Synthesis of ribonucleic acid in plants. II. Phosphate-32P incorporation into the ribonucleic acid of the pea epicotyls.


Further experiments on jelly-free sea urchin eggs.


A paradoxical effect of aeration on the accumulation of root-tip metaphase cells by spindle inhibitors.


The action of thyroxine and triiodothyronine on human cells growing in tissue culture.


Proportionality between nuclear DNA-content and Feulgen dye-content.


A difference in nucleic acid preparations from Ehrlich ascites nuclei and calf thymus nuclei.


An electron microscopic study of Entamoeba invadens Rodhain 1934.


Synchronized budding of yeast cells following x-irradiation.


Dynamic aspects of a method in tracer kinetics.


Studies on reticulocyte division.

Studies on reticulocyte division.


The characteristics of a cell line derived from white matter of Macacus rhesus.


A note on omega-bromoallyl glycine-induced pycnosis in explanted chick embryos.


The effect of ribonuclease on Hartmanella astronyxis.


Restoration of diaphragmatic function following vagophrenic anastomosis in the rat.


Course of fibers of brachium conjunctivum revealed by evoked potential method.


Direct contralateral inhibition in the lower sacral spinal cord.


The innervation of the urethra of the female cat.


Growth of nerve fibers into skin and muscle grafts in rat brains.


Neuronal reaction to injury during development: severance of the facial nerve in utero.


Early effects of intensive x-ray irradiation of the diencephalon in the rat.


Substrate utilization by rat sciatic nerve.


Oxidative metabolism of sciatic nerves of hens following insecticide poisoning.


Brain damage in the monkey, macaca mulatta, by asphyxia neonatorum.


Dehydropeptidase I activities in human intracranial neoplasms.


Role of the sympathetic nervous system in the pupillary response to darkness.


The effects of brain-stem stimulation on hind-leg movements in the hooded rat.


Isolation and characterization of deposits of secretion from the acetabular gland complex of cercariae of Schistosoma mansoni.


Recovery of Schistosoma mansoni from hormonally imbalanced hosts.


Experimental studies on morphological variation in the cestode genus Hymenolepis. II. Growth, development and reproduction of the strobilate phase of H. nana in different mammalian host species.


Chemical inhibition of sporulation of Eimeria bovis oocysts.


Chromosomes in parthenogenetic miracidia and embryonic cercariae of Schistosomatium douthitti.


The enhanced folic and folinic acid contents of erythrocytes infected with malaria parasites.


Studies in helminth enzymology. II. Properties of an inorganic pyrophosphatase from Ascaridia galli, a nematode parasite of chickens.


Egg-shell formation in trematodes and cestodes.


Electronic pupillography. Why, how and when.


Treatment of diffuse external otitis; further observations.


Cerebrovascular disease from the point of view of the otolaryngologist.


Use of contact lenses by a three year old partial albinotic with high myopia; case report.


Major changes in medical education during the past fifty years.


[Principal physiological problems according to decisions of the 21st Congress of the Communist Party of the USSR].


Defects of articulation.

Defects of articulation.


Major issues of aging.

Major issues of aging.


Early probing for congenital dacryostenosis.


Chlorothiazide in the treatment of arterial hypertension.


The treatment of common skin diseases.

The treatment of common skin diseases.


Pulmonary arteriovenous aneurysm.

Pulmonary arteriovenous aneurysm.


The Staphylococcus problem and antistaphylococcal antibiotics.


The basis for the choice and use of new drugs.


A multipurpose instrument for suction biopsy of the esophagus, stomach, small bowel, and colon.


An esophagogastroscope for visualization of blind areas.


Lesions in upper portion of the gastrointestinal tract associated with intracranial neoplasms.


Intracranial infections causing esophagomalacia and gastromalacia: a postmortem study of eleven cases. V. Ulcer and brain.


I 131-labeled protein and fat meals in patients with chronic pancreatitis.


The association of peptic ulcer with hereditary hyperparathyroidism.


Diarrhea caused by Escherichia coli serotype O127: B8; microbiologic and clinical aspects.


Roentgen diagnosability of gastric ulcer: a review of 100 proved cases of carcinoma of the stomach.


pH in situ of esophageal and gastric contents, with particular reference to hiatal hernia.


The association of nonspecific jejunitis and granulomatous phlebitis in the legs.


Changes in the icteric index of the duodenal aspirate after the injection of secretin and pancreozymin.


The mechanism of inhibition of gastric acid secretion by the duodenum.


The changes produced by phenylbutazone in the gastric secretion of the guinea pig.


Phenylbutazone and gastric ulceration in the guinea pig.


Giant air cyst of the abdomen; an unusual manifestation of diverticulitis of the sigmoid: report of a case.


The gastric ulcer; benign or malignant.

The gastric ulcer; benign or malignant.


Chevalier Jackson: 1865-1958.

Chevalier Jackson: 1865-1958.


[Value of cycloserine treatment of pulmonary tuberculosis under radiological control].


[Bronchi in aged].

[Bronchi in aged].


[Contribution to the knowledge of the behavior of C-reactive protein in pleuro-pulmonary tuberculosis].


Diabetes in Hawaii. I. Prevalence.

Diabetes in Hawaii. I. Prevalence.


Sarcoidosis in Hawaii; case report and discussion.


Oxytocics in the induction of labor; dangers, uses, and precautions.


Research with feebleminded.

Research with feebleminded.


Work of Tissue Culture Laboratory in Hawaii.


A symposium: the two-step exercise test.


Value of the postexercise electrocardiographic test.


Reversible gluco-amino-phosphaturia in a child with lipoid nephrosis.


[Changes in aminoaciduria observed in cases of kwashiorkor; study by chromatography on ion-exchange column].


The Master test in patients with coronary heart disease and in normal subjects.


Paper chromatography for amino-acids in thirst fever.


Transposition of the great vessels.

Transposition of the great vessels.


Stress and the heart.

Stress and the heart.


Pheochromocytoma; evaluation of pharmacologic and chemical tests as an aid to diagnosis.


After office hours; a visit with Dr. Jean Paul Pratt.


Present status of optical corneal grafts.


Interrelationship between brain damaging processes and peptic ulceration, perforation and hemorrhage.


The staphylococci.

The staphylococci.


Electron microscopy of the free border of the human intestinal epithelial cell.


Clinical evaluation of renal tubular phosphorus reabsorption test.


The effect of maternal hypoxia upon fetal dental enamel.


Hypothalamic control of the adenohypophysis.


Cervical incompetence.

Cervical incompetence.


Chronic occlusive diseases of the peripheral arteries.


[Investigations on the biosynthesis of proteins. I. Synthesis of radiocarbon labeled amino acids in proteins of cell free nucleoprotein-enzyme-system of Escherichia coli].


Physiotherapists and the law in Great Britain.


Chain of command.

Chain of command.


The role of the civilian hospital in the Medicare program.


Hospital pharmacy of the future.

Hospital pharmacy of the future.


Pharmaceutical detailman; liability or asset.


An infection committee that works.

An infection committee that works.


Hospital sanitation. I.

Hospital sanitation. I.


The pharmacist's increased responsibilities for purchasing under the formulary system.


The training of hospital administrators in Great Britain.


Revised hospital medical injection costs study (1958).


How to cut cost of printed forms.

How to cut cost of printed forms.


It can be done successfully.

It can be done successfully.


Staphylococcal infections in infants and mothers. I.


Emergency evacuation of chronically ill patients.


Job study and specifications for a good purchasing agent.


Accident survey helps eliminate causes.

Accident survey helps eliminate causes.


The significance of hospital accreditation to health insurance.


The hospitals of Rome in the 1830's.

The hospitals of Rome in the 1830's.


A pause to applaud a P. R. parade.

A pause to applaud a P. R. parade.


The public role of the hospital sister.

The public role of the hospital sister.


A legal look at progressive patient care. II.


Six requisites for communication.

Six requisites for communication.


Some factors in translating hours of clinical practice.


Plan your inservice training.

Plan your inservice training.


Food service managers can help solve dietary problems.


Mother of universal charity.

Mother of universal charity.


Centralized personnel: here's how.

Centralized personnel: here's how.


Hospital pharmacy as viewed by nursing service.


FIRST-CLASS mail; privileges and limitations.


Dispensary progress.

Dispensary progress.


Housekeeping: as a fiscal service.

Housekeeping: as a fiscal service.


The inside story of a workshop.

The inside story of a workshop.


Libraries, scholarship and the student in nursing.


The medical record technician: who is she? What can she do.


From an integrated approach to design: a 'hospital for life'.


Of beds and inpatients.

Of beds and inpatients.


It's in the cards; integrated accounting for small hospitals.


Judging a volunteer program means judging its director.


Nurses shaped this volunteer program.

Nurses shaped this volunteer program.


Electronic monitor speeds maintenance service.


A simplified stock ordering system.

A simplified stock ordering system.


A scientific method for medical auditing. I.


How Michigan hospital saved $73,000 in labor costs.


How linen handling methods affect cross-infection rate.


Good community relations; attitudes outweigh techniques.


A hospital's people are its richest resource.


Weekly meetings thrash problems, build loyalty.


Diverse talents multiply board's opportunities.


Hard-working ambassadors merge hospital-community aims.


Physician-publicists lead vigorous immunization drive.


Community help is there for the asking.

Community help is there for the asking.


Town tunes in on its hospital's drama.

Town tunes in on its hospital's drama.


A scientific method for medical auditing.


Fair exhibits and printed materials reach wide audiences.


Workbook charts relationships with five hospital publics.


Pharmacy procedure manual: policy guide and evaluation tool.


It's the people who make most of the noise.


Food service problems and their solutions.


Hospital-physician liability: a growing problem.


How state medicolegal committees can make patient care better and safer.


Hospital-physician liability: inhospital medicolegal education committees can pinpoint problem areas.


A PICTURE tour of AHA headquarters.

A PICTURE tour of AHA headquarters.


Forces that may bring compulsory health insurance.


Are we overestimating nursing needs.

Are we overestimating nursing needs.


The four musts for sharing supervision.

The four musts for sharing supervision.


Differential fertility in relation to body dimensions.


Oral tablets help control ward odors; study shows.


A hospital program for training executive housekeepers.


Studies on the occipital bone in Africa. IV. Components and correlations of occipital curvature in relation to cranial growth.


Social distance in epidemiology; age of susceptible siblings as the determining factor in household infectivity of measles.


The dependence of permanent tooth loss upon tooth morbidity.


Thickening of the subcutaneous tissues in paralyzed limbs in chronic hemiplegia.


The senior citizen: solution a local problem.


The present status of dermatologic x-ray therapy.


Agglutination tests in patients and families with rheumatoid arthritis.


Toxic effects of drugs used in the treatment of cardiovascular disease.


THE MULTIPLE injury patient.

THE MULTIPLE injury patient.


A generalist views public health.

A generalist views public health.


The low salt syndrome in congestive heart failure: the importance of dietary sodium restriction.


Serum glutamic oxalacetic transaminase activity in various diseases.


Chlorpromazine; four years later.

Chlorpromazine; four years later.


Contact lenses.

Contact lenses.


IRON ENZYMES in iron deficiency states.

IRON ENZYMES in iron deficiency states.


Diet, exercise, and coronary disease.

Diet, exercise, and coronary disease.


The treatment of Meniere's disease with ultrasonic waves.


Non-peregrinating hysteria of Munchausen.


OBITUARY notice: Major-General Sir John Taylor.


Observations of the nature of genetic recombination in Vibrio cholerae.


Proventricular teeth in some rat fleas.

Proventricular teeth in some rat fleas.


Studies in anaemia of infection. III. Mechanism of hypoferraemia; influence of body temperature on plasma iron.


Studies in anaemia of infection. IV. Mechanism of hypoferraemia: effect of infection on the absorption, excretion, and tissue distribution of iron.


Experimental peptic ulceration. V. Adrenal function in histamine induced ulceration.


Effect of gonadectomy on experimental peptic ulceration.


Pharmacological studies of Herpestis monniera, Linn., (Brahmi).


Problem of standardization of liver preparation. III. Studies on optical absorption and N/P ratios of various liver extracts for parenteral use.


Toxicity limit of argimone oil.

Toxicity limit of argimone oil.


Vesico-renal reflex.

Vesico-renal reflex.


Some effects of introducing HCI into human stomach.


Spermicidal action of sodium nimbinate.

Spermicidal action of sodium nimbinate.


Studies on the breeding and maintenance of a colony of albino rats; growth and breeding performance of albino rats.


Studies on pyridine nucleotide metabolism. III. Effect of protein deficiency on the synthesis of ribose phosphate from glucose-6-phosphate in rat liver and blood.


The effective use of human resources.

The effective use of human resources.


Studies on human lactation. I. Diet survey of lactating women in different socio-economic groups and the effects of socio-economic status and stage of lactation on the proximate principles and essential aminoacids of human milk.


Studies on human lactation. II. Effect of socio-economic status on the vitamin content of human milk.


The Tenth All-India Pediatric Conference, Nagpur, 1959; presidential address.


The challenge of occupational health.

The challenge of occupational health.


The challenge of the small plant.

The challenge of the small plant.


The role of the professional society in industrial hygiene.


Role of the medical society in occupational health.


The role of the dental society in occupational health.


Occupational health programs for agricultural and other nonplant workers.


The role of the official agency in occupational health.


The role of organized labor in occupational health.


The role of the nursing organization in occupational health.


The Birmingham Industrial Council; its role in the health program of small plants.


Industrial health clinics.

Industrial health clinics.


What have voluntary health agencies to offer.


Expectations of management regarding occupational health.


Tracing of water flow by means of radioactive isotopes and scintillation counters.


Localization of intracardiac shunts using instantaneous injection of RIHSA with two-site sampling.


The determination of gallium and molybdenum in biological material by activation analysis.


Isotopic analysis of oxygen in inorganic compounds.


The use of triacetin (fungacetin) in the treatment of superficial dermatomycoses.


Reevaluation of the usefulness of theobromine calcium gluconate for the management of congestive heart failure and anginal syndrome.


Pulmonary fat embolism: case report; fatty liver.


Leonardo da Vinci.

Leonardo da Vinci.


A practical mobilization physical medicine program for control of the industrial backache.


On the biological significance of serotonin.


Dermatological studies of a new antibacterial cutaneous cleansing agent.


Shock, catalepsy, and psychogenic death; the relationship between panic and primary, secondary, and tertiary shock.


Studies in neurological structure. I. Aromatic and aliphatic systems.


Vasospasm and cold.

Vasospasm and cold.


Cardiovascular effects of salicylate overdosage.


Hypothermic myxoedema coma.

Hypothermic myxoedema coma.


The control of potassium intoxication.

The control of potassium intoxication.


Diverticulum of the female urethra.

Diverticulum of the female urethra.


Craniosynostosis.

Craniosynostosis.


David Rittenhouse and the illusion of reversible relief.


Tuberculin testing, chemoprophylaxis, and BCG vaccination.


A hearing survey in the public schools of Jerusalem.


Studies on the experimental typhoid. III. Histopathological study of the mice liver infected with virulent or attenuated S. enteritidis strain.


A rapid in vitro screening test for antitumor substance on the filter paper.


Differential staining method for dead and live tumor cells.


Studies on the mechanism of ossification in tissue culture. II. Effects of adenosinetriphosphate and phosphocreatine on the growth of chick embryo femur.


Relationships between types of adenovirus indicated by heterologous neutralization.


Taxonomical notes on the female terminalia of some Anopheline mosquitoes of Japan and Formosa (with the key to the species and 13 plates); taxonomical and ecological studies on mosquitoes of Japan. 12.


Miyagawanella: psittacosis-lymphogranuloma group of viruses. 9. Psittacosis of canary-birds in Japan.


Cultivation of Yoshida sarcoma cells in the simplified replicate tissue culture.


The influence of body build and posture on the expiratory reserve volume.


Tetanus treated by prolonged anesthesia; a case report.


The interference theory of forgetting and the amnesic syndrome.


Recency and primacy in persuasion as a function of the timing of speeches and measurements.


Personal motivations and self-conceptions associated with effectiveness and ineffectiveness in emergent groups.


Social isolation vs interaction with adults in relation to aggression in preschool children.


Regional differences in anti-Negro prejudice.


Relationships of measures of anxiety and experimental instructions to word association test performance.


Attribute criteriality and sex-linked conservatism as determinants of psychological similarity.


Patella cubiti.

Patella cubiti.


Relationships between social need strivings and the development of heterosexual affiliations.


Motivation and language behavior: a content analysis of suicide notes.


Group versus individual problem-solving.


Differences in gradients of stimulus generalization as a function of psychiatric disorder.


Attractiveness of group as function of self-esteem and acceptance by group.


A method for determining types of self-esteem.


Process-reactive schizophrenia and genetic levels of perception.


Suggestibility as dependency behavior.

Suggestibility as dependency behavior.


Conflict and repression during sleep deprivation.


Perceptual preferences as a function of personality variables under normal and stressful conditions.


Phantom experiences in mental defective amputees.


Social perception and the motivational structure of interpersonal relations.


Contradictory results using the mecholyl test to differentiate process and reactive schizophrenia.


The afterimages of hallucinated and imagined colors.


Authoritarianism and reactions to sputniks.


Salience of norms and order of questionnaire items: their effect on responses to the items.


Regression under stress to first learned behavior.


Verbal discrimination of pleasant and unpleasant stimuli prior to specific identification.


Patterns of parenthood as theories of learning.


Human factors applied to study of dentist and patient in dental environment: a static appraisal.


The interrelationship of periodontics and orthodontics.


Concerning the concreteness in schizophrenia.


The chemistry of calcification and its roentgenographic appearance.


The effects of a monetary reward on the acquisition of an imitative response.


Ultrasonic cavity preparation: histopathologic survey of effects on mature and developing dental tissues.


Comparative evaluation of newer devices and technics for the removal of tooth structure: vibration characteristics and patient reaction.


The effects of a ragweed control program on ragweed pollen counts.


Retention of aqueous fluoride by alloxan-diabetic rats.


The effect of heat processing, gamma radiation, and ultraviolet radiation on the anaphylactogenic properties of milk.


Aspirin and placebo in oral surgery.

Aspirin and placebo in oral surgery.


The Mylo-Flex denture.

The Mylo-Flex denture.


On modification of penicillin antigenicity.


Immune sera in the study of food antigens. II. Crustaceans.


A program of dental health education for nurses.


Interest of the state society in financial assistance for dental students.


Development of sensitivity to penicillinase following its use in penicillin reaction.


The mechanism of the Schultz-Dale reaction.


LIST OF certified dental materials revised to May 1, 1959.


Studies on the antigenic relationship of insect extracts by reagin neutralization; evidence for nonspecific inactivation of reagin.


High-efficiency pollen samplers for use in clinical allergy.


SURVEY of the dental laboratory industry. II. Dental laboratory personnel.


COUNCIL announces classification of additional products.


The education and recognition of technical groups associated with medicine.


SURVEY of dentist opinion. I. Introduction.


Opportunities in international nutrition research.


Comparison of dietary survey methods.

Comparison of dietary survey methods.


The interview itself.

The interview itself.


New research in human energy metabolism.


Diets of post-adolescent young women.

Diets of post-adolescent young women.


Use of vegetables in infant feeding through the ages.


The hospital dietitian in a rehabilitation program.


Food attitudes of five- to twelve-year-old children.


Helping handicapped homemakers.

Helping handicapped homemakers.


Programs to fit changing health needs.

Programs to fit changing health needs.


Dietitians and nutritionists in community health programs.


Teaching nutrition; progress and problems.


Are teachers prepared to teach nutrition.


An adventure in nutrition investigation.


Clay- and cornstarch-eating women.

Clay- and cornstarch-eating women.


Foods of the Bible.

Foods of the Bible.


How the chaplain and the dietitian can cooperate.


PANEL discussion on psychotherapeutic measures in the adjustments of our senior citizens.


Gastric remnant interposition in surgery of the esophago-gastric region: preliminary report.


Human problems in geriatrics, with special reference to fecal incontinence.


The unsuccessful aged.

The unsuccessful aged.


Pernicious anemia and aging.

Pernicious anemia and aging.


PANEL discussion on the clinical management of blood dyscrasias in the older age group.


Prognosis after mitral commissurotomy; factors affecting results in ninety-two patients.


Panel discussion on psychiatric emergencies in general practice.


Comparative effectiveness of phenylpropanolamine and dextro amphetamine on weight reduction.


Pyelonephritis; in defense of the urethral catheter.


Innovations in hospital care of newborn infants.


Multiple eczematous sensitivities.

Multiple eczematous sensitivities.


Cerebral manifestation of vitamin B12 deficiency.


Systemic reaction after intravenous fibrinolysin therapy.


Glove powder granuloma in peritoneal cavity.


The management of cardiac arrest.

The management of cardiac arrest.


Clinical use of phenistix reagent strip method of testing urine samples.


Cardiac arrest occurring outside the operating room; demonstration of effectiveness of a trained resuscitation team.


Current status of therapy in rheumatic fever.


Steroid therapy in rheumatoid diseases.

Steroid therapy in rheumatoid diseases.


NEW AND nonofficial drugs: tuberculosis vaccine.


Diet in the management of peptic ulcer.

Diet in the management of peptic ulcer.


CHRONIC Illness Information Center of Cleveland.


This we believe; president's address.

This we believe; president's address.


Is a fluoroscope useful to the general practitioner.


Cold foot; postoperative sign of silent myocardial infarction.


Serotonin metabolism in carcinoid syndrome with metastatic bronchial adenoma.


Appendicitis after appendectomy.

Appendicitis after appendectomy.


The family physician and the adolescent delinquent.


Measurement of free acid in gastric juice by means of indicator paper.


Blood disappearance of radioactive rose bengal; rapid simple test of liver function.


Clinical evaluation of pelvicephalography; review of 1, 200 cases.


Problems in hysterosalpingography.

Problems in hysterosalpingography.


Is isolation of infants with thrush necessary.


Adenocarcinoma; unusually long survival time in case of known tumor recurrence.


New, rapid method of obtaining dry, fixed cytological smears.


Erythema nodosum as a manifestation of histoplasmosis.


Steroid therapy in systemic infections.

Steroid therapy in systemic infections.


From the atom to the patient.

From the atom to the patient.


Methods for the preservation of private medical practice.


Speculation, glamour shares, and sleeper stocks.


Corticosteroid therapy in rheumatoid arthritis; comparative study of effects of prednisone and prednisolone, methylprednisolone, triamcinolone, and dexamethasone.


Circulating lipids in diabetes mellitus.


A new, potent antihypertensive drug: preliminary study of [2-(octahydro-1-azocinyl)-ethyl]-guanidine sulfate (guanethidine).


Clinical studies on hydrochlorothiazide; antihypertensive and metabolic effects.


Staphylococcic wound infections; study of wound infections in several thousand hernia cases.


Newer phenothiazine drugs in treatment of nervous disorders.


Leiomyosarcoma of the uterus with unusual metastases.


Angiocardiographic study of atrial thrombi with surgical-pathological correlation.


Erysipelas in pregnancy; report of a case with fatal outcome.


New anticoagulant for oral use-3-(1'-phenylpropyl)-4 hydroxycoumarin (liquamar); its evaluation for short-term therapy.


Successful treatment by a chest blow of cardiac arrest during myocardial infarction.


Urinary tract allergy.

Urinary tract allergy.


Spontaneous abdominal paracentesis.

Spontaneous abdominal paracentesis.


Steroid therapy in skin disorders.

Steroid therapy in skin disorders.


NEW AND NONOFFICIAL Drugs: valethamate bromide.


NEW AND NONOFFICIAL Drugs: bemegride.

NEW AND NONOFFICIAL Drugs: bemegride.


AUTOPSIES: performance without widow's consent.


Is there a corticosteroid of choice for rheumatoid arthritis.


Reappraisal of surgical treatment of mammary carcinoma.


Preoperative psychiatric consultation.

Preoperative psychiatric consultation.


Cinematography of human retinal vessels: a practical clinical and research technique.


Diagnostic small thoracotomy in idiopathic pleural effusion.


New antibody (anti-RhB) resulting from blood transfusion in an Rh-positive patient.


Syndrome of minimal cerebral damage in infancy.


Fulminating meningococcemia (Waterhouse-Friderichsen syndrome): report of two patients successfully treated with chemotherapy, vasopressors, and adrenal steroids.


Sexual potency in aging males. 1. Frequency of coitus among clinic patients.


Pilonidal sinus carcinoma.

Pilonidal sinus carcinoma.


Follow-up study on a group of older amputee patients.


Observations on ophthalmodynamometry.

Observations on ophthalmodynamometry.


Clinical evaluation of methylphenidate (ritalin) hydrochloride in the newborn infant.


Reactions to orally administered poison ivy extract.


Treatment of acute gout with injection of colchicine.


HEALTH problems in education.

HEALTH problems in education.


Steroid therapy in surgical patients.

Steroid therapy in surgical patients.


Muscle work and body-temperature.

Muscle work and body-temperature.


Practical steps for the family physician in the prevention of emotional disorder.


Results of addition of liothyronine to a weight-reducing regimen.


Modern management of obesity; the social diet.


Scope and interprofessional relations of occupational medicine.


Observations on one hundred cases of cerebral angioma.


Flow sheet for use in obstetric coagulation problems.


Steroid treatment of lye burns of the esophagus.


Simple paper test for determining bacterial sensitivity to antibiotics.


Gas-containing gallstones.

Gas-containing gallstones.


Methylprednisolone (medrol) in the treatment of systemic lupus erythematosus; analysis of results in forty cases.


Urineserum urea nitrogen ratio; simple test of renal function in acute azotemia and oliguria.


Faulty function of table model ethylene oxide sterilizer.


Orthostatic aphasia after cardiac surgery.


Nature of adverse reactions to radiopaque agents; preliminary report.


Steroid therapy in ophthalmic lesions.

Steroid therapy in ophthalmic lesions.


NEW AND nonofficial drugs: azuresin.

NEW AND nonofficial drugs: azuresin.


Is melanoma curable? Long-term survival in consecutive cases of melanoma.


Anita V. Figueredo.

Anita V. Figueredo.


San Diego screening program for cervical cancer.


San Diego Heart Center; pioneer.

San Diego Heart Center; pioneer.


Development of a heart-lung machine.

Development of a heart-lung machine.


Acute hemolytic anemia treated with ACTH.


Thrombosis of the renal artery.

Thrombosis of the renal artery.


Narcotics: a major border problem.

Narcotics: a major border problem.


San Diego medical practice: a historical sketch.


The Navy is my career.

The Navy is my career.


San Diego Polio Plan.

San Diego Polio Plan.


Firsts at the San Diego Zoo hospital.

Firsts at the San Diego Zoo hospital.


Antoinette Le Marquis.

Antoinette Le Marquis.


Physical medicine and rehabilitation; what it encompases.


Role of pediatrician in preventing post-partum depressions.


Liothyronine (L-triiodothyronine) as replacement for thyroid hormone.


Chorioadenoma destruens versus chorioepithelioma.


Service unlimited; AMWA.

Service unlimited; AMWA.


Practical clinical management of fluid and electrolyte deficits in surgical patients.


The cervical mucus arborization test in general practice.


Partial membranous occlusion of the anorectal junction.


A report on 200 cases of mitral commissurotomy.


Staphylococcal pneumonia in infancy.

Staphylococcal pneumonia in infancy.


Anticoagulant therapy in myocardial infarction.


Recurrent anterior dislocation of the shoulder; the Bankart lesion and technic.


Otitis externa.

Otitis externa.


Rapidly progressing ovarian tumor postpartum.


Medical research; unfinished business.

Medical research; unfinished business.


The nutritional aspects of liver disease.


Ilopan and its usage.

Ilopan and its usage.


Review of antibiotic therapy in pediatric infections.


Fractures of the newborn.

Fractures of the newborn.


Urologic considerations for the general surgeon.


A review of some anatomic and physiologic differences as related to anesthesia in the pediatric subject.


A clinical study and evaluation on pangamic acid.


Carcinoma of the cervix during pregnancy.


Case report: long-term management of the Kimmelstiel-Wilson syndrome.


The photo-kinegram in foot therapy.

The photo-kinegram in foot therapy.


Aids for safety shoe problems.

Aids for safety shoe problems.


Dry skin: a further report.

Dry skin: a further report.


Gout and gouty arthritis.

Gout and gouty arthritis.


Vitamin A as an antikeratinic factor.

Vitamin A as an antikeratinic factor.


Vertical integration in livestock production.


Experiences in veterinary aspects of public health in Alaskan Eskimo communities.


Demonstration of the nymph of Linguatula serrata Frolick, 1789 in Sylvilagus floridanus from North Central Oklahoma.


A review of recent findings in infectious diseases of sheep. I. Virus diseases.


Polyarteritis in sheep.

Polyarteritis in sheep.


Vibriosis as a factor in the repoduction of antelope (Antilocapra americana).


An evaluation of piperazine citrate for preventing prenatal infections with the common dog ascarid (Toxocara canis).


Body temperatures of racing greyhounds.

Body temperatures of racing greyhounds.


Veterinary medicine in Hawaii.

Veterinary medicine in Hawaii.


Exotic diseases.

Exotic diseases.


Removal of bone from the esophagus of a pup; a case report.


A review of recent findings in infectious diseases of sheep. II. Bacterial diseases.


Tetanus in the dog; a case report.

Tetanus in the dog; a case report.


Promazine in equine practice.

Promazine in equine practice.


Osteomalacia in horses. I. Nutrition as an etiological factor.


Veterinary medical education and research for today's needs.


Unsatisfactory results with nicotine immobilization of a deer and Brahma crossbread cattle; two case reports.


The standing position for abdominal cryptorchidectomy in the horse.


Isolated pulmonic valvular stenosis in a dog.


The current status of bovine dwarfism.

The current status of bovine dwarfism.


Cerebrospinal fluid pressures of snorter dwarf-carrier and noncarrier cattle.


Angiocardiography for the clinical diagnosis of congenital heart disease in small animals.


Salmonella dublin infection in calves; a preliminary report.


The prevalence of rabies in populations of foxes in the southern states.


Toxicity of Drymaria arenarioides for cattle, sheep, and goats.


An unusual case of Hodgkin's disease in a child.


Prenatal care and delivery of the Rh negative patient.


Summary of remarks concerning physicians and government.


Extent of immunization on school entrance.


The evolution of our community hospital.


Neonatal hemorrhage.

Neonatal hemorrhage.


Hypnosis in painful terminal illness.

Hypnosis in painful terminal illness.


Complications of varicella.

Complications of varicella.


The problem of low back pain.

The problem of low back pain.


CONFERENCE on diseases of bones and joints.


Some unusual manifestations of bronchogenic carcinoma.


ARKANSAS public health at a glance selected causes of childhood mortality (0-19yrs.) Arkansas 1955-1957.


Selection and isolation of auxotrophic yeast mutants with the aid of antibiotics.


Fluorescent staining of Histoplasma capsulatum.


Cholesterol esterase activity of pleuropneumonialike organisms.


Effect of withholding glutamic acid and asparagine on the germination of spores of Bacillus subtilis.


D-sorbitol-6-phosphate dehydrogenase from Lactobacillus casei.


Nonacid-fast bacteria and HeLa cells: their uptake and subsequent intracellular growth.


A glutamic acid-producing bacillus.

A glutamic acid-producing bacillus.


Agar diffusion studies of group A streptococcal antigens.


Formation of tetanus toxin within the bacterial cell.


Isolation and fermentation characteristics of strains of Butyrivibrio from ruminal ingesta.


Determination of dehydrogenases in atypical strains and in other Mycobacteria.


Rapid production of complement fixation antigens for systemic mycotic diseases. I. Coccidioidin: influence of media and mechanical agitation on its development.


Quantitative adsorption of crystal violet by dead microorganisms.


Study of the purine metabolism of Staphylococcus aureus.


Studies of an enzyme produced by Bacillus fulminans that inactivates blood group O substance.


Effect of subtilin and nisin on the spores of Bacillus coagulans.


On the biosynthesis of pyocyanine.

On the biosynthesis of pyocyanine.


Methylnaphthalene oxidations by pseudomonads.


Growth enhancement of the Reiter treponeme by fatty acids.


Effect of metavanadate ion on the growth in vitro of Mycobacterium tuberculosis.


Substitution of known compounds for ascitic fluid in the cultivation of Borrelia vincentii.


Conversion of pteroylglutamic acid to the citrovorum factor by preparations from Lactobacillus casei.


Illegitimate combinations, Bacillus cereus var. terminalis and Bacillus coagulans var. thermoacidurans.


Effect of bacterial endotoxin on carbohydrate metabolism of animals.


Structure of Rhodomicrobium vannielii.

Structure of Rhodomicrobium vannielii.


[Data on intravenous cholangiocholecystography in surgery].


The standard dosimetre of the Rotterdamsch Radiotherapeutisch Instituut.


An electron microscopic study of the intestinal villus. I. The fasting animal. The structure of the intestinal villus of the rat was studied in thin sections of tissue fixed in buffered osmium tetroxide and embedded in methacrylate. The simple columnar epithelium investing the villus is surmounted by a striated border consisting of slender projections of the cell surface. These microvilli are arranged in almost crystalline, hexagonal array, and increase the apical surface area of the cell by a factor of 24. The core of each microvillus is filled with fine fibrils which arise from the filamentous substance of the terminal web underlying the striated border. Each microvillus is covered by a tubular extension of the plasma membrane of the epithelial cell. Pinocytotic vesicles originating from the plasma membrane occur at the bases of the intermicrovillous spaces. The nucleus, mitochondria, and the endoplasmic reticulum of the epithelial cell display no unusual features. Small bits of ergastoplasm occur in the apical cytoplasm. A thin basement membrane separates the epithelium from the lamina propria which consists of vessels, nerves, and numerous lymphocytes, eosinophiles, mast cells, plasma cells, smooth muscle fibers, and macrophages suspended in a delicate stroma of fibroblasts and collagen fibers. Intercellular fat droplets often occur in this stroma, even in animals fasted for 40 hours. The blood capillaries are distinguished by their extremely attenuated, fenestrated endothelial cells. The lacteal has a thicker endothelium which, although not fenestrated, appears to have significant interruptions, especially at the margins between neighboring lining cells. Strands of smooth muscle always accompany the lacteal but do not form an integral part of its wall. Unmyelinated nerves, many of which are too small to be distinguished with the light microscope, course through the lamina propria in association with the vessels. The nerve fibers evidently do not cross the basement membrane into the epithelium. Neuromuscular junctions or other terminal apparatus were not found.


An electron microscopic study of the intestinal villus. II. The pathway of fat absorption. The intestinal pathway for absorbed fat was traced in thin sections of intestinal villi from rats fed corn oil by stomach tube after a fast of 24 to 40 hours. For electron microscopy the tissues were fixed in chilled buffered osmium tetroxide and embedded in methacrylate. For light microscopy, other specimens from the same animals were fixed in formal-calcium, mordanted in K(2)Cr(2)O(7), and embedded in gelatin. Frozen sections were stained with Sudan black B or Sudan IV. About 20 minutes after feeding, small fat droplets (65 mmicro maximal diameter) appear in the striated border between microvilli. At the same time fat particles are seen within pinocytotic vesicles in the immediately subjacent terminal web. In later specimens the fat droplets are generally larger (50 to 240 mmicro) and lie deeper in the apical cytoplasm. All intracellular fat droplets are loosely enveloped in a thin membrane, the outer surface of which is sometimes studded with the fine particulate component of the cytoplasm. This envelope, apparently derived from the cell surface by pinocytosis, has at this stage evidently become a part of the endoplasmic reticulum. Just above the nucleus numerous fat droplets lie clustered within the dilated cisternae of the Golgi complex. As absorption progresses fat droplets appear in the intercellular spaces of the epithelium, in the interstitial connective tissue spaces of the lamina propria, and in the lumen of the lacteals. All of these extracellular fat droplets are devoid of a membranous envelope. The picture of fat absorption as reconstructed from these studies involves a stream of fat droplets filtering through the striated border, entering the epithelial cell by pinocytosis at the bases of the intermicrovillous spaces, and coursing through the endoplasmic reticulum to be discharged at the sides of the epithelial cell into extracellular spaces. From the epithelial spaces, the droplets move into the lamina propria and thence into the lymph. If the lumen of the endoplasmic reticulum is considered as continuous with the extracellular phase, then the entire pathway of fat absorption may be regarded as extracellular. However, it is impossible to evaluate from the electron microscopic evidence thus far available the quantitative importance of particulate fat absorption by the mechanism described.


The formation of intracellular crystals in midgut glands of Limnoria lignorum. Certain morphological features of intracellular crystal formation within the midgut glands of Limnoria lignorum (Rathke) have been studied with the electron microscope and cytochemical methods. A correlation has been established between Golgi membranes and formation of the crystals. The Prussian blue reaction reveals quantities of iron localized in the intracellular crystals and in small granular structures seen in the apical region of the cells. These granules can be identified as accumulations of Golgi membranes, with which iron-containing particles are associated. When these membrane configurations are studied with the electron microscope, they can be classified and arranged in an assumed sequence which is thought to represent successive stages in the development of crystals. As the membrane systems become progressively specialized, increasing accumulations of dense granular material appear within their interstices. This material is rich in iron and probably represents the component responsible for the positive Prussian blue reaction. This material also appears to be a precursor substance for iron-containing protein molecules which are synthesized and arranged to make up the crystals. These iron-containing molecules are first deposited in orderly array as double rows of dense particles on certain internal membranes of the specialized Golgi complexes. The membranes later disappear and the particles form definitive crystals by rearrangement into a hexagonal close-packed pattern.


An association between mitochondria and the endoplasmic reticulum in cells of the pseudobranch gland of a teleost. An elaborate and apparently unique specialization of the endoplasmic reticulum having the form of tubules and a precise orientation with respect to the mitochondria has been described for the specific cell of the pseudobranch gland. The tubules also are concentrated near the vascular border of the cell where they show continuity with the plasma membrane and open directly against the basement membrane. On the other side of the basement membrane, the endothelial cells of the sinusoid show openings or discontinuities characteristically associated with secretory cells. The pseudobranch gland is presumed to have carbonic anhydrase as one of its primary products, if not its only one, and the elaborate ultrastructure is thought to be associated with the special problems of secreting this enzyme.


Similarity of the structure of DNA from a variety of sources. DNA's from diverse cells of different species and from diverse tissues give the same x-ray diffraction pattern. The presently observable structure of DNA appears, then, to be the same in all cells. Thus, DNA in the resting state-the stored genetic material, from sperm of Paracentrotus lividus, Arbacia lixula, and salmon and from T(2) and T(7) bacteriophage-gives a pattern indistinguishable from DNA from very rapidly dividing cells, e.g., human acute leukemic leukocytes, human leukemic myeloid cells, mouse sarcoma 180, and bacteria-E. coli and pneumococci-during their logarithmic growth. The same x-ray patterns are given by DNA's from more slowly dividing tissues, e.g. calf liver, calf thymus, and human normal and leukemic lymphatic tissue. DNA from chicken erythrocytes-a DNA presumably metabolically inert-gives a similar picture. DNA's from several sources with a wide range in nitrogen base ratios, prepared independently by different workers using various methods, have given final products in varying yield; these all gave the same x-ray pattern, suggesting that all DNA is in the double-helical configuration. Finally, separation of the DNA molecule into a number of fractions with a varying adenine + thymine:guanine + cytosine ratio, but a constant adenine:thymine and guanine:cytosine ratio, each giving the same x-ray pattern as the original whole molecule, suggests that DNA cannot exist in significant amounts in forms other than the double-helix. X-ray diffraction photographs of sperm heads, extracted nucleoprotamine, calf thymus nuclei and extracted nucleohistone, and of chicken erythrocyte nuclei, are not all as well defined as those given by extracted DNA, but it is clear from the general characteristics of the pattern that much of the DNA bound to protein in these nuclei has the usual helical configuration, and that the double-helical structure of DNA exists in the cell and is not an artifact.


A cellular reaction to antibody in tissue culture studied with electron microscopy. The reaction of embryonic chick heart cells grown in tissue culture to specific guinea pig antiserum has been studied with electron microscopy. Heart fragments from chick embryos were cultured with a plasma clot. After being tested with antiserum or normal serum, they were fixed with buffered osmium tetroxide and embedded in butyl methacrylate before removal from the glass culture chamber. Thin cells found by phase microscopy to have reacted were sectioned in a plane parallel to the glass surface on which they had grown. The results confirm and extend observations made previously while the reactions were occurring. The plasma membrane, like that of the red cell, becomes disrupted or less resistant to trauma following the action of antiserum. The membranes of mitochondria and endoplasmic reticulum vesiculate and swell. Before nuclear shrinkage becomes prominent, the outer nuclear membrane separates over a large portion of the nuclear envelope and forms one or more large swollen blebs. Thus, the outer nuclear membrane shows a reactivity similar to endoplasmic reticulum. It is suggested that the various physical and chemical changes observed to follow the action of antibody and complement on fibroblasts may be explained by osmotic pressure differences between various cell components. Some basic similarities to the action of hemolytic agents on red cells are noted.


Studies on the control of mitotic activity in excised roots. I. The experimental system. The mitotic characteristics of excised roots of the garden pea, Pisum sativum, have been studied under conditions of controlled nutrition. The excised root system was tested with regard to its ability to respond, mitotically, to various carbon sources. Sucrose, glucose, fructose, and DL-glyceraldehyde were found to support mitotic activity in excised roots, galactose and 2-deoxy-D-glucose were toxic, and mannose ineffective. Initiation of mitotic activity in the presence of glucose was inhibited by the respiratory poisons, KCN and malonic acid, the uncoupling agent, 2,4-dinitrophenol, but was not notably affected by the protein synthesis inhibitor, chloramphenicol. The glucose-induced response in mitotic activity was not affected by the carcinogen, urethan, and indeed, there is some evidence that the response was actually enhanced. The fact that KCN, malonic acid, and probably 2,4-dinitrophenol, in suitable concentrations inhibit the onset of cell division suggests that some level of operation of the Krebs' cycle is essential for commission of cells into mitosis. Likewise, failure to inhibit cells in the process of active mitosis by KCN and malonic acid is not inconsistent with the idea that there is a shift from reliance on aerobic to anaerobic respiration between antephase and active mitosis.


The relation between protein synthesis and lipide accumulation in L strain cells and Ehrlich ascites cells. It has long been known that fat accumulates in old injured cells both in tissue culture and in many mammalian disease states. The use of L cells grown in suspension tissue culture permitted the opportunity to study conditions in which lipide accumulation could be retarded or accelerated. These cultures exhibit a three-phase growth curve which is similar to that previously found with bacteria and consists of a lag period, logarithmic growth period, and stationary period. Daily aliquots were removed from cultures going through these phases and protein and cholesterol content correlated with cell division. It was found that L cells gradually accumulated lipide in the cell concurrent with retardation of cell division and protein synthesis. Conversely old lipide-laden cells, placed in fresh media and encouraged to active division with net protein synthesis progressed from a high to a low lipide/cell ratio over a period of 2 to 4 days. An amino acid analogue p-fluorophenylalanine and a mitotic inhibitor, colchicine, also markedly increased the lipide/cell ratio. Similar results were found in in vitro experiments with Ehrlich ascites cells.


The development of the cnidoblasts of Hydra; an electron microscope study of cell differentiation. The general histological organization of Hydra is reviewed and electron microscopic observations are presented which bear upon the nature of the mesoglea, the mode of attachment of the contractile processes of the musculo-epithelial cells, and the cytomorphosis of the cnidoblasts. Particular attention is devoted to the changes in form and distribution of the cytoplasmic organelles in the course of nematocyst formation. The undifferentiated interstitial cell is characterized by a small Golgi complex, few mitochondria, virtual absence of the endoplasmic reticulum, and a cytoplasmic matrix crowded with fine granules presumed to be ribonucleoprotein. These cytological characteristics persist through the early part of the period of interstitial cell proliferation which leads to formation of clusters of cnidoblasts. With the initiation of nematocyst formation in the cnidoblasts, numerous membrane-bounded vesicles appear in their cytoplasm. These later coalesce to form a typical endoplasmic reticulum with associated ribonucleoprotein granules. During the ensuing period of rapid growth of the nematocyst the reticulum becomes very extensive and highly organized. Finally, when the nematocyst has attained its full size, the reticulum breaks up again into isolated vesicles. The Golgi complex remains closely applied to the apical pole of the nematocyst throughout its development and apparently contributes to its enlargement by segregating formative material in vacuoles whose contents are subsequently incorporated in the nematocyst. The elaboration of this complex cell product appears to require the cooperative participation of the endoplasmic reticulum and the Golgi complex. Their respective roles in the formative process are discussed.


The occurrence of intercellular bridges in groups of cells exhibiting synchronous differentiation. A previous electron microscopic study of the cat testis revealed that spermatids derived from the same spermatogonium are joined together by intercellular bridges. The present paper records the observation of similar connections between spermatocytes and between spermatids in Hydra, fruit-fly, opossum, pigeon, rat, hamster, guinea pig, rabbit, monkey, and man. In view of these findings, it is considered likely that a syncytial relationship within groups of developing male germ cells is of general occurrence and is probably responsible for their synchronous differentiation. When clusters of spermatids, freshly isolated from the germinal epithelium are observed by phase contrast microscopy, the constrictions between the cellular units of the syncytium disappear and the whole group coalesces into a spherical multinucleate mass. The significance of this observation in relation to the occurrence of abnormal spermatozoa in semen and the prevalence of multinucleate giant cells in pathological testes is discussed. In the ectoderm of Hydra, the clusters of cnidoblasts that arise from proliferation of interstitial cells are also connected by intercellular bridges. The development of nematocysts within these groups of conjoined cells is precisely synchronized. Both in the testis of vertebrates and the ectoderm of Hydra, a syncytium results from incomplete cytokinesis in the proliferation of relatively undifferentiated cells. The intercellular bridges between daughter cells are formed when the cleavage furrow encounters the spindle remnant and is arrested by it. The subsequent dissolution of the spindle filaments establishes free communication between the cells. The discovery of intercellular bridges in the two unrelated tissues discussed here suggests that a similar syncytial relationship may be found elsewhere in nature where groups of cells of common origin differentiate synchronously.


The cytological localization of intracellular neuronal acetylcholinesterase. Sections of cat ciliary ganglia were stained for acetylcholinesterase activity by several modifications of the acetylthiocholine method in order to achieve optimal accuracy of cytological localization of the enzyme. These were compared by ordinary light and phase contrast microscopy with similar sections stained by standard techniques for Nissl substance, the Golgi apparatus, and the neurofibrillae, and by intravital methylene blue. The pattern of cytoplasmic distribution of acetylcholinesterase corresponded most closely with that of the Nissl substance. Following total inactivation of the ganglionic acetylcholinesterase by intravenously administered di-isopropyl fluorophosphate, the reappearance of the enzyme in vivo occurred at the same cytoplasmic sites prior to its reappearance at the cell membrane or preganglionic axonal terminations. These observations, and reports cited from the literature, provide support for the hypothesis that acetylcholinesterase is synthesized within the endoplasmic reticulum, then transported via its canaliculi to the surface of the cell and its processes, where its functional sites are oriented externally to the lipoidal membrane.


The metabolism of chromosomal ribonucleic acid in Drosophila salivary glands and its relation to synthesis of desoxyribonucleic acid. Incorporation of adenine-8-C(14) into chromosomal nucleic acids of Drosophila salivary glands has been observed with the autoradiographic technique. RNA-C(14) and DNA-C(14) were detected as the fractions extractable by ribonuclease digestion and resistant to ribonuclease, respectively. Extractions with desoxyribonuclease and acids were also used to identify the nucleic acids. Time-course curves were determined from grain counts. RNA-C(14) concentration reached a maximum in 2 hours, and decreased after the 4th hour. DNA-C(14) concentration reached its maximum within 8 hours, and showed no decreases during a 48-hour experiment. In the latter part of the period of observation, morphological differentiation of the gland occurred, the decrease in RNA-C(14) became very rapid, and a large increase in DNA-C(14) was observed. Marked decrease in RNA-C(14) and increase in DNA-C(14) were detectable in a few hours when isotope was administered shortly before visible differentiation of the gland. Measurements of nuclear size indicated no significant decreases in RNA-C(14) amount prior to the period of differentiation. During this later period, a large decrease in RNA-C(14) amount occurs suddenly, and the same amount of C(14) is added simultaneously to the DNA fraction, as expected if RNA-C(14) is utilized in the synthesis of DNA.


The effect of respiratory inhibitors and chelating agents on the frequencies of chromosomal aberrations produced by x-rays in Vicia. Nitrosophenylhydroxylamine-ammonium (cupferron), potassium cyanide, sodium azide, ethylenediaminetetraacetate (EDTA), alpha,alpha'-dipyridyl, and o-phenanthroline were tested (1) for their ability to enhance the frequencies of chromosomal aberrations produced by x-rays in the root tip cells of the broad bean, Vicia faba, and (2) for their ability to inhibit oxygen consumption of excised roots of the same plant. In all cases a close correlation was found between the inhibitory effect on respiration and the enhancement of the sensitivity to x-rays at low oxygen pressures. EDTA, dipyridyl, and o-phenanthroline did not affect respiration to any greater extent, and they were without influence on the radiosensitivity. Cyanide, azide, and cupferron, which strongly inhibited respiration, also increased the frequencies of chromosome aberrations produced by x-rays at low oxygen pressures. The relation between oxygen concentration and radiosensitivity was determined both in the presence and the absence of the respiratory inhibitor cupferron. When cupferron was present, the radiosensitivity was influenced by oxygen concentrations 30 times lower than those effective in the absence of the inhibitor. In an atmosphere of pure oxygen, an increase of radiosensitivity of about 20 per cent was obtained with cupferron, EDTA, and potassium cyanide.


The endoplasmic reticulum and the Golgi structures in maize root cells. Maize root tips were fixed in potassium permanganate, embedded in epoxy resin, sectioned to show silver interference color, and studied with the electron microscope. All the cells were seen to contain an endoplasmic reticulum and apparently independent Golgi structures. The endoplasmic reticulum is demonstrated as a membrane-bounded, vesicular structure comparable in many aspects to that of several types of animal cells. With the treatment used here the membranes appear smooth surfaced. The endoplasmic reticulum is continuous with the nuclear envelope and, by contact at least, with structures passing through the cell wall. The nuclear envelope is characterized by discontinuities, as previously reported for animal cells. The reticula of adjacent cells seem to be in contact at or through the plasmodesmata. Because of these contacts the endoplasmic reticulum of a given cell appears to be part of an intercellular system. The Golgi structures appear as stacks of platelet-vesicles which apparently may, under certain conditions, produce small vesicles around their edges. Their form changes markedly with development of the cell.


An electron microscope study of myelin figures. In the electron microscope, thin sections of OsO(4)-fixed myelin figures from the phospholipide fraction of human brain show a pattern of parallel dark lines with a repeating period of about 40 A. It is shown that the dark lines probably represent the reaction product of OsO(4) with double bonds in the fatty acid chains, thereby marking the central portion of one bimolecular lamella. The addition of globin results in dense lines 25 to 50 A wide that cover the surface of the myelin figures. When such a figure consists of only two bimolecular leaflets of lipide covered with globin, the structure shows striking similarity to the image of cell membranes in fixed tissue sections. A hypothetical schema is given of the molecular structure of the figure, and the distribution of OsO(4) in it.


Knives of high silica content glass for thin-sectioning.


Dense granule in the elementary body of molluscum contagiosum.


A device for staining tissue sections for electron microscopy.


Primary tendon repair.

Primary tendon repair.


A rapid method for localization of tissue structures or lesions for electron microscopy.


The management of tendon injuries.

The management of tendon injuries.


Why tendon repair.

Why tendon repair.


Primary tendon repairs; a study of 789 consecutive tendon severances.


Anatomical considerations in the primary treatment of tendon injuries of the hand.


Excision of the greater multangular bone as an adjunct to mobilization of the thumb.


The carpal-tunnel syndrome; a clinical and anatomical study.


Dupuytren's contracture; a new concept of the pathogenesis correlated with surgical management.


Reconstructive arterial surgery in upper-extremity injuries.


Reconstruction of congenital abnormalities of the upper extremities.


Thrombofibrosis of the ulnar artery in the palm.


Circulation of the hand, injection-corrosion studies.


Arthroplasty of the hip in rheumatoid arthritis; a follow-up study of sixty-eight hips.


The measurement of hip motion in the sagittal and coronal planes.


Spectrochemical determination of trace metals in normal striated muscle in the rabbit.


Active shoulder motion in complete deltoid paralysis.


Fracture-dislocation of the ankle; an unusual cause of failure of reduction; a case report.


A hip-nailing ruler.

A hip-nailing ruler.


Effects of rotatory and valgus malpositions on blood supply to the femoral head; observations at arthroplasty.


Bone and joint changes following burns; a roentgenographic study; preliminary report.


Rheumatoid synovial cyst of the hip; report of three cases.


Results of treatment of congenital dislocation of the hip.


Congenital muscular torticollis in infancy; some observations regarding treatment.


The prenatal development of the skeleton and joints of the human foot.


Frozen-shoulder syndrome in patients with pulmonary tuberculosis.


Final report of the Committee for the study of femoral-head prostheses.


Surgical treatment of congenital dislocation of the hip in children; a one-stage procedure.


A clinical comparative study of autogenous and homogenous-bone grafts.


Treatment of giant-cell tumor of bone.

Treatment of giant-cell tumor of bone.


Lumbosacral anomalies.

Lumbosacral anomalies.


Chronic neurological sequelae of acute trauma to the spine and spinal cord. III. The syndrome of chronic injury to the cervical spinal cord in the region of the central canal.


Localization of alkaline phosphatase in the histogenesis of cartilage and bone.


Osteoid osteoma of a cervical vertebra; report of a case.


Metaphyseal chondrodysplasia of Jansen.

Metaphyseal chondrodysplasia of Jansen.


ORTHOPAEDIC Research and Education Foundation.


Some problems of mental health in India.


The future of the Christian hospital in Indian.


Endocrines in obstetrical and gynaecological practice.


Spontaneous regression of reticulum-cell sarcoma of bone; a case report.


Isolated rectum as an artificial bladder.


Eye lesions in diabetes.

Eye lesions in diabetes.


Simple hospital call bell system.

Simple hospital call bell system.


The responsibility of a Christian hospital.


Tricks of the trade-in the clinic.

Tricks of the trade-in the clinic.


Oral hypoglycaemic agents.

Oral hypoglycaemic agents.


Relationship between malnutrition and bladder stones.


Recent oral antidiabetics.

Recent oral antidiabetics.


Myasthenia gravis in children.

Myasthenia gravis in children.


A case of hypersplenism with unusual presentation.


Report of tetanus at Wanless hospital.

Report of tetanus at Wanless hospital.


Some aspects of ophthalmic nursing.

Some aspects of ophthalmic nursing.


Impressions of our tour in the U.S.A.

Impressions of our tour in the U.S.A.


A simple grease trap.

A simple grease trap.


On the methodology of investigations of etiologic factors in chronic diseases.


Inborn disorders of metabolism.

Inborn disorders of metabolism.


On the methodology of investigations of etiologic factors in chronic diseases: some comments.


A controlled study of chlorothiazide as a diuretic agent; with a note on untoward reactions in the presence of renal insufficiency.


An evaluation of two new analgesics (dextromoramide and racemoramide) in healthy subjects and in patients with chronic pain.


Some remarks on the management of late syphilis.


Sulfation factor activity of sera from patients with pituitary disorders.


The effect of iproniazid on the rehabilitation of disabled persons with low motivation.


Metabolic changes produced by human growth hormone (Li) in a pituitary dwarf.


The effect of betaine on human serum lipoproteins.


Effects of estrogen and testosterone on circulating thyroid hormone.


Coexistence of Addison's disease and diabetes mellitus: report of three cases with a discussion of metabolic interrelationships.


Changes in diabetes insipidus during pregnancy and lactation.


Identification of substance S in human adrenal venous blood.


Urinary excretion of beta-cortolone (3 alpha, 17 alpha, 20 beta, 21-tetrahydroxypregnane-11-one) in young and elderly men and women.


The preparation of an apparently homogeneous gonadotropin from human menopausal urine.


Separation of human thyrotropin from plasma by ion exchange chromatography.


The effects of hypophysectomy on certain parameters of thyroid function in two patients with Graves' disease.


Congenital adrenal hyperplasia and precocious gonadotropin secretion in a 6-year-old girl.


Effect of chorionic gonadotropin on urinary excretion of 17-ketosteroids in a 10-year-old girl with congenital adrenal hyperplasia.


Urinary 17-ketosteroids in surgical stress.


The interpretation of steroid half-life values.


The acid mucopolysaccharide and 5-hydroxytryptamine content of human thrombocytes in rheumatoid arthritic and nonarthritic individuals.


Studies of antiricketic activity in sera from patients with disorders of calcium metabolism and preliminary observations on the mode of transport of vitamin D in human serum.


The maintenance of a sustained thrombolytic state in man. II. Clinical observations on patients with myocardial infarction and other thromboembolic disorders.


The mechanism of clot dissolution by plasmin.


The differential response of the adrenal cortex and medulla to bacterial endotoxin.


Red cell, plasma and blood volume in healthy men measured by radiochromium (Cr51) cell tagging and hematocrit: influence of age, somatotype and habits of physical activity on the variance after regression of volumes to height and weight combined.


Relationship between a range of tissue temperature and local oxygen uptake in the human forearm. III. Changes observed after anaerobic work, in the postexercise period.


Experimental potassium depletion in normal human subjects. I. Relation of ionic intakes to the renal conservation of potassium.


Studies of the dipyrrylmethene ("fuscin") pigments. I. The anabolic significance of the fecal mesobilifuscin.


Experimental potassium depletion in normal human subjects. II. Renal and hormonal factors in the development of extracellular alkalosis during depletion.


The maintenance of a sustained thrombolytic state in man. I. Induction and effects.


Hematologic studies on psychotic patients under chlorpromazine medication.


Studies of the dipyrrylmethene ("fuscin") pigments. II. The contrasting ratios and significance of the fecal urobilinogen and mesobilifuscin in certain anemias.


The effect of changes in ventilation and pulmonary blood flow on the diffusing capacity of the lung.


Left ventricular function at rest and during exercise.


Variability in absorption of insulin-I 131 in normal and diabetic subjects after subcutaneous and intramuscular injection.


Changes in renal concentrating ability produced by parathyroid extract.


Psychological response to d-lysergic acid diethylamide and its relationship to adrenochrome levels.


A synergistic action of prochlorperazine and mepazine in two cases of schizophrenia.


Hematogenous pyelonephritis in rats. IV. Relationship of bacterial species to the pathogenesis and sequelae of chronic pyelonephritis.


Follow-up evaluation on a controlled, blind study of effects of chlorpromazine on psychotic behavior.


A nascent somatic delusion treated psychotherapeutically by a confrontation technique.


The effect of protein depletion on the distribution of protein synthesis in the dog.


Effect of cholesterol synthesis inhibition in normocholesteremic young men.


Estimation of pulmonary resistance by repetitive interruption of airflow.


Psychologists in administration.

Psychologists in administration.


The psychologist as administrator.

The psychologist as administrator.


Administrative opportunities for psychologists in state mental health programs.


Personnel problems of psychologists in mental health administration.


Administrative issues for the psychologist as director of a community guidance center.


The administrative role of chief psychologist in a medical setting.


An operational approach to the diagnosis of levels of personality integration or psychopathology.


The psychiatric attitudes battery: a procedure for assessing attitudes towards psychiatric treatment and hospitals.


Life history correlates of delinquent and psychopathic behavior.


The questionable validity of some assumed antecedents of mental illness.


Multidisciplinary views on the preparation of written clinical psychological reports. II. Acceptability of certain common content variables and styles of expression.


The comparative effects of brain damage on the Halstead impairment index and the Wechsler-Bellevue scale.


A short screening test for organic deficit.


Predicting potential intelligence.

Predicting potential intelligence.


A comparison of the coloured progressive matrices (CPM) with the Wechsier adult intelligence sclae (WAIS) in a normal aged white male population.


Maternal attitudes and children's intelligence.


Tables to facilitate the comparison of sub-test scores on the WISC.


Relation of manifest anxiety to specific problem areas.


A comparative analysis of selected Guilford-Zimmerman temperament survey scales with the Taylor manifest anxiety scale.


Defensiveness and unwitting self-evaluation.


Manifest anxiety in hospitalized children.


A research note on the K scale of the MMPI and deensiveness.


Treat and direction of aggression.

Treat and direction of aggression.


The validity of the Taulbee-Sisson MMPI scale pairs in female psychiatric groups.


A validity test of self-ideal discrepancy.


A clinical evaluation of Eysenck's objective Rorschach.


Influence of social desirability upon Rorschach content.


A study of incidental stimulus values in the Szondi test.


Clinical psychologists' diagnostic utilization of human figure drawings.


The projection of hostility on the Rorschach and Thematic Stories Test.


The effect of arbitrary termination on return to psychotherapy.


The relationship between TAT responses and leaving-the-field behavior.


The new principle of psychotherapy.

The new principle of psychotherapy.


A homosexual treated with rational psychotherapy.


Social status and clinic contact.

Social status and clinic contact.


Initial complaints as predictors of continuation in psychotherapy.


Auditory interference with digit span performance.


Cerebellar stimulation in the unanesthetized bullfrog.


The behavioral effects of destructive lesions of the periaqueductal gray matter in adult cats.


Origin of ciliary ganglia in the chick.

Origin of ciliary ganglia in the chick.


Studies on the relationship between ovarian hormones and uterine infection. II. The effect of ovarian hormones on the antibacterial activity of the uterine environment.


On the functional connections of single units in the central nervous system of the crayfish, Procambarus clarkii Girard.


Studies on the relationship between ovarian hormones and uterine infection. I. The effect of ovarian hormones on the bactericidal activity of blood plasma.


The termination of primary vestibular fibers in the vestibular nuclei in the cat; an experimental study with silver methods.


Studies on the relationship between ovarian hormones and uterine infection. III. The role of the antibody system in uterine defence.


The spermicidal activity of hydrogen peroxide in vitro and in vivo.


Neurohypophysial hormones and release of gonadotrophins.


The metabolism of 4-14C prednisolone.

The metabolism of 4-14C prednisolone.


The effect of hypophysectomy on the mouse uterine response to gonadotrophins.


The significance of changes in plasma cortisol concentration and renal excretion of corticosteroids after a water load.


The effects of steroid sex hormones on pregnant rats.


Experimental cryptorchidism in rabbits: the response of spermatozoa in the tail of the epididymis.


Section of the pituitary stalk in monkeys.


A study of the natural history of diabetes in an English community.


Ribonucleic acid content and number of liver nuclei after adrenalectomy.


Timing of the stages of the maturation divisions, ovulation, fertilization and the first cleavage of eggs of adult mice treated with gonadotrophins.


Endocrine disturbances of pregnancy and foetal pathology.


Goitre due to dyshormonogenesis.

Goitre due to dyshormonogenesis.


The P.T.C. taste response in thyroid disease.


Genetic factors in inter-sexes.

Genetic factors in inter-sexes.


The effect on adrenocortical function in man of 1, 2-bis-(3-pyridyl)-2-methyl-1-propanoneditartrate (SU 4885).


Biological effects of compounds related to amphenone.


Growth in the young hypophysectomized guineapig.


The identification of pregnanediol in liquor amnii, bile and faeces.


Some physiopathological parameters of natural resistance to infection in murine salmonellosis. Susceptible (BSVS) and resistant (BRVR) mice were experimentally infected with Salmonella typhimurium. The double strain inoculation technique was used in which both avirulent and virulent representatives of S. typhimurium were admitted into the hosts. The BSVS mice succumbed without exception while the BRVR mice survived to 52 per cent. No deaths occurred during the experimental period in non-infected control mice. Parallel to the survivorship test, and concurrent with it, the activity of the reticulo-endothelial system (RES) was measured at frequent intervals in identically infected BSVS and BRVR mice and in their non-infected controls. For this measurement the carbon clearance method was used. No pre-infection difference of activity of the RES could be discerned in susceptible BSVS mice vs. resistant BRVR. Following infection, increases in the RES activity were detected in about the same magnitude in both mouse stocks. However, a difference was found in the time of onset. The susceptible animals showed an early and short increase in the activity of the RES, followed by a drop to control levels at the time of death. The resistant group exhibited a considerably delayed, but significant increase in RES activity, which returned to control levels approximately 4 weeks after infection. The absolute white blood count did not undergo significant change in either of the two infected groups, but the susceptible animals showed a relative increase of their neutrophils at the expense of their lymphocytes. Extensive anatomical changes were observed in both mouse strains, mainly confined to liver and spleen. These consisted of stasis, swelling of Kupffer cells, necrotic foci, histiocytic-monocytic nodules, widespread thrombosis of branches of the portal and splenic veins, and extensive areas of necrosis. These changes appeared earlier in susceptible than in resistant animals. The implications of these findings are discussed.


Macroglobulinemia. III. The effect of mercaptoethanol on the antigenic structure of macroglobulins. The monomers obtained by treating gamma(1)-macroglobulins with mercaptoethanol have proved to be antigenically different from normal 7S 7gamma-globulin. The depolymerization of the macroglobulins resulted in the loss of several antigenic determinants, although the monomers still cross-reacted with antisera against macroglobulins. Reaggregation of the monomers occasionally resulted in the reconstitution of some or all of the antigenic determinants that were lost during depolymerization. Repeated freezing and thawing of pathological macroglobulins in iodoacetate resulted in their complete antigenic destruction. Repeated freezing and thawing of one of the monomers in excess iodoacetate resulted in the degradation to a protein antigenically indistinguishable from Bence Jones protein. The other two monomers studied were stable under these conditions.


The mammalian cell-virus relationship. IV. Infection of naturally insusceptible cells with enterovirus ribonucleic acid. Ribonucleic acid extracted with phenol from Type 1 poliovirus, Coxsackie A-9, Coxsackie B-1, and ECHO 8 viruses infected non-primate cells and animals insusceptible to whole virus as such. Viral RNA was proved infectious for insusceptible cells in test systems of established cell lines, primary monolayer cultures, Maitland type cultures, and living animals inoculated intracerebrally. Cells of rabbit, swine, mouse, guinea pig, chicken, and hamster were infected. Each virus produced was identical with the virus donating RNA, in (a) neutralization by homotypic antiserum, (b) resistance to ribonuclease treatment, and (c) failure to be adsorbed or replicated by nonprimate cells, even of the strain producing the virus from RNA. Produced virus was adsorbed and replicated by susceptible primate cells as usual. Virus in RNA-infected cell cultures was produced in a single cycle unaccompanied by overt cytopathic effect on non-primate cells or disease of intracerebrally inoculated animals. By drastic elution of infective poliovirus associated with rabbit cells exposed to massive inocula of intact virus, intact poliovirus was shown to infect insusceptible non-primate cells to produce progeny indistinguishable from the parent virus population. Under these conditions, infection was accomplished by about 10 virus plaque-forming units per billion inoculated.


The effect of high doses of x-irradiation on the phagocytic, proliferative, and metabolic properties of the reticulo-endothelial system. The effect of moderately high doses of x-irradiation upon the reticulo-endothelial system of mice and rats was investigated. A dosage of 600 r to mice and 850 r to rats did not interfere with the ability of the RES to clear colloidal particles from the blood. However the 850 r x-ray dose to rats prevented recovery of normal phagocytic function after "blockade." In mice, 600 r interfered with the ability of the RES to respond to the usual stimulating effect of zymosan. The ability of the RES of mice which have received 600 r of x-rays to clear P(32)-labelled E. coli from the blood was not significantly altered. These mice responded poorly to immunization, as demonstrated by the slow rate of clearance of the bacteria from the blood of immunized, irradiated individuals as compared with that of immunized controls. This reflected the lowered antibody production and not deficiency of phagocytic mechanism. There was no evidence of a changed capacity of the Kupffer cells of mice which had received 600 r of x-rays to break down denatured protein enzymatically.


A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and Staphylococci by the reticuloendothelial system. 1. The clearance of P(32)-labelled heat-killed E. coli and staphylococci from the blood follows an exponential function of the time, and the bacteria are phagocytized principally by the RES of the liver and spleen. 2. The rates of clearance of equivalent number of E. coli from the blood is rapid in rabbits and slow in mice and appears to be related to the level of antibodies in the serum of these animals. 3. Unlike E. coli, staphylococci are cleared rapidly and efficiently by the RES from the blood of mice which have a sufficient level of serum antibody against these bacteria. 4. The numbers of bacteria, phagocytized by the liver or the spleen respectively, depend upon the rate of clearance and the extent of opsonization of the bacteria. Rapidly cleared, well opsonized E. coli are removed almost exclusively by the liver, while less efficiently phagocytized bacteria are also cleared by the spleen in large numbers. 5. The rate of clearance of E. coli and the efficiency with which they are phagocyted by the RES in mice have been shown to be directly related to the level of antibody in the serum. 6. Treatment of mice with S. typhi or Serratia marcescens endotoxins increases the rate of clearance of E. coli from the blood and the level of antibody against E. coli in the serum. The enhanced clearance of E. coli can be transferred to normal mice by the serum of endotoxin-treated mice.


Studies of mouse polyoma virus infection. IV. Evidence for mucoprotein erythrocyte receptors in polyoma virus hemagglutination. Treatment of guinea pig erythrocytes with types A and B influenza viruses rendered them inagglutinable by polyoma virus; also, the inhibitory effect of ovomucin on polyoma virus hemagglutination was destroyed by pretreatment of the ovomucin with various myxoviruses. These results indicate that polyoma virus and myxovirus erythrocyte receptor sites are identical. However, no destruction by polyoma virus of its own or of myxovirus receptors or inhibitors was detected. No serologic relationship was detected between polyoma virus and members of the myxovirus group; differences in size and stability further indicate their distinctness. No evidence was found of biologic or serologic relationship of polyoma virus with encephalomyocarditis virus or mouse encephalomyelitis virus.


Isotonicity of liver and of kidney tissue in solutions of electrolytes. Solutions of a wide variety of electrolytes, isotonic with liver or with kidney tissue, have approximately the same osmotic pressure as solutions of sodium chloride isotonic with tissues of the two organs respectively; that is, with solutions approximately twice as concentrated as the sodium chloride of mammalian blood plasma. The molar concentration of various electrolytes isotonic with liver or with kidney tissue immediately after its removal from the body is determined by the molecular weight, valency, and ion-dissociation of these electrolytes in accordance with the well known conditions of osmosis. The plasma membranes of liver and of kidney cells are imperfectly semipermeable to electrolytes, and those that enter the cell, though retarded in so doing, bring about injury which increases permeability to water. The osmotic activity of cells of mammalian liver and kidney immediately after their removal from the body resembles that of plant cells, egg cells of marine invertebrates, and mammalian red blood corpuscles and presumably represents a basic property of living cells by which osmotic pressure may be adjusted to functional need.


Performance in differential conditioning and discrimination learning as a function of hunger and relative response frequency.


On the prediction of occurrence of particular verbal intrusions in immediate recall.


A comparison of three varieties of training in human problem solving.


Reaction time and EEG activation under alerted and nonalerted conditions.


Studies on the hemolysis of red blood cells by mumps virus. IV. Quantitative study of changes in red blood cell lipides and of virus lipides. Hemolysis of chicken red blood cells by mumps virus is associated with the release of sphingomyelin from the stromal lipoprotein and the destruction of 65 per cent of the sphingomyelin of the red cell stroma. However, the virus had no effect on isolated phosphatides extracted from the erythrocytes. The hemolytic action of the virus and changes in sphingomyelin content of the erythrocytes fail to occur at a pH of 6.0. The viral hemolysis of human erythrocytes is not associated with similar alterations in their content of sphingomyelin. The absence of lecithin from sheep erythrocytes, which are also lysed by mumps virus, is additional evidence that a viral lecithinase is not associated with the hemolytic property of mumps virus. Mumps virus concentrated from the amniotic fluid of viral infected chick embryos contains about 7 per cent phosphatide, 60 per cent of which is sphingomyelin.


Intracellular survival of staphylococci. A tissue culture procedure is described which permits the quantitative evaluation of the intracellular survival of staphylococci within leucocytes. Staphylococcus aureus survived, but did not multiply, within neutrophils and monocytes of normal rabbits. The same was true of normal human blood leucocytes. Staphylococcus albus on the other hand was destroyed by these cells under the same conditions. Rat monocytes destroyed S. aureus and S. albus with equal facility. Although most experiments were carried out in the presence of 50 microg. streptomycin/ml., similar results were obtained without the use of this antibiotic. The applications of the tissue culture procedure with regard to studies on virulence and immunity in staphylococcal disease are discussed.


Reversal and nonreversal shifts in kindergarten children.


Aftereffect of a moving pattern.

Aftereffect of a moving pattern.


The relationship between probability difference, (pi1-pi2), and learning rate in a contingent partial reinforcement situation.


Experimental pulmonary Pneumocystis carinii infection in rabbits. Moderate to marked interstitial pneumonitis with many Pneumocystis organisms was found in rabbits treated with cortisone and antibiotics and instilled intranasally with a suspension of lung tissue from either a patient or a rabbit with this infection. Organisms and pulmonary lesions of similar severity and frequency were present in controls treated in the same manner but instilled with either saline or a boiled suspension of normal human lung tissue. The administration of antibiotics and infected rabbit lung suspension only produced less marked lung changes with fewer organisms. Rare organisms and minute foci of pneumonitis were encountered in normal rabbits which had received neither hormone, antibiotics, nor inoculum. The pulmonary lesions in the cortisone-treated rabbits resembled closely the findings in patients with the subclinical form of Pneumocystis pneumonitis. They did not reproduce the massive lesions of widespread Pneumocystis pneumonia in infants. The findings indicate that latent pulmonary Pneumocystis infection was widespread in these rabbits but do not establish the transmission of the disease. The activation of latent infection was dependent on an impairment of host resistance which in these experiments was produced most effectively by the administration of cortisone. The differences between the experimental lesions and those of typical Pneumocystis pneumonia in infants suggest that in man an unknown defect of host defenses other than that induced by prolonged hormone administration accounts for the increased susceptibility to the infection. It is concluded that in the presence of widespread latent Pneumocystis infection the development of active disease is a manifestation of altered host resistance.


Absolute judgments of odor intensity.

Absolute judgments of odor intensity.


Studies on the immunochemistry of human low density lipoproteins utilizing an hemagglutination technique. Hemagglutination is a specific and sensitive technique for investigating the purity of lipoproteins and the immunologic relationships between low density lipoprotein fractions. The S(f) 10-400 and S(f) 3-9 lipoprotein fractions, isolated from human serum by dextran sulfate-density gradient centrifugation procedure and repurified by centrifugation appeared to contain only lipoprotein antigens since these fractions did not stimulate the production of antibodies against other serum proteins. Cross-absorption experiments with lipoproteins carried on "tanned" cells demonstrated that the S(f) 3-9 lipoprotein fraction contains all the antigenic components of the S(f) 10-400 lipoprotein fraction together with additional antigenic components not found in the S(f) 10-400 lipoprotein fraction. Thus S(f) 3-9 and S(f) 10-400 lipoprotein fractions are immunologically similar but not identical. Low density lipoproteins contain no antigens in common with the high density lipoproteins. An S(f) 3-9 antiserum can be used to detect both S(f) 3-9 and S(f) 10-400 antigens. The S(f) 3-9 lipoprotein fraction used as an antigen will detect antibodies against both S(f) 3-9 and S(f) 10-400 lipoprotein fractions. The S(f) 3-9 and S(f) 10-400 antisera did not contain immune antibodies against erythrocytes of the different blood groups or against sheep, guinea pig, dog, calf, pig, horse, and chicken erythrocytes. Normal subjects and subjects with recent myocardial infarctions had no circulating autoantibodies against the S(f) 3-9 and S(f) 10-400 lipoprotein fractions.


Motion parallax as a determinant of perceived depth.


The nature of the immunologic inadequacy of neonatal rabbits. II. Antibody formation by neonatal splenic cells transferred to adult recipients. It has been shown that cells from neonatal rabbits are capable of producing considerable amounts of antibody after exposure to antigen in vitro and transfer to x-radiated adult recipients. This suggests that the immunological inadequacy of these neonates is not dependent primarily upon the lack of cells capable of antibody formation. Both in vitro sensitized neonatal lymphoid cells and in vivo sensitized adult lymphoid cells made much more antibody after transfer to x-rayed adult recipients than to neonatal recipients. Possible reasons for and significance of these observations are pointed out in the discussion.


Effect of magnitude of reinforcement on acquisition and extinction of a running response.


An evaluation of the manifest anxiety scale by the use of electromycography.


Response learning in paired-associated lists as a function of intralist similarity.


The effect of differential onset time on the conditioned response strength to elements of a stimulus complex.


The effect of precision, delay, and schedule of knowledge of results on performance.


Studies on a toxin-inactivating substance excreted by Penicillium cyaneo-fulvum.


Acquisition, extinction, and counterconditioning with different verbal reinforcement combinations.


Purification and properties of a polymetaphosphatase from Corynebacterium xerosis.


The influence of phosphorus on the development of Streptomyces aureofaciens and on its ability to produce chlortetracycline.


The fine structure of the yeast-like cells of Histoplasma in culture.


Gene controlled resistance and sensitivity to caffeine and nicotine in Saccharomyces.


Synthesis and breakdown of poly-beta-hydroxybutyric acid by bacteria.


A survey of heterotrophic micro-organisms from soil for ability to form nitrite and nitrate.


Localization of enzymes in Bacillus megaterium, strain M.


Growth idiosyncrasies of some Bordetella pertussis strains, and the intracerebral virulence of these strains in mice.


A replica plating technique for the isolation of nutritionally exacting mutants of a filamentous fungus (Aspergillus nidulans).


A dextran-fermenting organism from the rumen closely resembling Lactobacillus bifidus.


Observations on the assay of vitamin B6 with Saccharomyces carlsbergensis 4228.


The formation of keto and amino acids by Mycobacterium butyricum growing in a chemically defined medium.


Inter-relationships of serine, glycine and vitamin B6 in the growth of mutants of Escherichia coli.


The synthesis of vitamin B6 by some mutant strains of Escherichia coli.


Effects of extracts of blue-green algae on pigment production by Serratia marcescens.


Changes in the phage-typing patterns of staphylococci following lysogenization.


Changes in typing pattern of phage-type 80 staphylococci.


Effect of temperature on natural mutation in Escherichia coli.


A study of some enzymes in extracts of a non-capsulated strain of pneumococcus concerned with uridine pyrophosphoglycosyl metabolism.


The effect of non-lethal deflagellation on bacterial motility and observations on flagellar regeneration.


Factors affecting the toxicity of solanine and related alkaloids to Fusarium caeruleum.


The growth-promoting activity of compounds of the vitamin K group and analogues for a rumen strain of Fusiformis nigrescens.


Comparison of the early stages of infection by tobacco mosaic virus and its nucleic acid.


A continuous flow method for the determination of glucose uptake by excised rat diaphragm. A technique is described for the determination of the rate of uptake of glucose by the excised rat diaphragm preparation at intervals as short as 20 seconds. The rate is estimated from the fall in glucose concentration which occurs when a suitable medium flows over the muscle at constant rate. When insulin is added to the perfusion fluid, the rate of glucose uptake rises to a value about 50 per cent higher than that established before the introduction of insulin. Under the conditions described the change in uptake rate requires about 10 to 12 minutes to reach completion, being three-quarters complete in about 7 minutes. Although the major part of this delay must be ascribed to the time required for the washing out of insulin-free medium from the apparatus, and for the diffusion of insulin into the interstitial space, it is suggested that some of the delay may be due to processes occurring between the arrival of insulin at the fibre surface and the exertion of its characteristic effect on glucose uptake, although neither the time-course nor the nature of this induction phase is established.


Semipermeability of the nuclear membrane in the intact cell. The osmotic properties of nuclei in intact cells were studied by injecting solutions into the cytoplasm of amphibian oocytes. Subsequent changes in nuclear volume were recorded photographically. The injection of solutions containing polyvinylpyrrolidone or bovine serum albumin caused changes in nuclear volume which were related to the colloid osmotic pressure of the solution injected. The concentration in which no significant nuclear volume change occurred (the isotonic range) was 1.0 to 1.5 per cent polyvinylpyrrolidone (2.0 to 3.75 x 10(-4)M). 2 per cent bovine serum albumin had no significant effect on nuclear volume, whereas 4 per cent caused a significant decrease. The significance of these findings is discussed in terms of the permeability characteristics of the nuclear membrane.


Protoplasmic streaming of an internodal cell of Nitella flexilis; its correlation with electric stimulus. The sudden cessation or sudden decrease in velocity of the protoplasmic streaming of Nitella flexilis is observed whenever an action potential is elicited. The action potential can be generated by an electric stimulus after its refractory period, whether the flow is at a complete standstill or on the way to recovery. The membrane potential is generally decreased more or less when the rate of flow is decreased on application of salts or other agents. There is, however, no parallelism between these two. The membrane potential decreases proportionally with applied voltage of subthreshold intensity, while the rate of flow does not change appreciably. Only on application of a superthreshold voltage does the flow stop suddenly. In one case the rate of flow decreased to half without appreciable decrease in membrane potential. In another case it continued flowing at about one-half rate, although the membrane potential was almost zero. The Q(10) of the rate of flow is about 2, while it is 1.1 to 1.5 for the membrane potential. The sudden cessation of the protoplasmic streaming is supposed to be caused by the temporary formation of certain interlinkages among contractile protein networks in the endoplasm during excitation at the cathodal half of Nitella.


Enzyme biosynthesis in Escherichia coli. Escherichia coli B synthesized beta-galactosidase and an enzyme system for D-xylose when exposed to lactose and xylose respectively in nitrogen-free media. The amount of beta-galactosidase formed in the absence of external nitrogen depended upon the nature of the medium in which the cells had originally been grown. Half as much of this enzyme was synthesized without exogenous nitrogen by cells taken from a nitrogen-rich medium as was formed by cells under favorable conditions with an external supply of nitrogen. Escherichia coli B contained a pool of nitrogen compounds soluble in 80 per cent ethanol and made up of several ninhydrin-positive components. One of these was identified chromatographically as glycine using an authentic radioactive sample. Another substance behaved like serine on the chromatograms. The internal pool of amino acids and peptides was large enough to account for the beta-galactosidase synthesized by cells exposed to lactose in a medium free of nitrogen. Some degree of interaction of the syntheses of the beta-galactosidase and xylose enzyme systems was observed in nitrogen-free media. This interaction produced a greater effect on the formation of beta-galactosidase and was attributed to a limiting factor(s) in the internal nitrogenous pool or to a limiting intermediate in enzyme synthesis.


Pathways of terminal respiration in marine invertebrates. II. The cytochrome system of Aplysia. The classic spectrophotometric method for identification and characterization of respiratory enzymes has been used for the study of the cytochrome system of Aplysia. Particles have been prepared from the buccal mass and the gizzard muscles. Difference spectra taken on isolated particle suspensions show the presence of a complete cytochrome system composed of five components: cytochrome a, b, c, c(1), and a(3). As indicated by the peaks of the sharp absorption bands of their reduced forms, they are very similar to the cytochromes of mammals and yeast. Cytochrome a(3) has been identified as the terminal oxidase of Aplysia muscle by means of the spectrophotometric study of its carbon monoxide compound. Further evidence for the presence of a cytochrome system in Aplysia was obtained by assays of the catalytic activities of the isolated particles: succinic dehydrogenase, cytochrome oxidase, DPNH cytochrome c reductase. The cytochrome oxidase activity was strongly inhibited by carbon monoxide in the dark; the inhibition was totally relieved by light. Cytochrome c has been extracted and purified from muscle tissue. Its spectrum is almost identical with that of the mammalian pigment both in the oxidized and reduced forms. From the hepatopancreas a new respiratory enzyme has been extracted which has many physical and chemical properties in common with cytochrome h from terrestrial snails.