A study of the interaction between motoneurones in the frog spinal cord. 1. A short-latency interaction between motoneurones has been studied with intracellular and root potential recordings from the isolated spinal cord of the frog. Antidromic stimulation of one ventral root causes brief depolarization (VR-EPSP) of the motoneurones of adjacent, non-excited motoneurones. The summed activity of many such VR-EPSPs can be seen as a brief depolarization (VR-VRP) passing out an adjacent ventral root.2. Both intracellular and root-recorded signs of this interaction are graded in amplitude.3. It was found that this interaction decreased with increasing temperature. This is in contrast to the behaviour of the ventral root potential resulting from dorsal root stimulation (DR-VRP) or the dorsal root potentials resulting from either dorsal root (DR-DRP) or ventral root (VR-DRP) stimulation, all of which increased in amplitude from below 10 to about 17 degrees C.4. Pharmacological evidence suggests that the interaction between motoneurones is not chemically mediated. The VR-VRP was not affected by a large variety of transmitter blocking agents, including curare, dihydro-beta-erythroidine, atropine, succinylcholine, hexamethonium and DOPA, while the VR-DRP, which probably originates with the release of ACh from an axon collateral, was consistently blocked.5. Mg(2+) suppressed the VR-VRP more slowly than the other potentials, and this suppression was increased by adding Ca(2+), rather than reversed, as in the case of the other root potentials, which are presumably mediated by chemical transmission.6. The interaction between motoneurones is strongly facilitated by orthodromic depolarization of the motoneurones being antidromically stimulated. Extracellular recordings within the cord support the conclusion that this facilitation is a result of the enhancement of antidromic invasion, perhaps especially of the dendrites, by slight depolarization.7. One VR-VRP (or VR-EPSP) first suppresses response to another (for about 10 msec), then facilitates response to the second, with maximum effect around 20-40 msec. This is the case whether both stimuli go to the same or to different ventral roots, although occlusion is less and facilitation greater in the latter case. Occlusion of the VR-EPSP also results from full excitation of the cell in which recording is being done.8. The mechanism of this interaction remains uncertain, but it would seem likely that overlapping dendrites of adjacent motoneurones interact with each other electrically through close apposition or specialized contacts. Occlusion would result from the refractoriness of strongly depolarized dendrites, facilitation from the enhancement of invasion of antidromically stimulated motoneurones by the weaker (or residual) depolarization occurring after earlier activity of motoneurones or their dendrites.


Therapeutic abortion: indications and technics.


Ureteral suspension for prevention of ureteral complications following radical Wertheim hysterectomy.


Fetal hazard after rupture of the membranes. A report from the collaborative project.


Dynamic urethrocystograms.

Dynamic urethrocystograms.


Gas-liquid chromatography of some cholesterol analogs.


Late results of surgical treatment for renovascular hypertension.


Combined extra- and intrauterine pregnancy carried to term.


The inhibitory effect of aminoguanidine on histamine catabolism in human pregnancy.


The diagnosis of intra-uterine foetus death and elucidation of the aetiology of "missed abortion" by means of semi-quantitative gas chromatographic determination of urinary oestriol and pregnanediol.


Epsilon-aminocaproic acid (epsilon-ACA) on threatened abortion.


Transaminase activity during oral contraceptive therapy.


Two cases of spontaneous perforation of the caecum following caesarean section.


Primary carcinoma of Bartholin's gland.

Primary carcinoma of Bartholin's gland.


Post-caesarean menouria (Youssef's syndrome).


The clinical significance of standard score discrepancies betwen intelligence and social competence.


"Extreme" forms of normal child development.


Development of language: suggestions for a verbal fallout model.


Body size, shape, and composition of several types of athletes.


Work capacity of the Japanese related to age and sex.


Body height and predisposition for certain sports.


A comparative study of the brachial pulse wave and its time derivatives among athletic, normal and pathological subjects.


Central venous blood for monitoring pH and pCO2 in the critically ill patient.


Experimental large volume hemodilution with plasma.


Observations from the respiratory history of 30 patients with normal pulmonary surfactant.


The fate of the surface heparin of GBH-coated plastics after exposure to the blood stream.


Sodium/potassium ratios in papillary muscle biopsies obtained during mitral valve replacement.


Hemodynamic responses to exercise and to isoproterenol following total correction of Fallot's tetralogy.


Instrumental perforation of the esophagus. What is conservative management?


Primary pulmonary lymphoma. Review of the literature and two case reports.


A comparative study of the physiology and physics of pleural drainage systems.


The hemorrhagic pulmonary-renal syndrome of Goodpasture. A case report.


An experimental study of respiratory mechanics following chest surgery.


Ball-valve replacement for aortic valvular disease. A follow-up evaluation.


A combined gas and heat exchanger.

A combined gas and heat exchanger.


Cardiopulmonary dynamics of acute complete heart block and ventricular stimulation in the dog.


An EEG study of 2-phynyl-3-ethylaminobicyclo-(2,2,1)-hepatane HCl (fencamfamin hydrochloride).


The influence of protein intake on RNA and protein synthesis in rat liver.


Hyposmia secondary to excision of the olfactory epithelium. The definition of primary and accessory areas of olfaction.


Analog computer simulation of cardiac muscle contraction.


The effects of amine depleting agents on the toxicity of amphetamine in aggregated mice.


Simultaneous uptake and release of individual free fatty acids in human forearm muscle during exercise.


Effects of lithium ions on the rat superior cervical ganglion.


Effects of dimethyl sulfoxide on serum enzymes and tissues in exercised rats.


Idiopathic myocardiopathy. II. Treatment and the role of long term bed rest.


Problems of diagnosis in chronic diseases. II.


Hyperplastic cholecystoses.

Hyperplastic cholecystoses.


PKU laws, a model for the future?

PKU laws, a model for the future?


Circulatory arrest. I. Acid-base factors for survival using extracorporeal bypass without thoracotomy to produce profound hypothermia.


Circulatory arrest. II. Alkalosis in total circulatory arrest of two hours' duration.


Treatment of chronic venous leg ulcers with raw silk.


Post radical mastectomy edema of the arm: the role of phlebitis.


Fresh and frozen homologous venous grafts for arterial repair.


Relation of blood cell aggregation to capillary resistance.


Observations on the effects of histamine and serotonin in the rabbit ear chamber.


Effect of cyclandelate upon cerebral blood flow in patients with "stroke".


Frequency and meaning of some red blood cells and haemoglobin abnormalities in a sample of the population from Apulia (South Eastern Italy).


Home care--why the hesitancy?

Home care--why the hesitancy?


The air pollution control program of the Province of Ontario.


Public health programs as social change: ambiguities and conflicts.


Change and the public health nurse.

Change and the public health nurse.


Enquiry into sudden death in infancy.

Enquiry into sudden death in infancy.


The use of an electronic computer in a health department.


Long-stay patients in Canadian mental hospitals, 1955-1963. Changes in the number and characteristics of patients in Canadian mental hospitals during 1955-1963 were studied in order to assess the future need for long-term hospital care.Despite marked increases in the number of first admissions and readmissions, the average number of patients in hospital decreased 6% from 49,537 in 1955 to 46,498 in 1963.Patients who were "long stay" in 1955 continued to leave hospital at the same rate during the years 1960-1963 as during 1955-1959. No "hard core" of long-stay patients with reduced potential for discharge seemed to have formed by 1963.Since 1955 the number of "admissions" remaining continuously hospitalized has progressively decreased for the elderly and for patients with psychoses. No build-up of new long-stay patients from patients with repeated short admissions was evident.The estimate of the Royal Commission on Health Services that the ratio of patients in mental hospitals could be reduced from 3.0 per 1000 in 1961 to 1.5 per 1000 by 1971 seems feasible.


Factitious aortic valve insufficiency.

Factitious aortic valve insufficiency. One hundred consecutive aortograms, performed with careful attention to recommended technical details, were reviewed to identify cases of "factitious" aortic valve insufficiency, viz. aortic regurgitation seen during aortography for which there is no clinical evidence. Five patients with this condition were identified. Two of these subsequently underwent mitral valve replacement under cardiopulmonary by-pass. Aortic insufficiency was not detected during this procedure and the aortic valve appeared to be anatomically normal at postmortem examination. That factitious aortic insufficiency may exist should be remembered when aortography is used to differentiate aortic from pulmonary valve insufficiency.


On the futility of legalizing abortion.

On the futility of legalizing abortion.


Skin temperature recording with phosphors: toxicity studies on animals. In a previous communication in this journal, a method was described for converting invisible thermal patterns of the human skin into a detailed visible picture. At that time, the question of possible toxicity of the thermographic phosphor was raised. Toxicity studies conducted on laboratory animals indicate that the probability of toxic side reactions resulting from the use of zinc-cadmium sulfide phosphor spray is very low.


Intravenous promazine: a cautionary note.


Recent developments in the control of commensal rodents.


Rash associated with Coxsackie A9 infection. Coxsackie A9 virus was identified by the authors during the fall of 1965 in Montreal in six children with fever and exanthem. Three of the six children were siblings. The exanthem was centrally distributed as described by Lerner et al. and consisted of discrete maculopapules 3 to 4 mm. in diameter. The viral agent was recovered and identified in tissue culture in five cases, while in the sixth Coxsackie type-A lesions were produced in suckling mice. Serological confirmation was obtained in two patients from whom sera were available. In contrast, no exanthem was observed in three older patients with a diagnosis of aseptic meningitis associated with Coxsackie A9 virus. In only one of 16 patients with Coxsackie B virus infection was an exanthem observed during the same period.The true incidence of Coxsackie A9-associated exanthems is difficult to determine because of the benign nature of the disease.


Separation of mixtures of fatty acids, alcohols and esters or glycerides by thin layer chromatography.


Simple preparative scale thin layer chromatography apparatus.


Isolation of 5-hydroxymethylfurfural from cigarette smoke condensate.


Renal tubular reabsorption of bromide compared with chloride.


The action of exogenous aldosterone on the secretion and composition of drug-induced sweat.


The assay of renin in single glomeruli and the appearance of the juxtaglomerular apparatus in the rabbit following renal artery constriction.


Strength-duration curves for the production of cutaneous pain by electrical stimuli.


Some factors determining the adrenal response to metyrapone (SU 4885).


Plasma renin concentration in relation to changes in posture.


Bronchial insufflation in apnoeic respiration.


The significance of a raised central venous pressure during sodium and water retention.


Studies of plasma protein metabolism. 3. Fibrinogen in burned patients.


The variability of measurements of casual blood pressure. I. A laboratory study.


Total body protein, collagen and non-collagen protein in infantile protein malnutrition.


The variability of measurements of casual blood pressure. II. Survey experience.


Neurological deficits associated with pelvic fractures.


The response of experimental cerebral edema to glucosteroid administration.


Stapling technique in segmental vein autografts and end-to-end anastomosis of small vessels in dogs. Utilization of the operating microscope.


An experimental study of the effects of a plastic adhesive, methyl 2-cyanoacrylate monomer (M2 C-1) in various tissues.


Effects of methyl 2-cyanoacrylate adhesives on the somatic vessels and the central nervous system of animals.


Fatality from ruptured intracranial aneurysm after coating with methyl 2-cyanoacrylate (eastman 910 monomer, M2 C-1). Case report.


Intracranial lipoma. Case report.

Intracranial lipoma. Case report.


Angiomatous malformation as a cause of cerebral calculus. Case report.


Sarcoma: a possible late result of effective radiation therapy for pituitary adenoma. Report of two cases.


Incarceration of a vertebral artery in the cleft of a longitudinal fracture of the skull. Case report.


A new multipurpose human brain depth probe.


Third ventriculostomy by puncture of the lamina terminalis and the floor of third ventricle.


Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage. Section II. General survey of cases in the central registry and characteristics of the sample population.


Tetanus prophylaxis in Canada.

Tetanus prophylaxis in Canada.


Occupational health.

Occupational health.


The metabolic cost of industrial activity in relation to weight.


Devices for the teaching of expired air resuscitation.


Neisseria control.

Neisseria control.


Who meeting on Neisseria research.

Who meeting on Neisseria research.


The practical joke that "misfired".

The practical joke that "misfired".


Upsurge of interest in mental health.

Upsurge of interest in mental health.


Preparation for living.

Preparation for living.


National health Service prescriptions.

National health Service prescriptions.


New leprosy regulations.

New leprosy regulations.


Food Additives and Contaminants Committee's report on solvents.


Chronic bronchitis.

Chronic bronchitis.


Food hygiene education.

Food hygiene education.


"Towards respiratory health".

"Towards respiratory health".


Hemolytic-uremic syndrome. Clinical and pathological considerations.


New syndrome of neonatal hypoglycemia. Association with visceromegaly, macroglossia, microcephaly and abnormal umbilicus.


Post-transfusion purpura.

Post-transfusion purpura.


Resistance-transfer factor in Enterobacteriaceae.


Factor IX deficiency and prolonged bleeding time.


Myocardial perforation by a permanent transvenous pacemaker.


Black-copper reduction reaction simulating alkaptonuria. Occurrence after intravenous urography.


Infectious drug resistance.

Infectious drug resistance.


Review of 210 deaths by poisoning in British Guiana (1959-1964).


The results of treatment by resection of two hundred cases of tuberculosis in Trinidad and Tobago.


The intra-uterine contraceptive device in Jamaica. (A preliminary review).


Retropubic prostatectomy in patients with long standing suprapubic cystostomy.


Arterial blood pressure in Jamaican women with and without uterine fibroids.


The validity of surveys of heights and weights of Jamaican schoolchildren.


Further investigations on the toxicity of Crothalaria fulva in Jamacia.


Psychiatric education for the Caribbean.


The effect of instruction and labeling on the number of medication errors made by patients at home.


Biomedical communications in the Public Health Service.


Improved drug control through communications.


Control of drug samples at the Watts Hospital.


A study of the Pharmacy Service, Department of Hospitals, city of New York.


Background for U.S.P., N.F. and N.D. Medicare requirement.


Stability assays of ophthalmic solutions.


Assay of atropine sulfate solutions.

Assay of atropine sulfate solutions.


Assay of pilocarpine hydrochloride solutions.


The substrate specificity of atypical cholinesterase in relation to phenotypes.


Inhibition of purified rat liver mitochondrial monamine oxidase by trans-2-phenylcyclopropylamine.


Sulfur and selenium isologs related to acetycholine. and choline IV. Activity in the electroplax preparation.


Identification of substances interfering with the fluorometric determination of brain histamine.


Effect of vitamin K deficiency on the adenosine nucleotide content of chicken liver.


Tannic acid in colon examinations.

Tannic acid in colon examinations.


The post-operative heart.

The post-operative heart.


Selective visceral angiography using a percutaneous axillary technique.


The classification, clinical value and mechanism of sella turcica changes in raised intracranial pressure.


A new technique for the measurement of metacarpal density.


Effects of some metabolic inhibitors on x-ray dose-response curves for the survival of mammalian cells in vitro, and on early recovery between fractionated x-ray doses.


Case reports. Benign duodeno-colic fistula.


Spontaneous renal and perirenal emphysema.


Hepato-phrenic interposition of the fundus of the stomach.


Adaptations of disposable intravenous infusion equipment in diagnostic radiology.


Non-ossifying fibroma of bone.

Non-ossifying fibroma of bone.


Notation and formulae for dose specification and calculations in radiotherapy.


Clinical application of functional test and methods of investigation of placental disorders.


A right true unicornuate uterus with unilateral renal agenesis.


Venous distensibility in patients with varicose veins. Forearm veins were studied to determine whether patients with primary varicosity of the saphenous veins had a generalized abnormality of the venous system. Distensibility of the superficial forearm and hand veins was measured in 25 patients with varicosity of the saphenous veins, and in 25 control subjects. Patients with saphenous varicosity had a significantly greater distensibility of the undistorted forearm veins than control subjects. Hysteresis of distensibility curves was more prnounced in patients with varicosity than in control subjects; mean hysteresis index was 0.65 +/- 0.06 versus 0.28 +/- 0.02 in controls. These investigations suggest that an increased distensibility of the venous system is the predisposing factor in the development of varicose veins.


Rupture of the uterus and hemorrhagic diathesis.


Cutaneous reactivity to different mycobacterial antigens in patients with tuberculosis. Mycobacterium tuberculosis and the atypical mycobacteria may give rise to similar clinical pictures. Although the etiological separation of these diseases requires special cultural techniques, the identity of the causative mycobacteria may be suggested following the simultaneous use of a series of antigens. Thus, in spite of cross-reactivity to photochromogen and to a lesser degree to scotochromogen antigens, patients with typical tuberculosis had the largest reaction to Old Tuberculin. Such simultaneous tests, when carried out with careful measurements in a standardized manner, are of diagnostic value in identifying the responsible mycobacterium.


The ground-glass clotting time. A sensitive screening test for blood coagulation defects.


Rectal procidentia--a rare complication of ulcerative colitis. Report of two cases in children.


Determination of genotypes by family studies. Report of five illustrative cases.


Carpal tunnel compression caused by hematoma associated with anticoagulant therapy. Report of a case.


Effect of vaccinia virus on malignant melanoma of hamsters.


Rorschach test correlates of dreaming and dream recall.


A comparison of normals and schizophrenics on a new scale of the Rorschach CET.


Hostility themes in the family TAT.

Hostility themes in the family TAT.


A model of pulse generation in the peripheral nervous system.


Multimodal interval distributions.

Multimodal interval distributions.


Oscillations in the amplitude of human peripheral nerve action potentials during repetitive stimulation.


Decision equation for binary systems. Application to neuronal behavior.


Experimental observations on a small active network.


The special-problem patient: victim or agent of splitting?


Competition, cooperation, and group cohesion in the ballet company.


Younger brothers of schizophrenics.

Younger brothers of schizophrenics.


An epidemic of emotional disturbance among leprosarium nurses in a setting of low morale and social change.


The struggle to create a sane society in the psychiatric hospital.


Schizophrenia in twins. An epidemiological-clinical study.


Obsessive-compulsive phenomena and catatonic states--a continuum. A five-year case study of a chronic catatonic patient.


Gas myelography and percutaneous puncture in the diagnosis of spinal cord cysts.


The Nisbet symposium. (3). Radiology in head injury.


A respiration-deficient mutant of Saccharomyces cerevisiae which accumulates porphyrins and lacks cytochromes.


Utilization of glutamine and glutamic acid by Chlorella pyrenoidosa.


The carotenoid pigments of a radiation-resistant Micrococcus species.


Biosynthesis of ubiquinone and ubichromenol in vitamin A-deficient rats.


Biosynthesis of non-phenolic aromatic C18 steroids in perfused human placenta.


The effect of insulin derivatives on the insulin response of assays in vitro.


Sodium hydroxide treatment of L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycine and its potentiated melanocyte-stimulating activity in vitro.


Effects of sex hormones and of potassium salts of fatty acids on the biosynthesis in vitro of cholesterol from [2-14C]mevalonic acid.


Inhibition by puromycin of amino acid transport by embryonic chick bone.


Amino acid transport in embryonic chick bone and rat costal cartilage.


Isolation of a peptide conjugate with the sequence phe-pro-val-orn from a cell-free system producing gramicidin S.


Purification and separation of platelet factor 2 (fibrinogen activating factor) and of platelet factor 4 (antiheparin factor).


Human fibrinopeptides. Isolation, characterization and structure.


A C-terminal sequence from ox growth hormone.


Properties of rat-tumor interferon.

Properties of rat-tumor interferon.


Allosteric enzyme models and their analysis by the theory of graphs.


Amino acid composition of chicken heart cytochrome c.


Products of strepzyme M action on Candida utilis cell wall.


S-(1-2-dicarboxyethyl)cysteine in urine and kidney.


Spontaneous oxidation of the gamma chain of the foetal haemoglobin component of cord blood.


Optical rotatory dispersion of G-actin-adenosine-5'-diphosphate.


Some physical properties of the human NN and Me-Vg blood-group antigens.


Ultraviolet absorption of N-glycosidic (lysine-sugar) linkages.


Inhibition tests of plant agglutinins from Laburnum alpinum and Cytisus sessifolius with various sugars and sugar derivatives. Indications of the type of linkage in certain disaccharides.


Liquid scintillation counting of 14C and 3H samples using glass-fibre or filter-paper discs.


Small scale preparation of [1-14C]fluoroacetic acid.


Synthesis of [1-beta-3H]testosterone.

Synthesis of [1-beta-3H]testosterone.


m-Carboxy-substituted aromatic amino acids in plant metabolism. II. The incorporation of shikimic acid into L-3-(3-carboxy-4-hydroxyphenyl)alanine in Reseda lutea L.


Some remarks on the future of dermatological research.


Cholinesterase in moles.

Cholinesterase in moles.


Juvenile melanoma. A histochemical study.


Esterase in epidermal dendritic cells of the mouse. A study of the histochemical properties and distribution of activity of the enzyme in relation to patterning in the tail.


The enzyme histochemistry of nodular subepidermal fibrosis.


The direction of growth of epithelium.

The direction of growth of epithelium.


Amyenteric achalasia--separate morbid entity.


Partial resection of small intestine in a hemophiliac A. Case report.


Cytological changes in bone marrow after repeated exposure to ionizing radiation.


Kinetics of Fe59 and Cr51 labelled erythrocytes in anemia of burned patients.


Experimental bacterio-viral osteitis.

Experimental bacterio-viral osteitis.


Agnostic alexia in a case of vascular lesions of the brain.


Evaluation of renal function in the course of acute leukemia in children.


An analysis of the forces acting on a psychiatric referral.


A simple glass apparatus for N.M.R. spectroscopy at low temperatures.


Further studies on the treatment of Burkitt's lymphoma.


A local cancer registry in a mission hospital in Uganda.


A note on an apparent similarity in distribution of onchocerciasis, femoral hernia and Kaposi's sarcoma in the West Nile district of Uganda.


The role of pain and its variations in effecting change.


The clinical approach in the evaluation of head pain.


Whiplash injuries and cervical pain.

Whiplash injuries and cervical pain.


Headaches as seizure equivalents.

Headaches as seizure equivalents.


Cause and mechanism of headache, pain and neuritis.


Medical practice and public relations.

Medical practice and public relations.


Recommended standard method for continuing dust fall survey (APM-1, Revision 1).


Avoiding the void.

Avoiding the void.


The public, the pharmacist and self-medication.


O-t-c antacids.

O-t-c antacids.


O-t-c laxatives.

O-t-c laxatives.


Problems in everyday practice.

Problems in everyday practice.


Postage stamp for pharmacy.

Postage stamp for pharmacy.


Your brother's keeper.

Your brother's keeper.


An attempt to isolate the etiologic agent of infectious mononucleosis.


Chromosome aberrations: increased incidence in bone marrow of continuously irradiated rats. The number of chromosomal aberrations in the bone marrow of continuously irradiated rats temporarily decreases after exposure, and then increases as the total dose and time after irradiation increase. This increase in aberrations is greater than that expected as a result of age alone.


Taxonomic status of tree shrews.

Taxonomic status of tree shrews.


The nature of the associations between Olpidium brassicae and lettuce big-vein and tobacco necrosis viruses.


Purification and properties of tomato ringspot virus and an RNA-deficient component.


Growth of Newcastle disease virus in a HVJ carrier culture of HeLa cells.


Electron microscopy of intracellular aggregates in pea (Pisum sativum) infected with clover yellow mosaic virus.


Flexuous rods in phloem cells of lime plants infected with Citrus tristeza virus.


T4 mutants unable to induce deoxycytidylate deaminase activity.


Acute bee paralysis virus, a cytoplasmic insect virus.


Electron microscopy of adenovirus-associated virus (AAV) in cell cultures.


Purification of pea enation mosaic virus.


Serum alpha-hydroxybutyric dehydrogenase in myocardial infarction.


Urokinase excretion in patients with renal diseases.


Pronounced polyuria and natriuresis following surgical relief of urinary tract obstruction.


Blood pressure, triglycerides and age in relation to coronary symptoms in hypercholesterolemia.


The relationship between pregnancy and haemorrhagic proctocolitis.


Neurogenic disorders of the bladder in diabetes mellitus. A clinical-roentgenological investigation.


Chest deformity in patients with congenital isolated ventricular septal defect.


Chronic rheumatic valvular heart disease in Iceland.


Intracardiac phonocardiography in the diagnosis of left ventricular--right atrial shunt.


Early ambulation in the treatment of myocardial infarction.


Serum and urinary urobilinoids in hepatic diseases.


Studies on iron absorption. V. The effect of ascorbic acid and ethyl alcohol on the absorption of iron in iron-deficient subjects.


Diagnostic significance of hypogammaglobulinemia.


Use of posterior culdotomy in pelvic operation.


Structural studies of haptoglobins. I. Hydrogen ion equilibria and optical rotatory dispersion of Hp 1-1 and Hp 2-2.


Intracellular distribution of ribonuclease activity in pea roots.


Efflux of enzymes from chicken muscle.

Efflux of enzymes from chicken muscle.


Differences in labelling of sRNA and rRNA of regenerating rat liver in the presence of actinomycin D.


A beef-heart cytochrome B dependent on nonheme iron for its reduction.


Investigation on the in vivo transformation of lupanine and related alkaloids.


Evaluation of the dispersion of electric activity in muscles during work of various intensity.


Enzymic transformation of glycerol to beta-hydroxypropionic aldehyde. II. Dissociation of the enzyme into two protein fragments.


Radioactivity--accident hazards.

Radioactivity--accident hazards.


Trichinosis: an epidemiological study in children using five immunological methods.


Western equine encephalitis in Alberta.

Western equine encephalitis in Alberta.


The Nineteenth World Health Assembly--May 1966.


Liaison between health and welfare agencies in a rural Ontario county.


Counteraction of the anti-mitotic effects of D20 in the dividing eggs of Argacia punctulata: a temperature-pressure analysis.


Plasma proteins and non-protein nitrogen in toad (Bufo melanostictus) during hibernation and non-hibernation.


Reinvestigation on the amino acid composition and C-terminal group of Taka-amylase A.


Transaminase of branched chain amino acids. I. Branched chain amino acids-alpha-ketoglutarate transaminase.


Phospholipid patterns in subcellular fractions of Mycobacterium phlei.


N- and C-terminal residues in the acid proteinase of Aspergillus saitoi.


Note on the chemical structure of 'subtilopentadecanoic' and 'subtiloheptadecanoic' acids.


Deterioration of unsaturated fatty acids on thin-layer plate.


Interconversion in vitro of the two forms of yeast beta-fructofuranosidase.


Effects of chondroitin sulphate upon acetylcholine-atropine and histamine-atropine systems.


Source mechanisms for unit activity in isolated crayfish central nervous system. As a tool for the identification of source mechanisms underlying the activity of single interneurons in the isolated crayfish abdominal cord, pulse trains from a sample of such neurons are statistically described (shape, mean, standard deviation, and serial correlation coefficient of interval distributions). These statistics were measured under four independent means of obtaining different average frequencies: (a) naturally occurring frequencies under standard conditions, (b) temperature control, (c) dc polarization, and (d) electrical stimulation of presynaptic fibers. 40 of 44 units studied had unimodal histograms, symmetrical when the mean interval was small and positively skewed with large means. Under standard conditions these units had SD = k (mean)(n), with n approximately 2. Fifteen single units were caused to fire at varied frequencies by cooling or dc stimulation. The resulting SD-vs.-mean plots for single units showed: (a)all points for a given unit fell approximately on a single line, regardless of whether temperature, dc, or neither was used to vary frequency, and (b) the average value of n (slope of log SD vs. log mean) for the fifteen units was 1.9 +/- 0.2. A paradox arises from interpretation of these data via gamma distributions. It is concluded that most of the spontaneous activity in the isolated abdominal cord may result from pacemaker activity within each cell and does not require a network of active units. Finally, the fact that the SD-mean relation was found not to depend measurably on temperature is interpreted as a useful restriction on models for neuronal noise processes.


Inhibitory action of tetracyclines on polynucleotide phosphorylase.


Behavior of delayed current under voltage clamp in the supramedullary neurons of puffer. Depolarizations applied to voltage-clamped cells bathed in the normal solution disclose an initial inward current followed by a delayed outward current. The maximum slope conductance for the peak initial current is about 30 times the leak conductance, but the maximum slope conductance for the delayed current is only about 10 times the leak conductance. During depolarizations for as long as 30 sec, the outward current does not maintain a steady level, but declines first exponentially with a time constant of about 6 msec; it then tends to increase for the next few seconds; finally, it declines slowly with a half-time of about 5 sec. Concomitant with the changes of the outward current, the membrane conductance changes, although virtually no change in electromotive force occurs. Thus, the changes in the membrane conductance represent two phases of K inactivation, one rapidly developing, the other slowly occurring, and a phase of K reactivation, which is interposed between the two inactivations. In isosmotic KCl solution after a conditioning hyperpolarization there occurs an increase in K permeability upon depolarization. When the depolarizations are maintained, the increase of K permeability undergoes changes similar to those observed in the normal medium. The significance of the K inactivation is discussed in relation to the after-potential of the nerve cells.


Analysis of K inactivation and TEA action in the supramedullary cells of puffer. Under the voltage clamp condition, the K inactivation was analyzed in cells bathed in the isosmotic KCl Lophius-Ringer solution. After conditioning hyperpolarization, the cells respond to depolarizations with increased K permeability, which in turn is decreased during maintained depolarizations. The steady-state levels of the K inactivation as a function of the membrane potential are related by an S-shaped curve similar to that which describes the steady-state Na inactivation in the squid giant axon. TEA reduced the K conductance by a factor which is independent of the potential, and without a shift of the inactivation curve along the voltage axis. The rapid phase of the K activation is less susceptible to TEA than the slow phase of the K activation. Hyperpolarizing steps remove the K inactivation, the rate of the removal being faster the larger the hyperpolarization from the standard potential of about -60 mv.


Cat heart muscle in vitro. IX. Cell ion and water contents in anisosmolal solutions. Cell contents of water, K, Na, and Cl have been determined in cat right ventricular papillary muscles immersed in solutions with and without NaCl when the external osmolality was varied with sucrose. The plot of cell water/kilogram dry weight (corrected for sucrose content) vs. (external osmolality)(-1) suggests that not less than 82% of water present in cells at physiological external osmolality is free to move across the cell membrane in response to an imposed osmotic gradient. Cells fail to increase their water content in very hypotonic solutions. For osmolalities greater than 5 times isosmolal, at which the mannitol space and the Cl(36) space are both equal to 100% of muscle water, rather large amounts of univalent cation appear to remain "bound" to the tissue.


The relation between salt and ionic transport coefficients. The reflection coefficient was originally introduced by Staverman to describe the movement of nonelectrolytes through membranes. When this coefficient is extended to salts, one has a choice of defining this term for the whole salt moving as a single electrically neutral component or for the individual ions of the salt. The latter definition is meaningful only in the absence of an electric field across the permeability barrier. This condition may be achieved with the voltage clamp or short-circuit technique and is especially useful in dealing with biological systems in which one rarely has only a single salt or even equal concentrations of the major anion and cation. The relations between the transport coefficients for the salt and its individual ions are derived. The special conditions which may result in negative osmosis through a charged membrane in the presence of a salt are discussed.


The steady-state transport of oxygen through hemoglobin solutions. The steady-state transport of oxygen through hemoglobin solutions was studied to identify the mechanism of the diffusion augmentation observed at low oxygen tensions. A novel technique employing a platinum-silver oxygen electrode was developed to measure the effective diffusion coefficient of oxygen in steady-state transport. The measurements were made over a wider range of hemoglobin and oxygen concentrations than previously reported. Values of the Brownian motion diffusion coefficient of oxygen in hemoglobin solution were obtained as well as measurements of facilitated transport at low oxygen tensions. Transport rates up to ten times greater than ordinary diffusion rates were found. Predictions of oxygen flux were made assuming that the oxyhemoglobin transport coefficient was equal to the Brownian motion diffusivity which was measured in a separate set of experiments. The close correlation between prediction and experiment indicates that the diffusion of oxyhemoglobin is the mechanism by which steady-state oxygen transport is facilitated.


Diffusivity measurements of human methemoglobin. Experimental measurements of the diffusion coefficient of human methemoglobin were made at 25 degrees C with a modified Stokes diaphragm diffusion cell. A Millipore filter was used in place of the ordinary fritted disc to facilitate rapid achievement of steady state in the diaphragm. Methemoglobin concentrations varied from approximately 5 g/100 ml to 30 g/100 ml. The diffusion coefficient in this range decreased from 7.5 x 10(-7) cm(2)/sec to 1.6 x 10(-7) cm(2)/sec.


The effect of size of red cells on the kinetics of their oxygen uptake. Using a double-beam stopped-flow apparatus estimations were made of the velocity constant for the initial uptake of oxygen by fully reduced erythrocytes (k'(c)). Mammalian cells were studied with volumes varying from 20 micro(3) (goat) to 90 micro(3) (man), as were bullfrog cells (680 micro(3)). Measurements were made under physiological conditions of pH, P(CO2), and temperature. In man k'(c) was 80 mM(-1) sec(-1) and in other species smaller cells generally had a greater value for k'(c) than did the larger cells. In the goat it was 1.8 times as great as the human value; in the bullfrog it was only one-fifth as great. These differences could not be accounted for by interspecific differences in hemoglobin kinetics. The differences probably represent a true effect of size conferring some biological advantage on the species with the smaller cells. The cell membrane offered resistance to oxygen passage. Using the usual red cell model of an infinite sheet of reduced hemoglobin, membrane permeability appeared to differ among mammals. If, as is likely, the effective cell halfthickness differs among mammals, actual membrane permeability differences may be less. A method for measurement of oxygen saturation of dilute cell suspensions is also described.


Studies on the in vitro interaction of electrical stimulation and Ca++ movement in sarcoplasmic reticulum. Sarcoplasmic reticulum fragments (S.R.F.) were isolated from skeletal and heart muscles. These fragments were found to take up Ca(++) very actively from media. When monophasic square waves were passed through the S.R.F. suspension, the Ca(++) uptake by S.R.F. was decreased. When the suspension was stimulated electrically after the Ca(++) was taken up by S.R.F., the initiation and the cessation of the stimulation were followed by the release and re-uptake of Ca(++) by S.R.F., respectively. The degree of inhibition of the Ca(++) uptake as well as of the Ca(++) release by electrical stimulation was dependent on the voltage and the frequency of stimulation. The presence of inorganic phosphate or oxalate modified the influence of electrical stimulation on the release and the uptake of Ca(++) by S.R.F. Attempts were made to observe the release of Ca(++) by electrical stimulation from unfractionated sarcoplasmic reticulum remaining in myofibers, and the interaction of the released Ca(++) with myofibrils in vitro. For this purpose, the glycerol-extracted fiber was selected as a muscle model, since it contains both sarcoplasmic reticulum and myofibrils. It was found that electrical stimulation of skeletal and heart glycerol-extracted fibers resulted in the contraction of fibers. It appeared that the contraction of glycerol fibers by electrical stimulation was caused by the Ca(++) release from sarcoplasmic reticulum by stimulation.


The cellular transport of calcium in rat liver. The bidirectional transport of calcium in rat liver was studied using slices labeled with Ca(47) in a closed two compartment system. Steady-state conditions were observed with influx and efflux transfer coefficients of 0.070 and 0.018 per minute, respectively. The rapidly exchanging cell fraction of calcium existed at a concentration three times higher than the average cell concentration of calcium and occupied cell loci comprising less than 25% of the cell mass, suggesting that calcium associated with the cell membranes, nuclei, and mitochondria participated in the rapidly exchanging fraction. At pH 7.4 and 377deg;C, the influx transfer coefficient was 25% above the steady-state condition and accumulation of calcium by the slices occurred. Studies of the effects of varied physical and chemical conditions revealed that the influx transfer coefficient was increased by elevated pH, strontium, certain metabolic inhibitors, and 2 mM concentrations of cyclic adenosinemonophosphate and adenosinetriphosphate. The influx transfer coefficient was decreased by reduced temperature, decreased pH, magnesium, and 10 mM adenosinetriphosphate. The efflux transfer coefficient was increased by elevated pH, strontium, iodoacetate, and adenosinetriphosphate, and was decreased by reduced temperature and by N-ethylmaleimide. These data support the thesis that cell transport of calcium is accomplished by the attachment of calcium atoms to the cell surface and transport through the plasma membrane bound to either specific carriers or to membrane constituents. Conditions which change the affinities, capacities, and mobilities of plasma membrane ligands that bind calcium or cause extracellular chelation of calcium are capable of altering the rate of calcium transport.


Structure of the red fluorescence band in chloroplasts. Using Weber's method of "matrix analysis" for the estimation of the number of fluorescent species contributing to the emission of a sample, it is shown that the fluorescence(1) band in spinach chloroplast fragments at room temperature originates in two species of chlorophyll a. Emission spectra obtained upon excitation with different wavelengths of light (preferentially absorbed in chlorophyll a or b) are presented. Upon cooling to - 196 degrees C, the fluorescence efficiency increases about twentyfold. Two additional bands, that now appear at 696 and 735 mmicro, suggest the participation of four molecular species. Emission spectra observed at different concentrations of chloroplast fragments with excitation in chlorophyll a and b and excitation spectra for different concentrations of chloroplast fragments and measurements at 685 and 760 mmicro are presented. Two of the four emission bands may belong to pigment system I and two to system II. The 685, 696, and 738 mmicro bands respond differently to temperature changes. In the -196 degrees C to -150 degrees C range, the intensity of the 685 mmicro band remains constant, and that of the 696 mmicro band decreases twice as fast as that of the 738 mmicro band.


The ionic dependence of cardiac excitability and contractility. In contrast to the large volume of data supporting the dependence of cardiac excitability and phasic contractility on external Na, Van der Kloot and Rubin (1962) and Singh (1962) have reported the persistence of both electrical and phasic mechanical activity in frog atrial and ventricular preparations soaked in isotonic sucrose solutions. The acute ionic dependence of excitability and contractility in small frog atrial trabeculae has been investigated with the conclusion that excitability and phasic contractions may continue for extended periods of time in sucrose media if the extracellular ionic concentrations remain above 2% of normal. This behavior is attributed to the slow exchange properties of the cell surfaces of the frog cardiac trabeculae and the antagonistic effects of Na, K, and Ca ions on both membrane excitability and fiber contractility.


Effects of the intracellular Ca ion concentration upon the excitability of the muscle fiber membrane of a barnacle. The membrane excitability and contraction were examined in single barnacle muscle fibers with different internal Ca(++) concentrations by using buffer solutions made up with EGTA and Ca-gluconate in various proportions. During the passage of dc currents the membrane shows all-or-none spike potentials for internal Ca(++) concentrations below about 8 x 10(-8)M, oscillatory potential changes in the range between 8 x 10(-8) to 5 x 10(-7)M, but neither oscillatory nor spike potentials were seen for concentrations above 5 x 10(-7)M. All-or-none spike potentials were suppressed when the internal Mg(++) concentration exceeded 5 mM. The suppression threshold of the internal Ca(++) concentration for the Sr spike is much higher than that for the Ca spike. The threshold concentration of internal Ca(++) for contraction was about 8 x 10(-7)M.


Calcium, magnesium, and local anesthesia.


Differences in Na and Ca spikes as examined by application of tetrodotoxin, procaine, and manganese ions. The effects of tetrodotoxin, procaine, and manganese ions were examined on the Ca spike of the barnacle muscle fiber injected with Ca-binding agent as well as on the action potential of the ventricular muscle fiber of the frog heart. Although tetrodotoxin and procaine very effectively suppress the "Na spike" of other tissues, no suppressing effects are found on "Ca spike" of the barnacle fiber, while the initiation of the Ca spike is competitively inhibited by manganese ions. The initial rate of rise of the ventricular action potential is suppressed by tetrodotoxin and procaine but the plateau phase of the action potential is little affected. In contrast the suppressing effect of manganese ions is mainly on the plateau phase. The results suggest that the plateau phase of the ventricular action potential is related to the conductance increase in the membrane to Ca ions even though Na conductance change may also contribute to the plateau.


Studies on ion accumulation in muscle cells. A comparison is made between the quantitative predictions of equilibrium ionic distribution in living cells according to the membrane theory (Donnan equilibrium) and according to the association-induction hypothesis. This comparison shows that both theories predict competitive effects of one permeant ion on the equilibrium concentration of another permeant ion; but within the limit of experimental accuracy only the association-induction model predicts quantitatively significant specific competition of one specified ion with the accumulation of another specified ion. The equilibrium distributions of K(+), Rb(+), and Cs(+) ions in frog sartorius muscle were studied and quantitatively significant specific competition was demonstrated; these results favor the association-induction hypothesis (adsorption on cell proteins and protein complexes and partial exclusion from cell water). Based on this model we estimated that at 257deg;C, the apparent association constants for K(+), Rb(+), and Cs(+) ion are 665, 756, and 488 (mole/liter)(-1). We found that the total concentration of adsorption sites (no less than 240 mmole/kg of fresh cells) agrees with the analytically determined concentrations of beta- and gamma-carboxyl groups of muscle cell proteins (260 to 288 mmole/kg).


Tuberculous endometritis. A clinicopathological study of 120 cases.


Haemoglobins E and K and thalassemia in an Indian family with evidence of interaction between haemoglobin E and thalassaemia.


Dielectric dispersion of deoxyribonucleic acid. II.


Spin-free quantum chemistry. 3. Bond functions and the pauling rules.


Practice improvement. VI. Office and paper work.


Thyroid antibodies in euthyroid subjects after iodine-131 therapy.


Nephrocalcinosis in the white rat. I. The nephrocalcinogenic diet of Gilbert and Gillman.


Nineteenth World Health Assembly. 2.

Nineteenth World Health Assembly. 2.


Towards an extended medical research programme.


Malaria eradication in 1965.

Malaria eradication in 1965.


Health statistics in national and local health services.


Effects of griseofulvin in mycotic infections of the scalp.


Occupational health education in agriculture.


Biochemical and EEG studies in phenylketonuric children during phenylalanine tolerance testc.


Increased tolerance to cerebral anoxia by pentobarbital.


Effect of sympathomimetic amines on canine coronary arteriovenous differences of glucose and non-esterified fatty acids.


Distribution of radioactivity in the tissues and excretory products of rats and rabbits following administration of C-14-Hygroton.


Hypertensive retionopathy in pheochromocytoma.


A comparison between tonography and suction cup decay.


Leukemic infiltrates in the iris. Successful treatment of secondary glaucoma with x-irradiation.


Visual field defects in giant suprasellar aneurysms of internal carotid. Report of three cases.


Cryolysis of adhesion of anterior hyaloid membrane to corneal endothelium after uncomplicated cataract extraction.


The cerebro-ocular effects of carbon dioxide poisoning.


Congenital melanoma of the anterior uvea.


Treatment of a presumed case of sympathetic ophthalmia with methotrexate.


Ocular effects of radiation and photocoagulation. A study of 100 globes with retinoblastoma, some of which were treated prior to enucleation.


The contribution of personality theories to criminological research: socio-psychological aspects and general methodological problems.


Clinical experience with the Margulies intrauterine contraceptive device. There has been renewed interest in recent years in the use of intrauterine devices for contraception. The Margulies intrauterine device was inserted in 303 patients. Of 301 patients subsequently evaluated, 24 expelled the device spontaneously; in 21 others the device was removed for various reasons. No pregnancies occurred in the first 920 patient-months. There were no serious complications in the patients using the coil. From this experience we estimate that not more than 80% of patients will accept this technique. Intrauterine contraceptive devices are, however, a satisfactory addition to the various methods of birth control.


Ankylosing spondylitis: a late re-evaluation of 92 cases. Ninety-two patients who satisfied the criteria proposed by Kellgren for the diagnosis of ankylosing spondylitis were re-evaluated by clinical, radiological and laboratory parameters after an average length of illness of 18.7 years. The following associated clinical lesions were studied: aortic insufficiency 8%, heart block 3%, iritis 11%, and other associated lesions. Long-term effects of x-ray therapy were evaluated by comparing irradiated and non-irradiated patients; no significant difference was noted in the clinical course of these two treatment groups. On serum protein electrophoresis no characteristic dysproteinemia was demonstrated; in no instance was there a marked hypergammaglobulinemia. Test results for rheumatoid factor, antinuclear factor and antithyroglobulin were all within the range expected for a normal population. In addition to bilateral sacroiliitis, several other characteristic radiological lesions, such as anterior spondylitis, were present in a high percentage of cases. It is suggested that the diagnostic criteria proposed by Kellgren, although useful, should be enlarged and refined.


Education and Rorschach intelligence factors of the Harijans.


Serial electrocardiograms recorded on one subject over a period of 42 years (1923-65). A LONGITUDINAL STUDY OF THE RANGE OF NORMAL IN THE ELECTROCARDIOGRAM WAS CARRIED OUT, USING THE AUTHOR AS THE SUBJECT: 18 records were made in the course of 42 years (1923-1965). Only minor differences were demonstrated which are believed to represent differences in posture or in relation to meals, because the electrocardiograms were not recorded under standard basal conditions. The QRS was wider in the precordial than in the limb leads. The amplitude of T-waves varied within a range of 1-11.5 mv.


Reaction time as a measure of comprehension of the effects produced by rotation on objects.


The existence of a monosynaptic reflex arc in the spinal cord of the frog.


Intracellularly recorded responses of the cerebellar Purkinje cells.


Potentials evoked by stimulation of the medial forebrain bundle in rats.


Boutons terminaux and tri-ortho-cresyl phosphate neurotoxicity.


Evoked potentials from the visual system in hypothermic hibernators and nonhibernators.


Effect of visual deprivation during postnatal maturation on the electroencephalogram of the cat.


Amplitude of evoked potentials as a function of slow presenting rates of repetitive auditory stimulation.


Responsiveness to sensory stimulation of units in the superior colliculus and subjacent tectotegmental regions of the rabbit.


Issues and problems in community psychiatry.


Student companions for chronically ill patients.


Research programs in the major mental illnesses. I.


Reality-oriented group therapy.

Reality-oriented group therapy.


Research programs in the major mental illnesses. II.


Interagency mental health education.

Interagency mental health education.


Working with the parents of disturbed children.


Psychiatric training for interns.

Psychiatric training for interns.


Early strategies in treating alcoholics.


Teaching illiterate patients to read.

Teaching illiterate patients to read.


The allantoins.

The allantoins.


The wooden sole shoe in podiatry practice.


Bone clamp for forefoot surgery.

Bone clamp for forefoot surgery.


Sesamoidectomy clamp.

Sesamoidectomy clamp.


Clinical evaluation on plantar keratosis using the Dermo-Jet.


Fracture of the tuberosity of the calcaneus.


Gouty arthritis.

Gouty arthritis.


Keratosis palmaris and plantaris. A case report.


Vibrational spectrum of hydrazine-d4 and Raman study of hydrogen bonding in hydrazine.


The nocturnal behaviour of slugs.

The nocturnal behaviour of slugs.


The "carbon dioxide response curve" for chronic hypercapnia in man.


The diagnostic importance of faecal porphyrins in the differentiation of the porphyrias. 3. South African genetic porphyria (variegcte porphyria)--the acute attack.


Effect of antibiotic therapy on gluten-sensitive enteropathy.


Incidence and severity of nutritional deficiency states in chronic exocrine pancreatic insufficency: comparison with nontropical sprue.


Pseudotumors of the stomach.

Pseudotumors of the stomach.


Histopathology of the upper small intestines in typhoid fever. Biopsy study of experimental disease in man.


Clinical gastric "freezing".

Clinical gastric "freezing".


The malignant carcinoid syndrome. Report of 5 cases.


Free perforation in regional enteritis. Report of 2 cases and review of the literature.


Jaundice and enlargement of the gallbladder: a diagnostic problem. Report of 2 cases.


Sequelae of the LD/50 x-ray exposure of the pre-implantation mouse embryo: days 0.0 to 5.0.


The effect of hypophysectomy on sodium metabolism of the gill and kidney of Fundulus kansae.


Uptake of organic material by aquatic invertebrates. IV. The influence of salinity on the uptake of amino acids by the brittle star, Ophiactis arenosa.


Mechanical forces as a cause of cellular damage by freezing and thawing.


Correlation of lysosomal activity and ingestion by the mantle epithelium.


Quantitative aspects of brown adipose tissue thermogenesis during arousal from hibernation.


Determination of the in vivo carbon dioxide titration curve of anaesthetized man.


Increase of creatine kinase activity in serum as sign of muscular injury caused by intermittently administred suxamethonium during halothane anaesthesia.


Propranolol (inderal) during halothane anaesthesia.


Muscle pain following administration of suxamethonium: the aetiological role of muscular fitness.


Centralized monitoring.

Centralized monitoring.


Stimulation of laryngospasm in the cat by volatile anaesthetics. Preliminary communication.


Heat clearance: a convenient method of estimating peripheral blood flow?


Retinal angiopathy in the imino-dipropionitrile-treated alloxan-diabetic rat.


Cardiac function in early renal hypertension: observations with a rat heart/lung preparation.


The development of permeability activity by undiluted plasma on exposure to glass.


Bacterial growth in an in vitro system simulating conditions in the urinary bladder.


Variations in the amino acid composition of aortic elastin from different species.


The isolation and partial characterisation of serum thrombotic accelerator (STA).


Serum lipids and lipoproteins in human pregnancy.


A comparison between the amounts of As, Au, Br, Cu, Fe, Mo, Se and Zn in normal and uraemic human whole blood by means of neutron activation analysis.


Sites of iodide entry into and absorption from the gut lumen and their relevance to the resin-[131-I]human serum albumin technique for investigation of protein-losing enteropathy.


The estimation of some important anticonvulsant drugs in serum.


Isoenzymes of creatine phosphokinase in tissue extracts and in normal and pathological sera.


Determination of free nicotinic acid in blood plasma.


A specific method for serum lipase determination.


Improved method for measuring galactose-I-phosphate uridyl transferase activity of erythrocytes.


Isolation of serotonin-O-sulfate from human urine.


Urea synthesis in the liver of the hypothyroid rat.


The use of homocysteine in the estimation of ascorbic acid in urine.


New micro test for vitamin A.

New micro test for vitamin A.


A densitometric method for the quantitative determination of protein fractions after agar gel electrophoresis.


The fatty acid composition of infiltrating fat in muscle from a case of muscular dystrophy.


The synthesis of thymolphthalein monophosphate, a new substrate for alkaline phosphatase.


Quantitation of thin-layer chromatograms with a paper strip densitometer.


A simplified AutoAnalyzer procedure for the determination of serum alkaline phosphatase activity.


Improved separation of the alpha-beta-esterases in human serum by electrophoresis on starch gel.


The determination of nicotinuric acid by means of the azlactone reaction.


The use of paper electrophoresis for the routine identification of urinary proteins in the dog.


The adolescent.

The adolescent.


Thiamine deficiency and beriberi heart disease.


A community-oriented rehabilitation center.


Toxicity--a frequent complication of digitalis therapy.


Developing and maintaining adult physical fitness through swimming. (A field study of a husband and wife, both full-time working medical doctors at a country club pool).


Asymmetries of growth in the pelvis and legs of growing children--a preliminary report.


Strength recovery from isometric fatigue observed during and after circulatory occlusion.


Post-gastrectomy steatorrhoea due to intestinal lactase deficiency.


The place of immunotherapy in the management of extensive burns.


The use of instant ice for prevention of blisters on the hands.


Some problems concerning the physiology and morphology of the motor analyzer.


The role of visual cues in perseverative behaviour of the rat.


The physical in mental alertness.

The physical in mental alertness.


Fronto-hypothalamic control over food-reinforced conditioned-reflex performance and differential inhibition in rabbits.


Changes of the background noise intensity and the bar-pressing response rate.


Scopolamine induced changes of brain acetylcholine and EEG pattern in cats with complete pontine transection.


Contribution to the ethology of Leptothorax acervorum (Hymenoptera: Formicidae).


Cortical D.C. potential changes associated with spontaneous sleep in cat.


Impulse activity in the crayfish stretch receptor neuron.


Responses of visual cortex to transcallosal and geniculate stimulations during sleep and wakefulness.


The reaction of beta-propiolactone with inosine 5'-phosphate. The preparation of N-(5-amino-I-beta-D-ribofuranosyl-imidazol-4-carbonyl)-beta-alanine 5-phosphate.


Fractionation of amino acid-specific s-RNA from silkgland by methylated albumin column chromatography.


Ribonucleic acid biosynthesis in methylcholanthrene-treated rats.


Structural requirements for the binding of ethidium to nucleic acids.


The subunits and structural ribonucleic acids of Jensen sarcoma ribosomes.


Ribosomal cistrons and the nucleolar organizer.


Deoxyribonucleic acid and the synthesis of protein in plant mitochondria. IV.


Base composition of messenger RNA from rabbit reticulocytes.


Preparation of tripeptydil-sRNA and its stability towards alkaline hydrolysis and hydroxylaminolysis.


Binding of s-RNA to rat-liver polysomes during protein synthesis.


Succinylation of rat-liver polysomes.

Succinylation of rat-liver polysomes.


A method for the preparation of mammalian deoxyribonucleic acid.


The chromatographic separation of ribonucleic acids.


A localized stimulation of lens protein synthesis by actinomycin D.


Urological aspects of hydatid disease.

Urological aspects of hydatid disease.


Carbuncle of the kidney.

Carbuncle of the kidney.


The diagnosis of ureteric tumours.

The diagnosis of ureteric tumours.


The urinary excretion of calcium in experimental hydronephrosis.


Colonic irradiaton in hyperchloraemic acidosis following urinary diversion in dogs.


The radio-isotope renogram in the non-functioning kidney.


Quantitative bacteriology of urinary infection.


Exstrophy of the cloaca.

Exstrophy of the cloaca.


A simple irrigating catheter.

A simple irrigating catheter.


Aspects of ionic regulation in certain terrestrial pulmonata.


The exchange of radioactive cations by somatic and cardiac muscles of the crayfish.


Seasonal oxidative phosphorylation by turtle heart mitochondria.


Gluconeogenesis in kidney cortex slices from cold-exposed rats and hamsters.


In vivo and in vitro uptake and distribution of C14-labeled glucose by Hymenolepis diminuta.


The biosynthesis of the emulsifiers of the crab Cancer pagurus L.


Innervation and control of a molluscan (Tapes) heart.


Possibilities of biochemical taxonomy of bats using hemoglobin, lactate dehydrogenase, esterases and other proteins.


The effect of drugs on the alimentary canal of the African migratory locust Locusta migratoria.


Comparative study of the mode of action of glycosidases of the gut of certain hemipterous insects.


Carbamoyl phosphate synthetase in the Elasmobranchii: osmoregulatory function and evolutionary implications.


The synthesis of acetyl phosphate by homogenates of elasmobranch liver.


Comparative metabolic fractionation of carotenoids in three flamingo species.


Absorption of fluid from isolated intestine of the toadfish, Opsanus tau.


Metamorphosis and gene action--I. Electrophoresis of dehydrogenases, esterases, phosphatases, hemoglobins and other soluble proteins of tadpole and adult bullfrogs.


Oxygen uptake by Trypanosoma lewisi complex cells. 3. C isolate.


Species differences in the intestinal transport of p-aminobenzoic acid.


Separation and properties of subcellular particles associated with 5-hydroxytryptamine, with acetylcholine and with an unidentified cardio-excitatory substance from Mercenaria nervous tissue.


Regulation of rectal movements in Tapes watlingi.


Chromatophores and permeability characteristics of frog skin.


Comparative biochemical studies of milks. 3. Immunoelectrophoretic comparisons of milk proteins of the Artiodactyla.


The excreta of spiders.

The excreta of spiders.


The energy relations of Carassius auratus L. II. The effect of food, crowding and darkness on heat production.


Increased digitalis toxicity associated with impaired renal function.


Thrombolytic therapy of recent myocardial infarction. I. Introduction, plan of trial, general clinical results.


An unusual form of intestinal obstruction after partial gastrectomy.


Occlusion of the retinal arteries.

Occlusion of the retinal arteries.


New aspects of diverticulitis of the colon.


Isolation and characterization of fractions of Mycoplasma pneumoniae. I. Chemical and chromatographic separation. Prescott, B. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.), O. Sobeslavsky, G. Caldes, and R. M. Chanock. Isolation and characterization of fractions of Mycoplasma pneumoniae. I. Chemical and chromatographic separation. J. Bacteriol. 91:2117-2125. 1966.-Fractionation of Mycoplasma pneumoniae, cultured on a beef heart infusion-horse serum-yeast extract medium, was carried out by chemical and chromatographic procedures. The chemical method yielded eight fractions consisting of lipid, carbohydrates, and proteins. Four protein-rich fractions were isolated by chromatographing a supernatant fluid of sonically treated organisms on Sephadex G-25. The 12 fractions were tested for serological and antigenic activity in vitro and in vivo. The lipid fraction was serologically active and the relative order of activity of the protein fractions appeared to depend on the amount of lipid present in the molecule. The highly serologically active Sephadex G-25 protein fraction 1 prepared chromatographically contained 15% lipid in the molecule, whereas the less serologically active protein fraction 2 prepared by chemical means contained 2% lipid. The acetone-extracted lipid fraction was chromatographed on thin-layer chromatography plates and found to consist of nine fractions. Serological activity was associated with only the first three spots above the origin. Lipid extracted from the protein fractions seemed to be similar to the acetone-extracted lipid from the sediment of the sonically treated organisms.


Allescheria boydii and Aspergillus fumigatus skin test antigens. May, Lewis K. (Woman's Medical College of Pennsylvania, Philadelphia), Ralph A. Knight, and H. William Harris. Allescheria boydii and Aspergillus fumigatus skin test antigens. J. Bacteriol. 91:2155-2157. 1966.-Protein and polysaccharide fractions were extracted from culture filtrates of Allescheria boydii and Aspergillus fumigatus by the methods of Seibert and of Heidelberger, and injected intradermally into guinea pigs previously infected with these fungi. The diameter of erythema and induration was determined at 8, 24, and 48 hr. The protein and polysaccharide antigens yielded specific skin reactions in homologously infected guinea pigs. Erythema appeared at 8 hr with both the protein and polysaccharide antigens. At this time, the polysaccharide skin tests showed erythema and a central blanched wheal. A similar wheal was not observed with the protein. The erythema of the polysaccharide reaction began fading at 24 hr, whereas the protein reaction remained unchanged through 48 hr with both antigens. In guinea pigs, the area of erythema was more constant and thus easier to measure than was induration.


Antigenic properties of the cell wall and other fractions of the yeast form of Histoplasma capsulatum. Pine, Leo (Communicable Disease Center, Atlanta, Ga.), Clarence J. Boone, and Dave McLaughlin. Antigenic properties of the cell wall and other fractions of the yeast form of Histoplasma capsulatum. J. Bacteriol. 91:2158-2168. 1966.-Yeast-form cells of Histoplasma capsulatum were fractionated in an attempt to obtain complement-fixing antigens with greater specificity than those of the currently used whole yeast form. No specific fraction was isolated. Rupture of the whole cell produced soluble and insoluble highly antigenic fractions. The soluble fractions rapidly lost antigenicity. Marked reduction of activity of some particulate fractions was also observed. The purified cell wall, stripped of its protein components, was antigenic, relatively stable, and demonstrated low cross-reactivity with heterologous sera. All fractions cross-reacted with sera from cases of North American blastomycosis to a greater degree than did the whole yeast-form antigen of H. capsulatum. The production of certain cellular fractions varied with the strains used. In complement-fixation tests, insignificant differences in specificity and antigenicity were found with whole-cell antigens from 13 H. capsulatum strains as well as with purified cell wall fractions prepared from 2 of these strains.


Endotoxin-induced hypersensitivity to histamine in mice. I. Contrasting effects of bacterial lipopolysaccharides and the classical histamine-sensitizing factor of Bordetella pertussis. Pieroni, Robert E. (Massachusetts Department of Public Health, Boston), Edward J. Broderick, and Leo Levine. Endotoxin-induced hypersensitivity to histamine in mice. I. Contrasting effects of bacterial lipopolysaccharides and the classical histamine-sensitizing factor of Bordetella pertussis. J. Bacteriol. 91:2169-2174. 1966.-The capacity of typhoid and possibly of pertussis endotoxins to induce histamine-shock susceptibility in some of the mice that survive graded doses of these endotoxins was confirmed. It was demonstrated, however, that pertussis endotoxin cannot be the main source of the typical histamine sensitization of pertussis vaccine. The following points are made. (i) With typhoid and pertussis endotoxins as inducers of histamine shock, no systematic relation between deaths and induction dose could be found, and 100% mortality could not be achieved. In contrast, with pertussis protective fraction as inducer, there was clear dose-response regression, with 100% mortality possible. (ii) The major part of the histamine-sensitizing activity of pertussis vaccine or its extracts was destroyed by trypsinization or by heating for 30 min at 100 C. These processes do not affect the histamine-sensitizing activity of the endotoxins. The implication for purified pertussis vaccine with high histamine-sensitization capacity is that endotoxin need not necessarily be present. The significance and possible mechanisms of action of endotoxin-induced histamine sensitivity are briefly discussed.


Leukocytes and interferon in the host response to viral infections. II. Enhanced interferon response of leukocytes from immune animals. Glasgow, Lowell A. (University of Rochester School of Medicine and Dentistry, Rochester, N.Y.). Leukocytes and interferon in the host response to viral infections. II. Enhanced interferon response of leukocytes from immune animals. J. Bacteriol. 91:2185-2191. 1966.-The production of interferon was studied under in vitro conditions in peritoneal leukocytes or macrophages from mice immunized with Chikungunya virus (CV). Cultures of leukocytes obtained from animals immune to CV produced 2- to 10-fold greater amounts of interferon when exposed to an inoculum of CV than similar cell preparations from nonimmune, control animals. The viral inhibitor produced in increased quantity by CV-immune leukocytes had the biological and biochemical properties of interferon. The enhanced interferon production was inhibited by actinomycin D. This response of immune leukocytes was specific, and was initiated only by CV; it was not observed in leukocytes from animals immunized against other viruses which were challenged with CV. The presence of neutralizing antibody could not be related to this response. The observed increase in interferon production was not dependent upon an enhanced virus uptake. The data are presented as a possible new dimension of the "immune response" and may suggest a mechanism for the phenomenon of "tissue immunity."


Suppression of amber and ochre rII mutants of bacteriophage T4 by streptomycin. Orias, E. (University of California, Santa Barbara), and T. K. Gartner. Suppression of amber and ochre rII mutants of bacteriophage T4 by streptomycin. J. Bacteriol. 91:2210-2215. 1966.-Streptomycin-induced suppression of amber and ochre rII mutants of phage T4 was studied in a streptomycin-sensitive strain of Escherichia coli and four nearly isogenic streptomycin-resistant derivatives of this strain, in the presence and in the absence of an ochre suppressor. Most of the 12 rII mutants tested were suppressed by streptomycin in the streptomycin-sensitive su(-) strain. This streptomycin-induced suppression in the su(-) strain was eliminated by the independent action of at least two of the four nonidentical mutations to streptomycin resistance. In two of the su(+)str-r strains, streptomycin markedly augmented the suppression caused by the ochre suppressor. In those su(-)str-r hosts in which significant streptomycin-induced suppression could be measured, the amber mutants were more suppressible than the ochre mutants.


Carbohydrate catabolism of Mima polymorpha. I. Supplemental energy from glucose added to a growth medium. Bell, Emily J. (University of Cincinnati, Cincinnati, Ohio), and Adrienne Marus. Carbohydrate catabolism of Mima polymorpha. I. Supplemental energy from glucose added to a growth medium. J. Bacteriol. 91:2223-2228. 1966.-Mima polymorpha, unable to grow in the presence of nonphosphorylated sugars as sole source of carbon and energy, grows rapidly and well in the presence of acetate, ethyl alcohol, short-chained fatty acids, and permeable intermediates of the tricarboxylic acid cycle. Chemical evidence indicates, however, a limited uptake of glucose. Further, glucose, although incapable of supporting growth as the sole source of carbon and energy, does increase both the rate of growth and the total cell crop when added as an ancillary nutrient to cells growing in a mineral salts medium which contains 0.03 m acetate as the carbon and energy source. A yield of energy from an abortive catabolism of glucose is hypothesized. In addition to the enhancement of growth rate and total cell crop, this hypothesis is supported by the facts that: (i) transport systems for the slightly permeable phosphorylated hexoses appear to be induced when glucose is incorporated into a medium capable of supporting growth and (ii) the rate of induction and the total activity of an inducible enzyme, isocitrate lyase E.C. 4.1.3.1., are markedly increased in the presence of supplemental glucose.


Carbohydrate catabolism of Mima polymorpha. II. Abortive catabolism of glucose. Marus, Adrienne (University of Cincinnati, Cincinnati, Ohio), and Emily J. Bell. Carbohydrate catabolism of Mima polymorpha. II. Abortive catabolism of glucose. J. Bacteriol. 91:2229-2236. 1966.-Mima polymorpha, unable to grow in the presence of glucose as a sole carbon and energy source, is able to obtain supplemental, utilizable energy from the partial catabolism of this substrate. Various enzymes of hexose catabolism have been assayed in this organism and in M. polymorpha M, a mutant obtained by ultraviolet irradiation. The parent strain contains a functional glucose dehydrogenase, glucose-6-phosphate dehydrogenase, diphosphofructoaldolase, and a 2-keto-3-deoxy-6-phosphogluconate aldolase, but is lacking in glucokinase, gluconokinase, 2-ketogluconokinase, and 6-phosphogluconate dehydrogenase. The enzymes present indicate partially functioning hexose diphosphate and Entner-Doudoroff pathways. The absence of kinases explains the inability of the strain to grow on glucose and an absence of 6-phosphogluconate dehydrogenase would indicate the absence of the complete pentose pathway. The mutant strain, M. polymorpha M, possesses, in addition to those enzymes produced by the wild type, both gluconokinase and 6-phosphogluconate dehydrogenase. The presence of the former explains the mutant's ability to grow on glucose, and the presence of the latter indicates a more complete pentose shunt. The supplemental energy obtained from partial glucose catabolism (to gluconic acid) may be obtained from a cytochrome-linked reaction of the glucose dehydrogenase.


Synthesis of malformin by an enzyme preparation from Aspergillus niger. Yukioka, M. (University of Hawaii, Honolulu), and T. Winnick. Synthesis of malformin by an enzyme preparation from Aspergillus niger. J. Bacteriol. 91:2237-2244. 1966.-An enzyme fraction derived from disrupted Aspergillus cells was able to utilize each of the component labeled amino acids of malformin for the synthesis of this cyclic pentapeptide. The process was stimulated by adenosine triphosphate, K(+), and Mg(++), and was optimal at approximately pH 8.5. It was not affected by inhibitors of protein synthesis (ribonuclease, chloramphenicol, puromycin). There is evidence that cysteine, rather than cystine, was incorporated into peptide linkage, so that the disulfide bridge of malformin was formed subsequently. Although only the d isomers of cysteine and leucine occur in the malformin molecule, the l, as well as the d form of these amino acids, was readily utilized by the enzyme preparation. As in the case of several other microbial peptide systems, it appears that the d enantiomorph can arise from the l isomer at an intermediate stage of polypeptide synthesis.


Long-chain fatty acid inhibition of growth of Streptococcus agalactiae in a chemically defined medium. Willett, Norman P. (University of Pennsylvania School of Veterinary Medicine, Kennett Square, Pa.), and Guy E. Morse. Long-chain fatty acid inhibition of growth of Streptococcus agalactiae in a chemically defined medium. J. Bacteriol. 91:2245-2250. 1966.-A chemically defined medium was developed for Streptococcus agalactiae which supported growth comparable to that obtained in complex medium. The effects of long-chain fatty acids on growth of the organisms were determined turbidimetrically. The order of activity of the fatty acids was dependent upon whether complete inhibition or median response (50% inhibition point) was used as a parameter of activity. When complete inhibition of growth was used as a measure, the degree of unsaturation of C(18) acids enhanced antimicrobial activity. However, when the median response was used as an index, this order was reversed. Increase in carbon chain from C(12) to C(18) did not correlate with either complete inhibition or median response points. Antimicrobial activity of unsaturated and saturated fatty acids was reversed by bovine serum albumin and other compounds, suggesting a bacteriostatic action.


Spore formation by Bacillus popilliae in liquid medium containing activated carbon. Haynes, W. C. (Northern Regional Research Laboratory, Peoria, Ill.), and Lenora J. Rhodes. Spore formation by Bacillus popilliae in liquid medium containing activated carbon. J. Bacteriol. 91:2270-2274. 1966.-Heretofore, it has not been found possible to evoke sporulation of Bacillus popilliae in liquid culture. We have discovered that sporulation will occur in tryptone-glucose-yeast extract broth shaken cultures if activated carbon (charcoal) is present during growth. The spores so engendered have survived drying in air and subsequent storage for several months as dry films and also in dry soil, sand, and a mixture of powdered calcium carbonate and talc. Furthermore, the longevity of cultures, even when spores are absent, is extended, in cultures containing activated carbon, to several weeks at a population of millions of cells per milliliter. This extension of life is the result of a marked change from rapid decline in numbers to an almost stationary population.


Pyruvate-carbon dioxide exchange reaction of Desulfovibrio desulfuricans. Suh, Byungse (University of Kansas, Lawrence), and J. M. Akagi. Pyruvate-carbon dioxide exchange reaction of Desulfovibrio desulfuricans. J. Bacteriol. 91:2281-2285. 1966.-The pyruvate-CO(2) exchange reaction, catalyzed by Desulfovibrio desulfuricans, required the presence of phosphate and coenzyme A. However, the requirement for phosphate disappeared when the concentration of coenzyme A was increased to a level of 3.8 x 10(-3)m. Passing crude extracts through a diethylaminoethyl-cellulose column and an Amberlite CG-50 ion-exchange column, to remove ferredoxin and cytochrome c(3), resulted in a marked decrease in exchange activity; full activity was restored by the addition of ferredoxin or cytochrome c(3). Fe(++) or Co(++) stimulated the exchange of CO(2) into pyruvate.


Host influence on the characteristics of Venezuelan equine encephalomyelitis virus. Heydrick, Fred P. (Fort Detrick, Frederick, Md.), Ralph F. Wachter, and Henry J. Hearn, Jr. Host influence on the characteristics of Venezuelan equine encephalomyelitis virus. J. Bacteriol. 91:2343-2348. 1966.-Alterations in plaque size, virulence, and lipid content of Venezuelan equine encephalomyelitis (VEE) virus were examined for possible interrelationships among these properties during 10 serial passages in embryonated eggs, suckling mice, chick embryo fibroblasts, and L cells. The chick embryo host maintained the same large-plaque and virulence properties of the virus through 10 passages as seen in the original seed. Passage of virus in either L cells or chick fibroblasts rapidly produced populations that were, in the main, intermediate with respect to plaque size and virulence. Passage of virus in suckling mouse brain yielded populations that were intermediate with respect to plaque size only. The nature of the lipid of the virus, in terms of the ratio of petroleum ether-soluble to -insoluble lipid, changed after only one passage in all systems except in chick embryos. Nine additional serial passages failed to enhance these changes in viral lipid, suggesting that the decrease in the large-plaque and virulence properties was not directly associated with changes in lipid content.


Preservation of dimethylsulfoxide-treated Anaplasma marginale with liquid nitrogen.


Availability of bases and nucleosides as precursors of nucleic acids in L cells and in the agent of meningopneumonitis. Tribby, Ilse I. E. (University of Chicago, Chicago, Ill.), and James W. Moulder. Availability of bases and nucleosides as precursors of nucleic acids in L cells and in the agent of meningopneumonitis. J. Bacteriol. 91:2362-2367. 1966.-Uninfected L cells and the meningopneumonitis agent propagated in L cells utilized exogenous adenine, guanine, and their ribonucleosides and deoxyribonucleosides for synthesis of both deoxyribonucleic acid (DNA) and ribonucleic acid. Cytosine, cytidine, and uridine were also incorporated into the nucleic acids of both host and parasite. L cells and the meningopneumonitis agent incorporated uracil, thymine, and deoxyuridine very poorly. L cells utilized thymidine and deoxycytidine almost exclusively for DNA synthesis, but the meningopneumonitis agent did not incorporate these nucleosides at all. Since the L cell had previously been shown to convert added thymidine to its nucleotides, mainly the triphosphate, it was concluded that the meningopneumonitis agent can utilize neither the thymidine nor the thymidine nucleotides of the L-cell pool, and that it can probably synthesize the thymidine triphosphate needed for DNA synthesis from the uridine of the L-cell pool.


Unattended laboratory operations--1. The safe operation of laboratory distillations over night.


Better obstetrical services.

Better obstetrical services.


A survey of unlimited reproduction.

A survey of unlimited reproduction.


Domiciliary deliveries in Dublin.

Domiciliary deliveries in Dublin.


Costs, expenses and estimates.

Costs, expenses and estimates.


The health of tomorrow's people: the demographic and sociological background.


Meniere's disease, serum cholesterol levels and atheroma.


Some aspects of non-toxic goitre.

Some aspects of non-toxic goitre.


Treatment and rehabilitation in the therapeutic community: a progress report.


The day centre in the geriatric rehabilitation programme in Fremantle hospital.


Diagnostic femoral arterial puncture.

Diagnostic femoral arterial puncture.


Two cases of lateral aberrant thyroid.

Two cases of lateral aberrant thyroid.


The growing edge of medicine. The value of nosology in psychiatry.


Cutaneous color sensitivity: explanation and demonstration.


Tensions in psychology between the methods of behaviorism and phenomenology.


Descriptive behaviorism versus cognitive theory in verbal operant conditioning.


Habituation and stimulus novelty: a model based on classical conditioning.


Optical texture versus retinal perspective: a reply to Flock.


Comments on "A power comparison of the F and L tests--I".


Mediation theory and the "Single-Stage" S-R model: different?


Zinc glucagon in idiopathic hypoglycemia of infancy.


Phlebotomy in acute glomerulonephritis.

Phlebotomy in acute glomerulonephritis.


Tape recorder for evaluation of coughs in children.


The angioosteohypertrophy syndrome.

The angioosteohypertrophy syndrome.


Early mental hospitals in Spain.

Early mental hospitals in Spain.


Psychiatric consultation education--1966.


Camping: an approach to releasing human potential in chronic mental patients.


The use of lithium carbonate in the treatment of manic psychoses.


Different ages of onset in varieties of phobia.


The conditioning treatment of nuresis.

The conditioning treatment of nuresis.


Schizophrenic children and maternal speech facility.


Leptospirae enzymatic properties on phospholipids.


Studies on the isolation and growth of Leptospira from surface waters.


Criteria of postvaccinal immunity in leptospirosis.


Leptospira icterohaemorrhagiae-infection of experimental animals with artificially decreased resistance.


Sociological theory and deafness: problems and prospects.


A study of the anticholinesterase and anticurare effects of some cholinesterase inhibitors.


ulmonary changes after extracorporeal circulation in dogs.


Observations on tacheal rauma following suction: an experimental study.


The blood sugar response to anaesthesia and surgery in  southern Indians.


Physics applied to anaesthesia. V: gases and vapours.


Subcutaneous emphysema, pneumomediastinum and pneumothorax.


Respiratory depression following the use of tacrine and suxamethonium. A case report.


A test of two types of halothane vaporizer.


Cleft lip and palate.

Cleft lip and palate.


Functional symptoms.

Functional symptoms.


Further experience with cloxacillin in the treatment of infections caused by penicillinase-producing staphylococci.


The value of glycodiazine ('Gondafon') for the elderly diabetic.


Idiopathic bowel rupture.

Idiopathic bowel rupture.


Pilonidal sinus of the umbilicus.

Pilonidal sinus of the umbilicus.


Pulmonary fat embolism.

Pulmonary fat embolism.


Toxic hepatitis following phenylbutazone therapy.


The Quebec hospital strike.

The Quebec hospital strike.


Some effects of Medicare on hospital financing in Saskatchewan.


Hospital accreditation: a program for the patient.


Current issues in health services.

Current issues in health services.


Fire at Yellowknife.

Fire at Yellowknife.


A 'first' for St. Boniface in cardiovascular investigation.


Nurses probe collective bargaining and automation.


Automation and its affect on nursing.

Automation and its affect on nursing.


Canada's gift.

Canada's gift.


Co-operation in primitive human societies.


Co-operation between human groups.

Co-operation between human groups.


A quantitative statement of the two-component hypothesis of gastric secretion.


Value of beta-glucurondase activity in gastric juice in the diagnosis of gastric carcinoma.


Dose-response curves of denervated atogenous and homotransplanted canine fundic pouches stimulated with purifiedastrin and histamine.


The effect of sham feeding on the secretion and motility of canine duodenal pouches.


Ulcerative proctitis: course and prognosis.


Primary carcinoma of the liver in infancy. Report of a case with review of the literature.


Tetanus neonatorum. A study of 112 cases.


Prophylactic immunizations.

Prophylactic immunizations.


Hypovolemic shock of hypoproteinemia. Report of a case treated with metaraminol infusion in a child.


Refractory shock.

Refractory shock.


Oral anti diabetic drugs.

Oral anti diabetic drugs.


The evolution of census consciousness and population data in mainland China. The formative stage--1911 A.D.--1949 A.D.


Vasectomy.

Vasectomy.


Anahormones of growth hormone, exophthalmic factor, melanophore-stimulating hormone, adrenocorticotropin and gonadotropin in experimental and clinical endocrinology.


Tumour-specific immunity against spontaneous rat tumours.


Cell contact and cell adhesion during tissue organization.


Comparative effects of DL-glyceraldehyde, 6-mercaptopurine, methotrexate and 5-fluorouracil on the Ehrlich ascites carcinoma in vivo.


Action of the fluorescent dye, acridine orange, on radiation-induced leukocytosis in mice.


The incidence of leukemia in the Lebanese population.


Managers' attitudes towrd how their pay is and should be determined.


Job satisfaction and turnover in a female clerical population.


Cognitive aspects of psychomotor performance The effects o performance goals on level of performance.


An effect of noise on the distribution of attention.


Prediction of leadership in a simulated industrial task.


Organizational conditions and behavior in 234 industrial manufacturing organizations.


Effects of practice on apttude scores.

Effects of practice on apttude scores.


Cartoon reaction scale with special reference to driving behavior.


Are Herzberg's motivators and hygienes unidimensional?


Increasing test validity by considering interitem correlations.


Compulsivity as a moderator variable: a replication and extension.


Prediction of collee achievement from the Edwards personal preference schedule using intellectual ability as a moderator.


Factor analysis of category and magnitude scales of a technical attribute.


Safety in the chemical laboratory. 28. Unattended laboratory operations--2. Running laboratory reactions under safe control.


On the melting of copolymeric DNA.

On the melting of copolymeric DNA.


Magneto-optical rotatory dispersion of porphyrins and phthalocyanines.


Surgical treatment of aortic stenosis.

Surgical treatment of aortic stenosis.


Radiologic seminar LI: the posterior fat pad sign.


What we cannot do alone.

What we cannot do alone.


Clinicopathological conference LXXVIII. Mississippi Baptist Hospital, Jackson, Mississippi.


The eosinophil: its significance.

The eosinophil: its significance.


Excretion of metabolites of 14C-pyrimidine-labeled thimine by the rat at different levels of thiamine intake.


Effects of methionne, menhaden oil and ethoxyquin on serum cholesterol of chicks.


Nutritional studies on hysterectomy-obtained SPF baby pigs fed infant formula products.


Lysine-arginine-electrolyte relationships in the rat.


Acetate metabolism in ruminant tissues.

Acetate metabolism in ruminant tissues.


Action of Amprolium on the thiamine content of rat tissues.


Effec of pyridoxine deficiency on the metabolism of linoleic acid in the rat.


Dietary and defaunation effects upon plasma amino acid concentrations in sheep.


An experimental study comparing the acute occlusion of the anterior descending and the left circumflex coronary arteries.


Pulmonary complications following perfusion of the lungs.


A quantitative determination of perfusion fibrinolysis.


Treatment of severe cardiogenic shock by diastolic augmentation after ligation and division of the left circumflex coronary artery in dogs.


Left heart bypass in left ventricular failure due to experimental coronary artery ligation.


Internal mammary-coronary artery anastomoses. A method utilizing Nakayama's instrument for small vessel anastomoses.


Evaluation of radical pericardiectomy for constrictive pericarditis. A clinical, hemodynamic, and electrocardiographic study of twenty cases.


Rupture of the aorta into the left lung (aortopulmonary fistula with lung hematoma formation). Report of a case of successful treatment by operation.


The use of valve prostheses in childhood.


Commissurotomy for mitral stenosis combined with pulmonary resection. Report of a case and review of the literature.


Cardiovascular studies in the exercising animal. Cardiac output, arterial pressure, cardiac work, and blood gas studies in the normal dog and the dog with heart block under maximal exercise methods and preliminary results.


Physiological studies and clinical experience in patients with synchronous and asynchronous pacemakers.


Surgical treatment of supravalvular aortic stenosis. Report of 16 cases and review of literature.


Post-traumatic acquired coarctation of the descending thoracic aorta.


The determination and enumeration of the ASSOCIATIVE microflora of edible emulsions. I. Mayonnaise, salad dressings and tomato ketchup.


The compound polarizer.

The compound polarizer.


A close-tolerance incubator.

A close-tolerance incubator.


The effect of context on the production of hostile associates to ambiguous verbal stimuli.


Some problems in the total care of retarded cerebral palsy patients in New South Wales.


Chloasma and oral contraceptives.

Chloasma and oral contraceptives.


Subarachnoid haemorrhage of undetermined aetiology.


An experimental analysis of the relative importance of pitch, quantity, and intensity as cues to phonemic distinctions in Southern Swedish.


Complement-fixing platelet antibodies in the serum of a pregnant woman suffering from transfusion reactions.


A disposable exchange transfusion and scalp transfusion set.


Studies concerning the retardation of clotting by a new process.


The amyotrophic lateral sclerosis of Guam.


Children in collectives.

Children in collectives.


The speech production and spoken language of the deaf.


The role of thyroid dysgenesis in non-goitrous cretinism and juvenile myxoedema.


Immediate verbal memory and linguistic sophistication in a group of six-year-old children.


Naming sequentially presented letters and words.


The measurement of duration of speech.

The measurement of duration of speech.


Cytodiagnosis and pathogenesis of lung tumors and experiments with influenza virus. Optical and electron microscopic studies.


Clinical experiences with ciclofarlutal.


Clinical trial of a new topical cutaneous scar-promoting agent.


Dyschondrosteosis.

Dyschondrosteosis.


The placenta. A multicategorical, interdisciplinary phenenon. (Borden Award addres).


Treatmentof congenital megacolon in 50 infants.


Phenylketonuria: a study of human bichemical genetics.


Transitory hypertension following urologic surgery in hildren.


Varying expression for salt losing in related patients with congenital adrenal hyperplasia.


The protective effect of polyvalent oil-adjuvant influenza vaccine in chdren.


Increasing pulmonary vascular resistance during infancy in association with ventricular septal defect.


Anatomical and functional aspects of the knee-joint.


Studies on hyaline membrane disease. IV Diagnostic and prognostic problems.


Internal derangement of the knee-joint.

Internal derangement of the knee-joint.


Osteochondritis dissecans of the knee.

Osteochondritis dissecans of the knee.


Quadricepsplasty.

Quadricepsplasty.


Recurrent dislocation of the patella.

Recurrent dislocation of the patella.


The causes of osteoarthritis of the knee.


The treatment of osteoarthritis of the knee.


Sleeping with a painful neck.

Sleeping with a painful neck.


The assessment of mitral valve lesions with cine levoangiocardiography.


New concepts in dextrocardia. Angiocardiographic considerations.


Oblique left ventriculography in endocardial cushion defect, grade 3.


Angiocardiographic findings in ventricular aneurysm due to arteriosclerotic myocardial infarction. Report of 11 cases.


Roentgen diagnosis of left ventricular aneurysm.


Roentgenographic anatomy of human coronary arteries.


Carbon dioxide cineangiocardiography in the diagnosis of pericardial disease.


Congenital coronary arterial fistula to a persistent left superior vena cava.


Anomalous pulmonary venous return, pulmonary sequestration, bronchial atresia, aplastic right upper lobe, pericardial defect and intrathoracic kidney. An unusual complex of congenital anomalies in one patient.


Coronary artery calcification. Its incidence and significance in patients over forty years of age.


Right aortic arch: plain film diagnosis and significance.


Kinking or buckling of the aorta. Case report with complication of aneurysm formation.


Roentgenologic findings in conditions of the ascending aorta simulating aortic valvular insufficiency.


Reflux aortography combined with the Valsalva maneuver in the diagnosis of abdominal aortic aneurysms.


Selective visceral and total abdominal arteriography via the left axillary artery in the older age group.


Two unusual cases of subclavian steal syndrome. Bilateral steal and steal secondary to tumor thrombus.


Development of collateral vessels in an acute occlusion of the common hepatic artery.


Portal venography by selective arterial catheterization.


Clinical used of selective external carotid arteriography.


Arterial stationary waves.

Arterial stationary waves.


A new instrument: controllable guide for angiography.


A curved-tip guide wire for thoracic and abdominal angiography.


Timing device for cineangiocardiography.


The floppy wire as an aid in arterial catheterization.