Antiveratrinic action of the chemical components of chloroquine and some other chlorine substituted compounds.


Experimental production and maintenance of auriculoventricular nodal rhythm in dogs.


Antiarrhythmics.  III.  Antiarrhythmic activity of Nardostachys jatamansi (an Indian indigenous drug).


Studies on Indian medicinal plants; Anisochilus carnosus in anaphylactic reactions of guinea-pig.


Antiarrhythmics.  V.  Tridiurecaine, a new local anaesthetic in experimentally induced atrial flutter, atrial fibrillation and ventricular arrhythmia.


Effect of acetoacetate on the adrenal cholesterol and ascorbic acid of guinea-pigs.


Clinical application of electro-retinography with special reference to clinical manifestation of vitamin-A deficiency, cataract and glaucoma.


Chronic splenomegaly.

Chronic splenomegaly.


An experimental study of the effects of cortisone, DOCA and adrenalectomy on regeneration of liver after partial hepatectomy in albino rats.


Dextraven and intradex as plasma substitutes (plasma volume expanders or restorers).


Some deaths due to fish poisoning (Ichthyosarcotoxism) in India.


Use of coco-nut water in treatment of congestive cardiac failure.


The structure and development of the ileocolic valve and its frenula.


A note on the value of tincture iodine in the local treatment of wounds inflicted by rabid animals.


Changes in the salt concentration of seat during exercise in monsoon weather.


Birth weights and lengths in Bihar State.


Congestive cardiac failure in children.

Congestive cardiac failure in children.


Medical social work for child patients in a hospital.


Treatment of tuberculous meningitis.

Treatment of tuberculous meningitis.


Return to full duty following surgery.

Return to full duty following surgery.


Toxicity of ozone.  I.  Acute toxicity.

Toxicity of ozone.  I.  Acute toxicity.


How much companies pay for medical services.


Occupational hearing loss; Wisconsin's approach to the problem.


Medical and surgical treatment of cirrhosis of the liver.


The optimum time for return to work following various major cardiovascular disabilities.


Varicose veins and stasis problems; the industrial physician's interest and potentialities.


THE LAKE Logan Conference on Occupational Health; the second year's sessions at Canton, North Carolina-May 18-20, 1956.


MIGRAINE and vascular allergy.  II.

MIGRAINE and vascular allergy.  II.


The role of mediators in the inflammatory tissue response.


Transient lung infiltrations with blood eosinophilia.


Some clinical aspects of the diagnosis and treatment of vascular allergy.


Some vascular effects in allergy.

Some vascular effects in allergy.


New serological method for demonstrating sensitivity to allergens.


Some recent developments in psychoendocrinology.


Endocrine concomitants of certain physical psychiatric treatments.


Anxiety states in the army associated with overactivity of the thyroid.


Relaxant effects of meprobamate in disabilities resulting from musculoskeletal and central nervous system disorders; clinical observation of fifty-five cases.


Experimental studies with PM 1090; preliminary report.


DR. FELIX MARTI-IBANEZ appointed professor of history of medicine and director of new department by New York Medical College.


Non-specific mesenteric adenitis.

Non-specific mesenteric adenitis.


A case of Addisonian pernicious anaemia presenting with optic atrophy, iron-deficiency anaemia and pigmentation of the skin.


The production and distribution of milk in County Wexford.


Melkersson-Rosenthal syndrome; report of a case in a female aged 46 years.


An early Victorian surgeon-cardiologist; James Wardrop, 1782-1869.


Toxoplasmosis.

Toxoplasmosis.


Survival after 10 days hepatic coma.

Survival after 10 days hepatic coma.


A note on congenital laryngeal stridor.

A note on congenital laryngeal stridor.


Pre-penile scrotum.

Pre-penile scrotum.


The increase of blood histamine in experimental obstructive jaundice and its causes.


Dual action of ethylurethane on body temperature and gas metabolism of the rats under normal and adrenalectomized condition.


Actions of veratramine on the central nervous system.


A study of metabolism of isoamyl alpha-[N-(beta-diethylamino-ethyl)]-aminophenylacetate (avacan).


Pharmacology of four imidazole derivatives related with histidine.


Pharmacological study on electrical activity and oxygen consumption of brain cortex.


Effects of alcohol, antabuse and acetaldehyde upon the EEG of rabbits.


[Early intervention in patients with mitral disease; emergency mitral surgery; remarks on 210 operative cases].


Studies on serum glutamic oxaloacetic transaminase (SGOT).


The use of the Bardex catheter in anorectal bleeding.


Some recent developments in experimental tuberculosis.


Field tests of telephone transmitted x-ray facsimiles during the past eight years.


The hospital and the patient; some current legal problems.


Hepatosplenography with zirconium oxide.


Electrocardiology in absentia.

Electrocardiology in absentia.


The reduction of 255 pounds, making possible the operation of an irreducible hernia.


Meticorten (prednisone) and meticortelone (prednisolone) in the treatment of allergic disorders.


Treatment of seasonal and perennial allergic rhinitis with prednisone and prednisolone.


A study of behavior patterns in asthmatic children.


Spontaneous and induced allergies of the immediate type in man; a comparative study.


Trichophytin sensitivity of the immediate wheal type; report of a case with unusual manifestations and response to hydrocortisone.


C-reactive protein in allergic diseases.


The significance of C-reactive protein in asthmatic patients.


The effect of hydrocortisone hemisuccinate on tracheal smooth muscle of the guinea pig and cat.


Acute allergic reactions induced in subjects with hay fever and asthma by the intravenous administration of allergens with observations on blood clot lysis.


Alpha [(alpha-methyl-3, 4-methylenedioxyphenylethylamino) methyl]-protocatechuyl alcohol hydrochloride in bronchial asthma.


Asthma produced by synthetic fabrics.

Asthma produced by synthetic fabrics.


Transient myxedema produced by prolonged ingestion of saturated solution of potassium iodide.


Will Cook Spain.

Will Cook Spain.


Smooth surface caries in white rats:  effects of fluoride, iodoacetate, penicillin, crisco, butterfat and a salt mixture.


Morphologic and enzymatic differences in caries-resistant and caries-susceptible albino rats.


Diagnostic aids and vital pulp therapy for deciduous teeth.


Methods of feeding infants with cleft palates.


Facial injuries:  a common denominator of automobile casualties.


Planning a dental prepayment program for children in an area of low caries prevalence.


Root canal obturation.

Root canal obturation.


Determination of monomer content of polymethyl methacrylate.


Relationship between residual monomer and some properties of self-curing dental resins.


The status of local antibiotic therapy in dental infections, with particular reference to penicillin.


Dental and dental hygiene students:  their characteristics, finances and practice plans.  VII.  Practice location plans of dental students.


Processing denture base resins:  heat curing type.


Central giant cell tumor of the mandible.


Food intake and hypnosis.

Food intake and hypnosis.


Protein needs in surgical patients.

Protein needs in surgical patients.


This is your listening life.

This is your listening life.


Communications and participation, facets of personnel relations.


Dietary management of children with diabetes.


Labor in the dietary department; a study of ten hospitals.


Motion study in food service.

Motion study in food service.


Development of future nutritionists in maternal and child health.


Community nutrition experiences for the dietetic intern.


Pathogenetic and allied influences in chronic pulmonary emphysema.


Senile emphysema.

Senile emphysema.


Morbidity and mortality in old age; a study of experience in a modern home for the aged.  I.


Thyroid function and disease in old age.


Psychologic correlates of sex hormone replacement in the aged:  a critique.


PANEL discussion on rheumatic diseases.

PANEL discussion on rheumatic diseases.


Rheumatoid arthritis in the elderly.

Rheumatoid arthritis in the elderly.


Newer clinical and laboratory studies in the aged.  XIII.  General management of normal individuals after the age of 80.


Nutrition in preventive geriatrics.

Nutrition in preventive geriatrics.


Seven-year observations on the treatment of arthritis with hesperidin-ascorbic acid.


Problems of geriatric care.

Problems of geriatric care.


Massive prednisone and prednisolone therapy in leukemia and lymphomas in the adult.


Management of foot lesions in the elderly diabetic.


Rheumatoid arthritis complicated by severe ulcerative colitis, successfully treated with prednisone and Rauwolfia:  a case history.


Electrophoretic serum protein patterns in the aged.


Host-tumor antagonism.  I.  Evidence for the existence of tumor immunity.


Nurse-patient relationships.

Nurse-patient relationships.


Mortality among the married.

Mortality among the married.


Care of the terminal cancer patient.

Care of the terminal cancer patient.


Morbidity and mortality in old age; a study of experience in a modern home for the aged.  II.


Asthma; objectives of treatment and their attainment.


Risk of surgery in poliomyelitis patients dependent on respirators.


The community and rehabilitation of the hospitalized psychiatric patient.


Care of the bladder in neurological disorders.


Analysis of one hundred twenty consecutive cases of major arterial grafts.


Features of gerontology's clinical future.


Fifty-one cases of lung cancer with five-year survival.


The team approach to hearing and speech disorders.


Incomplete infarction of ileum simulating regional enteritis.


New vascular clamp without handles for lateral resection of aortic aneurysms.


Kartagener's syndrome in a newborn infant.


Significance of idiopathic venous thrombosis and hidden cancer.


Myleran in pregnancy; report of a case.

Myleran in pregnancy; report of a case.


NEW AND nonofficial remedies.

NEW AND nonofficial remedies.


Treatment of early mammary cancer.

Treatment of early mammary cancer.


Guiding principles of medical examinations in industry.


Tuberculosis and pregnancy.

Tuberculosis and pregnancy.


Occupational stress and emotional illness.


Use of meprobamate (Miltown) in convulsive and related disorders.


Chronic localized pulmonary brucellosis.


Causes and prevention of developmental defects.


Use of hexamethonium and dibenzyline in diagnosis and treatment of causalgia.


Explorations in testing drugs affecting physical and mental activity; studies with a new drug of potential value in psychiatric illness.


Effect of the Dock cigarette-smoking test on the ballistocardiogram; survey of a normal male population.


Mass screening techniques for cancer of the cervix.


Methallenestril, a new synthetic estrogen.


Can mass x-ray surveys be used in detection of early cancer of the breast?


Current status of West German medical schools.


Gallbladder disease in the aged.

Gallbladder disease in the aged.


Blood replacement in thoracic surgery for children.


Viral pneumonias.

Viral pneumonias.


Newer roentgenographic techniques in the diagnosis of retroperitoneal tumors.


New technique for treatment of mallet fingers and fractures of distal phalanx.


Hereditary leptocytosis (thalassemia minor).


Cancer of the colon and rectum; statistical study, with end-results.


Circulatory responses during anesthesia of patients on Rauwolfia therapy.


Vitamin K1 in treatment of bishydroxycoumarin-induced hypoprothrombinemia; comparison of intravenous and intramuscular administration.


A clinical review of pulmonary microlithiasis.


Meningeal diverticula of sacral nerve roots (perineurial cysts).


Hypervitaminosis A; report of a case in an adult.


An emergency set to combat anaphylaxis.

An emergency set to combat anaphylaxis.


Sigmund Freud.

Sigmund Freud.


The responsibility of the graduate educator in neurology and psychiatry.


Management of the frozen shoulder.

Management of the frozen shoulder.


Identification of malignant potentialities of melanocytic (pigmented) nevus.


High-speed cineradiography and electrocardiography; a new method for the study of heart disease in humans.


Hypertension associated with pregnancy; incidence and treatment, with particular reference to protoveratrine.


Physical and physiological clues for diagnosing eczema.


Coagulation defects in severe intrapartum and postpartum hemorrhage.


Induced hypotension as an aid to intracranial surgery.


Habilitation of the child with spina bifida and myelomeningocele.


Ocular toxicity of whipcide (3-methyl-1-pentyn-3-yl acid phthalate) in humans.


The search for a nonaddicting analgesic.


Congenital anomalies due to attempted abortion with 4-aminopteroglutamic acid.


Acute, subacute, and chronic subdural hematoma.


Progress in preventive medicine.

Progress in preventive medicine.


Preventive aspect of role of medicine in industry.


Preventive medicine in agriculture.

Preventive medicine in agriculture.


Current preventive problems of child health.


Newer concepts in chronic diseases.

Newer concepts in chronic diseases.


Impact of modern therapy on tuberculosis.


Health as an instrument of international policy.


Iatrogenic heatstroke.

Iatrogenic heatstroke.


Determination of radioiodine uptake in thyroids by two methods.


Anaphylaxis to heparin sodium; report of a case, with immunologic studies.


Corticotropin (ACTH) gel in treatment of irradiation enterocolitis; report of two cases.


ANTIVENIN (crotalidae) polyvalent.

ANTIVENIN (crotalidae) polyvalent.


METHYPRYLON.

METHYPRYLON.


PYRATHIAZINE hydrochloride.

PYRATHIAZINE hydrochloride.


PYRIMETHAMINE.

PYRIMETHAMINE.


INTRAMUSCULAR use of dimenhydrinate for postoperative nausea and vomiting.


SURVEY of group practice; preliminary report.


Pathogenesis of tuberculosis.

Pathogenesis of tuberculosis.


Anomalies of the aortic arches causing strangulation of the esophagus and trachea; a case report; surgical correction in a dog.


Persistent right aortic arch in a calf.

Persistent right aortic arch in a calf.


Hermann Boerhaave and Samuel Johnson.

Hermann Boerhaave and Samuel Johnson.


Treatment of fractures of the long bones in large animals.


Fracture of the fibula in the horse.

Fracture of the fibula in the horse.


Studies on therapy of swine enteritis.  I.  The effect of SMP-1 on experimental salmonellosis.


A whey-plate test for the diagnosis of bovine brucellosis.


A survey of gastrointestinal parasites of cattle of South Carolina.


Cardiac anomaly in a dog.

Cardiac anomaly in a dog.


Studies on therapy of swine enteritis.  II.  The effect of SMP-1 on transmissible gastroenteritis of swine.


Studies on swine enteritis.  III.  The effect of SMP-1 and other drugs on swine dysentery.


POSTVACCINATION abscesses.

POSTVACCINATION abscesses.


Metastatic micrococcic infection (botryomycosis) in a cat.


Internal fracture fixation in dogs and cats.


Veterinary science, its influence on people and progress.


The control of chronic calf pneumonia.

The control of chronic calf pneumonia.


Canine and feline spinal osteoarthritis (spondylitis deformans).


The use of malathion on cats and birds.

The use of malathion on cats and birds.


Swine enteritis.  II.  Terramycin levels in sow's milk following intramuscular and oral administration.


The recovery of Clostridium hemolyticum from the livers and kidneys of apparently normal cattle.


Fibrochondro-osteosarcoma of the humerus of a dog.


Necrotic vulvitis in feedlot heifers.

Necrotic vulvitis in feedlot heifers.


Onion poisoning in cattle.

Onion poisoning in cattle.


Dental examination of show steers.

Dental examination of show steers.


Isolation of Newcastle disease virus from man with confirmation by electron microscopy.


Monieziosis in a Wisconsin lamb.

Monieziosis in a Wisconsin lamb.


Effect of hypoxia on shivering.

Effect of hypoxia on shivering.


Mechanics of glossopharyngeal breathing.


A plastic balloon for recording intraesophageal pressures.


Oscillation mechanics of lungs and chest in man.


Metabolic cost of shivering.

Metabolic cost of shivering.


A manual method for artificial respiration for the simultaneous resuscitation of two victims.


Lactic and alactic oxygen consumption in moderate exercise of graded intensity.


Output of NaCl by sweat glands and kidneys in relation to dehydration and to salt depletion.


Survival after renal ischemia in dogs.

Survival after renal ischemia in dogs.


Effects of dehydration, salt depletion and pitressin on sweat rate and urine flow.


Effect of pain on simultaneous perception of nonpainful sensory stimulation.


Relation between uropepsin excretion and secretion of gastric juice.


Central and peripheral nervous effects of atropine sulfate and mepiperphenidol bromide (darstine) on human subjects.


Action of bioflavonoids on inflammation.


Blood volume, body water and body fat of the horse.


Turnover of gamma globulin in a patient with agammaglobulinemia as measured by radioiodinated human gamma globulin.


Physiologic chloride level of the saliva.


Stress adaptation and inhibition of restraint-induced (emotional) hypothermia.


Indirect determination of systolic and diastolic pressures in the rat.


An operant conditioning technique for studying feeding-fasting patterns in normal and obese mice.


A bloodless thermal recording digital flowmeter.


Relative tonicity of cellular and extracellular fluid in vivo.


Quantitative studies on influenza virus infection of the chick embryo by the amniotic route.


Effect of the buffer on the response of Streptococcus faecalis to purine bases.


Alterations in the nitrogen excretion pattern of chicks infected with Salmonella pullorum.


Shigella boydii serotypes in Egypt.

Shigella boydii serotypes in Egypt.


Studies of a bacteriophage active against a chromogenic Neisseria.


Enhancement of virulence of Malleomyces pseudomallei.


Electron microscopic study of phagocytosis of Staphylococcus by human leukocytes.


Hexitol metabolism in Escherichia coli.

Hexitol metabolism in Escherichia coli.


Physical methods for obtaining synchronous culture of Escherichia coli.


The oxidation of compounds related to the tricarboxylic acid cycle by whole cells and enzyme preparations of Mycobacterium tuberculosis var. hominis.


Succinic acid decarboxylation system in Propionibacterium pentosaceum and Veillonella gazogenes.  I.  Activation, decarboxylation, and related reactions.


Succinic acid decarboxylation system in Propionibacterium pentosaceum and Veillonella gazogenes.  II.  Evidence for an active C1 complex.


Factors influencing utilization of the stereoisomers of homocystine by Brucella.


The effect of x-rays on the survival of bacteria and yeast.  I.  A comparative study of the dose-survival curves of Azotobacter agile, Escherichia coli, Pseudomonas fluorescens, Rhodopseudomonas spheroides, and Saccharomyces cerevisiae irradiated in the resting state.


Dark reactivation in ultraviolet irradiated Escherichia coli.


Morphological and physiological considerations of colonial variants of Pseudomonas aeruginosa.


Resazurin staining of bacterial colonies on membrane filters.


The preservation of bacteria by freezing in glycerol broth.


Sonic oscillation as an aid in the counting of group A streptococci by the pour-plate method.


The x-ray picture of swelling of the capsule of the knee joint.


Some aspects of the use of fission product caesium 137 in telecurie units.


Localized spondylarthrosis after cholecystectomy.


Horizontal body section radiography as an aid in the diagnosis of diseases of the heart.


A safe for radioactive material permitting easy supervision.


Bismuth-206, a pure gamma-emitter for therapy.


Substrate specificity of enzymes reducing the 11- and 20-keto groups of steroids.


Rôle of vitamin B12 in nucleic acid metabolism.  III.  Preparation of C14 uniformly labeled pyrimidine deoxynucleosides.


Rôle of vitamin B12 in nucleic acid metabolism.  IV.  Metabolism of C14-labeled thymidine by Lactobacillus leichmannii.


Cholesterol metabolism in the dog.

Cholesterol metabolism in the dog.


A monophosphoinositide of liver.

A monophosphoinositide of liver.


Effect of progesterone on mitochondrial adenosinetriphosphatase.


Effect of progesterone on oxidative phosphorylation.


The determination of menadione and methods for the identification of quinones.


Studies on the reaction of menadione with blood and denatured proteins.


The determination of glycogen in liver and muscle by use of anthrone reagent.


Studies on the formation of oxalic acid by Aspergillus niger.


Liver catalase.  III.  Isolation of catalase from mitochondrial fractions of polyvinylpyrrolidonesucrose homogenates.


Studies on carbohydrate metabolism in rat liver slices.  VII.  Evaluation of the Embden-Meyerhof and phosphogluconate oxidation pathways.


Utilization of thymidine-C14 by bone marrow cells and isolated thymus nuclei.


Studies of deoxyribonucleic acid biosynthesis in embryonic tissues with thymidine-C14.


Conversion of uracil deoxyriboside to thymidine of deoxyribonucleic acid.


Distribution of lipides in the cerebellar cortex and its subjacent white matter.


Microdetermination of phospholipides and sphingolipides in brain.


The reaction of ninhydrin with dipeptides:  differences in reaction rates and theoretical yields.


The microdetermination of formate produced from pyruvate by cell-free extracts of Escherichia coli.


Studies on the in vitro perfusion of steroids through the dog kidney.


Nucleotide metabolism.  V.  Incorporation of P32 into acid-soluble nucleotides of rat liver in vivo.


The metabolism of the amidine group of arginine in the intact rat.


Measurement of the rate of fat absorption.


The metabolism of iron by rat liver slices; the effect of physical environment and iron concentration.


The metabolism of iron by rat liver slices; the effect of chemical agents.


On the biosynthesis of carotenoids.

On the biosynthesis of carotenoids.


Studies on the purification and properties of the serine-forming enzyme system.


Enzymatic and non-enzymatic dehydrochlorination of beta-chloro-L-alanine.


Purification and properties of serine and threonine dehydrases.


Studies on amylase synthesis by pigeon pancreas slices.


Isolation and properties of a reduced diphosphopyridine nucleotide derivative.


Enzymatic conversion of a reduced diphosphopyridine nucleotide derivative to reduced diphosphopyridine nucleotide.


The action of insulin in sparing fatty acid oxidation:  a study with palmitic acid-1-C14 and octanoate-1-C14.


Effect of coenzyme A on acetate activation.


A modified method for protein separation by zone electrophoresis on a starch gel.


The synthesis of arginine from guanidoacetic acid.


The quantitative histochemistry of the retina.


The creatine phosphoferase of a visceral muscle.


Fatty acids from the lipides of non-virulent strains of the tubercle bacillus.


Hemoglobin synthesis in rabbit reticulocytes in vitro.


The interaction between actomyosin and adenosine triphosphate, light scattering studies.


A study of the metabolism of purine riboside.


The chromatography of growth hormone on cellulose derivatives.


Identification of D-homosteroids in extracts of human urine.


Reactions of xanthydrol.  IV.  Determination of tryptophan in blood plasma and in proteins.


A cytochrome peroxidase from Pseudomonas fluorescens.


Effects of oxygen, iron, and molybdenum on routes of electron transfer in Pseudomonas fluorescens.


An electron microscope study of spermatid differentiation in the toad, Bufo arenarum Hensel. The differentiation of the spermatids of Bufo arenarum has been described from a study of electron micrographs of thin sections of testis. The development of the acrosome from the Golgi complex takes place in much the same manner as in mammalian spermatogenesis but no acrosome granule is formed. A perforatorium is described for the first time in this species. It is formed by a convergence of dense filaments that arise between the nuclear membrane and the head cap. During maturation of the spermatid the chromatin undergoes striking physicochemical alterations. Fine chromatin granules uniformly dispersed in the karyoplasm are replaced by larger and larger aggregates and these ultimately coalesce to form a very dense sperm head. Two centrioles of cylindrical form are situated very near the base of the sperm head. The longitudinal fibrils of the tail flagellum take origin from one, and the dense fibrous substance of the undulating membrane is closely related to the other. Phase contrast cinematographic observations on the swimming movements of living toad sperm, when considered in relation to the fine structural components of the tail, suggest that there is a contractile component in the undulating membrane as well as in the axial fibrils. The differences in the structure of mammalian and amphibian sperm tails are discussed in relation to differences in the character of their movements.


The ultrastructure of mouse lung; general architecture of capillary and alveolar walls. The general architecture of capillary and alveolar walls of the mouse lung was studied by means of the electron microscope. In order to minimize tissue damage and to improve the cutting properties of embeddings, several modifications in the tissue processing methods were adopted. These modifications were: fixation by infusion, a prolonged time of dehydration, of impregnation, and of polymerization, the use of acetone for dehydration, ammonium sulfide treatment of the fixed and washed tissue, and an elevated (80 degrees C.) polymerization temperature combined with the use of prepolymerized methacrylate. The generally favorable effects of these modified methods upon preservation and cutting properties of embedded tissue are discussed. Both capillary endothelium and alveolar epithelium were found continuous and without pores. The endothelium was seen to be thinnest in those portions that were adjacent to alveolar air spaces. Two morphological "types" of alveolar epithelial cells were found. One protruded into the alveolar lumen with its thick portion containing the nucleus. The other was often located in a niche of the alveolar wall, and contained peculiar dark inclusions amidst numerous mitochondria. Both were attenuated at their periphery to form the thin epithelial layer. The layer between endothelium and epithelium was designated as basement membrane. It was seen to be generally thin and structureless, but was found thickened in some areas where it also contained collagen fibrils.


An electron microscope study of the epithelium in the normal mature and immature mouse cornea. 1. An electron microscope study at high resolution of the corneal epithelium of the normal mature and immature mouse revealed new information regarding the submicroscopic appearance of these cells. 2. Two thin dense lines separated by a less dense area constituted the structure of the limiting surface membrane of epithelial cells; the thickness of this membrane was about 80 A. 3. Some differences in the appearance of the cytoplasm and mitochondria of cells from the immature mouse cornea and the appearance of the cytoplasm and mitochondria of cells from the adult mouse cornea were observed. 4. The basement membrane appeared as a dense band about 600 A wide separating the basal epithelial cells from the substantia propria. Suggestions of periodicity were seen in some phosphotungstic acid-treated specimens. 5. Round bodies believed to be bacteria were seen on the surface of the outer epithelial cells in the adult mouse cornea but not in the immature, unopened eye.


Morphological and cytochemical identification of the Golgi apparatus. 1. A modification of Elftman's direct silver method reveals both the lipochondria of Baker and the network of Golgi in the same cell. For purpose of distinction, it is proposed to call Baker's lipochondria the nucleopetal fraction, the Golgi network the nucleofugal fraction of the Golgi apparatus. 2. The nucleopetal fraction is located closer to the nucleus. It is spherical in shape and appears black in color. The nucleofugal fraction is located farther away from the nucleus. It is reticular in form and appears brown in color after silver impregnation by the modified Elftman's method. 3. These two fractions are separate entities. The network of Golgi is not due to deposition of silver on lipochondria. Lipochondria do not represent Golgi apparatus in living cells. 4. Aldehydes facilitate the demonstration of the nucleofugal fraction. Based on the circumstantial evidence presented, it appears that aldehyde dehydrogenase composed of a specific protein bound to a prosthetic group of flavin-adenine dinucleotide may be concentrated in this fraction. 5. Aldehyde dehydrogenase also functions as xanthine oxidase. It is suggested as a working hypothesis that under physiological condition, one of the functions of the nucleofugal fraction (Golgi network) is concerned with purine metabolism of nucleoproteins.


Electron microscopy of growing oocytes of Rana pipiens. 1. In the cytoplasm of oocytes of stage Y(0), prior to the appearance of yolk, one observes a few scattered profiles of endoplasmic reticulum and numerous filamentous mitochondria, usually distributed at random but sometimes clustered. As the nuclear membrane begins to bulge outward, small granules and short rods appear in the perinuclear cytoplasm and endoplasmic reticulum becomes more prominent throughout the cytoplasm. 2. Coincident with the appearance of the first yolk platelets, which are deposited in a narrow peripheral ring within the endoplasm at stage Y(1), protoplasmic processes, the microvilli, push out all over the surface of the oocyte. At the same time follicle cells pull away but remain attached to the oocyte at some points through finger-like processes which interdigitate with neighboring microvilli. It is estimated that the microvilli increase the absorptive area of the surface to about thirty-five times that of a simple sphere. Just beneath the microvillous layer is the basal protoplasm of the cortex, now containing tiny granules probably synthesized from newly absorbed raw materials. Cortical granules appear and become aligned below the basal layer on the external border of the endoplasm. Both the cortical granules and the yolk platelets measure up to 1 micro in diameter at this stage. 3. By stage Y(3) (yolk filling peripheral three-fourths of cytoplasm), the basal layer of the cortex is folded so that it appears in section as alternating ridges and valleys. The microvilli now extend from the summits of the cortical ridges. Small, ring-shaped granules are abundant in the cortex. Cortical granules have increased to 2 micro in diameter. 4. Yolk platelets continue to be synthesized around the cortical granules and in the subjacent endoplasm. The largest platelets measured in the interior cytoplasm at stage Y(4) (cytoplasm filled with yolk) were 3.7 micro wide by 5.8 micro long. Pigment granules increase in size from 0.15 micro in diameter at stage Y(3) to 0.30 micro in diameter at stage Y(4).


The structure of insect virus particles. THIN SECTIONS HAVE BEEN CUT OF THE VIRUS PARTICLES FROM FOUR TYPES OF INSECT VIRUS DISEASES: cytoplasmic polyhedroses of lepidopterous larvae, a nuclear polyhedrosis of Tipula paludosa (Diptera), a granulosis from Melanchra persicariae (Lepidoptera), and a new virus disease without polyhedra from T. paludosa. The cytoplasmic polyhedral viruses are thought to have composite particles in some cases. The shape and enveloping membranes of the different virus particles are compared. In the new virus disease of T. paludosa some of the virus particles appear to be empty; inclusion bodies surrounded by complicated membranes are also demonstrated.


Oxidative phosphorylation in mitochondria from livers showing cloudy swelling. Using succinate and alpha-ketoglutarate as substrates, oxidative phosphorylation has been measured in mitochondria isolated from livers showing cloudy swelling. This cellular change was obtained by injecting rats with S. typhi murium toxin and guinea pigs with diphtheria toxin. It has been found that phosphorylation associated with the oxidation of either of these substrates was partially inhibited in mitochondria from livers showing cloudy swelling, while the oxygen consumption was unchanged. Thus, the P:O ratios for both succinate and alpha-ketoglutarate were lower in mitochondria from treated animals than they were in normal mitochondria. Dephosphorylation of ATP was not significantly modified in mitochondria from livers showing cloudy swelling as compared with normal controls. No dephosphorylation of AMP and G-6-P was observed either in normal mitochondria or in mitochondria from treated animals.


Electron microscope observations on synaptic vesicles in synapses of the retinal rods and cones. The submicroscopic organization of the rod and cone synapses of the albino rabbit has been investigated with the use of the electron microscope. The most common rod synapse consists of an enlarged expansion of the rod fiber (the so called spherule) into which the dendritic postsynaptic fiber of the bipolar cell penetrates and digitates. The membrane surrounding the terminal consists of a double layer, the external of which is interpreted as belonging to the intervening glial cells. The synaptic membrane has a pre- and a postsynaptic layer with a total thickness of 180 to 300 A. The presynaptic layer is frequently denser and is intimately associated with the adjacent synaptic vesicles. The synaptic membrane shows processes constituted by foldings of the presynaptic layer. The entire spherule is filled with synaptic vesicles varying in diameter between 200 and 650 A with a mean of 386 A. In addition, the spherule contains a few large vacuoles near the rod fiber, interpreted as endoplasmic reticulum, and a matrix in which with high resolution a fine filamentous material can be observed. The postsynaptic fiber is homogeneous and usually does not show synaptic vesicles. In animals maintained in complete darkness for 24 hours vesicles appear to accumulate near the synaptic membrane and its processes. After 9 days there is a sharp decrease in size of the synaptic vesicles. A special rod synapse in which the dendritic postsynaptic expansion penetrates directly into the rod cell body has been identified. In line with Cajal's classification this type of synapse could be considered as a somatodendritic one. The cone synapse has a much larger terminal with a more complex relationship with the postsynaptic fiber. However, the same components recognized in the rod synapse can be observed. In animals maintained for 9 days in complete darkness there is also a considerable diminution in size of the synaptic vesicles.


Sedimentation studies of epidermal keratins:  keratin A and keratin B. Electrophoretically homogeneous keratin A and keratin B were studied in the ultracentrifuge. Both preparations revealed two fractions: one which sedimented rapidly and another which sedimented slowly. This indicated that both preparations are heterogeneous with respect to particle size.


Electron microscope observations on the submicroscopic organization of the retinal rods. The submicroscopic organization of the retinal rods of the rabbit has been studied with high resolution electron microscopy in thin longitudinal and cross-sections. The outer rod segment consists of a stack of flattened sacs or cisternae each of them limited by a thin homogeneous membrane of about 30 A. The membrane of the rod sacs is attached to the surface membrane and is also in continuity with short tubular stalks of about 100 to 150 A which apparently end in relation with the connecting cilium. The bundle of filaments that constitute the connection between the outer and the inner segments is described under the name of connecting cilium. This fibrous component has a structure that is very similar to that of the cilium. It shows 9 pairs of peripheral filaments of about 160 A in diameter, a matrix material, and a surface membrane. Very infrequently two central single filaments are observed. The connecting cilium has a typical basal body in the inner segment; its distal end penetrates the outer segment, where it establishes some structural relation to the rod sacs. The relationships and submicroscopic organization of the connecting cilium were studied in longitudinal and in cross-sections passing at different levels of the rod segments. The inner rod segment shows two distinct regions: a distal and a proximal one. The distal region, corresponding to the ellipsoid of classical histology is mainly composed of longitudinally packed mitochondria. It also contains the basal body of the cilium, vacuoles of the endoplasmic reticulum, dense particles, and intervening matrix with very fine filaments. In the proximal region of the inner segment the mitochondria are lacking and within the matrix it is possible to recognize elements of the Golgi complex, vacuoles of the endoplasmic reticulum, dense particles and numerous neuroprotofibrils of 160 to 200 A in diameter which collect and form a definite bundle at the exit of the rod fiber. The interpretation of the connecting fibers as a portion of a cilium and of the outer segment as a differentiation of the distal part of a primitive cilium are discussed. The importance of the continuity of the surface membranes of the outer segment, connecting cilium, and inner segment is emphasized and its possible physiological role is discussed.


Alterations in biochemical composition and ribonucleic acid metabolism induced in rat liver by cortisone. An investigation of the effect of cortisone administration upon the chemical composition of intracellular particulates of rat liver has been made. Livers were homogenized in 0.25 M sucrose solutions and submitted to differential centrifugation. Five fractions were prepared: mitochondria (Mit), microsomes (Mi), ultracentrifugable (U), non-sedimentable (S), and nuclear (Nuc). Measurement was made of total and polymerized RNA, nitrogen, lipide P, and uptake of P(32) by the RNA of each fraction. The following observations were made:- Cortisone administration caused a fall in concentration in all measured constituents except glycogen. On a per liver basis, however, total liver RNA was unchanged in amount; nitrogen content of Mi fell and that of S increased; the lipide P of Mit and Mi also decreased. The biochemical composition of a statistical mitochondrion was significantly altered; in contrast, the microsomal fraction decreased in amount, but the relationship between the chemical constituents was unchanged. When polymerized RNA was sought by a process involving precipitation from ethanol at 20 degrees C., none was found in the Mit of cortisone livers and the amount in Mi was much less than found in the normal. When, however, precipitation was conducted at 4 degrees C., yields of polymerized RNA in all fractions after cortisone were equal to or greater than those found in the normal. Furthermore, incubation of mixtures of homogenates from normal and cortisone livers resulted in loss of warm precipitable RNA. These data strongly suggest the presence of an enzyme in cortisone livers which upon incubation with normal livers made preparation of polymerized RNA virtually impossible by use of the warm method. This agent, thought to operate in vivo and in vitro, was not present in significant amounts in normal livers, since incubation in this instance had no effect upon the amount of polymerized RNA. Mit from cortisone livers obtained by the cold technique had a significantly decreased rate of incorporation of P(32) even though the yield of RNA from this fraction was increased. To reconcile these observations, it was proposed that under the influence of cortisone a variant of normal RNA is synthesized or normal RNA is converted to this variant. This "new" RNA has new solubility properties, a new rate of incorporation of P(32), and conceivably it cannot act as a template for normal protein synthesis.


The structure of collagen molecules and fibrils.


Avascular necrosis involving articular surfaces.


Legg-Perthes disease; observations on pathological changes in two cases.


Soft-tissue neoplasms associated with congenital neurofibromatosis.


Transposition of the tibialis anterior in the treatment of paralytic talipes calcaneus.


Some applications of the functional anatomy of the ankle joint.


Procedure to reduce dislocation of the shoulder.


Fractures of the proximal tibial epiphyseal cartilage.


Metaphyseal fibrous defects.

Metaphyseal fibrous defects.


The influence of splenectomy on the induction of osteogenic sarcoma in rabbits.


Benign chondroblastoma.

Benign chondroblastoma.


Stress tolerance of bone and metal.

Stress tolerance of bone and metal.


Osteochondritis dissecans of the ankle joint; report of a case simulating a fracture of the talus.


Fat embolism; the prophylactic value of a tourniquet.


Sterilization of preserved bone grafts by high-voltage cathode irradiation.


Functional bracing of the arm.  II.

Functional bracing of the arm.  II.


The status Bonnevie-Ullrich; case presentation.


Recurrent anterior superior dislocation of the glenohumeral joint.


A diagnostic reference file for orthopaedic surgery utilizing a punch card.


Coxa plana in dizygotic male twins.

Coxa plana in dizygotic male twins.


A postoperative arm-suspension sling.

A postoperative arm-suspension sling.


A simple method for elastic splinting of the thumb web.


Orthopaedic surgery in Australia.

Orthopaedic surgery in Australia.


Surgical treatment of the Klippel-Feil syndrome.


Treatment of infantile idiopathic scoliosis.


Treatment of osteoarthritis of the hip by osteotomy.


Multiple epiphysial dysplasia.

Multiple epiphysial dysplasia.


A muscle-tendon transposition for paralysis of the lateral abdominal muscles in poliomyelitis.


The results of lumbo-sacral fusion for low back pain.


Pseudocoxalgia; a study of late results in the adult.


The value of rigid fixation in the treatment of fractures of the adult tibial shaft.


The anterior tibial syndrome.

The anterior tibial syndrome.


Vascular complications of shoulder injuries; a report of two cases.


Alkaptonuric arthritis.

Alkaptonuric arthritis.


Familial infantile coxa vara.

Familial infantile coxa vara.


Solitary eosinophilic granuloma of bone.


Congenital discoid medial semilunar cartilage.


Posterior dislocation of both shoulders; report of a case.


ALBIN LAMBOTTE, 1866-1955.

ALBIN LAMBOTTE, 1866-1955.


Wear and tear in joints; an experimental study.


ARTHUR VINCENT MEEHAN, 1890-1955.

ARTHUR VINCENT MEEHAN, 1890-1955.


ANDREW RUSSELL MURRAY, 1910-1955.

ANDREW RUSSELL MURRAY, 1910-1955.


WILLIAM MACKENZIE, 1878-1955.

WILLIAM MACKENZIE, 1878-1955.


SYMPOSIUM on structure of enzymes and proteins given at Research Conference for Biology and Medicine of the Atomic Energy Commission sponsored by the Biology Division, Oak Ridge National Laboratory, Gatlinburg, Tennessee April 4-6, 1955.


The heterogeneity of serum globulins.

The heterogeneity of serum globulins.


The nature of the protein molecule:  problems of protein structure.


Microheterogeneity of protein molecules.


The biosynthesis of peptides and proteins.


Nucleoproteins; round-table discussion.

Nucleoproteins; round-table discussion.


Mechanism of incorporation of labeled amino acids into protein.


Structural factors in protein denaturation.


The effect of optical configuration of amino acid residues on the physical properties of peptides.


Chemical studies on enzymes and other proteins.


Configurations of polypeptide chains and protein molecules.


Molecular geometry in enzyme action.

Molecular geometry in enzyme action.


Steric specificity of hydrogen transfer in pyridine nucleotide dehydrogenase reactions.


The active groups of pepsin.

The active groups of pepsin.


Kinetic effects of the ionization of groups in the enzyme molecule.


An outline of the essentials of treatment for pulmonary tuberculosis for the general practitioner.


Hypertension and pregnancy.

Hypertension and pregnancy.


Hypertension in pregnancy.

Hypertension in pregnancy.


New high density particles in certain normal and abnormal erythrocytes.


The effect of increased pressures of oxygen upon the luminescence of Achromobacter fischeri.


CO-OPERATION with the home; report of discussion group III.


On the reproducibility in the observed ultrastructure of the normal mammalian red cell plasma membrane.


SYMPOSIUM; pain and its relief.

SYMPOSIUM; pain and its relief.


Flicker in erythrocytes; vibratory movements in the cytoplasm.


Introductory statement on a symposium on pain and its relief.


The diffusion of glucose into the human red cell.


Current concepts of the pain process.

Current concepts of the pain process.


Differences between young and mature rabbit erythrocytes.


Limiting factors in experimental pain.

Limiting factors in experimental pain.


The adsorption of serum albumin by human erythrocytes.


The nature of pain.

The nature of pain.


Problems of experimental algesimetry and a comment on the tooth pulp method.


The search for new analgesics.

The search for new analgesics.


Postoperative pain:  research and treatment.


Control of pain in metastatic cancer.

Control of pain in metastatic cancer.


The anesthesiologist and the management of pain.


Addiction problems in the medical use of narcotic analgesics.


Effect of cortisone and adrenocorticotropin on the electroencephalogram of normal adults:  quantitative-frequency analyses.


The metabolism of iodotyrosines.  II.  The metabolism of mono- and diiodotyrosine in certain patients with familial goiter.


Excretion of epinephrine and norepinephrine after administration of insulin and methacholine.


The progestational activity of 17-alpha-ethinyl-19-nortestosterone.


Clinical experiences with carbimazole (1-methyl-2-carbethoxy-thio-imidazole) in the treatment of hyperthyroidism.


Serum antidiuretic activity in patients with neurosis and premenstrual tension.


Cyclical changes in female nasal mucus.

Cyclical changes in female nasal mucus.


The presence of 6-beta-hydroxylase in human placenta.


The question of a psychogenic factor in some cases of primary amenorrhea.


The effect of variations in solute excretion and glomerular filtration on water diuresis.


The interaction of glucagon and insulin on blood glucose.


Alterations in body composition with sodium loading and potassium restriction in the rat:  the total body sodium, nitrogen, magnesium and calcium.


The distribution of HG203-labeled mercaptomerin in human tissues.


Total body water and total exchangeable sodium in edematous states due to cardiac, renal or hepatic disease.


Physicochemical estimation of aldosterone in urine.


Thyroxine metabolism in the nephrotic syndrome.


Radiothyroxine turnover studies in myxedema, thyrotoxicosis, and hypermetabolism without endocrine disease.


Characterization of the proteins of human synovial fluid in certain disease states.


Comparison of liver blood flow values estimated by the bromsulphalein and by the radiogold method.


The mode of virus multiplication and the susceptibility of these agents to the antibiotics.


Neonatal diarrhoea due to Salmonella paratyphi B.


Antibiotic-resistant staphylococcal pseudomembraneous enteritis.


Renal sarcoidosis.

Renal sarcoidosis.


Aminoaciduria in the megaloblastic anaemias.


Bacteriophage typing of enteric pathogens and staphylococci and its use in epidemiology.


The blood pyruvic acid level in renal diseases and in uraemic coma.


Studies on urinary peptides isolated from patients suffering from burns.


Liver function tests in rheumatoid arthritis.


The urinary excretion of copper and its concentration in the blood of normal human adults.


The estimation of magnesium in serum using titan yellow.


The colorimetric estimation of 3-chlorpromazine in biological fluids.


The improved determination of iron in serum.


An apparatus for microdetermination of CO2 in plasma.


A preliminary communication on a conductrimetric screening test for electrolytes.


The estimation of peptidase activity in the white blood cells by paper chromatography.


Validation and intensification of the Sixteen Personality Factor Questionnaire.


Trait judgments from photographs as a projective device.


A modification of Sula's method for the cultivation of tubercle bacilli from pleural fluid.


Research in clinical psychology:  1955.

Research in clinical psychology:  1955.


Speech behavior and egocentricity.

Speech behavior and egocentricity.


Vocational tests as measures of performance of schizophrenics in two rehabilitation activities.


A study of the relationships between self-ratings and parent-ratings for a group of college students.


An experimental study of the effects of individual and group presentation of the Rorschach plates.


Spiral aftereffect as a test of organic brain damage.


The Rorschach as a physiological stress.


The Cornell Medical Index in a psychiatric outpatient clinic.


A quantitative method of scaling communication and interaction process.


Evaluative study of one hundred transorbital leucotomies.


Factors influencing utilization of psychotherapeutic services in male college students.


MMPI score changes induced by lysergic acid diethylamide (LSD-25).


Some factors associated with the visual threshold for taboo words.


The repeat reliability of clinical judgments of test responses.


Anxiety and goal-setting behavior.

Anxiety and goal-setting behavior.


Distraction and affective disturbance.

Distraction and affective disturbance.


Body-concept disturbances of patients with hemiplegia.


Personality correlates of duodenal ulcer and other psychosomatic reactions.


At the sign of the cult.

At the sign of the cult.


Nucleolar and Nissl substance development in nerve cells.


Regression or disintegration in schizophrenia?


The spino-bulbar tracts and the pelvic sensory vagus; further contributions to the theory of the sensory dual innervation of the viscera.


A microphotometric method of cell enumeration within the cerebral cortex of man.


An experimental study of the fornix system in the rat.


Localization and threshold studies of electrically-induced seizures in the salamander.


Resting and action potentials of cultured chick embryo spinal ganglion cells.


Imprinting:  the interaction of learned and innate behavior.  I.  Development and generalization.


Social interactions of Rhesus monkeys.  II.  Effects of social interaction on the learning of discrimination tasks.


An analysis of number-concept formation in the Rhesus monkey.


Effects of age and experience on play and exploration of young chimpanzees.


Learning sets in marmosets.

Learning sets in marmosets.


The formation of learning sets by cats.

The formation of learning sets by cats.


Variable delayed reinforcement.

Variable delayed reinforcement.


Training rats to press a bar to turn off shock.


The effect of prolonged exposure to visually presented patterns on learning to discriminate them.


The facilitation of visual and spatial discrimination reversal by overlearning.


The effect of varying conditions of hunger and thirst on two responses learned to hunger or thirst alone.


The effect of drive on learning with secondary reinforcement.


An experimental method of producing gastric ulcers.


Dimensions of discrimination and level of cholinesterase activity in the cerebral cortex of the rat.


Some individual differences in physiological reactivity to stress.


The relationship between environmental temperature and behavior in neonatal puppies.


A preliminary mapping of electrical reinforcing effects in the rat brain.


The effect of prefrontal lobotomy in Rhesus monkeys on delayed-response performance motivated by pain-shock.


The effect of phase manipulation upon electrocutaneous stimulation.


The effect of anoxia on the retention of a discrimination habit.


The compulsive nature of abnormal fixations.


Traumatic avoidance learning; the effects of CS-US interval with a delayed-conditioning procedure in a free-responding situation.


Effects of electroconvulsive shocks on maze relearning by albino rats.


Evaluation of laboratory tests for the estimation of caries activity.


A system of classification and scoring for prevalence surveys of periodontal disease.


The incidence of dental caries in adolescents with different occlusion.


Use of epoxy resins in restorative materials.


Measurement of the reducing activity of hetero- and homofermentative lactobacilli.


The reducing property of saliva toward several oxidation-reduction indicator dyes.


Titratable acidity and titratable alkalinity of the saliva of cases chosen with reference to dental caries.


A simple, rapid method for quantitative determination of salivary amylase.


The effects of penicillin and terramycin on dental caries and certain oral microflora in Hunt-Hoppert caries-susceptible rats.


Studies on the aciduric oral micrococci.


Influence of fluorides on the rate of dissolution of the principal inorganic elements of dentin.


The distribution of lead in human enamel.


The distribution of fluoride in human enamel.


Ammonia production in saliva.  II.

Ammonia production in saliva.  II.


The cultivation of tooth germs in an embryo extract-free medium.


Residual mercury content of amalgam restorations and its influence on compressive strength.


An investigation to determine the effects of starch sponge implanted in bone.


The effect of lymphocytic choriomeningitis on pregnancy and dental tissues in mice.


Tooth development and eruption.  II.  A biometric analysis of the histologic relationship of the root of the mandibular first molar of the rat in growth and eruption to the lower border of the mandible.


A modified Gallego's iron fuschin stain as a differential stain for cementum.


On the preservation of gross pathological specimens.


The acid-polysaccharide content of normal and atheromatous arteries.


Hernial repair by whole-skin graft; with report on 134 cases.


Cervical spina bifida occulta.

Cervical spina bifida occulta.


Glutamic acid in the treatment of cerebral arteriosclerosis and some cases of hypertension.


A new synthetic resin effective in the treatment of enterocolitis.


Sulphaemoglobinuria during the administration of antimony-III-pyrocatechin di-sulphonate of sodium.


On antibiotics in acute intestinal amoebiasis; aureomycin, terramycin, achromycin, erythromycin, neomycin and fumagillin.


B-nitrostyrene:  a snail and insect poison; a preliminary report.


Observations on the morphology of the anencephalic skull.


Observations on the movements of the human tongue.  II.


Researches on an antimicrobic and antiallergic drug.


Cystinuria and cystin stones description of a case with cystin stones.


A case of eosinophilic pulmonary infiltration.


Peptic dyspepsia due to chronic appendicular disease.


The evaluation of some miscellaneous compounds in the treatment of amoebiasis:  1-The antibiotic actibio; 2-Camoform; 3-Mercaptoarsenol; 4-Siosteran.


Effect of storage on sodiumantimony III bis pyrocatechin disulphonate of sodium.


Pharmacological action of Anagallis arvensis (Ain el Kot).


Tuberculous meningitis; pathology and classification.


A histopathological study of the minute vasculature of the peptic gastric ulcer.


Effect of 5-hydroxytryptamine (antemovis) as an antihemorrhagic in various cases of bleeding in gynaecology.


The pathogenesis of hyperlipemia induced by means of surface-active agents.  I.  Increased total body cholesterol in mice given triton WR 1339 parenterally. Mice rendered hyperlipemic by means of intravenous or subcutaneous injections of triton WR 1339 were found to have an increase in the total amount of cholesterol in their bodies. This observation indicates that the injected surface-active agent affects the metabolism of cholesterol and brings about hyperlipemia by augmenting the synthesis of lipides, or by interfering with their degradation or excretion, or by some combination of these factors. The implications of the findings for the pathogenesis of the hyperlipemia induced by triton are discussed further in the accompanying paper (16).


The pathogenesis of hyperlipemia induced by means of surface-active agents.  II.  Failure of exchange of cholesterol between the plasma and the liver in rabbits given triton WR 1339. Rabbits subjected to subtotal hepatectomy failed to develop increased serum cholesterol levels following parenteral injection of triton WR 1339, the finding indicating that the liver is essential for the establishment of the hypercholesterolemia induced by surface-active agents. The cholesterol content of the livers of rabbits rendered hyperlipemic by means of triton remained unchanged both during the rapid rise of the serum cholesterol levels and during the return to normal values. By contrast, the cholesterol content of the livers of rabbits fed cholesterol rose progressively over a period of 5 weeks, concommittant with the increase in serum cholesterol levels. The findings provide support for the hypothesis that surface-active agents bring about hyperlipemia by altering the circulating lipoproteins in some manner so that they are retained in the circulating body fluids.


Nature of fluids which functionally distend the kidney. The nature of the fluid draining from the kidney, after its artery was occluded, was investigated. Samples of systemic arterial blood, renal venous blood and urine were also analyzed. It was found that the fluid draining from the kidney after occlusion is a mixture of vascular blood and another fluid designated as "diluting fluid," each contributing half to the composite mixture. In volume the mixture is 26 per cent of the functionally distended kidney. With the assumption that the renal extracellular fluid can be considered a simple mixture of blood plasma and a cell-free fluid, the composition of the "diluting fluid" was deduced from the known compositions of vascular blood and total fluid draining. The ratios of its content in a given substance to that in systemic (or renal venous) plasma are: for Na and Ca, 1.0; K, 1.5; Cl, 1.2; PO(4), 2.0; urea, 1.8; plasma protein, 0.3; albumin, 0.4; glucose, 0.4, and osmolarity, 1.2. The fluid bears little or no relation to urine, especially since the urine varied considerably between individual dogs whereas the "diluting fluid" was relatively constant in composition. It was also found that the hematocrit of the fluid draining after arterial occlusion progressively decreased as it flowed out, until the last portion contained only 5 per cent red cells. It is concluded that since renal lymph has approximately the same composition in protein, urea, glucose, and inulin as does "diluting fluid," the latter is, in all probability, renal interstitial fluid. Under the conditions of the experiment, it drains out of the kidney slowly relative to blood drainage. It is large in volume, particularly when compared with the capillaries that nourish it. Its high protein content explains the observation that the kidney is apparently naturally distended with a fluid disproportionately rich in plasma protein.


Distribution of blood in the functional kidney. An attempt to measure the distribution of blood in the functional kidney of dogs was made. The method involved the injection of liquid latex rubber into the vascular system at physiologic pressures, fixation of the rubber in situ, and then, after corroding away all tissue, measurement of the volume of the rubber casts. The kidney contains, in its functionally distended state, 14 per cent blood. Of this, 4.5 per cent is apparently in the arteries and some 7 per cent in the veins. The functional engorgement of the cortical interlobular veins (about 4 per cent) is particularly striking, for they form a dense palisade of 40 to 300 micro vessels. These are not seen at the usual autopsy since they have drained out and collapsed. It is pointed out that attempts to describe the blood distribution in the kidney after it has been drained of blood are of dubious value. In the light of these data, also, the nature of the measurement of "intrarenal pressure," accomplished by inserting a needle into the renal parenchyma, may be better understood: it is suggested to be primarily a measure of interlobular venous pressure.


Reversible changes in the susceptibility of mice to bacterial infections.  I.  Changes brought about by injection of pertussis vaccine or of bacterial endotoxins. MICE WERE INJECTED INTRAPERITONEALLY WITH ONE OF THE FOLLOWING BACTERIAL PRODUCTS HAVING ENDOTOXIN ACTIVITY: pertussis vaccine, a suspension of heat-killed cells of Klebsiella pneumoniae (type C), or a purified lipopolysaccharide prepared from cultures of Salmonella typhosa. Following treatment with either one of these materials, the animals were infected intravenously with virulent cultures of coagulase-positive staphylococci, with bovine tubercle bacilli, or Friedländer bacilli. The effect of treatment with endotoxin materials on resistance to Friedländer bacilli, staphylococci, or tubercle bacilli was estimated by observing the mortality rates in infected animals, and by determining quantitatively the numbers of living bacteria in the organs at different periods of time after infection. It was found that mice receiving the infective dose of virulent culture a few hours after treatment with the endotoxin material, were usually more susceptible to infection than were untreated animals. In contrast, mice infected at a later period proved far more resistant to infection than did untreated animals. The duration of the negative and of the positive phase of resistance was affected by the amount of endotoxin injected. Marked increase in resistance of mice to infection with staphylococci or tubercle bacilli was still evident several weeks after treatment with pertussis vaccine or with purified lipopolysaccharide extracted from typhoid bacilli.


Reversible changes in the susceptibility of mice to bacterial infections.  II.  Changes brought about by nutritional disturbances. A study has been made of the time variations in the susceptibility of albino mice to experimental infections with Klebsiella pneumoniae, Staphylococcus aureus, and Mycobacterium tuberculosis. Susceptibility to infection was determined by two criteria: (a) mortality rates following intravenous injection of a known infective dose; (b) numbers of bacterial colonies that could be recovered from the tissues of the infected animals at various times after infection. When measured in terms of either one of these two criteria, susceptibility was consistently modified by temporary deprivation of food, and by various changes in the composition of the diet. Increase in susceptibility to infection could be detected within a few hours to a few days depending upon the nature and intensity of the nutritional disturbance imposed upon the animal. Under the proper conditions, return to a normal state of resistance could also occur within a very short time. There was commonly observed an explosive bacterial multiplication in mice receiving the infective dose shortly after being subjected to nutritional disturbances. In the case of infection with Klebsiella pneumoniae, however, this phase of increased susceptibility was often followed a few hours later by one during which the numbers of living bacteria that could be recovered from the various organs fell to a very low level. Many of the animals which had exhibited severe but transient bacteriemia recovered rapidly and survived the infection. Mice rendered more susceptible to infection by being fed deficient diets progressively recovered their normal resistance while being kept on the same inadequate regimens. This adaptation occurred even though the weight of the animals on these regimens remained much lower than the weight of the animals fed a complete diet ad lib. The weight of the animal at the time of infection appeared to have little bearing on susceptibility. However, susceptibility consistently increased during the periods while the animals were losing weight-whatever the cause of the weight loss. The facts disclosed in the present study, as well as findings reported by other investigators, make clear that profound changes in susceptibility to infection can be brought about by varied non-specific procedures. These changes can occur within very short periods of time and are often rapidly reversible.


Modification of the homotypic specificity of poliomyelitis complement-fixing antigens by heat. Fluid obtained from HeLa cell cultures infected with poliomyelitis viruses served as a complement-fixing antigen. When used in the native state, i.e. untreated in any way, the fluids acted as homotypically specific antigens. When heated, however, the antigenicity was broadened and a high degree of heterotypic reactivity was encountered. Data are presented indicating that the observed group reactivity was apparently based on common antigens shared by the three immunologic types of poliomyelitis virus. This reactivity appeared to be specific for the poliomyelitis viruses. No evidence was obtained in preliminary experiments that heating of the antigens releases a "soluble" antigen responsible for the group reactivity.


A serologic recapitulation of past experiences with influenza A; antibody response to monovalent vaccine. The results of the present study provide a striking demonstration of antibody orientation produced by the dominant antigens of the strains of influenza virus encountered at childhood. The homologous and heterologous antibody response to monovalent vaccines containing swine, PR8, FM1, or Cuppett viruses show that the antibody-forming mechanisms of children born after 1943 are oriented to strains of influenza A-prime; of recruits to strains of influenza A; and of persons over 30 years of age to a strain of swine influenza. It was shown that antibody response to heterotypic viruses appears to provide a serologic index of the amount of experience each of the segments of the general population studied have had with antigenic variants of influenza virus. Finally it was demonstrated that the antibody response of humans to strains of influenza A or influenza A-prime is remarkably uniform for isolates of each antigenic type.


Studies on the interaction between phagocytes and tubercle bacilli.  II.  The action of phagocytes upon C14-labelled tubercle bacilli. Tubercle bacilli labelled with C(14) were prepared by growth on radioactive substrates such as glycerol, CO(2), and acetate. These organisms were exposed in vitro to leucocytes (mostly polymorphonuclear leucocytes) from peritoneal exudates of guinea pigs. The respiration of the leucocytes and of the bacilli, alone and together, was followed by determining oxygen uptake and C(14)O(2) production. When heat-killed labelled tubercle bacilli were exposed to leucocytes there was little or no degradation of bacillary material to C(14)O(2) by leucocytic enzymes. On the other hand, conversion of components of sonically disrupted bacilli to C(14)O(2) by leucocytes was significant. It was possible to determine the oxygen uptake and C(14)O(2) production of phagocytized living tubercle bacilli, and it was found that after phagocytosis the bacilli maintained their rates of oxygen consumption and C(14)O(2) production. This finding was in contrast to observations made with Mycobacterium phlei, a saprophytic acid-fast organism, and with Bacillus subtilis. In these cases oxygen consumption and C(14)O(2) production declined after phagocytosis, and bacterial components were converted to carbon dioxide to a significant degree by leucocytic enzymes.


Studies on the interaction between phagocytes and tubercle bacilli.  I.  Observations on the metabolism of guinea pig leucocytes and the influence of phagocytosis. As a basis for studies on the interaction of phagocytes and tubercle bacilli experiments were carried out to obtain information on some biochemical characteristics of exudate leucocytes from guinea pigs. It was found that total cellular phosphorus was the most suitable measure of protoplasm. Cell counts were less reliable because of unavoidable clumping in the suspension, and dry weight measurements were less specific when contamination with erythrocytes occurred. The utility of phosphorus measurements in this connection depends upon the fact that an erythrocyte contains only 4 per cent of the phosphorus present in a leucocyte. From measurements on mixed suspensions consisting of varying known proportions of polymorphonuclear and mononuclear leucocytes as determined by differential counting, it was possible to compute true values for these two cell types with respect to oxygen consumption and lactic acid production. Thus it was found that monocytes consumed considerably more oxygen and produced more lactate than polymorphonuclear leucocytes. From the data obtained it is suggested that differences in metabolic activity found when comparing cell suspensions obtained by the use of different irritants are due to different proportions of the two cell types. In particular, the effects of oxygen tension and pH on the activities of the cells were studied. It was found that decreasing the proportion of oxygen in the atmosphere from that of air to 1 per cent reduced oxygen consumption by about 80 per cent, whereas lactic acid production was increased by about 45 per cent. It was also found that decreasing the pH of the medium below pH 7.5 caused a considerable reduction in the respiration, lactate production, and viability of polymorphonuclear leucocytes. The monocytes proved less sensitive to similar changes in pH, especially with regard to lactic acid production and viability. Observations were made of oxygen consumption and lactate production during phagocytosis. During the hour following the addition of heat-killed tubercle bacilli to the phagocytes, the oxygen consumption of suspensions rich in polymorphonuclear leucocytes rose by 60 per cent, and that of suspensions rich in monocytes rose by nearly 100 per cent. Lactic acid production was unchanged during phagocytosis.


Human escape learning in relation to reinforcement variables and intertrial conditions.


Effects of stress and anxiety on continuous high-speed color naming.


Analytical pathology.  IV.  The role of localized antibodies in the pathogenesis of nephrotoxic nephritis in the rat. The principal objective of this investigation was to define the roles of injected and autogenous, kidney-localizing antibodies in the pathogenesis of rat nephrotoxic nephritis by relating data obtained with fluorescent antibody techniques to clinical and histologic observations. Such an analysis of the nephritis that developed in 28 rats after injection with the crude gamma-globulin fraction of nephrotoxic serum has led us to the following conclusions:- The renal localization of nephrotoxic antibodies is primarily and, perhaps, exclusively in the membranes of the glomerular tufts. These antibodies are demonstrable, as antigens, in the glomeruli for up to 3 months after injection. In the acute stage of the nephritis, non-antibody, autogenous globulins are present in the glomerular tufts, probably as components of edema fluid. From 6 and 9 days to 3 months after injection, autogenous antibodies are localized in the glomerular tufts in a pattern that corresponds closely to that of the nephrotoxins. The essential requirements for the operation of the mechanism postulated by Kay are fulfilled in rat nephrotoxic nephritis.


Effects of stress on complex learning and performance.


Effect of different percentages of money reward on extinction of a lever-pulling response.


Anticipation of reward as a function of partial reinforcement.


An analysis of the effect of nonreinforced trials in terms of statistical learning theory.


Effect of overlearning of a verbal response on transfer of training.


Simultaneous and successive discrimination in a single-unit hollow-square maze.


A methodological study of the preparation of connected verbal stimuli for quantitative memory experiments.


Stimulus units and range of experienced stimuli as determinants of generalization; discrimination gradients.


Habit strength as a function of drive in a brightness discrimination problem.


Metacollagen as the apparent elastin.

Metacollagen as the apparent elastin.


Basement membranes, ground substance, and lymphocytic aggreates in aging organs.


Treatment of senescent male rats with cortisone acetate alone or together with sex and thyroid hormones.


Peritoneal fluid mast cells:  their numbers and morphology in rats of various body weights (ages).


Some biochemical aspects of aging in insects.


Hexosamine and acid-hydrolyzable sulfate concentrations of the aorta and pulmonary artery in individuals of various ages.


Neurohypophyseal responsiveness in the normal and senescent rat.


Observations on blood vessels and exercise.


Aging:  a theory based on free radical and radiation chemistry.


Geriatric office gynecology.

Geriatric office gynecology.


Problem solving set in different age groups.


An age difficulty in separating spatially contiguous data.


The effect of migration on the number and distribution of the aged in Florida.


The role of welfare agencies in providing services to the aged:  the role of the public agency.


The mechanism of the Marchi type of methods for visualizing degenerating myelin.  Model experiments with pure compounds.


The replacement of the acid hydrolysis of the Feulgen reaction by bromination.


The effect of mucolytic enzymes on tissues stained with the periodic acid-Schiff technique.


Histochemical demonstration of aminopeptidase.


Cytochemical studies of mitochondria in leptomonad form of Leishmania donovani, the kala-azar parasite.


Structural and chemical studies on the connective tissue of marine sponges.


A chemical-histochemical evaluation of acid phosphatase activity in human skin.


Histochemical localization of specific oxidative enzymes.  I.  Tetrazolium stains for diphosphopyridine nucleotide diaphorase and triphosphopyridine nucleotide diaphorase.


Histochemical localization of specific oxidative enzymes.  II.  Localization of diphosphopyridine nucleotide and triphosphopyridine nucleotide diaphorases and the succindehydrogenase system in the kidney.


Investigation of the tetanus toxin from two different strains of Clostridium tetani.


Histochemical localization of specific oxidative enzymes.  III.  Evaluation studies of tetrazolium staining methods for diphosphopyridine nucleotide diaphorase, triphosphopyridine nucleotide diaphorase and the succindehydrogenase system.


Inhibition of blood-group agglutinins by substances occurring in plants.


Studies on organ specificity.  IV.  Production of rabbit thyroid antibodies in the rabbit.


Kinetics of human complement.  II.  Separation of the reaction between human complement and sensitized cells into two steps.


A quantitative study of the passive Arthus reaction in the rabbit eye.


Studies on organ specificity.  V.  Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts.


Serologic relationship among meningococcal strains in Norway.


Non-specific viral inactivating substance (VIS) in human and mammalian sera; natural antagonists to the inactivator of Newcastle disease virus and observations on the nature of the union between the inactivator and virus.


Study on the growth of Rickettsiae.  I.  A tissue culture system for quantitative estimations of Rickettsia tsutsugamushi.


Infestation with ova morphologically resembling Schistosoma haematobium.


Use of vinyl plastic containers in tissue cultures for virus assays.


Decortication in clotted haemothorax.

Decortication in clotted haemothorax.


Histamine shock in adrenalectomised rats.


Cavernous sinus syndrome in pituitary tumours.


Pericarditis.

Pericarditis.


Emphysema and its problems.

Emphysema and its problems.


Two cases of erythroblastic babies of whom one was saved by exchange transfusion.


Fatal fat embolism following criminal violence.


A method of preparing a pedunculated flap with maximum vascularity and resistance to infection.


The artificial kidney.

The artificial kidney.


Hip fractures; present status of the problem.


WHAT AMERICANS think of the medical profession:  report of a survey.


Air embolism.

Air embolism.


Tuberculous peritonitis in a moribund patient; plication; recovery.


Duodenal ulcer:  end results in vagotomized patients.


Recent ideas in gastric surgery.

Recent ideas in gastric surgery.


Management of leg ulcers.

Management of leg ulcers.


PVP-iodine:  history, toxicity and therapeutic uses.


Pathogenesis and treatment of the idiopathic or primary hydronephroses.


Renal responses to remote surgical manipulations in the dog.


Complications of surgery of the genitourinary tract.


Lesions of the central nervous system masquerading as general surgical lesions.


Complications of pelvic surgery:  hemorrhage.


Obstetric and gynecologic problems in general practice.


Focal infections and their relation to the eye.


Technical problems in the surgical treatment of otosclerosis.


Tumors of the nose and paranasal sinuses.


Management of anal incontinence.

Management of anal incontinence.


A study of human epidermal proteins.

A study of human epidermal proteins.


Treatment of cheilitis exfoliativa of the lower lip with hyaluronidase; report of four cases.


Histochemical distribution of acid phosphatases in normal human skin.


The effect of carcinogenic agents on the phosphorus content of hair bulbs and epidermis:  the effect of x-rays on the phosphorus content of the hair bulbs.


The effect of the topical application of corticotrophin, hydrocortisone, and fluorocortisone on the process of cutaneous inflammation.


The action of x-ray irradiation and painting with carcenogenic hydrocarbons on the phosphorus content of the epidermis.


The use of detergents for direct mycologic examination.


V.D.R.L. chancroid studies.  I.  A simple procedure for the isolation and identification of Hemophilus ducreyi.


V.D.R.L. chancroid studies.  II.  Experimental chancroid in the rabbit.


V.D.R.L. chancroid studies.  III.  Use of Ducrey skin test vaccines on rabbits.


A synthetic detergent as a provocative agent in patch tests.


Early versus late ambulation in the treatment of cardiac patients.


Medicine in a changing world.

Medicine in a changing world.


Results of corneal transplants at the State University of Iowa.


New surgical approach to the relief of angina pectoris.


CLINICAL pathologic conference.

CLINICAL pathologic conference.


Some practical problems involved in an educational program on the care of premature infants.


Planning your new office.

Planning your new office.


Ophthalmology in the East.

Ophthalmology in the East.


Hospitals in a National Health Service.

Hospitals in a National Health Service.


The school medical service in a rural county.


Early clinical pictures in bronchogenic carcinoma.


Intravenous ergometrine given in a case of undiagnosed twins.


The acute abdomen.

The acute abdomen.


SUPERANNUATION of medical officers in the employment of local authorities.


Diabetes mellitus.

Diabetes mellitus.


The relationship of physical exertion to the onset of spontaneous pneumothorax.


Pulmonary collapse in general practice.

Pulmonary collapse in general practice.


Closed tendon rupture in the hand.

Closed tendon rupture in the hand.


Abscess in the falciform ligament.

Abscess in the falciform ligament.


Fractures of the malar-zygomatic compound.


Giardiasis:  Giardia (lamblia) intestinalis as a cause of gastro-intestinal disease.


The use of reserpine (serpasil) in psychiatry.


The second hurdle:  the conquest of pain.


Parathyroid adenoma.

Parathyroid adenoma.


Causation of mental disease.

Causation of mental disease.


Acute cerebro-vascular disorders; an analysis of 60 cases with special reference to the use of cervical sympathetic block.


Disseminated sclerosis following healed tuberculous meningitis.


Granuloma annulare.

Granuloma annulare.


Intermittent hydrocephalus following tuberculous meningitis; report of a case.


Abdominal injury.

Abdominal injury.


Transportation of injured.

Transportation of injured.


Emergency room care.

Emergency room care.


Lower extremity fractures.

Lower extremity fractures.


Burns.

Burns.


Ocular emergencies.

Ocular emergencies.


Head injuries.

Head injuries.


Tumor conference; islet cell tumors.

Tumor conference; islet cell tumors.


Spontaneous arterial thrombosis; development in the internal carotid artery.


Chlorpromazine in a state hospital.

Chlorpromazine in a state hospital.


Surgical treatment of lymphedema.

Surgical treatment of lymphedema.


A urologic perspective of abdominal tumors.


Evaluation of vagotomy and pyloroplasty in the treatment of duodenal ulcer.


Some effects of general anesthetic agents on the heart.


The residual tuberculous disease after chemotherapy.


The effects of cortisone on the fructose and glucose tolerance tests of normal men.


Observations on a presumptive case of primary aldosteronism.


The rate of intravascular equilibration of intravenously administered I131-labeled albumin in various body sites.


Human serum lipoproteins.  I.  Chemical composition of four fractions.


Diuretic responses to oral and intravenous water loads in patients with hepatic cirrhosis.


Human serum lipoproteins.  II.  Some effects of their intravenous injection in rats.


Reactivity of hemophilic plasma to platelet thromboplastin.


Toxicity of schizophrenics' blood serum in tissue culture.


Estimation of total body chloride in man by radiobromide dilution.


Therapeutic effect of hyaluronidase in experimental tubular necrosis of kidney.


Effects of insulin hypoglycemia on renal hemodynamics.


Studies of experimental sulfhemoglobinemia.


An evaluation of the fecal recovery method for determining intestinal absorption of cobalt60-labeled vitamin B12.


Studies in leukemia.  V.  Antigenic differences between leukemic and nonleukemic red blood cells.


Studies on hepatolenticular degeneration; copper as the causative agent in the degeneration and dysfunction of electric tissue.


A simple screening test for elimination of artifactually high valued protein-bound iodine samples.


The stability of the viral potency of smallpox vaccine when prepared in the globulin and other protein fractions of calf plasma, dehydrated, and stored at tropical temperatures.


Flame photometric determination of serum calcium.


Syringe mechanism for simultaneous blood sampling at constant rates.


An enzymatic spectrophotometric method for the determination of pyruvic acid in blood.


A clinical method for the assay of serum glutamic-oxalacetic transaminase.


Technique for permanent long-term intubation of rat aorta.


Paralysis of the pharynx.

Paralysis of the pharynx.


The evaluation of serologic tests for leptospirosis.


Extra labyrinthine vertigo due to cervical muscle lesions.


Weber's test and recruitment.

Weber's test and recruitment.


Gout as a cause of respiratory obstruction.


A case of chondroma of the nasopharynx.

A case of chondroma of the nasopharynx.


A venture into the private practice of medicine.


Snapping hip; a new mechanism for its production.


Dermatological survey of hair and scalp conditions; clinical and laboratory observations.


Radioiodine as test and treatment in thyroid disease.


Trimalleolar fracture.

Trimalleolar fracture.


Welfare programs for needy patients.

Welfare programs for needy patients.


The science changes, but the art is eternal.


Exploratory laparotomy to rule out malignancy.


The duty of a doctor as a citizen.

The duty of a doctor as a citizen.


On becoming an anatomist.

On becoming an anatomist.


Teaching psychoanalytic psychiatry to medical residents.


The undergraduate teaching of ophthalmology.


The work of a department of surgery in a postgraduate medical school.


Medicine in the 19th century:  T. Clifford Allbutt; explanatory notes.


Medical education and the distribution of physicians.


SYMPOSIUM on the compensation of faculties of clinical departments.


The Duke Private Diagnostic Clinic.

The Duke Private Diagnostic Clinic.


The Chicago plan.

The Chicago plan.


Compensation of Clinical Faculty at the University of Virginia.


MEDICAL school applicants:  how many?

MEDICAL school applicants:  how many?


The Iowa College of Medicine plan for private practice.


Trends in medical practice; an analysis of the distribution and characteristics of medical college graduates, 1915-1945.


The contribution of the physical sciences to psychological medicine.


The thirtieth Maudsley lecture:  perception and imperception.


Memory function in psychiatric patients over sixty, some methodological and diagnostic implications.


A review of the psychotic elderly resident in a mental hospital.


Clinical applications of EEG in psychiatry.


A re-evaluation of the fugue.

A re-evaluation of the fugue.


Research prospects in the psychology of ageing.


Encephalitis periaxialis diffusa with survival for thirty-six years.


Spatial disorientation in senile dementia; the psychological mechanisms disturbed and some suggested methods of compensation.


Friederich C. G. Scheidemantel:  the first systematic text in psychosomatic medicine (1787).


The psychoses of adolescence.

The psychoses of adolescence.


Colour-form response as a function of mental disorder.


Some aspects of the Ganser state.

Some aspects of the Ganser state.


The cephalic post-traumatic syndrome; pathological observations.


A logical and cultural analysis of hallucinatory sense-experience.


The neuropsychiatric aspects of familial dysautonomia (the Riley-Day syndrome).


Cerebral cysticercosis with mental symptoms.


Mental illness and social conditions in Bristol.


The treatment of depression with methylamphetamine.


Mercaptomerin sensitivity and insulin reaction during hyperglycemia in the same patient; case report.


Silicosis; a new aid in the diagnosis of silicosis.


Chlorpromazine in the treatment of chronic psychotic patients.


Anatomical considerations in surgery of the gall bladder.


Classification and treatment of temporomandibular joint problems.


Vaginal delivery following cesarean section.


Vaginal discharge.

Vaginal discharge.


Single versus multiple lead electrocardiograms as a screening test.


Generalized eczematoid dermatitis with severe alopecia due to food sensitivity; case report.


The role of the family physician in psychiatric problems.


Social and economic aspects of medicine.


Social trends.

Social trends.


MICHIGAN medical service; yesterday-today-and-tomorrow.


Humoral physiology-psychology and Shakespeare's dramas.


Controlled study on clinical use of reserpine in psychotic patients with special comments on sources of error.


The physiology of tremor and nystagmus; a kybernetic analysis.


A comparative study of the effect on anxiety of chlorpromazine, reserpine, phenobarbital, and a placebo.


An analysis of the relationship between psychological patterns and outcome in pulmonary tuberculosis.


Hypnotic phenomena, including hypnotically activated seizures, studied with the electroencephalogram.


A unitary hypothesis of disorganization:  stress-organism relationships.


Spontaneous seizures and related electroencephalographic findings following shock therapy.


Variables in the clinical evaluation of a hypnotic drug with a clinical evaluation of glutethimide.


Poet and psychiatrist Merrill Moore.

Poet and psychiatrist Merrill Moore.


Sororities, a psychiatric appraisal.

Sororities, a psychiatric appraisal.


Bulbar regions related to localized cerebellar afferent impulses.


Centrifugal impulses in rabbit's retina.


Locus of propagation of spreading cortical depression.


Laminar electrical responses in lateral geniculate body of cat.


Unitary responses to afferent volleys in lenticular nucleus and claustrum.


Effects of transections of central neuraxis on galvanic skin reflex in anesthetized cats.


Brainstem reticular system and galvanic skin reflex in acute decerebrate cats.


Gamma control of dynamic properties of muscle spindles.


A psychological investigation of primigravidae.  I.  Methods.


A radiological study of the placental stage of labour.


A psychological investigation of primigravidae.  II.  Maternal social class, age, physique and intelligence.


Brenner tumours of the ovary; a report of 2 cases presenting unusual features.


Two cases of intraperitoneal haemorrhage following normal delivery.


Localized congenital defects of the scalp.


Amenorrhoea:  an analysis of cases seen at a gynaecological endocrine clinic.


Vaginal cytology in cancer of the cervix.


The sperm anti-agglutinic factor in women.


Otto pelvis; a report of two cases associated with labour.


The value of cytology in the early diagnosis of carcinoma of cervix.


Pregnancy following uretero-colic anastomosis.


A fluid retention syndrome associated with severe iso-immunization to the rhesus factor.


A case of uterus pseudodidelphys and twin pregnancy.


Fertility after tubal pregnancy.

Fertility after tubal pregnancy.


Congenital atresia vaginae; a new modification of the Brady-Graves operation.


Genetic speculation based upon animal experimentation in relation to actual human experiences, in the treatment of female infertility and sterility by x-ray therapy.


Carcinoma of the body of the uterus and its relationship to endometrial hyperplasia; a histological study.


Anaemia in pregnancy, as encountered in Malaya.


Cyst of Skene's gland.

Cyst of Skene's gland.


Early operative interference in afibrinogenaemia of pregnancy.


A case of aneurysm of a uterine artery.

A case of aneurysm of a uterine artery.


Pregnancy in a bicornuate uterus complicated by the presence of a transverse vaginal septum.


CYTOLOGY in the diagnosis of carcinoma of the cervix.


The changing face of obstetric practice and teaching.


Employees with heart disease in industry; problems and possible solutions.


Sexual inadequacies and their management.


Mushroom poisoning.

Mushroom poisoning.


The prevention and treatment of injuries to athletes.


Chromatic adaptation.

Chromatic adaptation.


Experimental test of Luneburg's theory; horopter and alley experiments.


Differential diagnosis of fibrous dysplasia and fibro-osseous neoplastic lesions of the jaws and their treatment.


Surgical treatment of precancerous lesions of the lip.


Surgical closure of the oroantral fistula.


Treatment of extravasation cysts with freeze-dried homogenous bone grafts.


Facial pain.

Facial pain.


Chlorpromazine hydrochloride as an antinauseant and tranquilizing agent; a preliminary report.


Hemangioma of the buccal pad with phelbolithiasis.


Osteomyelitis of the mandible associated with supernumerary teeth; report of case.


Dens in dente; report of case.

Dens in dente; report of case.


Moistureproof dressing for intraoral surgery.


Persistent trismus caused by a foreign body; report of two cases.


Lingual nerve neuropathy resulting from sialolithiasis; report of case.


Midline fissure of the lower lip; report of case.


Treatment of persistent infection of the face and neck; report of case.


Metastatic cancer of the mandible.

Metastatic cancer of the mandible.


The in vitro cultivation of Nippostrongylus muris to the adult stage.


The occurrence of a dog filariid other than Dirofilaria immitis in the United States.


Studies on the serology of trichinosis with hemagglutination, agar diffusion tests and percipitin ring tests.


Relationship of size of inoculum to time to death in mice infected with Toxoplasma gondii.


Studies on the helminth fauna of Alaska.  XXVII.  The occurrence of larvae of Trichinella spiralis in Alaskan mammals.


Observations on vectors of schistosomiasis mansoni kept out of water in the laboratory.


New hosts for trematodes of the genus Heterophyes in Egypt.


An atypical Ornithodoros hermsi from Utah (ixodoidea, argasidae).


The biting midges of the genus Culicoides found in the Bermuda Islands (Diptera, Heleidae).  I.  A description of C. bermudensis n. sp. with a key to the local fauna.


The biting midges of the genus Culicoides in the Bermuda Islands (Diptera, Heleidae).  II.  A study of their breeding habitats and geographical distribution.


Two new species of ticks from Soembawa Island, Indonesia (acarina:  ixodidae).


Ischyropoda furmani n. sp., a new ectoparasitic mite from Utah.


Notes on the genus Hexostoma (monogenea:  hexostomatidae) with a redescription of H. euthynni meserve, 1938.


Trichobilharzina brantae n. sp. (trematoda:  schistosomatidae) from the Canada goose (Branta canadensis L.).


Metazoan parasites of the blue jay, Cyanocitta cristata L.


Two flukes, Phagicola macrostomus n. sp. and Phagicolabyrdi n. sp., from the turkey vulture (trematoda:  heterophyidae).


Acute barbiturate poisoning; how should it be treated?


Editorial comment on the treatment of acute barbiturate poisoning.


Chronic benign neutropenia in infancy and early childhood; report of a case with a review of the literature.


The effect of specific therapy in primary tuberculosis of the child.


Absorption of oily and aqueous preparations of tetracycline in children.


The daily circulating eosinophil response as a guide to adequacy of hormone therapy in active rheumatic carditis.


Infantile cortical hyperostosis.

Infantile cortical hyperostosis.


Consequences of neonatal pathology.

Consequences of neonatal pathology.


A new quantitative approach to the study of anthelminthic drugs, with an evaluation of piperazine hexahydrate, phthalylsulfathiazole, and RO 2-5655/3 in the treatment of Enterobius infection.


The treatment of Wilms' tumor.

The treatment of Wilms' tumor.


The influence of breast feeding on weight gain in infants in the first year.


Transient synovitis of the hip.

Transient synovitis of the hip.


Meconium peritonitis:  a surgical emergency; a brief review of surgical survivals and a case report.


Hypopituitarism, hypoadrenalism, and hypogonadism in the newborn infant.


Arthrogryposis multiplex congenita; case report.


CHILDREN'S Medical Center, Boston, Massachusetts; clinical pathological conference.


Leonard Findlay; 1878-1947.

Leonard Findlay; 1878-1947.


Multiple skeletal lesions in young children due to trauma.


An appraisal of certain acute phase reactants in a single blood sample and their value in the diagnosis of acute rheumatic fever.


Evaluation of a new liquid dosage form of hydrocortisone.


The incidence of abnormal blood levels of lead in a metropolitan pediatric clinic; with observation on the value of coproporphyrinuria as a screening test.


Corticotropins in the treatment of transient synovitis of the hip in children.


A syndrome simulating encephalitis affecting children recovering from malnutrition (kwashiorkor).


The treatment of common anemias in infancy and childhood with a cobalt-iron mixture; including a case report of iron deficiency anemia due to geophagia.


The fight against infectious hospitalism in a children's nursery and hospital.


The effect of simulated exchange transfusion in puppies.


Relationship of retrolental fibroplasia to oxygen concentration.


Androgenic precocity and congenital cerebral cortical atrophy.


Sarcoma of the prostate in a fourteen-month-old child.


Phthiriasis palpebrarum (phthiriasis ciliaris).


CHILDREN'S Medical Center, Boston, Mass.; clinical pathological conference.


Arachnidism in children.

Arachnidism in children.


Thomas Morgan Rotch (1849-1914).

Thomas Morgan Rotch (1849-1914).


Complications of small-pox vaccination and their treatment with vaccinia immune gamma globulin.


Amino aciduria, congenital defects, and mental retardation; a preliminary report.


The treatment of diabetic acidosis:  comparison of treatment regimes with and without parenteral potassium.


Convulsions in tuberous sclerosis controlled by elimination of impulses originating in the basal ganglia.


Intramuscular iron for the treatment of iron deficiency anemia in infancy.


Aneurysm of thoracic aorta in an infant treated by resection and arterial homograft.


Portal hypertension in a child diagnosed by splenoportogram.


On the nature of the stenosis in congenital hypertrophic pyloric stenosis; report of a case of pyloric stenosis in which a No. 14 catheter was inadvertently passed through the pyloric sphincter.


Malignant thymoma, lymphocytic type.

Malignant thymoma, lymphocytic type.


CHILDREN'S Medical Center, Boston, Mass. Clinical Pathological Conference.


Congenital atresia of the ileum in two brothers; case report.


The bacterial flora of the intestinal tract:  changes in diarrheal disease and following antimicrobial therapy.


George Frederic Still, 1868-1941.

George Frederic Still, 1868-1941.


Central effects of antitussive drugs on cough and respiration.


A study of the neuropharmacologic properties of certain convulsants, anticonvulsants and reserpine.


The effect of pancreatectomy on the toxicity of k-strophanthin in the dog.


Effects of reserpine on conditioned avoidance behavior in normal and brain-operated monkeys.


The metabolic conversion of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin) and of 5-ethyl-5-phenyl hydantoin (nirvanol) to 5 - ethyl -5- (p-hydroxyphenyl) hydantoin.


Actions of certain antibiotics on the isolated dog heart.


Blockade by brom-lysergic-acid-diethylamide (BOL) of the potentiating action of serotonin and reserpine on hexobarbital hypnosis.


Ganglionic blocking properties of 3-methylaminoisocamphane hydrochloride (mecamylamine):  a secondary amine.


The anesthetic effects of ethyl vinyl ether, divinyl ether, and diethyl ether on mice.


Nalorphine, a potent analgesic in man.

Nalorphine, a potent analgesic in man.


The direct antithyroid action of reserpine, chlorpromazine and other drugs.


Effects of cortisone upon liver enzymes and protein synthesis.


Modification of the effects of sympathomimetic amines and of adrenergic nerve stimulation by 1-isonicotinyl-2-isopyropylhydrazine (IIH) and isonicotinic acid hydrazide (INH).


The conversion of dihydroxyphenylalanine-2-C14 (DOPA) to norepinephrine by bovine adrenal medullary homogenates.


The effect of a vasoconstrictive agent, metaraminol, on human tolerance to acceleration.


Release of blood platelet serotonin by reserpine and lack of effect on bleeding time.


The effects of quinidine, procaine amide and pyrilamine on the membrane resting and action potential of guinea pig ventricular muscle fibers.


Drug alteration of transmembrane potentials in atrial pacemaker cells.


The effects of morphine-nalorphine mixtures on psychomotor performance.