A study on the electrical resistance of the frog sartorius muscle. Four different methods of measuring the resistance of a muscle fiber have been applied to the frog sartorius muscle. The methods, in which the resistance of the microelectrode entered the calculation of the effective resistance of the fiber, resulted in values which were 8 times higher than the resistance values obtained with methods independent of the electrode resistance. A simple cable model of a muscle fiber could not account for the discrepancy in the effective resistance found in these measurements; therefore, an enlarged cable model for a muscle fiber has been proposed, and its biological implications have been discussed. The effective resistance (measured with the two different groups of methods) decreased when the potassium concentration in the bath increased. Using the proposed enlarged cable model for the interpretation of these results, it is shown that not only the membrane resistance but also the myoplasmic resistance decreases with an increasing potassium concentration in the Ringer solution.


A kinetic model for adaptation and the light responses of Phycomyces. A kinetic model is described consisting of two sequential first order processes connected by two parallel reaction pathways, one of which is light-catalyzed. A change in light flux changes the rate constant of the light-dependent process, whereupon the levels of two chemical intermediaries readjust. The model's output duplicates all the main features of the cell's light-growth and dark-growth responses except their latent periods. An asymmetric modification of the model reproduces the two types of phototropic inversion discovered by Reichardt and Varjú and by Dennison. Simple exponential equations describe these responses of the model, as well as the theoretical course of its light and dark adaptation. It is concluded that adaptation in Phycomyces consist in the photocatalytic adjustment of the level of a metabolic reservoir.


Amino acid and sugar transport in rabbit ileum. L-Alanine and 3-O-methyl-D-glucose accumulation by mucosal strips from rabbit ileum has been investigated with particular emphasis on the interaction between Na and these transport processes. L-Alanine is rapidly accumulated by mucosal tissue and intracellular concentrations of approximately 50 mM are reached within 30 min when extracellular L-alanine concentration is 5 mM. Evidence is presented that intracellular alanine exists in an unbound, osmotically active form and that accumulation is an active transport process. In the absence of extracellular Na, the final ratio of intracellular to extracellular L-alanine does not differ significantly from unity and the rate of net uptake is markedly inhibited. Amino acid accumulation is also inhibited by 5 x 10(-5)M ouabain. 3-O-methyl-D-glucose accumulation by this preparation is similarly affected by ouabain and by incubation in a Na-free medium. The effects of amino acid accumulation, of ouabain, and of incubation in a Na-free medium on cell water content and intracellular Na and K concentrations have also been investigated. These results are discussed with reference to the two hypotheses which have been suggested to explain the interaction between Na and intestinal nonelectrolyte transport.


Potential, current, and ionic fluxes across the isolated retinal pigment epithelium and choriod. A flux chamber was utilized for in vitro studies of a membrane formed by the retinal pigment epithelium and choroid of the eye of the toad (Bufo arenarum and Bufo marinus). A transmembrane potential of 20 to 30 mv was found, the pigment epithelium surface positive with respect to the choroidal surface. Unidirectional fluxes of chloride, sodium, potassium, and calcium were determined in the absence of an electrochemical potential difference. A net transfer of chloride from pigment epithelium to choroid accounted for a major fraction of the mean short-circuit current. A small net flux of sodium from choroid to pigment epithelium was detected in Bufo marinus. In both species of toads, however, about one-third of the mean short-circuit current remained unaccounted for. Manometric determinations of bicarbonate suggested an uptake of this ion at the epithelial surface of the membrane but did not provide evidence of a relationship between this process and the short-circuit current.


Relationship between oxygen consumption and hypoxia in sheep with different haemoglobins.


Theoretical effect of temperature on threshold in the Hodgkin-Huxley nerve model. In the squid giant axon, Sjodin and Mullins (1958), using 1 msec duration pulses, found a decrease of threshold with increasing temperature, while Guttman (1962), using 100 msec pulses, found an increase. Both results are qualitatively predicted by the Hodgkin-Huxley model. The threshold vs. temperature curve varies so much with the assumptions made regarding the temperature-dependence of the membrane ionic conductances that quantitative comparison between theory and experiment is not yet possible. For very short pulses, increasing temperature has two effects. (1) At lower temperatures the decrease of relaxation time of Na activation (m) relative to the electrical (RC) relaxation time favors excitation and decreases threshold. (2) For higher temperatures, effect (1) saturates, but the decreasing relaxation times of Na inactivation (h) and K activation (n) factor accommodation and increased threshold. The result is a U-shaped threshold temperature curve. R. Guttman has obtained such U-shaped curves for 50 microsec pulses. Assuming higher ionic conductances decreases the electrical relaxation time and shifts the curve to the right along the temperature axis. Making the conductances increase with temperature flattens the curve. Using very long pulses favors effect (2) over (1) and makes threshold increase monotonically with temperature.


The effect of calcium on the desensitization of membrane receptors at the neuromuscular junction. Desensitization, as represented by the progressive decline in the electromotive effects of depolarizing agents at the neuromuscular junction, was studied by observing the time course of changes in effective transmembrane resistance during the prolonged application of 0.27 mM carbamylcholine to the postjunctional region of frog skeletal muscle fibers. The effective transmembrane resistance was measured by means of two intracellular microelectrodes implanted in the junctional region of single muscle fibers. When carbamylcholine was applied to the muscle there was an immediate decrease in the effective membrane resistance followed by a slower return toward control values which was identified as the phase of desensitization. When the calcium concentration was increased from 0 to 10 mM there was an approximately sevenfold increase in the rate of desensitization. On the other hand, an increase in the concentration of sodium from 28 to 120 mM caused a slowing of the rate of desensitization. Even in muscles depolarized by potassium sulfate, calcium increased the rate of desensitization while high concentrations of potassium tended to prolong the process. Some mechanisms by which calcium might exert these effects are discussed.


Topochemical factors in potentiation of contraction by heavy metal cations. In addition to the previously studied Zn(2+), low concentrations (about 0.5 mM) of Be(2+), Ba(2+), Cd(2+), Ni(2+), Cu(2+), Pt(4+) and, outstandingly, 0.5 microM of UO(2) (2+), potentiate the twitch of frog sartorius and toe muscles by prolonging the active state of contraction. The degree of potentiation is a roughly S-shaped function of p(metal(2+)), suggesting that each metal binds to a ligand of the muscle fiber, representative apparent affinity constants being: UO(2) (2+), 5 x 10(6); Zn(2+), 2.8 x 10(5); and Cd(2+), 2 x 10(4). UO(2) (2+) potentiation effects are rapidly reversed by PO(4), and Zn(2+) and Cd(2+) effects by EDTA, PO(4), and cysteine. The rapidity of these reversals by the nonpenetrating EDTA and PO(4), and the fact that heavy metal ions evidently potentiate by prolonging the action potential, indicate that the metal potentiators exert their primary action at readily accessible (i.e. plasma and T tubular) membrane sites. The relatively slow kinetics of development of potentiation, and the even slower reversal of it in pure Ringer's solution, indicate that the metal ions are bound to connective tissue, as well as to muscle fibers. The binding effects at the readily accessible membrane sites evidently impairs delayed rectification and thus modifies the action potential and excitation-contraction coupling so as to cause potentiation. SH is excluded, and PO(4) and imidazole are possibilities, as the membrane ligand binding the potentiating metal ions.


A specific kind of noradrenaline granules in the vesicular gland and the vas deferens of the bull.


Blockage of sodium conductance increase in lobster giant axon by tarichatoxin (tetrodotoxin). Tarichatoxin, isolated from California newt eggs, has been found to selectively block the increase of sodium conductance associated with excitation in lobster giant axons at nanomolar concentrations. This resulted from a reduction in the amplitude of the conductance increase rather than a change in its temporal characteristics. The normal potassium conductance increase with depolarization is not altered. A high concentration of calcium applied concomitantly with the toxin significantly improves the reversibility of the sodium blocking. This toxin has recently been identified as chemically identical with tetrodotoxin from the puffer fish. Toxins from the two sources are equally effective and are shown to have an action which is distinctly different from that of procaine.


Stimulation of positively and negatively reinforcing sites in the avian brain.


The electropotential difference between the blastocoel and the external medium in the amphibian embryo: its similarity to the adult frog trans-skin potential.


Phosphatides of rat liver nuclei.

Phosphatides of rat liver nuclei.


Separation of plasminogen activators from normal and lytic human plasma.


The effect of alpha-methyl-tyrosine on peripheral sympathetic transmission.


Negative capacitance solid state microelectrode input circuit for use in neurophysiology.


The mechanism of action of anticonvulsants. II. Acetazolamide.


Lipoproteins in the vessel wall.

Lipoproteins in the vessel wall.


Transplantation antigen of mice: cellular localization of antigen determined by the H-2 locus.


Serological analysis of a recombination in the H-2 region of the mouse.


The murine Y chromosome as a marker.

The murine Y chromosome as a marker.


The effect of polymorphonuclear leucocytes on the blastoid transformation of lymphocytes in mixed leucocyte cultures.


Studies on the degradation of succinylcholine chloride in bovine serum and tissues.


An antigenic analysis of Vibrio fetus. 3. Chemical, biologic, and antigenic properties of the endotoxin.


Experimental Ostertagia ostertagi infections in calves: parasitology and pathogenesis of a single infection.


Semipermanent extracorporeal arteriovenous and thoracic duct-venous shunts in cattle.


Chromosomal variations in a pig kidney cell line persistently infected with hog cholera virus.


Anal sacs of the cat (Felis domesticus).


Reovirus type 1 in laboratory dogs.

Reovirus type 1 in laboratory dogs.


Effects of antimicrobial agents on leptospiral growth, respiration, motility, and viability.


The effects of feeding rabbits a vitamin E-low diet containing oleic acid.


Use of the electronic computer in retrieval of veterinary pathologic data.


Some effects of feeding products high in naturally occurring thyroactive compounds upon reproduction of mink (Mustela vison).


Pumpoxygenator support under increased atmospheric pressure in case of impaired diffusion capacity of the lungs.


Splenectomy.

Splenectomy.


Metabolic effects noted during hypothermic total body perfusion at increased ambient pressures. I. Using high flow rates.


Metabolic effects of hypothermic total body perfusion at increased ambient pressures. II. Reduced flow rates.


The combination of Sprengel's deformity with Klippel-Feil disease and the presence of an os omovertebrale.


The metabolism of metronidazole (1-2'-hydroxyethyl-2-methyl-5-nitroimidazole).


The effect of aminooxyacetic acid on the metabolism of gamma-aminobutyric acid in brain.


The metabolism of acetophenetidin and N-acetyl-p-aminophenol in the cat.


Esterases and neurotoxicity of some organophosphorus compounds.


The relative toxicites of methotrexate and aminopterin.


The effect of the optical isomers of alpha-methyl-p-tyrosine upon brain and heart catecholamines in the mouse.


The surface activity of phenothiazine derivatives at the air-solution interface.


Methylation of desmethylimipramine by rabbit lung in vitro.


Influence of intraperitoneally administered amino acids on amino acid patterns of Ehrlich ascites tumor cells and brain in mice.


Metabolic studies of tetrabenazine, a psychotropic drug in animals and man.


The uptake of conjugated bilirubin by rat liver.


Computers, the second revolution in statistics.


Elimination of variates in linear discrimination problems.


Linear relationships between variables affected by errors.


The study on the insulin controlling and directing of chlorpromazine action and level in brain tissue.


Fitting curves to longitudinal data.

Fitting curves to longitudinal data.


Designs for sequences of treatments with carry-over effects.


Characteristics of a ratio used to estimate failure rates: occurrences per person year of exposure.


Planning a quantal assay of potency.

Planning a quantal assay of potency.


A test for equal catchability.

A test for equal catchability.


Stereoscopic models of multivariate statistical data.


Balanced incomplete block designs with double grouping of blocks into replications.


Estimation of crop yields for small areas.


Sampling techniques for estimation of incidence of Red spider mite on tea crop in North-East India.


F-ratio probabilities from binomial tables.


A deficiency in the summation of chi procedure.


A migration model.

A migration model.


Inhibitory effects of thiol compounds on kallikrein and on experimental burns in guinea-pigs.


Passage of intravenously infused atropine into perfused cerebral ventricles and subarachnoid space.


The influence of diet on the acute toxicity of injectable iron preparations in the mouse.


The effect of reserpine on the acetylcholine release of the cerebral cortex of dog under different anaesthetics.


The identification of the impurity responsible for the reported pressor activity of xylocholine.


Actions of prostaglandins E1, E2, and F2-alpha on brain stem neurones.


The action of tertiary and quaternary arecaidine and dihydroarecaidine esters on the guinea pig isolated ileum.


Effects of adrenergic neurone blocking agents on voluntary muscle stimulated at different frequencies.


Observations on the content of kininogen, kallikrein and kininase in lymph from hind limbs of dogs and rabbits.


The effect of scalding on the content of kininogen and kininase in limb lymph.


The in vitro inactivation and formation of plasma kinins by spleen cathepsins.


Effects of nicotine and some nicotine-like compounds injected into the cerebral ventricles of the cat.


The immediate source of noradrenaline released in the heart by acetyl choline.


The action of acetyl choline and other drugs upon the terminal parts of the postganglionic sympathetic fibre.


The effects of ethyl alcohol on the blood vessels of the hand and forearm in man.


The effect of analgesic drugs on the release of acetylcholine from electrically stimulated guinea-pig ileum.


Suppression of a Neurospora td mutant that lacks cross-reacting material.


Some components of the genetic loads in irradiated experimental populations of Drosophila melanogaster.


Evidence for two new systems of blood groups in cattle.


Regular changes in mating type composition in selfing cultures and in mating type potentiality in selfing caryonides of Paramecium aurelia.


The genetic control of two types of esterases in inbred strains of the mouse.


The effect of mating status, sex and genotype on longevity in Drosophila melanogaster.


Intergenic cis-trans position effects in bacteriophage T4.


Age dependence of the locations of x-ray induced somatic crossing over in Drosophila.


Sequential nuclear differentiation in Tetrahymena.


Effect of linkage on homozygosity of a population under mixed selfing and random mating.


Linkage group establishment in Neurospora tetrasperma by interspecific hybridization with N. crassa.


Ethyl methanesulfonate-induced lethals in Drosophila--frequency-dose relations and multiple mosaicism.


The probability of consanguineous marriages.


A proposal for a uniform nomenclature in bacterial genetics.


Internuclear effects on prototroph frequencies of some crosses in Neurospora crassa.


On testing whether one locus can account for the genetic difference in susceptibility between two homozygous lines.


The genetics of sound induced seizure in inbred mice.


The mechanism of in vitro stimulation of lipolysis by adrenaline.


Crystallization of ribonuclease T1.

Crystallization of ribonuclease T1.


On a minor component of proteolytic enzymes contained in the pineapple fruit.


Regulation by illumination of the citric acid cycle activity in Rhodopseudomonas spheroides.


Kinetic studies on gluc-amylase. 3. The influence of pH on the rates of hydrolysis of maltose and panose.


The occurrence of 10-hydroxystearic acid in adipocere.


Effect of deoxygenation of intracellular hemoglobin on red cell glycolysis.


An analysis of contrast effects in multiple schedules. Some phenomena of behavioral contrast in multiple schedules are reviewed, and three accounts of contrast are considered. Rate changes within a constant schedule component (transient contrasts) are distinguished from rate changes across successive schedule cycles (sustained contrasts). Pigeons were exposed to a three-component multiple schedule, in which a stimulus correlated with a constant variable interval schedule of reinforcement was preceded by a stimulus correlated with more frequent variable interval reinforcement, or by an extinction stimulus. If the preceding stimulus was correlated with more frequent reinforcement, the response rate in the constant component was low and increased with time. If the preceding stimulus was correlated with extinction, the rate in the constant component was high and decreased with time. Similar transient contrasts were observed in a two-component multiple schedule with different variable interval schedules in the two components. The transient contrast effects in the three-component schedule were shown to depend on differential reinforcement frequency rather than differential response rate in the preceding component. Such transient contrasts were not sufficient to account for sustained contrast effects observed in these experiments. The relation of these findings to the concepts of excitation and inhibition is discussed.


Concurrent schedules of interresponse time reinforcement: probability of reinforcement and the lower bounds of the reinforced interresponse time intervals. Data were obtained with rats on the effects of interresponse time contingent reinforcement of the lever press response using schedules in which interresponse times falling within either of two temporal intervals could be reinforced. Some of the findings were (a) the mode of the interresponse time distribution generally occurred near the first lower bound when the maximum reinforcement rate for the two lower bounds was equal; this also frequently occurred even when the reinforcement rate was less for the first lower bound; (b) as is the case with schedules using a single interval of reinforced interresponse times the values of the lower bounds partially determined the location and spread of the distributions; but the particular pair of values used did not seem to influence the effects of the probabilities of reinforcement; (c) although the modal interresponse time was usually at the lower bound of one of the two intervals of reinforced interresponse times, no simple relation existed between either the probability or rate of reinforcement of interresponse times in these two intervals and the location of this mode.


Multiple punishment schedule.

Multiple punishment schedule. Concurrent schedules of punishment and fixed-ratio reinforcement were studied in six white Carneaux pigeons. Two stimuli were alternated on the translucent key which served as the response mechanism. The pigeons were exposed to continuous punishment in one stimulus and first response punishment in the other. It was found that continuous punishment suppressed the fixed-ratio performance more than did punishment of the first response. Typically, a ratio run of responses was completed in spite of the onset of continuous punishment. Responding was then reduced for the remainder of the continuous punishment stimulus, except for those times when responding was initiated near the end of the stimulus. The results indicate that a multiple schedule can be used to compare different schedules of punishment in the same organism.


A device for rapid presentation of monochromatic stimuli.


Observing behavior during interval schedules. Experiment 1 showed that the three stimuli associated with three chained fixed-interval links could be used to maintain observing behavior. Experiment 2 showed that three stimuli correlated with the passage of time since the last reinforcement in a fixed-interval schedule could be used to maintain observing behavior. In both experiments most observing responses occurred midway between reinforcements. Few occurred just before or just after reinforcement. Experiment 3 showed that the decline in the rate of observing behavior just before reinforcement was reduced when more stimuli could be observed. The relatively high terminal rate of observing behavior that resulted was maintained even when at least 4 sec intervened between the reinforcement and the last observed stimulus.


A method for automatic programming of spectral stimuli using a monochromator.


Varying temporal placement of an added stimulus in a fixed-interval schedule. One paradigm for exploring stimulus effects on behavior is defined for steady state experiments. The paradigm is illustrated by a 60-sec fixed-interval reinforcement schedule wherein a 6-sec light is introduced into each interval. The temporal relation of this stimulus to the reinforcer is the independent variable that is systematically explored. Two experiments studied this temporal relation under two parametric conditions: (a) when the 6-sec light occurs once in each 60-sec interval, (b) when the 6-sec light occurs twice in each interval, the second time always during the 6 sec immediately preceding the reinforcer. Functions are presented showing the effect of the 6-sec light on responding at all points in the fixed-interval.


An electrophysiological stimulator with digital logic.


The role of discrimination training in the generalization of punishment. Pigeons were trained to respond equally to various orientations of three parallel lines projected on a response key. One group was then punished for responding to the vertical lines, but not punished in a line-absent condition. Two other groups were also punished but had no opportunity to make such a discrimination. Orderly generalization gradients were obtained from the discrimination group during recovery from punishment, with least responding to the vertical lines and higher rates to other orientations. Gradients obtained from the non-discrimination groups were flat. A discrimination of punishment contingencies appears to be necessary for a stimulus correlated with punishment to acquire control over its reductive effects.


Some effects of methylphenidate on stimulus control of ratio avoidance behavior in the rat. After exposure to an avoidance schedule which included a warning signal, a rat was placed on a multiple schedule in which the first component was the same as before, i.e., a single response reset the response-shock interval, delaying shock, and the second component differed only in that four bar-presses were required to postpone shock. A fixed ratio requirement of four responses (FR 4) generated behavior resembling a fixed ratio requirement of one response (FR 1) since responding was controlled by the warning signal but more shocks were received. At a dosage of 2 mg/kg, methylphenidate given intraperitoneally decreased shock frequency during FR 4 periods while FR 1 behavior was not affected; at 4 mg/kg, stimulus control of avoidance responding was impaired during both components. Results at 4 mg/kg were partially confirmed by two animals exposed to an FR 4 avoidance schedule which included a warning signal but with different parameters. Response distributions showed that methylphenidate increased response rates in the absence of the warning signal, i.e., stimulus control of ratio-avoidance behavior was impaired although the increased response rates reduced shock frequency. One hour later responses again occurred more frequently during the signal than in its absence but shocks were less frequent than during control (non-drug) periods.


An inexpensive pulse source for obtaining elapsed time.


Negative reinforcement as shock-frequency reduction. Is a conditioned aversive stimulus necessary in avoidance conditioning? Or is a reduction in the rate of aversive stimulation alone sufficient to generate and maintain an avoidance response? Rats were subjected to an avoidance procedure in which shocks occurred randomly in time, but a response could reduce the overall rate of shock. Fifteen acquisition curves, obtained from 16 animals, showed both immediate and delayed, rapid and gradual increases in response rate; there was no representative acquisition curve. Response rates were directly related to the amount by which the response reduced shock frequency. In extinction, when shock rates were not affected by responding, the response total was inversely related to the amount by which the response had reduced shock frequency during prior conditioning, with as many as 20,000 extinction responses when the shock frequency reduction had been relatively small. Responding on this procedure shows that avoidance conditioning can occur without benefit of either classical exteroceptive stimuli or covert stimuli inferred from the temporal constancies of a procedure. It also shows that reduction in shock rate is alone sufficient to maintain avoidance.


An electro-mechanical flip-flop with applications to counting, timing and randomization.


Avoidance of a return to the first component of a chain from the terminal component. Three pigeons were trained on a chained fixed interval-fixed ratio schedule. Avoidance behavior which postponed a return to the first chain component from the second component was maintained on a second response key concurrently with the second component. When the fixed interval length was increased, avoidance rates first increased and then decreased as a function of fixed interval length. As the fixed ratio requirement was increased for one subject, avoidance rates first declined and then increased at larger fixed ratio values. Avoidance behavior maintained by postponing the first chain component was similar to avoidance behavior maintained by postponing a time out period.


Probabilistically reinforced choice behavior in pigeons. A single principle, "momentary maximizing", may account for much of a pigeon's steady-state behavior in both probability learning and concurrent variable interval experiments. The principle states that a pigeon tends to choose the alternative that momentarily has the higher probability of reinforcement. A successive discrimination procedure, which produced matching in an earlier experiment, produced here a tendency to maximize if training were adequately extended. Maximizing was produced also by other procedures, in which no reinforcing event was presented on some trials: one procedure did and two did not provide a bird with information about the availability of reinforcement on a key after an unreinforced response on the other key. The latter two procedures were analogous to concurrent variable interval schedules in two respects: the reinforcement probability on one key increased while a bird responded on the other key; and they produced matching. But sequential statistics suggested that matching resulted from momentary maximizing. Depending on the procedure, the tendency to maximize produced different relative frequencies of pecking a key for a fixed relative frequency of reinforcement. Computer simulation of maximizing behavior in several concurrent variable interval schedules produced matching and sequential statistics similar to those produced by a real bird.


Stimulus generalization: the ordering and spacing of test stimuli. Twenty-four pigeons learned a successive discrimination between 500 mmu (S+) and 574 mmu (S-). When tested in extinction, some birds received stimuli around S+, with no S- presentations. These birds showed a positive peak shift, with maximum responding not at 550 mmu, but displaced to 538 mmu and 544 mmu. Other birds were tested with stimuli around S-, with no S+ presentations. These birds showed a negative shift, with least responding not at 574 mmu, but at 586 mmu. Though the first group was tested around S+ and the second around S-, total responding between groups did not differ. When retested on the other half of the continuum, however, birds that had gone from the S+ half to the S- half responded fewer times than those that had gone from the S- half to the S+ half. In a second experiment, reducing stimulus spacing from 6 mmu to 2 mmu produced flatter gradients and decreased the amount of positive shift. In a third experiment, birds were tested across the whole continuum with stimuli presented in serial order. A sequence from 538 mmu to 586 mmu produced no responding after the first part of the session; a sequence from 586 mmu to 538 mmu produced responding throughout the session.


Effects of overtraining, irrelevant stimuli, and training task on reversal discrimination learning in children.


Extinction and disinhibition as a function of reinforcement schedule with severely retarded children.


Effects of overtraining and age on intradimensional and extradimensional shifts in children.


Conditioned head-turning in human newborns.


Discrimination of symmetrical and asymmetrical dot patterns by retardates.


Relationship between activity level and delay of reinforcement in the retarded.


Instrumental performance as related to several reward schedules and age.


Studies on the incidence of larval trematodes infecting the fresh water molluscs of Llangorse Lake, South Wales.


On the comparative susceptibility of Lymnaea natalensis (Kraus) and L. rufescens (Gray) to infection with Fasciola gigantica (West African strain) and the tissue responses in the snails.


On a parasitic nematode, Galebiella sp. Basir, 1941, from aquatic beetles in Egypt.


On the morphology of Schistosoma rodhaini from Kenya.


Penetration by the miracidia of S. mansoni into the snail host.


On the life history, growth and development from the metacercarial stage to adulthood, of Clinostomum tilapiae Ukoli, 1966.


On some larval trematodes from Lymnaea peregra (Muller) in Scotland.


The intermediate host and the cercaria of Gastrodiscoides hominis (Trematoda: Gastrodiscidae). Preliminary report.


Studies on larval trematodes infecting the freshwater molluscs of Llangorse Lake, South Wales. 3. The furcocercariae.


A model for information processing with reference to vision.


T-m-limited renal tubular reabsorption and the genetics of renal glucosuria.


A model for the penetration of integuments by nonelectrolytes.


Introduction to steroid molecular stacking.


A continuous-time model in population genetics.


Inverse problems in ecology.

Inverse problems in ecology.


Segmental differential approximation and biological systems: an analysis of a metabolic process.


A comment on the binding of quaternary ammonium inhibitors at the anionic site of acetylcholinesterase.


The site distribution parameter for radiation induced chromosome exchanges.


Receptive fields and the two-point threshold.


On the propagation of the nervous impulse down medullated and unmedullated fibers.


Allocation of errors to theory and experiment.


The advantages of hermaphroditism and parthenogenesis.


A model illustrating possible instability of cellular structure under conditions of weightlessness.


A characteristic of self-regulated linear energy converters. The Hill force-velocity relation for muscle.


A model of crossing-over based on alternately-oriented dipoles.


Formal connections of community leadership to the health system.


Methods of planning health services in Czechoslovakia.


Vital and health statistics of the future.


Sociomedical approaches to community health programs.


Effect of DDT on the urinary excretion of epinephrine and norepinephrine by rats.


Metabolism of 2-ethylhexyl sulfate by the rat and rabbit.


Toxicologic and pharmacologic properties of tolnaftate, an antitrichophyton agent.


Teratogenesis study of tolnaftate, an antitrichophyton agent.


Subacute toxicity of cephaloridine to various species.


Activated charcoal vs. "universal antidote" as an antidote for poisons.


Stimulatory effect of nicotine on the metabolism of meprobamate.


Resistance to pentobarbital in rats fed a cachexigenic diet.


Dose-time effect of isoproterenol on aspartate amino-transferase and necrosis of the rat heart.


Toxicologic studies on monochloroacetaldehyde 2,4-dinitrophenylhydrazone, a foliar fungicide.


Aryl esters and stimulus frequency as interdependent modulators of responses mediated at cholinergic receptors.


Insecticide interactions affecting residue accumulation in animal tissues.


Effect of three derivatives of glutaramide on the epiphyseal cartilaginous disc of mice.


Reversal of a soman-induced effect on neuromuscular function without reactivation of cholinesterase.


Aging and reversal of soman-induced effects on neuromuscular function with oximes in the presence of dimethyl sulfoxide.


Foot deformity in ducks from injection of EPN during embryogenesis.


Reconsideration of the central nervous system pharmacology of amphetamine. I. Toxicity in grouped and isolated mice.


Effect of thiazides on the thyroid gland of rats.


Studies of heat-inducible lambda mutants. II. Production of C-1 product by superinfecting lambda+ in heat-inducible lysogens.


Which of an aphid's stylets carry transmissible virus?


Electron microscopy of pea enation mosaic virus in plants and aphid vectors.


Oxidative inactivation of Tulare apple mosaic virus.


A cold-sensitive mutant of bacteriophage T1.


Virions associated with progressive multifocal leukoencephalopathy.


Experience with the surgical treatment of vasorenal hypertension.


The distribution of anterior cervical hair in white and Negro males.


Nutrition in physical anthropology.

Nutrition in physical anthropology.


A dermatoglyphical study of metacarpophalangeal creases.


Effects of various anions and cations on the release of four dehydrogenases from brain mitochondria by a non-ionic detergent.


Alkylation of cytochromes c. II. Carboxymethylation of beef and human cytochromes c in the oxidized and reduced forms.


On the activation of glucose oxidation by iodoacetate in ascites tumor cells.


Regulation of nitrate reductase in cultured tobacco cells.


Inhibition of histamine methyltransferase by serotonin and chlorpromazine derivatives: electronic aspects.


The non-identity of yeast nicotinic acid mononucleotide pyrophosphorylase and nicotinic acid mononucleotidase.


Inhibition of tyrosine aminotransferase activity by low concentrations of urea.


The purification and properties of a particulate renal dipeptidase.


Diaminopimelate decarboxylase of Lemna perpusilla: partial purification and some properties.


Purification and characterization of nitrite reductase from Achromobacter fischeri.


The structure of transient hydroperoxides in the autoxidation of reduced flavins.


Hydrolysis of the A and B chains of oxidized insulin by thyroid acid proteinase.


Use of casein in assays for proteolytic activity in tissue extracts: a warning.


Hormonal effects on purine synthesis in dog thyroid.


The preparation of 32P-labelled nucleoside 5'-monophosphates.


Polynucleotide analogues. VIII. Poly 3-isoadenylic acid.


Thymidine kinase and thymidylate kinase in the silkworm, Antheraea pernyi.


Genetic recombination of bacteriophage phi-X-174 in spheroplasts.


Structure of the replicative form of bacteriophage phi-X-174. Physico-chemical studies.


Synthesis of double-stranded viral RNA by cell-free extracts from turnip yellow mosaic virus-infected leaves.


The preparation of rat-liver soluble ribonucleic acid.


An RNA fraction in human placenta with template activity.


Prevention by high concentrations of cytidine of inhibition by thymidine of DNA synthesis in rat-thymus cells.


Action of daunomycin on nucleic acid metabolism in HeLa cells.


Utilisation of certain derivatives of alanine and arginine by yeasts.


The genetic coding of protein structure.


A gentle method for isolation of DNA and histones from the same small tissue sample.


Absence of increased [14C]orotic acid uptake in perfused liver remnants.


Net DNA synthesis in anucleate fragments of Acetabularia mediterranea.


Circular mitochondrial DNA.

Circular mitochondrial DNA.


A spectrofluorometric method for the study of transcription of single-stranded DNA by RNA polymerase.


Basic proteins from pig renal cortex.

Basic proteins from pig renal cortex.


Morphological indices of the blood of Microtus nivalis (Martins, 1842) (Mammalia, Microtidae).


Influence of time of exposure to light on the activity of the antibacterial substance in Chlorella vulgaris.


Physical performance and maximum oxygen uptake in man in exercise dehydration.


Allogeneic grafts of rabbit dental pulp.


Lytic enzymes in the digestive juice of Helix pomatia; chitinases and muramidases.


The identification of dimethyl-beta-propiothetin in the algae syracosphaera Carterae and Ulva lactuca.


Postnatal changes in beta-galactosidase activity in the jejunum and ileum of mice, rabbits, and guinea pigs.


Tissue lactic dehydrogenase isozymes. Developmental patterns in the neonatal rat.


Effects of starch concentration on the resolution of serum proteins by gel electrophoresis; a six-species comparison.


The isolation and characterization of an acid-soluble protein from myelin.


The role of a protease in sporulation of Penicillium janthinellum.


Proteolytic enzymes in normal and dystrophic mouse muscle.


The stabilization of hepatic glycogen synthetase at 37 degrees C by glucose-6-phosphate and anaerobiosis.


The influence of cocaine on the metabolism of adrenaline in vivo and on the storage and release of catecholamines in isolated chromaffin granules.


Metabolism of vanillin and related substances in the rat.


Differences in the glucose metabolism and insulin responsiveness of rat and human adipose tissue.


Chemical and enzymatic determinations of available lysine in raw and heated navy beans (Phaseolus vulgaris).


On the in vitro development of pseudo-tryptophan synthase activity by extracts of Neurospora crassa mutant strains td6 and td120.


Chlorpromazine and fur shaking in mice.

Chlorpromazine and fur shaking in mice.


Folic acid and biotin on the metabolism of 1 carbon unit: utilization of beta-carbon of serine for the synthesis of methionine.


ATP-dependent Ca++-extrusion from human red cells.


Protective action of substrate from heat inactivation of taka-amylase A.


Inhibition of skin calcification (calciphylaxis) by polyphosphates.


Role of heavy water as solvent in the antigen-antibody precipitin reaction.


On the digestive enzymes and the cytology of midgut of Leogryllus bimaculatus Sauss.


Localization of the exogenous fluorescent histones in Ehrlich ascites tumour cells.


The distribution of billirubin in rat liver fractions.


Carcinogenesis and regeneration in newts.


Action of cortisone on human fibroblasts in vitro.


A descending pathway with monosynaptic action on flexor motoneurones.


Inhibition of aggregation of heat-denatured Taka-amylase A by substrate.


Intracellular recording of electrical response of muscle fiber to transversely applied middle-frequency pulse stimulation.


Interaction patterns of preoptic and olfactory bulb evoked responses in the rat.


Absence of electrical activity of the pigeon's pineal organ in response to light.


On the incorporation of uridylate into cerebral cortex ribonucleic acid.


Surface microscopy of the large bowel.

Surface microscopy of the large bowel.


Pharmacological properties of neurons of the paramedian reticular nucleus.


Isolation of homogentisic acid from urine of alcaptonuric cases by means of an anion-exchanger.


Production of ergotamine by a strain of Claviceps purpurea (Fr.) Tul.


Plutonium-237 labelling: a new technique for plutonium metabolic studies in animals.


Uterine metabolic status during pregnancy and litter size in rats.


Pituitary potency and ovarian activity in rats on two levels of dietary energy.


The use of animal proteins for food.

The use of animal proteins for food.


Chemical and biochemical production of food for man and animal.


Erythrocyte replacement at metamorphosis in the frog, Rana pipiens.


Neurosecretory cells in the central nervous system of the adult blowfly, Phormia regina Meigen (Diptera: Calliphoridae).


The gastric argentaffin cell population of the rat.


A study of a hereditary cataract in the mouse.


The Megachiroptera and Vespertilionoidea of the Microchiroptera.


Microanatomy of the heart and associated structures of two scorpions, Centruroides sculpturatus Ewing and Uroctonus mordax Thorell.


Chemoreceptor sensillum structure in Limulus.


Some cytologic characteristics of the hemocytes of Limulus during clotting.


The development of the osteocranium of Pleurodeles waltlii Michahelles.


The development of the musculature of the hindlimb in the frog, Rana pipiens.


Tooth replacement in the frog Rana temporaria.


Segmental musculature and locomotion in Hermodice carunculata (polychaeta: Amphinomidae).


Excretion of nortriptyline hydrochloride in man. I. Detection and determination of urinary nortriptyline.


Plasma inflammation units: an objective method for investigating effects of drugs on experimental inflammation.


Changes in the concentration of free amino acids in the rat brain during postnatal development.


Cardiac response time of X-15 pilots: a cross-correlation analysis.


Omni-sonic flight and the selection of importantly related man-machine-environment parameters.


Autobioregulation, and the law of homeostatic acceleration.


Design of a versatile hyperbaric chamber assembly for the study of small animals and cell cultures.


The potentiating effects of hyperbaric oxygen and actinomycin d on the irradiation of Ehrlich ascites tumor cells in vivo.


Microsomal hydroxylation of ethylbenzene. Stereospecificity and the effect of phenobarbital induction.


The influence of monoamine oxidase inhibition on catecholamine synthesis.


Bacterial carotenoids. XIX. The carotenoids of Mycobacterium phlei strain Vera. 1. The structures of the minor carotenoids.


Carotenoids and related compounds. 13. Synthesis of 4-keto-gamma-carotene and its 1'-hydroxy-1',2'-dihydro derivative.


The crystal structure of the B-form of fatty acids.


A crystallographic study of N-methyl-pyridine-2-aldoxime (2-PAM) halides.


Identification of bile acids and neutral sterols in guinea pig bile. Bile acids and steroids 163.


Induced heterogeneity of lactoperoxidase.


A peptidase (aminopeptidase B) from cat and guinea pig liver selective for N-terminal arginine and lysine residues. I. Purification and substrate specificity.


Crystalline cytochrome c peroxidase.

Crystalline cytochrome c peroxidase.


Enzymatic determination of anomers of glucose released by glucosidases.


The peroxidase-catalyzed oxidation of thyroxine.


A neutral trypsin-like protease from the rat submandibular gland.


The occurrence of amino acid naphthylamidase in baker's yeast.


Grading of osteoporosis on biopsy specimens.


A rapid method for producing serial undecalcified section of bones.


Juvenile lumbar disc herniations.

Juvenile lumbar disc herniations.


Vertebral column and os calcis fracture patterns in a confined community (Singapore). Notes on fracture incidences as clinical evidence of disturbed bone metabolism with increasing age.


Hyperalgesia of the lumbar nerve roots in sciatica.


Treatment of hip flexion contracture in cerebral palsy patients.


Results of peripheral arterial surgery.

Results of peripheral arterial surgery.


The chewing apparatus. An electromyographic study of the action of the muscles of mastication and its correlation to facial morphology.


Rheumatoid arthritis with chorea. A case report.


A critical evaluation of Nørgaard's technique for early roentgenological diagnosis of rheumatoid arthritis.


The dynamics of the disease process in cases of juvenile rheumatoid arthritis when a surgical treatment is applied.


The effects of microwave radiation on the cellular elements in the peritoneal fluid and peripheral blood of the rat.


Prolonged effect from intramuscular corticosteroids. Triamcinolone acetonide in rheumatoid arthritis.


Uptake of Se75 in tissues of sheep after administration of a single dose of Se75-sodium selenite, Se75-selenomethionine, or Se75-selenocystine.


Toxicological studies of phenoxyacetic herbicides in animals.


Retrospect and prospect.

Retrospect and prospect.


The evaluation of physical tasks in industry.


Notes on the modification and use of a cascade impactor for sampling in ducts.


The measurement of leakage of respirators.


A sampling anomaly in the determination of atmospheric sulfate concentration.


Air flow induced in enclosed inclined chutes of material handling systems.


Determination of bismuth and tellurium in tissues by atomic absorption spectrophotometry.


Comparison of field methods for estimating carbon monoxide hemoglobin percentages.


Inhalation studies on chloropentafluoroethane.


Gel electrophoresis in the study of pneumoconioses.


Measurement of the performance of film badge services.


Detection of 1,1-dimethylhydrazine by frustrated multiple internal reflection spectroscopy.


A portable monitor for the estimation of tritium in aqueous samples.


On hazards of cancer from ultraviolet light.


Mucosal cellular populations and distribution in the normal canine stomach.


Ultrastructure of the thymic reticulum in guinea pig. Cytological aspects of the problem of the thymic secretion.


The effect of a muscle relaxant on the growth and differentiation of skeletal muscles in the chick embryo.


Mercury and its inorganic compounds.

Mercury and its inorganic compounds.


Ultrastructural and cytochemical changes in spermatogonia and Sertoli cells of whole-body irradiated mice.


Connections between the T system and sarcoplasmic reticulum.


A fluorescence and electron microscopic study on central monoamine nerve cells.


Guide for training of industrial audiometric technicians.


Sex-ratio data analysed independently of family limitation.


Inheritance of total number of triradii on fingers, palms and soles.


A hitherto undescribed chromosome structural anomaly in a mentally retarded child.


Effect of parity on optimal and critical birth weights.


Birth weight and survival: a hospital survey repeated after 15 years.


Note on dermatoglyphic data in a brachydactylous family.


Hereditary brachydactyly.

Hereditary brachydactyly.


A new type of human haptoglobin Hp 2-1D.


Familial transmission of a translocation between two non-homologous large acrocentric chromosomes. Clinical, cytogenetic and autoradiographic studies.


Further data on the incidence and genetics of the serum cholinesterase phenotype C5+.


Studies on the mechanism of vitamin-like activity of coenzyme Q.


Methane biosynthesis by Methanosarcina barkeri. Properties of the soluble enzyme system.


The relationship of the Hill reaction to photosynthesis: studies with fluoride-poisoned blue-green algae.


Enzymic methods for the microdetermination of glycogen and amylopectin, and their unit-chain lengths.


The formation of branched glucans in sweet corn.


Biochemical correlates of respiratory deficiency. VII. Glucose repression.


The enzymic activity of trypsin autolysis products.


The subunit polypeptides of human fibrinogen.


Ionic effects on self-reactivation of p-hydroxymercuribenzoate-inhibited lactate dehydrogenase.


Inhibition of lysozyme by imidazole and indole derivatives.


Glucogenesis from sorbitol U-14C in liver slices of starved rats.


Interaction of amyloplasts with enzymes. I. Phosphorylase adsorption on amyloplasts in Vicia faba.


Biosynthesis of bacterial glycogen. V. The activation and inhibition of the adenosine diphosphate glucose pyrophosphorylase of Arthrobacter viscosus NRRL BI973.


Uridine diphosphate glucose and the synthesis of phenolic glucosides by mollusks.


Glycosylation of serine residues by a uridine diphosphate-xylose: protein xylosyltransferase from mouse mastocytoma.


Factors affecting the activity of muscle glycogen synthetase. 3. The reaction with adenosine triphosphate Mg++, and cyclic 3'5'-adenosine monophosphate.


Observations on the de Novo synthesis of fructosans in vivo.


Properties of a polygalacturonic acid-synthesizing enzyme system from Phaseolus aureus seedlings.


In vivo and in vitro complementation between aspartic transcarbamylase mutants of neurospora.


Relationship between nutritional status and fatty acid synthesis by microsomal and soluble enzymes of pigeon liver.


The biosynthesis of chondroitin sulfate.


Effect of changes in the outer structure of glycogen on the debranching activity of the transferase-glucosidase system.


Biosynthesis of the peptidoglycan of bacterial cell walls. I. Utilization of uridine diphosphate acetylmuramyl pentapeptide and uridine diphosphate acetylglucosamine for peptidoglycan synthesis by particulate enzymes from Staphylococcus aureus and Micrococcus lysodeikticus.


Purification and properties of oxalic acid oxidase.


Enzymic binding of sialyl groups to ganglioside derivatives by preparations from the brain of young rat.


Formation of oligosaccharides in liver.

Formation of oligosaccharides in liver.


Glycogen metabolism in muscle homogenates. I. The effect of potassium ions on glycogen synthesis.


Synthesis and interrelatonship of ubiquinone and ubichromenol in rat tissues.


Protein conformation: autoplastic and alloplastic effects.


Growth of Thiobacillus thiooxidans on glucose.


Studies on the biosynthesis of starch. I. Isolation and properties of the soluble adenosine diphosphate glucose: starch glucosyltransferase of Solanum tuberosum.


The reaction of guanine derivatives with 1,2-dicarbonyl compounds.


The structure of the Aerobacter aerogenes A3(S1) polysaccharide. II. Sequence analysis and hydrolysis studies.


Studies on dextran and dextran derivatives. X. The interaction of dextran sulfate with lysozyme.


The preparation and properties of human fibrinogen of relatively high solubility.


Studies on verdohemochrome.

Studies on verdohemochrome.


Interactive potentialities between thalamic relay-nuclei through subcortical commissural pathways.


Studies on the biosynthesis of the erythromycins. I. Isolation and structure of an intermediate glycoside, 3-alpha-L-mycarosylerythronolide B.


The chemistry of tyrocidine. VII. Studies on association behavior and implications regarding conformation.


Studies on amino acid substitution in the biosynthesis of the antibiotic polypeptide tyrocidine.


Purification and some properties of mouse brain L-glutamic decarboxylase.


Direct and 18-O-exchange measurements relevant to possible activated or phosphorylated states of myosin.


A hydrocarbon-water model for the formation of the enzyme-inhibitor complex in the case of alpha-chymotrypsin.


Inhibition of glutamic dehydrogenase by pyridoxal 5'-phosphate.


Glutamic-aspartic transaminase. XI. Reactivity toward thiosemicarbazide.


Circular dichroism and optical rotatory dispersion of glycogen phosphorylase.


The kinetic equivalence of reactivated phenylmethanesulfonyl-alpha-chymotrypsin and native alpha-chymotrypsin. A reexamination.


Formation of nonreactivatible isopropylmethylphosphonofluoridate-inhibited acetylcholinesterase.


The effect of metal ions on labile phosphates. I. The hydrolysis of acetyl phosphate dianion.


The preparation and properties of the isolated alpha and beta subunits of hemoglobin A.


Microsomal oxidases. II. Properties of a pork liver microsomal N-oxide dealkylase.


The reactions of amines and amino acids with maleimides. Structure of the reaction products deduced from infrared and nuclear magnetic resonance spectroscopy.


Sedimentation equilibrium in reacting systems. IV. Verification of the theory.


Ultracentrifuge investigation of protein aggregation in dilute solutions of C-phycocyanin.


Initial attempts at a theoretical calculation of the conformation of gramicidin-S.


Optical rotatory dispersion studies of yeast alanine and tyrosine transfer ribonucleic acids. Evidence for intramolecular hydrogen bonding and discussion of conformational aspects.


Source of urinary 8-hydroxy-7-methylguanine in man.


Studies on the nucleotide arrangement in deoxyribonucleic acids. XI. Selective removal of cytosine as a tool for the study of the nucleotide arrangement in deoxyribonucleic acid.


Chemical studies on amino acid acceptor ribonucleic acids. VII. Partial ribonuclease digestion of alanine and valine soluble ribonucleic acid from yeast.


Topography of nucleic acid helices in solutions. I. The nonidentity of polyadenylic-polyuridylic and polyinosinic-polycytidylic acid helices.


The synthesis and properties of substituted 6-hydroxylaminopurines.


The synthesis of O-serine glycosides.

The synthesis of O-serine glycosides.


On the neoplastic transformation induced by vaccinia virus in primary cultures of mouse embryos.


Synthesis of nucleic acids in normal cells of Mycobacterium sp. 607 and in cells infected with Mycophage D 29.


Induction of the chloramphenicol nitrogroup reducing activity in animals.


Quantitative determination of PTH amino acids in thin-layer chromatograms.


Influence of temperature on the composition of fatty acids in frog tissues.


Further observations on transformation in streptococci. Competence factor in Streptococcus challis.


The nucleus of the facial nerve; the relation between cellular groups and peripheral branches of the nerve.


Effect of cobalt on guinea pig kidney.

Effect of cobalt on guinea pig kidney.


Neural mechanisms involved in the critical flicker frequency of the cat.


Electrical stimulation and lesions of the hypothalamus in alloxan diabetic rabbits.


Biogenic amines in various brain regions of growing cats.


Effect of adrenergic beta-receptor blocker on epinephrine-induced cardiac arrhythmias during halothane anaesthesia.


Nylidrin HCl: a beta-sympathetic stimulant in the management of haemorrhagic shock.


Neuroleptanalgesia with fentanyl-droperidol: an appreciation based on more than 1000 anaesthetics for major surgery.


A report on clinical uses of droperidol and fentanyl.


Effects of halothane on life expectancy of mice.


Fluid therapy during paediatric surgery.


Experience with a portable peripheral nerve stimulator.


Acute massive collapse of the lungs: a case report.


A biochemical abnormality in schizophrenia involving ascorbic acid.


Investigation of temporal lobe electrical activity during insulin hypoglycemia.


Gastrointestinal pain and electroencephalographic abnormality in adults.


The in vivo detection of some oxidation products of adrenalin and noradrenalin (coming from adrenochrome and noradrenochrome) by fluorimetric spectrophotometric and paper chromatographic analysis.


The effects of psychedelic (LSD) therapy on values, personality, and behavior.


The origin, course and termination of corticospinal fibers in the slow loris, Nycticebus coucang (boddaert).


Autoradiographic distribution studies in mice with C14-imipramine.


Somatic sensory representation in the thalamic ventrobasal complex of the Virginia opossum.


Temporal relationship between myelinogenesis and the appearance of a basic protein in the spinal cord of the white rat.


The projection of optic fibers to the visual centers in the cat.


Sprouting of optic tract projections in the brain stem of the rat.


Evoked potential study of connections of avian archistriatum and caudal neostriatum.


Lymphangiographic study of the normal lymphatic system of the lower limb and its surgical application.


Skin glucose tests for screening diabetes mellitus.


Recurrent vascular ulcers of leg.

Recurrent vascular ulcers of leg.


The allergens of asthma in children in the United Arab Republic.


Clinical observations on enteric fever in Iraq.


Evaluation of spermatozoal density in male fertility.


The recent conceptions of traumatic perforations of the tympanic membrane with a record of twenty cases.


Some observations on the endotoxin of the cholera vibrio.


Physiological approach to industrial pulmonary diseases.


Causes and prevention of deafness in Egyptian children at school age.


Self-evaluation in young children.

Self-evaluation in young children.


The effects of food deprivation on unreinforced and light-reinforced bar pressing.


Effects of mother's shock traumatization in infancy upon offspring behavior.


Spontaneous hand positions of newborn infants.


Activity and exploration as a function of age and deprivation.


Some effects on operant conditioning of ionizing radiation to the whole-head.


Verbal conditioning of common-word and uncommon-word associations in retardates and normals.


Subject emotionality and susceptibility to environmental stress.


Hand preference and developmental status of infants.


Perception of quantity.

Perception of quantity.


The effect of instruction and performance set on color-form perception in young children.


The ultrastructural localization of cholinesterase activity in the sciatic nerve of the rat.


Quantitative analysis of the esterases in rat megakaryocytes by a radio-isotope cytochemical technique.


Histochemical detection of triglyceride esters with specific lipases and a calcium-lead sulphide technique.


The development of lysosomes in rat skeletal muscle in trichinous myositis.


The enzymatic hydrolysis of amino acid beta-naphthylamides. II. Partial purification and properties of a particle-bound cobalt-activated rat kidney aminopeptidase.


Resolving power, sensitivity and latent image fading of soluble-compound autoradiographs.


The somatic chromosomes of the ferret.

The somatic chromosomes of the ferret.


A direct lead method for the electron microscopic visualization of alkaline phosphatase activity.


Nonspecific deposition of lead in experiments on fine structural localization of enzymatic activity of rat blood platelets.


Histophenotype of the antennaless mutation in Drosophila melanogaster.


Influence of anabolic hormones on phenylalanine metabolism. I. Studies on chronic phenylketonuric patients.


Influence of anabolic hormones on phenylalanine metabolism. II. Studies in animals.


Parietal lobe dysfunction in subnormal patients.


The Cri du Chat syndrome.

The Cri du Chat syndrome.


Prognosis in psychotic children: report of a follow-up study.


Ascorbic acid nutrition in mentally subnormal patients.


An approach to the study of dreaming and changes in psychopathological states.


Dreaming sleep (the D-state) and the menstrual cycle.


Some aspects of mother-child relationship pertaining to infantile separation anxiety.


Pupillary response to light as an indicator of functional psychoses: a failure to replicate.


Association of a quantitative cytochemical variable, Barr body score, with length of confinement in state mental hospitals.


Effect of thyroxine on the deposition of phospholipids in the brain in vivo and on the synthesis of phospholipids by brain slices.


Changes with age in the utilization of glucose carbon in liver and brain.


On subcellular localization and binding of choline acetyltransferase in the cholinergic nerve endings of the brain.


On the question of the localization of choline acetyltransferase in synaptic vesicles.


Electrical activities in thin sections from the mammalian brain maintained in chemically-defined media in vitro.


Mammalian brain acetylcholinesterase. Purification and properties.


Mammalian brain acetylcholinesterase. Effects of surface active agents.


Neuroglial localization of potassium and sodium effects on respiration in brain.


Utilization of [U-14C]glucose in brain after total hepatectomy in the rat.


Influence of sucrose on the extraction of proteolipids from brain and other tissues.


Substrate changes in peripheral nerve recovering from anoxia.


Studies on free amino acid metabolism in excised cervical sympathetic ganglia from the rat.


Studies on the acid-extractable proteins of bovine brain white matter.


Determination of gamma-aminobutyric acid and other free amino acids in whole brains of rats poisoned with beta, beta'-iminodipropionitrile and alpha, gamma-diaminobutyric acid with, or without, administration of thyroxine.


Serotonin binding to nerve ending particles and other preparations from rat brain.


The action of organic solvents on the myelin sheath of peripheral nerve tissue. I. Methanol, ethanol, chloroform and chloroform-methanol (2:1, v-v).


The action of organic solvents on the myelin sheath of peripheral nerve tissue. 3. Chlorinated hydrocarbons.


The action of organic solvents on the myelin sheath of peripheral nerve tissue. II. Short-chain aliphatic alcohols.


Neurochemical-electrographic relationships after cortical applications of strychnine, eserine and nembutal.


The distribution and rates of formation of catecholamines in several regions of bovine brain.


Brain acetylcholine studies: a new extraction procedure.


Quantitative observations upon acetylcholine hydrolase activity of nerve cells after axotomy.


Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania.


Solubilization and partial purification of particulate guanine deaminase from rat brain.


Biochemistry of sphingolipids. Paper chromatography of ceramide glucosides and ceramide galactosides.


Turnover time of prothrombin and of prothrombin messenger RNA and evidence for a ribosomal site of action of vitamin K in prothrombin synthesis.


Teratological studies in the thalidomide field.


The woolly opossum--a new research tool for cytogenetic studies.


Correlation of clinical and angiographic findings in one hundred patients with 'completed stroke'.


Glycolytic and oxidative metabolism of isolated prepuberal rat ovaries of androgenized rats.


Senile hypophyseal syndromes.

Senile hypophyseal syndromes.


Short and long term memory in two inbred strains of mice.


Aphasic disorders and verbal hallucinations.


The isolation of catecholamine storage granules from adrenal medulla by the membrane filter technique.


In vitro lipogenesis in adipose tissue of fed and fasted rats: mechanism of pyruvate stimulation.


Familial multiple sclerosis in Poland. 1. Geographical distribution of the disease.


Selective release of noradrenaline and adrenaline from isolated adrenal medullary granules.


Alterations of the calcium accumulating ability of striated muscle following denervation.


Effect of castration on the oxygen uptake of different parts of hypothalamus.


Microelectrode determination of the intracellular chloride concentration in nerve cells.


"Applejack" concentration of urinary chlorpromazine metabolites: a widely applicable and mild procedure.


Metabolic effects of epinephrine in the perfused rat heart. I. Comparison of intracellular redox states, tissue pO2 and force of contraction.


Metabolic effects of epinephrine in the perfused rat heart. II. Control steps of glucose and glycogen metabolism.


Early changes in liver cytoplasmic RNA of hydrocortisone-treated rats.


Inhibition of the biosynthesis of thymidylic acid by 4-N-Hydroxy-2'-deoxycytidine in L5178Y leukemic cells.


Curare sensitivity in neonatally thymectomized mice.


Production of graft-versus-host disease in the rat and its treatment with cytotoxic agents.


Estimation of zinc-65 background levels for marine coastal waters.


Effects of x-irradiation on the metabolic changes accompanying phagocytosis.


Aggregation of guinea-pig platelets by adenosine diphosphate.


Aggregation of rabbit and guinea-pig platelets by oxime esters.


Possible mechanism of aggregation of blood platelets by adenosine diphosphate.


Autoradiographic demonstration of cholesterol filtration and accumulation in atheromatous rabbit aorta.


Growth and food consumption of labyrinthectomized hamsters during chronic centrifugation at 5g and 6g.


Long-term culture of embryonic cells of Drosophila melanogaster.


Antigenic properties of soluble elastins and their use in detecting soluble elastin in ligament extracts.


Excretion of xanthurenic acid in the urine of women taking progestogen-oestrogen preparations.


Amino-acid composition of the acquired pellicle of human tooth enamel.


Dehydrogenase isoenzymes from legume root nodules.


Reversible action of pullulanase.

Reversible action of pullulanase.


Influence of cortisone on the substrate-induction of enzymes in rat liver.


Depolarization of central terminals of group Ia muscle afferent fibres during desynchronized sleep.


Lipotropic effect of cold on rat liver.

Lipotropic effect of cold on rat liver.


A functional caudal photoreceptor in blind cavernicolous crayfish.


Pyrogens and monoamine oxidase inhibitors.


Testing chemicals for mutagenicity in a mammal.


Reactivation of paraoxon-inactivated cholinesterase in the rat cerebral cortex by pralidoxime chloride.


Effect of environmental temperature on the metabolic response to injury.


Role of the lens in the morphogenesis of the iris and cornea.


Strontium-90 content of first bicuspids.


Use of multiple biopsies for the study of the cell cycle of the mouse hair follicle.


Unexpected dose-rate effect in the killing of mice by radiation.


New method for studying mammalian melanocytes in vivo.


Transduction in Proteus morganii.

Transduction in Proteus morganii.


Genetic control of lipid metabolism in Tribolium.


Cusp number, occlusal groove pattern and human taxonomy.


Prenatal loss of foetuses and abortion in guinea-pigs.


Research computers.

Research computers.


Effects of loudness and presentation-rate on auditory short-term memory.


Computers for British research.

Computers for British research.


An operator model of crossing-over.

An operator model of crossing-over.


Hyperploidy effect of lymphocyte extract on fibroblasts in vitro.


Deoxyribonucleic acid content of mitotic nuclei of two mouse tumours.


Deoxyribonucleic acid synthesis time of erythropoietic and granulopoietic cells in human beings.


Chemical treatments of staphylococcal infections in mice.


Inhibitory action of the testosterone and liver extract on staphylococcal infections in mice.


Determination of trace amounts of cobalt in sea-water after enrichment with solid manganese dioxide.


Food from coal-derived materials by microbial synthesis.


Chemical synthesis of the tryptophan path intermediate 1-(o-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.


Identification of the yellow lupin growth inhibitor as (+)-abscisin II ((+)-dormin).


Enzymatic degradation of L-cystine by cytoplasmic particles from cabbage leaves.


A simple bioassay for gibberellic acid.

A simple bioassay for gibberellic acid.


Purification of insulin labelled with iodine-131.


Paralytic shellfish poison: serological assay by passive haemagglutination and bentonite flocculations.


Use of liquid ion exchange chromatography for the separation of organic compounds.


Cholinergic mechanism of depressor response to small doses of adrenaline.


Modification of the auditory flutter fusion threshold by centrally acting drugs in man.


Arylacethydroxamic acids: a new class of potent non-steroid anti-inflammatory and analgesic substances.


Athletic performance at high altitude.

Athletic performance at high altitude.


Tolerance of chickens to thiabendazole.

Tolerance of chickens to thiabendazole.


Effect of removing the neocortex on the response to repeated sensory stimulation of neurones in the mid-brain.


Effect of urgocyton on capillary permeability in rabbits.


Uncoupling of auxin-induced protein synthesis and water uptake by kinetin.


Chromosome number of a sub-antarctic Rubus.


Phosphatidyl carnitine: a possible intermediate in the biosynthesis of phosphatidyl beta-methylcholine in Phormia regina (Meigen).


Inhibitory effects of other antibiotics on bacterial morphologic changes induced by penicillin G.


Level of vitamin B12 in propionate-grown Prototheca zopfii.


Large-scale crystallization of purified human foetal oxyhaemoglobin from cord blood.


Cellular localization of carbon-14 endotoxin in cultured leucocytes.


Fine structure of experimentally produced subsynovial carbon granuloma.


Method for the display of avian chromosomes.


Assessment of body content of radioactive strontium following contamination in adult men.


Prevention of nuclear damage in irradiated rat thymocytes by post-irradiation oxygen deprivation.


Strontium-90 in beagle hair.

Strontium-90 in beagle hair.


A study of the space requirements of wheelchair users.


Self-exercising device for prevention and treatment of drop foot.


Rorschach responses of paraplegic and quadriplegic patients.


Pathological principles in the management of spinal cord trauma.


Fatty acid interconversion by laying hens.


Antigenicity of beta-propiolactone inactivated Newcastle disease virus vaccines prepared from various strains.


Enhancement of sulfaquinoxaline activity by nystatin.


Hypothalamic lesions, growth and body composition of male chickens.


Studies of the chick edema disease. 4. Age sensitivity, recovery and mortality.


Normal levels of selected enzymes in the brain of Coturnix.


Some impression on the integration of medical services in industry.


Recent trends in Great Britain in the field of occupational health.


The medical aspects of accident prevention and rescue.


Rehabilitation.

Rehabilitation.


Some negative thoughts on the future of medicine. Valedictory address.


Medical photography.

Medical photography.


"Breaking the ice".

"Breaking the ice".


Oxygen affinity of chicken blood before and after hatching.


The diffusion coefficient of haemoglobin.


The respiratory gas values of the fetal and maternal blood in Cartesian nomograms.


The sequence of lobar emptying in man.

The sequence of lobar emptying in man.


The Hering-Breuer inflation reflex in man: studies of unilateral lung inflation and vagus nerve block.


Measurement of blood gases by gas chromatography.


Summer accidents claim 27,000 lives.

Summer accidents claim 27,000 lives.


Surface carcinomas of the stomach: pathological features and clinical significance.


Hospitalization of Metropolitan personnel in 1965.


Polyester sheeting (Melinex O), a tissue-culture support easily separable from epoxy resins after flat-face embedding.


Tuberculosis: still a serious problem.

Tuberculosis: still a serious problem.


The relationship of isotope concentration and tumor size to detectability by brain scanning with radiomercury.


Clinical and bacteriological events in experimental lethal pneumococcal infection.


Cellular evolution in induced inflammation in uremic patients.


The effect of penicillin upon experimental lethal pneumococcal infection.


The perivascular space of the pineal gland.


Embryo-specific serum proteins in the chick.


Loss of memory in mice as related to regional inhibition of cerebral protein synthesis.


Amino acid excretion after thermal burn.


Prevention and reversal of adrenal-regeneration hypertension with hydrochlorothiazide.


Effect of chlorothiazide on the water and electrolyte content of the tissues.


Transplantation of skeletal muscle into a host with muscular dystrophy.


Radioautographic study of cellular replacement in the adrenal cortex of male rats.


Studies in vitro on the autohemolysis of normoblastic and megaloblastic marrow cells.


Gastric carcinomas and pulmonary adenomas in mice fed benzo (a) pyrene.


Site of action of atropine in blocking pressor response to increased intracranial pressure in chlorisondamine-treated dogs.


Restraining board device for experiments with untrained, unanesthetized dogs.


Subcutaneous carcinogenesis by 14C and 3H labelled polymethylmetacrylate films.


Screening report on the antitumor activity of purified Arctium Lappa extracts.


An experimental study on the vagus nerve investigated after the chromatolytic method using the very young cats with special reference to the nodose ganglion and to the individual viscera.


Sarcoidosis of the skeletal muscle with tumor formation. A case report and review of the literature.


Studies on X-agent.48.  Fluctuation of harder components of X-agent capable of affecting alkaline-aqueous solutions of neutral red.


Experience with polyethylene ring: 1955-1965. 1.


The partial latency and intramitochondrial distribution of carnitine-palmitoyltransferase (e.c.2.3.1.-), and the CoASH and carnitine permeable space of rat liver mitochondria.


Activation of trypsinogen and plasminogen by thrombin preparations.


Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin.


Tentative rules. Nomenclature of corrinoids.


The effect of indoleacetic acid on the incorporation of (32P)orthophosphate and (14C)adenine into plant nuclei in vitro.


Changes in potential difference and short-circuit current produced by electrical stimulation in a nerve-skin preparation of the toad.


Fluorescence studies on deuterated Chlorella vulgaris.


The steady-state properties of an ion exchange membrane with mobile sites. A study of the properties of the steady states of a system composed of two solutions separated by an ion exchange membrane having mobile sites is presented. It is assumed that the membrane is impermeable to coions; the solutions contain no more than two species of counterions, both of the same valence; and no flow of bulk solution occurs. Assuming that all ions are completely dissociated, behave ideally, and have constant mobilities throughout the membrane, explicit expressions are derived for the steady states of the electric current, individual fluxes, and concentration profiles as functions of the compositions of the solutions and of the difference of electric potential between them. The derived expressions are compared with those for an ion exchange membrane having fixed sites; and it is found that the expressions of certain quantities, such as the difference of electric potential between the two solutions for zero current or the ratio of the fluxes of the counterions as functions of the external parameters of the system, are the same for both types of membranes. On the other hand, differences in the behavior of the two types of membranes are found from other expressions-for example, the current-voltage relationship. In the mobile site ion exchanger the current asymptotically approaches finite limiting values for high positive and negative voltages while in the fixed site ion exchanger it is the conductance which approaches finite limiting values.


On the proposed energy switch in photosynthesis. This paper analyzes the "energy switch" that has often been proposed to direct quanta absorbed by a given photosynthetic unit alternately to the site of one and then the other primary reaction. Such a device is essential to the Franck-Rosenberg theory, but not to the Duysens-Witt-Kok (DWK) model, which needs to assume only that the reactions occur in series. If there is no energy switch, an incident quantum absorbed at any time by any particular pigment molecule stands a chance of ending up in the reactive site of either primary reaction. The "separate packages" model is a special case of this general picture. Without an energy switch, a series model requires a storage device to insure that a quantum will not be wasted if it arrives at the site of one reaction while the photosynthetic unit is set up to perform the other. Such a storage device can be appended to the DWK model. Alternatively, this model can be augmented by an energy switch. This gives what is commonly known as the "spillover model," a confusing name which we suggest be abandoned. As a clear-cut-though perhaps technically unfeasible-test of the energy switch hypothesis, we imagine a quantum injector, a hypothetical source of flashing light which delivers a single quantum to every photosynthetic unit with each flash. We aim this useful figment at an (equally hypothetical) photosynthetic system all of whose units are set up to perform the same primary reaction. If there is an energy switch, we can now prepare a "synchronous" photosynthetic apparatus in which each photosynthetic unit is undergoing the same reaction at the same time.


Use of Fourier series for the analysis of biological systems. In an attempt to quantitate the physical behavior of biological systems, Fourier analysis has been applied to the respiratory and circulatory systems by a number of investigators. The validity of this application has been questioned on the basis that these systems are nonlinear and not strictly periodic. If these objections were valid much of the more recent work in this field would have to be re-evaluated. The applicability of Fourier analysis to these two systems was therefore investigated, both theoretically and experimentally, using on-line analysis on a LINC (laboratory instrument computer) digital computer. In normal anesthetized dogs errors introduced by deviations from periodicity and linearity were found to be within the range of measurement errors. In sinusoidally perfused aortas the amount of second harmonic produced by the vessel was less than 5%. In addition, the magnitude of errors due to faulty determination of cycle length, sampling techniques, aliasing, and A-D (analogue to digital) conversion were evaluated and found to be within the noise level of the measuring equipment when appropriate techniques were employed. Utmost care has to be used in the coupling between a transducer and the system to be measured, and dynamic calibration before each experiment is a prerequisite for successful analysis. With presently available equipment the static measurement errors can be reduced to +/-0.2 cm H(2)O for pressure transducers, 0.1 cm(3)/sec for electromagnetic flowmeters, and 5 x 10(-4) cm for measurement of radius changes. The frequency response of this equipment once properly coupled to the system is flat to at least 20 cycle/sec.


Response of nonspherical biological particles to alternating electric fields. The stable orientation evoked by an alternating electric field is discussed for biological particles of arbitrary shapes and compositions. Ellipsoidal particles with and without shells are treated as special cases. It is shown that as the frequency of the electric field changes there may be sudden jumps in the stable direction as well as gradual changes.


Interaction between cations in hydrophobic solvent-saturated filters containing fixed negative charges. Previous investigations have shown that Millipore filters bearing fixed negatively charged sites saturated with organic solvents behaved like cation exchangers. In this study the mobilities of some cations in bromobenzene-saturated filters were determined at various membrane compositions. Appreciable interaction between counterions in the membrane was demonstrated; e.g., Na(+) was about four times more mobile in a Na(+) membrane than in a K(+) one. The qualitative nature of the interaction could be summarized as follows: the bringing together of rapid and slow counterions in the membrane made the fast ion faster and the slow ion slower. Possible mechanisms for such an interaction are discussed. A quantitative estimation of K and Na mobilities and selectivity factors at various K-Na fractions in the membrane was made. The above parameters were used to compute the potential difference in a K-Na bi-ionic cell. The calculated bi-ionic potential was found to agree reasonably well with the measured value.


Spectral studies of a chlorophyll pigment with fluorescence maximum at 698 mu. A chlorophyll type pigment (F698) fluorescing maximally at 698 mmu at 77 degrees K has been observed in preparations of chlorophyll. This fluorescence is quenched by small amounts of naturally occurring materials, including plastoquinone and the ubiquinones, and by nitrobenzene, probably by formation of a nonfluorescent complex. Fluorescence quenching does not occur in the presence of carotenes, xanthophylls, or reduced plastoquinone and ubiquinone. The fluorescence is sharply temperature dependent, with a steep rise in intensity occurring at 165 degrees K. At 77 degrees K the fluorescence yield is between 0.8 and 1.0. The red absorption maximum of the pigment is at 675 mmu at room temperature and at 688 mmu at 77 degrees K. In vivo, a low temperature emission is also observed at 698 mmu, and this fluorescence is quenched by nitrobenzene. It is proposed that the pigment found in vitro is also the one responsible for emission at 698 mmu in vivo. A reaction of F698 with plastoquinone is suggested as the primary photochemical step in system II of photosynthesis.


Correlation between the distribution of amino acids and alpha helices.


The electrical conductance of semipermeable membranes.


Purification and some properties of alpha-amylase from rabbit skeletal muscles.


Aphagia, produced by destruction of the dorsomedial amygdala in dogs.


Studies on the stability of light-sensitive corrinoid-protein complexes.


Antidiuretic activity of the hypothalamus, neurohypophysis and blood plasma in various states of water metabolism in the guinea pig.


Chemotherapy and surgery of spontaneous tumors of mice.


The vasopressin content in perfusion fluid from the hypothalamus in conscious chronic dogs.


Quantitative evaluation of the radiosensitivity of cells of a transplantable rhabdomyosarcoma in the rat.


The enhancement of the after effect of ionizing radiation by a cytotoxic methylhydrazine derivative.


Some aspects of oestrogen metabolism in cases of human mammary neoplasias.


Quantitative separation and estimation of steroids by thin-layer chromatography. I. Determination of progesterone and testosterone propionate in oil solutions.


Incorporation of tritium-labeled thymidine and lysine into chromosomes of cultured human leukocytes. The incorporation of thymidine-H(3) and lysine-H(3) into human leukocyte chromosomes was studied in order to determine the temporal relationships between the syntheses of chromosomal deoxyribonucleic acid and chromosomal protein. The labeled compounds were incorporated into nuclei of interphase cells. Label from both precursors became apparent over the chromosomes of dividing cells. Incorporation of thymidine-H(3) occurred during a restricted period of midinterphase (S) which was preceded by a nonsynthetic period (G(1)) and followed by a nonsynthetic period (G(2)). Incorporation of lysine-H(3) into chromosomal protein occurred throughout interphase. Grain counts made over chromosomes of dividing cells revealed that the rate of incorporation of lysine-H(3) into chromosomal protein differed during various periods of interphase. The rate of incorporation was diminished during G(1). During early S period the rate of incorporation increased, reaching a peak in late S. The high rate continued into G(2). Thymidine-H(3) incorporated into DNA was distributed to mitotic chromosomes of daughter cells in a manner which has been referred to as a "semi-conservative segregation." No such semi-conservative mechanism was found to affect the distribution of lysine-H(3) to the mitotic chromosomes of daughter cells. Therefore, it is concluded that synthesis of chromosomal protein and its distribution to chromosomes of daughter cells are not directly influenced by synthesis and distribution of the chromosomal DNA with which the protein is associated.


The rapid resolution of naturally occurring amino acids by thin-layer chromatography.


The use of diphenylamine-alanine-phosphoric acid reagent in the detection and differentiation of monosaccharides and their derivatives on paper chromatograms.


Mobilities of amino acids and peptides in paper electrophoresis.


Chromatographic analysis of photosensitizing dyes.


Separation of some inorganic ions by reversed-phase partition chromatography on thin layers.


A simple reproducible technique for sample introduction in analyses of volatile fatty acids by gas chromatography.


Gas-chromatographic analysis of tri-n-butyl phosphate.


Quantitative determination of griseofulvin by gas-liquid chromatography.


Gas chromatography of halogenated carbamates. 3. Meta-fluorosulfonylphenyl derivatives.


Reaction gas chromatography. I. Catalytic aromatization of alicyclic and heterocyclic compounds.


The pH-dependent elution of malonaldehyde during gel filtration on Sephadex G-10.


An adjustable column end-piece for gel filtration.


Separation of transfer-ribonucleic acid from deoxyribonucleic acid by gel filtration.


Decrease of tailing of chromatographic peaks.


Infrared microspectrometry of capillary gas chromatography effluents and of gas-phase free radicals.


Structure elucidation of mono-(hydroxymethyl)- and di-(hydroxymethyl)-3-hydroxypyridines.


Destaining apparatus for disc electrophoresis gels by current at right angles to gel axis.


Use of "lipophilic" Sephadex in peptide synthesis.


Separation of protected peptides on methylated Sephadex.


Column chromatography of some methionine peptides.


Separation of vitamins K2 on capillary columns of methylated Sephadex.


Separation of aliphatic dicarboxylic acids by thin-layer chromatography (TLC).


Separation of the methyl esters of benzenecarboxylic acids by thin-layer chromatography.


An improved method for charring lipids on thin-layer chromatograms.


Biochemistry of sphingolipids. VII. Separation of isomeric sphingosine bases as their dinitrophenyl derivatives.


Thin layer chromatography of polynitrophenols, nitrosophenols, nitrohydroquinones and related compounds.


A method for quantitative thin-layer chromatography.


The cytogenetics of Lotus. XII. Thin-layer chromatography in the separation of secondary phenolic compounds in Lotus (Leguminosae).


Detection and thin-layer chromatography of isomeric chlorophenols and their derivatives. I. N-trichloracetyl carbamates.


Thin layer chromatography of aliphatic nitramines.


Preparation of a firm polyamide adsorbent for thin-layer chromatography.


Thin-layer chromatography of some phenothiazine derivatives.


A colour reaction for psychotropic drugs on thin layer chromatograms.


Separation of hydroxocobalamin and cyanocobalamin by thin-layer chromatography.


Ion exchange chromatography of some acidic and aromatic amino acids.


The detection of amino compounds on paper chromatograms with diazotized p-nitroanaline.


Contamination of paper chromatograms by scissors.


C14-labeled pyrrolidonecarboxylic acid as a contaminant in chromatography.


2-Dimensional paper chromatography interspersed with reaction on the paper.


Detection of tert.-butyloxycarbonyl derivatives on paper and thin-layer chromatograms.


A simple technique for detecting homogentisic acid on paper chromatograms.


Double spot formation in chromatography of imidazolepropionic acid.


Variation of Rf of vitamin B6 group with pH.


A new method of detection of inorganic phosphate on paper.


Separation of inorganic phosphates by molecular-sieve chromatography.


Detection of metals on paper chromatograms with Rhodamine B.


Application of an electron capture detector to the determination of dibromoethane in gasolines.


Theory of sorption chromatography. II. Numerical calculations.


Separation of maltodextrins by charcoal chromatography.


The correlation between the stereochemistry of some indole and oxindole alkaloids and their behaviour on thin layer chromatograms.


Studies on the flame ionization detector signal in the presence or organosilicon compounds. A method for the registration of the detector performance.


Separation of epoxy, hydroxy, halohydroxy and keto fatty acids and derivatives by thin-layer chromatography.


Quantitative thin-layer chromatography of chenodeoxycholic acid and deoxycholic acid in human duodenal contents.


Deoxyribonucleic acid base composition in the genus Pseudomonas.


A comparative study of Pseudomonas pseudomallei and Bacillus mallei.


Studies on the biology of some oxyurid nematodes. I. Factors in the development of eggs of Aspiculuris tetraptera Schulz.


Studies on the biology of some oxyurid nematodes. II. The hatching of eggs and development of Aspiculuris tetraptera Schulz, within the host.


Follow-up of P-32 labelled infective larvae of Wuchereria bancrofti in the skin of a kitten.


Two unusual cases of cysticercosis in man in Rhodesia.


Intake and migration of the microfilariae of Onchocerca volvulus (Leuckart) in Simulium damnosum Theobald.


Studies on filariasis. I. The migration of the infective larvae of Brugia pahangi in Aedes togoi and their loss from the mosquito under experimental conditions.


A biological technique to assess numbers of Fasciola hepatica metacercariae on pastures.


Susceptibility of some planorbid snails to infection with Schistosoma rodhaini from Kenya.


Relationships between schistosomes and their molluscan hosts in Africa.


Changes in brightness index, saturation, and hue produced by luminance-wavelength-temporal interactions.


Effects of spatiotemporal, sinusoidally varying stimuli on brightness perception.


Influence of choline on the reticuloendothelial system and on survival after experimental shock.


Mechanism of x-ray sensitization of bacteriophage T7 by 5-bromouracil.


Natural and radiation-induced chromosomal polymorphism in Drosophila.


Differential mutagenicity of the amine and amide derivatives of nitroso compounds in Drosophila melanogaster.


A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia.


Evidence for nonrandom rejoining of chromatid breaks and its relation to the origin of sister-chromatid exchanges.


Comparison of frequency patterns between whole-body and fractional mutations induced by x-rays in Drosophila melanogaster.


The ecology, functional morphology and taxonomy of Echeneibothrium Beneden, 1849 (Cestoda: Tetraphyllidea), a revision of the genus and comments on Discobothrium Beneden, 1870, Pseudanthobothrium Baer, 1956, and Phormobothrium Alexander, 1963.


Electron microscope studies of Fasciola hepatica. I. The ultrastructure and interrelationship of the parenchymal cells.


Activity and the orthokinetic response of larval Trichonema to light.


The effect of the synthetic plant-growth substance, 2,4-dichlorophenoxyacetic acid, on the host-parasite relationships of some plant-parasitic nematodes in monoxenic callus culture.


Immunity to Trichinella spiralis. I. The immunity produced by mice to the first four days of the intestinal phase of the infection.


A study of resistance to cycloguanil in Plasmodium gallinaceum in chicks.


The fine structure of the intestine and hind gut of the larva of Trichinella spiralis.


The functional morphology of the genitalia of the spermatophore-producing monogenean parasite Diplectanum aequans (Wagener) Diesing, with a note on the copulation of the parasite.


The significance of size in the immature stages of the Ixodoidea.


Orthodontics for adults.

Orthodontics for adults.


The basic trypsin inhibitor of bovine pancreas. VI. Sequence studies and disulphide linkages.


The properties of glycerol dehydratase isolated from Aerobacter aerogenes, and the properties of the apoenzyme subunits.


A cell-free protein synthesis system from pupae of Tenebrio molitor.


Changes in some chemical constituents of Galleria mellonella larvae in relation to growth and morphogenesis.


Analogues of nucleoside polyphosphates. Synthesis of an analogue of ATP containing a hypophosphoric bond.


Biochemical mechanisms of drug resistance. 3. Differences in the metabolism of mouse leukaemic cells sensitive and resistant to 5-azacytidine.


Methylputrescine as possible precursor of nicotine in Nicotiana rustica.


The repeating units of membranes.

The repeating units of membranes.


Responses of bulbar reticular units to hypothalamic stimulation in the rat.


Inhibition of sympathetic discharge by stimulation of the medulla oblongata in the rat.


Detection and management of latent diabetes in commercial pilots.


Influence of vibrations on chromosomes.

Influence of vibrations on chromosomes.


Relationship between character and behavior disorder and aircraft accidents. An illustrative case.


Task interruption and performance decrement following rapid decompression.


Studies on Plasmodium (Vinckeia) cephalophi of the grey duiker (Sylvicapra grimmia).


Cysticercosis and epilepsy in Africans: a clinical and serological study.


Astiban therapy of urinary schistosomiasis: a quantitative evaluation.


Host-parasite relationships in schistosomiasis. 3. The effect of temperature on the survival of Schistosoma mansoni miracidia and on the survival and infectivity of Schistosoma mansoni cercariae.


Studies on the ecology of snails transmitting urinary schistosomiasis in Western Nigeria.


The distribution on the human body of bites inflicted by phlebotomine sandflies in British Honduras.


Observations on the resistance of West African N'dama and Zebu cattle to trypanosomiasis following challenge by wild Glossina morsitans from an early age.


Trypanosome infections in the mouthparts of Glossina morsitans Westw.: variations in frequency and extent of labral infections with age.


Leptospirosis as a cause of pyrexia of unknown origin in Thailand.


Mechanism of induction of immunological tolerance. I. Localization of tolerance-inducing antigen.


The characteristics of F1 and backcross hybrids between "high leukaemia" (AKR) and "autoimmune" (NZB) mouse strains.


The loss of radioactivity during the preparation of autoradiographs from rats injected with iodine-labelled antigens.


The reticulocyte response in calves made anaemic by phlebotomy.


Variations with age in the plasma iron and total iron-binding capacity in dairy calves.


Human serum alkaline phosphatase variants and their association with the ABO blood groups in an Australian sample.


The effect of androstanazole on the body weight gain of sheep.


The utilisation of the chest wall reflex in alleviating acute barbiturate intoxication in the dog.


A new vaccine for Babesia argentina infection prepared in splenectomised calves.


Comparison of direct microscopic and guinea pig inoculation techniques for demonstrating leptospiras in bovine urine.


Embryonic mortality in merino ewes exposed to high ambient temperatures.


Multiple molecular weight forms of staphylococcal nuclease.


Temperature-dependent association-dissociation of Streptococcus lactis intracellular proteinase.


Isolation and properties of a carboxylesterase from pig kidney.


The reconstitution of clostridial ferredoxin.


Transglutaminase as a blood clotting enzyme.


Hybridization of messenger RNA with DNA from plants.


Incorporation of [G-14cC]shikimate and [U-14C]para-hydroxybenzoate into phytoquinones and chromanols.


Substrate binding to hydroxyketoglutarate aldolase.


The inhibition of catalase by ascorbic acid.


Effect of aldosterone on Na efflux in single Maia muscle fibres.


P700 and cytochrome F in particles obtained by digitonin fragmentation of spinach chloroplasts.


Fluorescence and the structure of proteins. 8. Iodination of ribonuclease modified by subtilisin.


Fluorescence and protein structure. IX. Relationship between tyrosine fluorescence and various stages in denaturation of ribonuclease.


Interaction between gelatin solutions and tobacco mosaic virus.


Effect of urea on the aggregation of myosin at low ionic strength.


The effect of heat on the ultraviolet spectral properties of tobacco mosaic virus ribonucleic acid complexed with Hg(II).


Absorption and fluorescence spectra of spinach chloroplast fractions obtained by solvent extraction.


Amino acid transport by the small intestine of the rat. On the counterflow phenomenon as a cause of the accelerating effect of leucine on the transintestinal transport of diamino acids.


The metabolism of glycine and glycollate by pea leaves in relation to photosynthesis.


Phosphate partition and transport in the Ehrlich mouse ascites tumor cell.


Observations on the active transport of bile salts by rat and hamster ileum in vitro.


A nuclear magnetic resonance study and proton exchange of poly-L-alanine.


The fluorescence emission spectra of chlorophyll a forms from Euglena.


The occurrence of poly-beta-hydroxybutyrate in the blue-green alga, Chlorogloea fritschii.


Proton magnetic resonance study of nucleic acids.


A statement of policy by the managing editors of Biochimica et Biophysica Acta.


Specificity of the inhibitory effects of sugars on intestinal amino acid transfer.


Studies on the biological control of glycogen metabolism in liver. I. State and activity pattern of glycogen phosphorylase.


The role of ascorbic acid in the biosynthesis of collagen. I. Ascorbic acid requirement by embryonic chick tibia in tissue culture.


The role of ascorbic acid in the biosynthesis of collagen. II. Site and nature of ascorbic acid participation.


Lyase activity of inducible S8-depolymerases from Bacillus palustris.


Non-suppressible insulin-like activity of human serum. I. Physicochemical properties, extraction and partial purification.


Non-suppressible insulin-like activity of human serum. II. Biological properties of plasma extracts with non-suppressible insulin-like activity.


Mode of action of glucocorticoids. II. Early effects of triamcinolone on amino acid incorporation into various tissues in vivo.


Mode of action of glucocorticoids. 3. The inhibition of amino acid incorporation by thymus subcellular fractions in vitro following administration of triamcinolone.


The separation of optical isomers of beta-methyllanthionine.


Stimulation by hydrocortisone of premature changes in the developmental pattern of glutamine synthetase in embryonic retina.