Prognosis in traction lesions of the brachial plexus.


Late results of removing the medial humeral epicondyle for traumatic ulnar neuritis.


The short leg in poliomyelitis.

The short leg in poliomyelitis.


Treatment of paralysis of the flexors of the elbow.


Correction of the outwardly rotated leg from poliomyelitis; preliminary communication.


Congenital short femur; simple femoral hypoplasia.


Osteotomy of the calcaneum for pes cavus.


Dislocation of the upper end of the fibula.


Observations on the ambulant correction of thoracic scoliosis and kyphosis with particular reference to the experimental use of hydrostatic pressure.


Simple dislocation of the superior tibio-fibular joint; report of a case.


Cubo-navicular synostosis; a rare tarsal anomaly.


A & B antigens in human bone tissue.

A & B antigens in human bone tissue.


Osteoid osteoma of vertebrae.

Osteoid osteoma of vertebrae.


Naviculo-cuneiform synostosis.

Naviculo-cuneiform synostosis.


A comparative radiological study of Reiter's disease, rheumatoid arthritis and ankylosing spondylitis.


Lumbo-sacral interbody spinal fusion.

Lumbo-sacral interbody spinal fusion.


Resolving scoliosis.

Resolving scoliosis.


Experimental epiphysial injury and Freiberg's disease.


Internal fixation in the treatment of fractures of the shafts of the radius and ulna in adults; the value of delayed operation in the prevention of non-union.


Transplantation immunity in bone homografting.


Bilateral coraco-clavicular articulations in the Australian aboriginal.


Blood supply of growing rabbit's tibia.

Blood supply of growing rabbit's tibia.


JONATHAN DOBSON; 1907-1958.

JONATHAN DOBSON; 1907-1958.


JAN ZAHRADNICEK; 1882-1958.

JAN ZAHRADNICEK; 1882-1958.


The effect of maternal thyroid function of fetal thyroid function and development.


Studies on the effect of thyrotropin on human thyroid function.


The thyroid-stimulating hormone content of the human hypophysis; a preliminary report.


The effect of iodide on the action of thyrotropin in the hypophysectomized patient.


Effect of desiccated thyroid in lymphocytic (Hashimoto's) thyroiditis.


Struma lymphomatosa (Hashimoto's thyroiditis) and related thyroidal disorders.


Clinical observations on serum globulin thyroxine-binding capacity, using a simplified technique.


Thyroid function in supraventricular tachycardias: turnover of intravenously infused I 131-labeled thyroxine and the red blood cell uptake of I 131-labeled 1-triiodothyronine.


The plasma protein-thyroid hormone complex in man. III. Further studies on the use of the in vitro red blood cell up take of I 131-1-triiodothyronine as a diagnostic test of thyroid function.


The effect of 1-thyroxine on serum lipoprotein and cholesterol concentrations.


Occurrence of thyroid nodules in children following therapy with radioiodine for hyperthyroidism.


Exophthalmic goiter in children.

Exophthalmic goiter in children.


Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity.


Parenchymal findings in thyroidal carcinoma: pathologic study of 256 cases.


Thyroid autoantibodies in the families of cretins.


Effect of norethandrolone on 17-ketosteroid excretion in prostatic cancer patients.


The role of hormones in human behavior. I. Changes in female sexuality after adrenalectomy.


Congenital virilizing adrenal hyperplasia in identical twins.


Determination of progesterone in human blood plasma.


Plasma cortisol levels in man following oral and intravenous administration of cortisol.


Hypoparathyroidism: report of a case successfully treated with intravenous vitamin D2.


Correlation of goiter, deafmutism and mental retardation with serum thyroid hormone levels in noncretinous inhabitants of a severe endemic goiter area in India.


Effect of oral lipiodol on thyroidal I 131 uptake and serum protein-bound iodine concentration.


Hormonal treatment of Hand-Schüller-Christian disease: report on a case with disappearance of the bone lesions.


Failure of insulin to induce a change in rate of growth in a 14-year-old boy with anterior pituitary insufficiency.


Electrophoretic alterations in serum proteins of patients with hirsutism.


Acid mucopolysaccharide in the thyroid gland.


Failure to demonstrate hydrocortisone and aldosterone during pregnancy in Addison's disease.


Unusual plasma 17-ketosteroid pattern in a boy with congenital adrenal hyperplasia and periodic fever.


Adrenal hyperresponsiveness resulting from prolonged corticotropin therapy.


Studies on the renal concentrating mechanism. II. Effect of small acute changes in solute excretion.


Studies on the renal concentrating mechanism. III. Effect of heavy exercise.


Experimental catatonia and psychopharmacology of neuroleptics.


The destruction of glucagon, adrenocorticotropin and somatotropin by human blood plasma.


A new procedure for the administration of carbon dioxide.


The mechanism of potassium excretion in the chicken.


Methacholine reaction indices as prognosticators for insulin coma therapy.


Studies on the biogenesis and metabolism of norepinephrine in patients with pheochromocytoma.


Atropine coma therapy.

Atropine coma therapy.


The nature and mechanism of the hemostatic breakdown in the course of experimental hemorrhagic shock.


Dynamics in a case of obesity.

Dynamics in a case of obesity.


On the mechanism of acidosis in chronic renal disease.


Studies of iodoalbumin metabolism. I. A mathematical approach to the kinetics.


A controlled study of the use of meprobamate in a mental hygiene clinic.


Studies of iodoalbumin metabolism. II. The effects of thyroid hormone.


The characteristics and similarity of primary and secondary peristalis in the esophagus.


Mechanism of intrinsic factor action in everted sacs of rat small intestine.


Experiences in the use of promazine in hospitalized chronic psychotic patients.


The effect of experimentally induced hypervolemia on cardiac function in normal subjects and patients with mitral stenosis.


Some factors affecting indicator dilution curves in the presence and absence of valvular incompetence.


Platelets as a source of serum acid nitrophenylphosphatase.


Microelectrophoresis of blood platelets and the effects of dextran.


Transfer of iron from serum iron-binding protein to human reticulocytes.


Hyperlipemia in early stages of acute glomerular nephritis.


Sodium and water depletion and ammonia formation by the kidneys.


Studies on influenza in the pandemic of 1957-1958. I. An epidemiologic, clinical and serologic investigation of an intrahospital epidemic, with a note on vaccination efficacy.


Studies on influenza in the pandemic of 1957-1958. III. Isolation of influenza A (Asian strain) viruses from influenza patients with pulmonary complications; details of virus isolation and characterization of isolates, with quantitative comparison of isolation methods.


Studies on influenza in the pandemic of 1957-1958. II. Pulmonary complications of influenza.


A comparison of biological and some cultural methods for the primary isolation of Mycobacterium tuberculosis.


The complement fixation test and its application to the diagnosis of rinderpest.


Metabolic changes in cattle near the time of parturition. I. Hepatic fat and alkaline phosphatase activity of liver homogenates.


The blood groups of the pig. VI. Red cell antigens other than the A-O system.


The metabolism of ketone bodies in the ruminant.


The complement-fixing capacity of aqueous extracts of mycobacteria.


The propagation of canine distemper virus in tissue culture.


Infectious gastro-enteritis of pigs. I. The disease in the field.


Arteriosclerosis in certain wild animals dying in captivity.


Chemoprophylaxis against bovine trypanosomiasis. I. Duration of protection from prothidium, and ethidium and R.D. 2902 suraminates, in an area of high tsetse density.


The production in mice of active immunity against Pasteurella haemolytica.


Studies in experimental behavior genetics. I. The heritability of phototaxis in a population of Drosophila melanogaster.


Galvanotropism as an avoidance response.


The relation between habituation and the stability of the following response.


Electrical responses of primate visual system. I. Different layers of macaque lateral geniculate nucleus.


Rewarding and punishing effects from stimulating the same place in the rat's brain.


Satiation effects in self-stimulation of the brain.


Depressive effects of ECS as related to the peak intensity of unidirectional square-wave ECS.


Depression of bar-press responding as related to stimulus parameters of interjected unidirectional square-wave ECS.


The effect of ECS on retention of a discrimination habit in rats subjected to anoxia.


Correlation of skin resistance and potential.


An effect of high- and low-calcium diets on the maze performance of rats.


Conceptual discrimination in rhesus monkeys.


Homogeneous and heterogeneous reward of monkeys.


Conditional discrimination and stimulus patterning.


Discrimination-reversal learning in pigeons.


Irrelevant-incentive learning; a repetition and a revision.


Comparison of two methods of investigating the effect of amount of reward on performance.


The effects of drive level on performance and extinction of a learned response in rats and fish.


Secondary reinforcement as affected by reward schedule and the testing situation.


A comparison of some presumed frustrating and secondary-reinforcing operations.


The relative effectiveness of reward and punishment for discrimination learning in children.


The learning of object and pattern discriminations by children.


Learning set in children as a function of intellectual level.


Evidence for a learning theory of specific hunger.


The effects of early avoidance training and rearing conditions upon the sexual behavior of the male rat.


The effect of long confinement on voluntary wheel-running by rats.


Differential maturation of an adrenal response to cold stress in rats manipulated in infancy.


Discrimination learning and interdimensional transfer under conditions of systematically controlled visual experience.


The perception of movement by young chimpanzees and human children.


Visual and visual-motor experience: a replication.


The maintenance of play in young children.


Absolute and relative sucrose preference thresholds for hungry and satiated rats.


The effect of amphetamine on forced drinking in the rat.


The effects of meprobamate, chlorpromazine, pentobarbital, and a placebo on a behavioral task performed under stress conditions.


Adrenocortical hyperfunction with sudden onset of hirsutism.


The response of the mammary gland of the male mouse to progesterone and human mammotrophic substances.


Human urinary gonadotrophins. II. In relation to the menstrual cycle, secondary amenorrhoea and the response to oestrogen.


Steroids and other lipids of pregnant cow's urine.


The effect of steroid hormones on the absorption of antibody by the young rat.


The relationship between urinary excretion of ovarian hormone metabolites and cornification of the vaginal epithelium during the menstrual cycle.


A method for the quantitative determination of gonadotrophins in the urine of non-pregnant human subjects.


The influence of ACTH and cortisol upon skin homografts in the rat.


Effects of oestrogens and ACTH on the adrenals of the guinea-pig compared with those in the rat.


Occurrence of anoestrus in mice caged in groups.


The biosynthesis of thyroxine and 3:5:3'-triiodothyronine in larval and adult toads.


The transport of ova in relation to the dosage of oestrogen in ovariectomized rabbits.


Effects of water deprivation upon the neurosecretory material of the desert rat (Meriones meriones) compared with laboratory rat.


The biological activity of soluble antigen-antibody complexes. II. Physical properties of soluble complexes having skin-irritating activity. Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag(2)Ab), does not have the activity, whereas, Ag(3)Ab(2) and more complicated complexes do. The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented.


The effect of diphtheria toxin on the metabolism of HeLa cells. The effect of diphtheria toxin on certain metabolic processes in growing HeLa cells has been described. It was found that both aerobic respiration and glycolysis are insensitive to toxin action. The incorporation of S(35)-methionine was found to be completely inhibited by toxin prior to the appearance of any visible cell damage. It was also observed that toxin levels above 0.3 Lf per ml. had no further effect on the kinetics of inhibition of methionine uptake. The kinetics of intoxication were studied by adding diphtheria antitoxin to a partially intoxicated culture at various times and measuring the resulting rate of methionine uptake. Low temperatures were found to block intoxication. Using this information, data were obtained suggesting that the initial step in the process of intoxication consists of a rapid adsorption of toxin by the cell. The kinetics of toxin action on protein synthesis were compared with those of cyanide and 2,4-DNP. Diphtheria toxin eliminates completely any methionine uptake remaining after exposure of the cell to either of these respiratory inhibitors. The significance of these results is discussed.


Depletion of reserve protein from extravascular extracellular fluid; C14 labeling of plasma proteins in dogs after plasmapheresis. During protein depletion produced by plasmapheresis and a very low protein diet there is a proportionately greater decrease in extravascular, extracellular fluid protein than in plasma protein. A shift in the normal ratio of protein in these 2 compartments, approximately 1 to 1 in the dog, to over 2 to 1 as a result of depletion indicates an important, labile source of reserve protein for the plasma in the interstitial fluids. This reserve source is limited since a maximum drop of 50 per cent in the total exchangeable pool and of 75 per cent in the extravascular, extracellular protein occurred after both shorter and longer periods of depletion. Under the rigid conditions of these experiments additional plasma protein removal was associated with loss of weight despite adequate caloric intake. Investigation of the status of the interstitial fluid proteins in other conditions associated with disturbed protein metabolism seems warranted.


Plasma protein turnover and tissue exchange; influence of dietary protein and protein depletion. The rate of plasma protein turnover is more rapid in dogs receiving adequate dietary protein than when a diet devoid of protein is fed. Both albumin and combined globulins are involved in this change. The difference in turnover is reflected in a total protein half-life of 4.8 days with protein feeding versus 7.8 days without protein in the diet and in the metabolism of 1.0 and 0.65 gm. per kilogram of body weight per day on the respective diets. Additions of dietary protein from 10 to 30 per cent caused no further increase in the rate of plasma protein turnover. With protein depletion due to plasmapheresis and a very low protein diet there is evidence of reduced protein metabolism as indicated by nitrogen retention as well as a reduction in total plasma protein breakdown and interchange of isotope between plasma and tissue proteins. Following introduction of labeled plasma protein into the circulation the net amount of isotope transferred to tissues has been computed from the difference between total plasma protein breakdown and combined C(14) excretion in urine and expired air. In animals receiving adequate dietary protein, tissue transfer amounts to 70 per cent of the total lost from the plasma proteins each day while the percentage rises to 85 in depleted dogs deprived of protein. In dogs with both plasma and tissue proteins labeled it can be estimated that, under conditions of protein feeding, an amount of C(14) approximately equal to that lost from the plasma must recycle to account for the observed decrease in Apparent plasma protein turnover rate, (t(1/2) of 15 versus 5 days). Without protein in the diet the isotope contribution of the tissues to the maintenance of plasma protein levels must be as great as or greater than that transferred in the opposite direction.


The respiration and cytochrome oxidase activity of rat aorta in experimental hypertension. Oxygen consumption and cytochrome oxidase activity of aortas of rats with experimental hypertension were found to be higher than the corresponding values for aortas of normotensive animals. The higher metabolic activity of aortas of hypertensive animals appeared to be due both to an increase in the proportion of muscle cells to connective tissue fibers and to a higher activity of the intracellular portion of the tissue.


Immunological relationships of a filterable agent causing a leukemia in adult mice. I. The neutralization of infectivity by specific antiserum. The antigenic character of a filterable agent which induces leukemia in adult mice has been investigated. Mice and rabbits injected with filtrate yielded sera which specifically neutralized infectivity of the agent. Normal sera, sera from mice with other neoplasms-including leukemias from which no causative agent has as yet been obtained,-and sera from leukemic human beings contained no such neutralizing antibody. A formalinized vaccine prepared from filtrates of leukemic spleens induced a significant degree of immunity against the agent, approximately 80 per cent of the vaccinated mice being immune on challenge with it.


The cellular transformation of injected colloidal iron complexes into ferritin and hemosiderin in experimental animals; a study with the aid of electron microscopy. As revealed by electron microscopy and electron diffraction, the physical state of ferric hydroxide micelles contained in iron-dextran, saccharated iron oxide, and hydrous ferric oxide ("ferric hydroxide") differs notably from the state of the ferric hydroxide in ferritin or hemosiderin. By virtue of this difference one can trace the intracellular transformation of colloidal iron, administered parenterally, into ferritin and hemosiderin. One hour after intraperitoneal injection of iron-dextran or saccharated iron oxide into mice, characteristic deposits were present in splenic macrophages, in sinusoidal endothelial cells of spleen and liver, and in vascular endothelial cells of various renal capillaries. Four hours after injection, small numbers of ferritin molecules were identifiable about intracellular aggregates of injected iron compounds; and by the 6th day, ferritin was abundant in close proximity to deposits of injected iron compounds. The latter were frequently situated in cytoplasmic vesicles delimited by single membranes. These vesicles were most frequently found in tissue obtained during the first 6 days after injection; and in certain of the vesicles ferritin molecules surrounded closely packed aggregates of injected material. Much unchanged ferric hydroxide was still present in macrophages and vascular endothelial cells 3 to 4 weeks after injection. While electron microscopy left no doubt about the identity of injected ferric hydroxide on the one hand, and of ferritin or hemosiderin on the other, histochemical tests for iron failed in this respect. Precipitation of ferric hydroxide (hydrous ferric oxide) from stabilized colloidal dispersions of iron-dextran was brought about in vitro by incubation with minced mouse tissue (e.g. liver), but not by incubation with mouse serum or blood. Subcutaneous injections of hydrous gel of ferric oxide into mice initially produced localized extracellular precipitates. Most of the material was still extracellular 16 days after injection, though part of it was phagocytized by macrophages near the site of injection; but apparently none reached the spleen in unaltered form. Five days after injection and thereafter, much ferritin was present in macrophages about the site of injection and in the spleen. The findings show that iron preparations widely used in therapy can be identified within cells, and that their intracellular disposition and fate can be followed at the molecular level. Considered in the light of previous work, they indicate that the characteristic structure of the ferric hydroxide micelles in molecules of ferritin is specific, and develops during the union of apoferritin with ferric hydroxide. Apparently this union does not depend upon specific cell components.


Participation of bicarbonate in RNA and protein synthesis as indicated by virus propagation in human cells. The propagation of a strain of Coxsackie virus, group B type 1, in human cell cultures depleted of bicarbonate has been studied. Under the described experimental conditions, bicarbonate depletion suppresses the propagation of this virus. This suppressive effect may be reversed by the addition of the following compounds to the bicarbonate-depleted cultures: (a) bicarbonate; (b) adenosine, guanosine, cytidine, and uridine; (c) adenylic, guanylic, cytidylic, and uridylic acids; (d) enzymatically degraded RNA prepared from yeasts or human embryo, or (e) RNA. The following compounds are unable to reverse the suppressive effect of bicarbonate depletion: (a) adenine, guanine, cytosine, and uracil, with or without ribose; (b) adenine, guanine, cytosine, and thymine; (c) deoxyadenosine, deoxyguanosine, deoxycytidine, and thymidine; (d) deoxyadenylic, deoxyguanylic, deoxycytidylic, and thymidylic acids; (e) enzymatically degraded DNA, or (f) DNA. The same general results as with the Coxsackie virus have been obtained with a strain of poliovirus and vaccinia virus. The failure of bicarbonate depletion to suppress completely the propagation of the poliovirus under the described condition constitutes a major difference. The significance of these findings is discussed.


The relative importance of the capsule and the M-antigen in determining colony form of group A streptococci. Evidence is presented showing that the surface configuration of Group A streptococcal colonies depends largely on whether or not the cocci form a capsule. Strains which form capsules during growth on agar produce mucoid or matt colonies. Strains that do not form capsules during growth on agar produce glossy colonies. Whether or not M antigen is formed by the growing cocci appears to have no direct effect on surface configuration of the colony, although there is an indirect and partial association between M production and the mucoid-matt variant state and between M deficiency and the glossy variant state.


Separation and characterization of human serum chylomicrons. Chylomicrons were separated by low and high speed ultracentrifugation from lipemic sera of human subjects in the absorptive phase. The final chylomicron preparation was free from other serum components and contained a small constant amount of protein, approximately 2 per cent of the chylomicron fraction. Electrophoresis, immunochemical analysis, and absorption experiments identified the protein component as derived from a mixture of beta and alpha(1) serum lipoproteins. Large aliquots of an emulsion of serum freed of chylomicrons and coconut oil were incubated at 37 degrees C. for 2 hours and ultracentrifuged as in the preparation of chylomicrons. The fat particles now showed the presence of minute amounts of beta and alpha(1) serum lipoproteins in almost the same proportion as found in chylomicrons. "Finger prints" of delipidized samples of chylomicrons and particles from serum-coconut oil emulsion gave similar, although not identical patterns. The data on "clearing factor" activity corroborated the finding that serum alpha(1) lipoproteins are contained in chylomicrons and particles from serum-coconut oil emulsion. These two lipide particles, partially delipidized, were both able to activate a "clearing factor" system in vitro, a property exhibited only by intact or partially delipidized alpha(1) serum lipoproteins. Clearing activity was satisfactorily determined by using an emulsion of coconut oil mixed in agar as a substrate to give an opaque gel, in which the diffusing enzyme showed its activity by areas of clearing. The results obtained by this technique were in agreement with those based on fall in optical density and non-esterified fatty acid production. Chemical analysis of serum chylomicrons showed a concentration of cholesterol and phospholipides higher than could be accounted for by the attached beta and alpha(1) serum lipoproteins. On the basis of these results the assumption is made that in the blood stream small amounts of serum lipoproteins, by a process of adsorption, form a complex with the absorbed triglycerides, cholesterol, and phospholipides, to produce chylomicrons.


Study on growth of Rickettsia. V. Penetration of Rickettsia tsutsugamushi into mammalian cells in vitro. A system has been described in which the penetration of Rickettsia tsutsugamushi (Karp strain) into tissue culture cells can be quantitated, and the factors affecting this process studied. The results indicated that rickettsial penetration in vitro depended largely on the viability of the organisms. Certain components of the fluid environment such as the divalent cations and protein were found to be of importance. The temperature dependence of the penetration process was found to vary with the nature of the suspending medium. A number of compounds related to L-glutamic acid enhanced penetration, whereas metabolic inhibitors depressed this process. Aureomycin at concentrations between 50 and 250 microg./ml. inhibited the penetration of rickettsiae while chloramphenicol at similar concentrations was ineffective. The results are discussed in terms of the biological and biochemical properties of this group of agents.


Experimental atherosclerosis and cardiac infarcts in rats. Marked obesity was induced in rats by feeding a high fat, egg yolk-rich diet. The obese rats were hyperlipemic and showed an increased incidence of lipomatous coronary lesions, but did not develop severe atheromatous lesions. Spontaneous vascular lesions of several kinds have been observed in aging rats. Among them, plaques containing a fibrin-like material seem to be conspicuous. However, these lesions differ from the experimentally induced changes, which were more fatty. Atherosclerosis, as it is defined in human pathology, has not been observed to develop spontaneously in rats. Experimental induction of marked hyperlipemia and hypercholesterolemia by feeding a high fat egg yolk-rich diet (supplemented with cholesterol, choleate, and thiouracil), and use of viosterol to cause vascular injury, led to severe atherosclerosis, coronary occlusion, and myocardial infarction. A consideration of all the findings reported here leads to renewed support of the concept that atherosclerosis has a combination of causes (Aschoff, Anitschkow, Page). Of all the etiological factors considered here, elevation of blood lipides and vascular injury are thought to be the most important ones.


The influence of irrelevant information upon complex visual discrimination.


A histologic study of the auto-allergic testis lesion in the guinea pig. The auto-allergic lesion in guinea pigs inoculated with homologous testis plus the Freund adjuvant was investigated histologically. The lesion was found to consist of disseminated foci of perivenous inflammation, lymphocytes and histiocytes predominating in the cellular infiltrate, with invasion of epididymal, rete, and seminiferous tubules and destruction of tubular contents. Guinea pigs up to 800 gm. showed a rapidly progressing diffuse hypo- or aspermatogenesis, which appeared to be secondary to the inflammatory disease. In these animals, the process resolved leaving an atrophic testis with few or no indications of the preceding inflammation and fibrotic scarring only in the rare instances in which actual necrosis of connective tissue elements had occurred. In 1200 gm. animals there was no general hypospermatogenesis and the late findings were limited to foci of aspermatogenesis. This disease then is an experimental auto-allergic orchitis followed by testicular atrophy without scarring. Its morphologic similarity to mumps orchitis and to sterility with "germinal cell aplasia" in man is commented on.


Discrimination in the squirrel monkey as a function of deprivation and problem difficulty.


Effects of instructions on the transfer of a conditioned response.


Additivity of cues and transfer in discrimination of consonant clusters.


Relation of stress and differential position habits to performance in motor learning.


Effect of preliminary trials on rate of conditioning in a simple prediction situation.


The differential effects of word and object stimuli on the learning of paired associates.


Decision making behavior in a two-choice uncertain outcome situation.


Extinction after acquisition under different verbal reinforcement combinations.


Performance in different segments of an instrumental response chain as a function of reinforcement schedule.


Performance decrement at an audio-visual checking task.


Replication report: meaning established by classical conditioning.


Ionic transfer across the isolated frog large intestine. The unidirectional fluxes of sodium, chloride, and of the bicarbonate and CO(2) pair were determined across the isolated large intestine of the bullfrog, Rana catesbiana. The isolated large intestine of the frog is characterized by a mean transmembrane potential of 45 mv., serosal surface positive with respect to mucosal. The unidirectional sodium flux from mucosal to serosal surface was found to be equal to the short-circuit current, thus the net flux was less than the simultaneous short-circuit current. This discrepancy between active sodium transport and short-circuit current can be attributed to the active transport of cation in the same direction as sodium and/or the active transport of anion in the opposite direction. The unidirectional fluxes of chloride and the bicarbonate and CO(2) pair revealed no evidence for active transport of either anion. A quantitative study of chloride fluxes at 45 mv. revealed a flux ratio of 1.8 which is considerably less than a ratio of 6 expected for free passive diffusion. It was concluded that a considerable proportion of the isotopic transfer of chloride could be attributed to "exchange diffusion." Study of the electrical properties of the isolated frog colon reveals that it can be treated as a simple D. C. resistance over the range of -20 to +95 mv.


Early and late post-tetanic potentiation, and post-tetanic block in a monosynaptic reflex pathway. Observations have been made upon the nature of early and late post-tetanic potentiation and upon post-tetanic block of presynaptic collaterals with particular reference to behavior in circumstances of varied duration and frequency of conditioning stimulation. Early potentiation is most conspicuous following brief tetani at high frequency, late potentiation following long tetani, much lower frequencies being all that are needed. The two phenomena thus are distinguishable and separate. Dorsal root electrotonus produced by stimulations of varying duration and frequency is described, and the similarity between behavior of the D.R.IV R. electronic potential and early potentiation demonstrated. It is shown how early potentiation and post-tetanic block are due to the same process (hyperpolarization) at different intensities. The view that the agency for potentiation is associated with augmented presynaptic action due to hyperpolarization is confirmed. A diagram is constructed to indicate the probable temporal courses of early and late potentiation.


An adenosinetriphosphate-activated hemolytic system. II. Utilization of adenosinetriphosphate in the reaction. Failure to demonstrate ATP(1) utilization in an ATP-activated hemolytic system had been previously reported. In the present study ATP utilization is shown to be associated with the hemolytic reaction and also with the ATP-dependent inactivation of the hemolytic factor of the system by crude, washed, human red cell stroma. Using crude stroma, relatively large ATP utilization occurs and continues, but at a decreasing rate, after inactivation of the hemolytic factor is complete. With purified stroma there is very slight uptake of ATP by the stroma in the presence of hemolytic factor and Mg(++). This uptake can only be demonstrated by radioactive ATP. Both C(14)- and P(32)-labelled nucleotide were used for this purpose. In the presence of an excess of stroma the uptake seems to be dependent on the amount of hemolytic factor used. Evidence is given contraindicating the possibility that this uptake is non-specific.


The release and stability of the large subunit of DNA from T2 and T4 bacteriophage. T(2) and T(4) bacteriophage have been exposed to various treatments which are known to release the encapsulated DNA. The unseparated reaction products have been examined by autoradiography. The results indicate the presence of one large subunit of DNA (molecular weight 45 x 10(6)) for each former phage particle. Some smaller subunits of molecular weight 12 x 10(6) have been observed. The large subunit is sensitive to very small amounts of DNAase, and is resistant to mixed proteases and cannot be dispersed by banding in cesium chloride density gradients. The sensitivity to fragmentation by P(32) decay and the increase in this sensitivity following heat treatment are best explained by assuming that the large subunit is a duplex of polynucleotide strands over most of its length. The presence of hypothetical non-DNA interconnections is considered.


Effect of temperature on electrolyte metabolism of isolated frog skin. A study is presented on the effect of temperature on unidirectional active ion transport, resting electrolyte equilibrium (electrolyte composition), and oxygen consumption in isolated frog skin. The aims were twofold: first, to find out whether the rate of active transport can be changed without affecting the Na(+) and K(+) balance of skin itself; second, to arrive at minimal DeltaNa/DeltaO(2) values by correlating quantitatively inhibition of active ion transport with inhibition of O(2) consumption. NaCl transport was maximal at 20 degrees C. At 28 degrees and at temperatures below 20 degrees , rate of NaCl transport was diminished. In many instances NaCl transport was diminished in skins which maintained their normal Na(+) and K(+) content. In several cases, however, neither rate of transport nor resting electrolyte equilibrium was affected; in other cases, both were. O(2) consumption decreased when lowering the temperature over the range from 28 to 10 degrees C. From a plot of log Q(OO2) against 1/T an activation energy of micro 13,700 cal. was calculated, valid for the range from 10 to 20 degrees C. It appeared that micro was smaller for temperatures above 20 degrees C. Working between 10 and 20 degrees , it was found that, on the average, 4 to 5 equivalents of Na(+) were transported for one mole of O(2) consumed in skins with undisturbed resting electrolyte equilibrium.


A study of inotropic mechanisms in the papillary muscle preparation. The length-tension diagram, the force-velocity relation, the characteristics of the series elasticity, and the duration of the active state have been studied on the papillary muscle preparation of the cat heart, and on other examples of cardiac muscle. Positive inotropic changes such as the staircase phenomenon and post-extrasystolic potentiation occur without lengthening, but frequently with shortening, of the duration of the active state. They are accompanied by an increased velocity of contraction, and may be caused either by an intensification of the active state or by an alteration of the force-velocity characteristics of the contractile component. The changes in the force-velocity relation point to an adaptation of the velocity-efficiency relation in dependence on the frequency of contraction.


The amino acid composition of crystalline pepsin. The amino acid composition of twice recrystallized pepsin (Worthington Biochemical Corporation) has been determined chromatographically on columns of Amberlite IR 120 resin. The results of the analyses obtained on four different preparations indicate a close agreement in their amino acid composition. Pepsin is unique in that it has a great predominance of acidic amino acids over basic ones. Moreover, all the preparations contain a small and constant amount of hydroxyproline, corresponding to about 0.1 residue per molecule.


Ultraviolet difference spectra of pepsin. A shift of pH of pepsin solutions from 4.6 to 1.0 gives rise to spectral displacements in the ultraviolet. If represented as difference spectra three peaks with maxima at 2770, 2850, and 2930 Angströms are present which can be attributed to the tyrosine and tryptophan residues in the protein. On mild autolysis of pepsin at pH 2.0 the absorbancy in the ultraviolet further decreases. Although some of these effects can be ascribed to the occurrence of hydrogen bonding between the aromatic residues and a carboxylate ion, those observed on autolysis are caused by charge effects of newly formed polar groups in the vicinity of a chromophore. No direct relation between the optical properties described here and enzymic activity of pepsin has been observed.


Protein concentration in normal mouse lymphocytes, thymocytes, and mouse and human leukemic cells as measured by interference microscopy. The apparent protein content of a single spherical lymphocyte or a similar cell, as well as its diameter, can be measured by a modified and stabilized AO-Baker interference microscope which is either fitted with an AO half-shade eyepiece or connected to a photomultiplier. This paper gives results for the apparent protein content and the diameter of normal mouse lymphocytes and thymocytes; these do not differ significantly from each other. It also gives values for the apparent protein concentration and the diameter of the lymphocytes of mice of the same strain which have developed leukemia or lymphoma; these values are significantly different from those of normal mice. Related data are given for the apparent protein content and for the diameter of normal human lymphocytes and the white cells found in myeloblastic leukemia and in stem cell leukemia in man; here the values differ significantly from those of the normal human lymphocyte. The rule seems to be that the abnormal white cells become more watery and larger as the disease advances.


In vitro studies of p32 uptake in mouse liver mitochondria. Isolated mouse liver mitochondria were incubated in two types of P(32)-labelled sucrose-phosphate buffers. The first contained no added ATP or oxidizable substrate. The second contained added ATP. Samples were taken at specified times, up to 60 minutes, and analyses were made of the mitochondrial TCA-soluble inorganic P(32) and the total mitochondrial residue P(31) and P(32). The results of the analyses showed that when the phosphorus inhibition index (the ratio of the amount of incubation inorganic phosphorus to the square of the amount of tyrosine in the mitochondria) was high, inorganic P(32) uptake was low and vice versa. In accordance with established data, increased P(32) uptake was obtained when ATP was added. ATP was found to stabilize the turnover of TCA-insoluble residue phosphorus as well as to maintain the TCA-soluble orthophosphate pool. These results support findings regarding the inhibitory and controlling effects of incubation medium phosphate in the regulation of inorganic phosphorus uptake.


The effect of ultraviolet light on the sodium and potassium composition of resting yeast cells. The Na(+) and K(+) content of non-metabolizing yeast cells was determined before and after monochromatic ultraviolet (UV) irradiation. UV facilitated the uptake of Na(+) into and the loss of K(+) from the cells (net ion flux); the effect is greatest for the shortest wavelength employed (239 mmicro) and is partly dependent upon the presence of oxygen. The UV effect on net ion flux persists for at least 90 minutes during which tests were made and it occurs following dosages which are without measurable effect on colony formation. The UV effect on net ion flux is decreased by acidity and promoted by alkalinity. Addition of calcium ions in sufficient amount prevents the usual net ion flux changes observed in irradiated yeast. Increase in concentration gradient between the inside and the outside of the cell increases the net ion flux of irradiated yeast, Na(+) uptake leading K(+) loss in all cases. UV appears to act by disorganizing the constituents of the cell surface, permitting K(+) to leave the cell in exchange for Na(+). At low intensities of UV this ionic exchange approaches equivalence, but at higher intensities more Na(+) is taken up than K(+) is lost. Some evidence suggests that the Na(+) in excess over that exchanged for K(+) is adsorbed to charged groups produced by the photochemical effect of UV on the cell surface.


The function of the proximal synapses of the squid stellate ganglion. In the oxygenated excised squid (Loligo pealii) stellate ganglion preparation one can produce excitation of the stellar giant axons by stimulating the second largest (accessory fiber, Young, 1939) or other smaller preganglionic giant axons. Impulse transmission is believed to occur at the proximal synapses of the stellar giant axons rather than the distal (giant) synapses which are excited by the largest giant preaxon. Proximal synaptic transmission is more readily depressed by hypoxia and can be fatigued independently of, and with fewer impulses than, the giant synapses. Intracellular recording from the last stellar axon at its inflection in the ganglion reveals both proximal and distal excitatory postsynaptic potentials EPSP's). The synaptic delay, temporal form of the EPSP, and depolarization for spike initiation were similar for both synapses. If the proximal EPSP occurs shortly after excitation by the giant synapse it reduces the undershoot and adds to the falling phase of the spike. If it occurs later it can produce a second spike. Parallel results were obtained when the proximal EPSP's arrived earlier than the EPSP of the giant synapse. In fatigued preparations it was possible to sum distal and proximal or two proximal EPSP's and achieve spike excitation.


The influence of the medium dielectric strength upon trypsin kinetics. The use of aqueous alkali for the titration of esterolytic activity when the esters are dissolved in alcoholic solutions, results in an error due to changes in the ionization of the buffer. This is corrected by titrating with alkali in the same solvent as the substrate. Alcohols and other substances which change the dielectric strength of water modify the rate of hydrolysis of BAEE(1) and TSAME by trypsin to an extent proportionate to their effect on the dielectric strength. The reaction rate increases with diminished dielectric strength and vice versa. At low concentrations of substance there seems to be no specific effect other than that derived of the variation in dielectric strength. At higher concentrations, the enzyme might be denatured. In addition, it is probable that specific effects of each substance might intervene. The Coulombic and thermic energies of activation were calculated for the two esters in various solvents. The plot of the logarithm of rate constant vs. reciprocal of dielectric constant yields a straight line with positive slope. This behavior is similar to that of a non-enzymatic positive ion-dipole reaction. Trypsin reacts like a positive ion. The possible influence of the dielectric strength on the regulation of the equilibria involved in the interconversion of the various forms of trypsin in solution (active, inactive, denatured) is discussed.


An enzymatic ion exchange model for active sodium transport. An enzymatic ion exchange model for active sodium transport is described. Kinetic equations relating net flux to time, and to concentration difference across the actively transporting membrane are derived. The second of these equations is tested, using the isolated frog skin in the "short-circuit" apparatus of Ussing. Reasonable linearity, as predicted by this equation, is observed. The passive permeability coefficient for Na(+), is calculated as 5.3 x 10(-4) +/- 5.3 x 10(-4) cm./hr. If cholinesterase is assumed to be the enzyme responsible for transport, the activity required to account for the observations reported here is 17.7 x 10(-4) mmoles/cm.(2)/hr.


The influence of high hydrostatic pressure on cocaine and veratrine action in a vertebrate nerve. The application of high hydrostatic pressure to toad sciatic nerve causes a gain in sodium and a loss of potassium which are not affected by cocaine. However, cocaine action is enhanced by high pressure when counteracting veratrine depolarization and when blocking the action potential. Various effects of elevated pressure on the after-potentials are presented and the role of ions in these processes is discussed.


Effects of calcium lack on action potential of motor axons of the lobster limb. The effects of external calcium deprivation on certain characteristics of the action potential of the lobster motor axon have been studied. Upon exposure to calcium-free solution the spike amplitude is rapidly decreased within a few minutes and is followed by a slow linear decline. The rates of spike rise and fall are proportionally reduced more than the spike but follow similar time courses during calcium lack. Associated with these phenomena are the loss in the normal slow spike repolarization process, the development of a large and lengthy undershoot, and the appearance of a high degree of refractoriness. The mean increase in the refractory period is 525 per cent upon 10 minutes' exposure to calcium-free solution. These effects are completely reversible upon returning the axons to normal solution. These results are compared to similar effects of calcium deprivation on frog myelinated axons and squid and lobster giant axons recently observed by other workers.


Age and polyploidy of rat liver nuclei as measured by volume and DNA content.


The longevity and mortality of thoroughbred stallions.


Studies on the effect of heat and age in decreasing ability of human collagen to swell in acid.


Variation in appearance, cholesterol concentration, and weight of the chicken aorta with age and sex.


Age and swelling in acid of perivascular connective tissue in human lung.


The glucose-6-phosphate and 6-phosphogluconate dehydrogenase activities of arterial tissue in individuals of various ages.


Studies on the metabolism of the mucopolysaccharides of human arterial tissue by means of S35, with special reference to changes related to age.


Effects of age on the discrimination of lifted weights.


Physiological responses of five middle-aged and elderly men to repeated administration of thyroid stimulating hormone (thyrotropin; TSH).


Heart disease in old age. 1. Symptomatology and diagnostic procedures.


Psychotherapy with geriatric patients: a review of the literature.


The effect of age on taste sensitivity.

The effect of age on taste sensitivity.


Reorganization of perceptions with age.

Reorganization of perceptions with age.


Growth characteristics of adenoviruses. I. Production and release of complement fixing antigen and infectious virus.


Antigenicity of the inhibitor of influenza virus strain A/Asia/57.


The metabolism of some antigen-antibody complexes in the rabbit.


Immunochemical studies of poliovirus. IV. Alteration of the immunologic specificity of purified poliomyelitis virus by heat and ultraviolet light.


Studies on the transfer of lymph node cells. XIII. Effect of x-irradiation on lymph node cells incubated in vitro with Shigella-trypsin filtrate.


Sensitivity of pertussis inoculated mice to endotoxin.


Formation of bacterial protoplasts by serum components.


Concerning the mechanism of complement action. IV. The properties of activated first component of guinea pig complement.


The lack of bactericidal effect of mouse blood for nonvirulent group A streptococci.


Depression on normal serum bactericidal activity by nitrogen mustard.


Endotoxic and antigenic fractions from the cell wall of Salmonella enteritidis; methods for separation and some biologic activities.


Immunity afforded by specifically absorbed, unabsorbed and combinations of Salmonella antisera.


Role of hypothermia in cardiovascular surgery.


Xeroderma pigmentosum.

Xeroderma pigmentosum.


Primary tuberculosis of the stomach.

Primary tuberculosis of the stomach.


Treatment of mental diseases with chlorpromazine hydrochloride.


Diarrhoea, dysentery and colitis in Uttar Pradesh jails.


Hand-Schuller-Christian syndrome with complete destruction of scapula.


Polycystic disease of the lung with Mikulicz's syndrome.


Prostatectomy for senile enlargement of the prostate.


Dihydroergotamine in mumps.

Dihydroergotamine in mumps.


Adrenal cortical hypofunction in some cases of chronic amoebiasis.


Levinson's test in tuberculous meningitis.


Deficient nutritional states.

Deficient nutritional states.


Treatment of spinal curvatures.

Treatment of spinal curvatures.


Goitre in Mahableshwar Hills.

Goitre in Mahableshwar Hills.


Submucous fibrosis of the palate and buccal mucous membrane.


Sjögren's syndrome.

Sjögren's syndrome.


Sheehan's syndrome.

Sheehan's syndrome.


Supraspinatus tendinitis.

Supraspinatus tendinitis.


Acute pancreatitis; report of a case.

Acute pancreatitis; report of a case.


Recurrent mitral stenosis: an increasingly common occurrence due to inadequate mobilization of the valve.


Ovarium disjunctum; report of a case.

Ovarium disjunctum; report of a case.


The uterus and the products of inflammation: fundal keloid.


The Taranto operation in correction of genital prolapse.


Diseases of the cervical portion of the spine.


Flat foot.

Flat foot.


Coexistence of pulmonary carcinoma and active tuberculosis of the lung.


Carcinoma of the thyroid; an analysis of sixty-seven cases.


[Some aspects of carcinoma of the rectum].


Letheon: the cadenced story of anesthesia.


Gram's stain. Section 2.

Gram's stain. Section 2.


Hunter Holmes McGuire. Section 2.

Hunter Holmes McGuire. Section 2.


DR. KARL A. MEYER. Section 2.

DR. KARL A. MEYER. Section 2.


Joseph Bernard Murphy. Section 2.

Joseph Bernard Murphy. Section 2.


Hormone and enzyme mechanisms in sebaceous gland excretion.


Amount of ascorbic acid in normal epidermis.


Immunization against superficial fungous infection. I. Studies on experimental animals.


The effect of reserpine on urticaria pigmentosa.


Immunization against superficial fungous infection. II. Studies on human volunteer subjects.


Cross-sensitization in diverse poisonous members of the sumac family (anacardiaceae).


Rate of sebum excretion from the glands to the skin surface.


Hair roots of the human scalp in thyroid disease.


Effect of beta-radiation on mitotic activity in the skin of the young rat.


Distribution of lipids and free amino acids in psoriatic scale.


Studies on the chemical composition of human epidermal lipids.


National enrollment and the partnership between Blue Cross and Blue Shield.


The role of the practicing physician in public health.


Further observations on aminopterin for psoriasis.


The treatment of congestive heart failure.


Adrenalectomy for disseminated mammary cancer; a pilot study of sixteen patients.


Problems of anisometropia.

Problems of anisometropia.


The diagnosis and treatment of congenital pulmonary stenosis.


Arteriosclerosis obliterans of the lower extremity.


Pellagra in Ireland.

Pellagra in Ireland.


Cancer of the skin.

Cancer of the skin.


Why medical and psychiatric social workers.


First impressions of medicine in Nigeria.


Rupture of kidney, treated by partial nephrectomy.


The good general practitioner.

The good general practitioner.


Radiation; a public health approach.

Radiation; a public health approach.


Autopsy findings in suspected drowning.

Autopsy findings in suspected drowning.


Leonisone (601); a new anti-rheumatoid therapy.


Carcinoma of bronchus; review of cases.

Carcinoma of bronchus; review of cases.


Dumping syndrome; recent changes in concept of this common, distressing, and hence important, postgastrectomy development.


Esophageal atresia; report of successfully treated surgical case in a premature infant.


Control of pain; the most common complaint which prompts patients to seek medical aid.


Delayed cystography; a valuable diagnostic tool.


Diabetes; the search for the anti-diabetic hormone.


The rural water supply; outline of program in Kansas for providing safe and palatable water.


Economics in medicine; business expenses must be controlled.


Skin cancer; the sun as a carcinogenic agent.


General practice in Kansas; study in selected communities of less than 3,000 population.


Rural health; development and success of the Kansas plan.


Making agriculture safe; an analysis of the problem and its solution.


Rural practice; the appeal of a small community to a physician.


Geriatrics; old and sick; down on the farm.


Food for thought; the relationship of nutrition to the practice of medicine.


Hearing conservation; an outline of the plan for school children in Kansas.


The teeth; measures preventing caries and malocclusion lead to good dental health.


Tuberculosis; case-finding, diagnostic facilities, and treatment in Kansas.


Recent trends in the surgery of diverticulitis.


Some errors of omission and commission which lead to repeated gynecologic surgery.


The significance of bladder dysfunction.


The traumatic spleen.

The traumatic spleen.


Acute cecitis.

Acute cecitis.


Care of the tracheotomized patient.

Care of the tracheotomized patient.


Case of myxedema with pericardial effusion.


Report on the poliomyelitis immunization program in Kentucky; October, 1955-April, 1958.


Pregnancy in the congenitally malformed uterus.


Some medical emergencies of the newborn.


Convulsive disorders of children.

Convulsive disorders of children.


How useful is simple scalene lymph node biopsy.


Coccygodynia; an analysis of 100 cases.

Coccygodynia; an analysis of 100 cases.


Round worm infestation as seem by the surgeon.


Hematuria.

Hematuria.


A CASE of shigellosis.

A CASE of shigellosis.


Renal hemodynamics in patients with coarctation of the aorta.


The distribution of lipid and phospholipid in paper electrophoresis of the serum lipoproteins in normal subjects and in patients with atherosclerosis.


Folic acid and vitamin B12 in pernicious anemia; studies on patients treated with these substances over a ten year period.


The differing mechanisms of action of mercurials, carbonic anhydrase inhibitors, and chlorothiazide as diuretic agents.


On the zone electrophoresis of human parotid saliva in starch gels.


Relationship of equilibrium of distribution, biologic decay rates, and spece and mass of H3, Cl36, and Rb86 observed simultaneously in a comfortable and in a hot and humid environment in control subjects and in patients with congestive heart failure.


Studies of the influence of comfortable and hot & humid environments upon the rate of excretion of H3, H20, Cl36, Cl35, Na23, Rb86, and K39 in control subjects and patients with congestive heart failure.


The preservation of blood for transfusion. III. Mechanism of action of containers on red blood cells.


In vitro studies on the preservation of marrow cells in glycerol at low temperatures.


Observations on the site of production of Castle's intrinsic factor in the rat.


Evaluation of a method of direct left heart puncture.


Quantitative determination of free lysine in urine by two-dimensional paper chromatography.


Differential ultraviolet spectrophotometric determination of serum salicylates.


Naturally acquired toxoplasmosis in the gray squirrel, Sciurus griseus, and its bearing on the laboratory diagnosis of rabies.


The finding of urinary proteose in certain renal diseases; isolation and identification.


Effects of ionic strength on the ralative mobility of abnormal serum proteins.


Albumin metabolism in nephrotic adults.

Albumin metabolism in nephrotic adults.


Changes in body composition during the course of acute anterior poliomyelitis.


The absorption of vitamin B12 labeled with radioactive cobalt 60 following subtotal gastrectomy.


The effect of digitalis and desoxycorticosterone acetate administration upon intracellular potassium ion concentration; a chemical and morphologic study.


D-xylose and potassium iodide absorption and serum carotene in pernicious anemia.


Studies in leukemia. IX. The induction of leukemia in adult C3H mice by means of cell-free brain filtrates.


Serologic reactions in adenovirus disease. I. Delayed complement-fixing antibody response.


Mixtures of coagulase-positive staphylococci and strain variation in specimens from clinical sources.


Role of adrenal hormones in lymphocyte mobilization in the rat.


Production of magnetically controlled vascular obstruction.


The estimation of angiotensin in blood.

The estimation of angiotensin in blood.


A new precipitation method for estimating serum beta lipoproteins.


A method for preparing intact animals for carcass analyses.


A rapid automatic semimicro colloid osmometer.


Quantitative bacteriologic study of tissues, fluids, and exudates; some simplified methods.


An accurate device for the measurement of distance on the electrocardiogram and other permanent records.


Influence of fungus strain and lapse of time in experimental histoplasmosis and of volume of inoculum in cryptococcosis upon recovery of the fungi.


A practical method for the separation of lymphocytes from granulocytes.


Preparation of a human plasma fraction rich in prothrombin, proconvertin, Stuart factor, and PTC and a study of its activity and toxicity in rabbits and man.


Prevention and treatment of infections in bone.


Digitalis: its use and abuse; literature review.


Peptic esophagitis.

Peptic esophagitis.


Chickenpox.

Chickenpox.


Therapy of allergic and nonallergic asthma.


Treatment of mild depression with deanol para-acetamidobenzoate.


WINCHELL McK. CRAIG, M.D.; admiral of the ocean seas.


Management of chronic pain in general practice.


Some observations on the histology and function of the larynx.


The treatment of nonspecific allergic rhinitis.


On the nature and significance of hypocellularity of the mastoid.


The pneumatization of the temporal bone: a new concept.


Otitis externa; a limited study in Germany and Cyprus.


Bilateral malignant melanomata of the tonsils.


Gangrene of the tonsil.

Gangrene of the tonsil.


Chordoma of the oropharynx.

Chordoma of the oropharynx.


Malformations of the auricle: supplement. I.


Surgery of the gallbladder and bile ducts.


Prophylactic use of glucosamine-potentiated antibiotics in emergency abdominal and gastrointestinal surgery.


Hip joint prosthesis: sovereign remedy or profligate tool.


Management of congenital cataracts in children.


The general practitioner and psychiatry.


The setting up of a cardiac clinic in industry.


Prochlorperazine in a psychotic geriatric group.


The use of prochlorperazine in surgery.

The use of prochlorperazine in surgery.


Fractures of the elbow in children.

Fractures of the elbow in children.


Dextro-chlorpheniramine (polaramine) in allergy: preliminary report of 75 patients and comparison with racemic chlorpheniramine (chlor-trimeton) in 39 patients.


[Scleroderma in spots or white-spot disease].


[Remarks on the diagnosis, incidence & treatment of virus bronchopneumopathies].


The present status of intracardiac surgery.


The use of ACTH and steroids in the treatment of ulcerative colitis and regional enteritis.


A clinical evaluation of intramuscular trypsin in the treatment of acute thrombophlebitis.


Parenteral methylphenidate HCI (ritalin) in barbiturate poisoning.


Oxygen control policies for premature infants in Georgia.


Carcinoma of the larynx.

Carcinoma of the larynx.


Cancer page, professional education program.


Influences of the first faculty of the Medical College of Georgia upon the American medical curriculum and the origin of the American Medical Association.


Hypoglycemia and the heart.

Hypoglycemia and the heart.


Management of congenital deformities in infancy.


Sluder's headache and allied neuralgias.


Surgical treatment of shock in severe industrial injuries and war wounds.


Dorsal stands for spica cast.

Dorsal stands for spica cast.


Ligation of internal mammary artery in treatment of angina pectoris.


Chronic venous insufficiency.

Chronic venous insufficiency.


STANDARDIZATION of insurance claim form.


The carcinoid story.

The carcinoid story.


The leukemias.

The leukemias.


The problem of the change.

The problem of the change.


The American Medical Association; medical school partnership.


Education for the professions in Europe and in the United States: Alan Gregg Lecture.


Dr. John Delamater, true physician.

Dr. John Delamater, true physician.


Visual teaching aids in a gynecological department.


The seventh annual report of the National Intern Matching Program.


Post-examination training program in the Maharaja Sayajirao University of Baroda, India.


Current medical education in Japan.

Current medical education in Japan.


Medical practice from '58 to '78.

Medical practice from '58 to '78.


Address to the 1958 graduating class George Washington University School of Medicine.


The expanding frontier of cytology.

The expanding frontier of cytology.


The patient's team.

The patient's team.


Coagulation defects and pregnancy.

Coagulation defects and pregnancy.


Massive intraperitoneal hemorrhage due to paracentesis.


Cancer of the large bowel.

Cancer of the large bowel.


Blood levels and urinary excretion of a long-acting sulfonamide.


A fluoroscopic sign of pulmonic stenosis.


The place of physical treatments in psychiatry.


Leonhard's classification of schizophrenia.


A clinical and metabolic study of acute intoxication with Cannabis sativa and its role in the model psychoses.


The clinical differentiation of Pick's disease.


Mental disorder in rural Ghana.

Mental disorder in rural Ghana.


A retrospective controlled study of leucotomy in schizophrenia and affective disorders.


Treatment of anxiety states. I. The effects of suggestion on the symptoms of anxiety states.


Treatment of anxiety states. II. Clinical trial of benactyzine in anxiety states.


Treatment of anxiety states. III. Components of anxiety and their response to benactyzine.


Electroplexy (E.C.T.) techniques in current use; a report of a questionnaire recently circulated to hospitals.


The relationship between glucose tolerance, body weight, and clinical state in melancholia.


Trends in the development of physiology of the brain.


Psychological effects of centrally acting drugs in man; effects of chlorpromazine secobarbital on visual and motor behaviour.


The diagnostic and predictive accuracy of the wechsler memory scale in psychiatric patients over 65.


The diagnostic and predictive accuracy of the modified word learning test in psychiatric patients over 65.


Experimental studies of the mental speed of schizophrenics. I. Effects of a stimulant and a depressant drug.


Experimental studies of the mental speed of schizophrenics. II. Effects of practice.


Measurements of effects of hyaluronidase in insulin coma treatment.


Body fluid indoles of normal and mentally-ill subjects. I. Preliminary survey of the occurrence of some urinary indoles.


The effect of auditory stimulus intensity on the reaction time of schizophrenics.


Phenytoin toxicity with associated meningeal reaction.


Susceptibility to methylpentynol: eyelid conditioning and P.G.R. response.


Distance constancy in schizophrenic patients.


A clinical trial comparing prochlorperazine (stemetil) with chlorpromazine (largactil) in the treatment of chronic psychotic patients.


The use of prochlorperazine (stemetil) in chronic psychotic disorders.


Stelazine (trifluoperazine) a preliminary report on a clinical trial.


The effects of promazine (sparine) in chronic schizophrenia.


General paresis complicating Huntington's chorea.


Persistent psychiatric disorders after head injuries in children.


A controlled investigation of the effects of cyclizine hydrochloride in chronic psychosis.


Effects of LSD-25 on tests of personality.


Alleviation of the psychological effects of LSD in man by 5-hydroxytryptophan.


Cancer quackery.

Cancer quackery.


The phrenotropic drugs in mental illness.


Newer therapeutic weapons against disorders of the nervous system.


The misuse of sympathy.

The misuse of sympathy.


Use of ectylurea (nostyn) in mentally retarded patients; preliminary report of effects on seizures and spasticity.


Public relations and the patient.

Public relations and the patient.


Speech techniques in aphasia and parkinsonism.


Choledochoduodenostomy using a polyethylene tube prosthesis.


Serum transaminase determination in the differential diagnosis of jaundice; surgical aspects.


Psychological states as factors in the development of malignant disease: a critical review.


Polycythemia.

Polycythemia.


Effect of carcinogenic dosage and duration of exposure on skin-tumor induction in mice.


Modern concepts in the medical treatment of glaucoma.


Separation from a love object as an etiological factor in functional uterine bleeding.


Immunoelectrophoretic characteristics of normal mouse serums as a basis for studying pathological changes in serums of mice carrying transplantable malignant growths.


A method of analyzing electrocardiac entities in space. V. A three-dimensional statistical technique: its application to the ventricular gradient.


Immunoelectrophoretic studies of serums from mice carrying two transplantable plasma-cell leukemias.


Pathogenicity of a viral strain (RPL12) causing avian visceral lymphomatosis and related neoplasms. I. Nature of the lesions.


Pathogenicity of a viral strain (RPL12) causing avian visceral lymphomatosis and related neoplasms. II. Hostvirus interrelations affecting response.


Quantitative biological experimentation in the virus and cancer fields.


Ophthalmodynamometry.

Ophthalmodynamometry.


Granulomatous terminal ileitis; segmental granulomatous colitis. Gastritis and duodenitis, granulomatous?


Glomus jugulare tumor with hugh intracranial extension demonstrated by carotid angiography.


Terminal granulomatous ileitis, earliest roentgen findings.


Induction of tumors in rats by tissue-culture preparations of SE polyoma virus.


Smoking and lung cancer: recent evidence and a discussion of some questions.


Segmental colitis, granulomatous.

Segmental colitis, granulomatous.


Large ileocecal duplication in a newborn with bleeding.


Papillary carcinoma of the thyroid of long-standing; typical pulmonary and bony metastases.


A case of emphasis on scientific methods in the practice of medicine.


Gastroduodenal intussuception due to a myoma.


Coronary heart disease: physio-pathology and treatment.


The use of atarax in tuberculosis; a closed study.


Experiences with thoracic surgery in a community hospital.


Research trends in cancer of the lung.

Research trends in cancer of the lung.


Renal failure 20 years after nephrectomy.


Medical hypnosis.

Medical hypnosis.


Lymphosarcoma of the mediastinum in children.


Some generally unrecognized problems among medical students.


Fever of undetermined origin: an approach to diagnosis.


Hypofibrinogenemia associated with abortion; a case report.


The interdependence of good health and good conduct.


The understanding of involuntary movements: an historical approach.


Tumors of the septum pellucidum and adjacent structures with abnormal affective behavior: an anterior midline structure syndrome.


The reenactment of the marriage neurosis in group psychotherapy.


Psychotherapy of the adolescent: a comparison with psychotherapy of the adult.


Alcohol, convulsions and tranquilizers: a clinical and electroencephalographic study.


Psychotherapy with lysergic acid diethylamide.


The application of triiodothyronine in the treatment of mental disorders.


Some effects of a new psychotogen in depressive states.


The use of doxylamine in schizophrenia: pitfalls in the evaluation of a new drug.


Analysis of the personality structure of 26 actual suicides.


Pharmacological selectivity manifested by agents acting upon the cortical dendritic spike and its slow after-effects.


The effects of chlorpromazine and secobarbital on the C.P.T.


The adrenochrome model and schizophrenia.


Survey of various aspects of transvestism in the light of our present knowledge.


Social forces and the neurotic process.

Social forces and the neurotic process.


Enzyme activities of giant squid axoplasm and axon sheath.


A method for multiple electrolyte analyses on small samples of nervous tissue.


Lipid biosynthesis in vitro by electrically stimulated rat sciatic nerves.


Comparative histochemistry of lipids in relation to myelination in rabbit brain.


Disposition of gamma-aminobutyric acid administered to mammals.


Individual, strain and age differences in cholinesterase activity of the rat brain.


Cholinesterase and lactic dehydrogenase activity in the rat brain.


Determination of glutamic acid, glutamine, glutathione and gamma-aminobutyric acid and their distribution in brain tissue.


Changes in the composition of the developing mouse brain during early myelination.


The effects of 2-deoxy-D-glucose on metabolism of slices of cerebral cortex incubated in vitro.


Symposium on encephalomyelopathies of infancy and childhood. I. Congenital varieties; introductory remarks.


Pathoarchitectonic studies of cerebral malformations. III. Arrhinencephalies (holotelencephalies).


Atresia and stenosis of the aqueduct of Sylvius with comments on the Arnold-Chiari complex.


Dysraphic states.

Dysraphic states.


Congenital vascular anomalies and their histopathology in Sturge-Weber-Dimitri syndrome (naevus flammeus with angiomatosis and encephalosis calcificans).


Small vascular malformations of the brain: their relationship to unexpected death, hydrocephalus and mental deficiency.


Symposium on encephalomyelopathies of infancy and childhood. II. Acquired varieties; introductory remarks.


Antenatal and paranatal circulatory disorders as a cause of cerebral damage in early life.


Sequelae of perinatal trauma.

Sequelae of perinatal trauma.


Demyelinating diseases with special emphasis on the metachromatic type (postnatal and early infantile).


Organization of visual afferents shown by spike components of cortical response.


Studies on kernicterus; relationship with sulfonamide intoxication, report on kernicterus in rats with glucuronyl transferase deficiency and review of pathogenesis.


Cerebral response in somatic area II of ipsilateral somatic I origin.


Blood pressure alterations secondary to amygdaloid and periamygdaloid after-discharges.


Respiratory neuronal activity in pons of cat.


Some functional properties of optically evoked potentials in cerebellar cortex of cat.


Preservation of high-order function in isolated somatic cortex in callosum-sectioned cat.


Single unit off responses to brief flashes in cat's optic tract.


Effects of asphyxia on galvanic skin reflex before and after spinal transection.


Origin of so-called cone action potential.


Responses to lateral geniculate radiation stimulation in cats with implanted electrodes.


Carotid insufficiency: diagnosis and surgical treatment; a report of twenty-one cases.


Avoidance of false angiographic localization of the site of internal carotid occlusion.


Early experiences with ultrasonic irradiation of the pallidofugal and nigral complexes in hyperkinetic and hypertonic disorders.


Experimental spasmodic torticollis.

Experimental spasmodic torticollis.


Arachnoidal proliferation and cystic formation in the spinal nerve-root pouches of man.


Rate of recovery of functioning in cats with rostral reticular lesions; an experimental study.


Pneumoencephalography with direct injection and positional directing of air.


Intradural extramedullary plasmacytoma; case report.


Meningiomas in two members of the same family (with no evidence of neurofibromatosis).


Postoperative dissemination of astrocytoma of the spinal cord along the ventricles of the brain; a case report.


Ascending spinal paralysis; case presentation.


Testicular changes in pantothenic acid-deficient rats.


Essential fatty acid deficiency. III. Effects of conjugated isomers of dlenoic and trienoic fatty acids in rats.


Supplementation of cereal proteins with amino acids. I. Effect of amino acid supplementation of corn-masa at high levels of protein intake on the nitrogen retention of young children.


Supplementation of cereal proteins with amino acids. II. Effect of amino acid supplementation of corn-masa at intermediate levels of protein intake on the nitrogen retention of young children.


The effect of dietary proteins on the level of plasma cholinesterase of rats.


Studies of amino acid supplementation and amino acid availability with oats.


Evaluation of lysine supplementation of infant formulas fed to rats.


Essential fatty acids in infant nutrition. II. Effect of linoleic acid on caloric intake.


Essential fatty acids in infant nutrition. III. Clinical manifestations of linoleic acid deficiency.


Some aspects of tryptophan metabolism in human subjects. I. Nitrogen balances, blood pyridine nucleotides and urinary excretion of N1-methylnicotinamide and N1-methyl-2-pyridone-5-carboxamide on a low-niacin diet.


The influence of orally-administered penicillin upon growth and liver thiamine of growing germfree and normal stock rats fed a thiamine-deficient diet.


Some aspects of tryptophan metabolism in human subjects. II. Urinary tryptophan metabolites on a low-niacin diet.


The replacement by thiazolidinecarboxylic acid of exogenous cystine and cysteine.


Plasma and blood volume changes in late and prolonged pregnancy.


The electrolyte composition of the human uterus in normal pregnancy and labour and in prolonged labour.


Ovarian activity following hysterectomy.


The uterine electrolytes in pre-eclampsia.


Reminiscences of fifty years medical practice, forty-seven of them spent in South Africa.


Analysis of neonatal mortality; with special reference to the incidence and results of foetal apnoea.


Endometriosis and retrograde menstruation; case report and review.


In vitro studies of the motility of the human uterus. III. The effects of adrenaline, noradrenaline and acetylcholine on the spontaneous motility in different parts of the pregnant and non-pregnant uterus.


Ectopia vesicae and split pelvis; an account of pregnancy in a woman with treated ectopia vesicae and split pelvis, including a review of the literature.


The prevention of eclampsia and severe pre-eclampsia.


Management of eclampsia; a record of 125 consecutive cases.


Bilharziasis of the pregnant uterus.

Bilharziasis of the pregnant uterus.


Pregnancy following fundectomy for adenomyosis; report of a case.


Oxyuris granulomata of the fallopian tube and peritoneal surface of an ovarian cyst.


Mixed mesenchymal tumours of the body of the uterus; a report of two cases.


Two unusual cases; ectromelus and osteogenesis imperfecta.


Phaeochromocytoma complicating pregnancy.


Experimental background for open heart surgery at the University Hospital, in Oklahoma City, Okla.


Dermatomyositis and systemic lupus erythematosus in childhood.


Genital tract discharge.

Genital tract discharge.


The role of radioisotopes in clinical diagnosis.


Identification of signal lights. II. Elimination of the purple category.


Scalene node biopsy.

Scalene node biopsy.


Liminal image size for conventional film readers.


Nitrogenous excretory products of Taenia taeniaeformis larvae.


Studies on Hydatigera taeniaeformis. I. Growth of the larval stage.


Occurrence of a Trypanosoma cruzi-like organism in some mammals from southwestern Georgia and northwestern Florida.


Experimental infection of young pigs following intranasal inoculation with nasal, gastric, or cecal trichomonads from swine or with Trichomonas foetus.


Vital staining of blood parasites with acridine orange.


The mechanism of transmission of Haemobartonella muris (Mayer) of rats by the spined rat louse, Polyplax spinulosa (Burmeister).


The anthelmintic effect of bephenium on Ancylostoma caninum.


Studies on the development of Dirofilaria tenuis Chandler 1942.


Bephenium, a new drug active against human hookworm.


Variation in the number of oral spines of Phagicola longicollis Kuntz and Chandler, 1956, and the description of P. inglei n. sp. (Trematoda: Heterophyidae).


The marine, dermatitis-producing cercaria of Austrobilharzia variglandis in California (Trematoda: Schistosomatidae).


Primatotrema macacae gen. nov., sp. nov. from Macaque Rhesus monkeys, and a redescription of Phaneropsolus oviforme Poirier (1886) Looss. 1899 (Lecithodendriidae).


Mazocraeoides olentangiensis, n. sp., a monogenetic trematode parasitic on the gills of the gizzard shad, Dorosoma cepedianum (Le Sueur).


A new species of Dicrogaster (Trematoda, Haploporidae) from Mugil cephalus in the Gulf of Mexico.


A new species of tick from the Trans-Pecos region of Texas.


A perfusion apparatus for maintenance and observation of schistosomes in vitro.


Chemotherapy of experimental schistosomiasis. I. Drug activity and mode of action of a new thioxanthone derivative.


The demonstration of the role of mediators in turpentine pleurisy in rats by experimental suppression of the inflammatory changes.


Studies on tissue cultures of human pathological thyroids.


Patchy permanent renal ischaemia.

Patchy permanent renal ischaemia.


The rheumatic process in the left auricular appendage.


Chemical injury of arteries.

Chemical injury of arteries.


Predominantly cutaneous forms of necrotising angiitis.


The effect of the continuous administration of diets containing tetracyclines and penicillin on the number of drug-resistant and drug-sensitive Clostridium welchii in the faeces of pigs and chickens.


Some growth requirements of Haemophilus influenzas and Haemophilus pertussis.


The association of arteriovenous angioma and saccular aneurysm of the arteries of the brain.


Diffuse cavernous haemangioma of the uterus.


An antibody to Castle's intrinsic factor.


Intracranial haemorrhage in mice receiving injections of glycerol.


Salivary gland tumours and their mucins.


Pulmonary vascular changes in Eisenmenger's complex.


Papillary tumours of the thyroid gland.

Papillary tumours of the thyroid gland.


The relations of mucopolysaccharides of vessels walls to elastic fibres and endothelial cells.


Siderosis following transfusions of blood.


The role of micro-emboli in the production of carditis in hypersensitivity experiments.


Oxalosis and primary hyperoxaluria.

Oxalosis and primary hyperoxaluria.


Oscillation of the intraleucocytic granules as a criterion of survival of the leucocyte and of the potency of cytotoxic agents.


The glomerular lesions of diabetes mellitus and their electron-microscope appearances.


Familial canine chondrodystrophia foetalis (achondroplasia).


The cytology of the pituitary gland in myxoedema.


Factors influencing the survival of liver cells during autolysis.


The experimental production of keratoacanthomas in the hamster and the mouse.


Infundibuloma.

Infundibuloma.


Metaplastic changes in the visceral pleura in a case of fibrocystic disease of the pancreas.


Massive epidermoid metaplasia with keratin cyst formation in a giant fibro-adenoma of breast.


Rapid screening of antifungal agents for in-vivo activity.


Cardiovascular surgery in a children's hospital. I. Acyanotic lesions; a review of 241 operations.


Plethora in the newborn infant associated with cyanosis and convulsions; a review of postnatal erythropoiesis.


Bone marrow studies in the newborn infant at high altitudes.


Intestinal polyposis with oral pigmentation (Peutz-Jeghers syndrome); report of a case with review.


A comparison of meprospan (sustained action meprobamate capsule) with other tranquilizing and relaxing agents in children.


The effects of kwashiorkor on the development of the bones of the knee.


Hypophosphatemic rickets due to glomerular and tubular renal insufficiency.


Handling parental pressure for T and A.

Handling parental pressure for T and A.


Fulminating purpura with gangrene of lower extremity necessitating amputation; case report.


Interscorer agreement for the Graham behavior test for neonates.


Phenylketonuria: an unusual case.

Phenylketonuria: an unusual case.


The Children's Medical Center Boston, Mass.


Protein-calorie malnutrition in tropical preschool children; a review of recent knowledge.


Rubella during pregnancy.

Rubella during pregnancy.


Some examples of the use of radioisotopes in medical research.


The distribution, excretion and metabolism of C14 labeled tripelennamine (pyribenzamine) by guinea pigs.


Localization of the site of action of chlorothiazide by stop-flow analysis.


Studies on the metabolic degradation of propoxyphene.


Pharmacology of stereoisomers of 1-methyl-5-(1-methyl-2-pentynyl)-5-allyl-barbituric acid.


Effects of various centrally acting drugs on fighting behavior of mice.


The effects of meprobamate and pentobarbital upon cortical and subcortical responses to auditory stimulation.


Effects of some steroid and nonsteroid lactones on potassium exchange and physiological properties of the isolated perfused guinea pig ventricle.


Studies on Veratrum alkaloids. XXVIII. The action of the erythrophleum alkaloids on the single twitch and on the veratrine response of the sartorius muscle of the frog.


The supersensitivity caused by cocaine.

The supersensitivity caused by cocaine.


Action of tricyclamol sulfate on gastric secretion of rats and dogs.


The pharmacological actions of oxypanamine, an alkaloid derived from the seeds of Ormosia panamensis.


An analysis of the histamine-like actions of oxypanamine.


Oxidative phosphorylation.

Oxidative phosphorylation.


Differential spectrophotometric morphine estimation.


The effect of splenectomy on the production of anaphylactic shock in the guinea pig and the rat.


Stability of vitamin B12. II. Protection by an iron salt against destruction by aneurine and nicotinamide.


Polyhydroxy (catechol ic) phenolic acids-the formation of m-hydroxy- and methoxy-derivatives in man.


Some 3-arylpropane-1:2-diols.

Some 3-arylpropane-1:2-diols.


The action of morphine and morphine-like analgesics applied intraluminally on the peristaltic reflex of the isolated guinea pig ileum.


Assay of promazine and its separation from chlorpromazine and promethazine.


The effect of sinusoidal stretching upon the activity of stretch receptors in voluntary muscle and their reflex responses.


The action of phlorrhizin on the intestinal transfer of glucose and water in vitro.


Measurement of the striations of isolated muscle fibres with the interference microscope.


Local activation of striated muscle fibres.


The effects of stimulation of the sympathetic nerve and of adrenaline on the flow of parotid saliva in sheep.


After-potentials in mammalian non-myelinated nerve fibres.


Ion fluxes during the action potential in Chara.


The effect of growth hormone and insulin on limb-bone rudiments of the embryonic chick cultivated in vitro.


Vasodilatation in the tongue and its relationship to plasma kinin formation.


The relationship of histamine and 5-hydroxytryptamine to anaphylactic shock in different species.


The effect of some respiratory manoeuvres on the heart rate.


Continuous and reflex secretion by the parotid gland in ruminants.


The response of the ampullae of Lorenzini to combined stimulation by temperature change and weak direct currents.


The theory of the transfer, through the walls of biological tubes, of solutes in a moving fluid.


Renal clearance of uncharged particles, as exemplified by thioureas.


The intestinal absorption of some dipeptides.


Studies on the water and electrolyte metabolism of the lizard Trachysaurus rugosus (Gray).


Competition between enantiomorphs of amino acids during intestinal absorption.


The effects of intravenous pyrogen upon the radiant heat induced vasodilatation in man.


The effects of factor I and of gamma-aminobutyric acid on smooth muscle preparations.


Reflex respiratory activity in the new-born rabbit.


Vision with controlled movements of the retinal image.


The effects of adrenaline and noradrenaline on pulmonary haemodynamics with special reference to the role of reflexes from carotid sinus baroreceptors.


Observations on spermine oxidase of mammalian plasma.


Autoradiographic localization of adenine nucleotide in frog's striated muscle.


Pharmacological investigations upon inhibition of spinal motoneurones.


Effects of muscle stretch on excitability of contralateral motoneurones.


Delayed effects of peripheral severance of afferent nerve fibres on the efficacy of their central synapses.


The loss of potassium from isolated rabbit atria.


The rationale of selective surgery in the treatment of duodenal ulcer.


In defence of eponyms.

In defence of eponyms.


Mechanical factors as a cause for gastrectomy failures.


Social insurance and rehabilitation.

Social insurance and rehabilitation.


The neuro-endocrine response to injury.

The neuro-endocrine response to injury.


The control of the hepatic arterial circulation.


The nutritional response of the burned child.


Serotonin and antidiuresis.

Serotonin and antidiuresis.


Concerning job readiness.

Concerning job readiness.


New light on post-traumatic antidiuresis.


Communication problems of the counselor.


The application of the maximal histamine test of gastric secretion to problems of peptic ulcer surgery.


Determining suitability of employment.

Determining suitability of employment.


Hormone assay in mammary carcinoma.

Hormone assay in mammary carcinoma.


The dynamics of the renal pelvis and ureter.


Communicating with the acoustically handicapped.


The role of the adrenal glands in the metabolic response to surgery.


The fate of patients referred for medical treatment of duodenal ulceration.


The cardiac seeks a job.

The cardiac seeks a job.


Psychiatric view of cardiac rehabilitation.


Current research in the homograft problem.


The treatment of idiopathic thrombocytopenic purpura.


Dysphagia following vagotomy.

Dysphagia following vagotomy.


Problems in education for general practice.


Experiences with the artificial kidney at the Medical College Hospital.


The treatment of thermal burns.

The treatment of thermal burns.


The incidence of gall stones.

The incidence of gall stones.


Electrocardiogram of the month; the stress electrocardiogram.


Incompetent internal cervical os; a case report.


Distribution of mortality from coronary artery disease in Tennessee 1949-1953.


Experience with arterial replacement.

Experience with arterial replacement.


Fenestration of the oval window.

Fenestration of the oval window.


Porphyria cutanea tarda.

Porphyria cutanea tarda.


Presentation of an unusual case of progressive exophthalmos.


Creation of a temporary artificial ductus for the surgical correction of ventricular septal defects associated with severe pulmonary hypertension; a two-stage operation.


Surgical treatment for the tetralogy of Fallot by open intracardiac repair.


Atrial septal defect, secundum; an analysis of one hundred patients undergoing open surgical repair.


Pressure membrane oxygenator.

Pressure membrane oxygenator.


Reconstruction of the thoracic aorta with the aid of a vascular coupling device (vessel couple); report of a case.


The anatomy of esophageal hiatus of the diaphragm and the pathogenesis of hiatus herniation.


Ciliary streaming through the larynx and trachea; relation to direction of ciliary beat and significance in sites of respiratory disease.


The metabolic effects of an intrathoracic stomach on a growing child.


Esophageal obstruction due to mediastinal granuloma.


The treatment of tuberculosis in the tropics.


Mycoses of Malaya and Singapore.

Mycoses of Malaya and Singapore.


[Surgical treatment of goiter and thyrotoxicosis].


[Study on essential pulmonary hemosiderosis].


[Clinical picture and treatment of influenza in 1956-1957].


[Recklinghausen's neurofibromatosis & myopia].


The bromsulphthalein excretion test in hypothyroid rats.


Prolonged intravenous administration of iron to normal and anemic rabbits.


Histochemical demonstration of the partial dissociation of succinic dehydrogenase complex by means of pretreatment of tissue sections.


Esophageal erosions in the newborn.

Esophageal erosions in the newborn.


Conference on Autoradiography; opening remarks.


Collagen content based on hydroxyproline determinations in human and rat livers; its relation to morphologically demonstrable reticulum and collagen fibers.


Matrix theory for quantitative evaluation of autoradiographs.


Grain counting instrumentation.

Grain counting instrumentation.


Autoradiography of in vitro activated sections of tissue as a tool in histochemistry, in relation to metabolic disorders and cancer.


Methods to improve the performance of stripping emulsions.


Quantitative evaluation of autoradiograms on the basis of track or grain counting.


Methods of automatic quantitation of microautoradiographs.


On the question of automatic or visual grain counting.


Liquid emulsion autoradiography with tritium.


The autoradiographic study of transplanted tissue.


The measurement of radiation dosage distribution by autoradiographic means with reference to the effects of bone-seeking isotopes.


Autoradiographic and histopathologic studies in radiation carcinogenesis of the lung.


Effect of irradiation with x-rays on the uptake of S35 sulfate by the epiphyseal cartilage of mice.


The use of autoradiography in the measurement of radiation dose-rate in rabbit bones following the administration of Sr90.


Autoradiographic study of the relation between nucleic acids and protein synthesis.


Autoradiography in the localization and radiation dosage of Ra226 and Pu239 in the bones of dogs.


The application of autoradiography in the study of nucleic acid metabolism.


The use of nuclear emulsion in the study of bacteriophage DNA replication.


The use of tritiated thymidine in the study of DNS synthesis and cell turnover in hemopoietic tissues.


Metabolic activity of DNA as shown by autoradiographs.


S35 autoradiographic studies on sulfomucopolysaccharides in the connective tissue of induced skin tumors in mice and Rous's fowl sarcoma I.


The effect of tritium on the interpretation of autoradiographic studies on chromosomes.


Studies on deoxyribonucleic acid metabolism in human cancer cell cultures (HeLa). I. The temporal relationships of deoxyribonucleic acid synthesis to mitosis and turnover time.


Studies of ribonucleic acid metabolism with tritium-labeled cytidine.


The diagnosis of prepsychotic schizophrenia.


The choice between death from postmaturity or prolapsed cord and life from induction of labour.


The syndrome of brachymetacarpal dwarfism (pseudo-pseudohypoparathyroidism) with and without gonadal dysgenesis.


Aortic thrombosis causing hypertension.

Aortic thrombosis causing hypertension.


Carcinoma of the lingual thyroid treated with radioactive iodine.


Nucleic acid metabolism of pancreatic cells as revealed by cytidine-H3 and thymidine-H3.


Intra-articular prednisolone 21: phosphate; a clinical trial.


CONFERENCE on Autoradiography; summary.

CONFERENCE on Autoradiography; summary.


Urinary osmolality and specific gravity.


Thymidine-H3 as a tool for the investigation of the renewal of cell populations.


Dangers of uric-acid excretion during treatment of leukaemia and lymphosarcoma.


Operating-table for hand surgery.

Operating-table for hand surgery.


Urinary corticoids in hypertension with observations on the effect of various Rauwolfia preparations.


Ruptured abdominal aneurysm in elderly patients: report of a case with recovery.


RENAL biopsy.

RENAL biopsy.


SLEEP.

SLEEP.


The "crotch dose" in the genital area: a radiation exposure survey.


Lupoid hepatitis and the hepatic lesions of systemic lupus erythematosus.


Acute regional enteritis with an unusual postoperative complication.


Hemiplegia: complication of ruptured intracranial aneurysm; prognosis for recovery following surgery.


Malnutrition in Uganda; examination of an official statement.


Results of treatment of carcinoma of the breast.


HUGH CRICHTON-MILLER.

HUGH CRICHTON-MILLER.


Pathogenesis and treatment of endocrine exophthalmos.


Testosterone in defective spermatogenesis.


Automatic diathermy switch and self-cleaning probe.


Malabsorption and jejunal ulceration due to gastric hypersecretion with pancreatic islet-cell hyperplasia.


Islet-cell tumour of pancreas associated with peptic ulceration.


IS PEPTIC ulcer an endocrine disease.

IS PEPTIC ulcer an endocrine disease.


The effect on human serum-lipids of a dietary fat, highly unsaturated, but poor in essential fatty acids.


The detection of antifoam emboli following perfusion with a heart-lung machine.


The hypotensive effect of chlorothiazide.


Antagonism between the effect of aldosterone and a synthetic steroid lactone on the renal excretion of sodium and potassium in man.


MITRAL incompetence.

MITRAL incompetence.


An Indian village.

An Indian village.


Experiences with a disposable plastic transfusion-giving set.


Rhinomanometry in some rhinologic diseases.


A study of the relationship of air pressure to myringorupture.


Laryngologic experience in bulbar poliomyelitis.


Studies of factors considered responsible for diseases of the external era. I. Survival of exogenous bacteria in the external auditory canal under varied conditions.


Studies of factors considered responsible for diseases of the external auditory canal. II. Evaluation of temperature and humidity as they influence the amount of ethersoluble substances in the external auditory canal.


Congenital bilateral complete bony choanal atresia.


Procaine convulsions.

Procaine convulsions.


CHEVALIER JACKSON.

CHEVALIER JACKSON.


Diethyl dithiolisophthalate in the treatment of leprosy. (ETIP or Etisul); a progress report.


A look at socialized medicine.

A look at socialized medicine.


Progressive systemic sclerosis: a review of cases at the MGH.


The psychological problems of chronic invalidism.


Introduction to an elementary theory of fine gels.


Case report.

Case report.


[Incidence of female genital tuberculosis in Békés county in connection with 143 cases detected in the last 5 years].


South Baltimore General Hospital.

South Baltimore General Hospital.


Automobile accidents: the multiple injury patient.


Idiopathic hemorrhagic infarction of the testis in the newborn.


Extracranial diagnostic problems associated with head injuries.


Injuries of the head and facial regions.


Spontaneous cerebrospinal rhinorrhea and otorrhea.


Traumatic cases and the laboratory services.


Whiplash injuries to the neck.

Whiplash injuries to the neck.


[Radiological study of the cervical spine in pilots of fighter planes].


The topography of ignorance; the cancer problem.


Hypnosis: an evaluation of its place in medicine.


The effects of thymectomy on the lymphocyte count in patients with myasthenia gravis.


Advances in service psychiatry abroad.

Advances in service psychiatry abroad.


A survey of pelvic carcinoma.

A survey of pelvic carcinoma.


The first successful operation for perforated peptic ulcer.


Pick's disease (circumscribed cortical atrophy).


Progress in psychiatry.

Progress in psychiatry.


Thirty years of juvenile rheumatism.

Thirty years of juvenile rheumatism.


Another look at the problem of lumbo-sacral pain and sciatica.


Some problems of lung cancer; a physician's viewpoint.


Some observations on the pathology and treatment of carcinoma of the lung.


The limitations of the radiological method in the diagnosis of carcinoma of the lung.


ROBERT OFFICER.

ROBERT OFFICER.


Not too much.

Not too much.


Fluid and electrolyte metabolism in childhood in health and disease.


Practical radiation protection.

Practical radiation protection.


Some aspects of the nephrotic syndrome in childhood.


Aspects of chronic gastritis.

Aspects of chronic gastritis.


Gastroscopy; a review of 1100 cases.

Gastroscopy; a review of 1100 cases.


Psoriasis: a physician's evaluation.

Psoriasis: a physician's evaluation.


Diet sheets for special diets from the department of dietetics, Royal Newcastle Hospital.


The management of the patient with a haemostatic defect during the period of surgery.


Medical secrecy in the law.

Medical secrecy in the law.


Fluoxymesterone (halotestin) in advanced breast carcinoma.


The failures of cholecystectomy.

The failures of cholecystectomy.


Observations on diabetic gangrene after restoration of circulation.


Aspiration liver biopsy in the diagnosis of miliary tuberculosis: report of a case.


Body-section radiography: thorax.

Body-section radiography: thorax.


Magicians and Meningiomas.

Magicians and Meningiomas.


Herniation of sigmoid colon and stomach into scrotum.


Spina bifida with meningocele.

Spina bifida with meningocele.


The roentgen identification of tuberculous cavities following antibiotic treatment.


Radiographic visualization of subdiaphragmatic air; oblique lateral projection with patient supine.


Calcium orthophosphate crystals in bones, joints, and soft tissues of a gibbon.


The sixth Francis Shepherd memorial lecture: The Nuclear Age.


The normal pneumoencephalogram.

The normal pneumoencephalogram.


Parkinson's disease: morbidity and mortality figures.


Baby pictures in the hospital.

Baby pictures in the hospital.


The medical restoration component in a comprehensive rehabilitation program.


Disorders of the medial meniscus.

Disorders of the medial meniscus.


Prevention of histamine induced ulceration by gastric mucosal excision in cats.


Acute gaseous cholecystitis.

Acute gaseous cholecystitis.


A report on studies on spinal traction.

A report on studies on spinal traction.


Incidence of coronary infarcts Canadian Army (regular) 1954-1957.


Severe respiratory failure with recovery.


The current status of disability evaluation under the disabled persons allowances program.


CORONER'S corner.

CORONER'S corner.


Toxemia of pregnancy.

Toxemia of pregnancy.