Lymphoma growth in vivo: electronic discrimination between tumor and stroma cells. Moloney lymphoma cells are larger than normal cells of mouse spleen, lymph-node, and thymus. Use of electronic cell-size anaylsis in conjunction with specific immunocytolysis permits difjerential counting of host and tumor cells. Increase of lymphoma cells occurs first in spleen and then in lymph nodes; in thymus it occurs only during the terminal stages of tumor growth.


Gastric secretion: mechanism for production of hydrogen ions. The passage of a direct electric current across a fixed-charge membrane interposed between neutral electrolyte solutions can give rise to the production of hydrogen and hydroxide ions at the solution-membrane boundary in equivalent amounts, each of which can approach and equal the number of faradays passed. At this unique boundary, the electric field can inhibit the rate of recombination of hydrogen and hydroxide ions strongly enough to increase the dissociation constant of water and other weak electrolytes by several orders of magnitude. These observations lead to a model of the gastric secretory process wherein the gastric potential, primarily due to the activity of a chloride-ion pump, is applied across an adjacent ionselective membrane also present in the mucosa. The dissociating weak electrolyte can be water, to produce hydrogen ions in the stomach and hydroxide ions which combine with carbon dioxide in the blood, or it can be carbonic acid to produce bicarbonate directly.


Alternative forms of triosephosphate dehydrogenase in Chromatium. Triosephosphate dehydrogenase was purified extensively from the obligately phototrophic bacterium Chromatium. Enzyme prepared from photolithotrophically grown cells differed in several properties from enzyme prepared from photoorganotrophically grown cells. Either form of the enzyme could be transformed in vitro to the other by mild oxidation or reduction, which effected both Michaelis constants and reactive -SH contents of the proteins.


Brain transplantation: prolonged survival of brain after carotid-jugular interposition. Six isolated canine brains were successfully transplanted for 6 hours to 2 days to the cervical vasculature of dogs. Viability was shown by electrocortical activity and significant uptakes of oxygen and glucose, with production of carbon dioxide. Cerebral blood flows, temperatures, and pressures of the cerebral homograft were continuously monitored by way of an implantable recording module.


Efficiency of the conditioned eyelid response. A method for estimating directly the efficiency of the conditioned eyelid response is capable of reflecting marked chaniges in response efficiency during acquisition of the conditioned response. conditioned response.


Rise of blood antithrombin level during coumarin therapy.


Effect of long-term anticoagulant therapy on antithrombin activity.


Treatment of chronic mucous and purulent pulmonary processes with trypsimusc.


A clinical epidemiologist looks at tuberculosis.


Application of a new diphasic hypnotic to tuberculous patients with impaired sleep.


Efficacy of treatment of pulmonary tuberculosis in a military population.


Inactive tuberculosis--a cause of death.


Pulmonary function survey in Westchester County.


Botryoid sarcoma (rhabdomyosarcoma) of the bile ducts.


Blood lactate in the respiratory distress syndrome: significance in prognosis.


Histidinemia.

Histidinemia.


Thrombosis of the main pulmonary artery in nephrosis: thromboembolism as a complication of nephrosis.


Tolnaftate in superficial fungus infections.


Parotid saliva in cystic fibrosis. 1. Flow rate.


Parotid saliva in cystic fibrosis. II. Electrolytes and protein-bound carbohydrates.


Hydrocephalus and myelomeningocele. Central nervous system infection.


Stokes-Adams syndrome in childhood: two cases of nonsurgically acquired origin.


Neonatal hypocalcemia and complete heart block.


Familial hypophosphatemic vitamin D resistant rickets: effect of increased oral calcium and phosphorus intake without high doses of vitamin D.


Torsion of the spermatic cord in the newborn.


Varicella and hypoglycemia with recovery: case report.


Intrapericardial teratoma: report of a case.


The diencephalic syndrome of infancy: report of two cases.


Picture of the month.

Picture of the month.


Radiological case of the month.

Radiological case of the month.


Cystic fibrosis of the pancreas: an estimate of the incidence.


Maximum-likelihood estimation of the proportion of nonpaternity.


Is hyperploidy of sex chromosomes associated with reduced total finger ridge count?


Heredity of blood groups in chimpanzees.


A complex familial chromosome translocation.


Role of surgical treatment of ulcerative colitis: review of 20 cases.


Treatment of recurrent pancreatitis: transduodenal sphincteroplasty and experience with pancreatic inhibition and retrograde drainage after resection.


Surgical revascularization after acute thrombosis of carotid artery.


Lobular carcinoma in situ of the breast.


Technic for combined, synchronous, abdominoperineal resection of the rectum with preservation of the sphincter.


Management of high voltage electrical burns: review of 16 cases.


Surgical management of penetrating injuries to the chest.


Achalasia of the esophagus: diagnosis and treatment.


Control of basal cell carcinoma: 10-year review.


Diagnostic role of barium in small bowel obstruction: review of 74 cases.


Embolectomy for acute massive pulmonary embolism.


Pathogenesis and management of Ménière's syndrome in terms of microcirculation. Pharmacologic decompression of the endolymphatic hydrops.


Candida albicans, a contributing cause of torpid vascular ulcers of the lower extremities.


Carotid arteritis.

Carotid arteritis.


Renovascular hypertension. A review of reversible causes due to extrinsic pressure on the renal artery and report of three unusual cases.


Pneumatic needle holders for vascular and microvascular procedures.


Carotid artery surgery for cerebral vascular insufficiency.


Nervous control mechanism of the renal vascular tone.


The sites of hemoglobin catabolism.

The sites of hemoglobin catabolism.


Circulating megakaryocytes and platelet release in the lung.


Effect of anticoagulant and ABO incompatibility on recovery of transfused human platelets.


Platelet tagging with tritium labeled diisopropylfluorophosphate.


Giant hemangioma with thrombocytopenia. Radioisotopic demonstration of platelet sequestration.


Elaboration of a model for the formation of lymphocytes in the thymic cortex of young adult rats.


Human bone marrow chromosomes in megaloblastic anemia.


Relation of reticulocytosis to positive Coombs tests in NZB and other mice.


Unstable chromosome changes in tuberculin-stimulated leukocyte cultures from irradiated patients. Evidence for immunologically committed, long-lived lymphocytes in human blood.


A clinical and experimental study of acquired inhibitors to factor 8.


The early loss of radioactivity in Cr51 survival curves: destruction of cells or loss of the label?


Bilirubin formation in the liver from nonhemoglobin sources. Experiments with isolated, perfused rat liver.


Cancer of the cheek (mucosa).

Cancer of the cheek (mucosa).


Spontaneous regression of primary malignant melanomas with regional metastases.


Neoplastic Paneth cells; their occurrence in 2 adenomas and one carcinoma of the colon.


Synchronous tumors in patients with multiple primary cancers.


Evaluation of Rotter's lymph nodes in radical mastectomy specimens as a guide to prognosis.


Ultrastructure of pilomatrixoma (calcifying epithelioma).


Return of renal function following diversion of the obstructed ureter.


Recurrent and metastatic carcinoma in surgically treated carcinoma of lung. An autopsy survey.


Adrenal insufficiency due to metastatic carcinoma of the lung. Case report and review of Addison's disease caused by adrenal metastases.


Influence of cell collection techniques upon cytological diagnosis.


Carcinoma of the vagina in infancy.

Carcinoma of the vagina in infancy.


Continuous intra-arterial chemotherapeutic infusion utilizing a portable syringe.


A total cervical esophageal reconstruction. Five-year follow-up.


Maturation of tumors of the sympathetic nervous system. Report of long-term survival in 2 patients, one with disseminated osseous metastases, and review of cases from the literature.


Absorption spectra of riboflavin, lumiflavin, and lumichrome in organic solvents.


Influence of ionizing radiation on protein production by HeLa cells in culture.


A demonstrable local and geometric increase in the chromosomal DNA of Chironomus.


On the binding of gelatine to modified serum proteins through formaldehyde in an experimental blood volume expander.


A study of DNA synthesis in sea urchin hybrids by the incorporation of H3-thymidine.


Agglutinating antibrain antibodies in dogs with experimental allergic encephalomyelitis.


A new pseudoabnormal hemoglobin in hemolytic anemias.


Blood cholinesterase in adrenalectomized rats.


Estrogen-induced uterine metaplasia in rats given oral supplements of vitamin A.


Effect of agar on bradykininogen levels and esterolytic activity in rat plasma.


Gastric excretion of C-14-nicotine.

Gastric excretion of C-14-nicotine.


Ontogenetic fate of the neurosecretory cells in the larval brain of Sarcophaga ruficornis (Fabricius, 1794) (Diptera: Cyclorrhapha).


Liver phospholipides after carbon tetrachloride intoxication in rats.


The changes of gastric histidine decarboxylase activity during fasting and feeding.


Nervous activity of the frog's epiphysis cerebri in relation to illumination.


Acute toxicity and elimination of phenol injected into fish (Carassius auratus L.).


Stasis-induced changes in platelet adhesiveness.


Depression of post-tetanic potentiation in the spinal cord by morphine and pethidine.


Extraction and analysis of histone protein from the roots of three plant species.


A rapid technique for characterizing metal-protein complexes by pH-metry.


Squamous cell carcinoma of the body of the uterus. A case of primary squamous cell carcinoma of the body of the uterus is reported. The number of authentic cases of this tumour which meet the rigid criteria referred to is extremely small. The histological findings are described in detail and some aetiological considerations are mentioned briefly. Certain special aspects of the diagnosis are discussed.


Phycomycosis of the bronchus.

Phycomycosis of the bronchus. A case of phycomycosis of the bronchus in a 29-year-old diabetic man is reported. The interval between infection and death was not less than 35 days. Infection of the bronchus appears to have been direct. The diagnosis of phycomycosis could have been made before death.


Primary malignant lymphoma of the uterus. The clinical and pathological findings in a 59-year-old woman with a primary malignant lymphoma of the corpus uteri are described. There was a period of eight months between detection of the uterine lesion and evidence of disease elsewhere in the body. The patient died of disseminated lymphoma, and the distribution of secondary deposits were suggestive of spread via the right ovarian-uterine venous system.The criteria for acceptance of a diagnosis of primary uterine lymphoma are discussed and the previous literature is reviewed. There have been nine acceptable cases of primary uterine lymphoma recorded: four in the corpus uteri and five in the cervix. The differential diagnosis from stromal sarcoma, anaplastic endometrial adenocarcinoma, leiomyosarcoma, and benign lymphoid hyperplasia is discussed.


Histological study of two cases of Coxsackie B virus pneumonia in children. Two cases of interstitial pneumonia are described. They were characterized by mononuclear cell infiltration of the alveolar walls and protein-rich exudate into the alveolar cavities, with localized hyaline membrane formation. Coxsackie B5 virus was isolated from the lungs of both patients at necropsy.


Comparison of selective media for the isolation of salmonellae. A study of the selective action of four fluid media used for the isolation of salmonellae is described. When incubated in the presence of three competing organisms, test strains were recovered most frequently from Rappaport medium but mannitol selenite broth proved superior for the isolation of S. typhi.


Efficacy of different selective media for the isolation of salmonellae from faeces. Comparative results obtained in isolating salmonellae from faeces by the use of tetrathionate broth, MS, and MM enrichment medium are given. The best results were obtained by tetrathionate broth prepared from infusion broth. The MS as well as the MM medium increased the total number of positive results.


A non-starch-fermenting variant of Corynebacterium ulcerans. Recently a non-starch-fermenting strain of C. ulcerans was isolated and a strain which did not hydrolyse urea when first isolated has also been discovered. For full identification of C. ulcerans both intradermal and subcutaneous tests in guinea-pigs are required, and it is recommended that these tests should be carried out with all organisms which culturally and morphologically resemble diphtheria bacilli.


Lactic dehydrogenase isoenzymes in normal and pathological spinal fluids. Spinal fluid lactate dehydrogenase (L.D.H.) isoenzyme patterns have been investigated in normal subjects, in those with non-destructive nervous disease, and in those with destructive lesions in the nervous system.The spinal fluid from organic disease in general showed a significantly increased level of L.D.H.(2) and L.D.H.(3) so that the combined values of L.D.H.(2) and L.D.H.(3) might perhaps be of value in determining the presence of destructive nervous lesions.


Alpha-amino nitrogen in cerebrospinal fluid and its alterations in meningitis, multiple sclerosis, and some other neurological disorders. The concentration of alpha-amino nitrogen (a measure of total amino-acids) was estimated in 58 samples of cerebrospinal fluid in which other findings were normal. Values for lumbar and ventricular cerebrospinal fluid in adults, and lumbar cerebrospinal fluid in children, are reported. A relationship was found between the concentrations of alpha-amino nitrogen in lumbar cerebrospinal fluid and in plasma.Alpha-amino nitrogen was also estimated in 79 samples of fluid from patients with meningitis, cerebral tumour, multiple sclerosis, and other neurological disorders. High concentrations were found in meningitis, spinal block, and xanthochromic fluids. In cerebral tumours, the concentrations were mostly normal. Low concentrations were found in children, in many cases of multiple sclerosis, and in benign intracranial hypertension. In some cases, the changes cannot yet be explained.


Human urinary amylolytic enzymes in acute hepatitis. Using paper eletrophoresis two amylolytic enzymes in human urine were demonstrated. A main peak was shown in the gamma globulin zone in normal urine and a second minor peak, in contrast to earlier findings, in the beta globulin zone. The organic source of the minor peak is probably in the liver. Urines from cases of acute hepatitis were studied in the same way and showed that the electrophoretic beta peak was raised in acute hepatitis, also pointing to a possible origin in the liver. Further studies are required to confirm this hypothesis.


Micromethod for the determination of uric acid in biological fluids. A micro procedure for estimating uric acid in body fluids, based on the carbonate method, is described. Interferences are elucidated. The stoichiometry of the reaction is carefully worked out. Reliability of the method is established by comparison with two other methods, by recovery experiments, and by replicate analyses.


Quantitative aspects of the excretion of radioactive and microbiologically active material in urine after parenteral hydroxocobalamin. The radioactive material in urine after parenteral radioactive hydroxocobalamin is composed of radioactive cyanocobalamin, radioactive hydroxocobalamin, and a radioactive anionic complex. Studies in vitro suggest that these materials have a similar microbiological activity. Comparison of the amounts of radioactive and microbiologically active material in urine after parenteral radioactive hydroxocobalamin show a significant correlation both in the first and second 24 hours after injection showing that the amount of radioactivity is an acceptable measure of the loss of cobalamin in urine. The slope of the regression lines obtained from cobalamin-deficient and normal subjects implies that there is no equilibration of injected radioactive hydroxocobalamin and body stores: this may be due to the absence of hydroxocobalamin from tissues or to the fact that tissue hydroxocobalamin is bound and incapable of equilibration.


Effect of previous irradiation on the transformation of blood lymphocytes. The transformation of blood lymphocytes in cultures with phytohaemagglutinin was studied in five patients before and at intervals up to 18 to 19 months after therapeutic irradiation of the abdomen and pelvis (dose of x rays 3,200r to 4,475r). In one patient, all cultures showed satisfactory lymphocyte transformation. In four patients transformation was depressed following irradiation. In three of these patients the duration of the depression was short; in one patient it was prolonged for over a year. The poor response of the lymphocytes to phytohaemagglutinin was not associated either with leucopenia or with a high incidence of cells with chromosome abnormalities in the cultures.


Rapid electrophoresis and quantitation of haemoglobins on cellulose acetate. A rapid and reproducible electrophoretic method for the separation and quantitation of haemoglobins on cellulose acetate is described. The accuracy of the method and its possible sources of error are discussed. The normal range for haemoglobin A(2) by this method is 1% to 3% of the total haemoglobin concentration. Blood samples from 32 thalassaemic patients showed haemoglobin A(2) values of 3.5% to 7%.


Value of the Jirgl flocculation test in the diagnosis of jaundice. The Jirgl flocculation test has been compared with the combination of the thymol reactions and serum alkaline phosphatase determination recommended by Maclagan in the investigation of 68 patients with jaundice. The test was found to be of value in distinguishing biliary obstruction from other causes of jaundice, but failed to distinguish between extrahepatic and intrahepatic biliary obstruction. Serum glutamic oxalacetic transaminase and serum glutamic pyruvic transaminase estimations were performed in a number of cases, but were found to be of no value in the diagnosis of jaundice.


Excretion of tryptophan metabolites in Friedreich's ataxia. The overnight urinary excretions of the tryptophan metabolites 5-hydroxy indole acetic acid (5HIAA), indole acetic acid (IAA), indoxyl sulphate, and kynurenine were determined in 10 cases of Friedreich's ataxia and in 11 controls. Levels of 5HIAA and IAA were slightly lower and of indoxyl sulphate higher than in the controls but within normal limits; kynurenine was normal.A tryptophan load test subsequently given to four patients and three controls showed no significant abnormality in IAA, 5HIAA, indoxyl sulphate, and kynurenine.A specific abnormality in tryptophan metabolism in Friedreich's ataxia suggested by other workers was not observed.


Urea and oxalate inhibition of the serum lactate dehydrogenase. The serum lactate dehydrogenase (LDH) of 16 normal subjects was inhibited by 55 to 68% by the incorporation into the reaction mixture of 0.2 mM-oxalate. Oxalate inhibited the serum LDH of 17 out of 19 patients with myocardial infarction to a greater extent, and that of 16 out of 18 patients with liver disease to a lesser extent than that of the controls. The serum LDH of all 16 patients with liver disease was inhibited by 2 M-urea to a greater degree and that of eight out of nine patients with myocardial infarction to a lesser extent than that of the normal controls (45-62%). The serum LDH of five patients with megaloblastic anaemia was also less sensitive to inhibition by urea than was that of the controls. The inhibitory effect of oxalate was greatest with those sera containing an excess of the electrophoretically fast LDH isoenzymes, while that of urea was most marked with those sera in which the slow LDH isoenzymes preponderated. The results of inhibition studies with urea or oxalate correlated well with other indices of isoenzyme composition. The use of oxalate or urea is recommended as an aid in the enzymatic diagnosis of heart and liver disease, especially when the results of other enzyme tests are equivocal.


Histochemical localization of copper in the gastrointestinal tract of the rat. Three histochemical reactions for the localization of copper were applied to liver and different parts of the gastrointestinal tract of normal as well as of rats poisoned with a solution of copper. Variable quantities of copper were demonstrated in the livers of all the poisoned rats and in 21 out of 24 sections of jejunum. Rubeanic acid counterstained with 0.5% Cresyl violet gave the best results. Copper was not demonstrable in the livers or the gastrointestinal tract of normal rats. As the metal was concentrated in the upper jejunum, it is likely that this is the site of absorption. Detection of this metal may assist in the diagnosis of hepatolenticular degeneration.


Tests for rheumatoid factor after myocardial infarction. An investigation was carried out into the occurrence of positive tests for rheumatoid factor after myocardial infarction. Fifty-five patients, 41 males and 14 females, were studied in 56 separate admissions for acute myocardial infarction. Tests for thyroid antibodies were also performed on all patients. In 16 patients a positive rheumatoid factor test was obtained in the post-infarction period on at least one occasion. The reaction was usually a weak positive one, and in most cases had disappeared on discharge from hospital. Transient false positive tests for thyroid complement-fixing antibody were obtained in seven male patients.Positive tests tended to occur in older patients, with a previous history of infarction, and usually with more severe infarcts, as judged from the maximum level of serum glutamic oxaloacetic transaminase obtained in the first 48 hours after infarction, and the occurrence of clinical cardiac failure. This is probably a relatively non-specific manifestation of tissue damage, the clinical importance of which is unknown.


Pseudocholinesterase activity in thyroid disease. The present evidence indicates that serum pseudocholinesterase activity is increased to about 20% above the normal level in thyrotoxicosis and decreased by about 30% in myxoedema. Treatment restores the esterase level to the average mean activity of random normal as the patient becomes euthyroid. There is no evidence in the present investigation that any of the pseudocholinesterase variants modify these conclusions.


Specific agglutination of tanned red cells coated with a globulin fraction of an antithyroid serum by saline extracts of thyroid glands. Experiments are described in which tanned red cells coated with a globulin fraction of human serum with a high titre of antibody to human thyroglobulin were agglutinated by saline extracts of human thyroid gland and thyroglobulin but not by other tissue extracts. It is suggested that the linkage is due to a specific antigen antibody reaction between cell-bound antithyroid antibody and thyroglobulin in solution.


Immunologic defect in patients recovered from sarcoidosis.


Impaired in vitro lymphocyte transformation in Hodgkin's disease.


Brachial-artery bruits in aortic-valve disease and hypertrophic subaortic stenosis.


An unusual case of Cushing's syndrome.

An unusual case of Cushing's syndrome.


Surgeons' Hall--the story of the first medical-school building in the United States.


Primary cutaneous tuberculosis resulting from mouth-to-mouth respiration.


Fee setting--the patient's ability to pay.


Case records of the Massachusetts General Hospital. Case 48-1965.


Physiologic observations in human cross circulation.


The effect of eserine and 5-hydroxytryptamine on the peristaltic propulsive activity of the isolated guinea-pig ileum.


Investigations of human blood griseofulvin levels and their relation to the curative effect in tinea capitis.


Tuberculosis first registered at death.

Tuberculosis first registered at death.


Daily Pco-2 and pH fluctuations in pulmonary emphysema with carbon dioxide retention.


The influence of lung volume, flow rate, and esophageal pressure on the sagittal diameter of the trachea in patients with and without airway obstruction.


Solitary plasmacytoma of  the trachea.

Solitary plasmacytoma of  the trachea.


Dynamics of major airways in patients with lung disease.


Simultaneously occurring pulmonary coccidioidomycosis and histoplasmosis.


Ethionamide, 750 mg. daily, plus isoniazid, 450 mg. daily, in previously untreated cases of pulmonary tuberculosis.


Estimation of differential pulmonary blood flow by bronchospirometry and radioisotope scanning during rest and exercise.


A comparison of jet injection with the Mantoux test in mass skin testing with tuberculin.


Volume-pressure relations of the respiratory system of curarized infants.


The achievements of the past and challenges of the future.


Carbon monoxide accumulation in closed circle anesthesia systems.


Blood pH and plasma levels of d-tubocurarine.


Mechanics of breathing during anesthesia. 2. The influence of airway adequacy.


Pulmonary compliance in anesthetized man.


Effects of nitrous oxide--curare, ether and cyclopropane on postoperative respiratory adequacy.


Temperature dependence of halothane and cyclopropane anesthesia in dogs: correlation with some theories of anesthetic action.


Inhalation anesthetics and permeability of human erythrocytes to monosaccharides.


Intravenous regional anesthesia of the upper extremity.


Minimum alveolar anesthetic concentration: a standard of anesthetic potency.


Forearm venous and arterial respones to halothane and cyclopropane.


Human cerebrospinal fluid osmolality at 37-degree c.


Hyperbaric oxygenation: anesthesia and drug effects.


Performance of lungs and bronchi during inhalation anesthesia.


Flammability of fluroxene.

Flammability of fluroxene.


Residual curarization.

Residual curarization.


The electron cytochemistry of ubiguinone in mammalian heart, demonstrated with a momotetrazolium salt.


A nerve stimulator for the continuous monitoring of muscle relaxant action.


Observations on the application to electron microscopy on the lead phosphate technique for the demonstration of acid phosphatase.


Brain scanning with radioisotopes for diagnosis of intracranial lesions.


The use of phenazinemethosulphate as an electron carrier in the histochemical demonstration of dehydrogenases.


Bronchopulmonary geotrichosis.

Bronchopulmonary geotrichosis.


Transient nature of the T wave changes.

Transient nature of the T wave changes.


Handle my tissues with loving kindness.

Handle my tissues with loving kindness.


Hepatic venography and hepatic venous pressure recordings in the evaluation of portal hypertension.


Surgical management of atherosclerotic disease of abdominal aorta and lower extremities.


Radiation pneumonitis and fibrosis.

Radiation pneumonitis and fibrosis.


Surgical treatment of carcinoma of esophagus.


Hysterosalpingography.

Hysterosalpingography.


The constitutionality of the Louisiana Medical Practice Act and the legality of the operations of the Louisiana State Board of Medical Examiners under the act.


Results of a questionnaire submitted to physicians' children.


Pancreatitis and acute rheumatic fever.

Pancreatitis and acute rheumatic fever.


Return of viability of the intestine with restoration of the blood supply.


Clinico-pathological exercise.

Clinico-pathological exercise.


The outhouse kid.

The outhouse kid.


Report, board of censors and state committee on public health--midyear conference November 18, 1965.


Report of primary metallic fixation in open fractures.


Total replacement of aortic valve.

Total replacement of aortic valve.


Books as clinical tools. Clinical scholarship: an underdeveloped art.


The Pennsylvania study.

The Pennsylvania study.


Studies on inflammation. Fate of intramural vascular deposits induced by histamine.


Experimental bacillary dysentery. An electron microscopic study of the response of the intestinal mucosa to bacterial invasion.


The light and electron microscopic autoradiographic demonstration of local amyloid formation in spleen explants.


Fine fibrils of extracellular space (microfibrils). Their structure and role in connective tissue organization.


Plaque formation and periodontal pathology in gnotobiotic rats infected with an oral actinomycete.


Spectrum of fine structural changes in hepatocellular injury due to thioacetamide.


Vascular lesions in anti-kidney serum nephritis of the rat.


On the relation of enterosiderosis pigments of man and guinea pig. Melanosis and pseudomelanosis of colon and villi and the intestinal iron uptake and storage mechanism. Histochemical and experimental studies.


Peripheral vascular lesions in rheumatoid arthritis.


Cutaneous hemangiomas and disappearing bones. With a review of cutaneo-visceral hemangiomatosis.


Acro-angiodermatitis of the foot.

Acro-angiodermatitis of the foot.


CRST syndrome. A benign variant of scleroderma.


Scleredema adultorum. Not always a benign self-limited disease.


Sjögren-larsson syndrome. Congenital ichthyosis, spastic paralysis, and oligophrenia.


Palmar keratoses and cancer.

Palmar keratoses and cancer.


Nail changes in keratosis punctata.

Nail changes in keratosis punctata.


Elastosis perforans serpiginosa. Report of a family with a chromosal investigation.


Benign mucous membrane pemphigus with a generalized eruption.


Letterer-Siwe disease. Report of a case emphasizing effective corticosteroid therapy.


Basal cell epithelioma of the palm.

Basal cell epithelioma of the palm.


Aplastic anemia induced by quinacrine.

Aplastic anemia induced by quinacrine.


Dimethylacetamide (DMAC) and dimethylformamide (DMFA). Effect on percutaneous absorption.


Homotransplantation of dystrophic and normal muscle.


Response of the iron-loaded liver to prolonged ethionine feeding.


Hepatic ultrastructure in chronic idiopathic jaundice.


Prostatic corpora amylacea. A study with the electron microscope and electron probe.


The degree of coronary atherosclerosis in aortic valvular disease.


Hepatobiliary changes in erythropoietic protoporphyria.


Comparison of pathologic effects of experimental thromboembolism. Effects in peripheral and pulmonary arteries of the rabbit.


Studies of postmortem microbiology using sterile autopsy technique.


Preoperative irradiation in the treatment of carcinoma of the hypopharynx. The results of treatment of 230 cases of carcinoma of the hypopharynx seen at the University of Toronto and the Princess Margaret Hospital, between the years 1951 and 1963, are presented. The recommendations of the American Joint Committee have been followed in the classification of these tumours: 127 of the 230 were located in the pyriform sinuses.The overall five-year survival rate for lesions of the pyriform sinus was 9% as opposed to 20% for tumours in the other regions of the hypopharynx. Surgical treatment alone was used in 44 of these cases, and the five-year net survival figure was 23%. This compared favourably with the overall survival figure of 8% for those treated primarily by radiotherapy.Elective preoperative irradiation leads to improved survival rates. Palliation for Stage IV lesions should be achieved by radiography. The two-stage method of surgical reconstruction remains the surgical procedure of choice despite current enthusiasm for the use of visceral transplants.


Hematocrit and coronary heart disease.

Hematocrit and coronary heart disease. Hematocrit values of patients with acute myocardial infarction have been reported by some workers to be higher than those found in controls; this has been denied by others. In these reported studies important postural, postprandial, age and stress effects have not been considered. In the present investigation hematocrits of healthy and coronary subjects were determined under the same "standard basal" conditions, in the morning hours, fasting or after a light breakfast, and in sitting position; patients studied had no acute illness or distress. A mean hematocrit of 49.1 +/- 2.4% was observed in 66 men with chronic coronary disease and of 46.8 +/- 3.2% in 68 healthy controls of the same age and sex, the difference being highly significant. The increased hematocrit and plasma viscosity in coronary patients creates significantly higher whole blood viscosity than that observed in healthy controls. This hemodynamic factor may be responsible for the development of clinical symptoms of coronary heart disease and possibly of the basic vascular disease itself.


The elusive source of psittacosis in the Arctic. Eskimos and Arctic Indians have a high incidence of psittacosis antibodies. The following Arctic birds were therefore examined in an endeavour to find the reservoir of infection: snow geese in their Arctic nesting grounds; migrating geese in the spring and in the fall; ptarmigan, raven, and snow bunting on the Arctic Circle in the late winter. Psittacosis virus was not recovered from any of the birds examined, but a percentage of migrating geese had psittacosis antibodies. The source of human and avian antibodies in the Arctic remains elusive.


Pulmonary embolism.

Pulmonary embolism.


Diagnosis and treatment of delirium.

Diagnosis and treatment of delirium. Delirium is not a clinical entity but a symptom-complex of manifold etiology. Its presence signifies acute cerebral insufficiency and often represents a medical and/or psychiatric emergency.Though some forms of delirium have distinctive features, the fundamental phenomena are common to all, with clouding of consciousness the sine qua non. The condition has two major components: (1) the basic "acute brain syndrome" and (2) associated release phenomena.Clinicians must first make the vital differentiation between delirium and "functional" mental disorder, then proceed with the elucidation of the underlying diagnosis and the concurrent organization of symptomatic and etiologic treatment.Proper treatment combines management of the acute brain syndrome with general and specific procedures for control of the underlying condition. Dealing with the symptom-complex itself involves the principles and practice of sedation, hydration, and nutrition, nursing care and supportive measures. Provided the basic organic condition is treatable, the prognosis today is usually good.


School shock.

School shock.


Iron chelation in acute iron poisoning and chronic hypersiderosis.


The obese adolescent. Observations on etiology, management, prevention.


Pulmonary artery banding in infants and children; indications and results of the procedure.


Septicemia and meningitis in a newborn due to Pasteurella multocida.


Practical observations and reflections. II. Vomiting without organic cause.


Failure to thrive in early infancy due to abnormalities of rotation of the mid-gut.


Interested in practicing pediatric dermatology? Comments on this little known subspecialty.


Vertigo and drop attack. With special reference to cerebrovascular disorders and atherosclerosis of the vertebral-basilar system.


The palmomental reflex in the aged.

The palmomental reflex in the aged.


The clinical application of mammography.


The doctor's dilemma: tuberculosis or lung cancer?


Orthopedic treatment of pathological fractures of the spine.


What happens to the stroke victim?

What happens to the stroke victim?


What should the physician tell the patient with cancer?


Muscle disease of older patients.

Muscle disease of older patients.


Clinicopathological conference. Presentation of case: Minneapolis Veterans Administration Hospital.


Religion in old age.

Religion in old age.


The extramural care program of a modern home for the aged.


Communication between geriatrics and gerontology.


A case of generalized lipodystrophy.

A case of generalized lipodystrophy.


Phagocytic activity of leucocytes in premature infants. I. Comparison of the phagocytic activity of leucocytes between premature infants and full-term infants.


Nardostachys jatamansi: a chemical, pharmacological and clinical appraisal.


Equilibrium measurements of the binding of cytidine 3'-phosphate to ribonuclease.


Relaxation spectra of ribonuclease. 3. Further investigation of the interaction of ribonuclease and cytidine 3'-phosphate.


Relaxation spectra of ribonuclease. II. Isomerization of ribonuclease at neutral pH values.


Dynamic viscoelastic properties of solutions of paramyosin and bovine serum albumin.


Excimer fluorescence in liquid phenol, p-ethylphenol, and anisole.


The electronic properties of the 1,2- and 1,7-dicarbaclovododecaborane(12) groups bonded at carbon.


Nucleophilic reactions of 1-(N,N-dimethylcarbamoyl)pyridinium chloride.


The gem effect. I. The influence of 3-substituents on the rates of solvolysis of glutaric anhydride. A conformational analysis.


The gem effect. II. The influence of 3-mono- and 3,3-disubstitution on the rates of solvolysis of mono-p-bromophenyl glutarate.


The gem effect. 3. The influence of 3-mono- and 3-gem substitution on the acid dissociation constants of glutaric acid. A comparison of the sensitivity of delta-pK-a of dicarboxylic acids and the rate of ring closure of their monoesters to the intramolecular distance separating carboxyl functions.


Mass spectrometry in structural and stereochemical problems. LXXIX. Aliphatic and alicyclic nitro compounds.


Mass spectrometry in structural and stereochemical problems. LXXXI. Stereospecificity in a hydrogen-transfer reaction characteristic of 6-keto steroids.


Mass spectrometry in structural and stereochemical problems. LXXXII. A study of the fragmentation of some Amaryllidaceae alkaloids.


On cysteine and cystine peptides. 3. Synthesis of a fragment of insulin containing the intrachain disulfide bridge.


Purine nucleosides. XI. The synthesis of 2'-deoxy-9-alpha- and-beta-D-ribofuranosylpurines and the correlation of their anomeric structure with proton magnetic resonance spectra.


The synthesis of 1-(2'-deoxy-alpha- and -beta-D-ribofuranosyl)benzimidazoles related to the naturally occurring nucleosides of vitamin B12.


The kinetics of the trypsin-catalyzed hydrolysis of p-nitrophenyl alpha-N-benzyloxycarbonyl-L-lysinate hydrochloride.


The trypsin-catalyzed hydrolysis of the p-nitrophenyl, methyl, and benzyl esters of alpha-N-benzyloxycarbonyl-L-lysine.


Transient formation of an inactive intermediate in the reaction with alpha-N-benzoyl-L-arginine ethyl ester and alpha-N-benzoyl-L-arginine.


Molecular weight and molecular weight distribution of unfractionated yeast transfer ribonucleic acid.


Structures of leurocristine (vincristine) and vincaleukoblastine. X-ray analysis of leurocristine methiodide.


The structure of ophiobolin, a C25 terpenoid having a novel skeleton.


Reaction of triaminophosphines with oxomalonic esters, vicinal triketones, and o-quinones. Triaminooxyphosphonium dipolar ions.


Aminomalononitrile and 4-amino-5-cyanoimidazole in hydrogen cyanide polymerization and adenine synthesis.


Studies on the hydrolysis of cyclophosphamide. I. Identification of N-(2-hydroxyethyl)-N'-(3-hydroxypropyl)ethylenediamine as the main product.


Neighboring group participation in acetal hydrolysis.


Transition metal ion promoted hydrolyses of amino acid esters.


Studies of the sedimentation velocity of ovalbumin in concentrated salt solutions.


Refractive index dispersion in equine hemoglobin solutions.


The absence of lymphocyte response in vitro to tuberculin challenge in Hodgkin's disease.


40K and 137Cs measurements with the Bologna whole-body counter.


Analytical roentgenkymography and fluoroelectrokymography in mitral valvular disease.


Dietary therapy in the management of hepatic cirrhosis.


RADIATE: a new concept for computer coding, transmitting, storing, and retrieving radiological data.


Thermography: report of the radiographic and thermographic examinations of the breasts of 100 patients.


Calcium in the fluid of mediastinal bronchogenic cyst: a new roentgenographic finding.


Transtracheal selective bronchography.

Transtracheal selective bronchography.


Pulmonary varicosity.

Pulmonary varicosity.


Wedge pulmonary arteriography in congenital heart disease.


Cardiac mensuration by the cardiac volume method.


Extrinsic pressure defects on the duodenal loop in mesenteric occlusive disease.


Demonstration of ventricular aneurysms by radioisotope scanning.


Ulcerative colitis in association with diverticular disease of the colon.


Cholecystography in the presence of polycystic disease of the liver; report of a case and review of the literature.


Tannic acid and the barium enema.

Tannic acid and the barium enema.


Pelvic angiography in the management of abdominal pregnancy.


Deformity of the bladder secondary to pelvic lymphoma.


Roentgen manifest- ations of blow-out fracture of the orbit.


Sagittal diameter of the lumbar spinal canal in children and adults.


The gonadal x-ray dose to children from diagnostic radiographic technics.


Tumor--air ratio calculators.

Tumor--air ratio calculators.


A device to facilitate threading of cobalt-60 beads.


Cobalt-60 rotational therapy calculator.


Computers in radiology: a suboptimal utilization.


Serology in a general hospital.

Serology in a general hospital.


Influence of lysozyme on the Treponema pallidum immobilization test performed by utrilla-bravo technic.


The prothrombin consumpion time test.

The prothrombin consumpion time test.


Evaluation of serologic tests for syphilis in a state hygienic laboratory.


An improved water-bath for coagulation tests.


Recording osmotic fragility of red cells on the spinco analytrol.


The fine lines in traffic violence.

The fine lines in traffic violence.


Epidemic of lost tranquility.

Epidemic of lost tranquility.


Prognosis and surgical treatment of cancer of the stomach.


Curable metastatic tumors of childhood.

Curable metastatic tumors of childhood.


Tumors of the stomach.

Tumors of the stomach.


A new look at villous adenomas.

A new look at villous adenomas.


Echoencephalography: a clinical appraisal.


Tuberculous enterocolitis.

Tuberculous enterocolitis.


Clinicopathologic conference.

Clinicopathologic conference.


Context and the properties of behavior.

Context and the properties of behavior.


The familial occurrence of chronic obstructive pulmonary disease.


Exfoliative cytology in the diagnosis of stomach cancer.


Familial emphysema.

Familial emphysema.


Familial amyloid-producing medullary thyroid carcinoma and pheochromocytoma. A distinct genetic entity.


The association of nocturnal angina pectoris with dreaming.


Fabry's disease (angiokeratoma corporis diffusum): case report on a rare disease.


The nephrotic syndrome in secondary syphilis: report of a case with renal biopsy findings.


Response to sodium fluoride in severe primary osteoporosis.


Chronic fluoride intoxication with fluorotic radiculomyelopathy.


Cytological diagnosis.

Cytological diagnosis.


Homocystinuria due to cystathionine synthase deficiency.


Linolenic acid and coronary thrombosis.

Linolenic acid and coronary thrombosis.


The nondiagnosis of pernicious anemia.

The nondiagnosis of pernicious anemia.


Ferrokinetics in hyperthyroidism.

Ferrokinetics in hyperthyroidism.


The relation of capillary angiopathy and diabetes mellitus to idiopathic edema.


The cortisone-glucose tolerance test. The influence of age on performance.


Twelve years' experience with gas mediastinography (770 cases). Results obtained in cancer of the lung.


Work of breathing before and after bronchodilators in patients with emphysema.


Should the asymptomatic patient with active pulmonary tuberculosis be hospitalized?


Bronchogenic carcinoma in young people.

Bronchogenic carcinoma in young people.


The surgical treatment of pericarditis: a follow-up study.


Death in status asthmaticus: a clinical analysis of eighteen cases.


Electrocardiographic changes during gastric hypothermia.


Study of regional ventilation and perfusion using radioactive xenon in emphysema.


Subscalene biopsy in intrathoracic diseases.


Unusual cancer of the lung. I. Primary adenocarcinoma of the lung.


Coarctation of the abdominal aorta. Report of a case and review of the literature.


Roentgenogram of the month.

Roentgenogram of the month.


The electrocardiogram in strictly posterior myocardial infarction.


Aortic aneurysm secondary to mediastinal abscess. Report of two cases.


Agammaglobulinemia with bronchopulmonary manifestations. Report of a case.


Intrathoracic pheochromocytoma. Report of a case.


Iodoliposputosis following lymphangiography. Report of a case.


Worldwide chest medicine. Chest medicine and cardiovascular conditions in Great Britain.


Rx free system: economic or psychological barrier?


Brand specification.

Brand specification.


Drug distribution under national health insurance plans.


West African witch doctor.

West African witch doctor.


Caribbean adventure in Puerto Rican hills.


A short history of placebos.

A short history of placebos.


Rx for prescription order copies.

Rx for prescription order copies.


PTA (factor XI) levels and coagulation studies after plasma infusions in PTA-deficient patients.


A rapid, modified ultrafiltration method for determining serum protein binding and its application to new penicillins.


The interpretation of agar-gel precipitin reactions in histoplasmosis.


Free fatty acid turnover and triglyceride metabolism after ethanol ingestion in man.


Adsorption of I-131-triiodothyronine (T3) from serum by charcoal as an in vitro test of thyroid function.


A double isotope method for measurement of intestinal absorption of calcium in man.


Seattle variant of glucose-6-phosphate dehydrogenase.


Modifications of the helium dilution method of measuring human body volume.


The differential diagnosis in so-called rheumatic diseases.


The structure of catalpalactone.

The structure of catalpalactone.


(+)-Reticuline--a new opium alkaloid.

(+)-Reticuline--a new opium alkaloid.


Configuration of reticuline in the opium poppy.


Synthesis of Lycopodium alkaloids. II. Development of stereospecific synthetic methods.


Duclauxin, a metabolite of Penicillium duclauxi (Delacroix).


The x-ray study of monobromoduclauxin.

The x-ray study of monobromoduclauxin.


A synthesis of phytosphingosine from D-glucosamine.


Determination of amino acid sequences in oligopeptides by mass spectrometry. II. The structure of peptidolipin NA.


The mean QRS vector in myocardial infarction--its diagnostic value.


Transomatic vertebral angiography of the azygos vein in the diagnosis of portal hypertension syndromes.


Electron microscopy of capillary hemorrhage. I. Post hypoxemia hemorrhage in the lungs.


Electron microscopy of capillary hemorrhage. II. Capillary hemorrhage after mechanical impact.


The so-called basement membrane of the capillaries of the lung.


Further studies about the microbodies in the atria of the heart.


The 17-ketosteroid excretion of a healthy man on weekdays and weekends.


The influence of extracorporeal handling of blood on hemorrhagic shock in dogs.


A red-cell sensitizing antigen of group D streptococci.


Antigens in immunity. VII. Analysis of immunological memory.


Antigens in immunity. 8. Localization of 125-I-labelled antigens in the secondary response.


Formation of specific antibody by circulating cells.


A device for preparing cell spreads.

A device for preparing cell spreads.


Some interesting aspects of pleural effusion and ovarian cancer. (With report of case and hints on the use of lateral decubitus x-ray in diagnosis).


Electrophilic additions of acyl and sulfonyl halides to 2-ethoxypyridine 1-oxide. A new class of activated esters and their application to peptide synthesis.


The diterpene alkaloids. A study of the isomerization of iso-type diterpene alkaloid salts to normal-type salts.


The total syntheses of d,l-matrine and d,l-leontine.


Ichthyothereol and its acetate, the active polyacetylene constituents of Ichthyothere terminalis (Spreng.) Malme, a fish poison from the Lower Amazon.


Interaction and association of bases and nucleosides in aqueous solutions. IV. Proton magnetic resonance studies of the association of pyrimidine nucleosides and their interactions with purine.


The mitomycin antibiotics. Synthetic studies. IX. A versatile new method of indole synthesis.


The electronic structure and spectra of cis- and trans-stilbene.


7-Glycosylpurines. I. The synthesis of the anomeric 7-D-ribofuranosyladenines and the identification of the nucleoside from pseudovitamin B1-12.


A novel cleavage of the penicillin nucleus.


Rimocidin. I. Carbon skeleton, partial structure, and absolute configuration at C-27.


Benzhydryl esters of amino acids in peptide synthesis.


Nucleotides. IV. Conversion of ribonucleosides to new 2',3'-ketal derivatives.


Condensation of nitroethanol and ribose 5-phosphate. A novel route to sedoheptulose 7-phosphate.


A new synthesis of phosphatidic acids by direct acylation of DL-alpha-glycerophosphate.


Identification of compounds responsible for fruity flavor defect of experimental cheddar cheeses.


Substrate changes in peripheral nerve during ischaemia and Wallerian degeneration.


Report on the American Urological Association.


Mechanical factors in the production of hydronephrosis.


Calcified simple parenchymal cyst of the adrenal gland.


Reno-colic and reno-colic-cutaneous fistula: report of 3 cases.


The nature of peristalsis in ureters anastomosed to the skin.


Endarterectomy of a solitary kidney: recurrent hypertension 3 and one half years after nephrectomy.


Retroperitoneal ureteroileac revision.

Retroperitoneal ureteroileac revision.


Ileal loop diversion: evaluation of late results in pediatric urology.


A combined, continfous irrigator and tidal drainage apparatus for management of the postoperative bladder: a preliminary report.


Cutaneous vesicostomy as means of urinary diversion: 3 years experience.


Bladder evacuation by electrical stimulation of the rectum.


The rehabilitation of a defunctionalized bladder after sixteen years of inactivity.


Superimposition cystography in the diagnosis of infiltrating tumors of the bladder.


Rhabdomyosarcoma of the bladder in adult patients: report of three cases.


The role of infectious allergy in the genesis of certain relapsing migratory phlebitis. Therapeutic importance.


Polyethylene as Rumanian procedure for the polymerization of ethylene at low pressure with an amylsodium and titanium tetrachloride catalyzer.


Dedication address.

Dedication address.


Surgical correction of intractable blepharospasm. Technical improvements.


Ocular signposts to systemic diagnoses.

Ocular signposts to systemic diagnoses.


Surgical aphakia.

Surgical aphakia.


Pseudomonas infections of the rabbit cornea. Treated with gentamicin. A preliminary report.


The ocular manifestations of multiple sclerosis.


Intraocular penetration of methicillin.

Intraocular penetration of methicillin.


Circular fixed fold of the retina.

Circular fixed fold of the retina.


The eye in old age. V. Diseases of the macula: a clinicopathologic study.


Iridocyclectomy. A technique for removal of iris nelanomas.


Technique for cryothermic round-pupil cataract extraction. A preliminary report.


Normal human electroretinogram.

Normal human electroretinogram.


Contact lenses and corneal curvature changes.


Bilateral Duane's retraction syndrome.

Bilateral Duane's retraction syndrome.


Endophthalmitis phacoanaphylactica.

Endophthalmitis phacoanaphylactica.


A cryogenic probe for intravitreal surgery. A preliminary report.


A combined operation for cataract and glaucoma. A simple, adaptable, two-stage procedure for one operation.


Agenesis of three extraocular muscles. A case report.


Surgical management of a free-floating iris cyst in the anterior chamber.


New goniopuncture for buphthalmos.

New goniopuncture for buphthalmos.


Interruption of aortic arch; anatomic patterns and associated cardiac malformations.


Enlargement of optic foramen due to dermoid cyst of orbit.


Roentgenographic aspects of congenital left ventricular outflow tract obstruction.


Proximal interruption of a pulmonary artery.


Anomalous systemic arteries to the lung visualized by tomography.


Routine roentgenographic diagnosis of coarctation of the aorta in the child.


Postoperative aneurysm of the right ventricle.


Effect of respiration on venous return to the heart.


Amyloid heart disease.

Amyloid heart disease.


Coronary arteriography by the Sones technique. Technical considerations.


The significance of coronary calcification.


Visualization of abdominal aortic aneurysms.


Measurement of the abdominal aorta after intravenous aortography in health and arteriosclerotic peripheral vascular disease.


The use of selective angiography to study the effects of histamine on the dog's cardiovascular system.


Arteriographic manifestations of pancreatic neoplasm.


Congenital absence of the celiac axis trunk.


Compression of the celiac trunk and abdominal angina.


Carotid body tumors.

Carotid body tumors.


Cirsoid aneurysm of the uterus: specific arteriographic diagnosis; report of a case.


A catheterization gun for selective angiography.


Injection systems in angiography.

Injection systems in angiography.


Metabolic and chromosomal studies in leprechaunism.


Electroencephalographic studies in infants and children with hypothyroidism.


Observations on blood pressure in newborn infants.


Effect of penicillamine on serum iron.

Effect of penicillamine on serum iron.


E (16-18) trisomy syndrome: analysis of 13 cases.


Fatal haemolytic uraemic syndrome and idiopathic hyperlipaemia in monozygotic twins.


Head circumference of infants related to body weight.


Effect of blue light on hyperbilirubinaemia.


Mastocytosis. Report of a case in a 15 and one-half-week-old infant with cutaneous and generalized skeletal changes.


Accuracy of the sweat test: advantage of a micromethod.


Impact of engineering on public health.

Impact of engineering on public health.


Laryngeal stridor and respiratory obstruction associated with meningomyelocele.


The team approach--let's try it.

The team approach--let's try it.


Wanted: more men to live longer.

Wanted: more men to live longer.


Lower respiratory illness among Alaskan Eskimo children.


SO-2 effects on the respiratory system in dogs; changes in mechanical beahvior at different levels of the respiratory system during acute exposure to the gas.


DDT and DDE content of complete prepared meals.


Effects of cigarette smoke on respiratory function.


East African vs. American pancreatic and hepatic fibrosis.


Hepatic inflammation in narcotic addicts; viral hepatitis a possible cause.


Subacute dermal toxicity of 2,4-D.

Subacute dermal toxicity of 2,4-D.


Participation of industry in poison control.


Socioeconomic status and innocent heart murmurs.


The detergent dilemma.

The detergent dilemma.


Guide to the development of company medical policies.


Dermatitis venenata from lichens; biology of lichens related to criteria for diagnosis of occupational dermatitis and to industrial exposure risk.


Contaminated and natural lead environments of man.


Cellular pattern and nerve supply of the human organ of Corti; a preliminary report.


Middle ear muscle influence on binaural hearing.


A new treatment of Meniere's disease.

A new treatment of Meniere's disease.


Treatment of Meniere's disease with ultrasound; a follow-up on 117 cases using a new ultrasound appratus with an electronystagmographical analysis of the caloric reaction.


Spontaneous tympanoplasty.

Spontaneous tympanoplasty.


Biochemical studies of otosclerosis. 3. Lactic dehydrogenase in vein tissue.


Individual masking levels in pure tone audiometry.


Clinical evaluation of a "master hearing aid".


Cholesteatoma of the maxillary sinus; a case report.


Neck teratomas.

Neck teratomas.


Cervical teratoma in the newborn.

Cervical teratoma in the newborn.


Otitis media and complications.

Otitis media and complications.


Molecular structure determining the action of local anesthetics on the acetylcholine receptor.


Messenger RNA dependent synthesis of peptides by purified bacterial enzymes.


DNA-dependent incorporation of guanylate residues into polynucleotide material.


Some properties of poly-ribothymidylic acid, co-polymers of uridylic and ribothymidylic acids, and their 1:1 complexes with polyadenylic acid.


The relative ribonuclease-resistance of vitamin B12-binding ribosomes, a specific class within the ribosome population.


On the interaction of ribonuclease T-1 and guanosine 2'-phosphate and related compounds.


Effect of hypophysectomy on rat liver polyribosomes.


The metabolic conversion of L-glutamate to pyrrolidone carboxylate in rat tissues.


Endolysin from mutants of bacteriophage lambda.


Calculating air quality and its control.


Considerations in setting standards for oxides of nitrogen.


The clean air act and its implications for training requisite personnel.


Size distribution of sulfate aerosols in the ambient air.


Brush and trunk burning plant in the City of Detroit.


Community studies of the health effects of air pollution--a critique.


An evaluation of catalytic and direct fired afterburners for coffee and chicory roasting odors.


Industrial planning for air pollution control.


The biosynthesis in vivo of methylenebisphloroglucinol derivatives.


Synthesis of a peptide lactone related to vernamycin B-alpha.


Mass spectra of nucleic acid derivatives. Pyrimidines.


Glutarimide antibiotics. IX. The stereochemistry of the dihydrocycloheximides and the configuration of the hydroxyl group of cycloheximide.


Infrared and ultraviolet studies on the tautomeric equilibria in aqueous medium between monoanionic species of uracil, thymine, 5-fluorouracil, and other 2,4-diketopyrimidines.


Direct conversion of a nucleoside to an acid-labile 5'-O-alkoxyalkyl derivative.


Steroids. 283. Stereochemically controlled Simmons-Smith methylenation of homoallylic alcohols of low reactivity. A new synthesis of 10-alpha-testosterone.


The structures of the spiramycins and magnamycin.


The structure of magnamycin.

The structure of magnamycin.


The role of chelation in iron metabolism.


Biological aspects of the genesis of uterine tumours induced in mice by testosterone.


Reactions of the body to implanted materials.


The transformation in vivo of radioactive cortisol in normal humans.


The 17-alpha-hydroxy-C19-steroid dehydrogenase activity of ovine blood. Substrate specificity; effect of glucose on equilibrium constant.


Biosynthesis of progesterone by the human placenta.


Enterohepatic cycling of metabolized testosterone in the male dog.


Steroids in human peripheral blood of the menstrual cycle.


The presence of two interconvertible forms of 18-hydroxy-11-deoxycorticosterone.


Factors influencing the absorption of medroxyprogesterone acetate.


A comparison of the peripheral and central hemodynamic effects of regular and low molecular weight dextran in patients with ischemic limbs.


Roentgen hemodynamics in bilateral aortoiliofemoral arteriography by a unilateral percutaneous femoral artery needle injection.


Postoperative hypoxemia and its treatment with nasal oxygen: polarographic study.


The effect of bilateral supranodosal vagotomy on canine esophageal function.


Accelerated fatigue testing of available pacemaker electrodes and Elgiloy wire coils.


Pseudocyst of annular pancreas demonstrated by operative pancreatography.


Fundamentals of physiologic control of arterial hemorrhage.


The army artificial heart pump. II. Comparison of pulsatile and nonpulsatile flow.


Impervious visceral draping in the prevention of postoperative wound infection.


The importance of an adequate circulating blood volume following superior vena cava--right pulmonary artery anastomosis.


Neonatal arterial thrombosis and embolism.


Infantile hypertrophic pyloric stenosis.


The development of surgical procedures for the treatment of peptic ulceration of the stomach and duodenum.


Five years' clinical experience with an implantable pacemaker: an appraisal.


Preludes to Lister and the interdependence of the sciences.


D-E (13-15/17-18) translocation: occurrence in an infant with 45 chromosomes.


Effect of induced intrascrotal hyperthermia on testicular function in man.


The effect of an intrauterine contraceptive device on the histologic pattern of the endometrium.


Vaginal hysterectomy in patients less than 36 or more than 60 years of age.


The effects of clomiphene citrate on the endometrium.


Papillary ovarian tumors. II. Endometrioid cancers and mesonephroma ovarii.


Adenoma of the rete body.

Adenoma of the rete body.


Intrauterine contraceptive devices. A method of localization.


Monosaccharide content in placental polysaccharides of healthy pregnant women and toxemic women.


Effect of intrauterine fetal death on the maternal glucocorticoid excretion pattern.


Paraurethral gland adenocarcinoma.

Paraurethral gland adenocarcinoma.


Candidial vaginitis associated with the use of oral progestational agents. A clinical study was undertaken to assess the association between the use of oral progestational agents and the incidence of candidial vaginitis.  96 unselected females, all in their reproductive years, who presented with symptoms of vaginitis at the Gynecology Clinic of the University of Florida Teaching Hospital were used in the study.  24 of the women had used oral progestational agents; the remaining 72 had not.  Vaginal microbiological evaluation was carried out on all the women.  22 of the 24 women who had used oral progestagens showed heavy manifestations of Candida albicans.  All of these women also showed Lactobacillus species and 50% showed Trichomonas vaginalis as well.  Only 16.6% of the other group of women showed Candida albicans.  Percentages of women in the nonusage group also exhibiting the other 2 pathogenic organisms were also markedly lower.  So far, the literature has not noted a high incidence of monilial vaginitis associated with oral progestational use.  Results of this study highlight the need for further research.


Visualization of the placenta by radioisotope photoscanning using technetium-99m-labeled albumin.


Pancreatic secretion in vitro in "Cl-free," "Co-2-free," and low-Na+environment.


Primary resection and anastomosis in the treatment of perforated lesions of the colon.


Lymphadenotomography in cancer of the cervix.


Evaluation of a tuberculosis mass survey conducted in the city of Chatham and in Kent County, Ontario, in 1963. Computer analysis of the results of a mass tuberculosis survey of the population of Chatham city and Kent County, Ontario, was carried out to assess the efficacy of such surveys as a case-finding device. Six cases of active tuberculosis were found during the survey and approximately 50% of the 89,427 inhabitants of Chatham and Kent County were surveyed with radiographs and Heaf skin tests.A follow-up study of the Heaf test conducted in the public school of Wallaceburg detected 70 Heaf-positive children out of a total of 1190. These Heaf-positive children were further tested with a Mantoux test (5 T.U.) and chest radiography. Only 11 children of the original 70 were Mantoux-positive.These findings further support the hypothesis that the Heaf test, as now read, over-reads for M. tuberculosis infections.


Serum and urinary enzyme activity after renal infarction. Recently it has been observed that the activity of certain enzymes in serum and urine may be increased after renal infarction. Although aortography or selective renal angiography should be the diagnostic corner-stone on which one would proceed to embolectomy, it is possible that enzyme assays may serve as laboratory aids to suggest or confirm the diagnosis. This paper reviews the few existing clinical and experimental studies and reports on two patients who had a total of three episodes of renal infarction. Serial determinations after one episode showed increased activity of serum oxaloacetic glutamic transaminase (SGOT) and of lactic acid dehydrogenase (LDH) and alkaline phosphatase in the serum and urine; some elevated serum LDH and SGOT values were recorded after the other two infarctions. The time of onset and duration of these increases are discussed, and the possible difficulty in differentiating renal from myocardial infarction is illustrated.


The role of the faceguard in the production of flexion injuries to the cervical spine in football. The precise role of the single-bar face mask in producing major flexion violence to the cervical spine has been studied by review of game movies, analysis of the radiographs and detailed interviews with two players who sustained fractures of cervical spine. The single-bar face mask can become fixed in the ground, thereby forcing a runner's head down onto his chest as the trunk moves forward. Preventive measures embodying modifications in the face mask, strict coaching in football techniques and the institution of safety factors in the playing rules are proposed. Appreciation of the mechanism of injury is urged in order to encourage careful inspection of protective head gear as well as to direct the attention of team physicians to the possibility of serious flexion injury to the cervical spine occurring without dramatic evidence. This report is not a plea for abandonment of the face mask but rather a suggestion for careful selection of a safe and efficient mask.


Medicine in China.

Medicine in China.


Antidepressive drugs.

Antidepressive drugs.


Allescheria boydii--unique systemic dissemination to thyroid and brain.


Of sick cows and sick children.

Of sick cows and sick children.


Massive pulmonary embolism: successful surgical treatment using cardiopulmonary bypass.


The rebound phenomenon-fact or fancy? Experience with discontinuation of long-term anticoagulation therapy after myocardial infarction.


Mechanical hazards in catheter aortography.


Pressure gradients without obstruction. A new concept of "hypertrophic subaortic stenosis".


Symptomatic valvular myxomatous transformation (the floppy valve syndrome). A possible forme fruste of the Marfan syndrome.


Influence of a diet high in unsaturated fat upon composition of arterial tissue and atheromata in man.


Serum lactic dehydrogenase level as a diagnostic test for carditis in rheumatic fever.


Positive torque control cardiac catheters.


Limitations of hyperbaric oxygenation in occlusive arterial disease.


Work speed as a measure of an equivalent exercise stress in subjects of different weights.


Coronary calcification. Relationship to clinically significant coronary lesions and race, sex, and topographic distribution.


5 congenital cardiac defects. A study of the profile and natural history. Foreword.


Atrial septal defect--primum type.

Atrial septal defect--primum type.


Pulmonic stenosis.

Pulmonic stenosis.


Ventricular septal defect.

Ventricular septal defect.


Aortic stenosis.

Aortic stenosis.


6-Hemi-D-cystine-oxytocin, a diastereoisomer of the posterior pituitary hormone oxytocin.


Relationship of radioresistance and immunoresistance in an experimental tumour.


Rotenoids. XX. Total synthesis of rotenone.


The reaction of carbanions with N,S-diacetylcysteamine. A model for enzymatic carbon--carbon condensation.


Sense of helix of poly-L-histidine.

Sense of helix of poly-L-histidine.


Sulfur-containing polypeptides. I. Use of the N-benzhydryloxycarbonyl group and the benzhydryl ester.


2-D-tyrosine-oxytocin and 2-D-tyrosine-deamino-oxytocin diastereoisomers of oxytocin and deamino-oxytocin.


Effect of testosterone propionate on the urogenital organs of immature crocodile Crocodylus palustris Lesson.


The cotton effect associated with certain tyrosine residues in ribonuclease.


Determination of terminal sequences in viral and ribosomal ribonucleic acids.


The synthesis of spinochromes A, C, D, and E.


The anomeric linkage of streptose in streptomycin and bluensomycin.


Isotuboflavine and norisotuboflavine. Two new alkaloids isolated from Pleiocarpa mutica Benth.


Studies on nicotine biosynthesis.

Studies on nicotine biosynthesis.


Separation of nucleoside mixtures on Dowex-1 (OH-).


Biosynthesis of the Vinca alkaloids. I. Feeding experiments with tryptophan-2-C14 and acetate-1-C14.


6-Hemi-L-selenocystine-oxytocin and 1-deamino-6-hemi-L-selenocystine-oxytocin, highly potent isologs of oxytocin and 1-deamino-oxytocin.


Mixed metal complexes as enzyme models. I. Intracomplex nucleophilic catalysis by an oxime anion.


Ceanothine-B, a naturally occurring oxazacyclononadiene.


The use of the tyrocidines for the study of conformation and aggregation behavior.


Nucleophilic assistance in the acid-catalyzed reactions of acetals and glycosides.


A new L-alpha-amino acid from Lepidoptera.


Chlorinolysis of glycosidic bonds.

Chlorinolysis of glycosidic bonds.


Synthetic routes to emetine. Revised structure of a lactonic intermediate.


Some observations on magnesium in cerebrospinal fluid. Investigation of 67 patients with neurological disorders (excluding meningitis) showed a mean level of Mg in cerebrospinal fluid of 1.93 +/- 0.03 mEq./l. These figures are significantly lower than earlier figures published in the literature. Patients with polyradiculo-neuritis do not show the fall in cerebrospinal fluid Mg levels reported in cases of infective meningitis. The level of Mg in cerebrospinal fluid is maintained in the presence of low levels of plasma Mg.


Studies on infection and immunity in experimental typhoid fever. VI. Response of chimpanzees to endotoxin and the effect of tolerance on resistance to oral challenge.


Plasma concentration of renin in a patient with Conn's syndrome with fibrinoid lesions of the renal arterioles: the effect of treatment with spironolactone.


Paralysis associated with Plasmodium berghei malaria in the rat.


Biochemical studies of metabolic relationships in tularemia.


Recovery of a new syncytium virus from a cottontail rabbit.


Treatment of traumatized extremities with special consideration of the vascular problem.


Bilateral dissimilar renal lesions as a source of reversible hypertension: a case report.


Carcinoma of the lip.

Carcinoma of the lip.


The ultrastructure of neointima of aortic fabric grafts in dogs.


Alpha-chymotrypsin in juvenile and congenital cataracts.


Clinical importance of pancreatic heterotopia.


Results of surgical treatment of stenosis of the sphincter of oddi.


Reconstructive surgery of obstructing lesions in the supra-aortic branches.


On the treatment of sponatneous pneumothorax.


A new method for demonstrating fistulas of the soft tissues.


Adhesion and granuloma inducing capacity of glove powders in the abdominal cavity.


Factors influencing survival after radical operation for gastric cancer.


Advantages of open and closed chest resuscitation.


A new surgical philosophy comes to life.


Mannitol diuresis: the relationship of plasma volume to renal blood flow.


Evaluation of pharmacologically induced renal vasodilatation.


Respiratory influences on the secretion of catecholamines.


A comparison of WAIS, Binet, and WISC test. Results of mentally retarded young adults born in New York City and Puerto Rico.


The relationship between reading and anxiety in a group of mental retardates.


Peabody Picture Vocabulary Test as a measure of intelligence for mentally subnormal children.


Experiments with a latex-slide test for the serodiagnosis of trichinosis. (Preliminary report).


Experimental comparison of "parallel grid leads" with simple bipolar, and the SVEC-3, Frank, and McFee-Parungao systems. II. Transverse and vertical leads.


Suicidal attempt by overdosage of ajmaline.


Psychiatric morbidity among students.

Psychiatric morbidity among students.


Arterial pressure and arm circumference.


Public and professional attitudes to a screening programme for the prevention of cancer of the uterine cervix. A preliminary study.


Socio-medical study of enuresis among delinquent boys.


Tradition in transition. A health opinion survey in Ibadan, Nigeria.


Multiple spells of in-patient treatment in a calendar year.


The mechanism of plasma albumin loss in carcinoma of the cecum. Investigation of hypoalbuminemia in an elderly woman with a large papillary adenocarcinoma of the cecum revealed that the hypoproteinemia was due to excessive loss of plasma albumin into the intestinal tract. Results of studies on this patient and analysis of published reports suggest that several factors were involved in the loss of albumin from the neoplasm, namely, the size and location of the tumour, absence of normal surface epithelium, presence of exudate on the surface of the tumour due to tumour necrosis and secondary infection, and bleeding from damaged vessels near the surface of the tumour.


Posterior tibial tenosynovitis secondary to foot strain.


Nonunion of malleolar fractures of the ankle.


Complications of the operative treatment of fractures of the ankle.


Atlanto-axial dislocation with odontoid separation in rheumatoid disease.


Measly muscle (Taenia solium in striated muscle).


Dilatation of the common iliac vein and the inferior vena cava in spondylolisthesis. Report of a case with reference to 3 other cases.


Single motor unit action potentials.

Single motor unit action potentials.


To refer and to consult. Psychiatric referrals of adolescent patients.


Subtalar extra-articular arthrodesis. Follow-up study.


Early traumatic pseudoaneurysm of the medial femoral circumflex artery due to the blind use of an osteotome.


Cross infection on a pediatric contagion unit. A program for control.


The initial postmortem biochemical changes that occur in epiphyseal cartilage.


Dysmelia and its management. Habilitation of children with servere limb deformities presents a great challenge.


Fracture about the ankle joint with fixed displacement of the proximal fragment of the fibula behind the tibia.


Roentgenological findings in congenital rubella.


Fractures of the ankle. A clinical survey of 181 cases.


Disorders of amino acid metabolism. Recent advances.


Spontaneous pneumothorax in the newborn.


The operative treatment of fracture-dislocation of the ankle joint.


Clinical notes on the management of asthma and eczema. When to call the psychiatrist.


The Waardenburg syndrome. Description and report of a search.


Ankle joints of freshmen college athletes.


Surgery and sprained ankles (lateral ligament tears).


Fractures of the ankle involving the lower articular surface of the tibia.


Ankle joint fractures and their treatment.


Effects of natural and synthetic corticoids on transfusional shock in the rat.


Blood group antigens and cross-reacting antibodies in primates including man. V. Production of antisera for a "new" blood factor V-1 by immunization of chimpanzees with human blood.


Outward rotation-supination injuries of the ankle.


Extensive giant-cell tumor of the lower end of the radius. A report of 1 case treated by resection and replacement with the fibula.


Nuclear magnetic resonance studies of methyl derivatives of cytosine.


The total synthesis of dihydrocostunolide.


The role of substituents in the hydrophobic bonding of phenols by serum and mitochondrial proteins.


Studies of the mechanism of biotin catalysis.


Isolation and characterization of anthramycin, a new antitumor antibiotic.


The structure of anthramycin.

The structure of anthramycin.


Dietary survey in rural Lebanon. II.

Dietary survey in rural Lebanon. II.


The isolation and structural elucidation of a novel steroidal tumor inhibitor from Acnistus arborescens.


Working with Pueblo Indians in New Mexico.


Proximate composition of ready-to-serve, rice-containing foods.


Pioneer in Peru.

Pioneer in Peru.


The treatment of bronchial asthma by means of hypnosis as viewed by the allergist.


Fluoridation and the allergist.

Fluoridation and the allergist.


Intractable asthma and hostile identification, imprinting in humans, and autonomic mechanisms.


Perennial nasal allergy due to food sensitization.


Air pollution and asthma.

Air pollution and asthma.


Epidemiological aspects of the use of pesticides in the South.


Examination and selection of personnel for work in underwater environment.


A practical, quantitative method for assessing the psychological environment of children. A study of 392 boys 6 to 14 years of age.


Factors contributing to severity of herpes zoster in children.


Bacterial endocarditis due to corynebacterium. Report of 2 cases.


Cor pulmonale in cystic fibrosis of the pancreas.


The effects of ligation of the subclavian artery on the bones and soft tissues of the arms.


Urea and electrolyte levels in the serum in sclerema neonatorum.


Epidermolysis bullosa hereditaria simplex. A kindred affected in 4 generations.


Pelger-Huët anomaly of the granulocytes in a Cape colored family.


The new United States Pharmacopeia (XVII) and National Formulary (XII): new and vital changes for children.


Congenital cystic adenomatoid malformation of the lung.


Pancarditis, probably rheumatic, in association with sickle cell disease.


The radiologic phenotype of the D1 trisomy syndrome. Abnormalities of the ribs and pelvis.


Probable 3/13-15 chromosome translocation with D1 trisomy syndrome.


Clinical pathological conference. The Children's Hospital Medical Center Boston, Mass.


Rat-bite fever.

Rat-bite fever.


One hundred cases of treatment for Adams-Stokes syndrome with permanent intravenous pacemaker.


Anomalous origin of the right pulmonary artery from the ascending aorta.


Supravalvular aortic stenosis.

Supravalvular aortic stenosis.


Rupture of the thoracic trachea with avulsion of the apex of the right upper lobe.


Aneurysm of the left pulmonary artery with hemoptysis and bronchial obstruction.


Role of citrate in abnormal copper metabolism.


Evaluation of an epinephrine test in obesity.


Dynamics of plasma triglyceride turnover in man.


Effects of experimentally induced intoxication on metabolism of ethanol-1-C-14 in alcoholic subjects.


Uric acid excretion and ketosis in fasting.


Effect of chlorpropamide on phlorhizin glycosuria.


Detection of 21-deoxycortisol in blood from a patient with congenital adrenal hyperplasia.


Effects of insulin on triglyceride and free fatty acid metabolism in man.


The effect of thiazides on the blood sugar of alloxanized and suballoxanized rats.


Stool losses and acidosis in diarrheal disease of infancy.


Phyco-periphyton in an oligotrophic lake.


On the life cycle of the trematode Prosthogonimus cuneatus (Rudolphi, 1809) (Plagiorchidae) in Egypt.


Variability in Australorbis glabratus (Say).


An easily constructed microculture chamber.


Adaptation to open heart surgery: a psychiatric study of response to the threat of death.


Desipramine and imipramine in an outpatient setting: a comparative study.


The maximal midexpiratory flow: a re-examination.


Significance of lactate and pyruvate according to volume of blood transfusion in man: effect of exogenous bicarbonate buffer on lacticacidemia.


Common bile duct motility and sphincter mechanism. I. Pressure measurements with multiple-lumen catheter in dogs.


A trial myocardium transplanted in right ventricle: growth, histologic alterations and mechanical properties after 21 months.


Comparison of instrumentation for experimental and clinical gastric freezing.


Effect of gastric, extragastric and truncal vagotomy on the external secretion of the pancreas in the dog.


Spinal cord ischemia following mobilization canine aorta from posterior parietes.


Surgical correction of tuberculous pseudoaneurysm of upper abdominal aorta: first reported case.


Congenital lobar obstructive emphysema. Report of eight cases and literature review.


Mastoplasty for massive bilateral benign breast hypertrophy associated with pregnancy: case report.


Congenital anal stenosis with presacral teratoma: case reports.


Excision of taenia coli for repair of esophagocolic stricture following colon transplant: case report.


Role of hepatic arterial blood flow and hepatic nerves on renal circulation and function. II. Chronic studies in the dog.


Influence of thoracotomy on pulmonary mechanics: association of increased work of breathing during anesthesia and postoperative pulmonary complications.


Gastric ulcer: classification, blood group characteristics, secretion patterns and pathogenesis.


An electron microscopic study of the nevic corpuscle.


The synthesis of macroglobulin antibody to a bacterial antigen in mice after treatment with thorotrast.


Localization of particulate carbon in metaphyseal vessels of growing rats.


Effects of hyperkalaemia upon the general and coronary haemodynamics of the dog.


An economical bioassay bath for isolated tissues.


Recoveries of Strigomonas oncopelti, Leptospirae and Reiter's treponeme from desiccates after storage for five years.


"Are hospitals good employers"?

"Are hospitals good employers"?


Some effects of "Medicare" on hospitals in Saskatchewan.


Administrator must promote kitchen sanitation.


Synthesis of (+ or -) -cis-1-O-n-hexadec-1'-enylglycerol and its structural identity with the hexadecenylglycerol from plasmalogen.


Synthesis of 9-(beta-D-lyxofuranosyl)adenine.


Volatile flavour constituents in coconut oil.


Brain cholesterol. XI. A review of biosynthesis in adult mice.


Cholesterol turnover in the central nervous system.


Investigation of the biogenetic reaction sequence of cholesterol in rat tissues, through inhibition with AY-9944.


Application of computer methods to the calculation of triglyceride structure.


The turnover of the lipid components of myelin.


Structure of the intestinal mucosa and lymph glycerides of rats after absorption of fats containing elaidic acid.


Production of microbial lipases for the study of triglyceride structure.


The unsolved problems of triglyceride analysis.


The triglycerides of sable fish (Anaplopoma fimbria). II. Fatty acid distribution in triglyceride fractions as determined with pancreatic lipase.


Solidification of unsaturated/saturated fatty acid mixtures and its relationship to chilling sensitivity in plants.


Relation of triglycerides to phosphoglycerides in fungi.


Detection of trace fatty acids in fats and oils by urea fractionation and gas-liquid chromatography.


Phase behavior of aqueous systems of monoglycerides.


A comparison of nuclear magnetic resonance and dilatometry for estimating solids content of fats and shortenings.


Further observations on the dicarbonyl compounds formed via autoxidation of methyl linoleate.


The oxygenated fatty acid of Calendula seed oil.


Salts of alkyl esters of a-sulfopalmitic and a-sulfostearic acids.


Ultraviolet spectroscopic analysis for following the biodegradation of hydrotropes.


Production of cyclic fatty acids: water as the reaction solvent.


Volatile products from mild oxidation of methyl linoleate. Analysis by combined mass spectrometry-gas chromatography.


The effect of kind of dietary carbohydrate upon the composition of liver fatty acids of the rat.


Competitive inhibitions in the metabolism of polyunsaturated fatty acids studied via the composition of phospholipids, triglycerides and cholesteryl esters of rat tissues.


The metabolic fate of fatty acids derived from dietary triglycerides.


Direct application of serum to thin-layer plates for rapid determination of serum lipids.


Dietary fatty acids: their metabolic fate and influence on fatty acid biosynthesis.


Hydrogenation of linolenate. XII. Effect of solvents on selectivity.


Fatty acids of bovine milk glycolipids and phospholipids and their specific distribution in the diacylglycerophospholipids.


Dietary myristate and plasma cholesterol concentration.


Radioimmunologic measurement of human placental lactogen in plasma by a double antibody method during normal and diabetic pregnancies.


Separation of follicle stimulating and luteinizing hormones from urine of eunuchs.


Metabolic studies of human bone in vitro. I. Normal bone.


Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man.


A study of the effect of reserpine on thyroid secretion in several mammalian species.


Genetic variation in diuretic responses to water loads: definition of some parameters of diuretic response and initial results of selection for these parameters.


Thyroidal adjustment to the iodine environment.


Insulin sensitivity and carbohydrate metabolism of rats with hypothalamic obesity.


A biological assay for calcitonin.

A biological assay for calcitonin.


The specific activity of plasma cortisol in sheep after rapid intravenous injection of [1,2-3H2]cortisol, and its relation to the rate of cortisol secretion.


Oral and intravenous suppression tests in the diagnosis of Cushing's syndrome.


On single 'hot' nodules of the thyroid gland.


Formation of 15-alpha-hydroxyoestradiol-17-beta and 18-hydroxyoestrone by human adrenal tissue.


The effect of D2-O on the thermal stability of proteins. Thermodynamic parameters for the transfer of model compounds from H2-O to D2-O.


Long-term evaluation of ischiectomy in the treatment of pressure ulcers.


Ulnar artery thrombosis in the palm. Case reports.


Calcinosis circumscripta. Report of a case involving the hands.


Venous air embolism during operations on the head and neck. Report of a case.


Expanding forearm hematoma after apparent minor injury.


The bifid nose. With a report of 3 cases in siblings.


Siliconoma--another cutaneous response to dimethylpolysiloxane. Experimental study in mice.


A point of surgical technique: effective adhesive bridging.


Incompetence of the sphincter of Oddi in the newborn.


The effect of gastric secretagogues on gastric tissue histamine.


Examination of the gastric fundus with the fibergastroscope. Report of a new technic.


Obstructive cholecystopathy or primary roentgenographic shadow of the gallbladder. Report on 262 patients.


Gastric polyps.

Gastric polyps.


Hypogammaglobulinemia and steatorrhea.

Hypogammaglobulinemia and steatorrhea.


The pedunculated adenomatous polyp.

The pedunculated adenomatous polyp.


The problem of anicteric hepatitis.

The problem of anicteric hepatitis.


Intestinal villous motility and its regulation.


Surgical diseases of the adrenal glands.


The effect of hydrocortisone on acid secretion in the chronic gastric fistula rat.


Gastric motility in the dog: distinctive activity of the subcardiac zone of the stomach.


Amebic liver abscess. Needle aspiration and air replacement.


Papillomatosis of the gallbladder. Report of a case with intermittent jaundice and pain.


Small bowel obstruction following anticoagulant therapy. Report of a case and review of the literature.


Evidence for a new plasma thromboplastin factor. I. Case report, coagulation studies and physicochemical properties.


Effect of heparin upon various forms of the thrombohemorrhagic phenomenon (THP).


Intravascular activation of the clotting system with phospholipids. Production of the generalized Shwartzman reaction with platelet factor 3.


An assay for the mitogenic activity of phytohemagglutinin preparations.


The mitotic activity of circulating atypical mononuclear cells in infectious mononucleosis.


An epidemiological study of polycythemia vera.


Two delta-chain abnormal hemoglobins in one individual.


Protein metabolism in Tetrahymena pyriformis cells dividing synchronously under starvation conditions.


Barbiturate mortality as an index barbiturate use, Canada, 1950-1963. Changes in Canadian rates of mortality from barbiturates are examined, and their relation to barbiturate use in the general population is discussed. While the number of deaths attributed to barbiturates quadrupled, from 63 in 1950 to 232 in 1963, there has been a concomitant decrease in the number of deaths from inhalation of utility gas.Combined rates for deaths from utility gas and barbiturates declined steadily for most age groups between 1950-52, 1955-57, and 1959-63. It is possible that the increased mortality from barbiturates represents a change in fashion in regard to method of suicide. Changed mortality from barbiturates is not a valid measure of the extent to which consumption of barbiturates has increased in the Canadian population.


Vectorcardiographic evaluation of postoperative changes in patients with interatrial septal defect: a review of 55 cases. The pre- and post-operative vectorcardiograms of 55 patients with atrial septal defect (ASD) are discussed. Forty-nine were of ostium secundum type and six of ostium primum type. The criteria used to study the regression of right ventricular hypertrophy were: in the horizontal plane, the ratio of anterior-over-posterior forces, the right-over-left forces and the rotation of the body of the QRS loop; in the frontal plane, the direction of half-area vector. Using these criteria, 46 out of 49 patients with defects of the ostium secundum type had vectorcardiographic evidence of regression of right ventricular hypertrophy. Marked clinical improvement was also demonstrated in all these patients. The three patients in whom improvement was not demonstrated on the vectorcardiogram had persistence of a cardiac defect. Following surgery two children with ostium primum defects showed no change in the frontal plane, whereas in the horizontal plane a normalization of vectorial forces was observed.


Femoral hernia in the female.

Femoral hernia in the female. A study of 384 consecutive femoral herniorrhaphies performed upon female patients admitted to Shouldice Hospital, Toronto, during a 19-year period was carried out. Its main purpose was to describe the techniques used and to evaluate the results obtained. A careful 10-year follow-up plan for all cases existed.Two hundred and ninety-three operations were performed for the repair of simple femoral hernia; 91 were performed for the repair of femoral hernia which had developed following an initial ipsilateral inguinal or femoral repair performed previously, either in this hospital or elsewhere.The basic repair was subinguinal. Four modifications are described, one entirely subinguinal and three combined with exploration of the inguinal canal.The recurrence rate for simple femoral hernia in the female was 1.3% and for "recurrent" femoral hernia in the female, 5.5%.


Malignant melanoma and dermatomyositis.

Malignant melanoma and dermatomyositis.


Treatment of malignant melanoma by regional perfusion.


Hormone therapy for advanced breast cancer.


Castration in the treatment of advanced breast cancer.


Chemotherapy in childhood cancer (except leukemia). An appraisal.


Nature and examples of joint clinical studies.


Squamous carcinoma in situ of the uterine cervix. 3. A long-term follow-up of 23 unsuspected cases of 6- to 10-year duration without interim treatment.


American Joint Committee on Cancer Staging and end results reporting. Objectives and progress.


Primary malignant melanoma of the tongue. A case report and review of the literature.


Cryotherapy for cancer of the lip and oral cavity.


Ciliatoxic components in cigarette smoke. 3. In vitro comparison of different smoke components.


Electronic bladder stimulation: dog and human experiments.


Combined physiologic and radiologic studies of bladder function in female children with recurrent urinary tract infections.


Crystallization concepts and calculogenesis: observations on artificial oxalate concretions.


The role of lysine residues in the activity of 2-keto-3-deoxy-6-phosphogluconate aldolase.


Rat skeletal muscle hexokinase. I. Kinetics and reaction mechanism.


The biosynthesis of D-glucose 1,6-diphosphate from D-glucose monophosphates in rat liver. Dependence of the reaction on phosphoglycerate.


Studies of the acetyl coenzyme A synthetase reaction. II. Crystalline acetyl coenzyme A synthetase.


Studies of the acetyl coenzyme A synthetase reaction. 3. Evidence of a double requirement for divalent cations.


Isolation of a large polypeptide from bovine posterior pituitary powder.


The effect of glycerol 3-phosphate on fatty acid synthesis.


Structure of a large polypeptide of bovine posterior pituitary tissue.


The comparative enzymology of lactic dehydrogenases. IV. Function of sulfhydryl groups in lactic dehydrogenases and the sequence around the essential group.


Kinetics of the reaction of alpha-chymotrypsin with diisopropyl fluorophosphate, with measurements of hydrogen ion release, enzyme inhibition, and spectral changes of enzyme at 290 mu.


Binding of indole analogues to human serum albumin. Effects of fatty acids.


Cellular lipoproteins. I. The isolation of lipoprotein fractions from cellular mitochondria and microsomes.


Transamidinase of hog kidney. 3. Effect of bicarbonate on the enzyme-amidine complex.


Pituitary peptides. Isolation of new peptides related to beta-melanocyte-stimulating hormone.


Properties of the soluble product obtained from reoxidation of reduced fragment I from rabbit 7S gamma-immunoglobulin.


Preparation of crystalline erythrocuprein and catalase from human erythrocytes.


Physicochemical studies of crystalline human erythrocuprein.


Temperature jump studies of sperm whale metmyoglobin. II. Azide and cyanate binding by metmyoglobin.


N-formimino-L-glutamate formiminohydrolase of Aerobacter aerogenes.


Imidazolepropionate, a nonmetabolizable inducer for the histidine-degrading enzymes in Aerobacter aerogenes.


Induction and repression of the histidine-degrading enzymes in Aerobacter aerogenes.


Exogenous and endogenous induction of the histidine-degrading enzymes in Aerobacter aerogenes.


Thyroidal biosynthesis of iodothyronines. I. General characteristics and distribution of the bovine enzyme system.


Enzymatic deamination of delta-1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (alpha-ketoglutaric semialdehyde).


Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline.


Thermodynamic data for the secondary phosphate ionizations of adenosine, guanosine, inosine, cytidine, and uridine nucleotides and triphosphate.


Stimulation of hepatic purine biosynthesis by orotic acid.


Nonterminal incorporation of guanosine monophosphate from guanosine triphosphate by an enzyme system from spinach chloroplasts.


Studies of phosphorus metabolism by isolated nuclei. VII. Identification of polyphosphate as a product.


Enzymatic synthesis of the pteridine moiety of dihydrofolate from guanine nucleotides.


Tryptophan in the active site of rhodanese.


Effect of 8-azaguanine on phosphorylation of purines in Astasia and Euglena.


The isolation of three sugar dehydrogenases from a psuedomonad.


Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad.


Some physical properties of three sugar dehydrogenases from a pseudomonad.


Studies on cytochrome c peroxidase. I. Purification and some properties.


Studies on cytochrome c peroxidase. II. Stoichiometry between enzyme, H2O2, and ferrocytochrome c and enzymic determination of extinction coefficients of cytochrome c.


The effect of vasopressin and of theophylline on the concentration of adenosine 3',5'-phosphate in the urinary bladder of the toad.


Compartmentation of heart mitochondria. I. Permeability characteristics of isolated beef heart mitochondria.


Identification of the diketopiperazine of histidylproline in human urine.


Comparative haptoglobin binding properties of oxyhemoglobin and deoxyhemoglobin.


Evidence for disulfide cross-linkages in an invertebrate collagen.


Comparison of theories of the helix-coil transition in polypeptides.


Statistical thermodynamic theory for helix-coil transitions involving poly- and oligonucleotides. II. The case of partial binding.


On the nonlinear dielectric behavior of desoxyribonucleic acid fibers at low frequencies.


Metabolism and maternofetal transfer of human growth hormone in the pregnant woman at term.


Pseudohypoparathyroidism and bone demineralization: case report and metabolic studies.


Determination of progesterone in human peripheral blood using gas-liquid chromatography with electron capture detection.


Endocrine studies at high altitude. II. Adrenal cortical function in sea level natives exposed to high altitudes (4300 metersfor two weeks.


Aldosterone secretion rates in abnormal pregnancy.


Primary role of plasma hydrocortisone concentration in the regulation of the normal forenoon pattern of urinary phosphate excretion.


Epitestosterone: an in vitro metabolite of delta-4-androstenedione in a sclerocystic ovary.


Antagonism between adrenal steroids and parathyroid hormone.


The immunoglobulins of mice. VI. Response to immunization.


Synthetic polypeptide metabolism. I. The metabolic fate of enantiomorphic polymers.


Synthetic polypeptide metabolism. II. The binding of synthetic polypeptides to serum proteins.


Attempts to induce early-type ("Jones-Mote") delayed hypersensitivity in mice.


Studies in immunization. 3. The use of beryllium as a granuloma-producing agent in Freund's adjuvant.


Properties of papain-digested chicken 7 S gamma-globulin.


A study of phase variation in Coxiella burneti employing hemagglutination tests.


The nature of antibodies synthesized during the immune response to Leptospira biflexa.


Dissolution kinetics of certain crystalline forms of prednisolone.


Effect of adsorbents on drug absorption. I. Modification of promazine absorption by activated attapulgite and activated charcoal.


Urinary excretion of d-propoxyphene hydrochloride in man.


Chemistry of some 3-benzoylpiperidines.

Chemistry of some 3-benzoylpiperidines.


Determination of tetracycline antibiotics by alternating-current polarography.


Oxidation of aldehydes solubilized in nonionic surfactants. II. Oxidation of benzaldehyde and methylbenzaldehyde in aqueous solutions of polyoxyethylene glycol ethers.


Application of Mannich reaction to sulfones II. Role of aromatic aldehydes in condensation.


Effect of particle size on gastrointestinal absorption of sulfisoxazole in dogs.


Segregation kinetics of particulate solids systems. 3. Dependence on agitation intensity.


Effects of combining selected inhibitors of influenza virus replication in tissue culture.


Evaluation and mechanism of action of two hypotensive substituted diamines.


Interactions of xanthine derivatives with bovine serum albumin. II. Spectrophotometric studies.