Hypoplasia of the aorta: report of a case.


The digital circulation.

The digital circulation.


Myocardial infarct-like lesions and arteriosclerosis induced by high molecular substances, and prevention by magnesium salt.


Alice Hamilton.

Alice Hamilton.


Nitrogen dioxide indicator.

Nitrogen dioxide indicator.


Direct determination of boranes by the carmine method.


Determination of thorium in urine.

Determination of thorium in urine.


Clinical observations on coronary heart disease in epidemiological population studies.


Sampling effluent gases for particulate matter.


Evaluation and control of lead exposures in powder metallurgy operations.


Calibration of Alnor velometers.

Calibration of Alnor velometers.


Free silica dust concentrations measured in nine brick manufacturing plants.


A dynamic apparatus for preparing air-vapor mixtures of known concentrations.


Studies on aromatic amines. I. Preliminary observations on benzidine metabolism.


Tunneling operations in Massachusetts; hygienic aspects.


Regression versus peripheral control of differentiation in motor hypoplasia.


Chemical constitution and the toxic action of narcosis.


Reduction of air flow noises.

Reduction of air flow noises.


The pharmacological effects of magnesium arsenate phosphor upon experimental animals.


Some noise control methods used in industrial operations.


Medullary bone of laying chickens.

Medullary bone of laying chickens.


The antigen of Echinococcus.

The antigen of Echinococcus.


Histopathology of muscular dystrophy in the vitamin E-deficient hamster.


Coefficients of correlation for the weights and linear dimensions of the bones of 105 skeletons from Asia.


Effects of heat on the electrophoretic pattern of human serum proteins.


Ultraviolet spectrophotometric method for the determination of cholesterol.


Coagulation of blood; effect of calcium-binding by glutamyl peptide polymer.


A mechanized Natelson microgasometer.

A mechanized Natelson microgasometer.


The stability, after frozen storage, of an in vivo antigen-antibody bonding on red blood cells.


Determination of plasma fibrinogen by means of centrifugation after heating.


Intraglandular morules of the endometrium.


Needle biopsy of the liver and spleen in schistosomiasis; a histopathologic study.


Enlargement of the heart, cardiac failure, and loose, dry, scaly skin.


In memoriam: Charles Englander, 1890-1958.


A simplified tube procedure for the routine determination of bacterial sensitivity to antibiotics.


The use of the zinc sulfate centrifugation flotation technic as a routine diagnostic procedure.


Modified flame photometric method for the estimation of sodium.


Hinkleman's solution as a diluent for counting eosinophils.


A method for rapid dialysis.

A method for rapid dialysis.


Panel discussion on diseases of the esophagus.


Duodenal ulcer in children.

Duodenal ulcer in children.


An adjunct to diagnosis of the acute perforation of the upper gastrointestinal tract.


The use of small magnets to locate the tips of tubes in the gastrointestinal tract without fluoroscopy.


The gastroenterological aspects of periarteritis nodosa.


Enzyme activity in the serum and common duct bile of dogs.


Clinical evaluation of paper electrophoresis. VI. Normal serum lipid partitions and normal serum protein fractions as a function of age and sex.


Ulcerative colitis in a Southern general hospital and a Southern industrial-rural area; a concept of etiology and an attempt at a geography of the disease.


Significance of effectiveness of combined insulin-orinase treatment in maturity-onset diabetes.


Immunological considerations of an antigenic fraction from cultures of spirochetes isolated from cerebrospinal fluid of multiple sclerosis cases: preliminary report.


The effect of large doses of nicotinic acid on circulating lipids and carbohydrate tolerance.


Decrease in oxygen consumption associated with prolonged administration of the carbonic anhydrase inhibitor, acetazolamide (diamox).


The effect of L-triiodothyronine in pulmonary tuberculosis: a pilot study.


Therapy of metastatic trophoblastic tumors of the testis.


Clinical studies with penicillamine in hepatolenticular degeneration.


Intestinal parasitoses in Puerto Rican preschool children at Philadelphia, Pennsylvania in 1958.


Preliminary report on a new method for evaluating hypnotic drugs.


The effects of phenylbutazone and ACTH on gastrointestinal mucosa.


Simultaneous mitral commissurotomy and cross-polar plication (annuloplasty) in the treatment of combined mitral stenosis and regurgitation.


The significance of serial K determinations and of certain premature contractions in acute myocardial injury.


The predisposition to croup.

The predisposition to croup.


Recent developments in upper respiratory disease.


Treatment of the disease, alcoholism.

Treatment of the disease, alcoholism.


Quantitative relationship between insulin dosage and amount of carbohydrates utilized in diabetic persons.


Symmetry, asymmetry and meso-symmetry.

Symmetry, asymmetry and meso-symmetry.


Exacerbation of diabetes by excess insulin action.


Diabetogenic effect of hyperinsulinism.

Diabetogenic effect of hyperinsulinism.


Coagulation defects in liver disease and response to transfusion during surgery.


Motion study applied to urinalysis.

Motion study applied to urinalysis.


The scope and limitations of histochemistry.


The erythrocyte sedimentation test an historical review.


The significance of the direct-reacting fraction of serum bilirubin in hemolytic jaundice.


The natural history of esophageal varices; a study of 115 cirrhotic patients in whom varices were diagnosed prior to bleeding.


A six-month evaluation of an anabolic drug, norethandrolone, in underweight persons. I. Weight gain.


A six-month evaluation of an anabolic drug, norethandrolone, in underweight persons. II. Bromsulphalein (BSP) retention and liver function.


Cholestasis produced by the administration of norethandrolone.


Blood glucose and the liver.

Blood glucose and the liver.


Aortitis and aortic regurgitation associated with rheumatoid spondylitis.


Medical technology in a mid-western state: Kansas, 1957-58.


Genetic factors in diseases of connective tissue; a survey of the present state of knowledge.


A resumé on transaminase.

A resumé on transaminase.


DISSEMINATED lupus erythematosus.

DISSEMINATED lupus erythematosus.


Fifty-year survival following surgery of carcinoma of the stomach.


Toward a new definition of mental retardation.


Population trends in U. S. public institutions for the mentally deficient.


Teacher attitudes and information pertaining to mental deficiency; a comparison of regular grade and special class teacher responses to an attitude-information questionnaire.


Bilateral adrenalectomy for hypertensive vascular disease; hormonal requirements in the presence of renal insufficiency: body potassium in chronic hyperkalemia.


Dual occurrences of mongolism in two sibships.


The relation of parental attitudes and achievements of severely mentally retarded children.


A familial study in porphyrias and porphyrinurias.


The development of an interdisciplinary psychotherapeutic program in an institution for the mentally retarded.


The determination of serum globulin by the biuret method.


A clinical study of amoebiasis and its treatment in a selected section of institutional population.


A program of community education as an integral part of the functioning of an out-patient clinic for the retarded.


Rhythmic discrimination ability in mongoloid and normal children.


The galvanic skin responses of mentally retarded and other children in England.


Cortical satiation as a common factor in perception and abstraction: some postulated relationships based on the performances of atypical groups.


The adaptive significance of commonly described behavior of the mentally retarded.


Preparing egg base media for tubercle bacilli in the autoclave.


The influence of reward value on the stated expectancies of mentally retarded patients.


Driver education; asset or liability.

Driver education; asset or liability.


Motor task performance of high grade mentally retarded males as a function of the magnitude of incentive.


The Vale of Siddem revisited.

The Vale of Siddem revisited.


Performance of mentally deficient brain-injured children and mentally deficient familial children on construction from patterns.


Functional music, a therapeutic tool in working with the mentally retarded.


The brain-injured child; learning by living in a structured setting.


Family care boarding homes.

Family care boarding homes.


Parents' estimate of the intelligence of retarded children.


Clinical team treatment of a mentally retarded child and his parents: casework with the mother.


Relationships among physical, mental, and achievement measures in children of low, average, and high intelligence.


Arraignment, examination, and confinement of the mentally defective delinquent.


A pilot study in short-term play therapy with institutionalized educable mentally retarded boys.


Mesenchymal sarcomas of the uterus.

Mesenchymal sarcomas of the uterus.


An endocrine basis for endometrial carcinoma.


The association of diabetes mellitus and carcinoma of the endometrium.


Mixed mesodermal tumors; a report of 11 cases.


The histogenesis of carcinosarcoma (mixed mesodermal tumor) of the uterus as revealed by tissue culture studies.


Clinical team treatment of a mentally retarded child and his parents: group counseling and play observation.


Granular-cell myoblastoma of the vulva; review of the literature and report of four cases.


Sarcoma of the uterus; a report of 34 cases.


Glycogen content of the epidermis of the vulva in the presence of leukoplakia and of squamous-cell carcinoma; histochemical study of 98 specimens.


The value of a prepared culture medium in the diagnosis of Trichomonas vaginalis.


Simple rapid technic for serum total cholesterol.


The chain suture in operative gynecology.


Diagnosis of Trichomonas vaginalis vaginitis.


A new clamp for the Marshall-Marchetti operation.


Serum protein, lipid, and lipoprotein fractions in normal human pregnancy.


Unusual ovarian changes (hyperthecosis) in pregnancy.


Ectopic pregnancy: a review of fifty cases at Tripler U. S. Army Hospital.


Serum lactic dehydrogenase activity during pregnancy and in the newborn.


Ectopic pregnancy; a review of 481 cases.


Intrafollicular implantation; a case report of an early primary ovarian pregnancy.


Hypofibrinogenemia and ABO heterospecific pregnancy; a preliminary report.


Hypofibrinogenemia; report of a case managed by cesarean hysterectomy.


Old and new methods for induction of labor and of premature labor.


Oxytocic effects of intravenously administered hypertonic sodium chloride in human pregnancy at term.


The use of chlorpromazine in obstetrical analgesia.


Transvaginal pudendal nerve block; a new technique.


Erythrocytosis associated with a myomatous uterus.


Intramuscular perphenazine in labor; a study of 700 patients.


An obstetrical forceps which uses a new principle of parallelism.


Perphenazine suppositories in nausea and vomiting of pregnancy.


Spontaneous subarachnoid hemorrhage in pregnancy not complicated by toxemia.


A new obstetrical instrument.

A new obstetrical instrument.


Utopian obstetrics; in retrospect.

Utopian obstetrics; in retrospect.


Histology and mechanism of filtering operations.


Macular dystrophy of the cornea (Groenouw type II); clinicopathologic report of two cases with comments concerning its differential diagnosis from lattice dystrophy (Biber-Haab-Dimmer).


Bilateral homonymous hemianopsia; clinics in perimetry, No. 2.


Corneal transplants and blood types; a clinical study.


Surgical management of primary glaucoma; a description of a new technique.


Metastatic carcinoma to the retina.

Metastatic carcinoma to the retina.


Beta radiation; as an adjunct to glaucoma surgery in the Negro.


Studies on herpes simplex virus. IX. Corneal responses to repeated inoculation with herpes simplex virus in rabbits.


The ophthalmologist looks at the reading problem.


Reading failures and nonfailures in children with brain damage.


Metastatic disease of the optic nerve.

Metastatic disease of the optic nerve.


Percutaneous division of the external canthal ligament.


A portable sterilizer for the application of ethylene oxide gas in ophthalmology.


A successful Hummelsheim operation.

A successful Hummelsheim operation.


Chloroma of the orbit; a report of four cases.


Emboli of the central retinal artery after mitral commissurotomy.


Carbonic anhydrase and the formation of aqueous humor.


Biography: Bernard Becker.

Biography: Bernard Becker.


Protein dynamics in the eye studied with labelled proteins.


Changes in proteins and protein synthesis; in tryptophane deficiency and radiation cataracts of rats.


Hydrophilia of the orbital connective tissue in experimental exophthalmos.


The effect of methylene blue and certain other dyes on cation transport and hydration of the rabbit lens.


Additional observations on the bioelectric potentials of the lens.


In vitro lens studies. III. Lens potential.


Corneal water transport as measured with tritiated water.


Ocular changes induced by polysaccharides. II. Detection of hyaluronic acid sulfate after injection into ocular tissues.


Elevation of choroid by insertion of polyvinyl sponge; an experimental study.


Observations on accommodative convergence; especially its nonlinear relationships.


The effects of autonomic drugs on human flicker discrimination.


Studies on the anatomy and pathology of the peripheral cornea.


Acid mucopolysaccharide in the retinal pigment epithelium and visual cell layer of the developing mouse eye.


Industrial tear study; filter-paper electrophoresis of tears, with results of an industrial study from 1,000 specimens sent by mail.


The mast cells in the uveal tract of the eye and changes induced by hormones and avitaminosis-C.


An autoradiographic study on the uptake of S35-labeled sodium sulfate; in the eyes of normal, scorbutic, and hormonal treated guinea pigs.


Elaboration of bicarbonate ion in intraocular fluids. VI. Rabbit aqueous humor studies with NaHC14O3.


Outflow patterns of the cat eye.

Outflow patterns of the cat eye.


The effects of beta radiation on aqueous secretions in rabbits.


Tonometry; the pressure-volume relationship in the intact human eye at low pressures.


A contribution to the electroretinogram of retinitis pigmentosa.


Degeneration of the peripheral retina; report of an instructive case.


Cataract cases lost before surgery.

Cataract cases lost before surgery.


Johannes Müller on the inverted image: a new and unabridged translation.


Bulbar compressors; bilateral bulbar compression in the diagnosis and management of glaucoma.


In-vivo storage of corneal grafts.

In-vivo storage of corneal grafts.


A review of four hundred cases of vernal conjunctivitis.


Ataractic and antiemetic drugs in cataract surgery.


Clinical comparison of dichlorphenamide, chlorothiazide and sulocarbilate with acetazolamide in control of glaucoma.


Acid mucopolysaccharides in beef retina. I. Isolation and fractionation.


The effect of light on the level of reduced glutathione in retinal homogenates.


Pseudotumor cerebrior benign intracranial pressure.


Ocular complications of multiple myelomatosis.


The interactions between lens proteins and other proteins. IV. The behavior of the lens protein-protamine complexes in relation to electrostatic and enzymatic actions: changes associated with aging of the lens.


Unlisted nerve branches of the maxillary division of the trigeminal nerve (fifth cranial) which are related to nerve association of the lacrimal and salivary systems.


Electro-keratotome for the dissection of lamellar grafts.


Denuding the cornea in cataract surgery.


Tonography with restoration of the initial pressure.


Complications of ocular surgery.

Complications of ocular surgery.


Ophthalmic research.

Ophthalmic research.


A keratoscopic survey of 13,395 eyes.

A keratoscopic survey of 13,395 eyes.


The relationship between refractive state of the eye and intelligence test scores.


Partial cycloplegia and the accommodation convergence relationship.


Polyostotic hyperostosis in the female parakeet.


Subacute glomerulonephritis.

Subacute glomerulonephritis.


The morphologic elements in the early lesions of arteriosclerosis.


The structural basis of proteinuria in man; electron microscopic studies of renal biopsy specimens from patients with lipid nephrosis, amyloidosis, and subacute and chronic glomerulonephritis.


Phagocytosis of mast cell granule by the eosinophilic leukocyte in the rat.


Infrared spectrophotometry as a testing procedure of U. S. P. XVI.


A histochemical study of five oxidative enzymes in carcinoma of the large intestine in man.


Electromyographic study of certain leg muscles during movements of the free foot and during standing.


Electromyographic studies in cerebral palsy.


The effects of freeze drying on certain pharmaceutical preparations.


Alkaloidal iodides; their prescription incompatibilities; a preliminary study.


Thermoregulatory, brain and behavioral mechanisms during entrance into hibernation in the squirrel, Citellus beecheyi.


Kinetics of slow changes in membrane potential induced by direct current polarization of single nerve fibers.


Botryomycosis.

Botryomycosis.


Regulatory mechanisms, brain activity and behavior during deep hibernation in the squirrel, Citellus beecheyi.


Histochemical changes in liver succinic dehydrogenase during rapid growth following partial hepatectomy.


Dr. Charles G. Duncan retires.

Dr. Charles G. Duncan retires.


gamma-Aminobutyric acid: a substrate for oxidative metabolism of cerebral cortex.


Chromatolysis and vacuolation of specific diencephalic nuclei induced by actue pyrexia.


Plasma 17-hydroxycorticosteroid levels during electrical stimulation of the amygdaloid complex in conscious monkeys.


Factors in the pattern, timing and predictability of hibernation in the squirrel, Citellus beecheyi.


Localization of colloidal substances in vascular endothelium: a mechanism of tissue damage. I. Factors causing the pathologic deposition of colloidal carbon.


Effect of pulmonary congestion on vagal afferent activity.


Response of bone sodium to acute changes in extracellular fluid composition (cat).


Effects of controlled progressive hypotension on some spinal reflexes in the cat.


Correlation between brain cholinesterase and brain weight within tow strains of rats.


Comparison of total body and tissue losses of sodium and chloride with losses from sucrose space in salt-depleted rats.


Potassium and sodium content of uterine and seminal vesicle secretions.


Simultaneous flux of sodium into and out of the dog intestine.


Transport of p-aminohippurate from cell to lumen in kidney tubule.


Electrical and mechanical responses of uterine smooth muscle during anaphylaxis in vitro.


Steps in p-aminohippurate transport by kidney slices.


Effect of trimethylamine and its homologues on renal conservation of trimethylamine oxide by the spiny dogfish, Squalus acanthias.


Transfer of donor immunological reactivity to x-irradiated F 1 hybrid mice by injected parental bone marrow.


Flow of lymph from the canine liver.

Flow of lymph from the canine liver.


Prolongation of survival by parabiosis in strain 129 dystrophic mice.


Transport of radioiodide between thyroid gland and blood in mice and rats.


Effect of growth hormone on carbohydrate metabolism in normal and hypophysectomized dogs; studies with C14 glucose.


Early effects of total pancreatectomy on fat metabolism in the rat.


Experimental infection of mice and monkeys by Acanthamoeba.


Enhancement of adrenocorticotrophic activity. III. Protein hydrolysates and amino acids.


Oxidized tannin-azo method for protein in tissues.


The effect of cortisone and antibiotic agents on experimental pulmonary aspergillosis.


Metabolic alkalosis, a specific effect of adrenocortical hormones.


Extrarenal action of the adrenal cortex on electrolyte metabolism in nephrectomized and nephrectomized-eviscerated rats.


Peripheral blood epinephrine levels in dogs during intravenous infusion.


Relationship of adrenocortical and anterior pituitary function to fecal excretion of sodium and potassium.


Iron-59 metabolism as an index of erythropoietic damage and recovery in monkeys exposed to nuclear radiations.


Effect of cortisone and desoxycorticosterone on distribution of radioactive potassium in the adrenalectomized rat.


Adrenal blood flow in the albino rat.

Adrenal blood flow in the albino rat.


Effects of hemorrhage and hypoxia on febrile dogs and monkeys.


Serum electrolyte and hematocrit changes in young rabbits following hemorrhage.


Red blood cell volume and distribution after bleed-out in the rat as determined by Cr 51-labeled red blood cells.


Blood volume, bleeding volume and tolerance to hemorrhage in the splenectomized dog.


Determination of residual blood volume required for survival in rapidly hemorrhaged splenectomized dogs.


Cell volume, plasma volume, total blood volume and F cells factor in the rhesus monkey.


Plasma volume, cell volume, total blood volume and F cells factor in the normal and splenectomized Sherman rat.


Evaluation of variability in the cardiac output of dogs.


Autonomic vasomotor responses in the canine hepatic arterial and venous beds.


Effects of acute anoxia on cardiac contractility.


Relation between S-T segment elevation and experimental myocardial oxygen gradient.


Ventricular coupling induced by anodal or cathodal polarization during continuous direct currents in dog ventricle.


Critical closing pressure and vasomotor tone in the hind leg and the kidney of the cat.


Caudal intestine; observations for a study of the act of defecation.


A binocular sigmoidoscope for teaching purposes.


Sphincter-saving operations in the treatment of carcinoma of the rectum.


Hypertrophy of the pyloric muscle; a review of the literature on hypertrophy of the pyloric muscle in the adult with relation to the frequent occurrence of pyloric stenosis.


Therapeutic implications of differential effects of new phenothiazine compounds.


Heredity and eugenics.

Heredity and eugenics.


Neuropathology, endocrinology and biochemistry.


Electroencephalography.

Electroencephalography.


Clinical psychology.

Clinical psychology.


Physiological treatment.

Physiological treatment.


Psychosurgery.

Psychosurgery.


Child psychiatry and mental deficiency.

Child psychiatry and mental deficiency.


Alcoholism and geriatrics.

Alcoholism and geriatrics.


Clinical neurology.

Clinical neurology.


Epilepsy.

Epilepsy.


Mental health in education.

Mental health in education.


Industrial psychiatry.

Industrial psychiatry.


Psychiatric nursing.

Psychiatric nursing.


Rehabilitation and occupational therapy.


Psychiatric social work.

Psychiatric social work.


Family care and outpatient psychiatry.

Family care and outpatient psychiatry.


Forensic psychiatry.

Forensic psychiatry.


Administrative psychiatry.

Administrative psychiatry.


Military psychiatry.

Military psychiatry.


Psychiatric education.

Psychiatric education.


Clinical psychiatry and psychotherapy.

Clinical psychiatry and psychotherapy.


Model psychoses, their history, relevancy and limitations.


The influence of fertility control upon psychiatric illness.


Patterns of psychiatric practice.

Patterns of psychiatric practice.


Facilities for psychiatric education: survey of psychiatric departments in medical schools.


Unity and diversity of schizophrenia: clinical and logical analysis of the concept of schizophrenia.


A clinical study of Gilles de la Tourette's disease (maladie des tics) in children.


The communication of suicidal intent: a study of 134 consecutive cases of successful (completed) suicide.


An experimental study of the relative effectiveness of various components of electro-convulsive therapy.


Two-year fate study of pacatal-treated patients.


Music therapy for the mentally retarded.


Narco-stimulation.

Narco-stimulation.


Clinical results of triflupromazine (Vesprin) in 132 psychotic patients.


EEG changes with promazine.

EEG changes with promazine.


Preliminary report on triflupromazine (vesprin).


Psychological manifestations in a patient with chronic sensory deficits.


Successful termination of prolonged insulin coma of twenty days with one year follow-up.


Acute transitory psychotic reaction manifested after radioactive iodine treatment for hyperthyroidism.


Discharges from mental hospitals.

Discharges from mental hospitals.


A pre-Freudian complextheory.

A pre-Freudian complextheory.


Some drugs used in the treatment of mental disorders.


In memoriam: Harry J. Worthing; 1888-1958.


Freedom and psychotherapy.

Freedom and psychotherapy.


A confrontation technique used in psychotherapy.


Recent advances in the psychiatric diagnosis and treatment of phobias.


The fear of becoming insane.

The fear of becoming insane.


Psychotherapy for the aging.

Psychotherapy for the aging.


Mental contagion.

Mental contagion.


Existential group psychotherapy.

Existential group psychotherapy.


Observations on suicide occurring during group psychotherapy.


A note on Freud's neighbor.

A note on Freud's neighbor.


Emotion and intellect in psychotherapy.

Emotion and intellect in psychotherapy.


Radiation hazards.

Radiation hazards.


The development of community health services.


Local public health laboratory service in California.


Teaching health education to public health nursing aides.


Research in a home care program.

Research in a home care program.


Mottling of enamel in Mecca and the Arabian Peninsula; a survey and research study carried out in Saudi Arabia.


Complement-fixing antigens of living and inactivated poliovirus. II. Complement-fixing activity of poliomyelitis vaccine and its relation to immunogenic potency.


Organic phosphate insecticides; a survey of blood cholinesterase activity of exposed agricultural workers in Louisiana, 1957.


The responsibility of a university administration for health of students and faculty.


The community responsibility for medical care.


An epidemiological study of an outbreak of water-borne dysentery.


REPORT of the chairman of the Technical Development Board to the governing council 1957-1958.


EDUCATIONAL qualifications of public health veterinarians.


Positive roentgenograms plus positive sputum smears do not always equal pulmonary tuberculosis.


The changing roentgenologic picture in pulmonary tuberculosis under modern chemotherapy.


The Ghon focus of tuberculous reinfection.


Less familiar roentgen patterns of pulmonary granulomas; sarcoidosis, histoplasmosis and noninfectious necrotizing granulomatosis (Wegener's syndrome).


Roentgen aspects of blastomycosis.

Roentgen aspects of blastomycosis.


Pulmonary histiocytosis X (eosinophilic granuloma); report of a case.


Pulmonary paragonimiasis; an evaluation of roentgen findings in 38 positive sputum patients in an endemic area in Thailand.


Thromboembolism of the lungs.

Thromboembolism of the lungs.


The importance of chest roentgenography in the diagnosis of pulmonary embolism.


Pulmonary manifestations in collagen diseases.


Roenigen diagnosis of anomalous pulmonary venous drainage of right lung into inferior vena cava; report of three new cases.


Unusual roentgen manifestations of primary staphylococcal pneumonia in infants and young children.


The vanishing lung tumor; pulmonary hematoma.


Cystic lung lesions from metastatic sarcoma.


Cricothyroid bronchography with a polyethylene catheter; description of a new technique.


The average density of healthy lung.

The average density of healthy lung.


Cervicothoracic tumors: a technical aid to their roentgenologic localization.


Laryngocele: a case report.

Laryngocele: a case report.


Television contrast expansions of single roentgenograms.


An adaptor for developing 70 mm. roll film in the Eastman X-omat.


Plastic roentgen-ray phantoms.

Plastic roentgen-ray phantoms.


Radiation and the community: a new role for the radiologist.


Brigadier D. B. McGrigor.

Brigadier D. B. McGrigor.


Intrahepatic cholestasis.

Intrahepatic cholestasis.


Liver decompression by drainage of the common bile duct in subacute and chronic jaundice: report of seventy-three cases with hepatitis or concomitant biliary duct infection as cause.


Tumors of the extrahepatic biliary system.


Hepatic lobectomy.

Hepatic lobectomy.


Technic of cholecystectomy.

Technic of cholecystectomy.


Acute cholecystitis.

Acute cholecystitis.


The problem of retained common duct stones.


Multiple simultaneous complications of peptic ulcer.


The eosinophil and gastrointestinal carcinoma.


The prophylaxis and treatment of postpartum and postoperative ileus with pantothenyl alcohol.


Congenital internal hernia.

Congenital internal hernia.


Fluid and electrolyte balance following in juries to the head.


Open method treatment of burns with aerosol spray.


Carcinoma of the hypopharynx treated with one-stage reconstruction.


Giant pharyngoesophageal diverticulum.

Giant pharyngoesophageal diverticulum.


Acute intestinal obstruction secondary to Meckel's diverticulum with persistent obliterated omphalomesenteric duct.


Omphalocele with duodenal stenosis.

Omphalocele with duodenal stenosis.


Malignant melanoma of the breast.

Malignant melanoma of the breast.


Metastasis to a phalanx simulating infection in a finger.


A repair for loss of the tactile pad of the thumb.


Triple primary cancer.

Triple primary cancer.


Surgery court cases.

Surgery court cases.


The diagnostic corner.

The diagnostic corner.


Feeding habits of symbiotic mesostigmatid mites of mammals in relation to pathogen-vector potentials.


Organophosphorous compounds as residual treatments for adult mosquito control.


A method of comparing geographically distant snail populations by study of their shell composition.


The longevity of the unhatched miracidium of Schistosoma mansoni in the tissues of mice.


Host-parasite relationships in echinococcosis. I. Observations on the permeability of the hydatid cyst wall.


Host-parasite relationships in echinococcosis. II. Age resistance to secondary echinococcosis in the white mouse.


Histoplasmin, tuberculin and coccidioidin skin sensitivity in Liberian aborigines.


Virus transmission studies with Trinidadian mosquitoes II. Further observations.


A bentonite flocculation test for the diagnosis of hydatid disease in man and animals.


An evaluation of the hemagglutination and flocculation tests in the diagnosis of Echinococcus disease.


Probable biological control of schistosomiasis mansoni in a Puerto Rican watershed.


Persistent excretion of pyrimethamine following oral administration.


A correlative study of immunological tests for the diagnosis of hydatid disease.


Intestinal protozoans and helminths in Americans residing in southern Taiwan (Formosa).


Notes on paracholera in Sulawesi (Celebes).


Fractures of the hip.

Fractures of the hip.


The surgical treatment of marginal ulcer.


Changing concepts of gallstone formation.


Thymic cyst in the neck.

Thymic cyst in the neck.


Pancreatic cysts secondary to pancreatitis: diagnosis and surgical treatment.


Lower esophageal rings: report of fourteen cases.


Halothane (Fluothane): a clinical appraisal.


Interesting aspects in the treatment of burns.


The treatment of tetanus.

The treatment of tetanus.


The incidence of carcinoma in nodular goiter.


Finger tip injuries and their management.


Perforated peptic ulcer induced by prednisolone: report of three cases.


Individual management of patients with bleeding duodenal ulcer.


White blood cell changes following exposure to strangulation obstruction fluid.


Diagnosis and treatment of neck-shoulder-arm syndromes with medicolegal considerations.


Power lawn mower injuries.

Power lawn mower injuries.


[Experimental study of some aspects of the possible application of enzymatic products from Gibberella fujikuroi in agriculture].


Aspiration during induction of anesthesia; its prevention.


Some recent drugs useful in anesthesiology.


Some clinical aspects of the nonrebreathing valve. I.


Pentothal sodium: 1935-1957.

Pentothal sodium: 1935-1957.


Evaluation of a new analgesic agent; d-propoxyphene hydrochloride (darvon) in preanesthetic and postanesthetic management.


Rectal thiopental in new dosage forms: multidose suppositories or suspension in abbosert.


Anesthesia for ophthalmic surgery.

Anesthesia for ophthalmic surgery.


A new laryngeal spray.

A new laryngeal spray.


Choice of pressure-breathing apparatus.

Choice of pressure-breathing apparatus.


Anesthesia in relation to electroshock therapy.


WE SALUTE Henry K. Beecher.

WE SALUTE Henry K. Beecher.


Spontaneous pneumothorax of the newborn.


Some where's and why's of neuritis; a consideration of structures and causes.


The effect of Fluothane on acid-base balance.


Comparison of meprobamate, pentobarbital, and placebo as preanesthetic medication for regional procedures.


A study of blood flow, venous blood oxygen saturation, blood pressure and peripheral resistance during total body perfusion.


Performance characteristics of vaporizers for administration of Fluothane.


Caudal analgesia for vaginal delivery. I. Organization, medication, technique, maternal and perinatal infant mortality.


Performance of absorbents: continuous flow.


Resuscitation under anesthesia: some interesting early reports.


Some effects of hypocapnea on the development of ether anesthesia in the dog.


Preanesthetic medication for children: comparison of oral and intramuscular routes.


Infrared analysis for carbon dioxide in respired gases containing cyclopropane and ether.


Succinylcholine drip during craniotomy.

Succinylcholine drip during craniotomy.


Cardiovascular effects of some commonly used pressor amines.


Malpractice as related to the anesthesiologist.


Geographical comparison between parturients in Northern and in Southern Karelia.


Agranulocytosis complicating pregnancy.

Agranulocytosis complicating pregnancy.


Spasmodic torticollis.

Spasmodic torticollis.


Injuries to amputees.

Injuries to amputees.


Distribution of colloidal radioactive chromic phosphate (CRP32O4) after intrapleural injection in the guinea pig.


Comparative study of the distribution of intrapleurally injected colloidal radioactive chromic phosphate (CrP32O4) and gold (Au198) in the guinea pig.


The prognostic significance of age and parity in obstetrics.


The importance of the liver changes in intestinal obstruction caused by gallstones; report of eleven cases.


Abscess of the spleen; report of a case.


Regional lymph node metastasis in primary bronchogenic carcinoma; a pathological study of 100 resected cases.


Potassium excretion in surgical patients; nocturnal urinary potassium excretion as an index of potassium deficiency.


[Selective medium permitting the rapid identification & counting of Streptococcus faecalis. II].


Studies on the subcommissural organ in some domestic animals; with reference to secretory phenomena.


[The therapeutic use of levopromazine in psychiatry].


[Study of levomepromazine in the systematic treatment of 61 cases].


[Initial results of iproniazid therapy of depressive states].


Determination of plasma glutamine by high-voltage paper electrophoresis.


The gastro-intestinal tract of the newborn. I. Cineradiographic findings.


Muscular weakness in early infancy; report of three cases.


Clinical symptoms of respiratory disorders in the newborn. IV. Symptoms of congenital malformation of the heart.


Intravascular red cell aggregation in children with heart disease.


Intravascular red cell aggregation in children with benign and malignant tumors.


Thrombocytopenia associated with intestinal haemangioma in a child; report of a case cured by surgery.


The rate of growth in length of the long bones, in certain pathological conditions; an x-ray study.


New drugs for the treatment of hypertension.


The role of thoracotomy in the differential diagnosis of pleural effusion.


Effects of sublingual nitroglycerin on pulmonary arterial pressure in patients with left ventricular failure.


The problem of the diagnosis of gastric lesions.


The indications for surgery in pulmonary tuberculosis.


Increasing clinical significance of alterations in enzymes of body fluids.


Sickle cellhemoglobin D disease.

Sickle cellhemoglobin D disease.


Salt metabolism in hypertension.

Salt metabolism in hypertension.


Psychosomatic research: problems in methodology.


Benign familial icterus: a report of three cases.


Russian research on arterial hypertension.


Dermatomyositis with pulmonary lesions.

Dermatomyositis with pulmonary lesions.


The syndrome of exophthalmos, hypertrophic osteoarthropathy and localized myxedema: a review of the literature and report of a case.


Sarcoidosis with vertebral involvement.

Sarcoidosis with vertebral involvement.


Severe infectious mononucleosis treated with prednisolone.


Ventricular tachycardia: a case requiring massive amounts of procaine amide (pronestyl) for reversion.


Unilateral renal ischemia as a cause of hypertension.


Basic biodynamics.

Basic biodynamics.


The application of engineering technology to the simulation of human motions.


Reactions to loss of limb: physiological and psychological aspects.


The body image as related to phantom sensation: a hypothetical conceptualization of seemingly isolated findings.


Comments on biological aspects of amputation.


The role of the engineer in prosthetic development.


Problems in interdisciplinary coordination and communication.


Interdisciplinary research in rehabilitation.


Methods and sources of stimulating interdisciplinary research.


Problems in supervision and future prospects of interdisciplinary research.


Analysis of the hemiplegic gait.

Analysis of the hemiplegic gait.


Psychological adjustment patterns of the disabled.


Objective recording and biomechanics of pathological gait.


Comments on interdisciplinary contributions in the care of the neuromuscularly disabled.


Contributions of the physical sciences to problems of neuromuscular dysfunction.


Engineering research on problems resulting from sensory loss.


Psychological aspects of sensory disability.


Research in sensory disorders.

Research in sensory disorders.


Pulsatile activity in total transplantation of fetal mouse hearts.


Clinical application of embryonic skin grafts.


Studies of adult and embryonic skin homografts on conditioned or normal rabbits, with emphasis on the possible role of the ground substance.


Fetal tissue homografts.

Fetal tissue homografts.


Embryonic parabiosis and related problems.


Homotransplantation of developing tooth buds in the rat.


Behavior of skin grafts exchanged between parents and offspring.


Comparative immunology and the phylogeny of homotransplantation.


Genetics of fin transplantation in xiphophorin fishes.


Genetics of tissue specificity.

Genetics of tissue specificity.


Induced immunity to cancer cell homografts in man.


Histocompatibility in inbred strains of guinea pigs.


Cell-bound antibodies in transplantation immunity.


Lymphatic repair and the genesis of homograft immunity.


Studies of transplantation immunity in hamsters.


Reactions of skin homografts with specific immune sera.


The vascularization of skin homografts and transplantation immunity.


Host-graft interrelationship and the effects of injections of organ homogenates and of cells upon the testes of experimental animals.


Some reactions of H-2 antibodies in vitro and in vivo.


Observations on the genetic relationships affecting the transplantability of skin in inbred mice.


The nature of tissular antigens, with particular reference to autosensitization and transplantation immunity.


Effects of protein deficiency and massive internal irradiation of the reticuloendothelial system on antibody reactions in kidney homotransplantation.


Specific desensitization of guinea pigs with delayed hypersensitivity to protein antigens.


Antigens responsible for bone marrow transplantation immunity.


The erythrocyte-borne antigen in tumor immunity.


Homologous whole blood as an agent for enhancement of skin grafts in the adult rabbit: a preliminary report.


Studies on the reaction of injected homologous lymphoid tissue cells against the host.


Graft-versus-host reaction and acquired tolerance in tissue homotransplantation; introduction: problems in transplantation immunity.


Effect of preinjection of homologous leukocytes on homotransfer of lymph node cells in rabbits.


Tolerance and homologous disease in irradiated mice protected with homologous bone marrow.


Studies of immunological tolerance to nervous tissue in rats.


Studies on bone marrow homotransplantation in x-irradiated rabbits.


The homograft reaction in x-irradiated rabbits treated with homologous bone marrow: a preliminary report.


A study of the graft-versus-host reaction in transplantation to embryos, F1 hybrids, and irradiated animals.


Acquired tolerance to homografts and heterografts in the rat.


The use of globulins as a means of inducing acquired tolerance to parabiotic union.


Unexpected manifestations of induced tolerance to skin homografts in the chicken.


Barber-surgeons in Great Britain and Ireland.


Prostatic obstruction.

Prostatic obstruction.


Hypothermia as an aid to surgery.

Hypothermia as an aid to surgery.


Variation and selection within tumour cell populations.


A technic for subtotal excision of the trachea and establishment of a sternal tracheostomy.


Strangulated femoral hernia: a review of 170 cases.


Contact splint survey.

Contact splint survey.


The environmental distribution of Staphylococcus aureus in an operating suite.


Effect of chlorpromazine on survival time and mesenteric blood flow in experimental shock.


Neurological sequelae of brachial plexus nerve block.


Complete severance of the common bile duct due to blunt trauma: a case report.


Tolerance of skin grafts to radiation: a study of postmastectomy irradiated grafts.


Observations of the blood amylase level in the dog with experimentally produced simple and strangulated obstructions of the small intestine.


Use of the carbon are and burning magnesium as thermal sources for experimental burns.


Comparison of air, oxygen and carbon dioxide embolization.


Lymphosarcoma of the small intestine in infancy and childhood.


Clinical experiences with fluothane; a new nonexplosive anesthetic.


Polyurethane polymer, its use in osseous lesions: an experimental study.


Appendectomy during right inguinal herniorrhaphy.


Congenital diverticula of the pericardium.


Intravenous leiomyomatosis of the uterus and pelvis: case report.


Skin necrosis complicating femoral arteriography.


Regional enteritis with free perforation: report of a unique case.


Acute perforated tuberculous enteritis: surgical treatment.


Factors that may influence the infection rate of Glossina palpalis with Trypanosoma gambiense. I. The age of the fly at the time of the infected feed.


The protection against trypanosomiasis conferred on cattle by repeated boses of antrycide, alone or with Trypanosoma congolense.


Aircraft applications for anopheline control: prevention of a seasonal increase with a granulated formulation of dieldrin.


Suramin complexes. IV. Ethidium bromide complex: a largescale laboratory trial of its prophylactic activity in cattle.


Suramin complexes. V. Ethidium complex: attempts to overcome the injection-site reaction in cattle.


The inheritance of DDT resistance in Aëdes aegypti


Salt-deficiency heat exhaustion.

Salt-deficiency heat exhaustion.


Notes on the culicine mosquitoes of Singapore. IV. The Aëdes niveus subgroup (Diptera, Culicidae): introduction and description of five new species and of one new subspecies.


Sterilization of tsetse-flies (Glossina) by gamma irradiation.


Observations on the innervation of the hepatic blood-vessels.


The demonstration of proteolytic enzyme activity of Entamoeba histolytica by the use of photographic gelatin film.


Notes on a new species of Myonyssoides (Acarina, Laelaptidase) from a mole-rat.


Effect of heparin in vivo on the release of microfilariae of Wuchereria bancrofti into the peripheral blood.


The formation of septa during development of trypanosomes.


The growth of yeasts in grape juice stored at low temperatures. I. Control of yeast growth in commerical operation.


The growth of yeasts in grape juice stored at low temperatures. II. The types of yeast and their growth in pure culture.


The growth of yeasts in grape juice stored at low temperatures. III. Quantitative studies on growth of natural mixed inocula.


A rapid test for detecting Staphylococcus aureus in food.


Bacterial changes in the rumen during the onset of feed-lot bloat of cattle and characteristics of Peptostreptococcus elsdenii n. sp.


An occurrence of petite colonie mutation in an alcohol distillery yeast.


A note on the stability of clostridia when held in continuous culture.


Inhibition of Clostridium botulinum and molds in aged, surface ripened cheese.


Chemical analysis of x-ray mutants of Torulopsis utilis var. major.


Antigenic relationships in seven strains of Tetrahymena.


Toxicity to chicks of histamine formed during microbial spoilage of tuna.


Agitation-aeration in submerged fermentation. I. A comparative study of the sulfite and polarographic methods for measuring oxygen solution rates in a fermentor.


Agitation-aeration in submerged fermentation. II. Effect of solid disperse phase on oxygen absorption in a fermentor.


[Meprobamate in pediatrics].

[Meprobamate in pediatrics].


Study of 2,3-butanediaol formation by Serratia marcescens.


Sporobolomyces marcillae nov. spec., isolated from the air.


Nuclear structure and mitosis in the Englenineae.


Hermann O. L. Fischer: a tribute on his 70th birthday. Preceding.


Studies on the conversion of deoxyuridylic acid to thymidylic acid by a soluble extract from rat thymus.


Synthesis of unsaturated alpha-phosphatidic acids and alpha-bisphosphatidic acids; cardiolipin substitutes. IV.


Extrahepatic oxidation of albumin-bound palmitic acid in the diabetic rat; its regulation by insulin.


[Thixotropic effect of ultrasonics].

[Thixotropic effect of ultrasonics].


The effect of variation in molecular weight on the antigenicity of dextran in man.


The action of pancreatic lipase on stereoisomeric triglycerides.


Terminal components of ribonucleic acids.


Glycolaldehyde phosphate.

Glycolaldehyde phosphate.


Effect of varying type and quantity of dietary fat on the fecal excretion of bile acids in humans subsisting on formula diets.


The nature of trichloroacetic acid-soluble derivatives of D-alanine in Streptococcus faecalis.


The synthesis of 1,5-di-O-trityl-3,4-O-isopropylidene-D-ribulose.


The formation of 1,6-anhydro-alpha-D-galactofuranose and 1,6-anhydro beta-D-galactopyranose by the action of acid on D-galactose.


2,5-Anhydro-L-idose, a product of the acid hydrolysis of 1,2-O-isopropylidene-5, 6-anhydro-alpha-D-glucofuranose.


2-Deoxy-D-ribose. I. A simplified preparation of 2-deoxy-D-ribose based on treatment of alpha-D-glucose monohydrate with solid calcium hydroxide.


Studies on pituitary lactogenic hormone. XIX. Countercurrent distribution.


Yeast uridine diphosphogalactose-4-epimerase, correlation between activity and fluorescence.


Regulation of threonine biosynthesis in Escherichia coli.


Enzymic synthesis of uridine diphosphate glucuronic acid and uridine diphosphate galacturonic acid with extracts from Phaseolus aureus seedlings.


Studies on the amino acid sequence of tobacco mosaic virus (TMV) protein. I. Fractionation of products of tryptic hydrolysis by countercurrent distribution.


Reduction of the products of periodate oxidation of carbohydrates. VII. the constitution of glycogen.


Enzymic preparation and characterization of an alpha-L-beta-methylaspartic acid.


Phosphorus content of tobacco mosaic virus.


Fluorokinase and pyruvic kinase.

Fluorokinase and pyruvic kinase.


On the importance of being ionized.

On the importance of being ionized.


Physical properties of crystalline fluorokinase.


A comparison of C14-labeling patterns in deoxyribose and ribose in mammalian cells.


Synthesis of N-trityl peptides by the Curtius azide method.


Cyciltol oxidation by Acetobacter suboxydans. II. Additional cyclitols and the third specificity rule.


Partition column chromatography of insulin in 2-butanolaqueous acid systems.


The synthesis of the histidine analog of the vasopressins.


Solubility of tissue phosphatides in acetone.


On the mechanism of enzyme action. LXVIII. The cellobiase component of the cellulolytic enzyme system of Poria vaillantii.


Antibiotics as tools for metabolic studies. I. A survey of toxic antibiotics in respiratory, phosphorylative and glycolytic systems.


The path of carbon in photosynthesis. XXIII. The tentative identification of erythrose phosphate.


The effects of parenteral administration of calcium on gastro-intestinal secretions and hydrochloric acid formation.


Cardiovascular reactivity to norepinephrine in metacorticoid hypertensive rats and the effect of pretreatment with 17 alpha-propyl-4, 5 beta-dihydro-19-nortestosterone.


Concerning the theory of receptors in pharmacology; a rational method of estimation of pAx.


A study of the cardiovascular actions of 2-chloroadenosine.


On the pharmacology of traces of fluoride.


In vivo observations with radioactive trypsin.


Effect of respiratory stimulants on minute volume of rabbits.


Pharmacology of diammonio esters.

Pharmacology of diammonio esters.


Effect of sarin on the cardio-inhibitory, vasomotor and respiratory centers of the isolated head in dogs.


[Value of quantitative determination of blood quinidine in the reduction of auricular fibrillation; concerning 66 reductions & 585 determinations].


Pediatric progress during the last twenty-five years.


Coxa piana.

Coxa piana.


The practice of physical medicine and rehabilitation.


Congenital cerebral aneurysms and coarctation of the aorta.


Plantar wart treatment with ultrasound.

Plantar wart treatment with ultrasound.


An apprasial of American training in physical medicine and rehabilitation for foreign medical personnel: retrospect and aftermath.


Trochanteric bursitis: management.

Trochanteric bursitis: management.


Case report: rehabilitation of patient with paralysis and advanced flexion deformities of lower extremities.


A work adjustment center in vocational rehabilitation.


Certain experimental observations on a pulsed diathermy machine.


Cortical sensory defects causing disability.


Etiology and pathology of ischemic ulcers.


Acute cerebrovascular accidents: statistical considerations, diagnostic methods and treatment.


A study of the effectiveness of a nylon nonrubberized elastic stocking.


Structure of the zona glomerulosa of the adrenal cortex as an indication of age and sex variations in normal mice.


[Giant intracanalicular fibroadenoma or cystosarcoma phyllodes].


The treatment of cleft lip.

The treatment of cleft lip.


Free tendon grafting in the treatment of flexor tendon lesions in thumb and fingers.


Recurrent basal cell carcinoma of the skin.


Fibrous ankylosis of the extended knee.

Fibrous ankylosis of the extended knee.


Simple mastectomy combined with radiotherapy in the treatment of cancer of the breast; results in 109 patients.


Cancer of the duodenopancreas. II. Technique of duodenopancreatectomy.


Medical Society of the United States and Mexico: introduction; 1958 meeting.


Thoracic aortography in atresia of the pulmonary artery.


Congenital abnormalities of the coronary arteries.


HARRY H. KUHLMAN; 1923 to 1958.

HARRY H. KUHLMAN; 1923 to 1958.


Complications of breast surgery.

Complications of breast surgery.


Glaucoma screening at Arizona State Fair.


The physician's role in the social security disability program.


1958 REVISION of diagnostic criteria for rheumatoid arthritis.


The presence of the rheumatoid factor in sera from patients with syphilis.


Osteitis condensans ilii; a comparison with the acetabular condensation observed in cases of osteoarthritis secondary to subluxation of the hip.


Therapeutic exercise in rheumatoid arthritis.


Cellular aspects of the cell-virus relationship.


Lipoid nodules in chronic rheumatoid arthritis.


Animal cells and microbiology.

Animal cells and microbiology.


Quantitative studies of complement fixation.


Tuberculosis of fish; a review of the literature with a description of the disease in salmonoid fish.


[Individual and age-connected variabilities of the deep femoral artery].


Characterization of the bacterial enzyme thromboplastinase.


The effect of pentachlorophenol on the adenosinetriphosphatase and contractile properties of psoasmuscle preparations.


Ascorbic acid and photosynthesis. I. Monodehydroascorbic acid reductase of chloroplasts.


The effect of dinitrophenol on magnesium-activated adenosinetriphosphatase.


The role of iron in beefheart succinic dehydrogenase.


Effect of serotonin on phenol oxidase from the liver fluke Fasciola hepatica and from other sources.


Some effects of pressure on a phenylglycosidase.


The oxidation of 2-aminopurine by mammalian xanthine oxidase.


The adenosinetriphosphatase activity of particulate enzyme systems.


Stoichiometric studies on the action of laccase.


The incorporation of amino acid carbon by Rhodospirillum rubrum.


Electron distribution in some high energy phosphates and transfer of energy from catabolism to anabolism.


Time study of incorporation in vivo of 32P-orthophosphate into phosphatides of rat tissues.


Structure and properties of microsomal nucleoprotein particles from pea seedlings.


Increase of cellular constituents in x-irradiated mammalian cells.


Interaction of myosin B with adenosine triphosphate, a flow-birefringence study.


The soluble proteins of bovine hide. II. Extraction by aqueous sodium phosphate and half-saturated lime.


L'ascorbic acid; a possible intermediate in carbohydrate metabolism in plants.


Further studies of microsomal DPNH cytochrome C reductase.


A radiation-sensitive mutant of Escherichia coli.


Action of tobacco-leaf ribonuclease on polyuridylic and cytidylic acids.


Relation between the ability of various compounds to block nervous conduction and their penetration into a monomolecular layer of nerve-tissue lipoids.


Magnetic susceptiblity of oxidized and reduced laccase.


The incorporation of adenosine monophosphate into two different soluble ribonucleic acid fractions of rat liver.


The phosphatide composition of rat tissues.


Enzymic transfer of pyruvate to uridine diphosphoacetylglucosamine.


The conversion of 16-14C-17 beta-estradiol to estriol by isolated rat livers.


The biosynthesis of the porphyrin-like moiety of vitamin B12. II. The origin of the methyl groups.


Reactions involving the amide and carboxyl groups of tobacco mosaic virus (TMV) protein.


Studies on the structure of hemoglobin. I. Physicochemical properties of human globin.


Activation of cytochrome oxidase by a mitochondrial lipoprotein.


Metabolism of hexuronates and 5-ketohexonates by Erwinia carotovora.


The function of calcium in the potassium permeability of human erythrocytes.


The optical rotatory properties of bacterial gamma-poly-D-glutamate.


Oxidative photosynthetic phosphorylation.


Liberation of phenol from diphenylphosphoryl chymotrypsin.


Nature of the inactivation by isooctane extraction of enzymes of the respiratory chain.


The effect of urea on the activity of penicillinase.


Fluid movements across wall of rat small intestine in vitro.


Enzymic formation of inosinic-adenylic pyrophosphate.


3-Ketoglycosides, new intermediates in the bacterial catabolism of disaccharides.


Biosynthesis of a metabolically active citrulline-like material unrelated to carbamyl aspartate and carbamyl phosphate.


The hemolytic effect of primaquine and related compounds: a review.


The collection, storage and preparation of viable cadaver marrow for intravenous use.


Thrombocytopenia with a circulating platelet agglutinin, platelet agglutinin, platelet lysin and clot retraction inhibitor.


Albinism associated with hemorrhagic diathesis and unusual pigmented reticular cells in the bone marrow: report of two cases with histochemical studies.


The response of eosinophils to total-body x-radiation of the monkey.


The Pelger-Huët anomaly in three families and its use in determining the disappearance of transfused neutrophils from the peripheral blood.


Glucose metabolism of leukocytes and red blood cells in bone marrow aplasia.


Remarks on the pathogenesis and aetiology of acute leukaemia.


[Additions to the pharmacopeia; proposed galenical monographs].


The prognostic value of the muscle biopsy in the floppy infant.


Endogenous hypoglycaemia.

Endogenous hypoglycaemia.


Some autonomic concomitants of ictal automatism; a study of temporal lobe attacks.


Vestibulogenic seizures; a consideration of vertiginous seizures, with particular reference to convulsions produced by stimulation of labyrinthine receptors.


Torulosis of the central nervous system in Britain.


On familial ataxia, neural amyotrophy, and their association with progressive external ophthalmoplegia.


Dorsal spinal root afferents to Clarke's column.


The fasciculus intermediolateralis of Loewenthal in man.


The meaning of postulational psycho-physical parallelism.


Acetylcholine and the pulmonary circulation in mitral valvular disease.


Constrictive pericarditis.

Constrictive pericarditis.


Tomography of calcified aortic and mitral valves.


Electrocardiographic changes during positive acceleration.


Observations on hypoxic pulmonary hypertension.


The incidence of congenital heart disease in children born in Gothenburg 1941-1950.


Some possible causes of congenital heart malformation.


The genetics of congenital heart disease and situs inversus in sibs.


Primary pulmonary hypertension in three sibs.


Post-partum heart disease.

Post-partum heart disease.


Congenital diverticulum of the left ventricle.


A stable cuvette of high sensitivity for indicator dihition curves.


The effect of thyrotoxicosis on the electrocardiogram.


The myocardial factor in mitral valve disease.


Tricuspid incompetence following successful mitral valvotomy.


Polythelia in cardio-arterial disease.

Polythelia in cardio-arterial disease.


Sir Arnold Stott.

Sir Arnold Stott.


Case reports; dissecting aneurysm of the aorta associated with congenital pulmonary valvular stenosis.


Cardiac involvement in erythema nodosum associated with pulmonary tuberculosis.


Idiopathic myocarditis involving the bundle of His.


Halothane and rebreathing.

Halothane and rebreathing.


Halothane concentrations obtained with a Fluotec vaporizer.


Circulatory dynamics during light halothane anaesthesia.


Halothane as an adjuvant to nitrous oxide in outpatient dental anaesthesia.


Modern considerations in neurosurgical anesthesia.


Professor Simpson's pamphlets on chloroform. II. Superinduction of anaesthesia in natural and morbid parturition.


The causes and management of cerebral palsy in childhood.


Osteogenic sarcoma.

Osteogenic sarcoma.


The physiology of highspeed flight. I.

The physiology of highspeed flight. I.


Oral administration of iron.

Oral administration of iron.


The therapeutic value of the cardiac glycosides.


The importance of the umbilical cord as a reservoir of infection.


The significance of lumps in the neck.

The significance of lumps in the neck.


The detection and treatment of glaucoma.


Convulsions in childhood.

Convulsions in childhood.


Geriatrics.

Geriatrics.


The skin clinic.

The skin clinic.


The treatment of some common disorders. III. Cervical spondylosis.


Paronychia or perionychia: aetiological aspects.


Lipoid dermatoarthritis (reticulohistiocytosis).


Occupational dermatitis; its prevention, with special reference to barrier substances.


Subacute nodular migratory panniculitis.


A case of urticaria solaris studied with a monochromator.


Primary systematised amyloidosis with striking skin changes.


The effects of local cooling on the cutaneous blood flow in normal and erythrocyanotic patients.


Histological changes in the lung in diseases associated with pulmonary venous hypertension.


Segmental pulmonary artery aneurysms with peripheral venous thrombosis.


Steroid therapy in pulmonary fibroses.

Steroid therapy in pulmonary fibroses.


Idiopathic pulmonary haemosiderosis in adults and adolescents.


The prognosis in syphilitic aortic aneurysm after treatment with penicillin.


Pulmonary bullae and infection.

Pulmonary bullae and infection.


Plasmacytoma of lung and stomach.

Plasmacytoma of lung and stomach.


The erythrocyte sedimentation rate in plasma detergent mixtures.


Laryngeal tuberculosis.

Laryngeal tuberculosis.


The diagnosis of tuberculous pleural effusion.


The effects of prednisolone on chronic drug resistant pulmonary tuberculosis in Kenya Africans.


A tuberculin survey in the island of Montserrat, British West Indies.


The training of the greatest of chest physicians: Laennec.


Industrial health: meeting the challenge.


The response to Heinz bodies in the rat.


The toxicity of epichlorhydrin vapour.

The toxicity of epichlorhydrin vapour.


Investigations concerning the pre-radiological stage of silicosis.


Toxic solvents: a review.

Toxic solvents: a review.


The dust content of the lungs of coal workers from Cumberland.


Quarry Bank Mill. 2. The medical service.


Respiratory function and disease among workers in alkaline dusts.


The royal oculist.

The royal oculist.


Functional spasm of accommodation.

Functional spasm of accommodation.


Proptosis as the first sign of orbital sepsis in the newborn.


Significance of colour change in the cornea.


Myectomy of the inferior oblique; report on 100 cases.


Metabolism of the developing retina. I. Aerobic and anaerobic glycolysis in the developing rat retina.


In vitro swelling of the kitten retina induced by sodium fluoride inhibition.


Haemorrhage into the lens; a complication of intra-ocular surgery.


Mucopolysaccharide in the secretion of vernal conjunctivitis; its use as a diagnostic test.


Allergy to antivenine serum.

Allergy to antivenine serum.


Modified Ridley lenses.

Modified Ridley lenses.


Chiasmal arachnoiditis.

Chiasmal arachnoiditis.


Malignant glaucoma.

Malignant glaucoma.


Two new surgical instruments.

Two new surgical instruments.


Pharmacological activity of 5-phenyl-1:3:4-thiadiazole (L 1538), 2-amino-5-phenyl-1:3:4-thiadiazole (L 1460) and 2-amino-5-(2'-thienyl)-1:3:4-thiadiazole (L 1458). The pharmacological actions of 5-phenyl-1:3:4-thiadiazole (L 1538), 2-amino-5-phenyl-1:3:4-thiadiazole (L 1460) and 2-amino-5-(2'-thienyl)-1:3:4-thiadiazole (L 1458) have been studied and compared with those of other muscular relaxant drugs. The three compounds have paralysing effects in mice, rats, cats, and dogs. They block the tonic component of maximal electroshock seizures and protect against strychnine, though not against leptazol-induced convulsions in mice. Like other centrally acting paralysing drugs, they depress spinal polysynaptic transmission in doses which leave monosynaptic transmission relatively unaffected. The rigidity of the decerebrate cat is reduced but not always abolished. The compounds do not induce synchronization in epidural electroencephalogram recordings. In doses not greatly affecting muscular tone and spontaneous activity, they prolong the hypnotic effects of pentobarbitone and other barbiturates in mice. Autonomic functions are only slightly affected. The similar actions of substituted thiadiazoles and 2-amino-benzothiazoles confirm a previous hypothesis that pharmacological equivalence may result either from condensing heterocyclic nuclei with aromatic nuclei or from introducing aryl substituents into them.


Cardiac output during excitation of chemoreflexes in the cat. In cats under chloralose anaesthesia the reflex fall of blood pressure and heart rate caused by injection of veratrine, amidines, diphenhydramine, or ethyl acetoacetate was accompanied by a fall in cardiac output. After veratrine and amidines there was a fall in mean pulmonary arterial pressure and after veratrine no significant change in pulmonary vascular resistance. After diphenhydramine and ethyl acetoacetate there was a rise in mean pulmonary arterial pressure and after diphenhydramine an increase in pulmonary vascular resistance. The effects of veratrine and amidines, but not those of diphenhydramine and ethyl acetoacetate, were abolished by section of the vagi. The main change leading to the fall of cardiac output after amidines was bradycardia.


The distribution of methylpentynol and of methylpentynol carbamate in tissues and body fluids of cats. A method is described for the estimation of methylpentynol and methylpentynol carbamate in body fluids and tissues. After intravenous administration, the distribution of these drugs throughout the body was found to be similar to that of ethanol. They entered cells, and crossed the blood-brain barrier and the placenta. They were excreted or secreted into the saliva, milk, gastric secretion, aqueous and vitreous humour, amniotic liquor, bile and urine. Methylpentynol was found in the expired air. Calculation of the volume of distribution and measurement of concentration in the tissues showed that both drugs were only slowly metabolized or excreted, suggesting the possibility that blood concentrations might rise cumulatively over a period of days.


The pharmacological actions of some murexine-like substances. Four choline esters of imidazole acids, two imidazole ethers of choline and thirteen ringsubstituted murexine-like compounds were compared with murexine for their muscle-paralysing and their nicotine-like effects. Dihydromurexine appeared, in animal experiments, to be the most potent derivative, but it was shown to be less effective than murexine in man. Among the other compounds, imidazolebutyrylcholine and imidazolepropoxycholine appeared to be worthy of particular consideration. The relation between the chemical structure of the murexine-like substances studied and their pharmacological effects is discussed.


Haemoglobinuria caused by propylene glycol in sheep. HAEMOGLOBINURIA OCCURRED IN SHEEP ANAESTHETIZED BY AN INTRAVENOUS INJECTION OF PENTOBARBITONE SODIUM CONTAINING PROPYLENE GLYCOL: an equivalent dose failed to cause haemoglobinuria in rabbits. Intravenous injection of an aqueous solution of 20% propylene glycol caused haemoglobinaemia and haemoglobinuria in sheep. Neither distilled water nor 20% glycerol in water administered under identical conditions produced these effects.Haemoglobinuria occurred on some occasions when an aqueous 20% solution of propylene glycol was administered to sheep after an injection of saline: it never occurred when a solution of 20% propylene glycol prepared with physiological saline was injected. It is suggested that saline may protect against the haemolytic action of propylene glycol in sheep and that propylene glycol should be avoided as a menstruum for pharmaceutical preparations to be used for injection into the blood stream of these animals.


The release of adrenaline and noradrenaline from the adrenal medulla of the cat during splanchnic stimulation. Cats were anaesthetized with chloralose, eviscerated and the right adrenal gland was removed. The venous outflow from the left adrenal gland was collected during 10 five-minute periods of stimulation of the left splanchnic nerve. The amounts of adrenaline and noradrenaline in the venous outflow and in the stimulated and unstimulated glands were determined by a fluorimetric method. In eight experiments a mean of 50.5 mug. of total catechol amine was recovered from the effluent blood. The mean difference in amine content between the stimulated and unstimulated glands was 50 mug., representing a loss of 29% from the stimulated gland. The proportions of the two amines in the effluent blood were very similar to those found in the gland. The results provide no evidence for an increase in the rate of synthesis of catechol amines during splanchnic stimulation.


Protection against systemic poisoning by mustard gas, di(2-chloroethyl) sulphide, by sodium thiosulphate and thiocit in the albino rat. The lethal effects of mustard gas, di(2-chloroethyl) sulphide, in the albino rat have been counteracted by Thiocit, a mixture of sodium thiosulphate and trisodium citrate in the ratio 10:1, administered intraperitoneally in a dose of 2.75 g./kg. Thiocit afforded complete protection against greater than the median lethal dose of mustard gas whether given 10 min. before or 10 min. after mustard gas and raised the LD50 of mustard gas by approximately three times. The protection appeared whether the total dose of Thiocit was given in one injection or serially over 30 min. The effective doses of sodium thiosulphate and of Thiocit in rats were of the order of 3.0 g./kg. Sodium thiosulphate alone and Thiocit have been administered in single doses by slow infusion, by stomach tube and in drinking water. Both have shown activity by all routes of administration, but activity was greatest by intraperitoneal injection. The use of Thiocit in conjunction with mustard gas therapy is suggested.


The effect of some oximes in sarin poisoning. The effects of monoisonitrosoacetone (MINA), diacetylmonoxime (DAM) and pyridine-2-aldoxime methiodide (P2AM) upon the cholinesterase of sarin poisoned rats have been studied. Monoisonitrosoacetone and diacetylmonoxime given before sarin protected blood and brain cholinesterase from inhibition. Monoisonitrosoacetone given after the appearance of signs of poisoning caused a rapid reactivation of brain cholinesterase. Diacetylmonoxime, at an equimolar dose, produced only a slight increase in enzyme activity, and pyridine-2-aldoxime methiodide, the best reactivator in vitro, reactivated blood but not brain cholinesterase. There is a relationship between protection and reactivation of brain cholinesterase and prevention and alleviation of signs of poisoning.


Antiviral action of derivatives of omega-aminoacetophenone. Numerous structural analogues of 3-amino-4-hydroxy-omega-methylaminoacetophenone were tested for their effect on the multiplication of influenza virus (FM(1) strain) in embryonated eggs, infected via the allantoic cavity. Antiviral activity was found in omega-aminoacetophenones containing an amino and hydroxyl group in the aromatic nucleus in the ortho or para positions to each other. The most powerful antiviral activity was found in the series of omega-alkylamino-5-amino-2:4-dihydroxyacetophenones. Derivatives of acetophenone with other substituents in the aromatic nucleus or in the aliphatic chain were without activity. In vitro, several analogues inactive in the egg test, as well as those which were active, exerted a virucidal and to a lesser extent a haemagglutinin-destroying action. Antiviral action in the allantoic test could not be prevented or inhibited by simultaneous administration of reducing substances, or of some amino-acids or vitamins. No inhibition of virus multiplication occurred in embryonated eggs infected via the yolk sac, or in mice infected intranasally with FM(1) virus. The activity in the allantoic test could be explained by the virucidal action of the compounds on the virus present in the allantoic fluid. No satisfactory interpretation of the empirical relationship between chemical structure and antiviral activity could be found.


The uptake of adrenaline and noradrenaline by blood platelets of the pig. Pig platelets contained 0.2 to 2.6 ng. adrenaline/10(8) platelets (4 experiments). Noradrenaline was not detected in them. When platelet-rich plasma was incubated at 37 degrees with 1 or 10mug. of added catechol amine/ml., the platelets continued to accumulate adrenaline for at least 120 min.; only about one-third as much noradrenaline as adrenaline was taken up. The concentrations of adrenaline taken up by different platelet samples at the end of incubation for 90 min. were proportional to the concentration of adenosine triphosphate in the platelets.


A depressant effect of acetylcholine on the idio-ventricular pacemaker of the isolated perfused rabbit heart. In Langendorff preparations of the isolated rabbit heart, excision of the atria and severance of the atrio-ventricular bundle resulted in the onset of idio-ventricular rhythm at a rate much below the original sino-atrial rate. The mean decrease in rate in twelve experiments was 61%. Acetylcholine perfusion decreased the idio-ventricular rate still further. Physostigmine augmented this effect while atropine prevented or abolished it. Similar results were obtained with a rat heart. The results indicate that a cholinergic receptor mechanism is present at pacemaker sites in mammalian ventricles. However, when rabbit ventricles, beating under atrio-ventricular nodal rhythm or idio-ventricular rhythm, were cooled to the point of cardiac arrest, acetylcholine failed to cause reappearance of the cardiac beat.


The relative potencies of some substituted salicylic acids as metabolic stimulants in the intact rat. The effects of eighteen substituted benzoic acids on the rate of oxygen consumption have been studied in rats. 2:3-Dihydroxybenzoic acid, phthalic acid and 6-methylsalicylic acid were, at the doses used, inactive; m- and p-hydroxybenzoic acid, 2:4-, 2:5-, 2:6-, 3:4-, and 3:5-dihydroxybenzoic acid, o-aminobenzoic acid, salicyluric acid, salicylamide and 5-aminosalicylic acid decreased the rate of oxygen consumption. Only salicylic acid and o-, m- and p-cresotic acid (3-, 4- and 5-methylsalicylic acid respectively) increased the rate of oxygen consumption. Molar potency ratios of the cresotic acids as metabolic stimulants relative to salicylic acid were determined; o-cresotic acid was the most powerful with a ratio of 2.61, m- and pcresotic acid had values of 1.78 and 1.89 respectively. Two possible explanations of the higher potencies of the cresotic acids were considered. No difference in the primary action of the drug was established by determining the effect on rate of oxygen consumption of a mixture of o-cresotic and salicylic acids. An alternative possibility was that the rates of detoxication and excretion of the cresotic acids differed among themselves and from salicylic acid. No such differences were found.


Derivatives of 3:4-xylidine and related compounds as inhibitors of influenza virus: relationships between chemical structure and biological activity. A series of compounds, based primarily on 3:4-xylidine, was examined for inhibitory activity towards the growth of influenza virus in tissue culture. Marked dependence of inhibitory activity upon chemical structure was observed particularly when the 3:4-xylyl group was replaced by other simple aryl radicals. N-(2-Piperidinoethyl)-3:4-xylidine dihydrochloride, a typical compound combining high intrinsic inhibitory activity with no obvious toxicity towards the host tissues, did not inactivate the virus directly before its adsorption, did not interfere with adsorption of virus by the tissues, and did not inhibit the release of freshly synthesized virus by the tissues, but specifically depressed the synthesis of viral haemagglutinin to a greater extent than it depressed the synthesis of complement-fixing soluble antigen. The inhibition of growth of influenza virus caused by this compound in tissue culture was reversed by appropriate addition of 4:5-dimethyl-o-phenylenediamine, but not apparently by riboflavin or by vitamin B(12). The action of this substance, and, by inference, of related compounds, in inhibiting viral synthesis may be the result of depressed cytoplasmic protein synthesis.


The curative power of 4-(2:6-diaminopyrimidin-4-ylamino) phenylarsine oxide (compound 12,065) in infections of Trypanosoma rhodesiense in laboratory animals. The toxicity to laboratory animals of 4-(2:6-diaminopyrimidin-4-ylamino)phenylarsine oxide (compound 12,065), and its ability to cure laboratory infections of Trypanosoma rhodesiense were investigated. The intramuscular LD50 to mice was 22 mg./kg.; rats were more susceptible. Monkeys tolerated two daily doses of 6 mg./kg., but not two daily doses of 10 mg./kg. The intramuscular CD50 to mice was about 6 mg./kg. with two strains of T. rhodesiense recently isolated from human patients, and 2 mg./kg. with a strain of T. rhodesiense which had been maintained by cyclical transmission through tsetse flies in the laboratory for about 17 months. These results are compared with those reported by Ainley and Davey (1958) for a strain of T. rhodesiense which had been maintained in the laboratory by cyclical transmission for about 12 years and then by syringe transmission for about 10 years. The syringe-transmitted strain was at least 20 times more susceptible to the drug than the recently isolated strains. The potencies of compound 12,065 and melarsen oxide/BAL in curing T. rhodesiense infections in mice were compared: the CD50 for compound 12,065 was 6.5 mg./kg. and for melarsen oxide/BAL was 3.7 mg./kg. The ratios LD50/CD50 for the drugs were about 4 and 6 respectively.


Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. In isolated guinea-pig intestine 5-hydroxytryptamine increased the longitudinal muscle contractions in response to acetylcholine while the ganglionic action of nicotine was first facilitated and then blocked. Phenyldiguanide, veratrine, veratridine and protoveratrine, like 5-hydroxytryptamine, depressed the response to nicotine, leaving that to acetylcholine unaffected.The sensory stimulants, like 5-hydroxytryptamine, facilitated the peristaltic reflex when applied to the mucosa, and abolished it when applied to the serosa. Preceding the block, the initial effect of low concentrations of 5-hydroxytryptamine applied to the serosa was a short stimulation of peristalsis.Concentrations of 5-hydroxytryptamine which had an approximately equal stimulant action (mucosal 1 to 4 x 10(-6), serosal 2 to 8 x 10(-8)) were tested when various parts of the reflex arc were blocked. During block by procaine introduced into the lumen, mucosal application of 5-hydroxytryptamine re-established peristalsis, but serosal application of 5-hydroxytryptamine had no effect. During block by hexamethonium or atropine present in the bath, 5-hydroxytryptamine restored peristalsis more effectively by serosal application than by mucosal application. During block by serosal application of 5-hydroxytryptamine, morphine, phenoxybenzamine or dihydroergotamine, mucosal application of 5-hydroxytryptamine restored the peristaltic reflex while serosal application had no effect. During block by 2-bromo-lysergic acid diethylamide or lysergic acid diethylamide acting from the serosal surface, 5-hydroxytryptamine had no effect whether acting on the mucosal or on the serosal surface.It is concluded that 5-hydroxytryptamine facilitates the peristaltic reflex at two sites: when introduced into the lumen it stimulates mucosal sensory receptors; when acting from the serosal surface it sensitizes the muscle to the transmitter acetylcholine. There is also a transient stimulant action on the ganglia which is soon followed by inhibition; this indicates that 5-hydroxytryptamine applied to the serosa abolishes peristalsis by ganglion block.


Chemotherapeutic screening of compounds against Theileria annulata in tissue culture. Theileria annulata has been grown in tissue culture and these cultures have been used for screening compounds for chemotherapeutic activity against this parasite. The method described is simple and convenient for testing many compounds in a short time. Forty compounds, including antimalarials, trypanocides, and antibiotics, have been examined, but none has been found to be active.


The action of sympathomimetic amines on heart rate in relation to the effect of reserpine. When the heart-lung preparation is made from a dog treated with reserpine, catechol amines such as noradrenaline and isoprenaline have a greater effect on the rate of the heart than they have in a preparation from a normal dog. Other sympathomimetic amines such as tyramine and ephedrine, on the other hand, are found to have lost their action. Since treatment with reserpine has been shown to cause the store of noradrenaline in the heart to disappear, and the infusion of noradrenaline into the preparation made from a reserpine-treated animal restores the action of tyramine, it is concluded that substances like tyramine and ephedrine normally act by liberating noradrenaline from the store, and do not act directly. Cocaine, like reserpine, increases the effect of noradrenaline and decreases the effect of tyramine on the heart rate; it appears to block the release of noradrenaline from the store in the heart.


Effect of inhibitors of choline acetylation on acetylcholine output and motility in response to anticholinesterases and to distension of the lumen of isolated guinea-pig ileum. Some pharmacological effects of acyl-aryl compounds, which inhibit the enzymatic acetylation of choline, have been studied on the isolated guinea-pig ileum. Diphenylylbutylacetic acid (M.G. 1763) greatly reduced the output of acetylcholine from intestine. The intestinal contractions produced by anticholinesterase drugs were inhibited, while the response to acetylcholine itself was little affected. The contraction of longitudinal muscle elicited by raising intra-luminal pressure was also decreased, while the emptying phase of the peristaltic reflex was scarcely affected. There was a correlation between inhibitory activity and chemical structure.


The depressor action of dopamine and adrenaline. Dopamine is a pressor agent in the spinal cat, but causes a fall of blood pressure in the guinea-pig and rabbit under urethane anaesthesia. When guinea-pigs and rabbits are injected with reserpine, which depletes the vessel walls of noradrenaline, dopamine then becomes pressor. If an intravenous infusion of noradrenaline is given the depressor action returns. An intravenous infusion of vasopressin does not have this effect.A strip of rabbit aorta is caused to contract by noradrenaline and by dopamine, but if dopamine is added at the height of a noradrenaline contraction it causes relaxation.Adrenaline causes a fall of blood pressure in the cat under ether with vagi cut. However, in a reserpine-treated cat its action is pressor. The depressor action is restored during an infusion of noradrenaline. Noradrenaline has thus been shown to cause a vasomotor reversal of dopamine and of adrenaline.


The peripheral action of hexamethonium and of pentolinium. The influence of hexamethonium and pentolinium on the responses of certain peripheral effector cells to adrenaline, noradrenaline or postganglionic stimulation was studied in the cat. The actions of adrenaline and noradrenaline on the blood vessels of a limb and of adrenaline and postganglionic stimulation on the nictitating membrane were increased after the administration of hexamethonium and pentolinium. This effect was considered to be due to sensitization of the peripheral effector cells. The possible significance of these findings is discussed.


Effects of drugs which depress the peripheral nervous system on the reticular activating system of the cat. Some drugs with depressant properties on the peripheral nervous system have been examined for depressant effects on the reticular activating system of the cat. Large doses of nicotine, or of the anti-nicotinic agents dihydro-beta-erythroidine and mecamylamine, failed to depress the reticular activating system; non-quaternary drugs with anti-muscarinic properties, such as atropine and hyoscine, depressed it readily. Hyoscine was the most potent depressant tested and its effects could be antagonized by physostigmine. In contradistinction, depression of the reticular activating system with pentobarbitone was not antagonized by physostigmine. Lignocaine was a weak depressant of the reticular activating system, and the possibility that this might be due to a central anti-muscarinic action is discussed. Adrenergic blocking drugs, such as dihydroergotamine, phenoxybenzamine or choline 2:6-xylyl ether, did not appear to depress the reticular activating system: the significance of this is discussed. It was concluded that the hypothetical cholinergic transmitter, acting somewhere within the reticular activating system, displayed actions analogous to the muscarinic, and not to the nicotinic, actions of acetylcholine.


A microbath.

A microbath. A microbath, with a volume of less than 50 cubic millimetres, for testing the effects of drugs on small pieces of smooth muscle, is described. Drugs are applied automatically in any desired order and the record of their effects is amplified electrically. In this apparatus the response of small pieces of rat uterus to drugs is apt to be nearly all-or-none. Contractions of the muscle from a single ring of guinea-pig trachea were recorded. A fall of pH was found to reduce the effect of 5-hydroxytryptamine on this muscle while leaving the effects of tryptamine and acetylcholine unchanged.


The difference in the metabolism of injected [14C]histamine in male and female rats. [(14)C]Histamine was injected subcutaneously in rats. The urine was collected for 24 hr. and analysed for [(14)C]histamine and its various metabolites. It was found that male rats excreted less unchanged [(14)C]histamine than female ones, the difference between the sexes existing also when the animals were treated with aminoguanidine. The cause of the sexual difference appeared to be that the male rats had a larger capacity to methylate histamine.


The pharmacological actions of pempidine and its ethyl homologue. Pempidine, and other highly active ganglion blocking agents of the polyalkylpiperidine series, were developed from tertiary alkylamines, themselves weakly active, on the hypothesis that high activity was conferred by the presence in the molecule of a sterically hindered secondary or tertiary nitrogen atom. Pempidine and its N-ethyl homologue (26539) resembled mecamylamine qualitatively. All three drugs blocked sympathetic and parasympathetic ganglia; this action was slow in onset and protracted. They blocked neuromuscular transmission, but only about one hundredth as powerfully as ganglionic transmission. They caused a fall in amplitude and rate of the isolated heart, and reduced coronary flow. They had local anaesthetic properties in one of four tests used. They caused tremor. All were well absorbed when administered orally. Pempidine was about twice as active as mecamylamine on ganglia, but only about one half to one quarter as toxic as judged by death, growth, induction of tremor, or cardiotoxicity. Compound 26539 was also quantitatively superior to mecamylamine in respect of these safety margins, but unlike pempidine or mecamylamine damaged the pituitary gland and testis when administered daily for several months. The mode of action of the three drugs is discussed: the results give tentative support for the hypothesis that their action is intracellular.


Recent advances in antibiotic therapy.

Recent advances in antibiotic therapy.


The neuromuscular blocking action of benzoquinonium chloride in the cat and in the hen. Benzoquinonium (Mytolon) has been shown to produce a curare-like rather than a decamethonium-like paralysis of neuromuscular transmission in the tibialis anterior and soleus muscle of cats and the gastrocnemius muscle of hens. In the cat, but not in the hen, benzoquinonium had an additional action in preventing both the twitch potentiating action and the anti-curare action of edrophonium, neostigmine, eserine, and tetraethyl pyrophosphate. Paralysis produced by benzoquinonium was antagonized by injected acetylcholine and by acetylcholine liberated by tetanic stimulation of the motor nerve but, in the cat, anticholinesterases were without effect even when they were first administered in circumstances in which acetylcholine accumulation might be expected to occur. These findings suggested that inhibition of cholinesterase played little part in the skeletal muscle effects of the anticholinesterases studied. Although anticholinesterases did not antagonize benzoquinonium paralysis in the cat, they nevertheless potentiated the antagonistic action of injected acetylcholine.


Spontaneous cure of popliteal aneurysm of syphilitic aetiology.


Donovanosis of the anus in the male; an epidemiological consideration.


Chronic benign circumscribed plasma cell balano-posthitis.


Results of the treatment of gonorrhoea in the Birmingham Clinic.


Syphilitic foetus after prenatal penicillin therapy.


Effects of penicillin, streptomycin, and tetracycline on N. gonorrhoeae isolated in 1944 and in 1957.


Lyophilized survival medium for the T. pallidum immobilization test.


Sensitivity of the Treponema pallidum immobilization (TPI) test; a function of the number of spirochaetes in the antigen.


Diagnosis of chronic prostatitis.

Diagnosis of chronic prostatitis.


Incidence of chronic genital infection in male patients with uveitis; a preliminary report.


Smallpox as a cause of false positive reactions in the Kahn test.


The diagnosis and treatment of major injuries.


Planning for head injuries.

Planning for head injuries.


The cardiac murmur in relation to symptoms in the newborn.


Interphalangeal joint infections.

Interphalangeal joint infections.


Sympathectomy for hypertension; follow-up of 212 patients.


Menstruation and acute psychiatric illnesses.


Natural history of the psychoneuroses.

Natural history of the psychoneuroses.


Atony of the female bladder; report of four cases.


Treatment of chronic non-specific diarrhoea; a clinical comparison.


A CIVIL servant on G.P.s.

A CIVIL servant on G.P.s.


Dequalinium in myasthenia gravis.

Dequalinium in myasthenia gravis.


CHRONIC bronchitis.

CHRONIC bronchitis.


DISAPPEARING bone disease.

DISAPPEARING bone disease.


RELEASE bindings on skis.

RELEASE bindings on skis.


PEPTIC ulcer in infancy and childhood.

PEPTIC ulcer in infancy and childhood.


CINERADIOGRAPHY in diagnosis.

CINERADIOGRAPHY in diagnosis.


SHOCKS for pain.

SHOCKS for pain.


Drug treatment of pneumonia in adults.

Drug treatment of pneumonia in adults.


J. D. WARDALE.

J. D. WARDALE.


R. T. MARTIN.

R. T. MARTIN.


R. BERTRAM BLAIR.

R. BERTRAM BLAIR.


Diabetes among Natal Indians.

Diabetes among Natal Indians.


Carbon monoxide hazard in Antarctica.

Carbon monoxide hazard in Antarctica.


Sleep and wakefulness at high altitudes.


Effect of altitude on basal palmar sweating.


The problem of unilateral amblyopia; a preliminary study of 10,000 National Health patients.


A review of 300 patients with haematemesis or melaena.


Relief of post-operative pain.

Relief of post-operative pain.


Acetazolamide therapy with renal complications.


Acute dystonic reaction to perphenazine.


STAPHYLOCOCCAL infections in hospitals.

STAPHYLOCOCCAL infections in hospitals.


DIABETES in the tropics.

DIABETES in the tropics.


A CASE of many lesions, demonstrated at the Postgraduate Medical School of London.


Leishmaniasis among chewing-gum collectors.


Drug treatment of infants and children suffering from pneumonia.


J. C. GREGORY.

J. C. GREGORY.


The anatomy of malaise.

The anatomy of malaise.


Faults in the diagnosis and management of cardiac pain.


The thyroid and the heart.

The thyroid and the heart.


Oral methyltestosterone and jaundice.

Oral methyltestosterone and jaundice.


Sarcoidosis of the nervous system.

Sarcoidosis of the nervous system.


Chronic bronchitis in industry; an account of a trial of H. influenzae vaccine.


Perineal carriage of Staph. aureus.

Perineal carriage of Staph. aureus.


Effects of aminophylline, nikethamide, and sodium salicylate in respiratory failure.


Resection for pulmonary tuberculosis.

Resection for pulmonary tuberculosis.


Indian childhood cirrhosis.

Indian childhood cirrhosis.


Quinidine poisoning as a cause of generalized muscle weakness.


Thyroid enlargement in schoolchildren of North Oxfordshire.


Allergic primary pulmonary aspergillosis and Schonlein-Henoch purpura.


FUTURE of the tuberculosis service.

FUTURE of the tuberculosis service.


IMPROVING antibiotic performance.

IMPROVING antibiotic performance.


REAPPRAISAL of thymectomy.

REAPPRAISAL of thymectomy.


Cough mixtures.

Cough mixtures.


Why admit to a mental hospital.

Why admit to a mental hospital.


P. G. DOYNE.

P. G. DOYNE.


Z. MENNELL.

Z. MENNELL.


ANAESTHETIST charged with manslaughter; inhalation of anaesthetic alleged.


Laboratory contributions to the tobacco-cancer problem.


Lung cancer mortality and the length of cigarette ends; an international comparison.


Tobacco smoking, respiratory symptoms, and ventilatory capacity; studies in random samples of the population.


The common bile duct after cholecystectomy.


New technique with hydroxydione; experiences with presuren.


Urinary glucuronic acid excretion in liver disease and the effect of a salicylamide load.


Triac stosstherapy in sporadic goitrous cretinism.


The adrenal cortex and winter sports, with a note on other exercise.


Obstruction of respiratory tract in the flexed foetus; a preliminary communication.


A case of aspergillosis treated with nystatin.


ASPIRIN plain and buffered.

ASPIRIN plain and buffered.


PREVENTING recurrences of rheumatic fever.


Drugs in the treatment of syphilis. I.

Drugs in the treatment of syphilis. I.


Out-patient adult psychiatric clinics.

Out-patient adult psychiatric clinics.


SIR MATTHEW FELL.

SIR MATTHEW FELL.


ANAESTHETIST committed for trial.

ANAESTHETIST committed for trial.


Cortisone and corticotrophin in ulcerative colitis.


Fall of blood pressure after a noradrenaline infusion and its treatment by pressor agents.


Clinical experience with selective inhibition of adrenal function.


Noradrenaline-secreting neuroblastomata.


Respiratory difficulties at birth.

Respiratory difficulties at birth.


Social patterns of road accidents to children; some characteristics of vulnerable families.


Effects of oxytocin on the response to suxamethonium.


Acute laryngotracheobronchitis; an account of 122 cases studied in the Hospital for Sick Children, Toronto.


Tracheotomy in influenza.

Tracheotomy in influenza.


A case of early yaws.

A case of early yaws.


Long survival in mitral stenosis; a case report.


Influenza studies in general practice in the Glasgow area.


CHILDREN in hospital.

CHILDREN in hospital.


ROAD ACCIDENTS in childhood.

ROAD ACCIDENTS in childhood.


Drugs in the treatment of syphilis. II.

Drugs in the treatment of syphilis. II.


Use of surgical rehabilitation in young delinquents.


R. SESSIONS HODGE.

R. SESSIONS HODGE.


Fee-per-service and the ideal scheme.

Fee-per-service and the ideal scheme.


[Critical investigations of preoperative intestinal disinfection with special reference to neomycin and bacitracin].


The Johns Hopkins Hospital with especial reference to its relations to medical education and the promotion of medical knowledge.


Kartagener's triad: a family study.

Kartagener's triad: a family study.


Clinical manifestations of hemoglobin C disorders.


Acquired tolerance to bacterial endotoxin: the pyrogen augmenting effect of serum.


Experimental thrombocytopenia and platelet agglutination.


Henry E. Sigerist and aspects of medical historiography.


Keeping up with medicine.

Keeping up with medicine.


Some unusual cases of cerebral tuberculosis.


Malaria in Virginia in the early nineteenth century.


Medical History in Minnesota; a symposium: the growth of graduate medical education.


Three hundred years of medicine in New York City.


Toward a historical sociology of medicine: the endeavor of Henry K. Sigerist.


Medical History in Minnesota; a symposium: the Mayo Brothers, makers of history.


Medical history in Minnesota; a symposium: Saint Marys Hospital.


Hippocrates revisited.

Hippocrates revisited.


Cataloging and classification of medical library materials: 1946-1956. Ten years of progress and problems. I. Cataloging.


Card-form publications in medicine and related fields.


The medical libraries in Yugoslavia.

The medical libraries in Yugoslavia.


THE DEDICATION of the new Topeka Veterans Administration Hospital, August 24, 1958.


Some observations on interviewing in a state mental hospital.


Bibiliography of the history of medicine of the United States and Canada; 1957.


A Sunday with mescaline.

A Sunday with mescaline.


Hereditary aspects of disease.

Hereditary aspects of disease.


Preservation of renal function in the paraplegic.


THE DIAGNOSIS and management of endometriosis.


Trends in medical education.

Trends in medical education.


Management of acute renal failure complicating massive trauma.


A clinical evaluation of a new deodorant-antiperspirant deocin in the American tropics.


Unusual syndromes associated with colloid cyst of the third ventricle.


Neuropathic joint disease (Charcot joints).


Jewish law, social prejudice, and autopsy.


Obstetrical case report.

Obstetrical case report.


The use of peganone in uncontrolled seizure patients.


Stability of purified tuberculin in high dilution. The authors have investigated the effect of storage on the potency of 5 TU dilutions (5 TU per 0.1 ml) of the purified tuberculin RT 19-21 (Statens Seruminstitut, Copenhagen).Dilutions stored at 2-4 degrees C, 20 degrees C and 37 degrees C for different periods up to 18 months were compared by intradermal testing. About 900 BCG-vaccinated schoolchildren were given duplicate tests and in addition 500 tests were made in BCG-vaccinated guinea-pigs.The results showed unexpected variability. It appeared that this variability was due to unsystematic variations in potency both between dilutions prepared at different times and between ampoules of the same dilution.Because of this variability only limited conclusions could be drawn. At 2-4 degrees C the effect of storage seemed to be very slight, the potency of the dilutions being reduced by less than 25% after 18 months. At the higher temperatures, the decrease in activity was more rapid. Nevertheless, the dilutions could be stored at room temperature (20 degrees C) for some months without any practically significant loss of potency.