History of the Hebrew medical press of the I.M.A.


Fetal hemoglobin concentration in maternal and cord blood during fetal development and in disorders of pregnancy.


Experiences with natural childbirth.

Experiences with natural childbirth.


Early and late leishmanlasis.

Early and late leishmanlasis.


Neurologic and therapeutic notes on chorea; the value of the contralateral abdominal proprioceptive reflex.


The treatment of prolonged shock with 1-noradrenaline (levarterenol).


Vaginal endometriosis and sterility.

Vaginal endometriosis and sterility.


On the problem of depersonalisation; with case presentation.


Observations on the clinical effectiveness of certain metabolites in the treatment of delirium tremens; a preliminary report.


Cardiac wounds treated by pericardiotomy and cardiorrhaphy; a report of seven recent cases.


Rotational x-ray therapy with the use of a grid as a clinical method.


Temporomandibular dislocations; the use of muscle relaxing agents in the reduction of difficult cases:  a preliminary report.


The prognostic value of x-ray pelvimetry.


Revascularization operations for coronary artery disease.


Limitations of the pathologist in modern medicine.


The future of enzyme research.

The future of enzyme research.


Newer agents for the anesthesiologist.

Newer agents for the anesthesiologist.


Induced hypotension.

Induced hypotension.


Preparation of natural foods for tube feeding.


Myofascial pain syndromes.  II.  Syndromes of the head, neck and shoulder girdle.


Treatment of complete A-V heart block.

Treatment of complete A-V heart block.


Thirty years of clinical psychology.

Thirty years of clinical psychology.


THE SHOULDER-HAND syndrome.

THE SHOULDER-HAND syndrome.


Scalene lymph node biopsy.

Scalene lymph node biopsy.


An approach to the etiology, diagnosis and management of peripheral arteriosclerosis (arteriosclerosis obliterans).


SYMPOSIUM on postmastectomy lymphedema of the arm.


HYPERVENTILATION as a cause of cardiovascular symptoms.


Postmastectomy lymphedema of the arm:  historical review.


Goals for heart disease.

Goals for heart disease.


Lymphangiosarcoma occurring in postmastectomy lymphedema.


REPAIR of arterial injuries.

REPAIR of arterial injuries.


Postmastectomy edema of the arm:  roentgen aspects.


Physical factors in postmastectomy lymphedema.


Bilateral agenesis of upper extremity.

Bilateral agenesis of upper extremity.


Isotopes in medicine; introduction.

Isotopes in medicine; introduction.


Experience with intra-cavitary radio-gold at Henry Ford Hospital.


Acute miliary disease of the lung; diagnosis and treatment.


Central retinal vein occlusion treated with anticoagulant and steroid therapy:  case report and discussion.


Neurological disorders associated with hepatic diseases.


Myofascial pain syndromes.  III.  Some syndromes of the trunk and thigh.


Morning lift; early bird coffee service cheers patients.


The technique of soliciting.

The technique of soliciting.


How to seek foundation support.

How to seek foundation support.


The evaluation of hospital management.  III.


Standards amended for hospital accreditation.


Two innovations improve patient care.

Two innovations improve patient care.


Are your documents in order?

Are your documents in order?


Needed:  an inhalation therapy department for specialized treatment, efficient care, greater safety.


PRINCIPLES for better nursing care.

PRINCIPLES for better nursing care.


How central service grows.  I.

How central service grows.  I.


Salary and wage administration; position control simplifies budgeting and offers solution to staffing problems.  II.


A SURVEY of bread serving practices.  II.


Five years' experience with a high humidity room.


Say farewell to missing pharmacy charges.


Standardization of equipment; is it worthwhile?


Laboratory equipment.

Laboratory equipment.


Work injuries to hospital employees; a preliminary study by the Bureau of Labor Statistics.


Safety is everybody's business.

Safety is everybody's business.


Safety begins at the top.

Safety begins at the top.


Solving patient and visitor safety problems.


Our safety program paid a $45,000 dividend.


Spelling out a pattern for safety at the state level.


Spelling out a pattern for safety at the local level.


Medical staff appointments in public hospitals.  III.  Professional misconduct and rights of osteopathic physicians.


How to get off the housekeeper's treadmill.


We built in safety to insure a healthy safe working area for our food service employees.


A hospital store is only as good as its keeper.


Patient consultations.

Patient consultations.


We gained time and lost motion.

We gained time and lost motion.


HOSPITALS through the centuries.

HOSPITALS through the centuries.


How to handle property and depreciation records.


A rational basis for buying insurance.

A rational basis for buying insurance.


Teaching health to the community.

Teaching health to the community.


Color therapy for environmental monotony in chronic disease hospitals.


Six tests of purchasing effectiveness.

Six tests of purchasing effectiveness.


Children will eat hospital food.

Children will eat hospital food.


Essay on a fundamental law of life; the time-factor (relativity) in biological phenomena.


The ABO blood groups and the sex ratio.

The ABO blood groups and the sex ratio.


Cranial allometry in the great apes.

Cranial allometry in the great apes.


Relation between hair color and metals in human hair.


Force analyses of horizontal two-handed pushes and pulls in the sagittal plane.


Injuries to the ureter.

Injuries to the ureter.


Recent advances in exfoliative cytology.


Hypothermia in surgery for major vascular graft.


Observations on the aging process.

Observations on the aging process.


Amebiasis and amebic dysentery.

Amebiasis and amebic dysentery.


Illinois physician-botanists.

Illinois physician-botanists.


The physiology of aging.

The physiology of aging.


Prenatal testicular infarction.

Prenatal testicular infarction.


Adenomatoid tumor of the epididymis.

Adenomatoid tumor of the epididymis.


The practice of medicine in an industrial society.


Safe handling of toxic materials by the pest control operator.


Management and scope of treatment in the surgical department of a large industry.


Medical aspects of automation; influence on industrial medical programs.


MAINTAINING emotional health:  Menninger Foundation Seminar for Industrial Physicians.


Psychiatric treatment; somatic methods.

Psychiatric treatment; somatic methods.


Rehabilitation of the emotionally ill.

Rehabilitation of the emotionally ill.


Psychiatric treatment; brief psychotherapy procedures for the industrial physician.


The traumatic abdomen.

The traumatic abdomen.


SPECIALTY certification through examination.


Emotional problems in convalescence.

Emotional problems in convalescence.


The effectiveness of periodical medical evaluation.


The early detection of disease by periodic examination.


The engineering of consent for an industrial medical program in the U. S.


Inter-personal communication.

Inter-personal communication.


Experience in communication and persuasion in the area of health.


Fundamental factors in persuasion.

Fundamental factors in persuasion.


Motivation in health education.

Motivation in health education.


Surgery of the biliary passages.

Surgery of the biliary passages.


The new look in occupational medicine.

The new look in occupational medicine.


Grease gun injury; a case report.

Grease gun injury; a case report.


Contact sensitivity to inappreciable exposures.


The new pharmacologic attack in psychiatry.


Meprobamate; its pharmacologic properties and clinical uses.


Chlorpromazine in general practice.

Chlorpromazine in general practice.


A chronological hand-list of Freud's works.


Use of the tranquilizing properties of reserpine; a review.


The use of azacyclonol and pipradrol in general practice.


The medico-pharmaceutical arts of La Celestina; a study of a fifteenth century Spanish sorceress and dealer in love.


The Schreber case.

The Schreber case.


Freud's repression concept; a survey and attempted clarification.


The inception of Totem and Taboo.

The inception of Totem and Taboo.


Hypertension:  with a review of clinical experiences with a Rauwolfia preparation.


Freud's writing on art.

Freud's writing on art.


The artificial uterus.

The artificial uterus.


The response of patients with uremic coma to adenosine-5-monophosphate.


Dream and vision; some remarks on Freud's Egyptian bird dream.


Clinical and pathogenic viewpoints on nonbacterial subacute endocarditis.


Contributions to the study of nerve and muscle interrelationship; studies in the pathologic physiology of poliomyelitis.


The practicing physician and the Food and Drug Administration.


A food manufacturer looks at the Food and Drug Administration.


The Food and Drug Administration prepares a case for court.


A representative of American labor looks at the Food and Drug Administration.


Leaders of the Food and Drug Administration.


Measurement of vitamin potency.

Measurement of vitamin potency.


A cosmetic manufacturer looks at the Food and Drug Administration.


Symposium on developmental disorders in children, their mechanism and management; introduction.


Congenital anomalies in the newborn infant; their early recognition in relation to prognosis.


Experimental production of congenital malformations.


Psychochemotherapy of mental deficiency in children.


Present-day concepts of cerebral palsy.

Present-day concepts of cerebral palsy.


Diagnostic determinants of orthodontic disorders in children.


Developmental eye disorders in children.


Surgical management of the undescended testicle.


Management of mongolism in childhood.

Management of mongolism in childhood.


The figure-ground syndrome in the brain-injured child.


The developmental nature of pachyonychia congenita; a twenty year study of a case.


A nutritional approach to growth failure in children; a preliminary report.


Preliminary study on the use of hydroxyzine in psychosomatic affections.


The way of the investigator.

The way of the investigator.


Pancreatitis following subtotal gastrectomy.


Water intake and urine output before and after pregnancy.


Gingivectomy.

Gingivectomy.


The simultaneous estimation of isonicotonic acid hydrazide and serum mucoprotein.


Mescaline:  apotheosis of the devil's root.


The national bill of mortality:  a changing pattern and its problems.


The adrenal gland in pregnancy.

The adrenal gland in pregnancy.


Acute porphyria.

Acute porphyria.


A case of acute porphryia.

A case of acute porphryia.


Observations on anaesthesia for thoracic surgery.


The employment of ex-patients in a sanatorium.


Studies on the classification of the genus Candida; thermostable and thermolabile antigens of the seven species of the genus Candida.


Experimental anticancer studies.  III.  On the influence of living hemolytic streptocci upon the invasion power of Ehrlich ascites carcinoma in mice.


Studies on the O antigen of Shigella flexneri type Mita, with special emphasis on the biologically active factor.


Infectious bronchitis of chickens in Japan.  I.  Epidemiological, clinical, and pathological studies and isolation of the causative virus in embryonated eggs.


The elimination of metabolic disturbances produced by the injection of S. typhi, S. paratyphi B, Sh. Flexneri and prevention of animals from death through the application of adenosinetriphosphate.


The third effect of polarizing electrodes on the strength-duration-curve of nerve.


A method for the measurement of rhodopsin in separated outersegments of rods.


On the mechanism of muscle contraction.  I.  On the relationship between actomyosin formation and temperature.


On the mechanism of muscle contraction.  III.  A consideration on "steady state" in muscular contraction.


On the mechanism of muscle contraction.  II.  A new interpretation of the relationship between the temperature and the ATP contraction of glycerinated muscle fiber.


Studies by ultracentrifuge and paper electrophoresis on the effects of heparin and heparinoid substance on the lipoproteins in the serum of cholesterol-fed rabbits.


Protein denaturation by ionizing radiation and role of oxygen.


On the coupling effect of alternating currents in nerve.


Studies on the galvanic skin response using the current-and potential method.


Time factor in excitability of the brain by the repetitive pulse stimulation.


On the sleep response induced electrically in cats.


Studies on a pyrogenic and a growth promoting substance in blood plasma of virus diseased animals.


Studies on iron-protein metabolism with radioiron (Fe-55 and Fe-59).


Effect of direct electric current on E.C.G.


Electro-myographic study of the abdominal muscles in pregnancy.


Further studies on cone substances.

Further studies on cone substances.


Crossed reflexes of limbs observed in healthy man.


Excitability changes in ventral root fibers during the course of the ventral root potential.


A note on the shape and size of the human eccrine sweat pore.


Thermal analysis of the blood catalase reaction inhibited by various poisonous sunstances.  I.  Cyanide and azide.


On the acceleration of blood catalase reaction with surface-active agents.


Microelectrode studies on sensory afferents in the posterior funiculus of cat.


An anniversary greeting.

An anniversary greeting.


Morton Prince:  sketch of his life work.

Morton Prince:  sketch of his life work.


Some characteristics of affiliation motivation.


Learning and two kinds of anxiety.

Learning and two kinds of anxiety.


Interpersonal trust as a factor in communication.


Schizophrenia and central nervous system pathology.


Attitudes as adjustments to stimulus, background, and residual factors.


Verbal satiation and personality.

Verbal satiation and personality.


Understanding and similarity in marriage.


Psychotherapist's anxiety level, self-insight, and psychotherapeutic competence.


The avoidance of threatening material in imaginative behavior.


Microgenesis and aphasia.

Microgenesis and aphasia.


Perceptual rigidity and closure as functions of anxiety.


Parent-child relations and father identification among adolescent boys.


Perceptual accuracy in schizophrenia, depression, and neurosis, and effects of amytal.


The relationship of hostility to authoritarianism.


Body-image boundaries and style of life.


Predictability of perceptual defense behavior.


Postdecision changes in the desirability of alternatives.


The measurement of overt aggression from fantasy.


Content-free speech as a source of information about the speaker.


Individual anxiety thresholds and their effect on intellectual performance.


Opposite speech in a schizophrenic patient.


The application of conditioning and learning techniques to the treatment of a psychiatric patient.


The comparability of positive and negative items in scales of ethnic prejudice.


External validation of a measure of conformity behavior.


The immunophysiology of serum sickness; alterations in the radiosodium space and serum electrolyte concentrations during the course of repeated injections of horse serum into rabbits.


Bacterial hypersensitivity.

Bacterial hypersensitivity.


Prednisone and prednisolone in the treatment of allergic diseases.


Liberation and depletion of histamine from human skin; effect of an antihistamine and hydrocortisone on the activity of the histamine liberator, compound 48/80.


Studies on ragweed pollen.  I.  Preliminary fractionation of ragweed pollen; characterization and allergenicity of the isolated fractions.


Study on passive cutaneous anaphylaxis with serum of allergic patients.


Stomatitis from allergy to acrylic denture.


REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.


Dental health care programs for children.


The impact of group health care programs on medical practice.


The Richmond-Woonsocket studies on dental care services for school children.


Dental health care programs for the handicapped child.


International Longshoremen's and Warehousemen's Union, Pacific Maritime Association Health and Welfare fund dental health care programs for children:  a progress report of the first year's activity.


SUMMARIES of discussion on preschool and school dental health programs.


Hartford's preschool dental program.

Hartford's preschool dental program.


Predictability of dental care needs of adults.


Surgical approach in periodon'tal treatment.


Mat gold foil with a veneer cohesive gold foil surface for class V restorations.


Jacket crown transfer.

Jacket crown transfer.


BUREAU of Economic Research and Statistics; survey of former Armed Forces dental officers.


COUNCIL on dental therapeutics; council classifies thermodent tooth paste in group D.


COUNCIL reports on penicillin V (phenoxymethyl penicillin).


ASSOCIATION testifies on four congressional bills during week of April 9.


Meat and future health needs.

Meat and future health needs.


New and improved plants for human use.

New and improved plants for human use.


Diabetes; overweight:  U. S. problems.

Diabetes; overweight:  U. S. problems.


Psycho-social correlates of obesity; failure of calorie collectors.


What the homemaker knows about nutrition.  IV.  Her food problems, shopping habits, and sources of information.


Nineteenth century leaders in infant feeding.


Taste testing frozen meat cooked before and after thawing.


The dietitian on the mental health team.


Haematemesis in the elderly.

Haematemesis in the elderly.


Osteoporosis:  diagnosis and treatment.

Osteoporosis:  diagnosis and treatment.


The patient with incurable cancer.

The patient with incurable cancer.


Hypertension.

Hypertension.


Role of inactivity in production of disease; hypokinetic disease.


Treatment of the geriatric patient in a mental hospital.


Acute abdominal emergencies in the aged.


Problems peculiar to surgery of the aged.


Treatment of Parkinson's disease in the aged.


Treatment of peptic ulcer in the aged with unrestricted diet.


Role of cytology in detection of carcinoma of cervix.


Diagnosis and treatment of cardiac pericarditis by pericardial biopsy.


Carcinoma of the esophagus; a palliative procedure with use of a plastic tube introduced through a cervical incision.


Closing mechanism of lower esophagus in man; radiological study of five hundred unselected patients.


Rupture of liver with fatal hemorrhage due to intrahepatic vascular disease; report of two cases.


Pyelonephritis masquerading as toxemia of pregnancy.


Effects of isonicotinic acid hydrazides on mental status of tuberculous patients.


Neurotoxic reactions resulting from chlorpromazine administration.


Organization of a fluid and electrolyte balance service.


Leukemia and pregnancy; a problem in transmission in man.


Pregnancy and diabetes; results of management without female sex hormone replacement therapy.


Epistaxis resulting from metastatic renal carcinoma.


Unique allergic response to sulfisoxazole gantrisin; report of a case.


Toxoplasmosis in man and swine; an investigation of the possible relationship.


MEDICOLEGAL applications of bloodgrouping tests.


NEW AND nonofficial remedies.

NEW AND nonofficial remedies.


TUBELESS gastric analysis.

TUBELESS gastric analysis.


Effective use of autopsy in medical education; its role in correlation and integration.


The medical social caseworker in private medical practice.


Recent sociologic trends in medical practice.


The social worker as a teacher in medicine; with special reference to the home visiting program at the Oklahoma University School of medicine.


Standard nomenclature coding of pathological diagnosis.


Alien interns and residents in the United States, 1955-1956.


Maximum benefit from thromboendarterectomy; treatment of common iliac artery occlusion, with three-year follow-up.


Brown-Séquard syndrome with bilateral elephantiasis in neurofibromatosis.


The six unities in medical research.

The six unities in medical research.


Current status of the drug therapy of epileptic seizures.


Serologic response of infants and preschool children to poliomyelitis vaccine.


MEDICAL licensure statistics for 1955; fifty-fourth annual presentation of licensure statistics by the Council on Medical Education and Hospitals of the American Medical Association.


The early management of myocardial infarction.


Toxic effects of ammonium chloride in cardiac, renal and hepatic disease.


A controlled study of cortisone therapy for headache after pneumoencephalography.


Bilateral stenosis of renal arteries and hypertension; treatment by arterial homografts.


Rauwolfia-ephedrine as a hypotensive-tranquilizer.


Prednisone and prednisolone in the treatment of systemic lupus erythematous.


Fatal heart attack and successful defibrillation; new concepts in coronary artery disease.


Prolonged hypotension with fatal termination after a phentolamine (regitine) methanesulfonate test.


Neuromuscular performance and sensory receptivity in a triple congenital amputee; report of a case.


Unusual electrocardiographic findings in cardiac amyloidosis.


Analysis of professional factors in medical malpractice claims.


Diagnostic problems:  presentation of case.


Infantile scurvy; the increasing incidence of scurvy in the Nashville area.


PHENOXYMETHYL penicillin.

PHENOXYMETHYL penicillin.


PROMETHAZINE hydrochloride.

PROMETHAZINE hydrochloride.


BETAZOLE Hydrochloride.

BETAZOLE Hydrochloride.


SODIUM glutamate.

SODIUM glutamate.


ADDITIONAL uses of methylbenzethonium chloride.


THE NEW N.N.R.

THE NEW N.N.R.


SEROTONIN.

SEROTONIN.


The heart of a child.

The heart of a child.


Studies on the etiology and treatment of acute renal failure.


Reversible uremic states.

Reversible uremic states.


Radioyttrium (Y90) for the palliative treatment of effusions due to malignancy.


Cancer of the thyroid and irradiation.

Cancer of the thyroid and irradiation.


Hepatic pathology in jaundice due to chlorpromazine.


Treatment of enterobiasis and ascariasis with piperazine.


Chronic postherpetic neuralgia.

Chronic postherpetic neuralgia.


Nephrotic syndrome in congenital quartan malaria.


Acute adrenal cortical insufficiency; precipitation by infection during prolonged cortisone treatment.


Massive hemorrhage occurring during bronchoscopy.


Agammaglobulinemia; report of a case.

Agammaglobulinemia; report of a case.


Griess' nitrite test in diagnosis of urinary infection.


Copper metabolism in man.

Copper metabolism in man.


Research approach to atherosclerosis.

Research approach to atherosclerosis.


CHRONIC subluxating ankle.

CHRONIC subluxating ankle.


Importance of biological research in industrial medicine.


A physician looks at athletics.

A physician looks at athletics.


Deaths following electrotherapy; report of five deaths, with autopsy findings in four cases.


Neuropsychiatric sequelae of prematurity; a longitudinal study.


Long-term follow-up of patients who received 10,098 spinal anesthetics; syndrome of decreased intracranial pressure (headache and ocular and auditory difficulties).


Palatine petechiae, an early sign in infectious mononucleosis.


Results of mobilization of fixed stapedial foot plate in otosclerotic deafness.


Control of chronic pain by DL-alpha acetylmethadol.


Hydroxyzine (atarax) hydrochloride in dermatological therapy.


Intravenously given urographic mediums; comparative study of eight hundred cases.


Study of five hundred patients with asymptomatic microhematuria.


Evaluation of the serum glutamic oxalacetic aminopherase (transaminase) test; its use in diagnosis of acute myocardial infarction.


Use of methallenestril (vallestril) in control of menopausal symptoms.


Device for improving nasogastric suction.


New adaptation to the standard three-way stopcock.


Venostomy, an improved cut-down procedure in infants and children.


Food pump; new approach to tube feeding.


Folic acid and vitamin B12 in medical practice.


Oak Ridge radioiodine (I131) for hyperthyroidism; tenth anniversary.


The family doctor.

The family doctor.


Laboratory procedures as an emotional stress.


Cardiovascular case progress index; method of classifying chronic diseases, with mechanism of long-term follow-up and a preliminary report of the first fifteen hundred cases.


Treatment of enterobiasis with one oral dose of promethazine hydrochloride.


Oral mucosal smears in detection of genetic sex.


Physiological approach to ambulation in paraplegia.


Varied manifestations of dissecting aneurysm of the aorta.


Severe toxic effects from aminophylline and theophylline suppositories in children.


Medical education based on interdepartmental cooperation.


The university in medicine; concept of the new program at the University of Florida.


Teaching the family physician's approach, as built around general practitioners.


The resident clinical clerkship; an experiment in medical education.


Teaching of family physician's approach by a department of preventive medicine.


An advisor (preceptor) program for interns at a general hospital.


Allergic eczematous contact dermatitis due to metallic nickel.


New apparatus for treatment of pulmonary edema.


Mechanical respirator for newborn infants and other patients; preliminary report.


Unusual skin lesions associated with thrombosis of subclavian artery.


Alopecia areata due to syphilis.

Alopecia areata due to syphilis.


Current trends in the feeding of infants and children.


Clinical lessons learned in the morgue.

Clinical lessons learned in the morgue.


DR. DAVID B. ALLMAN; president-elect.

DR. DAVID B. ALLMAN; president-elect.


DR. BIERRING receives distinguished service medal.


Immunogenicity, in children, of ultraviolet-treated poliomyelitis vaccine.


Prognostic studies in children with cerebral palsy.


Preservation and transfusion of blood.

Preservation and transfusion of blood.


Insulin resistance.

Insulin resistance.


Results of subtotal gastric resection (Billroth 2 type) for duodenal ulcer.


Diabetes of thirty-five years' duration.


Effect of bishydroxycoumarin (dicumarol) on clotting time of whole blood.


Value of chlorpromazine in preoperative medication.


Five-year follow-up of patients subjected to three different lobotomy procedures.


Hemodialysis, an effective therapy for acute barbiturate poisoning.


A treatment program for the alcoholic in industry.


Environmental support in long-term illness; practical management and prevention of invalidism.


Clinical effects of azapetine (ilidar) on peripheral arterial disease.


Myleran therapy in malignant neoplastic disease; use of 1,4-dimethanesulfonyloxbutane with emphasis on chronic granulocytic leukemia.


Treatment of checkrein shoulder by use of manipulation and cortisone.


Factors affecting normal expectancy of conception.


Paraplegia secondary to abdominal aortography.


New method of preparing concentrated erythrocytes for transfusion.


Effect of Rauwolfia alkaloids on the excretion of uropepsin in the human.


Pyroglobulinemia; diagnostic clue in multiple myeloma.


Diffusion of alcohol through stomach wall after death.


Prevention of congenital syphilis by treatment of syphilis in pregnancy.


Agranulocytosis and scarlatiniform eruption due to phenindione.


Use of bulb and bag set in aerosol therapy.


Skull fracture in ten-day-old infant.

Skull fracture in ten-day-old infant.


Report on the use of a plastic tracheotomy plug in postpoliomyelitic patients.


Anomalous type of salt and water retention with persistent edema.


Plaquenil in the treatment of lupus erythematosus.


Vitamin nutrition, infections, and antibiotics.


TETANUS immunization.

TETANUS immunization.


AMINO acid imbalance and supplementation.


Rauwolfia compounds in the treatment of Parkinsonism.


Is juvenile delinquency a medical problem?


Severe anemia.

Severe anemia.


Medical work in India.  II.

Medical work in India.  II.


Prevention of blindness.

Prevention of blindness.


How the AMWA can help me in the pursuit of my career.


Aspects of prognosis for patients referred for psychotherapy.


Lena Kellogg Sadler.

Lena Kellogg Sadler.


Ella A. Mead.

Ella A. Mead.


Osteopathic manipulative therapy in geriatric practice.


Emphysema, a pneumonic and circulatory problem with neuromuscular mechanisms.


Conservative management of fractures.

Conservative management of fractures.


Whiplash injuries; management and complications.


Traumatic meniscal lesions of the knee.

Traumatic meniscal lesions of the knee.


Osteoid osteoma.

Osteoid osteoma.


Intramedullary nailing of the tibia in relationship to avascularity at the fracture site, with a review of eight cases.


Fractures of the hip; a five-year survey of hip fractures and the advantages of professional teamwork.


Hip fractures; a problem of the aged.

Hip fractures; a problem of the aged.


Fracture immobilization with intramedullary Kirschner wires and with Parham bands.


Physical medicine and rehabilitation as a specialty.


The role of the specialist in physical medicine and rehabilitation in the practice of osteopathic medicine of today.


Physical medicine in the rehabilitation of the orthopedic patient.


The role of primitive stresses in civilized life.


The effect of unilateral static exercises on blood pressure.


Pathologic manifestations of the arteriosclerotic state.


The osteopathic hospital system; its opportunities and responsibilities in the service of health.


What's going on in congress.

What's going on in congress.


Cutting costs and avoiding waste by proper planning.


Standardization of hospital accounting systems.


Training of nursing aides and auxiliary helpers.


Standardization of statistics.

Standardization of statistics.


Employee morale.

Employee morale.


Management controls and reports.

Management controls and reports.


Photolysis of vitamin B12.

Photolysis of vitamin B12.


Pharmaceutical and toxicological studies on the polyuronide of sapote gum.


A comparison of dichloralphenazone and chloral hydrate.


The effect of various substances on the antibacterial activity of bacitracin in ointments.


The stability of almond and corn oils for use in parenteral solutions.


The use of cocoa syrups for masking the taste of quinine hydrochloride.


Composition of gum turpentines of pines.  XXVI.  A report on Pinus lawsoni and P. herrerai from Michoacán, Mexico, and P. ponderosa from the California coast.


Interaction studies of cationic drugs with anionic polyelectrolytes.  I.  Sodium carboxymethylcellulose.


A study of cocoa syrups for taste preference.


The effect of certain non-narcotic analgetics on diuresis and liver sulfhydryl concentration in the albino rat.


Prediction of stability in pharmaceutical preparations.  II.  Vitamin stability in liquid multivitamin preparations.


Composition of gum turpentine of pines.  XXVII.  A report on three Mexican pines:  Pinus pringlei and P. michoacana from Michoacan and P. arizonica from Chihuahua.


Preparation and properties of 8-chlorotheophylline salts of some nitrogen bases.


The goldfish as a potentially useful animal for testing neurotoxicity of antibiotics.


Analysis of phenobarbital in pharmaceuticals by Argentimetric potentiometric titration.


A note on an electrolytic synthesis of I131 labeled iodoform.


Antibiotics and thyroid tissue slices.

Antibiotics and thyroid tissue slices.


PROPOSED international non-proprietary names.  List IV.


Two cyclic analogs of acetylcholine.

Two cyclic analogs of acetylcholine.


The chemical evaluation of Rauwolfia serpentina preparations.


The effect of various preservatives on microorganisms isolated from deteriorated syrups.


An investigational study of hydroxy aluminum magnesium aminoacetate, a new antacid.


Modern ointment base technology.  II.  Comparative evaluation of bases.


1-Phenyl-2-amino-3-methoxy-1-propanol hydrochloride and related compounds.


Anticoagulant sulfuric acid esters of synthetic polyglucoses.


A pharmacologic study of combinations of antihistaminic substances.


A paper chromatographic study of aloe, aloin and of cascara sagrada.


A simplified assay of Nux vomica tincture.


The toxic component of the singletary pea (Lathyrus pusillus).


Ultrasonic extraction of Cinchona succirubra.


The melting point of suppositories; device for testing the resistance of fatty-base suppositories to deformation.


Extraction of Cinchona succirubra with tetrahydrofuran and its mixtures.


Digitalis studies by the U.S.P. XIV method of assay.  I.  Seasonal variation in response of the pigeon to digitalis.


Digitalis studies by the U.S.P. XIV method of assay.  II.  Stability of crude digitalis leaf.


A new approach to the chemistry of aromatic ammonia spirit.


Sabadilla alkaloids.  V.  Vanilloylcevine.


P-Hydroxybenzoic acid esters as preservatives.  II.  Acute and chronic toxicity in dogs, rats, and mice.


p-Hydroxybenzoic acid esters as preservatives.  III.  The physiological disposition of p-hydroxybenzoic acid and its esters.


A note on the determination of some alkali salts of organic acids by ion exchange.


Derivatives of 3-, 4-, and 5-phenylsalicylamides.


Studies on the toxicity of acetoglycerides.


An investigation of triterpenes as steroid hormones.


Ion exchange resin dye compounds for use in indirect determination of gastric acidity.


Inhibition of hydrolysis of esters in solution by formation of complexes.  II.  Stabilization of procaine with caffeine.


Study of glycolic acid metabolism in Bryophyllum calycinum Salisb.


Physical properties and pharmacological activity:  antihistaminics.


Studies on Rauserfia; a Rauwolfia derivative.


A vitamin B12 binding substance obtained from L. leichmannii 7830.


Determination of hexachlorophene in liquid soaps.


Zinc oxide hyperfine:  preparation and properties.


Syntheses of amino ethers with potential pharmacological activity.


Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic.


A phytochemical investigation of Dryopteris Hexagonoptera Michaux.


Fungistatic, bacteriostatic, and amebicidal studies on the isomeric normal nonynoic acids.


Comparison of aqueous and repository tubocurarine for muscle relaxant effectiveness and toxicity in rabbits.


Ophthalmic vehicles:  the effect of methylcellulose on the penetration of homatropine hydrobromide through the cornea.


Toxicity, skin irritant properties and absorption of N-n-butyl-3-phenylsalicylamide.


A new approach to the assay of alkaloidal crude drugs.  II.  Ipecac.


A note on the effect of vitamin B12 on the unsaturated fatty acid content of castor oil.


The antituberculous activity of some isonicotinic acid hydrazide congeners and derivatives.


A note on the antiseptic value of certain pectin pastes.


A note on the solubility of strychnine in alcohol and water mixtures.


A note on the preparation of 4-chloro-2-isopropyl-5-methylphenoxyacetamidine hydrochloride.


A note on tablet hardness.

A note on tablet hardness.


The exposure of drugs to the effects of nuclear explosions.


The colorimetric determination of the individual components of acetylsalicylic acid, acetophenetidin and caffeine mixtures.


Estrogenic activity of some flavonoids.

Estrogenic activity of some flavonoids.


The effect of some selected surface-active agents on the extraction of cape aloe.


The effect of triterpenes on the excretion of sodium and potassium by rats.


The in vitro antibacterial activity of oils.


The relation between in vitro disintegration time of sugar-coated tablets and physiological availability of sodium p-aminosalicylate.


Effect of alteration of size of the aromatic dicarboxylic acid nucleus on local anesthetic activity.


Paper chromatography of bile acids.  II.

Paper chromatography of bile acids.  II.


The colorimetric determination of peptic activity.


Glycolysis inhibitors among compounds containing the CON structure.


Illustrations and pharmaceutical interpretations of first order drug elimination rate from the bloodstream.


The assay for tetracycline HCI and chlortetracycline HCI in tetracycline HCI.


Evaluation of an iodonium compound as an antiseptic agent.


Derivatives of arylpolycarbamic acids of pharmacologic interest.


Polarographic determination of pyrazinamide serum and plasma concentration in the presence of isoniazid.


Antispasmodic and related pharmacological actions of some gamma-arylpropylamines.


The accumulation of hordenine in the seedings of Panicum miliaceum.


The fluorometric assay for chlortetracycline HCI and the determination of tetracycline HCI in chlortetracycline HCI.


A note on a plastic insert for adapting Beckman Corex cells to microanalysis.


The synthesis and pharmacology of some polymethylene bisonium compounds.


A note on the isolation of bergapten and imperatorin from the fruits of Pastinaca sativa L.


A note on the metabolism of lysergic acid by Claviceps purpurea (Fries) Tulasne.


A note on a new method of preparation of (bromomethyl) malonic ester.


A note on an indwelling cannula for intraventricular injection of drugs in the unanesthetized dog.


A note on pressor drugs.  VI.  Acute toxicity of epinephrines.


A note on sabadilla alkaloids:  cevadine.


On the experiences of the analyst in the psychoanalytic situation; a contribution to the theory of psychoanalytic treatment.


Countertransference.

Countertransference.


Countertransference:  comments on its varying role in the analytic situation.


Indications and contraindications for the application of the standard technique.


Will and psychoanalysis.

Will and psychoanalysis.


A clinical note on the therapeutic use of a quasi-religious experience.


Some comments on psychoanalysis and dynamic psychiatry.


Recent books on psychoanalytic technique; a comparative study.


In memoriam; George Lane Taneyhill, Jr.

In memoriam; George Lane Taneyhill, Jr.


Ernest Elvin Hadley.

Ernest Elvin Hadley.


Anemia in the cat.

Anemia in the cat.


Whither "National Board" examinations in veterinary licensure?


The veterinarian in time of disaster.

The veterinarian in time of disaster.


Ectopic sesamoid bones at the elbow (patella cubiti) of the dog.


Acute Klebsiella (capsulated coliform) mastitis.


Bluecomb disease of turkeys.  II.  Antibiotic treatment of poults.


The Leeper Animal Hospital.

The Leeper Animal Hospital.


In vitro and in vivo use of antibiotics against Vibrio fetus.


Practical field surgery.

Practical field surgery.


Esophageal obstruction in a cat.

Esophageal obstruction in a cat.


Surgical relief for stenotic nares in a dog.


Homemade oxygen tent equipment for large animal therapy.


The sequence of events preceding death of a cow in acute experimental bloat on fresh alfalfa tops.


Erysipelothrix septicemia in the porpoise.


Recovery of a cow with tetanus.

Recovery of a cow with tetanus.


Rapid antibiotic-sensitivity testing.

Rapid antibiotic-sensitivity testing.


A system of testing vision in animals.

A system of testing vision in animals.


Hematology as an aid in the diagnosis of poultry diseases.


An abnormality of the proventriculus of the chick.


Active and passive protection of mink against type C botulism with type C toxoid and polyvalent antitoxin.


The prevention of virus enteritis of mink with commercial feline panleukopenia vaccine.


SYMPOSIUM from conference of equine practitioners.


Experimental studies relative to the therapeutic use of ultrasound.


Nasal irrigation in the treatment of nasal catarrh and sinus infections in horses.


Surgical removal of fracture fragments of the proximal sesamoid bone.


Local anesthesia and applied anatomy as related to nerve blocks in horses.


Objective examination in veterinary medicine.


Parakeets in veterinary practice.

Parakeets in veterinary practice.


A new method of application of pigeon pox vaccine.


Incidence of leptospira in horses; a laboratory report.


Melanoma of eye and oral mucosa with metastases in a dog.


Some observations on further attempts to transmit equine infectious anemia to lambs and pigs.


The pathogenesis of canine histoplasmosis.


Toxicity studies on captan-treated corn in pigs and chickens.


Neural pathways in lactation.

Neural pathways in lactation.


Some characteristics of myelinated fibre populations.


A note on terminal degeneration in the hypothalamus.


A study of silver degeneration methods in the central nervous system.


The immediate effects of ligature of vasa nervorum.


The functional significance of the pattern of innervation of the muscle quadratus labii superioris of the rabbit, cat and rat.


Observations on the silver impregnation of nerve fibres in teeth.


Observations on the postural mechanism of the human knee joint.


The evolution of the mammalian eardrum and tympanic cavity.


The development of the circulation in the spleen of the foetal rabbit.


Anatomical features of the human renal glomerular efferent vessel.


The distribution of haemopoietic foci in the infantile human liver.


The representation of skull shape by contour drawing.


A rapid method of graphic reconstruction.


Moniliasis.

Moniliasis.


Treatment of tsutsugamushi disease with tetracycline.


Studies on carzinophilin.  I.  The properties of carzinophilin A.


On the classification of antifungal antibiotics.


The mechanism of action of para-aminosalicylic acid in preventing the emergence of resistance to streptomycin in mycobacterium tuberculosis.


Studies on the pyridomycin production.  II.  X-ray irradiation on the pyridomycin-producing strain.


Studies on growth promotion by antibiotics.  I.  Effects of chlortetracycline on growth.


Antifungal substances, No. 720-A and No. 720-B, and probable identity of No. 720-A with antimycin A, virosin, and antipiricullin.


Studies on carzinocidin, an antitumor substance produced by Streptomyces sp.  I.  On extraction, chemical and biological properties of carzinocidin.


Studies on carzinocidin, an antitumor substance, produced by Streptomyces sp.  II.  On antitumor effects of carzinocidin.


The effect of sulfathiazole in preventing the emergency of streptomycin-resistance in the sulfathiazole-resistant strain of Mycobacterium avium.


The mutation rate to streptomycin-resistance in an original sensitive strain and in its isoniazid-resistant mutant of Mycobacterium avium.


Antitumor effect of pluramycin crude powder on Ehrlich carcinoma of mice.  Studies on antitumor substances produced by microorganisms.  X.


Studies on antitumor effect of actinomycin J.


Therapy of present day recalcitrant urinary tract infections.


The significance of bronchial obstruction.


Report on carcinoma of the cervix treated at the South Arkansas Tumor Clinic.


The Doctor and his Medical Society.

The Doctor and his Medical Society.


Spontaneous antepartum rupture of uterus following previous complete inversion; a case report.


The acute gall bladder.

The acute gall bladder.


Icarus and the physician; reflections on aircraft accidents and their prevention.


Transthoracic pressure in man during rapid decompression.


Electrocardiography in the selection of aircrew members; an opinion survey in the Royal Canadian Air Force.


Development of an aviation medicine residency program.


Effects of body chilling upon the blood vessels of denervated and intact kidneys in dogs and rabbits; final report.


Human engineering:  psychophysiology or engineering?


An appraisal of the present method of assessing hearing in aircrews.


Alveolar pCO2 changes resulting from a constant oxygen regulator leak.


Effects of exercise and altitude on the growth and decay of aviator's bends.


Effect of simulated flight stresses on the concentration of serum cholesterol, phospholipid and lipoprotein.


Robert Stanley Breed; October 17, 1877-February 10, 1956.


The pathways of glucose dissimilation by Microbacterium lacticum.


Morphological and physiological characteristics of the genus Chromobacterium.


The nature of some growth stimulatory substances for Lactobacillus delbrueckii.


Anoxia as a major factor causing population changes in antiserum-containing cultures.


Response of Escherichia coli to ferrous ions.  III.  Application of a method for estimating cellular division to a study of recovery and mutation.


Aureomycin-resistant cell-free nitro reductase from aureomycin-resistant Escherichia coli.


Labile citrovorum factor in urine.

Labile citrovorum factor in urine.


A cyclic pathway for the bacterial dissimilation of 2, 3-butanediol, acetylmethylcarbinol, and diacetyl.  I.  General aspects of the 2, 3-butanediol cycle.


Inhibitor studies of diphtherial succinic dehydrogenase.


Threonine deamination in Escherichia coli.  I.  D- and L-threonine deaminase activities of cell-free extracts.


Electron microscopical studies of ultrathin sections in Penicillium chrysogenum.


Studies on the biosynthesis of the M-protein of group A hemolytic streptococci.


A phase contrast study of the chromatinic bodies of Escherichia coli subsequent to ultraviolet irradiation.


Nuclear division as observed in live bacteria by a new technique.


A plating technique for screening intestinal coliform bacteria.


A study of lysis in bacteriophage-infected Escherichia coli.


The effect of various chemical agents on eastern equine encephalomyelitis virus.


Pink yeasts isolated from human skin surfaces.


Effect of prolonged incubation of Escherichia coli on the production of phage T1.


A medium promoting rapid quantitative sporulation in Clostridium perfringens.


Levels of certain free amino acids of chorio-allantois during influenza virus infection.


Conjugal pairing in Escherichia coli.

Conjugal pairing in Escherichia coli.


Preservation of Diplococcus pneumoniae.

Preservation of Diplococcus pneumoniae.


Visualizing bacterial cells for direct microscopic counting on the millipore filter, hydrosol type.


The relation of population heterogeneity to the plateau phenomenon in radiation doso-response curves.


Sensitivity of rat liver xanthine oxidase to amino acid analogues.


Enzymatic carboxylation of beta-hydroxyisovaleryl coenzyme A.


Evidence for complex ion formation in the calcium-bicarbonate system.


Enzymatic conversion of L-fucose to L-fuculose.


On the occurrence, equilibria, and site of acyl-enzyme formation of glyceraldehyde-3-phosphate dehydrogenase.


Metabolism of 1-carbon fragments by surviving uteri from estradiol-treated rats.


Synthesis and biological activity of some triiodinated analogues of thyroxine.


Determination of glyoxalase activity.

Determination of glyoxalase activity.


The oxidation of ribonuclease with performic acid.


Peptides obtained by tryptic hydrolysis of performic acid-oxidized ribonuclease.


The lipides of rat liver cell fractions.


Transglycosylation during the mixed digestion of hyaluronic acid and chondroitin sulfate by testicular hyaluronidase.


Exchange of free fatty acids and glyceride fatty acids during fat digestion in the human intestine.


Dialkylfluorophosphatase of kidney.  IV.  Dissociation constant of active groups.


Dialkylfluorophosphatase of kidney.  V.  The hydrolysis of organophosphorus compounds.


An isotope tracer study of glucose catabolism pathways in liver.


Metabolism of essential fatty acids.  III.  Isolation of 5,8,11-eicosatrienoic acid from fat-deficient rats.


The wheat leaf phosphatases.  I.  A survey of the inhibitors at pH 5.7.


Transfer of oxygen in the glutamine synthetase reaction.


On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A.  III.  Palmityl coA dehydrogenase.


The specificity of pancreatic lipase for the primary hydroxyl groups of glycerides.


Studies on an oxalacetic carboxylase from liver mitochondria.


Phosphoacetylglucosamine mutase of Neurospora.


Fractionation of the proteins of human synovial fluid and plasma.


The metabolism of protocatechuic acid by Neurospora.


Incorporation of carbon atoms 1 and 6 of glucose into protocatechuic acid by Neurospora.


Inhibition studies with peptides of thienylalanine and phenylalanine.


Solubilization and purification of the diphosphopyridine nucleotidase from beef spleen.


Mechanisms in enzymatic transamination; effect of alpha-ketoglutarate concentration on the rate of exchange of the hydrogen of aspartate.


An enzymatic cleavage of the cholesterol side chain.


Phosphorylation coupled to oxidation in bacterial extracts.


The rôle of polyglutamyl pteridine coenzymes in serine metabolism.  I.  Cofactor requirements in the conversion of serine to glycine.


The rôle of polyglutamyl pteridine coenzymes in serine metabolism.  II.  A comparison of various pteridine derivatives.


The determination of serum bicarbonate by flame photometry.


The occurrence of N-methyl-2-pyridone-5-carboxylic acid and its glycine conjugate in normal human urine.


Corticotropins (ACTH).  VIII.  The action of pepsin on alpha-corticotropin and the C-terminal amino acid sequence.


Synthesis of succinate from propionate and bicarbonate by soluble enzymes from liver mitochondria.


The utilization of purines by purineless mutants of Aerobacter aerogenes.


Protection of cholinesterase by ethanol against inhibition by organophosphates in vitro.


The carboxylation of propionic acid by liver mitochondria.


The copper-promoted decomposition of vitamin B12 in solutions of ascorbic acid.


Preparation and properties of D-rhamnulose (6-deoxy-D-fructose) and glucosyl rhamnuloside.


Studies on succinic dehydrogenase.  I.  Preparation and assay of the soluble dehydrogenase.


The preparative isolation of cerebrosides.


Quantitative studies on metabolites of tryptophan in the urine of the dog, cat, rat, and man.


An enzymatic route to L-alpha-glycerylphosphorylcholine.


A simple method for assaying adenosine triphosphate and adenosine diphosphate in mixtures.


Plant phospholipase D.  II.  Inhibition of succinic oxidase by cottonseed phospholipase D.


Preferential hydrolysis of glucosidic bonds of maltooligosaccharides by salivary amylase.


Aerobic and anaerobic biosynthesis of amino acids by bakers' yeast.


Carbohydrate oxidation by Pseudomonas fluorescens.  V.  Evidence for gluconokinase and 2-ketogluconokinase.


Studies on the biosynthesis of carbamylaspartic acid.


Enzymatic synthesis of beta-D-galactosides of N-acetyl-D-glucosamine by various mammalian tissues.


Homogentisate metabolism:  the isomerization of maleylacetoacetate by an enzyme which requires glutathione.


The reduction of inorganic iron and cytochrome c by flavin enzymes.


Further studies of the metabolism of taurine-S35 by the rat.


The synthetic activity of prostatic phosphatase in the presence of cytidine and inorganic phosphate.


The biosynthesis of histidine:  imidazoleacetol phosphate transaminase.


Effect of phosphate and other factors in potato extracts on amylose formation by phosphorylase.


Determination of vitamin E in blood.

Determination of vitamin E in blood.


The incorporation of serine-3-C14 into citrovorum factor.


Influence of 1,2-alkanediols on growth of Lactobacillus casei 280-16.


Oxidation of acetaldehyde by Acetobacter suboxydans.


On the mechanism of action of aconitase.


Purine-metabolizing enzymes of Tetrahymena pyriformis.


The identification of C19 steroids in bovine feces.


The oxidation of adrenaline by ferritin iron and hydrogen peroxide.


Mechanism of the catalytic oxidation of adrenaline by ferritin.


Structural evidences for chelation and Schiff's base formation in amino acid transfer into cells.


Metabolism of essential fatty acids.  IV.  Incorporation of linoleate into arachidonic acid.


Metalchelated pyridoxylidene derivatives of glycine and alpha, gamma-diaminobutyric acid.


Metabolism in the rat of three amino acids lacking alpha-hydrogen.


Phosphorylation by particulate preparations of Azotobacter vinelandii.


Turbidimetric measurement of acid mucopolysaccharides and hyaluronidase activity.


Electrophoresis of cationic proteins on filter paper.


Amino acid supplementation and voluntary alcohol consumption by rats.


Tracer studies of acids of the tricarboxylic acid cycle.  II.  Effect of fructose and bicarbonate on acetate metabolism in livers of diabetic rats.


A study of formaldehyde-C14,D2 as a one-carbon metabolite in the rat.


Progesterone as a precursor of testicular androgens.


Biosynthesis of the purines.  X.  Further studies in vitro on the metabolic origin of nitrogen atoms 1 and 3 of the purine ring.


Phosphorylation accompanying the oxidation of glutamate by the Madrid E strain of typhus rickettsiae.


Biosynthesis of the purines.  IX.  Precursors of the nitrogen atoms of the purine ring.


Effect of aminopterin administration on the metabolism of liver and small intestine of guinea pigs and rats.


Complexity of the mixture of the higher fatty acids from the lipides of the tubercle bacillus.


Persistent characteristics of the higher fatty acids from the lipides of the tubercle bacillus.


Metabolism of cholesterol in the chick embryo.  II.  Isolation and chemical nature of two companion sterols.


The cardioactive metabolites of digitalis glycosides.


The utilization of nucleotides by the mammal.  IV.  Triply labeled purine nucleotides.


The utilization of nucleotides by the mammal.  V.  Metabolism of pyrimidine nucleotides.


Simplified liquid emulsion radioautography.


The biosynthesis of shikimic acid from D-glucose.


The effect of adenosine upon esterification of phosphate by erythrocyte ghosts.


The role of the photographer in medical education.


A new monochrome application for a highlight mask.


Truth in biological photography.

Truth in biological photography.


A device for rapid photomicrography.

A device for rapid photomicrography.


Tripod and focus mirror for operating room use.


Design of a slide mounting table.

Design of a slide mounting table.


Training medical photographers.

Training medical photographers.


Projection practice.

Projection practice.


The action of corticotropin (ACTH) on nucleic acids and subcellular elements of the adrenal cortex. It was shown experimentally that ACTH causes an increase of cytoplasmic RNA and subcellular granules of the adrenal cortex shortly after administration. This effect was found to be concentrated primarily on the basophilic cytoplasmic granules and to be largely independent of cell division. The increase of nuclear RNA, DNA, and nuclear mass followed that of the cytoplasm. The observations indicate also that the mass increase of mitochondrial and chromidial systems is closely related to the increase in cytoplasmic, largely chromidial RNA.


Chemical differentiation of nuclear proteins during spermatogenesis in the salmon. By means of qualitative staining experiments the characteristic protein changes which occur during maturation of salmon sperm can be followed. It can be observed that the replacement of histone by protamine takes place after completion of meiosis during an advanced stage of spermiogenesis.


A comparison of nuclear dry weights determined by chemical and by interferometric methods. 1. The nuclei of cells from the thymus of the calf were isolated by three different techniques; the citric acid, the sucrose-calcium chloride, and the non-aqueous. 2. The mean dry weights of the nuclei were determined by chemical methods and by microscopic interferometry. There was a close correlation between the results from the interferometric and chemical methods. 3. The range of values about that mean was determined in each sample: the nuclei isolated in aqueous media contained approximately 45 per cent less material than those isolated in non-aqueous media. 4. The variations in dry weight with varying nuclear type are discussed. 5. The possible relationship between DNA content and dry weight is discussed.


Isolation and properties of liver cell nucleoli. 1. The significance of the term nucleolus has been discussed. 2. A detailed method for the isolation of nucleoli from already isolated rat or cat liver nuclei has been presented. 3. The presence of DNA in isolated liver cell nucleoli has been indicated by histochemical methods. 4. The percentages of DNA and RNA in the isolated nucleoli have been determined by chemical analysis. 5. The specific activities of aldolase, arginase, and catalase have been determined for two subnuclear fractions and for the isolated nucleoli of rat and cat liver, and the relative amounts of these enzymes in the same subnuclear fractions and nucleoli of rat liver have been measured. 6. The significance of the above findings has been discussed and consideration has been given to what types of isolated nuclei might best serve as starting material for the isolation of nucleoli. 7. A new hypothesis has been presented that nucleoli of the liver cell type may function primarily in furnishing (directly or indirectly) templates for the synthesis of the particular enzymes that must govern the chemistry of mitosis.


Electron microscopy of basophilic structures of some invertebrate oocytes.  II.  Fine structure of the yolk nuclei. RNA containing yolk nuclei from the surf clam Spisula solidissima have been studied with the light microscope and with the electron microscope. A variety of structures can be seen with both and a correlation can be made between bodies studied with the electron microscope and those studied with the light microscope. The electron microscope shows many of these structures to be composed of double walled lamellae arranged in space, in various ways. The variety of patterns seen with the electron microscope can be satisfactorily explained on the basis of a hypothetical model. The presence of yolk platelets within the yolk nuclei lends support to classical observations on the synthesis of yolk within yolk nuclei or yolk nuclei derivatives. Small granules (about 100 A) are included within the double walled lamellae and their presence probably accounts for the basophilic nature of the entire body. The presence of small granules attached to electron-dense layers relates the yolk nuclei described here to ergastoplasm discussed by others.


Electron microscopical study of skeletal muscle during isotonic (afterload) and isometric contraction. Bundles of the curarized semitendinosus muscle of the frog were fixed during isotonic (afterload) and isometric contraction and the length of the A and I bands investigated by electron microscopy. The sarcomere length, during afterload contraction initiated at 25 per cent stretch, varied depending on the afterload applied between 3.0 and 1.2 micro, i.e. the shortening amounted to 5 to 50 per cent. The shortening involved both the A and I bands. Between a sarcomere length of 3.0 to 1.7 micro (shortening 5 to 35 per cent) the A bands remained practically constant at about 1.5 micro (6 to 8 per cent shortening); the length of the I bands decreased from 1.4 to 0.3 micro (80 per cent shortening). Below a sarcomere length of 1.7 to 1.2 micro the A bands shortened from 1.5 to 1.0 micro (from 6 to 8 to 25 per cent). At sarcomere lengths 1.6 to 1.2 micro the I band was replaced by a contraction band. During isometric contraction the A bands shortened by about 8 to 10 per cent; the I bands were correspondingly elongated.


Liver microsomes; an integrated morphological and biochemical study. Rat liver, liver homogenates, and microsome fractions separated therefrom were examined systematically in the electron microscope in sections of OsO(4)-fixed, methacrylate-embedded tissue and pellets. It was found that most microsomes are morphologically identical with the rough surfaced elements of the endoplasmic reticula of hepatic cells. They appear as isolated, membrane-bound vesicles, tubules, and cisternae which contain an apparently homogeneous material of noticeable density, and bear small, dense particles (100 to 150 A) attached to their outer aspect. In solutions of various osmolar concentrations they behave like osmometers. The findings suggest that they derive from the endoplasmic reticulum by a generalized pinching-off process rather than by mechanical fragmentation. The microsome fractions contain in addition relatively few vesicles free of attached particles, probably derived from the smooth surfaced parts of the endoplasmic reticula. Dense, peribiliary bodies represent a minor component of the same fractions. The microsomes derived from 1 gm. wet weight liver pulp contained (averages of 10 experiments) 3.09 mg. protein N, 3.46 mg. RNA (RNA/protein N = 1.12), and 487 microg. phospholipide P. They displayed DPNH-cytochrome c reductase activity and contained an alcohol-soluble hemochromogen. The microsome preparations proved resistant to washing and "aging." Treatment with versene and incubation with ribonuclease (30 minutes at 37 degrees C.) resulted in appreciable losses of RNA and in partial or total disappearance of attached particles. Treatment with deoxycholate (0.3 to 0.5 per cent, pH = 7.5) induced a partial clarification of the microsome suspensions which, upon centrifugation, yielded a small pellet of conglomerated small, dense particles (100 to 150 A) with only occasionally interspersed vesicles. The pellet contained approximately 80 to 90 per cent of the RNA and approximately 20 per cent of the protein N of the original microsomes. The supernatant accounted satisfactorily for the materials lost during deoxycholate treatment. The findings suggest that the microsomal RNA is associated with the small particles whereas most of the protein and nearly all of the phospholipide, hemochromogen, and DPNH-cytochrome c reductase activity are associated with the membrane or content of the microsomes.


A method for the histochemical differentiation of cholesterol and its esters. Free cholesterol is demonstrated in formalin-fixed frozen sections when treated successively by digitonin, alcohol-ether, and the Schultz technique, in which circumstances cholesterol esters are not visualized. Cholesterol esters and free cholesterol are both demonstrated in comparable sections treated by the Schultz method alone, so that the difference between such sections indicates the sites at which cholesterol esters may be considered present.


Chromosomal structures in crayfish spermatocytes.


A note on homogenizers for tissue brei preparation.


Helical structures in the nucleus of Amoeba proteus.


Major exarticulations for malignant neoplasms of the extremities:  interscapulothoracic amputation, hip-joint disarticulation, and interilio-abdominal amputation; a report of end results in 228 cases.


Circumduction fusion of the spine.

Circumduction fusion of the spine.


The effect of anticoagulant therapy on bone repair.


Congenital pseudarthrosis of the tibia treated by intramedullary nail.


Reconstructive surgery of hands with injured central metacarpophalangeal joints.


Paralytic supination contracture of the forearm.


A rational approach to the surgical needs of the cerebral palsy patient.


Immunological factors in homogenous-bone transplantation.  II.  Histological studies.


Tibioperoneal tenoplasty for congenital club-foot with peroneal insufficiency.


Fibrous dysplasia; histological study of two unusual cases.


Sternomastoid tumor in identical twins.

Sternomastoid tumor in identical twins.


Fractures of the triquetrum.

Fractures of the triquetrum.


Chondrosarcoma of the proximal portion of the femur treated by resection and bone replacement; a six-year result.


Treatment of ununited fracture of the carpal navicular by styloidectomy of the radius.


The anatomy of lumbosacral posterior rami and meningeal branches of spinal nerve (sinu-vertebral nerves); with an experimental study of their functions.


Late effects (twenty-five to forty years) of the early medical and industrial use of radioactive materials; their relation to the more accurate establishment of maximum permissible amounts of radioactive elements in the body.  III.


Upper-extremity prostheses in juvenile amputees.


Immobilization with resinimpregnated plaster bandages.


ALBIN LAMBOTTE; 1866-1955.

ALBIN LAMBOTTE; 1866-1955.


John Albert Key; 1890-1955.

John Albert Key; 1890-1955.


Functional bracing of the arm.  I.

Functional bracing of the arm.  I.


Tumors of the hand.

Tumors of the hand.


Non-suppurative osteitis pubis in the female.


Meniscus injuries of the temporomandibular joint.


A preliminary study of selective plantar-muscle denervation for pes cavus.


The importance of plantar muscles in paralytic varus feet; the results of treatment by neurectomy and myotenotomy.


Experiences with lengthening of the femur over n intramedullary rod.


The osteogenetic phases of regeneration of bone; a historial and experimental study.


Treatment of low-back and sciatic pain by the injection of hydrocortisone into degenerated intervertebral discs.


Homogenous epiphyseal-cartilage grafts; an experimental study.


An autoradiographic study of organically bound carbon-14 in growing epiphyseal cartilage and bone.


Studies of the localization of radioactive gallium (Ga72) in bone lesions.


Bone metabolism.  III.  The effect of various diets on the mobilization of strontium from the rat skeleton.


The localization of chloride in hyaline cartilage by histochemical technique.


Skeletal cryptococcosis (torulosis); report of a case and review of the literature.


Arterial injury in orthopaedic surgery.

Arterial injury in orthopaedic surgery.


Quadriceps cineplasty in a patient with bilateral lower-extremity amputations.


The naviculo-capitate fracture syndrome.


A modified hand drill.

A modified hand drill.


A universal-length dual-pin plate for transfixion of the upper portion of the femur.


A broaching Smith-Petersen nail starter.


HERMAN CHARLES SCHUMM; 1889-1955.

HERMAN CHARLES SCHUMM; 1889-1955.


Don't throw away the cane.

Don't throw away the cane.


Drug effects as modified by aging.

Drug effects as modified by aging.


Anterior and posterior wall infarction of the heart:  a statistical comparison based on autopsy findings.


The treatment of severe arterial hypertension with pentolinium.


Structural alterations with aging in the nervous system.


Studies of the arterial pulse wave.  I.  The normal pulse wave and its modification in the presence of human arteriosclerosis.


Parent participation program in pediatric oncology; a preliminary report.


Medical research:  a medical specialty?

Medical research:  a medical specialty?


Paralysis agitans.

Paralysis agitans.


Nephrosis of childhood:  statistical evaluation of the effect of adrenocortical-active therapy.


An unusual instance of thyroxine-binding by human serum gamma globulin.


Effect of exogenous corticotropin on the histochemical pattern of the human adrenal cortex and a comparison with the changes during stress.


Renal response to ammonium chloride in glycosuric osteomalacia.


Species variations in the response of serum proteins, lipids and lipoproteins to the cortisones.


The diurnal variation of plasma levels and urinary excretion on 17-hydroxycorticosteroids in normal subjects, night workers and blind subjects.


Increased intermedin-like activity in the blood of patients with duodenal ulcer.


Studies on obesity.  III.  Effect of ascorbic acid on the insulin-glucose tolerance curve.


Effect of prednisone and prednisolone on thyroid function, with special reference to thyroxine-binding protein in nephrosis.


A MATTER of great importance to medicine; the plight of the Armed Forces Medical Library.


Cortisone therapy of rheumatic fever:  relation of clinical response to levels of serum protein-bound iodine, serum corticoids and urinary 17-ketosteroids.


Chromatin test in Klinefelter's syndrome.


A case of insulin resistance treated with corticotropin.


Sexual and somatic precocity with some features of Cushing's syndrome in a 2-year-old male.


Improved automatic feed in the Laksh-Manan-Lieberman apparatus for gradient elution chromatography.


Amphenone:  toxicity and effects on adrenal and thyroid function in man.


Lack of secretion of 17-hydroxycorticosteroids in a pregnant woman with Addison's disease.


A clinical appraisal of radioiodine tests of thyroid function.


Chromatophorotropic activity of human blood:  review of 1,200 cases.


An evaluation of the prophylactic use of cortisone for pituitary operations.


Endocrine activity in anorexia nervosa.

Endocrine activity in anorexia nervosa.


A systematic evaluation of the Nelson-Samuels plasma 17-hydroxycorticosteroid method.


Steroid replacement in aged men.

Steroid replacement in aged men.


Hirsutism in infantile thyroid insufficiency.


Effect of intravenous testosterone on nitrogen balance in man.


Cytologic tests of sex in congenital testicular hypoplasia.


Insulin-sparing sulfonamides.

Insulin-sparing sulfonamides.


The properdin system and immunity.  IV.  The hemolysis of erythrocytes from patients with paroxysmal nocturnal hemoglobinuria.


Evidence for the insulin-directed specificity of rabbit anti-insulin serum.


The metabolism of iodotyrosines.  I.  The fate of mono- and di-iodotyrosine in normal subjects and in patients with various diseases.


The production and identification of antibodies to insulin and their use in assaying insulin.


A study of the relative binding capacity of plasma proteins, intact human red cells, and human red cell stroma for radioactive I-131 labeled L-thyroxine.


Placental passage of 17-hydroxycorticosteroids:  comparison of the levels in maternal and fetal plasma and effect of ACTH and hydrocortisone administration.


The effect of acute elevation of the plasma chloride concentration on the renal excretion of bicarbonate during acute respiratory acidosis.


Gastrointestinal water and electrolytes.  I.  The equilibration of radiosodium in gastrointestinal contents and the proportion of exchangeable sodium (Nae) in the gastrointestinal tract.


The effect of glucagon on carbohydrate metabolism in normal human beings.


Excretion of hydroxyproline in patients with rheumatic and non-rheumatic diseases.


Total sodium, potassium and chloride in adult man.


Surgical hypoparathyroidism precipitated by onset of the menopause:  a case report.


Gastrointestinal water and electrolytes.  II.  The equilibration of radiopotassium in gastrointestinal contents and the proportion of exchangeable potassium (Ke) in the gastrointestinal tract.


The action of heparin in the prevention of prothrombin conversion.


The miscible pool and turnover rate of hydrocortisone in man.


Bilirubinprotein linkages in serum and their relationship to the van den Bergh reaction.


Erythrocyte preservation.  VI.  The storage of blood with purine nucleosides.


The causal role of plasma albumin deficiency in experimental nephrotic hyperlipemia and hypercholesteremia.


On the presence of ferritin in the peripheral blood of patients with hepatocellular disease.


A comparison of the metabolic and circulatory effects of epinephrine, nor-epinephrine and insulin hypoglycemia with observations on the influence of autonomic blocking agents.


Observations on the early elevation of serum potassium during respiratory alkalosis.


Distribution of sulfate ion across semi-permeable membranes.


The relationship of pulmonary compliance to pulmonary vascular pressures in patients with heart disease.


An experimental test of the glucostatic theory of regulation of food intake.


Effect of cervico-thoracic ganglionectomy on the adrenaline and noradrenaline content in the mammalian heart.


Sites of water exchange between the maternal system and the amniotic fluid of rabbits.


The alpha2 lipoproteins of human serum; correlation of ultracentrifugal and electrophoretic properties.


Diminished phenylketonuria in phenylpyruvic oligophrenia after administration of L-glutamine, L-glutamate or L-asparagine.


The individual in medical research and the rôle of the university center in his training.


Plethysmographic determination of the volume of gas trapped in the lungs.


Erythrocyte preservation.  VII.  Acid-citrate-dextrose-inosine (ACDI) as a preservative for blood during storage at 4 degree C.


Gigantocotyle explanatum Creplin (Trematoda:  Paramphistomidae) infection of the liver of the buffalo in Ceylon.


The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state; measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm.


The effect of reduction of bacterial infiltration by aureomycin on the normal alimentary lymphoid tissue of the rabbit.


The action of antibiotics and sulphamezathine on the causal agent of virus pneumonia of pigs.


Dual vaccination of dogs against the canine distemper complex and canine virus hepatitis.


Natural and experimental tuberculosis in monkeys; with observations on immunization and chemotherapy.


Eosinophilic myositis in the dog.

Eosinophilic myositis in the dog.


The synergism between pyrimethamine and sulphadimethylpyrimidine in the control of Eimeria tenella.


The chemotherapy of experimental Erysipelothrix rhusiopathiae infection in chicks and turkeys.


Bacteroides infection in kangaroos.

Bacteroides infection in kangaroos.


The blood groups of the pig.  III.  A breed difference in iso-antibody response after vaccination with crystal violet swine fever vaccine.


Effects of sexual reinforcement upon the performance of male rats in a straight runway.


The effect of thalamic lesions upon delayed response-type tests in the rhesus monkey.


Amount of incentive and performance on a black-white discrimination problem.


The relative effectiveness of secondary reinforcers throughout deprivation and habit-strength parameters.


The acquisition of observing responses in the absence of differential external reinforcement.


Weakening of conditioned bar-pressing by prior extinction of its subsequent discriminated operant.


Effect of amount of incentive on discrimination learning by monkeys.


Extinction rate as a function of distribution of practice and of practice sessions.


The secondary reward value of inaccessible food for hungry and satiated rats.


The externalization of hunger and frustration drive.


Species differences in taste preferences.


The maintenance of escape behavior under fixed-ratio reinforcement.


Secondary drive as a neutralizer of time in integrative problem solving.


The duration and course of the reaction decrement and the influence of reward.


Bodyweight changes and behavioral attributes.


Variability of play and exploratory behavior in chimpanzees.


The effect of hypoxia, hyperoxia, and hypercapnea upon audiogenic seizures.


Sound-induced startle response as a function of time since shock.


Exposure of primates to cosmic radiation above 90,000 feet.


Quantitative analysis of forces of the tongue.


Blood loss in oral surgery.

Blood loss in oral surgery.


The effect of artificial water fluoridation on the solubility of tooth enamel.


Investigations of the anti-enzymatic action of fluoride at the enamel surface.


The effect of fluroide on acid formation by salivary sediment.


Determination of fluoride in organic and inorganic fractions of dentin and enamel.


Studies on the physicochemical phenomena related to dental caries.  III.  The effect of sucrose upon the solubility of human dental enamel.


Rapid acid formation resulting from the action of plaque or salivary sediment on sugars.


The fermentation of sorbitol by certain acidogenic oral microorganisms.


The pH levels attained by compact layers of oral microorganisms in contact with glucose solutions.


Oversaturation of saliva with hydroxyapatite.


Dimethylaminobenzaldehyde as a measure for salivary tryptophane.


In vitro studies on the protection of penicillin-sensitive oral acidogenic bacteria by yeasts present in human saliva.


Studies of the composition of teeth.  IV.  The amino acid composition of human enamel protein.


Studies of the composition of teeth.  III.  The amino acid composition of human dentinal protein.


Studies of the composition of teeth.  V.  Variations in the amino acid composition of dentin and enamel.


The lipide content of enamel and dentin.


Observations on sexual similarity and bilateral distribution in dental caries incidence in albino rats and cotton rats.


A comparative study of oral lactobacilli isolated on two different media from the Hunt-Hoppert rats.


The production of chondrosulfatase by microorganisms isolated from human gingival crevices.


Phosphatase, peroxidase, and oxidase activity of dentin and bone.


A method for studying the epithelial attachment.


Effect of rough surfaces upon gingival tissue.


Enamel cuticle.

Enamel cuticle.


A method for the collection of large quantities of rat saliva.


The hypothalamic elaboration of posterior pituitary principles in man, the rat and dog; histochemical evidence derived from a performic acid-Alcian blue reaction for cystine.


The reactivity of the x-irradiated ovary of the rat.


Neurohumoral control of the release of adrenocorticotrophic hormone.


The effect of scrotal insulation and the influence of the breeding season upon fructose concentration in the semen of the ram.


Changes in the mouse after x-ray sterilization.


A comparison of the relative efficacy of methyltestosterone by the gastric and oral transmucosal routes.


The composition of the stallion's semen.


Role of the adrenal cortex regenerated after enucleation in the resistance against histamine shock.


Some observations on the sulphuric acid colour reaction for the estimation of pregnanediol.


Sex differences in length of gestation in mammals.


The number of oocytes in ovarian autografts after freezing and thawing.


Hormonal effects on liver and kidney cytoplasm.


The influence of pituitary growth hormone on plasma insulin activity.


A study of fertilization in the rabbit:  the effect of post-coital ligation of the fallopian tube or uterine horn.


Studies on non-precipitating antibody.  I.  The conversion of non-precipitating antibody to a precipitin-like material in vitro. Brief exposure of serum to alkali in the cold seems to convert non-precipitating antibody to a precipitin-like material. This was disclosed by the following lines of evidence. 1. Immune sera, after addition of antigen and removal of the ensuing precipitates, yielded after alkali treatment more antibody-antigen complex than did sera to which no antigen was added. 2. When immune sera were depleted of precipitating antibody, treated by alkali, and antibody-antigen complex was allowed to precipitate, the resulting supernates formed additional prescipitates upon admixture of specific antigen. No precipitation occurred upon addition of non-specific protein to the treated supemates or the addition of specific antigen to depleted sera not treated by alkali. 3. Alkali-treated immune sera precipitated more antigen than untreated sera.


Studies on nonprecipitating antibody.  II.  Circulating antibody-antigen complex following repeat injections of antigen. Reinjection of antigen into immunized rabbits usually results in an immediate increase of circulating antibody-antigen complex. This immediate formation of complex seems to depend upon the presence of non-precipitating antibody before reinjection. The complex disappears by the 2nd day after reinjection and reappears between the 4th to 7th day. This is earlier than its first appearance after a primary injection and may indicate an anamnestic response of the non-precipitating antibody responsible for the formation of circulating antibody-antigen complex.


The properdin system and immunity.  V.  The bactericidal activity of the properdin system. Methods for the preparation and standardization of reagents suitable for studies on the bactericidal action of the properdin system are described. The preparation and properties of serum free of properdin (RP(b)) are presented in detail because of the necessity for a suitable RP(b) in these studies. The properdin system is responsible for the bactericidal action of normal human serum against a variety of microorganisms. The present work shows that the removal of properdin from serum also removes bactericidal activity. Addition of properdin to properdin-deficient serum restores bactericidal activity. A quantitative relationship exists between the final properdin concentration and bactericidal activity against sensitive organisms. The possibilities of a bactericidal assay for properdin are discussed. It is demonstrated that, in addition to properdin, the four components of complement (present in RP(b)) are necessary for the destruction of properdinsensitive bacteria. If any component is missing, bactericidal activity is lost; when the component is replaced, bactericidal activity is restored. Magnesium is also necessary for the bactericidal activity of the properdin system. Maximal bactericidal activity is obtained with magnesium concentrations similar to that of normal human serum (10(-3) to 10(-4)M). The bactericidal activity of the properdin system occurs only at temperatures above 15 degrees . Resistant strains have been encountered in species of bacteria sensitive to the properdin system. Resistance or sensitivity is a characteristic of the individual strain and not of the species. The widespread occurrence of the properdin system in normal mammalian serum and the variety of bacteria destroyed by it suggest that the properdin system is a factor in natural resistance.


Colicine K.  I.  The production of colicine K in media maintained at constant pH. An apparatus for maintaining the pH of an actively growing bacterial culture at constant level has been described. Using this apparatus it has been shown that the production of maximal amounts of colicine K from a strain of E. coli known as K235 is dependent upon an enriched nutrient medium which is maintained at pH 7.0.


Studies of the bactericidal action of phagocytin. The bactericidal activity of phagocytin on Gram-negative enteric bacilli is influenced by the reaction of the medium; the more acid the environment, the more marked is the activity. Phagocytin exerts approximately the same action whether citrate, acetate, or phosphate salts are used as buffer, and the addition of glucose, casein hydrolysate, or cation binding agents does not produce notable change. Although proteins in general have but little effect, the inclusion in the medium of a high concentration of bovine plasma albumin neutralizes the lethal action of phagocytin on enteric bacilli. Very high concentrations of magnesium or calcium ions antagonize but do not completely block the bactericidal effect. The bactericidal activity of phagocytin is essentially independent of the numbers of bacteria exposed; a 100-fold increase m the numbers of enteric bacilli results in approximately a 2-fold increase in the concentration of phagocytin required to kill 90 per cent of them. When susceptible microorganisms are exposed to phagocytin at 0 degrees C., practically no killing takes place. At higher temperatures the bactericidal action is rapid, being well advanced in 5 minutes and complete within 30 minutes.


Phagocytin:  a bactericidal substance from polymorphonuclear leucocytes. A technique has been developed for collecting large numbers of polymorphonuclear leucocytes from peritoneal exudates in rabbits. These cells are obtained essentially free from other cell types and from debris. When microphages so procured are disrupted by physical methods and extracted with aqueous salt solutions, the soluble fraction manifests striking bactericidal activity, especially on Gram-negative enteric bacilli. The susceptible microorganisms are not lysed. This bactericidal substance, which has been called phagocytin, appears to be limited in distribution mainly to the polymorphonuclear leucocyte. No phagocytin is present in extracts of rabbit heart, kidney, or skeletal muscle, and rabbit liver and spleen contain much less than do packed leucocytes. Extracts of human and of guinea pig microphages show less bactericidal activity than rabbit cell preparations. Similar extracts of rat and mouse polymorphonuclear leucocytes contain no demonstrable phagocytin. As indicated by its behavior on dialysis, on exposure to proteolytic enzymes, and on salt fractionation, phagocytin appears to be a protein with general properties characteristic of a globulin. It is clearly different from lysozyme and from properdin. Although phagocytin is reasonably stable at temperatures of 65 degrees C. and lower for several hours, solutions of it gradually lose bactericidal activity on standing for prolonged periods at 4 degrees C. This instability, and also the ease with which phagocytin is inactivated, presumably by adsorption, on exposure to a variety of materials, have thus far rendered fruitless efforts to isolate it.


Transformation reactions with two non-allelic R mutants of the same strain of Pneumococcus type VIII. Two distinct R mutants of pneumococcus type VIIIS have been described in which the mutations leading to loss of type VIII polysaccharide production are non-allelic. A DNA extract prepared from either R strain restores the capacity to produce type VIII polysaccharide in the other strain. Autologous extracts are inert in this respect. DNA extracts from pneumococcus type IIS when applied to the two R mutants consistently yielded a high proportion of cells transformed to type VIIIS and relatively small numbers of type IIS cells. When extracts prepared from other encapsulated pneumococci, types IS, VIIS, XIVS, and XVIIIS, were applied to R mutant VIII-R1, a mixture of type VIIIS cells and cells corresponding to the type of the donor appeared, although the proportion of type VIIIS cells was not uniformly in excess. The same extracts applied to the second R mutant, VIII-R13, yielded transformed cells of the type of the donor only, or else transformation did not occur. Transforming extracts of a strain of pneumococcus type IIIS gave rise only to type IIIS pneumococci when applied to either strain. Type VIIIS pneumococci were never recovered from such interactions.


A study of plasma protein alterations in rabbits infected with type I pneumococci. An investigation of the plasma protein changes in rabbits infected intradermally with Type I pneumococci has been carried out, utilizing a cationic detergent method of protein fractionation. A consistent pattern of change was observed. There was an increase in the alpha globulins and fibrinogen concentration which reached maximal levels at the height of the infection. Albumin fell to a minimal concentration when the increment of alpha globulins and fibrinogen was greatest. The beta-gamma concentration showed a significant decrease during the most severe phase of the infection but returned to normal several days after spontaneous subsidence of bacteremia. The magnitude of these plasma protein alterations depended on the severity of the infection and the response of the host. Significantly greater changes were observed in rabbits severely bacteremic than in those with mild bacteremia. Administration of penicillin suppressed the infection and decreased the usual plasma protein alterations. Injection of cortisone prior to the onset of the Type I pneumococcus infection caused an early inhibition of the expected plasma protein changes, but later the protein pattem developed in the same manner as it did in the severely infected animals.


Action of x-rays on mammalian cells.

Action of x-rays on mammalian cells. The effects of x-irradiation have been quantitatively studied on single cells of a human cervical carcinoma (HeLa) under conditions such that 100 per cent of the unirradiated cells reproduce in isolation to form macroscopic colonies. This technique eliminates complexities due to interactions of members of large cell populations. Survival of single cells (defined as the ability to form a macroscopic colony within 15 days) yields a typical 2 hit curve when plotted against x-ray dose. The initial shoulder extends to about 75 r, after which a linear logarithmic survival rate is obtained, in which the dose needed to reduce survivors to 37 per cent is 96 r. This radiation sensitivity is tens to hundreds of times greater than that of any microorganism for which the equivalent function bas been studied. Evidence, though not proof, is presented that the lethal effect is due to a radiation-induced genetic defect which, however, cannot be a simple single gene inactivation. The locus of the action could be chromosomal. Beginning at doses of 100 r, or possibly earlier, growth-delaying effects of radiation are visible. Cells in which the ability to reproduce has been destroyed by doses below 800 r, can still multiply several times. At higher doses even a single cell division is precluded. A large proportion of the cells killed by radiation at any dose gives rise to one or more giant cells. These metabolize actively, grow to huge proportions but never reproduce under the experimental conditions employed. Methods of preparing large populations of giant cells are described. These giants are particularly susceptible to virus action. Some of the irradiated cells disappear from the plate, presumably by disintegration. This action of radiation is by far the least efficient, since even after 10,000 r, 5 to 10 per cent of the original cell inoculum is recoverable as giants.


Efficiency of glutamyl peptide polymers as plasma volume extenders. A series of polymers of polyglutamic acid have been tested as plasma volume expanders. The results indicate that those polymers prepared from backbones of 40,000 molecular weight or over and side chains of 3,000 molecular weight or over, will have plasma volume retention half-life of 15 hours or longer. Measurements of the oncotic efficiency of these polymers in vivo indicated a blood stream fluid retention of approximately 51 ml./gm. of polymer. Similar measurements of polymer-serum albumin solutions in vitro showed a retention of 52 ml./gm. of polymer. The clinical response to infusion of solutions of these polymers indicated no untoward pharmacological properties. Although the number of trials presented is too small for ultimate conclusion regarding either the physiological or clinical effects of these polymers, they do provide a strong indication of the desirability of further clinical testing of this polymer and a sound basis on which to plan the larger scale preparation of polymer. Both measures are currently under way.


The localization of skin-sensitizing antibody in the sera of ragweed-sensitive individuals by electrophoresis. Starch electrophoresis was used to separate allergic sera into electrophoretically distinct albumin, alpha-, beta-, and gamma-globulin fractions. The identity of the various fractions was established by free and paper electrophoresis. The gamma-globulin fractions were also characterized by ultracentrifugation. The serum skin-sensitizing antibody to ragweed pollen was shown to be associated with the gamma-globulins in fourteen allergic sera by means of passive transfer technique. The mobility of the skin-sensitizing antibody corresponded to that of gamma-1 and/or gamma-2 globulins. All the other serum fractions were devoid of reaginic activity. Reaginic activity per se was not directly related to protein concentration. The discrepancies between these results, and those obtained by others and ourselves previously are discussed.


An ascites tumor appearing during the passage of Eperythrozoon coccoides in mice. A strain of Eperythrozoon coccoides was maintained in a pure state for 16 months in unsplenectomized Princeton mice by the intraperitoneal injection of parasitized blood, at intervals of 1 to 3 weeks. In the 39th passage three out of five mice developed marked ascites with innumerable neoplastic cells in the peritoneal fluid. By passage of this fluid the tumor cells and the eperythrozoon were transferred together, with the rapid development of ascites and early death of the animals. On continued passage of ascitic fluid and blood from the mice of the 39th successive group both the tumor and the eperythrozoon were ultimately obtained in a pure state. Development of the passaged tumor was uninfluenced by the eperythrozoon but growth of the latter appeared enhanced in the presence of the neoplastic cells. Throughout 50 passages in mice the ascites tumor has not altered in character. The intraperitoneal injection of ascitic fluid was irregularly followed by the appearance of tumor cells in the blood, the rate of the carriage being 26 per cent in sixty-five animals. The subcutaneous and intramuscular injection of the fluid resulted in solid, highly invasive, local growths which did not metastasize. The solid growths proved transferable in series yet after 20 passages still produced the ascites tumor on intraperitoneal injection of their cells.


Studies on bacteriemia.  I.  Mechanisms relating to the persistence of bacteriemia in rabbits following the intravenous injection of staphylococci. During the course of studies on the characteristics of experimental bacteriemia, staphylococci were swiftly cleared from the blood stream of rabbits during the initial 10 to 15 minutes following intravenous injection of microorganisms. A subsequent abrupt decline in the rate of clearance ensued, resulting in a low grade bacteriemia which was demonstrable for many hours. The experiments reported have indicated that this strain of staphylococcus is rapidly phagocyted within the vascular system of rabbits, and that viable staphylococci circulate within the cytoplasm of polymorphonuclear leukocytes. The removal mechanisms contained within the liver and spleen appear to preferentially trap circulating extracellular staphylococci. When most of the circulating staphylococci are contained within leukocytes, splanchnic removal declines or virtually ceases. These observations suggest that viable, intracellular microorganisms are responsible for the persistence of staphylococcal bacteriemia in rabbits following the phase of rapid removal from the blood stream.


Studies on copper metabolism.  XIX.  The kinetics of iron metabolism and erythrocyte life-span in copper-deficient swine. Ferrokinetic studies were performed in three copper-deficient swine and the results have been compared with similar studies in 18 normal pigs. The mean value for the plasma iron turnover rate in the deficient swine was 1.76 mg./kg. day; for the red cell iron incorporation rate, 1.24 mg./kg. day; for the red cell iron turnover rate, 1.18 mg./kg. day; for the red cell life span, 13 days. Corresponding figures in the normal swine were 1.11 mg./kg. day, 1.01 mg./kg. day, 0.59 mg./kg. day and 63 days, respectively. The red cell life span was measured by the use of radioactive chromium in a total of 26 pigs. The mean erythrocyte half-life of normal cells transfused into normal pigs was 17 days. The mean half-life of erythrocytes from copperdeficient swine transfused into copper-deficient swine was 9 days. The mean half-life of red cells from control animals transfused into copper-deficient swine was 16 days while that of erythrocytes from copper-deficient swine transfused into normal pigs, was 13 days. The mean half-life of cells from iron-deficient pigs transfused into iron-deficient pigs was 19 days. It is concluded that copper deficiency anemia results from both a shortened erythrocyte survival time and limited capacity of the bone marrow to produce red cells. It is suggested that copper is an essential component of erythrocytes in swine.


Studies on host-virus interactions in the chick embryo-influenza virus system.  XIII.  Some aspects of non-infectious virus production. Certain aspects of the formation of non-infectious hemagglutinins (NIHA) in the chick embryo infected with influenza virus have been analyzed. It was shown by the use of combined in ovo-deembryonation technics that little or no NIHA is released following infection with small doses of standard virus during the most active and constant growth periods of the virus extending to about the 36th hour of incubation in spite of the fact that multiple infection of cells must have taken place in the latter half of that period. A slight decrease in the ID(50)/HA ratios of the yields obtained after the 36th hour, coinciding with the falling off of virus production and release may possibly be explained in terms of inactivation of completed virus or leakage of as yet incompleted virus from damaged cells. Exposure of the entodermal cells of the allantois of eggs deembryonated shortiy after injection of saturation or near saturation inocula of standard seed to large quantities of infectious virus added to the media at various times after infection and not extending over more than 2 hours resulted in a decrease of the ID(50)/HA ratios of the progenies only during the first 2 or possibly 4 hours after the primary inoculation. Later addition did not influence the yields. As discussed, such sudden and heavy exposures of cells are not expected to occur during the infectious process induced by small inocula of standard seed. The possible role of destruction of cell receptors in NIHA production has been analyzed in several ways. The addition of receptor-destroying enzyme (RDE) to the media of deembryonated eggs after near saturation inocula of standard seeds, if anything, increased the ID(50)/HA ratios of the progenies, and that only when added during the first few hours following infection, presumably by reducing the changes for high multiplicity of infection of cells. In contrast, ultraviolet-inactivated virus, which retains its enzymatic activity, lowered, if anything, the ID(50)/HA ratios of the progenies, when present in the media of deembryonated eggs from the 2nd to 4th or possibly 6th hour after infection. Excessive amounts of irradiated virus may still cause some degree of interference under these conditions. Later addition of irradiated viruses were without effect with respect to NIHA production or interference. In attempts to alter the cell receptors prior to infection by potassium periodate (KIO(4)), it was noted that the addition of glycerol led to the appearance and partial retention for at least 24 hours of substances in the allantoic fluids which were capable of inactivating considerable proportions of standard virus. These data indicate that destruction of external cell receptors plays little if any role in NIHA production. The implications of these findings are discussed.