from the foetal gastric mucosa in the rabbit, and possibly from the foetal gastric mucosa and indirectly from the placenta in the guinea-pig.4. The results are discussed in the context of Na(+) transfer to the foetus, and on this basis tend to question the general assumption that almost all Na(+) reaching the foetus passes across the placenta.


The isolation of a substance very closely resembling the 18-monoacetate of D-aldosterone from the venous blood of activated muscle and from contracting muscle. 1. A renally active substance can be extracted in detectable quantity from 150 g flash-frozen active but not from 150 g flash-frozen flaccid striped muscle. This substance is identical to the 18-monoacetate of D-aldosterone (18-MA) in R(F) value in three solvent systems and in biological activity.2. The renally active substance is secreted into the blood stream by active but not by flaccid muscles.3. Bilateral stimulation of decentralized sciatic nerves causes diuresis, natriuresis, a rise in the clearances of creatinine and PAH without change in heart or respiratory rates, in cats under chloralose anaesthesia. These changes can be matched by I.V. infusion of ADH, 0.3-0.45 m-u./kg.min.4. The urinary changes caused by sciatic stimulation are not prevented by transection of the spinal cord but are abolished by hypophysectomy.5. Hence, like 18-MA, the muscle substance liberates ADH from the neurohypophysis.


The effects of length and stimulus rate on tension in the isometric cat soleus muscle. 1. By subdividing ventral roots and supplying stimulating pulses to different groups of motor units in rotation, smooth contractions of soleus could be obtained with low rates of stimulation.2. Isometric tension was recorded with different rates of stimulation, and at different muscle lengths.3. Longitudinal histological sections were cut from muscles fixed at different lengths, and sarcomeres were measured. Mean sarcomere lengths in soleus could then be related to the angle at the ankle.4. At high rates of stimulation the maximum active tension was obtained at a length corresponding to an angle of about 60 degrees at the ankle, and a mean sarcomere length of about 2.8 mu. The isometric tension fell only slightly on shortening the muscle to a length equivalent to 100 degrees , and a mean sarcomere length about 2.3 mu. Further shortening caused a marked fall in tension.5. There was a reciprocal relationship between stimulus rate and muscle length; when the muscle was long low rates of stimulation gave near maximal tension, whereas at short lengths the maximum tension was reached only when the stimulus rate was very high. It is suggested that stimulating pulses activate the contractile machinery of the muscle more effectively at long than at short muscle lengths.6. When at low rates of stimulation pulses were distributed among the motor units in rotation to give a smooth contraction, the tension rose higher than during the unfused tetanus that accompanied synchronous stimulation of the same motor units at the same rate. It is suggested that in an unfused tetanus internal movement of the muscle reduces the tension below that developed in a truly isometric state.7. The rate of rise of tension in an isometric tetanus varied with both muscle length and rate of stimulation. At each stimulus rate there was a range of lengths in which the isometric tension developed slowly, this was the same length range in which, at that stimulus rate, the length tension curve was steep.


The mechanical properties of cat soleus muscle during controlled lengthening and shortening movements. 1. By supplying pulses to different subdivisions of the ventral nerve roots in rotation, it was possible to obtain smooth contractions of cat soleus with low rates of stimulation.2. After contracting isometrically the muscle was subjected to constant velocity lengthening or shortening movements.3. During shortening the tension always fell below the isometric value. The fall in tension was usually greatest when low rates of stimulation were used.4. The effect of lengthening on tension depended on the rate of stimulation. At high rates of stimulation the tension during lengthening always rose above the isometric tension. At lower rates of stimulation (5-15 pulses/sec) the tension rose at the beginning of an extension, but decreased later in the movement to a level that was often less than the isometric tension corresponding to that muscle length. At these stimulus rates the tension during isometric contraction was usually higher than during a sustained movement in either direction.5. At low rates of stimulation longitudinal vibratory movements of more than 0.1 mm also reduced the tension far below the isometric value, whereas the reduction was quite slight when the rate of stimulation was high.6. The isometric tension during smooth contractions at low stimulus rates was remarkable in the following respects: it developed rather slowly, it was higher than the tension during or immediately after movements, and it was only slowly regained after movement had ceased.7. The results are discussed in relation to the sliding filament theory of muscle contraction, which, with certain assumptions, provides an explanation for many of the findings.


Isotonic lengthening and shortening movements of cat soleus muscle. 1. By supplying pulses to different subdivisions of the ventral nerve roots in rotation it was possible to obtain smooth contractions of cat soleus with low rates of stimulation.2. After contracting isometrically the muscle was subjected to ;step' changes in tension after which it lengthened or shortened isotonically.3. Isotonic lengthening movements usually began relatively slowly but proceeded with increasing velocity; this acceleration was most conspicuous when low rates of stimulation were used.4. At low rates of stimulation the isotonic lengthening movement often continued beyond the length at which the muscle could have generated that tension in an isometric contraction. The muscle then shortened slowly back toward that length.5. Isotonic shortening movements began relatively rapidly, but as shortening continued the movement became slower, and often had an irregular oscillatory course.6. The isotonic movements are discussed in relation to the sliding filament theory of muscle contraction.7. The compliance of the series elastic elements was calculated from the relative amplitudes of the ;step' changes in tension and length. The stiffness of this component increased with increasing muscle tension.


The effect of membrane polarization on the time course of the end-plate current in frog sartorius muscle. 1. Intracellular recordings of the end-plate current at different membrane potentials were made, using a voltage-clamp technique.2. When the membrane potential is varied between about +40 and -120 mV, the half-decline time of the end-plate current increases from about 0.6 msec to about 1.6 msec.3. It is suggested that the stability of receptor-mediator complex is affected by the membrane potential.


The distribution of dopamine in the brain of a tortoise, Geochelone chilensis (Gray). 1. Dopamine was found in the tortoise brain; the highest concentration (3.7 mug/g) occurred in a region of the telencephalon containing the nucleus basalis and cortex olfactoria. This region may be considered similar to the mammalian and avian corpus striatum with respect to dopamine.2. The administration of reserpine or prenylamine substantially decreased the concentration of dopamine in the tortoise brain. This effect appeared later and lasted longer than in birds or mammals. When these drugs were given in doses which nearly depleted brain dopamine the characteristic signs observed in birds or mammals were not present.


Central patterning of motoneuronal activity in the cockroach.


A model of sugar movements across cell membranes.


The passage of a low molecular weight dye molecule (Patent Blue V) out of individually perfused capillaries of the frog mesentery.


Anthropometric determination of leg fat and muscle plus bone volumes in young male and female adults.


A new simple method of quantifying the electromyogram to evaluate total muscular activity.


Control circuits for stepping motor micro-electrode drive.


An electrically controlled micromanipulator using a micro-step motor.


The determination of the mechanical energy expenditure during ventricular pumping.


Measurement of instantaneous blood flow velocity in major vessels using a thin film anemometer.


Fast response recording of respiratory movements suitable for work capacity tests.


Cortical potentials evoked by pairs of peripheral stimuli.


The structure and connexions of the granule cells of the olfactory bulb: an electron microscopic study.


Proprioceptive projection areas of the cerebral cortex and their relation to cervico-lumbar spinal interactions.


Interneurone responses in the rat cuneate nucleus.


Correlation between evoked potentials and spontaneous activity in the cortex cerebri of rats.


Circadian rhythms before and after a flight from India.


Recovery of spontaneous respiration in rats following hypothermia.


The effect of raising arterial blood pressure on ventilation in man.


Measurement of pulmonary arterial distensibility in the dog.


The influence of lung volume and CO2 on breath-holding.


Cerebral pathways in reflex muscular inhibition from type J pulmonary receptors.


Ionic currents in rat ventricular heart fibres: voltage-clamp experiments using double sucrose-gap technique.


Sodium and potassium components of the membrane current in twitch skeletal muscle fibres investigated with a voltage-clamp technique.


Changes in the action potential of skeletal muscle produced by formaldehyde.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 44-1969.


The enigma of familial polycystic kidneys.


Estrogens, progestogens and breast cancer.


Evaluation of chromosomal changes.

Evaluation of chromosomal changes.


When to treat leukemia.

When to treat leukemia.


Alternate-day prednisone therapy.

Alternate-day prednisone therapy.


Respiratory complications of ataxia-telangiectasia.


Fever and hepatic blood flow.

Fever and hepatic blood flow.


Subclinical status epilepticus.

Subclinical status epilepticus.


Hazard of scalp-vein needles.

Hazard of scalp-vein needles.


Benzidine: a carcinogen.

Benzidine: a carcinogen.


Familial type IV hyperlipoproteinemia.

Familial type IV hyperlipoproteinemia.


Familial syndrome of primary testicular insufficiency with normal virilization, blindness, deafness and metabolic abnormalities.


Parse analysis: a new method for the evaluation of investigators' bibliographies.


Composition of fluid in twelve cysts of a polycystic kidney.


Triplet state de-activation rates in glasses and crystals.


Mechanism of bioluminescence, chemiluminescence and enzyme function in the oxidation of firefly luciferin.


Delayed luminescence of organic mixed crystals. IX. Amino acids and proteins.


Molecular mechanisms in photodynamic action.


Sensitized photooxygenation reactions and the role of singlet oxygen.


The nature of the triplet states of flavins: a further study.


Triplet states of some common photosensitizing dyes.


Assessing progress at Meldreth.

Assessing progress at Meldreth.


An eight year old at the Hamlet.

An eight year old at the Hamlet.


A contrast in educational needs.

A contrast in educational needs.


Comparison of school attainments.

Comparison of school attainments.


From mumming to Mount Olympus.

From mumming to Mount Olympus.


Three pupils at Lennox Castle.

Three pupils at Lennox Castle.


Detecting visual dysfunction.

Detecting visual dysfunction.


Porridge--or a pot of paint.

Porridge--or a pot of paint.


How teachers see their status.

How teachers see their status.


On the isolation of Toxoplasma gondii from human food of animal origin. Partial results in the city of São Paulo (Brazil).


International work in cardiovascular diseases. 2. Research.


Aerobic glycolysis in atherosclerosis.

Aerobic glycolysis in atherosclerosis.


Histological differentiation of gastric carcinoma compared with the structure of the mucosa.


The blood coagulation system in tetanus patients.


Cytophotometric measurements of nucleic acids in stem-cell leukemias; a trial of assessing intensity of proliferation of leukemic cells.


The influence of spontaneous regression of Crocker sarcoma on increase of antitumor immunity.


The use of thin-layer electrophoresis in starch gel for determination of alkaline phosphatase in human blood serum.


Identical syndromes of cerebral palsy in the same family.


Maple syrup urine disease. Four years' experience with dietary treatment of a case.


Haemoglobin, erythrocyres and serum iron values in normal children 3-6 years of age.


The pharmacologically active alkaloids of Strychnos icaja Baill: strychnine and a new alkaloid, 4-hydroxystrychnine.


Some factors affecting diffusion from gelatin-glycerin gels.


Studies of tocopherols and related chromanols.


Studies on local anaesthetics. XXV. Hydroxyalkylaminoacylanilines as local anaesthetics.


Ethylene oxide treatment of crude drugs. V. Formation of ethylene chlorohydrin.


Cu(II)ion promoted hydrolysis of mono-ethyl esters of aspartic- and iminodiacetic acid.


Alkaline hydrolysis of some 2-oxazolidones.


Hydrolysis of anilides. VI. Alkaline hydrolysis, aminolysis and general acid catalyzed alkaline hydrolysis of monofluoroacetanilide. Kinetic evidence for the existence of more than one intermediate in the hydrogen carbonate ion catalyzed alkaline hydrolysis.


Pharmacological and phytochemical investigations of African Strychnos species.


Hydrolysis of anilides. VII. Alkaline hydrolysis, aminolysis and general acid catalyzed alkaline hydrolysis of acetanilide. Kinetic evidence for the existence of more than one intermediate in the hydrogen carbonate ion catalyzed alkaline hydrolysis.


Hydrolysis and aminolysis of anilides and hydrolysis of barbituric acids.


An electrical method for estimation of anticonvulsant activity in mice. I. Methodological investigations.


An electrical method for estimation of anticonvulsant activity in mice. II. Application of the method in investigations of some anticonvulsant drugs.


An electrical method for estimation of analgesic activity in mice. I. Methodological investigations.


An electrical method for estimation of analgesic activity in mice. II. Application of the method in investigations of some analgesic drugs.


Studies of analgesic and anticonvulsant activity in mice by high-frequency electrical stimulation.


Some derivatives of arecaidine.

Some derivatives of arecaidine.


Some derivatives of quinuclidine-3-carboxylic acids.


Foreign particles in powder ampoules and vials.


The kinetics of hydrolysis of physostigmine salicylate.


Stability and stabilization of carbachol in aqueous solution.


A convenient method for purification of an aminopeptidase fraction, including oxytocinase (cystine aminopeptidase), from retroplacental serum.


Hydrolysis of barbituric acids. IV. Kinetic evidence for hydroxide ion-catalyzed breakdown of tetrahedral substrate-hydroxide ion complexes.


Brain and blood levels of phenobarbital-2-14C during postnatal development in the mouse.


Acetylene compounds of potential pharmacological value. 13. 2-substituted 1,3-indandiones.


Acetylene compounds of potential pharmacological value. XII. Central and peripheral anticholinergic activity of t-aminoalkynyl esters of some carboxylic acids.


Studies on local anaesthetics. XXVI. Methoxyalkylaminoacylanilines.


Studies on the medicinal chemistry of oxoquinazolines.3. 1-(omega-dimethylamino)alkyl derivatives of 3-substituted 1,2,3,4-tetrahydro-2,4-dioxoquinazolines.


Gas chromatographic determination of the secondary amine alprenolol, as its trifluoroacetyl derivative, at nanogram levels in biological fluids.


Studies on the medicinal chemistry of oxoquinazolines. II. Synthesis and local anaesthetic activity of homologous derivatives of 1,2,3,4-tetrahydro-2,4-dioxoquinazoline and 3,4-dihydro-4-oxoquinazoline.


The contamination of ampoules in connection with opening.


Constituents of the bark of Sickingia klugii (Standl).


Some 2-bromobenzyl and 2,6-dimethylphenoxyethyl substituted sterically hindered amines.


Role of catecholamines in actue myocardial infarction.


The intestinal brush border as a digestive and absorptive surface.


Localization of the renal excretion of the tritiated digoxin.


Surface sugar in the intestine.

Surface sugar in the intestine.


Absorption and excretion of two chloramphenicol products in humans after oral administration.


Diphtheria antitoxin titers in hospital workers after a single dose of adult type diphtheria tetanus toxoid.


Cervical stump cancer.

Cervical stump cancer.


Effect of bilateral excision of the round ligaments on the position of the uterus after labor.


Misdiagnosis of endometrial adenocarcinoma in young women with polycystic ovarian disease. Report of a case with an endocrine study.


Evaluation of oral progestogens for contraception in Indian women. A four-year study.


Observations on uterine growth effected by mechanical distention.


Effects of estradiol upon the thymus and lymphoid organs of immature female rats. The purpose of this study was to determine if large amounts of estrogenic hormones produced by the placenta could play a role in the development of the lymphoid tissue changes of pregnancy.  40 immature female rats were used.  The group was divided into 4 lots of 10 animals each.  The first group was castrated.  The second group was castrated and given 1.5 mg of estradiol valerianate every fifth day to a total of 4.5 mg.  The third group was castrated and injected with peanut oil only, the vehicle used for the estradiol.  The fourth, a control group, was untreated.  All animals were killed on Day 19.  Spleens, genital organs, thymus glands, and mediastinal lumph nodes were removed, weighed and prepared for histologic examination.  Thymus glands showed involution.  The genital organs were well developed in the group receiving estradiol, but showed involution in other castrated animals.  Histological examination of the thymus of animals receiving estradiol showed signs of lymphatic depletion.  Spleens, lymph nodes, and adrenals appeared normal.  It was concluded that estradiol, and possible other estrogenic hormones, might be of importance in the mechanisms of the immune response.  This could apply to the Rh immunization of the pregnant female to her fetus.


Suppression of fertility by intrauterine copper and zinc in rabbits. A new approach to intrauterine contraception.


Importance of changes in uterine blood flow in initiation of labor.


Effect of progesterone on hypertonic saline-induced abortions.


Effect of diuretic administration on urinary estriol levels in late pregnancy.


Effect of pregnancy on the human aorta and its relationship to dissecting aneurysms.


Erythrocyte metabolism in pregnancy complicated by idiopathic jaundice.


Some aspects of blood lactate levels in mother and fetus.


The young unwed mother. Obstetric results of a program of comprehensive care.


Fetal compromise during elective cesarean section. II. A report from the Colloborative Project.


Detection of fetal heart sounds. An analysis.


Perinatal mortality associated with cesarean section.


Diameters of umbilical cord vessels and the weight of the cord in relation to clamping time.


Smooth muscle in the human placenta.

Smooth muscle in the human placenta.


Validity of scalp blood sampling. Comparison of scalp and arterial blood in the newborn.


Clinical significance of correlation between size of uterine cavity and IUCD. A study by planimeter-hysterogram technique.


Sterilization by tubal cauterization and transection at laparoscopy.


Monoamniotic twins with a common umbilical cord.


Serum copper levels as a measure of placental function.


Couvelaire uterus and placenta previa.

Couvelaire uterus and placenta previa.


Symptomatic myoma in a 13-year-old girl.


Successful pregnancy following ureteroileostomy.


Metastasis of maternal cancer to placenta and fetus.


Plasma zinc and copper levels.

Plasma zinc and copper levels.


Pulmonary collateral circulation in canine dirofilariasis.


Aflatoxicosis in dogs.

Aflatoxicosis in dogs.


Nationally speaking.

Nationally speaking.


Phenotypic comparison of Brucella ovis to the DNA-homologous Brucella species.


Effect of motor cortex ablation on conditioned learning in sheep.


Hemoglobin types and resistance to Haemonchus contortus in sheep.


Control of gamma efferents through the reticular activating system.


Prototheca, a cause of bovine mastitis.

Prototheca, a cause of bovine mastitis.


A customized crutch hand grip.

A customized crutch hand grip.


A preliminary study. Assessment of perceptual development.


Erythrocytic enzyme activity, ion concentrations, osmotic fragility, and glutathione stability in bovine erythropoietic porphyria and its carrier state.


Effect of ascorbic acid on copper deficiency in miniature swine.


Electron microscopy of nongranular leukocytes and thrombocytes of chickens.


Electron microscopic study of Anaplasma ovis.


Efficacy of parbendazole against gastrointestinal nematodes in goats.


Treatment of pathological distortion of body image.


A technique for fabricating and fitting a pre-prosthetic training arm.


The occupational therapist as consultant.


Portable egg candling booth.

Portable egg candling booth.


The role of occupational therapy in a children's inpatient psychiatric unit.


Natural history and management of chronic rheumatic endocarditis.


Cardiac lesions in children with "hypercalcaemic" facies.


Pharmacological fibrinolysis.

Pharmacological fibrinolysis.


Arthritis and the heart.

Arthritis and the heart.


Claudication.

Claudication.


Lipoprotein deficiency disorders.

Lipoprotein deficiency disorders.


Fingerprints in congenital heart disease.


Home care of myocardial infarction.

Home care of myocardial infarction.


Aortic valve replacement: a follow-up.

Aortic valve replacement: a follow-up.


The evaluation of clinical phenomena in psychiatry.


Drugs and liver disease.

Drugs and liver disease.


Pseudo-obstruction of the small bowel.

Pseudo-obstruction of the small bowel.


Atrial bradycardia or the lazy sinus syndrome.


The effects of iproniazid and reserpine on the accumulation of granular vesicles and noradrenaline in constricted adrenergic nerves. 1. The accumulation of granular vesicles proximal to a constriction applied to hypogastric nerves has been investigated with the electron microscope in cats treated with reserpine and/or iproniazid.2. The ultrastructural changes have been correlated with the accumulation of noradrenaline at the same site in similarly treated animals.3. The findings give further support to the view that granular vesicles constitute a major storage site for intraneuronal noradrenaline.


The strychnine-like action of curare and related compounds on the somatosensory evoked response of the rat cortex. 1. Drugs were applied to the cerebral cortex of rats anaesthetized with pentobarbitone and changes measured in the somatosensory primary evoked response.2. Computer-derived averages of thirty-two consecutive responses yielded stable and consistent measurements of the potential changes comprising the evoked response, and comparable records from the opposite (non-drug treated) cortex provided an essential control for systemic actions of the drug.3. The modifications produced by curare and strychnine were indistinguishable. The first positive wave (peak latency 7 msec) was unaltered; the second positive wave (peak latency 11.5 msec) was variably enhanced, and the first and second negative waves (peak latencies 16 and 40 msec) were replaced by a much larger negative wave (peak latency 22 msec).4. The time of onset of the effect on the negative waves and the maximal amplitude attained by the abnormal negative wave were related to the log concentration of the drug used. Curare is approximately 10 times more potent than strychnine.5. Toxiferine I, di-allylnortoxiferine and atropine also produced this effect but were less potent than strychnine.6. Succinylcholine, dihydro-beta-erythroidine and gallamine triethiodide did not produce this effect (in concentrations up to 10(-3)M).7. The observations are consistent with an action of curare and strychnine on an intracortical cholinergic inhibitory system, but other possibilities including a "non-specific excitatory action" cannot be excluded.


Antagonism by physostigmine of the "running fit" caused by levorphanol, a morphine congener, in mice. 1. Drugs of the morphine type cause a stereotyped "running fit" in the mouse.2. The intensity and duration of this response are related to the dose.3. Measurement of this phenomenon serves as a good method for the quantitative comparison of drugs of this type and for the study of their antagonists.4. Intracerebral injection of physostigmine antagonized the "running fit" induced by a wide range of doses of levorphanol.5. The results are consistent with the hypothesis that drugs of the morphine type act by retarding the release of acetylcholine at some central cholinergic synapses.


A sequential screning test based on the running component of audiogenic seizures in mice, including reference compound PD50 values. 1. The running component of audiogenic seizures in mice has been used as the basis of a sequential screening test for the detection of a variety of centrally acting drugs.2. For acceptance by the test, an active compound must completely suppress the running component in a total of sixteen mice at a dose of 1/5 LD50 intraperitoneally.3. Considerable economies in the numbers of animals required for screening have been achieved, the mean number of mice required to reject an inactive compound being 2.0.4. The running component is highly sensitive to anticonvulsants and general central depressants, and insensitive to phenothiazine tranquillizers and morphine. Reserpine caused an increase in the severity of the running component.5. The statistical model used in this test is of general application to screening test situations which use quantal data.


Structure and pharmacological actions of phyllocaerulein, a caerulein-like nonapeptide: its occurrence in extracts of the skin of Phyllomedusa sauvagei and related Phyllomedusa species. 1. The South American amphibian Phyllomedusa sauvagei contains in its skin large amounts of a polypeptide closely resembling caerulein in its pharmacological actions. This polypeptide, called phyllocaerulein, was obtained in a pure form, and upon acid hydrolysis, enzymic digestion and end-group determination experiments it proved to be a nonapeptide of the following composition Pyr-Glu-Tyr(SO(3)H)-Thr-Gly-Trp-Met-Asp-Phe-NH(2)It may be seen that caerulein and phyllocaerulein have in common the C-terminal heptapeptide and the N-terminal pyroglutamyl residue.2. Phyllocaerulein is indistinguishable from caerulein even in parallel bioassay. However, the former polypeptide seems to be somewhat more potent than the latter on all the preparations tested.3. In different batches of Phyllomedusa sauvagei skin the phyllocaerulein content ranged between 150 and 600 mug/g of fresh tissue.Phyllocaerulein or similar polypeptides occur also in the skin of several other Phyllomedusa species, among which are Phyll. burmeisteri, Phyll. dachnicolor, Phyll, helenae, Phyll. annae, Phyll. callidryas and Phyll. bicolor.4. The qualitative identification and quantitative estimation of caerulein-like polypeptides in crude skin extracts may be complicated by the concomitant occurrence of other active polypeptides. These, however, are poorly effective on some test preparations which seem to respond selectively to caerulein.5. Like that of caerulein, the biological significance of phyllocaerulein is completely obscure.


The action of caerulein on pancreatic secretion of the dog and biliary secretion of the dog and the rat. 1. Caerulein displayed a potent stimulant action on pancreatic secretion in the dog. Threshold doses were 1-5 ng/kg by rapid intravenous injection, 0.25-1 ng/kg per min by intravenous infusion and 50-100 ng/kg by subcutaneous injection. There was a conspicuous increase not only in the volume flow of pancreatic juice but also in the output of solid constituents of the juice and of amylase. However, continuous stimulation of pancreatic secretion by intravenous infusion of caerulein resulted in a progressive reduction of the amylase concentration and still more of the dry residue content of pancreatic juice. The bicarbonate concentration in pancreatic juice produced by caerulein was similar to that observed in juice secreted following pancreozymin administration or following other stimuli causing the same rate of flow of pancreatic juice.2. On a molar basis, caerulein was 25-30 times as active as human gastrin I and 3-6 times as active as cholecystokinin-pancreozymin. The presence in the molecule of caerulein of a sulphated tyrosyl residue at position 4 of the decapeptide (position 7 starting from the C-terminus) was a necessary prerequisite for the manifestation of the cholecystokinin-pancreozymin-like actions of caerulein. The C-terminal heptapeptide of caerulein retained much of the activity of the intact caerulein molecule.3. At high dose levels (50-200 ng/kg in the dog, 1 mug/kg in the rat, by rapid intravenous injection) caerulein stimulated the flow of hepatic bile in the dog and the rat. The dry residue of the bile and the cholesterol concentration were appreciably greater in rats treated with caerulein than in control rats.4. The activity spectrum of caerulein was identical with that of cholecystokinin-pancreozymin. This is readily explained on the basis of the almost identical structure of the C-terminal octapeptide of the two peptides.5. Caerulein and some caerulein-like peptides may be considered as model peptides, capable of being substituted for cholecystokinin-pancreozymin in all the possible experimental and clinical uses of the duodenal hormone, with the important advantage that they are more easily available.6. The question is raised whether cholecystokinin-pancreozymin obtained from the duodenum by acid extraction is the authentic hormone or rather a carrier polypeptide from which a smaller active peptide may be set free, when needed, into the circulation.


Existential phenomenology and the sociological tradition.


Histochemical fluorescence studies on noradrenaline accumulation by Uptake 2 in the isolated rat heart. 1. The distribution of noradrenaline accumulated by Uptake(2) (Iversen, 1965) in the isolated perfused rat heart has been observed using histochemical fluorescence microscopy.2. On the basis of the technique used, noradrenaline seems to be predominantly associated with the cardiac muscle cells, but sympathetic nerves and other cardiac structures also serve as retention sites.3. Phenoxybenzamine, normetanephrine and perfusion with noradrenaline at 20 degrees C all decreased noradrenaline accumulation.4. Lowered temperature significantly increased the perfusion pressure and significantly decreased the [(14)C]-sorbitol space in perfused hearts.5. The implications of these results are discussed.


Dual leadership in complex organizations.


Demotion in industrial management.

Demotion in industrial management.


Scientists at major and minor universities: a study of productivity and recognition.


Career anchorage: managerial mobility motivations.


Social class and premarital sexual permissiveness: a re-examination.


A comment on "anomy".

A comment on "anomy".


A factor analytic exploration of the alienation, anomia and authoritarianism domain.


Technical note on two rates of mixed marriage.


Some comments on awareness.

Some comments on awareness.


On experimental design.

On experimental design.


Potential ethological isolating mechanisms and assortative mating in the domestic fowl.


The comfort movements of Anatidae.

The comfort movements of Anatidae.


An experimental study of conflict and fear: an analysis of behavior of young chicks toward a mealworm. I. The behavior of chicks which do not eat the mealworm.


Observations on the incidence of following of visual and auditory stimuli in naive mallard ducklings (Anas platyrhynchos).


The transport of prey by ants.

The transport of prey by ants.


The measuring function of the first legs of Araneus diadematus Cl.


Courtship behaviour in the Drosophila obscura group. II. Comparative studies.


Pain and the psychiatrist.

Pain and the psychiatrist.


On the genesis of male homosexuality: an attempt at clarifying the role of the parents.


On the genesis of female homosexuality.

On the genesis of female homosexuality.


Conceptual thinking in schizophrenics and their relatives.


A psychosomatic study of writer's cramp.


Psychotherapy of a shared syndrome in identical twins.


Delinquency and the amphetamines.

Delinquency and the amphetamines.


Vision versus touch in form discrimination.


Short-term retention as a function of method of measurement, recording time, and meaningfulness of the material.


The conservation of a shape property and a proposal about the origin of the conservations.


Persisting odours as a biasing factor in open-field research with mice.


Vividness of words and learning to learn in free-recall learning.


The display of information and the judgment of contingency.


Amylase production by Streptomyces species.


Physico-chemical studies on the stability of penicillin salts. IV. A statistical evaluation.


Studies on nitrogen metabolism of Penicillium chrysogenum Thom. I. Effects of lactose and sucrose additions on nitrogen metabolism.


Studies on nitrogen metabolism of Penicillium chrysogenum Thom. II. Amino acid metabolism and its relation to the biosynthesis of penicillin.


The contribution of thoracic surgery to our discipline.


Research past and present, with particular reference to the application of the techniques of basic science to the problems of adrenal pathology.


Some inflammatory disorders of the large intestine.


Coexistence of subdural and archnoidal collections of fluid: an unusual case.


The scope of sphincterotomy in biliary and pancreatic surgery.


Sarcoidosis involving the veriform appendix.


Control of post-haemorrhoidectomy bleeding with a Foley catheter and a pack.


"Chronic pancreatitis" and carcinoma of the pancreas. A method to aid correct diagnosis.


Diagnostic evaluation of the patient with high blood pressure.


Renal vascular hypertension; diagnosis and treatment.


Epidemiology of hypertension.

Epidemiology of hypertension.


The angiogram in the study of hypertension.


The use of radioactive isotopes in the diagnosis of hypertension.


Hepatocerebral degeneration (portal systemic encephalopathy). The relationship to fatty acids.


Relation between release of free fatty acid from the adipose tissue and carbon tetrachloride-induced fatty infiltration in the liver.


The role of the hormonal glands and sympathetic nerve in the fatty infiltration of liver resulting from carbon tetrachloride toxicity.


A general method for the determination of organophosphorus pesticide residues in foodstuffs.


A case of adenocarcinoma of the lung, accompanied by congenital lung cysts.


Chromosomes of human tumors. VI. A comparative chromosome survey of the primary and its secondary tumors.


A simple concentration-cell technique for determining small amounts of  halide ions and its use in the determination of residues of organochlorine pesticides.


Determination of chloride in beer by radioactivation analysis.


The detection and estimation of  aflatoxin in groundnuts and groundnut materials. IV. Routine assessment of toxicity due to aflatoxin B1.


Effects of large doses of androgen on rodent erythropoiesis and body composition.


Heinz body anemia: an ultrastructural study. II. Red cell sequestration and destruction.


Alkaline phosphatase in neutrophil leukocytes of patients with infectious mononucleosis and the effect of corticosteroid therapy.


Treatment of chronic ulcerative colitis.


The activation of factor 8 by thrombin.

The activation of factor 8 by thrombin.


Conduction time and velocity in human recurrent laryngeal nerve.


A case of neonatal meningitis caused by a yellow enterobacter.


Treatment of climacteric symptoms.

Treatment of climacteric symptoms.


The effect of psychotropic drugs on gonadotrophin excretion in man.


Antibiotics for the skin, with and without corticosteroids.


The angle of gait.

The angle of gait.


Local infiltration and regional nerve block anesthesia in pedal surgery.


Phenol-alcohol nail procedure: postoperative care. A comparative study.


The Babinski sign.

The Babinski sign.


Decubitus ulcers in a geriatric institution.


Heel apophysitis. Three case reports.

Heel apophysitis. Three case reports.


Leather insoles for basketball players.

Leather insoles for basketball players.


A study of item weights and scale lengths for the SVIB.


Refractory eosinophilia in children.

Refractory eosinophilia in children.


Intravenous iron therapy in large dosage.


Meningitis due to Haemophilus Influenza.


Augmented histamine test in peptic ulcer and acid dyspepsia.


Clinical trial of Quinethazone--Reserpine (diuretic cum antihypertensive--drug).


Recalcitrant eosinophilosis in children.


Primary pulmonary hypertension: clinical and hemodynamic study of three cases.


Observation on Thiabendazole in anklyostomiasis.


Management of acute barbiturate poisoning, supportive therapy and artificial kidney.


Energy deployment and achievement.

Energy deployment and achievement.


Three processes of dying and their behavioral effects.


Constancy of psychotic syndromes in men and women.


Relationship between institutionalization, other demographic variables, and the structure of intelligence in chronic schizophrenics.


Structure of psychotherapy: role playing as a variable in dyadic communication.


Sampling from the recorded therapy interview: the problem of segment location.


Performance of different diagnostic groups on the tachistoscopic and copy phases of the Bender-Gestalt.


Factorial structure and prognostic significance of premorbid adjustment in schizophrenia.


"Validity" of short-form intelligence tests.


Daydreaming frequency and some personality measures.


Academic and nonacademic accomplishment: correlated or uncorrelated?


Structure of motivations for becoming a teacher.


Discrimination of verbal material as a function of  intrapair similarity in deaf and hearing subjects.


Language aptitude, intelligence, and second-language  achievement.


Inhibitory potential in good and poor achievers.


Memory and the feeling-of-knowing experience.


Word relatedness and problem solving in high-school physics.


A dual peripheral and supraspinal autonomic influence on the urinary bladder. A survey of previous and new concepts based on experimental results.


Intraperitoneal nebacetin-hydrocortisone in acute peritonitis caused by appendicitis. A controlled clinical trial.


A clinical sciences institute.

A clinical sciences institute.


Incidence of mental disorders in Victoria, Australia, according to country of birth.


Factors influencing the incidence of mental disorders among migrants.


Previous history of mental illness in female migrant patients admitted to the Psychiatric Hospital, Royal Park.


Oral contraceptives.

Oral contraceptives.


Clinical experiences with enibomal, a short-acting barbiturate for intravenous anaesthesia.


Fluid and electrolyte balance in surgical patients. I.


Frozen blood; a review of principles and techniques and N.D.M.C. progress notes.


Incidence of suicide among the ethnic groups of the Northwest Territories and Yukon Territory.


Developmental and situational problems of the psychiatric service in a general hospital.


A comparison of questionnaire to physical examination in assessing the health of 67 individuals at RCAF Greenwood.


Acute haemorrhagic pancreatitis. A case presentation.


National Health Grants, 1948-1961. XX. Professional training.


Mass spectra of hasubanonine, metaphanine and their derivatives.


Drugs and blood dyscrasias.

Drugs and blood dyscrasias.


A total synthesis of the stereoisomeric mixture of magnolamine.


Gastrojejunocolic fistula.

Gastrojejunocolic fistula.


Regional enteritis.

Regional enteritis.


Attempted suicide by chemical agents.

Attempted suicide by chemical agents.


The effect of orally ingested cerebroside on the excretion of coprostanol in cholesterol-fed rats.


Artificial drainage tubes for glaucoma.

Artificial drainage tubes for glaucoma.


Influence of small systematic errors on the results of tonometric screening.


Surgical parameters in idiopathic ulcerative colitis.


Parotidectomy for chronic parotitis.

Parotidectomy for chronic parotitis.


Glaucoma following ligation of the superior vena cava.


Primary angle-closure glaucoma. Investigations using 10 per cent phenylephrine eyedrops.


Cardiac arrest occurring in a patient on echothiophate iodide therapy.


Bifoveal instability. The relationship to strabismic amblyopia.


Surgical results in esotropia associated with myopia.


Superficial corneal foreign bodies of organic origin.


Plasma seromucoid levels in uveitis.

Plasma seromucoid levels in uveitis.


Treatment of advancing enophthalmos in the ocular prosthetic patient: A preliminary report including a warning.


A discussion of acoustic artifacts in ophthalmic ultrasonography.


Histoplasmosis. The relation between skin test and latex-agglutination antibodies.


Diagnosis of intraocular tumors with special reference to binocular indirect ophthalmoscopy.


Electric rust-ring remover technique.

Electric rust-ring remover technique.


Flash blindness.

Flash blindness.


Vital staining in normal eyes and in keratoconjunctivitis sicca.


Instrument for conjugate ophthalmodynamometry.


Treatment of palpebral warts with cantharon.


Therapy and staging in advanced cancer of the maxillary antrum.


Multiple mouth-throat cancer.

Multiple mouth-throat cancer.


Multiple malignancies in patients with head and neck cancer.


Use of muscle flaps for reconstruction after head and neck surgery for cancer.


Irradiation in the management of tumours of the head and neck.


Carcinoma of the lip. A comparison of five year results after irradiation and surgical therapy.


Paralimbal ring keratitis and absence of lysozyme.


Preoperative versus postoperative radiation in the treatment of squamous carcinoma of the paranasal sinuses.


A comparison of wound healing between irradiated and nonirradiated patients after radical neck dissection.


The cerosium mandibular prosthesis.

The cerosium mandibular prosthesis.


The function of the dental specialist in the treatment of cancer of the head and neck.


Embryonal rhabdomyosarcoma of the head and neck. Report on eighty-eight cases.


Metastatic basal cell carcinoma.

Metastatic basal cell carcinoma.


Branchiogenic cysts: congenital or acquired.


Temporalis transfer for lagopthalmos due to seventh nerve palsy.


An evaluation of treatment of cancer of the larynx.


Surgical approach to intraoral neoplasms without division of lip.


Spontaneous carotid artery hemorrhage after head and neck surgery.


Use of intravenous diazepam in acute skeletal muscle spasm. Preliminary report.


Spindle and giant cell metaplasia in papillary carcinoma of the thyroid.


Skeletal muscle spasm and some speculations on the mode of action of diazepam.


Use of diazepam for the relief of spasticity in multiple sclerosis.


The use of diazepam in the treatment of musculo-skeletal disorders.


Diazepam in the relief of muscle spasm resulting from spinal-cord lesions.


Rheumatic fever and rheumatic heart disease in children below the age of 5 years in the tropics.


Culture of synovial cells in vitro. Notes on isolation and propagation.


Choices in psychotherapy research.

Choices in psychotherapy research.


ABO blood groups and rheumatic heart disease.


Beta-haemolytic streptococci and antistreptolysin-O titres in patients with rheumatoid arthritis and a matched control group.


Practical problems in the assessment of personality in the clinical field.


Permissiveness.

Permissiveness.


Sparing effect of neurological deficit and trauma on the course of adjuvant arthritis in the rat.


Body image and susceptibility to contact dermatitis.


Influence of non-uniformity of the lungs on measurement of pulmonary diffusing capacity.


The relationship of obsessional traits to general emotional instability.


Hypnosis in "psychosomatic" illness.

Hypnosis in "psychosomatic" illness.


Cystine metabolism in cystinuria.

Cystine metabolism in cystinuria.


A micropuncture study of renal bicarbonate and chloride reabsorption in hypokalaemic alkalosis.


The effect of unilateral pulmonary artery occlusion on renal function in subjects with chronic pulmonary disease.


Lipid composition of human psoas muscle.


The measurement of regional cerebral clearance rates in man using xenon-133 inhalation and extracranial recording.


Body weight in older people.

Body weight in older people.


The measurement of oscillatory blood flow and impedance in the human external iliac artery.


The effects of various dietary carbohydrates on the serum lipids during a five-day regimen.


Quality control of radioactivity-counting systems.


The effects of aldosterone and glucocorticoid on free water reabsorption.


Protein and amino acid metabolism in kwashiorkor.


Peripheral and portal vein blood sugar after lactose and galactose feedings.


Phosphate metabolism in patients with renal calculus.


What is O.R. nursing? Who should do it?

What is O.R. nursing? Who should do it?


Lung function after pneumonectomy in man.


Challenge of central service in the small hospital.


Surgery check list saves many hours of personnel time.


Some overtones of euthanasia.

Some overtones of euthanasia.


Small hospitals utilize computers-at a savings.


First podiatry hospital in U.S. is clinical-educational resource.


Outpatient care--major service of the future.


Outpatient care--the role of the emergency department.


Housekeeping services.

Housekeeping services.


Review of hospital lawsuits.

Review of hospital lawsuits.


Interning in public relations.

Interning in public relations.


The effect of disposables on the roles of the pharmacist and nurse.


I am a pharmacist.

I am a pharmacist.


Professional solicitation.

Professional solicitation.


Homeostasis: a study in carbohydrate metabolism.


Here are 66 ways hospitals cut expense.

Here are 66 ways hospitals cut expense.


Has your public relations kept pace with your other progress?


Work analysis cut payroll 14 per cent.

Work analysis cut payroll 14 per cent.


This flexible staffing plan puts nurses in right place at right time.


Minnesota hospitals, Blue Cross plan cooperative data processing.


Supervisors' homework: controlling costs.


The hospital of the month. It costs more but patients are delighted.


Why St. Louis hospitals buy together.

Why St. Louis hospitals buy together.


How is inventory value reconciled between physical count and report?


Why hospital reduced lab fees 50,000 dollars.


California decision shows trend to specialty staff requirements.


What equipment and services are vital to preventive maintenance?


Payroll, inventory and purchasing are targets for pharmacy saving.


Here is nurses' guide to help reduce costs.


This dietary cuts cans to control costs.


What hospitals do to cut their housekeeping costs.


Maryland trains employes to keep them.

Maryland trains employes to keep them.


How government will enforce Rights Act.

How government will enforce Rights Act.


How industrial engineer aids purchasing.


Finding your rates of absenteeism is first step to program of control.


Immunology now--an explanation.

Immunology now--an explanation.


The megaloblastic anaemias.

The megaloblastic anaemias.


Ham Green Hospital, Bristol.

Ham Green Hospital, Bristol.


Hookworm anaemia.

Hookworm anaemia.


A prototype drugs and lotions cabinet.

A prototype drugs and lotions cabinet.


The Hawthorne experiments.

The Hawthorne experiments.


Otoscopic examination and other aural tests.


Nurse planners meet.

Nurse planners meet.


Why I am a nurse.

Why I am a nurse.


Staff ward meeting.

Staff ward meeting.


Medication before and after operation.

Medication before and after operation.


Planning competition--ward design.

Planning competition--ward design.


Ward plan for a new hospital.

Ward plan for a new hospital.


The planning process.

The planning process.


Hospital internal communications. Sickness patterns of nursing staff.


Splenosis. Report of a case.

Splenosis. Report of a case.


Complete form of testicular feminization syndrome. Report of a case with biochemical and psychiatric studies.


Endometriosis of the pleura.

Endometriosis of the pleura.


Behcet's syndrome. Report of a case and review of the literature.


Serious bleeding following vaginal or abdominal hysterectomy.


R. I. P.

R. I. P.


Measles immunization.

Measles immunization.


Smallpox immunization.

Smallpox immunization.


Diphtheria immunization.

Diphtheria immunization.


Pertussis immunization.

Pertussis immunization.


Tetanus immunization.

Tetanus immunization.


Poliomyelitis immunization.

Poliomyelitis immunization.


Combined prophylaxis.

Combined prophylaxis.


Consultation or second opinion.

Consultation or second opinion.


Typhoid immunization.

Typhoid immunization.


The surgery of otosclerosis. A review of five hundred cases of stapedectomy.


Palindromic rheumatism treated with indomethacin.


Chemical tests for alcoholic intoxication.


The effects of abolishing prescription charges. A study from general practice.


A case of varicella encephalitis.

A case of varicella encephalitis.


The care of the skin around an ileostomy.


Current therapeutics. 213. Desferrioxamine.


Physical medicine. IX. Hydrotherapy.

Physical medicine. IX. Hydrotherapy.


The management of respiratory and cardiac emergencies.


Commentary on common alimentary symptoms.


Radiotherapy.

Radiotherapy.


Bronchial carcinoma.

Bronchial carcinoma.


Bronchial carcinoma air pollution, smoking and lung cancer.


Industrial poisons in town and country.

Industrial poisons in town and country.


Poisons in the country.

Poisons in the country.


Second thoughts on steroids.

Second thoughts on steroids.


Crohn's disease.

Crohn's disease.


Malignant melanoma.

Malignant melanoma.


Analytic tuberculology-resolution of human tuberculosis problems.


Hematologic studies in undernourished children with low serum vitamin E levels.


Plasma amino acids and the detection of protein-calorie malnutrition.


Some further observations on goiter in Lebanon.


Composition of human adipose tissue, with special reference to site and age differences.


Human milk lipids. II. The influence of dietary carbohydrates and fat on the fatty acids of mature milk. A study in four ethnic groups.


Human milk lipids. 3. Short-term effects of dietary carbohydrate and fat.


Conceptual and cognitive psychiatry.

Conceptual and cognitive psychiatry.


The sciences of psychiatry: fields, fences and riders.


Dreaming sleep in autistic and schizophrenic children.


The reaches of intrapsychic conflict.

The reaches of intrapsychic conflict.


Alcoholism, parole observations and criminal recidivism: a study of 116 parolees.


Hand morphology in some severely impaired schizophrenic children.


Observations on children who have been physically abused and their parents.


Self-pity.

Self-pity.


Information explosion--information retrieval.


Sodium amytal, hypnosis and psychotherapy.


Haloperidol--a preliminary clinical study.


The use and effectiveness of electrosleep in the treatment of some common psychiatric problems.


Beyond the unconscious: the ultraconscious.


Recent research in molecular biology: introduction.


Management of bronchiolitis.

Management of bronchiolitis.


Cancer in East Africa.

Cancer in East Africa.


Vaccine against anthrax.

Vaccine against anthrax.


Vision and the cerebral hemispheres.

Vision and the cerebral hemispheres.


Ethacrynic acid: two years' experience with a new diuretic.


Primary volvulus of small intestine.

Primary volvulus of small intestine.


Acute pyogenic meningitis probably due to Acanthamoeba sp.: a preliminary report.


World Medical Association. Presidential address.


Safety of oral contraceptives.

Safety of oral contraceptives.


Sequelae of thorotrast.

Sequelae of thorotrast.


Phenylbutazone.

Phenylbutazone.


Disorders of the knee in miners.

Disorders of the knee in miners.


Coarctation of thoracic aorta, with thrombosis of arch, treated by homograft.


Do psyhiatric out-patients take their drugs?


Phenylbutazone-induced pericarditis.

Phenylbutazone-induced pericarditis.


A training prosthesis for upper-limb amputees.


World Medical Association: nineteenth general assembly.


An evaluation of popular nutritional knowledge.


The role of chemistry in pest control.

The role of chemistry in pest control.


Dehydration of food.

Dehydration of food.


Alkylation of 1,2,6-thiadiazine 1,1-dioxides.


Heart muscle nuclei: preparation and some properties.


Cinearteriographic evaluation of free omental grafts to the myocardium.


A-V conduction and other parameters of the respiratory-heart rate response.


The influence of local atropinization of the A-V node on retrograde V-A conduction.


Viral myocarditis.

Viral myocarditis.


Lymphocyte transformation in epithelium.


Tissue and cellular distribution of tritum-labeled AET in mice.


Growth and behavior of cultured human epidermal cells implanted in homologous skin.


Marathoner DeMar: physiological studies.


Study of metastasis after the intravenous injection of ascites carcinoma number 678 into C3H mice at high altitude.


On scientific attitudes.

On scientific attitudes.


The spectrum of neurogenic tumors of the sympathetic nervous system: maturation and adrenergic function.


Microscopical diagnosis of olfactory esthesioneuromas: general review and report of five cases.


The problems of osteomyelitis in childhood.


The presentation and surgical implications of complete heart block.


Suicide and attempted suicide in north-eastern Tasmania.


Primary hypopituitary dwarfism with Fanconi's hypoplastic anaemia syndrome, renal hypertension and phycomycosis: report of a case.


Adrenal haematoma in a new-born infant simulating renal tumour.


Partial anesthesia of the scalp following general anesthesia.


Segmental renal artery stenosis with hypertension in childhood.


Shock and haemorrhage.

Shock and haemorrhage.


Subacute pancreatitis.

Subacute pancreatitis.


The management of nasal deformities associated with cleft lips.


Surgical procedure for correction of protruding ears.


The functional anatomy of the base of the heart.


Stress incontinence; complications and sequelae of the Marshall-Marchetti operation.


Post-intubation sore throat. A new aspect.


Cancer in Indonesia.

Cancer in Indonesia.


ABO iso-immunization in the Chinese; an analysis of 137 cord blood specimens.


Unexplained spastic myelopathy. 41 cases in a non-European hospital.


Unusual radiographic findings in bone tumors.


Osteotomy of the spine for fixed flexion deformity.


On efficiency in the operating room.

On efficiency in the operating room.


Induced abortion: clinical and laboratory evaluation.


Department of non-specific treatment.

Department of non-specific treatment.


Into-talus tendon transplantation.

Into-talus tendon transplantation.


Differentiation of Psteurella haemolytica and Pasteurella multocida (Pasteurella septica).


B.V.A. evidence to the Brambell Committee.


Wrongful death.

Wrongful death.


Hypercubic designs.

Hypercubic designs.


Investigation of the possibility of the presence of aflatoxin in meat and liver of chickens fed toxic groundnut meal.


Effect of mitomycin-C upon gastric cancer (from follow-up study of gastrectomy). II.


The effects of continuous estrogen administration to the female rat, started at various ages, on its pituitary.


Juvenile muscular atrophy of unilateral upper extremity.


Studies on blood of burned body. I. Resistance of carboxy-haemoglobin against heat and detection of it from thermo-coagulated blood.


Disease transmission by aircraft.

Disease transmission by aircraft.


A synthesis of chromose D (3-O-acetyl-2,6-dideoxy-D-lyxo-hexose).


Structures of ormosinine and panamine.

Structures of ormosinine and panamine.


Fischer indole synthesis and ethylation of 2,3-disubstituted indoles with polyphosphate esters.


Studies on isolation, characterisation and recovery of pectin from purple passion fruit waste (rind).


Identification of salicylic and isovanillic acids in cigarette smoke.


Popliteal artery arteriosclerotic aneurysm.


Surgical management of popliteal aneurysms.


The effect of digoxin in the splanchnic circulation in ventricular failure.


Calcification of the carotid siphon.

Calcification of the carotid siphon.


Effects of changing heart rate in man by electrical stimulation of the right atrium. studies at rest, during exercise, and with isoproterenol.


Medical and surgical care of stroke. Roentgenologic aspects.


Bidirectional shunting in a coronary artery-right ventricular fistula associated with pulmonary atresia and an intact ventricular septum.


Coincidence of mycotic (Histoplasma capsulatum) vegetative endocarditis of the mitral valve and the Lutembacher syndrome. Report of a case.


Red blood cell survival in patients with aortic valvular disease and ball-valve prostheses.


Cardiac perforation following left ventricular cineangiocardiography.


Jones criteria (revised) for guidance in the diagnosis of rheumatic fever.


Cardiovascular aspects of the Ehlers-Danlos syndrome. Report of a case with pulmonary artery bifidity and aortic arch anomaly.


Exercise graded by heart rate in electrocardiographic testing for angina pectoris.


The incidence and management of "medical" complications following cardiac operations.


Kinetocardiographic changes in ischemic heart disease.


Syphilis control. Effect of serologic reactors reports.


Mission to Panama.

Mission to Panama.


Nursing homes--past, present, future.

Nursing homes--past, present, future.


Changes in the hospital and medical facilities program.


The role of the dentist in oral cancer detection.


Safety in the chemical laboratory. XIX. Laboratory design considerations. II.


Neurosurgical evaluation of ultrasonic encephalograph.


Color scintiencephaloscanning.

Color scintiencephaloscanning.


The physiology of tremorine-induced tremor.


Subdural hematoma of the posterior fossa. Review of the literature with addition of three cases.


Surgical treatment of sacral and presacral tumors other than sacrococcygeal chordoma.


Post-traumatic abscess of the medulla oblongata containing Nocardia asteroides.


Scanning with positron-emitting radioisotopes: aneurysm, arteriovenous malformation and intracerebral hemorrhage.


Endocardial fibroelastosis.

Endocardial fibroelastosis.


Needle with fixation system for permanent-pressure measurement.


Diagnostic value of bromsulphalein test in hepatic cirrhosis.


Affective disorder: VI. A family history study of prevalences, sex differences and possible genetic factors.


Psychopathology and 5-hydroxyindoleacetic acid excretion.


A study of ventilatory functions in healthy Indian adults.


The relationship of glucagon and EEG patterns in hypoglycemia.


Respiration and mental activity in sleep.


Puromycin inhibition of ethanol ingestion and liver alcohol dehydrogenase activity in the rat.


Hodgkin's disease of the stomach; a case report.


Hydatid disease of the spine. A case report.


Reciprocal inhibition: inapplicability to tendon jerks.


Electron-microscope study of the effect of increased intracranial pressure on the arachnoid villus.


Temporary cardiac arrest for the coronary arteriography and the thoracic aortography.


On the influence of the administration of aromatic compounds upon the distribution of porphyrin bodies in tissues. IV. The effect of p-aminobenzoic and 5-hydroxyanthranilic acids.


Electron microscopic observations of the splenic red pulp with special reference to the pitting function.


Polarographic studies on proteins and enzymes. II. The polarographic catalytic wave of proteins in tris(ethylenediamine)cobalt(3) chloride solution.


On the mechanism of diarrhea due to folium sennae.


The effect of Mannitol on the kidney in trauma and shock.


The relation of "hypercoagulability" to thrombosis.


Hyperlysinemia associated with retardation.


Dextran therapy of purpura fulminans.

Dextran therapy of purpura fulminans.


Isolation of Coxsackie virus group A, type 4, from a patient with hemolytic-uremic syndrome.


The management of leprosy and its complications.


Case records of the Massachusetts General Hospital. Case 43-1965.


Problems in medical education.

Problems in medical education.


The limits of over-constancy.

The limits of over-constancy.


Physical growth in mental defectives. A study in an institutionalized population.


Binocular rivalry and the contrast at contours.


The nature of the age decrement in performance on dichotic listening tasks.


Similarity and intrusions in short-term memory for consonant-vowel digrams.


Length of experimental session as a parameter of response rate under a non-discriminated avoidance schedule.


Position reversal training in the Virginia opossum: evidence for the acquisition of a learning set.


A note on the application of information theory to studies of tracking behaviour.


A reply to Dr. Max Hammerton: a note on the application of information theory to studies of tracking behavior.


A study of the time course of recovery of Paramecium aurelia from the lethal effects of x-rays.


Chemical protection against 440-Mev protons in mice pretreated with mercaptoethylamine (MEA) or p-aminopropiophenone (PAPP).


Beta-mercaptoethylamine effect on radiation  dose-response characteristics of granulocyte and lymphocyte counts.


The radiolysis of aqueous methylammonium ion.


The Th228 decay series in adult beagles: Ra224, Pb212, and Bi212 in selected bones and soft tissues.


Chemical protection against absorber-moderated protons.


Comparative lethality responses of neutron- and x-irradiated dogs: influence of dose rate and exposure aspect.


Hair dysplasia induced by x-rays in mice under different irradiation conditions.


X-ray inactivation of papain coupled with a synthetic polypeptide.


Studies on some radiation-induced chromosome aberrations in man.


An outbreak of smallpox in an urban area.


Hypophosphatasia.

Hypophosphatasia.


Principles of occupational health.

Principles of occupational health.


Protein from petroleum.

Protein from petroleum.


The chemistry of cell membranes.

The chemistry of cell membranes.


Electrical effects in bone.

Electrical effects in bone.


The origins of facial expressions.

The origins of facial expressions.


A proposed code system for storage and retrieval of information in systematic zoology.


Hyperplasia of the thymus and related respiratory difficulties.


Modified Blalock shunt operation in tetralogy of Fallot.


Clinical investigation of neonatal diaper dermatoses.


Studies in neonatal diaper dermatitis. I. The use of hydroxyquinoline.


Studies in neonatal diaper dermatitis. II. Use of a powder containing undecylenate.


Particularities of the heart as a pump.

Particularities of the heart as a pump.


Retinal rivalry, vasomotor tone and sensory stimulation.


Malignant melanoma of the skin. A preliminary report.


Distribution of phenylthiocarbamide tasting phenotypes in students with different ancestry in Santiago, Chile.


Role of clasmatocytes in cell defense mechanisms against transplantable mouse tumors.


Venous occlusions in the liver following dimethylnitrosamine.


Studies of collagen synthesis in experimental  amyloidosis.


The mitotic response after subtotal hepatectomy in the rat.


The immunisation of rabbits with staphylococcal leucocidin toxoid. With a report on the pathological histology of their internal organs.


Porokeratosis (Mibelli).

Porokeratosis (Mibelli).


Delusions of parasitosis.

Delusions of parasitosis.


The finger nail in general disease. A macroscopic and microscopic study of 87 consecutive autopsies.


Phytohaemagglutinin induced mitotic stimulation of epithelial cells in organ culture of adult human skin.


A new approach to the treatment of cholera based on experimental evidence.


The immediate effect of antigens on the cell output of a lymph node.


A case of leprosy with unusual cutaneous manifestations.


The normal finger nail.

The normal finger nail.


Case for diagnosis: livedo with weakness.


Skin disease from colour developers.

Skin disease from colour developers.


Medical oasis in Saudi Arabia.

Medical oasis in Saudi Arabia.


Stabilization of inpatient bed occupancy through control of admissions.


Four-hospital agency boosts delinquent account collections.


Smallpox: a continuing threat.

Smallpox: a continuing threat.


Personnel productivity survey shows where improvements are needed.


Six hospitals study best means of assuring smallpox immunity among personnel.


Volunteers in a home care program. Why a well-laid plan went awry.


Organizing and operating an intensive care unit.


Contractual purchasing: indicator of departmental performance.


Profile of meat purchasing practices in Illinois hospitals, winter, 1965.


The genetic and biochemical aspects of angiohemophilia (Von Willebrand's disease).


The erythrocytic reduced glutathione in paroxysmal nocturnal hemoglobinuria.


Anhidrotic hereditary ectodermal dysplasia. Case report with a short review of the literature.


Alkaline phosphatase positivity in erythroblasts.


Steroid-induced intracranial hypertension.


Ichthyosis congenita. Brief review with a case report.


The nature of congestive heart failure due to rheumatic heart disease in childhood.


Human milk allergy.

Human milk allergy.


Progeria with unusual ocular manifestations: report of a case with a review of the literature.


Acute Budd-Chiari syndrome: a case report with a review of the literature.


Volvulus of the small intestine due to persistent vitellointestinal duct: a case report.


Non-aphasic disorders of speech.

Non-aphasic disorders of speech.


Examinations on inner speech.

Examinations on inner speech.


A study on changes in the latency period of verbal and nonverbal performances in aphasics.


Aphasia and intelligence.

Aphasia and intelligence.


Aphasia: a point of view as to the nature of the disorder and factors that determine prognosis for recovery.


Some classification of aphasic disturbances with special reference to rehabilitation.


A rapid screening test for aflatoxin-synthesizing aspergilli of the flavus-oryzae group.


Bacterial spoilage of thawed frozen peas.


The aerobic flora of stored meat with particular reference to the use of selective media.


Growth inhibition of staphylococci by sodium  thiosulphate.


The effect of sodium chloride on radiation resistance and recovery of irradiated anaerobic spores.


Correction and review on successive parts in learning a hierarchical task.


Effects of microwave cookery on the bacterial counts of food.


Labeling and variety in concept identification with young children.


A continued investigation of susceptibility to distraction in academically underachieving and achieving male college students.


Negro academic motivation and scholastic achievement.


Effects of differential feedback from examinations on retention and transfer.


Predicting five years of development in adolescents from readiness for vocational planning scales.


A study of backward chaining.

A study of backward chaining.


A measure of programing in teaching-machine material.


Classroom environment in different fields of study.


The treatment of glottic cancer. The importance of radiotherapy to the patient.


Transzygomatic approach for nasopharyngeal fibromata with extrapharyngeal extension.


"Pharapharyngeal" neurogenic tumors.

"Pharapharyngeal" neurogenic tumors.


Retropharyngeal lymphangioma.

Retropharyngeal lymphangioma.


Healed appearance following teflon piston stapedectomy.


Myopathia laryngis.

Myopathia laryngis.


Our first three laryngectomies.

Our first three laryngectomies.


The deviated nasal septum--II--prevention and treatment.


A spring prosthesis for stapes surgery.

A spring prosthesis for stapes surgery.


Chondromalacia patellae--a service problem.


Scope and diversity in naval ophthalmological practice.


An unusual foreign body in the throat.

An unusual foreign body in the throat.


Naval influences upon the surgery of peptic ulceration.


Some thoughts on the nuclear navy of the future.


The Naval Radiological Protection Service.


Naval health and the environment.

Naval health and the environment.


Medical problems of very deep diving.

Medical problems of very deep diving.


Excess DNA during matrix production.

Excess DNA during matrix production.


Some aspects of the chemical control of respiration in man.


High-intensity noise problems in the Royal Marines.


The changing pattern of tropical medicine in the Royal Naval Hospital, Plymouth.


Human endurance in intolerable climates.


Asymptomatic infections with respiratory viruses in a semi-closed community.


Pulmonary sarcoidosis in the Navy.

Pulmonary sarcoidosis in the Navy.