The value of electroretinography: in the diagnosis of pigmentary degenerations of the retina.


The tonographic effects of echothiophate (phospholine) iodide: reversal by pyridine-2-aldoxine methiodide (P2AM).


Modification of facility of outflow; by perfusion of the vitreous chamber in the enucleated cat eye.


Fluorescing illumination in cataract surgery.


A new approach to surgery of the inferior oblique muscle.


Corneal and auditory findings in Boeck's Sarcoid.


The use of the visuscope; for mapping a field of retinal function.


Phaco-genic glaucoma.

Phaco-genic glaucoma.


The effects of color on the human organism.


Occlusion of the cilioretinal artery.

Occlusion of the cilioretinal artery.


The Gesell Developmental Schedules and the physically handicapped child.


A new prosthetic multiple action shoulder unit.


Technique for cataract section and suture without a trained assistant.


An improved tape for eye bandaging.

An improved tape for eye bandaging.


Finger exerciser.

Finger exerciser.


Fluorescent test objects; for pantoscopic tangent screen.


Functioning of a rehabilitation unit for tuberculosis patients.


New suturing forceps for cornea and cataract work.


Gelatin film used as a seton in glaucoma.


Flexible retractor.

Flexible retractor.


Monocular trial frame.

Monocular trial frame.


Hyphema and raised intraocular pressure.


FREDERICK CARL CORDES.

FREDERICK CARL CORDES.


Cyclotron cataracts.

Cyclotron cataracts.


External ophthalmoplegia; as part of congenital myasthenia in siblings: myasthenia gravis in children: report of a family showing congenital myasthenia.


New irrigating device especially useful for anterior chamber irrigation.


The syndrome of the aortic arch: ocular manifestations of pulseless disease and a report of a surgically treated case.


Observations on recurrent erosion of the cornea.


Cytomegalic inclusion disease: report of a case.


Modified knife and techniques for discission.


A review of data on the occurrence of glaucoma.


Goniotomy technique in congenital glaucoma.


Drainage of sub-retinal fluid in retinal detachment surgery.


Mimosine cataract.

Mimosine cataract.


The treatment of iris melanoma.

The treatment of iris melanoma.


Penetrating autokeratoplasty of entire cornea.


Researches into the regional distribution of eye disease.


The yellow pigment of human lenses.

The yellow pigment of human lenses.


The clinical estimation of the ocular rigidity.


Signs and symptoms of uveitis. I. Anterior uveitis.


Signs and symptoms of uveitis. II. Classification of the posterior manifestations of uveitis.


The pathogenesis of the glaucoma field: clinical evidence that circulatory insufficiency in the optic nerve is the primary cause of visual field loss in glaucoma.


Nematode endophthalmitis: Toxocara canis: report of one case.


Histologic aspect of corneal changes; due to hereditary, metabolic, and cutaneous affections.


Prepubertal intraocular malignant melanoma.


Unilateral exophthalmos from intracranial lesions.


The influence of some inhibitors of carbonic anhydrase; on the potassium and sodium content of the aqueous humor.


Repository drugs in the treatment of trachoma.


Correction of up-drawn or tear drop pupil.


Histochemical studies on the normal and swollen cornea.


Further studies on the relationship between amblyopia and the Stiles-Crawford effect.


Some clinical observations for optometrists working with low vision patients.


The Telecon lens for the partially sighted.


The color rator: a new instrument for the assessment of color aptitude in industry.


Avenues of referral should be kept open.


A.O.A. president's annual address before the Academy--state of the profession.


Observations on the fitting of corneal contact lenses.


School screening in R-1 Jefferson County, Colorado; a brief statistical report.


How good is the H-R-R test for color blindness.


Lines of constant hue in the blue corner of the color mixture diagram.


Vision and learning.

Vision and learning.


Brightness contrast, illumination intensity and visual efficiency.


The use of high-add bifocals in cases of low visual acuity.


Refracting patients with an over active ciliary; a case report.


Optometry and interprofessional relations.


A review of optometry in Colombia.

A review of optometry in Colombia.


The cardiac conduction tissue and its blood supply in the dog.


Hyperadrenocorticism (Cushing's disease); a study of surgically resected adrenal glands.


Sensitization by potassium deficiency for the production of myocardial necrosis by stress.


Myocardial ischemia and early infarction: an electron microscopic study.


Chemotherapeutic management of mycosis fungoides; a survey of 214 cases.


The role of unsaturated fats in lowering serum cholesterol levels.


The pathogenesis of artificial cranial deformation.


Drugs used in the control of dental pain.


Racial differences in heat tolerance.

Racial differences in heat tolerance.


The release of acid phosphatase and beta-glucuronidase from cytoplasmic granules in the early course of autolysis.


Widely distributed necrotizing arteritis induced in rabbits by experimental renal alterations. I. Comparison with the vascular lesions induced by injections of foreign serum.


Frequency of blood group antigens in the descendants of Guayquerí Indians.


The cranial base.

The cranial base.


Cell death. II. The effect of injury on the enzymatic protein of Ehrlich tumor cells.


Acid mucopolysaccharide granules in the glomerular epithelium in gargoylism.


Changes in the proportions of the female foot during growth.


Cortisol and citrate metabolism.

Cortisol and citrate metabolism.


Contrasting effects of stress and cortisol overdosage in the rat.


Histochemical studies of acidophilic, crystalline intranuclear inclusions in the liver and kidney of dogs.


Effect of testosterone on testicular lesions produced by DL-ethionine in rats.


Regression of traumatic cutaneous and aural lipid deposits in cholesterol fed rabbits.


Gamma irradiation on rat whole blood cholinesterase.


Experimental modifications and changes with age in pineal succinic dehydrogenase activity.


The effects of treatment on the sternal marrow.


Endogenous dilution of administered labeled acetate during lipogenesis and cholesterogenesis in two types of obese mice.


Incorporation of C14-amino acids into protein of isolated diaphragms: an effect of insulin independent of glucose entry.


Changes in body composition attendant on force feeding.


Effects of epinephrine on lactic and keto-acid production, phosphate balance and pH changes in the isolated perfused frog liver.


Distribution of amylase in the gastrointestinal tract of the rat.


Effect of glucose and inosine triphosphate on seasonal variation of gastric acid production in Rana pipiens.


Gastric distensibility and age in the mouse.


Augmentation of mouse thyroid iodide pump activity after withdrawal of propylthiouracil.


Response of the normal and thyroidectomized cat to severe cold.


Modification of radiation injury in rats through gastrointestinal tract shielding and bone marrow therapy.


5-Hydroxytryptophan decarboxylase activity in rat mast cells.


Effect of pH on norepinephrine-induced contractions of isolated arterial smooth muscle.


Effect of reserpine on excitability of the turtle heart.


Strength-duration curves in the hypothermic dog heart.


Relative importance of venous and arterial resistances in controlling venous return and cardiac output.


Effects of intravenous administration of a fat emulsion on blood coagulation in dogs.


Effects of phosphoethanolamine and phosphoserine on blood coagulation mechanism.


Use of levarterenol in treatment of irreversible hemorrhagic shock.


Cardiovascular effects of levarterenol, hydrocortisone hemisuccinate and aldosterone in the dog.


Oxygen transport in hemorrhagic shock as a function of the hematocrit ratio.


Effect of time and volume of blood overtransfused on the loss of plasma and protein in the dog.


Morphological and physiological changes in the skin as a result of long exposure to cold.


Effects of norepinephrine and 5-hydroxytryptamine on the pulmonary circulation of the spinal dog.


Drug-induced changes in blood pressure and in blood sodium as measured by glass electrode.


Relation of sympathetic nervous system to blood pressure of bone marrow.


Effect of adrenalectomy and cortisone on peripheral nerve function.


Effects of altitude and of anesthesia on brain electrolytes and lactic acid.


Latencies of the electroretinogram and optic tectum evoked potentials in the chicken.


Effect of procaine on electrical properties of squid axon membrane.


Effect of acetazoleamide alone and during asphyxia on hippocampal and cortical activity in the marsupial phalanger.


Responses at cerebral somatosensory I and peripheral nerve evoked by graded electrocutaneous stimulation.


Stress-relaxation in mammalian gastrocnemius muscle.


Distribution of acid-soluble nucleotides in hind leg muscles of mice with dystrophia muscularis.


Factors modifying water metabolism in rats fed dry diets.


Comparison of external loss of sodium with loss from sucrose space in adrenalectomized rats.


Effects of menadione on active sodium transport in isolated frog skin.


Effect of nephrectomy on the minute renal circulation.


Autoregulation of flow in isolated rat kidney in the absence of red cells.


Local effect of serotonin on renal vascular resistance and urine flow rate.


Tissue pressure and critical closing pressure in the dog kidney.


Effect of endotoxin on renal function in the dog.


Urinary excretion by nonionic diffusion.


Renal tubular transport of diodrast-I 131 and PAH in Necturus: evidence for simultaneous reabsorption and secretion.


Renal concentrating operation in hypothermic dogs.


Development of an isolated perfused mammalian kidney.


Abdominal compression reaction: causes and characteristics.


Pneumatosis cystoides intestinorum hominis; with a case report.


Peptic ulcer; a chemical imbalance.

Peptic ulcer; a chemical imbalance.


The anal papilla.

The anal papilla.


Prophylactic proctology.

Prophylactic proctology.


Psychiatric study of a mass murderer.

Psychiatric study of a mass murderer.


Post-encephalitic behavior disorder; a forgotten entity: a report of 100 cases.


A criminologist looks at privilege.

A criminologist looks at privilege.


The problem of privilege: historical and juridical sidelights.


Growth of psychiatrists during and after residency training: an objective evaluation.


Current theoretical concepts in psychosomatic medicine.


Developmental and sexual factors in women: a comparison between control, neurotic and psychotic groups.


The nature of space flight.

The nature of space flight.


On the dynamics of the manic-depressive personality.


Experimental studies of stress in space flight.


Selection techniques for space crews.

Selection techniques for space crews.


Symposium on space psychiatry: discussion.


A rapid urine color test for triflupromazine (vesprin).


Clinical experiences with a new phenothiazine.


Preliminary report on imipramine (tofranil).


Psychiatric response of geriatric-psychiatric patients to mellaril (TP-21 Sandoz).


Catatonic-like states following phenothiazine therapy.


The usefulness and effectiveness of equanil in children.


Experiences with P-M, G-M succinycholine modified electroconvulsive therapy.


Acute toxic hypertension due to triflupromazine: report of a case.


Death due to massive overdose of meprobamate.


Prolonged hypotension due to chlorpromazine.


PSYCHOTHERAPY and the prevention of accidents.


An attempt to formulate a system of psychotherapy in 1818.


The unconscious present in analytic therapy.


Ego strengthening aspects of supportive psychotherapy.


The etiology of sociopathic reactions.

The etiology of sociopathic reactions.


Brief psychotherapy in a mental hygiene clinic.


Psychotherapy with latent schizophrenics.


What do readers read in popular writings on psychologic matters? Some responses to an article on psychoanalysis.


The significance of the socio-economic status of the patients of Freud and of Adler.


Irrational psychotherapy: an appeal to unreason. IV.


Emil A. Gutheil, 60 years old.

Emil A. Gutheil, 60 years old.


A note on The Threepenny Opera.

A note on The Threepenny Opera.


Experimental studies on the relationship between anxiety, dreams and dream-like states.


A bookshelf on the social sciences and public health.


Training of public health personnel in the United States and Canada; a summary of 10 years' advance in schools of public health 1947-1948 to 1957-1958.


A new simple test paper for mass detection of phenylketonuria.


The press, the physician, and the public health officer.


Survey and evaluation of sanitation services.


The influence of socioeconomic factors on the distribution of hepatitis in Syracuse N.Y.


Preservation of foods by irradiation.

Preservation of foods by irradiation.


Preservation of foods by irradiation; viewpoint of industry.


An epidemiological study of congenital malformations in New York State.


Motivations toward health examinations.

Motivations toward health examinations.


Erythema infectiosum; report of an area-wide outbreak.


A selected public health bibliography with annotations.


Some factors in the closer coordination of health and welfare services.


The role of community health services in meeting the needs of mothers and children.


What about Soviet medicine and public health.


Public health as viewed by the medical student.


The local health officer in occupational health.


Agricultural industry: the changing pattern.


An evaluation of young adults with severe neuromuscular disorders to determine community needs for vocational rehabilitation services.


A study of patterns of patient referral to a medical clinical in a rural state: methodology.


Multiple antigen for immunization against poliomyelitis, diphtheria, pertussis, and tetanus. II. Response of infants and young children to primary immunization and eighteen-month booster.


Epidemiologic observations of an outbreak of Asian-strain influenza in a closed population.


A project for studying the geographic distraction of cancer within a single county as related to environmental factors.


Coronary arteriography.

Coronary arteriography.


A comparison of techniques for visualization of the coronary arteries.


Calcification of the coronary arteries.

Calcification of the coronary arteries.


Cinecardiometry and cine-electrokymography; new angiographic techniques for the analysis of cardiac mechanics.


The roentgenologic features of Ebstein's anomaly of the tricuspid valve.


Foreign bodies in the heart; a review of the literature since 1952 and a case report.


Normal pulsations in the pulmonary vascular tree as seen with roentgenoscopic image amplification.


Great vessel involvement in lung cancer: angiocardiographic report on 250 consecutive proved cases.


Roentgen findings in aneurysm of the descending thoracic aorta.


Roentgen signs of contrast material dissection of aortic wall in direct aortography.


New technique of contrast visualization of the distal aorta, pelvic and lower extremity arterial system in obliterative vascular disease.


Functional ascending phlebography of the lower extremity by serial long film technique; evaluation of anatomic and functional detail in 62 extremities.


Demonstration of liver regeneration by splenoportal venography.


The effect of ionizing radiations on capillary sprouting and vascular remodelling in the regenerating repair blastema observed in the rabbit ear chamber.


The angiographic study of carotid insufficiency and cerebral ischemia.


A method for localizing the pineal gland on anteroposterior projections.


A new method for localizing the calcified pineal gland on the lateral skull roentgenogram.


The roentgenologic aspects of tympanoplasty; an otologist's viewpoint.


Osteoblastic metastases to the floor of the skull simulating meningioma en plaque.


Restoration of the sella turcica after treatment of pituitary adenomas.


Pantopaque ventriculography in the localization of surgical lesions of the posterior fossa.


Cisternal pneumoencephalography.

Cisternal pneumoencephalography.


Dynamic encephalography.

Dynamic encephalography.


Roentgenologic principles of a new stereotaxic apparatus.


The normal cervical diskogram; with clinical observations.


Block of the spinal cord caused by herniated disk.


Extensive lumbar meningocele associated with neurofibromatosis.


X-irradiation exencephaly.

X-irradiation exencephaly.


Fractures of the shaft of the tibia; a clinical and experimental study.


Comparison of ureteral and renal injuries.


Complications of closed chest trauma.

Complications of closed chest trauma.


Is "simple" rib fracture a simple injury.


Diagnostic and prognostic factors in abdominal trauma.


Gas gangrene; clinical inferences from experimental data.


The present status of dextran as a plasma expander.


Pasteurized human plasma.

Pasteurized human plasma.


Follow-up medical survey of the Texas City disaster.


First-aid equipment for traffic accidents.


Albert G. Walter: nineteenth century Pittsburgh pioneer in the surgery of trauma.


A new plastic prosthesis for repairing tissue defects of the chest and abdominal wall.


Early management of the fractured hip.

Early management of the fractured hip.


Management of intertrochanteric fractures of the femur.


Pelvic support osteotomy for certain fracture complications of the hip.


Subtotal anterior lumbar disc excision and vertebral body fusion. III. Application to complicated and recurrent multilevel degenerations.


Emergency room experience in a community hospital.


The mechanisms involved in skiing injuries.


Impartial medical testimony.

Impartial medical testimony.


The impartial medical testimony project.


The impartial panel of medical examiners.


An appraisal of chemotherapy as an adjuvant to surgery for cancer.


On the utilization of medicomilitary history.


Vulvectomy; a review of fifty-five cases.


Muscle adenylic acid as an adjunct to prepare patients with phlebitis and ulcers for definitive surgery.


Bilateral mixed tumors of the parotid gland.


The value of liver function tests.

The value of liver function tests.


Observations on the surgical treatment of peptic ulcer; a six year review of 101 male patients.


Postoperative complications in the elderly surgical patient.


Pancreatic cystogastrostomy.

Pancreatic cystogastrostomy.


Cranial reconstruction with ethylenediamine-treated bone.


Segmental dilatation of the colon; a new entity.


Open chest versus closed chest cardiac resuscitation.


Studies on the phrenic nerves and the diaphragm of the dog.


The anterolateral approach to the upper cervical vertebrae.


Microscopic variables in a standardized laparotomy wound in the rat.


Lymphadenectomy via the transperitoneal (anterior abdominal) approach for cancer of the testis.


Congenital esophageal stenosis; pathologic studies following resection.


Conservative management of eventration in the newborn, with survival.


Voluntary bilateral posterior dislocation of the shoulder joint.


Rupture of the thoracoacromial artery in anterior dislocation of the shoulder.


Argentaffine tumour of the jejunum with perforation.


Intestinal obstruction; a complication of anticoagulant therapy.


Pancreatic apoplexy; report of a case treated by partial pancreatectomy, with recovery.


Spontaneous perforations of combined benign ulcers, gastric and duodenal.


Volvulus of the right colon complicating subhepatic cecum.


Case analysis clinic.

Case analysis clinic.


Our surgical heritage.

Our surgical heritage.


Proctoscopy: importance and technic.

Proctoscopy: importance and technic.


Anaphylactic emergencies and their management.


Pain in the chest.

Pain in the chest.


Retrograde pelvic arteriography.

Retrograde pelvic arteriography.


Arrhythmias in acute myocardial infarction: a brief review.


Comparative incidence of side reactions of methylprednisolone and prednisolone in allergic patients: a study of 363 patients.


Abdominal Hodgkin's sarcoma: case report.


Use of intravenous priscoline in the treatment of subdeltoid bursitis.


Fatal typhoid fever in an illegal immigrant: case report.


Clinical study of a new antispasmodic.

Clinical study of a new antispasmodic.


Perphenazine in urology and surgery.

Perphenazine in urology and surgery.


Crusade in America: the pursuit of equanimity.


The acute psychiatric patient in the general hospital; why it is desirable and what makes it feasible.


Renal papillary necrosis: case report.

Renal papillary necrosis: case report.


Clinical studies on the hypoglycemic syndrome: a correlation between clinical and laboratory findings.


Methindethyrium, an un-symmetrical bis-quaternary ammonium salt; its use in a fixed mixture of hypotensive agents.


Triamcinolone in the treatment of dermatoses.


Topical management of acne: a new antiseptic.


Recent concepts of pruritus and eczema.

Recent concepts of pruritus and eczema.


Dyclone; a topical urethral anesthetic.

Dyclone; a topical urethral anesthetic.


Pentobarbital sodium; a neglected gastro-intestinal antispasmodic; statistical evaluation of therapy in 463 patients by machine methods.


Blurred vision: some common causes.

Blurred vision: some common causes.


Rock 'n roll: a modern aspect of St. Vitus Dance; implications for the theory of mental contagion.


Solitary pulmonary nodules found in a community-wide chest roentgenographic survey; a five-year follow-up study.


The pathology of 1957 (Asian) influenza.


The helium-dilution method in determination of ventilatory disturbances; a new method for data treatment.


Respiratory function tests; normal values at median altitudes and the prediction of normal results.


Pulmonary function changes in bilateral resection for pulmonary tuberculosis.


A practical routine for the presurgical evaluation of lung function in pulmonary tuberculosis.


Alveolar cell carcinoma; a review with a report of four cases.


Microscopic enumeration of mycobacteria in pulmonary lesions of tuberculous mice; effect of prior BCG vaccination.


Chemotherapy of tuberculosis. IV. Stability of hydrazones of isoniazid in biologic fluids.


Pneumoliths in profusion in silicosis.

Pneumoliths in profusion in silicosis.


Serum protein electrophoretic pattern and Middlebrook-Dubos titer in tuberculous children following BCG vaccination.


The effect of isoniazid upon the growth of tubercle bacilli from pulmonary lesions.


Bronchograms under hypnosis.

Bronchograms under hypnosis.


Quantitative aspects of neutral red reactions of typical and atypical mycobacteria.


Measurements of the activity of ambulatory hospitalized tuberculous patients and the effects of a tranquilizing agent.


The best doctor in the hospital.

The best doctor in the hospital.


Tuberculosis case finding in psychiatric hospitals; a discussion of the resurvey interval.


The use of enzymes to aid filtration of oropharyngeal washes through membrane filter.


Histoplasmin sensitivity in Alaskan natives.


Surgery of subpleural blebs; indications and contraindications.


The distinction between regenerative and atypical alterations in the bronchial mucosa.


Segmental atelectasis in children with primary tuberculosis.


Pleural fluid amylase in pancreatitis and other diseases.


Relapse rate in a two-to eleven-year follow-up study of patients with pulmonary tuberculosis treated with and without anti-microbials and discharged from 1946 through 1955.


Serologic relationship of old tuberculin-sensitized sheep erythrocytes and trypsinized human erythrocytes.


Antigenicity of antimycobacterial serums.


Agenesis in the pulmonary arterial circulation; report of two cases.


Pulmonary histiocytosis X with diabetes insipidus.


The tuberculous alcoholic before and during hospitalization.


Distinguishing mycobacteria by the niacin test; a modified procedure.


The effect of topical hydrocortisone acetate ointment at the site of intracutaneous tuberculin reaction.


Catalase and peroxidase activities of isoniazid-susceptible and -resistant strains of M. tuberculosis; relationship between the results of a test for enzymes and those of the indirect drug-susceptibility test.


Urine test for the detection of PAS in ambulatory tuberculous patients.


Effects of kanamycin, streptovaricin, paromomycin, novobiocin, and ristocetin on murine leprosy.


Elimination of precleaning cage-laid hens' eggs in preparation of egg fluid for tuberculosis bacteriologic media.


Changes in tuberculosis as seen by a pathologist.


Urban reservoirs of tuberculosis.

Urban reservoirs of tuberculosis.


How can elimination of tuberculosis as a public health problem be achieved.


Joseph David Aronson, 1889-1958.

Joseph David Aronson, 1889-1958.


The correlation of the reaction to protein from certain mycobacteria (paratubercle bacilli) with the reaction to tuberculin (OT).


Studies on the virulence of tubercle bacilli using P32-labeled bacilli. I. The comparison of elimination in vivo of P32 derived from heat-killed virulent and avirulent tubercle bacilli.


Tuberculosis in medical students at the University of Maryland.


The incidence of segmental lesions in primary tuberculosis in childhood with special reference to the effect of chemotherapy.


Lung structure in three dimensions after inflation and fume fixation.


The evolution and early results of tracheal fenestration.


Pulmonary resection for drug-resistant cavitary tuberculosis utilizing ancillary drugs.


Enlargement of the innominate and subclavian arteries simulating mediastinal neoplasm.


Toxic psychosis due to isoniazid; report of three cases with studies of patterns of isoniazid inactivation in the serum.


Evolution of murine leprosy.

Evolution of murine leprosy.


Differentiation of human tubercle bacilli from atypical acid-fast bacilli.


The effects of mechanical agitation on the growth of the H37Ra strain of M. tuberculosis.


A new method of counting the viable organisms in BCG vaccine.


Chemotherapy in pneumoconiosis complicated by tuberculosis.


[Problems in surgery with extracorporeal circulation with special considerations of anesthesia].


Placentation of the terrestrial treeshrew (Tupaia tana).


An experimental study of the locus of origin of the chick parathyroid.


Subcommissural organ secretion in the dehydrated rat.


Histological, histochemical and electron microscopic observations on synovial membrane.


The identification and electron microscopy of myoepithelial cells in the Harderian gland.


Study of the time-course production of acid mucopolysaccharides by fibroblasts in a synthetic medium.


Vascular patterns in the red and white muscles of the rabbit.


A technic for photographic intraocular transplants in living mice.


Morphogenetic studies of the rabbit. XX. A comparison of the weights of the brain and of its parts in a large and in a small sized race of rabbits.


The distribution of the coronary arteries of the rabbit.


Topographical and clinico-otological observations on the cerebrospinal fluid cisterns in the base of the brain.


Studies on the lungs in the pig.

Studies on the lungs in the pig.


The lobulation of the mammalian lung.

The lobulation of the mammalian lung.


The respiratory tissue of Dugong (Halicore Dugong).


The arrangement of the ansa spiralis of the goat colon.


Fluothane (halothane) in closed circuit anaesthesia.


Comparison of vasopressor responses in the presence of phenothiazine derivatives.


The classification and performance of respiratory valves.


Compliance in apneic anesthetized adults.


Changes in lung thorax compliance during orthopedic surgery.


Nitrous oxide hypalgesia in trained subjects.


Studies on renal vasoconstrictor responses.


Relationship of bowel and liver to drug protection against shock.


Carbon dioxide and oxygen blood levels with a carbon dioxide controlled artificial respirator.


Modification of the circulatory response to electroshock therapy by thiopental.


Effects of alternating positive and negative endotracheal pressures on the caliber of bronchi.


The electroencephalogram in hypothermia with circulatory arrest.


Cyclohexamine (Cl-400): a new intravenous agent.


Electroencephalography in anesthesiology.


Pneumoencephalography and air embolism: simulated anesthetic death.


Problems in anesthesia for paraplegics.

Problems in anesthesia for paraplegics.


Anesthesiologists, surgeons and malpractice suits.


Phenazocine, a new benzomorphan narcotic analgesic.


Nomogram for chloroform.

Nomogram for chloroform.


Operating table screen.

Operating table screen.


Blade for lateral intubation.

Blade for lateral intubation.


Adaptors for ECG electrodes.

Adaptors for ECG electrodes.


Lighted stylet.

Lighted stylet.


[Ischemic thrombosis of the inferior vena cava].


New valve for nonrebreathing systems.

New valve for nonrebreathing systems.


[New classification of purpuras].

[New classification of purpuras].


The action of a lytic enzyme from spores of a bacillus on various species of bacteria.


[Isolation and counting of Enterobacteriaceae by means of hemoculture on filtering membranes].


[Demonstration & identification of the colicinogenic property of various E. coli phagetypes pathogenic for infants; epidemiological significance of this study].


[Safety in handling bodies impregnated with radio-isotopes].


Investigations on mumps virus; propagation of mumps virus in chick embryos during serial allantoic passages with undiluted inocula.


[Treatment of cancer of the base of the tongue].


Brain Tumors in Filipino children.

Brain Tumors in Filipino children.


Zinc metabolism in hepatic dysfunction.

Zinc metabolism in hepatic dysfunction.


The physiologic basis for vasopressor therapy during shock.


Chemotherapy of malignant tumors.

Chemotherapy of malignant tumors.


Tobacco hypoglycemia.

Tobacco hypoglycemia.


The relationship between heart disease and gall-bladder disease.


Heredity in ankylosing spondylitis.

Heredity in ankylosing spondylitis.


Virtue of prompt anticoagulant therapy in impending myocardial infarction: experiences with 318 patients during a 10-year period.


Dermatomyositis and malignancy: a review of the literature.


Polycythemia vera. I. Clinical and laboratory manifestations.


Polycythemia vera. II. Course and therapy.


Immunization after intra dermal and subcutaneous injection of Asian influenza vaccine.


Dermatologic allergy. V. Critique and review of the recent literature.


Tetracycline provocation in lupus erythematosus.


Quinidine purpura: report of six cases.

Quinidine purpura: report of six cases.


The rational approach in the use of bronchodilators in chronic respiratory disease.


The electroencephalogram in allergic children.


Reactions to influenza vaccine.

Reactions to influenza vaccine.


Distribution and immunochemical properties of human tissue and tumor antigens II.


The effect of drugs in acetylcholine-induced bronchial obstruction.


Development of multiple sensitivities from primary sensitivity to nickel.


Prochlorperazine as an aid in the treatment of bronchial asthma.


Problems of contact dermatitis in the atopic individual, with reference to neomycin and ragweed oil sensitivity.


Departments of medicine in 1970. I. Staff policies.


Hydatid cyst of the liver rupturing into the bile ducts: a case report describing a characteristic triad of symptoms.


Case of a diabetic with a Kimmelstiel-Wilson syndrome and a normal glucose tolerance.


Primary hemangio-endothelioma of the heart.


Myxedema coma.

Myxedema coma.


Cushing's syndrome and the Guillain-Barré syndrome.


Roentgenologic and clinical aspects of multiple myeloma with report of an unusual case.


Cystic fibrosis of the pancreas in young adults.


Cervical spondylosis: pilot therapeutic trial.


Abbreviated electrodiagnostic tests of denervation; a comparative study.


Useful polythene splints.

Useful polythene splints.


Pain in the foot and heel.

Pain in the foot and heel.


Resorption of intracutaneously injected Congo red.


Role of hypersensitivity in the pathogenesis of rheumatoid arthritis.


Ankylosing spondylitis in women.

Ankylosing spondylitis in women.


Significance of the Waaler-Rose test, streptococcal agagglutination, and antistreptolysin titre in the prognosis of rheumatoid arthritis.


Indications for surgical intervention in rheumatoid arthritis of the wrist and hand.


Effect of intramuscular injection of pituitary tissue in rheumatoid arthritis.


Reiter's disease in the female.

Reiter's disease in the female.


Rheumatic iritis and iridocyclitis.

Rheumatic iritis and iridocyclitis.


DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association.


The surgery of anastomotic ulceration.

The surgery of anastomotic ulceration.


Malignant epithelial tumours in the Sudanese.


Hyperplasia and metaplasia in the bronchial epithelium.


A curator's curiosity.

A curator's curiosity.


Operations upon the common bile duct for stones.


Intestinal obstruction in the neonatal period due to agenesis of the myenteric plexus.


The effect on survival of certain variables in breast cancer.


Fistula cancer.

Fistula cancer.


Ileocecal prolapse.

Ileocecal prolapse.


Rehabilitation of the ulcerative colitis patient with special reference to one stage proctocolectomy and matured ileostomy.


Newer concepts of nutrition by the intravenous route.


A clinical approach to parotid gland tumors.


Total thyroidectomy for cancer of the thyroid: significance of intraglandular dissemination.


Hyperthyroidism and pregnancy.

Hyperthyroidism and pregnancy.


Studies of ulceration and edema of the lower extremity by lymphatic cannulation.


Treatment of venous ulcers of the leg; review of 110 operative cases.


Objective evaluation of vagectomy-antrectomy for duodenal ulcer.


Cancer of the tongue.

Cancer of the tongue.


A method of reconstructing the lower lip following excision for carcinoma.


A quantitative survey of onchocerciasis in persons under twenty years of age in an endemic area of Northern Nigeria; with a consideration of the epidemiology based on a mathematical hypothesis, by F. N. Macnamara.


Primary malignant tumors of the lung other than bronchogenic carcinoma.


Some approaches to the development of chemotherapeutic compounds.


Injuries to main-stem bronchi: complete separation of left with successful anastomosis and instability of right due to fracture of multiple cartilages.


The identification of Cysticercus bovis, with special reference to degenerate cysticerci.


Studies on the relationship of tick-bite to tick pyaemia of lambs.


Observations on the ovipositioncycle of Aëdes (Stegomyia) aegypti (Linnaeus), II.


The possible role of lowdensity microfilaraemia in the spread of Wuchereria bancrofti by Culex fatigans in East Africa.


A further note on the action on fish of chlorinated hydrocarbons when used as larvicides.


Pheochromocytoma; interesting experiences with three cases.


Early activity in sporozoite-induced Plasmodium falciparum infections.


Polymorphism in Trypanosoma gambiense and Trypanosoma rhodesiense, and the significance of the intermediate forms.


Anal feeding as a method of infecting tsetseflies with Trypanosoma gambiense. I. The technique.


A guide to the identification of the West African species of the Fusca group of tsetse-flies, by dissection of the genitalia.


The relative virulence of Trypanosoma brucei to young and to adult white rats.


Serum proteins in East African kala-azar.


Onchocerciasis in the Sudan Republic.

Onchocerciasis in the Sudan Republic.


Observations on Plasmodium berghei infection in white rats: blood changes and acquired resistance.


Studies on filariasis in Malaya: on the migration and rate of growth of Wuchereria malayi in experimentally infected cats.


A note on the duration of Toxoplasma infection in the guinea-pig.


Serological study of effusions in tuberculous pleural cavity.


Antibodies in serous cavities, especially in pleural space, produced by experimental tubercular infection.


Quantitative determination of sugar components of polysaccharide fractions of human tubercle bacillus by paper chromatographical technique.


Antigenic activity of tubercular polysaccharide in hemagglutination and in precipitation.


Clinical observations on hemagglutination and precipitation with polysaccharide fractions obtained from human tubercle bacillus.


Observations on the use of flumethiazide in the treatment of edema.


Clinical evaluation of parabromdylamine maleate (dimetane) in the treatment of allergic and pruritic dermatoses.


The treatment of amebic dysentery with paromomycin; a preliminary report.


Puromycin alone or in combination with phthalyl-sulfathiazole in the treatment of intestinal amebiasis.


Triacetyloleandomycin: a study of blood levels and clinical effects.


Local use of triamcinolone acetonide in dermatology.


Typhoid carriers treated with high dosages of penicillin.


Evaluation of treatment of acute gonorrhea in the male with varying dosage schedules of penicillin V potassium.


Systemic moniliasis: a clinicopathological report of five cases.


Combined irradiation-heat processing of canned foods. III. Cooked ground beef inoculated with spores of a putrefactive anaerobe.


The amylase of Clostridium acetobutylicum. II. Adsorption.


Microbiology of meat curing. II. Characteristics of a Lactobacillus occurring in ham curing brines which synthesizes a polysaccharide from sucrose.


Hereditary changes of some physiological properties in Streptomyces rimosus.


Toxicity of dyes and related compounds to wood-destroying fungi.


Chlorination inhibitors affecting the biosynthesis of tetracycline.


Maple sirup. XII. Effect of zinc on the growth of microorganisms in maple sap.


Areal contrasts in the abundance of hydrocarbon oxidizing microbes in soils.


Construction and use of a continuous recording nephelometer.


Search for substances which reduce the heat resistance of bacterial spores.


Efficient utilization of fatty oils as energy source in penicillin fermentation.


Analytical microbiology. V. Metabolic response methods.


Comparative studies on measles and distemper viruses in suckling mice.


Correlation between canine distemper and measles virus neutralizing capacities in human sera.


Tick-borne meningoencephalomyelitis in Sweden.


Active immunization against poliomyelitis with live attenuated viruses.


Plaque formation by herpes virus in chick embryo tissue.


Studies on the virus of hepatitis contagiosa canis (HCC). II. Susceptibility of guinea pigs to experimental infection with HCC virus.


Studies on the infection of tumor cells by extraneous viruses. II. Susceptibility of two transplantable mouse tumors to neurotropic viruses.


The behaviour of some influenza viruses in tissue cultures of kidney cells of various species.


Experimental studies on equine infectious anemia (swamp fever). I. Re-transmission of Arakawa's virus to horse.


Survey of knowledge and problems in field of arthropod-borne virus infections.


Identification of a cytopathogenic agent called U-virus recovered from patients with non-diphtheritic croup and from day-nursery children.


Interference between influenza and poliomyelitis viruses in tissue culture.


Haemadsorption in vaccinia-infected tube tissue cultures.


Infection of domestic poultry with the viruses of foot-and-mouth disease and vesicular stomatitis.


A comparative study of the prototypic Hill strain of ECHO virus, type 9, and several Coxsackie-like viruses related to it antigenically.


The time-scale of mitosis in the Euglenineae.


The sterilizing effect of ethylene oxide vapor on different microorganisms.


The influence of iron, sulphite and paraformaldehyde on the formation of 2,3-butanediol in the cultures of Bacillus polymyxa.


A study of the changes in the physiological properties of Dhar yeast by growing it in cultures containing sucrose, ethyl alcohol or methyl alcohol as source of carbon food.


Fritz Mietzsch. Preceding.

Fritz Mietzsch. Preceding.


[Extraction of drugs].

[Extraction of drugs].


Jesse Philip Greenstein, 1902-1959.

Jesse Philip Greenstein, 1902-1959.


Ethanolamine on choline deficiency in rats.


Reversible inhibition of enzymes by interaction with synthetic polysaccharide macroanions.


Purification and properties of a C-1 diphosphatase from Spinacia oleracea.


The role of phospholipides in the metabolism of amino acids by the mold Penicillium chrysogenum.


Cytochrome c concentration in the tissues of normal and tumor-bearing rats.


Comparative lymphatic absorption of beta-sitosterol and cholesterol by the rat.


Tissue sulfhydryl groups.

Tissue sulfhydryl groups.


Cation exchange chromatography of human pituitary thyrotropic activity.


Conalbumin: a rapid, high-yield preparation from egg white.


The occurrence of nicotinic acid mononucleotide in yeast.


The behavior of various antivitamin B6 in Saccharomyces carlsbergenis.


Further studies on the metachromatic reaction of metaphosphate.


Activation of amino acids and amides by cell-free preparations.


Zeacarotenes, new provitamins A from corn.


Carotenoids and related colorless polyenes of aged Burley tobacco.


Choline and aldehyde oxidation by rat liver.


The turbidimetric determination of deoxyribonuclease activity.


Inhibition of plasmin, trypsin and the streptokinase-activated fibrinolytic system by 6-aminocaproic acid.


Induced changes in the efficiency of energy transfer in Porphyridum cruentum. I.


Oligosaccharides in the seeds of Sesamum indicum L.


Transfer of fructose and glucose across surviving guinea pig intestine.


Saponins of the peanut: isolation of some peanut sapogenins and their comparison with the soya sapogenols by glass-paper chromatography.


The separation of some steroids by glass-paper chromatography.


The separation of some bile acids by glass-paper chromatography.


Determination of 3-beta-OH sterols in serum and tissues by the anthrone reaction.


Some immunochemical differences between associated and dissociated hemocyanin.


The UV-action spectrum of the lysine decarboxylase induction in Bacterium cadaveris.


Concerning the site of protein synthesis in leaves.


Social and biological factors in infant mortality. VIII. Mortality in the post-neonatal period.


Nephrocalcinosis infantum.

Nephrocalcinosis infantum.


A case of calcification of the basal ganglia with osteoporosis and other abnormalities.


Sulphobromophthalein excretion in premature infants.


Systolic murmurs in children; a survey of 240 cases.


Sequestration of the lung.

Sequestration of the lung.


Investigation into the aetiology and treatment of pica.


The pre-eruptive illness of measles.

The pre-eruptive illness of measles.


An English family with Waardenburg's syndrome.


Renal tubular damage in infantile gastro-enteritis.


Spontaneous hyperinsulinism due to benign hyperplasia of islet cells.


Idiopathic infantile hypoglycaemia.

Idiopathic infantile hypoglycaemia.


Extended exchange transfusion in pre-hydropic infants.


Massive adrenal haemorrhage in the newborn.


[Dubin-Johnson type chronic idiopathic icterus].


[Celiac disease caused by disorders of gluten digestion].


[Infantile gastroenteritis due to pathogenic colibacilli observed at Clermont-Ferrand; development of the antibiogram & therapeutic results].


[Visceral polyposis & mucocutaneous melanic pigmentation (Peutz syndrome)].


[Hydrocholecystitis with malformation of the cystic & choledochous ducts in an 8-year-old girl].


Drug administration by means of cigarettes.


The use of polyvinylpyrrolidone in the assay of coronary active drugs.


Increased sensibility of the hypothalamic cells to the uncoupling effect of tranquillizing drugs.


Pharmacology of some monohalogenated derivatives of sulfolane (tetrahydrothiophene-1,1-dioxide).


Gastrointestinal pharmacology of antipyretic-analgetic agents. II. Absorption and smooth muscle effects.


Action of synchronizing and desynchronizing drugs on strychnine-induced cortical spikes.


Tachyphylaxis. III. Studies on the rabbit ear and dog leg.


Gastrointestinal pharmacology of antipyretic-analgetic agents. I. Effects on acid secretion and ulcer formation in the Shay rat.


Nicotine-like actions of ephedrine on isolated guinea pig auricles.


Influence of reserpine on the behavior of mice susceptible to audiogenic seizures.


Effect of thialbarbitone (kemithal) upon the serum potassium levels of normal and adrenalectomized rats.


Influence of musular exercise upon the metabolism of radioactive ethyl alcohol in mice.


Hypothermia by internal cooling.

Hypothermia by internal cooling.


Influence of muscular work on the blood alcohol concentration in men.


Physio-pharmacological effects on suprarenal secretion of adrenaline and noradrenaline in dogs.


Urinary output of adrenaline and noradrenaline after medullo-adrenalectomy in dogs.


Contributions to silkworm biochemistry. V. Time of biosynthesis of fibroin and its location in the silk of Bombyx mori L. (European race).


Contributions to silkworm biochemistry. VI. Time of biosynthesis of fibroinogen and its location in the reservoir of the silkgland, at the end of the fifth age.


The relation of acid-base equilibrium of blood to the onset of ventricular fibrillation in the hypothermic heart.


Contributions to silkworm biochemistry. VII. Ordered progression on fibroinogen in the reservoir of the silkgland during the 5th instar.


The influence of immersion hypothermia and rewarming on oxygen consumption and glycogen content of the rat heart.


Some properties of the mammalian ventricular muscle.


Egg white reaction in rats and 5-hydroxytryptamine.


Radioactive iodine, thyroid and renal hypertension in the dog.


Recordings of clotted hemolymph of insects by electron microscopy.


[Edematous inflammation of Bauhin's valve; pathological & clinico-radiological correlation].


[Icterus due to incomplete stenosis of the lower choledochus in the course of juxtapapillary ulcer; biliodigestive anastomosis & gastrectomy for exclusion].


Juvenile rheumatoid arthritis in New York City; 161 cases.


Deafness prevention in children: loss of hearing for the middle tones.


Scrofula: then and now: 1500 years of tuberculous lymphadenitis in accessible nodes.


Norethandrolone and reserpine: a study of treatment of nervous, underweight children.


CLINICAL conference: St. Luke's Hospital, New York.


An analysis of the rehabilitation needs and prognoses of 232 cases of cerebral vascular accident.


Temperature rise of various tissues in the dog on exposure to ultrasound at different frequencies.


Iontophoresis studies with a radioactive tracer.


Role of personality traits in rehabilitation problems.


Oral intermittent positive pressure breathing (OIPPB) in poliomyelitis.


Recognizing anxiety in counseling.

Recognizing anxiety in counseling.


[Experimental arthroplasty and prednisone].


[Thecoma of the ovary: clinical, anatomical & pathological data].


[Middlebrook-Dubos hemagglutination reaction in pregnancy].


[Functional retractive syndromes in fibrothorax; clinico-radiological reconstructions and physiopathological synthesis].


A comparative quantitative study of the central depressant effect of seven clinically used phenothiazine derivatives.


Comparative tests for rapid evaluation of hypocholesteremic compounds.


Cell wall lysis and the release of peptides in Bacillus species.


Use of microorganisms for studies of growth and morphogenesis.


Viruses and tumors; an old problem in the light of recent advances.


[Whole blood, plasma & fractions: a review].


What a crossmatch must do to protect the recipient.


The fatty acid composition and glyceride structure of Indian wild-boar fat.


Plant enzyme reactions leading to the formation of heterocyclic compounds. 3. Plant amine oxidase and the formation of pyrrolidine and piperidine alkaloids.


Calcium and magnesium metabolism in calves. 4. Bone composition in magnesium deficiency and the control of plasma magnesium.


Lecithinase and lysolecithinase of intestinal mucosa.


Properties and specificity of pancreatic phospholipase A.


Studies on gastric proteolysis. 4. Proteinase activity of gastric juice and gastric-mucosal extracts at pH 6 to 8.


Rates of oxidation of galactose and glucose in erythrocytes and liver after lactose feeding.


The effect of insulin antibodies on glucose uptake by the isolated rat diaphragm.


Studies in detoxication. 78. Glucuronide and ethereal sulphate formation in hens.


Nitrogenous compounds and nitrogen metabolism in the Liliaceae. 6. Changes in nitrogenous composition during the growth of Convallaria and Polygonatum.


Nitrogenous constituents of the thoracic muscle of the African migratory locust (Locusta migratoria migratorioides).


gamma-Amino-eta-butyric, aspartic, glutamic and pyrrolidonecarboxylic acid; their determination and occurrence in grass during conservation.


Studies on biosynthesis of cholesterol. 8. The effect of Mg2+ and Mn2+ ions and of adenosine triphosphate on enzymic activity of microsomes in sterol biosynthesis from mevalonic acid.


The metabolism of [16-14C] oestrone in vitro.


The biochemistry of rumen protozoa. 1. Carbohydrate fermentation by Dasytricha and Isotricha.


The biochemistry of rumen protozoa. 2. Some carbohydrases in cell-free extracts of Dasytricha and Isotricha.


The formation of mercapturic acids. 1. Formation of mercapturic acid and the levels of glutathione in tissues.


The formation of mercapturic acids. 2. The possible role of glutathionase.


Hormonal factors affecting glucose 6-phosphatase activity. 1. Effect of hypophysectomy and replacement therapy in the rat.


Hormonal factors affecting glucose 6-phosphatase activity. 2. Some effects of diet and of alloxan diabetes in the rat.


Metabolism of 11-oxygenated steroids. 1. Influence of the A/B ring junction on the reduction of 11-oxo groups.


Metabolism of 11-oxygenated steroids. 2. 2-Methyl steroids.


Studies on the biosynthesis of riboflavin. 5. General factors controlling flavinogenesis in the yeast Candida flareri.


Partial purification and some properties of a cellulase from Helix pomatia.


The transport of carotenoids, vitamin A and cholesterol across the intestines of rats and chickens.


The interaction of some factors affecting the kinetics of a molluscan beta-glucuronidase.


Purification of the nicotinic acid hydroxylase system of Pseudomonas fluorescens KB1.


Studies on the adenosine triphosphate-phosphate exchange and the hydrolysis of adenosine triphosphate catalysed by a particulate fraction from the mosquito.


The effect of monoiodoacetate on the aerobic metabolism of ox retina in vitro.


The biosynthesis of porphyrins from porphobilinogen by Rhodopseudomonas spheroides.


The fatty acids of human milk from mothers on diets taken ad libitum.


Amino acid incorporation into cell-free preparations of normal and neoplastic lymphatic tissues of the rat.


A bacterial dextranase.

A bacterial dextranase.


Transglucosidase activity of rumen strains of Streptococcus bovis. 2. Isolation and properties of dextransucrase.


The initiation of deoxyribonucleic acid synthesis in the connective-tissue cell, with some observations on the function of the nucleolus.


A substance from animal tissues which induces ketonuria.


The reactivation of phosphorylated chymotrypsin.


Substrate specificity of rumen cellulolytic enzymes.


Sterol metabolism. 4. The absorption of 7-dehydrocholesterol in the rat.


Sterol metabolism. 5. The uptake of sterols by organelles of intestinal mucosa and the site of their esterification during absorption.


Biochemical aspects of bovine ketosis.

Biochemical aspects of bovine ketosis.


Unsaponifiable constituents of liver; ubiquinone and substance SC in various species.


A study of unsaponifiable extracts obtained from hydrolysates of pancreas and spleen.


Unsaponifiable fraction of lipid from normal and diseased human kidney.


Human haptoglobins: estimation and purification.


The genetic control of transferrins in humans.


Distribution of sodium and potassium within cattle lens.


Studies on sulphatases. 24. The use of barium chloranilate in the determination of enzymically liberated sulphate.


Location 14C in protein from isolated rat diaphragm incubated in vitro with [14C] amino acids and with 14C02.


The reactions of amino acids with soluble ribonucleic acid from guinea-pig mammary cells.


Turnover of nucleic acids in a non-multiplying animal cell.


A lipophosphoprotein complex in hen plasma associated with yolk production.


Studies on the conversion of glucose into lactic acid in the Ehrlich ascites tumour.


The distribution of bound acetylcholine and choline acetylase in rat and pigeon brain.


Studies on alkaline phosphatases. I. Kinetics of plasma phosphatase of normal and rachitic chicks.


Studies on alkaline phosphatases. 2. Factors influencing pH optima and Michaelis constant.


The component fatty acids of Penicillium spinulosum fat.


The ultrastructure of cell membranes and their derivatives.


Pyruvate metabolism in Lactobacillus brevis.


Principles and potentialities of cytochemical staining methods for the study of intracellular enzyme distributions.


Distribution in interaction of enzymes within animal cells.


Structure and function in microorganisms.


Changes in cellular components in liver injury.


Polynucleotide phosphorylase from human sperm and urine. II. Activities on nucleotides and nucleic acids.


The enzymic destruction of histamine in vitro.


Ornithine as a precursor for the pyrrolidine ring of nicotine.


Pteridines as substrates of mammalian xanthine oxidase. II. Pathways and rates of oxidation.


Enzymic transfer of sulfur from beta-mercaptopyruvate to cyanide.


2-Ketogluconoreductase in micro-organisms.


Hydroxamates of tissue-activated acyls: preparation and separation.


The incorporation of [14C] uracil and [14C] orotic acid into RNA in the cytoplasm of Amoeba proteus.


The catabolism of glucose in soluble adult and fetal-heart preparations.


Studies on the enzymic hydrolysis of monophosphoinositide by phospholipase preparations from P. notatum and ox pancreas.


Formation of a lytic enzyme by a strain of Bacillus subtilis.


Properties of a lytic enzyme produced by a strain of Bacillus subtilis.


Isolation and characteristics of the enzyme acyl 5'-nucleotidase.


Serine as an intermediate in the assimilation of methanol by a Pseudomonas.


Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol.


Interactions of basic polyelectrolytes with the red blood cell. II. Agglutination of red blood cells by polymeric bases.


A method for the study of the elastic properties of protein monolayers.


Studies on tobacco leaf ribonuclease. III. Its role in the synthesis of tobacco mosaic virus nucleic acid.


Studies on the electron transport system. XX. Chemical and physical properties of the coenzyme Q family of compounds.


Studies on the terminal electron transport system. XXI. On the properties of a soluble lipoprotein dissociated from the succinic dehydrogenase complex.


Studies on the terminal electron transport system. XXII. The lipide composition of coenzyme Q lipoprotein.


The isolation and the estimation of the sugar of pyrimidine nucleosides and nucleotides after reduction.


Photoxidation processes in normal green Chlorella cells. II. Effects on metabolism.


Conversion of myo-inositol to D-glucuronic acid and L-gulonic acid in the rat.


The adenosine triphosphatase activity of perch sperm flagella.


The induction by Mn++ of heritable respiratory deficiency in non-dividing populations of Saccharomyces.


Mechanism of plastein formation.

Mechanism of plastein formation.


Specificity of pyruvate kinase.

Specificity of pyruvate kinase.


The enzymic cleavage of N-acetylneuraminic acid.


Proteolytic enzyme of Actinidia chinensis.


Preparation of nucleoprotein and deoxyribonucleic acid from small quantities of lymphoid tissue disintegrated by ultrasound.


High-molecular-weight ribonucleic acid from rat liver.


An assay of pepsin using ribonuclease as substrate.


Some optical properties of fetuin and glucagon.


Metabolic reduction of 16 alpha-hydroxy-oestrone and 16-oxooestradio-17 beta by liver tissue in vitro.


A simplified procedure for the preparation of alpha and beta melanocyte-stimulating hormones.


Some observations of the complex formed between pepsin and human mercaptalbumin.


Mechanism of the carboxyl activation of glycine in extracts of Photobacterium fischeri.


Stoichiometry in the estimation of disulphide in intact proteins using mercuric chloride.


The latent rhodanese of isolated rat-liver mitochondria.


Mannitol formation by Piricularia oryzae.


Synthesis by Escherichia coli of a beta-galactosidase-like protein under the influence of thiouracil.


Similarity in mode of action of chloramphenicol and erythromycin.


The isolation of uridine pyrophosphorhamnose from two noncapsulated variants of pneumococcus type II.


The enzymic activation of D-alanine in Lactobacillus arabinosus 17-5.


The exceptional resistance of certain oligoribonucleotides to alkaline degradation.


The optical configuration of the alanine residues in a uridine nucleotide and in the cell wall of Staphylococcus aureus.


Incorporation in vitro of amino acids into ribonucleoprotein fractions of microsomes.


Fractionation of transfer ribonucleic acid.


A mechanism for the effects of dinitrophenol and temperature on the hydrolytic activity of myosin.


Incorporation of [3H] thymidine in a deoxyriboside-requiring bacterium.


The chemical nature of intracellular peptidases.


The grouping of serine phosphate residues in phosvitin and casein.


Autologous bone marrow infusion as an adjunct in therapy of malignant disease.


Some observations on blood factors RhA, RhB and RhC of the Rh-Hr blood group system.


Nutritional megaloblastic anemia associated with sickle cell states.


Immunologic mechanisms in heavily irradiated mice treated with bone marrow.


The proportion of reticulocytes in the erythrocytes of the spleen as compared with those of circulating blood, with special reference to hemolytic states.


Experimental production of grape cells and their relation to the serum gamma globulin and seromucoids.


The basophilic granulocyte.

The basophilic granulocyte.


Pseudotumor of hemophilia in a patient with PTC deficiency.


PREVENTION of kernicterus as a complication of hemolytic disease and other forms of jaundice of the newborn.


Refractory megaloblastic anemia associated with excretion of orotic acid.


Studies on Erythropoiesis. XI. Reticulocyte response of transfusion-induced polycythemic mice to anemic plasma from nephrectomized mice to and plasma from nephrectomized rats exposed to low oxygen.


Studies on erythropoiesis. XII. The effect of transfusion-induced polycythemia in the mother on the fetus.


Studies on erythropoiesis. XIV. The relationship of humoral stimulation to iron absorption.


Evaluation of plasma erythropoietic-stimulating factors in anemic uremic patients.


Studies of the production and life span of erythrocytes in myeloid metaplasia.


Inability of haptoglobin to bind myoglobin.


Hereditary spherocytosis-sicklemia in the Negro; case report and study of a Negro family having multiple instances of hereditary spherocytosis.


The macrocytosis of hepatic disease. I. Thin macrocytosis.


Life span of thrombocytes and erythrocytes in normal and thrombocytopenic calves.


Homografts of bone marrow in dogs after lethal total-body radiation.


Patterns of hemopoietic recovery in irradiated mice.


Studies on the genetics of leukocyte antigens.


Lymph node reactivity. I. Non-cancer patients.


Relation of mastocytoma to mast cell leukemia, and of heparin, histamine and serotonin to mast cells.


Effect of phospholipid fractions upon the coagulation defects in patients on long-term dicumarol therapy.


Multiple myeloma: presentation of two cases with unusual clinical manifestations.


Report of seven cases of mediastinal tumors operated at the San Patricio VA Hospital.


Thoracic-outlet syndrome.

Thoracic-outlet syndrome.


Right lower quadrant pain in the adult male, from roentgen point of view.


Symposium on tumors of bone.

Symposium on tumors of bone.


Multiple facial fractures; case report.

Multiple facial fractures; case report.


[Address of the incoming president].

[Address of the incoming president].


[Relation between catalase activity, virulence and drug resistance of some strains of Mycobacterium tuberculosis isolated from pathological human specimens].


[Cytotoxic activity of alkyl sulfonates. VII. Probable mechanism of action of 2-chloroethyl-methanesulfonate (C. B. 1506) & of 2-fluoroethyl methanesulfonate].


Neuro-pathologic observations in phenylketonuria.


Paget's disease of the skull and secondary basilar impression.


The cervical spinal canal in syringomyelia.


Refsum's syndrome; heredopathia atactica polyneuritiformis; a report of three cases, including a study of the cardiac pathology.


Bilateral retrobulbar optic neuritis.

Bilateral retrobulbar optic neuritis.


Aphasia in a congenital deaf-mute.

Aphasia in a congenital deaf-mute.


Intestinal flora and parasites: their effect on nutrition.


The treatment of myotonia: a controlled clinical trial.


Establishment of nutritional requirements in man.


Sudden bodily jerks on falling asleep.

Sudden bodily jerks on falling asleep.


Acute hemiballismus treated by ventrolateral thalamolysis.


Casts of foetal lateral ventricles.

Casts of foetal lateral ventricles.


The intraneural topography of the circumflex, musculocutaneous and obturator nerves.


The anomalous origin of the left coronary artery from the pulmonary artery.


The radiological features of syphilitic aortic incompetence.


Endomyocardial fibrosis in the Ceylonese.


Further observations on coupled extrasystoles and automatic ventricular rhythms.


Mitral restenosis.

Mitral restenosis.


Pulmonary vascular changes in a dog after aortopulmonary anastomosis for four years.


The less common forms of pulmonary hypertension.


Heart failure in patients with high blood pressure.


Spontaneous capillary pulsation in complete heart block.


Endocardial fibro-elastosis in adolescents and adults.


The heart lung coefficient in older people.


Development of valvular lesions in metastatic carcinoid disease.


Amisometradine (rolicton) in the treatment of congestive heart failure.


Studies in pulmonary hypertension in congenital heart disease.


Unexplained electrocardiograms in the African.


Hunter's polydystrophy (gargoylism) with cardiac lesions and some formes frustes.


Effect of doisynolic acid on experimental atheroma in the cockerel.


Aspects of pulmonary blood flow in atrial septal defect.


James William Brown.

James William Brown.


Effort syncope in aortic stenosis.

Effort syncope in aortic stenosis.


Electrocardiographic studies during the inhalation of 30 percent carbon dioxide in man.


The induction of anaesthesia: a safe technique for the novice.


General anaesthesia for operative obstetrics: with special reference to the use of thiopentone and suxamethonium.


Acute hypertension developing under anaesthesia: a near fatality.


Further trials of lignocaine in spinal anaesthesia.


The appli of a regime for the treatment of neostigmine resistant curatization.


Health and happiness and the family.

Health and happiness and the family.


Stress and the gut.

Stress and the gut.


The stabilizing role of the general practitioner.


Emotional stress and infertility.

Emotional stress and infertility.


The patient as a person.

The patient as a person.


Stress and asthma.

Stress and asthma.


Anxiety and muscle-tension pain.

Anxiety and muscle-tension pain.


The place of stimulant drugs in the therapy of stress disorder.


The Sokko doctor.

The Sokko doctor.


Therapeutics.

Therapeutics.


Haematuria.

Haematuria.


The pH of the skin surface of infants aged one to seven days.


The behaviour of radioactive mercury and zinc after application to normal and abnormal skin.


Pyoderma gangrenosum with clumping of blood cells and abnormal plasma protein.


Haemangiosarcoma; a case report.

Haemangiosarcoma; a case report.


The effect on haemostasis of changes in the proportions of plasma and cells in the blood.


The enzymic formation of haem by the incorporation of iron into protoporphyrin; importance of ascorbic acid, ergothioneine and glutathione.


Rh genotype of the father and severity of haemolytic disease of the newborn.


Studies of temperature and pH stability of human antihaemophilic factor (AHF) in plasma and in a concentrate.


Pathogenesis of haemophilia; a critical analysis of the evidence for the Bridge anticoagulant.


Plasma antihaemophilic factor (AHF) concentrations in families of patients with haemorrhagic states.


The behaviour of coagulation factors during anticoagulant therapy with special reference to the one-stage test as an index of therapy.


The role of Hageman factor in the initiation of blood coagulation.


The phospholipid distribution in the erythrocyte in paroxysmal nocturnal haemoglobinuria.


Behaviour of the free erythrocyte protoporphyrins and of the erythrocyte copper in iron deficiency anaemias.


Medical examinations for public safety.

Medical examinations for public safety.


Measuring dust exposure with the thermal precipitator in collieries and foundries.


Health problems of epoxy resins and amine-curing agents.


Pulmonary fibrosis in an aluminium worker.


Two cases of hydrazine hydrate dermatitis without systemic intoxication.


The value of mobilization of lead by ethylenediamine-tetra-acetate in the diagnosis of lead poisoning.


The chemotherapy of poisoning by organophosphate anticholinesterases.


A follow-up study of men exposed to cadmium oxide fume.


The mechanical properties of the lung in pneumoconiosis of coal-miners.


Further studies of the neutralization of silica toxicity in vitro.


The employment of diabetics.

The employment of diabetics.


Ocular manifestations of internal carotid artery occlusion.


Some results in retinal detachment surgery.


Some effects of decreased plasma sodium concentration on the composition and tension of the aqueous humour.


Abnormal retinal correspondence; a preliminary report on the treatment of abnormal retinal correspondence by Cüppers' after-image method.


Drug administration in cataract surgery.


Rhinosporidiosis of the conjunctiva.

Rhinosporidiosis of the conjunctiva.


Arterial anomaly at the optic disc.

Arterial anomaly at the optic disc.


Microphakia.

Microphakia.


JAMES ANDREW GUNN.

JAMES ANDREW GUNN.


2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning. The soluble methanesulphonate of the oxime 2-hydroxyiminomethyl-N-methylpyridinium (P2S) has been used to treat animals poisoned with sarin or ethyl pyrophosphate. The effect of the size of the dose, and its time of administration in relation to poisoning, have been examined. This oxime is very efficient in conjunction with atropine when given either before or after poisoning. About 30 mg./kg. seems to be the optimum therapeutic dose of the methanesulphonate. The significance of this optimum is discussed in relation to the treatment of accidental poisoning by organophosphate insecticides in man.


Plasma adrenaline and noradrenaline after phenoxybenzamine administration, and during haemorrhagic hypotension, in normal and adrenalectomized dogs. The intravenous administration of the antiadrenaline drug phenoxybenzamine (Dibenzyline) markedly raised the arterial adrenaline and noradrenaline concentration in dogs lightly anaesthetized with thiopentone. Graded haemorrhage led to a further rise in the amounts of amine. In adrenalectomized dogs, phenoxybenzamine moderately increased the plasma noradrenaline concentration. During haemorrhagic hypotension, previous treatment of adrenalectomized animals with phenoxybenzamine led to a significantly greater rise in plasma noradrenaline compared with that of adrenalectomized animals subjected to haemorrhage without treatment with phenoxybenzamine. Thus, phenoxybenzamine (1) raised plasma amine concentration largely due to adrenal medullary stimulation, and (2) led to increased plasma noradrenaline concentrations during sympathetic stimulation in adrenalectomized animals. The previous administration of phenoxybenzamine reduced the amount of blood which could be withdrawn before final circulatory collapse in both normal and adrenalectomized dogs.


A method for measuring the activity of compounds with an activity like vitamin K against indirect anticoagulants in rats. A method for the estimation of the activity of compounds like vitamin K using rats treated with an indirect anticoagulant is described. The assay measured the speed of onset and magnitude of the antidotal effect. Under the conditions employed, only vitamin K(1) produced a significant response. Vitamin K(3) and its water-soluble derivatives were inactive. Both the magnitude and the speed of onset of the antidotal effect of vitamin K(1) were found to depend on the extent to which it was in solution. The assay gave results of fair accuracy and reproducibility, which permitted a full statistical analysis and provided an estimate of error.


The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin. Carbonic acid inhibited the stimulating action of histamine on guinea-pig intestine and of oxytocin on the uterus of many animal species. This effect was relatively specific. Under the same conditions the actions of acetylcholine, KCl, adrenaline (on rabbit uterus), and ergot alkaloids were not inhibited. The electrical excitability of smooth muscle was similarly not affected. The inhibitory action of carbonic acid is directly proportional to its concentration in the medium in which the isolated organ is maintained. The study of the activity of histamine and oxytocin at different pH in a medium free of NaHCO(3) and buffered with a mixture of sodium maleate and maleic acid suggested that the inhibitory action exerted by carbonic acid was specific and independent of the simultaneous modifications of the hydrogen ion concentration. The mechanism of these phenomena is discussed.


Distribution of [14C] bemegride in tissues after intravenous injection. The distribution and excretion of bemegride labelled at the alpha carbon atoms with (14)C were studied in mice, rats, and guinea-pigs. These studies were supplemented by others made by colorimetric and absorptiometric methods on unlabelled bemegride in the body fluids of rabbits and dogs. Bemegride passed rapidly from plasma to all tissues, including brain, muscle, and fat. In addition it passed readily into the cerebrospinal fluid and the aqueous humour and to the foetus. It persisted in the tissues for longer than 24 hr., to some extent preferentially in the central nervous system. Approximately two-thirds of the dose was excreted in the bile, faeces, and urine within 24 hr. The glutarimide ring of bemegride was not completely degraded biologically.


Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion. In the rat, the ratio of the analgesic to the respiratory depressant potency was the same for morphine, codeine, diamorphine, methadone, dipipanone, piperidylisomethadone, phenadoxone, dextromoramide, and propoxyphene. The relative respiratory depressant activity of pethidine tended to be less, but the difference was not significant. The ratio of the analgesic dose to the dose preventing transport of a charcoal meal in the rat was about the same for morphine, codeine, pethidine, methadone, phenadoxone, dimethylthiambutene, and propoxyphene; the relative activities of these compounds in inhibiting the peristaltic reflex of the isolated guinea-pig ileum were also similar. However, because of differences in the slopes of regression lines in the charcoal meal test, some compounds (for example, morphine) had a greater effect on gastrointestinal propulsion than others (for example, pethidine) when given at moderate analgesic dose levels.In studies of the effects of intracisternal morphine in the rat, effects on the spinal reflex of the tail were to some extent dissociated from effects on the threshold for a squeak response. Further, the delaying of transport of a charcoal meal paralleled depression of respiratory rate, and this is evidence for the participation of a central as well as a peripheral action in the effect of morphine on the gastrointestinal tract. The delay in propulsion was reduced by nalorphine and increased by atropine and two general anaesthetic substances, but was unaffected by a number of other pharmacological agents.


Some effects of reserpine and hydraliazine upon tissue respiration and the concentration of adenosine nucleotides in certain tissues. The effects of reserpine and hydrallazine upon the oxygen uptake of preparations of rat brain, liver, and kidney and rabbit aorta have been investigated using the Warburg "Direct" method. In these tissues reserpine did not significantly stimulate respiration at any of the doses used. Concentrations of 10 or 50 mug./ml. had no significant effect upon respiration, but higher doses (330 mug./ml.) depressed it in all the tissues studied. This effect was also seen in rat brain at a reserpine concentration of 100 mug./ml. which had no significant effect in other tissues. Hydrallazine (50 or 100 mug./ml.) depressed respiration in all tissues studied. Stimulation at lower doses was not seen.After sublethal doses of reserpine, depletion of energy rich phosphate compounds occurred in brain and liver but not in skeletal muscle and heart. Hydrallazine also depleted brain of energy rich phosphate compounds, but did not affect liver, heart, or skeletal muscle. The bearing of these results on the mode of action of reserpine and hydrallazine is discussed.


The effect of reserpine on the acetylcholine content of different areas of the central nervous system of the dog. The acetylcholine content of the frontal and temporal lobes, hippocampus, hypothalamus, cerebellum and spinal cord was estimated in 18 dogs 3 hr. after the intravenous administration of reserpine. Another group of 7 dogs served as control. After reserpine (0.5 mg./kg. body weight) there was an increase of acetylcholine in all the areas under study except in the hippocampus. The increase was specially marked in the hypothalamus. In the hippocampus, however, reserpine caused a significant decrease of acetylcholine.


Some quantitative uses of drug antagonists. Various applications of pA(x) measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pA(x) measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pA(h), is introduced to express the activity of unsurmountable antagonists.


Some pharmacological properties of the alpha-toxin of staphylococcus pyogenes. The alpha-toxin of Staphylococcus pyogenes produced a slowly developing contracture of isolated preparations of rabbit jejunum and of guinea-pig ileum which persisted after thorough washing and left the gut unresponsive to further doses of alpha-toxin or of acetylcholine. After incubation with antitoxin, the alpha-toxin no longer produced a contracture. Antitoxin only prevented the alpha-toxin response if added to the bath fluid before but not after the alpha-toxin. Certain drugs reduced the alpha-toxin contracture when added to the bath fluid before or after the alpha-toxin, but the contracture reappeared on washing. Papaverine abolished the contracture and pethidine was only slightly less active. Mepyramine, amyl nitrite, caffeine, aminophylline, adrenaline and ephedrine partly reduced the contracture. Hexamethonium, cocaine, tubocurarine and gallamine had no effect. The effect of atropine was only small. The gut-stimulant activity/haemolytic unit of two alpha-toxin samples differed greatly; this difference did not appear to be due to activity of impurities. The implications of these observations are discussed.


Studies of a proteolytic enzyme from Schistosoma mansoni. The presence of a proteolytic enzyme has been demonstrated in ground-up preparations of Schistosoma mansoni. A twenty-fold purification has been achieved by ultracentrifugation at pH 3.0; the enzyme has an optimum pH of 3.9 and a marked substrate specificity for haemoglobin. No significant proteolysis was observed either with whole serum at pH values of 3.9, 6.0 or 8.0, or with isolated serum proteins at pH ranges between 2.5 and 7.7. The evidence is discussed that this enzyme may be located in the intestine of the schistosomes and that it is, at least in part, responsible for the supply of amino acids to the organisms.


Renal effects of veratridine.

Renal effects of veratridine. Veratridine hydrochloride injected subcutaneously into unanaesthetized rats inhibited water diuresis. A linear relationship between log dose and antidiuretic effect could be established over the dose range 50 to 200 mug./100 g. of body weight. When veratridine hydrochloride was injected intravenously in doses from 10 to 30 mug./100 g., this relationship was also linear. In terms of its antidiuretic action, the alkaloid was approximately five times as effective when given intravenously. Rats anaesthetized with urethane responded to an intravenous injection with a more pronounced inhibition than unanaesthetized animals. Protoveratrine injected intravenously into unanaesthetized rats showed no clear relationship between dose and magnitude of antidiuretic effect. Veratridine hydrochloride injected intravenously had a pronounced hypotensive effect in both anaesthetized and unanaesthetized rats. Treatment with atropine did not affect this hypotensive action significantly. Atropine given subcutaneously 30 min. before an intravenous injection of veratridine hydrochloride abolished or diminished the inhibitory effect of veratridine on water diuresis. Veratridine hydrochloride injected intravenously into unanaesthetized rats caused a marked depression of the clearance of inulin and p-aminohippurate. In unanaesthetized rats with an osmotic diuresis, veratridine hydrochloride produced its usual antidiuretic effect. The urine of rats injected with veratridine hydrochloride produced an antidiuretic effect when injected intravenously into other animals. The antidiuretic potency of such urines was not affected by treatment with thioglycollate. Animals injected with veratridine excreted small amounts of a veratridine-like substance in the urine. These results do not suggest that veratridine in antidiuretic and hypotensive doses stimulated the neurohypophysis in the rat.


Effect of various electrolytes upon cardiac and skeletal musculature. In rats kept on a low-potassium diet that contains only maintenance levels of magnesium, cardiac necroses and muscular cramps were readily induced by the oral administration of sodium perchlorate or disodium hydrogen phosphate. The precipitation of these cardiac and skeletal muscle changes by sodium chlorate was prevented by the prophylactic administration of either potassium or magnesium chlorides. The protective effect of these chlorides against the cardiotoxic and convulsive effects of disodium hydrogen phosphate has already been demonstrated by our earlier experiments. Sodium sulphate produced cardiac necroses in rats maintained on the same diet, and both potassium and magnesium chlorides had a prophylactic action. Unlike sodium perchlorate, however, sodium sulphate produced no muscular cramps under these conditions. Equimolecular amounts of sodium given in the form of sodium chloride (instead of sodium perchlorate, sodium sulphate, or disodium hydrogen phosphate) did not cause cardiac necroses or muscular cramps in rats maintained on the potassium-deficient diet. As the same three sodium salts, namely the perchlorate, the sulphate, and the hydrogen phosphate, produced cardiac necroses in rats sensitized by either a potassium-deficient diet or by certain corticoids, it seems that the anion must play a decisive rôle, since equivalent amounts of NaCl are ineffective.


The relative activities of some tryptamine analogues on the isolated rat stomach strip preparation. The relative potencies of analogues of tryptamine and 5-hydroxytryptamine have been determined on the rat fundus preparation. This tissue had an amine oxidase activity, which, in the homogenate, was able to inactivate both tryptamine and 5-hydroxytryptamine to about the same degree. Amine oxidase inhibitors potentiated the action of tryptamine and many analogues on the isolated rat fundus preparation, but not the action of 5-hydroxytryptamine or of other hydroxytryptamines. This suggested that, in the isolated organ, the amine oxidase was unable to inactivate 5-hydroxytryptamine, but could inactivate tryptamine, 5-methoxytryptamine and many others. These results may be explained if it is supposed that tryptamine entered the cell, but because of the polar hydroxyl group 5-hydroxytryptamine did not. This hypothesis is supported by the oil/water partition coefficients. The structure/activity of the various tryptamine derivatives is discussed in the light of this assumption.


Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations. Some 3-(2-dialkylaminoethyl)-, 3-(2-alkylaminoethyl)-, and 3-(2-dialkylaminoethyl)-2-methylindoles have been synthesized and tested, along with 5-benzyloxygramine, 5-benzyloxy-3-(2-dimethylaminoethyl)-, 3-(2-aminopropyl)- and 3-(2-aminobutyl)-indoles, on the rat uterus and rat fundus strip. 5-Benzyloxy-3-(2-dimethylaminoethyl)indole, even though it contains an ethylene side-chain, was a less potent antagonist of 5-hydroxytryptamine than was 5-benzyloxygramine. The remaining compounds were still less active. There are differences between the ability of some of them to antagonize 5-hydroxytryptamine and to antagonize tryptamine. 3-(2-Dimethylaminoethyl)-2-methylindole, in particular, shows a considerable degree of specific antagonism of 5-hydroxytryptamine on both tissues.Nearly all the compounds stimulate the preparations, some combining antagonism of 5-hydroxytryptamine at low concentrations with stimulant activity at higher concentrations. The most active compound is 3-(2-dipropylaminoethyl)indole. On the rat fundus strip this has, on a molar basis, 1/40th of the stimulant activity of 5-hydroxytryptamine, and is 20 times as active as tryptamine: on the rat uterus it is only 1/200th as active as 5-hydroxytryptamine, and equal in activity to tryptamine.


The effects of reserpine and other agents upon leptazol convulsions in mice. Reserpine and tetrabenazine reduced the survival time of mice infused with leptazol. This effect was antagonized by pretreatment with iproniazid. The survival time of iproniazid-treated mice was prolonged by 5-hydroxytryptophan but not by 3:4-dihydroxyphenylalanine. These findings suggest a relation between leptazol sensitivity and brain levels of 5-hydroxytryptamine.


Mechanism of action of reserpine in producing gastric haemorrhage and erosion in the mouse. Gastric haemorrhage was produced regularly in mice within 6 hours of the subcutaneous injection of a large dose (2 to 10 mg./kg.) of reserpine or of deserpidine. Rescinnamine, syrosingopine (SU-3118), and tetrabenazine (Ro 1-9569) were less active. Gastric haemorrhage was also produced within 6 hours when 5-hydroxytryptamine (10 mg./kg.) was injected every half-hour. Neither reserpine nor 5-hydroxytryptamine produced gastric haemorrhage in mice which had been vagotomized by tying the oesophagus at the cardio-oesophageal junction or which had been pre-treated with iproniazid. Amphetamine was less effective than iproniazid in preventing gastric haemorrhage after reserpine, and the following drugs were ineffective: cocaine, methyl phenidate (Ritalin), amarin, caffeine, nikethamide, lysergic acid diethylamide and its 2-bromo derivative (BOL148). Gastric haemorrhage was not observed in mice which had been given substantial doses of atropine or of hexamethonium before reserpine. The incidence of haemorrhage was substantially reduced by treatment with an antacid mixture. It is concluded that reserpine-like drugs cause gastric haemorrhage by a mechanism which has an important central component and which involves the liberation of 5-hydroxytryptamine.


The extraction of human urinary kinin (substance Z) and its relation to the plasma kinins. Human urinary kinin (substance Z) has been extracted by modifications of the methods previously described by Gomes (1955) and Jensen (1958). The separation of two oxytocic fractions from such extracts by paper pulp chromatography (Walaszek, 1957; Jensen, 1958) could not be confirmed. Substance Z could not be distinguished from kallidin, bradykinin or glass-activated kinin by parallel quantitative assays, thus confirming that these four substances are very closely related.


Human urinary kinin excretion.

Human urinary kinin excretion. It has been shown that the isolated rat duodenum relaxes in the presence of low concentrations of plasma and urinary kinin. The tissue is at least as sensitive as the rat uterus. Vasopressin and oxytocin, in large doses, also caused relaxation of the duodenum whereas acetylcholine, substance P and 5-hydroxytryptamine caused contraction. It was concluded that if an extract is assayed on the rat uterus and the rat duodenum in parallel using plasma kinin as a standard, and the results agree, this is good evidence that the active principle being estimated is a kinin. This method is therefore both sensitive and specific for kinin estimations, but it will not distinguish between kinins of different origin. The urinary excretion of kinin in 14 healthy adults was found to be fairly constant. The minute output was unaffected by the rate of urine formation, urinary pH, or time of day. There was no increase during sweating or salivation.


The biological activity of a new analogue of oxytocin in which the tyrosyl group is replaced by phenylalanyl. A new synthetic analogue of oxytocin with a phenylalanyl group instead of a tyrosyl group has been investigated. The most prominent biological properties of this peptide were its oxytocic activity on the rat or cat uterus in vivo and on milk-ejection pressure in the rabbit. Another remarkable feature was the striking difference in pressor activity measured in spinal cats and in anaesthetized rats. The presence of the phenylalanyl group in the molecule in the above-mentioned position did not increase the antidiuretic potency in unanaesthetized rats. The authors propose a nomenclature for the peptides related to oxytocin and vasopressin.


Tracer studies of the distribution and trypanocidal action of stilbamidine in rats. [(14)C]Stilbamidine was used to study the distribution of the drug in the organs and tissues of rats following intravenous injection. The prophylactic action of stilbamidine was shown to depend upon the unchanged drug retained in tissues, especially the liver. Only the parent drug was extracted from trypanosomes when an infection was treated during the acute phase, as shown by the use of the fluorescent properties of stilbamidine in conjunction with scanning and chromatographic techniques. The action of stilbamidine on trypanosomes is therefore a direct one. A method for the synthesis of [(14)C]stilbamidine in much improved yield is also described.


Increased urinary excretion of adrenaline and noradrenaline after phenoxybenzamine. In dogs anaesthetized with pentobarbitone sodium phenoxybenzamine greatly increased the urinary excretion of adrenaline and noradrenaline. This was associated with a transient increase in the volume of urine excreted and a fall in blood pressure. Hexamethonium prevented the effects on the urinary amines and on the blood pressure. Methacholine hypotension induced an increased adrenaline excretion, but no change in noradrenaline. The excretion of adrenaline released following ganglionic stimulation by acetylcholine did not appear to be affected by phenoxybenzamine, but that of noradrenaline was increased. During infusions of adrenaline or noradrenaline, phenoxybenzamine increased the excretion of both adrenaline and noradrenaline.


THE SMOKING habits of school children.

THE SMOKING habits of school children.


Smoking habits among school children in Norway.


Air pollution and causes of death.

Air pollution and causes of death.


Sickness, change of residence, and death. II. Sickness reported in household surveys and subsequent mortality.


Forecast and follow-up an investigation into the clinical, social, and mental factors determining the results of hospital treatment.


Chronic bronchitis and emphysema: a symposium. I. The epidemiology of chronic bronchitis.


II. Clinical aspects of chronic bronchitis.


III. Pathological findings and radiological changes in chronic bronchitis and emphysema.


Certain structural aspects of lymphocytes and monocytes in relation to the clinical condition of persons exposed to ionizing radiation.


Giant cell tumour of bone.

Giant cell tumour of bone.


Cineradiographic studies of glossopharyngeal breathing.


Jejunal adenoma producing intussusception: report on a case.


Further studies of the effect of partial shielding by grids on survival of x-irradiated rats.


Electron therapy at 8 MeV.

Electron therapy at 8 MeV.


A lateral medullary syndrome following vertebral angiography.


Intravenous hydrocortisone in the treatment of a severe urographic reaction.


Inferior mesenteric artery occlusion following lumbar aortography.


A useful relation between the radiographic magnification factors in three parallel planes.


A simple determination of the dose-rates at points near any liner radium source from an isodose chart for a linear radium source having the same filtration.


A method for complete internal carotid angiography.


A wedge filter for use in treatment of carcinoma of the cervix uteri with 4 MV x-rays.


Axial surface and depth doses for elongated rectangular fields.


Facial sinuses of dental origin.

Facial sinuses of dental origin.


Some observations on gastric cysts.

Some observations on gastric cysts.


Eosinophilic granuloma of the gastro-intestinal tract: report of two cases.


Primary plasmocytoma of the stomach.

Primary plasmocytoma of the stomach.


Acute dilatation of the stomach following thoracic injury; report of two cases with discussion.


Cushing's syndrome associated with carcinoma of the bronchus.


Incarceration of a Meckel's inguinal hernia in an infant.


Unusual skeletal dystrophy associated with a soft-tissue tumour.


Teratoma of the neck in relation to the thyroid gland.


Appendix duplex.

Appendix duplex.


A case of eosinophilic colitis.

A case of eosinophilic colitis.


A case of double primary carcinomas of the oesophagus.


Small-bowel obstruction following partial gastrectomy.


Traumatic diaphragmatic hernia with strangulation and gangrene of the stomach.


Intussusception in infancy and childhood; a review of 400 cases.


Bilateral adenolymphoma of the parotid salivary gland associated with tuberculosis.


A case of metastatic carcinoma of the ileocaecal valve presenting as a primary growth.


A study of the incidence and treatment of burns in a general hospital.


Traumatic closed rupture of the upper ureter.


Grease-gun injury.

Grease-gun injury.


Retrosternal artificial oesophagus.

Retrosternal artificial oesophagus.


Varicosity of the external and pseudo-varicosity of the short (external) saphenous vein.


The technique of total cystectomy in the male.


Mucosal stenosis of the pylorus.

Mucosal stenosis of the pylorus.


Ruptured mycotic aneurysm of the superior mesenteric artery.


Prolapsed sigmoidoumbilical faecal fistula.


Relief of flushing after resection of a secreting argentaffinoma.


Myositis ossificans in the region of the hip-joint.


An abnormality of the pancreas, with diverticula of the duodenum and jejunum.


The practical urological management of the patient with spinal cord injury.


Upper urinary tract dilatation in paraplegia.


The blood supply of the renal papilla.

The blood supply of the renal papilla.


Congenital hypertrophy of the verumontanum causing bladder-neck obstruction.


Congenital posterior urethral valves: a study of thirty-five cases.


Acquired diverticulum of the male urethra.


Acquired phimosis in the elderly caused by lichen sclerosus et atrophicus.


Spontaneous rupture of the bladder.

Spontaneous rupture of the bladder.


Spontaneous rupture of the normal urinary bladder.


Abortion bladder: the late effects of introducing abortifacients into the bladder.


A consideration of the operation of partial cystectomy for fladder neoplasms.


The origin of syphilis.

The origin of syphilis.


Leishman-Donovan bodies and donovaniasis; Sir William Boog Leishman, 1865-1926; Charles Donovan, 1863-1951.


Treponemal immobilization test in expectant mothers; results in 142 reactors to standard serological tests.


Elimination of congenital syphilis.

Elimination of congenital syphilis.


Possible significance of PPLO in human genital infection.


Non-gonococcal urethritis contacts.

Non-gonococcal urethritis contacts.


PPLO of human genital origin; serological classification of strains and antibody distribution in man.


Diagnosis of trichomonad infestation by examination of stained films.


Treatment of vaginal trichomoniasis with gyno-sterosan.


V.D.R.L., Eagle, Price, and Kolmer tests; a comparison using 1,029 South African Bantu sera.


A note on the course of reagin titres in chronic biologic false positive reactors.


Comparison between the reactivity of cardiolipin antigen and a lecithin-free cardiolipin antigen (cardchol) in TPI-reactive and TPI-non-reactive sera.


Streptomycin, sodium azide, and merthiolate as bacteriostatic agents for use with the Treponema pallidum immobilization test.


VENEREAL diseases in England and Wales; extract from the Annual Report of the Chief Medical Officer for the year 1957.


Blood groups: introduction.

Blood groups: introduction.


Factors determining the relative clinical importance of different blood-group antibodies.


The inheritance of blood groups.

The inheritance of blood groups.


Some aspects of the biochemistry of the human blood-group substances.


The antiglobulin reaction.

The antiglobulin reaction.


Haemolytic disease of the new-born.

Haemolytic disease of the new-born.


The management of haemolytic disease of the new-born as a community problem.


Some associations between blood groups and disease.


Blood groups and natural selection.

Blood groups and natural selection.


Blood groups and genetic linkage.

Blood groups and genetic linkage.


Adsorption of blood-group substances from serum on to red cells.


The relation between animal and human blood groups.


Haemagglutinins in seeds.

Haemagglutinins in seeds.


Acute encephalitis in childhood.

Acute encephalitis in childhood.


The electroencephalogram in myxoedema coma: clinical and electroencephalographic study of three cases.


Value of the voice in diagnosis of myxoedema in the elderly.


Nicoumalone: a new anticoagulant.

Nicoumalone: a new anticoagulant.


Mass radiography and cancer of the lung.


Kala-azar of unusual duration, associated with agammaglobulinaemia.


Electrophoretic differential serum protein pattern in kala-azar.


Breast abscess.

Breast abscess.


Xanthocillin cream for local treatment.

Xanthocillin cream for local treatment.


The physiopathology of acute haemolytic shock.


ACROPARAESTHESIA and the carpal tunnel.

ACROPARAESTHESIA and the carpal tunnel.


SYNDROMES of islet-cell tumours of the pancreas.


HAZARDS of mass radiography.

HAZARDS of mass radiography.


CANCER risks of cosmetics.

CANCER risks of cosmetics.


Tonics.

Tonics.


Intermittent suxamethonium injections.

Intermittent suxamethonium injections.


M. J. EVANS.

M. J. EVANS.


Protein metabolism of the brain.

Protein metabolism of the brain.


Triamcinolone in the treatment of rheumatoid arthritis.


Diagnosis in the management of burns.

Diagnosis in the management of burns.


Prednisolone trimethylacetate in intra-articular therapy.


Synovial fluid changes in intra-articular therapy; effect of prednisolone trimethylacetate.


Rapid destruction of apparently compatible red cells.


Beclamide in intractable epilepsy: a controlled trial.


Renal failure in hypercalcemic sarcoidosis.


Cor triatriatum (stenosis of the common pulmonary vein); successful treatment of a case.


Myocardial infarction in a young adult.

Myocardial infarction in a young adult.


MIST. N.H.S. CO.

MIST. N.H.S. CO.


TREATMENT of haematemesis and melaena.

TREATMENT of haematemesis and melaena.


ADVICE on radiological protection.

ADVICE on radiological protection.


BREAST abscess.

BREAST abscess.


NOMENCLATURE of blood-clotting factors.

NOMENCLATURE of blood-clotting factors.


IDIOPATHIC renal acidosis in infancy.

IDIOPATHIC renal acidosis in infancy.


IN THE MARKET place.

IN THE MARKET place.


Treatment of diabetes mellitus. I. Insulin: physiological and therapeutic actions.


Transport of life in the frozen or dried state.


WILLIAM AINSLIE.

WILLIAM AINSLIE.


Conjoined twins; further observations.

Conjoined twins; further observations.


Breast cancer; a new approach to therapy.


Frozen-section diagnosis.

Frozen-section diagnosis.


The cyanotic (syncopal) attack in Fallot's tetralogy.


Case of latent nephritis treated with prednisolone.


Spontaneous haemarthrosis in osteoarthritis of knee; a report of five cases.


Immunization during pregnancy to the kidd (Jka) red-cell antigen.


Five duodenal ulcers in a sibship.

Five duodenal ulcers in a sibship.


Eight further cases of radiation-induced cancer.


Carotenaemia occurring in a case of anorexia nervosa.


REFLEX muscular spasm.

REFLEX muscular spasm.


TELLING the parents.

TELLING the parents.


Sir Arthur Conan Doyle.

Sir Arthur Conan Doyle.


A. I. SHEPHEARD-WALWYN.

A. I. SHEPHEARD-WALWYN.


Hypertension: treated and untreated; a study of 400 cases.


Some aspects of prognosis in treated hypertension.


Hospital outbreak of cross-infection due to Staphylococcus pyogenes phage type 80.


Fluoxymesterone; a new oral androgen.

Fluoxymesterone; a new oral androgen.


Effect of penicillin therapy on occurrence of second attacks in scarlet fever.


Thalassaemia in Liberia.

Thalassaemia in Liberia.


Disturbances of pigmentation with chloroquine.


Syndrome of nutritional siderosis in an Indian in Durban.