Bromism and epilepsy.

Bromism and epilepsy.


Determining the erythrocyte sedimentation rate of cattle.


FDA's new bureau of veterinary medicine.


Photomicrography--importance of the collector lens.


Design of a phase contrast time-lapse cinemicrographic unit.


Teratogenic effects of calcium salts on chick embryos.


Observations on some tumours found in two species of planaria--Dugesia etrusca and D. ilvana.


The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis.


Obstruction of the common iliac artery by the contracting uterus. I. Pressure patterns recorded at the site of compression.


The effects of erythropoietin on haem synthesis in mouse yolk sac and cultured foetal liver cells.


An observation on the contraceptive mechanism of intrauterine contraceptive devices.


Studies on fetal ECG informations in late pregnancy and parturition. II. The FECG configurations and fetal arrhythmias.


Intranasal oxytocin for the induction and stimulation of labor.


Studies on serum beta-N-acetylglucosaminidase in pregnancy.


The motoring offender as a social problem.


Problems of the long-term prisoner.

Problems of the long-term prisoner.


The Harben Lectures 1966. Implications for autoimmune disease in man of studies on NZB mice and their hybrids. 3. Genetics and pathogenesis of autoimmune disease.


The Harben Lectures 1966. Implications for autoimmune disease in man of studies on NZB mice and their hybrids. 2. Renal and thymic disease.


The Harben Lectures 1966. Implications for autoimmune disease in man of studies on NZB mice and their hybrids. 1. Autoimmune haemolytic anaemia.


Immunoelectrophoresis in chronic hepatic affections.


The factors that cause relapses in chronic evolutive polyarthritis.


A paradox in the perception of luminance gradients. I.


The importance of collative-affective and intensive arousal potential in stereoscopically induced perceptual conflict.


Binocular rivalry as a function of incongruity in meaning.


Properties of the Holley-Guilford 'G index of agreement' in R and Q factor analysis.


The immunoallergic significance of the perivascular cellular infiltrate in primary human demyelinating encephalomyelitis.


A reply to Philip Levy--in defense of the G index.


Treatment of certain dermatoses with natural mud extracts.


Decontamination of radioactive waters by coprecipitation with Ca(MnO4)2 and active earths.


Comments on factoring dichotomous score matrices.


The value of gastric mucosa biopsy in the diagnosis of chronic gastrites.


Psychotic disturbances in the surgical patient.


On the application of mathematical learning theories. I.


Device for the concomitant study of the action potential and fluorescence variations of the nerve.


Recalibration of the ozenous nasal cavity with a buccojugal pediculate flap.


On the application of mathematical learning theories. II.


Note on learning, contingency, and clinical experience.


Contribution to the study of infestation with Isospora belli in children.


A test of Hendin's hypotheses relating suicide in Scandinavia to child-rearing orientations.


In vitro metabolism of progesterone-4-14C by the adrenal gland of the Mongolian gerbil.


The treatment of menopause by folycysteine G.


Estrogen secretion, biosynthesis and metabolism: their relationship to the menstrual cycle.


Determination of testosterone by gas-liquid chromatography using an electron capture detector. I. Responses of halo-alkyl derivatives.


Urinary excretion of epitestosterone and testosterone in normal individuals and hirsute and virilized females.


Steroid hormone formation by the rat ovary. 3. Estrogen biosynthesis from acetate-1-14C.


Effects of 17-beta-estradiol on bone maturation in mice.


The preparation and biological activity of some 11-beta-hydroxypregna-1,4,8-trienes.


Phospholipids in the androgen stimulated sexual segment of the kidney of the Indian house lizard, Hemidactylus flaviviridis Rüppell.


The influence of mental activity and visual fixation upon caloric-induced nystagmus in normal subjects.


The use of hypnosis in audiologic assessment.


Epistaxis treated with epsilon-amino-n-caproic acid.


Factors affecting vestibular nystagmus in Coriolis stimulation.


On the sound pressure transformation by the head and auditory meatus of the cat.


Unilateral deafness in children.

Unilateral deafness in children.


Teddy-bear screening audiometry for babies.


Generalized allergic reactions in Trichinella-infected mice: the temporal association of host immunity and sensitivity to exogenous antigens.


Thiabendazole therapy of visceral larva migrans: a case report.


The influence of temperature on the biology of Biomphalaria pfeifferi (Krauss), an intermediate host of Schistosoma mansoni.


Observations on two South African bulinid species of the truncatus group (Gastropoda, Planorbidae).


Studies on the relative susceptibility of some lymnaeids to infection with Fasciola hepatica and F. gigantica and on the adaptation of Fasciola spp.


Studies on the vector of kala-azar in Kenya. V. The outbreak in Meru district.


Granuloma in the pouch of Douglas caused by Enterobius vermicularis.


The prevalence of antibodies against Toxoplasma in stray dogs in Paramaribo, Surinam, Dutch Guiana.


Drug responses of mepacrine- and primaquine-resistant strains of Plasmodium berghei Vincke and Lips, 1948.


Observations on cocoon formation, the pupal stage, and emergence of the adult of Simulium damnosum Theobald in Ghana.


Anaemia, parasitaemia, erythrophagocytosis, and haemagglutinins in Babesia rodhaini infection.


A rural sanitation project in Sabah (North Borneo).


The effect of x-irradiation on the survival of Liponyssus bacoti and on its susceptibility to infection with Litomosoides carinii.


The effect of water velocities on the infection of animals exposed to Schistosoma mansoni cercariae.


The effect of water velocities on the infection of Biomphalaria sudanica tanganyicensis exposed to different numbers of Schistosoma mansoni miracidia.


Host-parasite relationships in schistosomiasis. I. The effect of temperature on the infection of Biomphalaria sudanica tanganyicensis with Schistosoma mansoni miracidia and of laboratory mice with Schistosoma mansoni cercariae.


Host-parasite relationships in schistosomiasis. II. The effects of age and sex on the infection of mice and hamsters with cercariae of Schistosoma mansoni and of hamsters with cercariae of Schistosoma haematobium.


In vitro metabolism of atrial and ventricular myocardium: effect of ouabain.


In vitro metabolism of atrial and ventricular myocardium from normal and atropine treated dogs: effect of carbachol.


In vitro metabolism of atrial and ventricular myocardium from reserpine treated dogs: effect of ouabain.


The effect of altering the calcium concentration of the perfusing fluid on the isolated guinea pig kidney preparation.


Evidence for an intestinal inhibitor of villous motility.


Vascular changes during oxy- and thiobarbiturate perfusion modified by reserpine and iproniazid.


Toxicological properties of N,N-dimethyl-4-phenyl-4-(alpha, alpha, alpha-trifluoro-p-tolyl)-3-butenyl-amine hydrochloride (BS 7308).


Effect of lead acetate on serum calcium and phosphorus in rats.


The role of the adrenal medulla in the blood pressure response to carbon dioxide following hexamethonium.


Pharmacologic study of the relationship between the total and intrarenal blood flows.


Influence of sympathetic stimulation on segmental vascular resistance before and after adrenergic neuronal blockade.


The hypocalcemic effect of actinomycin D.


The effects of intracardiac and intravenous injections of hypertonic saline on pulmonary venous and systemic arterial pressures.


Studies of chloroplast development in Euglena. 13. Variation of ultraviolet sensitivity with extent of chloroplast development. Ultraviolet (UV) inactivation of green colony-forming ability of several different types of Euglena gracilis var. bacillaris was studied. The observed target numbers are not widely different, while the doses required to produce a single inactivation event (D(o)) vary with the type of cell used. In dark-grown cells adapting to the light in resting medium and in an X-ray-induced mutant, D(o) is proportional to the chlorophyll content of the cells. However, in hyperdeveloped cells which contain abnormally high amounts of chlorophyll, the correlation does not hold, suggesting that it is not chlorophyll per se which is responsible for the differences observed. D(o)'s of colony-forming ability (viability) of light-grown and dark-grown cells are found to differ by the same factor as those of green colony-forming ability. Stationary phase and exponential phase cells show a small difference in D(o) with no obvious difference in target multiplicity. The multiplicity of the various target curves has been re-evaluated by computer and found to be between 30 and 40.


Studies of chloroplast development in Euglena. XIV. Sequential interactions of ultraviolet light and photoreactivating light in green colony formation. Photoreactivation (PR) of green colony-forming ability in Euglena is pH-insensitive from pH 6.0 to 8.0 and temperature-sensitive with a maximum rate at 35 degrees C. There is no PR at 0 degrees C. The rate of PR varies with the growth stage of the cells; PR of exponential phase cells is slower than that of stationary phase cells. The reciprocity rule holds for PR over a 6-fold range of intensity. The shape of PR curves is a function of the UV dose; there appears to be a progressive increase in multiplicity until a limiting multiplicity is reached as indicated by the fact that curves for high doses are superposable. Dark-grown and light-grown cells give the same PR response for comparable UV doses. UV inactivation of cells which have been treated with UV and then with PR light shows that, if the PR dose is sufficiently large, the same UV-inactivation curve is obtained as for nonpretreated control cells. Doses of PR lower than the saturating dose produce UV-inactivation curves, the ultimate slopes of which are parallel to the slope of the control curve, but which show reduced multiplicity. The multiplicity of these curves increases with increasing PR dose. The UV inactivation of green colony-forming ability in Euglena is completely photoreactivable at the doses studied, in contrast with the UV inactivation of colony-forming ability, which occurs at considerably higher UV doses and behaves like most other photoreactivable systems, showing a photoreactivable sector of 0.32.


Limitations on the equivalent cardiac generator. This paper is a critical summary of the implications of potential theory in electrocardiography with particular attention to the "inverse problem." It is emphasized that potential measurements on the human torso serve to determine only the multipole coefficients of the heart sources and that no additional information is available. An interpretation of these coefficients with respect to the actual electrophysiological sources is considered further on the basis of distribution theory.


A model for the action of vinblastine in vivo. A model for the action of vinblastine (VLB) on cells multiplying exponentially in vivo with a generation time, T(G), has been derived. It is based on the assumption that cells attempting to pass through mitosis in the presence of VLB lose their proliferative capacity and that this lethal effect occurs only when the cells are exposed to a concentration of VLB which is above a critical value, C(k). The model leads to two predictions. First, that the percentage of cells surviving at any time after exposure to a dose, D, of VLB is 100% if D < D(k) and decreases to 0% after a time, T(G), following a dose D >/= D(k).2(T G/T1/2), where D(k) represents the dose of VLB required to produce the concentration C(k), and T(1/2) is the half-life of the VLB in vivo. Second, that the time, T(G), at which the percentage of cells surviving an exposure to VLB, at doses greater than D(k).2(U G/T1/2), decreases to zero should be equal to the generation time of the cells. Both of these predictions were confirmed experimentally which indicates that the model adequately explains the action of VLB in vivo.


The kinetics of osmotic transport through pores of molecular dimensions. This paper presents a theoretical analysis of the kinetics of osmotic transport across a semipermeable membrane. There is a thermodynamic connection between the rate of flow under a hydrostatic pressure difference and the rate of flow due to a difference in solute concentration on the two sides. One might therefore attempt to calculate the osmotic transport coefficient by applying Poiseuille's equation to the flow produced by a difference in hydrostatic pressure. Such a procedure is, however, inappropriate if the pores in the membrane are too small to allow molecules to "overtake." It then becomes necessary to perform a statistical calculation of the transport coefficient, and such a calculation is described in this paper. The resulting expression for the number of solvent molecules passing through a pore per second is J = m D(1) deltan(1)/l(2) where m is the number of solvent molecules in the pore, l is the length of the pore, D(1) is the self-diffusion coefficient of the solute, and deltan(1) the difference in solvent mole fraction on the two sides of the membrane. This equation is used for estimating the number of pores per unit area of the squid axon membrane; the result is 6 x 10(9) pores/cm(2).


Intestinal damage and water imbalance in gamma-irradiated larve of Bombyx mori.


Free and lipid-bound amino acids of human thrombocytes.


Experimental studies on the reduction of the abundance of mosquitoes by spiders. I. Intensity of spider predation on mosquitoes.


Hemoglobin, erythrocytes and hematocrit in the blood of some microtidae under laboratory conditions.


Studies on blood leukocytes of some microtidae under laboratory conditions.


Influence of (2-chloroethyl) trimethylammonium chloride (CCC) on photosynthetic activity and frost resistance of tomato plants.


On the relationship between the erythroagglutinating and mitogenic activities of phytohaemagglutinin.


Multiple, bilateral, intracranial, intracavernous and intradural carotid aneurysms.


Further studies on asynchronous firing and block of peripheral nerve conduction.


Wernicke-like syndrome with chronic meningitis. A clinical neuropathological study of a patient with cysticercosis.


The fine structure of the embryonic mouse neural tube with special reference to cytoplasmic microtubules.


Enzymatic activity of differentiating muscle fibers. I. Development of phosphorylase in muscles of the domestic fowl.


Basal and induced levels of tryptophan pyrrolase and tyrosine transaminase in the chick.


Physiological changes in the bloodstream of chick embryos exposed to teratogenic doses of hypoxia.


Autoradiographic studies of the synthesis of nuclear DNA in various tissues during leaf development of Xanthium pennsylvanicum.


A histological and biochemical study of hormone-dependent differentiation of mammary gland tissue in vitro.


L-Malate dehydrogenase activity and protein synthesis in sea urchin embryos.


The histochemical localization of hydroxysteroid dehydrogenase activity in the livers of various species.


Synthesis and antigenic properties of sugar-polypeptide conjugates.


Allergens from common rye grass pollen (Lolium perenne). I. Chemical composition and structure.


Freezing of lactic cultures.

Freezing of lactic cultures.


Somatic cell content variation in fraction-collected milk.


Vitamin E and linolenic acid content of hay as related to different drying conditions.


Crossbreeding dairy cattle. I. Some effects of crossbreeding on the birth weight and gestation period of dairy cattle.


Measurement of udder volume in live goats as an index of mammary growth and function.


Inactivation of nisin by pancreatin.

Inactivation of nisin by pancreatin.


Effective teaching in dairy science. An administrator's view of teaching.


Combined introductory animal science.

Combined introductory animal science.


Introductory course in animal sciences.

Introductory course in animal sciences.


National Dairy Advisory Committee--a progress report.


Factors affecting the absorption of riboflavin in man.


Analogs of tetrahydrofolic acid. 32. Hydrophobic bonding to dihydrofolic reductase IV. Inhibition by p-substituted benzoic and benzoyl-L-glutamic acids.


Analogs of tetrahydrofolic acid. 33. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acid.


Analogs of tetrahydrofolic acid 34. Hydrophobic bonding to dihydrofolic reductase VI. Mode of phenyl binding of some 6-arylpyrimidines.


Water-oil emulsions prepared by low pressure capillary homogenization I. Effects of emulsator and composition variables on mannide mono-oleate stabilized systems.


Water-oil emulsions prepared by low pressure capillary homogenization II. Stabilizing influence of inorganic electrolytes, secondary emulsifiers, and temperature.


Critical evaluation of the compactor.

Critical evaluation of the compactor.


Comparative study of selected disintegrating agents.


New approach to development and manufacture of enteric compression coatings.


Evaluation of amylose as a dry binder for direct compression.


New drugs in xanthine derivatives XXVI. Pyridylthioethyl derivatives of theobromine and theophylline, and products of their oxidation.


Oxygen flask method for iodine determination in thyroid protein.


Synthesis of certain 5-nitropyridine derivatives structurally related to some chemotherapeutic agents.


Synthesis of methylglyoxal-14C.

Synthesis of methylglyoxal-14C.


Separation and analysis of degradation products of tetracycline by gel filtration on Sephadex G-25.


Glossary of terms from the physiological and acoustic phonetic theories.


Synthesis of 1,2-diethyl-4-(2-hydroxyethyl)pyrazolidine.


Spontaneous recovery from stuttering.

Spontaneous recovery from stuttering.


Hearing-aid performance and hearing-aid selection.


Effects of very low frequency tones on auditory thresholds.


A physiological theory of phonetics.

A physiological theory of phonetics.


The elements of an acoustic phonetic theory.


Activation of the pituitary-adrenal axis during rapid eye movement sleep in man.


The effect of visible light on adenosine triphosphate solution.


Refillment of the catecholamine stores with 3,4-dihydroxyphenylalanine after depletion induced by inhibition of tyrosine-hydroxylase.


Sub-cellular distribution of disulfide-bound cystine in wound tissue proteins.


Atherogenic aspects of desmosterol metabolism caused by prolonged triparanol administration.


Incorporation of stearate-1-C14 and oleate-1-C14 into phosphatidyl choline and phosphatidyl ethanolamine of rat liver mitochondria.


Studies on glucose synthesis by rat liver and kidney cortex slices.


A 24-hour rhythm in the content of norepinephrine in the pineal and salivary glands of the rat.


The scanning electron microscope.

The scanning electron microscope.


Structural features of the chloroplast.

Structural features of the chloroplast.


Split brains and octopuses.

Split brains and octopuses.


Steroids. IV. /1/. Degradation of solasodine to 6-chloropregnadienolone acetate.


The synthesis of 6-alpha,16-beta-dimethyl-9-alpha,11-beta-dichloro-1,4-pregnadiene-17-alpha,21-diol-3,20-diones.


Corticosteroids in the human brain.

Corticosteroids in the human brain.


Conversion of 17-hydroxyprogesterone into 3-alpha,17-dihydroxypregn-4-en-20-one, 17,20-beta-dihydroxypregn-4-en-3-one and other substances by bovine adrenal perfusion 1.


16-alpha-hydroxylation of pregnenolone by human liver.


The in vitro metabolism of pregn-5-en-3-beta-OL-20-one by rat testicular tissue. Formation of delta-16-steroids.


The sulfuric acid induced fluorescence of androst-4-ene-11-beta, 17-alpha dihydroxy-3-oxo-17 carboxylic acid.


Blood groups and human genetics.

Blood groups and human genetics.


The early recognition of curable neurosurgical conditions.


Severity of Fallot's tetralogy and its relationship to electrocardiographic observations.


Idiopathic paroxysmal myoglobinuria.

Idiopathic paroxysmal myoglobinuria.


Neonatal gastric perforation with recovery.


Further cases of Hb Q-H disease (Hb Q-alpha thalassemia).


Fractionation of serum albumin and genetic control of two albumin fractions in pigs.


Selection for rate of development and gene arrangement frequencies in Drosophila persimilis. II. Fitness properties at equilibrium.


Allele specific determinants of homothallism in Saccharomyces lactis.


Studies on the inheritance of electrophoretic forms of transferrins, albumins, prealbumins and plasma esterases of horses.


Deposition of labeled beta-alanine in ebony and non-ebony Drosophila melanogaster with notes on other amino acids.


A recessively inherited electrophoretic variant of alkaline phosphatase in chicken serum.


The consequences of ingestion by man of real and simulated fallout.


Self absorption of x-rays by plutonium particles with special reference to plutonium in wound monitoring.


Equilibrium specific activity relationships in two-compartment exchange systems.


Thermal annealing effects on the thermoluminescence of LiF.


Evaluation of gamma-ray photopeaks.

Evaluation of gamma-ray photopeaks.


A continuous monitor for prompt detection of airborne plutonium.


A spectrometric method for measurement of low-level gamma exposure dose.


A technique for recoil fission fragment range measurements.


The mass of the tracheobronchial lymph glands.


Fast neutron flux pattern for a 14-MeV neutron generator.


A proportional detector pair for simultaneous alpha-beta counting.


A method for adding range and safety to GM survey meters.


Physiological norms in Indian adults. Statistical analyses of data on organ weight.


An automatic device for collecting dust-free precipitation.


A rapid and quantitative method for the detection of plutonium in urine.


Histochemical demonstration of ATP. Creatine phosphotransferase in rat skeletal muscle.


Generalized rates of transfer in open systems of pools in the steady state.


Sensory projections of somatic, auditory and visual origin to the cerebral cortex of the sloth Choloepus hoffmanni Peters).


The accessory optic system in the marsupial phalanger, Trichosurus vulpecula. An experimental degeneration study.


Treatment of urinary and intestinal bilharziasis with Ciba 32644-Ba (Ambilhar). A preliminary report.


Simplified computation of confidence intervals for relative potencies using Fieller's theorem.


Pharmacological studies of norphenyl hemicholinium 3.


Identification and differentiation of organic medicinal agents. 3. Amine-containing antiparkinson agents and newer muscle relaxants.


Fluorometric determination of acetylsalicylic acid and salicylic acid in blood.


Thyroxin-triiodothyronine concentrations in thryoid powders.


Effect of complex formation on drug absorption. 3. Concentration- and drug-dependent effect of a nonionic surfactant.


Direct spectrophotometric determination of salicylic acid, acetylsalicylic acid, salicylamide, caffeine, and phenacetin in tablets or powders.


Comparative absorption of micronized and nonmicronized medroxyprogesterone acetate in man.


Cholinergic anionic receptors. 3. Steric requirements for quaternary ammonium inhibitors of acetylcholinesterase II.


Automated assay for the antibiotic lincomycin.


Detection of in situ compound instability by two-dimensional thin-layer chromatography.


Suspended animation and resuscitation. A historical review in the light of experimental hypothermia.


Some observations on nonlogarithmic titration curves for the determination of dissociation constants and purity.


Driving under the influence of alcohol.

Driving under the influence of alcohol.


Identification of some barbiturates by paper and thin-layer chromatography.


Physicochemical and physiologic factors affecting the absorption of warfarin in man.


Analgesic and local anesthetic activity of dimethyl sulfoxide.


Cyclic methyldopa analogs as potential antihypertensive and antineoplastic agents.


Modified computer programs for determining eutectic temperatures.


Identity of viminalol acetate.

Identity of viminalol acetate.


New era at FDA.

New era at FDA.


2,4-diamino-6-substituted-5-(4-carbethoxyphenylazo) pyrimidines as irreversible inhibitors of folic acid reductase.


Science policy for Britain.

Science policy for Britain.


A good start.

A good start.


Foam fractionation of phenol.

Foam fractionation of phenol.


Structural specificity of alpha-chymotrypsin: polypeptide substrates.


Structure of acetylcholine and other substrates of cholinergic systems.


Sucrose permease of Proteus mirabilis.

Sucrose permease of Proteus mirabilis.


Proliferation of human lymphocytes in culture.


Haemoglobin Köln (beta-98 valine--methionine): an unstable protein causing inclusion-body anaemia.


Distribution of selenium in the tissues of the eye.


Dry thermal inactivation of trypsin and ribonuclease.


Influence of electric field on the capacity of phospholipid membranes.


Uptake of norepinephrine in periglomerular cells of the olfactory bulb of the mouse.


Alpha-methyldihydroxyphenylalanine and release of noradrenaline.


Lysosomes and gout.

Lysosomes and gout.


Carcinogenic action of N-methyl-N'-nitro-N-nitrosoguanidine.


Methaemoglobin formation by Mycoplasma gallisepticum: the role of hydrogen peroxide.


Selective uptake of an antibilharzial nitrothiazole compound by Schistosoma mansoni.


Infection of Culex fatigans with a microsporidian.


Liberation of 5-hydroxytryptamine in the brain stem of adrenalectomized rats after x-irradiation.


Effects of gamma radiation on freeze-dehydrated apples (Pyrus malus).


Disaccharidases and histology of duodenal mucosa in congenital lactose malabsorption.


Experiences with human growth hormone in pituitary dwarfism.


The oxygen cost of minor changes in heat balance of small newborn infants.


Pulmonary arterial pressures of newborn infants born with early and late clamping of the cord.


Incidence in infants and mortality from congenital malformations of the circulatory system.


Generalized histiocytic reticulo-endotheliosis and leuco-encephalopathy in childhood.


Chronic idiopathic jaundice (Dubin-Johnson's syndrome) in three sisters.


Achromobacter septicemia in a premature. Clinical and bacteriological aspects.


Congenital alkalosis with diarrhea.

Congenital alkalosis with diarrhea.


Primary cold injury in the newborn.

Primary cold injury in the newborn.


Erythema multiforme bullosum caused by 9-bromofluorene.


Leukoplakia of the conjunctiva. A complication of x-ray therapy for carcinoma of the eyelid.


The D-xylose tolerance test in patients with gluten-sensitive enteropathy and generalized dermatitis.


Trichorrhexis nodosa; in vitro reproduction.


Trichorrhexis nodosa. Clinical and investigative studies.


Group variation in reactivity to common contact allergens.


Frictional lichenoid eruption in children. Recurrent pityriasis of the elbows and knees.


Pachydermoperiostosis. Touraine-Solente-Golé syndrome.


Purpura fulminans associated with varicella.


Keratoma hereditaria mutilans (Vohwinkel). Differentiating features of conditions with constriction of digits.


Angiokeratoma corporis diffusum.

Angiokeratoma corporis diffusum.


Incontinentia pigmenti associated with subungual tumors.


Pityriasis rubra pilaris. Treatment with folic acid antagonists.


The corticosteroid reservoir. Lack of physiologic and therapeutic significance.


Hexachlorophene deposition in human stratum corneum. Enhancement by dimethylacetamide, dimethylsulfoxide, and methylethylether.


Percutaneous penetration of 14C hydrocortisone in man. II. Effect of certain bases and pretreatments.


The histochemistry of the human nail.

The histochemistry of the human nail.


Cheilitis granulomatosa.

Cheilitis granulomatosa.


Parapsoriasis--lymphoblastoma.

Parapsoriasis--lymphoblastoma.


Scleroderma with ulceration secondary to atypical mycobacteria.


Solid edema of face (??).

Solid edema of face (??).


Reiter's syndrome.

Reiter's syndrome.


Sarcoidosis simulating disseminated discoid lupus erythematosus.


Bullous pemphigoid with polymyositis and co-existing contact dermatitis.


Scleroderma treated with dextran 40 (Rheomacrodex).


A comparison of the properties of synthetic 1,5- and 1,3-diribosyluracils with the natural presumed 1,5-diribosyluracil.


Inhibition of protein synthesis in reticulocytes by antibiotics. I. Effects on polysomes.


Inhibition of protein synthesis in reticulocytes by antibiotics. II. The site of action of cycloheximide, streptovitacin A and pactamycin.


Initiation of haemoglobin polypeptide chains.


Synthesis of ribosomal RNA and of microsomal membranes in the renoprival kidney.


Complex-formation by protein and nucleic acid. I. Evidence for specific interaction between phi-X174 phage protein and phi-X174 phage deoxyribonucleic acid in vitro.


Enzymatic depolymerization during isolation and the sedimentation properties of microsomal rapidly-labelled ribonucleic acids.


Preparations and properties of deamino-deoxyribonucleic acid.


Intracellular location of double-stranded plant viral ribonucleic acid.


Isolation and fractionation of ribonucleic acid from the smooth endoplasmic reticulum of rat liver.


Inactivation of acceptor activity of sRNA by means of N-cyclohexyl, N'-beta (4-methylmorpholinium)ethyl carbodiimide p-toluene-sulphonate.


The effects of inbreeding on body weight and abdominal chaeta number in Drosophila melanogaster.


Sex-linkage at two loci affecting eye pigment in the mosquito Aedes aegypti (diptera: culicidae).


Some properties of ribosomes and RNA from the midguts of the silkworm, Bombyx mori.


Mode of action of neocarzinostatin: inhibition of DNA synthesis and degradation of DNA in Sarcina lutea.


Y-chromosome loss in transplanted testicular teratomas of mice.


Changing the chick's requirement of arginine by selection.


The relative mutability of the cnb loci in Hypomyces.


Poisson analysis on the distribution of x-ray induced crossovers in spermatocytes of Drosophila.


Distortion of sex ratio in populations of Aedes aegypti.


The psychopathology of mystical and religious conversion experiences in psychiatric patients. A phenomenological study. II.


Renal acid phosphatase: a biochemical study.


Evolution of the immune response. V. Electron microscopy of plasma cells and lymphoid tissue of the paddlefish.


An electron microscope study of the effects of bacterial endotoxin on the blood-vascular system.


Widely distributed necrotic arterial lesions induced in rabbits by experimental renal alterations. V. Light microscopic studies of early lesions of arterial, cardiac, and skeletal muscle.


Fine morphology of human juxtaglomerular cells in patients with benign essential hypertension.


The muscular pulmonary arterial branches in stillborn natives of high altitude.


Myocardial temperature changes in acute experimental infarction.


Amino-acid components in fossil calcified tissues.


Evidence for depolarization of the internal membrane system in activation of frog semitendinosus muscle.


Erythrocyte phosphogluconate dehydrogenase polymorphism.


A physiological method for determining the degree of meterological cooling.


Structural studies of pig heart malate dehydrogenase.


A molecular mechanism for enzymatic transamination.


Number of molecules of antibody required to promote phagocytosis of one bacterium.


Establishment of a standard 'Holloman' chimpanzee blood group panel and its application for immunogenetic studies.


Inhibition of radiation-induced leukaemia by the injection of haematopoietic tissue: a study of chimaerism.


Compression of human red cells during centrifuging.


Cell multiplication rates during development of the primitive cardiac tube in the chick embryo.


Pinguinain: a simple method for its crystallization.


Acetate and other carboxylic acids as precursors of ethylene.


2-Acetamidofluorene and 3-methylcholanthrene: differences in binding to rat liver deoxyribonucleic acid in vivo.


Induction of enzyme activity in pea tissues by animal hormones and by puromycin.


Proposed catalytic role for histidine in pyridine nucleotide-linked alcohol dehydrogenases.


Denervation and the electrogenesis of the sodium pump in frog skeletal muscle.


Transaminase deficiency in alcoholics and cases of peptic ulcer.


Actinomycin D and the regulation of apoferritin synthesis in rat liver.


Demonstration of endogenous pyrogen in afebrile rabbits.


Growth hormone secretion in response to stress in man.


Inhibition of ribonucleic acid synthesis in mouse skin by actinomycin D and 7,12-dimethylbenz[alpha]anthracene.


Antibody production by single spleen cells: a comparative study of the cluster and agar-plaque formation.


Effect of alimentary lipaemia on the glycoproteins and the congo red-binding capacity of albumin in healthy and atherosclerotic individuals.


Role of carbon dioxide and acetate in biosynthesis by sulphate-reducing bacteria.


Sequestration of protein by the fat body of an insect.


Cold weather and ischaemic heart disease.


Haematological study of some common anaesthetics in dogs.


The use of pericardial sac as a cardiometer--a technique for recording the effects of DRUGS ON HEART IN SITU.


Vital capacity and maximum breathing capacity in Gujaratis.


A study on gonadal hormones in relation to tumors of ovaries.


Effect of Gurmar and shilajit on body weight of young rats.


Preliminary pharmacological studies on Convolvulus pluricaulis chois--an Indian indigenous herb.


Correlation between chlorides of blood and acidity of the gastric juice.


An ultrastructural study of the effects of aeration and physical activity on aging in Tetrahymena pyriformis.


Reversible delay of normal development of frog embryos by inhibition of DNAsynthesis.


Chemical and morphological studies on inorganic phosphate deposits in Rana catesbeiana skin.


Reciprocal transplantation of eggs between rabbit and ferret.


The identification of wood fragments.

The identification of wood fragments.


Identification from a bite mark in cheese.


The California Association of Criminalists.


Catalytic process for restoration of serial numbers on aluminum.


, Harding DM, Dougherty PM: Identification of seeds of Ipomea purpurea (morning glory family reported to have psychotomimetic properties) by paper chromatography.


Problems and advantages of test firing weapons into water.


The attitude of pregnant females on family planning.


Treatment of hypochromic anaemias in protein-calorie deficiency with Jectofer (iron-sorbitol).


Birthweight and birth length of newborns in Bandung.


Total synthesis of crystalline insulin.

Total synthesis of crystalline insulin.


Studies on the mechanism of inductive formation of tryptophan pyrrolase in rat liver. Enzyme induction by the ribonucleic acid from rat liver.


Stereoselective synthesis of the anomeric 5-mercapto-2'deoxyuridines and of some other alpha-and beta-deoxyribonucleosides.


Shear, wall interaction and hemolysis.

Shear, wall interaction and hemolysis.


Silastic catheter for peritoneal dialysis.


Red blood cell survival after prolonged perfusion with a blood pump.


A pseudoendocardium for implantable blood pumps.


Antithrombogenic cellulose membranes for blood dialysis.


Semipermeable aqueous microcapsules ("artificial cells"): with emphasis on experiments in an extracorporeal shunt system.


Blood toxicity induced by in vitro oxygenation effect of temperature and hemodilution.


Heparin-bearing surfaces and liquid surfaces in relation to blood coagulation.


Use of GBH-coated Tygon tubing for experimental prolonged perfusions without systemic heparinization.


A bioelectric polyurethane elastomere for intravascular replacement.


Endocardial prosthetic junction thrombosis--an experimental study of the etiological factors.


Factors influencing blood pH changes during extracorporeal dialysis in patients with chronic renal failure.


A new plastic interface which has antithrombotic characteristics and appears to mimic the vascular interface.


Sauna baths in the treatment of chronic renal failure.


Dialysate capacity augmentation at ultra-low flow rates with activated carbon slurry.


Changes in total and ultrafilterable plasma calcium and magnesium during hemodialysis.


Rebound anticoagulation occurring after regional heparinization for hemodialysis.


A true hypercoagulability state in patients on chronic hemodialysis.


Hemodialysis in cancer chemotherapy.

Hemodialysis in cancer chemotherapy.


Platelet counts and adhesiveness during hemodialysis.


Percutaneous insertion of Teflon needles for hemodialysis.


The Silastic-Teflon arterio-venous cannula.


The winged in line shunt.

The winged in line shunt.


Perfusion of the isolated canine liver in vivo and in vitro.


The development of an intrapericardial cardiac replacement. Phase II.


Dextran gel filtration of uremic thoracic duct lymph.


Experimental model for inducing acute and chronic hyperthermia.


Heat and electromagnetic energy transport through biological material at levels relevant to the intrathoracic artificial heart.


Compact prosthetic total heart.

Compact prosthetic total heart.


An intrathoracic artificial heart controlled by fluid amplifiers.


Elimination of some problems encountered in total replacement of the heart with an intrathoracic mechanical pump: venous return.


Pacemaker site and myocardial contractility.


A new concept in membrane support for artificial lungs.


A micro-miniature radio-frequency receiver for cardiac pacing.


Studies of bioelectric power sources for cardiac pacemakers.


Further observations concerning the use of lymph for extracorporeal dialysis.


Artificial skin.

Artificial skin.


A compact hydraulic proportioning system for hemodialysis.


Unattended overnight home hemodialysis.

Unattended overnight home hemodialysis.


Further development and clinical evaluation of the Klung dialyzer.


Design, equipment, and function of a fifteen bed hemodialysis unit.


An analysis of a Veterans Administration dialysis unit.


Operating parameters and performance criteria for hemodialyzers and other membrane-separation devices.


Standards and standardization.

Standards and standardization.


Modification of Wolf's relative dialysance concept.


Comparison of physical properties and permeability of six cellulose membranes.


Left ventricular bypass in experimental left heart failure.


Maintenance of the circulation in cardiac asystole by the mechanical pulsator.


A vasomotor reflex contribution to systolic pressure reduction during diastolic augmentation.


The use of synchronized counterpulsation and post-extrasystolic potentiation in the treatment of experimental cardiogenic shock.


Prolonged circulatory support by direct mechanical ventricular assistance.


Adsorption: a step toward a wearable artificial kidney.


An externally actuated subcutaneous exteriorized "in-series" prosthetic left ventricle.


Design and operation of a paracorporeal bypass pump.


Automated peritoneal dialysis: analysis of several methods of peritoneal dialysis.


Vasoconstrictors and experimental flaps.


The effect of a proteolytic enzyme combinate (bromelain) on the postoperative oedema by oral application. A clinical and experimental study.


Thalidomide and congenital cleft deformities.


The demand for removal of tattoos. A plea for regulations against tattooing of minors.


Exposure and dressings in the treatment of burns in outpatients.


The results of treatment of electrical burns. A clinical report of 27 cases.


Electric mouth burns in children. Treatment and prevention.


Arteriovenous fistulas of the face. Report of 2 cases.


Studies on velopharyngeal closure.

Studies on velopharyngeal closure.


Tibia as donor area of bone grafts in infants. Influence on the longitudinal growth.


Giant ameloblastic tumours of the lower jaw. Report of three reconstructed cases.


Treatment of basal cell carcinoma by plastic surgery.


Intravital measurements during instrumental correction of idiopathic scoliosis.


Post-traumatic osteopenia. A quantitative study of the bone mineral mass in the femur following fracture of the tibia in man using americium-241 as a photon source.


"The signs of the slightly long leg".

"The signs of the slightly long leg".


Measuring ureteral radiation doses.

Measuring ureteral radiation doses.


Prelude to the great march of orientating health work towards the rural areas: some questions concerning the work of the rural mobile medical teams.


Effects of certain drugs on permeability of blood-aqueous barrier to urea.


The development of muscular dystrophy in children with residual from poliomyelitis.


Malignant lymphomas with special manifestations.


Dislocation of the sacroiliac joint.

Dislocation of the sacroiliac joint.


Metabolic observations following total pancreatectomy.


The use of vacuum bottle in therapeutic abortion; a collective survey.


Thrombocytopenia following administration of penicillin. Report of a case.


Clinical manifestations of rheumatic mitral disease in childhood.


Tumor cells in the thoracic duct lymph in carcinoma of esophagus and cardia of stomach.


Mesonephric adenocarcinoma of the vagina in an infant. Report of a case.


Hereditary brachyhyperphalangia in a Chinese family.


Amino acid requirements of Hypoderma bovis (L.), determined with glucose-U-14C.


Histochemical localization of beta-glucuronidase in schistosomes.


Stress and parasitism. IV. Cold stress and Entamoeba.


Studies on the metabolism of larval tapeworms (Cyclophyllidea: Taenia crassiceps). II. Respiration, glycogen utilization, and lactic acid production during culture in a chemically defined medium.


Ultrastructure of Trypanosoma cruzi in the rectum of Rhodnius prolixus.


X-ray diffraction analysis of ice crystals in coniferous pollen.


Determination of some water-soluble vitamin levels in Planorbidae.


Comparison of liquid propane and liquid nitrogen in tissue preservation.


Effect of various synergists on toxicity and in vivo metabolism of DDT in Triatoma infestans nymphs.


Drug responsiveness in experimental cutaneous leishmaniosis.


Effect of dimethyl sulfoxide on cooling rates of unrestrained rats.


Ultrastructural studies of enzyme activity in the cestode cuticle.


Influence of male and female Ancylostoma caninum on each other's distribution in the intestine of the dog.


Osmotic and ionic regulation in Fasciola gigantica (Trematoda: Digenea).


Formation of the L-proline pool of the cestode, Hymenolepis diminuta.


Chemical studies on hamycin. I. Purification, counter-current distribution and chemical degradation.


The effects of some antibiotics on the ciliary movement and a discussion on their clinical implications.


Testing procedures for evaluation of antiamoebic drugs in vitro and in experimental animals.


Thin layer chromatography of pigments from Penicillium herquei.


Streptocycline, an effective antibiotic against bacterial plant pathogens.


A comparison of the hapten-binding affinities of 7S and 19S antibodies.


Delayed capillary, mast cell and connective tissue response to norepinephrine in the skin of rats.


Hemadsorption by murine tumors.

Hemadsorption by murine tumors.


A study of delayed hypersensitivity in guinea pigs injected with antigen-antibody complexes.


The effect of a methylhydrazine derivative on experimental immune thyroiditis in guinea pigs.


Calorimetric determination of the half-life of antimony-124.


Sr90-Y90 extracorporeal irradiator.

Sr90-Y90 extracorporeal irradiator.


The determination of mercury in potato flour.


The synthesis of O-18-labelled hydrogen peroxide in H-2O-16.


The development of cellular stalks in bacteria. Extensive stalk elongation in Caulobacter and Asticcacaulis can be obtained in a defined medium by limiting the concentration of phosphate. Caulobacter cells which were initiating stalk formation were labeled with tritiated glucose. After removal of exogenous tritiated material, the cells were subjected to phosphate limitation while stalk elongation occurred. The location of tritiated material in the elongated stalks as detected by radioautographic techniques allowed identification of the site of stalk development. The labeling pattern obtained was consistent with the hypothesis that the materials of the stalk are synthesized at the juncture of the stalk with the cell. Complementary labeling experiments with Caulobacter and Asticcacaulis confirmed this result. In spheroplasts of C. crescentus prepared by treatment with lysozyme, the stalks lost their normal rigid outline after several minutes of exposure to the enzyme, indicating that the rigid layer of the cell wall attacked by lysozyme is present in the stalk. In spheroplasts of growing cells induced with penicillin, the stalks did not appear to be affected, indicating that the stalk wall is a relatively inert, nongrowing structure. The morphogenetic implications of these findings are discussed.


Uridine-5-H3 radioautography of the human sex chromatin body. To obtain an estimate of the rate of RNA synthesis by the heterochromatic sex chromatin body, human female fibroblasts were labeled with uridine-5-H(3) and radioautographed. The number of grains over the sex chromatin body was compared with the number of grains over a comparable area of euchromatin. The ratio was 0.37. When corrected for the higher content of DNA per unit area in heterochromatin, the maximum rate of RNA synthesis by the DNA of the sex chromatin body was approximately 18% of the rate of RNA synthesis by a comparable amount of euchromatin DNA. The rate of RNA synthesis by the sex chromatin body did not increase significantly with partial despiralization of this chromatin at prophase.


Fractionation of spinach chloroplasts by flow sedimentation--electrophoresis. A separation of spinach chloroplasts in vitro into fractions according to size (volume) and activity (light-dependent shrinkage and NADP reduction) has been achieved by stable-flow free boundary sedimentation-electrophoresis. The salient features of this chloroplast study are: (a) separation is achieved within 30 min; (b) only small density gradients are required, thus minimizing osmotic effects; (c) the fractions are collected continuously, with size fractionation being evidenced; and (d) particles are separated into fractions of higher and lower activities as compared with the control population.


The nucleoids of rat liver cell microbodies. Fine structure and enzymes. The nucleoids of microbodies of rat liver cells were isolated in a highly homogeneous and pure state, by treating the microbody-rich fraction, prepared from 10% polyvinylpyrrolidone-0.25 M sucrose homogenate, with Triton X-100. Three treatments with 0.1% detergent were enough to render the nucleoids free from contamination with mitochondria, microsomes, lysosomes, and intact microbodies. Electron microscopically, the nucleoids were found to consist of parallel bundles of highly dense hollow tubules, the outer and inner diameters of which are approximately 150 and 50 A, respectively. Ten tubules are arranged around a longitudinal space 190 x 200 A in width. The nucleoids thus show a honeycomb appearance in the cross-plane and a parallel-packed structure in the longitudinal plane. Biochemically, the nucleoids were found to bear only urate oxidase among probably microbody-enzymes, and they might be the only cytoplasmic particles of rat liver cells in which the enzyme locates. Urate oxidase activity, on a unit protein basis, of the nucleoid preparation is approximately 380 times as high as that of the whole homogenate, and is almost comparable with that of a commercial type I enzyme preparation. No enzymes of mitochondrial, microsomal, and lysosomal origins were detected in the nucleoids. The fine structure of the nucleoids is described in detail, and a probable schematic diagram is presented.


Structural organization of the retina in the tree shrew (Tupaia glis). This investigation was undertaken to establish the gross and ultrastructural organization of the photoreceptors and retina in the Malayan tree shrew (Tupaia glis). Photographs of the fundus revealed no specialization or differentiation of a central foveal region. Histologic sections revealed a single row of relatively short and thick cones distributed uniformly throughout the retina. Electron micrographs of the retina indicated that the receptor outer segments are closely invested by pigment-filled epithelial processes and an amorphous interstitial material. The internal fine structure of the receptor outer segments revealed the characteristic stacks or arrays of bimembranous discs. The ellipsoid portions of the cone inner segments include tightly packed and extraordinarily large mitochondria. These mitochondria consist of unique patterns of concentric cristae arranged in highly ordered whorls of lamellar configurations. The cone synaptic pedicles contain a unique system of tubules not previously described in synaptic endings. Histologic sections indicated that only cone populations are located in the central region of the retina, whereas histologic, histochemical, and ultrastructural comparisons suggested that photoreceptors with some "rodtype" features are located more peripherally. The relatively small proportion of these rodtype receptors among the great preponderance of cone populations is in general accord with the tree shrew's diurnal habits as well as its great reliance on photopic vision and its visually guided behavior.


The myofilament arrangement in the femoral muscle of the cockroach, Leucophaea maderae fabricius. The structure of the femoral muscle of the cockroach, Leucophaea maderae, was investigated by light and electron microscopy. The several hundred fibers of either the extensor or flexor muscle are 20 to 40 micro in diameter in transverse sections and are subdivided into closely packed myofibrils. In glutaraldehyde-fixed and epoxy resin-embedded material of stretched fibers, the A band is about 4.5 micro long, the thin filaments are about 2.3 micro in length, the H zone and I band vary with the amount of stretch, and the M band is absent. The transverse sections of the filaments reveal in the area of a single overlap of thick and thin filaments an array of 10 to 12 thin filaments encircling each thick filament; whereas, in the area of double overlap in which the thin filaments interdigitate from opposite ends of the A band, the thin filaments show a twofold increase in number. The thick filament is approximately 205 to 185 A in diameter along most of its length, but at about 0.2 micro from the end it tapers to a point. Furthermore, some well oriented, very thin transverse sections show these filaments to have electron-transparent cores. The diameter of the thin filament is about 70 A. Transverse sections exhibit the sarcolemma invaginating clearly at regular intervals into the lateral regions of the A band. Three distinct types of mitochondria are associated with the muscle: an oval, an elongate, and a type with three processes. It is evident, in this muscle, that the sliding filament hypothesis is valid, and that perhaps the function of the extra thin filaments is to increase the tensile strength of the fiber and to create additional reactive sites between the thick and thin filaments. These sites are probably required for the functioning of the long sarcomeres.


New features of amyloid found after digestion with trypsin.


Osmiophilic lamellated bodies and associated material in lung alveolar spaces.


Localization of chlorophyll in spinach chloroplast lamellae by fluorescence microscopy.


Global health factors of importance to Canadian mobile forces with a potential world-wide commitment.


Identification of bacteria by bacteriophage.


The effect on intellectual performance of minimal dosage of a depressant (benadryl--50 mg.) and of a stimulant (dextro-amphetamine--5 mg.).


Presence in lipoproteins from human serum of a crystalline blue fluorescent substance of unknown structure isolated from bovine liver.


Renal clearance of cytochrome C in rat.

Renal clearance of cytochrome C in rat.


Experimental production of malformations due to acetyl salicylate and phenyl salicylate in rats.


A comparative study of dipterex and tartar emetic in the treatment of urinary schistosomiasis.


Subarachnoid hemorrhage with vertebro-basilar aneurysm. Report of 8 cases with medical management; no deaths.


Studies on cross-resistance in schistosome and Ascaris sum infections of mice.


Inhibitory action of desmethylimipramine on the restoration of the pressor effect of tyramine and on the uptake of noradrenaline in the reserpinized dog.


A new reaction for glycine biosynthesis.


On the elucidation of the pH dependence of chymotrypsin catalyzed reactions at alkaline pH.


Increase in sodium concentration of the isolated frog retina after light stimulation.


Activation of chymotrypsin catalyted hydrolyses by 9-aminoacridine.


Incorporation of arginine by a soluble system from sheep thyroid.


On the effect of adenosine 3',5' cyclophosphate on the kinase of UDPG:alpha-1,4-glucan alpha-4-glucosyl transferase.


Photolysis of L-tyrosine and photomodification of peptides.


Selective precipitation of monomeric ribosomes by bentonite.


Enzymatic ATP formation from ADP and phosphoramidate.


Instability of cerebral proteins.

Instability of cerebral proteins.


Biosynthesis of thyroglobulin: absence of 14-C-glucosamine incorporation on thyroid polysomes.


The enzymatic synthesis of a glucomannan.


Repetitions in the polypeptide sequence of cytochromes.


The prosthetic groups of animal amine oxidases.


Detection of anti-insulin antibodies with a new electrical technique: lipid membrane conductometry.


Exchange of F-actin-bound nucleotide in the presence and absence of myosin.


Nature of the acquired haemagglutinating property of classical V. cholerae.


Smallpox--mild and severe.

Smallpox--mild and severe.


Electron microscopic study of measles infected FL cells.


Staphylococcal infection in hospitals. The aspect of staphylococcal infection in our hospital.


A selective blockade of the cardiac inotropic effect of adrenaline by sodium monofluoroacetate.


Postoperative pulmonary complications.

Postoperative pulmonary complications.


Statistical studies on the brain injuries, their occurrence, treatment, and prognosis.


A clinico-genetical and electroencephalographical study of epilepsy.


Amine production from amino acid by Penicillium graucum.


About a possible mechanism involved in the shedding of sea urchins.


Effect of some monoamine oxidase inhibitors on deamination of biogenic monoamines by rat liver mitochondrial monoamine oxidase.


Succinic dehydrogenase and isocitric dehydrogenase activities in vitamin E-sufficient and -deficient fetal rats.


Methods for the separation, purification and measurement of nine components of hemolytic complement in guinea-pig serum.


Inverted perception of time sequence in mental disorders.


Keratoconjunctivitie sicca in a dog treated by transposition of the parotid salivary duct.


The chemorelease of norepinephrine from mouse hearts. Structure-activity relationships. I. Sympathomimetic and related amines.


The depletion of norepinephrine-3H from heart by alpha-methyl-m-tyrosine. A novel and convenient method for assaying the inhibition of aromatic amino acid decarboxylase in vivo.


Metabolism of metaxalone.

Metabolism of metaxalone.


Design and synthesis of thiolesters for the histochemical demonstration of esterase and lipase via the formation of osmiophilic diazo thioethers.


Electronic structures of some N-alkyl-substituted amides of interest as cholinesterase inhibitors.


Application of partition coefficients, electric moments, electronic structures, and free-energy relationships to the interpretation of cholinesterase inhibition.


Octahydrophenanthrene analogs of tetrabenazine.


The syntheses and hypotensive activities of some substituted 1,4-diazabicyclo[4.4.0]decanes.


Synthesis and antiinflammatory activity of a series 1-aryl-2-pyrrolidinone derivatives.


Synthesis of trans-2-cyclohexyloxycyclopropylamine and derivatives.


Hypocholesterolemic agents. VI. A- and B-ring-modified azacholesterols.


The synthesis of potential anabolic agents. Steroidal oxadiazoles.


The relationship between structure and activity in a novel series of serum cholesterol-lowering agents.


Totally synthetic steroid hormones. VII. Some (+ or-)-8-alpha-estrane and (+ or -)-13-beta-alkyl-8-alpha-gonane derivatives.


Synthesis and pharmacological activity of alkylated tryptamines.


Synthesis and biological activity of some 5-, 6-, and 7-aminomethyl-2,3-dimethylindoles.


Hexahydropyrimidines. VII. A study of 2-substituted 1,3-bis(2-hydroxy-3-methoxybenzyl)hexahydropyrimidines and 2-substituted 1,3-bis(3,4-dimethoxybenzyl)hexahydropyrimidines as antitumor agents.


1-Deaza-6-methylthiopurine ribonucleoside.


Potential carcinolytic agents. 3. Fluoronitrogen mustard analogs of cyclophosphamide.


Phosphorus mustards. II. The synthesis and biological evaluation of bis(2-chloroethyl)methylphosphine hydrochloride.


Attempted synthesis of 2,4-dihydroxy-43-borazaropyridine. Preparation of aminoalkylboronic acids.


Nucleosides. 3. Studies on 5-methylamino-2'-deoxyuridine as a specific antiherpes agent.


Anticancer and potential antiviral activity of complex inorganic compounds.


Purine sulfonamides.

Purine sulfonamides.


Reactions of mercaptoamines. 3. Synthesis of N-monosubstituted 2-mercaptoethylamines.


Nitrofuryl heterocycles. IV. 4-amino-2-(5-nitro-2-furyl)quinazoline derivatives.


Nitrofuryl heterocycles.3. 3-Alkyl-5-(5-nitro-2-furyl)-1,2,4-triazoles and intermediates.


Radioprotective activity of triammonium 2-dithiocarbamoyl-3-dithiocarbonylthiopropanoate.


Organic disulfides and related substances. XVII. Analogs of o-(2-aminoethyldithio)benzoic acid as antiradiation drugs.


L-(+)-2-beta-Tropanyl diphenylborinate.

L-(+)-2-beta-Tropanyl diphenylborinate.


Carboranes. I. Nitrogen mustards.

Carboranes. I. Nitrogen mustards.


Tertiary phosphines and phosphine oxides containing a 2-haloethyl group.


Glycerol 1,3- and 1,2,4-butanetriol 1,4-bismethanesulfonates.


v-Triazolo[4,5-d]pyrimidines. 3. N-(3-alkyl-5-amino-3H-v-triazolo[4,5-d]pyrimidin-7-yl)-amino acids.


6-azauracil derivatives of fluoropyruvic acid.


The synthesis and antitumor activity of several thiosemicarbazones related to kethoxal bis(thiosemicarbazone).


Synthesis of potential antineoplastic agents. 13. 1-p-[Bis(2-chloroethyl)amino] benzyl -pyridinium p-toulenesulfonate and related compounds.


2,4-Bis(arylamino)pyrimidines as antimicrobial agents.


Nitrofuryl heterocycles. II. 2-Alkyl-6-(5-nitro-2-furyl)-3(2H)-pyridazinones and 4,5-dihydro derivatives.


Halonitroanilides and their bacteriostatic activity.


Derivatives of 5-carboxymethylthiazolidine-2,4-dione, a new group of antiviral compounds.


3-Aryl-5-halomethylisoxazoles. A new class of anthelmintics.


Syntheses and properties of mono-, di-, and tritestosteroxysilanes.


Some alkylideneaminooxyalkanoic acids and derivatives.


Compounds affecting the central nervous system. II. Substituted 1,2,3,4-tetrahydropyrido[4,3-b]indoles.


Indole hydrazides as potential monoamine oxidase inhibitors.


DL-2-Hydrazino-3-(4-hydroxyphenyl)propionic acid.


2-Methyl-3-phenoxycyclopropylamine.


Agents affecting lipid metabolism. XXI. Miscellaneous compounds related to trans-1,4- bis(2-chlorobenzylaminomethyl)cyclohexane.


t-Butyl ester of 7-aminocephalosporanic acid.


Some ureas and urethans derived from p-aminophenol.


The six trimethoxyphenylisopropylamines (trimethoxyamphetamines).


Substrates for cytochemical demonstration of enzyme activity. II. Some dihalo-3-indolyl phosphates and sulfates.


N-Substituted DL-aspartic acids and beta-methyl esters.


N-[(4-Tolylsulfonyl)carbamoyl]amino acids.


Substituted 2-phenoxypropionic and -butyric acids and derivatives.


Mannitol augmentation of I-131 uptake in the treatment of thyroid carcinoma.


Hyperlipidemia and hypercholesterolemia after diversion of pancreatic venous drainage into vena cava.


Urinary hydroxyproline and the bone in primary and secondary hyperparathyroidism.


Stop-flow analysis in man.

Stop-flow analysis in man.


Glucose-6-phosphate dehydrogenase activity in adipose tissue from two types of obese mice during starvation.


The effects of starvation and refeeding on hexosemonophosphate shunt enzyme activity and DNA, RNA, and nitrogen content of rat adipose tissue.


Inhibition of endogenous TSH in the rat by graded doses of TSH-antiplasma.


The effect of growth hormone on the metabolism of lipids and on urea formation by the perfused rat liver.


The conversion of protoporphyrin-C14 to heme compounds and bilirubin in dogs.


Early labeling of bilirubin from glycine and delta-aminolevulinic acid in bile fistula dogs, with special reference to stimulated versus suppressed erythropoiesis.


Plasma insulin response to intravenously administered xylitol in dogs.


Needle biopsy of the parietal pleura in children.


The metabolism of 4-14C-delta-1-testololactone.


Value of differential carotid angiography in selected neurosurgical problems.


Neonatal ascites and urinary-tract obstruction.


Histoplasmosis of the tongue.

Histoplasmosis of the tongue.


Formation of 4-C14-corticosteroids in slices of bovine adrenal cortex using 4-C14-progesterone as precursor.


Fundamental studies on the prevention of industrial metal poisoning with the author's concept to the occupational health.


Interspike interval fluctuations in the crayfish stretch receptor. Trains of nerve impulses from the crayfish stretch receptor under steady conditions are found to be extremely regular with a standard deviation of S = 0.7 x 10(-2)tau when tau, the mean interval, is in the 15 to 80 msec range. Such a small fluctuation increases the problems of film recording, accurate measurement of intervals, and especially, drifts. Experimental and mathematical techniques are described to obviate these problems. Evidence is found for a serial correlation coefficient of about -0.2 in the range, tau = 35 msec to tau = 70 msec. Shot noise and Johnson noise in a long axon are evaluated in detail and are shown to be comparable in size. It is also shown that neither shot noise nor Johnson noise is large enough to explain simply the observed interval fluctuations. Other types of membrane noise are discussed.


Is gum karaya (Sterculia urens Roxb. Family: Sterculiaceae) allergenic?


Enzyme studies on carbohydrate metabolism in some clinical conditions. II. A modified method for the determination of pyruvate kinase in red blood cell.


Synthesis 4-n-propyl-2-methylcyclopentan-1-one-4-carboxylic acid.


Triterpenes of Artocarpus lakoocha Roxb.


Use of corticosteroids in persistent "lepra reaction".


Fluid therapy of cholera in children.

Fluid therapy of cholera in children.


Haemagglutinating activity of classical V. Cholerae.


Mepacrine and chloroquine in vitiligo.

Mepacrine and chloroquine in vitiligo.


Combined therapy of amoebic dysentery.

Combined therapy of amoebic dysentery.


Clinical trial of furoxone in amoebic dysentery.


Chemotherapy and control of cholera.

Chemotherapy and control of cholera.


Erythrocytic adenosine triphosphate (ATP) level and its stability in Hb. E-thalassaemia.


Comparative study of haemagglutination-inhibiting-antibody and neutralising antibody in sera of cases of smallpox.


Preliminary observations of the effect of "crowding" on the development and hatching of hookworm eggs.


Leptospiral antibodies in random human population in Calcutta.


Some ultrastructural aspects of Vibrio cholerae.


House-frequenting mosquitoes of West Bengal and Calcutta: detection of filarial parasites in Anopheles and culex spp.


Clinico-genetic study on obsessive compulsive neurosis.


Synthesis and preliminary pharmacological evaluation of alkylpiperazine esters.


Histochemical studies on Gomori-positive substances. 3. Examination of the earthworm's neurosecretory system. (Lumbricus herculeus, Eisenia foetida).


Comparative histological investigations on marine lamellibranch adductors in different functional conditions.


Electron microscopic observations on the special cells of the optic tentacle of Helicella obvia (Pulmonata).


Comparative biochemistry of hemoglobins. V. On the N-terminal structure of the protein moiety from rat adult hemoglobin.


A pancreatic protein anabolic extract. Proposal of a protein anabolic extract from pancreas. I. Preliminary report.


Study on audiometry for preschool children by use of telephone set.


Comparative biochemistry of hemoglobins. IV. A study on the alpha- and beta-polypeptide chains from components A-I and A-II of chicken hemoglobin by the fingerprinting method.


A versatile split-beam ultracentrifuge recording scanner for use with multicell rotor and absorption optics.


The true oxidized glutathione content of red blood cells obtained by new enzymic and paper chromatographic methods.


Improved chromatographic fractionation and characterization of human plasma proteins.


The chemical estimation of ketone bodies.


A micro fluorometric method for determining spermidine.


A column method for deoxygenating human hemoglobin.


A versatile spectrophotometric scanner for large TLC plates.


Estimation of sulfur in biological materials by atomic absorption spectrometry.


Spectrophotometric assay for hexosamines.


Enzymic method for determination of hydroxyproline.


Gas chromatography of sugar phosphate.

Gas chromatography of sugar phosphate.


Gas chromatography of phenolic acids.

Gas chromatography of phenolic acids.


A simple density gradient generator.

A simple density gradient generator.


Automated analysis for thiourea and its derivatives in biological fluids.


An improved column for gas-liquid chromatography of substituted cholanic acids.


Gas chromatography of urinary homogentisic acid.


Determination of traces of calcium in commercial adenosine triphosphate (ATP).


Stimulation of staphylococcal nitrate reductase production by chloramphenicol.


Correlation of membrane bound succinate dehydrogenase with the occurrence of mitochondrial profiles in Saccharomyces cerevisiae.


Automatic amino-acid-sequence determination in peptides.


Organic structural specificity of coenzyme Q for biological activity.


Reduction of N2O by biological N2-fixing systems.


Kinetics of light-induced absorbance changes in Rhodospirillum rubrum extracts.


Replication of bacteriophage RNA: purification of the replicative intermediate by agarose column chromatography-1.


Thyroglobulin maturation in rat and nomenclature of thyroglobulin-like proteins.


The formation of circular DNA after lysogenic induction.


On the contribution of the tricarboxylic acid cycle to the synthesis of glutamate, glutamine and aspartate in brain.


Reversible activation and inactivation of mitochondrial malate dehydrogenase with para-hydroxymercuribenzoate.


The energy linked synthesis of pregnenolone in beef adrenal cortex mitochondria.


Evidence that the dark repair system of coliphage T 4 is controlled by the viral genome.


Mitomycin C induced increases in the activities of the deoxyribonucleases of HeLa cells.


Nuclear magnetic resonance study of sulfated mucopolysaccharides.


The steroid activity and multiplicity of crystalline horse liver alcohol dehydrogenase.


An N-acetylated peptide chain in tropomyosin.


The non-acetylated N-terminal sequence of the green tomato atypical mosaic virus coat protein (G-TAMV).


Reversible conversion of horseradish paraperoxidase (low spin) into normal peroxidase (high spin) by sulfhydryl reagents.


Photometric determination of cell permeability at constant volume.


On the nature of tyrosine phosphorescence from proteins.


Electro-optical properties of nucleic acids and nucleoproteins. I. Study of the gel-forming deoxyribonucleohistone.


Physical studies of phospholipids. II. Monolayer studies of some synthetic 2,3-diacyl-DL-phosphatidylethanolamines and phosphatidylcholines containing trans double bonds.


A re-examination of Stein's dimer theory of sugar transport in human erythrocytes.


On the binding of condensed phosphates by proteins.


Fluorescence spectra of human serum albumin in the pH region of the N-F transition.


Some properties of spinach chloroplast fractions obtained by digitonin solubilization.


Purine metabolism by unicellular algae. 3. The photochemical degradation of uric acid by chlorophyll.


Fluorescence studies on a red alga, Porphyridium cruentum.


Fluorescene of chlorophyll in photosynthetic systems. II. Induction of fluorescence in isolated spinach chloroplasts.


Analyses of light-induced bacteriochlorophyll absorbance change and fluorescence emission in purple bacteria.


Energy- and electron-transfer systems in algal photosynthesis. I. Actions of two photochemical systems in oxidation-reduction reactions of cytochrome in Porphyra.


The inhibitory effect of light on growth of Prototheca zopfii Kruger.


Aerobic oxidations catalyzed by catechol.


Amino acid transport by the small intestine of the rat. The existence and specificity of the transport mechanism of imino acids and its relation to the transport of glycine.


Stability constants of uranyl chelates with nuclear-substituted salicylic acids.


Studies of poly-beta-benzyl-l-aspartate helix. II. The circular dichroism and optical rotatory dispersion of copolymers of beta-p-methyl, chloro, or cynabenzyl-l-aspartate with beta-benzyl-l-aspartate.


Studies of poly-beta-benzyl-l-aspartate helix. I. The synthesis and rotatory dispersion of copolymers of beta-p-methyl, chloro, cyano, or nitrobenzyl-l-aspartate with beta-benzyl-l-aspartate.


Mortality of New England dentists; 1921-1960.


Kininase activity in asthmatic serum.

Kininase activity in asthmatic serum.


Immunologic cross-reaction between luteinizing hormone and antisera to human chorionic gonadotropin.


Inhibition of thrombohemorrhagic phenomena by 'oversensitization'.


Presence of antibodies against egg-white antigens in human lymphoid tissues.


Gas chromatographic analysis of histamine metabolites in urine. Excretion of labelled material in dogs.


Gas-liquid chromatography of submicrogram amounts of drugs. I. Preparation, scope and limitation of columns.


Enhancement and modification of isotope fractionation during the partition chromatography of 3-H and 14-C labeled steroids.


Detection and thin-layer chromatography of sulfur compounds. I. Sulfoxides, sulfones and sulfides.


Polyamide layer chromatography of DNP-amino acids.


Quality testing of chromatographic data with the aid of a statistical criterion.


Biochemistry of sphingolipids. IV. Some new paper chromatographic systems for the characterization of sphingolipids.


A quantitative automated technique for the determination of diazotizable imidazole compounds in biological material.


Chromatography of amino acids on plaster of Paris.


Separation with uni-dimensional TLC of all neutral lipid classes.


RNA metabolism in the HeLa cell nucleus.


Paper chromatography of 5-substituted tryptophans.


Separation of p-nitrophenol and p-nitro-m-cresol from urine pigments by thin layer chromatography.


The effect of urea on histones in polyacrylamide gel electrophoresis.


Electron microscopic studies of detergent-treated HeLa cell nuclei.


Polymers tripeptides as collagen models. II. Conformational changes of poly(L-prolyl-glycyl-L-prolyl) in solution.


Persistence of native ribosomal subunits during reticulocyte maturation.


The structure of poly-5-methylcytidylic acid and its twin-stranded complex with poly-inosinic acid.


The properties and interactions of the isolated alpha- and beta-chains of human haemoglobin. IV. Immunological studies involving antibodies against the isolated chains.


The properties and interactions of the isolated alpha- and beta-chains of human haemoglobin. V. The reaction of alpha- and beta-chains.


The utility of pi-electron acceptors for the detection of 3,4-methylenedioxy-phenyl derivatives.


A method to determine the number of DNA replicating units in cultured mammalian cells.


The interaction of acridine dyes with DNA: an x-ray diffraction and optical investigation.


Retinal ganglion cell response to sinusoidal light stimulation.


Effect of colicine E2 on the biosynthesis of bacteriophage R17.


Conductance changes during inhibitory postsynaptic potentials in normal and strychninized cortical neurons.


Neocortical interconnections in the cat.


Optic projections to nonvisual cortex of the cat.


Monosynaptic excitation of motoneurons of individual forelimb muscles.


Pacemaker site of fibrillation potentials in denervated mammmalian muscle.


Auditory evoked cortical potentials after lesions of brachium of inferior colliculus.


Inhibition of central vestibular neurons from the contralateral labyrinth and its mediating pathway.


Effect of stimulation of interstitial nucleus of Cajal on vestibular unit activity in the cat.


Visual search experiment: noise persistence, acuity, response time.


Some factors affecting the appearance of the Mach bands.


Lightness change of grays induced by change in reflectance of gray background.


Depth-discrimination thresholds for stationary and oscillating targets at various levels of retinal illuminance.


Takayasu's disease.

Takayasu's disease.


A descriptive study of ectopic pregnancies in the Maternity and Children's Hospital from 1960 to 1964.


Debridement--the big difference.

Debridement--the big difference.


May a dentist legally perform mandibulectomy?


Second PMA--Dr. Jose Rizal Memorial Lecture. The spirit of scientific medical research.


Code of medical ethics of the medical profession in the Philippines.


Prolongation of barbiturate sleeping time in mice by stimulation of the reticuloendothelial system (RES).


Influence of an extract of Mycobacterium phlei on water intake and its neutralization by antibody.


Effect of a reticuloendothelial-depressing substance on survival from shock.


Radioresistance of the engulfing and degradative capacities of peritoneal phagocytes to kiloroentgen x-ray doses.


Digestive vacuole formation in alveolar macrophages after phagocytosis of Mycobacterium smegmatis in vivo.


Medical careers in public health. A commentary.


The University of North Carolina study of public health physicians.


Medical students' attitudes toward public health.


A comparison of career patterns of public health physicians and other medical specialists.


Toward a typology of public health careers.


The novice physician in the local public health service. A study of continuities in the patterns of recruitment.


DDT residues in Adelie penguins and a crabeater seal from Antarctica.


Guessing as a form of intelligent behaviour.


The transiency of physicians in public health. Study of a cost factor in institutional work.


Cellular control systems and radiosensitivity.


Reaction kinetic studies of the antigen-antibody reaction.


Effect of desaspidin on photosynthetic phosphorylation and related processes.


Blood samples from the pituitary stalk of the rat: method of collection and factors determining volume.


Accelerating and decelerating actions of adrenalin on epidermal mitotic activity.


Relative growth of trophoblast and tumour cells co-implanted into isogenic mouse testes and the inhibitory action of 'methotrexate'.


Acetylcholine-like activity of acetyl-l-carnityl CoA in the brains of narcotized rats.


Trans to cis isomerization of urocanic acid.


Cortisone-induced lipaemia and hepatic steatosis in the male rat.


In vivo conversion of gamma-hydroxybutyrate into gamma-aminobutyrate.


Effect of age and nephrectomy on epsilon-lysine acylase of rat kidney.


Method of recording simultaneously the positions of labelled and unlabelled compounds on autoradiographs.


Extracellular recording of converging input on cortical neurones using a flexible microelectrode.


Inhibition of beta-D-glucosiduronic acid conjugation by eugenol.


A new class of hypotensive agents.

A new class of hypotensive agents.


Strain and sex dependency of pre-albumin in mice.


Antibody nature of the inhibitor to antihaemophilic globulin (Factor 8).


Antigenicity of soluble protein in the presence of high levels of antibody: a possible mode of action of the antigen adjuvants.


Ultrastructural aspects of duodenal crypts in X-irradiated mice after chemical protection.


Oxytocin and the life-span of male rats.


Mast cells in the central nervous system.


A structural specialization at nodes of Ranvier in the central nervous system.


Pertinacity of host-seeking behaviour of Aedes aegypti.


'Catalysomes' or enzyme caps on lipid droplets: an intracellular organelle.


Chromosome breakage with two isomers of 1-threitol 1,4-bis methanesulphonate in plants.


Change in transfer function of joint receptor output.


Intermodal transfer of adaptation to displacement.


[Rapid test for the diagnosis of syphilis with a treponema antigen].


The influence of free oxygen at high concentrations on the rate of alcoholic fermentation in a yeast showing a negative Pasteur effect in succinic acid-succinate buffer.


Ribonucleic acid in the silk-gland of silkworm (Attacus ricini).


Local and stray light components of the human electroretinogram due to stimulation by light subtending a 20 degree visual field.


Morphological investigations on the metacercaria of Pagumogonimus skrjabini, with notes on the histochemical studies of its cyst wall.


The physiological age of Culex fatigans and its relationship to the transmission of Wuchereria bancrofti.


Current mortality report.

Current mortality report.


Worldwide rise in motor vehicle accident fatalities.


Widows and widowhood.

Widows and widowhood.


The cycle of viral hepatitis.

The cycle of viral hepatitis.


Decline in mortality from thyroid disorders.


IUPAC-IUB combined commission on biochemical nomenclature. Abbreviations and symbols for chemical names of special interest in biological chemistry. Revised tentative rules (1965).


Metabolism of unsaturated fatty acids in protozoa.


Metabolic transformations of cortisol-4-[14C] in human skin.


Immunochemical studies on the tobacco mosaic virus protein. 3. The degradation of an immunologically active tryptic peptide of tobacco mosaic virus protein and the reactivity of the degradation products with antibodies to the whole protein.


The structure of the Aerobacter aerogenes A3(S1) polysaccharide. I. A reexamination using improved procedures for methylation analysis.


Immunochemical studies on blood groups. XXXV. The activity of fucose-containing oligosaccharides isolated from blood group A, B, and H substances by alkaline degradation.


Nucleotides in the encysted embryos of Daphnia magna.


Synthetic polypeptides containing side-chain amide groups. Water-soluble polymers.


Hydrophobic interactions in proteins. The alkane binding site of beta-lactoglobulins A and B.


Equilibria in the fibrinogen-fibrin conversion. VI. Ionization changes in the reversible polymerization of fibrin monomer.


Equilibria in the fibrinogen-fibrin conversion. VII. On the mechanism of the reversible polymerization of fibrin monomer.


The number of polypeptide chains in rabbit muscle aldolase.


Purification and properties of dipeptidyl transferase (Cathepsin C).


The ribonucleic acid content of turnip yellow mosaic virus.


Protein synthesis by cell-free extracts from castor bean seedlings. I. Preparation and characteristics of the amino acid incorporating system.


Formation of isocaproaldehyde in the enzymatic cleavage of cholesterol side chain by adrenal extract.


Enthalpy changes accompanying the transfer of a methyl group from S-adenosylmethionine and other sulfonium compounds to homocysteine.


Respiration-dependent proton movements in rat liver mitochondria.


Effect of androgen on the incorporation of orotic acid-6-14C into the ribonucleic acids and free nucleotides of mouse kidney.


The synthesis, structure, and optical properties of some copolypeptides containing nonpolar amino acid residues.


The conformational stability of alpha-helical nonpolar polypeptides in solution.


Protonation of polypeptides in helix-breaking solvents. Electrical conductance.


Labeling of amine-acceptor cross-linking sites of fibrin by transpeptidation.


Sedimentation and actinomycin D binding studies of partially denatured crab dAT.


Iodocarboxypeptidase.

Iodocarboxypeptidase.


Isolation and some properties of human metallothionein.


Studies on bilirubin sulphate.

Studies on bilirubin sulphate.


Investigations on the structure of the capsular polysaccharide from Cryptococcus neoformans type B.


Transfer of N-acetylneuraminic acid to incomplete glycoproteins associated with microsomes.


Complementation in vitro between non-allelic Drosophila mutants deficient in xanthine dehydrogenase. 3. Observations on heat stabilities.


The cleavage in vitro of the cross-links in gelatin by beta-aminopropionitrile.


The combination of haptoglobin 2-2 with the oxy and deoxy forms of human haemoglobin before and after digestion by carboxypeptidase A, and with isolated alpha-chains.


Interrelationships of sulfur amino acids in the pool and cellular protein of Neurospora crassa.


Relationships between the copper atoms of caeruloplasmin. I. Studies on the exchange of 64 Cu with caeruloplasmin.


Microelectrophoresis of proteins on nitrocellulose membranes.


Conversion of cortisol to tetrahydrocortisol by cultured chick-embryo femora.


Recycling chromatography with zone sharpening.


Further evidence on the structure of cordycepin.


Role of the carboxyl group in intestinal amino acid transport.


Inhibition of yeast growth by fluoride and its reversal by phosphoric esters: an effect of pH.


Amino acid composition of telomycin-producing streptomyces.


Isolation of L-alpha-aminoadipic acid from hog liver.


Hemoglobin Jenkins or hemoglobin-N-Baltimore or alpha-2-beta-2 95Glu.


Occurrence of a mammalian alpha-N-acetyl-D-galactosaminidase.


Influence of abode and season on the vitamin C status of the elderly.


Studies of the female bladder in old age. I. Cystometrograms in non-incontinent women.


Studies of the female bladder in old age. II. Cystometrograms in 100 incontinent women.


The development of pigment granules in the eyes of wild type and mutant Drosophila melanogaster. The eye pigment system in Drosophila melanogaster has been studied with the electron microscope. Details in the development of pigment granules in wild type flies and in three eye color mutants are described. Four different types of pigment granules have been found. Type I granules, which carry ommochrome pigment and occur in both primary and secondary pigment cells of ommatidia, are believed to develop as vesicular secretions by way of the Golgi apparatus. The formation of Type II granules, which are restricted to the secondary pigment cells and contain drosopterin pigments, involves accumulation of 60- to 80-A fibers producing an elliptical granule. Type III granules appear to be empty vesicles, except for small marginal areas of dense material; they are thought to be abnormal entities containing ommochrome pigment. Type IV granules are characteristic of colorless mutants regardless of genotype, and during the course of development they often contain glycogen, ribosomes, and show acid phosphatase activity; for these reasons and because of their bizarre and variable morphology, they are considered to be autophagic vacuoles. The 300-A particles commonly found in pigment cells are identified as glycogen on the basis of their morphology and their sensitivity to salivary digestion.


The effect of deprivation of glucose on the ultrastructure and function of the superior cervical ganglion of the rat in vitro. The superior cervical sympathetic ganglion of the rat kept in vitro in a bicarbonate-buffered Krebs' solution retains its capacity for synaptic transmission and axonal conduction during more than 36 hr. After glucose withdrawal, synaptic transmission is lost in 2(1/2) hr and this loss is irreversible; on the other hand, axonal conduction can still be measured on the postganglionic nerve for more than 24 hr after glucose deprivation. Electrophysiological measurements as well as electron microscope studies revealed specific changes at the level of the presynaptic terminal processes, while the ganglion cells and the satellite cells remained relatively unaltered. The presynaptic lesion due to lack of glucose can be prevented by keeping the preparation in vitro at 6 degrees C. This strongly suggests that this lesion results from a major disturbance of the metabolism of the presynaptic fibers.


Microtubules in relation to the motility of a sperm syncytium in an armored scale insect. Male scale insects of the species Parlatoria oleae Colvée (Homoptera: Coccoidea) produce motile sperm bundles. The bundle is a syncytium consisting of 10 to 20 closely packed, filamentous spermatozoa, which share a common cytoplasm and are enclosed in a common membrane. The individual spermatozoon is not surrounded by a plasma membrane, but is delimited by a scroll-like sheath composed of 45 to 50 microtubules. The microtubules run parallel to the long axis of the spermatozoon and are arranged in a spiral pattern as seen in transection. The outside diameter measures approximately 140 to 220 A and the inside diameter, 70 to 100 A. The spermatozoon is about 300 micro long and tapers gradually from a diameter of approximately 0.3 micro anteriorly to 0.1 micro posteriorly. The anterior half (150 micro) has a threadlike core of chromatin about 0.07 micro in diameter. A homogeneous cytoplasm surrounds the nuclear core and fills the posterior half of the spermatozoon. Neither osmium tetroxide nor glutaraldehyde fixation revealed the presence of a nuclear envelope, acrosomal membranes, mitochondria, flagellum, or centrioles. In spite of the apparent lack of orthodox cell organelles, the spermatozoon is actively motile upon release from the bundle. It exhibits capactiy for motility throughout its entire length. Since the sheath of microtubules is the only structure which extends the full length of the spermatozoon, it probably plays a significant role in spermatozoan motility.


Secretion of alpha-amylase by the embryonic chick pancreas in vitro. Pancreases taken from chick embryos secrete amylase in vitro when stimulated by cholinergic drugs. Rates of secretion increase with developmental age. The pancreas isolated together with the duodenal loop from the 8 day embryo is already capable of secretion in vitro. It is therefore concluded that the pancreas acquires the ability to secrete digestive enzymes more than 10 days before the beginning of the prominent biochemical and morphological changes associated with the maturation of the gland.


Microtubules and microfibrils in morphogenesis of the scale cells of Ephestia kühniella. The development of scale cells in insects has been studied from the appearance of the first cytoplasmic projection which forms the scale rudiment. This rudiment contains numerous longitudinally oriented microtubules throughout. Immediately under its outer surface lie a series of adjacent but distinct bundles of longitudinally oriented circa 60-A fibrils with a circa 120-A center-to-center spacing. As the rudiment broadens, the microtubules become distributed near the surface. The rudiment finally becomes extremely broad and flattened. Fibril bundles are now widely separated and equally spaced. They still lie immediately below the cell surface. Then the cytoplasm protrudes midway between each fibril bundle to form longitudinal ridges and the major shape changes of the scale have been achieved. The final pattern can thus be related to the cytoplasmic organization of the rudiment. The main cytoplasmic elements which seem important in scale morphogenesis, on the basis of frequency, orientation and grouping, are 60-A fibrils and microtubules.


Cytoplasmic granule formation in myelocytes. An electron microscope radioautographic study on the mechanism of formation of cytoplasmic granules in rabbit heterophilic myelocytes. The intracellular flow of tritiated lysine as revealed by electron microscope radioautography was studied in heterophilic myelocytes of rabbit marrow. Label over the Golgi complex rose to a maximum of 37% of total cytoplasmic grains 30 min after initial exposure to the tracer and fell to 11% after 3 to 4 hr of incubation. Coincident with decrease in label over the Golgi complex, grain counts over granules rose to 32% after 3 to 4 hr. The time sequence of incorporation and flow of tritiated lysine and the per cent distribution of label was similar in bone marrow myelocytes under in vivo and in vitro conditions. The results demonstrate a function of the Golgi complex in incorporating or packaging certain basic amino acids or proteins into cytoplasmic granules of heterophilic myelocytes.


The fine structure of Giardia muris.

The fine structure of Giardia muris. Giardia is a noninvasive intestinal zooflagellate. This electron microscope study demonstrates the fine structure of the trophozoite of Giardia muris in the lumen of the duodenum of the mouse as it appears after combined glutaraldehyde and acrolein fixation and osmium tetroxide postfixation. Giardia muris is of teardrop shape, rounded anteriorly, with a convex dorsal surface and a concave ventral one. The anterior two-thirds of the ventral surface is modified to form an adhesive disc. The adhesive disc is divided into 2 lobes whose medial surfaces form the median groove. The marginal grooves are the spaces between the lateral crests of the adhesive disc and a protruding portion of the peripheral cytoplasm. The organism has 2 nuclei, 1 dorsal to each lobe of the adhesive disc. Between the anterior poles of the nuclei, basal bodies give rise to 8 paired flagella. The median body, unique to Giardia, is situated between the posterior poles of the nuclei. The cytoplasm contains 300-A granules that resemble particulate glycogen, 150- to 200-A granules that resemble ribosomes, and fusiform clefts. The dorsal portion of the cell periphery is occupied by a linear array of flattened vacuoles, some of which contain clusters of dense particles. The ventrolateral cytoplasm is composed of regularly packed coarse and fine filaments which extend as a striated flange around the adhesive disc. The adhesive disc is composed of a layer of microtubules which are joined to the cytoplasm by regularly spaced fibrous ribbons. The plasma membrane covers the ventral and lateral surfaces of the disc. The median body consists of an oval aggregate of curved microtubules. Microtubules extend ventrally from the median body to lie alongside the caudal flagella. The intracytoplasmic portions of the caudal, lateral, and anterior flagella course considerable distances, accompanied by hollow filaments adjacent to their outer doublets. The intracytoplasmic portions of the anterior flagella are accompanied also by finely granular rodlike bodies. No structures identifiable as mitochondria, smooth endoplasmic reticulum, the Golgi complex, lysosomes, or axostyles are recognized.


A study of the nucleolar material in Sciara coprophila. In the polytene chromosomes of Sciara coprophila, in addition to a nucleolus, large numbers of nucleolarlike structures or micronucleoli are formed. A detailed mapping localized the nucleolar organizer at one end of the X chromosome and revealed that approximately 18% of the bands of each chromosome are potentially capable of producing micronucleoli. Most of these sites are in regions known from a previous study to show asynchronous DNA replication: DNA puffs and certain heterochromatic regions. Micronucleoli are rarely found in association with bulbs. The RNA metabolism of the polytene chromosomes during late fourth instar was studied using radioautographic techniques. Isolated glands were incubated in tritiated uridine for 10 to 30 min, and radioautographs were made of squash preparations. Despite the wide range of variation found among different larval cultures, the following pattern was observed. Just prior to and at the beginning of DNA puff formation, a period of intense extrachromosomal nucleolar and micronucleolar RNA synthesis occurs. After maximal development of the DNA puffs, the synthesis of extrachromosomal RNA is at a low point, while incorporation into bulbs and DNA puffs remains high. With the onset of the prepupal stage, all nuclear RNA synthesis ceases.


An unusual ciliumlike process.

An unusual ciliumlike process.


The synthesis of cytoplasmic DNA in synchronized Euglena.


Tubular connections between dictyosomes and forming secretory vesicles in plant Golgi apparatus.


A coat of repeating subunits on the cytoplasmic surface of the plasma membrane in the rectal papillae of the blowfly, Calliphora erythrocephala (Meig.), studied in situ by electron microscopy.


Human hepatic microbodies with crystalloid cores.


Temperature characteristics of excitation in space-clamped squid axons. Temperature characteristics of excitability in the squid giant axon were measured for the space-clamped axon with the double sucrose gap technique. Threshold strength-duration curves were obtained for square wave current pulses from 10 microsec to 10 msec and at temperatures from 5 degrees C to 35 degrees C. The threshold change of potential, at which an action potential separated from a subthreshold response, averaged 17 mv at 20 degrees C with a Q(10) of 1.15. The average threshold current density at rheobase was 12 microa/cm(2) at 20 degrees C with a Q(10) of 2.35 compared to 2.3 obtained previously. At short times the threshold charge was 1.5.10(-8) coul/cm(2). This was relatively independent of temperature and occasionally showed a minimum in the temperature range. At intermediate times and all temperatures the threshold currents were less than for both the single time constant model and the two factor excitation process as developed by Hill. FitzHugh has made computer investigations of the effect of temperature on the excitation of the squid axon membrane as represented by the Hodgkin-Huxley equations. These are in general in good agreement with our experimental results.


Active transport of D-xylose in the isolated small intestine of the bullfrog. Fluxes of D-xylose-1-C(14) (xylose) across the wall of the isolated intestine of the bullfrog were studied. When sodium was the principal cation in the mucosal bathing fluid, the transport rate of xylose from the mucosa to the serosa was about 5 times greater than the transport rate from the serosa to the mucosa, indicating an active intestinal transport for this sugar. With potassium as the principal cation on the mucosal side, the transport rate of xylose from the mucosal to the serosal compartment is reduced about 5 to 6 times without appreciable change in the serosal to mucosal transport. The asymmetry was also considerably reduced when ouabain was added to the mucosal and serosal compartments. The data confirm the in vitro and in vivo observations indicating active transport of xylose and are also in accord with the earlier findings that active transport of sugars in the intestine is dependent upon the presence of sodium ions in the mucosal compartment and is inhibited by cardioactive steroids. Since the chemical constitution of xylose does not meet the requirements which were hitherto considered necessary for active transport of sugars in the intestine, this structural requirement has to be revised.


Competitive action of calcium and procaine on lobster axon. A study of the mechanism of action of certain local anesthetics. Voltage clamp studies with the squid giant axon have shown that changes in the external calcium concentration (Frankenhaeuser and Hodgkin, 1957) shift the sodium and potassium conductance versus membrane potential curves along the potential axis. Taylor (1959) found that procaine acts primarily by reducing the sodium and, to a lesser extent, the potassium conductances. Both procaine and increased calcium also delay the turning on of the sodium conductance mechanism. Calcium and procaine have similar effects on lobster giant axon. In addition, we have observed that the magnitude of the response to procaine is influenced by the external calcium concentration. Increasing external calcium tends to reduce the effectiveness of procaine in decreasing sodium conductance. Conversely, procaine is more effective in reducing the membrane conductance if external calcium is decreased. The amplitude of the nerve action potential reflects these conductance changes in that, for example, reductions in amplitude resulting from the addition of procaine to the medium are partially restored by increasing external calcium, as was first noted by Aceves and Machne (1963). These phenomena suggest that calcium and procaine compete with one another with respect to their actions on the membrane conductance mechanism. The fact that procaine and its analogues compete with calcium for binding to phospholipids in vitro (Feinstein, 1964) suggests that the concept of competitive binding to phospholipids may provide a useful model for interpreting these data.


Geotropic response of wheat coleoptiles in absence of amyloplast starch. Young coleoptiles of wheat (Triticum durum var. Henry), depleted of amyloplast starch by incubation at 30 degrees C with gibberellin plus kinetin, retained their geotropic responsiveness. Depleted coleoptiles curved upward more slowly than controls, but this was commensurate with their slower growth. The ratio of curvature to growth was about 50 degrees per mm of elongation in both cases. Newly excised coleoptiles, though containing much more starch than incubated controls, curved only about 25 degrees per mm. The tissue treated in gibberellin plus kinetin appeared to contain no starch when examined (a) freshly squashed, (b) as fixed material sectioned thin and stained by the PAS procedure, and (c) as electron micrographs. Shrunken, starch-free amyloplasts could be identified in certain regions, but these did not show evidence of asymmetric distribution under the influence of gravity. The possibilities that other organelles function as statoliths are considered, and it is concluded not only that georeception is independent of starch grains, but further that it may not be due to statoliths at all in an ordinary sense.