Report of the nucleolus nomenclature committee.


Ultrastructure and mode of formation of the nucleolus in plant cells.


Morphology, structure, and dynamics of the nucleolonema.


International symposium on the nucleolus--its structure and function. Introduction.


Learning of a generalized response class in mentally retarded individuals.


Adult retardates' responsiveness to recordings as a function of music therapist participation.


Cancer chemotherapy studies: cytoplasmic barrier in malignant epidermal cells against the effect of colchicine. An electron microscopic study in mice.


Social competence of school and non-school trainable mentally retarded.


Psychological correlates in galactosemia.


Discrimination of good and poor retarded workers with the Hand Test.


Incentives and instructions as controlling variables of productivity.


Reliability of selected auditory responses of normal hearing mentally retarded children.


Sex-linked spastic paraplegia.

Sex-linked spastic paraplegia.


Patterns of family crisis related to reacceptance of the retardate.


Personality adjustment, self attitudes, and anxiety differences in retarded adolescents.


Mental retardation: who says what to whom...


The relationship between intelligence and sensorimotor proficiency in retardates.


Intelligence, the Bender-Gestalt Test, and reading achievement.


Sociometric groupings among educationally subnormal children.


Attitudes toward special education and the handicapped in two community groups.


Parental attitudes toward mental retardation.


Association of characteristics of retarded patients and their families with speed of institutionalization.


Two cases with a C-group ring autosome.

Two cases with a C-group ring autosome.


Familial spastic paraplegia with amyotrophy of the hands.


The effect of partial exclusion of certain matings and restriction of their average family size on the genetic composition of a population.


RNA synthesis in exponentially growing tobacco cells subjected to a step-down nutritional shift.


Synthesis of 28-S RNA in the nucleolus.

Synthesis of 28-S RNA in the nucleolus.


On the mechanism of hormone action. VI. Increase in template activity of ribonucleic acid from isolated nuclei incubated in the presence of hormone.


[14C]leucine incorporation into brain ribosomes.


Amino acid incorporation into protein by aseptic cell-free systems from tomato cotyledons and leaves.


The regulation of amino acid incorporation into thyroid protein: evidence that thyroxine and iodide inhibit protein synthesis at a ribosomal site.


Stimulation of polyamine synthesis in relation to nucleic acids in regenerating rat liver.


Some alternatives to sucrose for density gradient sedimentation.


Binding of alkali metal ions to polynucleotides.


The isonicotinyl hydrazones of nucleosides and their phosphorylated derivatives.


Pseudouridine residues resistant to cyanoethylation in yeast transfer ribonucleic acid.


Polyribosomes from calf-lens epithelium.


The resistance of Micrococcus radiodurans to ultraviolet radiation. 3. A repair mechanism.


Structure of nucleohistone. I. Hydrodynamic behaviour.


The average critical value method for adjudging relative efficiency of statistical tests in time series regression analysis.


Structure of nucleohistone. II. Thermal denaturation.


Bayesian comparison of means of a mixed model with application to regression analysis.


The orthogonal polynomials of power series probability distributions and their uses.


Linear estimates with polynomial coefficients.


Maximum-likelihood paired comparison rankings.


Testing for homogeneity. II. The Poisson distribution.


Correlation of ranges of correlated deviates.


A simple example of a comparison involving quantal data.


Some Monte Carlo results on the power of the F-test under permutation in the simple randomized block design.


Iterative maximum-likelihood estimation of the parameters of normal populations from singly and doubly censored samples.


Use of range in testing heterogeneity of variance.


Alternative tests for heterogeneity of variance; some Monte Carlo results.


Statistics connected with the uniform distribution: percentage points and application to testing for randomness of directions.


Bivariate generalizations of Neyman's type A distribution.


On the distributions of the range and mean range for samples from a normal distribution.


On the use of Patnaik type chi approximations to the range in significance tests.


A persistence problem in renewal theory: Robert the Bruce's spider.


The curve through the expected values of ordered variates and the sum of squares of normal scores.


Asymptotic expansions for the moments of the distribution of correlation coefficient.


A comparison of some Bayesian and frequentist inferences. II.


Spectral factorization of multiple time series.


Unequal group variances in the fixed-effects one-way analysis of variance: a Bayesian sidelight.


Table of 0-1 percentage points of Behrens's d.


A conservative test for the concurrence of several regression lines and related problems.


Approximations to the maximum-likelihood estimator using grouped data.


Some relationships among the von Mises distributions of different dimensions.


A necessary and sufficient condition for the square of a random variable to be gamma.


The correlation between variate-values and ranks in a doubly truncated normal distribution.


Large-sample sign tests for trend in dispersion.


A property of the mean deviation for the Pearson type distributions.


A generalization of Johnson's property of the mean deviation for a class of discrete distributions.


A Mendelian Markov process with binomial transition probabilities.


Closed sequential tests for binomial probabilities.


An application of sequential sampling to analytical surveys.


Models for the non-interactive joint action of a mixture of stimuli in biological assay.


On the homogenous birth-and-death process and its integral.


Distribution free tests based on the sample distribution function.


The oxidative dephosphorylation of phosphoryl esters derived from L-ascorbic acid.


Synthesis of phyllokinin, a natural bradykinin analogue.


Biochemical, genetical studies on host-parasite relationship: variation in fusaric acid production with different carbon sources.


Heterogeneity of catalase in blood of heterozygous cases of acatalasia.


Photochemical synthesis of amino acids from paraformaldehyde catalyzed by inorganic agents.


Studies on the metabolic fate of the C14 labeled methyl group of a methylhydrazine derivative in P815 mouse leukemia.


Biotin and fatty acid biogenesis in Aspergillus flavus.


The estrogenic and deciduogenic properties of some estra-1,3,5(10)triene-3,17-beta-diol derivatives.


Studies on modality segregation and second-order neurones in the dorsal funiculus.


Microelectrode studies of spontaneous potentials from chick embryo telencephalon in vitro.


Antagonism heterocyclic sulphonamides to the schistosomicidal effect of lucanthone.


Further observations on age differences in the effects of formalin on the canine brain in vitro.


The length-tension diagram of single muscle fibres of the crayfish.


Modulation during sleep of the spino-cerebellar evoked potentials.


Incorporation of [14C] amino acids into liver S-RNA of chick. Effect of orotic acid and vitamin B12.


Chromosome number and sex chromosome mechanism in some more species of the Indian mantids.


Table of replaceable amino acids in proteins.


The effect of the venom of the digger wasp Philanthus on the fast and slow excitatory and the inhibitory system in the locust muscle.


Pharmacological properties of a glycoalkaloidal fraction obtained from Solanum auriculatum Ait.


Acceleration of the cerebral dopamine turnover by chlorpromazine.


Gonadotrophic control of lamina propria and laminar collagen of testis.


Tumour immunity in rats following injection of homologous ribosomes.


Synthesis of 3-(2'-chloroethoxy)-6-formyl-delta-3,5-pregnadienes.  A new class of highly active anti-inflammatory corticosteroids.


Preliminary studies of the metabolism of 2-guanidinomethyl-1:4-benzodioxan sulphate (guanoxan).


Phosphorylation of thiamine in the intestinal wall during absorption in vivo.


Rate of uptake of 75Se, as selenourea-75Se, in rats in vivo.


Evaluation of the maternal role in survival of suckling mice.


Obsessional neurosis: a summary of psycho-analytic views as presented at the Congress.


Comment on Dr Ritvo's paper.

Comment on Dr Ritvo's paper.


Correlation of a childhood and adult neurosis: based on the adult analysis of a reported childhood case.


The interrelationship of phobia and obsessional neurosis.


Comment on Dr Zetzel's paper.

Comment on Dr Zetzel's paper.


Comment on obsessional neurosis and 'Frankie'.


Rhythm and organization in obsessive-compulsive development.


Some reflections on the Rat Man.

Some reflections on the Rat Man.


Factors and features of early compulsive formation.


The relationship between obsessive mechanisms and a state of self disturbance: depersonalization.


Obsessive compulsive façade in schizophrenia.


Persecutory anxiety in a four-year-old boy.


Comment on Dr Bychowski's paper.

Comment on Dr Bychowski's paper.


Criteria for interpretation in patients with obsessive traits.


Psychodynamic aspects of defence with comments on technique in the treatment of obsesssional neuroses.


Comment on the paper by Drs Axelrad and Brody.


Anxiety, socialization, and ego formation in infancy.


Structural derivatives of object relationships.


Comment on Dr Kernberg's paper.

Comment on Dr Kernberg's paper.


A re-evaluation of acting out in relation to working through.


Differences in individual development within a pair of identical twins.


Comment on Dr Limentani's paper.

Comment on Dr Limentani's paper.


Comment on Dr Naiman's paper.

Comment on Dr Naiman's paper.


The role of the superego in certain forms of acting out.


Life decisions during analysis.

Life decisions during analysis.


Role of phobic and counterphobic mechanisms and separation anxiety in schizoid character formation.


Comment on Mr Khan's paper.

Comment on Mr Khan's paper.


Fathers and daughters. The significance of 'fathering' in the psychosexual development of the girl.


Transference and a-transference phenomena.


The internalization of external conflict.


The intrapsychic and communicative aspects of the dream. Their role in psycho-analysis and psychotherapy.


Psychodynamic factors in acute myocardial infarction.


On weeping.

On weeping.


The mother's contribution to infantile transvestic behaviour.


Summary of discussion remarks on Dr Löfgren's paper.


A transvestite boy and a hypothesis.

A transvestite boy and a hypothesis.


The first born child, male. Vicissitudes of preoedipal problems.


Psycho-analysis and nosology.

Psycho-analysis and nosology.


Transference outside the psycho-analytic situation.


Development of psycho-analysis in India.


A further study of the effects of subliminal aggressive stimulation on thinking.


Profiles of family interaction systems.

Profiles of family interaction systems.


A self-report scale for process-reactive schizophrenia.


Phobic anxiety and its treatment.

Phobic anxiety and its treatment.


Importance of pathological laughing and/or crying as a sign of occurrence or recurrence of a tumor lying beneath the brainstem.


Natural levels of lead-210, polonium-210 and radium-226 in humans and biota of the Arctic.


Isotopically labelled macromolecules in biological research: dextran labelled with radioactive iodine.


In vitro destruction of skeletal muscle by sensitized cells.


Water-soluble factors with vitamin K activity from pig liver and from Fusiformis nigrescens.


Dependence of synaptic transmission on protein metabolism of nerve cells: a possible electrokinetic mechanism of learning?


Goitrogenic activity of cassava (a staple Nigerian food).


Taxonomic implications of 'myxovirus'.

Taxonomic implications of 'myxovirus'.


A new molluscicide, N-tritylmorpholine.

A new molluscicide, N-tritylmorpholine.


Isolation of a pre-viral deoxyribonucleic acid.


Mechanistic interpretation of empirical enzyme rate equations.


Loss of adenine during the hydrazine degradation of deoxyribonucleic acid.


Alkaloids as possible intermediaries in plant metabolism.


Significance and regulation of methaemoglobinaemia.


Production of coumarins by Phytophthora infestans.


Temporary alteration of the behavioral repertoire of a hermit crab.


Colonization of fresh waters in the Republic of South Africa by Lymnaea columella Say (Mollusca: Gastropoda).


Plasticity of reactions to light in frogs and a possible role for the pineal eye.


Phosphorus metabolism and auxin action.

Phosphorus metabolism and auxin action.


Respiratory changes during electrical stimulation of rhinencephalic structures in the foetal guinea-pig.


Failure of thymectomy in new-born guinea-pigs to influence contact sensitization.


Reciprocal influences of the ventromedial and lateral hypothalamic nuclei on blood glucose level and liver glycogen content.


Hypo-osmotic re-absorption due to active salt transport in perfused collecting ducts of the rat renal medulla.


Inhibition of haemagglutination by benzylpenicillin adsorbed on erythrocytes.


Nature of haemoglobin M-Oldenburg.

Nature of haemoglobin M-Oldenburg.


Phosphoglucomutase polymorphism: an unusual type in Negroes.


Effect of centrifugation of the eggs on the sex of Carausius morosus Br.


Reciprocal genetic changes in mycobacterial host-virus systems: effect of lysogeny on the phage.


Comparative gel-electrophoretic investigation of the protein patterns of Septoria species.


Control of time estimation by a chemical clock.


'Significant' and 'highly significant'.

'Significant' and 'highly significant'.


Cicatricial entropion of the upper eyelid. A modification in the operation.


Implications of 1965 legislation on local mosquito control operations.


Recent water management research.

Recent water management research.


Mosquito problems in agriculture.

Mosquito problems in agriculture.


Preventive control aspects in urban areas.


Aquatic nuisance potentials in the development of San Mateo County.


Applied ecology and the mosquito prevention program.


Cytoplasmic incompatibility as a means of eradication of Culex pipiens L.


California Mosquito Control Association, Inc. Statement of research policy.


California Mosquito Control Association, Inc. Address.


Ecological studies of California anophelines--a preliminary report.


Potential invertebrate predator-prey relationships in a rice field habitat.


Population fluctuations of threadfin shad, Clear Lake gnat larvae, and plankton in a lake county farm pond 1961-1965.


Snipe flies (Symphoromyia) attacking man and other animals in California.


Newer collecting methods for vectors of arboviruses.


Electron capture gas chromatography as a tool in mosquito control.


Research on mosquito resistance to insecticides at the University of California, Riverside.


The introduction of helicopters into California mosquito control.


Solution to the phosphate resistance problem.


Mosquito larvicide susceptibility surveillance--1965.


Mosquito control. Sacramento Valley region.


Mosquito control. California coastal region.


Mosquito control. Southern San Joaquin region.


Mosquito control. California southern region.


Mosquito control activities in Louisiana.


Mosquito control activities in Utah--1965.


Expanding aircraft usage for mosquito control. Expedited surveillance by helicopter.


Expanding aircraft usage for mosquito control. Comments on low-volume spraying.


Expanding aircraft usage for mosquito control.


California Mosquito Control Association, Inc. Presidential message.


Complications  of blood transfusion.

Complications  of blood transfusion.


Fractured neck of femur and subsequent gas gangrene.


Biosynthesis of skimmianine.

Biosynthesis of skimmianine.


Carcinostatic agents. XVI. Inhibition of purine biosynthesis and of tetrahydrofolic acid formylase by beta-4-methoxybenzoyl-beta-bromoacrylic acid.


I.Q. scores and the problem of classification. A comparison of the W.A.I.S. and S-B, form L-M in a group of subnormal and psychopathic patients.


The use of the Maudsley Personality Inventory on university students.


Symptom questionnaire validity in assessing the need for psychiatrists' care.


Factors predisposing to a placebo response in new out-patients with anxiety states.


The relationship of psychiatric psychosomatic and organic illness in a general practice.


Geriatric admissions to a mental hospital.


A comparison of psychiatric admissions from prison and other sources.


Population trends in a mental hospital. A four-year follow-up review of a hospital population.


Shortened treatment in a child guidance clinic. The results in 119 cases.


Amphetamine intoxication and dependence in admissions to a psychiatric unit.


Pain and the psychiatrist.

Pain and the psychiatrist.


A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism.


The diarrhea of travelers: incidence in foreign students in the United States. To ascertain whether foreign visitors to the United States experience the diarrhea of travelers, 215 foreign students matriculating at the University of California, Los Angeles, were interviewed. The attack rate of diarrhea was 14.0 per cent during the first month after arrival in the United States. In a comparison group of 238 U.S. students, the attack rate of diarrhea in one month was 8.4 per cent. The difference in attack rate was not statistically significant. The diarrheal episodes reported by the foreign students were less abrupt in onset, less severe and of longer duration than the usual diarrhea of travelers. The typical severe explosive diarrhea of short duration usually described as "diarrhea of travelers" was not encountered among the foreign students in this study. The occurrence of diarrhea was not associated with the age, sex or race of the students, with the location of eating places, with the geographic area from which the foreign students came or with any characteristics of the trip to the United States. In the group of U.S. students there was an increased incidence of diarrhea among students who came from outside California to Los Angeles.


The uptake and excretion of thyroxine, triiodothyronine and iodide in bullfrog tadpoles after immersion or injection at 25 degrees and 6 degrees.


The basis for the limit on whole-body exposure--experience of radiologists.


Psycho-analysis and medical practice.

Psycho-analysis and medical practice.


Mesodermal alterations induced by hypervitaminosis A.


Histology of larval eye-antennal disks and cephalic ganglia of Drosophila cultured in vitro.


Teratogenic action of the thyroid stimulating hormone and its interaction with trypan blue.


Ultrastructure of the blastopore cells in the newt.


Inhibition by alpha-methyl-norvaline of the uptake of valine and leucine into haemoglobin of the chick embryo.


Whisker growth after removal of the dermal papilla and lengths of follicle in the hooded rat.


pH-dependence of the inducing activity of lithium ion.


Trypan blue induced teratogenesis of rat embryos cultivated in vitro.


Altered patterns of RNA metabolism in liver cells following partial hepatectomy and thioacetamide treatment.


Synthesis of ribonucleic acid by human chromosomes and a possible mechanism of its repression.


The pathogenesis of Candida tropicalis infections in mice.


Dehydrogenase activity and mucosal measurements in jejunal biopsies from patients with gastrointestinal diseases.


Multiple-spike discharge evoking after-depolarizations in the slowly adapting stretch receptor neuron of the lobster. II. The slow after-depolarization.


Evaluation of the maximum-likelihood estimator where the likelihood equation has multiple roots.


Correlation in a singly truncated bivariate normal distribution. 3. Correlation between ranks and variate-values.


Some factors influencing the revival of heat-damaged Staphylococcus aureus.


Streptomyces isolates capable of lysing Candida albicans.


Comment on Dr. Morgenthaler's paper.

Comment on Dr. Morgenthaler's paper.


On the psycho-analytic concept of identity.


The relation of anal masturbation to projective identification.


Intestinal tuberculosis with fistula in ano.


Anticholinergic drug-induced delirium: experimental modification, quantitative EEG and behavioral correlations.


Protection of phagocytized bacteria from the killing action of antibiotics.


What should we expect from state government in support of local mosquito control?


Head injuries and the anaesthetist.

Head injuries and the anaesthetist.


Arfonad test for predicting blood pressure response to spinal anesthesia.


Buschke-Lowenstein tumor of the penis.

Buschke-Lowenstein tumor of the penis.


Local excision in transitional cell tumors of the upper urinary tract.


Localization and efficiency of interstitial chromic phosphate in the bladder.


Experiences with ureteral carcinoma in sito detected during operations for vesical neoplasm.


Disulfiram and tumor inhibition.

Disulfiram and tumor inhibition.


Applications of the scintillation camera in urology.


Observations on the relationship of the pineal gland to environmental and biological phenomena.


Residual urine volume in normal male subjects.


Cholinesterase activity of isolated giant synapses.


The effect of hematoporphyrin and light on human platelets. 3. Release of potassium and acid phosphatase.


Difference between medullary and cortical thymic lymphocytes of the pig in their response to phytohemagglutinin.


Contraction of protoplasm. II. Theory: anodal vs. cathodal in relation to calcium.


Orthophosphate excretion as related to RNA metabolism in Tetrahymena.


Influence of ions and tonicity on RNA metabolism in Tetrahymena pyriformis.


Delayed inhibition of DNA synthesis in mouse jejunum by low doses of actinomycin D.


Sodium transport inhibition by selective mitochondrial inhibitors in the urinary bladder of the toad.


Temperature dependent RNA decay in Tetrahymena.


Bio-assays of medicaments for the control of dentobacterial plaque, dental caries, and periodontal lesions in Syrian hamsters.


Peridontal pathosis in man. XVI. Effect of glucose drinks upon sulcus depth.


Anti-rabies vaccine employing a dental anesthetic as the vehicle: pilot study.


Convulsive properties of four local anesthetic preparations.


Measurement of tetracycline incorporated in enamel and dentin.


Retarded incisor eruption and general characteristics of the vitamin A-deficient rat.


Simple maneuver to overcome total laryngospasm.


The quantitative histochemistry and cytochemistry of lactic dehydrogenase and NADH-2-tetrazolium reductase in human aortic wall.


The lymph-node permeability factor: a possible mediator of experimental allergic thyroiditis in the rat.


An electron-microscope and histochemical study of melanosis coli.


Effects of nephrotoxins and ischaemia in experimental haemoglobinuria.


Viability of BHK21 line of hamster fibroblasts after storage at sub-zero temperatures.


Haemolysins in coagulase-negative staphylococci.


The antigenic interrelationships of live cholera vaccines and a method of bioassay.


Electron microscopy of a human liver in Weil's disease (leptospirosis icterohaemorrhagica).


Hepatic vascular changes in human and experimental cirrhosis.


An electron-microscope study of reovirus type 2 in L cells.


The chemical reactions of influenza virus proteins.


Arthritis produced by intra-articular injections of streptolysin S in rabbits.


The hypotensive action of puffer fish toxin.


Adipose atrophy of the exocrine pancreas.


Multifocal histiocytosis in the lungs of rats.


Malignant transformation of a non-osteogenic fibroma of bone.


The use of sodium aurothiomalate in the eradication of pleuropneumonia-like organisms (PPLO) from a chronically infected strain of hamster kidney cells (BHK 21 C13).


Effect of route of entry of Candida albicans on the histogenesis of the lesions in experimental candidosis in the mouse.


A pathological presomite human embryo.

A pathological presomite human embryo.


Pigmentation of Staphylococcus aureus.

Pigmentation of Staphylococcus aureus.


Failure to induce chemical carcinogenesis in skin of guinea-pigs after production of auto-antibody to skin.


Onsager reciprocal relations in complex membranes.


Cross-over effect in homozygosity by descent.


The degree of coupling and its relation to efficiency of energy conversion in multiple-flow systems.


Electron aspects of the mode of action of the mitomycin molecule.


Local blood flow in kidney tissue by heat clearance measurement.


The information content of DNA.

The information content of DNA.


Inhibition of parallel flux and augmentation of counter flux shown by transport models not involving a mobile carrier.


Mathematical aspects of renal function: the dependence of solute reabsorption on water reabsorption, and the mechanism of osmotic natriuresis.


Mathematical aspects of renal function: reabsorption of individual solutes as interdependent processes.


The semi-empirical SCF treatment of sigma-pi system. I. Peptide molecule.


On interpreting compartmentalization experiments.


Species-diversity and pattern-diversity in the study of ecological succession.


The antagonism of oxotremorine effects in the mouse by thymoleptics.


Active transport of D-mannose in the small intestine.


Complete anosmia--the absence of olfaction at primary and accessory olfactory areas.


The oxidation-reduction potential of human haemoglobin F.


Atrophic changes and adrenal cortical lipids.


Induction of thymidine kinase by aflatoxin.


Thermodynamics of solubilization of aromatic compounds by bovine serum albumin.


Base composition of the newly synthesized RNA in the two ribosomal RNA components of rat liver.


The possible role of thyroid monoamine oxidase in iodothyronine synthesis.


Muscular contraction by implanted stimulators.


Noise in electromagnetic flowmeters.

Noise in electromagnetic flowmeters.


An explanation of the travelling wave theory of hearing.


A feedback model of the neuron for the study of small neuron networks.


A three-state myo-electric control.

A three-state myo-electric control.


A comparison of linear and non-linear characterizations of impedance spirometry data.


A system for generating a stable d.c. baseline and suppressing noise when processing pulsed signals of physiological and other origin.


A temperature controlled microscope slide.


A useful rat head holder for cerebral surgery.


Improving the efficiency of an artificial kidney: the use of increased dialysate flow rates.


Measuring crosstalk and minimizing it in multiple stimulation arrangements.


Engineering and physical science in relation to the life sciences.


Adrenergic beta-receptor blockade and the effect of hyperventilation on the electrocardiogram.


Deviation from basal state during catheterization of the right and left sides of the heart.


On the repeatability of submaximal work tests and the influence of body position on heart rate during exercise at submaximal work loads.


Quantitation of erythropoiesis by a new method. I. Studies on healthy subjects.


Acceleration of fibrin polymerization by dextran and ficoll. Interaction with calcium and plasma proteins.


The fat content of leg muscles and its influence on the 133xenon clearance method of blood-flow measurement.


Separation of urinary coproporphyrin isomers 1 and 3 by thin-layer chromatography. Studies in healthy subjects and patients with myocardial infarction.


Coupled enzyme reactions in polyacrylamide gels: isoenzymes of serum ATP: creatine phosphotransferase.


Rapid identification of barbiturates in blood by thin layer chromatography on microscope slides.


Separation of inulin from chemically interfering dextrans by gel filtration.


Intracardiac recording of monophasic action potentials in the human heart.


Distribution of cystathionine in human brain.


The effect of satiation on the value of the conditioned salivary response.


Protection of the fear-eliciting capacity of a stimulus from extinction.


Differentiation learning in rabbits with lesions of the frontal cortex or the hypothalamus.


Effects of frontal lobe lesions on urinary bladder function in dogs. Studies with new techniques of cystometry.


Is the ventromedial nucleus of the hypothalamus a "satiation center"?


Disturbances of motor conditioned behaviour following bilateral ablations of the precruciate area in dogs and cats.


Viscosimetric determination of cellulase activity in the intestine of the sea urchin: reaction mechanism and equilibrium constant for cellulase stabilization with calcium.


Paper electrophoretic quantitation and measurement of the radioactivities of labelled sulphur amino acids as their oxidation derivatives.


Effect of ethanol on rat liver. 3. Lipid composition of liver mitochondria from rats after prolonged alcohol consumption.


Fluorescence studies on some 6,7-substituted 3,4-dihydroisoquinolines formed from 3-hydroxytyramine (dopamine) and formaldehyde.


Entrapment of enzymes and microorganisms in synthetic cross-linked polymers and their application in column techniques.


Photoelectron spectroscopy of fatty acid multilayers.


Studies on sphingosines. II. The chemical structure of phytosphingosine of human origin and a note on the lipid composition of the yeast Hansenula ciferrii.


Metabolic changes in arterio-mesenteric syndrome and their relation to upper abdominal diseases.


Significance of the presence of Schistosoma haematobium ova in rectal snips taken from bilharzial cases.


Caesarean section in infected and potentially infected cases with special reference to two cases of peritonitis due to perforated appendix.


Positive conditioning in nocturnal enuresis.


Congenital malformation in U.A.R.

Congenital malformation in U.A.R.


The effect of Cannabis indica on carbohydrate metabolism in rabbits.


Study of the effect of combining anabolics with steroids in long-term therapy of bronchial asthma.


Estimation of the dose-response curve of subcutaneously injected carbon tetrachloride in mice.


Physiological jaundice in Egyptian neonates.


Conditioned reinforcement in second-order schedules. Pigeons responded under a schedule in which food was presented only after a fixed number of fixed-interval components were completed. Two such second-order schedules were studied: under one, 30 consecutive 2-min fixed-interval components were required; under the other, 15 consecutive 4-min fixed-interval components were required. Under both schedules, when a 0.7-sec stimulus light was presented at completion of each fixed interval, positively accelerated responding developed in each component. When no stimulus change occurred at completion of each fixed interval, relatively low and constant rates of responding prevailed in each component; a similar result was obtained when a 0.7-sec stimulus change occurred at completion of each fixed interval except the one which terminated with primary reinforcement. The 0.7-sec stimulus correlated with food delivery was an effective conditioned reinforcer in maintaining patterns of responding in fixed-interval components despite low average frequencies of food reinforcement.


Flicker thresholds as determined by a modified conditioned suppression procedure. Critical flicker fusion frequencies were determined as a function of stimulus intensity for three White Carneaux pigeons using a modified conditioned suppression paradigm as a threshold procedure. Critical frequencies ranged from 6 cps for the lowest intensity of 0.0014 ml to 77 cps for the maximum intensity of 41.86 ml.


Computer control of operant behavior experiments via telephone lines.


A "direction of movement" memory.

A "direction of movement" memory.


A comparison of two psychophysical methods using animals. A discrimination box containing two levers with a light above each was used to train eight rats to press beneath the brighter light for a milk reinforcer. The brighter light was held constant and the comparison light was varied to produce 12 brightness differences. The animals were run under two experimental methods: the block method in which each brightness level comparison was presented for a block of 11 contiguous trials, and the staircase method in which the sequence of brightness comparisons was determined by the correctness of the response on the preceding comparison. The block method produced a smaller differential brightness threshold and a larger change in discrimination performance for stimulus magnitude changes than did the staircase method.


Variable-interval punishment during variable-interval reinforcement. Variable-interval punishment was superimposed on a variable-interval food reinforcement baseline for three groups of rats. The value for the variable-interval punishment schedule was the same as that for the variable-interval food reinforcement schedule, although the two schedules were programmed independently. The three groups were Variable Intervals 0.5, 1, and 3 min. Little or no suppression occurred in the three groups at mild (0.2 and 0.4 ma) intensities of punishment, but at 0.6 ma, complete suppression occurred almost uniformly. During continued punishment, there was no consistent recovery toward the pre-punishment baseline at suppressing intensities of punishment. After punishment was discontinued, recovery from suppression was more rapid the lower the punishment intensity, and the lower the value of the variable-interval schedules of reinforcement and punishment.


A new device for programming contingencies between drinking, running, and lever-pressing.


Discriminative echolocation in a porpoise. Operant conditioning techniques were used to establish a discriminative echolocation performance in a porpoise. Pairs of spheres of disparate diameters were presented in an under-water display, and the positions of the spheres were switched according to a scrambled sequence while the blindfolded porpoise responded on a pair of submerged response levers. Responses which identified the momentary state of the display were food-reinforced, while those which did not (errors) produced time out. Errors were then studied in relation to decreased disparity between the spheres. As disparity was decreased, errors which terminated runs of correct responses occurred more frequently and were followed by longer strings of consecutive errors. Increased errors and disruption of a stable pattern of collateral behavior were associated. Since some sources of error other than decreased disparity were present, the porpoise's final performance did not fully reflect the acuity of its echolocation channel.


A versatile and reliable printing counter.


A conditioned reinforcer maintained by temporal association with the termination of shock. Two experiments were conducted to determine whether a stimulus can be established as a positive conditioned reinforcer by associating it with the termination of shock, but without training the animal to make any response in its presence. In the first, six rats were conditioned to press a bar to terminate shock on a variable ratio schedule; white noise was then substituted as the immediate consequence, with the shock terminating 30 sec after the last press in its presence. It was found that the rate of pressing in the absence of noise depended on the contingency between the pressing and the noise. The second experiment sought to determine whether the difference in rates before and after the onset of the noise was due to the reinforcement of prior responding by the onset of the noise or to the suppression of subsequent responding by differential reinforcement of competing behavior. Six more rats were trained in the same manner, but with shock terminating 30 sec after the onset of the noise, regardless of what the animal did in its presence. Again the rate was higher before the onset of the noise, indicating that pressing was indeed maintained by the noise as a conditioned reinforcer.


Human, free-operant avoidance of "time out" from monetary reinforcement. To assess the aversive effects of withdrawing monetary reinforcement, human subjects were exposed to a free-operant avoidance procedure in which periods of no reinforcement occurred if the subject failed to respond, and each response postponed withdrawal of reinforcement. Avoidance behavior was developed either through specific instructions about the consequence of responding or through preliminary escape-avoidance training. In all cases, rates of response were found to be a positively accelerated function of decreases in the duration by which responding postponed reinforcement withdrawal. The findings with respect to the function relating avoidance behavior to the interval of postponement were viewed as similar to those obtained when shock is used as the aversive event in free-operant avoidance conditioning.


Investigations of a mirror-image transfer effect in pigeons. In two separate experiments, pigeons trained binocularly to peck a key on which an oblique line (e.g., 60 degrees counter-clockwise rotation from horizontal) was projected yielded bi-modal angularity generalization gradients in extinction, with peaks of responding at both the training stimulus and its mirror image (in this case 120 degrees ). This mirror-image transfer effect may be analogous to an "octave effect" in auditory generalization, but Mello's finding of a mirror-image reversal transfer effect following monocular training in pigeons suggests an alternative interpretation.


The effect of multiple S-delta periods on responding on a fixed-interval schedule. V. Effect of periods of complete darkness and of occasional omissions of food presentations. In pigeons under fixed-interval schedules of reinforcement, responding during most of the interval can be suppressed by stimulus conditions never present when a response is promptly followed by reinforcing stimuli. When the external stimuli obtaining immediately before reinforcement are presented during brief probe periods in the course of the interval, the rate of responding in the probe depends on the temporal position of the probe during the interval; the rate of responding is lower during a probe early in the interval than during one late in the interval. The present experiments show that the temporal dependency still holds (1) in birds with no experience under unmodified fixed-interval schedules, (2) when the time between probes is spent in complete darkness, and (3) when food presentations are omitted at the end of 50% of intervals. The results strengthen and extend the conclusion from previous studies that the time relations themselves are the primary control of rate of responding under fixed-interval schedules of reinforcement.


The reinforcement of least-frequent interresponse times. A new schedule of reinforcement was used to maintain key-pecking by pigeons. The schedule reinforced only pecks terminating interresponse times which occurred least often relative to the exponential distribution of interresponse times to be expected from an ideal random generator. Two schedule parameters were varied: (1) the rate constant of the controlling exponential distribution and (2) the probability that a response would be reinforced, given that it met the interresponse-time contingency. Response rate changed quickly and markedly with changes in the rate constant; it changed only slightly with a fourfold change in the reinforcement probability. The schedule produced stable rates and high intra- and inter-subject reliability, yet interresponse time distributions were approximately exponential. Such local interresponse time variability in the context of good overall control suggests that the schedule may be used to generate stable, predictable, yet sensitive baseline rates. Implications for the measurement of rate are discussed.


Serial discrimination-reversal learning with and without errors by the California sea lion. A sea lion under water performed virtually without errors on a series of three form-discrimination reversals. Significant training requirements were the combining of a previously well-established size cue preference with the nonpreferred form cue, followed by the gradual reduction of the size cue until it was completely eliminated. Orienting responses reached a peak and then decreased during progressive-dimensional-change training, suggesting critical stages in the transition of attention from the size dimension to the form dimension. Further experimentation revealed that intensive training during these critical stages obviated the need to reduce very gradually the size cue. Without special training sea lions make perseverative errors on a series of form-discrimination reversals. "Emotional" or nontest-oriented behavior was associated only with the occurrence of successive errors.


A restraining device for use in the measurement of eyelid responses in laboratory rats.


Digital methods of producing random and variable time intervals.


An illuminated rat-lever using an electroluminescent lamp.


Ways to improve the stature of urology in the medical community.


A study of anophthalmia in an adult.

A study of anophthalmia in an adult.


Enzyme histochemistry of the prenatal development of human deciduous teeth. I. Alkaline phosphatase, acid phosphatase and unspecific AS-esterase.


Investigations of the thyroid of deer and roe-bucks.


Overweight in adolescents--a complex problem.


Malignant meningeal melanoma in a 3-year-old boy. A case report.


Intestinal absorption and mucosal histology in iron deficiency anaemia in children.


Chronic moniliasis, pyodermia and impaired capacity to form gamma-M antibodies.


An electronic computer for venous occlusion volume plethysmography of the human digit.


Stress-strain studies in cadaveric human tendon and an anomaly in the Young's modulus thereof.


Microvoltmetric electrocardiography (MECG)--some clinical and experimental applications.


On-line computer monitoring of the seriously-ill patient.


The use of conducting paint for recording hatching times.


A rat paw plethysmometer for single-handed operation.


Increased dependability of clinical electrocardiographs by automatic protection of the heated stylus.


A heart rate meter for measurement of instantaneous and average rates.


Local ground-level air concentrations of lead-210 at Winchester, Massachusetts.


Alpha-radioactivity of human blood.

Alpha-radioactivity of human blood.


Interlocus specificity for chemical mutagens in Aspergillus nidulans.


Location of the mechanism of active transport of sodium across the frog skin.


Effect of neonatal thymectomy on the induction of papillomata and carcinoma by 3,4-benzopyrene in mice.


Effect of sporidesmin on lipid metabolism in rabbits.


Separation of two kinds of polymerase from Alcaligenes faecalis.


Complex formation and carcinogenicity of aromatic compounds.


Antagonism between alloxan and caffeine.


Quantitative determination of purine derivatives in the presence of denatured protein.


Inhibitory action of glucides on trypsin activity.


Tumour-promoting and tumour-inhibiting fractions from tumours.


Chemical transmission at the insect excitatory neuromuscular synapse.


Effect of microwave radiation on birds.

Effect of microwave radiation on birds.


Variations in the plasmalogen content of mammalian heart muscle.


Action of mecholyl on the respiration of cardiac muscle in vitro.


Laser lesions: changes in retinal excitability.


An anti-viral drug (M and B 7714) and bilirubin conjugation.


Toxicity of dimethyl sulphoxide to the goldfish, Carassius auratus.


The quantitative relationship of the Rh-like (LW) and D antigens of human erythrocytes.


Variation of red cell acid phosphatase in two species of kangaroos.


Fibrinogen as a co-factor in the reaction of platelets with kaolin.


Synthesis of antibody in vitro by lymph node fragments using absorbable gelatin sponges.


Cytotoxic effects of antisera against dye-protein complexes.


Histochemical observations on the lipids of sound human dentine.


Are iodotyrosines normal constitutents of plasma?


Inhibition of oxygen consumption of liver homogenates from mice injected with radioprotectors in the presence of pyruvate.


Pesticide residues in the Irish environment.


Pregnancy failure in laboratory mice after multiple short-term exposure to strange males.


Some observations on staphylococcal pigmentation.


Effect of bacitracin on in vitro phagocytosis.


Spontaneous alternation and exploration in rats.


An acoustic factor in letter cancellation.


A steering device for selective angiography and some vascular and enzymatic reactions observed in its clinical applications.


Superficial fungal infections in an area of lowland New Guinea. Clinical and mycological observations.


Certain epidermal cellular anomalies with discussion, where possible, of their significance or method of their formation.


Routine diagnostic mycology.

Routine diagnostic mycology.


Seborrhoeic keratoses.

Seborrhoeic keratoses.


Papillomatous granulomatosis (Florid Oral Papillomatosis).


Letterer-Siwe's disease. Report of a case, with autopsy.


Pityriasis rubra pilaris treated with methotrexate.


Recent epidemiological studies of lung cancer mortality cigarette smoking and air pollution, with discussion of a new hypothesis of causation.


Cancer of the uterine cervix in Aberdeenshire. Epidemiological aspects.


Cancer of the uterine cervix in Aberdeenshire. Aetiological aspects.


Environment and heredity factors in carcinoma of the stomach.


High incidence of breast cancer in thyroid cancer patients.


Submucous fibrosis of the oral cavity. Histomorphological studies.


Infra-red in the diagnosis of a lump in the breast.


Interstitial irradiation of the pituitary gland for advanced carcinoma of the breast using the trans-ethmoidal approach.


Alcohol shift and alcohol dysphagia in Hodgkin's disease, carcinoma of cervix and other neoplasms.


The effect of sex and of sex and thyroid hormones on the induction of cancers in the salivary glands of rats.


Experimental studies on the aetiology of "Kangri cancer".


Beryllium induced sarcomas of the rabbit tibia.


Analysis of the cell population kinetics of transplanted tumours of widely-differing growth rate.


The biology of large solid tumours regressing with nitrogen mustard treatment: a study of the mouse plasma cell tumour Adj-pc-5 and the Walker carcinosarcoma 256.


The growth of Ehrlich's ascites carcinoma in C3H mice and in mice of an unrelated closed colony. Variation in survival time.


The growth of Ehrlich's ascites carcinoma in C3H mice and in mice of an unrelated closed colony. Variation in tumour growth, cytology and ascites formation.


The growth of Ehrlich's ascites carcinoma in C3H mice and in mice of an unrelated closed colony. Splenomegaly following intraperitoneal transplantation.


Antigenicity of carcinogen-induced and spontaneous tumours in inbred mice.


The effect of intravenous fluids on the development on experimental tumour metastases: their effect on tumour cell aggregation.


Effect of chondroitin sulphate on the growth of solid Ehrlich ascites tumour under the influence of hydrocortisone.


Distribution of new fluorene disulphonamido derivatives in rats with transplanted Walker carcinosarcoma.


Synthesis of antibiotics. I. Synthesis of N-substituted compounds of monochloroacylamide and their antitrichophyton effect.


Induction of tumours of connective tissue by repeated applications of 4-nitroquinoline N-oxide to mouse skin.


Azabenzomorphane and related compounds. IX. A synthesis of 3-benzyl-3,4,5,6-tetrahydro-2H-1,5-methanobenzo[d][1,3]diazocine. (Studies on the synthesis of heterocyclic compounds. CXLI).


Studies on optically active amino acids. IX. Studies on alpha-alkyl-alpha-amino acids. IV. Chemical correlation of absolute configuration of alpha-methylaspartic acid to isovaline.


Studies on optically active amino acids. X. Studies on alpha-alkyl-alpha-amino acids. V. Absolute configuration of biochemically active (-)-alpha-methyl-3,4-dihydroxyphenylalanine.


Hydrolysis of aryl beta-d-glucofuranoside by almond emulsin beta-glucosidase.


Studies on the pyrimidine derivatives and related compounds. XXXIX. On the oxidation products of 2-phenyl-4-(2-methyl-4-amino 5-pyrimidyl)methyl-5-methyl-6-(2-benzoyloxy or hydroxy)-ethyl-4H-1,4-thiazin-3(2H)-one.


Studies on pore structure of granules by mercury porosimetry.


Studies on diazabenzobicyclo-[3.3.1]nonane system. V. Nuclear magnetic resonance spectral studies on diazabenzobicyclo[3,3.1]nonane system.


Studies on digitalis glycosides. XXIV. Ring opening reaction of 14,15-epoxide with thiocyanic acid, and preparation of  3-beta-hydroxy-14-beta,15-beta-epithio-5-beta-card-20(22)-enolide.


Gas chromatography of catecholamines and related compounds.


Studies on herbicides and plant growth regulators. II. Synthesis and some reactions of 1-aryloxyacylpyrazoles.


Studies on constituents of medicinal plants. VII. The stereochemistry of paulownin and isopaulownin.


Thiosugars. 8. Synthesis of 1,2-dithio-beta-D-mannopyranose.


Deoxygenation of pyridine 1-oxide by means of benzyl alcohol.


Synthesis of 2,4-dithiouridine and 2-thiocytidine.


The structure of dendramine.

The structure of dendramine.


The structure of dendroxine. The third alkaloid from Dendrobium nobile.


The structure of dendramine(6-oxydendrobine) and 6-oxydendroxine. The fourth and fifth alkaloid from Dendrobium nobile.


Synthesis of guano-coenzyme A.

Synthesis of guano-coenzyme A.


Structural modification of coenzyme A by synthesis via thiazoline intermediate.


Considerations regarding the possible production of experimental allergic encephalomyelitis in dogs.


Ataxia-telangiectasia (Louis-Bar syndrome).


An anergic phase of disseminated sclerosis with psychotic course.


The bilharzial pigment in liver biopsies examined by the transparency technique as a criterion for the diagnosis of the pilharzial nature of hepatosplenomegaly.


A study of Egyptian epileptics with temporal lobe focus.


Cavernous haemangioma of the bladder. Case report.


Better results with a simplified technique in cystectomy (experience with 38 cases).


Hypertension as the only manifestation of a hypernephroma. (A case report).


Regional distribution of some chemical structural components of the human nervous system. I. DNA, RNA and ganglioside sialic acid.


Subacute inclusion body encephalitis. A histological and electron microscopical study.


Cytochemical structure of the human glia visualized by the reaction with thiamine pyrophosphate.


Modification of Fick's principle for the determination of relative shunts.


Blood gases and blood pH in spastic bronchitis in infants.


Dental and skeletal development of children with low birth weight.


The Paul-Bunnell test in different clinical types of infectious mononucleosis.


Blood plasma copper in pulmonary cancer and in chronic pulmonary infections.


Isotope scanning of the pancreas as a diagnostic aid in some cases of pancreatic diseases.


Lymphography in rheumatic diseases.

Lymphography in rheumatic diseases.


Information content of lateral planikymography in valvular and congenital heart diseases.


Chronic respiratory disease among old people in a Finnish rural area.


The schizophrenic patient in the community and his effect on the household.


Suicide and family disorganization.

Suicide and family disorganization.


Mental health training for overseas volunteer service.


Apgar test for the neurological assessment of newborns.


Psychosomatic histories in the relatives of male hospital chest unit patients with special reference to lung cancer.


Conjoint psychotherapy of married couples: a clinical report.


Nationalism, internationalism, and emotional maturity.


A comparison of results from the Peabody Vocabulary Test and Leiter International Performance Scale with children having functional articulatory disorders.


Some sources of help utilized by cerebral palsied college students.


Transformation of generalized inbreeding coefficient in components of pedigree.


Relation of suicide attempt and social structure in Kamakura, Japan.


Neuroelectric potentials derived from an extended version of Hodgkin-Huxley model.


Calculations of inbreeding coefficient and gene-set probability in diploid populations.


Relations among measures of language of cerebral palsied and of mentally retarded children.


Effect of type of mental retardation on three language measures.


Articulation of difficult speech sounds by two groups of retarded children.


Fluxes in passive, monovalent and polyvalent carrier systems.


The origin of life and the nature of the primitive gene.


A model of a growing steady state system.


Intellectual functioning of spastic cerebral palsied.


Studies in irreversible thermodynamics. 3. Models for steady state and active transport across membranes.


Studies in irreversible thermodynamics. IV. Diagrammatic representation of steady state fluxes for unimolecular systems.


Molecular theory of nerve potentials.

Molecular theory of nerve potentials.


Non-suppurative pericardial effusions.

Non-suppurative pericardial effusions.


The influence of metal ions on the hydrolysis of polyphosphates.


An investigation of a group of patients who have attended both the child and adult departments of the same psychiatric hospital.


Rod and ring chromosome cross-overs described by braid group.


Some comments on steady state transport of ions across a charged biological membrane.


A new type of cytotoxic immunosuppressive agent: 3-acetyl-5-(4-fluorbenzylidiene)4-hydroxy-2-oxo-2:5-dihydrothiophen.


Haemoglobin polymorphism in the orangutan and an animal with four major haemoglobins.


Some techniques for the electrical brain stimulation of small unrestrained animals.


Tuberculosis today.

Tuberculosis today.


Tabes dporsalis.

Tabes dporsalis.


Practical radiography.

Practical radiography.


Present status of the respiratory virus infections.


Lactate dehydrogenases in poikilotherms: definition of a complex isozyme system.


Protein biosynthesis in Trypanosomidae. I. In vivo incorporation of leucine-C14 in Trypanosoma cruzi.


Pathways of urea synthesis in the elasmobranch, Squalus acanthias.


The fatty acids of phycomycete fungi, and the significance of the gamma-linolenic acid component.


The effect of temperature on the membrane properties of neurons in the visceral ganglion of Aplysia.


Intermediary metabolism in Carcinus maenas.


The isolation and amino acid composition of the bone collagen in pleistocene mammals.


The effect of body size and temperature upon oxygen consumption of the cestode Schistocephalus solidus (Müller).


Air breathing in the teleost Symbranchus marmoratus.


Circadian period and phase-angle difference in chaffinches (Fringilla coelebs L.).


Temperature and the free-running circadian rhythm of the house finch.


The effects of cold, noradrenaline and adrenaline upon the oxygen consumption and carbohydrate metabolism of the young fowl (Gallus domesticus).


Anatomic angles determined from two radiographic projections. Instrument description and measurement techniques.


Cytologic, vascular, and histologic patterns of dysplasia, carcinoma in situ and early invasive carcinoma of the cervix.


Pacemaker activity and mitosis in cultures of newborn rat heart ventricle cells.


The effect of beta-2- thienylalanine upon RNA synthesis in the macrophage.


Circadian phase relationships of 3H-thymidine uptake, numbers of labeled nuclei, grain counts and cell division rate in larval urodele epidermis.


The effects of beta-2- thienylalanine upon protein synthesis in the macrophage.


Synthesis of macromolecules in epithelial cells of the cultured amphibian lens. I. DNA and RNA.


Action of ultraviolet radiation upon ciliary movement in Paramecium.


The role of newly synthesized RNA on nuclear histone synthesis by chicken immature erythrocytes.


Permanent cell lines of the marsupial mouse Antechinus swainsonii.


Occurrence of an inhibitory factor of ribosomal RNA synthesis in embryonic cells of Xenopus laevis.


Karyotype studies on a lymphoma (2731/L) resulting from reovirus type 3 infection of neonatal mice.


Actinomycin D or puromycin inhbition of cancer serum and estrone or thymidine-5-triphosphate induced cytokinesis in hamster multinucleated tumor cells.


Karyokinetic interference in Triturus following kinetin treatment.


Anomalous differentiation of melanin granules caused by thiouracil.


Changes in selective affinity following transdetermination in imaginal disc cells of Drosophila melanogaster.


The inhibition of nuclear RNA synthesis by added RNA.


The quantitative distribution pattern of deoxyribonucleic acid in cell cultures.


Late replication patterns of chromosomal DNA in somatic tissues of the Chinese hamster.


Studies on the modulation of catalase activity in mammalian cell culture.


Cellular differentiation in the anamniota. II. Oxygen dependency and energetics requirements during early development of teleosts and urodeles.


Cellular differentiation in the anamniota. IV. Relationship between RNA synthesis and aerobic metabolism in fundulus heteroclitus embryos.


Development of Xenopus laevis skin glands in organ culture.


Relationship between the density of plant cells and their growth kinetics in submerged medium.


Synchronization of HeLa cells by vinblastine sulfate.


The mathematical treatment of growth curves of malignant mammalian cells cultured in vitro.


Determination of thymidine metabolism in HeLa cell cultures by a combined electrophoretic and paper chromatographic method.


Regeneration of yeast protoplasts in agar gels.


Surface potential errors introduced by the truncation of the infinite series that represents an eccentric dipole.


A novel cardiotachometer.

A novel cardiotachometer.


Difference in the frequency of sex chromatin positive cells in the different intermitotic phases of human cells in tissue culture.


Measurement of respiration rate from central venous pressure in the critically ill patient.


Oscillatory behavior of respiratory gas exchange in resting man.


Criteria of viability in heat-treated cells.


Microperforation with laser beam in the preparation of microelectrodes.


Rubimedin particles on chloroplast lamellae.


On the determination of an optimum microwave diathermy frequency for a direct contact applicator.


Determining surface potentials from current dipoles, with application to electrocardiography.


A regulated differential fluorometer for the assay of oxidative metabolism in intact tissues.


The diagnostic problem of the Stein-Leventhal syndrome. A review of the literature and report on 9 cases.


The localization of fluorescent insulin in mouse tissues.


Synthesis of G1 protein preceding DNA synthesis in cultured mammalian cells.


Adaptation of mammalian cells to cold. IV. Diploid cells.


An inexpensive method of automatically presenting patterned and unpatterned monochromatic light.


The effects of a pre-time-out stimulus on matching-to-sample of humans. In each of two experiments human subjects were intermittently reinforced with money on a fixed-ratio schedule for emitting correct matching responses. A pre-time-out stimulus which signaled removal of positive reinforcement was periodically superimposed. In the first experiment the superimposed pre-time-out stimulus was paired with a 1-min or 4-min response-independent time out. In the second experiment the pre-time-out stimulus was paired with a 1-min or 4-min time out contingent on the incorrect responses. The pre-time-out stimulus did not markedly influence performance when the time out was response independent. In contrast, the pre-time-out stimulus markedly suppressed incorrect responding when the time out was contingent on the incorrect responses. When duration of this time-out was increased from 1-min to 4-min, suppression of incorrect responding increased and correct responding was suppressed. Therefore, behavioral suppression by a pre-time-out stimulus was obtained only when the signaled aversive event-time out-was response produced. In this case, suppression was influenced by time-out duration.


Autoradiographic study of DNA-synthesis in the regenerating liver of the mouse.


Orientation of Euglena by radio-frequency fields.


Intracellular distribution of histone-like proteins in Tetrahymena pyriformis.


Giant cell adenocarcinoma of the lung.

Giant cell adenocarcinoma of the lung.


Modern concepts in cancer of the colon and rectum.


Breast cancer treated at the Johns Hopkins Hospital, 1951-1956. Review of international ten-year survival rates.


Morphologic changes induced in the lungs of hamsters and rats by external radiation (x-rays). A study in experimental carcinogenesis.


Disseminated histiocytosis associated with atypical lymphoid cells (lymphohistiocytosis).


Mesenchymal tumors of the uterus. 3. A clinical and pathologic study of 31 carcinosarcomas.


Anatomic distribution and grading of carcinoma in situ of the cervix.


Effect of thiazide preparations on the pancreas.


Intestinal obstruction and mucoviscidosis.


Electrophoresis of lactate dehydrogenase, alkaline phosphatase and non-specific esterase in jejunal biopsies of controls and patients with malabsorption syndrome.


Some queries in connection with excision of the eye for melanoblastoma.


Some observations on the treatment of premature retinopathy with variable oxygen tension.


Congenital ocular melanosis, conjunctival naevus, conjunctival melanosis, conjunctival melanoma.


Juvenile lipidosis.

Juvenile lipidosis.


Chemical aspects of the juvenile forms of lipidosis.


Development and mode of action of the rhodopsin system in the photoreceptor cell.


Clinical demonstrations.

Clinical demonstrations.


The rectal biopsy as a diagnostic aid in atrophia retinae as part of a systemic disease.


The diagnosis of tumours in the region of the optic chiasma.


Ocular pemphigus.

Ocular pemphigus.


Developmental histochemistry of the autonomic ground plexus.


Pathological changes in abdominal sympathetic ganglia of animals with fulminating experimental diarrhea.


Further studies on electromyographic findings in generalized scleroderma.


Closed abdominal injuries in children.

Closed abdominal injuries in children.


Electric skin test of the spinal area in juvenile rheumatoid  arthritis.


Experimental funnel chest (pectus excavatum).


Chemical studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins.


Intralobar pulmonary sequestration: aortographic demonstration.


Spectrographic analysis of cries from children with maladie du cri du chat.


Bronchopulmonary lavage. New techniques and observations.


Morbidity and mortality due to cancer of the lung in 1200 in-patients with pulmonary disorders; a follow-up study.


Comparative evaluation of blood levels and tolerance of sodium PAS and conjugated PAS and ascorbic acid.


Chest contour (structure) and cardiovascular work.


High kilovoltage oblique roentgenography of the chest: its advantage in differential diagnosis in diseases of the lung and the pleura.


Pulomonary edema in the course of a blood transfusion without overloading the circulation.


C-reactive protein in pulmonary tuberculosis.


Effect of ultrasonic nebulized suspensions on pulmonary surfactant.


Veno-arterial pulsatile partial bypass for circulatory assist.


Bernheim effect (produced by an interventricular septal aneurysm following septal infarction).


Roentgenogram of the month.

Roentgenogram of the month.


Malignant thymoma with myasthenia and embolic metastasis; report of a case.


Aorto-pulmonary fistula; report of a case.


The ectopic tracheal bronchus: management of a child by excision and segmental pulmonary resection.


Preliminary communication of the effect of Gastrin II on acid secretion in conscious rats with chronic gastric fistula.


Cytokinetics of antibody formation.

Cytokinetics of antibody formation.


Histologic changes in the locally irradiated spleen related to the immune response.


Cytokinetics and regulation of progenitor cells.


The role of the thymus in the ontogeny of the immune system.


Ontogenesis of erythrocytes and hemoglobin formation.


Growth and senescence of antibody-forming cells.


Tertiary structure of sickle cell hemoglobin and its functional significance.


Phylogenetic variation in the primary structure of hemoglobins.


Primary structure of immunoglobulins and its relationship to antibody specificity.


Genetic regulation of peptide synthesis in hemoglobins.


Genetic regulation of immunoglobulin synthesis.


Electron microscopic studies of the alveolar lining film in fetal lungs.


Serum lipoprotein pattern in the nephrotic syndrome.


Serum complement level in renal diseases.


Radioisotope renocystography in various renal diseases.


Evaluation of renal function in ureterolithiasis and nephrolithiasis on the basis of radioactive renography.


Urinary osmolarity under hydropenic conditions in subjects presenting no clinical symptoms of renal function disturbance.


Detection of platelet antibodies by the complement fixation test.


Alimentary chylomicronemia in peptic ulcer and after partial gastrectomy.


Urinary excretion of 5-hydroxylindolacetic acid in patients with gastric and duodenal ulcer.


An analysis of 1000 cases of diabetes observed in Department 3 of Internal Diseases, Medical Academy, Warsaw, in the years 1954 through 1964.


The capillary resistance test in detection of vascular changes in diabetic patients.


Indications for albumin treatment in chronic cardiac insufficiency.


Incomplete antibodies in the course of brucellosis.


Activity of leukocyte alkaline phosphatase in some internal diseases.


Studies on the level of properdin and complement in the course of neoplasm in children.


The value of the DPA-reaction in the evaluation of the dynamics of rheumatic fever.


The levels of total, esterified and free cholesterol during labor and in early stage of puerperium. The relationship of these levels in the umbilical blood to the levels in the maternal blood in pregnancy.


Non-tuberculous "sterile" cavities in pneumoconiosis with massive tumor-like lung opacities in coal miners.


Further studies on the causes of failure of roentgenotherapy in carcinoma of the larynx.


Comparative investigations on the diagnostic value of purified tuberculins.


Determination of para-amino-salicylic acid in the saliva as check-up of treatment with this drug.


Measurement of the inhibitor of plasminogen activation in the euglobulin test.


The influence of calcium ions on the contractility of the isolated rat uterus in dependence on the extracellular fluid sodium concentrations.


Effect of smoking on cutaneous blood supply as determined by the measurement of heat conductivity coefficient.


Reduced glutathione of erythrocytes in acute experimental manganese poisoning.


Electrocautery of Bowman's membrane.

Electrocautery of Bowman's membrane.


Macular changes secondary to vitreous traction.


The ERG in amblyopia.

The ERG in amblyopia.


Krukenberg's spindles and primary open-angle glaucoma.


Chloroquine retinopathy: evaluation by fluorescein fundus angiography.


Fluorescein studies of patients with macular edema and papilledema following cataract extraction.


Ocular changes in myotonic dystrophy.

Ocular changes in myotonic dystrophy.


Brain scanning in neuro-ophthalmologic diagnosis.


Uveitis and joint diseases: a review of 191 cases.


A four-mirror gonioscope.

A four-mirror gonioscope.


Congenital cataract surgery.

Congenital cataract surgery.


A surgical gonioscope.

A surgical gonioscope.


Modified Westcott scissors with stop screw for enlarging cataract incisions in keratome-scissors technique.


Modified Castroviejo corneal scissors with stop screw for enlarging cataract incisions in keratome-scissors technique.


A vitreous aspirator controlled for 0.25 cc.


A four-mirror fundus biomicroscopy lens.


The status of presumed ocular histoplasmosis: including a report of a survey.


Roentgen therapy of epithelial invasion of the anterior chamber.


The effect of electrical anesthesia on intraocular pressure.


Bilateral retinal detachment and degenerations.


The temperature-reversible cation shift of the lens.


Changes in lens epithelium after x-ray or neutron irradiation (mouse and rabbit).


Descemet's membrane tubes.

Descemet's membrane tubes.


Retinal arteriolosclerosis in age, essential hypertension, and diabetes mellitus.


Chronic psychiatric hospital patients.

Chronic psychiatric hospital patients.


Mortality of psychiatric patients.

Mortality of psychiatric patients.


Family relationship variables in schizophrenia.


Genetics of neurotic depression.

Genetics of neurotic depression.


Psychophysiological reactions of a rural and suburban population in Taiwan.


Neuro-psychiatric syndromes associated with human trypanosomiasis in tropical Africa.


The intracellular cysteine-cystine ratio in kidney cortex.


Phosphatidylglycerylglucosamine.

Phosphatidylglycerylglucosamine.


The morphological origin and function of the polysomes isolated from rat liver.


The control of glycolysis and gluconeogenesis in kidney cortex.


Oestrogen biosynthesis in vitro by adrenal tissue from the golden hamster.


The 'permissive' effect of hydrocortisone on the induction of delta-aminolaevulate synthetase.


A specific requirement for biotin in the synthesis of ornithine carbamoyltransferase by yeast. 1. Growth of a biotin-requiring strain of Saccharomyces cerevisiae in a medium containing a suboptimum concentration of biotin for growth caused a decreased synthesis of ornithine carbamoyltransferase as compared with yeast grown in a medium containing an optimum concentration of biotin. Inclusion of the biotin homologues norbiotin or homobiotin, but not bishomobiotin, in the biotin-deficient medium caused an appreciable increase in ornithine carbamoyltransferase synthesis without affecting growth or synthesis of total RNA and protein. The addition of norbiotin to biotin-deficient medium had no effect on the respiratory activity of the yeast or on the synthesis of aspartate carbamoyltransferase, acid phosphatase, beta-fructofuranosidase or malate dehydrogenase. 2. Synthesis of acetylornithine deacetylase and acetylornithine acetyltransferase was slightly diminished by the imposition of biotin deficiency, but the effect was not as great as on ornithine carbamoyltransferase synthesis. Incorporation of norbiotin in the biotin-deficient medium had no marked effect on the synthesis of any other arginine-pathway enzyme except ornithine carbamoyltransferase. 3. l-Ornithine induced synthesis of ornithine carbamoyltransferase in yeast grown in biotin-deficient medium, but in yeast grown in this medium supplemented with norbiotin it repressed synthesis of the enzyme. l-Arginine had no detectable effect on ornithine carbamoyltransferase synthesis by the yeast grown in biotin-deficient medium with or without norbiotin. l-Aspartate repressed synthesis of ornithine carbamoyltransferase in biotin-deficient yeast and completely nullified the stimulatory effect of norbiotin on synthesis of the enzyme in this yeast. 4. There was no increase in ornithine carbamoyltransferase synthesis in biotin-deficient yeast incubated in phosphate buffer, pH4.5, containing glucose and biotin or norbiotin. In biotin-deficient yeast suspended in complete medium containing an optimum concentration of biotin, there was an increase in ornithine carbamoyltransferase synthesis only after the onset of growth.


The synthesis of noradrenaline by isolated guinea-pig atria. 1. The initial rate of formation of noradrenaline by isolated atria from a physiological concentration of tyrosine was measured. 2. Study of the time-course of the formation led to the conclusion that newly formed noradrenaline enters a fraction of the total pool. Synthesis and turnover was maintained for at least 1.5hr. In this time it was not possible to increase the concentration in the storage pool by employing high concentrations of precursor. 3. Preincubation of the tissue with noradrenaline resulted in an accumulation within the tissue and inhibited new formation. It is suggested that this indicates the existence of a physiological mechanism to limit the synthesis of noradrenaline, avoid saturation of storage sites and enable the ;re-uptake' process to operate. 4. The amount of noradrenaline formed from 3-hydroxytyramine (dopamine) was considerably greater than from tyrosine. The kinetic constants of the reactions are in agreement with the view that hydroxylation of tyrosine to dihydroxyphenylalanine (dopa) is rate-limiting.


The synthesis of o-aminophenyl glucuronide in several tissues of the domestic fowl, Gallus gallus, during development. 1. Synthesis of o-aminophenyl glucuronide has been studied in tissues of the domestic fowl, Gallus gallus, during development. 2. The only route of synthesis detected is glucuronyl transfer from UDP-glucuronic acid, and evidence suggests this to be the major pathway. 3. The pathway exists in liver, to a lesser extent in kidney and alimentary tract, and possibly also in skin. It is absent from spleen and adrenal gland. 4. o-Aminophenyl glucuronide formation, UDP-glucuronyltransferase, UDP-glucuronic acid and UDP-glucose dehydrogenase exist in the embryo liver from at least 12 days of incubation. Transferase activity falls just before hatching and rises suddenly on emergence. Overall synthesis of o-aminophenyl glucuronide observed in liver slices confirms this pattern, which also occurs in kidney. UDP-glucuronyltransferase appears in intestinal mucosa only after hatching, and is absent from embryonic spleen. The allantoic membrane forms no o-aminophenyl glucuronide. 5. These findings are related to the isolated existence of an avian embryo.


The pectic enzymes of Aspergillus niger. A mercury-activated exopolygalacturonase. 1. An exopolygalacturonase was separated from a mycelial extract of Aspergillus niger with a 290-fold purification and a recovery of 8.6%. 2. The enzyme displayed its full activity only in the presence of Hg(2+) ions; K(A) for mercuric chloride was about 6x10(-8)m. 3. The mercury-activated enzyme progressively removed the terminal galacturonic acid residues from alpha-(1-->4)-linked galacturonide chains and converted digalacturonic acid, trigalacturonic acid, tetragalacturonic acid and pectic acid into galacturonic acid.


Ribonucleic acid synthesis in yeast. The effect of cycloheximide on the synthesis of ribonucleic acid in Saccharomyces carlsbergensis. 1. Cycloheximide causes the release of the control amino acids have over RNA synthesis in Saccharomyces carlsbergensis N.C.T.C. 74. 2. The antibiotic causes a gradual deceleration of RNA formation. After incubation for 60min. at 30 degrees RNA synthesis usually proceeds at a rate only a few per cent of that of the untreated control. 3. In the presence of cycloheximide two types of RNA accumulate in the cell: soluble RNA and a high-molecular-weight RNA. The latter has a base composition intermediate between those of yeast DNA and yeast ribosomal RNA, and sediments in a sucrose gradient at a rate faster than that of the 23s ribosomal RNA component. 4. Yeast ribosomal RNA contains methylated bases. Judged from the incorporation of [Me-(14)C]methionine, the extent of methylation of ribosomal RNA is about 20% of that of the ;soluble' RNA fraction. The high-molecular-weight RNA formed in the presence of cycloheximide is less methylated than normal RNA. In this case the sucrose-density-gradient sedimentation patterns of newly methylated and newly synthesized RNA do not coincide. 5. In the presence of cycloheximide, polysomal material accumulates, indicating that messenger RNA is formed. 6. The effect of the antibiotic on protein and RNA synthesis can be abolished by washing of the cells. The RNA that has accumulated during incubation of the cells with the antibiotic is not stable on removal of cycloheximide. 7. The results presented in this study are discussed in relation to the regulation of RNA formation in yeast.


Studies on sea-snake venoms. Crystallization of erabutoxins a and b from Laticauda semifasciata venom. 1. The toxic principles in the venom of the sea-snake Laticauda semifasciata were separated into two components by CM-cellulose chromatography and obtained in crystalline forms. They were named ;erabutoxins a and b'. 2. The homogeneity of each toxin was shown by rechromatography, by disk electrophoresis, by ultracentrifuging, by toxicity measurements before and after repeated crystallizations and by N-terminal analysis. 3. They had molecular weights of about 7000. Both of them contained 61 (or 62) amino acid residues/molecule. The only difference between erabutoxins a and b was that one of the aspartic acid (or asparagine) residues in erabutoxin a was replaced by a histidine residue in erabutoxin b. 4. Both of the toxins had LD(50) values of 0.15mug./g. body wt. for mice and 0.07mug./g. for rats. It was shown with frog-muscle preparations that they acted on postsynaptic membrane to block neuromuscular transmission.


The uptake of lipids by rat liver cells. 1. Unesterified cholesterol, cholesterol esters and triglycerides of chylomicrons were taken up at the same rate by isolated hepatic parenchymal cells. 2. On incubation of hepatic cells, isolated 2min. after the injection of chylomicrons in vivo, the chylomicron triglyceride associated with the cells underwent hydrolysis. 3. In cells isolated 5min. after the injection of chylomicrons, the chylomicron triglyceride bound to the hepatic cells was accessible to added clearing factor lipase. 4. ;Ghost' hepatic cells had the same binding capacity and lipolytic activity per cell as intact cells. 5. Of all subcellular fractions studied, the ;plasma membrane' fraction showed the greatest capacity per unit weight for non-esterified fatty acid and chylomicron triglyceride binding and for triglyceride hydrolysis. 6. Once non-esterified fatty acids entered the hepatic cell, they were apparently metabolized in the same manner, whether taken up from the circulation as such or derived from chylomicron triglyceride.


Clearing-factor lipase in adipose tissue. A medium in which the enzyme activity of tissue from starved rats increases in vitro. 1. When epididymal fat bodies from starved rats are incubated for 3.5hr. at 37 degrees in a defined medium in vitro the total clearing-factor lipase activity rises to approximately twice its initial value. 2. During the incubation period part of the tissue clearing-factor lipase activity appears in the medium. 3. Heparin, glucose, insulin, and HCO(3) (-) and K(+) ions are shown to be important medium constituents.


Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release. 1. Acid phosphatase, cathepsin and beta-glucuronidase are released from rat-liver lysosomes by irradiation in vitro. Enzyme release is detectable after a dose of 1krad and increases with dose up to 100krads. 2. Maximum radiation effects were observed when the lysosomes were kept for 20hr. at 4 degrees or 20 degrees after irradiation. 3. An atmosphere of nitrogen considerably decreases enzyme release from lysosomes. 4. Enzyme release is enhanced by ascorbic acid and decreased by vitamin E. 5. Irradiation causes formation of lipid peroxides in lysosomes, and enzyme release increases with lipid peroxide formation. 6. It is suggested that lipid peroxide formation leads to rupture of the lysosome membrane and allows release of the contained hydrolytic enzymes.


The metabolism of radium in dairy cows.

The metabolism of radium in dairy cows. 1. The isotopes (45)Ca and (224)Ra were administered simultaneously, both orally and intravenously, to two pairs of cows. 2. The first pair of animals received large doses of (224)Ra and (45)Ca, which produced clinical and metabolic disturbances. 3. The second pair of animals received much smaller doses and showed no clinical disturbances. The mean recoveries in these animals of (45)Ca and (224)Ra in the 8 days after the oral administration were respectively: from faeces, 63.2 and 103.8%; from urine, 0.26 and 0.44%; from milk, 15.8 and 0.35% of the dose; and in the 8 days after intravenous administration: from faeces, 20.5 and 36.5%; from urine, 1.56 and 17.6%; from milk, 49.3 and 11.8% of the dose. 4. Calculation of discrimination factors shows that absorptive discrimination played the most important part in the overall discrimination between the calcium and radium in their passage from diet to milk, but that mammary discrimination plays a more important role than in the overall discrimination between calcium and strontium or barium. 5. In its treatment by the kidney radium is more like strontium than barium, but radium is actively secreted by the gut in the same way as barium. 6. In its skeletal metabolism radium is indistinguishable from calcium and strontium except in its rate of resorption, which is similar to that of barium.


Mechanisms of lipid peroxide formation in animal tissues. 1. Homogenates of rat liver, spleen, heart and kidney form lipid peroxides when incubated in vitro and actively catalyse peroxide formation in emulsions of linoleic acid or linolenic acid. 2. In liver, catalytic activity is distributed throughout the nuclear, mitochondrial and microsomal fractions and is present in the 100000g supernatant. Activity is weak in the nuclear fraction. 3. Dilute (0.5%, w/v) homogenates catalyse peroxidation over the range pH5.0-8.0 but concentrated (5%, w/v) homogenates inhibit peroxidation and destroy peroxide if the solution is more alkaline than pH7.0. 4. Ascorbic acid increases the rate of peroxidation of unsaturated fatty acids catalysed by whole homogenates of liver, heart, kidney and spleen at pH6.0 but not at pH7.4. 5. Catalysis of peroxidation of unsaturated fatty acids by the mitochondrial and microsomal fractions of liver is inhibited by ascorbic acid at pH7.4 but the activity of the supernatant fraction is enhanced. 6. Inorganic iron or ferritin are active catalysts in the presence of ascorbic acid. 7. Lipid peroxide formation in linoleic acid or linolenic acid emulsions catalysed by tissue homogenates is partially inhibited by EDTA but stimulated by o-phenanthroline. 8. Cysteine or glutathione (1mm) inhibits peroxide formation catalysed by whole homogenates, mitochondria or haemoprotein. Inhibition increases with increase of pH.


Protoplast formation and yeast cell-wall structure. The action of the enzymes of the snail, Helix pomatia. 1. The digestive juice of the snail Helix pomatia was used in the study of the degradation of isolated cell-wall preparations from a strain of Saccharomyces carlsbergensis. 2. The crude enzyme system was fractionated by gel filtration and the activities of the more specific fractions thus obtained were examined. 3. Results are discussed with respect to (a) the nature of various factors that are essential for protoplast formation and cell-wall dissolution and (b) structures envisaged in yeast cell walls that are responsible for the observed variations in susceptibility to attack by snail juice.


The metabolism of cis- and trans-indane-1,2-diol. 1. The metabolism of cis-indane-1,2-diol, trans-indane-1,2-diol, indene epoxide and 2-hydroxyindan-1-one in rats has been studied. The substances were administered to the animals by subcutaneous injection. 2. The urine of the dosed animals was examined for the presence of free and conjugated cis- and trans-dihydrodiols, and for each compound it was possible to isolate both cis and trans forms of indane-1,2-diol from the urine. 3. The urines were also examined by paper chromatography for ketones and two ketonic metabolites were detected in the urine of rats dosed separately with cis-indane-1,2-diol, trans-indane-1,2-diol, 2-hydroxyindan-1-one and indene epoxide. The ketones were provisionally identified as (1-oxoindan-2-yl glucosid)uronic acid and 1-oxoindan-2-yl sulphuric acid. 4. (1-Oxoindan-2-yl glucosid)uronic acid was isolated as the 2,4-dinitrophenylhydrazone from the urine of rats dosed separately with cis-indane-1,2-diol and trans-indane-1,2-diol. 5. Possible mechanisms for the interconversion of cis- and trans-indane-1,2-diol are discussed.


Inhibitory effect of salicylate on the incorporation of L-(U-14C)leucine into the protein of rat tissue preparations in vitro. 1. The inhibitory effect of salicylate, in concentrations ranging from 0.1 to 20mm, on the incorporation of radioactivity from l-[U-(14)C]leucine into the protein of isolated rat diaphragm muscle and of cell-free systems from rat liver was studied. 2. The lowest salicylate concentrations producing significant inhibitions of amino acid incorporation were as follows: isolated rat diaphragm, 0.1mm; rat-liver mitochondrial-microsomal system, 0.1mm; rat-liver microsomal system, 0.3mm. 3. Salicylate concentrations of 2.5mm and above were found to inhibit creatine-kinase activity in vitro.


A method for the estimation of urinary testosterone. 1. A method has been developed for the estimation of testosterone in human urine by using acid hydrolysis followed by a quantitative form of a modified Girard reaction that separates a ;conjugated-ketone' fraction from a urine extract; this is followed by column chromatography on alumina and paper chromatography. 2. Comparison of methods of estimation of testosterone in the final fraction shows that estimation by gas-liquid chromatography is more reproducible than by colorimetric methods applied to the same eluates from the paper chromatogram. 3. The mean recovery of testosterone by gas-liquid chromatography is 79.5%, and this method appears to be specific for testosterone. 4. The procedure is relatively rapid. Six determinations can be performed by one worker in 2 days. 5. Results of determinations on human urine are briefly presented. In general, they are similar to earlier estimates, but the maximal values are lower.


The stereospecific biosynthesis of plant sterols and alpha- and beta-amyrin. 1. A preparation of pea seedlings has been obtained that will incorporate [2-(14)C]mevalonate into squalene, alpha- and beta-amyrin and the phytosterols. 2. The (14)C/(3)H ratio in alpha- and beta-amyrin biosynthesized in the presence of [2-(14)C,4R-(3)H]-mevalonate is the same as in the starting material and in squalene; this gives experimental support to the mechanism for the cyclization of squalene proposed by Ruzicka for the formation of these pentacyclic triterpenoids. 3. The (14)C/(3)H ratio for beta-sitosterol was 5:3, the same as that in cholesterol in liver. 4. As the absence of (3)H from C-3 in beta-sitosterol was demonstrated (3)H must be present in the side chain and thus the H at C-24 is not lost during alkylation of the side chain; it probably migrates to C-25.


The biosynthesis of sterols in higher plants. 1. [2-(14)C]Mevalonate was incorporated into squalene and the major phytosterols of pea and maize leaves; it was also incorporated into compounds belonging to the 4,4-dimethyl and 4alpha-methyl steroid groups and which may be possible phytosterol intermediates. 2. l-[Me-(14)C]Methionine was incorporated into the major sterols and also into the 4,4-dimethyl and 4alpha-methyl steroid groups. No radioactivity was detected in squalene. 3. Under anaerobic conditions incorporation of [2-(14)C]-mevalonate into the non-saponifiable lipid of pea leaves was drastically decreased but radioactive squalene was accumulated. 4. Cycloartenol, 24-methylenecycloartanol, 24-methylenelophenol, 24-ethylidenelophenol, fucosterol, beta-sitosterol, stigmasterol and campesterol have been identified by gas-liquid chromatography in pea leaves. 5. The significance of these results in connexion with phytosterol biosynthesis and the introduction of the alkyl group at C-24 into phytosterols is discussed.


Transport and metabolism of thiamine in Ehrlich ascites-carcinoma cells. 1. Aerobic or anaerobic incubation at 37 degrees of Ehrlich ascites-carcinoma cells in Krebs-Ringer bicarbonate medium containing glucose and labelled thiamine results in accumulation in the cell of labelled thiamine, so that the concentration of total labelled thiamine in the cells greatly exceeds (by a factor 7) that in the medium. This concentration ratio is approximately constant for small initial external concentrations of labelled thiamine but diminishes when the latter exceed 0.4mum. 2. All the labelled thiamine in the tumour cells is present as thiamine phosphates. 3. The uptake of labelled thiamine is markedly diminished by decrease of temperature. At 9 degrees concentration ratio (cells/medium) 0.5 is observed whereas at 37 degrees the concentration ratio is 8.6. 4. The extent of phosphorylation of labelled thiamine depends on the period of incubation. 5. The influx of labelled thiamine is diminished by the presence of its analogues, pyrithiamine and Amprol, and also by the presence of thiamine monophosphate and thiamine diphosphate, which are potent inhibitors of thiamine phosphorylation in Ehrlich ascites cells. 6. Labelled thiamine phosphates leak from the cell into the medium, so that eventually all the labelled thiamine, both in the cell and medium, is converted into thiamine phosphates. However, in the presence of 2,4-dinitrophenol (0.1mm) and iodoacetate (1mm) thiamine phosphorylation is diminished, the concentration ratio for labelled thiamine (cells/medium) falls to half its normal value and little or no labelled thiamine phosphates leaks into the medium. 7. In the presence of thiamine phosphates, free labelled thiamine accumulates in Ehrlich ascites cells against a concentration gradient, concentration ratios (cells/medium) greater than unity being evident. 8. The evidence supports the conclusion that thiamine is transferred into the Ehrlich ascites cell by a carrier-mediated energy-assisted process.


The indirect analysis of 17-oxosteroid glucosiduronates and sulphates in human urine. 1. An analytical procedure has been developed for the determination of urinary 17-oxosteroid sulphates and 11-deoxy-17-oxosteroid glucosiduronates. 2. By submitting urine to the following operations: (a) extraction of the 17-oxosteroid conjugates into chloroform (in the presence of pyridinium sulphate), (b) solvolysis (in the absence of acid) of the steroid sulphates, (c) separation of the steroid glucosiduronates, (d) hydrolysis of the glucosiduronates, (e) oxidation with tert.-butyl chromate of the liberated steroids and (f) analysis of the final extracts by gas-liquid chromatography, the 17-oxosteroid conjugates are converted into and measured as androstanediones and androstane-(ene)triones. 3. Values for the daily excretion of 17-oxosteroid glucosiduronates and sulphates in normal men and women are given.


Effect of ethionine treatment on the activity of enzymes concerned with urea synthesis in rat liver. 1. The activities of the enzymes of the urea cycle were measured in rat liver after feeding with a diet containing ethionine for 2 weeks. This treatment resulted in a decrease in the activity of ornithine transcarbamoylase, which fell to half the control value, while arginase increased by about 40%. The remaining enzymes of the urea cycle were unchanged at this time of treatment. These results are discussed in relation to the known effects of ethionine on nucleic acid synthesis. 2. The activities of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were measured in rat liver after feeding with a diet containing ethionine for 2 or 5 weeks. At the shorter time-period glucose 6-phosphate-dehydrogenase activity was more than doubled but 6-phosphogluconate-dehydrogenase activity remained unchanged. 3. The results are compared with similar measurements made after feeding with diets containing 4-dimethylamino-3'-methylazobenzene for 2 weeks. Striking similarities were found in the pattern of change in the enzyme activities of each of the pathways in the two treatments.


Acetylene reduction by nitrogen-fixing preparations from Clostridium pasteurianum.


Formate utilization by Nitrobacter winogradskyi.


Aromatic biosynthesis in yeast. I. The synthesis of tryptophan and the regulation of this pathway.


Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. I. Evidence for a specific arginine-transporting system.


Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. II. Evidence for a specific lysine-transporting system.


Casein biosynthesis: evidence for phosphorylation of precursor proteins.


Stimulation of [14C]glucosamine incorporation into plasma proteins by aminonucleoside.


Isolation and characterization of induced ceruloplasmin from chicken serum.


The molecular structure of human ceruloplasmin: evidence for subunits.


The amino acid sequence of the delta-beta chains of hemoglobin Lepore Augusta = Lepore Washington.


Combining sites of antibodies with L-alanine and D-alanine peptide specificity and the effect of serum proteolytic activity on their estimation.


Isolation of the B and C chains from S-sulfonated alpha-chymotrypsin.


Purification of a neurotoxin from the venom of Naja nigricollis.


The effect of polyhydric alcohols on the determination of inorganic phosphorus.


Intramitochondrial uptake of 32P in adenine nucleotides in congestive heart failure.


High lysozyme concentration and lysis of Micrococcus lysodeikticus.


Comparative study of metal-free, iron-saturated and sialic acid-free transferrins.


Extending the range of application of the Edman method. Application to short peptides in small amounts.


A method for identifying C-terminal amino acids as their DNS-derivatives obtained after the hydrazinolysis of peptides.


Studies on peptides. XI. The effect on melanotropic activity of altering the arginyl residue in L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycine.


Dissociation of hemoglobin from different animal species into subunits.


The hexose content of the alpha chains of codfish skin collagen.


Weight-lifting and adrenal cortex function in man.


Macroglossia.

Macroglossia.


Venereal infection in elderly people.

Venereal infection in elderly people.


The serum vitamin B-12 in the elderly.

The serum vitamin B-12 in the elderly.


Anaemia in patients in a psychiatric hospital.


Undiagnosed myocaridal infarction in the aged.


Rehabilitation as a function of nursing.


Extramural evaluation of medical education.


Enzymic activities in meconium from human foetuses and newborns.


Fetal development of nonspecific esterases and alkaline phosphatases activities in the small intestine of the man.


Thermal requirements of undergrown human neonates.


The rate of disappearance of erythrocytes containing Heinz bodies in premature subjects.


Alveolar lining film of the lungs in newborn infants with hyaline membrane disease.


The expression of maternally-transmitted sex ratio condition (SR) in two strains of Drosophila melanogaster.


Correlation of histocompatibility and biologically active serum factors between parental and filial generations of Wistar rats inoculated with Walker Carcinoma 256.


Electrophoretic pattern of serum proteins and lipids in leukaemias.


Comparative study between stools, rectal swab, rectal scraping, rectal biopsy and liver biopsy examination methods in the diagnosis of 96 bilharzial hepatosplenomegalic.


Index of platelet adhesiveness in rheumatic valvular disease.


Studies with insulin -I-131 in insulin resistant diabetes.


Hyposensitization therapy in asthmatic children.


The role of bilharziasis in stone formation in Egypt.


The effect of therapeutic doses of carbon tetrachloride on liver and kidney functions in sheep.


Probability and payoff as factors influencing two-choice reaction-time.


Readability and operability of three types of digital switches.


Application of Corbusier's human-scale to the layout of work space for typewriting.


Newcastle disease virus RNA. I. Isolation and preliminary characterization of RNA from virus particles.


The crystal structure of a purine-pyrimidine hydrogen-bonded complex: 9-ethyl-2-aminopurine and 1-methyl-5-fluorouracil.


Newcastle disease virus RNA. II. Preferential synthesis of RNA complementary to parental viral RNA by chick embryo cells.


Electrophoretograms of soluble proteins of lens in different species.


Renaturation of T4 bacteriophage deoxyribonucleic acid in the presence of excess heterologous DNA.


Clinical trial on Brahmi. II. Psychological investigation with normals.


Peculiarities of the secondary structure of phage DNA in situ.


Studies on contraction kinetics of denervated skeletal muscle of toad.


Highly radioactive fallout particles ingested by mice.


The subunits of bovine liver glutamate dehydrogenase: demonstration of a single peptide chain.


Radiolysis of cystine in aqueous solution by gamma irradiation.


Seasonal variation of specific gravity of blood in Indian and western adults.


Recovery of the sequestrated plasma by nor-adrenaline in cooled dogs.


Radiation-induced decoloration of dyestuffs in aqueous solution.


A gamma-ray irradiation facility for biochemical research.


Environmental contamination with radioruthenium, 1961-1965.


Clinicopathologic conference. Headache and paresis. Résumé of a case.


The patient has the floor.

The patient has the floor.


Measurement of oxygen saturation in arterial and venous blood of bone in normal puppies and in puppies with arteriovenous fistula.


Experiences with a conditioned aversion type of treatment for alcoholism in a service setting.


Changes in the total blood serum cholesterol level, cardiovascular condition and adiposity of adult males following one season of ice hockey.


A prolonged dialysis.

A prolonged dialysis.


Salmonellosis.

Salmonellosis.


Salmonellosis in Canada--1965.

Salmonellosis in Canada--1965.


Effects of uremic sera on renal tubular P-aminohippurate transport.


Simplified hippuran clearance. Measurement of renal function in man with simplified hippuran clearances.


The localisation of cephaloridine and nitrofurantoin in the kidney.


Urine concentration after acute renal failure.


Phosphatide composition of normal, hyperplastic and malignant squamous epithelium.


The effect of preoperative roentgen therapy upon the tensile strength of rectosigmoid anastomoses in dogs.


Fine structure of the endothelial cells of blood sinusoids in the carotid body.


A study of the correlation between the amino acid composition and the helical content of proteins.