HOSPITAL statistics.

HOSPITAL statistics.


A balanced hospital community.

A balanced hospital community.


Hospital conducts course for baby sitters.


Today's practical nurse; how she is filling the nursing gap.


Today's practical nurse; concepts behind her education.


Opal 58'; surprise paper evacuation moves 13 hospitals to non-target area.


Painless renovation.

Painless renovation.


Tuberculocidal properties of four hospital disinfectants.


Quick way to measure laundry output per man-hour.


Good food; a public relations plus.

Good food; a public relations plus.


Why one hospital switched to disposable syringes and needles.


Changing concepts in the use of antibiotics in the treatment of surgical infections.


Acute pancreatitis.

Acute pancreatitis.


The use of chlorpromazine in disturbed mentally retarded children.


Phenylbutazone.

Phenylbutazone.


Essential hypertension and obesity.

Essential hypertension and obesity.


Shock of cardiac origin.

Shock of cardiac origin.


Institutional survey of pulmonary tuberculosis with special reference to smoking habits.


Hematological findings in persons working in the x-ray department.


General health and nutrition survey of the rural population in Pennathur. IV. Protein nutrition.


Study of rabies virus tropism for salivary glands.


Curative value of sulphamethoxypyridazine in experimental plague infection in mice.


General health and nutrition status survey of the rural population in Pennathur. V. Vitamin nutrition.


Interstitial nephritis in apparently normal population in Rajasthan.


Effects of acetylcholine, potassium chloride, adrenaline and pilocarpine on cooled heart.


The role of vitamin A in male infertility.


Sarcosporidiosis; case report.

Sarcosporidiosis; case report.


The suddenly ill child. I.

The suddenly ill child. I.


Sandstone + calcium in the treatment of scorpion bite.


Treatment of vertigo.

Treatment of vertigo.


Experimental study of concentration of oxygen during its absorption in small intestine.


Peptic ulcer in India.

Peptic ulcer in India.


A gamma-globulinemia.

A gamma-globulinemia.


Urinary excretion of 17-hydroxycorticosteroids in normal Indian subjects.


Bronchodilator action of five recently synthesized local anesthetics.


Phosphatase activity of B. coli.

Phosphatase activity of B. coli.


Prednisolone in pulmonary tuberculosis; case report.


The availability of cadavers in the teaching of anatomy.


Radicalism in the treatment of bone and joint tuberculosis.


The suddenly ill child. II.

The suddenly ill child. II.


A study of the early clinical signs and biochemical values of cerebro-spinal fluid in the course of tuberculous meningitis during treatment and other factors influencing the prognosis.


Radiation therapy in gynecology.

Radiation therapy in gynecology.


Bacteriology, pathology and immunopathology of tuberculosis in children.


Antitubercular chemotherapy and systemic treatment of primary tuberculosis.


Enzymes in Vibrio cholerae; a review.

Enzymes in Vibrio cholerae; a review.


Some pharmacological actions of an extract of Ocimum sanctum; preliminary observations.


Investigations on the physiology of bile secretion; effect of adrenaline and noradrenaline on bile secretion.


Electrophoretic study of protein patterns of serum from normal non-pregnant and pregnant women.


Observations on diuretic assay methods using rat and dog.


Observations on isolated heart at lowered temperature.


Psychiatric aspects of surgery.

Psychiatric aspects of surgery.


Symptomatic treatment for upper respiratory infections.


Experimental thermal burns.

Experimental thermal burns.


Occupational health services in small businesses.


Newer hazards from radiation.

Newer hazards from radiation.


PROFILES in occupational health; Clarence D. Selby.


Relapses after sulfone therapy in leprosy of the lepromatous type.


Histiocytic granulomatous mycobacterial lesions produced in the golden hamster (Cricetus auratus) inoculated with human leprosy; negative results in ten experiments using other animals.


Progress with new anti-leprosy drugs.

Progress with new anti-leprosy drugs.


The new program of leprosy control in Brazil and its results.


The effect of BCG vaccination upon the occurrence of leprosy in nursery children.


Temperature variation and leprosy deformity.


A study of the action of sulfones on the metabolism of mycobacteria.


The pharmacology of chlorothiazide and its analogues.


The origin of natural reactivity to lepromin; the association between the Mitsuda reaction and reactions to graded doses of tuberculin.


Pharmacology and potency estimation of chlorothiazide and thiazide derivatives.


The physiology of salt and water retention and the use of diuretics in treatment.


The antituberculosis and antileprosy activity of disubstituted thiocarbanilides; in particular SU 1906.


Electron microscope studies of the murine leprosy bacillus.


Pharmacology of the thiazide derivatives.


The use of chlorothiazide and hydrochlorothiazide in the treatment of congestive heart failure.


Chlorothiazide and hydrochlorothiazide in the treatment of congestive heart failure.


Results of tests with serial dilutions of lepromin in separate groups of normal young children with a comparison of two lepromins and the Dharmendra antigen.


Shakespeare's psychiatry, and after.

Shakespeare's psychiatry, and after.


The administration of diaminodiphenyl sulfone and its derivatives by the oral and parenteral routes, with an assessment of their relative values.


Friends for the road.

Friends for the road.


On the behavior of the respiratory muscles in the gasping.


Notes on leprosy in the Territory of Paua and New Guinea.


Effects of methyl- and ethyl-derivatives of NH4 on the neuromuscular junction.


Animal lepromin with leprosy bacilli from infected rats; preparation and comparative study with human lepromins.


Liver dysfunction in leprosy; results of the bromsulfalein retention test in 150 cases.


Effects of tetrodotoxin on the neuromuscular junction.


A cytological and cytochemical study of the sweat gland of the horse.


Suppressing effects on electrocortical activity of gamma-aminobutyric acid in cats.


Two new cases of epitheliomas originating in lepromas.


The experimental neurosis of albino rat caused by excessive training, (training seizure).


The third effect of polarizing electrodes and the counter current effect of electrotonus.


Effect of thyroid hormones and their metabolic products upon succinic dehydrogenase activity of mouse heart muscle in vitro.


The relation of super-precipitation to the phenomenon of dual precipitation of actomyosin.


Slow potentials induced from the illuminated part into the surrounding area of the retina.


EEG-arousal by gamma-aminobutyric acid (GABA) in the rabbit under anesthesia, cyanpoisoning or asphyxia.


The afferent innervation of the kidney and testis of toad.


The effects of temperature on actomyosin adenosinetriphosphatase activity and super-precipitation.


A single neuron activity in the secondary cortical auditory area in the cat.


Jewish Hospital; people, places and thoughts.


Jewish Hospital; internship in the early thirties.


Jewish Hospital; panorama of 1909.

Jewish Hospital; panorama of 1909.


Jewish Hospital; early clinical investigations.


Jewish Hospital; outpatient services.

Jewish Hospital; outpatient services.


Mt. Sinai Hospital; beginnings and growth.


Mt. Sinai Hospital; research in the past and present.


Northern Liberties Hospital; story of harmony.


Northern Liberties Hospital; early medical activities.


Albert Einstein Medical Center; a report of progress.


The future of the American hospital.

The future of the American hospital.


The future of American medicine.

The future of American medicine.


Management of the depressed patient; preliminary observations concerning the use of imipramine hydrochloride.


Skin cancer; a needless cause of death.

Skin cancer; a needless cause of death.


A method for study of acute myocardial infarction; brief preliminary report.


Cancer end-results evaluation; the role of the Albert Einstein Medical Center.


Experimental use of an apparatus for stapling small blood vessels.


Small intestine obstruction in the absence of x-ray findings.


Hepatosplenography with oxides of heavy metals.


Sintrom; a newer oral anticoagulant; preliminary report.


Fact and fad in the surgical treatment of periodontal disease.


Experience with paper electrophoresis of serum proteins.


Method of evaluating the clinical effect of warping a denture: report of a case.


Proximal gold foil restoration of posterior teeth.


Vibrator for the casting of amalgam dies in copper band impressions.


Denture reliners direct, hard, self-curing resin.


Pulp capping: a tooth saver.

Pulp capping: a tooth saver.


Dentistry's expanding horizons and increasing responsibilities.


Acrylic jacket crown with linguoincisal gold tip.


Endodontic treatment of deciduous teeth.


Dental study of a professional trumpet player.


Antarctic day of a naval dentist.

Antarctic day of a naval dentist.


A technic of dental health education for use at public health shows.


SURVEY of dentist opinion. II. Dental health education: dental fees.


SURVEY of the dental laboratory industry. III. Financial aspects of dental laboratories.


Some recent studies in the immunology of cancer. I. Detection of methyl-cholanthrene-like substance by the Schultz-Dale method in the sera of patients with tumors and in some apparently healthy persons.


Hosttumor antagonism. XIII. Sarcoma of the soft tissues treated by bacterial toxins: successful series.


Reduced sedative effect of a newly synthesized reserpine derivative (syrosingopine): clinical appraisal in primary hypertension.


Meprobamatebenactyzine (deprol) in the treatment of chronic brain syndrome, schizophrenia and senility.


Problems of medical management in homes for the aged.


Ocular surgery in the aged.

Ocular surgery in the aged.


Abdominal paracentesis as a diagnostic aid.


Electrocardiogram of patient in anaphylactic shock.


Simple bedside test of respiratory function.


Clinical evaluation of saline solution therapy in burn shock. II. Comparison of plasma therapy with saline solution therapy.


The mechanics of common football injuries.


Sociocultural stresses and the physician-patient relationship.


The psychotherapeutic approach to neurosis in the Pavlovian school.


Tissue necrosis and slough produced by metaraminol bitartrate.


Dihydrostreptomycin deafness.

Dihydrostreptomycin deafness.


Reserpine-induced gastrointestinal hemorrhage.


Cholestasis due to prochlorperazine.

Cholestasis due to prochlorperazine.


DANGER of suffocation from plastic bags.


NEW AND non-official drugs: cadmium sulfide.


Pulmonary granuloma due to brucellosis.

Pulmonary granuloma due to brucellosis.


NEW AND non-official drugs: triacetin.

NEW AND non-official drugs: triacetin.


NEW AND non-official drugs: cyclandelate.


Effect of alcohol on the liver.

Effect of alcohol on the liver.


The diabetic and his employment.

The diabetic and his employment.


Functions of a hospital in a major disaster.


Psychosomatic problems in a rapidly growing suburb.


Some psychosomatic aspects of asthma.

Some psychosomatic aspects of asthma.


Fatality after injection of sclerosing agent to precipitate fibro-osseous proliferation.


Cancerophobia and delusion.

Cancerophobia and delusion.


Response of trigeminal neuralgia to decompression of sensory root; discussion of cause of trigeminal neuralgia.


Fingertip hyperesthesia; solitary sign of new occupational dermatosis due to silica hair curlers.


Automatic detection and recording of cardiac arrhythmias.


Simplified technique for separation of cancer cells from blood.


Incidence of cholecystitis and other diseases among Pima Indians of Southern Arizona.


Electroshock therapy and tranquilizing drugs.


Chlorothiazide: a survey of its effects in hypertensive patients.


Coronary embolus.

Coronary embolus.


Coronary embolism with myocardial infarction; complication of verrucous endocarditis.


Thromboembolic disease in adolescence.

Thromboembolic disease in adolescence.


NEW AND non-official drugs: halothane.

NEW AND non-official drugs: halothane.


Steroid therapy and tuberculosis.

Steroid therapy and tuberculosis.


Accurate pregnancy testing in tranquilized patients.


Management of women with positive vaginal cytological findings.


Trophoblastic pulmonary thrombosis with cor pulmonale; report of a case due to malignant hydatiform mole of five years duration.


Hyperuricemia; relationship to hypercholesteremia and acute myocardial infarction.


Control of tetanus spasms by administration of meprobamate.


Hemoglobinuria after massive intraperitoneal hemorrhage.


Phentolamine hydrochloride in prevention of cutaneous necrosis due to levarterenol.


Carotid artery thrombosis in persons fifteen years of age or younger.


Huge osteoma of the eleventh left rib.

Huge osteoma of the eleventh left rib.


DEVELOPMENT and purpose of the registry on blood dyscrasias.


Exchange transfusion for aspirin poisoning.


Association of myxedema heart and arteriosclerotic heart disease.


NEW AND non-official drugs: benzonatate.


NEW AND non-official drugs; dicyclomine hydrochloride.


Intrafamilial and interfamilial spread of living vaccine strains of polioviruses.


Program of the Columbia University Institute of Nutrition Sciences.


Acute pancreatitis in patients receiving chlorothiazide.


Clinical therapeutic evaluation of hydrochlorothiazide (hydrodiuril).


Human pharmacology of thiazide derivatives.


Hemorrhage from multiple sites associated with chlorpromazine-induced jaundice.


Ototoxicity of kanamycin; report of three cases.


Consciousness and pain during apparent surgical anesthesia; report of a case.


Nausea and vomiting in the immediate postanesthetic period.


Agranulocytosis caused by phenothiazine derivatives.


Hypokalemic muscle paralysis associated with administration of chlorothiazide.


Sulfhemoglobinemia due to acetophenetidin.


Hepatic damage during chlorpropamide therapy.


Jaundice occurring during nicotinic acid therapy for hypercholesteremia.


NEW AND Nonofficial Drugs: erythromycin propionate.


NEW AND Nonofficial Drugs: relaxin.

NEW AND Nonofficial Drugs: relaxin.


NEW AND Nonofficial Drugs: syrosingopine.


Beta radiation sources, uses, and dangers in treatment of the eye.


Problem of antibiotics in foods.

Problem of antibiotics in foods.


Problems of impaired speech and language.


Some aspects of the pharmacology of ethyl-4-phenyl-1-[2-(phenylamino)ethyl]-piperidine-4-carboxylate (Win 13,797).


The evaluation of iodinated organic compounds as radiopaque media.


A new highly reactive aluminum hydroxide complex for gastric hyperacidity. I. In vitro rate of acid neutralization.


A new highly reactive aluminum hydroxide complex for gastric hyperacidity. II. In vitro buffering range and duration of action.


The preparation of some amides of bromal.


The kinetics of degradation of chlorobutanol.


Studies on local anesthetics. XVIII. Some new quaternary salts of basic carbamates.


Studies on local anesthetics. XIX. Substituted phenylcarbamates of piperidinopropanediol.


Studies on local anesthetics. XXI. Some derivatives of omega-diethylaminoacetanilide.


A comparison of the hypotensive effects of the monophosphoric acid ester of thiamine and thiamine hydrochloride.


Separation of decomposed products of phenobarbital sodium by paper chromatographic technique.


A new benzodixan derivative with adrenergic blocking activity; 2-(N,N-diallylcarbamylmethyl) aminomethyl-1,4-benzodioxan.


The preparation of oxidized derivatives of 1-ethylsulfonyl-4-ethylpiperazine.


Tritium-labeled meprobamate.

Tritium-labeled meprobamate.


A chromatographic examination of the alkaloidal fraction of Amanita pantherina.


Comparative activities and toxicities. III. D-Glucamine and glycine derivatives of nitro and halogenated benzenes.


A note on the preliminary phytochemical and biological study of Lomatium suksdorfii.


A note on the use of oxygen and carbon dioxide in perfusion fluids.


A note on the stability of vitamin B12 in the presence of thiochrome.


Studies on the adsorption of odorous materials. I. Surface potential changes of solid and liquid adsorbing surfaces.


Veratrum alkaloids. XXXII. The structures of germitetrine and some related hypotensive ester alkaloids.


A kinetic study of the hydrolysis of methyl DL-alpha-phenyl-2-piperidylacetate.


Intermediary metabolism of ergot. I. Amino acid metabolism.


Ion exchange separation method for microdetermination of tropane alkaloids in the presence of morphine.


Air-suspension technique of coating drug particles; a preliminary report.


An examination of the oil of the seeds of persimmon (Diospyros Virginiana L., fam. Ebenaceae.


Synthesis and antifungal studies on sorbic acid derivatives.


Binding of drugs by plastics. 1. Interaction of bacteriostatic agents with plastic syringes.


Studies on cell growth and cell division. I. A temperature-controlled system for inducing synchronous cell division.


Saponins and sapogenins. IV. Isolation of oleanolic acid from Sesbania aegyptica Pers.


Studies on cell growth and cell division. II. Selective activity of chloramphenicol and azaserine on cell growth and cell division.


Influence of glutathione on the inhibition of Escherichia coli by kanamycin.


Sulfaethylthiadiazole. V. Design and study of an oral sustained release dosage form.


Spectrophotofluorometry of reserpine, other Rauwolfia alkaloids, and related compounds.


A note on N-ethoxy-N-ethyl-m-toluamide insecticide.


Sensitivity to vaginal jellies: a note on the therapeutic index of spermicides.


A note on the crystallography of thenylpyramine hydrochloride.


An evaluation of some clinical data in the treatment of tinea pedis with copper sulphate iontophoresis and some fungicidal preparations.


Nail fungus; the problem and its management.


Post-operative pain control with dipyrone injectable.


Double ring hammer toe device.

Double ring hammer toe device.


Overtreatment dermatitis.

Overtreatment dermatitis.


Cervical spinal cord tumor: a case report.


Surgical removal of sebaceous cyst medial plantar margin of right heel.


Removal of head of middle phalanx.

Removal of head of middle phalanx.


Parenthood as a developmental phase; a contribution to the libido theory.


A procedure for evaluating the results of psychoanalysis; a preliminary report.


Psychoanalytic therapy in the light of follow-up.


Introspection, empathy, and psychoanalysis; an examination of the relationship between mode of observation and theory.


Certain technical problems in the transference relationship.


Transference derivatives of the family romance.


The vicissitudes of ego development in adolescence.


Problems of reanalysis.

Problems of reanalysis.


The silent patient.

The silent patient.


Some theoretical aspects of early psychic functioning.


A myxovirus (SF-4) associated with shipping fever of cattle.


Studies of shipping fever of cattle. I. Para-influenza 3 virus antibodies in feeder calves.


The evolution of laboratory animal medicine in the United States.


Skin grafting in the horse.

Skin grafting in the horse.


Treatment of canine nephritis.

Treatment of canine nephritis.


Some observations on the use of synthetic oxytocin in sows.


Ragweed allergy in the dog.

Ragweed allergy in the dog.


A parasitism in turkeys due to a Hemoproteus-like blood parasite.


Vertical integration in animal agriculture.


The genetic aspects of hip dysplasia in dogs.


Hereditary acetabular dysplasia in German shepherd dogs.


Epidemiological studies on equine encephalomyelitis in Maryland and Virginia.


Bilateral corneal dermoid in a calf; a case report.


Low fertility in turkeys associated with vibriosis.


Field trial involving parenteral use of benzathine penicillin V on Streptococcus agalactiae infections in two Holstein-Friesian dairy herds.


The intraperitoneal use of procaine hydrochloride with morphine-pentobarbital anesthesia.


Eperythrozoonosis in a herd of purebred Landrace pigs.


Congenital dysplasia of the hip in dogs.


DR. LESLIE M. HUTCHINGS; 1915-1959.

DR. LESLIE M. HUTCHINGS; 1915-1959.


Sodium pentachlorophenate as an ovicide for controlling ascariasis in swine.


Studies on metabolism of a chloramphenicol-producing Streptomyces with chlorine-36.


A product of Streptomyces exhibiting strong inhibition against Ehrlich carcinoma cells in vitro.


Studies on mikamycin. III. Characterization and hydrolysis.


Bacteriological studies on kanamycin. III. The cross resistance relation between kanamycin and dihydrostreptomycin in Mycobacterium 607.


Studies on the kanamycin-resistance of Mycobacterium tuberculosis. II. Kanamycin-sensitivity of various drug-resistant strains.


On the mode of action of kanamycin.

On the mode of action of kanamycin.


The effect of streptomycin in delaying the growth rate of streptomycin-resistant mutants of Mycobacterium tuberculosis.


Mouse leukemia C1498 and antitumor substances.


Variotin, a new antifungal antibiotic, produced by Paecilomyces varioti Bainier var. antibioticus.


Studies on phleomycin.

Studies on phleomycin.


Studies on mikamycin B.

Studies on mikamycin B.


Studies on toxin production of Clostridium botulinum type E. III. Characterization of toxin precursor.


Lower toxic derivatives of antibiotics. I. N-methanesulfonate derivatives of kanamycin and neomycin.


Kanamycin resistant staphylococcus mutant requiring heme for growth.


Stability of disseminated aerosols of Pasteurella tularensis subjected to simulated solar radiations at various humidities.


Serological types of Escherichia coli in association with infantile gastroenteritis.


Studies on the myxobacterium Chondrococcus columnaris. I. Serological typing.


Nucleic acid metabolism and ribonucleic acid heterogeneity in Escherichia coli.


Studies on the myxobacterium Chondrococcus columnaris. II. Bacteriocins.


Studies on the radiation inactivation of microorganisms. V. Deoxyribonucleic acid metabolism in ultraviolet-irradiated Haemophilus influenzae.


Mating reaction in Hansenula wingei; relation of cell surface properties to agglutination.


Observations on tissue cultures of mouse peritoneal exudates inoculated with Histoplasma capsulatum.


Studies of streptococcal cell walls. IV. The conversion of D-glucose to cell wall L-rhamnose.


Oral strains of Actinomyces.

Oral strains of Actinomyces.


Comparative pathogenicity of Candida albicans for mice and rabbits.


Electron microscopy of ultrathin sections of bacteria. III. Cell wall, cytoplasmic membrane, and nuclear material.


Microbiological determination of deoxyribonucleic acid; titrimetric estimation of thymidine.


Alterations in metal content of spores of Bacillus megaterium and the effect on some spore properties.


Microbiological determination of deoxyribonucleic acid; influence of deoxyribosides on the standard curves.


alpha-Amylase formation in growing and nongrowing cells of Pseudomonas saccharophila.


Comparative metabolism of species and types of organisms within the genus Brucella.


Selective antibacterial activity of aconitic acid.


Studies on immunity in anthrax. VII. Carbohydrate metabolism of Bacillus anthracis in relation to elaboration of protective antigen.


Ammonium salts as a sole source of nitrogen for the growth of Streptococcus bovis.


Cross resistance of Salmonella typhimurium to streptomycin and kanamycin.


Racemization of lysine by a pseudomonad.


Detection of diphosphopyridine nucleotidase-forming streptococci.


The hepatic glucose response to insulin in the un-anesthetized dog.


Effect of whole-body x-irradiation on glucose oxidation by rat small intestine mucosa in vitro.


The enzymatic sulfation of heparin.

The enzymatic sulfation of heparin.


The metabolism of acetol phosphate. II. 1,2-Propanediol-1-phosphate dehydrogenase.


A simple method for preparation of crystalline barium glucose 6-phosphate.


Labile fatty acids of rat diaphragm muscle and their possible role as the major endogenous substrate for maintenance of respiration.


Carbon dioxide activation in the pyruvate clastic system of Clostridium butyricum.


Reversal of pyruvate oxidation in Clostridium butyricum.


Formate metabolism by animal tissues. II. The mechanism of formate oxidation.


Enzymatic conversion of beta-hydroxypropionate to malonic semialdehyde.


Further observations on lipide stimulation of bacterial growth.


Studies on the estrogen-sensitive enzyme system from placenta.


Heterogeneity in the turnover rates of liver cholesterol esters.


Isolation and characterization of 3 beta-hydroxy-delta 5-steroids in adrenal carcinoma.


The separation and quantitative estimation of pregnane-3 alpha, 17 alpha, 20 alpha-triol, pregnane-3 alpha, 17 alpha, 20 alpha-triol-11-one, and other urinary acetaldehydogenic steroids.


Structure of the site phosphorylated in the phosphorylase b to a reaction.


Amperometric titration of disulfide and sulfhydryl in proteins in 8 M urea.


The relationship of disulfide bonds and activity in ribonuclease.


The effect of an altered secondary structure on ribonuclease activity.


The hydrolysis of carbobenzoxy-L-tyrosine p-nitrophenyl ester by various enzymes.


Azoproteins. I. Spectrophotometric studies of amino acid azo derivatives.


A new method for isolation of hydroxy-L-proline and L-proline from gelatin.


Studies on the reaction of sulfite with proteins.


Proline iminopeptidase.

Proline iminopeptidase.


Preparation and properties of guanidinated mercuripapain.


The nature of the amino acid residues involved in the inactivation of ribonuclease by iodoacetate.


The reaction of iodoacetate with methionine.


An alanine-dependent, ribonuclease-inhibited conversion of adenosine 5'-phosphate to adenosine triphosphate. II. Reconstruction of the system from purified components.


Comparative biochemistry of urea synthesis. I. Methods for the quantitative assay of urea cycle enzymes in liver.


Comparative biochemistry of urea synthesis. II. Levels of urea cycle enzymes in metamorphosing Rana catesbeiana tadpoles.


The oxidation of glycine and formate to CO2 by rat liver homogenates.


The mechanism of the enzymatic cleavage of S-adenosylmethionine to alpha-amino-gamma-butyrolactone.


Biosynthesis of the purines. XXIII. The enzymatic synthesis of N-(5-amino-1-ribosyl-4-imidazolylcarbonyl)-L-aspartic acid 5'-phosphate.


The independence of hydrocortisone and tryptophan inductions of tryptophan pyrrolase.


Biosynthesis of the purines. XXIV. The enzymatic synthesis of 5-amino-1-ribosyl-4-imidazolecarboxylic acid 5'-phosphate from 5-amino-1-ribosylimidazole 5'-phosphate and carbon dioxide.


Biosynthesis of the purines. XXV. The enzymatic cleavage of N-(5-amino-1-ribosyl-4-imidazolylcarbonyl)-L-aspartic acid 5'-phosphate.


Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reactions.


Uridine diphosphoacetylglucosamine pyrophosphorylase.


N-Methyl-4-pyridone-5-carboxamide, a new major normal metabolite of nicotinic acid in rat urine.


The preparation of uridine diphosphoacetyl-galactosamine.


The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid.


Goitrin from fresh cabbage.

Goitrin from fresh cabbage.


A comparison of some biochemical properties of the beef liver and beef kidney rhodaneses.


The distribution of sulfur-containing compounds in penicillin fermentations.


The biosynthesis of patulin. III. Evidence for a molecular rearrangement of the aromatic ring.


A triphosphopyridine nucleotide-cytochrome c reductase from heart muscle.


Studies of electron transport enzymes. III. Cytochrome b5 of pig liver mitochondria.


The photo-reduction of pyridine nucleotides by illuminated chromatophores of Rhodospirillum rubrum in the presence of succinate.


Photo-oxidations catalyzed by chromatophores of Rhodospirillum rubrum under anaerobic conditions.


The inhibition of xanthine and succinic oxidases by carbonyl reagents.


Further studies with xanthine oxidase inhibitors.


Phosphate inhibition of citrate oxidation in kidney tissue.


Studies on phenol-activated oxidation of reduced nucleotides by rat uterus.


Further observations on the effect of isooctane on respiratory enzymes.


Studies on the electron transfer system. XXV. The isolation and properties of a lipoflavoprotein with diaphorase activity from beef heart mitochondria.


Condensing enzyme in garcinia leaves (Xanthochymus guttiferae).


Effects of growth hormone in vitro on the metabolism of glucose in rat adipose tissue.


The enzymatic formation of D-arabinose 5-phosphate from L-arabinose and adenosine triphosphate by Propionibacterium pentosaceum.


Studies of liver glucose 6-phosphatase. III. Solubilization and properties of the enzyme from normal and diabetic rats.


A sensitive colorimetric method for the estimation of 2-deoxy sugars with the use of the malonaldehyde-thiobarbituric acid reaction.


The endogenous glycogen of rat diaphragm and its theoretical capacity to support respiration.


Metabolic activity in calcified tissues: aconitase and isocitric dehydrogenase activities in rabbit and dog femurs.


The natural occurrence of sedoheptulose monophosphate in liver.


The distribution and utilization of glucose in isolated lymph node cells.


The action of an amyloglucosidase of Aspergillus niger on starch and malto-oligosaccharides.


The thiobarbituric acid assay of sialic acids.


Biochemistry of long chain fatty acids. I. General observations.


Biochemistry of long chain fatty acids. II. Metabolic studies.


Studies on the biosynthesis of glycolipides and other lipides of the brain.


Possible metabolic functions of deoxycytidine diphosphate choline and deoxycytidine diphosphate ethanolamine.


The mechanism of formation of succinate and propionate by Ascaris lumbricoides muscle.


Metabolism of C-16-oxygenated steroids by human placenta: the formation of estriol.


Bacterial oxidation of steroids. I. Ring A dehydrogenations by intact cells.


Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation.


Bile acids and steroids. LXXXII. On the mechanism of deoxycholic acid formation in the rabbit.


Separation of human placental estrogen-sensitive transhydrogenase from estradiol-17 beta dehydrogenase.


Bile acids and steroids. LXXXIII. On the inter-conversion of cholic and deoxycholic acid in the rat.


Preputial gland tumor sterols. I. The occurrence of 24,25-dihydrolanosterol and a comparison with liver and the normal gland.


Studies on the antigenic structure of ribonuclease. I. General role of hydrogen and disulfide bonds.


Preparation and characterization of a fully iodinated insulin derivative.


The flavoprotein-apoprotein system of egg white.


The metabolism of carbon-labeled urea in the germ free rat.


Biosynthesis of methionine in liver.

Biosynthesis of methionine in liver.


Hydroxyproline metabolism. I. Conversion to alpha-ketoglutarate by extracts of Pseudomonas.


Protein synthesis by rabbit reticulocytes. I. Kinetics of amino acid incorporation in vitro into protein fractions of intact cells.


Protein synthesis by rabbit reticulocytes. II. Interruption of the pathway of hemoglobin synthesis by a valine analogue.


Pyrimidine metabolism. IV. A comparison of normal and regenerating rat liver.


6-Chloropurine and 6-chlorouric acid as substrates and inhibitors of purine-oxidizing enzymes.


Studies on polynucleotides. III. Enzymic degradation; substrate specificity and properties of snake venom phosphodiesterase.


Studies on polynucleotides. IV. Enzymic degradation; the stepwise action of venom phosphodiesterase on deoxyribo-oligonucleotides.


The utilization of acetate-C14 by Escherichia coli grown on acetate as the sole carbon source.


DDT dehydrochlorinase. II. Substrate and cofactor specificity.


DDT dehydrochlorinase. I. Isolation, chemical properties, and spectrophotometric assay.


N-(6-Hydroxy-2-fluorenyl) acetamide, a urinary metabolite after intraperitoneal injection of N-2-fluorenylacetamide into rats.


The metabolism of aromatic compounds in higher plants. I. Coumarin and o-coumaric acid.


Enzymatic formation of polysulfides from mercaptopyruvate.


Equilibrium and kinetic studies of the pyruvic kinase reaction.


Pyrrolidine and putrescine metabolism: gamma-aminobutyraldehyde dehydrogenase.


The intracellular occurrence of reduced diphosphopyridine nucleotide-coupled reactions in liver and kidney.


The natural occurrence of coenzyme Q and related compounds.


Formation of the nicotinic acid analogue of diphosphopyridine nucleotide after nicotinamide administration.


Studies on the mechanism by which anaerobiosis prevents swelling of mitochondria in vitro: effect of electron transport chain inhibitors.


Reversal of thyroxine-induced swelling of rat liver mitochondria by adenosine triphosphate.


Photophosphorylation by digitonin-fragmented spinach chloroplasts.


A note on the distribution of phosphorus in photophosphorylating spinach chloroplast preparations.


Oxidative photosynthetic phosphorylation by spinach chloroplasts.


Studies on the mitochondrial alpha-glycerophosphate dehydrogenase. I. Reaction of the dehydrogenase with electron acceptors and the respiratory chain.


Electron microscope study of the human neuromuscular junction. A preliminary electron microscope study of human neuromuscular junction is presented. The biopsy material was taken from the palmarus longus, and fixed routinely in osmium tetroxide and embedded in methacrylate. The structure of the motor endings and the relationship of the synaptic vesicles to the axolemmal membrane are described. The synaptic clefts are filled with an homogeneous material in continuity with the basement membrane covering the muscle fiber. The subneural apparatus is described, and special attention is paid to a vesicular component present in the sarcoplasm of the junctional area, which differs from synaptic vesicles and is presumed to be a derivate of the sarcoplasmic reticulum.


Nuclear-cytoplasmic relationships in human cells in tissue culture. III. Auto-radiographic study of interrelation of nuclear and cytoplasmic ribonucleic acid. The movement of ribonucleic acid (RNA) from nucleus to cytoplasm has been studied, by autoradiographic techniques, in cells of the human amnion grown in tissue culture. Cells were exposed to cytidine-H(3) for 1 hour after which time only the RNA of the nuclei was labelled. After this 1 hour exposure the cells were placed in a medium containing an excess amount of unlabelled cytidine. Periodically, cells from this medium were fixed. Autoradiographs showed that there was a progressive movement of the label from nucleus to cytoplasm, such that after 24 hours essentially all the label was in the RNA of the cytoplasm. A study of the incorporation of the cytidine-H(3) in deoxyribonucleic acid (DNA), in the same population of cells at the same times, indicated that the presence of excess amounts of unlabelled cytidine almost instantaneously inhibited further utilization of cytidine-H(3). It is concluded that RNA moves from nucleus to cytoplasm as a complex polynucleotide structure.


The fine structure of the adepidermal reticulum in the basal membrane of the skin of the newt, Triturus. The unique reticulum in the basal membrane of the adult newt's skin consists of a series of nodular swellings from which there radiate fibers. Electron micrographic studies showed that the nodules consist of layers of fibrillae arranged approximately and irregularly at right angles to one another. Some are packed to form a capsule; still others extend into the internodular zone to form the radiating fibers. The fibrils are banded and are revealed best after fixation with potassium permanganate. The reticulum is compared with that of the larval newt and the frog tadpole. The epidermal side of the reticulum is bounded by a membrane separated from the plasma wall of the epidermal cell by a clear space. These we have termed adepidermal membrane and space, and have compared them with similar structures in larvae.


Nucleoprotein changes in plant tumor growth. Tumor cell transformation and growth were studied in a plant neoplasm, crown gall of bean, induced by Agrobacterium rubi. Ribose nucleic acid (RNA), deoxyribose nucleic acid (DNA), histone, and total protein were estimated by microphotometry of nuclei, nucleoli, and cytoplasm in stained tissue sections. Transformation of normal cells to tumor cells was accompanied by marked increases in ribonucleoprotein content of affected tissues, reaching a maximum 2 to 3 days after inoculation with virulent bacteria. Increased DNA levels were in part associated with increased mitotic frequency, but also with progressive accumulation of nuclei in the higher DNA classes, formed by repeated DNA doubling without intervening reduction by mitosis. Some normal nuclei of the higher DNA classes (with 2, 4, or 8 times the DNA content of diploid nuclei) were reduced to diploid levels by successive cell divisions without intervening DNA synthesis. The normal relation between DNA synthesis and mitosis was thus disrupted in tumor tissue. Nevertheless, clearly defined DNA classes, as found in homologous normal tissues, were maintained in the tumor at all times.


Electron microscope observations of the melanocyte of the human epidermis. Using standard osmium fixation and methacrylate embedding techniques, a study has been made of the melanocyte of human biopsy skin removed under general and local anaesthesia. Melanogenesis was easily observable in the melanocytes, but immature pigment granules were rarely seen in the Malpighian cells. The passage of melanin from melanocyte to Malpighian cell-cytocrine secretion-is thought to have been observed. Phagocytes near the dermal-epidermal junction seem to have their pigment granules in vacuoles, rather than surrounded directly by the cytoplasmic matrix as in the melanocytes. This, together with the failure to observe "effete" melanocytes, prompts the suggestion that the phagocytes are melanocytes which have migrated from the epidermis into the dermis. A melanin granule is shown with alternating dark and lighter transverse striations, concerning which structure little can at present be said.


The isolation of nucleoli from ungerminated pea embryos. A method is described for the isolation of nuclei and nucleoli from ungerminated pea embryos. Electron micrographs of the nucleolar preparation indicate a high degree of purity but only a partial preservation of composition, because of a loss of material from the nucleoli which occurs during the isolation procedure.


Spermiogenesis in Lumbricus herculeus; an electron microscope study. Small pieces of the sperm sacs of Lumbricus herculeus were fixed for 4 hours in chrome-osmium, embedded in methacrylate, sectioned with a Porter-Blum microtome, and studied with a R.C.A. EMU-2C electron microscope. Each spermatid of a group developing synchronously is attached by a cytoplasmic strand to a common nutrient protoplasmic mass. This mass contains mitochondria and yolk bodies but is anucleate. The proximal centriole, that is, the centriole nearer the nucleus, is at first associated with a small peg which becomes firmly attached to the nuclear membrane. Later these two bodies become separated during the development of the middle-piece which is differentiated in the usual manner from a nebenkern formed by the fusion of 6 or 7 mitochondria. The acrosome develops in relation to the dictyosome (Golgi body), itself composed of 8 or more individual flattened sacs and situated in the cytoplasm opposite the point of attachment of the spermatid to the nutrient mass. Soon after its formation, the acrosome becomes incorporated into a cytoplasmic appendage or acrosome carrier. The carrier moves from its original position, along the lateral border of the elongating nucleus, to the distal margin of the nucleus where the acrosome is deposited. No evidence was found of a centriole located at the point of junction between nucleus and acrosome as suggested by earlier workers.


Some chemical properties of isolated pea nucleoli. Isolated nuclei and nucleoli of ungerminated pea embryos have been analyzed chemically for their content of DNA, RNA, zinc, iron, phosphorus, and protein sulfhydryl groups. The values obtained cannot be considered to represent the whole of the living nucleolar body as an undetermined amount of material is extracted from nucleoli in the course of their isolation. Only negligible amounts of DNA have been found in the isolated nucleoli; most of the DNA released on disruption of nuclei appears in a fraction showing very few structures under the light microscope. RNA is more concentrated in the nucleolus than in the nucleus or cytoplasm, but since nucleolar protein is 6 per cent of nuclear and less than 1 per cent of cytoplasmic protein, the total amount of nucleolar RNA is comparatively small. None of the other components listed occurs in high concentration in either nucleus or nucleolus.


Intercellular bridges as protoplasmic anastomoses between smooth muscle cells. In electron microscopic studies, protoplasmic anastomoses were found to occur between smooth muscle cells in the gastrointestinal tracts of rats. The protoplasmic connections are apparently cylindrical in form and contain cytoplasm having a density similar to that of the cellular regions connected. The membranes enclosing the cytoplasmic connections are continuous with the membranes of the connected cells. These connecting structures have been called intercellular bridges, which is adequately descriptive if emphasis is placed on the interpretation that they represent protoplasmic anastomoses. To emphasize this, the term may be modified; i.e., anastomotic intercellular bridges. In some cellular connections, transverse diffuse lines are seen. These may be interpreted as either disintegrating or reforming plasma membranes which is consistent with the concept that protoplasmic continuity is transitory. Since the animals were dissected under hypothermia, reduction of muscular activity by the chilling may have helped to preserve the structure of existing anastomotic intercellular bridges. The intercellular protoplasmic anastomoses may play a role in the conduction of action potentials from one smooth muscle cell to another.


Some observations on the fine structure of the giant nerve fibers of the earthworm, Eisenia foetida. Sectioned dorsal giant fibers of the earthworm Eisenia foetida have been studied with the electron microscope. The giant axon is surrounded by a Schwannian sheath in which the lamellae are arranged spirally. They can be traced from the outer surface of the Schwann cell to the axon-Schwann membranes. Irregularities in the spiral arrangement are frequently observed. Desmosome-like attachment areas occur on the giant fiber nerve sheath. These structures appear to be arranged bilaterally in columns which are oriented slightly obliquely to the long axis of the giant fiber and aligned linearly from the axon to the periphery of the sheath. At these sites they bind together apposing portions of Schwann cell membrane comprising the sheath. Longitudinal or oblique sections of the nerve sheath attachment areas are reminiscent of the Schmidt-Lantermann clefts of vertebrate peripheral nerve. Septa of the giant fibers have been examined. They are symmetrical or non-polarized and consist of the two plasma membranes of adjacent nerve units. Characteristic vesicular and tubular structures are associated with both cytoplasmic surfaces of these septa.


Electron microscope studies of the human epidermis; the cell boundaries and topography of the stratum malpighii. The thin skin of the left upper quadrant of the human abdomen has been studied by electron microscopy. Tissue removed with a high speed rotary punch was fixed in osmium tetroxide or potassium permanganate. The latter fixative in our preparations is superior to osmium for the demonstration of epidermal cell membranes and certain other membranous structures of the epidermis. The cytoplasmic membranes of basal cells and cells of the stratum granulosum have been found to be relatively straight, while those of most spinous cells are sharply scalloped. The deep cells of the stratum spinosum in the rete ridge area show cell membranes and cytoplasmic structure intermediate between true basal cells and most cells of the stratum spinosum. The extracellular material of the desmosome has been found to consist of alternate dark and light laminae similar to those described by Odland (13) and Horstmann and Knoop (7).


Reticular and areticular Nissl bodies in sympathetic neurons of a lizard. Sympathetic ganglia of the horned lizard, Phrynosoma cornutum, were fixed in OsO(4) and imbedded in methacrylate. Thin sections were cut for electron microscopy. Some adjacent thick sections were cut for light microscopy and were stained in acidified, dilute thionine both before and after digestion by RNase. In the light microscope two types of Nissl bodies are found, both removable by RNase: (1) a deep, diffuse, indistinctly bounded, metachromatic variety, and (2) a superficial, dense, sharply delimited, orthochromatic sort. Electron microscopically, the former ("reticular" Nissl bodies) corresponds to the granulated endoplasmic reticular structure of Nissl material previously described by others, whereas the latter ("areticular" Nissl bodies) comprises compact masses of particles of varying internal density and devoid of elements of endoplasmic reticulum. The constituent particles of the areticular Nissl material are 4 to 8 x the diameter of single ribonucleoprotein granules of the reticular Nissl substance and seem, near zones of junction with the reticular type, to arise by clustering of such granules with subsequent partial dispersion of the substance of the granules into an added, less dense material. It is suggested that the observed orthochromasia of the areticular Nissl substance is due to accumulation of a large amount of protein bound to RNA and, further, that these Nissl bodies may represent storage depots of RNA and protein.


Mitochondria. I. Fine structure of the complex patterns in the mitochondria of Pelomyxa carolinensis Wilson (Chaos chaos L.). Some of the mitochondria in the free-living giant ameba Pelomyxa carolinensis (Chaos chaos) exhibit unusual and strikingly complex morphological patterns. A study of serial sections of these mitochondria reveals that the patterns are formed by the organization and packing of minute villi (cristae mitochondriales). The form of the individual villus is a regular soft zigzag (or wave) with a bulbous enlargement at each point of inflection ("elbow") on the wave. The pattern of the mitochondria may become increasingly complex as a result of branching and fusing of the wavy villi. Densely packed fibrillar material is sometimes present in the stroma of the mitochondria.


Mitochondria. II. The nuclear-mitochondrial relationship in Pelomyxa carolinensis Wilson (Chaos chaos L.). This study has demonstrated that in the ameba, Pelomyxa carolinensis Wilson (Chaos chaos L.) the limiting membranes of mitochondria and postdivision nuclei are often continuous. The morphological relationship may be functional in that it permits an exchange of material resulting directly or indirectly in an increased enzyme content of the mitochondria. It is suggested that through a series of progressive foldings of its envelope, the nucleus may be a site of formation of mitochondria.


Electron microscope study of lens fibers. Comparative electron microscope investigations on sections of the lens cortex of the normal, mature rat, rabbit, monkey, and the normal calf reveal similar patterns of intracellular organization. The superficial lens fiber contains a nucleus, mitochondria, endoplasmic reticulum, dense granules, Golgi complex, and a quantity of small structures of low opacity which appear as filamentous and spherical configurations. Variations in number, distribution, and spatial arrangement of cytoplasmic elements in lens fibers are described. These changes in the pattern of cytoplasmic organization are concomitant with development of fibers and their displacement towards the center of the lens. Structural details of the various zones of the lens epithelium and the lens fibers are compared.


zeta-Collidine as a basis for buffering fixatives.


An improved grid-holder for the Siemens electron microscope.


The nuclear envelope after KMnO4 fixation.


Phagotrophy and two new structures in the malaria parasite Plasmodium berghei. Blood collected from rats infected with Plasmodium berghei was centrifuged and the pellet was fixed for 1 hour in 1 per cent buffered OsO(4) with 4.9 per cent sucrose. The material was embedded in n-butyl methacrylate and the resulting blocks sectioned for electron microscopy. The parasites were found to contain, in almost all sections, oval bodies of the same density and structure as the host cytoplasm. Continuity between these bodies and the host cytoplasm was found in a number of electron micrographs, showing that the bodies are formed by invagination of the double plasma membrane of the parasite. In this way the host cell is incorporated by phagotrophy into food vacuoles within the parasite. Hematin, the residue of hemoglobin digestion, was never observed inside the food vacuole but in small vesicles lying around it and sometimes connected with it. The vesicles are pinched off from the food vacuole proper and are the site of hemoglobin digestion. The active double limiting membrane is responsible not only for the formation of food vacuoles but also for the presence of two new structures. One is composed of two to six concentric double wavy membranes originating from the plasma membrane. Since no typical mitochondria were found in P. berghei, it is assumed that the concentric structure performs mitochondrial functions. The other structure appears as a sausage-shaped vacuole surrounded by two membranes of the same thickness, density, and spacing as the limiting membrane of the body. The cytoplasm of the parasite is rich in vesicles of endoplasmic reticulum and Palade's small particles. Its nucleus is of low density and encased in a double membrane. The host cells (reticulocytes) have mitochondria with numerous cristae mitochondriales. In many infected and intact reticulocytes ferritin was found in vacuoles, mitochondria, canaliculi, or scattered in the cytoplasm.


The histochemical demonstration of secretory capillaries in the pancreas with the aid of substrate specific phosphatases.


Electron microscopy of neuroglial fibrils of the cerebral cortex.


The preparation of carbon films for electron microscopy.


Electron microscope and x-ray diffraction studies of a saturated synthetic phospholipide.


The fine structure of an elementary contractile system.


Electron microscopy of two subcellular fractions isolated from cerebral cortex homogenate.