Observations on the carbon dioxide absorption properties of monoethanolamine.


Ganglionic blockade and its protective action in hemorrhage; a review.


The influence of meperidine on myocardial contractility in the intact dog.


Some sequelae of medullary nailing of long bones.


Recovery from thiopental and methitural; nitrous oxide anesthesia for a standard short procedure.


Urine secretion during diffusion respiration after apnea from neuromuscular block.


Experimental production of ether convulsions.


Healing of the bronchial stump after pneumonectomy; influence of the growth hormone.


Alphaprodine hydrochloride with levaliorphan tartrate or RO 1-7780 postoperatively.


The more recent indications for tracheotomy.


Extracorporeal circulation in man.

Extracorporeal circulation in man.


ADAPTATION of Jefferson ventilator for use with circle filter.


Undescended testis; indications and results of operation.


The vacuum phenomenon in knee- and shoulder-joints.


Effect of anesthetic agents on evoked central nervous system responses; gaseous agents.


Granuloma caused by talc in the resection stump of the stomach; a rare late complication of gastric resection treated by total gastrectomy.


The respiratory effects of N-allylnormorphine in secobarbital sodium narcosis.


Adenolymphomas of the parotid region.

Adenolymphomas of the parotid region.


Surgical treatment of irradiation burns.


Neuropathic arthropathy caused by spinal cord trauma.


Fertility after low caesarean section.

Fertility after low caesarean section.


Are there arteriovenous anastomoses in the human forearm?


Presacral dermoid cyst obstructing delivery.


Present-day treatment of tetanus.

Present-day treatment of tetanus.


Use of bronchography in pulmonary tuberculosis.


Subtotal esophagectomy and high intra-thoracic esophagogastrostomy for lye stricture of the esophagus; report of case followed up for 6 years.


Experience in the use of hyaluronidase in outpatient surgery.


Results of surgery in the treatment of pulmonary tuberculosis.


Mortality from appendicitis; a study of 75,520 Finnish cases from the years 1951-55.


The regenerative ability of the auto-plastic and deep-frozen homoplastic transplant of bone; a comparative experimental study.


Large primary omental cyst in an adult.

Large primary omental cyst in an adult.


Combination of moderate hypotension and chlorpromazinepotentiated anesthesia.


A rare mesenchymal mediastinal tumour; case report.


The roentgenological diagnosis of osteogenic sarcoma and osteomyelitis.


Arteriovenous fistulas and arterial aneurysms.


Investigations into the excretion mechanism of indigo carmine in normal human kidney.


The value of the disc operation in prolonged disabling sciatica; a clinical study with an evaluation of results and symptoms based on follow-up examination of 104 cases.


[The question of prolonged pregnancy].

[The question of prolonged pregnancy].


Clinical symptoms and radiological changes in Bechterew's disease.


Transplantation of bone; an experimental study.


[Treponema-immobilizing antibodies in syphilis.  I.  Principle and risks in their determination; their effect on the biology of treponemas; respective roles of treponema infection and secondary reactions in syphilitic disease].


A comparison of bacterial growth on fresh meat and on frozen meat after thawing.


The suitability of the range 30-32 degrees C as the single incubation temperature in the bacteriological examination of foods.


[Differential diagnosis between induced abortion & pathological (spontaneous) abortion].


Detection of a new Escherichia coli type, 55:B5:32 associated with infantile diarrhoea.


Serum proteins in dehydration in young rats.


Succinic dehydrogenase activity in male accessory sex organs of intact, testosterone-treated and castrated rat; a histochemical study.


Observations on the use of radioactive gold (Au 198) in the treatment of malignant tumours of the lungs and pleura.


Experiments of the effect of radioactive gold (Au 198) on the tracheal tissue of animals.


Effect of subperitoneally injected tween 60 and tween 80 on rats.


Short-time effect of benzopyrene on eosinophils; observations on the short-time effect of orally administered benzopyrene upon the number of eosinophilic cells in the alimentary canal, bone marrow and blood of the rat.


A method for the determination of the penicillin level in various parts of the resected lung.


Coxsackie antibodies in domestic animals and Norway rats.


Factors in serum affecting the growth of HeLa cells.


Chromatographic studies of amino acid constituents of pure canine duodenal juice.


Some new blood group specific phytagglutinins; a preliminary report.


Effect of bacitracin and neomycin on the bacterial flora of the colon.


Influence of hyperthyroidism and hypothyroidism on guinea-pig tuberculosis.


Experimental factors influencing anaphylactic shock in guinea-pigs; preliminary report.


The effect of zymosan on susceptibility to staphylococcal infections in mice.


An attempt at shortening the diagnostic guinea-pig test.


Effect of chlorpromazine-hibernation on staphylococcal infection; quantitative bacterial population studies.


Transmission of antibodies from mother to fetus; a study of the diphtheria antitoxin level in the newborn with oesophageal atresia.


Is the sex ratio between boys and girls correlated to the sex of precedent children?


Blood group A1; a possible subdivision into two types, probably hereditable.


The water content of the alcoholic precipitate of normal and rheumatic sera.


Relationship between buffer capacity and pH in the blood of surgical patients.


Effect of infusions on the buffer capacity of blood.


Methods of determining the buffer capacity of blood.


Uropepsin excretion in partially gastrectomized peptic ulcer patients with postcibal symptoms.


Sensitivity of the genus Proteus to antibiotics.


Sensitivity of the genus Proteus to sulphonamides.


Observations on experimental fibrinolysis in rabbits.


Studies on the local reactions of the skin to chemical compounds.


Observations on the Donaggio reaction.

Observations on the Donaggio reaction.


Amyloidosis as a stress disease.

Amyloidosis as a stress disease.


Effect of paraaminosalicylic acid (PAS) on thyroid activity; an experimental histo-quantitative study.


Determinations of streptomycin in various parts of the resected tuberculous lung.


The ABO blood group and carcinoma of the stomach.


Effects of anesthesia and operation on blood sugar; an experimental study on normal and alloxandiabetic rabbits.


Deoxyribonucleic acid in sputum; studies on patients with bronchiectasis, pulmonary tuberculosis and pulmonary carcinoma.


Studies in the viscosity of bronchial mucus.


A study of the occurrence of poliomyelitis and of neutralizing antibodies against the three types of poliomyelitis virus in Finland.


The adrenal cortex and administration of ACTH, cortisone and a combination of ACTH and cortisone.


Investigations on Escherichia coli O groups 1-25, 44 and 78 and serotypes 26:B6, 55:B5, 86:B7, 111:B4, 125:B15 and 126:B16; occurrence in faeces of healthy and diarrhoeal infants.


Effect of denervation and utero-renal reflexes on the function of the rabbit kidney.


Histologic and bacteriologic investigations on patients with pulmonary resection treated with antibiotics.


Effect of adrenocortical hormones on hydroxyproline concentration of heart and skeletal muscle; an experimental investigation with mice.


Neurological and physiological studies on distilled and brewed beverages.


Studies of serum lipids and lipoproteins in bleeding anaemia in rabbits.


Studies in hemagglutinins of leguminosae seeds.


Prognosis of illness and appearance of Q waves on electrocardiograms in myocardial infarction.


Determination of cardiac output from blood pressure measurements and by the dye dilution method.


Management of shock with corticotropine (ACTH) in myocardial infarction.


Multiple myeloma simulating hyperparathyroidism.


Two cases of malignant reticulosis.

Two cases of malignant reticulosis.


Assay of thyrotropic hormone in human blood in some cases of thyroid disease.


Exceptional mobility of the motional segments of the lumbar spine in antero-posterior flexion.


Studies in the composition and proteolysis of resected lung tuberculomas.


Simultaneous radiography of the bile ducts and stomach in cases of gastric resection.


Applicability of a rapid method to the determination of the erythrocyte sedimentation rate; comparison with Westergren's method.


Intravenous cholangiography in the diagnosis of intermittent juvenile icterus.


[Deafness caused by a jet helicopter].

[Deafness caused by a jet helicopter].


Clinical symptoms of respiratory disorders in newborns.  I.  Symptoms of neonatal pneumonia.


An outbreak of infantile diarrhoea associated with a new Escherichia coli serotype 55:B5:32.


Congenital tracheal stenosis combined with truncus arteriosus cordis; a case diagnosed intra vitam.


Tetracycline in the treatment of scarlet fever.


Pulmonary vascular changes in patent ductus arteriosus.


Maxillary sinusitis in scarlet fever patients treated with antibiotics.


Sacrococcygeal and urological anomalies in connection with congenital malformations of anus and rectum; a preliminary report.


Titrimetric determination of the water content of plasma and erythrocytes.


Heart volume during pregnancy with special consideration of its reduction.


Excretion of the total 17-hydroxycorticosteroids into the urine of newborn prematures and infants (boys) during the first two days and the first month; a preliminary report.


Does hypoxia cause an increased conversion of carbohydrate to fat?  Experiments performed on young rats with C14 labeled glucose.


Adrenal corticoids in the treatment of tuberculous meningitis.


Response of plasma 17-hydroxycorticosteroids to intravenous ACTH infusion in normal children.


Effect of cobalt on the reticulocyte counts of young premature infants.


Is acute heart failure the cause of the neonatal-syndrome in children born of diabetic mothers?  a preliminary report.


Pericarditis caused by Coxsackie virus B.


The importance of nutrition in infection and allergy.


Hand deformities in rheumatoid disease.

Hand deformities in rheumatoid disease.


Electron microscopic study of the effect of prolonged heat and ultra-violet light on human dermis from different age groups.


The use of an anticholinergic drug in the treatment of asthma.


Therapeutic effectiveness of elixophyllin for the oral treatment of acute and chronic bronchial asthma.


Corticosteroid metabolism and rheumatoid arthritis.


Intra-cutaneous Congo red in rheumatoid arthritis.


Myalgic syndrome with constitutional effects; polymyalgia rheumatica.


Honeycomb lung and chronic rheumatoid arthritis; a case report.


Hyaluronic acid in Heberden's nodes.

Hyaluronic acid in Heberden's nodes.


Provocative x-ray therapy as a new aid to the diagnosis of suspected sinusitis.


Tumours of the parotid gland.

Tumours of the parotid gland.


Tripelennamine hydrochloride and chlorprophenpyridamine maleate; a comparison of their efficacies in the treatment of hay fever.


Allergy and the diffuse collagen diseases.


Clinical evaluation of sandostene, a new antihistaminic drug, in allergic diseases; results of a double-blind investigation.


Paralytic scoliosis.

Paralytic scoliosis.


The clinical importance of food dislikes in allergic children.


A surgeon's outlook.

A surgeon's outlook.


Miscellaneous review of allergy:  1956.

Miscellaneous review of allergy:  1956.


Diagnosis and treatment of diseases of the large intestine.


An experiment on the infectivity to Glossina morsitans of a strain of Trypanosoma rhodesiense and of a strain of T. brucei, with some observations on the longevity of infected flies.


Congenital spinal palsy; the management of incontinence.


Age analysis in the bitingcycle of the mosquito Taeniorhynchus (Mansonioides) africanus Theobald, based on the presence of parasitic mites.


The erythrocyte sedimentation rate in sleeping sickness.


Observations on the oviposition-cycle of Aëdes (Stegomyia) aegypti (Linnaeus).


Laboratory observations on the oviposition-cycle in the mosquito Aëdes (Stegomyia) africanus Theobald.


Aëdes aegypti in Malaya.  III.  Experiments on control and eradication.


The influence of temperature and humidity upon the action of insecticides.  I.  During the post-treatment period.


The influence of temperature and humidity upon the action of insecticides.  II.  Temperature during the pre-treatment period.


Aortic onchocerciasis due to Onchocerca armillata in cattle in Ghana, with special reference to the morphology of the parasite.


The susceptibility of Aëdes aegypti larvae of different ages to DDT and dieldrin, and the relevance of the results to the formulation of standardized susceptibility tests for mosquito larvae.


The pathogenesis of some tropical splenomegalies.


Ammonium penicillin G:  comparisons with other oral penicillin preparations.


Clinical appraisal of two asymmetrical bisquaternary ammonium compounds (IN 292 and IN 391).  II.  Preliminary results in the outpatient treatment of hypertension.


Treatment of chronic amebiasis with oxytetracycline and tetracycline.


Treatment of common infections with tetracycline phosphate complex in office practice.


Erythromycin treatment of a diphtheria carrier epidemic in a mental deficiency hospital.


Observations on the individuality of yeast maltases.


Observations on the distribution of amine oxidase in invertebrates.


Investigation of the alkaloids of Punica granatum L.


The synthesis of 2-carboxypyrrole from D-glucosamine and pyruvic acid:  its bearing on the structure of neuraminic acid.


The glucamylase and debrancher of S. diastaticus.


Observations on the metabolism of alkylmercaptans in yeast.


epsilon-lysine acylase.

epsilon-lysine acylase.


Salts of quinidine with pyridinecarboxylic acids.


On the enzymic synthesis of lactose-1-PO4.


Deuterium exchange of poly-DL-alanine in aqueous solution.


Enzymic synthesis of polynucleotides.  III.  Phosphorolysis of natural and synthetic ribopolynucleotides.


L-penicillamine and rat liver transaminase activity.


Studies on yeast invertase; soluble and insoluble invertase (saccharase) of baker's yeast.


Some data on the growth physiology of Chlorella studied by the technique of synchronous culture.


The effects of nucleases on the reproduction of T3 bacteriophage in protoplasts of Escherichia coli.


Behavior of purified arginine desiminase from S. faecalis.


Activator-competitive enzyme inhibition; interrelation of dissociation, activation, inhibition and surface inactivation of beta-glucuronidase.


Formation of extracellular amino acids and peptides in penicillin fermentations.


Observations and reflections on manometric calibrations with air; methods for indolent mercurophobes.


Reactivity of analogs with pancreatic tryptophan-activating enzyme.


Sources of methyl malonate in rat urine; valine metabolism.


Coupled nucleoside phosphorylase reactions in Escherichia coli.


The separation of adenosinetriphosphatase and triphosphatase in rat liver homogenates.


The reductive pentose phosphate cycle.  I.  Phosphoribulokinase and ribulose diphosphate carboxylase.


Nonparticipation of inorganic phosphate in the enzymic formation of nucleotides by nucleoside phosphotransferases.


The photodynamic pigment of some species of Elsinoë and Sphaceloma.


The effect of viscosity on the electrophoretic mobilities of the components of synovial fluids and blood serums.


A soluble enzyme from mitochondria catalyzing an exchange between inorganic phosphate and adenosine triphosphate.


The antimitotic activity of cyanates on the bulbs of Allium cepa L.


Three types of inhibition of alkaline phosphomonoesterase.


C-2 and C-1 radioactive intermediates during the oxidation of labeled acetate by living yeast cells.


Oligosaccharide formation during synthesis of cellulose by Acetobacter acetigenum.


Decarboxylations and transaminations in extracts of higher plants.


Lactose synthesis.  III.  The distribution of C14 in lactose of milk after intra-arterial injection of acetate-1-C14.


Studies on succinic dehydrogenase.  V.  Isolation and properties of the dehydrogenase from baker's yeast.


Chemical and enzymic studies of thioesters of glutamic acid and glutathione.


The acid mucopolysaccharides of connective tissues.  II.  Further experiments on chondroitin sulfate B.


Studies on the interaction of diphosphopyridine nucleotide analogs with dehydrogenases.


Enzymic synthesis of L-ascorbic acid in different animal species.


A specific antidote against lethal alkyl phosphate intoxication.  V.  Antidotal properties.


Antimicrobial substances in cereals and fodder plants.


Studies on biological methylation.  XVII.  The natural occurrence and chemical reactions of some thetins.


Effects of anaerobiosis on bacteriophage synthesis.


The chemical composition of thermophilic bacilli.


Stepwise stereoisomerization of prolycopene, a polycis carotenoid, to all-trans-lycopene.


Exopeptidases of Clostridium histolyticum.


Yeast alcohol dehydrogenase II.

Yeast alcohol dehydrogenase II.


The significance of structure in certain enzymic processes.


Metabolism of mannoheptulose in the rat.  I.  Diabetogenic action.


Formation and interconversion of sugar nucleotides by plant extracts.


The formation of inorganic pyrophosphate in microsomes.


The effect of fluorocitrate on the synthesis of amino acids from ammonia and alpha-keto acids in rat liver homogenate.


Differentiation of hyperpiesin and miopiesin from hormones of the pituitary gland.


On the mechanism of enzyme action.  LXIII.  Specificity of acetylation of proteins with C14 anhydride.


Chlorogenic acid as a competitive inhibitor of indoleacetic acid oxidase.


Mammalian tropomyosins.

Mammalian tropomyosins.


Carotenoids in a 20,000-year-old sediment from Searles Lake, California.


Metabolism of taurine in the growing chicken.


Hydroxylamine and reactive acyls.

Hydroxylamine and reactive acyls.


Fractionation and characterization of the lipide stain, Sudan black B.


The purification of yeast enolase by zone electrophoresis and ion-exchange chromatography, and the existence of several active forms of the enzyme.


The role of the carbamate reaction in the calcium and phosphorus cycles in nature.


Preparation of pyridine nucleotide analogs by the carbonyl addition reaction.


Cysteine desulfhydrase activity in chick liver.


Enzymic properties of chemically prepared diphosphopyridine nucleotide analogs.


A study of the linkage of phosphorus to protein in phosphoglucomutase.


Fatty acid oxidation by means of ascorbic acid and oxygen.


The reliability of estimated rates of production in simple turnover experiments.


8-Hydroxyadenine as the intermediate in the oxidation of adenine to 2, 8-dihydroxyadenine by xanthine oxidase.


Phosphorylase and Q-enzyme in developing maize kernels.


Determination of tissue heparin.

Determination of tissue heparin.


Fructosides formed from sucrose by a Corynebacterium.


Modified bovine serum albumin.  III.  Hydrolysis studies with trypsin, chymotrypsin and pepsin.


Studies on lactose synthesis in mammary gland slices.


Evidence for the involvement of folic acid in histidine synthesis in microorganisms.


Further studies on cytoplasmic particulates isolated by gradient centrifugation.


Dihydropyrimidine nucleotide metabolism.


Characteristics of rat and guinea pig serum ribonuclease.


The effect of growth temperature on the heat stability of a bacterial pyrophosphatase.


Electric birefringence studies on two strains of tobacco mosaic virus.


Effects of gamma rays on solutions of human serum albumin.  I.  Sedimentation studies.


Effects of gamma rays on solutions of human serum albumin.  II.  Chromatographic studies.


The salting-out behavior of bovine plasma albumin; further evidence for configurational isomerization.


The enzymatic formation of bilirubin glucuronide.


Alanine-glutamic transaminase activity and protein metabolism.


Coupled phosphorylation in rat heart muscle sarcosomes.


Formation of cellulose microfibrils in a homogenate of Acetobacter xylinum.


Urocanic acid, the major acid-soluble, ultraviolet-absorbing compound in guinea pig epidermis.


A C-20beta-reductase in the pancreas and a C-20-dehydrogenase in the adrenal.


[Tetracycline as growth factor in dystrophic children].


[Prednisone in therapy of eczema in infants].


The nephrotic syndrome in early infancy:  a report of three cases.


Acute cerebellar ataxia.

Acute cerebellar ataxia.


Congenital diabetes mellitus and neonatal pseudodiabetes mellitus.


Water diuresis in children aged 1-3 years.


Diffuse progressive interstitial fibrosis of the lungs in childhood.


Diabetes mellitus in a 2-month-old Chinese baby.


Appendicitis and enterobiasis in children; a histological study of 691 appendices.


Epidermolysis bullosa hereditaria letalis:  report of a case surviving for two and a half years.


Vaccinia gangrenosa and agammaglobulinaemia.


A suggested medical classification of handicapped children.


The importance of auditory communication.


Failure of hyperimmune gamma globulin to prevent whooping cough.


Malignant hypertension due to phaeochromocytoma in a child.


Os intermetatarseum.

Os intermetatarseum.


A case of osteosclerosis with hypercalcaemia and renal failure.


Effects of A.C.T.H. on a case of tuberculous meningitis.


Transient rash and haematuria after exercise and emotion.


[Blood regeneration by a differential agglutination method in newborn treated by exchange-transfusion for incompatible Rh factors].


Congenital heart malformations in mongolism with special reference to ostium atrioventriculare commune.


The hair sign as a prognosticator of allergy.


Effect of laboratory studies on treatment of atherosclerosis.


Preparation of a coaxial electromyographic needle sterilizable by heat.


Physical medicine and rehabilitation in the member-employee program.


Foot control driving apparatus for patients having little or no function in the upper extremities.


Employment outlook for physical therapists:  a survey of salary and personnel policies.


The diagnosis of acute chest pain.

The diagnosis of acute chest pain.


The clinical use of quinidine.

The clinical use of quinidine.


Survey of human allergy to North American snake venoms.


The history of medicine in Arizona: CO2 poisoning.


Experimental and clinical evaluation of chlorcyclizine as an antitussive.


The aetiology of pituitary tumours: the role of hypogonadism and hypothyroidism.


The nature of the pigmentary disturbance in Addison's disease.


Hypoglycaemic sulphonamides in the management of diabetes mellitus.


Primary systemic amyloidosis.

Primary systemic amyloidosis.


Normal values for the red cells in Australia.


Toxoplasmosis; the diagnosis of clinical and latent infection in Australia.


The histology of generalized pulmonary emphysema.  I.  The genesis of the early centrolobular lesion: focal emphysema.


Endocardial fibroelastosis.

Endocardial fibroelastosis.


The lead content of bone in chronic Bright's disease.


Trends in anesthesia.

Trends in anesthesia.


Accident hazards of college life.

Accident hazards of college life.


The nurse: handmaiden or partner?

The nurse: handmaiden or partner?


[Histology of the otosclerotic ankylosis of the stapes with regard to its surgical mobilization].


The component acids of some Indian fresh-water fish fats.


The analysis of urinary 17-oxo steroids by gradient elution.


Sterol metabolism.  I.  The biosynthesis of [14C] ergosterol in Carpenteles brefeldianum Dodge.


Incorporation of glycine into glutathione and fibrinogen of rats under adrenaline treatment.


Sterol metabolism.  2.  The absorption and metabolism of [14C] ergosterol in the guinea pig.


The isolation of oestrone from the urine of cows in late pregnancy.


Oxidation of p-cresol and related compounds by a Pseudomonas.


The action of diisopropyl phosphorofluoridate and other anticholinesterases on amino acids.


Studies in the biochemistry of micro-organisms.  101.  The colouring matters of species in the Aspergillus nidulans group.  2.  Further observations on the structure of asperthecin.


The catabolism of glucose by strains of Trypanosoma rhodesiense.


On the determination of the time required for biosynthesis of a single protein molecule: experiments with rat pancreatic ribonuclease.


The use of the isolated perfused liver to detect alterations to plasma proteins.


The reduction of quinic acid to dihydroshikimic acid by certain lactic acid bacteria.


Interrelationships between lysine and alpha epsilon-diaminopimelic acid and their derivatives and analogues in mutants of Escherichia coli.


X-ray data for melezitose.

X-ray data for melezitose.


Glutamic dehydrogenase in the developing chick embryo.


The origin of melezitose: a biochemical relationship between the lime tree (Tilia spp.) and an aphis (Eucallipterus tiliae L.).


Studies on the carbohydrate metabolism of skin.


The preparation and properties of ribonucleic acids from rat liver.


Isolation and properties of malic dehydrogenase from ox-heart mitochondria.


A study of the cytochromes of Octopus vulgaris Lam.


Absorption and metabolism of [14C] allethrin by the adult housefly, Musca domestica L.


Beta-Glycosidase of potato.

Beta-Glycosidase of potato.


The metabolism of 8-azapurines.

The metabolism of 8-azapurines.


Adenine succinic acid and adenylsuccinic acid from mammalian liver: isolation and identification.


The effects of proteolytic enzymes on the hyaluronic acid complex of ox synovial fluid.


The acid phosphatases of rat liver.

The acid phosphatases of rat liver.


The hydrolysis of glucose 1-phosphate by rat liver extracts.


Studies on sulphatases.  16.  A soluble preparation of arysulphatase C of rat-liver microsomes.


Studies on sulphatases.  17.  The action of surface-active agents on the arylsulphatase C of rat liver.


THE STRUCTURE of nucleic acids and their role in protein synthesis.


Recent views on the chemical structure of the polynucleotides.


Molecular structure of deoxyribose nucleic acid and nucleoprotein and possible implications in protein synthesis.


Cytological aspects of the nucleic acids.


Nucleic acids and the incorporation of amino acids.


Nucleic acids and protein synthesis in animal tissues.


Interrelationships of nucleic acid and protein in the multiplication of bacteriophage.


Spectrophotometrical investigations on enzyme systems in living objects.  II.  Cytochromes a and a3.


The isolation of sperm antagglutin from the follicle fluid, and some of its properties.


The isolation of pyridoxal-5-phosphate from crystalline muscle phosphorylase.


A new homogenizer for the isolation of nuclei in concentrated glycerine.


Studies on the mechanism of fatty acid synthesis.  II.  Cofactor requirements of the soluble pigeon liver system.


Fluorescence spectrophotometry of pyridine nucleotide in photosynthesizing cells.


Studies on the mechanism of fatty acid synthesis.  III.  Products of enzymic synthesis of fatty acids.


Protein synthesis in rat pancreas.  I.  Intracellular distribution of amylase.


The cleavage and synthesis of cystathionine in wild type and mutant strains of Neurospora crassa.


Synthesis of nucleic acids by chick blastoderms grown on synthetic medium.


Synthesis of nucleic acids in ultraviolet-treated Escherichia coli.


Fractionation of immune rabbit serum gamma-globulin.


Borate and phosphoglucose isomerase in the assay of phosphomannose isomerase.


Freezing in yeast cells.

Freezing in yeast cells.


Infectivity of viral nucleic acid.

Infectivity of viral nucleic acid.


Studies on photosynthetic phosphorylation.  I.  Photosynthetic phosphorylation under anaerobic conditions.


The linkage of sodium, potassium, and ammonium active transport across the human erythrocyte membrane.


The kinetics of enzyme action.  II.  The terminal phase of the reaction.


The binding of aldolase to isolated nuclei.


The reaction of beta-mercaptopyruvate with lactic dehydrogenase of heart muscle.


Metallo-enzymes in the reduction of nitrite to ammonia in Neurospora.


Comparative biochemistry of the biological reduction of fumaric acid.


Formic acid oxidation in Aspergillus niger.


Intermediates in the enzymic oxidation of catechol.


Inactivation of desoxyribonuclease I by x-rays.  IV.  Changes in amino acid composition and ultraviolet light absorption induced by ionizing radiation.


The action of chymotrypsin on N-alkyl derivatives of phenylalanine ethyl ester.


A study on the metabolic state of proteins in the cells of two ascites tumors.


A note on the deacylation of the carcinogen 2-acetamidofluorene and related compounds by rat liver and intestine.


The guanidination of some biologically active proteins.


The in vitro inhibition of acetyl phosphatase by thyroxine.


Quantitative determination of 0.5-5 ag of amino acid nitrogen on paper chromatograms and in solution.


Incorporation of 32P in vivo into deoxyribonucleic acid (DNA) of rabbit appendix.


The conversion of 1-13C-D-glucuronolactone to 5-13C-L-xylulose in a pentosuric human.


The origin of thymine and cytosine in Tetrahymena.


Cross linking of collagen by S- and N-mustards.


Quantitative aspects of CO2 fixation during protein synthesis from ammonium acetate.


Optical rotation and anion binding in acid solutions of serum albumin.


The site of galactoside-permease activity in Escherichia coli.


The potential for the formation of a biosynthetic enzyme in Escherichia coli.


The C-terminal amino-acid sequence of lysozyme.


Mechanism of the action of glyoxalase I.


The formation of adenosine-3'-phosphate-5'-phosphosulfate in extracts of chick embryo cartilage and its conversion into chondroitin sulfate.


Instability of ketopentose-5-phosphates in buffer solutions of varying pH.


On the mechanism of incorporation of adenylic acid form adenosine triphosphate into ribonucleic acid by soluble mammalian enzyme systems.


Acid and base catalysis in a non-enzymic transfer reaction; a possible enzyme model.


Isolation of a quinone from beef heart mitochondria.


Fractionation of microsomal proteins by a non-inoic detergent.


On the mechanism of activation of acetyl glutamic acid.


A b-type cytochrome form Streptomyces fradiae.


Microsomal cytochrome reductase.

Microsomal cytochrome reductase.


The influence of actin upon myosin ATPase.


Plasma adenosine deaminase activity in tumour cases.


Effect of ATP and acid swelling of collagen.


An asymmetric catalyst; a hydrogenase model.


Incorporation mechanisms in nucleic acid biosynthesis.


Studies on the incorporation of phosphate into casein in the lactating mammary gland.


Some recent progress in the biosynthesis of tri- and oligosaccharides.


A new type of myoglobin isolated and crystallized from the muscles of Aplysiae.


[Quantitative determination of adenosinetriphosphatase and adenosinediphosphatase].


Variation in the duration of survival of patients with acute leukemia.


Studies in leukemia.  VII.  The induction of leukemia in Swiss mice by means of cell-free filtrates of leukemic mouse brain.


An abnormal hemolytic system associated with leukemia and other disseminated malignant diseases.


Experimental hemolytic anemia in rabbits; protective role of sensitization to the species-specific protein of the heteroimmune hemolytic serum.


Platelet functional defects in thrombocytopenic purpura.


In vitro effects of x-radiation on white blood cells and blood platelets.


Experimental treatment of total-body irradiation injury: a brief review.


Therapeutic results in treatment of Hodgkin's disease with CB 1348 and R-48.


Varicose veins and venous stasis.

Varicose veins and venous stasis.


Management of facial fractures.

Management of facial fractures.


Mobilization of the stapes; a technique for the surgical treatment of otosclerosis.


Anticoagulant therapy in myocardial infarction.


Carcinoid tumors of the rectum with metastases; report of two cases.


Subdural effusions complicating purulent meningitis; report of ten cases.


THE MASS BCG vaccination campaign in Jamaica.


[Present semiological evaluation of pregnandiol in urine].


Unilateral exophthalmos; a consideration of symptom pathogenesis.


Changes in the nervous system in acute porphyria.


The incidence of Ammon's horn sclerosis.


Necrotizing encephalitis.

Necrotizing encephalitis.


An investigation of sound localization in patients with neurological abnormalities.


The conditioned inhibition of uncinate fits.


Observations on the topography of the lateral column of the human cervical spinal cord.


Corticofugal fibres to the nuclei of the dorsal columns; an experimental study in the cat.


Auscultatory and phonocardiographic signs of pulmonary stenosis.


The small pulmonary blood vessels in atrial septal defect.


Atrial septal defect in children.

Atrial septal defect in children.


Prognosis of isolated ventricular septal defects.


Aortic origin of the right pulmonary artery.


Pulmonary vascular patterns in pulmonary hypertension.


Additional electrocardiographic signs of cardiac pain.


The effect of serpasil in pulmonary hypertension.


Networks in the right side of the heart.


Malignant auricular arrhythmia.

Malignant auricular arrhythmia.


Functional tricuspid incompetence in relation to the venous pressure.


The mechanical properties of the lungs in patient with periodic breathing.


Endocardial cushion defects; common atrio-ventricular canal and ostium primum.


The haemodynamics of mitral stenosis before and after commissurotomy.


Sino-auricular block associated with intrathoracic new growths.


Absence of pulse in both upper extermities due to an aortic arch anomaly.


Calcified cardiac aneurysm.

Calcified cardiac aneurysm.


Experimental studies with prestonal, a new short-acting muscle relaxant.


Release of adrenergic catechols after the administration of hex methonium bromide.


Hypothermia for cardiovascular surgery:  acidosis in the rewarming period.


General anaesthesia in ophthalmic surgery.


Some observations on severe tetanus treated by paralysis and I. P. P. R.


On chloroform and other anaesthetics; their action and administration.


A vaporizer for fluothane.

A vaporizer for fluothane.


Pernicious anaemia.

Pernicious anaemia.


Ocular changes in diabetes mellitus.

Ocular changes in diabetes mellitus.


Electrocardiogram of early and mild coronary occlusion.


The role of radiology in gynaecology.

The role of radiology in gynaecology.


Steatorrhoea.

Steatorrhoea.


Demonstrations in pathology:  bones.

Demonstrations in pathology:  bones.


Health hazards to agricultural workers.

Health hazards to agricultural workers.


Assessing the health of the industrial worker.


The control of industrial bladder tumours; a code of working practice recommended by the British Dyestuffs Industry for the manufacture and use of products causing tumours of the bladder.


A routine method for the preparation of the cells of urine.


A study of the thermal environment in non-ferrous foundries.


The testing of life-jackets.

The testing of life-jackets.


Gamma radiography in industry.

Gamma radiography in industry.


The corrosion of metal by palmar sweat.

The corrosion of metal by palmar sweat.


A house-surgeon's observations on bronchitis in North Staffordshire pottery workers in 1864.


Excretion of urinary coproporphyrin in lead poisoning.  I & II.


Tracheotomy in major chest injuries.

Tracheotomy in major chest injuries.


Further studies on the distensibility of the eye.


Observations on photo-chemical reactions in living eyes.


Studies on developing retinal vessels.  V.  Mechanism of vaso-obliteration; a preliminary report.


A modification of the Smith Indian technique of intracapsular cataract operation.


Benign calcifying epithelioma.

Benign calcifying epithelioma.


Electrical cataract produced by a 240-volt current.


Congenital pterygium.

Congenital pterygium.


New appliances.

New appliances.


Two new synechia knives.

Two new synechia knives.


Effect of chain length of aliphatic amines on histamine potentiation and release. Diamines in the series NH(2).(CH(2))(n).NH(2) specifically potentiate histamine contractions of the guinea-pig ileum and inhibit the enzymatic destruction of histamine. These activities are greatest with short-chain compounds (n approximately 5). Diamines also release histamine from isolated tissues and depress the contractility of plain muscle and the motility of paramecia. These activities increase with chain-length and are probably limited only by solubility. The parallelism between histamine-releasing activity and toxicity also extends to the monoamines in the series CH(3).(CH(2))(n-1).NH(2). Histamine-releasing activity of both series increases with increase of pH and can mainly be attributed to the non-ionized base.From the results on the effect of chain-length and ionization on activity, it is suggested that aliphatic amines release histamine by penetration of the cell membrane in the non-ionized form, followed by exchange in the ionic form with intracellular histamine.


The activity of different steroids in producing thymic involution. The assay method for corticotrophin, in which the involution of the thymus of the nestling rat is measured, can be applied successfully as a quick and simple screening test for biologically active corticosteroids. The sensitivity of the test is such that injection of a standard dose of cortisone acetate produces different results when made up in different media, or injected by different routes. A standard procedure for dispensing and injecting the steroids has therefore been adopted. Of the steroids investigated, it is noticeable that those possessing marked thymolytic activity are also steroids with therapeutic properties.


A comparative study of kinin, kallidin, and bradykinin. Partially purified kinin, a polypeptide in wasp venom, has been found to be a potent smooth-muscle stimulating and hypotensive agent. Such a preparation was 10 to 100 times more effective than histamine in enhancing capillary permeability on intradermal injection, and 10 times more effective than acetylcholine in evoking pain on a cutaneous blister base. Some differences between the actions of salivary kallikrein and trypsin in releasing kallidin or bradykinin have been observed, and some modifications of previous methods of preparing crude kallidin and bradykinin are suggested. Kallidin and bradykinin are effective enhancers of capillary permeability in the guinea-pig and rabbit. Chemical and pharmacological tests failed to differentiate between kallidin and bradykinin which must be, therefore, closely similar compounds. The possible role of kallidin and bradykinin in physiological or pathological conditions is discussed.


Hypothalamo-neurohypophysial involvement in the corticotrophic action of acetylcholine. Acetylcholine produced a fall of blood eosinophils and adrenal ascorbic acid in normal rats; these effects did not occur in hypophysectomized animals or in hypophysectomized animals bearing a pituitary homotransplant in the anterior chamber of the eye. Acetylcholine had a striking and long-lasting antidiuretic effect in normal rats, which was abolished by hypophysectomy. In normal dogs, intravenous injections of acetylcholine raised the concentration of posterior pituitary antidiuretic hormone in the cerebrospinal fluid. These results are discussed in connexion with the hypothesis that posterior pituitary antidiuretic hormone may be the neurohumoral substance involved in the hypothalamic control of the anterior pituitary.


The relationship between inhibition of phosphofructokinase activity and the mode of action of trivalent organic antimonials on Schistosoma mansoni. The addition of purified mammalian phosphofructokinase to homogenates of schistosoma mansoni increased the rate of lactic acid production from glucose and reversed the inhibition of glycolysis produced by low concentrations of trivalent organic antimonials. Neither mammalian phosphofructokinase nor trivalent antimonials affected the rate of lactic acid production from fructose-1:6-diphosphate (HDP) by schistosome homogenates. Accordingly, in the schistosome, the rate of glycolysis of glucose is determined by the activity of phosphofructokinase.The aldolase of S. mansoni has a high requirement for HDP; relatively slight reductions in the concentration of this substrate below the optimum resulted in a sharp decline of aldolase activity. Therefore, decreased formation of HDP, due to inhibition of schistosome phosphofructokinase activity by antimonials, reduced the activity of aldolase and resulted in an inhibition of glycolysis of schistosome homogenates.Kinetic data revealed differences in the nature of the phosphofructokinase of S. mansoni and that of the enzyme catalysing the same reaction in the host. Exposure of schistosomes to low concentrations of potassium antimonyl tartrate or administration of subcurative doses of stibophen to the host resulted in an accumulation of the substrate (fructose-6-phosphate), and a reduction of the product (HDP) of the phosphofructokinase reaction, indicating that the activity of this enzyme was inhibited by antimonials in the intact parasite. It is concluded that inhibition of phosphofructokinase activity can account for the mechanism of the chemotherapeutic action of trivalent organic antimonials in schistosomiasis.


Antimalarial activity of hydroxy-substituted naphthalene compounds. A new series of mono- and di-hydroxy substituted naphthalene compounds was synthesized and found to possess antimalarial activity against P. gallinaceum infection of young chicks. A representative compound with a high degree of activity was chosen for extensive testing against other malarial species and for pharmacological investigation. The formula of this compound, number 377C54, was 1:6-dihydroxy-2:5-bis(cyclohexylaminomethyl)naphthalene dihydrochloride. Effective doses against P. gallinaceum in chicks, P. berghei in mice and P. cathemerium in canaries were 2.3, 4.0, and about 6 mg./kg. respectively. Compound 377C54 acted rapidly against the parasitaemia of P. gallinaceum in chicks and P. knowlesi in a rhesus monkey. Parasiticidal activity remained in the blood of chicks for a long time after a single oral dose. The drug can be estimated by the production of colour on coupling with diazotized p-nitroaniline. Drug concentrations in blood from chicks and humans rose rapidly after oral administration. In tissues from chicks, particularly liver and lung, the drug persisted for a long period. An unsuccessful attempt was made to induce resistance to 377C54 in a strain of P. gallinaceum. Extensive pharmacological investigation showed that 377C54 possessed no special pharmacological properties.


The pharmacological actions of murexine (urocanylcholine). Murexine or urocanylcholine is a naturally occurring choline ester of urocanic acid which was found in very large amounts in the hypobranchial body of Murex trunculus and other prosobranchiate molluscs. In vertebrates and invertebrates, it was found to possess marked neuromuscular blocking and nicotinic actions, but was almost devoid of muscarinic effects. The blocking action of murexine was considered, on the basis of experimental and clinical evidence, to be of the "depolarizing" type. It was weaker than, but qualitatively very similar to, that produced by suxamethonium. The nicotinic action of murexine was stronger than that of suxamethonium in both experimental animals and human beings.


Sulphadimidine, pyrimethamine and dapsone in the treatment of toxoplasmosis in mice. Sulphadimidine, dapsone, and pyrimethamine have been tested alone and in various combinations for their therapeutic effect against toxoplasma infection in mice. In the treatment of active infection, sulphadimidine by itself was effective, but relapses were common. Pyrimethamine gave complete cures and prevented the carrier state when used in doses near to the toxic level. Dapsone alone was not as good as either of the other two drugs tested. The best combination was found to be sulphadimidine and pyrimethamine, which were synergic. In doses well below the toxic level, this combination not only controlled the acute infection but also prevented relapses and the development of the carrier state. Dapsone and pyrimethamine were also synergic, but were not as effective as the previous combination. No synergy was found between dapsone and sulphadimidine. The mechanism of relapse and the development of the carrier state and the modes of action of the drugs alone and in combination are discussed.


The treatment of experimental toxoplasmosis in rabbits. Sulphadimidine alone is of little value in treating experimental toxoplasmosis in rabbits, because most rabbits acetylate the drug very rapidly. Within a short time of dosing such animals, there is little or none of the uncombined drug in the blood. In rabbits which do not acetylate sulphadimidine rapidly, relatively high concentrations of the free sulphonamide can be attained in the blood: in such animals, toxoplasmosis responds to treatment with sulphadimidine. Sulphathiazole is not acetylated so rapidly and is effective even in rabbits which acetylate sulphadimidine quickly. Pyrimethamine, even in doses as high as 50 mg. three times daily, is ineffective; dapsone is effective.


Oxytocic activity of basic (aminomethyl) derivatives of phenols and related compounds. A series of piperidinomethyl and related derivatives of naphthols, substituted phenols and indoles has been tested for oxytocic activity, using in vitro and in vivo methods of assay. Some of the compounds possessed very high activity, exceeding that of ergometrine. Activity was not associated with any structural resemblance to the ergot alkaloids.Highest activity occurred with 2-piperidinomethyl derivatives of phenols, among which maximum potency was conferred by substitution, at both the 4- and 5- positions, by methyl or ethyl or by linkage of these positions to form an indane derivative. In all series, piperidinomethyl derivatives were more active than those formed with other bases and methylation in the position alpha- to the nitrogen atom augmented the activity of both piperidine and morpholine derivatives. Among 2'-methyl piperidinomethyl phenols, the (-) form was more active than the (+). Acylation or alkylation of the phenolic hydroxyl group did not affect activity.The oxytocic activity was specific, the compounds being less effective upon other forms of smooth muscle. Effects upon blood pressure and respiration of a central nature were observed.


Some pharmacological actions of four synthetic analogues of oxytocin. Four structural analogues of oxytocin were investigated with regard to their oxytocic, milk-ejecting, pressor and diuretic/antidiuretic effects. In three of them the isoleucyl group of oxytocin was replaced by a phenylalanyl, leucyl, or valyl residue; in the fourth the asparaginyl group was replaced by a glutaminyl residue. Synthetic oxytocin and the international standard pituitary (posterior lobe) powder were used for comparison. Although the analogues showed marked differences in their oxytocic effects, there was a fairly good agreement between the results obtained on the isolated rat uterus and the blood pressure of the chicken for each polypeptide. The milk-ejection pressure test gave much higher values throughout. The pressor and antidiuretic activities of the four analogues showed no obvious correlation with the values obtained in the other tests. The valyl and the leucyl analogues also had a diuretic effect. The phenylalanyl analogue was remarkable for the close correspondence between its oxytocic and antidiuretic effects: practically identical values were obtained for the potency, whether measured on the rat uterus in vitro, the blood pressure in the chicken, the cat uterus in situ or water diuresis in the rat. The leucyl analogue showed an oxytocic activity on the cat uterus in situ or the rabbit mammary gland roughly 7 to 9 times as high as that measured by means of the conventional bioassay methods, such as the blood pressure of the chicken or the rat uterus in vitro. The glutaminyl analogue, the weakest of the whole series, had only a modest effect on the mammary gland. The valyl analogue was the most interesting of the new polypeptides. Its oxytocic action on the cat uterus in situ and its milk-ejecting effect were greater than that of synthetic oxytocin, whereas its antidiuretic and pressor effects were less. In cats and rats, the uterine effect was stronger in situ than in vitro. There were also distinct species differences between cats, rabbits, and rats in their sensitivity to valyl-oxytocin.


Ventricular fibrillation in the isolated rabbit heart. Ventricular fibrillation has been produced in the isolated and perfused rabbit heart by stimulating electrically at a rate from 500 to 700/min. When the perfusion fluid contained normal amounts of sodium, potassium and calcium, the fibrillation persisted after the stimulation was stopped in about 40% of hearts. When the sodium was reduced to half, tonicity being maintained by sucrose or by choline chloride, persistent fibrillation was observed in 100% of hearts. The addition of eserine or of atropine or of carbachol did not alter the percentage of hearts in which fibrillation persisted. The antimalarial compounds chloroquine, mepacrine, and pyrimethamine arrested persistent fibrillation, restoring a normal rhythm.


Lead ions and synaptic transmission in the superior cervical ganglion of the cat. The perfused superior cervical ganglion of the cat has been used to study the effect of lead ions on synaptic transmission and on the relase of acetylcholine from preganglionic nerve endings. Lead ions, in concentrations of 5 to 40 muM./l., caused block of ganglionic transmission, and reduced the output of acetylcholine. Calcium ions (10 mM./l.) relieved the block produced by lead ions and restored the acetylcholine output. The presence of lead ions does not seem to change the sensitivity of ganglion cells to injected acetylcholine.


Oxytocic polypeptides in human urine.

Oxytocic polypeptides in human urine. The work of Gomes on the polypeptide in human urine which causes contraction of the rat uterus has been extended. Concentrates were prepared by means of paper pulp columns similar to those used by Rocha e Silva and his colleagues for the purification of bradykinin, and evidence was obtained for the presence of two different active substances not only in human urine but also in a preparation of bradykinin. The effect of human urine on the rat uterus is probably due to bradykinin itself or a mixture of similar substances.


Anticonvulsant compounds and 5-hydroxytryptamine in rat brain. In rats, a series of anticonvulsant compounds have been shown to cause a significant elevation of brain 5-hydroxytryptamine (5-HT) levels in comparison with control values. This increase in 5-HT only occurred in brain tissue and was not observed in spleen, upper small intestine or blood. Elevation of brain levels of 5-HT by iproniazid (Marsilid) or 5-hydroxytryptophan failed to give protection against the convulsant or lethal action of lept zol (75 mg./kg.).


The action of ergotamine on the intracranial venous pressure and on the cerebral venous outflow of the dog. The effect of ergotamine and dihydroergotamine on the cerebral circulation was studied in the dog, anaesthetized with chloralose, by recording the intracranial venous pressure and the venous outflow from the superior cerebral vein. Under optimal experimental conditions, ergotamine (5 to 10 mug./kg.) and dihydroergotamine (100 mug./kg.) gave a marked and long-lasting cerebral vasoconstriction accompanied by a slight hypertension. The cerebral vasoconstriction provoked by ergotamine may be very small and was sometimes absent when the cerebral blood-flow was low. This vasoconstrictor effect is more pronounced the higher the initial intracranial venous pressure and hence the cerebral blood-flow. After the induction of a cerebral vasodilatation by 48/80 or strychnine, the vasoconstrictor action of ergotamine was more pronounced. The effect was not observed when CO(2) was employed to modify the intracranial venous pressure. Simultaneous registration of the cerebral, nasal cavity, and kidney vascular responses demonstrated the relative specificity of the action of ergotamine on the cerebral vessels. The small doses of ergotamine used may weaken or abolish the vasoconstrictor action of adrenaline on cerebral vessels. The modification of the responses of the cerebral circulation which such factors as anaesthesia, respiratory acidosis, and operative trauma can produce have been confirmed and emphasized. The results support the view that the vasoconstrictor action of ergotamine on the cerebral vessels might account for the therapeutic value of this drug in migraine.


The effect of cortisone on the multiplication of M. tuberculosis in normal and immune mice. The multiplication of M. tuberculosis, var. bovis inoculated into the cornea of mice was studied by staining the whole cornea at various stages after inoculation. Four groups of animals were studied: untreated animals, animals treated with cortisone, animals previously immunized with the same bovine strain, and immunized animals treated with cortisone.In the untreated immunized group little or no multiplication occurred. In the other three groups multiplication did occur and was about the same for the first week after inoculation. After this stage, cortisone-treated animals, whether previously immunized or not, showed increased multiplication and massive cord formation, as compared with untreated animals in which little further multiplication was seen. The cortisone treatment had thus completely suppressed immunity. The significance of these results is discussed.


The relation between sedation and body temperature in the mouse. Chlorpromazine and reserpine reduce locomotor activity and prolong pentobarbitone hypnosis in mice. Both these effects are shown to be proportional to the fall in body temperature produced by these drugs. Other agents are shown to reduce body temperature and potentiate pentobarbitone. At ambient temperatures of 32 degrees C. neither chlorpromazine nor reserpine is hypothermic or sedative. It is concluded that sedative effects in the mouse at ordinary room temperatures are related to the hypothermic properties of these drugs. At 36 degrees C., while reserpine fails to potentiate pentobarbitone, chlorpromazine still does so.


Prolongation of chloral hydrate sleeping time by 5-hydroxytryptamine and by certain other drugs. Various drugs have been tested for a capacity to prolong the hypnotic effect of chloral hydrate in mice. Amongst the compounds which, when injected subcutaneously in substantial amount shortly before the chloral hydrate (250 mg./kg. intraperitoneally), increased sleeping time significantly were adrenaline, noradrenaline, phenylephrine, methoxamine, 5-hydroxytryptamine (serotonin), histamine, ergotamine, yohimbine, and atropine. The ability of these drugs to prolong chloral hydrate sleeping time could not be related to any common circulatory property, but most of the active drugs are known to lower body temperature under comparable conditions. It was found that mice which have been pre-treated with 5-hydroxytryptamine or adrenaline suffer a much greater fall of body temperature when chloral hydrate is given subsequently than do mice which have been given chloral hydrate alone. It is suggested that some, at least, of the drugs which prolong the effects of hypnotics do so by virtue of a hypothermic action.


The effect of phenylbutazone upon dihydrotachysterol overdosage in the rat. Experiments on albino rats showed that short-term overdosage with dihydrotachysterol, in amounts causing only traces of soft-tissue calcification, induced a very pronounced calcium deposition in the heart, aorta, and kidney when the animals were simultaneously treated with phenylbutazone. Special attention is called to the fact that, under these experimental conditions, it is possible to obtain consistently a massive calcium deposition in the stroma of the renal papilla similar to that seen in "Randall's plaques" during the development of urolithiasis in man.


The interaction between edrophonium (tensilon) and acetylcholine at the motor end-plate. The effect of edrophonium (3-hydroxy-phenyl-dimethylethylammonium chloride) on the motor end-plate and its interaction with acetylcholine and carbachol has been investigated. Use was made of intracellular recording of membrane potential and of ionophoretic micro-application of drugs from single and twin-pipettes.Small doses of edrophonium potentiate the depolarizing effect of acetylcholine, but not that of carbachol. This action can be observed with doses of edrophonium which have no depolarizing effect by themselves. Large doses of edrophonium have some depolarizing action and, at the same time, inhibit depolarizations produced by carbachol. After treatment with neostigmine, edrophonium fails to potentiate the acetylcholine response. The observations are in agreement with the view that the principal action of edrophonium on the neuromuscular junction is that of a potent and rapidly acting anticholinesterase.


The vocational aspects of ageing.

The vocational aspects of ageing.


Ultrasonic research:  progress during the past three years.


Nosocomial physiotherapeutic disorders.

Nosocomial physiotherapeutic disorders.


CONFERENCE on electrical safety.

CONFERENCE on electrical safety.


The functional grading of abilities and disabilities.


Localized application of ultrasonic energy.


Ultrasonics in medicine.

Ultrasonics in medicine.


Report of a case:  haematoma of the larynx with complete aphonia.


THE USEFULNESS of massage.

THE USEFULNESS of massage.


Stature and weight of men from England and Wales of 1941.


Random selection in the therapeutic trial.


A note on the practical interpretation of 2 x 2 tables.


A critical examination of the reputed primary influence of ABO phenotype on fertility and sex ratio.


Recent trends of mortality from violence.


An examination of fertility of women following pregnancy according to height and weight.


Radiation induced cancer in man.

Radiation induced cancer in man.


Oxygenation in radiotherapy.  I.  Radiobiological considerations.


Oxygenation in radiotherapy.  II.  Clinical application.


Percutaneous transfemoral selective renal arteriography (including cineradiology).


Dose reduction in diagnostic radiology.

Dose reduction in diagnostic radiology.


A radiological classification of diseases.


The effect of x-rays upon the uptake of phosphorus 32 by the knee joint of six-week-old mice; modification of the effect by pre-irradiation intraperitoneal injection of cysteamine.


Low activity chromatography in radioactive iodine studies.


The lungs in heart disease.

The lungs in heart disease.


Physiological principles in the management of pulmonary emphysema.


Some aspects of the pulmonary circulation.


Chronic bronchitis in the aged.

Chronic bronchitis in the aged.


Lung scar cancers.

Lung scar cancers.


Cough fracture of the ribs.

Cough fracture of the ribs.


The Pancoast syndrome.

The Pancoast syndrome.


Stress fracture of the first rib occurring in two sisters.


An outbreak of tuberculosis in a school.


The combined use of isoniazid and nupasal-213 in pulmonary tuberculosis; a study of the toxic effects and the development of cross-resistance between isoniazid and nupasal-213 in the treatment of pulmonary tuberculosis.


Tuberculosis in the pottery industry; based on mass radiography investigations.


The functional hypopituitarism of advanced chronic pulmonary tuberculosis.


Tuberculosis and post-graduate study in Vienna during the winter 1890-91.


Epidemiology of gonorrhoea in Finland from 1953 to 1955.


Problems of venereal disease control in Poland.


Epidemiology of infections with Trichomonas vaginalis in the light of improved diagnostic methods.


Syphilophobia; a psychiatric study.

Syphilophobia; a psychiatric study.


Treatment of non-gonococcal urethritis.

Treatment of non-gonococcal urethritis.


Venereal disease in women prisoners.

Venereal disease in women prisoners.


Infection and re-infection in early syphilis.


Treatment of vaginal trichomoniasis with 2-acetylamino-5-nitrothiazole (aminitrozole) given orally.


Interstitial keratitis after adequate penicillin therapy; a case report.


Efficacy of vitamin B12 in the alleviation of the lightning pains of tabes dorsails.


Julius Wagner von Jauregg, M.D., 1857-1940; an appreciation.


Evaluation of Price's precipitation reaction in the sero-diagnosis of syphilis.


The autonomic nervous system in its relation to some forms of heart and lung disease.  I.  Heart disease.


Treatment of complete prolapse of the rectum.


Subcutaneous heparin with and without hyaluronidase.


Pulmonary tuberculosis in a rural area in South Scotland the Annandale survey.


Two cases of listerial meningitis in infants.


Penicillin V; a clinical assessment after one year.


A trial of penicillin V; response of penicillin-resistant staphylococcal infections to penicillin.


Influence of cortisone on teratogenic effects of hypervitaminosis-A.


Effect of cortisone on the incidence of cleft-palate induced by experimental hypervitaminosis-A.


A COMPARISON of cortisone and prednisone in treatment of rheumatoid arthritis; a report by the Joint Committee of the Medical Research Council and Nuffield Foundation on Clinical Trials of Cortisone, ACTH and other therapeutic measures in chronic rheumatic diseases.


Desensitization of a nurse to streptomycin under corticosteroid cover.


PENICILLIN V.

PENICILLIN V.


LISTERIAL meningitis.

LISTERIAL meningitis.


Compulsory powers over mental patients.

Compulsory powers over mental patients.


Plastic surgery of the middle ear.

Plastic surgery of the middle ear.


J.P.  HEDLEY.

J.P.  HEDLEY.


ALAN GREGG, M.D.

ALAN GREGG, M.D.


A.J. MORLAND.

A.J. MORLAND.


The autonomic nervous system in its relation to some forms of heart and lung disease.  II.  Lung disease.


PROLONGED antibiotic treatment of severe bronchiectasis; a report by a subcommittee of the Antibiotics Clinical Trials (non-tuberculous) Committee of the Medical Research Council.


Adult chronic bronchitis; the infective factor and its treatment.


Sickle-cell disease:  new method of treatment; preliminary report.


Thrombosis of internal carotid artery treated by arterial surgery.


Folinic acid in megaloblastic anaemia of pregnancy.


Rectal hydrocortisone.

Rectal hydrocortisone.


Fingerprint sweat test in fibrocystic disease of pancreas; preliminary communication.


A long-acting inhibitor of gastric secretion.


Agranulocytosis with recovery during promazine therapy.


A case of carcinoid tumour.

A case of carcinoid tumour.


MATERNAL mortality.

MATERNAL mortality.


HEPATO-LENTICULAR degeneration.

HEPATO-LENTICULAR degeneration.


CIRCUMSCRIBED myxoedema.

CIRCUMSCRIBED myxoedema.


New surgery accommodation for general practice.


Determination of success after mitral valvotomy:  role of circulatory obstruction of the myocardium and of other factors.


Teeth of 5-year-old London schoolchildren (1955) with a comparison of results obtained from 1929 to 1955.


Clinical experience with tolbutamide.

Clinical experience with tolbutamide.


Tolbutamide in treatment of diabetes mellitus.


Tolbutamide in diabetes; some clinical and biochemical studies.


Halothane:  its use in closed circuit.

Halothane:  its use in closed circuit.


Sarcosporidiosis in man with periarteritis nodosa.


Effect of a gluten-free diet in idiopathic steatorrhoea.


Cavernous transformation of the portal vein following umbilical sepsis.


Case of stove-in chest injury.

Case of stove-in chest injury.


TREMOR.

TREMOR.


THE LIVER.

THE LIVER.


LUNG CHANGES during methonium therapy.

LUNG CHANGES during methonium therapy.


TOLBUTAMIDE in diabetes.

TOLBUTAMIDE in diabetes.


PNEUMOCONIOSIS in coal workers.

PNEUMOCONIOSIS in coal workers.


MEASURE to maid.

MEASURE to maid.


Habitual abortion due to insufficiency of the internal cervical os.


Polytetrafluorethylene films in baking.

Polytetrafluorethylene films in baking.


Speed warning device.

Speed warning device.


Familial ulcers, mutilating lesions of the extremities, and acro-osteolysis.


Peripheral artery grafting; description of an operation.


Toxaemia of pregnancy treated with progesterone during the symptomatic stage.


Liquor amnii studies in the prediction of haemolytic disease of the newborn.


Lactation and heredity.

Lactation and heredity.


Pneumonia and bronchial vesiculation associated with herpes zoster, with reference to other visceral associations of zoster.


Prolonged labour; a clinical trial of continous caudal analgesia.


Antihaemophilic globulin deficiency associated with a capillary defect.


Influence of high-protein diets on liver-function tests in kwashiorkor.


Congenital haemolytic anaemia complicated by megaloblastic anaemia of pregnancy.


Subcutaneous emphysema occurring after labour.


PERIODIC disease.

PERIODIC disease.


PROSTITUTION.

PROSTITUTION.


TROPHIC lesions in nervous disease.

TROPHIC lesions in nervous disease.


SANITATION and poliomyelitis.

SANITATION and poliomyelitis.


PINK DISEASE.

PINK DISEASE.


A standard diathermy cystoscope.

A standard diathermy cystoscope.


Medicinal treatment:  its aims and results.


Sudden loss of memory.

Sudden loss of memory.


Hypopituitarism with consecutive development of diabetes mellitus.


Cat-scratch disease.

Cat-scratch disease.


Coarctation of aorta presenting as cardiac failure in early infancy.


Polyposis of gastro-intestinal tract:  the Peutz syndrome.


Cat-Scratch disease with pneumonia.

Cat-Scratch disease with pneumonia.


Primary torsion of the greater omentum in childhood.


Perforation of gall-bladder during prednisone treatment.


Treatment of acute primidone poisoning with bemegride and amiphenazole.


Acute epidemic myalgia of the hip.

Acute epidemic myalgia of the hip.


PALLIATIVE radiotherapy.

PALLIATIVE radiotherapy.


PROOF of harmlessness.

PROOF of harmlessness.


THE RHESUS puzzle.

THE RHESUS puzzle.


LUNG CANCER in women.

LUNG CANCER in women.


ANTIBIOTICS in chronic bronchial infection.


Rh notation.

Rh notation.


R.A. KERR.

R.A. KERR.


A surgery conversion for four doctors.

A surgery conversion for four doctors.


[Filling of experimental bone cavities with plastic chips].


[World famine or the future bread war].

[World famine or the future bread war].


The challenge of pain syndromes.

The challenge of pain syndromes.


The role of pleural biopsy in the study of patients with pleural effusions.


Bilateral axillary polymastia:  report of a case.


Induced immediated hypersensitivity to purified protein derivative tuberculin (PPD).


Polycythemia associated with renal tumors.


Hitherto undescribed characteristics of the pathology of infantile cortical hyperostosis (Caffey's disease).


An assay of the skeletogenic effect of L-triiodothyronine and its acetic acid analogue in immature rats.


The neurology of affect.

The neurology of affect.


Further observations on thoracic disk protrusions.


Alcoholic motor polyneuritis.

Alcoholic motor polyneuritis.


Paralysis of the legs in sedentary workers; a preliminary report.


Stab wounds of the spinal cord; report of three cases.


Congenital syphilis as a cause of mental deficiency.


Early symptoms of multiple sclerosis; a survey of eighty-two cases.


A decade of medical historiography.

A decade of medical historiography.


Outstanding acquisitions of rare books in medical libraries of the United States in the last decade.


Snapshot of the medical librarian as historian and bibliographer, to 1947.


Some American medical imprints of the nineteenth century.


Nurse heroines of the Confederacy.

Nurse heroines of the Confederacy.


Medical book societies in England in the eighteenth and nineteenth centuries.


Events in the development of education for medical librarianship in the last decade.


Medical reference sources; a backward glance.


Dental, nursing and pharmaceutical libraries, 1947-1957.


The Medical Library Association, 1947-1957.


Personnel trends of a decade in medical libraries.


The Veterans Administration Medical Library Program, 1946-1956.


Research and medical librarianship.

Research and medical librarianship.


Management improvement in the library.

Management improvement in the library.


National and international pharmacopoeias:  a checklist.


Parental anxieties accompanying sleep disturbance in young children.


The meaning of external control to a schizophrenic adolescent girl.


Opening phase in the psychotherapy of adolescents with character disorders.


PROBLEMS of infectious diseases and their therapy in the aged.


The surgery of acquired heart disease.

The surgery of acquired heart disease.


Medicolegal aspects of infection.

Medicolegal aspects of infection.


A note on determination of transaminase activity in bloody cerebrospinal fluid.


Our distinguished honorary alumnus; Ephraim McDowell.


OBSTETRIC case report.

OBSTETRIC case report.


DR. MAURICE C. PINCOFFS honored at testimonial dinner.


Assay for epinephrine and nor-epinephrine.


Phosphorylation and dephosphorylation in relation to glucose transport.


Renal transport mechanisms.

Renal transport mechanisms.


Enchancement of hexobarbital hypnosis.

Enchancement of hexobarbital hypnosis.


The bacterial neurotoxins; a key to pharmacologic specificity.


Hemicholinium:  a new aid in the study of cholinergic mechanisms.


TULANE profile:  Dr. Fred W. Schueler.

TULANE profile:  Dr. Fred W. Schueler.


Observations on kwashiorkor or protein undernutrition in Rangoon.


Epidemiology studies and the pathology of communities.


Mental health as a public health problem.


Food is good for you.

Food is good for you.


Physical trauma as a cause of acute pancreatitis.


Myocardial infarction in Rangoon.

Myocardial infarction in Rangoon.


Role of nutrition in disease.

Role of nutrition in disease.


The cancer-diagnostic potential of uterine exfoliative cytology.


The uterine-cytology program of the American Cancer Society.


Postoperative-postanesthetic recovery rooms; a report on three years of experience. An analysis of the three-year experience of the recovery room at the Cedars of Lebanon Hospital emphasized the importance of this phase of postoperative care. Closer observation and supervision of the patient is provided during a critical period, and specialized nursing care is constantly available. Supportive and corrective therapy can be carried out immediately by the cooperative efforts of the anesthesiologist and surgeon, who are close by. The completely equipped and properly staffed recovery room is the best assurance for reducing postoperative morbidity and mortality.


Etiological mechanisms and classifications of headaches.


Poliomyelitis; effect of Salk vaccine on severity of paralysis. The severity of paralysis in 642 nonvaccinated patients with poliomyelitis and in 93 vaccinated patients was observed at the Los Angeles County General Hospital in 1956. In the vaccinated group of patients the proportion of nonparalytic and mild paralytic cases was consistently greater in each 5-year age group under age 15 than in the nonvaccinated. In the entire 0 to 14 age bracket, 12 per cent of the vaccinated patients had moderate or marked degrees of paralysis as compared to nearly 50 per cent of the nonvaccinated cases. There were too few vaccinated patients for comparison over this age. In the vaccinated group as a whole there was no apparent difference in severity as between patients who had had one inoculation and those who had had two. Among the small number of vaccinated patients under age 5, however, there was a suggestive decrease in severity between patients with one and with two inoculations. In nonvaccinated patients, the disease tended to be most severe in the 0 to 4 age group and young adults, ages 20 to 35. The largest number of deaths and of cases in which a respirator was needed occurred among young adults. None of the vaccinated patients died or needed a respirator, but tracheotomy was necessary for three. The concentration of mild cases in the vaccinated group is believed to indicate that partial protection was conferred by the vaccine, resulting in a shift to lesser degrees of severity. Such a shift would obscure the conversion of nonparalytic cases to inapparent infections. Convalescent follow-up examinations of 62 vaccinated and 68 nonvaccinated patients mostly in the 5 to 9 age group, revealed that in both series of patients approximately 90 per cent of the muscle groups graded as having "slight paralysis" at the time of discharge, were nonparalytic on the later examination.


Migraine and tension headaches.

Migraine and tension headaches.


Cosmetic rhinoplasty.

Cosmetic rhinoplasty. Rhinoplasty is safe, relatively painless and, if patients are carefully selected, quite successful. Psychological and personal benefits amply justify the procedure. Frequent indications are feelings of social rejection or ridicule and racial discrimination. Psychoneurotic patients with severe complexes, however, are poor subjects for rhinoplasty and should not be operated upon. It is doubtful that rhinoplasty grossly changes the physiologic integrity of the nose. Psychological trauma to the patient during hospitalization is to be avoided, sedation properly gauged for each patient, and complete block anesthesia used to preserve the cough reflex. The operation is brief and a small splint is worn for a few days. Complications are rare.


Mitral or aortic commissurotomy; criteria for selection of patients. IN THE SELECTION OF PATIENTS FOR MITRAL COMMISSUROTOMY, FIVE SEPARATE CATEGORIES ARE TO BE CONSIDERED: (1) true mitral block with small heart and high pulmonary artery pressure, (2) mitral stenosis without mitral block, (3) mitral stenosis with subacute carditis, (4) mitral stenosis with marked cardiac hypertrophy, and (5) mitral stenosis with embolism. Surgical results are good to excellent provided adequate preoperative evaluation has eliminated the groups with subacute carditis, and those without mitral block. Cardiac catheterization is a valuable adjunct in difficult problems.


Multiple sclerosis; failure of treatment with orally administered digestive enzymes. A series of patients with multiple sclerosis, most of whom had had the disease a long time, had no clinical response to therapy with a protein enzyme preparation (Entozyme(R)) over a period of 12 to 24 months. They did, however, show an improvement in the chylomicron index and in albumin concentration in the blood serum.


Giant cell tumor-like lesions of bone; a preliminary report of a pathological entity. In three cases of a giant cell tumor-like lesion of bone, the histological characteristics of the lesions were a fibrogenic stroma, capillaries, thick-walled blood vessels, multinucleated giant cells, osteoid tissue and bone trabeculae. It is believed that tumors of that kind are another giant cell variant that should be separated from the true giant cell tumor if for no other reason than the favorable response to conservative surgical therapy.


Subacute cerebellar degeneration associated with bronchogenic carcinoma.


Intramedullary hemangioma of the spinal cord.


Bundle branch block in a patient with infectious mononucleosis.


Migration of bullet in gunshot wound of the brain.


Peripheral arteriosclerosis; arterial grafting procedures; indications and results.  I.  Arteriosclerotic aneurysms. In 32 cases aneurysms of the aorta and peripheral arteries were resected and replaced by grafts. The results from the use of homografts in 18 cases were more satisfactory than with the use of Ivalon in 14 cases. The abdominal aorta was the most frequent location of aneurysms. The current mortality rate of 5.5 per cent for resection of unruptured abdominal aneurysms indicates that resection and grafting are an effective means of reducing the high mortality of untreated aneurysms. Five ruptured aneurysms were excised, with a mortality rate of 40 per cent. The uniformly fatal outcome of untreated ruptured abdominal aneurysms makes it obligatory for the surgeon to operate immediately after the diagnosis is first made.


Emotional problems in children; the uses of drugs in therapeutic management. Emotional disturbances in children may be due to an anxiety state, to obsessive-compulsive neurosis, to schizophrenia or to a brain injury causing a behavior disorder. Children in an anxiety state have difficulty in school because anxiety interferes with concentration, impairs memory and makes decisions difficult. Consequently, these children often fear school and express their anxiety by behavior disturbances which alienate them from parents and teachers. There are a number of chemotherapeutic agents physicians can use as a part of the treatment of emotionally disturbed children. Phenobarbital is valuable for short-term therapy for the anxious child. Meprobamate also may be prescribed for anxiety reactions. It is of limited value for the hyperkinetic and obsessive-compulsive child and of no value in the schizophrenic child. Atarax (hydroxyzine dihydrochloride) is beneficial for the neurotic and hyperkinetic brain-injured child. Children with severe anxiety reactions and schizophrenic disorders respond best to chlorpromazine or reserpine.It must be emphasized that drug therapy is a part of the total therapeutic attack on the emotional problems of children.


Subjective compliants in industrial injuries. Subjective complaints that are actually disabling are ratable factors in industrial injury cases in California. The responsibility of evaluating these complaints with fairness to the patient and employer rests with the examining physician. Full confidence in the physician's integrity minimizes the subjective complaint problem. The importance of good physician-patient relationship is not always recognized.


Work injury:  a second look at the doctor's first report. Injured employees require medical care and, if disabled, compensation payments for subsistence. The law requires that the employer or insurance carrier supply these benefits promptly. In the absence of prompt and adequate information from the attending physician, these benefits are withheld. The necessary information required to process employee's claim is that called for on the standard accident report form, commonly called the "pink slip." Not to supply this minimum information may constitute a hardship on the employee. By supplying more elaborate information than that called for, the physician may be increasing his load of "paper work" immeasurably.


Workmen's compensation; details of medical reports. Attention to details of medical reporting that are required for just settlement of compensation cases can greatly facilitate proper adjudication.


Gas cysts of the intestine; report of a case.


Disability; is it permanent?

Disability; is it permanent? Too often cases of industrial injuries are submitted for permanent disability rating before maximum recovery is attained and the condition is permanent and stationary. This is frequently a situation that is detrimental to the injured working man, since his physical disability might be further reduced by additional treatment, and his future earning power and economic status thus be improved. Also it may be detrimental to the insurance carrier and/or employer, since in some instances it results in increased permanent disability award payments for portions of the condition which are not truly permanent. Inadequate medical reports also are a frequent cause of unfair awards. The necessary factors used to arrive at proper conclusions, the errors that have been observed and the importance of this problem are discussed.


Loss of blood at operation; a method for continuous measurement. A method for continuous measurement of surgical blood loss has been devised and has been used clinically in some 400 cases. The method combines volumetric measure of the suction loss and gravimetric measure of the sponge loss. The volumetric device automatically deducts the volume of rinse water used and thus measures the amount of blood collected in a metering cylinder. The suction loss scale shows continuously the amount of blood in the metering cylinder. The gravimetric device requires counting sponges into the weighing pan, and turning a dial scale to deduct the initial weight of the sponges. The volume of blood in the sponges is then read directly on the dial scale. Use of the instrument, which is under the supervision of the anesthesiologist, adds about two minutes per hour to the time normally required for counting the sponges; and about three minutes per hour is required for tending the volumetric instrument.In clinical use, knowing constantly the amount of blood loss permits the starting of transfusion before serious deficit develops, and then maintaining the patient's blood volume at a predetermined optimum level. In some 400 cases the continuous measurement of the blood loss served as a reliable guide for carrying out the loss-replacement plan within close limits of accuracy.


Extracutaneous manifestations of Kaposi's sarcoma:  a systemic lymphoblastoma. Kaposi's sarcoma may affect any system of the body. Serious difficulties occur only when the heart, lungs or gastrointestinal tract are affected. Usually, involvement in other viscera causes no clinical symptoms.This neoplasm is thought to be a low-grade lymphoblastoma. This idea of relationship is based on clinical and histologic association of Kaposi's sarcoma with the lymphoblastomas more commonly than would be anticipated from the rarity of the conditions under consideration. This concept is strengthened by the occasional seeming mutation of Kaposi's sarcoma into a lymphoblastoma. The associated reticuloendothelial hyperplasia in Kaposi's sarcoma is another link in the evidence of relationship.


The use of a medical interviewer; an assistant who saves the physician time and the patient money. For dealing economically yet effectively with patients who are being made sick by psychic burdens rather than by "simple" organic disease, a trained interviewer who follows a formal outline in obtaining information from patients, can be of great assistance. The physician who makes use of the services of such an interviewer should select a person with good qualifications for the job and then train her for it. It is also up to the physician to get the patient to accept the idea of interview by such an assistant. After the interview, the interviewer prepares a typewritten summary for the physician for use as a guide in discussing means of treatment and prevention of psychosomatic illness with the patient. The method saves the physician much time, the patients much money, and has resulted in many gratifying therapeutic successes.


Hemotherapy in suscepted dermatomyositis.


Diffuse cavernous hemangioma of the rectum and rectosigmoid.


Toxic bite of a spider, Cheiracanthium inclusum Hentz.


Professional liability problems in the past:  the Graves malpractice case.


FAR EAST type influenza in California.

FAR EAST type influenza in California.


THE TEACHING of anaesthesia.

THE TEACHING of anaesthesia.


OCCUPATIONAL health programs.

OCCUPATIONAL health programs.


Clinical evaluation of fluothane with special reference to a controlled percentage vaporizer.


Evaluation of fluothane for clinical anaesthesia.


Clinical experience with fluothane, a new non-explosive anaesthetic agent.


Fluothane for paediatric anaesthesia.

Fluothane for paediatric anaesthesia.


An attempt to correlate the clinical signs of fluothane anaesthesia with the electroencephalographic levels.


Heart sounds during fluothane anaesthesia.


The use of fluothane in anaesthesia for neurosurgery:  a preliminary report.


The hospital's role in society.  II.

The hospital's role in society.  II.


Changing responsibilities in public health.


A symposium:  recent renovations and additions at Women's College Hospital.


Buthalitone sodium anaesthesia:  drug consumption and serum protein studies.


Paralytic poliomyelitis incidence as a guide to vaccination.


Where are we going with dental health programs?


Postgraduate teaching in public health in the University of Toronto, 1913, 1955.


Problems of packaged, ready-to-eat, meat products.


The physiological effects of intravenous anaesthesia on man.


Internal mammary node biopsy:  its place in the treatment of breast carcinoma.


Intra-epithelial carcinoma of the cervix, 214 cases, with emphasis on investigation by cytology and cone biopsy.


The shoulder-hand syndrome:  historical review with observations on seventy-three patients.


Haemolytic disease of the newborn due to ABO isoimmunization.


The vicious circle of anaemia and menorrhagia.


The cellular changes in myocardial infarction.


The reversibility of atherosclerosis.

The reversibility of atherosclerosis.


1000 Cases of tonsillectomy in a prepayment plan:  preoperative and postoperative history.


Clinical applications of the Funkenstein Test to psychiatric patients.


Studies on a case of thrombocytopathy; experimental findings on the nature of the platelet defect.


A new treatment for resistant pressure sores.


The rehabilitation centre and rheumatic disease.


Western equine encephalomyelitis:  report of a case in Montreal.


Morphological changes in smokers' lungs.


Five hundred cases of pulmonary resection for tuberculosis.


The value of chloroquine in rheumatoid disease:  a four-year study of continuous therapy.


The use of dimenhydrinate as an adjuvant to supportive psychotherapy:  a preliminary report.


New views on muscular tone and relaxation.


Industrial medicine, a new specialty.

Industrial medicine, a new specialty.


An immunological study of the Canadian Indian.


The occurrence of progressive lipodystrophy in mental defectives.


Unexplained cerebellar neuropathy.

Unexplained cerebellar neuropathy.


Post-traumatic Streptococcus Viridans meningitis.


Cat scratch fever:  non-bacterial regional lymphadenitis.


A normal child following insulin coma therapy in early pregnancy.


Malaria in a Saskatchewan-born infant.

Malaria in a Saskatchewan-born infant.


The protective drugs in the treatment of alcoholism.


Rapid cold plasma infusion treatment for severe shock (peripheral failure) following coronary occulsion.


An unusual automobile steering-wheel accident.


Some aspects of the law relating to civil malpractice liability of doctors and hospitals.


VIRUSES and cancer.

VIRUSES and cancer.


Poor posture:  a social, industrial, and medical problem:  with a recitation of the harmful sequelae.


The papers of Dr. Thomas Simpson (1833-1918).


Cobalt 60 beam therapy:  some impressions after five years.


Subacute thyroiditis:  a disease commonly mistaken for pharyngitis.


Increased activity of the coagulation mechanism during alimentary lipaemia:  its significance with regard to thrombosis and atherosclerosis.


Maternal-fetal relationships:  placental transmission of poliomyelitis antibodies in newborn.


Clinical observations on the use of frenquel in the treatment of early schizophrenia.


Experience in the treatment of hypertension with pentapyrrolidinium (ansolysen) in a hypertension outpatient clinic.


The repeat caesarean section:  a study of 616 cases from the Vancouver area.


Acute intraperitoneal perforations of the colon and rectum.


Milkers' nodules.

Milkers' nodules.


The use of thio-tepa (triethylene thiophosphoramide) in melanotic sarcoma.


New forceps for amniotomy for induction of labour.


Emotional factors and rheumatoid arthritis.


Mixed arthritis.

Mixed arthritis.


The Night Centre.

The Night Centre.


Some basic facts about mental defectives.


A crisis in nursing education.

A crisis in nursing education.


Speech therapy.

Speech therapy.


School is a school-is a school.

School is a school-is a school.


The cancer investigator; an evaluation.

The cancer investigator; an evaluation.


Combination therapy of malignant tumors with ionizing radiations and chemicals; a review.


Effect of ethionine on tumor growth, carcass weight, and nonprotein amino acids in the liver of male and female Wistar rats.


Activity and regulation of the serum trypsin-inhibitor in mice.


Structure-activity relationships observed on screening a series of pyrazolopyrimidines against experimental neoplasms.


Dr. Thomas Simpson; 1833-1918; McGill, Med. 1854.


A localized melanoma in a hybrid fish Lebistes x Mollienesia.


Clinical findings in an epidemic of herpangina with myalgic, neurological and gastro-enteritic features.


The challenge of the aging veteran.

The challenge of the aging veteran.


Peptic ulcer in the Canadian Army.

Peptic ulcer in the Canadian Army.


Quantitative biochemical differences between tumor and host as a basis for cancer chemotherapy.  V.  Niacin and 6-aminonicotinamide.


Chemotherapeutic studies with transplants of spontaneous mammary tumors of mice growing in various hosts.


Observations on the action of azaserine in mammalian tissues.


Cytochrome oxidase in the liver of the rat bearing Walker carcinoma 256.


Multiplication of influenza virus in the Ehrlich ascites carcinoma.


Protein-bound azo dye in the liver of hypophysectomized rats.


The metabolism of methylated aminoazo dyes.  VI.  Intracellular distribution and properties of the demethylase system.


The diagnosis of myxoma cordis; diagnosis established pre-operatively in two cases.


The ballistocardiogram of the isolated heart.


Some new concepts in geriatric nursing.

Some new concepts in geriatric nursing.


A note on the absence of auricular fibrillation in the European mole (Talpa europaea).


Observations on myocardial infarction in Israel.


Ballistocardiograph study of mitral valvular disease.


Phonocardiographic investigation of the variability of the first heart sound in auricular fibrillation.


Paroxysmal partial auricular flutter with sinus rhythm.


A clinical analysis of 8063 cases of painless labor by the psychoprophylactic method.


The Sturge-Kalischer-Weber syndrome; a report of four cases.


Cardiac manifestations of the toxic action of potassium antimony tartrate in schistosomiasis patients:  paroxysmal ventricular tachycardia and fibrillation.


Giant myxomatous fibroadenoma of the breast; report of 11 cases.


Ventricular flutter and fibrillation producing Adams-Stokes syndrome following tartar emetic therapy in acute schistosomiasis japonica.


Acute nonspecific pericarditis; a brief review and report of four cases.


Further studies on intussusception in infancy and childhood; a review of 630 cases.


Parasitic invasion of the biliary tract; a report of 140 surgically treated cases.


Heart disease as a cause of death.

Heart disease as a cause of death.


Tricuspid stenosis; physiologic criteria for diagnosis and hemodynamic abnormalities.


Shoulder-hand syndrome following myocardial infarction with special reference to prognosis.


Acute reversible heart failure in Africans.


Disease of the sinoatrial node associated with bradycardia, asystole, syncope, and paroxysmal atrial fibrillation.


Design of an ultra low frequency force ballistocardiograph on the principle of the horizontal pendulum.


Wide frequency range force ballistocardiogram; its correlation with cardiovascular dynamics.


Anomalous connection of right pulmonary veins to superior vena cava with interatrial communications; hemodynamic data in eight cases.


Myocardial sarcoidosis.

Myocardial sarcoidosis.


Effect of protamine on alimentary lipemia.


Cardioaortic fistula; temporary circulatory occlusion as an aid in diagnosis.


Electrocardiographic abnormalities in epidemic hepatitis.


The normal vectorcardiogram and a system for the classification of vectorcardiographic abnormalities.


Syncope as an indication of digitalis toxicity.


Radioactive iodine treatment of angina pectoris and congestive heart failure.


Diagnostic value of translumbar aortography.


Dietary fats and their relationship to atherosclerosis.


Atherosclerosis and the fat content of the diet.


Reversible cardiopulmonary syndrome with extreme obesity.


Association of aortic valvular disease and cystic medial necrosis of the ascending aorta; report of four instances.


Postvalvular stenosis of the pulmonary artery.


Effect of Rauwolfia serpentina and reserpine on the blood pressure in essential hypertension; a long-term double-blind study.


Clinicopathologic correlations of renal biopsies from essential hypertensive patients.


Use of different tissue thromboplastins in the control of anticoagulant therapy.


Serum lipid levels in normal persons; findings of a cooperative study of lipoproteins and atherosclerosis.


Serotonin and antiserotonins.  II.  Clinical studies, especially in essential hypertension with the benzyl analog of serotonin (BAS).


Serotonin and antiserotonins.  I.  Their circulatory, respiratory, and renal effects in man.


Coronary arteries in fetuses, infants, and juveniles.


Amyloidosis of the aorta.

Amyloidosis of the aorta.


SYMPOSIUM on cardiovascular sound.  I.  Mechanisms.


Congestive heart failure.

Congestive heart failure.


The impact of Harvey and his work on circulation research.


Rationale of venous occlusion plethysmography.


Effects of adenine nucleotides on the contractility and membrane potentials of rat atrium.


Quantitation of collagen in human myocardium.


Defibrillatory effects of low sodium solutions on ventricular fibrillation in isolated hearts of rabbits.


Effect of acute fat loads on serum lipids in atherosclerosis.


Absence of vasoactive and cardiotropic substances in coronary sinus blood of dogs.


Mechanism of congestive heart failure following aorta constriction in rabbits.


Functional changes during high output failure produced by daily hemorrhage in dogs with pulmonic stenosis.


A study of circulatory dynamics by means of crystal radiation detectors on the anterior thoracic wall.


Inhibitory effect of isocholesterol on the absorption of cholesterol.


Ventricular arrhythmias induced by sympathomimetic amines in unanesthetized dogs following coronary artery occlusion.


Role of magnesium ion in the initiation of ventricular fibrillation produced by acute coronary occlusion.


Cardiovascular response of the anesthetized hamster to reserpine and ganglionic blockade.


Effect of experimental renal hypertension on experimental thiouracil-cholesterol atherosclerosis in dogs.


Comparison of the intravascular mixing and disappearance of radiosodium, radiopotassium and T-1824.


Capacitive properties of body tissues.

Capacitive properties of body tissues.


Experimental coronary occlusion in dogs and its effect upon the cardiac glycogen fractions.


Role of venous return in the cardiovascular response following injection of ganglion-blocking agents.


Changes in carbohydrate metabolism of cardiac and striated muscle in hypothermic rats.


Effect of synthetic angiotonin on the carotid sinus.


The use of the cervical spread in cancer detection; an effective method and an evaluation.


The hypertension-reducing function of the kidney.


Bronchial adenoma; a clinicopathologic study of 21 cases.


Usefulness of routine serologic tests for syphilis.


Fat-splitting enzymes in blood.

Fat-splitting enzymes in blood.


Studies on the glycerides during the clearing reaction.


A quick method for detection of thallium in urine in cases of poisoning.


Determination of phospholipid fractions in the human erythrocyte.


The mercuric chloride turbidity test.

The mercuric chloride turbidity test.


Gamma globulin levels in normal human serum.


A semi-quantitative method for determination of lithium in small amounts.


An enzymic test for the diagnosis of viral hepatitis; the transaminase serum activities.


The effect of blood anticoagulants on serum and plasma amylase activities.


Research into biochemical factors of inflammation; necrosin (macrocytase) and haemolysin of inflammatory exudates.


The pH-resistance of erythrocytes.  I.  An investigation into the cause of haemolysis.


The splitting of dextran and isomaltose by animal tissues.


Paper chromatography of 56 amino compounds using phenol and butanol-acetic acid as solvents with illustrative chromatograms of normal and abnormal urines.


A stable standard for the colorimetric determination of total protein, albumin, globulin and fibrinogen.


A rapid colorimetric method for the determination of isonicotinic acid hydrazide in blood serum.


The use of dilute alkali in haemoglobinometry.


The effect of heparin on serum esterase in arteriosclerosis.


John Albert Key, 1890-1955.

John Albert Key, 1890-1955.


The structure of bone mineral.

The structure of bone mineral.


The organic matrix of bone and epiphyseal cartilage.


Definitions, terminology and classification of metabolic bone disorders.


The parathyroid hormone and bone.

The parathyroid hormone and bone.


The varieties of rickets and osteomalacia associated with hypophosphatemia.


Developmental affections of the skeleton characterized by osteosclerosis.


Anabolic steroid therapy for the protein depletion and osteoporosis induced corticoid hormones.


Multiple myeloma.

Multiple myeloma.


Some effects of x-rays on bone.

Some effects of x-rays on bone.


Skeletal lesions produced by aminonitriles.


Periosteal myxoma of infancy and periosteal chondroma of adolescence, with local malignancy.


Abnormal ribs in the cervical region associated with Sprengel's deformity.


A destructive lesion involving the intervertebral disk in children.


The management of idiopathic scoliosis.

The management of idiopathic scoliosis.


Wire loop in arthrodesis of the shoulder.


Prosthetics in child amputees.

Prosthetics in child amputees.


Skin grafts in hand surgery.

Skin grafts in hand surgery.


Total excision of semilunar cartilages through a small anterior incision.


Disability following crush fracture of the calcaneus.


Avulsion of the ischial apophysis.

Avulsion of the ischial apophysis.


Ankle fusion in the absence of talar body.


Prevention of accidents.

Prevention of accidents.


Driver proficiency.

Driver proficiency.


Human engineering and automobile safety.


The need for motorcar legislation.

The need for motorcar legislation.


Medical driver screening:  the fourth E of motor-vehicle accident prevention.


Medical aspects of motor-vehicle accident-prevention; study of the driver.


The role of the coroner in motor-vehicle deaths.


Prevention of motoring accidents from the military standpoint.


The role of safety belts in the motorist's safety.


Some orthopaedic aspects of motor-vehicle accidents.


Postmaturity with placental dysfunction.