Management of chronic renal failure.

Management of chronic renal failure. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California Medical Center, San Francisco. Taken from transcriptions, they are prepared by Drs. Martin J. Cline and Hibbard E Williams, Assistant Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.


Glutethimide intoxication with prolonged coma and hyperpyrexia treated with methylphenidate.


Public health report.

Public health report.


Sources of income and principal employers of California physicians, August 1965. A report of the Bureau of Research and Planning, California Medical Association. As of August 1965, 54.4 per cent of the 31,551 California physicians in active practice indicated that they receive all of their income from fees-for-service, with another 7.9 per cent receiving at least some of their income in this manner. A total of 8,025 M.D.'s, or 25.4 per cent, are on full-time salaries with no other source of professional income, and the remaining 12.2 per cent are members of group practices, whether on an income sharing or a salaried basis. Almost two-thirds of California physicians (66.6 per cent) consider themselves to be primarily self-employed. Of the 21,011 self-employed physicians, 76.3 per cent are in individual practice, 10.5 per cent in partnerships or groups (without income-sharing arrangements) and the remaining 13.2 per cent in group practice (income-sharing). Slightly over one-fifth of all salaried physicians are employed by some Federal agency, primarily in the armed forces. Among the other four-fifths, more than half are hospital employees, with most of the remainder working for other physicians, clinics or educational institutions. General Practice remains the most heavily populated specialty in California, accounting for 26.3 per cent of all physicians; among self-employed physicians only, G.P.'s number more than one out of every three physicians, or 34.6 per cent. Internists, General Surgeons, Psychiatrists and Obstetrician-Gynecologists rank next in order among all physicians; however, the positions of Psychiatrists and OB.'s is reversed among self-employed physicians.


Cancer of the larynx; results of surgical and radiological treatment in one institution. Of 67 consecutive patients with cancer of the larynx seen at the San Francisco General Hospital from 1948-1960 inclusive, 25 were treated primarily by radical radiotherapy and 31 by radical surgical operation. Of the 25 treated by radiotherapy (with surgery for failure in three instances) 13 apparently had arrest of disease and nine of these remained cured five or more years. Four died of intercurrent disease. Of the 31 treated primarily by radical operation (with subsequent radiation for surgical failure in 11 patients), 13 had potential arrest of disease and seven of the 13 remained cured for five or more years. Six died of intercurrent disease before the lapse of five years, three of them within four weeks of radical operation. Radical radiotherapy of laryngeal cancer produced results superior to those of radical surgery in patients seen and treated during the period under review in this hospital.


Differentiation of dysfunction from rpture of papillary muscle.


Serological investigation on endemicity of poliomyelitis in Calcutta and in a neighbouring rural area.


Some further electron microscopic observations on cholera bacteriophages.


Histologic diagnosis of species of fungus causing mycetoma.


Studies on the effect of combined therapy of anabolic hormone and ascorbic acid in the treatment of fractures.


The acute toxicity of some heavy metals to different species of warmwater fishes.


The sexing of the adult clavicles.

The sexing of the adult clavicles.


An experimental study of heterograft replacement of major vessels in dogs.


Effect of chronic midbrain lesions on stress corticosteroid level.


Newer concepts in the therapy of cardiogenic shock.


Parathyroid function in endemic fluorosis.


A study of anti-inflammatory activity of some indigenous drugs in albino rats.


The case of the helical haloes.

The case of the helical haloes.


Fluphenazine for the treatment of patients with anxiety.


Ependymoma of the fourth ventricle.

Ependymoma of the fourth ventricle.


Paroxysmal atrial tachycardia (PAT) with block (7). Effect of potassium.


Asthma: immunological and non-immunological.


Effects of prolonged ingestion of glucose or ethanol on tissue lipid composition and lipid biosynthesis in rat. The effects on lipid metabolism of long-term feeding of large amounts of ethanol or glucose differed from those that have been reported in short-term experiments. Three groups of male rats were investigated. The first was fed lab chow and 15% (v/v) ethanol ad lib.; the second was pair-fed with the first and given isocaloric amounts of glucose in lieu of ethanol; the third was fed lab chow and water ad lib. All three groups consumed nearly the same number of calories, and about 30% of the calories in the first group were derived from ethanol. Neither glucose nor ethanol added to a nutritionally adequate diet promoted the development of a fatty liver, although both stimulated acetate-(14)C utilization for hepatic lipid synthesis. In all three groups more than 80% of the label in hepatic lipid was found in fatty acids, and the distribution of label amongst the fatty acids of different chain lengths was virtually the same. Ethanol decreased while glucose increased the quantity of lipid in fat depots, and each altered the fatty acid composition of the lipids in adipose tissue, kidney, liver, and hepatic subcellular fractions in a different manner. The most striking of these changes was the relative increase in monounsaturated fatty acids and the decrease in essential fatty acids produced by glucose.


Effects of prolonged ingestion of glucose or ethanol on fatty acid synthesis by mitochondria and cell sap of rat liver and adipose tissue. Effects of prolonged ingestion of glucose and ethanol on the rate of fatty acid synthesis by liver and adipose tissue have been investigated in male rats. Ethanol significantly enhanced the rate of fatty acid synthesis from malonyl-2-(14)C CoA in liver cell sap; glucose feeding enhanced the rate of fatty acid synthesis from both malonyl-2-(14)C and acetyl-1-(14)C CoA. Neither dietary supplement modified the types of fatty acid synthesized in this enzyme system. Palmitic acid was the principal product synthesized from a mixture of malonyl and acetyl CoA, whereas myristic and palmitic acids were the predominant products formed from acetyl CoA alone. Neither glucose nor ethanol affected fatty acid synthesis by adipose tissue cell sap. Mitochondria derived from liver and adipose tissue of control, glucose-fed, and ethanol-fed animals all incorporated acetyl-1-(14)C CoA into lipid at about the same rate, but did not utilize malonyl CoA for lipid synthesis to any significant degree. The label appeared in fatty acids, one-half of which were contained in phospholipid. Both unsaturated and saturated fatty acids synthesized by mitochondria contained isotope, most of which was present in the carboxyl groups. Ethanol and glucose feeding stimulated the labeling of monoenoic fatty acids in liver mitochondria, but only glucose did so for adipose tissue. These findings agree with results previously obtained when lipogenesis was measured with acetate-(14)C in vivo.


Movement of lipids into and out of the blood during hyperlipidemia induced in rabbits by pituitary extract and fraction H. Rabbits were rendered hyperlipidemic by the subcutaneous injection of an alkaline aqueous extract of mammalian pituitary gland or a partially purified, concentrated fraction derived therefrom, designated Fraction H. Eight hours after the injection of Fraction H, arteriovenous (A-V) differences in plasma triglyceride (TG) were measured across five body areas. A large negative A-V difference in plasma TG was consistently found across the liver (increase in plasma concentration), and a moderate positive A-V difference across the perirenal fat depot (decrease in plasma concentration). Most values obtained across the intestines and mesentery and the leg were positive. Differences across the kidney were mostly small and almost equally divided between positive and negative values. Similar results were obtained 7-12 and 16-18 hr after injection of the pituitary extract. It is concluded that the liver is the principal source of the TG for this kind of hyperlipidemia, and that the plasma TG levels are reduced principally in passage through adipose tissue. A consistent negative A-V difference in plasma free fatty acid concentration (net increase) was found across the kidney 7-12 hr after injection, suggesting that the kidney hydrolyzes its accumulated TG and mobilizes it in the form of free fatty acids.


Lipid transfer between human serum high density lipoproteins and egg yolk lipoproteins in incubation mixtures. Ultracentrifugally isolated human serum high density lipoproteins of d 1.063-1.21 (HDL) were incubated with egg yolk lipoproteins of d < 1.006 for up to 24 hr at various concentrations. Transfer of HDL cholesterol esters to egg yolk lipoproteins occurred simultaneously with transfer of glycerides from egg yolk lipoproteins to HDL. These observations show that exchange of lipids can take place between lipoproteins in the absence of other serum proteins and enzymes. The mole ratios of HDL cholesterol esters to glycerides approached an integral value of 1 : 1 during the course of the incubation. These results suggest that lipid components form complexes within the HDL structure.


Incorporation of acetate-1-14C into lipids by the perfused liver of normal, X-irradiated, or partially hepatectomized rats. In order to study lipid metabolism in the liver without interference due to transport from and to the liver the isolated livers of normal, X-irradiated, and partially hepatectomized rats were perfused with acetate-1-(14)C and the distribution of radioactivity in total lipids, total fatty acids, individual lipids, and fatty acids of individual lipids was determined. In X-irradiated animals, an increased incorporation of acetate into many lipids, particularly into cholesterol, was observed. Lipids in the liver of the partially hepatectomized rats exhibited a marked increase in triglyceride content together with a decreased rate of incorporation into all but the phospholipid fractions. It is concluded that the increase usually observed in lipid pontent of the regenerating liver is due to the changes in transcort rather than to changes in synthesis. The changes observed in irradiated liver could be the result of alterations in the metabolism of precursors common to most lipids.


Absorption, transport, and storage of retinyl-15-14C palmitate-9,10-3H in the rat. Retinyl-15-(14)C palmitate-9,10-(3)H was fed to rats in order to study hydrolysis and reesterification of this ester during digestion, absorption, transportation, and storage. After administration there was a progressive increase in the (14)C/(3)H ratio of the retinyl esters as they moved from intestinal contents to intestinal mucosa, lymph, and liver, which indicates that repeated hydrolysis and reesterification occur during the digestion and assimilation of this ester.


Heterologous and homologous inseminations with human semen frozen and stored in a liquid-nitrogen refrigerator.


Lipid monolayers: action of phospholipase A of Crotalus atrox and Naja naja venoms on phosphatidyl choline and phosphatidal choline. The activity of phospholipase A on phosphatidyl choline and phosphatidal choline spread as monolayers on phosphate buffers containing snake venom (Crotalus atrox or Naja naja) was studied by measuring the fall of surface potential as a function of time, pH, film pressure, temperature, and concentrations of phosphate and venom. At 25 degrees C, pH 7.0, and 0.2 micrograms of venom per ml, optimal activity was observed with both venoms on both substrates at 12 dynes/cm film pressure on 0.04 m phosphate. Under these conditions, the pH optimum for C. atrox was broad (6.6-7.4) and that for N. naja was sharp (8.0) for the action on phosphatidyl choline, whereas both venoms had a sharp optimum at pH 8.0 in their action on phosphatidal choline. The optimal temperature with phosphatidyl choline was 27.5 degrees C for N. naja and 40 degrees C for C. atrox. In line with studies of phospholipase A activity in bulk phase in ether, phosphatidal choline was attacked much more slowly than phosphatidyl choline by C. atrox. Under conditions where both venoms had equal activity on phosphatidyl choline, C. atrox was only half as active as N. naja on phosphatidal choline. The studies suggest that the linkage of the hydrophobic chains in glycerophosphatides may affect their interaction with proteins.


Two-column gas-liquid chromatography of fatty acid methyl esters. Fatty acid methyl esters were separated into fractions according to chain length on a nonpolar gas-liquid chromatographic column. These fractions were collected and rechromatographed on a polar column. Temperature programming was used in both cases. Data are given for the accuracy of the double procedure applied to a synthetic mixture.


Use of constant composition polyvinylpyrrolidone columns to study the interaction of fat particles with plasma. Fat particles (lipoproteins of S(f) > 400) have been obtained from dog and human lymph and from human post-alimentary plasma. They were flocculated by a solution of 5% polyvinylpyrrolidone (PVP) in 10% NaCl and layered at the bottom of tubes of PVP of various concentrations between 2% and 5% (w/v). As the concentration of PVP increased, a greater proportion of the particles accumulated at the top of the tube ("primary" particles). When the concentration of PVP in the tube was held constant at 3% PVP, dilution of the sample with plasma was found to produce an increased proportion of bottom particles ("secondary" particles). This observation suggests that bottom particles result from an interaction of top particles with plasma.


Partial purification of monoglyceride lipase from adipose tissue. A monoglyceride lipase was partly purified from extracts of rat adipose tissue by ammonium sulfate fractionation, alcohol precipitation, and lyophilization, or by ammonium sulfate fractionation, sodium deoxycholate treatment, and a second ammonium sulfate fractionation. Partial purification and heat denaturation showed the lipase to be different from tributyrinase and from an enzyme(s) which hydrolyzes diglycerides and triglycerides. Although the best preparations hydrolyzed monobutyrin this activity decreased with purification, indicating that the enzyme acts on insoluble substrates and is therefore a lipase and not an esterase. Further-more, classification of the enzyme as a lipase is consistent also with its behavior with inhibitors, since low concentrations of esterase inhibitors, e.g., fluoride, sodium deoxycholate, and physostigmine did not inhibit lipolytic activity. Inhibition studies with EDTA, sodium pyrophosphate, protamine, and fluoride showed that the enzyme differs from clearing factor lipase. The enzyme catalyzed hydrolysis of monostearin in the pH range 6.3-9.0, with a maximum at 7.4-7.6.


Fat digestion and absorption in the adrenalectomized rat. Malabsorption of fat in the adrenalectomized rat has been confirmed. The criteria for adrenal hypofunction were more rigorous than in previous studies. The malabsorption is not due to impaired intestinal lipolysis or inadequate intestinal intracellular glyceride synthesis. Delayed gastric emptying is probably secondary to the malabsorption rather than a cause. It is postulated that impaired intestinal fatty acid activation may be the key defect and that in some way this inhibits fatty acid transport across the mucosal membrane.


Metabolism of hepatic and plasma triglycerides in rabbits given ethanol or ethionine. The formation and transport of hepatic triglyceride fatty acids (TGFA) were studied after intravenous administration of palmitate-1-(14)C or palmitate-9,10-(3)H in rabbits pretreated with ethanol or ethionine. Administration of ethanol produced significant hypertriglyceridemia without consistent accumulation of hepatic fat. The isotopic studies suggest that plasma free fatty acids were the major precursors of TGFA in d < 1.006 lipoproteins and that fatty acids synthesized in the liver were not the source of the hypertriglyceridemia in the ethanol-treated animals. Administration of ethionine resulted in an increased concentration of TGFA in the liver, a decreased level of TGFA in d < 1.006 lipoproteins and a very low specific activity in this plasma fraction. These findings suggest that the development of fatty liver after administration of ethionine is in part accompanied by impaired release of TGFA from the liver.


Complete separation of lipid classes on a single thin-layer plate. A double-development procedure employing first a polar and then a nonpolar solvent system is described for the complete separation by thin-layer chromatography of the main lipid classes encountered in natural lipids. For better quantification, long plates (34 cm) are employed. Diglycerides were separated from cholesterol, 1,2- from 1,3-diglycerides, and monoglycerides from phospholipids.


RNA biosynthesis in adipose tissue: effect of fasting. RNA metabolism has been examined in intact adipose tissue and isolated fat cells from rats. The lipocyte contains three species of RNA with sedimentation rates corresponding to those of ribosomal and transfer RNA. The de novo biosynthesis of RNA by adipose tissue cells in vitro was demonstrated. The base ratios of the RNA formed indicate that it was synthesized from a DNA template. Actinomycin D administered in vivo and in vitro decreased total RNA synthesis with the most marked effect on the synthesis of the heavy RNA components. Actinomycin D or puromycin added in vitro was not toxic: they did not inhibit total fatty acid biosynthesis or glucose utilization by the fat pad nor did they inhibit the immediate stimulation of fatty acid biosynthesis and glucose uptake by the addition of insulin in vitro. Starvation for 48-72 hr significantly depressed the synthesis of the heavy RNA components as measured by in vitro uridine incorporation into the individual RNA classes. Refeeding the fasted rat with glucose repaired the defect in RNA biosynthesis before the biosynthesis of monoenoic fatty acid was completely restored. Actinomycin D administered at the time of refeeding prevented the repair of monoenoic fatty acid synthesis. It is concluded that RNA metabolism is intimately involved in the control of biosynthetic reactions in adipose tissue.


Pneumohysterosalpingography in infertility and related gynecologic conditions: the Foley catheter technic.


Additional sterility factors in endometriosis.


The natural history of Klinefelter's syndrome.


A mission and an image.

A mission and an image.


Oral contraceptive program synchronized with moon phase.


Device for applying samples as a narrow band to thin-layer chromatograms. An applicator for the rapid transfer of samples in the form of a narrow band to thin-layer chromatograms is described. The entire sample, dissolved in a small volume of solvent, can be applied in 30 sec to a band 18 cm long.


Technics and complications of elective vasectomy. The role of spermatic granuloma in spontaneous recanalization.


Clinical study of quinestrol in infertile women.


Studies on the isoimmunization of mice with spermatozoa.


Quinestrol therapy in functional infertility.


Effect of prednisolone upon normal and pathologic human spermatogenesis.


Laminectomy for the removal of spinal cord tumors.


Effects of mechanical stresses on the spinal cord in cervical spondylosis. A study on fresh cadaver material.


Steroidogenesis in mammalian gonads as related to fertility and infertility.


Aneurysms of the anterior communicating artery and gross anomalies of the circle of Willis.


Cervical spondylotic myelopathy.

Cervical spondylotic myelopathy.


Methyl methacrylate investment of intracranial aneurysms. A report of seven years experience.


Beta-glucuronidase during menstruation.

Beta-glucuronidase during menstruation.


Massive plexiform neurofibroma of the occipital scalp. Case report.


Extracalvarial meningioma. Case report.

Extracalvarial meningioma. Case report.


Angiographic demonstration of blood supply to the tentorium. Case report and review of the literature.


Extradural spinal sensory rhizotomy.

Extradural spinal sensory rhizotomy.


Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage. IV. Cerebral angiography. An analysis of the diagnostic value and complications of carotid and vertebral angiography in 5,484 patients.


Substrate interaction during shock loadings to biological treatment processes.


Acute and long-term effects of organic insecticides on two species of stonefly naiads.


Feasibility of biological treatment of potato processing wastes.


Performance of single family septic tank systems in Alaska.


Prediction of pollutionfrom planned wastewater outfalls.


Stream surveillance programs.

Stream surveillance programs.


Treatment of parathion wastes and other organics.


Application of the chlorate BOD procedure to routine measurement of wastewater strength.


Subresidual chlorination.

Subresidual chlorination.


Secretion and absorption of mesobilirubinogen-H3 studied by autoradiography.


Effects of dextran on blood pressure, saline consumption, and organ structure of control and deoxycorticosterone acetate-treated rats.


The course and reversibility of the calcium effect on the ultrastructure of the rat parathyroid gland in organ culture.


Cellular reactions to methylcholanthrene-induced sarcomas transplanted to isogenic mice.


Electron microscopic studies of acute tubular necrosis. Early changes in proximal convoluted tubules of the rat kidney following subcutaneous injection of glycerin.


Inhibition and augmentation of pancreatic elastase by serum fractions from pregnant and normal humans.


Enteromegaly and steatorrhea in the rat following intraperitoneal quinacrine (atrabrine).


The Jezail bullet.

The Jezail bullet.


223. Aminocaproic acid and other inhibitors of fibrinolysis.


The doctor-patient relationship. VII. Family bonds.


Detachment of the retina.

Detachment of the retina.


Amblyopia.

Amblyopia.


Disorders of vision in children.

Disorders of vision in children.


The current status of orthoptics.

The current status of orthoptics.


Diseases of the eyelids.

Diseases of the eyelids.


An assessment of antimalarials in the treatment of the connective tissue diseases.


Cataract.

Cataract.


An approach to the problem of chest injuries.


The clinical features and diagnosis of parotid calculi.


Lead absorption and the health of a community.


Stress fractures.

Stress fractures.


Anaphylactoid shock induced by oral ampicillin in a woman with Addison's disease.


Lincomycin hydrochloride in general practice.


Report on a maternity unit. The first thousand confinements.


A new corticosteroid-antibiotic preparation in eye and ear infections.


Insuring life the right way.

Insuring life the right way.


The electrical coupling of sodium and potassium movements across muscle fire membrane.


Precision technique for measuring asymmetric distortions in optical lenses.


Anticoincidence shielded gamma-ray spectrometer for nuclear reaction studies.


The diversion of arterial blood flow to growing bone.


Combined testicular and foot lymphangiography in testicular carcinomas.


Sympathectomy versus arterial operations.


Reform in surgical education.

Reform in surgical education.


The prevention of radio-osteomyelitis in the mandible and maxilla.


A new common duct dilator and stone basket.


Intracavitary balloon pressure dressing.


Tracheobronchial cytology after laryngectomy for carcinoma.


Peripheral arterial embolism.

Peripheral arterial embolism.


Total red cell and plasma volume alterations occurring with extensive surgery in humans.


Hypokalemia associated with sigmoid volvulus.


Mast cells and cancer of the cervix.

Mast cells and cancer of the cervix.


An evaluation of postoperative respiratory maneuvers.


Replacement of the canine mitral valve with a graphite coated hinged-leaflet valve.


The effect of adrenalin on the blood flow to a long bone.


The distribution of ventilation following operations.


Cerebral blood flow following severe hemorrhage.


The results of surgical treatment of cancer of the stomach.


The surgical treatment of multisegmental and localized bronchiectasis.


A safe technique for resection of the nonobstructed superior vena cava.


The contribution of the inferior thyroid artery to the blood supply of the human trachea.


Tissue typing. Introduction.

Tissue typing. Introduction.


A berrant right subclavian artery. Clinical and roentgenologic aspects.


Contact-induced cytotoxicity and its relation to cellular immunity.


The linkage between teichoic acid and glycosaminopeptide in the walls of a strain of Staphylococcus lactis.


Blastogenesis in vitro and histocompatibility.


The specific requirement for sodium chloride for the active uptake of L-glutamate by Halobacterium salinarium. 1. Uptake of l-glutamate by Halobacterium salinarium is dependent on high concentrations of sodium chloride in the environment. When the sodium chloride is replaced by isomolar concentrations of potassium chloride, sodium acetate or potassium acetate, only negligible uptake occurs. 2. Most of the glutamate taken up can be shown to be in the cells in the free state and at a concentration of at least 50 times that in the medium. Sodium chloride is therefore required for an active transport of the glutamate into the cells. 3. The question whether sodium chloride is essential for the actual migration of glutamate across the cell envelope or for the mechanism supplying energy for this migration is discussed on the basis of experiments on endogenous respiration and with inhibitors.


The production of lymphocytotoxic antisera of narrowed specificity by selective adsorption and immunization.


Allo-antigens and antigenic factors of human leukocytes. A hypothesis.


Amino acid incorporation by preparations from the developing rat brain. 1. A study has been made of the ability of cerebral microsome-cell sap systems, taken from rats at various ages, to incorporate [(14)C]valine. 2. The systems appear to follow Michaelis-Menten kinetics when cell sap is considered as substrate, microsomes as enzyme and total counts/mg. of microsomal protein as a measure of reaction velocity. 3. Reproducible ;affinity constant' values are obtained, and the system from 4-day-old rats has a higher V(max.) and affinity constant than the system from adult rats. 4. It is suggested the the amino acid-incorporating ability of different systems may be compared by this means.


Detection and determination of adenosine diphosphate and related substances in plasma. 1. A method is described for detecting and determining the products of metabolism of ADP added to plasma at initial concentrations of about 1mum-ADP. 2. ATP, ADP, AMP, adenosine, inosine and hypoxanthine were detected in human platelet-rich plasma after incubation with ADP and in the presence of either heparin or heparin-citrate. 3. The products of incubation of ADP with human platelet-poor plasma in the presence of heparin were the same as with platelet-rich plasma, except that, when the initial concentration of ADP was 1.5mum, little or no ATP was detected. 4. The ATP detected in platelet-rich plasma when 1.5mum-ADP was initially incubated was present in the platelets and not in the plasma. 5. The time for 50% decay of ADP in either platelet-rich or platelet-poor plasma in the presence of heparin was about 20min. when the initial concentration of ADP was 200mum, but was 6-9min. when the initial ADP concentration was 1.5-2.5mum. The corresponding values in the presence of heparin-citrate were about 45min. and about 9-12min. respectively. 6. Hypoxanthine accumulated to a greater extent in platelet-rich than in platelet-poor plasma after the addition of ADP. 7. After incubation for 15-20min. of either platelet-rich plasma or suspensions of washed platelets in saline with adenosine at an initial concentration of about 3-4mum, ATP, ADP and AMP were detected in the platelets. Similar incubations of washed platelets with inosine also showed the formation of these substances, but to a much less extent. 8. After the addition of adenosine to suspensions of washed platelets in saline, inosine and hypoxanthine were detected in the incubation mixture. After the addition of inosine, hypoxanthine was detected. 9. When ADP at an initial concentration of 1.5mum was added to platelet-rich plasma containing adenosine deaminase, no adenosine was detected in the incubation mixture. There was no difference in the rate of decay of ADP in the presence or absence of the deaminase, but ATP formation was decreased in its presence.


Tissue typing. Comments on the Workshop results.


Absorption, storage and distribution of 3-dehydrovitamin A in the rat. 1. The metabolism of 3-dehydroretinal was found to be similar to that of retinal. It alleviated all the symptoms of vitamin A deficiency, and promoted the growth of vitamin A-deficient rats. 2. When administered orally, 3-dehydroretinal was reduced in the intestine of the rat and subsequently esterified and transported to the liver, where it was stored mainly as the higher fatty acid ester. 3. Intraperitoneal administration of the compound led to the accumulation of 3-dehydrovitamin A in liver and other tissues. Subcutaneous administration of the compound showed a good growth response in the rat. 4. The ratio of 3-dehydroretinyl higher fatty acid ester to 3-dehydroretinol in liver, in the post-absorptive state, was nearly 93:7. 5. There was a linear relationship between the 3-dehydroretinol concentrations of blood and liver of rats. 6. Administration of 3-dehydroretinal at a dosage of 7.5mg./day for 3 days brought about hypervitaminosis A in the rat. 7. The maximal retention of 3-dehydrovitamin A by the kidneys was at an optimum dosage of 4.5mg./day for 3 days.


Intracellular localization of mevalonate-activating enzymes in plant cells. Mevalonate-activating enzymes are shown to be present in the chloroplasts of French-bean leaves. The chloroplast membrane is impermeable to mevalonic acid. Mevalonate-activating enzymes also appear to be found outside the chloroplast. These results support the view that terpenoid biosynthesis in the plant cell is controlled by a combination of enzyme segregation and specific membrane permeability.


The synthesis of polyribonucleotides by cytoplasmic enzymes. 1. The possibility that the cell cytoplasm contains enzymes catalysing the biosynthesis of RNA was investigated in fractions obtained by differential centrifugation of homogenates of Landschutz ascites-tumour cells. 2. The microsomal fraction was shown to be most active in incorporating UMP residues from [alpha-(32)P]UTP into polyribonucleotide material. 3. The same fraction also incorporated [(3)H]CTP, [(3)H]ATP and [(3)H]GTP separately and independently of the presence of complementary ribonucleoside 5'-triphosphates. 4. The reaction was promoted by the addition of RNA and showed an absolute requirement for Mg(2+) ions. 5. Analysis of alkaline hydrolysates of the reaction products after the incorporation of [alpha-(32)P]UTP showed that most of the radioactivity was recovered in (2',3')-UMP residues irrespective of whether CTP, ATP and GTP were present in the reaction mixture. 6. Extraction of RNA from the reaction mixtures after the incorporation of [(3)H]ATP, [(3)H]GTP or [(3)H]CTP and analysis by sucrosedensity-gradient centrifugation showed no labelling of the ribosomal RNA. Radioactive material appeared between the 4s region and the meniscus of the sucrose gradient. In agreement with this observation, determinations of the chain length of the product showed that only short sequences of polynucleotides were synthesized. It is concluded that only homopolyribonucleotide synthesis is catalysed by the microsomal fractions and that there is little or no synthesis of RNA-like heteropolymers.


The oxidation of Schiff bases of pyridoxal and pyridoxal phosphate with amino acids by manganous ions and peroxidase. 1. Oxygen was taken up rapidly when pyridoxal or pyridoxal phosphate was added to mixtures of pea-seedling extracts and Mn(2+) ions. 2. The increases in total oxygen uptake were proportional to the pyridoxal or pyridoxal phosphate added and were accompanied by the disappearance of these compounds. 3. In addition to Mn(2+) ions, the reactions depended on two factors in the extracts, a thermolabile one in the non-diffusible material and a thermostable one in the diffusate; these factors could be replaced in the reactions by horse-radish peroxidase (donor-hydrogen peroxide oxidoreductase, EC 1.11.1.7) and amino acids respectively. 4. When pyridoxal phosphate was added to mixtures of amino acids and Mn(2+) ions oxygen uptake was rapid after a lag period of 30-90min.; the lag period was shortened to a few minutes by peroxidase, particularly in the presence of traces of p-cresol, or by light. 5. When pyridoxal replaced pyridoxal phosphate relatively high concentrations were required and peroxidase had only a small activating effect. 6. Pyridoxal or pyridoxal phosphate disappeared during the reactions and carbon dioxide and ammonia were formed. 7. With phenylalanine as the amino acid present, benzaldehyde was identified as a reaction product. 8. It is suggested that the reactions are oxidations of the Schiff bases formed between pyridoxal or pyridoxal phosphate and amino acids, mediated by a manganese oxidation-reduction cycle, and resulting in oxidative decarboxylation and deamination of the amino acids.


A comparison of aminoacyl-beta-naphthylamide hydrolases in extracts of human tissues. 1. The aminoacyl-beta-naphthylamide-hydrolase activities of extracts of human liver, kidney, pancreas and small intestine were partially purified by chromatography on DEAE-Sephadex. 2. The enzymes from the different tissues showed slight variations in chromatographic behaviour and in mobility on starch-gel electrophoresis. 3. Michaelis constants for the hydrolysis of l-leucyl- and l-alanyl-beta-naphthylamide by the partially purified enzyme fractions were determined by a spectrofluorimetric assay method. The enzymes from different sources gave similar K(m) values. 4. l-Leucinamide and l-leucylglycine were competitive inhibitors of the hydrolysis of both substrates. Values of K(i) (leucinamide) and K(i) (leucylglycine) respectively were constant whatever combination of enzyme and substrate was used. 5. The relevance of these results to the identity or non-identity of the enzymes from different tissues is discussed.


Hybridization in vitro between wild-type and mutant forms of glutamate dehydrogenase from Neurospora crassa.


The incidence and severity of muscle pains after suxamethonium when preceded by gallamine.


Tissue typing by means of mixed agglutination.


The isolation and testing of cytolytic factor.


Report on the Workshop on Histocompatibility Testing, held in Leiden, August 1965.


How will the hospital dietitian function in the future?


Brownies: comparison of various market forms.


The collection of boiler condensate for the production of pure water.


Hormonal control of the glycerol-1-phosphate system by thyroid hormones. Experiments with isolated perfused rat livers.


Distribution of DF32P in mouse organs. I. The effect of route of administration of incorporation and toxicity.


Subungual exostosis.

Subungual exostosis.


Thyroid cancer after 131-I therapy for thyrotoxicosis.


A severe complication of smallpox vaccination.


Three new insulin preparations.

Three new insulin preparations.


Peritrate is no longer claimed to aid survival.


The effect of non-personality factors on ink-blot responses in a cross cultural study.


Healthy, neutral, and unhealthy content in the Rorschach reponses of schizophrenic and normal adults.


Why I originated the inbred strains of mice.


Correlation of behavior and catecholamine metabolite excretion.


The clinical physician as a research instrument: In defense of clinical judgment as a scientific measure.


Emotional illness in habitual aborters following suturing of the incompetent cervical os.


A technique for assaying the kinetics of norepinephrine metabolism in the central nervous system in vivo.


A clinical refresher program for a non-practicing therapist.


Sex differences in autonomic responses during instrumental conditioning.


Alterations in O2 uptake following hemorrhage in dogs.


Risk of mortality in interrupted exposure to 100 percent O-2: role of air vs. lowered Po2.


Effect hypoxia on oxygen transport in sheep with different hemoglobin types.


Social-situational barriers to patient response in occupational therapy.


Pulmonary hemodynamics during acute acid-base changes in the intact dog.


Muscle proteins and DNA in rat quadriceps during growth.


Metabolism of cu-64-labeled copper by the isolated rat liver.


Public relations for occupational therapists.


Lipid metabolism of diaphragm in normal and nephrotic rats.


The occupational therapist in rehabilitation: projections toward the future.


Occupational therapy in community mental health.


Effect of fasting and feeding on lipid metabolism of pigeon pancreas.


Effect of denervation and muscular dystrophy on amino acid transport in skeletal muscle.


Metabolism of labeled pyridoxine in the rat.


Local and systemic effects of ionizing radiation on bone growth.


A functional stool, adapted to provide independence for a severely disabled arthritic with fused spine and marked limitation of hip flexion.


A frame for supporting the cerebral palsied child.


Comparison of glucose uptake and carbohydrate utilization in red and white muscle.


Glycogen metabolism in red and white muscle.


Effect of light on corticosterone levels in plasma of rats.


Competition for transport between methyldopa and other amino acids in rat gut loops.


Rat bile tree during reflux perfusion.

Rat bile tree during reflux perfusion.


Intestinal bile salt transport: structure-activity relationships and other properties.


Role of bile ducts during secretin choleresis in dogs.


Effect of alkalinization on peritoneal diffusion of uric acid.


Eelectrical stimulation of the isolated cat iris.


Frequency stabilization in the motor centers of spinal cord and caudal brain stem.


Signal-handling characteristics of load-moving skeletal muscle.


Impedance changes in the lateral geniculate of cat.


Distribution of leukocytes in blood flowing through arteries.


Liver blood flow measured by portal venous and hepatic arterial routes with Kr-85.


Effect of posture on formation and evacuation of lymph.


Femoral arterial circulation in nonhypoxic dogs at reduced barometric pressures.


Blood pressure and heart weight in immature and spawning Pacific salmon.


Micropuncture study of urea transport in rat renal medulla.


Tubular salt and water transport in hydrated dogs studied with push-flow technique.


Action of ouabain on sodium transport in the toad urinary bladder.


Ionic mechanisms for sodium and chloride transport across turtle bladders.


Acidification of mucosal fluid by transport of bicarbonate ion in turtle bladders.


Rapid automated determination of biphenyl in citrus fruit rind.


Determination of cyclamate in soft drinks by gas chromatography.


The determination of cyclamate in soft drinks by titration with sodium nitrate.


Nitrogen factor for kidney.

Nitrogen factor for kidney.


The paper chromatography of some purines, pyrimidines and imidazoles.


Nomogram for the rapid calculation of cardiac output at the bedside.


Probit analysis of burn mortality in 1,831 patients: comparison with other large series.


Response to gastrointestinal pacing: antral, duodenal and jejunal motility in control and postoperative patients.


Development of superficial carcinoma of the stomach. Report of late recurrence.


Barium granuloma within the peritoneal cavity: ureteral obstruction 7 years after barium enema and colonic perforation.


Mechanical small bowel obstruction due to acute appendicitis: review of 10 cases.


Successful resection of an idiopathic aneurysm of the superior mesenteric artery: case report and literature review.


Subclavian steal syndrome secondary to embolism. First reported case.


Some biochemical and biophysical aspects of joint stiffness: role of collagen synthesis as opposed to altered molecular bonding.


Coagulation changes in clinical shock. I. Effect of hemorrhagic shock on clotting time in humans.


Coagulation changes in clinical shock. II. Effect of septic shock on clotting times and fibrinogen in humans.


Effects of adrenergic blocking agents on renal blood flow in normovolemia and experimental hypovolemia.


Temporary use of ex-vivo heterologous liver for hepatic insufficiency: metabolic effects and sensitivity to perfused protein in dogs.


Relationship of histamine-stimulated gastric secretion to gastric blood flow and oxygen consumption: patterns of arterial and venous response.


Effect of portacaval shunt on gastric acid secretion in dogs with liver disease, portal hypertension and massive ascites.


Hypogammaglobulinemia in Hodgkin's disease treated with nitrogen mustard.


Pneumococcal endocarditis in the penicillin era.


Basophilic leukemia.

Basophilic leukemia.


The effects of allopurinol on serum and urinary uric acid.


Dr. John H. Watson and the subclavian steal.


Onset of manifestations of hepatic porphyria in relation to the influence of female sex hormones.


Pericardial effusion of "gold-paint" appearance following myocardial infarction.


Failure of dexamethasone suppression in adrenal hyperplasia.


Renal papillary necrosis with special reference to chronic alcoholism. A report of 20 cases.


Prevention of recurrences of myocardial infarction. Comments on a previous article.


Radiation-induced adrenal medullary tumors in the rat.


Histopathology of amino acid deficiencies.


Alteration in elastin and orientation of collagen in angiolathyrism.


Role of smooth muscle cells in healing of injured arteries.


Mesodermal changes in adenomatous polyps of the large intestine.


The renal tubule in experimental lead intoxication.


Bacterial endocarditis involving prosthetic mitral valves. Clinical and pathologic observations.


Changes in the conformation of chymopapain during the activation process.


The nature of poxvirus-induced deoxyribonucleas.


Free sugars in alloxan diabetic rat nerve.


Collagen synthesis by isolated bone cells.


[Hepatic cirrhosis and cyanosis. Considerations on a case].


The clinical picture of Hodgkin's disease.


The pathology and nomenclature of Hodgkin's disease.


Lymphangiography in Hodgkin's disease: indications and contraindications.


The staging of Hodgkin's disease.

The staging of Hodgkin's disease.


Graft-versus-host reaction in lymphoid proliferation.


Survey of viral oncology with particular reference to lymphomas.


Host-virus relationships in virus-induced tumors and transformed cells.


High incidence of Hodgkin's disease in children in Lebanon.


Relative increased incidence of childhood Hodgkin's disease in Peru.


The destructive effect of radiation on lymphatic tissue.


Evidence for a tumoricidal dose level in the radiotherapy of Hodgkin's disease.


Evidence for an orderly progression in the spread of Hodgkin's disease.


Prophylactic treatment of adjacent areas in Hodgkin's disease.


Long-term results of palliative and radical radiotherapy of Hodgkin's disease.


The surgical treatment of Hodgkin's disease.


Extended-field radical radiotherapy in advanced Hodgkin's disease: short-term results of 2 randomized clinical trials.


Current clinical trials in the radiotherapy of Hodgkin's disease at Institut Gustave Roussy.


Approaches to improving the chemotherapy of Hodgkin's disease.


Summary of infectious complications occurring in patients with Hodgkin's disease.


Chemotherapy as a primary treatment of Hodgkin's disease.


New chemotherapeutic agents in Hodgkin's disease.


Patterns of commissural responses in the cerebellar nuclei.


Membrane potential of cerebral cortical cells during reading depression and asyxia.


The separation of some alkyl selenium compounds by gas chromatography.


Multi-dimensional chromatography using different developing methods. IV. Rational identification of fatty acid esters by means of programmed distribution of fractions in two-dimensional (GC-TLC) chromatograms.


A complementary thin layer and gas-liquid chromatographic procedure for fatty acid analysis.


The cytogenetics of Lotus. XI. The use of thin-layer chromatography in the separation of secondary phenolic compounds in Lotus (Leguminosae).


Determination of 18 to 22 mole ethoxymers in nine mole ethylene oxide adduct of p-nonylphenol.


The thin-layer chromatography of 2,4-dinitrophenyl ethers of some hydroxy compounds.


Quantitative determination of griseofulvin and griseofulvin-4'-alcohol in plasma by fluorimetry on thin layer chromatograms.


The use of tert.-butyl chromate for the location of steroids on paper chromatograms.


Multiple spot phenomena of 2-PAM and metabolite on paper chromatograms.


Irreproducibility in the quantitative calibration of a flame ionisation detector.


Gas chromatography of hexosaminitols.

Gas chromatography of hexosaminitols.


A continuous chromatographic column.

A continuous chromatographic column.


Separation and identification of amino acids on starch thin layers.


A modified applicator for the uniform coating of thin-layer plates.


Separation of epithio and epoxy fatty ACIDS AND THEIR DERIVATIVES BY THIN-layer chromatography.


Chromatography on plaster of Paris.

Chromatography on plaster of Paris.


Spectrophotometric determination using anthrone for sugars separated by cellulose thin-layer chromatography.


Quantitative analysis of chlorophenothiazine by thin layer chromatography.


Separation of methionine and selenomethionine by thin-layer chromatography.


A device for application of samples to a paper chromatogram.


Paper chromatography in extra-long tanks.


Paper chromatographic separation and behavior of the cis- and trans-isomers of cinnamic acid derivatives.


Crash and survive.

Crash and survive.


Current thinking on antidepressants.

Current thinking on antidepressants.


The college death.

The college death.


Present status of uterine curette.

Present status of uterine curette.


Spontaneous regression of cancer and long term recrudescences.


Symptomatic coarctation of infancy.

Symptomatic coarctation of infancy.


The anatomy of the maternal side of the placenta.


The biological status of carcinoma in-situ of the uterine cervix.


Pelvic contraction in breech presentation.


Recurrence of defective folate metabolism in successive pregnancies.


Some aspects of placental carbohydrate metabolism in human diabetes.


Observations on the plastic intrauterine contraceptive device.


Blood loss at caesarean section.

Blood loss at caesarean section.


Growth of human cervical epithelium in millipore filter chambers in the rat.


Oral progestogens and adenocarcinoma of the uterus. An account of 3 cases of advanced endometrial carcinoma treated with an oral progestogen.


Isoxsuprine hydrochloride (Duvadilan) in pregnancy with incompetent cervix following amputation. A case report.


Abdominal pregnancy, with survival of the child, following genital tuberculosis.


Successful pregnancy in a patient with adrenogenital syndrome.


Multiple system collagen disease: a new approach to its diagnosis.


Early recognition of the coronary prone individual.


The chemotherapy of malignant disease.

The chemotherapy of malignant disease.


Books as clinical tools.

Books as clinical tools.


Sawtooth design gives glareproof view.

Sawtooth design gives glareproof view.


As the costs accelerate, so must the controls.


Modernization revitalized this hospital.


Profit sharing can help nonprofit hospitals.


Methods study shaped team nursing plan.

Methods study shaped team nursing plan.


Better systems improved care, cut costs.


A planned-time program can boost nursing morale, provide balanced coverage.


Be sure employes know your story if you want effective cooperation.


Seven-day schedule breaks weekend jam.

Seven-day schedule breaks weekend jam.


Some idiosyncrasies of doctors cost hospital time and money.


False economy may be why you have high O.R. expenses.


Nurses' salaries are not the only cause of increasing hospital costs.


Careful purchasing, good personnel management cut costs for pharmacy.


Invention and innovation cut expenses at Sinai Hospital.


C.A.S.H. provides new dietary controls.

C.A.S.H. provides new dietary controls.


Queuing theory ends long, hungry wait.

Queuing theory ends long, hungry wait.


Pre-trained hands cut breaking-in costs.


Competitive bids are only the beginning.


Personal property may not be tax exempt.


Tape recorder collects work study data.

Tape recorder collects work study data.


A new title on the administrative team.

A new title on the administrative team.


Group gets best instead of cheapest buy.


Visual and auditory stores in short-term memory.


Learning and retention of word-pairs with varying degrees of association.


Remembering a list of two-digit numbers.


The effect of interpolated activity on a treble right-left alternation task.


Extinction of a running response as a function of reinforcement magnitude.


The effect of superseding signals.

The effect of superseding signals.


Disruption of a position-reversal learning set in the rat.


Spontaneous speech generation.

Spontaneous speech generation.


Decisions concerning the rejected channel.


The role of the interpolated task in short-term retention.


On determining pain thresholds using the limiting method.


Payoff: a neglected factor in reaction time measurement.


An E.C.G. galvanometer used as a shutter.


Inheritance of acquired diabetes?

Inheritance of acquired diabetes?


Rapid faecal transmission and invasive amoebiasis in Durban.


Exchange transfusion mortality in a community hospital.


Relationship between toxic erythema and infant maturity.


Studies in cystathioninemia.

Studies in cystathioninemia.


Patients, psychiatric problems, and nonpsychiatric physicians in a prepaid group practice medical program.


Empathic relationship therapy utilizing student nurses: a five-year pilot study.


More on depression and dreams.

More on depression and dreams.


Differential effects of abrupt versus gradual withdrawal of chlorpromazine in hospitalized chronic schizophrenic patients.


Interaction of deoxyribonucleic acid with poly-4-vinylpyridine.


Chloramphenicol inhibition of the formation of particulate mitochondrial enzymes of Saccharomyces cerevisiae.


The lucites and sunscreening preparations.


Treatment of giant hydronephrosis.

Treatment of giant hydronephrosis.


The uptake of C14 5-hydroxytryptamine creatinine sulphate and C14 5-methyl-methionine by the epiphysis of Xenopus laevis Daudin.


"Time present and time past are both perhaps present in time future".


Further observations on calcified medullary bone lesions in chronic pancreatitis.


Superior mesenteric arteriovenous fistula following small bowel resection.


Treatment of achalasia of the cardia.

Treatment of achalasia of the cardia.


Does the pancreatic gland regenerate?

Does the pancreatic gland regenerate?


Histamine and gastric secretion.

Histamine and gastric secretion.


Cytostatic treatment of polycythaemia vera with a methylbenzylhydrazine derivative.


Overtime exemption for hospitals.

Overtime exemption for hospitals.


Radiography of animal tissue.

Radiography of animal tissue.


To die as a man: disease, truth, and Christian ethics.


Thermoluminescence of unirradiated MgO and Mg(OH)2.


Diagnosis and treatment of respiratory acidosis.


Postoperative evaluation of the surgical patient.


Crash diets and wrestling.

Crash diets and wrestling.


University of Iowa College of Medicine Clinical pathological conference no. 456.


Use a corporate trustee to manage your estate.


Hepatic vein thrombosis.

Hepatic vein thrombosis.


Incorporation of dietary elaidic acid in tissues and effects on fatty acid distribution.


Tissue and intracellular distribution of radioactive thiamine in normal and thiamine-deficient rats.


Effects of twelve common fatty acids in the diet upon the composition of liver lipid in the rat.


In vivo intestinal absorption of L-alanine in irradiated rabbits.


Post-ruminal degradation and absorption of carbohydrate by the mature ruminant.


Effect of vitamin E, arginine and methionine on free amino acids and lipids in selected rat tissues.


Gastric function and intestinal absorption after gastric freezing in the rat.


Function changes secondary to local irradiation in kidneys damaged by ischemia.


Urological findings in 58 surgically verified cases of parathyroid adenoma.


Individual renal plasma flow determination without ureteral catheterization.


Value of renal angiography in everyday urologic practice.


Cold sterilization of ureteral catheters with ethylene oxide gas.


The results of treatment of ureteral reflux by revision of the bladder neck or urinary diversion.


Emphysematous pyelonephritis.

Emphysematous pyelonephritis.


Recurrent varicose veins.

Recurrent varicose veins.


Acute epididymo-orchitis: with special reference to its differential diagnosis from torsion of the testis.


Q fever, brucellosis and leptospirosis among abattoir workers in New South Wales.


Dialysis: a comparison of the efficiency of peritoneal dialysis with the artificial kidney.


Proposed embryopathic relation between mumps virus and primary endocardial fibroelastosis.


Copper intoxication. Report of a case with observations on ceruloplasmin.


Effect of live measles vaccine on the platelet count.


Women in medicine. An international study.


Extrarespiratory streptococcal infections. Importance of the various serologic groups.


Acid-base balance--a pattern-analysis diagram.


Case records of the Massachusetts General Hospital. Case 36-1966.


A case of copper poisoning.

A case of copper poisoning.


Direct billing versus assignment.

Direct billing versus assignment.


Mumps and the endocardium.

Mumps and the endocardium.


Time, motion, and pediatric practice.

Time, motion, and pediatric practice.


Heparin therapy of purpura fulminans.

Heparin therapy of purpura fulminans.


The nature of a small pediatric group practice. 1.


Relationship between erythrocyte glucose-6-phosphate dehydrogenase and the hemolytic anemia of infection.


Foreign body of the palate. A case report.


Further studies on the incubation of tyrosine-UL-C14 with beef thyroid tissue slices.


Cardiovascular response to changes in arterial carbon dioxide tension. An experimental study on thoractomized dogs.


Considerations on the efficiency of the aeration process.


The determination of cyanide in low concentration.


The oxygen demand number, a new tool in the estimation of oxygen demand of industrial and domestic waste water.


Preservation of water samples for inorganic nitrogen analyses with mercuric chloride.


Ultrastructure of rabbit synovial membrane.


Hyperuricaemia in polycythaemia vera.

Hyperuricaemia in polycythaemia vera.


Treatment of gout by reduction of uric acid production.


Protective effect of traumatic lesions on rheumatoid arthritis.


Idiopathic retroperitoneal fibrosis associated with an arteritis.


Eye injuries: emergency treatment.

Eye injuries: emergency treatment.


Steroid cataract.

Steroid cataract.


Chest injuries.

Chest injuries.


Angle-closure, pupil dilatation, and pupil block.


Exploratory craniotomy in compressive visual failure.


Anterior lenticonus and Alport's syndrome.


Typical ophthalmoscopic picture of "cherry-red spot" in an adult with the myoclonic syndrome.


Amyloid tumours of the orbit.

Amyloid tumours of the orbit.


Unilateral vitiligo iridis.

Unilateral vitiligo iridis.


Haemangioma of the iris.

Haemangioma of the iris.


Liposarcoma with orbital metastases. Case report.


Clinical electro-oculography.

Clinical electro-oculography.


Benign gonococcal sepsis with skin lesions.


Studies in syphilis epidemiology.

Studies in syphilis epidemiology.


Intramuscular injection of procaine penicillin combined with oral administration of chloramphenicol in the treatment of gonorrhoea.


Assessment of the "luotest" in late syphillis.


Dynamic changes in serum transaminases in patients with syphilis.


Chronic intermittent priapism.

Chronic intermittent priapism.


Thrombophlebitis in Reiter's syndrome.

Thrombophlebitis in Reiter's syndrome.


TRIC agent; characteristics and detection by laboratory methods.


Cholinergic and monoaminergic pathways in the hypothalamus.


Simultaneous vaccination of cattle against rinderpest and contagious bovine pleuropneumonia.


Results of subcutaneous inoculation of filamentous and non-filamentous forms of Mycoplasma mycoides into cattle.


The use of hypnosis in the treatment of exhibitionism. The use of hypnosis in the treatment of exhibitionism is described in three patients in whom the condition had been present for more than five years. In each patient there was no subsequent recurrence of the exhibitionism once therapeutic suggestions had been made in a deep hypnotic trance, the follow-up period being respectively five years, four and a half years, and one year.The method of treatment and the results are discussed in terms of the concepts of behaviour therapy.It is concluded that with certain patients suffering from exhibitionism the use of hypnosis may well be one of the best methods of treatment, but considerable care should be exercised to exclude those patients with an underlying psychosis, mental defect or psychopathic condition. It is also noted that the efficacy of the treatment would appear to depend on achieving a satisfactory depth of hypnotic trance. If this is not reached, the results are less likely to be successful.


Pseudocyst of the adrenal gland.

Pseudocyst of the adrenal gland.


Circulating cancer cells.

Circulating cancer cells.


The plasma phenolsulfonphthalein index (PSPI) of renal function. II. Correlation with other parameters of renal function and indications for use. The plasma phenolsulfonphthalein index (PSPI) was determined in 175 subjects and was compared with levels of blood urea nitrogen (BUN) and serum creatinine, 15-minute urinary excretion of PSP, and clearance of creatinine, PAH and inulin. Statistical analyses indicate that the PSPI measures the same function as the 15-minute urine test when PSP is administered in a dosage of 1 mg./kg. body weight; and that, although the index cannot be used as a precise substitute for PAH clearance, it is equally repeatable and no greater error is associated with its measurement. The PSPI has been found of most value when complete, accurately timed urine collections are unobtainable because of urological abnormality or inability of the patient to co-operate.


Cigarette smoking and platelet aggregation. The influence of cigarette smoking on platelet aggregation was studied in habitual and non-habitual smokers. The results indicate that habitual smokers have a greater tendency to platelet aggregation than do non-habitual smokers. Acute effects of cigarette smoking were, however, not significant. The nucleotide content and the serotonin content of the platelets were analyzed. The adenosine nucleotide and serotonin contents were similar in smokers and non-smokers in the control state and neither showed significant changes on cigarette smoking. There were significant correlations between the control concentrations of the various nucleotides in both groups and there were even higher correlations after smoking. Platelet aggregation bore no demonstrable relationship to the nucleotide or serotonin contents of the platelet. We conclude that the long-term effect of smoking is probably more important than the acute effect.


Thiopental anesthesia and tannic acid diagnostic enemas. The administration to albino rats of tannic acid as a retention enema (in doses of 0.2 g./kg. body weight and over) prolonged the duration of anesthesia induced by thiopental given immediately before, or 72 hours after, the tannic acid. This dose of tannic acid corresponds, on the basis of body weight, to a radiodiagnostic enema of 2 1. of 0.25% tannic acid in barium sulfate suspension given to a child weighing 25 kg. By excluding certain hypothermic effects of tannic acid, it was concluded that thiopental potentiation was probably due to impairment by the tannic acid of the liver's ability to detoxify the barbiturate. The results suggest that a drug which is detoxified in the liver should be administered three to five days after a tannic acid-barium sulfate radiodiagnostic enema only with considerable caution.


The effect of intramuscular iron therapy on hematological values in normal men and women. It has been claimed repeatedly that iron stimulates hemoglobin formation in normal men and women. Because of the inconclusive evidence in the literature, the possible stimulatory action of iron on normal hemoglobin synthesis was reinvestigated by evaluating the effect of 1000 mg. of intramuscular iron on hematological parameters in six normal men and six normal women over a six-month period. Determinations of red cell and hemoglobin mass after three and six months and monthly determinations of hemoglobin concentration, packed cell volume, red cell count, reticulocyte count, mean corpuscular volume and mean corpuscular hemoglobin concentration showed no significant rise in either the men or the women. It is concluded that there is no demonstrable proof that the administration of iron stimulates erythropoiesis or hemoglobin synthesis in iron-sufficient normal men and women.


Characteristics of geriatric patients in mental hospitals in the Province of Quebec. The results of a questionnaire completed by the superintendents of five of the six major mental hospitals in the Province of Quebec concerning patients aged 60 and over showed that this group made up one-fifth to two-fifths of the total populations. The proportion of the population that was over age 60 when admitted varied from just under one-third to almost three-quarters. The ratio of those who died or were discharged at age 60 or more to the total elderly population varied greatly among institutions.Between 67% and 91% of the elderly were capable of ambulation and self-care with minimal help, and from 13.5% to 53% were considered mentally capable of living in a private home or residential home.Diagnostic types varied, among hospitals, from 28% to 65% functional, 13% to 32% organic and 4% to 33% senile psychoses.Experience with preventive and treatment programs elsewhere is discussed.


Right internal mammary artery implantation into right ventricular myocardium for revascularization of the entire heart: experimental data and preliminary report. The left internal mammary artery implant combined with epicardiectomy and free omental graft provides three extra-coronary sources of blood. This operation tested in dogs with 92% main-stem occlusion of three coronary arteries protected 75% of the animals. Applied clinically in over 100 patients, the operation resulted in 90% improvement. To obtain complete myocardial revascularization, the right internal mammary artery has been used as a fourth source of extra-coronary blood. In 57 animals, the right internal mammary arteries were implanted into the anterior walls of the right ventricle; in 80% this vessel formed anastomoses with the right coronary tree, and in 65% with the right and left coronary arteriolar systems. Six patients are described who underwent right internal mammary artery implantation; five of these in addition had the combined operation of left internal mammary artery implant, epicardiectomy and free omental graft. All patients had completely blocked right coronary arteries; in addition, five had advanced disease of the left coronary arterial tree.


The problem of routine circumcision.

The problem of routine circumcision. One hundred male infants were studied at the Kingston General Hospital, Kingston, Ontario, to determine the incidence and complications of routine circumcision. The parents were also interviewed concerning the reason for operation.In these 100 infants, complications, usually minor, were very common, and included hemorrhage (35), meatal ulcers (31), infection (eight), phimosis (one) and meatal stenosis.The reasons given for operation were prophylactic-to avoid the psychological trauma of later operations for infection, phimosis and "troubles" (40), cleanliness (11) and phimosis (four). The remaining cases were for social and other non-medical reasons. Attitudes of parents and physicians regarding circumcision varied from firm belief in its value to a casual approach. One-half of the babies had partial circumcisions, confirming previous suspicions that non-Jewish males frequently had partial operations. Partial operations do not always guarantee cleanliness and probably do not eliminate the risk of penile carcinoma in all cases, if smegma is carcinogenic. Routine circumcisions spare a few children psychologically traumatic operations at a later date and relieve parents of anxiety about the future of the uncircumcised child. This should be balanced against the complications which, although usually minor, may occasionally be serious.Between 1961 and 1962, at the Kingston General Hospital, 349 (48%) of 727 male newborn babies were routinely circumcised.


Fracture of the tibial malleolus treated by soft tissue repair.


Peritoneal dialysis. Indications and applications.


Plasma refractoriness in hemophilia.

Plasma refractoriness in hemophilia.


Insect sting reactions in children. Character, recognition, therapy.


The resurgence of natural child feeding. A study of 129 middle class mothers in a college community.


Dental needs of adolescents.

Dental needs of adolescents.


Homosexuality and the pediatrician. Early recognition and preventive counselling.


How behavior therapy affects schizophrenics. (An experimental approach).


Sudden and gradual onsets in schizophrenia.


Therapeutic effects of different modes of chlorpromazine administration.


Lithium salts in treatment of manic states.


Antidepressant treatment of depression in the recovering schizophrenic.


Thioridazine (mellaril) in the geriatric patient.


Syndrome of occlusion of rolandic veins.


The effects of physician's smoking on the treatment of smokers.


Clinical neuropathological conference.

Clinical neuropathological conference.


A super-suppressor on the thirteenth linkage group in Saccharomyces.


Genetical and embryological studies of the jt form of syndactylism in the mouse.


Compatibility and stability of diploids in Coprinus lagopus.


Large complex composite odontomas of the jaws.


A review of intestinal obstruction.

A review of intestinal obstruction.


Choledochoduodenostomy: an evaluation of its indications.


Operation of the gastrocamera in intragastric photography.


Arthrodesis of the tuberculous hip.

Arthrodesis of the tuberculous hip.


An angiographic study of neurocysticercosis.


Malignant solid teratoma of the ovary in children.


Segmental pulmonary alveolar agenesia of congenital origin.


A modification of an orthopedic bed.

A modification of an orthopedic bed.


Intraspinal tumors of the cervical tract. A study of 68 cases.


Pulmonary arteriovenous fistula.

Pulmonary arteriovenous fistula.


Whiplash injury of neck--fact or fancy.

Whiplash injury of neck--fact or fancy.


On the dumping syndrome as one of the postcibal syndromes after gastric resection.


Endocrinological studies on acute intestinal obstruction.


Hydatid cyst of bone. Case report.

Hydatid cyst of bone. Case report.


Small gut obstruction due to food.

Small gut obstruction due to food.


Nuclear magnetic resonance study of the protolysis kinetics of the peptide hydrogens of triglycine.


Transfer reactions involving boron. VI. Physical characterization and chemical properties of aryl- and alkylthioboranes.


Some aspects of mechanism and catalysis for carbonyl addition reactions.


Synthesis of the carboxyl-terminal heptapeptide sequence of bovine pancreatic ribonuclease.


Estimation of sugar in ascitic fluid and blood. Its diagnostic importance in tuberculous ascites.


Bone marrow studies in malignant neoplastic diseases.


Effect of premedication on the safety index of ether, chloroform and halothan in mice.


Financing of medical care in India. The need for pilot studies.


Intestinal amoebiasis. Some observations on the laboratory techniques in the diagnosis.


Anti-H in a family. Report of two cases.


Peutz-Jeghers syndrome. Report of a case.


Spontaneous rupture of the spleen complicating infectious mononucleosis.


Lymphadenopathy due to intramuscular iron.


The contemporary surgical scene in India.


Studies in sickle cell anemia. XXIX. Pathological aspects of osseous changes.


Practical evaluation of lung function in the physician's office.


Pyloric stenosis. The incidence of infantile hypertrophic pyloric stenosis in the Negro infant.


Aging in human joints. II. Joint capsule.


The treatment of atherosclerotic peripheral arterial insufficiency with low molecular weight dextran intravenously.


Sarcoid cardiomyopathy.

Sarcoid cardiomyopathy.


The hospital psychiatrist's role in community psychiatry.


New perspectives on cancer with species specific reactivity.


Changing role of a mental hygiene clinic in response to community needs.


Anaphylactoid purpura; a case report.

Anaphylactoid purpura; a case report.


Rethinking our goals for integrated health services.


The white house conference "To Fulfill These Rights". The ninth imhotep conference.


NMA Leadership in Mississippi.

NMA Leadership in Mississippi.


Absorption of protein and fat in dogs with interrupted mesenteric lymphatics.


Electron microscopy of cirrhotic nodule Tubularization of the parenchyma by biliary hepatocytes.


Ferric glycerophosphate-induced hyperplasia of the rabbit parathyroid gland. An ultrastructural study.


Degraded tetracycline nephropathy. Functional, morphologic, and histochemical observations.


Diabetic sclerosis of the renal juxtaglomerular apparatus.


The transport of ferritin across the placenta of the rat.


Ultrastructure of the human placenta in maternal diabetes mellitus.


More mercury poisoning cases.

More mercury poisoning cases.


Close tolerance cooling apparatus for cryobiological studies.


X-ray treatment of cancer of the larynx in patients with tuberculosis of the lungs.


The influence of polyols on the course of experimental radiation disease.


Effects of facilitating, neutral and inhibiting instructions on perceptual tasks following brain damage.


Aspects of the criterion problem in small group research. II. The analysis of group tasks.


Constancy and contrast. 3A.

Constancy and contrast. 3A.


Studies on the antituberculous activity of alpha-ethyl-thioisonicotinamide-methanesulfonate and its side effects.


On a cause of postoperative transient hypoalbuminemia (inadequateness of homologous serum albumin for the host).


Polyps.

Polyps.


The treatment of diverticulitis of the colon.


Partial gastrectomy. The late nutritional and metabolic effects.


Business in medicine (not monkey business).


Captain of the ship doctrine.

Captain of the ship doctrine.


Some facets of medical malpractice--pertaining to liability in cardiac arrest.


A critical analysis of aortoiliopelvic lymphadenectomy and high ligation of the inferior mesenteric artery for carcinoma of the left colon and rectum.


The contribution of micro-vascular surgery to esophageal replacement.


Effects of bacterial flora on survival of rats with strangulation obstruction.


Nonsuture intestinal anastomosis.

Nonsuture intestinal anastomosis.


Pneumoperitoneum in the newborn.

Pneumoperitoneum in the newborn. Between 1947 and 1964, 32 infants in the first two weeks of life were seen at The Hospital for Sick Children, Toronto, with radiological evidence of free air in the peritoneal cavity. The clinical picture and the radiological signs in these infants are described. Perforations were found at all levels of the gastrointestinal tract. The overall mortality rate was 59%. The stomach was the most common site of perforation; it occurred in 11 children, of whom five survived. Prompt surgery was essential for survival, but when immediate laparotomy is not practical, abdominal paracentesis may prove to be life-saving.


"Skid row" syndrome: a medical profile of the chronic drunkenness offender. From skid row, 227 chronic "drunks", inmates of the Toronto Jail, were studied to determine the physical features and illnesses of this group. Complete physical examinations, liver function tests, routine hematology, urinalysis, chest radiographs were carried out and previous hospital records were obtained for each man. The data were analyzed by IBM computer and reported in terms of body systems. Items that occurred in sufficient frequency were separated out and listed to compile a "skid row" syndrome. The men averaged 45 years of age, had been drinking heavily for 20 years and had four drunken convictions a year. Tuberculosis was found in 8.8%. Epilepsy was confirmed in 8%. Cirrhosis of the liver was definite in 3% of the group; 75% were under the Canadian average weight, and 25% had significant body deformities. It was estimated that, if necessary therapy was carried out, 90% of the men would be able to perform useful labour.


Learning while serving in Tanzania.

Learning while serving in Tanzania.


Subcutaneous nocardiosis.

Subcutaneous nocardiosis.


Colon interposition following esophagogastrectomy.


Transferrin deficiency associated with nephrotic syndrome.


The treatment of diabetes mellitus with a retard form of butylbiguanide.


Latent diabetes mellitus in the parents of juvenile diabetics.


Resuscitation after drowning in freezing water.


The sequelae and prognosis of unresolved virus hepatitis in childhood.


The upper limit of the normal glucose concentration in the urine of healthy persons.


A brief history of the postgraduate medical school.


Copper content in brains with blood-brain barrier damaged by freezing, hemorrhage and encephalomalacia (experimental work).


Prognosis and treatment of primary biliary cirrhosis.


Primary biliary cirrhosis.

Primary biliary cirrhosis.


The late results of long-term treatment of primary biliary cirrhosis by corticosteroids.


Electron microscopical studies on the liver cells in hyperplastic nodules of human cirrhosis.


On the pathogenesis of the cholestasis induced by 17.alkylated steroids: ultrastructural and functional changes of the liver cells during the treatment.


Studies on the chemotherapy of biliary tract infection.


Some aspects of amoebic dysentery and hepatic amoebiasis in Lagos.


The use of the vacuum extractor in the tropics.


The hazards of "D. & C." operation.

The hazards of "D. & C." operation.


Fibroid polypi.

Fibroid polypi.


A short history of the Danish Mission Hospital, Numan, Sudan, United Mission.


Psychiatric disorders in the aged: epidemiology and preventive measures.


A case of systemic lupus erythematosus.

A case of systemic lupus erythematosus.


Shigella flexneri bacteraemia: report of a case.


Arterial hypertension in the Lagos University Teaching Hospital.


Function of isolated dog kidneys under conditions of perfusion with heterologous blood.


Primary pulmonary hypertension in five patients.


Pressure and shearing forces as stimuli of labyrinthine epithelium.


Cigarettes, cough, and cancer of the lung.


Incus homografts in chronic ear surgery.


Inner ear pathology after experimental stapedectomy.


Histopathological changes following bilateral stapedectomy.


Acoustic effects of removing the malleus head.


Latency of the stapedius muscle reflex in man.


Treatment of vertigo using the ultrasonic generator.


Malignant neoplasm around the cribriform plate.


Oncocytoma of the submaxillary salivary gland. Report of a case.


Carcinoma of the maxillary sinus.

Carcinoma of the maxillary sinus.


Evaluation of the patient with otoneurologic disease.


The effects of high hydrostatic pressure on coliphage T-4.


Small-angle scattering of apoferritin in solution.


The binding properties of rat-liver ribosomes: complexes formed with cytochrome c.


Counter-current distribution of red blood cells of slightly different ages.


Molecular structure of polyglycine II.

Molecular structure of polyglycine II.


The effect of glucose on hydrogenase activity in Chlorella.


A high-potential non-haem iron protein from the facultative photoheterotrophe Rhodopseudomonas gelatinosa.


Pressure effect on deoxyribonucleic acid transition.


Biosynthesis of glutamate in photosynthetic bacteria.


Photoreversible pigment transformations in etiolated plants.


Kinetic studies on the oxidase systems of photosynthetic bacteria.


The taxonomic distribution of plastoquinone and tocopherolquinone and their intracellular distribution in leaves of Vicia faba L.


Some photochemical properties of chloroplast preparations from the chrysomonad Hymenomonas sp.


The relation between structure and pigments during the first stages of proplastid greening.


The existence of chlorophyll aggregates at room temperature in vivo and in vitro.


Carbohydrate transport in Staphylococcus aureus. 3. Studies of the transport process.


Concerning the molecular weight, shape, and size of polyglucose isolated from HeLa cells.


Inhibition studies of photophosphorylation by Rhodospilillum rubrum chromatophores with particular concerns to antimycin-resistant photophosphorylation in the presence of artificial electron carriers.


A novel spot test for iron.

A novel spot test for iron.


A synthesis of oestrone via novel intermediates.


The absolute configuration of (+)-1,2,3,4-tetrahydroharmine.


Selective reduction of a dicarboxylic acid.


The preparation of liquid halothane standards for gas chromatography.


A report of the Committee on The Incorporation of Clinical Laboratories.


A diamond knife in the cataract incision.


Medical management of multiple sclerosis.


Diseases of the chest in Israel.

Diseases of the chest in Israel.


Kinking of aortic arch with aneurysmal dilatation. Report of a case.


Differential forced expiratory spirograms. A bronchospirometric study.


Taussig-bing complex with pulmonary stenosis.


A study of the ventriculophasic phenomenon in paroxysmal atrial tachycardia with block.


Evaluation of a new mucolytic agent.

Evaluation of a new mucolytic agent.


The right middle lobe syndrome, a non-obstructive complex.


Isolated disease of the middle lobe and lingula.


The effect of dimethyl sulfoxide on the myocardium during hypothermic preservation of the heart.


A physiologic roentgenographic disparity in sarcoidosis.


Hyperpotassemia and hypercalcemia.

Hyperpotassemia and hypercalcemia.


Goodpasture's syndrome.

Goodpasture's syndrome.


Hemolytic anemia with aortic ball-valve prosthesis. Report of a case.


Single cell analysis of sensory interaction in anterior lateral and suprasylvian gyri of the cat cerebral cortex.


Steady potential fields during sleep and wakefulness in the cat.


Multimodal sensory activation of cells in the magnocellular medial geniculate nucleus.


Exchange of sodium in the isolated brain of the frog.


Production and prevention of intracranial venous thromboses in the rat.


Transmembrane potentials of human muscle cells in vivo.


Afferent and efferent activity in single units of the cat's optic nerve.


Retinal receptive field changes produced by auditory and somatic stimulation.


Restoration of visual acuity after optic nerve section and regeneration, in Astronotus ocellatus.


Trends in community mental health programs.


Planning a children's treatment center.

Planning a children's treatment center.


Mental disease and its medical model.

Mental disease and its medical model.


Optimum services for the mentally retarded.


Discharge against medical advice. The doctor's role.


An intake service in a private psychiatric hospital.


Principles versus practice in nursing education.


Patient council gets results.

Patient council gets results.


Dietary aftercare.

Dietary aftercare.


Infrared radiant energy and oscillations of the corneoretinal potential in man.


The selenium content of tissues of the human eye.


Midbrain electrical fields produced by stimulation of the muscle branches of the oculomotor nerve.


Determination of tear volume and tear flow.


Regional differences in protein synthesis within the lens of the rat.


Conversion of soluble lens protein to albuminoid.


Effect of aqueous-venous shunt on rabbit eyes.


Changes in outflow facility and content of norepinephrine in iris and ciliary processes of albino rabbits after cervical ganglionectomy.


Activity of ornithine-carbamyltransferase (OCT) in the blood serum of children with rheumatic diseases.


Proteins in 6-M guanidine hydrochloride. Demonstration of random coil behavior.


The effect of an atherogenic diet on plasma lipid composition and aortic atherosis in two strains of New Zealand White rabbit.


Rabbit kidney vacuolating virus: ultrastructural studies.


Serum aldolase in tetanus.

Serum aldolase in tetanus.


The lipids and pigments of the chloragosomes of the earthworm Lumbricus terrestris L.


Ambulatory treatment of pulmonary tuberculosis. A clinical evaluation of 1684 patients.


Ultrastructure of the myeloma cell.

Ultrastructure of the myeloma cell.


Cardiac monitors work--but they should report more than they do.


Avoidance of routine catheterization before gynaecological laparotomy.


On peripheral embolectomy.

On peripheral embolectomy.


Experimental studies on the transfusion of blood obtained postmortem.


Psychiatric syndromes in children and their relation to family background.


Stability in psychiatric diagnoses from hospital admission to discharge.


Effects of drugs on the histologically visualized catecholamines of the adrenal medulla of the rat.


Standards for the employment of former mental hospital patients.


Amyloidosis of the skin.

Amyloidosis of the skin.


Portal hypertension. 4. Nursing the patient with portal hypertension.


Effects of exercise on oxidative activities in rat liver mitochondria.


Chronic hyperosmolality. A condition resulting from absence of thirst, defective osmoregulation, and limited ability to concentrate urine.


Functional devices for use on the lower extremity.


Hemolytic anemia and thrombocytopenia in a case of left atrial myxoma associated with mitral stenosis.


Platelet function tests in thrombocythaemia and thrombocytosis.


Malignant change in ulcerative colitis.

Malignant change in ulcerative colitis.


Origin of milk cholesterol in the rat: dietary versus endogenous  sources. Slices of mammary gland from lactating rats, incubated with acetate-1-(14)C or mevalonate-2-(14)C, synthesized cholesterol-(14)C. Within 2 min of an intravenous injection of 1 ml of a suspension of chylomicrons containing cholesterol-4-(14)C, mammary glands of lactating rats removed as much as 29% of the labeled cholesterol; those of 2-day-postlactating rats removed none. Rats were fed a diet containing 0.05% cholesterol-4-(14)C from 7 days prepartum to 20 days postpartum. At isotopic equilibrium, the relative specific activities of milk and dietary cholesterol indicated a dietary origin for 11% of the milk cholesterol. The extent to which endogenous sources-liver and mammary gland-contributed cholesterol to milk proved entirely dependent on whether dietary cholesterol, in the form of chyle lipo-proteins, was first processed by liver or taken up directly by mammary gland. Lack of information regarding the extent to which chyle cholesterol is removed from blood under physiological conditions by mammary gland and other tissues precludes precise assessment of the endogenous contributions to milk cholesterol and, moreover, casts doubt on the quantitative interpretability of cholesterol-(14)C-feeding experiments reported in the literature.


Drug preservatives and uterine contractility.


Fetal outcome in the diabetic pregnancy.


An analysis of archery.

An analysis of archery.


Corrective bracing needs of the rheumatoid arthritic wrist.


Comparative effects of two benzodiazepine compounds on isolated human myometrium.


Histochemistry of hydrolytic and oxidative enzymes in the human and experimentally induced adenocarcinoma of the endometrium.


Rabies exposure and treatment of Illinois veterinarians.


Improved diagnostic methods needed for equine piroplasmosis and anemia.


Status of state-federal hog cholera eradication program.


World situation on hog cholera and African swine fever.


Candicidin therapy for mycotic dermatoses in dogs and cats.


Surgical treatment of aortic embolism in the cat.


Surgical correction of esophageal stenosis in the dog.


Activity of supraoptic nucleus neurons of the hypothalamus.


Stomach ulcers in farrowing gilts.

Stomach ulcers in farrowing gilts.


Anticonvulsant and psychotropic action of tegretol. A preliminary report.


Quantitation of Meissner's corpuscles in hereditary neurologic disorders. Charcot-Marie-Tooth disease, Roussy-Levy syndrome, Dejerine-Sottas disease, hereditary sensory neuropathy, spinocerebellar degenerations, and hereditary spastic paraplegia.


Chronic infection of the central nervous system with rubella virus.


The nature of the narcoleptic sleep attack.


A quantitative study of Meissner's corpuscles in man.


A comparative electromyographic study of the reactions to passive movement in parkinsonism and in normal subjects.


On the origin of focal motor epilepsy.

On the origin of focal motor epilepsy.


Voltage-time characteristics of spikes and other rapid electroencephalographic transients: semantic and morphological considerations.


Spinal cord infarction occurring during insertion of aortic graft.


Myasthenia gravis occurring in families.


Clivus meningiomas.

Clivus meningiomas.


A pediatrician's checklist for adolescents.


Community clinic treatment for back-ward patients.


Fish protein concentrates in the treatment of kwashiorkor.


Familial vitamin D resistant rickets in untreated adult. Bony proliferation of neural arches with cord compression.


Effect of tranquilizing drugs on postnatal behavior.


Fathers in the delivery room --an opposition standpoint.


Fathers in the delivery--"helpful and supportive".


"Return the joy of home delivery" with fathers in the delivery room.


Fathers in the delivery room-- long experience molds one viewpoint.


Doctors--we need you.

Doctors--we need you.


Pharmacological blockade of ovulation in the ewe.


Some factors affecting the response of the immature mouse to pregnant mare serum gonadotrophin and human chorionic gonadotrophin.


The metabolism of cortisol by human extra-hepatic tissues.


Aromatization of 7-alpha-hydroxydehydroepiandrosterone and of its 3-sulphate by ovarian and placental tissue cultures.


Metabolic and endocrine effects of lysergic acid diethylamide (LSD-25) on male rats.


Mutation frequencies detected following irradiation of virgin and inseminated Drosophila melanogaster females.


Relationship of fractons of soybeans and a crystalline soybean trypsin inhibitor to the effects of feeding unheated soybean meal to chicks.


An approach to quantitative analysis of intrauterine pressure data.


Comparison of neutral fat and free fatty acids in high lipid-low carbohydrate diets for the growing chicken.


Twinning in relation to birth weight, mortality, and congenital anomalies.


Breast engorgement and postpartum fever.


Evolution of a placenta circumvallata.

Evolution of a placenta circumvallata.


Ovarian carcinoma. The problems of staging and grading.


Sequential estrogen-progestogen therapy in gynecology.


Oxytocin induction in pregnant rabbits, with special reference to the stillbirth rate.


The pregnant addict. A study of 66 case histories, 1950-1959.


Significance of a single umbilical artery. Report from the collaborative study of cerebral palsy.


Perforated peptic ulcer in pregnancy.

Perforated peptic ulcer in pregnancy.


Poverty as an isolated factor in relation to perinatal asphyxia.


Perforation of the postpartum uterus with an intrauterine contraceptive device. A case of perforation of the uterus at the time of insertion of the Birnberg bow IUD in a lactating, amenorrheic woman is presented.  The patient, a 25-year-old gravida 2, had the IUD inserted 2 months after delivery.  Perforation occurred at the time of insertion, causing a 2 mm puncture wound in the fundus.  It appeared that the perforation was caused by the expulsion of the bow from the introducer, not by uterine dilation.  Although the patient's uterus appeared grossly normal and well involuted, it was extremely soft.  This case raises questions about the timing of the insertion of an IUD in a lactating, amenorrheic woman.  It has been commonly assumed that involution requires about 6 weeks and that lactation speeds this process.  However, it is recommended that this assumption be reassessed and that insertion of any IUD be delayed until regular menses have been re-established.


Congenital heart disease, deaf-mutism and associated somatic malformations occurring in several members of one family.


Toward a community alcoholism program.

Toward a community alcoholism program.


Cases 8 and 9. Anesthesia accidents.

Cases 8 and 9. Anesthesia accidents.


Gynaecological pain.

Gynaecological pain.


Profileplasty.

Profileplasty.


Hypertrophic obstructive cardiomyopathy.


Oral contraceptives, thrombosis, and cyclical factors affecting veins.


Lathyrism in the fetal rat. Evidence for impairment of elastin formation.


Fat absorption: a transport problem.

Fat absorption: a transport problem.


Intracranial teratomas in fetal life and infancy.


Maternal serum screening for irregular antibodies.


The place of surgery in hypertrophic obstructive cardiomyopathy (idiopathic hypertrophic subaortic stenosis).


Right ventricular obstruction resulting from anomalous muscle bundles.


Modification and maintenance of behavior through systematic application of consequences.


Personality patterns of pupils in special classes for the emotionally disturbed.


The treatment of autoimmune hemolytic anemia with heparin.


Reconstructive tubal surgery.

Reconstructive tubal surgery.


A plan for the recognition and management of addictions.


The psychiatry of presidential assassination. 3. The Roosevelts.


Corpora lutea in proven mules.

Corpora lutea in proven mules.


The menstrual cycle and its hormonal control.


Florida's family planning program.

Florida's family planning program.


A "package" plan for extension of birth control services.


Family planning in Maryland.

Family planning in Maryland.


The Alameda County Health Department family planning program.


The birth control program in the Mecklenburg County Health Department.


The organization of a pilot family planning clinic in Tennessee.


Family planning in the Nation's Capital.


Family planning clinics for the urban fringe.


Participation of area hospitals in family planning.


The education of health experts for the 1970's.


Evaluation of recent developments in contraceptive technology.


The development of family planning services by state and local health departments in the United States.


Population growth--a challenge to public health.


Population growth, problems, and trends in the United States.


Fibromuscular hyperplasia of the renal artery: an enigma.


Pathologic findings in swine affected with a virulent strain of Aujeszky's virus.


A cerebrospinal angiopathy in pigs.

A cerebrospinal angiopathy in pigs.


How to cultivate the slime molds and perform experiments on them.


Adaptations to cold.

Adaptations to cold.


Foetus and newborn.

Foetus and newborn.


Advances in laryngeal physiology and their clinical application.


Cystic fibrosis with extensive fat replacement of the liver.


Equine centrilobular emphysema. With further observations on the pathology of heaves.


Naturally occurring emphysema, the fine gross and histopathologic counterpart of human emphysema.


Reports of wives of alcoholics of effects of LSD-25 treatment of their husbands.


Effects of clomiphene citrate on endometrial hyperplasia in the premenopausal female.


Health care insurance for retired employees.


Cephalic circulation and oxygen consumption before and after birth.


Oxygen consumption of arterial smooth muscle as a function of active tone and passive stretch.


Spontaneous tumors of the thyroid gland in mice.


Evidence for the release of bradykinin in carcinoid syndrome.


Pyloric stenosis in the dog caused by hypertrophy of the circular muscle of the pylorus.


Jaagsiekte--a hazard of intensified sheep husbandry.


An outbreak of Salmonella dublin infection in chinchillas.


Formalin inactivated foot-and-mouth disease vaccines prepared on an industrial scale. I. Production.


Medicare: its meaning for public health.


Prolonged use of methyldopa in severe hypertension in pregnancy.


Steroid biosynthesis by human ovarian granulosa and thecal cells.


A new and simple method for the determination of thyroxine in serum.


Western equine encephalomyelitis in a Florida horse.


Replantation of uterus and ovaries in dogs, with successful pregnancy.


Influenza and its complications. II.

Influenza and its complications. II.


An electron microscope study of squamous cell carcinoma in merino sheep associated with keratin-filled cysts of the skin.


Lymphatics of the heart.

Lymphatics of the heart.


Cirrhosis of liver simulating congenital cyanotic heart disease.


Some animal experiments pertinent to the problem of combining psychotherapy with drug therapy.


Milk-ejection activity (oxytocin) in the external jugular vein blood of the cow, goat and sow, in relation to the stimulus of milking or suckling.


Observations on laboratory rodents treated with "rifamide" during pregnancy.


Leukocyte abnormalities in familial amaurotic idiocy.


Sexual dysfunction following rectal excision for ulcerative colitis.


Ulcer cancer of the duodenum.

Ulcer cancer of the duodenum.


Effect of internal temperature on eating quality of pork chops.


Laboratory animal care.

Laboratory animal care.


Teratogenic studies and their clinical relevance.


Kittens as experimental model for study of kernicterus.


The community mental health center--a public health facility.


Health orientation and medical care.

Health orientation and medical care.


Iliofemoral veno-occlusive disease. Results with thrombectomy in 16 cases.


Preparation for childbirth. A review.

Preparation for childbirth. A review.


Similarity, contrast, and complementarity in friendship choice.


The effect of a physical fitness developmental program on self-concept, mental age and job proficiency in the mentally retarded. A pilot study in corrective therapy.


Serum C-reactive protein in infections during the first six months of life.


Visual responses in the newborn.

Visual responses in the newborn.


The effect of activity on the concentration of blood lactate in newborn infants.


Diagnosis and management: congenital rubella.


Platelet survival studies in Aldrich syndrome.


Prediction of responses to multidimensional from responses to unidimensional stimuli.


Children's expression of like-dislike and their responses to color in the Rorschach.


Feedback for planning.

Feedback for planning.


Partial nodular transformation of the liver with portal hypertension.


Hypercalcemia and hypertension.

Hypercalcemia and hypertension.


Fighting and avoidance in response to aversive stimulation.


The occurrence of L-lanthionine in the amino-acid pool of insects.


Phosphoenolpyruvate carboxykinase in gluconeogenesis and its repression by hexoses.


The important "ten B's" of post-partum hospital care.


Perinatal death due to anoxia.

Perinatal death due to anoxia.


Selective gestational psychosis. A case report.


Respiratory virus infections in man and animals. Equine influenza viruses isolated at Cambridge in 1963 and 1965.


Population dynamics and disease.

Population dynamics and disease.


Catastrophes in labour. Rupture of the uterus.


Trehalase from Dictyostelium discoideum: purification and properties. The hydrolytic enzyme, trehalase, was isolated and purified approximately 90-fold from the cellular slime mold Dictyostelium discoideum. The purified trehalase has an optimal temperature of 45 degrees C and shows maximum activity at pH 5.5 in citrate buffer. Its Michaelis constant is 1.2x 10(-3)M.


Limitations of footprinting as a means of infant identification.


The management of cancer of the body of the uterus.


The management of cancer of the prostate.


Radiologic signs of hydromyelia.

Radiologic signs of hydromyelia.


The uranediol rearrangement.

The uranediol rearrangement.


Six cases of hypertensive crisis in patients on tranylcypromine after eating chicken livers.


Perinatal mortality study. Erythroblastosis fetalis.


Electron microscopic observations on antibody-producing lymph node cells. Lymph node cells of rabbits injected with sheep erythrocytes, identified as antibody-producing by their ability to produce plaques of hemolysis in erythrocyte-containing agar layers, have been examined by electron microscopy, by the use of a procedure devised for subjecting single cells to such examination. The antibody-producing cells thus examined were found to fall into two classes, according to the current terminology: some were in the category of lymphocytes, and others, in the category of plasma cells. Within each class, cells were found to vary in certain characteristics, especially in the degree of development of such organelles as the nucleolus, Golgi apparatus, and the endoplasmic reticulum. In the case of the endoplasmic reticulum especially, it could be seen that a series of these plaque-producing cells, ranked in order of increasing size and development of the endoplasmic reticulum, would extend over a considerable range from those lymphocytes with the least developed organelles to the mature plasma cells with the greatest development of these structures.


"Gold nephrosis".

"Gold nephrosis".


Discussion of Dr. Solnit's paper "Who Deserves Child Psychiatry? A Study in Priorities".


An episode of food poisoning attributed to imported mushrooms.


President's page.

President's page.


Interferon production in chick embryo cells. II. The role of DNA.


Game utilization in the serengeti: preliminary investigations. II. Wildebeeste.