Studies on the generalized Shwartzman reaction. VIII. The appearance, by electron microscopy, of intravascular fibrinoid in the glomerular capillaries during the reaction. The intravascular fibrinoid which is deposited in glomerular capillaries of the rabbit during the generalized Shwartzman reaction has been studied with the aid of the electron microscope. In one group of animals the reaction was produced by two intravenous injections of Escherichia coli lipopolysaccharide endotoxin, spaced 24 hours apart. In another, a single dose of endotoxin was followed, 1 hour later, by intravenous liquoid (sodium polyanethol sulfonate). The appearance of fibrinoid was the same in the two groups. Initially, fibrinoid deposition occurred on the irregular, swollen surfaces of the endothelial cells within the capillary lumen. Subsequently, the fibrinoid mass increased to such proportions that the capillary lumen was completely occluded. Fibrinoid was found to be composed of unbranched fibrils, having a diameter of 200-300 angstroms and an axial repeating structure of 120 A. The basement membrane (lamina densa) underwent no change in appearance during the time when fibrinoid was being laid down. Balloon-like vesicles were consistently encountered in endothelial cells of glomerular capillaries after two doses of endotoxin, and also in animals given one injection of endotoxin followed by liquoid. The possible significance of the observations are discussed. It is suggested that they are compatible with the hypothesis, proposed earlier, that intravascular fibrinoid, in the generalized Shwartzman reaction, is derived from fibrinogen.


Localization of streptococcal antigens in tissues. I. Histologic distribution and persistence of M protein, types 1, 5, 12, and 19 in the tissues of the mouse. A method has been described for the detection of streptococcal antigens in tissues using the indirect immunofluorescent technique. This method has been applied to the histologic distribution in the mouse of M protein of types 1, 5, 12, and 19. Histologic localization of these M proteins was similar, and their rates of disappearance from the tissues were comparable. The major sites of deposition were the endocardium and adjacent subendocardium of the heart, alveolar walls of the lung, glomerular tufts of the kidney, and reticulo-endothelial cells of liver, spleen, lymph nodes, and adrenal gland. M protein was distributed in considerably lesser concentration in capillary endothelium and connective tissue sites in myocardium, kidney, skin, and gastrointestinal tract. Traces were also present in adrenal cortical cells. It was observed only rarely in cell nuclei. After injection of 0.5 mg. M protein fraction, the concentration of antigen diminished to undetectable levels in all organ sites by 4 days, except in the renal glomerulus, where traces were visible at 8 days. In mice injected with streptococcal culture intraperitoneally, M protein was detected at sites of focal abscesses in liver and spleen, and on the serous surfaces of these organs. The histologic distribution of M protein is compared with that described previously for pneumococcal polysaccharide and animal protein. Differences in the extent of distribution and in the characteristics of antigen deposition are pointed out.


Alterations in the blood coagulation system induced by bacterial endotoxin. I. In vivo (generalized Shwartzman reaction). The intravenous injection of bacterial endotoxins alter the coagulation system of rabbits' blood in vivo. Twenty-four hours after the first injection the fibrinogen level rises to twice normal values. The second injection at this time causes a 30 to 40 per cent decrease in fibrinogen content in 4 hours. Twenty hours later it again rises to twice normal values. A marked decrease in whole blood coagulation times in silicone occurs 4 hours after both injections but rises to normal values 24 hours following each injection. The circulating platelets drop from average levels of 300,000/c.mm. to 150,000/c.mm. after the first injection. The platelets remain at this low level and decrease to less than 100,000 after the second injection. During this time no fibrinolytic or fibrinogenolytic activity can be detected. Also, there is no significant change in the one stage prothrombin times or antithrombin titres. The marked decrease in circulating fibrinogen at the time when intracapillary thrombi are formed suggests that the "hyaline" thrombi of the generalized Shwartzman reaction are composed, in part, of fibrin. There appears to be a relationship between the level of circulating fibrinogen at the time of injection of bacterial endotoxin and the extent of the thrombosis. The higher the preinjection fibrinogen level, the more extensive is the thrombosis. There is also a relationship between the amount of fibrinogen loss and the extent of thrombosis after the injection. The more extensive the thrombosis the greater is the postinjection decrease in circulating fibrinogen. A comparison between the response of the hemostatic mechanism to tissue thromboplastin and bacterial endotoxin indicates that the latter acts in a unique manner and not by way of a simple "thromboplastic" activity. From the hematological standpoint, "preparation" for the generalized Shwartzman reaction is accompanied by an increased circulating fibrinogen, leukocytosis, and thrombocytopenia.


Alterations in the blood coagulation system induced by bacterial endotoxins. II. In vitro. Bacterial endotoxins in vitro are capable of shortening the coagulation time of normal whole blood, native platelet-rich and platelet-poor plasma, and the blood of a hemophilic patient in silicone but not in glass. The point in the coagulation system at which the endotoxins act has not been found but the search has been narrowed by the demonstration that these materials act independently of leukocytes and red blood cells, and do not act as preformed thromboplastin or thrombin. The shortening of the coagulation time in vivo 4 hours after endotoxin injection is probably through a different mechanism than in vitro.


The prevention of the generalized Shwartzman reaction with sodium warfarin. Using intravenous sodium warfarin, rabbits were rendered hypoprothrombinemic and subjected to two intravenous injections of Shear's polysaccharide. None of the 9 animals surviving the required period of time developed bilateral renal cortical necrosis or histologic thrombi in the kidney, liver, spleen, or lungs. In a control group of 7 animals treated only with endotoxin, 6 developed bilateral renal cortical necrosis. It is concluded that the prothrombin complex is necessary for the production of the generalized Shwartzman reaction by bacterial endotoxins and that this phenomenon is essentially a process of disseminated intravascular coagulation.


Studies on the pathogenesis of fever with influenzal viruses. I. The appearance of an endogenous pyrogen in the blood following intravenous injection of virus. A substance with pyrogenic properties appears in the blood streams of rabbits made febrile by the intravenous inoculation of the PR8 strain of influenza A and Newcastle disease viruses (NDV). By means of a technique involving passive transfer of sera from animals given virus to recipient rabbits, the titer of circulating pyrogen was found to be closely correlated with the course of fever produced by virus. Certain properties of the pyrogen are described which differentiate it from the originally injected virus and suggest that the induced pyrogen is of endogenous origin. These properties resemble those of endogenous pyrogens occurring in other forms of experimental fever. The source of virus-induced pyrogen is unknown. In vitro incubation of virus with various constituents of the circulation did not result in the appearance of endogenous pyrogen. Granulocytopenia induced by HN(2) failed to influence either fever or the production of endogenous pyrogen in rabbits injected with NDV. Similarly, the intraperitoneal inoculation of NDV into prepared exudates did not modify the febrile response. These findings do not lend support to the possibility that the polymorphonuclear leukocyte is a significant source of endogenous pyrogen in virus-induced fever. It is concluded that the liberation of an endogenous pyrogen from some as yet undefined source is an essential step in the pathogenesis of fever caused by the influenza group of viruses.


Studies on the pathogenesis of fever with influenzal viruses. II. The effects of endogenous pyrogen in normal and virus-tolerant recipients. Observations have been made on the fever-inducing properties of an endogenous pyrogen found in the circulation of rabbits after the intravenous inoculation of Newcastle disease virus (NDV). When endogenous pyrogen was given to a normal recipient, a biphasic fever was produced which simulated that seen with bacterial endotoxins. With the use of a technique of serial passive transfer, it has been shown that the "double-humped" response results from two separate actions of the injected pyrogen. The first of these appears to be a direct stimulation of the thermoregulatory centers. The second involves the release of further endogenous pyrogen in the normal recipient to cause, in turn, the second fever peak. Since the injection of endogenous pyrogen did not produce a significant change in the number of circulating leukocytes, it is inferred that this substance is different from either bacterial or tissue polysaccharides. In rabbits rendered tolerant by a previous injection of virus the second fever peak failed to appear and the response to endogenous pyrogen was monophasic. Evidence indicates that the absence of a second fever peak in the tolerant recipient was not due to rise in temperature on the preceding day of virus injection or to the development of either serum inhibitors or tolerance to virus itself. It is postulated that prior mobilization of endogenous pyrogen by virus may have modified the ability of the tolerant recipient to liberate further amounts of this substance in response to an injection of endogenous pyrogen.


Studies on the pathogenesis of fever with influenzal viruses. III. The relation of tolerance to the production of endogenous pyrogen. Tolerance to the pyrogenic action of intravenously injected virus has been studied in rabbits given either PR8 strain of influenza A virus or Newcastle disease virus (NDV). The following findings suggest that the capacity of the animal to release an endogenous pyrogen is a critical factor. (a) Viruses produce fever by the release of endogenous pyrogen. (b) Tolerance to the pyrogenic effect of reinjected virus is associated with a decrease or absence of endogenous pyrogen production. (c) Tolerance to virus fever may be induced by the prior injection of endogenous pyrogen. (d) Cross-tolerance has been demonstrated between virus and bacterial endotoxin (typhoid vaccine), both of which cause the release of endogenous pyrogen. A difference has been noted in the mechanism of tolerance to successive injections of virus and of bacterial endotoxin. Repeated injections of endotoxins bring about an accelerated clearance of these substances from the blood stream with the result that there is a diminished stimulus to endogenous pyrogen production. Tolerance to virus, on the other hand, is unaccompanied by changes in the rate at which virus disappears from the circulation. It is postulated that circulating endogenous pyrogen, induced by the injection of a number of pyrogenic agents including viruses, temporarily suppresses the further release of endogenous pyrogen and thereby contributes to virus tolerance.


Irreversible hemorrhagic shock in germfree rats. Evidence has been provided that a state of irreversible hemorrhagic shock can be induced in a bacteria-free environment in rats reared under germfree conditions. The response to bleeding, the duration of the hypotensive episode and the pathological changes were the same in the germfree and in normal stock rats. The findings are interpreted as evidence opposed to the concept that bacteria or bacterial products are implicated, as primary factors, in the pathogenicity of shock.


Studies on the activation of a proesterase associated with partially purified first component of human complement. It has been found that under a wide range of physico-chemical conditions a positive correlation exists between the rate of disappearance of hemolytically active, partially purified first component of human complement and the rate of activation of an esterase hydrolyzing N-acetyl-L-tyrosine ethyl ester. Both reactions follow the kinetic equation for second order autocatalysis, with an apparent energy of activation of 31,000 calories per mol. They occur optimally at pH 7.3-7.7 and are inhibited by ionic strengths greater than 0.15, by 5 x 10(5)M ethylenediaminetetraacetic acid, and by a heat-labile serum inhibitor which appears unrelated to any component of complement. The activation of first component to esterase resembles closely the activation of trypsinogen to trypsin. Partially purified first component, containing plasminogen, may also be activated to esterase by addition of streptokinase. The significance of these data with respect to the postulated existence of first component as a proesterase and its possible role in complement-"fixation" is discussed.


A biochemical and morphologic study of myelination and demyelination. I. Lipide biosynthesis in vitro by normal nervous tissue. Samples of normal grey matter, white matter, and peripheral nerves obtained from rats were incubated in Warburg vessels with glucose and a labelled lipide precursor (acetate, phosphate, choline, glycerol, glucose). The total lipides were then extracted and their radioactivity measured. The preparations were compared with respect to dry weight, lipide content, O(2) uptake, and ability to incorporate the various substrates into the lipides. Grey matter was found to be the least damaged by incubation, white matter the most. Damage to the tissue depressed lipogenesis to a greater extent than respiration. Five substrates were compared with respect to their degree of incorporation into the lipides of the various preparations. White matter, which had a greater oxygen uptake than peripheral nerves, showed the lowest degree of incorporation for most of the substrates studied. The results suggest that there are considerable quantitative differences in the metabolism of central and peripheral myelin. In the sciatic preparations, oxygen uptake and lipogenesis from acetate were found to decrease from the proximal to the distal end of the nerve. This finding may be relevant to the pathogenesis of peripheral neuropathies. The growth and metabolic activity of peripheral nerves were studied in rats aged 1 to 500 days, and the biochemical and histological findings were correlated. The results indicated that the lipogenetic activity of the Schwann cell was lowest in the newborn animal, and reached its peak at about 20 days. Comparative data were also obtained from the cerebral cortex. The growth pattern of peripheral nerves was distinctly different from that of the brain. With respect to changes in tissue weight, respiration, and lipogenesis, growing peripheral nerve correlated with body weight, while the brain matured much more rapidly.


Effect of secondary injections of antigen upon the retention in liver of a primary injection. The retention of antigen in rabbit liver tissue, resulting from a primary intravenous injection, is influenced by immunization brought about by subsequent intravenous injections of the same antigen. In rabbits given a single primary intravenous injection of radioactive antigen, the retention of radioactivity in liver tissue, after a period of 21 days, was greater than when the primary injection was followed by secondary injections of the same, but non-radioactive antigen. The results were similar for both S(35)-azohemocyanin and S(35)-azo-bovine-serum-albumin, except the hemocyanin was retained to a greater extent than the albumin. There was very little if any correlation between the number of secondary injections and retention of the initial injection. Quantitative antibody nitrogen data, obtained for the serum of each rabbit showed, in general, an inverse relationship between circulating antibody and radioactivity retained, i.e. the higher the circulating antibody titer, the lower the retention of radioactivity in liver tissue. Passively administered homologous antibody did not produce a change in the retention of the primary injection of antigen nor did secondary injections of a heterologous native protein injected according to the same immunization schedule as the homologous azoprotein. From these results it may be concluded that an intracellular antibody-forming activity influences the loss (or retention) of antigen deposited in liver tissue and that the mechanism is immunologically specific.


Colominic acid, a polymer of N-acetylneuraminic acid. All acidic carbohydrate has been isolated from the culture medium of the enteric microorganism E. coli K(235) L(+)O. This substance has been named colominic acid. N-acetylneuraminic acid, which has been isolated from the hydrolysate of colominic acid, is believed to be the monomer unit from which colominic acid is constituted. Colominic acid is not antigenic in rabbits. Tests have failed to reveal a relationship between the ability of E. coli K(235) to elaborate colominic acid and its virulence in mice.


The effect of bacterial constituents on the resistance of mice to heterologous infection and on the activity of their reticulo-endothelial system. Administration of small amounts of salmonella endotoxin (20 microg.) or of acetone-extracted BCG cells (100 microg.) increases the resistance of mice to infection with Myco. fortuitum as well as their ability to clear carbon particles from their blood stream. Whereas the increased resistance to infection persists for many weeks, the clearing power returns to a normal level within a few days. When normal mice are infected with Myco. fortuitum, there occurs during the first phase of the infectious process a rise in clearing power for carbon particles followed by a fall during the terminal phase of the disease. The rise occurs more rapidly and is more pronounced in animals previously treated with salmonella endotoxin or with killed BCG cells. This acceleration and intensification of the phagocytic response to infection can be detected even in animals which exhibit a normal phagocytic index when tested several weeks after administration of endotoxin or of BCG. Although increase in resistance to infection is correlated with activation of the so called reticulo-endothelial system, there is no evidence of any direct causal relationship between the two phenomena.


Studies on antibody synthesis initiated in vitro. Ten microg. of the lipopolysaccharide endotoxin of Salmonella typhosa was given to rabbits intravenously to enhance the subsequent antibody response to an unrelated substance. The spleens were removed 24 hours later, diced, and incubated 1 hour with the antigen, bovine-gamma-globulin (BGG), in a protein-free medium. After washing, the tissues either were extracted at once or planted and the fluids and tissues harvested 1 to 3 days later. Antibody was determined by a modification of the Boyden hemagglutination technique. Small amounts of antibody were synthesized as early as 1 hour after the addition of antigen. The antibody formed could be specifically inhibited with BGG, was not dialyzable, and did not sediment at 105,000 g for 2 hours. Dose-response studies revealed no antibody formation when the BGG concentration was 0.005 or 0.05 mg./ml. The best responses were obtained at concentrations of 0.5 to 5.0 mg./ml. These results were found irrespective of whether the animal had previously received BGG in vivo. Forty per cent autologous serum increased antibody formation about 9-fold over that secured with protein-free medium or with 40 per cent homologous serum. Antibody formed with this system could be detected by 50 per cent complement fixation test, although at much lower titer than found by hemagglutination. While spleens from rabbits previously given BGG did not produce more antibody than spleens from normal rabbits, they differed in that they produced antibody without the involvement of endotoxin. Under appropriate circumstances, endotoxin was effective in vitro in enabling spleen fragments to produce antibody to BGG. Cortisone acetate administered to rabbits prior to the removal of the spleen severely inhibited antibody production in vitro. Sodium prednisolone phosphate added in vitro showed a similar irreversible effect at concentrations as low as 2 x 10(-5)M. Nitrogen mustard inhibited antibody formation at concentrations as low as 10(-4)M.


Studies of pupillary conditioning.

Studies of pupillary conditioning.


Backward associations in transfer and learning.


Blood pressure, cholesterol content of serum and tissues and atherogenesis in the rat. Rats on a stock diet with added cholesterol, cholic acid, and thiouracil developed increased concentrations of cholesterol, total lipide, and beta lipoprotein in the serum, and an increased content of cholesterol in the liver and carcass, despite the fact that the diet produced a cessation of endogenous cholesterol synthesis. Rats with high serum lipide concentrations developed intimal lesions similar to those of human atherosclerosis. The induction of hypertension by desoxycorticosterone and salt accelerated the development of hypercholesterolemia, hyperlipemia, increase in tissue cholesterol content, and atherosclerotic changes in the intima. Hypertension induced by renal artery constriction also intensified the hypercholesterolemia and hyperlipemia. On the other hand, rats receiving desoxycorticosterone acetate without salt or salt without desoxycorticosterone acetate did not show any intensification of hypercholesterolemia or hyperlipemia. The extent of the atherosclerotic lesions was correlated with the concentration of cholesterol in the serum. There was also a positive correlation between blood pressure and the degree of hypercholesterolemia. It remained uncertain whether the increase in atherosclerosis in the hypertensive animals was dependent on the increased lipide content of serum and tissues or on a local effect of the elevated blood pressure.


Studies on bacteriemia. IV. Alterations in rabbit mortality associated with aging of a culture of Escherichia coli. Rabbits given an intravenous injection of an 18 to 24 hour broth culture of E. coli commonly died within 28 hours. The injection of a 4 hour broth culture of the same strain of E. coli containing equal numbers of living bacilli produced only an occasional death. Initial clearance rates and subsequent bacteriemias were similar in animals receiving either culture. Study of changes in circulating leukocytes or the temperature response to washed bacterial cells or culture filtrates failed to reveal obvious differences in host response to young or old cultures. It was found that both living bacterial cells and some substance or substances present in culture filtrates were required to produce subsequent death. The injection of whole old cultures containing both these factors produced hypothermia instead of the endotoxin type fever response which followed the injection of whole young cultures. Subsequent experiments revealed that this hypothermia appeared to be secondary to a period of transient but profound shock which occurred soon after the injection in rabbits receiving old cultures. No significant alterations in arterial pressure accompanied injections of young cultures. Evidence is presented which suggests that this period of hypotension rendered animals more likely to die with a persisting bacteriemia tolerated without event by non-shocked animals. The mechanisms which operate to increase mortality during the post shock period are as yet unclarified.


Probability learning under equivalent data collection methods.


Expectation and resistance to extinction of a leverpulling response as a function of percentage of reinforcement and number of acquisition trials.


Effects of mediated associations on transfer in paired-associate learning.


Transfer effects from a single to a double integral tracking system.


Some information aspects of form discrimination.


Assimilation and contrast effects of anchoring stimuli on judgments.


Cytological aberrations in cultures of normal monkey kidney epithelial cells. A cytological study was made of short term primary cultures of monkey kidney epithelial cells grown in serum-containing (M-H) and synthetic (SM-2) media. The mitotic activity of the cultures reached a peak 3 to 5 days after seeding, and rapidly declined if the medium was not changed. With replenishment at 48 hour intervals a high mitotic rate was maintained through the 8th day. Cultures subjected to a glycine- and glucose-deficient medium showed a sharp decline in mitotic activity within 24 hours. When such cultures were replenished a burst of mitotic activity occurred 20 to 30 hours later. Mitotic aberrations such as multipolar spindles, anomalous spindles with scattered chromosomes, lagging or precocious movement of chromosomes, chromosome fragments, and chromosome bridges were found in all cultures ranging from 16 to 40 per cent of the dividing cells. Non-mitotic aberrations such as giant nuclei, multinucleate cells, nuclear fragmentation, micronuclei, nuclear inclusions, and phagocytosis were found in approximately 3 to 7 per cent of the non-dividing cell population. The frequency and types of mitotic abnormalities were generally independent of the medium used and the mitotic index of the cultures.


Achievement drive and habitual modes of task approach as factors in skill transfer.


Influence of task complexity and instructions upon simple and discrimination reaction times.


Effects of task difficulty, stimulus similarity, and type of response on stimulus predifferentiation.


Motor conflict behavior as a function of motivation and amount of training.


Perceptual efficiency as related to induced muscular effort and manifest anxiety.


Evidence that the secondary reinforcing stimulus must be discriminated.


Muscle responses and their relation to rote learning.


Cue and contextual stimulus intensity in discrimination learning.


Shifts in connotative meaning of words as a function of previous restrictive experience.


Inferential behavior in children. I. The influence of reinforcement and incentive motivation.


Pre-extinction in sensory preconditioning.


Context effects with judgmental language that is absolute, extensive, and extra-experimentally anchored.


Time sharing between frequency-coded auditory and visual channels.


A correlational study of two reasoning problems.


Eyelid conditioning as a function of unconditioned stimulus intensity and intertrial interval.


Verbal and motor responses to seven symbolic visual codes: a study in S-R compatibility.


Permanent satiation phenomena with kinesthetic figural aftereffects.


Transfer to a motor task as influenced by conditions and degree of prior discrimination training.


Retention in motor learning as a function of amount of practice and rest.


Acquisition and extinction of problem-solving set.


Concept formation as a function of competition between response produced cues.


Time-order errors in comparative judgments of hurtfulness.


The influence of complexity and novelty in visual figures on orienting responses.


Interaction between total stimulus information and specific stimulus information in visual recognition.


Supplementary report: effect of addition of irrelevant verbal cues on perceptual-motor learning.


A reconsideration of nitrogen excretion by the chick embryo.


Regeneration of iris and lens in hypophysectomized adult newts.


The influence of denervation upon traumainduced regenerates of the forelimb of the postmetamorphic frog.


Deletion experiments on the oral primordium of Stentor coeruleus.


Further experiments on lens regeneration from retina pigment cells in adult newt eyes.


Studies on nerve regeneration in Periplaneta americana.


Specificity of embryonic response to chemical inhibitors.


The effects of P32 on mitosis in tail-tips of larval salamanders.


The effects of heavy gamma irradiation upon pituitary glands transplanted into hypophysectomized tadpoles of bufo boreas.


Oxidative metabolism and seasonal variations in the incidence of perocephaly of chicken embryos.


Facial fractures: their recognition and management.


Recurrent intussusception in a six year old child with histoplasmosis of Peyer's patches.


Diabetes screening in Polk County.

Diabetes screening in Polk County.


Hiccups as sole presenting symptom of myocardial infarction.


The risk of ascaris infestation from the use of human sludge as lawn fertilizer.


Improved results in the postcoital test with terramycin vaginal suppositories.


Blue Shield yesterday, today and tomorrow.


My view of Flordia Blue Shield.

My view of Flordia Blue Shield.


The postspike positivity of unmedullated fibers of dorsal root origin. The positivity following the spike in the action potential of unmedullated nerve fibers of dorsal root origin (d.r.C) has been shown to be homologous with the first positive potential (P(1)) of other varieties of nerve fibers. Thus it is only through the large size of the positivity that this group of nerve fibers is set apart from other groups. New findings accentuate and make more explicit the difference of d.r.C fiber behavior from that of the sympathetic unmedullated fibers. Support of the conclusion is derived from re-examination of the A fibers as well as from observations on the d.r.C fibers. Increase in size of the P(1)'s in a tetanus of the d.r.C fibers can occur if the frequency is high enough; and it does not occur in an A fiber tetanus if the frequency is low enough. Frequency is also critical in the obtainment of increasing P(1)'s in a tetanus of sympathetic C fibers. Decrease in the size of the P(1)'s in the course of a tetanus is attributable to development of the negative after-potential (N a-p). In rested d.r.C fibers the N a-p is latent. But it appears during a tetanus, develops in size, and after the tetanus leads to a long lasting and clearly defined second positive potential. Absence of a supernormal period during the N a-p of the d.r.C fibers is accounted for. An analysis is made of the apparent increase in size of the spike elevations during a tetanus, for the two subgroups of the C fibers. The difference between the after-potentials of A fibers and of sympathetic C fibers is correlated with the shapes of the curves of cathodal electrotonus of these fibers.


Propagated repolarization in heart muscle. The effect of current flow on the transmembrane action potential of single fibers of ventricular muscle has been examined. Pulses of repolarizing current applied during the plateau of the action potential displace membrane potential much more than do pulses of depolarizing current. The application of sufficiently strong pulses of repolarizing current initiates sustained repolarization which persists after the end of the pulse. This sustained repolarization appears to propagate throughout the length of the fiber. Demonstration of propagated repolarization is made difficult by appearance of break excitation at the end of the repolarizing pulse. The thresholds for sustained repolarization and break excitation are separated by reducing the concentration of Ca(++) in the environment of the fiber. In fibers in such an environment it is easier to demonstrate apparently propagated repolarization and also, by further increase of the strength of the repolarizing current, to demonstrate graded break excitation.


A zone phenomenon and a progressive reaction occurring with a radioactive hemolysin, sodium erucate, I 131. Sodium erucate reacts progressively (i.e., once the reaction is started in a time which is so short that the lysin is in contact with the red cells for 30 seconds, it cannot be stopped even by being diluted 10-fold) with human red cells at pH 7. At the same time, systems containing the lysin and human red cells show a zone phenomenon, lysis occurring most readily in a certain concentration of lysin but more slowly in larger or smaller concentrations. Sodium erucate-I(131) can be used to investigate both the zone phenomenon and the progressive character of the reaction. As regards the former, large concentrations of the lysin react relatively poorly with the red cell surfaces and the resistance of the red cells is relatively high. This may be due to the presence of an admixed inhibitor or to the development of an inhibitory state. The lysin is taken up and fixed by material in the red cell surface, so that the "internal phase" of lysin attached to the cell surfaces is so firmly fixed that a 10-fold dilution has no effect on it. It follows that lysis in these systems is progressive, as it is found to be.


Active sodium transport by the isolated toad bladder. Studies were made of the active ion transport by the isolated urinary bladder of the European toad, Bufo bufo, and the large American toad, Bufo marinus. The urinary bladder of the toad is a thin membrane consisting of a single layer of mucosal cells supported on a small amount of connective tissue. The bladder exhibits a characteristic transmembrane potential with the serosal surface electrically positive to the mucosal surface. Active sodium transport was demonstrated by the isolated bladder under both aerobic and anaerobic conditions. Aerobically the mean net sodium flux across the bladder wall measured with radioactive isotopes, Na(24) and Na(22), just equalled the simultaneous short-circuit current in 42 periods each of 1 hour's duration. The electrical phenomenon exhibited by the isolated membrane was thus quantitatively accounted for solely by active transport of sodium. Anaerobically the mean net sodium flux was found to be slightly less than the short-circuit current in 21 periods of observation. The cause of this discrepancy is not known. The short-circuit current of the isolated toad bladder was regularly stimulated with pure oxytocin and vasopressin when applied to the serosal surface under aerobic and anaerobic conditions. Adrenaline failed to stimulate the short-circuit current of the toad bladder.


A modified capillary microrespirometer.

A modified capillary microrespirometer. Modifications which enable simpler operation of the Cunningham-Barth-Kirk microrespirometer are described and an example of its use is quoted. Added advantages include easy positioning of indicator drop in the capillary and thermal equilibration at atmospheric pressure.


A statistical analyzer for optic nerve messages. A statistical mathematical model of the discharge in a single optic nerve fiber is proposed, based on a discharge with intervals between impulses distributed independently according to a gamma distribution ("gamma discharge"). A light stimulus distorts the time axis of this discharge according to a "frequency function" which is characteristic of the stimulus. A linear filter is described which calculates the likelihood of a certain stimulus when the nerve fiber message is fed into it. This filter forms the basis of theoretical nerve message analyzers for three visual experiments: (a) The detection of the occurrence of a flash of light of known intensity and time of occurrence, (b) the detection of the time of occurrence of a flash of known intensity, and (c) The estimation of the intensity of a flash occurring at a known time. Possible neural mechanisms in the brain for analyzing optic nerve messages, based on the above mathematical models, are suggested. Changes of excitability or discharge frequency correspond to the output of the likelihood filter. Any such mechanism must be sufficiently plastic to have a response matched to each expected stimuus for most efficient vision near threshold.


Response of potassium retentivity and survival of yeast to farultraviolet, near-ultraviolet and visible, and x-radiation. Potassium retentivity and survival of yeast were studied after exposure to various kinds and conditions of irradiation. The radiations used were: 2537 A ultraviolet, 3500 to 4900 A long-ultraviolet and short visible, and 250 kvp(1) x-rays. Both potassium retentivity and survival are decreased by these radiations. The dose-response of survival is about 16 times as sensitive as is potassium retentivity after 2537 A irradiation. Potassium retentivity is about twice as sensitive as survival after irradiation of 3500 to 4900 A. Survival after x-irradiation under aerobic conditions is five times as sensitive as potassium retentivity. Survival of cells irradiated with x-rays under anaerobic conditions was about half as sensitive as under aerobic conditions. The response of potassium retentivity to x-radiation at 25 degrees C. under anaerobic conditions is only slightly affected below 160 kr, at which dose the slope abruptly increases to that obtained under aerobic conditions; lowering the temperature to 0 degrees C. moves this point to about 300 kr. These differential effects are indicative of interaction of radiations with the yeast cell at sites that independently control survival and the retention of potassium.


Respiratory metabolism of normal and divisionless strains of Candida albicans. Respiration of a normal strain of Candida albicans was compared with that of a divisionless mutant which has a biochemical lesion such that metabolically generated hydrogen "spills over," during growth, for non-specific dye reduction. This waste is not at expense of growth, since both strains grow at essentially similar rates, nor at expense of respiration, since the mutant reduces oxygen more rapidly than the normal strain. Respiration in both strains is qualitatively similar, and seemingly unique among highly aerobic organisms in that it is not mediated by cytochrome oxidase. In resting cells of both strains, respiration is not only resistant to, but markedly stimulated by, high concentrations of cyanide, carbon monoxide, and azide. In contrast, growth of these yeasts is inhibited by low concentrations of cyanide and azide. Cytochrome oxidase could not be detected in cell-free preparations; reduced cytochrome c was not oxidized by such preparations. Cytochrome bands could not be observed in thick cell suspensions treated with reducing agents. However, incorporation of superoptimal levels of zinc and iron into the culture medium resulted in growth of cells possessing distinct cytochrome bands; respiration of these cells remained insensitive to cyanide, monoxide, and azide, and the bands were maintained in a reduced form on oxygenation. In the divisionless yeast, tetrazolium dyes compete with oxygen for reduction; this is not the case in the normal strain. The firmness with which hydrogen transfer is channeled in the latter for reduction of disulfide bonds (of importance in the division mechanism) and of oxygen, is contrasted with the lack of such control in the mutant.


The effect of x-radiation on the glutathione metabolism of intact erythrocytes in vitro. The x-irradiation of intact washed erythrocytes results in an inhibition of the glyoxalase activity of the cells chiefly as a result of a decrease in the reduced glutathione level. The percentage inhibition is markedly increased by an increase in the dilution of the cells in physiological saline suggesting that the effect of radiation is indirect, via the production in the aqueous medium of free radicals, H(2)O(2), etc. This is supported by the decrease in the inhibition produced by lowering the oxygen tension or by the addition of catalase. The inhibition of glyoxalase activity is also decreased by the addition of methylglyoxal, plasma, adenosine, inosine, glucose, and a number of other sugars to the erythrocyte suspension prior to radiation. Furthermore, some reactivation of the glyoxalase system results from the addition of plasma, glucose, adenosine, and inosine following radiation. These results are discussed in relation to the role of SH compounds, particularly glutathione, in the toxicity of ionizing radiations.


The relationship of hydrogen peroxide to the inhibition of the glyoxalase activity of intact erythrocytes by x-radiation. The x-irradiation of a dilute suspension of erythrocytes results in a decrease in the glyoxalase activity of the cells as a result of a fall in the reduced glutathione level. The present paper deals with the possible role of H(2)O(2) in this reaction. The addition of intact erythrocytes to physiological saline previously irradiated with 150,000 r or 225,000 r results in a fall in the glyoxalase activity of the cells. The inhibition is prevented by the preincubation of the irradiated saline with catalase and is reversed by the addition of plasma, glucose, adenosine, and inosine to the cell suspension. An inhibition of the glyoxalase activity is also produced by the addition of H(2)O(2) to the suspension of erythrocytes. The inhibitory effect of H(2)O(2) can be prevented and largely reversed by plasma, glucose, adenosine, and inosine. Methylglyoxal is also protective under these conditions. Hydrogen peroxide formed continuously and in low concentrations by enzyme systems appears to be more effective than added H(2)O(2) in inhibiting the glyoxalase system. The inhibition by H(2)O(2)-producing enzyme systems is minimized by the addition of catalase, plasma, glucose, methylglyoxal, and to a lesser extent, by adenosine and inosine, and is accentuated by the addition of sodium azide. The results are discussed in relation to the role of H(2)O(2) and catalase in the toxicity of ionizing radiations.


The distribution of inorganic phosphate in amphibian muscle. The Na(+), K(+), and inorganic phosphate levels of the plasma and sartorius muscle of the toad Bufo marinus were determined. Soaking in normal Ringer brought about the usual cation shifts, but did not alter the level of inorganic phosphate in the cell. Increases in the external phosphate level brought about an increase in the internal phosphate, but the apparent phosphate space of muscle is somewhat smaller than the apparent Cl(-) space. Phosphate spaces were compared with inulin spaces and were found to be significantly greater. Alteration of the H(+) concentration of the high phosphate Ringer did not alter the partition of phosphate across the cell membrane. These results have been found to be consistent with the theory of a three compartment system for muscle, wherein the tissue is assumed to consist of an extracellular phase, and two intracellular phases. The inorganic phosphate of the cell is assumed to be adsorbed onto the "ordered phase," and increments in organic phosphate found on raising the external level are assumed to take place in the "free intracellular phase."


Disposition of intraperitoneally injected calcium-45 in suckling rats. The time course of the concentration of radiocalcium was studied in the serum, skeleton, pelt, muscles, and pooled internal organs of 10-day-old rats. Within 10 hours of injection, the specific activity of the tissue groups exceeded the specific activity of the serum and remained above it during the period studied (120 hours). Chemical and autoradiographic analyses showed how rapidly most of the injected Ca(45) found its way into the skeleton. A model was constructed with the assumption that the skeleton constitutes an essentially irreversible reservoir for the tracer in a multicompartment system in which the blood is the central or feeding compartment. The rate of transfer of the tracer from the soft tissue compartments to the serum was calculated from the equation See PDF for Equation in which C = concentration in serum (expressed as a series of exponential terms) C' = concentration in a given soft tissue Substitution in the integrated form of this equation yielded equations which had the major properties of the empirical equations fitted to the experimental points. The relative order of transfer constants (k'(-1)) was: organs >/= pelt > muscle.


The secretion of inert gas into the swim-bladder of fish. The composition of the gas mixture secreted into the swim-bladders of several species of fish has been determined in the mass spectrometer. The secreted gas differed greatly from the gas mixture breathed by the fish in the relative proportions of the chemically inert gases, argon, neon, helium, and nitrogen. Relative to nitrogen the proportion of the very soluble argon was increased and the proportions of the much less soluble neon and helium decreased. The composition of the secreted gas approaches the composition of the gas mixture dissolved in the tissue fluid. A theory of inert gas secretion is proposed. It is suggested that oxygen gas is actively secreted and evolved in the form of minute bubbles, that inert gases diffuse into these bubbles, and that the bubbles are passed into the swim-bladder carrying with them inert gases. Coupled to a preferential reabsorption of oxygen from the swim-bladder this mechanism can achieve high tensions of inert gas in the swim-bladder. The accumulation of nearly pure nitrogen in the swim-bladder of goldfish (Carassius auratus) is accomplished by the secretion of an oxygen-rich gas mixture followed by the reabsorption of oxygen.


The refractory state of the generator and propagated potentials in a pacinian corpuscle. A propagated potential produced in the Pacinian corpuscle in response to mechanical stimuli leaves a refractory state of 7 to 10 msec. duration. The refractory state is presumably produced at the first intracorpuscular node of Ranvier. The recovery of receptor excitability for producing an all-or-none response to mechanical stimulation follows the same time course as that of the electrically excited axon. Upon progressive reduction of stimulus interval (mechanical), the propagated potential falls progressively to 75 per cent of its resting magnitude and becomes finally blocked within the corpuscle. A non-propagated all-or-none potential, presumably corresponding to activity of the first node, is then detected. The critical firing level for all-or-none potentials increases progressively during the relative refractory period of the all-or-none potential, as the stimulus interval is shortened. Thus generator potentials up to 85 per cent of a propagated potential can be produced in absence of all-or-none activity. Generator potentials show: gradual over-all increase in amplitude and rate of rise as a function of stimulus strength; constant latency; and spontaneous fluctuations in amplitude. A generator potential leaves a refractory state (presumably at the non-myelinated ending) so that the amplitude of a second generator response which falls on its refractory trail is directly related to the time elapsed after the first generator response and inversely to its amplitude. The generator potential develops independently of any refractory state left by a preceding all-or-none potential.


Generator processes of repetitive activity in a pacinian corpuscle. Response patterns resulting from repetitive mechanical stimulation of the corpuscle depend on (1) the time course of recovery of the generator potential, on (2) the recovery of critical firing height, and on (3) the stimulus strength/generator potential function. By either augmenting stimulus frequency at constant strength, or by reducing strength at constant frequency, a sequence of propagated potentials is turned into a pattern of alternating regenerative and generator responses. In such a pattern an extra impulse can be set up whenever an extra stimulus produces a generator potential of enough amplitude to reach the firing height of the corresponding period. The new requirements of firing height introduced by the refractory trail of the extra impulse determine resetting of periodicity and appearance of a "compensatory pause." The decay time of the single generator potential is independent of stimulus duration. This is interpreted as a factor determining receptor adaptation. Upon repetitive stimulation at intervals above (1/2) decay time of the single generator potential, a compound generator potential is built up which shows no spontaneous decline. However, in spite of being considerably greater than the firing height for single impulses, the constant level of depolarization of the compound generator potential is unable to produce propagated potentials. A hypothesis is brought forward which considers the generator potential to arise from membrane units with fluctuating excitability scattered over the non-myelinated nerve ending.


Psychotherapy with adolescent girls in court clinic.


Facilitation by previous activity in a pacinian corpuscle. A period of supernormal excitability is left by a propagated impulse in a Pacinian corpuscle. The increase in excitability is found 6 to 10 msec. after an impulse occurs in the corpuscle. Supernormality is produced by either mechanically elicited dromic impulses, or by electrically excited antidromic impulses. Generator potentials do not cause supernormality. Local potentials discharged spontaneously by the corpuscle, and which fall on the supernormal trail left by an antidromic impulse, become enhanced in amplitude, an eventually are turned into propagated dromic potentials. The supernormal period is interpreted as caused by a negative after-potential left at the first intracorpuscular node of Ranvier which outlasts both the recovery time of the firing level and that of the generator potential during the corpuscle's relative refractory period.


Effect of adrenalectomy on anxiety motivated behavior.


Effect of adrenalectomy on emotional elimination.


A formula for selecting toys for nondirective play therapy.


Hunger motivation in the rat following local application of cobalt-60.


An analysis of manifest content of the earliest memories of children.


Latent changes in the food preferences of irradiated monkeys.


Rosenzweig picture-frustration study results with minority group juvenile delinquents.


Parents' attitudes and adjustment of children.


Marginal social values of rural school children.


A study of developmental changes in conceptual and perceptual associative clustering.


Mothers' and fathers' differences in parental acceptance of children for controlled comparisons based on parental and family characteristics.


Assignment of gender to body regions.

Assignment of gender to body regions.


The defense mechanisms that students report in their own behavior.


The effects of age, sex, and race upon the acetic acid fractions of collagen (human biopsy-connective tissue).


The effect of aging on mucopolysaccharide composition of human costal cartilage as measured by hexosamine and uronic acid content.


Histologic and histochemical studies on the periosteum of male and female rats at different ages.


Age differences in cholinesterase activity of serum and liver.


The lactic dehydrogenase, malic dehydrogenase, and phosphoglucoisomerase activities of coronary artery tissue in individuals of various ages.


Teeth, bones, and aging of Syrian hamsters.


Deficiencies in the lipoprotein lipase system in atherosclerosis.


Osteoporosis in the aged: radiographic survey with clinical and biochemical correlations.


A new tranquilizing soporific for insomnia; the value and safety of methapyrilene and scopolamine in combination.


Method-of-approach factors in the testing of middle-aged subjects.


A comparative study of elderly mental hospital patients and residents of homes for the aged.


The projection of personal symptom into stereotype about aging.


Index to current periodical literature.

Index to current periodical literature.


Age differences in work attitudes.

Age differences in work attitudes.


Applications of histochemistry to electron microscopy.


Some histochemical observations on normal and diseased human skeletal muscle.


Histochemical methods for calcium.

Histochemical methods for calcium.


Standard chemical fixations as a basis for quantitative investigations of substances other than deoxyribonucleic acid.


Histological localization of glycogen in the urinary tract and lung.


The localization of adenosine triphosphatase in liver: in situ staining and cell fractionation studies.


A modification of the Koelle technique for use with oximes.


Observations on the use of sulfuric acid in ether for the sulfation of hydroxyl groups in tissue sections.


Monotetrazoliums and metal chelation for better localization of dehydrogenases.


A cytological basis for the biochemical study of bronchial epithelium.


Cytochemistry of the L.E. cell phenomenon of systemic lupus erythematosus.


Improvement in the histochemical localization of succlnic dehydrogenase by use of nitroneotetrazolium chloride.


The Nile blue reaction of peptic gland zymogen granules: the effect of methylation and alkali demethylation.


Histochemical demonstration of beta-D-galactosidase in the rat.


Histochemical demonstration of an acetylcholinesterase in the ova of Schistosoma mansoni.


A new carbowax method for routinely performing lipid, hematoxylin and eosin and elastic staining techniques on adjacent freeze-dried or formalin-fixed sections.


Crystalline calcium sulphate (gypsum) in scleral plaques of a human eye.


Quantitative appreciation by comparative autoradiography of the synthesis and maintenance of some organic constituents of the epiphyseal plate of growing rats, in relation with magnesium deficiency.


Obiter dicta bibliographica.

Obiter dicta bibliographica.


Ancient Peruvian medicine.

Ancient Peruvian medicine.


The genesis and impact of the medical lobby: 1898-1906.


Cutting for the stone.

Cutting for the stone.


The discovery of insulin.

The discovery of insulin.


The isolation in tissue culture, chick embryo and suckling mice of filtrable agents from healthy dairy cattle.


Tissue culture studies of cellular hypersensitivity in rheumatic fever. I. The response of human white blood cells to Streptococci and to crude filtrates of streptococcal cultures.


Tissue culture studies of cellular hypersensitivity in rheumatic fever. II. The response of fibroblasts from human skin and heart to disintegrated Streptococci and to crude filtrates of streptococcal cultures.


Tissue culture studies of cellular hypersensitivity in rheumatic fever. III. A reexamination of tuberculin hypersensitivity in tissue culture by a study of the response to old tuberculin of human white blood cells and fibroblasts from human and guinea pig skin.


Factors influencing host-virus interactions. III. Further studies on the alteration of Coxsackie virus infection in adult mice by environmental temperature.


Adsorption, multiplication, and cytopathogenicity of enteroviruses (poliomyelitis, Coxsackie, and ECHO groups) in susceptible and resistant monkey kidney cells.


Antigenic analyses of influenza viruses by complement fixation. I. The production of antibodies to the soluble antigen in guinea pigs.


The effects of antibiotics on enterobacterial lipopolysaccharides (endotoxins), hemagglutination and hemolysis.


Influences upon the agglutinability of rabbit erythrocytes in the presence of iso-antibody: genetic factors.


Anaphylaxis in Hemophilus pertussis-treated mice. I. Passive anaphylaxis with heterologous rabbit antibody.


Inhibition of Rho(D) antibody by eluates from Rho(D) erythrocytes treated with mumps virus or the periodate ion.


A passive hemagglutination reaction for psittacosis.


The reversible and irreversible toxic effects of anti-Hela cell rabbit serum upon human cell lines in tissue culture.


A study of the effect of antiserum on poliovirus infection induced by the intraspinal inoculation of rhesus monkeys.


Epidemiologic implications of the distribution by age of antibody response to experimental influenza virus vaccines.


Staining of complement and modification of fluorescent antibody procedures.


The immune response of the guinea pig to the antigens of Pasteurella pestis.


In vitro and in vivo studies on a tissue culture cell line derived from normal monkey heart.


Experiences with chlorpromazine in the treatment of institutionalised psychotics.


Sickle cell anaemia in Assam.

Sickle cell anaemia in Assam.


Hb.S-thalassaemia disease in India.

Hb.S-thalassaemia disease in India.


Infections and gangrene of the foot complicated by diabetes.


Unilateral exophthalmos.

Unilateral exophthalmos.


Congenital anhidrotic syndrome.

Congenital anhidrotic syndrome.


ABNORMAL haemoglobins.

ABNORMAL haemoglobins.


Peptic ulcer in poorer communities of west Bengal: analysis of 100 proved cases.


Mecamylamine hydrochloride in the treatment of hypertension.


Complications of peptic ulcer; their management.


Rupture of the pregnant uterus.

Rupture of the pregnant uterus.


Bilateral optic neuritis and encephalitis complicating typhoid fever.


Amaurotic familiar idiocy.

Amaurotic familiar idiocy.


Clinical aspects and diagnosis of yaws (framboesia tropica).


Pneumoconiosis in the nonindustrial population of Rajasthan.


Bronchopulmonary moniliasis.

Bronchopulmonary moniliasis.


Coma; causes and diagnosis.

Coma; causes and diagnosis.


Laurence-Moon-Biedl syndrome.

Laurence-Moon-Biedl syndrome.


PAY, STATUS and remuneration of medical men.


The hospital of the future.

The hospital of the future.


Infective hepatitis in Lucknow: a survey of 10 year hospital records.


A simplified and rapid papain method in RH typing, antibody detection and compatibility testing.


Common gynaecological conditions in children.


Smallpox in Uttar Pradesh (1877-1954).

Smallpox in Uttar Pradesh (1877-1954).


Antepartum and intrapartum eclampsia.

Antepartum and intrapartum eclampsia.


Lingular disease simulating the right middle lobe syndrome; report of a case.


Anatomical studies of the main pancreatic duct.


The physician and re habilitation of his hemiplegic patients.


The treatment of common respiratory infections.


Medical Evansville a century ago.

Medical Evansville a century ago.


Comparative susceptibility of various species of mice native to Washington to inoculation with virulent strains of Pasteurella pestis.


Bacterial infections in wild rodents of eastern and central Washington.


Total gastrectomy for carcinoma.

Total gastrectomy for carcinoma.


Incomplete surgical removal of the appendix; its complications.


On typing of Staphylococcus aureus: the relationship between typing according to phage patterns, serology, and antibiograms.


Atresia of the alimentary tract in the newborn.


Lysozyme treatment of tuberculous mice.

Lysozyme treatment of tuberculous mice.


Gastroileostomy with realignment and recovery; report of a case.


The role of antibody in immune hemolysis.


Coronary endarterectomy.

Coronary endarterectomy.


Transposition of the cord in surgical treatment of varicocele.


Acquired diverticulum of the male urethra with calculi; report of a case.


Isolation and reversion of L forms of beta-hemolytic streptococci.


The effect of x-irradiation on preformed antibody and its role in the protection of x-irradiated mice.


Lipoma of the corpus callosum.

Lipoma of the corpus callosum.


Surgical treatment of spontaneous intracerebral hemorrhage.


Studies on immunity to Asiatic cholera. X. Heat stable cell wall and intracellular antigens of Vibrio cholerae independent of agglutinogens and demonstrable by passive hemagglutination.


Effect of x-ray radiation on Trypanosoma equiperdum in vivo and in vitro.


The relation between hemolysin concentration and hemolytic rate as measured with chromium 51 labeled cells.


Use of Lugol's solution and starch in testing for pregnancy: experimental use.


Surgical treatment of uterine and vaginal prolapse; a technic without recourse to nonexistent facia.


Torsion of ovarian pedicle in a virgin; report of a case.


A study of a modified Tinsdale's medium for the primary isolation of Corynebacterium diphtheriae.


The double pin method in the treatment of fractures of the tibia and fibula; a nineteen year analysis 1937-1956.


Dowel intervertebral body fusion as used in lumbar disc therapy.


Diagnosis and management of malignant tumors of the nose and accessory sinuses.


Transmeatal and endaural typanoplasty; observations from experience of 152 operations.


Extrarectal metastases from malignant disease of the mammary area and part of the abdomen simulating primary rectal carcinoma.


The lymph nodes in the mediastinum.

The lymph nodes in the mediastinum.


The persistence of allergic eczematous sensitivity and the cross-sensitivity pattern to paraphenylenediamine.


Respiration of human skin; normal values, pathological changes and effect of certain agents on oxygen uptake.


The response of the human epidermis to the application of carcinogenic hydrocarbons.


Proteolytic activity in dermatoses: studies of blood of patients with pruritus.


Ringworm epizootics in laboratory mice and rats: experimental and accidental transmission of infection.


The germination of the fuseaux of Microsporum fulvum.


Isocitric dehydrogenase activity of human epidermis.


Induction of allergic contact dermatitis in patients with the lymphoma-leukemia complex.


Inhibitors of lipemia clearing in tissues.


Sulfhydryl oxidase activity in skin homogenates.


Pathologic patterns of the sehaceous gland.


The quantitative nutritional requirements of the genus Microsporum.


The effect of amino acids on the growth and sporulation of Trichophyton rubrum; possible application to diagnosis and therapy.


Influence of varying physical factors on patch test responses.


The effect of pH and the presence of other elements in solution on the absorption of boron.


Blood boron levels in human infants.

Blood boron levels in human infants.


Topical application of chlorpromazine: its effect on the erythema response to ultraviolet light.


Ring closure and fungistatic activity.

Ring closure and fungistatic activity.


Gifts and short term trusts.

Gifts and short term trusts.


One hundred colon cancers.

One hundred colon cancers.


Surgical significance of small bowel tumors.


Early diagnosis of cancer of the head and neck.


A surgeon's stand on thyroid disease.

A surgeon's stand on thyroid disease.


Sero-mucoid otitis media.

Sero-mucoid otitis media.


The management of diabetes during surgery.


Foot complications in diabetes.

Foot complications in diabetes.


Insulin therapy of diabetic children.

Insulin therapy of diabetic children.


Diseases of the skin in diabetes.

Diseases of the skin in diabetes.


Disseminated mucormycosis in a child with diabetes mellitus; a case report.


The neurologic complications of diabetes mellitus.


Open heart surgery under hypothermia: report on ten cases.


Vice and the law: some aspects of the Wolfenden report.


Some reflections on the epidemics of the Middle Ages.


A rough estimate of two main racial components in the Republic of Ireland, based on an analysis of ABO blood group frequencies.


Paediatric problems in family practice.

Paediatric problems in family practice.


Evolution in the surgery of pulmonary tuberculosis.


A case of pyogenic empyema necessitatis.


The need for a centre for treatment of paraplegia in Ireland.


Maternal deaths; an outline of a study in Kansas as it relates to improvement in mortality rates.


Diabetes mellitus: screening blood sugar tests in Kansas, 1956 and 1957.


Diaphragmatic hernia; traumatic, with herniation of tumor of liver.


Gastric ulcer and malignancy.

Gastric ulcer and malignancy.


Herpes simplex; a review of etiology, manifestations, transmission and epidemiology.


The Medical Center; a resume of progress and a look at the future.


Exchange transfusions; experiences at University of Kansas Medical Center over a two-year period.


Polycythemia vera; study of coagulation abnormalities, both thrombotic and hemorrhagic.


Arteriovenous fistula; report of case developing after operation for ruptured intervertebral disc and successfully repaired by homograft.


Deafness; examination techniques for evaluating malingering and psychogenic disabilities.


Primary carcinoma of the vagina; results of treatment by radiation.


Asian influenza vaccine; how effective was it in prevention of acute respiratory infection at the University of Kansas Medical Center.


Caustic esophageal stricture; a review of the literature and a suggested plan of treatment.


Complications of hypoglycemia.

Complications of hypoglycemia.


Modern concepts in the management of hepatic failure.


Conservative management of post-operative surgical complications in pulmonary tuberculosis.


Hypertension of renal origin.

Hypertension of renal origin.


COMPLETE genital prolapse.

COMPLETE genital prolapse.


Clinical research; a career.

Clinical research; a career.


Studies on the nature of the plasma erythropoietic factor (S).


Bile and vitamin B12 absorption.

Bile and vitamin B12 absorption.


Iron absorption. I. Factors influencing absorption.


Iron absorption. II. The absorption of radioiron administered with a standard meal in man.


Lowered glucose utilization, phosphate uptake, and reduced glutathione content of erythrocytes following bilateral nephrectomy.


Zone electrophoretic studies on the distribution of the L.E. factor in the serum proteins and urinary proteins from patients with systemic lupus erythematosus.


The effect of 5-hydroxytryptamine (serotonin) on the respiration on nonasthmatic and asthmatic subjects. I.


The elastic properties of the lungs in the aged.


Cardiac output and related measurements and pressure values in the right heart and associated vessels, together with an analysis of the hemo-dynamic response to the inhalation of high oxygen mixtures in healthy subjects.


Survival time of the erythrocyte in myxedema and hyperthyroidism.


Poliomyelitis and aseptic meningitis; a two-year field and laboratory study in Connecticut.


Arteriovenous shunting in palmar erythema; the effect upon blood ammonia determinations.


Flocculation tests for tularemia.

Flocculation tests for tularemia.


Sites of origin and removal of blood ammonia formed during glycine infusion: effect of L-arginine.


A simple fluid medium for diphasic fungi.


Microestimation of serum cholesterol and esters on finger-tip blood.


An improved technique for assay of C14O2 in expired air using the liquid scintillation counter.


Objective interpretation of precipitate patterns in agar diffusion precipitin plates.


The construction of a sensitive accelerometer.


The effect of hydrocortisone and cortisone on fixation of S35 in the stomach.


The importance of amino acids as dialyzable components of rat serum which promote sulfate uptake by cartilage from hypophysectomized rats in vitro.


Mechanisms regulating the retention of sodium in the feces by cation-exchange resin; release of base from the resin by bacterial fermentation in the terminal ileum.


Clinical and laboratory observations on two trifluoromethyl phenothiazine derivatives.


The function and capacity of the adrenal cortex immediately before radiation sickness death.


Constancy of urinary creatinine excretion.


Guanidinium compounds in blood and urine of patients suffering from muscle disorders.


Plasma uric acid levels, uric acid excretion, and response to probenecid in toxemia of pregnancy.


Exploration of the phagocytic function of the reticuloendothelial system with heat denatured human serum albumin labeled with I131 and application to the measurement of liver blood flow, in normal man and in some pathologic conditions.


Spherocytic hemolytic anemia associated with acute pneumococcal infection in rabbits.


Cardiac output measured by the injection method with the use of radioactive material and continuous recording. II. Comparison with the Fick method.


The disappearance rate of glutamic oxalacetic transaminase from the circulation and its distribution in the body's fluid compartments and secretions.


Immunocytochemical study of plasma cells in multiple myeloma.


Histoplasmosis as a problem in tuberculosis sanatoriums throughout the United States.


The concealment of heavy bacterial contamination in 25 percent human serum albumin; its mechanism and clinical significance.


Insulin binding in vitro by leukocytes from normal and diabetic subjects.


Glutathione concentration in the erythrocytes of normal infants and infants suffering from erythroblastosis fetalis.


Protective effect of components of normal blood against the lethal action of endotoxin.


Prothrombin measurement by two-stage technique with hemolyzed whole blood thromboplastin.


Use of a nonionic detergent in paper electrophoresis of serum proteins.


Simplified colorimetric method for true blood glucose.


Separation of beta lipoprotein from normal and hyperlipemic human sera.


Plasma cholinesterase and other liver function tests in hepatic amebiasis.


The base binding property of the serum proteins with respect to calcium.


The catheptic contribution to blood acid protease.


Alimentary lipemia and coronary artery disease in two racial groups.


Further studies on the erythrocyte concentration of potassium in conditions of hyponatremia and hypernatremia.


Cholesterol ester synthesis and hydrolysis of splenic tissue in lymphoma.


The effect of CO2 inhalation on the conjunctival vessels, blood pH, and pCO2 in young diabetic subjects.


Effects of intravenous human plasmin on the blood clotting mechanism of the dog.


Antihemophilic factor deficiency in the female.


Congenital coagulation deficiency of Stuart factor activity.


Comparative erythropoietic incorporation of ferric and ferrous preparations of iron-59 by the monkey, Macaca mulatta.


The utilization of saccharated Fe59 oxide in red cell formation.


A study on orange-pigmented non-photochromogenic mycobacteria.


Effect of sera from patients with anoxia on the proliferative activity of human erythropoietic tissue in vitro.


The use of bromsulphalein (B.S.P.) as an indicator for the determination of cardiac output by the dye dilution technique.


The photometric microdetermination of blood glucose with glucose oxidase.


An instrument and method for automatic, rapid, accurate, and sensitive titration of chloride in biologic samples.


A simplified semiautomatic bio-assay apparatus.


Diffusion of progesterone and desoxycorticosterone into nitrocellulose (lusteroid): a potential source of error in ultracentrifugation.


Comparison of the extraction of potassium and sodium from liver tissue by acid and water.


The fluorimetric measurement of plasma epinephrine and norepinephrine concentrations in man, monkey, and dog.


A note on the serum iron determination described by Peters, Giovanniello, Apt, and Ross.


The treatment of diabetic acidosis.

The treatment of diabetic acidosis.


Studies on the serologic identification of adenovirus. I. Comparison of the hemagglutination, conglutinating complement adsorption, and complement fixation tests.


Trauma and thrombophlebitis.

Trauma and thrombophlebitis.


Pilonidal disease.

Pilonidal disease.


The clinical significance of hoarseness and related voice disorders.


Ovarian tumors.

Ovarian tumors.


Colic in infancy.

Colic in infancy.


An anesthesiologist's approach to prevention of operating room deaths.


Meningococcic meningitis and meningococcemia with probable Waterhouse-Friderichsen syndrome.


Will E. Donahoe.

Will E. Donahoe.


Surgery in heart disease.

Surgery in heart disease.


Spontaneous subarachnoid hemorrhage.

Spontaneous subarachnoid hemorrhage.


Acute nonspecific pericarditis.

Acute nonspecific pericarditis.


Rectal bleeding in infants and children.


Office gynecology.

Office gynecology.


Intermittent obstructive jaundice in Hodgkin's disease: report of a case.


Immediate planning for definitive treatment of severely injured individuals with multiple fractures.


Health of the American Indians.

Health of the American Indians.


The medicinal treatment of asthma.

The medicinal treatment of asthma.


Abductor paralysis in theory and practice since Semon.


Some clinicopathological observations on scleroma.


Electrical nystagmography and its use in the clinical investigation of vestibular function.


Myringoplasty; the surgical repair of tympanic membrane perforations.


On tympanoplasty.

On tympanoplasty.


Malingering as a fine art.

Malingering as a fine art.


Leukoplakia of the larynx complicated by carcinoma.


The superior Vidau flap.

The superior Vidau flap.


The mobilization operation in the treatment of otosclerosis.


The fenestration operation: a review based on an analysis of 139 operations.


Circulation of labyrinthine fluids.

Circulation of labyrinthine fluids.


Neurogenic tumours of the head and neck; report of four cases.


Some problems of tympanoplasty.

Some problems of tympanoplasty.


Embryonic sarcoma (rhabdomyosarcoma) of the nasopharynx presenting with facial palsy.


A case of familial haemorrhagic telangiectasia associated with pulmonary arteriovenous fistula.


Extracranial neurilemmoma of the vagus.

Extracranial neurilemmoma of the vagus.


The physician and privileged communications.


Acute pancreatitis.

Acute pancreatitis.


The value of delayed urograms.

The value of delayed urograms.


The technique of proctoscopy.

The technique of proctoscopy.


Emergency gastrectomy for acute gastroduodenal perforation.


Pinpointing public health needs in Louisiana; an interim report.


Optic and retrobulbar neuritis.

Optic and retrobulbar neuritis.


Facial injuries.

Facial injuries.


Preventive cardiology.

Preventive cardiology.


Seasonal variations in electrocardiography.


Vassopressor drugs in shock following myocardial infarction.


Angina pectoris or cardiac neurosis.

Angina pectoris or cardiac neurosis.


The roentgenological diagnosis of placenta praevia.


Why physicians should not be under social security.


Retinal separation in young adults.

Retinal separation in young adults.


The etiology of mental retardation. I.

The etiology of mental retardation. I.


Drug reactions.

Drug reactions.


Wound closure in cataract surgery.

Wound closure in cataract surgery.


Benign stricture of esophagus simulating carcinoma.


The problem of the mentally retarded child in Maine.


Chlorothiazide; a nonmercurial diuretic agent.


Chronic ulcerative colitis; a case report.


Maine doctors of long ago.

Maine doctors of long ago.


The etiology of mental retardation. II.

The etiology of mental retardation. II.


Hepatic coma induced by high protein therapy and by diarrhea; two case reports.


Radiotherapy of plantar warts.

Radiotherapy of plantar warts.


Practical error in urinary bacterial colony counts.


Five year in-patient study of fractured hips.


Subphrenic abscess with thoracic complications; case report.


Treatment of Osgood-Schlatter's disease (tibial tubercle epiphysitis); case reports.


Palliative treatment of benign prostatic hypertrophy; value of glycine-alanine-glutamic acid combination.


The importance of good nutrition during pregnancy.


[Treatment of acute afibrinemia].

[Treatment of acute afibrinemia].


[Observations concerning certain pancreatic affections].


Thrombosis and thrombophlebitis.

Thrombosis and thrombophlebitis.


Gastric diverticulum.

Gastric diverticulum.


Anesthetic Study Commission report.

Anesthetic Study Commission report.


Treatment of myocardial infarction with anticoagulants.


Pituitary apoplexy.

Pituitary apoplexy.


Management of acute cholecystitis.

Management of acute cholecystitis.


Diet and congestive heart failure.

Diet and congestive heart failure.


Management of the patient with rheumatoid arthritis.


A combined right thoraco-abdominal approach to high esophageal lesions.


Anesthesia for the cardiac patient.

Anesthesia for the cardiac patient.


Non-TB pulmonary disease simulating pulmonary TB.


Heart failure and tuberculosis.

Heart failure and tuberculosis.


Dermatologic manifestations of internal disease.


Diverticular disease of the colon; a clinical report.


The possibility of surgical stress as an etiology of secondary porphyrinuria.


Rupture of arteriosclerotic aneurysm of splenic artery; report of case.


The role of the physician in adoptions.

The role of the physician in adoptions.


Heeding the warning signs of chickenpox.


Medical education in India; a challenge.


An inquiry into the value of rank grades in the medical course.


The role of research in the medical curriculum.


The Rochester student fellowship program.


The psychiatrist in an ambulatory clerkship for comprehensive medical care in a new curriculum.


Personality inventory profiles during and after real life stress.


Higher education in the United States.

Higher education in the United States.


The education of the physician in the United States: the current scene; medical education in the United States: a background resume.


Evaluation of the applicant for medical education.


Objectives and organization of a medical school.


A comprehensive evaluation of the development of the medical curriculum.


Current trends in medical education: a research approach.


Brucellosis: a public health problem in Lebanon.


Serologic diagnosis of hydatid disease by indirect hemagglutination.


Certain aspects of the management of renal failure.


Some aspects of the physiology and pharmacology of experimental auricular flutter and fibrillation.


Primary care of the injured hand.

Primary care of the injured hand.


Pheochromocytoma: diagnosis and treatment illustrated by a case report.


Cardiopulmonary schistosomiasis: pathology and pathogenesis.


Cardiopulmonary studies in schistosomiasis. II. The clinical aspects of bilharzial corpulmonale.


Cardiopulmonary studies in schistosomiasis. III. Pulmonary function tests, hemodynamic and pharmacodynamic studies in bilharzial cor pulmonale.


Studies on mercurial diuretics.

Studies on mercurial diuretics.


Treatment of common soft tissue injuries of the knee joint.


A survey of Schick-testing in some of the Bekaa villages.


The mechanical heart; its mechanism and clinical application.


Transurethral prostatic resection in the aged.


Diagnostic aids in rheumatoid arthritis.


THE ROLE of insurance in meeting the costs of medical care. I. Health insurance fundamentals.


Treatment of psychiatric disorders in mental defectives with perphenazine.


Malformation of the anus and rectum.

Malformation of the anus and rectum.


Spontaneous healing of choledochoduodenal fistulas.


The heritage of the autopsy.

The heritage of the autopsy.


Relatives of phenylketonuric patients.

Relatives of phenylketonuric patients.


Dementia infantilis Heller; diagnostic problems with a case report.


Tranquillizers in mental deficiency: chlorpromazine.


The serum cholesterol level in children with mongolism and other mentally retarded children.


Similarity of blood antigens in mother and mongol child.


An attempt to determine reaction to adrenaline in phenylketonuria.


Congenital ichthyosis, spastic diplegia and mental deficiency.


Report of the Royal Commission on the law relating to mental illness and mental deficiency (1954-1957).


The thirty-second Maudsley Lecture: sensory experience and brain structure.


Alcohol, alcoholism and conditioning: a review of the literature and some theoretical considerations.


A clinical investigation of chronic schizophrenia.


Neurosis and experimental psychology.

Neurosis and experimental psychology.


A census of psychiatric cases in two contrasting communities.


Preventive psychiatry; is there such a thing.


The Pavlovian theory of hypnosis: an evaluation.


Chemical and pathological findings in a case of late infantile amaurotic family idiocy of the Batten type.


The problem of unemployment among epileptics.


A survey of 44 children admitted to the Fountain Group Hospital under the mental deficiency act and subsequently accepted as educable.


Blink rate and muscle tension.

Blink rate and muscle tension.


Psychiatric syndromes associated with cerebrovascular disorders in the African.


Differential effects of lysergic acid and sodium amytal on immediate memory and expressive movement.


D-amphetamine and amytal. II. Effects on certainty and adequacy of certainty in recall and recognition.


D-amphetamine and amytal. I. Effects on memory and expressive movement.


The ineducable child.

The ineducable child.


Mental abnormality and military delinquency.


The effects of notensil in chronic mental illness.


Effects of electrical stimulation of the brain of the concentration of adrenaline-like substances in human plasma.


Investigation of amino acids in a periodic catatonic patient.


Combined chlorpromazine and reserpine in the treatment of chronic psychotics.


A comparison between the results of unmodified and modified electro plexy (E.C.T.).


Unilateral electro-convulsive therapy.

Unilateral electro-convulsive therapy.


A reasonable attitude toward the medical use of diagnostic radiation.


The role of the physician in the care of the mentally retarded.


Preventive medicine and industry.

Preventive medicine and industry.


The effect of antimetabolites on embryonic development.


Early diagnosis of disease at the place of work.


Today's challenge in public health.

Today's challenge in public health.


Can we rely on modern medicines.

Can we rely on modern medicines.


The Johnson operation for acquired and congenital coronary insufficiency.


Chronic adrenal insufficiency; a diagnostíc dílemma.


Small plant medical care.

Small plant medical care.


Outposts of medical research.

Outposts of medical research.


The self-destructive factor in the medical patient.


A cataract of consequences.

A cataract of consequences.


The nature of apraxia.

The nature of apraxia.


Patent ductus arteriosus with pulmonary hypertension.


Some aspects of amino acid and protein metabolism of the nervous system.


Visceral brain, its component parts and their connections.


Effects of septal and amygdaloid lesions on emotional behavior and conditioned avoidance responses in the rat.


The severely defective individual.

The severely defective individual.


Experimental pancreatitis; a critical review.


On the participation of adaptive hormones in disease susceptibility; illustrated by the acquisition of resistance to an experimental nervous desease during adaptation to cold.


The gastroesophageal vestibule on roentgen examination: differentiation from the phrenic ampulla and minimal hiatal herniation.


The relative merits of encephalography and ventriculography for the investigation of intracranial tumours.


Malignant hemangioendothelioma: report of two cases and review of the literature.


Ischaemic and post-ischaemic numbness and paraesthesiae.


Performance testing and calibration of the ballistocardiographic apparatus.


Pantopaque fourth ventriculography via the lumbar route (REG).


The surgical prognostic significance of the electroencephalographic prediction of Ammon's horn sclerosis in epileptics.


Early recognition and management of psychiatric disorders in general practice.


A report of two cases of the juvenile form of amaurotic familial idiocy (cerebromacular degeneration).


Spinal angioma with symptoms in pregnancy.


Pulsating exophthalmos in von Recklinghausen's disease.


Posterior mediastinal parathyroid adenoma.


Optic atrophy and nerve deafness in diabetes mellitus.


Sodium amytal and extraversion.

Sodium amytal and extraversion.


A controlled trial of methyl phenidate (ritalin) in the treatment of depressive states.


Epinephrine metabolites and pigmentation in the central nervous system in a case of phenylpyruvic oligophrenia.


Crossed reflex effects evoked by activity in myelinated afferent fibers of muscle.


Reticular formation influences on neurons of spinal reflex pathway.


Current-voltage relations of single nodes of Ranvier as examined by voltage-clamp technique.


Electrical identification of certain nuclei and fiber tracts in brain of cat.


Changes associated with post-tetanic potentiation of a monosynaptic reflex.


Effects of spreading depression on direct cortical response studied with an island technique.


Coordinated eye and body movements evoked by brainstem stimulation in decerebrated cats.


Electrophysiology of olfactory bulb.

Electrophysiology of olfactory bulb.


Mechanism of scalp and skull injuries, concussion, contusion and laceration.


Physiological basis of concussion.

Physiological basis of concussion.


Alterations in cell structure of the brain associated with experimental concussion.


Studies of barrier and carto-car impacts.


Research and design to reduce likelihood of accident.


Instrument panel impacts and snubbing deceleration tests.


Hypothermia in the treatment of craniocerebral traumatism.


Side-to-side anastomosis between the external and internal carotid arteries in the treatment of carotid insufficiency.


The one-stage method of cranioplasty with acrylic plastic with a follow-up study.


Intracranial internal carotid artery aneurysms; results of treatment by cervical carotid artery ligation.


Lyophilized human dura mater as a dural substitute.


Hypothermia in the treatment of cerebral tumors.


Clinical use of freeze-dried human dura mater.


A new isotope method for detecting continued or recurrent bleeding after subarachnoid hemorrhage.


Intracranial eradication of middle cerebral aneurysms.


Gilbert Horrax; 1887-1957.

Gilbert Horrax; 1887-1957.


Philip Charles Jeans.

Philip Charles Jeans.


Nutritional studies with glycine, aminoethanol and related compounds in the chick.


The absorption of radio-lysine by the chick as affected by penicillin administration.


The effect of the Ingestion of ascorbic acid and dehydroascorbic acid upon the blood levels of these two components in human subjects.


Nutritional studies with the hyperthyroid rat.


Exudative diathesis in chicks.

Exudative diathesis in chicks.


Dietary mineral interrelations as a cause of soft tissue calcification in guinea pigs.


The acceleration of vitamin E deficiency in the chick by torula yeast.


Nitrogen balances of women maintained on various levels of methionine and cystine.


The effect of ethionine feeding on liver and kidney coenzyme A content in the rat.


The absorption by immature and adult rats of amino acids from raw and autoclaved fresh pork.


The nutritive value of bread flour proteins as affected by practical supplementation with lactalbumin, nonfat dry milk solids, soybean proteins, wheat gluten and lysine.


Studies in prolonged pregnancy. II. Cord haemoglobin levels at delivery.


Studies in prolonged pregnancy. III. The quantity of foetal type haemoglobin in relation to foetal age and weight.


Studies in prolonged pregnancy. IV. Clinical assessment.


Hospital in-patient enquiry; study of 10,145 discharges or deaths from maternity departments during 1954.


Perineal anterior exenteration.

Perineal anterior exenteration.


Tuberculosis of the female genital tract in South India; an intra-continental comparison.


The respiratory minute volume in the newborn infant.


Three cases of malignant change in endometriosis, including two cases arising in the recto-vaginal septum.


Acute tubular nephrosis complicating septic abortion and peritonitis; a case illustrating further difficulties in management.


Prolapse of the fallopian tube following hysterectomy.


The estimation of foetal maturity.

The estimation of foetal maturity.


Adenocarcinoma of the endometrium with malignant stromatosis.


Acute hydramnios treated by abdominal paracentesis; case report.


A gynaecological study of 800 diabetics.


On the safety of the pitocin drip.

On the safety of the pitocin drip.


Gastric function in pregnancy.

Gastric function in pregnancy.


Ovarian cyst with torsion and rupture in an infant.


Vaginal delivery after caesarean section; rupture of the lower segment scar.


Malignant changes in procidentia; the incidence during the years 1949-54 at Addenbrooke's Hospital, Cambridge.


Aplastic anaemia during pregnancy; a case report.


Endometrial abnormalities including carcinoma associated with ovarian Brenner tumours.


Morpholinoethylnorpethidine hydrochloride in obstetrics.


The management of intra-uterine death of the foetus.


Tension pain in gynaecological practice.


Obstruction of labour due to incarceration of the non-gravid corpus in a case of uterus didelphys.


Masculinizing ovoblastoma of the ovary; report of a case.


Sudden death due to amniotic fluid embolism.


Uterus didelphys with double pregnancy.

Uterus didelphys with double pregnancy.


Early maternity hospitals in Edinburgh; 1756-1879.


Clifford White.

Clifford White.


Ethylene glycol antifreeze poisoning.

Ethylene glycol antifreeze poisoning.


Stop rheumatic fever; laboratory and clinical diagnosis.


Diverticula of the pericardium.

Diverticula of the pericardium.


The management of diffuse fecal peritonitis.


The effects of digoxin on cardiac output and hemodynamics in experimental supravalvular mitral stenosis.


The control of a post-natal epidemic of breast abscesses in a general hospital.


Stop rheumatic fever.

Stop rheumatic fever.


Splenectomy for congenital hemolytic anemia.


Difficulties in differenti: between chorio-adenoma destruens and choriocarcinoma.


Pathogenesis of herpes simplex virus.

Pathogenesis of herpes simplex virus.


Sources of entoptic stray light.

Sources of entoptic stray light.


Influence of stimulus luminance upon the upper speed threshold for the visual discrimination of movement.


Wavelength discrimination for point sources.


Comparison of scotopic, mesopic, and photopic spectral sensitivity curves.


Electronic multiflash generator for experiments in psychophysiological optics.


Variability of accommodation during steady fixation at various levels of illuminance.


The management of impacted teeth.

The management of impacted teeth.


Principles of alveolectomy.

Principles of alveolectomy.


Control of postoperative edema.

Control of postoperative edema.


Control of postoperative pain.

Control of postoperative pain.


Antibiotics in oral surgery: a review.

Antibiotics in oral surgery: a review.


Premedication and sedation for the surgical patient.


General anesthesia for the ambulatory patient.


Control of postoperative hemorrhage.

Control of postoperative hemorrhage.


Chronic osteomyelitis of the mandible: report of case.


Peripheral odontogenic fibroma with cementogenesis: report of case.


Mixed tumor in an eight year old child: report of case.


Sex differences in perceptual behavior.

Sex differences in perceptual behavior.


Artist and nonartist: a comparative study.


Conflict analysis of fantasy aggression.


Personality ratings as influenced by verbal stimuli; some negative findings.


Effects of impulsivity, introversion, and individual values upon association under free conditions.


Effects of success, failure, and social facilitation on level of aspiration in emotionally disturbed and normal children.


Individual differences in task performance under conditions of cognitive interference.


Status needs and performance under failure.


The effect of support and nonsupport on the performance of normal and feebleminded children.


The effect of epinephrine and aminophylline on the phosphorylase activity of perfused contracting heart muscle.


beta-Phenylisopropylhydrazine, a potent and long acting monoamine oxidase inhibitor.


Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan.


Electroencephalographic changes in the rat with mescaline intoxication.


The pyretogenic effect of 5-hydroxytryptophan and its comparison with that of ISD.


Cardiovascular actions of three choline esters of carboxyalkylimidazole.


Central respitory depressant action of hemicholinium in the cat.


The effect of histamine on neuromyal blocking agents.


Relative effectiveness of certain phenothiazine derivatives against death from shock produced in mice by tourniquet trauma.


A pharmacologic comparison of methocarbamol (AHR-85), the monocarbamate of 3-(o-methoxyphenoxy)-1,2-propanediol with chemically related interneuronal depressant drugs.


Some pharmacological effects of puffer poison.


The effects of chlorpromazine and chlorpromazine sulfoxide in normal and touriquet-shocked mice.


Physiological management compared with pharmacological and electrical stimulation in barbiturate poisoning.


The effects of pentobarbital-induced myocardial depression on cardiac electrolyte distribution.


The story of muscarine.

The story of muscarine.


The determination and excretion of polyhydroxy (catecholic) phenolic acids in urine.


The persistent antagonistic action of N-ally-1-(p-cyclohexyl-oxyphenyl) ethylamine to analgesic agents.


The percutaneous absorption of sulphanilamide.


A note on the suitability of the Indian frog (Rana tigrina) for the biological assay of tincture of digitalis.


A method for estimation of adrenaline and noradrenaline in urine.


Estimation of digoxin and digitoxin in Digitalis lanata.


A note on the identification of some antimalarial drugs.


The problem of sarcoidosis.

The problem of sarcoidosis.


Aids in the diagnosis of thyroid disease; the use of radioisotopes.


The use of trypsin in surgery.

The use of trypsin in surgery.


Thymoma; report of an unusual case.

Thymoma; report of an unusual case.


Peroral endoscopy in the Philippine General Hospital; a five-year survey.


Complete duplication of the right pelvis and ureter with an ectopic ureteral opening; report of a case.


Endocardial fibroelastosis: cardiac catheterization findings and diagnostic criteria for antemortem diagnosis.


Gestational variations in the composition of the foetal fluids and foetal urine in the sheep.


Renal function in the sheep foetus.

Renal function in the sheep foetus.


Effects of adrenalectomy on oxygen poisoning in the rat.


Effects of tocopherols, methylene blue and glutathione on the manifestations of oxygen poisoning in vitamin E-deficient rats.


Data for the calculation of the rate coefficients of sodium transfer by mouse ascites tumour cells.


The absorption of chloride ions from the retie-ulo-rumen sac.


The effects of certain physical factors and of the cardiac glycosides on sodium transfer by mouse ascites tumour cells.


Metabolism and sodium transfer of mouse ascites tumour cells.


The relationship of 5-hydroxytrýptamine to capillary permeability in the skin of the rat.


The distensibility of the blood vessels of the human calf determined by graded venous congestion.


The effect of variation in the concentration of individual extracellular electrolytes on the response of the sheep's parotid gland to Na+ depletion.


The reactions of the capacity blood vessels of the human hand and forearm to vaso-active substances infused intra-arterially.


Delayed increase of neuromuscular block in a series of faradizations of the motor nerve in myasthenic patients.


The simultaneous determination of both oxygen consumption and contraction response of an isolated muscle preparation employing a system for the continuous circulation of oxygen through the medium.


The alanine and oxo acid concentrations in mesenteric blood during the absorption of L-glutamic acid by the small intestine of the dog, cat and rabbit in vivo.


Effects of catechol amines present in peripheral tissues.


Helical configuration of smooth myofibrils.


Estimation of 5-hydroxytryptamine in blood and serum.


The effect of adrenaline and acetylcholine on the activity of single neurones in the reticular formation of the brain.


Urinary excretion of histamine in pregnant rats.


The innervation of mammalian neuromuscular spindles.


Active muscle vasodilatation and its relation to the flight and fight reactions in the conscious animal.


The interaction of evoked cortical responses.


Effect of electrical stimulation on the concentration of phosphorylated intermediary metabolites in mammalian non-myelinated fibres.


Afterpotentials following a single impulse in mammalian non-myelinated fibres.


Gonadotrophin incompatibility within species and strains.


Anaesthesia and sleeplike conditions produced by injections into the cerebral ventricles of the cat.


Release of sympathetic transmitter from the intestine of the cat.


A method for studying the effects of ions and drugs on the resting and action potentials in smooth muscle with external electrodes.


Experiments on perfusion of the ventricular system of the brain in the cat anaesthetized with chloralose.


Effects of drugs and anaesthetics on reanimation of ice-cold mice.


The unsaturated nature of irin and its interaction with lactones.


Experiments on the fate of histamine and acetylcholine after their injection into the cerebral ventricles.


The effect of alterations of plasma sodium on the sodium and potassium content of muscle in the rat.


The effects of stimulation of visceral afferent nerve fibres on somatic reflexes.


The site of action of procaine on the isolated spinal cord of the frog.


Photosensitive pigments from the retinae of certain deep-sea fishes.


The distribution of carotid and vertebral blood in the brain of the cat.


The sources of slow electrical activity in the frog's retina.


The effect of calcium and pH on the anaphylactic reaction.


The tissue distribution and oxidation of 14C-labelled chylomicron fat injected intravenously in rats.


Formation of plasma kinins by plasmin.

Formation of plasma kinins by plasmin.


Recording compensatory rolling of the eyes.


Apparatus for the study of visual size and shape constancy.


Interference between the responses of the human subject of two nearly simultaneous stimuli.


A new high-speed printing counter.

A new high-speed printing counter.


Resting potentials of diaphragm muscle after prolonged anoxia.


Use of the strain gauge plethysmograph in assessing the effect of certain drugs on the blood flow through the skin and muscle of the human forearm.


The reabsorption of urea by the rat kidney.


Visual discrimination following successive unilateral temporal excisions in monkeys.


In vitro measurement of inulin space of slices of rat skeletal muscle.


The velocity of combination of the first oxygen molecule with sheep haemoglobin.


The role of CO2 in the changes in forearm vascular resistance with anoxia.


Adaptation to localized warming and cooling.


Medullary potentials following stimulation of the orbital cortex.


Excitatory effects of vagal stimulation on cooled atria and their relation to adrenaline.


The increase in alkaline phosphatase activity of the duodenum and decrease in absorption of antibodies by the gut induced in young rats by deoxycorticosterone acetate.


Effect of oestradiol, progesterone and relaxin on the physical properties of the uterine cervix of the rat.


Changes in the liver during the induction of pregnancy toxaemia in sheep.


The excitation of regenerating nerves by acetylcholine.


Excitation and conduction in smooth muscle.


The action of procaine on fibres of different calibre in spinal roots of the cat.