Chromatography of nucleotides in extracts containing salts on layers of anionic, microcrystalline cellulose.


Inhibition of adrenaline action on liver dephospho-phosphorylase by borate.


Hydrazinolysis of alpha-1-acid glycoprotein.


The isolation of triacetic acid lactone from cultures of Penicillium patulum.


Binding of thyroid hormones by lysozyme: fluorescence quenching studies.


The amino acid sequence of the second component of clupeine.


Isolation and characterization of a metabolite of 1,1'-trimethylene bis(4-aldoximinopyridinium) dibromide.


I. Ophthalmoscopic and circulatory changes in focal retinal ischaemia.


Studies on the fragmentation of Nocardia erythropolis in liquid medium.


Induction and repression of endopolygalacturonase synthesis by Pyrenochaeta terrestris.


The utilization of tryptophan in the biosynthesis of echinulin.


Extracellular heteropolysaccharides from Cryptococcus and Tremella. A possible taxonomic relationship.


Electron microscopy of ultrathin sections of Micrococcus cryophilus.


Hyphal cell wall structure of two species of Pythium.


Hydrolysis products from an extracellular Tremella polysaccharide.


Biosynthesis of pteroic-acid-like materials by staphylococcus epidermidis.


Growth of Arthrobacter citreus at an elevated temperature. I. Promotion by associated microorganisms.


The iron tolerance test. Measurement of absorption and utilization of a therapeutic dose of iron.


Intracellular distribution of some enzymes in normal skeletal muscle.


Coeruloplasmin modifications by HNa2PO4 administration to rats bearing Jensen carcinoma.


Coeruloplasmin modifications by HNa2PO4 administration to O-Ya ascitogen tumor-bearing rats.


An automated method for the determination of serum 5'-nucleotidase.


The nature of the lactate dehydrogenase isoenzymes in human placenta and related tissues.


Spectrophotometric determination of urinary copper.


A rapid semi-quantitative test for diacetic acid in blood and urine.


Clinical enzyme units.

Clinical enzyme units.


The determination of free and esterified cholesterol in blood after separation by thin-layer chromatography.


A fluorimetric procedure for the determination of ketone bodies in very small quantities of blood.


Improved gradient elution for the separation of urinary steroid conjugates on DEAE-Sephadex columns.


Osteomalacia following ureterosigmoidostomy, with observations on bone morphology and remodeling rate.


Thickness of osteoid seams in some diseases of man.


Bone histodynamic changes in the rheumatic diseases.


Tetracycline-based measurement of bone dynamics in 3 women with osteogenesis imperfecta.


Bone tissue and cell dynamics determined by tetracycline labeling in a case of pseudohypoparathyroidism (and in the patient's mother).


Development of structure and function in the mammalian yolk sac. I. Developmental morphology and vitamin B12 uptake of the rat yolk sac.


Development of structure and function in the mammalian yolk sac. II. Vitamin B12 uptake by rabbit yolk sacs.


Cytodifferentiation and embryogenesis in cell colonies and tissue cultures derived from ova and blastocysts of the rabbit.


Juxtamalleolar lipomata.

Juxtamalleolar lipomata.


Development of structure and function in the mammalian yolk sac. 3. The development of amino acid transport by rabbit yolk sac.


Morphogenesis in Nicotiana debneyi-tabacum, N. longiflora and their tumor-forming hybrid derivatives in vitro.


Tumor autoimmunity against methylcholanthrene-induced sarcomas of the rat.


Experimental production of the clone with atypical multiplication from synchronous cultures of Tetrahymena pyriformis GL treated with 4-nitroquinoline 1-oxide.


Fractures of the dorsal and lumbar spine.


Skeletal changes in aging and disease.

Skeletal changes in aging and disease.


Biochemical changes in tumor cells caused by antitumor agents. II. Effect of several antitumor agents in vivo and in vitro on beta-glucuronidase and two other lysosomal enzymes of Yoshida sarcoma cells.


Exchangeable bone calcium.

Exchangeable bone calcium.


Cortical bone dynamics in osteomalacia, measured by tetracycline bone-labeling.


Bio-assay of responses of growing bones to cortisol.


On a form of chronic inflammation of bones. (Osteitis deformans).


Osteoid osteoma. (Roentgenographic emphasis).


Relation between bone tissue and cell population dynamics, histology and tetracycline labeling.


Tetracycline-based measurement of the tissue and cell dynamics in rib of a 25-year-old man with active acromegaly.


Effect of lengthening the Achilles tendon on the strength of gastrocnemius-soleus musculature.


Growth-inhibiting substance prepared from human leiomyosarcoma.


Acid phosphatase activity and its distribution between particles and cell sap at early stages of rat liver regeneration.


Biological studies of anticancer agents. II. Effect of percutaneous application.


A quantitative histologic study of the effects of fluoride on resorption and formation in animal and human bone.


Induction of lung cancer and leukemia in the adrenalectomized or gonadectomized rats by the injection of 4-nitroquinoline 1-oxide.


In vitro effect of glucose of viability and transplantability of Ehrlich ascites tumor cells.


The activity of phosphorylase and the effect of glucagon on the yolk sac of the chick embryo.


The effects of estradiol-17 beta and/or progesterone on nitrogen balance values in studies on the castrated rooster.


The metabolic response to thyroxine of lizards maintained in a thermal gradient.


MSH activity in pituitaries of rats treated with hypothalamic extracts.


Fine structure of the neurohemal areas associated with the hypophysis in the hagfish, Polistotrema stoutii.


On the response of the endostyle of the hypophysectomized larval lamprey to thiourea.


Influence of thyroxine and steroid hormones on spontaneous and evoked unitary activity in the olfactory bulb of goldfish.


Examination of the evidence for neurosecretion in the nervous system of Helisoma tenue (Gastropoda Pulmonata).


The pituitary of the African lungfish Protopterus sp.


Evaluation of isotope separation factor for 1-C14 lysine on exchange resins with carboxylic groups.


A new quantitative external monitoring technique.


Computer code for reduction of coincidence counting data.


Transfer of EU152-4 to the offspring during pregnancy and lactation.


Purity control of palladium and gold targets used for production of radioisotopes.


Fast neutron dosimetry by anion exchange separation of Caesium-137 from irradiated thorium.


Labelled chromium sesquioxide as a marker for digesta: preparation and quantitative determination in faeces.


The single-well method for determining the direction of flow of ground-water using a neutron source.


A programmed analysis for the counting of aqueous samples containing two radioactive isotopes.


A simple technique for the hydrogenation of ethylene.


Production of carrier-free I-131-iodate.


The assay of beta-emitting radioisotopes using Cerenkov counting.


The effect of irradiated, low temperature, high pH water on nylon.


New oxygen flask apparatus for the assay of tritium and carbon-14.


The gamma radiation of Br83.

The gamma radiation of Br83.


Measurement of the decay scheme correction in the absolute standardization of cobalt-57.


Two bacterial enzymes hydrolyzing oligomers of 6-aminocaproic acid.


Photooxidation of adenine and its nucleotides in the presence of riboflavin. II. Photochemical reaction of adenine and its photoproducts.


Photooxidation of adenine and its nucleotides in the presence of riboflavin. 3. Photooxidation of CoA and ATP.


Hemoglobin biosynthesis in the chicken red blood cells and inhibitory effect of actinomycin D.


Biochemistry of shellfish lipid. 3. Purification and elemental analysis of ceramide aminoethylphosphonate from Corbicula complex lipid mixtures.


Enzymatic activity of polyalanyl ribonuclease T and polyglutamyl ribonucleaseT.


Isolation of uridine diphosphate N-acetyl-D-glucosamine from Streptomyces griseus.


A simple colorimetric estimation of lipids with sodium dichromate.


Synthesis of a cyclic hexapeptide designated as gramicidin J2.


Fiber degeneration after lateral hypothalamic lesions in the rat.


Nervous system of the snail Helix aspersa. I. Structure and histochemistry of ganglionic sheath and neuroglia.


The postnatal development of neocortical neurons in the dog.


Relationship of cortico-spinal tract growth to age and body weight in the rat.


Ponto-sacral connections in the medial reticulo-spinal tract subserving storage of urine.


An experimental study of the spino-olivary fibers in the rabbit and the cat.


The localization, in the nucleus ambiguus of the rabbit, of the cells of origin of motor nerve fibers in the glossopharyngeal nerve and various branches of the vagus nerve by means of retrograde degeneration.


The nucleus ambiguus of the rabbit.

The nucleus ambiguus of the rabbit.


Amino acid composition of 6 distinct types of beta-casein.


Distribution and characterization of antipenicillin activity in cheese.


Dietary fat levels and carbohydrate and fat metabolism in calves.


The thyroid and the development of the nervous system in Eleutherodactylus martinicensis: an experimental study.


A reinvestigation of some of the tissue movements involved in the formation of the neural tube and the eye/lens system of Triturus alpestris and Xenopus laevis.


Experimental evidence for the nuclear control of differentiation in Micrasterias.


Effects of temperature on reptilian and other cells.


Thyroid growth and its relationship to metamorphosis in Rana temporaria.


The development of the chick embryo diencephalon and mesencephalon during the initial phases of neuroblast differentiation.


More about the tabby mouse and about the Lyon hypothesis.


An isolated insect ganglion-nerve-muscle preparation.


Functioning of the inhibitory conditioning axon innervating insect muscles.


Proprioceptive control of posture in the crayfish abdomen.


The hormonal control of the development of hairs and bristles in the milkweed bug, Oncopeltus fasciatus, Dall.


The function of haemoglobin in relation to the maintenance of neutral buoyancy in Anisops pellucens (Notonectidae, Hemiptera).


Studies of the cleavage in the frog egg. I. On the temporal relation between furrow determination and nuclear division.


The motion of Euglena viridis: the role of flagella.


Activity of interneurones in the arm of Octopus in response to tactile stimulation.


Comparison of hemoglobin quantities in two inbred strains of mice and reciprocal hybrids.


Physicochemical studies of Newcastle disease virus. II. Chemical distribution of 32P in the virus labeled with 32P and base composition of the viral RNA.


Studies on experimental radiation injury in mice by internal Strontium-90. 3. Effects of internal 90Sr on calcium and phosphorus metabolism in bone and some organs.


Spontaneous liberation of infective larvae from the earthworm, Eisenia foetida, infected with Metastrongylus apri.


Reading readiness studies: suspect first graders.


Time-motion study of practicing pediatricians.


Daydreaming and planful thought: a note on Professor Stark's conceptual framework.


Progress direction and psychological time.


Smith and Smith's developmental studies on spatial judgments: a note.


Fragmentation phenomena in luminous designs.


Generality of psychological processes and specificity of outcomes.


Case studies in behavioral research in rehabilitation.


Credibility of source and recipient's attitude: factors in the perception and retention of information on smoking behavior.


Sex characteristics in personality patterns of elementary school teachers.


Cross-modal matching of histograms and four-component taste mixtures, with one component fixed, under two pacing conditions.


Serial order as a unique source of error in running memory.


Electrocardiogram changes in prolonged automobile driving.


Extravisual plasticity of posterior cortex in rats as a function of variations in proximal and distal input during development.


SLD and motor training.

SLD and motor training.


Some comments on Wohlwill's critique.

Some comments on Wohlwill's critique.


Australid environment--external and internal.


A new dynamic balance testing device: the "dynabalometer".


A test of the existence of monocular stereoscopic depth perception.


Note on use of information concepts in the assessment of group structure.


Studies in sequential perception: looking at one thing but finding another.


Preference for subordinating or superordinating and creativity in engineers, scientists, designers, and artists.


Some effects of light on sound intensity generalization as a function of number of training trials.


Decoding of electrocutaneous signals: effects of dimensionality on rates of information transmission.


Serial verbal learning as a joint function of amount of practice and individual differences.


Auditory-visual integration, intelligence and reading ability in school children. Reply to Sterritt and Rudnick.


Implications of symmetry about a regression line.


Effects of load-carrying on psychomotor performance.


Model for effect of a second visual stimulus upon reaction time to the first.


Feasibility of measuring eye movements in real-world and simulated driving situations.


Bender recall of children as related to age and intelligence.


Personality characteristics of converted left handers.


Anxiety in a patient with bilateral hip disarticulation: preliminary report.


A taxonomic analysis of continuous performance.


Effect of resistance through a throwing range-of-motion on the velocity of a baseball.


Subjective estimate approach to scaling attitude statements.


Psychology of the scientist. XV. Level of research interest, status, and organizational factors in the academic environment: preliminary study.


Australid mental development and geriatric decline.


Monocular testing: a methodological note on eidetic imagery.


Intra-subject stability of isolation tolerance.


Effect of unilateral above-the-knee amputation on perception of verticality.


Further study of guided learning experience in developing probability concepts in grade five.


A contribution to the study of the significance of autoantibody detection for diagnosis of liver injury.


Duodenal biopsy in chronic pancreatitis.


Isolation and structure of aflatoxins M1 and M2.


Treatment of chronic protozoal intestinal diseases with intestopan.


Failure of antibody production to yellow fever vaccine in children with kwashiorkor.


Associated factors in kwashiorkor in Uganda.


Smallpox vaccination in malnourished children.


Geographical distribution and clinical significance of human coccidiosis.


Isolation of arboviruses of group A and group C in Surinam.


A study of beliefs and attitudes towards food in a New Guinea Low-Cost Housing Settlement.


Natality and marital infertility in Ghana.


Human infertility in West Africa.

Human infertility in West Africa.


Chronic pancreatitis with calcifications in Congolese Bantus.


Variation in the modal chromosome number of two PK-15 porcine kidney cell lines.


Chromatolysing spinal neurons in the chick following tricresylphosphate (TCP) intoxication.


Further observations on the neurotoxicity of organophosphorus compounds.


Histological observations on the evolution of nutritional encephalomalacia in chick cerebellum.


Neurofibrillary degeneration of nerve cells after intracerebral injection of aluminium cream.


The influence of analgesic antipyretic drugs on the responses of guinea-pig lungs to bradykinin.


Proteolipids and proteins in subcellular particles of human brain.


Cholesterol content in cerebrospinal fluid of hydrocephalus.


A double-stage type apparatus for vertical gel electrophoresis.


Metabolism of aromatic amino acids in collagen diseases. Urinary excretion of metanephrine and normetanephrine, and spontaneous degradation of vanilpyruvic acid.


Histidase and urocanase activities of liver and plasma. Correlations between tissue enzyme levels and plasmatic increases during human and mouse viral hepatitis.


Studies on human pancreatic lipase.

Studies on human pancreatic lipase.


A new sensitive chemical test for the detection of occult blood in faeces and in urine with dietary restrictions.


127-I-iodotyrosine-like compounds in normal human serum.


Comparison of precision of the Ness method for serum total cholesterol with a ferric chloride method.


Short-term feeding study with diethylene glycol monoethyl ether in rats.


Carcinogenicity and toxicity tests of hexamethylenetetramine in mice and rats.


ERG in diseases.

ERG in diseases.


Long-term study of Ponceau MX in rats and mice.


Gougerot-Sjogren syndrome treated with parotid duct transplantation.


Early changes at the site of repeated subcutaneous injection of food colourings.


Diagnostic ultrasonography in ophthalmology.


Adenocarcinoma of Meibomian glands (report of 2 cases).


Carcinogenicity of certain glycidyl derivatives.


Craniofacial dysostosis.

Craniofacial dysostosis.


Vogt-Koyanagi syndrome with optic neuritis.


Osteoma of the orbit.

Osteoma of the orbit.


Granules associated with the chloroplast lamellae of Porphyridium cruentum. Small granules with a diameter of approximately 350 A are attached to the chloroplast lamellae of the red alga Porphyridium cruentum. To some extent, their size depends on the culture conditions and the age of the cell. It was possible to preserve the granules only with aldehyde prefixation. It can be seen that fixed or negatively stained granules are comprised of smaller subunits. The granules are arranged regularly on the lamellae in repeating rows with a center-to-center granule distance of 400 to 500 A. Attempts at characterization of these chloroplast granules revealed that they are resistant to hydrolysis by ribonuclease and appear to be structurally unaffected by methanol-acetone extraction. Because of their close association with the chloroplast lamellae, they are considered as possible sites of phycobilin concentration. This possibility is supported by two observations: when the phycobilins are removed, the granules disappear; and, when the chlorophyll and stainable membrane portions are selectively removed, the phycobilins and granules are still present. It was found that all other marine red algae examined had granules which were associated with the chloroplast lamellae.


Relationship between RNA synthesis, cell division, and morphology of mammalian cells. I. Puromycin aminonucleoside as an inhibitor of RNA synthesis and division in HeLa cells. Logarithmically growing HeLa cell monolayers were treated with a range of concentrations of puromycin aminonucleoside (AMS). The effects of AMS were studied by the following means: microscope examination of treated cells; enumeration of the cell number using an electronic particle counter; analyses for DNA, RNA, and protein content; incorporation of P(32) and H(3)-thymidine into nucleic acids; and fractionation of nucleic acids by column chromatography. Taking the rate of incorporation of the isotopic precursor as a measure of nucleic acid synthesis, it was found that concentrations of the inhibitor which had a rapid effect on the rate of cell division inhibited the synthesis of all types of nucleic acids and of protein, but depressed ribosomal RNA synthesis most markedly. Lower concentrations of AMS selectively inhibited ribosomal RNA and, to a lesser extent, transfer RNA synthesis. Partial inhibition of ribosomal RNA synthesis with low doses had no effect on the rate of cell division within the period studied (3 generation times). The cell content of RNA returned to normal when the inhibitor was removed.


The flame cell of rotifer. Electron microscope observations of supporting rootlet structures.


Fine structural localization of acetylcholinesterase in electroplaque of the electric eel. The electroplaques composing the electric organ of the eel, Electrophorus electricus, have been utilized for the dual purpose of demonstrating the subcellular sites of acetylcholinesterase activity and as a model for comparison of the several cytochemical methods available. Fresh tissue and tissue fixed by immersion in formalin, hydroxyadipaldehyde, or glutaraldehyde was reacted with the Cu-thiocholine method, the Cu-ferrocyanide thiocholine method, or the thiolacetic acid (TAA) method using Pb, Ag, or Au as capture reagents. Controls were obtained by omission of substrate, or by addition to complete media of varying concentrations of different cholinesterase inhibitors. Reactions were run at 0-5 degrees C at a pH range of 5.0-7.1 for 0.25 to 120 min. Regardless of the capture metal, the localization obtained with TAA as substrate was identical with that observed with acetylthiocholine, the majority of precipitate being deposited on or near the external innervated surface of the plaque and within the tubulovesicular organelles opening onto the innervated surface. Both of the thiocholine methods and the Pb-TAA method showed reaction product in synaptic vesicles of the nerve endings innervating the plaque which was uninhibitable by 10(-4)M physostigmine. All methods also showed some inhibitor-sensitive deposition of reaction product in the mucoid material forming the immediate extracellular environment of the innervated surface.


A simple freeze-fracture replication method for electron microscopy. A simple method to achieve results similar to the freeze-etching technique of Moor et al. (1961) is described. The frozen tissue is cut under liquid nitrogen with a razor blade outside the evaporator rather than inside with a cooled microtome. The conditions of the experiment do not favor sublimation, and it is proposed that the structure of the replica be explained by local faults in the cleavage plane which leaves structures, such as membranes, standing above the ice. Micrographs of replicas of glycerol-protected frozen small intestine of mouse prepared by the method are presented and the structural details they show are discussed. The problem of vapor-deposited contamination is discussed. It is concluded that this is a practical method for obtaining electron micrographs that are relatively free of artifact, and that further improvements may be expected from the use of rapidly frozen fresh tissue and a clean vacuum system, possibly of the ion-pumped type.


Punishment as a discriminative stimulus and conditioned reinforcer with humans. Mental hospital patients were reinforced for responding in a two-response operant situation. When a noise was used to punish one of the responses, all subjects shifted to the unpunished one. When the noise was then paired with positive reinforcement, the subjects responded to produce the noise. Also, a novel response was reinforced by noise in the absence of other reinforcers. This study with humans extends the findings of previous studies with animals in revealing how a punishing stimulus can acquire discriminative or conditioned reinforcing properties.


Limb regeneration and nerve fiber number in Rana sylvatica and Xenopus laevis.


The stomach cell of rotifer. Electron microscope observations of the terminal web.


Association of neutral objects with rewards: effects of reward schedules on reward expectancy, verbal evaluation, and selective attention.


Quantitative study of mitochondria in rat liver. Dry mass, wet mass, volume, and concentration of solids. The dry mass, wet mass, and volume of mitochondria of normal rat liver were determined, as well as nitrogen content and concentration. A scheme of multiple approaches to these quantities was devised, permitting comparison of values obtained by independent methods. The following basic values are considered highly accurate: Mean dry mass, 13.6 x 10(-14) g; mean wet mass, 51.8 x 10(-14) g; mean volume, 0.43 micro(3); nitrogen content, 1.75 x 10(-14) g The work emphasizes the fact that in mitochondria the quantities, mass, and volume occur in logarithmic-normal distributions.


The stability and control of conditioned noise aversion in the tilt cage. Twenty-six rats were used to study the development of stable conditioned responding to terminate white noise (100 or 105 db) in a tilt cage apparatus. Preliminary work, with one end of the cage consistently associated with silence, demonstrated stability at a high level of cumulative noise-off time per session. Time spent at the noise-off cage end was unaffected by lay-off and showed adaptation to reversal of the cage end functions. Variability in reversal acquisition, insensitivity to stimulus intensity changes and persistence in remaining at one end of the cage in the absence of noise-termination contingencies indicated the need for more precise behavioral control. A schedule programming several reversals of the no-noise end at variable intervals within each session was developed. Performance on the latter schedule was characterized by stability of high noise-off times and also proved more sensitive than the preliminary method to stimulus intensity changes (55, 70, 100 db) as measured by both cumulated noise-off time and cage crossing rates. The ease of training combined with sensitivity to stimulus change and the lack of highly specific motor response requirements make this technique promising for use with animals potentially debilitated by drugs or surgical after-effects.


On the application of immunological techniques in geographic group studies of Atlantic sea herring, Clupea harengus. I. Neutralization of immune precipitins as an aid to herring serum analysis by immunoelectrophoresis.


A quantitative comparison of the growth of the embryonic chick tibiotarsus in vivo and in vitro.


Studies in aging. II. The effects of injecting hemolymph from younger and older donors on the fecundity and the adult life span of hosts in Drosophila.


The influence of neural retina and lens on the development of embryonic lens vesicles in Amblystoma punctatum and Triturus viridescens.


The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.


Xanthine oxidase from liver and duodenum of the rat: histochemical localization and electrophoretic heterogeneity.


Congenital malformations observed in 12146 births at the American University Hospital in Beirut.


Reaching out for new dimensions.

Reaching out for new dimensions.


Malignant Brenner tumor.

Malignant Brenner tumor.


Chemico-physical studies on water of living tissues; with special reference to normal, degenerated and regenerated rabbit's sciatic nerve. I.


Some biological aspects on the preputial gland of the female rat.


Electron microscopic study of dermal capillaries in diabetes mellitus.


The fate of the homogenous enzymes in rat body. On the organo-affinities of beta-glucuronidase.


Correlations between plasma renin, hematocrit and natriuresis.


Anemia in chronic liver disease.

Anemia in chronic liver disease.


Sarcoidosis: a case report with pulmonary function studies before and after treatment with corticosteroids.


Testosterone metabolism by human male mammary skin. I.


16-Beta-hydroxymethyl- and 16-beta-formyl-D-nor-4-androsten-3-one.


The anhydrous solvolyses of 5-beta-cholestan-3-beta, 5-diol-6-one 3-p-toluenesulfonate.


An assay for progestagens by the intravenous route.


Cholesterol analogues with oxa- and oxa-aza side chain. A novel class of inhibitors of cholesterol biosynthesis.


Steroid conjugates I. The use of sulfamic acid for the preparation of steroid sulfates.


Youth exchange.

Youth exchange.


Compendium of normal blood values of laboratory animals with indication of variations. I. Random-sexed populations of small animals.


The in vitro activity of supona against ticks.


Advisory structures within the animal feeding-stuffs industry. II.


Advisory structures within the animal feeding-stuffs industry. 3.


An explanation for the reduced frequency of double lysogenization.


Isolation of respiratory syncytial virus from middle ear exudates of infants.


Acetylcholinesterase activity in the efferent cochlear fibres after destruction of the organ of corti and afferent fibres.


The physical parameters of cough: the larynx in a normal single cough.


Effect of orientation to the gravitational vertical on nystagmus following rotation about a horizontal axis.


Effects of unilateral warm and cold water irrigation in the outer ear of rabbits on isolated nerve cells from the lateral vestibular nucleus and cerebellum.


The effect of physostigmine on the latency of the cochlear potentials.


In search of tonic cervical reflexes. An evaluation of Fukuda's vertical writing test.


The mechanism of alpha-oxidation in leaves.


The effects of thyroxine on the pattern of fatty acid synthesis in rat liver.


The effect of insulin on monounsaturated fatty acid synthesis in diabetic rats. The stability of the informational RNA and of the enzyme system concerned with fatty acid desaturation.


Phospholipids of yeast. II. Extraction, isolation and characterisation of yeast phospholipids.


Diol lipids.

Diol lipids.


Sulfatides of human kidney. Isolation, identification, and fatty acid composition.


The isolation and partial characterisation of the glycolipids from pig lung.


Esterification of cholesterol by rat adrenal gland homogenates and subcellular components.


Calcium action on fatty acid and phospholipid monolayers and its relation to the cell membrane.


Alkoxylipids. I. Preparation and characterization of alkoxy-diglycerides and dialkoxy-glycerides.


Acyl group exchange in the intestinal lumen during fat digestion.


Fatty acids of the "red tide" organism, Gonyaulax polyedra.


Isolation from beef-heart homogenate of a particulate lipoprotein containing beta-carotene.


The metabolism of elaidic acid in the perfused rat heart.


Metabolism of deoxyinosine by human erythrocyte ghosts.


Increased content of high molecular weight RNA fractions in nuclei and nucleoli of livers of thioacetamide-treated rats.


Insulin-stimulated ribonucleic acid synthesis and RNA polymerase activity in alloxan-diabetic rat liver.


Regulation of nucleic acid synthesis in Lactobacillus acidophilus R-26.


Actinomycin D and p-fluorophenylalanine, inhibitors of nuclear replication in HeLa cells.


Protein synthesis in growing-rat tissues. II. Polyribosome concentration of brain and liver as a function of age.


Protein synthesis in growing rat tissues. I. Effect of various metabolites and inhibitors on phenylalanine incorporation by brain and liver ribosomes.


Biosynthesis of malformin in washed cells of Aspergillus niger.


Polyribosomal patterns in rat liver after the administration of 3-methylcholanthrene.


Preparation of polysomes from rat brain tissue.


Methylation and secondary structure of polyadenylic acid.


Some properties of isolated nucleoli from guinea-pig liver.


The stimulation in vitro of protein synthesis in muscle microsomal supernatant by estradiol-3,17-beta-disulfate.


Meniscal resistance in tube viscometry.

Meniscal resistance in tube viscometry.


Mechanism of fiber formation by the silkworm, Bombyx mori L.


The rheology of DNA solutions.

The rheology of DNA solutions.


On the significance of the Reynolds Number in blood flow.


The physician-patient and psychiatry.

The physician-patient and psychiatry.


Validity in mental health surveys.

Validity in mental health surveys.


One-year follow-up of 67 chronic psychiatric patients.


Readmission experiences of a cohort of discharges 1953-1957. Cohort followed for five years from date of discharge.


Major changes in the administration of psychiatric services in Canada.


Reversed potentials in isolated frog skin. II. Active transport of chloride.


Membrane permeability changes in amphibian eggs at ovulation.


The metabolism of L-glutamate and L-5-carboxy-pyrrolidone by mouse cells (NCTC clone 929) under conditions of defined nutrition.


The effect of phytohemagglutinin on glucose-U-C14 oxidation by peritoneal and blood white cells of the rat.


Isolation and characterization of an isoantigenic variant from a heterozygous mouse lymphoma in culture.


The glyceride fatty acid composition and lipid content of brown and white adipose tissue of the hibernator Citellus lateralis.


Experimental Coxsackie B-3 virus infection in Citellus lateralis.


Response of cultured chick heart cells to changes in ionic environment.


Effect of thermal conductance on water economy in the antelope jack rabbit, Lepus alleni.


Circadian activity rhythms in cockroaches. 3. The role of endocrine and neural factors.


Transport of sugars into human red blood cell ghosts.


Effect of radiophosphorus decay on cistron function in bacteriophage T4. II. Stabilization to inactivation during phage growth.


RNA of low molecular weight in KB cells infected with adenovirus type 2.


Interaction of poly-L-proline with lithium bromide.


Isolation and characterization of DNA from the mitochondrial fraction of Euglena.


Protein synthesis by cell-free extracts of tobacco leaves. 3. Comparison of the physical properties and protein synthesizing activities of 70 s chloroplast and 80 s cytoplasmic ribosomes.


Papain fragmentation of rabbit gamma-g-globulin: a crystallographic study.


Electron microscopy of ribosomes isolated from tobacco leaves.


Simultaneous diffusion and reaction of azide in a cylindrical crystal of ferrimyoglobin.


Multiple active varieties of Neurospora glutamate dehydrogenase formed by hybridization between two inactive mutant proteins in vivo and in vitro.


Mnemonic organization as a determinant of error-gradients in visual pattern perception.


Conformity of perception of figure inversion in children.


Need for novelty and occupational preference.


Approach of domestic chicks to stationary objects of different texture.


Simulation of strabismus: motor fusion as a function of speed of monocular alternation.


Clinical anxiety and conformity.

Clinical anxiety and conformity.


Presentation of laboratory experiments through motion picture films.


Personality variables in autokinetic figure writing.


Defense and control: further indications.


Laborimeter performance of intellectually normal and subnormal children during learning and retesting.


A quantitative study of relevance in the formation of adaptation levels.


Toward a taxonomy of automobile driving. I. Tracking.


Retention of verbal materials perceived immediately prior to onset of non-REM sleep.


Pain reactivity and kinesthetic aftereffect.


Assessment of perceptual-motor changes following electroshock treatment.


Black-white color connotations and racial awareness in preschool children.


Note on intellectual changes in multiple sclerosis.


Comparison of delinquents and nondelinquents on the IES test.


The intellectual profile of retarded readers.


Stimulus equivalence of auditory and visual patterns in an intermodal discrimination task.


Response rate and subjective estimates of attitude statements.


Analysis of perspective reversal and associated apparent motions using a perspective-bound movement illusion.


Auditory and visual rhythm perception in relation to reading ability in fourth grade boys.


Dimensions of interpersonal perception in a meaningful ongoing group.


Lateral dominance and reading ability.

Lateral dominance and reading ability.


Conceptualizations of the college teacher.


Conceptual retraining of brain-damaged adults.


Stimulus discrimination through intracranial reinforcement.


Interrelations among measured and perceived psychosocial variables.


Comparison of scaling methods: paired comparisons versus constant-sum.


Color coding and potency of anchors and residuals in judgment of size.


Auditory awakening thresholds in REM and NREM sleep stages.


Effect of instructions on a creative task: discipline and form in hand sculptures.


Symbol identification as a function of misregistration in color additive displays.


An apparatus for measuring freely operant behavior chains.


Judging of cleft palate and normal neonatal cries.


Perception of shape as a function of order of angles of slant.


An experimental study of visual perceptual training and reading achievement in first grade.


Sex differences in perceptual motor development.


The dramatic sibling.

The dramatic sibling.


Hypnosis in treatment of alcohol addiction. Controlled trial, with analysis of factors affecting outcome.


Effect of congeners in alcoholic beverages on the incidence of nystagmus.


The development, major goals and strategies of a skid row program: Philadelphia.


Identifying alcoholics in population surveys. A report on reliability.


Demographic characteristics of tavern patrons in San Francisco.


Occurrence of unusual pleural calcification in Finland. Studies on atmospheric pollution caused by asbestos.


Abstract biological systems as sequential machines. 3. Some algebraic aspects.


A note on replication in (M,R)-systems.

A note on replication in (M,R)-systems.


Abstract biological systems as sequential machines: behavioral reversibility.


On multipole theory in electrocardiography.


Ventricular septical defect with bidirectional shunting: mathematical considerations.


Some multi-dimensional branching processes as motivated by a class of problems in mathematical genetics II.


A resolution of Rosen's paradox for self-reproducing automata.


Control of the contractility of the myocardium in a feedback system.


On the shape of a DNA molecule.

On the shape of a DNA molecule.


A note on group ring expression of self-fertilized population.


A population growth model incorporating delayed responses.


Reconstruction of protein and nucleic acid sequences. IV. The algebra of free monoids and the fragmentation stratagem.


Analysis of tracer experiments. VII. General multi-compartment systems imbedded in non-homogeneous inaccessible media.


A note on relations between sets.

A note on relations between sets.


Physics, biology, and sociology: a reappraisal.


The development of the pituitary in Xenopus laevis Daudin.


The incubation patch of the house sparrow, Passer domesticus Linnaeus.


Further data relating to the maturation hormone and its site of secretion in Arenicola marina Linnaeus.


A re-examination of the goldfish microhistometric assay method for thyrotropin.


The nucleus preopticus in the hypothalamus of the platyfish (Xiphophorus maculatus).


Histochemistry of the A cell neurosecretory material in the milkweed bug, Oncopeltus fasciatus Dallas (Heteroptera: Lygaeidae), with a discussion of the neurosecretory material-carrier substance problem.


Maintenance of thyroid function in newts with transplanted pituitary glands.


The effects of exposure to darkness on the reproductive and hypothalamo-hypophysial systems of Budgerigars, Melopsittacus undulatus.


Effects of pharmacological agents on the hypothalamus of Rana pipiens in relation to the control of skin melanophores.


Mitotic activity in the lumbosacral spinal cord of Rana pipiens larvae after thyroxine or thiourea treatment.


Evidence of a negative feedback on photoperiodically induced gonadal development in the white-crowned sparrow, Zonotrichia leucophrys gambelii.


Hypothalamo-hypophysial vascular and neurosecretory links in ratfish, Hydrolagus colliei (Lay and Bennett).


Morbidity pattern of the South Indian adolescent.


Osteopetrosis (Albers-Schonberg's Disease). Report of three cases in one sibship.


Hemimelia with multiple visceral anomalies and eventration. Report of a case.


The various quenching effects in thin-layer chromatography. Application to air pollution.


An improved spray reagent for detecting lipids on thin-layer chromatograms.


Gas chromatography of N-chloroethyl and N,N-bis-(chloroethyl) carbamates.


Electrophoresis and detection of proteins on thin layers of alumina.


Hereditary contractures of the fingers (camptodactyly).


Turner's syndrome in monozygotic twins.

Turner's syndrome in monozygotic twins.


An XO-X ring X chromosome mosaicism in an individual with normal secondary sexual development.


An unstable ring chromosome in a female infant with hypotonia, seizures, and retarded development.


Klinefelter's syndrome with a presumptive deleted X chromosome.


13-15 trisomy mosiacism in a normal-looking 14-year-old retarded girl.


Oral-facial-digital syndrome, with polycystic kidneys and liver: pathological and cytogenetic studies.


Hypertrichosis terminalis with simian characteristics.


Epiloia (tuberous sclerosis): a report of a case with unusual tumours.


Congenital asymmetry.

Congenital asymmetry.


A family study of the late infantile and juvenile forms of metachromatic leucodystrophy.


Chromosome studies in familial leukaemia.


Choice of antimicrobials in the treatment of diarrheas in children.


Syndromes of pharyngitis in Filipinos. (Comparison of four antibiotics on an out-patient basis).


Mechanisms of leukocyte production and release. VI. Studies on the purification of the leukocytosis-inducing factor (LIF).


Metabolism of cholesterol in reticuloendothelial hyperfunctional rats maintained on normal or high cholesterol diets.


Spleen development in mice of high- and low-leukemic strains.


Structural abnormalities of the Y chromosome in man.


Chemical coupling of enzymes to cross-linked dextran ('Sephadex').


Dynamic aspects of growth and metabolism in Candida utilis.


Efficacy of 'Viractin' in preventing respiratory disease.


Experimental amyloidosis and tolerance.

Experimental amyloidosis and tolerance.


Effects of irradiation on synthesis of deoxyribonucleic acid and mitosis in synchronous cultures of HeLa cells.


Memory and spontaneous alternation in the rat.


Bone lysozyme: partial purification, properties and depression of activity by parathyroid extract.


Active copper transport in mammalian tissues--a possible role in Wilson's disease.


Isolation of delta-7-cholesten-3-one from butterfat.


Effect of human growth hormone on 'insulin basic protein complex'.


pH dependence of lactate dehydrogenase isozyme inhibition by substrate.


Release of acetylcholine from the cerebral cortex during stimulation of the optic pathway.


Hypoglycaemia, elevated liver glycogen and diminished liver amylase in pancreatectomized-enterectomized dogs.


Inability of the electroretinogram to recover after a brief, high-intensity light stimulus.


Adrenergic beta-receptors and non-shivering thermogenesis.


Destruction of cephalosporin C by ultra-violet light.


Blood platelets as a source of enzyme activity in washed trypanosome suspensions.


Antibody inhibition by a minimal dose of antigen and response to a sudden increase of the dose.


Effect of immunosuppression on first-generation isotransplantation of chemically induced tumours in mice.


Centron-cortex and cortex-medullary cord junctions in the rat lymph node, as seen in 1 micron paraffin sections.


Further evidence of enhanced tumour destruction with combined laser energy and chemotherapy.


Radiation sterilization of food.

Radiation sterilization of food.


Depletion of mouse spermatogonia following exposure to polonium-210.


Cytoplasmic localization of phytohaemagglutinin in peripheral white cells.


Production of yeast cell-wall lytic enzymes on a semi-defined medium by a Streptomyces.


Effect of temperature on intratesticular cryptococcal infection in rabbits.


Species of Absidia with ovoid sporangiospores. II.


Precipitating antibodies in chromomycosis.


Antigenic relationships between the fungus causing subcutaneous phycomycosis and saprophytic isolates of Basidiobolus meristosporus and B. ranarum.


The pattern of medical and veterinary mycological information.


Congenital cavities of the posterior fossa.


Hallervorden Spatz disease. Its pathogenesis and place among the axonal dystrophies.


Distribution of Alzheimer's neurofibrillary changes in the brain stem and hypothalamus of senile dementia.


Resection of vertebral transverse processes in idiopathic scoliosis.


Results of radical evacuation and arthrodesis in sacro-iliac tuberculosis.


Multiple-spike discharge evoking after-depolarizations in the slowly adapting stretch receptor neuron of the lobster. II. The slow after-depolarization.


The alveolar-arterial oxygen difference: its size and components in normal man.


Stimulation of urinary salt excretion following injections of hypertonic NaCl-solution into the 3rd brain ventricle.


Regional blood flow in the cerebral cortex, measured simultaneously by heat and inert gas clearance.


Cellular localization of monoamine oxidase in rat salivary glands.


Intestinal dipeptidases. IV. Studies on the release and subcellular distribution of intestinal dipeptidases of the mucosa cells of the pig.


Influence of ionic environment on acetylcholine release from the motor nerve terminals.


The loss of certain cellular components from human erythrocytes during hypotonic hemolysis in the presence of dextran.


Serotonine and temperature control.

Serotonine and temperature control.


Studies on the stimulating effects of adrenaline and noradrenaline on respiration in man.


Connections between adrenergic nerves and other tissue components in the eye.


Regulation of pigment cell colonization of PET mouse leg muscles.


Evidence for linkage between the transferrin locus (Tf) and the serum cholinesterase locus (E1) in man.


A study of cellular transport with the fluorescent amino acid, aminonaphthylalanine.


Guanosine diphosphate D-glucose glucohydrolase.


Isolation and amino acid composition of the tryptic peptides from the beta chain of C57BL-6 mouse hemoglobin.


Bioassay of seawater. II. Methods for the determination of concentrations of dissolved vitamin B1 in seawater.


Cellular mechanisms in experimental epilepsy. I. The effect of methionine sulfoximine on structure and function of cortical neurons.


DNA base composition of Cytophaga marinoflava n. sp. determined by buoyant density measurements in cesium chloride.


Inhibition of growth of Pseudomonas denitrificans by amino acids.


Influence of resistant and susceptible varieties of muskmelon on size of populations of the Fusarium wilt fungus and wilt in naturally infested soils.


The influence of amphetamine on the periodic feeding behavior of the albino rat.


Migration of bacteria on seedling plants.


Spike generation and propagation initiated in dendrites by transhippocampal polarization.


The effects of herbicides on the life-community of waters.


The mode of action of the antibiotic paromomycin on Staphylococcus aureus.


Uptake of organic and inorganic radioactive substances and multiplication of Mycobacterium leprae murium on alkaline galactomannan medium.


Production of green algae in deuterium oxide.


Experimental transmission of infectious dropsy of carp.


Regulation of proteinase formation in a species of Micrococcus.


Permeability of a micrococcal cell to maltose and some related sugars.


The inactivation and reactivation of a Proteus rettgeri phage in salt solutions.


Influence of clay minerals on microorganisms. 3. Effect of particle size, cation exchange capacity, and surface area on bacteria.


Electrophoretic blood protein research in healthy and infected carp.


Glutaconic acid, a product of the fermentation of glutamic acid by Peptococcus aerogenes.


The antimicrobial activities of carbonyl and thiocarbamoyl disulfides.


Redmouth disease of rainbow trout (Salmo gairdneri).


Experimental studies on fish tuberculosis.


Metabolism of D-tryptophan by a species of Flavobacterium.


The occurrence of microbial forms of unusual morphology in European and Asian soils.


Effect of splenectomy and sex in hamsters on adenovirus-12 oncogenesis.


Protozoa in the rhizosphere of Lolium perenne L.


The effect of isopropyl N-(3-chlorophenyl) carbamate on filamentous fungi and Saccharomyces cerevisiae.


Use of glucagon in insulin treatment and multiple dose technique of insulin administration.


Pneumohepatitis caused by Klebsiella aerogenes.


Fever associated with neoplastic disease.


The ill effects of cigarette smoking in dogs.


Pregnancy following bilateral ligation of hypogastric (internal iliac) arteries. Case report.


An analysis of 471 benign cystic lesions of the jaws.


Management of prostatectomy cases with the three way catheter (Foley-Stewart) and Redi-vac apparatus.


A review of 73 cases of congenital dislocation of the hip.


Partial nephrectomy for renal lithiasis. Experience with 208 cases.


Pregnancy in the rudimentary horn of a bicornuate uterus. A case report.


Mesonephroma (extra embryonal mesoblastoma) of the ovary.


Thoraco-abdominal injuries. A review of 134 cases.


An unusual variety of partial carpal agenesis.


Abdominal lymphangiomas.

Abdominal lymphangiomas.


Surgery in rhinosporidiosis. Experience with 293 cases.


A possible homeostatic mechanism in complement fixation: inhibition of the activity of fixed C'1 by the fixation of C'3a.


Complete inhibition of mouse leukaemia L1210 by 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide (NSC-82196).


Molecular weight of component 1 of the blood serum of diethylstilbestrol-treated cockerels.


Myocardial lesions in fatal eclampsia.

Myocardial lesions in fatal eclampsia.


The thymus and myasthenia gravis.

The thymus and myasthenia gravis.


The detection of diabetes in a general hospital out-patient department.


Integral heating device for the rose culture chamber.


Fungus culture on cellophane membrane for cytochemical tests.


Acidified phenol-phloxine for staining Negri bodies in paraffin sections.


Repair of hypospadias in the preschool child: a report of 150 cases.


Operation for correction of distal penile ventral curvature with or without hypospadias.


The renal papilla and the genesis of urinary calculi.


Distal tunnel ureteral reimplantation.

Distal tunnel ureteral reimplantation.


A new theory of the anatomy of the internal urinary spincter and the physiology of micturition.  IV. The urinary sphincteric mechanism.


Inappropriate secretion of antidiuretic hormone in urologic patients.


A new oral progestational steroid effective in treating prostatic cancer.


Masking properties of Bárány's noise box.


Gradients of CO2 tension in the brain.

Gradients of CO2 tension in the brain.


Effects of estrogen on the pituitary-gonadal axis of rats bearing lesions in the Periaqueductal Gray Matter.


Effect of prostaglandin E on plasma free fatty acids and blood glucose in the dog. Prostaglandin and related factors 51.


Pyramidal effect on alpha and gamma motoneurons.


Testing for doubly innervated fibers in the intrinsic laryngeal muscles of the dog.


Rubidium clearance during neurogenic redistribution of intestinal blood flow.


Effect of different doses of prostaglandin E on free fatty acids of plasma, blood glucose and heart rate in the nonanesthetized dog. Prostaglandin and related factors 53.


Concomitant adrenergic and parasympathetic fibres in the rat iris.


Pancreatic response to repeated secretin stimulation in dogs.


Metabolic effects of infused sodium L (+) lactate in man before and after triiodothyronine treatment.


Dextran-induced release of 5-hydroxytryptamine from rabbit platelets.


Electron microscopic observations on nerve terminals in the intrinsic muscles of the albino rat iris.


Effect of intravenous injection of chlormethiazole in spasticity, rigidity and tremor: preliminary communication.


Cytoplasmic microtubules in mammalian erythropoietic cells.


A variation in the plasma membrane of intestinal epithelial cells.


The influence of thyroid and testicular hormones on the epithelium of crypts of Lieberkühn in the rat's intestine.


The cranial attachment of the sphenomandibular (tympanomandibular) ligament.


Distribution and fine structure of globule leucocytes in respiratory and digestive tracts of the laboratory rat.


Relation between axial and appendicular skeletal calcium and body weight in the rat.


The heart weight and ventricular weights of normal adult albino rats.


Treating urinary schistosomiasis in the field: a clinical trial of Ambilhar, a treatment campaign for a school in an endemic area, and a pilot study for a mass-treatment programme.


New metabolites of 11-beta-hydroxy-delta-4-androstene-3,17-dione.


Pathway and stereochemistry of the formation of estriols in man.


The structure of neoxanthin and the trollein-like carotenoid from Euglena gracilis.


The biosynthesis of squalene, lanosterol, and cholesterol by minced human placenta.


Separation and properties of argininosuccinate and its two anhydrides and their detection in biological materials.


Photolytic and reductive cleavage of co-carboxymethylcobalamin.


Antibody affinity. II. Effect of immunization interval on antihapten antibody in the rabbit.


A nuclear magnetic resonance investigation of biotin. The biotin sulfonium ion.


Amino acid incorporation into protein by cell-free systems from rat skeletal muscle. V. Effects of pituitary growth hormone on activity of ribosomes and ribonucleic acid polymerase in hypophysectomized rats.


Cooperative effects in binding by bovine serum albumin. I. The binding of 1-anilino-8-naphthalenesulfonate. Fluorimetric titrations.


Tyrosine and tryptophan in cytochrome.

Tyrosine and tryptophan in cytochrome.


Cooperative effects in binding by bovine serum albumin.  II. The binding of 1-anilino-8-naphthalenesulfonate. Polarization of the ligand fluorescence and quenching of the protein fluorescence.


Inhibition of collagen intermolecular cross-linking by thiosemicarbazide.


Tyrosine ionization in human carbon monoxide and deoxyhemoglobins.


The reactivity toward N-bromosuccinimide of tryptophan in enzymes, zymogens, and inhibited enzymes.


Polymerization--depolymerization of tobacco mosaic virus protein. V. Osmotic pressure theory for hydrated proteins.


Chemical studies on hemocyanins. I. Amino acid composition.


Polymerization--depolymerization of tobacco mosaic virus protein. VI. Osmotic pressure studies of early stages of polymerization.


The alteration in the reactivity of the tyrosine and tryptophan groups of trypsin upon combination with protein inhibitors.


Inter- and intramolecular interactions of alpha-lactlabumin. VI. Optical rotation dispersion properties.


Study of the polarity of the active site of chymotrypsin.


Hydrolysis of neutral substrates by acetylcholinesterase.


Chemical structure and function of the active center of acetylcholinesterase.


Organic modifications of metallocarboxypeptidases.


The behavior of horseradish peroxidase at high hydrogen peroxide concentrations.


Some catalytic properties of human liver alcohol dehydrogenase.


The protonation of poly-gamma-benzyl-L-glutamate in mixed solvents containing dichloroacetic acid.


The preparation and tryptic hydrolysis of S-aminoethylated tobacco mosaic virus protein.


Structural studies of ribonuclease. 23. Pairing of the tyrosyl and carboxyl groups.


Nucleotides. V. Purine ribonucleoside 2',3'-cyclic carbonates. Preparation and use for the synthesis of 5'-monosubstituted nucleosides.


Aminoacyl nucleosides. 3. A novel rearrangement: conversion of N-6-(alpha-aminoacyl) adenines into N-(6-purinyl) amino acids.


Purification and properties of inactive liver phosphorylase.


On the role of pyridoxal 5'-phosphate in phosphorylase. II. Resolution of rabbit muscle phosphorylase b.


A mixed photoproduct of uracil and cysteine (5-S-cysteine-6-hydrouracil). A possible model for the in vivo cross-linking of deoxyribonucleic acid and protein by ultraviolet light.


On the role of pyridoxal 5'-phosphate in phosphorylase. 3. Physicochemical properties and reconstitution of apophosphorylase b.


Phospholipase activity in rat-liver microsomes studied by the use of endogenous substrates.


Pancreatic enzymes of the spiny Pacific dogfish. I. Cationic chymotrypsinogen and chymotrypsin.


States of amino acid residues in proteins. X. Tyrosine residues in oxytocin and glucagon.


State vector description of the proliferation of mammalian cells in tissue culture. I. Exponential growth. Proliferation of mammalian cells, even under conditions of unlimited growth, presents a complex problem because of the interaction of deterministic and stochastic processes. Division of the cell cycle into a finite number of parts establishes a multidimensional vector space. In this space an arbitrary culture can be represented by a vector called the state vector. The culture's subsequent growth is represented mathematically as a series of transformations of the state vector. The operators effecting these transformations are presented in matrix form and their relationship to the distribution of cell generation times is described. As an application of the model, the growth of an initially synchronized culture is considered and an unambiguous measure of the degree of synchrony is proposed. Results of a computer simulation of such a culture show the behavior with time of the degree of synchrony, the total cell number, and the mitotic index. In particular the importance of the magnitude of the coefficient of variation of the generation time distribution is illustrated.


Treatment of low angle x-ray data from planar and concentric multilayered structures. Low angle X-ray diffraction can be recorded from planar and concentric multilayered (biological) structures. In order to proceed with the X-ray analysis the relation between the observed intensities and the Fourier transform of the unit cell is required. This relation is derived for planar structures such as retinal rods, mitochondria, and collagen; and also for nerve myelin.


Dreams and the creative process.

Dreams and the creative process.


Cell cycle kinetics and radiation-induced chromosomal aberrations studied with C14 and H3 labels. Chinese hamster cells in vitro were double labeled with C(14)TdR and H(3)TdR. At the time of irradiation with Co(60) gamma rays (600 rad), the cells in the G(2) phase were labeled only with C(14), whereas cells in the late and middle S phases were labeled with both C(14) and H(3). The cells in early S phase were labeled only with H(3) and the G(1) cells were unlabeled. Samples were fixed at various time intervals following irradiation and the metaphases were analyzed for chromosomal damage. The phase in which the cell was located at the time of irradiation was determined by counting grains in the first and second layers of autoradiographic film. In both control and irradiated cells some G(1) cells divided prior to some of the cells which were in the S phase denoting mixing of the populations. The G(2) phase sustained three times more chromosomal damage than the S phase. Little difference in chromosomal damage was found between the G(1) and S phases or among the different parts of the S phase. Cells in G(2) sustained a mitotic delay of 4 hr, while the other phases sustained a delay of 2 to 3 hr. Chromatid and chromosome (dicentrics) exchanges were induced in G(1) cells but only chromatid exchanges were induced in S and G(2) cells; this is consistent with the hypothesis that the chromosome consists of two subunits which separate either slightly before or immediately as the cell enters the S phase.


Mental illness and early profound deafness.


Melancholy in medicine and literature: some historical considerations.


Psychotherapy and confrontation technique theory.


Probability and schizophrenia.

Probability and schizophrenia.


Psychodynamic aspects of drug experiences.


A multiple-choice version of the TAT as a measure of aggression in psychiatric patients.


Micro determination of calcium in serum.


Synthesis of plasma proteins by the perfused rat liver. Effects of protein free diet, 3'-MDAB and dimethylnitrosamine.


Safety considerations in the use of nuclear devices in space.


Deposition of some fission products of stratospheric origin on tropospheric aerosols.


Distribution of radioactivity on a polydisperse aerosol by the diffusion method.


Radionuclide fractionation in debris from a land surface burst.


Nuclear track registration in dosimeter glasses for neutron dosimetry in mixed radiation fields.


A tissue-equivalent ionization chamber for inphantom dosimetry: comparison of measured values with calculated values.


The meanings of "first collision dose".

The meanings of "first collision dose".


Biology spectrometer and analyzer.

Biology spectrometer and analyzer.


Predicting the total projected intake of radioiodine from milk by man. I. The situation where no counter measures are taken.


Predicting the total projected intake of radioiodine from milk by man. II. The situation where counter measures are employed.


Creatinine in urine as an index of urinary excretion rate.


Thermoluminescent dosimeters for environmental monitoring.


Modification of the Toshiba FGD-3B glass dosimeter reader to improve accuracy and reproducibility.


Neutron dose conversion factors for radioactive neutron sources.


Neutron dose conversion factors for Am Be and Am B sources.


In situ measurement of the efficiency of absolute filters.


Calibration of the ORNL model Q-2240, continuous air monitor.


Debris from the Chinese atomic test of May 1965 intercepted over the Northwestern United States.


Beta doses in contaminated areas.

Beta doses in contaminated areas.


Half-life of iodine-125.

Half-life of iodine-125.


Buying film badge dosimetry services--some notes for purchasing agents.


Use of C14 in studying the reaction of oxalic acid re-formation during gamma radiolysis of aqueous oxalate solutions.


Drug Abuse Control Amendments of 1965.

Drug Abuse Control Amendments of 1965.


Concentrating compounds by continuous horizontal thin-layer chromatography.


The ultrastructural characterization of macroglial cell types.


The aerobic pseudomonads: a taxonomic study.


Some strains in search of a genus--Corynebacterium, Mycobacterium, Nocardia or what?


Water relations of Salmonella oranienburg; stimulation of respiration by amino acids.


Anatomical features of Vibrio fetus: Electron microscopic survey.


The preparation and characterization of cell walls and the preparation of flagella of Vibrio fetus.


The kinetics of cholinesterases measured fluorometrically.


Subcellular localization of rat brain esterases.


Histochemical identification of noradrenaline in fluorescence microscopy by borohydride-periodic acid sequence.


Cytological localization of noradrenaline, monoamine oxidase and acetylcholinesterase in salivary glands of dog.


Quantitative distribution of lactic dehydrogenase in the regenerating liver lobule of the rat.


Spatial resolution by the human visual system. The effect of mean retinal illuminance.


Excitation of waveguide modes in retinal receptors.


Recognition of signal colors by a different set of color names.


Positive afterimage following brief high-intensity flashes.


Automatic photoelectric keratometer.

Automatic photoelectric keratometer.


Characteristics of the visual system. Psychophysical measurements of the response to spatial sine-wave stimuli in the photopic region.


Locus of perceived equidistance as a function of viewing distance.


Retinal microspectrophotometry.

Retinal microspectrophotometry.


Interaction of flicker and apparent movement.


Myocardial contractility in ovariectomized rats.


Action of anti-inflammatory agents upon blood and histopathologic changes induced by periarthritis in rats.


Effect of orally administered tryptophan on tryptophan pyrrolase activity in ovine and bovine.


The effects of harmine and tranylcypromine on the pressor responses to biogenic amines in the reserpine-pretreated dog.


The effects of disulfiram on the repletion of brain catecholamine stores.


A further test of Hick's law with unequally like alternatives.


Insulin: inducer of glucose 6-phosphate dehydrogenase.


Responses of some endocrine organs of female hamsters to pinealectomy and light.


Relationship between time estimation and retentive personality traits.


Interocular transfer of adaptation to prismatic distortion.


Further studies on the effect of testosterone on liver healing after partial hepatectomy in male rats.


Experimental studies on the intestinal flow using 51-Cr as indicator.


Pre-scalene lymph node biopsy in the evaluation of gastric carcinoma.


Effects of calcium infusion on gastric secretion in Heidenhain pouch dogs.


Controlled radiological evaluation of an intestinal pacemaker (Persistart).


Gastric secretion before and after graded partial gastrectomy for duodenal ulcer.


Gastric juice sulphomucoprotein and vitamin B12 binding.


Levels of uridine diphosphate glucose dehydrogenase and UDPG in the gastrointestinal mucous membrane.


Gastrointestinal tract in hyperthyroidism before and after treatment.


Ductal factors in the pathogenesis of acute pancreatitis in the rat.


Single gastric biopsy in subjects with low acid secretion after maximal histamine stimulation.


Studies on antitumor activity of phenazine derivatives against S 180 and C 63 in mice. II.


Effects of 60Co gamma-ray irradiation on glycogen metabolism and DNA synthesis of Yoshida sarcoma.


Primary drug resistance.

Primary drug resistance.


Pulmonary diffusing capacity of various kinds of lung and heart diseases.


The pulmonary function tests and prognosis of chronic obstructive lung diseases.


Simultaneous measurements of pulmonary capillary blood flow and pulmonary capillary volume by the single breath method.


Intensity distribution of heart sounds and murmurs on the anterior chest surface.


Tuberculosis among immigrants to England and Wales: a national survey in 1965.


A two-year follow-up of patients with quiescent pulmonary tuberculosis following a year of chemotherapy with an intermittent (twice-weekly) regimen of isoniazid plus streptomycin or a daily regimen of isoniazid plus PAS.


Absorption and excretion studies with thiocarlide (4'4-diisoamyloxythiocarbanilide) in man.


Thiocarlide (4'4-diisoamyloxythiocarbanilide) blood levels in patients suffering from tuberculosis.


Capreomycin.

Capreomycin.


The Veterinary Surgeons' Bill.

The Veterinary Surgeons' Bill.


Effect of an injection of iron-dextran complex on blood constituents and bodyweight of young kids.


Green Europe.

Green Europe.


Studies of the effectiveness of "free access" feeding of a magnesia-molasses mixture for the prevention of hypomagnesaemia in dairy cows at pasture.


The British veterinary profession and the European Economic Community. II.


Antibiotics: medical and veterinary control.


Identification of vehicle tire rubber in roadway dust.


Spectrographic determination of microgram quantities of tellurium in biologic materials.


Limits of detection of beryllium in tissues by microemission spectrography.


Reproducibility of single oral dose toxicity testing.


Distribution of cholinesterase within the sinus node and AV node of the human heart.


Initiation of vagal control of heart rate in the embryonic chick.


The development and structure of the choledocho-duodenal junction in Balaenopteran whales.


The fine structure of iridial constrictor pupillae muscle of Alligator mississippiensis.


Bacterial air pollution from activated sludge units.


Practical designs for noise barriers based on lead.


The effect of pregnancy on the submandibular glands of mice.


Indices of heart rate as substitutes for respiratory calorimetry.


An electromyographic analysis of certain movements and exercises. I. Some deep muscles of the back.


Fine structure of the seminiferous tubule of the Swiss mouse. The spermatid.


Deposition and fate of inhaled iron-59 oxide in rats.


Hygienic guide series. Ethyl acrylate (Ethyl propenoate).


Cyclic changes in the squamo-columnar junction of the mouse cervix uteri.


Comparative anatomical and neurohistological observations on the tongue of the porcupine (Histrix cristata).


Status of committee work on air pollution control equipment.


Discussion of the interpretation of threshold limit values.


The standard man in relation to internal radiation dose concepts.


The evaluation of efficiency and variability of sampling for atmospheric nitrogen dioxide.


Hygienic guide series. Ethylene glycol dinitrate (Nitroglycol, dinitroglycol, EGDN, EGN, ethylene nitrate).


Amoeba acid phosphatases. II. Distribution in cell fractions from Chaos chaos L.


The relationship of RNA synthesis to temperature as an inducer of synchronous division.


Differential developmental patterns and their adaptive value in various species of the genus Citellus.


Dietary fat, age and hepatic alkaline phosphatase activity in the rat.


Growth and development of the little pocket mouse, perognathus longimembris.


A study of the effects of thyroid hormones on growth and development.


Body weight and surface area of chickens (Gallus domesticus).


Rate of growth of solid tumours as a problem of diffusion.


A correlated growth response of spleen and liver during the graft-versus-host reaction in the chick embryo.


Dynamics of embryonic growth.

Dynamics of embryonic growth.


Lung tissue resistance in normal and asthmatic subjects.


Cardiopulmonary function and exercise tolerance in supine and sitting position in patients with pectus excavatum.


Metabolic criteria for primary hyperparathyroidism.


Oxygen measurements in blood and tissues and their significance. General discussion.


The measurement of oxygen tension in tissues.


Oxygen transfer by the lung.

Oxygen transfer by the lung.


The significance of oxygen tension measurements in tissues.


Arterial oxygen tensions in surgical patients.


Alveolar-arterial PO2 differences in anaesthesia.


The development of ideas on oxygen transport by the blood.


Interrelationships between blood oxygen tensions and cerebral blood flow.


Hypoxia in man.

Hypoxia in man.


Methods of measuring oxygen content of blood.


Hyperbaric oxygen and the significance of increased cerebral oxygen and carbon dioxide tensions.


The theory and construction of oximeters.


Anesthetic assessment of the neurosurgical patient.


General principles of anesthesia for intracranial surgery.


Hyperventilation technique.

Hyperventilation technique.


Physiological aspects of hyperventilation.


Posture.

Posture.


Control of brain volume and intracranial pressure.


Monitoring and general management of patients undergoing craniotomy.


Head injuries.

Head injuries.


Postoperative care.

Postoperative care.


Pain problems.

Pain problems.


Contraction kinetics of striated muscle fibres following quick changes in load. 1. The contraction kinetics of single striated muscle fibres and small fibre bundles from the frog and the toad were measured when the load was changed from P(0) to L < P(0). Simultaneous recordings were made of displacement at one end and force at the other end of the preparation.2. After the load was changed, the contractile force generally reached a steady value before the contraction velocity became steady. The amount of time required for isotonic contraction to become steady depended on the change in fractional load and on the temperature; it did not depend on sarcomere length in the range 2.2-3.0 mu or on the number of fibres in the preparation. The characteristics of the non-steady state are described in terms of the displacement deviation (the difference between the actual displacement at a given time and the back extrapolation of the steady phase of the displacement record) and the null times (the times at which the displacement deviation became zero, measured relative to the time at which the contractile force first reached the value of the load).3. The time average of the transient velocity was approximately equal to the final steady velocity.4. The product of the null time following a given relative force step and V(max), the steady velocity of unloaded contraction, was found to be independent of temperature. This is taken as evidence that the isotonic velocity transients originate in the contractile mechanism.5. The non-steady state following step changes in load is identified with the motion of cyclic contraction mechanisms. The motion of the specific model formulated by A. F. Huxley (1957) was compared with that of frog muscle fibres and, although the transients in the two systems differ in detail, the characteristic dimensions are of the same order.


The effects of cyclopropane, halothane and ether on central baroreceptor pathways. 1. The reductions in arterial pressure and preganglionic sympathetic activity evoked by aortic nerve stimulation in the rabbit were studied before and during administration of constant inspired concentrations of the inhalation anaesthetics cyclopropane, halothane, and ether. The background anaesthetic was pentobarbitone, gallamine triethiodide was given, and pulmonary ventilation was with 100% oxygen.2. During light pentobarbitone anaesthesia, aortic nerve stimulation usually induced similar reductions in arterial pressure and preganglionic discharge, expressed as the maximum percentage reduction from prestimulation levels. There were two components in the sympathetic responses, attributable to A and C fibre excitation in the aortic nerve, which was also shown to contain a third fibre group with properties similar to those of B fibres.3. The arterial pressure, heart rate, and preganglionic sympathetic responses to aortic nerve stimulation were rapidly and profoundly inhibited by 50% cyclopropane, which also produced arterial hypertension.4. Halothane (3%) significantly inhibited the depressor responses, but even in the presence of severe hypotension the arterial pressure could usually be further reduced by aortic nerve stimulation. The inhibitory effects of 2% halothane were slow in onset and not pronounced. In the concentrations used, these actions of halothane were significantly less than those of cyclopropane.5. The inhibitory effects of ether on the depressor responses were roughly intermediate between those of cyclopropane and halothane; complete suppression of the responses occurred with high ether concentrations, which were also liable to cause circulatory collapse.6. It is concluded that the three anaesthetics significantly inhibit impulse transmission through central baroreceptor pathways; the implications of the findings are discussed in relation to the different circulatory actions of these anaesthetics.


The effect of an intravenous infusion of hypertonic saline on renal mechanisms and on electrolyte changes in sheep. 1. The ability of the sheep to tolerate excess sodium chloride has been investigated by subjecting sheep to an intravenous infusion of a 10% solution of sodium chloride.2. Inulin and diodrast clearances failed to show any consistent changes in glomerular filtration rate but the effective renal plasma flow was slightly more. Plasma levels of sodium and chloride increased by 20-25% and potassium decreased by 30%. Urinary levels for sodium and chloride showed a corresponding increase and potassium excretion was reduced.3. The rates of re-absorption of sodium and chloride from the renal tubules were found to be proportional to their rates of filtration at the glomerulus, but this ratio was reduced after the hypertonic saline infusion. No such correlation could be established for potassium.4. Osmolar clearances indicated that continued re-absorption of osmotically free water from the kidney tubular fluid occurred during and after the hypertonic saline. Excretion of urine, hyperosmotic to plasma, was thus maintained and water conservation supported.5. Possible renal mechanisms associated with these effects are discussed.


Onset of contractility in cardiac muscle. 1. A technique is described whereby (i) quick stretches and releases of controlled velocity, amplitude and time of onset can be applied to muscle. (ii) Releases from isometric to isotonic contraction can be performed at controlled delays relative to the stimulus, and displayed on a delayed expanded oscilloscope sweep. An isotonic lever system with an equivalent mass of 12.8 mg is described.2. Quick stretch of rabbit or cat papillary muscle after excitation does not result in a level of tension equal to or greater than normal peak isometric tension appropriate to the stretched length. Stretches applied during the first half of the rising phase of tension development give responses nearly identical to the same stretches applied before the stimulus (indicating that Starling's Law of the heart holds until this time). Stretches applied in the later phase of tension development or during relaxation result in diminished peak isometric tensions or accelerated relaxation.3. The rate of tension development following quick releases of isometrically contracting muscle to zero tension is not maximal until the releases are made 150-200 msec after excitation.4. Shortening velocity with light afterloads is not initially maximal nor constant for an appreciable period of time. The shortening velocity with heavy afterloads reaches its maximum more rapidly when the load is not lifted within the first 200 msec of a contraction which, if maintained isometric, would have required 400-500 msec to reach peak tension. With these heavier loads, a period of 100-200 msec of constant shortening velocity may occur.5. Freeloaded isotonic contractions show an inflexion in their shortening curves occurring 150-200 msec after excitation.6. Maximum rate of isotonic shortening following releases from isometric to isotonic contraction with a given load is not maximal until the releases occur about 200 msec after the stimulus.7. It is concluded that contractility in cardiac muscle is relatively slow in its onset with maximum capacity to shorten occurring about midway through the rising phase of isometric tension development.


The importance of peripheral changes in determining the sensitivity of striated muscle to depolarizing drugs. 1. The sensitivity of the flexor digitorum longus and soleus muscles to depolarizing drugs was tested after cross-union of their respective motor nerves.2. The alien innervation did not affect the sensitivity of either the flexor digitorum longus (FDL) or soleus muscles, which retained their normal characteristic responses to decamethonium and suxamethonium. The time course of muscle contractions was, however, altered by the cross-union operation.3. A considerable increase in sensitivity to depolarizing drugs was shown after de-afferentation and after tenotomy of the soleus muscles. Both these conditions are associated with muscle atrophy.4. It is suggested that hypersensitivity to depolarizing drugs can be expected in any situation where the muscle is undergoing atrophy.


Chemoreceptor reflexes in the new-born infant: effects of varying degrees of hypoxia on heart rate and ventilation in a warm environment. 1. We studied the effects of varying degrees of hypoxia for 3 min periods on the heart rate and respiration of thirty-three healthy full-term infants in a warm environment.2. During the first 5 days of life a decrease in alveolar oxygen tension (P(A, CO2)) below 80 mm Hg induced hyperventilation, a decreased alveolar carbon dioxide tension (P(A, CO2)), and tachycardia during the first minute of hypoxia. During the second and third minute, while the decreased P(A, CO2) and tachycardia persisted, ventilation fell. There was a further fall in ventilation when the baby breathed 21% O(2) again. This response was also observed when the inspired gas was heated to 35 degrees C.3. During the first 5 days of life a decrease in P(A, CO2) between 81 and 100 mm Hg did not affect ventilation or P(A, CO2) during the first minute of hypoxia, but still induced a tachycardia and a fall in minute volume during the second and third minute.4. When the P(A, CO2) was elevated and maintained constant during hypoxia, ventilation increased during the first minute and fell during the second and third minutes, suggesting that hypocapnia did not explain the transient ventilatory response to hypoxia.5. After the first week of life a greater and maintained increase in ventilation was seen during hypoxia. This response was potentiated by the addition of CO(2).6. The possibility that changes in the pulmonary circulation, associated with a functionally patent ductus arteriosus, may explain these differences, is discussed.


A study of parotid salivation in the horse. 1. Saliva flowed from the horse's parotid duct only during mastication.2. The surface-active local anaesthetic administered by mouth inhibited salivary secretion.3. Salivary secretion was stimulated by pilocarpine and inhibited by atropine.4. The volume and composition of saliva secreted in 24 hr from one parotid duct was determined.5. The concentration of sodium, potassium, calcium, chloride and bicarbonate depended upon the rate of flow. The highest concentrations of these electrolytes were observed during periods of high flow rates.6. Horse parotid saliva contained a high concentration of calcium.7. In the absence of a dietary supplement of sodium bicarbonate, the sodium concentration of the saliva fell after about 21 days. There was an associated increase in the potassium concentration. The addition of a sodium supplement restored the sodium concentration of the saliva within 24 hr.


Amino acid transport in the goldfish intestine. 1. The serosal transfer of the following eight amino acids: threonine, alanine, serine, histidine, valine, methionine, phenylalanine and leucine, was measured using everted sacs of anterior intestine taken from goldfish acclimatized to 8 degrees C and incubated at 25 degrees C.2. All eight amino acids were actively transported and the serosal transfer correlated with the steady potential (P < 0.001) and with the amino acid-evoked potential (P < 0.05) measured on the same preparations.3. The goldfish rectum actively transported alanine and the steady potential was raised when alanine bathed the mucosa of the everted preparation.4. L-aspartic acid was partly transaminated to alanine by the goldfish anterior intestine; the rectum transaminated alanine to an unidentified amino acid which might have been serine, asparagine or glutamine or some mixture of these three.5. It is suggested that L-amino acids increase the ease by which sodium enters the mucosal cell but that it is the rate at which this sodium is transported across the basal membrane which determines the net serosal transfer of amino acids.


The subcellular localization of kallikrein, amylase and acetylcholine in the submaxillary gland of the guinea-pig. 1. The subcellular distribution pattern of kallikrein was compared with that of amylase and acetylcholine in submaxillary gland homogenates of the guinea-pig.2. Kallikrein was located in particles which sedimented in the nuclear (46%) and mitochondrial (17%) fractions. These particles were probably similar if not identical to zymogen granules.3. The above observations would support a digestive role for salivary kallikrein.


Analysis of actions of 5-hydroxytryptamine in pregnancy. 1. When 5-hydroxytryptamine creatinine sulphate is injected subcutaneously in a dose of 2 mg into mice during the second half of pregnancy, the foetuses die within 1 hr. The mode of action of 5-hydroxytryptamine (5-HT) in producing this effect has been studied.2. It has been demonstrated that this is not a direct toxic effect of 5-HT. Very little passes through the placenta into the foetus, and after the injection of much larger amounts directly into the foetus no lethal effect was observed.3. It was shown that 5-HT had little effect on uterine motility in vivo, and that the much larger contractions produced by oxytocin did not produce any effect on the foetus.4. No constriction of the umbilical vessels was produced by 5-HT injected into the mother, nor did the local application of 5-HT to the cord produce any effect.5. The administration of 5-HT to the mother markedly reduced the passage of (22)Na from the maternal circulation into the placenta and foetus. This was accompanied by a reduction in the blood supply to the placenta from a normal value of 87 mul./min/g to 4 mug/min/g.6. It is suggested that the effect of 5-HT in producing foetal death is a consequence of the reduction in the transfer function of the placenta.


The role of a central temperature receptor in shivering in man. 1. Five subjects with spinal cord transections and one subject unconscious from a head injury have been studied when the deep tissue temperature (;central' temperature) was artificially lowered but normally innervated skin was kept warm, usually 34-36 degrees C.2. Shivering and/or increased metabolism was evoked when the central temperature was 34.9-37 degrees C.3. These observations are compatible with the view that there is a central receptor which can cause shivering when stimulated by a fall in central temperature.


The control of the circulation in skeletal muscle during arterial hypoxia in the rabbit. 1. The effects of arterial hypoxia on muscle blood flow were examined in normal unanaesthetized rabbits in relation to simultaneously determined changes in cardiac output, arterial pressure and heart rate. Muscle blood flow was estimated from the difference between total limb flow (local thermodilution) and the estimated skin flow (using a calibrated heat conductivity method). The role of the arterial chemoreceptors and baro-receptors in the control of muscle blood flow was examined and the nature of the sympathetic efferent discharge analysed.2. In mild hypoxia (P(O2) > 35 mm Hg) in the rabbit, muscle blood flow did not change, although cardiac output increased. During moderate hypoxia (P(O2) 30-35 mm Hg) there was initial vasoconstriction in muscle, followed by a return to control values paralleling the changes in cardiac output. In severe arterial hypoxia (P(O2) < 30 mm Hg) the initial vasoconstriction was less marked, and during the ;steady state' there was a large vasodilatation and increase in muscle blood flow, at a time when the cardiac output was not elevated.3. The early vasoconstriction in arterial hypoxia is mediated mainly through sympathetic vasoconstrictor nerves as a result of strong arterial chemoreceptor stimulation.4. Increased secretion of adrenaline is an important factor in restoring muscle blood flow to control values during moderate arterial hypoxia, and in elevating the muscle blood flow above these values in severe hypoxia. The peripheral dilator (beta-) effects of adrenaline oppose the peripheral constrictor (alpha-) effects resulting from increased activation of sympathetic constrictor nerves during arterial hypoxia.


The relation of test anxiety and defensiveness to test and school performance over the elementary-school years: a further longitudinal study.


Some contributions of the psychoanalytic concept of development to personality research.


Discussion: personality and social psychology.


The concept of development: relevant and irrelevant issues.


Discussion: the delimitation of cognitive development.


Measurement of the minimum cosmic background radiation at 20.7 cm wave-length.


Biosynthesis of the phytosterol side chain.


Ascorbic acid and the lung.

Ascorbic acid and the lung.


Rate of dissolution of griseofulvin and hexoestrol in bile salt solutions.


Glycerol as a substrate for brain metabolism.


Optical isomers of propranolol.

Optical isomers of propranolol.


Variable size of the septal nuclei in man.


Production of antibody against "Australia antigen" in rabbits.


Tea as a source of urinary ethylamine.

Tea as a source of urinary ethylamine.


Effect of quinidine and related compounds on uptake and release of serotonin by blood platelets.


Metabolism of alpha-carotene.

Metabolism of alpha-carotene.


"Endogenous" alcohol in body fluids.

"Endogenous" alcohol in body fluids.


Effect of reserpine on the reactivity of atrial and ventricular pacemakers to quinidine.


Transplantation and function of a histo-incompatible tumour in thymectomized rats.


Effects of 3,4-dimethoxyphenylethylamine in man.


Effect of pH on human complement activity.


Adenovirus 12 virion-free "T" antigen from infected cells inhibited with cytosine arabinoside.


Significance of a single-hit event in the initiation of antibody response.


Thalamic inhibitory interneurone.

Thalamic inhibitory interneurone.


A simple catheter for intermittent intravenous anaesthesia in animal surgery.


Potential and resistance measurements of rat liver cells in situ.


Distribution of colloidal particles in extracellular space and synaptic cleft substance of mammalian cerebral cortex.


Induction of lung tumours by the action of radiation and urethane.


Degradation of ribonucleic acid in dilute solution by ionizing radiation.


Metabolic dissociation of the parent and daughter radionuclide pair, barium-140 and lanthanum-140.


Effects of fast neutrons on eye colour mutations in Dahlbominus.


Phenotypic mixing between group A arboviruses.


A simple method for measuring the motor activity of fleas (Xenopsylla cheopis Roth.).


Problems of differential indications in psychopharmacotherapy.


Treatment of polycythaemia vera with myelobromol.


Peripheral vasodilator action of mydocalm.


Treatment of outpatients in the psychiatric practice with nuredal and its combinations.


Use of depersolone in emergency medicine.


Electrophoretic patterns of the venoms of six species of Israeli scorpions.


Proteolytic enzyme activities of snake venoms.


On the response of rat liver mitochondria to treatment with bee venom.


Electrophoretic patterns of venoms from species of Crotalidae and Elapidae snakes.


Cross neutralization of the coagulant activity of some snake venoms by antivenins.


Capillary permeability in experimental rapid freezing with rapid and slow rewarming.


Proteins in human thoracic duct lymph. Studies on the distribution of some proteins between lymph and blood.


The influence of posture upon the pressure in the veins of the normal human leg at rest and during rhythmic muscular exercise.


The treatment of soft tissue sarcomas--a plea for a more urgent and aggressive approach.


The mechanism of vasopressin hemostasis in bleeding esophageal varices. An angiographic study in the dog.


Gastroscopy. Its value in the diagnosis of ulcer or tumour of the stomach.


Glucose tolerance curves after partial gastrectomy. Relationship to postgastrectomy symptoms.


A fatal case of Torulopsis glabrata fungaemia.


Resection of a stricture in an artificial antethoracic oesophagus.


Inguinal prolapse of retroperitoneal fat ("fatty hernia"). Report of a case also involving the ureter.


Rationalization and optimalization of haemodialysis procedure.


Mean body temperature and the control of thermal sweating.


The electrical measurement of chloride fluxes in Nitella.


Efficacy of sulfaethoxypyridazine against fowl cholera in artificially infected chickens and turkeys, and its safety in laying chickens and broilers.


Effect of culture medium on antigenic structure of mycoplasma.


Influence of poultry house dust, ammonia, and carbon dioxide on the resistance of chickens to Newcastle disease virus.


Airacculitis in turkeys. II. Use of tylosin in the control of the egg transmission of Mycoplasma gallisepticum in turkeys.


Paper electrophoretic studies of the serum proteins of chicks during experimental spirochetosis.


The influence of inhalation of carbon dioxide on chickens, including resistance to infection with Newcastle disease virus.


Serologic tests for Arizona group infections.


Uterine motility at the onset of labour.


Variations in the morphological substrate of the smooth muscle cells of the pregnant and non-pregnant human uterus.


Cervical dilatation with respect to the resistance of the lower parts of the uterus during labour.


Tocographic studies of the effects of transbuccal oxytocin.


Tocographic observations in a case of therapeutic abortion.


Electrolyte changes following transabdominal intraovular injection of hypertonic saline. A preliminary report.


Muscle content of the uterus under normal and pathological conditions.


Attempts to suppress contractions with Duvadilan (isoxsuprine hydrochloride) in women in labour.


The efficiency of contractions and the significance of spasmolysis with particular reference to the influence on pain in labour.


Problems of the extracellular space and ion distribution in human myometrium.


The effect of progesterone on human myometrial adenosinetriphosphatase activity and membrane potential.


Experiments on the inhibition of uterine motility in premature labour.


Autonomic nervous system and mental pathology.


Partial purification of a 2-oxo-glutarate:glyoxylate carboligase from rat liver mitochondria.


Non-randomness in base sequences of DNAs.


Specificity in deacylation of acyl-alpha-chymotrypsins.


A novel differential titration to determine pK values of phenolic groups in tyrosine and related aminophenols.


A membrane-filter technique for the detection of complementary DNA.


Constitutive and inducible isozymes of alpha-ketoglutaric semialdehyde dehydrogenase in Pseudomonas.


Acriflavine inhibition of dark repair and late generation death.


Activation of Mg++ accumulation in isolated heart mitochondria by Zn++ and by p-chloromercuribenzene sulfonate.


Non-stoichiometric sulfhydryl loss with vitamin K5.


Operation of orotic acid pathway as the major source of pyrimidines in the hematopoietic mouse spleen.


Synthesis of Co-methyl cobalamin by cell-free extracts of Clostridium thermoaceticum.


Metabolic differences between mitochondria isolated from various tissues.


A convenient method for the preparation of S-peptide from bovine pancreatic ribonuclease.


Subunit form of calf thymus DNA.

Subunit form of calf thymus DNA.


On the mechanism of hydrolysis of N-acylamino acid nitrophenyl esters.


Identification of sialic acids in human and bovine fibrinogen.


Relationship between iodination and conformation of thyroglobulin.


The demethylation of m-methyl orange and methyl orange in vivo and in vitro.


Subcellular distribution of norepinephrine in the normal and surgically denervated cat heart.


Importance of acetaldehyde in the action of ethanol on brain norepinephrine and 5-hydroxytryptamine.


Interrelationship of chemical structure and antiacetylcholinesterase activity of disubstituted quinazolones.


Is N-hydroxyurethane an active metabolite of urethane in the rat?


Activation of some organophosphorus insecticides by liver microsomes from phenobarbital-treated mice.


In vitro decomposition rate of degranol in sensitive and resistant NK/lymphoma ascites tumours.


Mode of action of prostaglandins on the human non-pregnant myometrium.


The relationship between chemical structure and protective effect of dithiocarbamate derivatives against experimental hepatic injury induced by carbon tetrachloride administration in rats.


Effect of cyanide upon oxidative phosphorylation of lung mitochondria of guinea pig.


Partial and total pancreatectomy for periampullary carcinoma. Total pancreatectomy for periampullary carcinoma should be reserved for resectable primary carcinoma in the pancreas. The postoperative complications are reduced, and the resultant diabetes is not difficult to manage. There were no postoperative deaths in series of 12 cases of total and partial pancreatectomy. This study proposes a more aggressive approach to malignant lesions in this area.


Community mental health.

Community mental health. The distinctive feature of a community mental health program is the comprehensive responsibility assumed for the mental health as well as the psychiatric needs of a particular area. Not only must programs provide psychiatric services but, in addition, they are concerned with assessing the community's psychiatric and mental health status; with preventive services; with mental health education; with contributions directed toward the solution of certain social problems; as well as with a variety of other indirect services, including, importantly, mental health consultation. This form of consultation can support and help the large number of community care-takers whose contribution is vital to the promotion of community mental health.


Small bowel obstruction due to intramural hematoma during anticoagulant therapy, a non-surgical condition. Intramural hematoma of the small bowel should be suspected in any patient with signs or symptoms of small bowel obstruction who is having anticoagulant drug therapy, especially if it is longterm therapy and if the prothrombin time is excessively prolonged. A barium study is indicated and if the roentgen pattern is characteristic, conservative treatment is indicated. Unless there is an associated abdominal lesion requiring operation, most patients will improve in four to six days. Those not improving usually have other complicating conditions.


Goodpasture's syndrome. Report of a case with an unusual clinical course.


Tuberculous tenosynovitis in a patient with hyperuricemia.


Acute intermittent porphyria.

Acute intermittent porphyria. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California Medical Center, San Francisco. Taken from transcriptions, they are prepared by Drs. Martin J. Cline and Hibbard E. Williams, Assistant Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.


Plusses and minuses: the California Medical Assistance program.


Hemophilus aphrophilus endocarditis successfully treated with ampicillin and streptomycin.


Tape recordings in medical education. The pioneering role played by the California Medical Association's Audio-Digest Foundation.


Approach to the objective diagnosis of hoarseness.


Evaluation of anti-leprosy activities or programmes.


Mutual dependence of epidemiological variables in the causation of disease (a view point).


A study of general practice in and around Calcutta.


Study of menstrual pattern of college girls--Poona.


A review of maternal mortality at the maternity hospital, Pondicherry.


Detection and origin of nucleolar components: a model for nucleolar RNA function.


Composition of nucleoli isolated from mammalian cells.


Progress report on the characterization of nucleoli from guinea pig liver.


Composition of the nucleolus as a basis for views on its function.


Autoradiographic studies of transfer RNA metabolism in Vicia faba root-tip cells.


Synthesis of basic proteins and cellular RNA species during sea urchin development.


Diversity and variation of the nucleolar organizing regions in chironomids.


Changes in nucleolar ultrastructure associated with differentiation in the root apex.


Problems in the developmental cytogenetics of nucleoli in Xenopus.


Autoradiographic studies of RNA and protein synthesis in anucleolate Xenopus embryos.


Localization of the ribosomal DNA complements in the nucleolar organizer region of Xenopus laevis.


On the chromosomal distribution of DNA complementary to ribosomal and soluble RNA.


The nucleolus--retrospect and prospect.

The nucleolus--retrospect and prospect.


Panel on ribosome biogenesis.

Panel on ribosome biogenesis.