Granuloma of the bladder following inguinal herniorraphy: report of case with gross hematuria.


Studies in detoxication. 79. The metabolism of cyclo [14C] hexane and its derivatives.


Haemorrhage and tissue electrolytes.

Haemorrhage and tissue electrolytes.


The effect of chlorpromazine on the respiratory chain; cytochrome oxidase.


An unusual property of thyroxine and other iodophenols.


Acetylcholinesterase in goldfish muscles; studies on some substrates and inhibitors.


A new aspect of the interaction between thyroxine and proteins.


The translocation of antibiotics in higher plants. 3. The estimation of griseofulvin relatives in plant tissue.


The translocation of antibiotics in higher plants. 4. Systemic fungicidal activity and chemical structure in griseofulvin relatives.


The metabolism of glycerol in Mycobacterium butyricum.


Enzymic studies of x-irradiated cornea and lens with special reference to glutathione reductase.


Cerebral metabolism in the sheep. 1. Normal sheep.


Cerebral metabolism in the sheep. 2. Irreversible hypoglycaemic coma.


Studies on phospholipids. 5. The separation of dinitrophenylated and methylated phospholipids by countercurrent distribution.


Molecular structure of glycogens isolated from the livers of foetal animals.


The occurrence of methylated guanines in ribonucleic acids from several sources.


Degradation of the hyaluronic acid complex of synovial fluid by proteolytic enzymes and by ethylenediaminetetra-acetic acid.


Factors influencing the incorporation of amino acid into the protein of microsome and mitochondria preparations of rat liver and liver tumour.


A quantitative method for the separation of thyroid hormones and related compounds from serum and tissues with an anion-exchange resin.


Thyroid-hormone metabolism in the kidney.


The identification of the acetic acid analogues of thyroxine and tri-iodothyronine in mammalian tissues.


The biosynthesis of polyacetylenes. 2. Origin of the carbon atoms.


Studies in the biochemistry of micro-organisms. 106. Metabolites of Alternaria tenuis auct.: the structure of tenuazonic acid.


The amide and carboxyl groups of bacitracin A.


Oligosaccharide synthesis in the banana and its relationship to the transferase activity of invertase.


Fungal detoxication. 4. Metabolism of 2-methoxynaphthalene by Aspergillus niger.


The mechanism of ficin-catalysed reactions.


The effects of adenosine triphosphate on the mechanical properties of surface films of L-myosin and actomyosin.


The copper content and cytochrome oxidase activity of tissues from normal and swayback lambs.


The in vivo foetal oxygen dissociation curve.


Production of skeletal malformations in the offspring of pregnant mice treated with 6-aminonicotinamide.


Multiple inherited erythrocyte abnormalities in an American Negro family: hereditary spherocytosis, sickling and thalassemia.


Long-term mixed cultures of human hemic cells, with granulocytic, lymphocytic, plasmocytic and erythrocytic series represented.


The influence of chemotherapy on survival in acute leukemia; comparison of cases treated during 1954 to 1957 with those treated during 1947 to 1954.


The mechanism of the anemia associated with Hodgkin's disease.


Lymph node reactivity. II. Fetal lymph nodes.


A review of lesions in the optic fundus in various diseases of the blood.


Serum lactic dehydrogenase and serum transaminase in human leukemia.


Trauma of the central nervous system.

Trauma of the central nervous system.


Serum uric acid levels in adult males in Puerto Rico.


The influence of enzymolitic agents on experimental liver necrosis in rats by tolura diet.


Actinomycosis of the mandible.

Actinomycosis of the mandible.


Carlos Chagas.

Carlos Chagas.


[Postoperative chondritis of the ribs].

[Postoperative chondritis of the ribs].


[Ultrastructure characteristics of the nucleoli in maturing oocytes of various species of mollusks].


[Metabolic effects of desamethazone].

[Metabolic effects of desamethazone].


The ear oximeter as a circulatory monitor. II. The infrared pulse, a moment-to-moment guide to cardiac output.


Hypotension due to halothane.

Hypotension due to halothane.


Atropine as an antisialogogue, compared with l-hyoscyamine (bellafoline), scopolamine butylbromide (buscopan) and oxyphenonium (antrenyl).


Some details of a technique for hypothermia.


Incompatible blood transfusions during operation.


A strain gauge for physiological use; a preliminary communication.


A case of myocardial infarct under anaesthesia.


An investigation of the validity of death certification of cancer of the lung in Leeds.


Cancer of the mouth: 11-year follow-up of 800 cases.


A comparison of treated and untreated cases of cancer of the breast.


Early diagnosis of malignant conditions in lymph nodes.


Tumour cells in the blood with special reference to pre- and post-hepatic blood.


Reticulin patterns in tumours of lymphoid tissue.


Hormone excretion in prostatic cancer: an attempt to correlate urinary hormone excretion and clinical state.


The effects of age on the structure and response to oestrogens and testosterone, of the mouse prostate in organ cultures.


A survival curve for mammalian leukaemia cells irradiated in vivo (implications for the treatment of mouse leukaemia by whole-body irradiation).


The early development of tumours in mice inoculated with a cellfree filtrate of mouse leukaemic tissue.


The effect of applying croton oil before a single application of 9,10-dimathyl-1,2-benzanthracene.


Oil of sweet orange: a possible role in carcinogenesis.


Studies of the carcinogenic action of tricycloquinazoline.


Mammary carcinoma incidence in C3Hf virgin female mice after ovariectomy and substituted oestrone.


The influence of sex and castration on the induction of skin tumours in mice by methylcholanthrene.


Demonstration and significance of independently growing mammary carcinomas within the cardiac lumina in mice, with epithelial and stromal differentiation.


An intestinal carcinoma in mice following injection of herring-sperm deoxyribonucleic acid.


Vehicular exhausts: identification of further carcinogens of the polycyclic aromatic hydrocarbon class.


In vitro uptake of 14C labelled glycine by the cells of pleural and peritoneal fluid.


On the correlation between metabolic and structural changes during carcinogenesis in rat liver.


Scarlet fever.

Scarlet fever.


Diet and ischaemic heart disease.

Diet and ischaemic heart disease.


Chondrodystrophy, achondroplasia of the foetus in obstetrics.


The surgical approach to parkinsonism.

The surgical approach to parkinsonism.


Ventilation and disease.

Ventilation and disease.


Ileostomy in the treatment of ulcerative colitis.


A new treatment for the sore throat.

A new treatment for the sore throat.


Tenosynovitis.

Tenosynovitis.


Orthopaedics.

Orthopaedics.


The skin clinic.

The skin clinic.


Abusive rhinology.

Abusive rhinology.


The treatment of some common disorders. 6. Hypertension.


Local antibiotics in skin infections.

Local antibiotics in skin infections.


A trial of trimeprazine in itching dermatoses.


Comparison of topical steroids.

Comparison of topical steroids.


Porphyria during chloroquine therapy.

Porphyria during chloroquine therapy.


Arterial thrombosis apparently due to steroid treatment.


The changes of Shigella shigae toxin toxicity induced by phenol.


Antibodies against nuclear and cytoplasmic cell constituents in systemic lupus erythematosus and other diseases.


The nature of the connective tissue defect produced by the aminonitriles.


Observations on the pathology of toxoplasmosis in the cotton rat.


The pituitary remnant after partial hypophysectomy in the rat.


The significance of renal glucose-6-phosphate dehydrogenase in experimental hypertension in the rat (a histochemical study).


Biochemical studies on experimental cardiopathy: electrolytes in rat tissues.


The use of acquired immunological tolerance and immunological paralysis in the study of the antigenic relationships of normal and abnormal serum globulins.


The relationship of tissue formation and destruction to the levels of the serum protein-bound carbohydrate in rats bearing the Walker 256 carcinoma.


Use of foetal haemopoietic tissue to prevent late deaths in rabbit radiation chimaeras.


The effect of Mycobacterium tuberculosis (BCG) infection on the resistance of mice to bacterial endotoxin and Salmonella enteritidis infection.


The interference of mouse hepatitis virus with ectromelia in mice and a possible explanation of its mechanism.


Clinical research in schizophrenia; the psychotherapeutic approach.


On assessing the results of psychotherapy.


Psychological factors in muscular pain.

Psychological factors in muscular pain.


The husband-wife relationship in cases of puerperal breakdown.


Spontaneous traumatic reactions to hypnosis.


Incentives with paranoid and non-paranoid schizophrenics in a workshop.


Bracken (Pteridium aquilinum); the effect of steaming on the nutritive value of bracken hay.


A shortened version of the Mitchell method for determination of the biological value of protein; growth rate as a source of error.


Biological value of herringmeal protein; urinary nitrogen excretion in relation to protein content of diet and food intake.


The nutritive value of bread protein as influenced by the level of protein intake, the level of supplementation with L-lysine and L-threonine, and the addition of egg and milk proteins.


The use of Dolichos lablab and Lathyrus sativus in the making of taamiah (bean cakes) in Egypt.


A re-examination of the effect of vitamin B12 concentrate on the hepatic injury produced by carbon tetrachloride.


Studies of the nutrition of the young calf. II. The nutritive value of unhydrogenated palm oil, unhydrogenated palm-kernel oil, and butteriat, as additions to a milk diet.


Diet in pregnancy. II. Assessment of the nutritive value of diets, especially in relation to differences between social classes.


The effects of continuous administration of penicillin to successive generations of chicks.


The metabolism of nitrogen, calcium and phosphorus in undernourished children. V. The effect of partial or complete replacement of rice in poor vegetarian diets by ragi (Eleusine coracana) on the metabolism on nitrogen, calcium and phosphorus.


The effect of white scours on the sodium and potassium concentration in the serum of newborn calves.


Serum-cholesterol levels and atherosclerosis: effects of composition of diet and tri-iodothyronine on the rat.


Chymotrypsin and zonulysis; preliminary communication.


Some observations on the use of chymotrypsin.


Corneal vascularization after cataract extraction by zonulysis.


Epiphora due to weak lid muscles.

Epiphora due to weak lid muscles.


Classification of amblyopia.

Classification of amblyopia.


Episkopi blindness; hereditary blindness in a Greek Cypriot family.


Scleral buckling operation with rolled scleral flap.


Solar retinitis.

Solar retinitis.


Subconjunctival lymphoma.

Subconjunctival lymphoma.


Sarcoidosis; swellings on the nose and late ocular sequelae.


Optic atrophy after small-pox.

Optic atrophy after small-pox.


The effect of alkylating agents on male rat fertility. The effects of tumour inhibitory doses of tretamine (triethylenemelamine), busulphan, and melphalan on the fertility of male rats have been examined. The aromatic nitrogen mustard, melphalan, was inactive, but busulphan has a highly selective action on spermatogenesis which contrasts strikingly with that of tretamine. The main action of tretamine was exerted upon spermatocytes or spermatids, but, with increasing dose, the effects spread to involve a wide range of spermatogenic cells including mature sperm, so that infertility could be induced very rapidly. Busulphan, however, interfered with the development of spermatogonia for several weeks, although other germinal cells were unaffected and continued to develop into mature spermatozoa. This accounted for the continuation of normal fertility for 7 weeks after a dose, before sterility suddenly developed. The antifertility activity of tretamine could be simulated by a variety of other ethyleneimino compounds, potency being greatest in trifunctional and least in monofunctional compounds. The latter were, however, very destructive to the seminiferous epithelium with increasing dose. In the rat, there appeared to be no definite relationship between the ability of alkylating substances to interfere with the activity of normal and pathological proliferating tissues, as represented by the germinal epithelium, haematopoietic, and tumour tissue. Although carcinogenicity was a biological property of alkylating agents, other chemical types of carcinogen did not interfere with fertility.


Assay of suxamethonium and laudexium on the frog rectus abdominis. Suxamethonium, like acetylcholine, causes contracture of the isolated rectus abdominis muscle of the frog, whereas laudexium antagonizes this effect. These actions may be used to assay both drugs with reasonable speed and fiducial limits, provided that changes in responsiveness of the preparation during the course of assay are met by suitable design and analysis. Small quantities of suxamethonium and laudexium may be assayed in certain body fluids.


Increase of 5-hydroxytryptamine in the rat brain by raunescine. The Rauwolfia alkaloid raunescine (5 mg./kg., intraperitoneally) increased the concentration of 5-hydroxytryptamine in the brains of rats after iproniazid pre-treatment. This was evident 3 to 4 hr. after raunescine administration. There was no general increase in the noradrenaline content of the brains. In the intestine, raunescine depleted the 5-hydroxytryptamine content by about 50% within 3 to 4 hr. if the animals had been pre-treated with iproniazid. Iproniazid did not increase the content of noradrenaline in the intestine.


The comparative toxicity of antibiotics to skin. The toxicity of sixteen antibiotics to skin in vitro was investigated by a microrespirometer technique and by the histological appearance of 3-day cultures. There was close agreement between the results obtained by the two methods and between tests with human and with guinea-pig skin. Antibiotic concentrations which caused more than 30% respiratory damage after one day invariably produced abnormal cultures, and more than 60% respiratory damage often resulted in necrotic cultures. Dose/response curves were obtained for the effect of antibiotics upon skin respiration. Mathematical evaluation had little advantage over visually fitted dose/response curves. The ED50 provided a reproducible measure of the relative toxicity of different antibiotics to skin, but the ED30 probably provided a better comparison because this was the highest concentration of antibiotic which permitted migration of epithelium. Many antibiotics at therapeutic concentrations show little toxic effect upon skin in vitro. It is suggested that the healing of surface lesions might well be retarded if the antibiotic concentration found toxic in vitro were maintained at a similar concentration in vivo.


The duration of action of some cardiac glycosides and aglycones in the guinea-pig. A method is described for determining the duration of action of cardiac glycosides and aglycones in the guinea-pig. It is based on their property of potentiating the cardiac response to adenosine. The method is particularly suitable for those drugs with a short duration of action, whereas previous methods are more suitable for those drugs with longer durations of action. The duration of action of one-fifth of the lethal dose has been found for: digoxigenin, lanatoside C, ouabain, digitoxigenin-3-one, digitoxin, 3-acetyldigitoxigenin, digoxin, digitoxigenin, lanatoside A; these drugs are arranged in order of increasing duration of action. The possible relationship between the elimination of these drugs and their duration of action can provide an estimate of their rates of elimination.


Effect of histamine on ganglionic transmission. Histamine has been shown to depress transmission through the perfused superior cervical ganglion of the cat when doses of 150 mug. or more were administered. The intensity of the ganglionic block was related to the dose of histamine employed. In one-third of the experiments, a slow contracture of the nictitating membrane occurred after histamine had been injected; the contracture lasted up to 10 min., and subsequent injections of histamine gave rise to progressively smaller responses. The blocking action of histamine was evident in all experiments and was the most prominent feature observed. Histamine in a sub-depressant dose enhanced the action of the competitive blocking agents tetraethylammonium and hexamethonium, and also the depolarizing blocking agents tetramethylammonium and nicotine. The possible physiological rôle of histamine in the autonomic nervous system is discussed.


The relation between temperature and changes in ion concentration on ventricular fibrillation induced electrically. Further observations have been made on ventricular fibrillation induced by electrical stimulation in the isolated rabbit heart, in extension of the finding that fibrillation was arrested by cooling from 37 degrees to 32 degrees . The observations now made suggest that at 37 degrees the isolated rabbit heart perfused with Locke solution is on the edge of anoxia, but that at 32 degrees the oxygen supply is adequate. At the lower temperature the proportion of hearts fibrillating at any given potassium concentration was reduced, so, although the proportion of hearts fibrillating rose as the potassium concentration fell, even when the latter was one-quarter of the normal the proportion was not higher than 67%. The relation of the concentration of calcium ions to the proportion of hearts fibrillating changed from biphasic at 37 degrees to almost rectilinear at 32 degrees , the proportion increasing as the concentration of calcium ions rose. It was confirmed that a reduction in sodium concentration also raises the proportion of hearts fibrillating.


Oximes of alpha omega-diquaternary alkane salts as antidotes to organophosphate anticholinesterases. Sixteen compounds of the general structure {HON: CH.C(5)H(4)N(+).[CH(2)](n).R(+)}2Br(-) have been synthesized in which the position of the oxime group in the pyridine ring, the second charged group R(+) and the number of methylene groups between the charged atoms have been varied. The rate at which these compounds reactivate cholinesterase inhibited by ethyl pyrophosphate has been studied and a number have been found which are more active than 2-hydroxyiminomethyl-N-methylpyridinium methanesulphonate. Since considerable variation in structure was found among those compounds which are better reactivators than the latter, the concept that 2-hydroxyiminomethyl-N-methylpyridinium salts are unique in their ability to fit the surface of the inhibited enzyme is no longer tenable. The reactivating power of these oximes correlated well with their ability, when given in conjunction with atropine, to save the lives of mice poisoned by ethyl pyrophosphate. The most effective compounds, NN'-trimethylenebis-(4-hydroxyiminomethylpyridinium bromide) and NN'-hexamethylenebis(2-hydroxyiminomethylpyridinium bromide), contained a further oxime group in R(+), but the second oxime group was not essential for high activity. These new oximes were also superior in saving the lives of mice poisoned with sarin (isopropyl methylphosphonofluoridate), but the improvement was not as dramatic as when the mice were poisoned with ethyl pyrophosphate. The toxicity of the compounds varied with both n and R(+) and was unrelated to the therapeutic potency.


Absorption, metabolism and elimination of pempidine in the rat. Pempidine (1,2,2,6,6-pentamethylpiperidine) is a ganglion blocking agent introduced recently for the treatment of hypertension by oral administration of its hydrogen tartrate. It can be estimated colorimetrically by coupling with methyl orange, or fluorimetrically by reaction with eosin in xylene, the limits of sensitivity being 0.5 mug./ml. and 0.001 mug./ml. respectively. These methods, combined with appropriate extraction techniques, were suitable for estimating pempidine in aqueous solutions of its salts, in biological fluids and the like, and for investigating the biochemical properties of the drug when given orally to rats in amounts similar to those used clinically.When administered orally to rats pempidine was rapidly absorbed, the maximum concentration in plasma being attained after 30 min. The drug was preferentially taken up by erythrocytes and a red cell/plasma partition ratio of about 1.2 established with clinical doses. Pempidine was soon distributed throughout the body, including the cerebrospinal fluid, and the highest concentrations were found in kidney, spleen and liver. Pempidine also entered the foetus and passed thence into the amniotic fluid. Protein-binding of the drug occurred only to a very limited extent and there was little evidence that it was metabolized. Pempidine was excreted rapidly in urine during 24 hr. following oral administration.


Protection against lethal organophosphate poisoning by quaternary pyridine aldoximes. The effect of 18 pyridinium aldoximes on diethylphosphoryl-acetocholinesterase in vitro and the protection against lethal poisoning by ethyl pyrophosphate (TEPP) in mice pretreated with 0.095 m.mole/kg. of these oximes was investigated. Monoximes and dioximes of polymethylenebispyridinium compounds were studied in greater detail since they were up to 22 times more potent than pyridine-2-aldoxime methiodide (2-hydroxyiminomethyl-N-methylpyridinium iodide) in reactivating diethylphosphoryl-acetocholinesterase in vitro and protected mice against lethal poisoning by up to 15 LD100 of ethyl pyrophosphate. These oximes were also up to 52 times more potent than pyridine-2-aldoxime methiodide in reactivating di-isopropylphosphoryl-acetocholinesterase in vitro and were effective in preventing lethal poisoning by dyflos (di-isopropyl phosphorofluoridate). The antidotal action against diethyl phosphostigmine (Ro 3-0340) was even greater than that against ethyl pyrophosphate. Some of the most effective oximes had antidotal actions in poisoning by ethyl pyrophosphate, diethyl phosphostigmine and dyflos when given in 0.0095 m.mole/kg. and this effect was enhanced by 1 mg./kg. atropine sulphate. In vivo reactivation of diethylphosphoryl-acetocholinesterases by 0.0095 or 0.095 m.mole/kg. of oximes of polymethylenebispyridinium compounds was demonstrated in blood but not in brain. Atropine-like and neuromuscular blocking activities were studied on isolated organs and protection against lethal doses of neostigmine and related anticholinesterases were also investigated. Some of the oximes of polymethylenebispyridinium compounds have, relative to pyridine-2-aldoxime methiodide, a higher therapeutic ratio in mice and considerably greater water-solubility. The possible advantages to be gained from their use in preference to pyridine-2-aldoxime methiodide are discussed.


The effect of morphine on vagal inhibition of the heart. The action of morphine (0.1 to 100 mg./kg.) on the cardiac slowing produced by stimulation of the right vagus nerve varied in the four species investigated. In the guinea-pig, morphine had no inhibitory effect and in the cat the effect was small, but in the rat and the rabbit stimulation of the vagus slowed the heart much less after administration of morphine than before. Further, in the last two species morphine delayed the onset of cardiac slowing. Nalorphine, which given alone had a slight morphine-like action, partly reversed the effect of morphine.


The stability of endogenous corticotrophin in rat blood in vitro. Endogenous corticotrophin is stable in blood in vitro for periods of up to 1 hr. at 4 degrees and 22 degrees , and in plasma for at least 24 hr. at -15 degrees . Estimates of plasma corticotrophin concentration provide less consistent results than assays done on whole blood. The optimal conditions for storing blood prior to the determination of its corticotrophin concentration are discussed.


The effects of sodium salicylate on the oxygen consumption of rats. The effects of sodium salicylate on oxygen consumption of intact rats and rats treated with tubocurarine have been studied. Intraperitoneal injections of sodium salicylate in untreated rats produced varying results which depended on both the dose and the concentration used. Intravenous injections in rats treated with curare gave rise to an increase in oxygen consumption which was proportional to the log dose over a range of 0.0625 mg./g. to 0.5 mg./g. body weight. It was concluded that sodium salicylate stimulated the oxygen consumption of rats when the concentration of the drug in the plasma was high.


The effect of treatment with a large dose of isoniazid on an established tuberculous infection in mice. Mice were infected intracorneally with Mycobacterium tuberculosis var. bovis and the infection allowed to develop for a period of 2 weeks. At this stage the animals were divided into two main groups; one received no treatment, the other was treated with large doses of isoniazid (3.0 mg./mouse/day). The effect of treatment on the primary lesion, the viability of the bacilli, the systemic spread of infection, and the production of immunity were observed. Treatment was continued for 11 months, after which the animals were observed for another 8 months. Within a few days of starting isoniazid treatment the primary lesion stopped increasing in size, regressed slightly and stabilized at a size of about one-third of that of the controls. There was little evidence of any clearing of the bacilli from the lesions; they remained strongly acid-fast and morphologically normal for many months after infection, although by 13 months about half of the organisms in both groups had become very granular. The evidence suggests that in control and treated animals the bacilli in the cornea had usually all died within 8 months after infection. In two treated corneas, living virulent bacilli were demonstrated 15 months after inoculation. In the untreated animals, the disease spread systemically to involve the lungs, liver, and spleen, and by one year after inoculation the systemic tuberculous infection was very heavy, though not enough to kill the animals. The lesions in these animals contained many acid-fast bacilli. In the treated group, systemic spread of infection as judged by the development of small macroscopic lung foci was slight; acid-fast bacilli were found in only one animal. In the treated animals, practically no immunity could be detected 5 months after inoculation and had not reappeared 2 months after cessation of treatment; in the untreated animals immunity was present.


Supersensitivity due to prolonged administration of ganglion-blocking compounds. Repeated subcutaneous injections of ganglionic blocking agents in cats were found to cause a supersensitivity towards adrenaline in the submaxillary gland and the nictitating membrane. The supersensitivity resembled that produced by preganglionic denervation, namely section of the chorda tympani in the case of the gland and of the cervical sympathetic trunk in the case of the membrane. The blocking compounds used were chlorisondamine chloride and hexamethonium. With the former, the sensitization could be obtained in the normally innervated structures. When hexamethonium was used, however, the effect on the gland could be produced only if the synapse had been made particularly susceptible to the blocking action of this agent; this was achieved by cross-suture experiments.


Effects of cross-suture and of injected acetylcholine on the supersensitivity of denervated striated muscle. The sensitivity of the tongue muscles to acetylcholine was examined in repeated experiments on cats anaesthetized with hexobarbitone. The supersensitivity which developed after section of the hypoglossal nerve was found to decrease when the muscles, after cross-suture, became re-innervated from the vagus or the chorda-lingual nerve. The supersensitivity caused by denervation could also be reduced by injecting acetylcholine repeatedly during six hours in acute experiments.


Nicotine and the effect of antisympathomimetic agents on the aorta of the rabbit. The responses of strips of rabbit aorta to almost maximal doses of nicotine were less readily antagonized by five antisympathomimetic agents than were comparable responses to noradrenaline. The effect was most marked with dibenamine, ergotamine, and tolazoline: approximately twice the dose of noradrenaline was required to match the test dose of nicotine after treatment with the antagonists. Dose/response curves for nicotine before and after phentolamine 10(-7) indicate that the phenomenon may be reversed with low doses of nicotine and that the release of noradrenaline by nicotine within the tissues is probably a graded response. The pattern of nicotine/phentolamine antagonism in this preparation is consistent with the view that nicotine acts indirectly by releasing a noradrenaline-like substance, and the difficulty found in antagonizing responses to nicotine with antisympathomimetic agents is probably similar to that responsible for failure of atropine to block some parasympathomimetic responses to nicotine.


Central effects produced by injection of 48/80 into the cerebral ventricles of mice. Injections of 20 to 30 mug. of 48/80 into the cerebral ventricular spaces of mice produced a condition of motor excitement termed "delirium ambulatorium." This condition was aggravated by previous intraperitoneal injection of tranquillizers, atropine, and promethazine, not affected by previous injection of mepyramine and abolished by a previous injection of pentobarbitone. When an intraperitoneal injection of strychnine was followed by an intraventricular injection of 48/80, the strychnine convulsions became more violent, but the pattern of delirium ambulatorium was not produced.


Pharmacological methods of estimating inhibition of drug oxidation in the mouse. Three pharmacological techniques for measuring inhibition of "non-specific" oxidase activity in the mouse are described: (1) potentiation of pentobarbitone hypnosis, (2) potentiation of chlorpromazine hypothermia; and (3) reduction in the toxicity of octamethylpyrophosphorodiamide (schradan). Iproniazid, isoniazid, and beta-diethylaminoethyl 3,3-diphenylpropylacetate (SKF 525A) gave comparable results in all three tests.


Cardiovascular effects of intravenous infusions of 5-hydroxytryptamine in man. Intravenous infusions of 5-hydroxytryptamine creatinine sulphate in doses of 1,2, and 3 mg./min. of the salt into 42 normal subjects caused a dilator response of the forearm vessels, consisting of an initial transient increase in flow usually followed by a smaller but sustained increase. A fall in forearm flow was not seen. Heart rate was invariably increased and the increase preceded other changes by 10 to 20 sec. suggesting a direct effect on the heart. The sustained increase in flow probably represents a balance between the direct constrictor action of the drug and a secondary dilator effect. The blood pressure response was variable and it appeared unlikely that it was responsible for more than a small part of the forearm flow changes. Two subjects appeared to be abnormally sensitive to the drug.


Specificity of amine oxidase for optically active substrates and inhibitors. A number of optically active amines have been tested as substrates or inhibitors of amine oxidase of rabbit and guinea-pig liver. The two stereoisomers of beta-hydroxyphenethylamine were oxidized at the same rate by rabbit liver, but the guinea-pig liver extracts oxidized the D form more rapidly than the L form. The two stereoisomers of amphetamine were equally active as inhibitors of the rabbit liver oxidase, but with guinea-pig liver extracts dexamphetamine, the (+) form, was more potent as an inhibitor. In both species, 2-hydroxy-1-phenylethylamine was a weaker inhibitor than 1-phenylethylamine; in the rabbit liver (+) forms of these two amines were more potent as inhibitors.


Thiopentone and buthalitone: the relationship between depth of anaesthesia, plasma concentration and plasma protein binding. For 24 hr. after intravenous administration of buthalitone or thiopentone, plasma concentrations in young human subjects have been followed. Buthalitone was distributed to the tissues more rapidly but was metabolized at a slower rate than thiopentone. The relationships between these findings and differences in plasma protein binding and oil/water partition coefficients were studied. It is suggested that some of the differences observed in potency between the substances is a reflection of differences in their modes of distribution. No relationship was found between speed of recovery from anaesthesia and plasma barbiturate concentrations.


Actions of some analogues of 5-hydroxytryptamine on the isolated rat uterus and the rat fundus strip preparations. The search for substances which antagonize 5-hydroxytryptamine, and for those which act like it, has been extended to cover 5-substituted indoles which are analogues of 5-hydroxytryptamine, rather than analogues of tryptamine like the compounds previously studied by us. The isolated rat uterus and rat fundus strip preparations have been used to determine activity. The relationships between structure and activity of the compounds studied were not the same on the two preparations nor were they the same from one homologous series to another. These differences may be partly explained by the presence of amine oxidase in the rat fundus, as Vane (1959) has suggested, and by supposing that it is absent from the rat uterus. None of the compounds had marked antagonist activity. The most active antagonist on the rat uterus was 3-(2-aminopropyl)-5-benzyloxyindole, but this was less potent than 5-benzyloxygramine. On the rat fundus strip, however, the only antagonist, 5-benzyloxy-3-(2-dimethylaminoethyl)indole, was more active than 5-benzyloxygramine. On both preparations the most active stimulant was 3-(2-aminopropyl)-5-benzyloxyindole, which was about half as potent as 5-hydroxytryptamine. The next most active were 3-(2-aminopropyl)-5-methoxyindole and bufotenine.


Paraldehyde and methylpentynol and ganglionic transmission. Paraldehyde and methylpentynol blocked transmission of nerve impulses through the superior cervical ganglion of the cat when the drugs were administered intra-arterially to the ganglion or intravenously using the nictitating membrane as an indicator. Electrical studies showed that concentrations of methylpentynol and paraldehyde which blocked transmission in the isolated rat superior cervical ganglion were without action on the preganglionic nerve fibre. In amounts which blocked transmission in the isolated rat ganglion, paraldehyde had no depolarizing activity directly on the ganglion cells and did not interfere with the depolarizing activity of added acetylcholine. The results suggest that the block in transmission of the impulse could be accounted for by a decrease in the release of acetylcholine from the preganglionic nerve terminals. In both species the block was reversible.


Uptake of injected [14C] adrenaline in denervated and in normally innervated submaxillary glands of the cat. Radioactive adrenaline was injected into cats after one submaxillary gland had been denervated, either by section of the chorda-lingual nerve or by excision of the superior cervical ganglion. No indication was found that the supersensitivity caused by denervation was due to a greater uptake of adrenaline in the denervated gland. Stimulation of the chorda tympani greatly increased the amounts of radioactive adrenaline taken up by normally innervated submaxillary glands.


Pharmacology of methylpentynol and methylpentynol carbamate. The pharmacology of methylpentynol and methylpentynol carbamate has been studied. The drugs depressed monosynaptic and polysynaptic reflexes, and exerted weak ganglion and neuromuscular blocking actions. They also produced transitory hypotension, and increase of aortic blood flow. Perfusion of the coronary arteries with these drugs led to slowing of the heart, diminished systolic amplitude, dysrhythmias, and increased coronary flow. Respiration was stimulated with small and depressed with larger doses of both drugs. The two compounds diminished the response of the isolated guinea-pig ileum to drugs acting directly on muscle or through ganglia. The effect of the two substances was likened to that of other central nervous system depressants, particularly to that of ethanol.


The effect of methylpentynol and methylpentynol carbamate on the perfused superior cervical ganglion of the cat. The action of methylpentynol and methylpentynol carbamate on the perfused superior cervical ganglion of the cat was analysed. Both drugs, in doses of 1 to 5 mg., depressed the output of acetylcholine. If the acetylcholine output was reduced by more than about 50%, transmission failed. Both drugs also reduced the response of the ganglion to injected acetylcholine. The carbamate, but not methylpentynol itself, had a transient stimulant action on the ganglion, unaccompanied by acetylcholine release.


Binocular refraction; a simplified clinical routine.


Some heterozygous manifestations of colour blindness.


The effect of adrenal steroids and corticotrophin on the growth of a sarcoma of human origin in small laboratory animals. 9alphaFluorohydrocortisone, prednisolone, and hydrocortisone promoted the growth of the human tumour (H.S.l) in weanling rats, but deoxycortone acetate was ineffective even when injected in very high dosage; Cortrophin ZN, a long-acting corticotrophin preparation, was just as effective as cortisone. This effect of corticotrophin on tumour growth was mediated by the adrenal cortex, and was related to the enhanced secretion of adrenocorticoids; some correlation existed between tumour size and adrenal hypertrophy in the corticotrophin-treated rats. The action of adrenal steroids and of corticotrophin in promoting the growth of the tumour is discussed.


Some notes on haptic lenses.

Some notes on haptic lenses.


Incidence of disease and disability in elderly men.


Contributions and demands of elderly men.


Observations on the growth and maturation of Indian boys in Durban, South Africa.


Incapacity for work among the insured population of Great Britain.


Sex pattern of admissions to mental hospitals in relation to social circumstances.


Simple methods in the diagnosis of congenital heart disease.


Radiological evaluation of the pelvic outlet.


Malignant disease of the antrum.

Malignant disease of the antrum.


The effect of x irradiation on the diffuse activity performance of rats, guinea pigs and hamsters.


Calvé's disease: does it exist? The question of its aetiology.


The effect of irradiation on fertility of the male rat.


Pouch formation of the gastric fundus as a radiological sign of carcinoma of the cardia.


The energy and quantum equivalent of the röntgen.


Instrumental behaviour of albino rats in response to incident x radiation.


Multiple cobalt 60 sources for treatment of carcinoma of the body of the uterus.


Measurements of the parallactic unsharpness caused by the thickness of the film and the intensifying screens in radiography.


A compensator for variations in tissue thickness for high energy beams.


Large-scale use of Sabin type 2 attenuated poliovirus vaccine in Singapore during a type 1 poliomyelitis epidemic.


British standard poliomyelitis antisera types 1, 2, and 3.


Action of chlorothiazide and oradon, alone and in combination.


Clinical evaluation of hydrochlorothiazide.


Hydrochlorothiazide, a new oral diuretic.


Periarthritis of the shoulder: a study of the disease and its treatment.


Tracheo-bronchial and pulmonary chondro-adenoma (hamartoma).


A case of rheumatoid arthritis with ankylosis of the crico-arytenoid joints.


RADIOIODINE in the treatment of thyrotoxicosis.


THE CHLOROTHIAZIDES and potassium.

THE CHLOROTHIAZIDES and potassium.


EXPERIMENTAL surgery.

EXPERIMENTAL surgery.


Principles of modern steroid therapy. I.


Cushingoid reaction to triamcinolone.

Cushingoid reaction to triamcinolone.


Skin disinfection.

Skin disinfection.


Facts of importance to the organization of a national health service from a five-year study of a general practice.


Aetiology of disseminated sclerosis.

Aetiology of disseminated sclerosis.


Action of prednisone in insulin-resistant diabetes.


Chemotherapy of non-tuberculous pulmonary infections.


Chemotherapy of pulmonary tuberculosis.

Chemotherapy of pulmonary tuberculosis.


The natural history of cerebrovascular disease.


SINGAPORE trial of live poliomyelitis vaccine.


Principles of modern steroid therapy. II.


GRANTLY DICK-READ.

GRANTLY DICK-READ.


An experiment in mass radiography.

An experiment in mass radiography.


Puerperal cardiomyopathy.

Puerperal cardiomyopathy.


Acute bacillary dysentery in Cyprus; a comparative study of treatment in 332 cases.


Sulphonamides and streptomycin in bacillary dysentery; a controlled trial.


Survival after cardiac arrest.

Survival after cardiac arrest.


THE INDWELLING catheter and urinary sepsis.


TREATMENT of bacillary dysentery.

TREATMENT of bacillary dysentery.


THE SOMATIC mutation hypothesis of cancer.


PHTHISIS and pregnancy.

PHTHISIS and pregnancy.


JOHN REID.

JOHN REID.


The scientific approach to surgery.

The scientific approach to surgery.


Acquisition of a B-like antigen by red blood cells.


A weak B antigen, probably acquired.

A weak B antigen, probably acquired.


Intestinal diverticula.

Intestinal diverticula.


Heparin-like anticoagulant occurring in association with chronic nephritis.


Immediate sensitivity reaction to poliomyelitis vaccine.


JERKS on falling asleep.

JERKS on falling asleep.


Medical advisory committees in mental hospitals.


Antacids and allied drugs.

Antacids and allied drugs.


Rapidly acting thyroid hormones and their cardiac action.


Pseudo B: an acquired group antigen.

Pseudo B: an acquired group antigen.


Massive jejunal diverticulosis with steatorrhoea and megaloblastic anaemia improved by excision of diverticula.


Purpura in kwashiorkor.

Purpura in kwashiorkor.


VITAMINS in blood formation.

VITAMINS in blood formation.


DELIVERY by suction.

DELIVERY by suction.


ERGOTAMINE treatment of migraine.

ERGOTAMINE treatment of migraine.


Diabetes in the tropics.

Diabetes in the tropics.


Gorman Diagnostic and Research Building.


Rehabilitation in medicine at Georgetown University Medical Center.


Electromyography.

Electromyography.


Rheumatoid arthritis: viral studies of adult human synovial fluid and tissue using tissue culture techniques.


A classification of glomerular diseases.


Portraits of Georgetown.

Portraits of Georgetown.


The tissue committee proves its worth.

The tissue committee proves its worth.


Some clinical and physiologic aspects of angina pectoris.


Movements of the heart and velocity of pressure change during the first part of systole.


Genetic factors in predisposition to pernicious anemia.


Bellevue Hospital: the scene of telecasts at Congress.


Pietro Pisani and the mental hospital of Palerino in the early 19th century.


Psychophysiological research methods.

Psychophysiological research methods.


The effect of intestinal motility on the formation of adhesions.


Harvey and the circulation of the blood in America during the colonial period.


Variability of cholesterol levels in individual Johns Hopkins medical students, with observations on stopping smoking, vitamin B12 administration and acute infection.


The art of taking a neurological history; extraction of history and re-enactment.


Multiple sclerosis as an incidental complication of a disorder of lipid metabolism. I. Close resemblance of the lesions resulting from fat embolism to the plaques of multiple sclerosis.


Multiple sclerosis as an incidental complication of a disorder of lipid metabolism. II. A survey of the geographical, clinical and biochemical evidence; the significance of endogenous fat embolism.


Multiple sclerosis as an incidental complication of a disorder of lipid metabolism. III. Treatment with heparin of acute exacerbations of the disease.


Walter Reed, C. Finlay, and their predecessors around 1800.


Problems in the differential diagnosis of peripheral nerve lesions; the disconcerting effects of multiple independent disorders of the nervous and muscular systems.


Gastrointestinal lesions associated with organic brain disease; review of the literature and presentation of a case.


The development of physiology in the last fifty years.


Microscopic physiology since 1908.

Microscopic physiology since 1908.


Effects of diodrast on the pial circulation; complications of carotid angiography.


Historical mindedness in medicine.

Historical mindedness in medicine.


A note on Breuer's hypnoidal theory of neurosis.


Ego autonomy in psychiatric practice.

Ego autonomy in psychiatric practice.


The L. E. cell and the L. E. serum factors.


The expanding pattern of the inborn errors of metabolism.


Phenylketonuria and maple sugar urine disease.


Gilbert's disease.

Gilbert's disease.


Drug-induced hemolytic anemias and congenital galactosemia: examples of genetically determined defects in erythrocyte metabolism.


Men, medicine, and cells.

Men, medicine, and cells.


Valentine Mott, 1785-1865; the Academy's third president.


[Albopapuloid form of congenital epidermolysis bullosa; associated dental & ungual dystrophy].


Iso-antigens.

Iso-antigens.


Some recent data on the H-2 system of mice.


Antigen and antibody in transplantation immunity: some problems of investigation.


Some problems of induction of transplantation tolerance.


Skin transplantation immunity in relation to hypersensitivity reactions of the delayed type.


Evidence of adaptation in homografts of normal tissue.


[Mucopolysaccharides in a case of myoepithelioma; physiopathogenic mechanisms].


Transplantation immunity and immunological tolerance and the study of antigenicity of tissues and their derivatives.


Prolonged survival of skin homografts in adults.


Ovarian transplantation in mice.

Ovarian transplantation in mice.


Diversity of transplantation antigens in the mouse.


The immunity-inhibiting role of the spleen and the effect of dosage and route of antigen administration in a homograft reaction.


Studies on the runting syndrome in newborn mice.


Some reactions observed with transplanted reticuloendothelial cells in mice.


Homologous disease in unirradiated F1 hybrid mice receiving parental lymphoid tissue.


The graft versus host assay in transplantation chimaeras.


Blood transfusion in fowl: an example of immunological tolerance requiring the persistence of antigen.


Erythrocyte repopulation after transplantation of homologous erythropoietic tissues into irradiated mice.


Grafting rat skin to mouse rat chimaeras.


The pathogenesis of the secondary disease following foreign bone marrow transplantation in irradiated mice.


[Effect of amphomycin on the experimental infection of mice by Trypanosoma rhodesiense].


[Pathogenic E. coli].

[Pathogenic E. coli].


[Chiasmatic syndrome in pregnancy (cerebral tumor)].


Cushing's syndrome: a clinical study of 15 cases.


Problems associated with plaque formation by herpes simplex virus in monolayer cultures of HeLa cells.


Phenylpyruvic oligophrenia.

Phenylpyruvic oligophrenia.


The treatment of chronic discoid lupus erythematosus with antimalarial drugs.


Baron Guillaume Dupuytren and the palmar contracture that bears his name.


Subtotal gastric resection; an appraisal of a means of treatment of benign peptic ulceration of the stomach and duodenum. In a series of 400 cases of subtotal gastric resection for the treatment of benign ulceration of the stomach and duodenum, the mortality, morbidity and recurrence rate was acceptably low. Fifty-six per cent of the patients had a perfect result, 38 per cent satisfactory, and 6 per cent unsatisfactory. However, the postoperative nutritional status was sufficiently interfered with in a number of patients whose preoperative weight was subnormal that the routine adoption of 75 per cent gastric resection must be questioned. Vagotomy with either pyloroplasty or partial resection may prove to be the most valuable procedure for patients of this type. In properly selected patients, however, gastric resection is a rewarding procedure for both patient and surgeon.


Studies on the presence of virus in fat tissue of two fatal cases of poliomyelitis.


Privileged communications; physician-patient confidences in California.


The work of an Rh committee; experiences in a private general hospital. An Rh committee was formed at Saint John's Hospital in Santa Monica to provide preadmission consultation on all potential Rh and ABO problems and to maintain a file of information on Rh-negative patients in the delivery room. It is urged that no patient go to the delivery room without the known Rh-ABO type as part of the labor record. All obstetrical patients at the hospital are given "obstetrical information cards" for use as a memorandum on the labor record. A pink card identifies the Rh-negative patient. The program keeps the staff "Rh-conscious" and has improved teamwork among the obstetricians, pediatricians, nurses and the laboratory.


Visualization of the biliary tract; preoperative and post-operative radiologic investigation. Modern operative treatment of diseases of the bile passages requires the use of x-ray visualization of the biliary tract before, after and during operation. Nearly every surgeon uses x-ray study of the biliary tract before operation and it is widespread practice to carry out such study after operations in which a tube has been placed in the bile passages. However, there is a remarkable aversion to operative cholangiography.The usual reasons for avoiding operative cholangiography are unfamiliarity, inertia, concern over complications of the technique, and the feeling that it is unnecessary or wasteful of surgeon's time and patient's money. Yet the results of operative cholangiograms compare favorably with those obtained with the more customary x-ray studies of the bile ducts carried out after operation, at a time when the information gained is much less valuable in avoiding additional operations and in contributing to a smooth and rapid convalescence.


Periodic medical examinations; disease detection and health promotion. The medical examination of persons who have no medical complaints is a procedure that has different purposes than the traditional diagnostic examination. These include not only the detection of incipient disease but the evaluation of the adjustment of the individual to his environment and an assessment of his personal hygiene. It should be concluded by a discussion of what has been found, and by positive, persuasive advice and education which will lead to better health. Interest in such work and competence for it are not found in every physician. Physicians who do not want to acquire such competences should recognize the fact and refer such work to others who are prepared to cope with it. Inept, incomplete health examinations disappoint the patient and make the physician uncomfortable; thorough, constructive examination and counseling is satisfying and profitable to both.


Prevention of occupational cancer hazards.


Nonsurgical treatment of convergent strabismus. It is generally agreed that surgical treatment of convergent strabismus should be withheld until all other less traumatic approaches have proved ineffectual. There are four categories of nonsurgical treatment. One is psychiatric. Too often psychiatric problems in the causation of convergent strabismus are either overlooked or unrecognized. Another is the proper employment of optical devices. For example, spectacle lenses to eliminate the need for excessive accommodation with its associated convergence excess, and the employment of prisms in the lenses to permit the two eyes to see as a unit even though they may not be properly anatomically oriented. Another kind of treatment is orthoptics, the use of exercises and rather complex optical equipment in a laboratory to train the patient in coordination between the two eyes. Treatment with drugs is based on the fact that certain drugs reduce the effort necessary for accommodation (much as eye-glasses do) and therefore lessen the stimulus toward convergence which may possibly tend toward the development of convergent strabismus.


You are standing at the bedside of a patient dying of untreatable cancer.


Surgical treatment of convergent strabismus. In convergent strabismus, glasses, visual training and exercises are often helpful, but operation is usually needed in addition to produce a functional or cosmetic cure. Babies who are born cross-eyed should be examined early and nonsurgical treatment started so that proper visual appreciation will be developed in both eyes. Children in whom strabismus develops some time after birth (usually between 18 months and six years of age) should be examined with atropine, glasses prescribed when indicated and full medical treatment instituted. If those measures fail, operation should be done on one or both eyes, the operation depending on the magnitude of the deviation.


Electromyography in strabismus.

Electromyography in strabismus. Electromyography of the human extraocular muscles is a new research tool designed to elucidate many problems in ocular physiology. Although at present it affords little clinical help in the diagnosis and treatment of strabismus, it may in time be of value in neuro-ophthalmologic disease.


Case report: cystosarcoma phyllodes.

Case report: cystosarcoma phyllodes.


Cardiac arrest through volition.

Cardiac arrest through volition.


Book services for the physician.

Book services for the physician.


Acute renal failure manifesting as water- and salt-losing insufficiency.


Alson R. Kilgore.

Alson R. Kilgore.


Newer drug treatment in dermatology.

Newer drug treatment in dermatology. This article deals with a number of newer drugs now being employed in dermatology. The great beneficial role of corticoids both topically and systematically for various inflammatory dermatoses is now amply proved. The addition of a corticoid to a conventional acne lotion renders it much more effective. Nystatin for monilial infections is especially effective in a powder form. For systemic use Griseovulvin, now becoming available, is the most interesting current development in dermatology. Presumably, it is highly effective against ringworm of the hair, nails and skin. The role of synthetic antimalarials in treating chronic discoid lupus erythematosus and light sensitivity eruptions also is firmly established.


Cardiac operations with extracorporeal circulation. In a series of 50 patients for whom a heart-lung machine was used for periods as long as 70 minutes during operations to correct structural defects of the heart, there were no deaths attributable to the machine. Seven patients died. Two of them had high pressure ventricular septal defects with bidirectional shunts; a third patient with the same lesion recovered after repair. One patient died of cardiac tamponade when a large blood clot formed about the entire heart in a loosely closed pericardial sac. Others died of various causes. The development of subacute bacterial endocarditis in one patient led to a change in sterilization of apparatus.


Injuries of the hand and forearm; treatment of damaged soft tissues. Successful primary repair of soft tissue injuries of the hand and forearm holds the ultimate disability to a minimum. The kinds of trauma and the resultant soft tissue damage may be classified. Attention to details and technique in carrying out the primary reparative operation on the injured hand largely obviates a crippling deformity or the need for much reconstruction later.


Tuberculosis; recent trends in infection, disease and deaths in California. Although fewer patients with tuberculosis are reported in a far advanced stage of the disease than ever before, the proportion of persons dying of tuberculosis whose disease had not previously been diagnosed appears to be increasing. The average length of sanatorium treatment, and the intramural case fatality rates have not shown much decrease. Tuberculosis mortality rates fall during economic depressions and rise with business booms. Epidemics of influenza do not always increase tuberculosis death rates. Common claims to the contrary are not sustained by recent California data.


Dermatologic changes in the circumileostomy skin. A comprehensive questionnaire inquiring about difficulties with care of the skin in the area immediately surrounding the artificial anus was sent to ileostomy patients in the United States. Eighty per cent of 327 replying to the questionnaire had such difficulties. The problem of irritation is essentially that of intimate contact of fecal material with the circumileostomy skin, and associated factors are the potentially irritating materials used in the manufacture of ileostomy appliances, as well as the adhesives used to affix the appliance to the skin. Mechanical trauma incident to removal and reapplication of the appliance, as well as loosening of the disc and exposure of unprotected skin, accelerates the corrosive action of the material discharged. Changing the appliance before leakage or irritation occurs is helpful in preventing skin difficulties.In cases of long standing or repeated irritation, care must be taken to check the suitability of the appliance or the possibility of a complication in the stoma that could be corrected surgically.


Ultrasound; its effect on the cardiovascular system when applied over the carotid sinus and stellate ganglion. In a study of 29 patients to observe untoward reactions to applications of ultrasound over the carotid sinus and stellate ganglion areas, it was noted that cough was evoked in five patients, premature ventricular systoles in three and a burning sensation of the skin at the point of treatment in five. No considerable effect on heart rate or blood pressure was observed.


Medial epicondylitis.

Medial epicondylitis.


Stretching of the sciatic nerve; a means of relieving postoperative pain following removal of ruptured lumbar intervertebral discs. Stretching the sciatic nerve for the relief of "sciatica" was frequently employed before 1900 and was subsequently abandoned, probably because it was done without sufficient scrutiny of the indications. The procedure has recently been employed in cases in which "sciatica" remains following the operative removal of ruptured intervertebral discs, and it has been instrumental in relieving postoperative "sciatica" when the cause was the formation of adhesions about the lumbar nerve roots. If the nerve root is compressed by recurrent disc protrusion or by adjacent bone, the manipulation usually increases the pain, a phenomenon that has been helpful from a diagnostic standpoint.


Food hypersensitivity; correlation of intradermal skin tests with clinical allergenicity. A study was made to determine how well the results of skin tests for sensitivity to various foods agreed with observation of clinical reactions to those foods. Test reactions were divided into several categories-negative, and 1, 2, 3 or 4 plus. Then the strong reactions, that is the 3 and 4 plus reactions, the milder reactions and the negative results were studied separately to determine the agreement of results, in each category, with the clinical response. Wide variations were noted. For some foods the agreement was high, for others low. For some foods, the agreement was high in some categories of reaction, low in others. For example, negative results of skin test might match with nonreaction to the food clinically in a high proportion of cases, and 3 or 4 plus reaction to skin test might be in close agreement with the incidence of distress upon ingestion of the food, yet for the same food there might be very poor correlation between mild reaction to skin test and clinical response. This being the case, accuracy of skin tests cannot be determined simply by combining all data on reactions, of whatever degree, and taking the aggregate of agreement in all categories as an index of the validity of the test. Each category of reaction must be considered separately.Combined data and categorized data on accuracy of skin tests for sensitivity to 26 foods were tabulated in the present study.


Tracheotomy in a case of tracheobronchitis secondary to influenza.


Adenocarcinoma of the rectum with metastasis to the nail-bed of the finger.


Laceration of the profunda femoris artery complicating fracture of the shaft of the femur.


Artificial respiration and respirators.

Artificial respiration and respirators.


The practical value of the electroencephalogram during anaesthesia.


The selection of a mechanical ventilator.


Electroencephalographic warning of impending localized cerebral disorder during anaesthesia.


The effect of perhenazine on epinephrine-induced cardiac arrhythmias in dogs. I. Anaesthesia with fluothane, and fluothane-ether azeotrope.


A clinical evaluation of levomepromazine in anaesthesia.


The effect of perphenazine on epinephrine-induced cardiac arrhythmias in dogs. II. Anaesthesia with cyclopropane, chloroform, and trichlorethylene.


Changes in the electrocardiogram during induction of anaesthesia and endotracheal intubation.


The effect of halothane on the liver of dogs exposed to mild hypoxia.


Ritalin (methylphenidate): clinical experiences.


An aid to general anaesthesia for bronchograms.


Frederick Arthur Harvey Wilkinson.

Frederick Arthur Harvey Wilkinson.


Vagus and glossopharyngeal nerve paralysis: case report.


Progress report on Canada's hospital insurance program.


What's the difference.

What's the difference.


Double harness.

Double harness.


Your president reports to the 15th biennial meeting of the Canadian Hospital Association.


You and your association.

You and your association.


A new era; a new way.

A new era; a new way.


Food preservation by irradiation.

Food preservation by irradiation.


Effect of erucic acid on incorporation of acetate-1-C14 into cholesterol and faty acids.


Histological evidence for cellular adaptation to non-freezing cold injury.


Freezing damage to bovine cream indicated by release of enzymes.


Effect of melanophore-stimulating hormone on human dark adaptation.


The fractionation of the histones of calf thymus and chicken erythrocytes by cation-exchange chromatography with sodium salts.


A surface tension equilibrium study of human serum in atherosclerosis.


Inhibition of carbohydrate metabolism of rat brain tissue by adrenochrome.


The effect of phenethylbiguanide upon the metabolism of the isolated rat diaphragm.


The interconversion of glycine and serine in Zea mays.


Studies of phloridzin in Malus.

Studies of phloridzin in Malus.


Inhibition of the esteratic activity of thrombin by sarin and tabun.


The use of the HeLa cell tissue cultures and adenovirus complement fixation test in search of a cause of appendicitis.


The effect of storage upon the blood group antigens, P, c, K, and Fya.


A review and study of water-soluble polyethylene glycols as a routine embedding medium.


Neomycin as a selective agent in culture media.


Construction and use of an inexpensive apparatus for filter paper electrophoresis.


Canadian pilot study in music therapy with muscular dystrophy children.


The occupational therapy assistants' course.


Group activities for the O. T.

Group activities for the O. T.


Paralytic poliomyelitis trends, 1957.

Paralytic poliomyelitis trends, 1957.


The Newfoundland Department of health.

The Newfoundland Department of health.


Trends in the epidemiology and treatment of tuberculosis.


Hospital home care in a metropolitan area.


The relationship between public health education and school health education and school health education.


Report of an outbreak of Bornholm disease, with isolation of Coxsackie B5 virus: Toronto, 1958.


The Nova Scotia Department of Public Health.


Illness as seen by the patient and by the physician.


Visual aids in public health education.

Visual aids in public health education.


The recognition and management of traumatic ruptures of the tracheo-bronchial tree.


THE ORGANIZING committee of the Canadian Public Health Association, 1910: Maurice Macdonald Seymour, 1857-1929.


Surgical treatment of achalasia of the oesophagus.


Cysts and cystic tumours of the anterior mediastinum.


The recovery of tumour cells from venous blood draining cerebral gliomas; a preliminary report.


The effects of gradual complete occlusion of the hepatic veins.


An experimental study of tendon suturing techniques.


Acute and chronic breast abscess.

Acute and chronic breast abscess.


An evaluation of aseptic and antiseptic techniques as practised in a modern hospital. II. Surgical wards and dressing stations.


Replacement of a segment of the common bile duct by an lvalon prosthesis in dogs.


Gastric polyps.

Gastric polyps.


Small bowel obstruction: a review of operative cases from the Royal Alexandra Hospital, Edmonton, 1953-1957.


New instruments for sympathectomies.

New instruments for sympathectomies.


Intra-atrial myxoma; review of literature and report of a right atrial myxoma diagnosed preoperatively and successfully treated.


Dupuytren's contracture: heredity as an etiological factor.


Retroperitoneal lipoma causing renal displacement.


The cytological diagnosis of solid tumours by small needle aspiration and its influence on cancer clinic practice.


Rehabilitation; home program.

Rehabilitation; home program.


Sudden unexpected death in infants.

Sudden unexpected death in infants.


The systolic murmur in mitral stenosis.

The systolic murmur in mitral stenosis.


Experience with serum glutamic oxaloacetic transaminase.


The elderly primipara.

The elderly primipara.


Intravenous and oral trial of stilboestrol diphosphate in prostatic carcinoma.


Haemorrhoids; their treatment in the acute stage.


Trimeprazine, a new phenothiazine derivative for treatment of pruritic dermatoses.


Term labour: its facilitation by relaxin; a preliminary report.


The inheritance of diabetes mellitus.

The inheritance of diabetes mellitus.


Impressions of a common psychiatric entity.


Pneumatosis cystoides intestinalis; a report of two cases in infants.


The need for additional rehabilitation facilities for arthritic patients in Canada.


Alexis St. Martin.

Alexis St. Martin.


Toxoplasmosis.

Toxoplasmosis.


F. ARTHUR H. WILKINSON.

F. ARTHUR H. WILKINSON.


The management of idiopathic thrombocytopenic purpura.


Studies of erythrocyts survival in acute leukaemia.


A comparison of the cephalin-cholesterol flocculation and thymol turbidity tests in patients with portal cirrhosis.


Myocardial nutrition after the ivalon sponge operation; the return of a 400 million year old system.


The use of intravenous methylphenidate (ritalin) in psychiatric interviewing.


Preliminary clinical study of dipipanone hydrochloride (pipadone) in anaesthesia.


Two thousand cases of fluothane anaesthesia.


Scurvy and its prevention by vitamin C fortified evaporated milk.


Fatal myocarditis complicating interstitial pneumonitis; a report of three cases.


Salicylate intoxication in the elderly.

Salicylate intoxication in the elderly.


An unusual introduction to practice.

An unusual introduction to practice.


70 mm. Spot film camera.

70 mm. Spot film camera.


Idiopathic hypoproteinaemia.

Idiopathic hypoproteinaemia.


Vaccination against poliomyelitis with attenuated live virus.


Poliomyelitis in Manitoba-1958.

Poliomyelitis in Manitoba-1958.


Seasonal aseptic meningitis caused by Coxsackie and ECHO viruses, Toronto, 1957.


Chlorothiazide in the prenatal outpatient: a study of its effect upon serum electrolytes.


Observations on the effect of potassium perchlorate on thyroid function.


Criteria for oral sustained release medication with particular reference to amphetamine.


Trifluoperazine in nausea and vomiting of pregnancy.


Toxicity of imipramine: report on serious side effects and massive overdosage.


Bisacodyl (dulcolax) in proctology.

Bisacodyl (dulcolax) in proctology.


Lymphangioma of the epididymis.

Lymphangioma of the epididymis.


Gastro-intestinal manifestations of hyperparathyroidism.


Neuromuscular paralysis and respiratory arrest caused by intrapleural neomycin.


Non-fatal cutaneous anthrax of obscure origin.


Combined intrauterine and extrauterine pregnancy.


The work of specialists and general practitioners in Ontario.


Trifluoperazine in treatment of the acutely ill psychotic; a preliminary report.


Massive transfusions and bleeding during surgery.


Apathetic hyperthyroidism.

Apathetic hyperthyroidism.


Dr. William Vernon Cone: 1897-1959.

Dr. William Vernon Cone: 1897-1959.


Dr. Pierre Masson.

Dr. Pierre Masson.


Dr. ALLAN COATS RANKIN.

Dr. ALLAN COATS RANKIN.


Hypertension in children.

Hypertension in children.


Solitary pulmonary nodule.

Solitary pulmonary nodule.


The crystallization of cervical mucus; a critical analysis based on clinical research.


Malabsorption syndrome following extensive resection of the small intestine.


A survey of duodenal ulcer; 724 cases.

A survey of duodenal ulcer; 724 cases.


A respiratory unit: the Toronto General Hospital unit for the treatment of severe respiratory insufficiency.


Experience with glipasol (R. P. 2259)-an antidiabetic sulfonamide drug.


Cysticercosis cerebri.

Cysticercosis cerebri.


Simulation of tetanus by trifluoperazine overdosage.


Acquired immunity in tuberculosis.

Acquired immunity in tuberculosis.


Isolation of a haemadsorption virus from the recent outbreak of respiratory illness in Ontario.


The control of acid in the duodenal ulcer patient.


Five years of progress.

Five years of progress.


This is Canada.

This is Canada.


The psychiatrist and the child.

The psychiatrist and the child.


The responsibilities of the public health nurse.


Jesse P. Greenstein. Frontispiece.

Jesse P. Greenstein. Frontispiece.


Psammoma bodies and thyroid cancer.

Psammoma bodies and thyroid cancer.


Dermatomyositis in cancer: a possible etiological mechanism.


Patterns of early invasion from intraepithelial carcinoma of the cervix.


The relation of bone marrow plasmacytosis to serum proteins in cancer patients.


The carcinogenic action of methylcholanthrene on mouse skin in organ culture.


Palliative interscapulothoracic amputation in the management of the breast cancer patient.


The significance of early treatment of breast cancer; changes correlated with the cancer education programs of 1940-1955.


An evaluation of pelvic exenteration for advanced carcinoma of the lower colon.


Relative incidence of malignant neoplasms in Thailand.


Growth of small compatible tumor implants in presence of admixed radiation-killed or incompatible tumor cells.


The malignancy of a cigarette tar carcinoma. VI. A description of 102 successive transplantations and of metastasis to lung and node.


Carcinoma of the bile ducts.

Carcinoma of the bile ducts.


Hormonal therapy in cancer of the breast. XIV. The effect of 19-nortestosterone propionate therapy on clinical course and hormonal excretion.


An experimental study of the effect of irradiation on the dissemination of cancer.


The relation of anticancer activity to chemical structure: a review.


Inflammation and prognosis in breast cancer; a search for host resistance.


Hormonal therapy of metastatic female breast carcinoma. I. 9 alpha-Bromo-11-ketoprogesterone.


Differential fluorescence staining of normal and neoplastic tissues: use of various serum proteins.


In vitro and in vivo inhibition of catalase by uric acid and other nucleic acid catabolites.


The fibrinolytic enzyme system in prostatic cancer.


Fractionation of azopeptides in tryptic digests of rat liver.


The relationship of tumor necrosis to white blood cell changes in the hamster.


The effect of a leukemia virus on phosphorus uptake by mouse spleen.


Cholangiolocellular carcinoma of the liver.


The hepatocarcinogenicity of tannic acid.


The effect of glucagon on tumor growth.

The effect of glucagon on tumor growth.


Chromatographic studies of purine metabolism. IV. Reversal of azaserine-induced inhibition by phenylalanine and tryptophan.


Comparison of the responses of normal, precancerous, and neoplastic mouse mammary tissues to hormones in vitro.


The effects of 5-fluorodeoxycytidine, 5-fluorodeoxyuridine, and related compounds on transplanted mouse leukemias.


Growth inhibition of a human tumor cell strain by 5-fluoro-2-deoxyuridine: time parameters for subsequent reversal by thymidine.


Mammary response to prolonged estrogenic stimulation in the monkey.


Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.


The histological distribution of arginase activity in solid mouse tumor transplants and a comparison with ascites tumors and normal tissues.


Killing effect of rat bone marrow in sublethally irradiated LAF mice.


Mechanism of growth. I. Interrelation between deoxyribonuclease and deoxyribonucleic acid synthesis in nonmalignant growth.


The cocarcinogenic-like effect of the growth-promoting factor of exudates.


Leukocyte alkaline phosphatase activity in hematopoietic disorders; a correlative study by biochemical and cytochemical techniques.


Prolonged survival in diffuse pleural mesothelioma treated with AU198.


Primary malignant lymphomas of the lung.


Studies on the pathogenesis of neoplasms by ionizing radiation. I. Pituitary tumors.


Antitumor activity of glucagon.

Antitumor activity of glucagon.


Combined nonmetastasizing fibrosarcoma and chromophobe tumor of the pituitary.


Cineangiocardiographic recordings of the cyclic changes in volume of the left ventricle.


Primary thrombosis of both renal arteries.


Survey procedures for the detection of asymptomatic tumors of the rectum and colon.


A topographic study of uterine epithelial atypia associated with chorionic tissue: demonstration of alteration in the endocervix.


The treatment of cancer, especially inoperable cancer, of the male breast by ablative surgery (orchiectomy, adrenalec tomy, and hypophysectomy) and hormone therapy (estrogens and corticosteroids); an analysis of 42 patients.


Nucleic acid metabolism in regenerating rat liver. VI. Soluble enzymes which convert thymidine to thymidine phosphates and DNA.


Cardiac surgery.

Cardiac surgery.


Poliomyelitis: Southern Rhodesia 1958.

Poliomyelitis: Southern Rhodesia 1958.


The effect of multivitamin tablets and powdered milk on convalescent patients who had recovered from pulmonary tuberculosis.


Halothane, a new anaesthetic agent. II. Its use in the semi-closed circuit.


African onchocerciasis.

African onchocerciasis.


A survey of otosclerosis and its surgical treatment.


The use and abuse of hormone therapy in gynaecological disorders.


Intrapleural irrigation for reducing postresectional fever and pleural reaction.


Surgical treatment of carcinoma of the esophagus and cardia of the stomach: analysis of 240 cases with 72 resections.


Clinical manifestations of subacute bacterial endocarditis.


Treatment and prognosis of subacute bacterial endocarditis.


Acute subendocardial myocardial necrosis: report of 11 cases.


Treatment of infantile diarrhea with neomycin.


Congenital absence of the spleen; report of a case.


STUDIES on schistosomiasis japonica in new China.


A clinical study of 1,000 consecutive cases of mitral stenosis two to nine years after mitral valvuloplasty.


Role of connective tissue ground substance in degenerative disease.


Mitral incompetence caused by disease of the mural cusp.


Evaluation of operability in patients with pulmonary hypertension by catheterization and occlusion of patent ductus arteriosus.


Relationship between diuretic and antihypertensive effects of chlorothiazide and mercurial diuretics.


Dietary fat, serum cholesterol levels and incidence of atherosclerosis in Delhi.


Differential lung function in atrial septal defect.


Influence of some vasoactive drugs on fibrinolytic activity.


Changes in proteins and lipoproteins in diabetes and their relationship to vascular degeneration.


Left ventricular activation time in normal men.


Left ventricular activation time in left ventricular hypertrophy and in left bundle-branch block.


Design of a clinical ultra-low frequency ballistocardiograph.


Extrapulmonic stenosis of the pulmonary veins.


Studies of fat lipolysis by post-heparin human plasma lipoprotein lipase and by human pancreatic lipase.


An evaluation of the nitrous oxide method for the quantification of left-to-right shunts; an experimental comparison of the gasometric technic with directly metered blood flows.


Right atrial myxoma.

Right atrial myxoma.


Use of a calcium chelating agent (NaEDTA) in cardiac arrhythmias.


A large whale heart.

A large whale heart.


Occlusive disease of the carotid arteries.


Clinical evaluation of chlorothiazide.

Clinical evaluation of chlorothiazide.


Iproniazid and angina pectoris.

Iproniazid and angina pectoris.


Familial patterns in hypertension and coronary heart disease.


Demonstration of muscle sphincters as a capillary component in the human heart.


Iproniazid in angina pectoris; a double-blind study.


Pitfalls in the electrocardiographic diagnosis of left ventricular hypertrophy; a correlative study of 200 autopsied patients.


Effects of intravenous administration of fibrinolysin (plasmin) in man.


Effect of anticoagulants on experimental cerebral infarction; clinical implications.


Effect of oxygen on pulmonary vascular resistance in patients with pulmonary hypertension associated with atrial septal defect.


Studies made by simulating systole at necropsy. XII. Estimation of the initial cardiac forces from the ballistocardiogram.


Arachnodactyly heart.

Arachnodactyly heart.


Staphylococcal infections of the heart.

Staphylococcal infections of the heart.


Rupture of the ventricular myocardium and perforation of the interventricular septum complicating acute myocardial infarction.


Fats, cholesterol, and coronary heart disease; a review of recent progress.


Cardiac response to exercise.

Cardiac response to exercise.


The adrenal gland and the cardiovascular changes in acute anoxic anoxia in dogs.


Coronary dilatation and constriction visualized by selective arteriography.


Effect of histamine and of the anaphylactic reaction on isolated guinea pig atria.


Unipolar potential measurements in the electric field produced by an arbitrary dipole in a circular homogeneous lamina.


Blood flow in the aortic wall.

Blood flow in the aortic wall.


Distribution of myocardial blood flow in the rat.


Activation of the ischemic ventricle and acute peri-infarction block in experimental coronary occlusion.


Changes in heart rate during levarterenol infusion; an index of arterial elasticity.


Influence of emotional and physical stimuli on pressure in the isolated vein segment.


Effect of bilateral internal mammary artery ligation on coronary circulation in dogs.


Effect of alcohol ingestion on experimental chicken atherosclerosis.


Responses of dog's pad vessels to epinephrine following sympathectomy or denervation.


Mechanisms of cardiac control in exercise.


Estimation of cardiac output from precordial dilution curves in patients with cardiopulmonary disease.


Some determinants of coronary collateral blood flow in the open-chest dog.


Effect of increased renal venous pressure on circulatory autoregulation of isolated dog kidneys.


Effect of elevated left atrial pressure and decreased plasma protein concentration on the development of pulmonary edema.


Effect of anticoagulants on recanalisation.


A continuous cardiac output recorder employing the Fick principle.


Cardiac effects of isoproterenol, norepinephrine and epinephrine in complete A-V heart block during experimental acidosis and hyperkalemia.


[Comment on the article Dieresis of the senile femur neck].


[Note on the article Various aspects of cancer of the bladder].


An improved technique of agar-gel electrophoresis on microscope slides.


The interaction between dyes and serum proteins in paper electrophoresis; some quantitative problems.


The colorimetric estimation of serum fatty esters.


A rapid micromethod for determining serum calcium.


The antiplasmin effect of plasma fractions.


Studies on fast-moving albumins in human serum.


Serial electrophoretic studies of the serum glycoproteins and proteins in patients with pulmonary tuberculosis.


Spectrophotometric determination of chromium in human plasma and red cells.


A simple colorimetric method for estimating serum pseudocholinesterase.


The effect of factors contained in the membranes of red blood cells on the shape of the dissociation curve of hemoglobin.


Arteriovenous difference of calcium and citric acid in hyperparathyroidism.


An improved glucose-oxidase method for determining blood, C.S.F. and urine glucose levels.


The determination in urine of some metabolites of tryptophankynurenine, anthranilic acid and 3-hydroxyanthranilic acid- and reference to the presence of o-aminophenol in urine.


Physico-chemical studies on four macroglobulins.


Investigations on the influence of tolbutamide on carbohydrate metabolism. III.


The effect of self- and external radiations on 131I-labelled L-thyroxine and 3,5,3'-triiodo-L-thyronine in solution.


Effect of DPN on the inhibition of rat liver 3-hydroxyanthranilic acid oxidase by 2-acetylaminofluorene and N-2-fluorenyldiacetamide.


The assay of arylsulphatases A and B in human urine.


Fluorimetric method for differential estimation of the 3-O-methylated derivatives of adrenaline and noradrenaline (metanephrine and normetanephrine.


Ethylene and propylene glycol in the pre-staining of lipoproteins for electrophoresis.


Disorders of amino acid metabolism in protein deficiencies and their correction.


Studies on the serum proteins. IV. The dye-binding of purified serum proteins separated by continuous-flow electrophoresis.


Studies on the photometric determination of phenylpyruvic acid in urine.


Current views on the process of urea formation in animals.


The determination of catechol amines in blood.


PANEL discussion: the pediatrician's role in early child development.


Untoward reactions following the use of prochlorperazine (compazine): a report of two cases.


Case conference: fulminating viral hepatitis.


Enuresis: a psychiatrist's view.

Enuresis: a psychiatrist's view.


Enuresis: literature review.

Enuresis: literature review.


Enuresis: a pediatrician's view.

Enuresis: a pediatrician's view.


The recognition of coagulation defects and blood dyscrasias prior to operation.


Disorders of the shoulder.

Disorders of the shoulder.


[Electrocortical dual response to luminous stimulation in the newborn kitten].


[Effect of thyroid insufficiency on urinary, water, sodium & potassium elimination in rat].


Contributions to a pathography of the musicians: 1. Robert Schumann.


Psychotherapy and human values.

Psychotherapy and human values.


The role of the private physician in the detection of cancer of the lung.


The role of the private physician in the detection of cancer of the breast.


Vaginal hysterectomy.

Vaginal hysterectomy.


Congenital aortic and subaortic stenosis.


Plumbism following the use of a blow-torch on paint.


The Yale-New Haven Medical Center.

The Yale-New Haven Medical Center.


Robert Lee Rowley; 1879-1959.

Robert Lee Rowley; 1879-1959.


Carbohydrate metabolism in the rumen.

Carbohydrate metabolism in the rumen.


Observations on levels of vitamin A and other factors in shipped feeder calves.


Ultrafiltrable serum calcium levels in normal Holstein-Friesian cattle and in parturient paresis.


A study of Leptospira pomona bacterin in cattle.


The isolation of Leptospira hyos from a new host, Peromyscus maniculatus.


Attempts to demonstrate the transmissible agent of scrapie in experimentally infected goats by means of fluorescent antibody.


Microelectrophoresis of bovine spermatozoa.


Epileptogenic effects of an auditory cortex meningioma in a cat.


Religion and the rise of veterinary medicine.


A new surgical approach to inguinal hernias in the dog.


Somatically oriented obsessive behavior in the monkey.


The evaluation of brucellosis vaccination at 4 and 8 months of age.


The effect of certain mild stresses to the bovine teat canal on infection with Streptococcus agalactiae.


Comparative studies of a Canadian strain with New York strains of infectious pustular vulvovaginitis virus and with infectious bovine rhinotracheitis virus.


A note on exsheathing mechanisms of third-stage larvae of Haemonchus contortus.


Comparative suicide statistics. I. International comparisons.


Pancreatitis.

Pancreatitis.


Comparative suicide statistics. II. Death rates from suicide in Denmark since 1921, and seasonal variations since 1835.


The peripheral blood leukocytes in chronic renal insufficiency.


The peripheral blood leukocytes in acute anuria.


Uropepsin excretion and vitamin B12 absorption in pernicious anaemia and gastric achlorhydria.


Diphtheria vaccination. The Danish National Morbidity survey of 1950. Communication No. 22.


Salmonellosis.

Salmonellosis.


Man and his food intake.

Man and his food intake.


Practical aspects of blood grouping in paternity suits.


Our muscles.

Our muscles.


Northern European medicine and insurance.


Massive extramedullary myelomatosis of the liver: a case report with review of pathological findings.


Cushing's syndrome secondary to focal adrenal cortical hyperplasia; case report of successful surgical treatment by bilateral total adrenalectomy.


Acute myocardial infarction masked by both left bundle branch block and delirium tremens.


Congenital abnormality of the gallbladder; a case report.


Staphylococcal septicemia; a review of 30 cases.


Pulmonary problems: a panel discussion. I. The management of pulmonary malignancies. II. Pulmonary function studies in diagnosis and prognosis. III. Sensitivity tests to antibiotics in clinical practice.


[Effects of surgery of aortic isthmic stenosis on the arterial pulse].


[Trial of a new corticosteroid].

[Trial of a new corticosteroid].


Clinic experience with a urine PAS test.


The incidence of pulmonary tumors in mice exposed to aerosols of therapeutic agents; an evaluation of the possible carcinogenic properties of penicillin, pyribenzamine, adrenalin, cortisone, trypsin and desoxyribonuclease.


The tuberculin test: a tool in case finding.


The place of excisional surgery in the treatment of pulmonary mycotic infections.


The effect of drugs upon the infectiousness of postthoracotomy pleural air spaces and tuberculous empyemas.


Treatment of clotted hemothorax with fibrinolysin.


Diabetic neuropathy; review of literature and a case report with post-mortem findings.


Biochemical changes in skeletal muscle in patients with uncontrolled diabetes mellitus.


Structure and function in diabetic nephropathy; the importance of diffuse glomerulosclerosis.


Comparative study of concentrations in the blood of para-aminosalicylic acid in tuberculous patients.


Diabetes mellitus at ages one to five; findings at onset.


Postinflammatory tumor (xanthoma) of lung.


Metabolic and endocrine studies with phenethyldiguanide (DBI).


Some thoughts on results following intermittent streptomycin in pulmonary tuberculosis.


Nonatheromatous peripheral vascular disease of the lower extremity in diabetes mellitus.


The significance of the action of insulin upon muscle membrane potential.


Lung abscess in the mentally ill as a complication of electric shock treatment.


Artificial coughing, a new apparatus for paralyzed patients.


Effect of prolonged administration of glucagon in guinea pigs.


The individual man and medicine.

The individual man and medicine.


Effect of prolonged administration of tolbutamide in depancreatized dogs.


A secure and adjustable support for thoracentesis.


The effect of exercise on left to right shunt of blood through a ventricular septal defect.


The importance of the myocardial factor in the surgical treatment of rheumatic aortic stenosis.


Myocardial infarction, its diagnosis and treatment; literature review.


Degenerative lesions in dogs with experimental diabetes.


Metabolism of insulin-I 131; studies in isolated, perfused rat liver and hindlimb preparations.


Diagnosis and treatment of acute coronary heart disease without objective findings.


Electrocardiogram of the month; vagal hyperirritability.


Effects of insulin with and without tolbutamide in a depancreatized woman.


X-ray film of the month.

X-ray film of the month.


Obstructive segmental emphysema after chest trauma.


Aneurysm of the pulmonary artery; report of a case diagnosed by angiocardiography and explored surgically.


Long-term results of chemotherapy in tuberculosis.


One-stage abdominoperineal operation for cancer of the rectum.


Surgical treatment of ulcerative colitis: early results after colectomy and low ileorectal anastomosis.


Dimensional aspects of preventive psychiatry (personality dimensions and the prediction of response to treatment.


The contribution of social psychiatry to preventive psychiatry.


Management of imperforate anus.

Management of imperforate anus.


Material aspects of mental disease.

Material aspects of mental disease.


Application of the conditional reflex method to preventive psychiatry.


Pseudomembranous enterocolitis.

Pseudomembranous enterocolitis.


Convergence of psychodynamic and physiodynamic approaches in psychiatric research.


Theory on the cause of psychoneurotic symptoms based on observations of their treatment with an energizer.


Clarification of the action of successful treatment in the depressions.


Neurogenic tumor of the rectum.

Neurogenic tumor of the rectum.


The cerebral hemispheres, the unadapted state and schizophrenia.


Malignant melanoma of the anorectum.

Malignant melanoma of the anorectum.


A comparative study of adolescents with a new drawing test of projective technique.


An attachment for teaching sigmoidoscopic diagnosis and treatment.


Graphic illustration in medical writing.


Pilonidal disease: a new concept of pathogenesis.


Management of adenomas of the colon and rectum showing malignant changes: report of 44 cases treated by local removal.


The psychiatric armamentarium: available forms of psychiatric treatment and their indications.


Villous tumor of rectum and a portion of the sigmoid flexure causing severe electrolyte imbalance.


Relaxation of the internal anal sphincter in anorectal surgery.


Effectiveness of various electro-stimulative technics.


Problems of indications as viewed by a psychoanalyst.


The present status of insulin shock treatment at Brooklyn State Hospital.


Appraisal of milieu therapy.

Appraisal of milieu therapy.


Appraisal of drug therapy.

Appraisal of drug therapy.


CO2 therapy in broad spectrum psychiatric treatment.


Care and treatment of the senile and arteriosclerotic mental patient.


Gonadal immaturity as an etiological factor in some forms of mental deficiency, and its therapy.


The aging process; physiologic and pathologic.


Unidirectional current, modified by succinylcholine in electroconvulsive treatment of the aged.


Methohexital anesthesia in electrocerebral therapy.


Succinylcholine modified EST.

Succinylcholine modified EST.


New aid to neurology: measurements with calibrated sedac.


High frequency electric currents (Sedac) for brain measurements, diagnosis, therapy.


Unidirectional regressional modified ECT vs. tranquilizers in chronic schizophrenics.


On mental depressions.

On mental depressions.


Psychodynamic alterations concomitant with intensive meprobamate administration.


Effect of phenothiazine derivatives on liver function.


Histopathologic findings in the liver and C.N.S. following administration of tranquilizing drugs.


Prognostic application of psychological techniques in convulsive therapy.


Differential narco-stimulation.

Differential narco-stimulation.


Establishment of menstruation in the mentally defective.


An analysis of 133 homosexuals seen at a university student health service.


On the epinephrine; mecholyl test.

On the epinephrine; mecholyl test.


Stiff-man syndrome; analysis and case report with spinal cord autopsy.


Dynamics of group psychotherapy.

Dynamics of group psychotherapy.


Deanol: a clinical trial.

Deanol: a clinical trial.


Treatment of depressive states in office practice.


Preliminary study of isocarboxazid, an iproniazid analog.


Aging within hallucinations.

Aging within hallucinations.


Specificity of the hypocholesterolemic activity of nicotinic acid.


Clinical and EEG observations in patients with progressive muscular dystrophy.


Spectrophotometric studies on urinary constituents of schizophrenic subjects.


Acute brain syndrome; clinical study of 122 patients.


Trifluoperazine in anxiety and tension states.


Dartal in treatment of hospitalized schizophrenic patients.


Convulsive therapy without curarization in severe somatic complications.


Intravenous use of tripelennamine hydrochloride as a narcotic-like substitute.


Notes on some ixodid ticks in the Nairobi area.


The radiological diagnosis of the acute pneumonia in children; a preliminary report.


Human cryptococcosis in Kenya.

Human cryptococcosis in Kenya.


A case of cryptococcosis with choroidal torulomata.


Adenolymphocoele and elephantiasis in onchocerciasis.


Primary carcinoma of the fallopian tube.


A case of pulseless disease of Takayashi's disease.


A case of periarteritis nodosa.

A case of periarteritis nodosa.


A metastasis of renal carcinoma masquerading as a femoral aneurysm.


Sustained release in pelleted preparations as judged by urinary excretion and in vitro methods.


A collaborative study on the detection of particles in ampuled solutions.


Stability data requirements under the new drug regulations.


Nonaqueous titration of some 9-aminoacridine derivatives.


Rat blood pressure test for pressor substances and biological assay of epinephrine.


Hippocampal electrical activity during the development of conditioned reflexes.


Cerebello-hippocampal influences on the electroencephalogram.


Hippocampal and neocortical activity in different experimental conditions.


Studies on the supracallosal mesial cortex of unanesthetized, conscious mammals. I. Cat. A. Movements elicited by electrical stimulation.


Studies on the supracallosal mesial cortex of unanesthetized, conscious mammals. I. Cat. B. Electrical activity.


Conditioning of reticular formation stimulation effects.


Provocation of electroencephalographic changes in the temporal region by intermittent acoustic stimuli.


The blocking of the rolandic wicket rhythm and some central changes related to movement.


Defensive conditioning of electrographic arousal with delayed and differentiated auditory stimuli.


Electrocorticographic changes in temporal lobe epilepsy at rest and during induced sleep.


Analysis of cerebral responses to flicker in patients complaining of episodic headache.


Evidence for the existence of an electroencephalographic synchronization mechanism originating in the lower brain stem.


Epilepsy in conjoined Siamese twins.

Epilepsy in conjoined Siamese twins.


Transient electroencephalographic pattern characteristic of subacute leuco-encephalitis in a case of acute head injury.


The prevention of the transmission of viral hepatitis by needle electrodes.


The EEG in necrotizing encephalitis.

The EEG in necrotizing encephalitis.


A simple device for minimising the effects of blocking in resistance-capacity coupled amplifiers.


A method for recording and reproducing programmed stimuli: a basis for accurately evaluating the cerebral electrical response to sensory stimulation.


A transistor timed stimulator.

A transistor timed stimulator.


Simultaneous two channel frequency analyzer with non-electronic (passive) filters.


Aldosterone secretion in dogs with hypothalamic lesions.


Relationship of the parathyroids to bone phosphorus.


Extraction of thyrotrophin from pituitary glands, mouse pituitary tumors, and blood plasma by percolation.


Steroidogenic properties of extracts of beef diencephalon.


A radiomimetic effect of triethylenemelamine on reproduction in the male rat.


The resistance of thyrotrophic and adrenocorticotrophic hormones towards purified thyroid and adrenal proteinases.


Action of estrogen and progesterone on mammary nucleic acids and enzymes in rats.


Effect of di-ethyl ether anesthesia on thyroid function of rats.


Hormonal influences on the carbonic anhydrase concentration in the accessory reproductive tracts of the rat.


Effect of bovine pituitary growth hormone on hepatic cholesterogenesis of hypophysectomized rats.


Effects of o,p' DDD on histology and 17-hydroxycorticosteroid output of the dog adrenal cortex.


Effect of cortisone, 9-alpha fluorocortisol, and growth hormone on the action of tolbutamide.


Deiodination of thyroxine by heat-killed rat kidney cortex.


Inhibition of thyroidal iodide concentrating by triiodothyronine: evidence for an effect not due to depression of thyrotrophin but dependent on the pituitary.


The inhibition of the metabolism of thiocyanate in the thyroid of the rat.


The nature of the sexual dimorphism of the submandibular gland of the mouse.


Intestinal absorption of insulin in the rat.


The response of ovarian explants from post-natal mice to gonadotropins.


Effects of hypophysectomy on some functional aspects of the adrenal gland of the chicken.


Adrenaline concentration in the rat uterus after adrenaline administration by different routes.


Enzyme pacemakers. IV. Conversion of proribonuclease to ribonuclease.


Enzyme pacemakers. V. Conversion of prodeoxyribonuclease to deoxyribonuclease.


Intracellular behaviour of the nitrate reductase of animal tissues.


Applications of catalase.

Applications of catalase.


Results of examination of lung function in tuberculosis.


The structure of collagen in the light of various physical, chemical and biological investigations.


An experimental study of flare in a new micro-spectrophotometer.


Characteristics and significance of the elementary hematopoietic function as revealed in spleen tissue of lethally-irradiated frogs.


Synthesis of ribonucleic acid in plants. I. Distribution of ribonucleic acid and of protein among subcellular components of pea epicotyls.


The response of glycolytic and non-glycolytic mammalian cells to the inhibitory action of fluoro-pyruvate.